title: Effects of Roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes.
abstract: BACKGROUND
  The macrolide antibiotic roxithromycin is effective against acne associated with inflammation, but the mechanism by which this is achieved has not been clarified.
  
  
  OBJECTIVE
  We studied the effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes in vitro.
  
  
  RESULTS
  Roxithromycin significantly inhibited the production of lipase and neutrophil chemotactic factor by P. acnes at a concentration one eighth of the MIC, at which the growth curve of P. acnes is not affected.
  
  
  CONCLUSIONS
  One mechanism of the effectiveness of roxithromycin in acne therapy is thought to be the inhibition of bacterial lipase and neutrophil chemotactic factor production by P. acnes.
authors.affiliation: Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan. akamatsu@fujita-hu.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Akamatsu
authors.forename: T
authors.initials: T
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Horio
mesh_terms: D000152:Acne Vulgaris / Q000378:metabolism* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000378:metabolism*; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D008049:Lipase / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000145:classification / Q000187:drug effects* / Q000378:metabolism; D015575:Roxithromycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D016209:Interleukin-8; D015575:Roxithromycin; D008049:Lipase