title: Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000).
abstract: A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
authors.affiliation: Department of Dermatology, Amersham Hospital, Bucks, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: Wilkinson
authors.forename: S
authors.initials: S
authors.lastname: Shaw
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: F M
authors.initials: FM
authors.lastname: Brandao
authors.forename: D P
authors.initials: DP
authors.lastname: Bruynzeel
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.forename: J M G
authors.initials: JM
authors.lastname: Camarasa
authors.forename: T L
authors.initials: TL
authors.lastname: Diepgen
authors.forename: G
authors.initials: G
authors.lastname: Ducombs
authors.forename: P J
authors.initials: PJ
authors.lastname: Frosch
authors.forename: A
authors.initials: A
authors.lastname: Goossens
authors.forename: J-M
authors.initials: JM
authors.lastname: Lachappelle
authors.forename: A
authors.initials: A
authors.lastname: Lahti
authors.forename: T
authors.initials: T
authors.lastname: Menné
authors.forename: S
authors.initials: S
authors.lastname: Seidenari
authors.forename: A
authors.initials: A
authors.lastname: Tosti
authors.forename: J E
authors.initials: JE
authors.lastname: Wahlberg
mesh_terms: D000485:Allergens; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005060:Europe / Q000453:epidemiology; D005557:Formaldehyde / Q000009:adverse effects; D006801:Humans; D009570:Nitriles / Q000009:adverse effects; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D013844:Thiazoles / Q000009:adverse effects
chemical_list: D000485:Allergens; D009570:Nitriles; D011310:Preservatives, Pharmaceutical; D013844:Thiazoles; D005557:Formaldehyde; C011506:2-methyl-4-isothiazolin-3-one; C011421:5-chloro-2-methyl-4-isothiazolin-3-one; C039411:1,2-dibromo-2,4-dicyanobutane