title: Synthesis of a novel, recyclable, solid-phase acylating reagent.
abstract: In this paper, we describe the synthesis of N-(6-cyano-1,3-dimethyl-2,4-dioxo-5-substituted-1,3-dihydropyridino[2,3-d] pyrimidin-7-yl)imides 1. We will show the synthesis of 1 using both conventional heating and microwave techniques. In addition, the imide was attached to polystyrene and this immobilized imide was equally as effective at acylating various primary and secondary amines as its solution-phase counterpart.
authors.affiliation: Department of Chemistry ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, USA. rnicewonger@arqule.com
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nicewonger
authors.forename: Lori
authors.initials: L
authors.lastname: Ditto
authors.forename: Doug
authors.initials: D
authors.lastname: Kerr
authors.forename: Laszlo
authors.initials: L
authors.lastname: Varady
mesh_terms: D019840:2-Propanol / Q000737:chemistry; D000215:Acylation; D000588:Amines / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D007094:Imides / Q000138:chemical synthesis*; D008872:Microwaves; D011137:Polystyrenes / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry
chemical_list: D000588:Amines; D001565:Benzoates; D007094:Imides; D011137:Polystyrenes; D011725:Pyridines; D019840:2-Propanol; C023666:pyridine; C013409:benzoyl chloride