Mechanisms of in situ activation for DNA-targeting antitumor agents.
Wolkenberg
Scott E
SE
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Boger
Dale L
DL
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000187:drug effects* / Q000378:metabolism; D000080890:Duocarmycins; D006801:Humans; D007211:Indoles; D007933:Leucomycins / Q000378:metabolism; D009690:Nucleic Acid Conformation; D011760:Pyrrolidinones / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D004273:DNA, Neoplasm; D000080890:Duocarmycins; D007211:Indoles; D007933:Leucomycins; D011760:Pyrrolidinones; C060648:duocarmycin B1; C018782:CC 1065; C058289:duocarmycin A