Rapid parallel synthesis of combinatorial libraries of substituted 3-thio-1,2,4-triazoles and 2-thioimidazoles.
Combinatorial libraries of substituted 3-thio-1,2,4-triazoles and 2-thioimidazoles were synthesized in good yield by alkylation of the products via the reaction of isothiocyanates and carboxylic acid hydrazides or beta-aminoketones, respectively. A total of 275 3-thio-1,2,4-triazoles and 283 2-thioimidazoles were synthesized out of the attempted 288 in each case. Most the yields were between 45% and 98%, and all the compounds synthesized were purified to >85% purity. Variations in yields revealed no definitive trends and were mainly attributed to bulky alkylating agents used and the plate well location of the reaction mixtures.
Theoclitou
Maria-Elena
ME
Bristol-Myers Squibb, Pharma Research Laboratories, 4570 Executive Drive, San Diego, California 92121, USA. Maria-Elena.Thouclitou@dupontpharma
Delaet
Nancy G J
NG
Robinson
Leslie A
LA
D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D007093:Imidazoles; D014230:Triazoles