title: Pathogenesis of streptococcal and staphylococcal endocarditis.
abstract: Although streptococcal and S. aureus IE share the same primary site of infection, their pathogenesis and clinical evolution present several major differences. Streptococci adhere to cardiac valves with pre-existing endothelial lesions. In contrast, S. aureus can colonize either damaged endothelium or invade physically intact endothelial cells. These interactions are mediated by multiple surface adhesins, some of which have been only partially characterized. Streptococci produce surface glucans (gtf and ftf), ECM adhesins (e.g., fibronectin-binding proteins, FimA), and platelet aggregating factors (phase I and phase II antigens, pblA, pblB, and pblT), all of which have been.
authors.affiliation: Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, BH19 Rue du Bugnon, 1011 Lausanne, Switzerland. pmoreill@chuv.hospvd.ch
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreillon
authors.forename: Yok A
authors.initials: YA
authors.lastname: Que
authors.forename: Arnold S
authors.initials: AS
authors.lastname: Bayer
mesh_terms: D018829:Adhesins, Bacterial / Q000145:classification / Q000378:metabolism; D000954:Antigens, Surface / Q000009:adverse effects / Q000378:metabolism; D001426:Bacterial Proteins / Q000145:classification / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D004697:Endocarditis, Bacterial / Q000382:microbiology* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000382:microbiology; D006351:Heart Valves / Q000254:growth & development / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000473:pathology; D013210:Staphylococcus / Q000472:pathogenicity; D013290:Streptococcal Infections / Q000382:microbiology* / Q000473:pathology; D013291:Streptococcus / Q000472:pathogenicity; D013925:Thromboplastin / Q000378:metabolism
chemical_list: D018829:Adhesins, Bacterial; D000954:Antigens, Surface; D001426:Bacterial Proteins; C048165:adhesin, Staphylococcus aureus; D013925:Thromboplastin