Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease.
In the present study, we tried to clarify the potentially protective role of Bcl-x(L), an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (PD). Using in situ hybridization on human postmortem mesencephalon sections, we show that in PD patients Bcl-x(L) mRNA expression per dopaminergic neuron was almost double that of controls. We also show that, ultrastructurally, this effect may be mediated by a redistribution of Bcl-x(L) from the cytosol to the outer mitochondrial membrane.
Hartmann
Andreas
A
INSERM U 289, Hôpital de la Salpêtrière, 75013 Paris, France.
Mouatt-Prigent
Annick
A
Vila
Miquel
M
Abbas
Nacer
N
Perier
Céline
C
Faucheux
Baptiste A
BA
Vyas
Sheela
S
Hirsch
Etienne C
EC
D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000502:physiology*; D004295:Dihydroxyphenylalanine / Q000502:physiology; D006801:Humans; D008543:Melanins / Q000378:metabolism; D008636:Mesencephalon / Q000378:metabolism / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D009928:Organ Specificity; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000378:metabolism / Q000648:ultrastructure; D012333:RNA, Messenger / Q000096:biosynthesis; D051020:bcl-X Protein
C494811:BCL2L1 protein, human; D008543:Melanins; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051020:bcl-X Protein; C014121:neuromelanin; D004295:Dihydroxyphenylalanine