title: Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins.
abstract: This review describes the ionic mechanisms involved in the nodal swelling of frog myelinated axons caused by specific marine neurotoxins (ciguatoxins, brevetoxins, Conus consors toxin and equinatoxin-II), analysed using confocal laser scanning microscopy. We have focussed on toxins that either target neuronal voltage-dependent Na+ channels, or that form cation-selective pores and indirectly affect the functioning of the Na(+)-Ca(++)exchanger.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire et Moléculaire, UPR 9040, Institut Fédératif de Neurobiologie Alfred Fessard, CNRS, bat. 32-33, 91198 Gif sur Yvette Cedex, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Benoit
authors.forename: Cesar
authors.initials: C
authors.lastname: Mattei
authors.forename: Gilles
authors.initials: G
authors.lastname: Ouanounou
authors.forename: Frederic A
authors.initials: FA
authors.lastname: Meunier
authors.forename: Dusan
authors.initials: D
authors.lastname: Suput
authors.forename: Frederic
authors.initials: F
authors.lastname: Le Gall
authors.forename: Michel
authors.initials: M
authors.lastname: Marquais
authors.forename: Marie Y
authors.initials: MY
authors.lastname: Dechraoui
authors.forename: Jordi
authors.initials: J
authors.lastname: Molgo
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D002412:Cations; D002922:Ciguatoxins / Q000494:pharmacology*; D003064:Cnidarian Venoms / Q000494:pharmacology*; D006801:Humans; D007477:Ions; D008387:Marine Toxins / Q000494:pharmacology*; D009498:Neurotoxins / Q000494:pharmacology*; D035964:Oxocins; D011901:Ranvier's Nodes / Q000187:drug effects* / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D000095702:Polyether Toxins
chemical_list: D002412:Cations; D002922:Ciguatoxins; D003064:Cnidarian Venoms; D007477:Ions; D008387:Marine Toxins; D009498:Neurotoxins; D035964:Oxocins; D015222:Sodium Channels; C012307:equinatoxin; C053342:brevetoxin; D000095702:Polyether Toxins