title: Diverse vacA allelic types of Helicobacter pylori in Korea and clinical correlation.
abstract: Helicobacter pylori has a diversity of vacA allelic types. The purpose of this study was to correlate the vacA status and the clinical outcome. After constructing specific primers for the vacA signal sequence, H. pylori-positive antral biopsy specimens were examined for the vacA status in 25 gastric ulcers, 31 duodenal ulcers, 22 gastric cancers, 42 chronic gastritis, and 8 gastroduodenal ulcers. The relationship between the vacA allele and the clinical disease was examined. The vacA genotype s1c/m1 is predominant in Korea (71/128, 55.5%). Other strains including s1b or s2 were not found in this study. s1c/m1 was more prominent in duodenal ulcers, than in gastric ulcers (p=0.041) and cancer (p=0.029). Seven out of 8 patients with gastric and coexistent duodenal ulcers had the s1c/m1 allele. No statistical differences in the positive rates of the s1a/m1, s1a/m2, and s1c/m2 alleles among the disease groups were found. In conclusion, s1c/m1 is the main vacA allele in Korea and it is particularly associated with duodenal ulcers.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yon Ho
authors.initials: YH
authors.lastname: Choe
authors.forename: Pum Soo
authors.initials: PS
authors.lastname: Kim
authors.forename: Don Haeng
authors.initials: DH
authors.lastname: Lee
authors.forename: Hyung Kil
authors.initials: HK
authors.lastname: Kim
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Yong Woon
authors.initials: YW
authors.lastname: Shin
authors.forename: Tae Sook
authors.initials: TS
authors.lastname: Hwang
authors.forename: Hyeon Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sun Uk
authors.initials: SU
authors.lastname: Song
authors.forename: Mi Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000595:Amino Acid Sequence / Q000235:genetics; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002648:Child; D016481:Helicobacter Infections / Q000503:physiopathology / Q000821:virology; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D007723:Korea; D008875:Middle Aged; D008969:Molecular Sequence Data
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori