Bradykinin is involved in hyperalgesia induced by Bothrops jararaca venom.
Bradykinin is involved in hyperalgesia (pain hypersensitivity) induced by Bothrops jararaca venom-intraplantar injection of B. jararaca venom (5microg/paw) in rats caused hyperalgesia, which peaked 1h after venom injection. This phenomenon was not modified by promethazine (H(1) receptor antagonist), methysergide (5-HT receptor antagonist), guanethidine (sympathetic function inhibitor), anti-TNF-alpha or anti-interleukin-1 antibodies or by the chelating agent CaNa(2)EDTA. Venom-induced hyperalgesia was blocked by the bradykinin B(2) receptor antagonist HOE 140. On the other hand, des-Arg(9), [Leu(8)]-bradykinin, a bradykinin B(1) receptor antagonist, did not modify the hyperalgesic response. These results suggest that bradykinin, acting on B(2) receptor, is a mediator of hyperalgesia induced by B. jararaca venom.
Chacur
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Laboratório de Fisiopatologia, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, Brazil.
Picolo
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Teixeira
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CF
Cury
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Y
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D017837:Bothrops / Q000502:physiology*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*; D065168:Bradykinin Receptor Antagonists; D003435:Crotalid Venoms / Q000633:toxicity*; D004359:Drug Therapy, Combination; D006930:Hyperalgesia / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000319:Adrenergic beta-Antagonists; D065168:Bradykinin Receptor Antagonists; D003435:Crotalid Venoms; C065679:icatibant; D001920:Bradykinin