title: Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water.
abstract: 14C-labeled flumequine was administered as a single oral (5 mg kg(-1), 86 microCi kg(-1)) or intravenous (5 mg kg(-1), 82 microCi kg(-1)) dose to Atlantic salmon Salmo salar held in sea water or in fresh water. The absorption, tissue distribution and elimination were determined by means of liquid scintillation counting and whole-body autoradiography. The drug was rapidly absorbed and extensively distributed in all groups of fish. Radiolabeled compound was present in blood and muscle for more than 8 wk in the freshwater groups. In the seawater groups, however, no radioactivity was detected in the blood and muscle after 4 d and 2 wk, respectively. It was concluded that flumequine was eliminated at a substantially higher rate from Atlantic salmon in sea water than in fresh water.
authors.affiliation: Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, Oslo. sidsel.sohlberg@veths.no
authors.forename: Sidsel
authors.initials: S
authors.lastname: Sohlber
authors.forename: Kristian
authors.initials: K
authors.lastname: Ingebrigtsen
authors.forename: Magne K
authors.initials: MK
authors.lastname: Hansen
authors.forename: William L
authors.initials: WL
authors.lastname: Hayton
authors.forename: Tor Einar
authors.initials: TE
authors.lastname: Horsberg
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001345:Autoradiography / Q000662:veterinary; D001682:Biological Availability; D024841:Fluoroquinolones; D005618:Fresh Water; D007275:Injections, Intravenous / Q000662:veterinary; D011807:Quinolizines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020317:Salmo salar / Q000378:metabolism*; D012588:Scintillation Counting / Q000662:veterinary; D012623:Seawater; D014018:Tissue Distribution
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011807:Quinolizines; C012976:flumequine