title: Convenient preparation of tert-butyl beta-(protected amino)esters.
abstract: Refluxing an aldehyde 1 with benzotriazole and benzylcarbamate in the presence of a catalytic amount of p-TsOH gave the corresponding benzyloxycarbonylamino-1-(1-benzotriazolyl)alkane 2 in good yields. Compounds 2 treated with substituted tert-butyl acetates 3 using LDA as a base afford smoothly and under mild conditions the N-2-protected 3-aminoalkanoic esters 4.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Kostyantyn
authors.initials: K
authors.lastname: Kirichenko
authors.forename: Ahamad M
authors.initials: AM
authors.lastname: Elsayed
authors.forename: Yu
authors.initials: Y
authors.lastname: Ji
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Fang
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Steel