T(15;17) in acute promyelocytic leukemia is not associated with submicroscopic deletions on der(17).
We report a fluorescent in situ hybridization (FISH) study on 34 patients with acute promyelocytic leukemia. The study was designed to detect microdeletions in the derivative chromosome 17 which is the result of a reciprocal translocation t(15;17). No deletion was found.
Specchia
Giorgina
G
Albano
Francesco
F
Storlazzi
Clelia T
CT
Anelli
Luisa
L
Zagaria
Antonella
A
Liso
Vincenzo
V
Rocchi
Mariano
M
D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D014178:Translocation, Genetic