title: The progress in mechanism of selenoprotein biosynthesis.
abstract: As the twenty-first amino acid, selenocysteine can be co-translationally incorporated into the polypeptide chain at UGA codon in the coding region of selenoprotein mRNA. The incorporation of selenocysteine needs a cis-acting element SECIS and four gene products: SelA, SelB, SelC and SelD. The position of SECIS in the mRNA of prokaryote and its structural features are greatly different from that of eukaryote. The researchers have made exploration in selenoprotein engineering by virtue of the mechanism of selenocysteine incorporation in Escherichia coli.
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130023, China. gmluo@mail.jlu.edu.cn
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Mu
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Li
authors.forename: Gang-Lin
authors.initials: GL
authors.lastname: Yan
authors.forename: Gui-Min
authors.initials: GM
authors.lastname: Luo
mesh_terms: D001483:Base Sequence; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D051140:Selenoproteins
chemical_list: D011506:Proteins; D012333:RNA, Messenger; D051140:Selenoproteins