title: A patient with a severe chronic airway obstruction and preserved exercise capacity (a case report).
abstract: We report a patient with chronic obstructive pulmonary disease (COPD) in whom severe lung function disorders are combined with completely preserved exercise capacity. We assessed the exercise capacity of a 44-year-old man (height 155 cm, BMI 19.6 kg.m-2, FEV1%pred. = 30.9%, FRC%pred. = 158%, KCO%pred. = 46.2%, PaO2 = 64.0 mmHg, Medical Research Council Dyspnea scale = 1, Baseline Dyspnea Index = 10) by the 6-minute walking distance test (6MWD) and the symptom-limited cardiopulmonary exercise test (CPET) on a treadmill using the Bruce protocol. The patient was able to walk 667 meters in the test and achieved peak relative oxygen consumption (VO2/kg) of 21.9 mL.min-1.kg-1. We attribute the preserved exercise capacity of the patient to the combined beneficial effect of the following factors: 1. Efficient extraction of the hemoglobin-transported oxygen from the alveoli (P50 = 3.10 kPa). 2. Optimal right ventricle remodelling with mild hypertrophy, without dilatation and congestion. 3. Hypoxic normoxemia without polyglobulia, resulting in good rheologic properties of blood. 4. A preserved locomotory activity of the patient. Such a combination of severe lung function disorders with mildly pronounced dyspnea and preserved exercise capacity supports the concept that the function profile of COPD patients is multidimensional and therefore such patients should have a complete assessment of their disability condition.
authors.affiliation: Medical University, Department of Pneumology, 15A Vassil Aprilov St., 4000 Plovdiv, Bulgaria.
authors.forename: V A
authors.initials: VA
authors.lastname: Hodzhev
authors.forename: S S
authors.initials: SS
authors.lastname: Kostianev
authors.forename: B I
authors.initials: BI
authors.lastname: Marinov
authors.forename: Z N
authors.initials: ZN
authors.lastname: Galabov
authors.forename: D H
authors.initials: DH
authors.lastname: Iluchev
authors.forename: P V
authors.initials: PV
authors.lastname: Mandulova
mesh_terms: D000328:Adult; D004417:Dyspnea / Q000503:physiopathology; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*