Cytotoxic sphingosine 4-sulfates from the sponge Spirastrella abata.
Two new sphingosine 4-sulfates (1 and 2) have been isolated from the sponge Spirastrella abata as cytotoxic constituents. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their stereochemistry was established by chemical conversion. The compounds exhibited significant cytotoxicity against a small panel of five human tumor cell lines.
Alam
Naseer
N
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Wang
Weihong
W
Hong
Jongki
J
Lee
Chong-Ok
CO
Im
Kwang Sik
KS
Jung
Jee H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms; D015394:Molecular Structure; D009423:Nervous System Neoplasms; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D011161:Porifera / Q000737:chemistry*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D013431:Sulfates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D013431:Sulfates; D013110:Sphingosine