Neonatal lupus erythematosus.
Neonatal lupus erythematosus is associated with cutaneous lesions, CHB, hepatic disease, and thrombocytopenia. IgG antibodies to Ro and/or La cross the placenta and participate in the development of the clinical manifestations. Mothers of babies with NLE are likely to develop collagen vascular diseases with time. Infants with NLE are at risk to develop other autoimmune diseases during childhood or adolescence.
Burch
Joanna M
JM
University of Colorado Health Sciences Center, Denver, CO, USA.
Lee
Lela A
LA
Weston
William L
WL
D000974:Antibodies, Antinuclear; D001327:Autoimmune Diseases; D006327:Heart Block / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital* / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies