Renin-producing serous cystoadenocarcinoma of the ovary: a case report.
BACKGROUND
Only a few renin-producing ovarian tumors have been reported, and most such ovarian tumors have been sex cord/stromal tumors. Renin-producing ovarian epithelial tumors are quite rare.


METHODS
A 46-year-old woman presented with hypertension and hypokalemia. Examinations of the patient revealed elevated plasma renin activity, hyperaldosteronism and a pelvic mass. Subsequently, a right ovarian tumor mass was resected. Microscopic observation of the tumor revealed a well-differentiated serous cystadenocarcinoma. Immediately after surgery, blood pressure, serum potassium, plasma renin activity and plasma aldosterone levels returned to normal ranges. RT-PCR analysis and immunohistochemical staining of this tumor indicated that it was producing renin.


CONCLUSIONS
This is the first report of a renin-producing ovarian serous cystadenocarcinoma.
Iwamoto
H
H
Department of Obstetrics and Gynecology, Yamanashi Medical University, Japan.
Hirata
S
S
Honda
T
T
Fukasawa
H
H
Kimura
N
N
Hoshi
K
K
D000450:Aldosterone / Q000097:blood; D018284:Cystadenocarcinoma, Serous / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications; D006973:Hypertension / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012083:Renin / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000450:Aldosterone; D012083:Renin