Treatment of cancer with cryochemotherapy.
Cryosurgery employs freezing to destroy solid tumours. However, frozen cells can survive and cause cancer recurrence. Bleomycin, an anticancer drug with a huge intrinsic cytotoxicity is normally not very effective because it is nonpermeant. We report that freezing facilitates bleomycin penetration into cells making it toxic to cryosurgery surviving cells at concentrations that are non-toxic systemically.
Mir
L M
LM
FRE 2530 CNRS, Institut Gustave Roussy, PR II, 39, rue Camille Desmoulins, F-94805 Villejuif Cédex, France. luismir@igr.fr
Rubinsky
B
B
D000818:Animals; D001761:Bleomycin / Q000737:chemistry / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D003080:Cold Temperature; D005615:Freezing; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
D001761:Bleomycin