The relationship between cortical activation and perception investigated with invisible stimuli.
The aim of this work was to study the relationship between cortical activity and visual perception. To do so, we developed a psychophysical technique that is able to dissociate the visual percept from the visual stimulus and thus distinguish brain activity reflecting the perceptual state from that reflecting other stages of stimulus processing. We used dichoptic color fusion to make identical monocular stimuli of opposite color contrast "disappear" at the binocular level and thus become "invisible" as far as conscious visual perception is concerned. By imaging brain activity in subjects during a discrimination task between face and house stimuli presented in this way, we found that house-specific and face-specific brain areas are always activated in a stimulus-specific way regardless of whether the stimuli are perceived. Absolute levels of cortical activation, however, were lower with invisible stimulation compared with visible stimulation. We conclude that there is no terminal "perceptual" area in the visual brain, but that the brain regions involved in processing a visual stimulus are also involved in its perception, the difference between the two being dictated by a higher level of activity in the specific brain region when the stimulus is perceived.
Moutoussis
K
K
Wellcome Department of Imaging Neuroscience, University College London, London WC1E 6BT, United Kingdom.
Zeki
S
S
D003118:Color Perception / Q000502:physiology; D003119:Color Perception Tests; D003627:Data Interpretation, Statistical; D004192:Discrimination, Psychological; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D014793:Visual Cortex / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*