The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population.
OBJECTIVE
A single nucleotide polymorphism (SNP) T1128C, which causes an amino acid change from leucine(7) to proline(7) in the signal peptide of neuropeptide Y (NPY), has been found to be associated with multiple clinical parameters or disease. However, this SNP was not identified in the Japanese population. We asked if this is also true in the Korean population.


METHODS
Genotyping was conducted by pyrosequencing, a newly developed real-time high-throughput SNP scoring technique.


RESULTS
All 242 Korean subjects showed T1128/T1128 genotype.


CONCLUSIONS
The T1128C SNP does not appear to exist in this Korean population.
Ding
B
B
Center for Genomics and Bioinformatics, Karolinska Institute, S-171 77, Stockholm, S-17186, Sweden.
Bertilsson
L
L
Wahlestedt
C
C
D000328:Adult; D001483:Base Sequence; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007723:Korea; D007930:Leucine / Q000235:genetics; D009478:Neuropeptide Y / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011392:Proline / Q000235:genetics; D021382:Protein Sorting Signals / Q000235:genetics
D009478:Neuropeptide Y; D021382:Protein Sorting Signals; D011392:Proline; D007930:Leucine