title: Prospective study of measles in hospitalized, human immunodeficiency virus (HIV)-infected and HIV-uninfected children in Zambia.
abstract: Measles in persons coinfected with human immunodeficiency virus (HIV) has been reported to be unusual in its presentation and frequently fatal. To determine the effect of HIV coinfection on the clinical features and outcome of measles, a prospective study of hospitalized children with measles was conducted between January 1998 and October 2000 in Lusaka, Zambia. One-sixth (17%) of 546 children hospitalized with laboratory-confirmed measles were coinfected with HIV. One-third of the HIV-infected children hospitalized with confirmed measles were <9 months old, compared with 23% of HIV-uninfected children (P=.03). Few differences in clinical manifestations, complications, or mortality were found between HIV-infected and HIV-uninfected children with measles. HIV-infected children constitute a significant proportion of children hospitalized with measles in countries with high HIV prevalence and are more likely to be younger than the age for routine measles immunization.
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, School of Medicine, Johns Hopkins University, Baltimore, MD 21205-2179, USA. wmoss@jhsph.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Moss
authors.forename: Mwaka
authors.initials: M
authors.lastname: Monze
authors.forename: Judith J
authors.initials: JJ
authors.lastname: Ryon
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Quinn
authors.forename: Diane E
authors.initials: DE
authors.lastname: Griffin
authors.forename: Felicity
authors.initials: F
authors.lastname: Cutts
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D002673:Child, Hospitalized; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D018023:HIV Seronegativity / Q000276:immunology; D006679:HIV Seropositivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D018655:Lymphocyte Count; D008297:Male; D008457:Measles / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D008458:Measles Vaccine / Q000627:therapeutic use; D008459:Measles virus / Q000276:immunology; D011446:Prospective Studies; D016176:T-Lymphocyte Subsets / Q000473:pathology; D015024:Zambia / Q000453:epidemiology
chemical_list: D008458:Measles Vaccine