[Growth of insulin-producing beta cells. Perhaps a new way to treat type 1 diabetes].
Insulin dependent diabetes mellitus (type 1-diabetes) results from a selective destruction of the insulin producing beta cells and a limited capacity of the remaining cells to regenerate in a compensatory manner. Increased knowledge of the factors involved in the regulation of beta-cell growth may lead to new ways of forming beta cells that in combination with selective immunosuppression could be used for treatment of type 1 diabetes. Physiological and pathophysiological conditions that induce beta-cell growth, different factors that have been implicated to regulate these processes and future perspectives concerning treatment of type 1 diabetes by expanding the beta-cell mass is discussed in this review article.
Annerén
Cecilia
C
Department of Molecular and Cellular Biology, Harvard University, Cambridge, USA. anneren@fas.harvard.edu
D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology* / Q000276:immunology / Q000473:pathology; D016381:Islets of Langerhans Transplantation; D011505:Protein-Tyrosine Kinases / Q000502:physiology
D006133:Growth Substances; D011505:Protein-Tyrosine Kinases