title: [Evaluation of preoperative simultaneous radiochemotherapy combined with carboplatin and tegafur.uracil].
abstract: We performed preoperative radiochemotherapy including local irradiation with total dose of 40 Gy along with concomitant combination chemotherapy with carboplatin and tegafur.uracil for 11 head and neck squamous cell carcinomas and evaluated the clinical and histopathological effects as well as the side effects. Seventy-three percent of patients accomplished significant clinical effects equal to or more than PR and significant histopathological effects in surgically resected tissues. Side effects were seen in only one patient with severe hypoleukocytemia, no patients with renal dysfunction, and 34% of patients with severe oral mucositis. These results suggest that our radiochemotherapy may be useful for preoperative treatment for patients with locally advanced head and neck squamous cell carcinomas.
authors.affiliation: Dept. of Otolaryngology, Asahikawa Medical College.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Katayama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nonaka
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Bandoh
authors.forename: Masanobu
authors.initials: M
authors.lastname: Imada
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Harabuchi
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D003131:Combined Modality Therapy / Q000009:adverse effects; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D005641:Tegafur; D014498:Uracil; D016190:Carboplatin