title: Large-scale outbreak of infection with Mycobacterium chelonae subsp. abscessus after penicillin injection.
abstract: An outbreak of infection with Mycobacterium chelonae subsp. abscessus after the injection of penicillin in 86 patients attending a factory hospital is reported. The bacterium was isolated both from lids and from the soil where the drug was stored. Molecular analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell proteins and plasmids revealed a pattern identical to that of the strains isolated from the wounds. The source of the infections was soil contamination of the vial lids and was caused by improper use and sterilization of penicillin vials.
authors.affiliation: Department of Microbiology, Chongqing University of Medical Science, Chongqing, People's Republic of China 400016. dryangfm365@sina.com
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhibang
authors.forename: Zhang
authors.initials: Z
authors.lastname: BiXia
authors.forename: Lu
authors.initials: L
authors.lastname: Qishan
authors.forename: Chen
authors.initials: C
authors.lastname: Lihao
authors.forename: Liu
authors.initials: L
authors.lastname: Xiangquan
authors.forename: Li
authors.initials: L
authors.lastname: Huaping
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D004340:Drug Contamination; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease / Q000453:epidemiology*; D007223:Infant; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D016926:Mycobacterium chelonae / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects; D010957:Plasmids / Q000235:genetics / Q000302:isolation & purification; D012988:Soil Microbiology; D013242:Sterilization
chemical_list: D001426:Bacterial Proteins; D010400:Penicillin G