Hepatocyte growth factor in cerebrospinal fluid in neurologic disease.
OBJECTIVE
To investigate hepatocyte growth factor (HGF) concentration in cerebrospinal fluid (CSF) in neurologic disease.


METHODS
We determined CSF concentration of HGF with human-HGF-specific enzyme-linked immunosorbent assays (ELISA) in 121 patients: Alzheimer's disease (AD) (33), amyotrophic lateral sclerosis (ALS) (10), Parkinson's disease (PD) (5), progressive supranuclear palsy (PSP) (3), spinocerebellar degeneration (7), acute disseminating encephalomyelitis (ADEM) (6), human T-lymphotropic virus-1 (HTLV-1)-associated myelopathy (HAM) (6), multiple sclerosis (MS) (7), aseptic meningitis (AM) (12), and peripheral neuropathy and myopathy as control diseases (32).


RESULTS
HGF concentrations in CSF were significantly higher with diseases of the central nervous system (CNS) than control diseases and were slightly higher with AD than other neurodegenerative diseases. Values were highest with ADEM but decreased during corticosteroid treatment. We found no relationship between HGF in CSF and CSF cells or protein, immunoglobulin index, or Q albumin.


CONCLUSIONS
It is suggested that high concentrations of HGF in CSF may be partially related to CNS pathology, especially to demyelinating disease.
Tsuboi
Y
Y
Department of Neuroloy, Mayo Clinic, Jacksonville, Fl 32224, USA. tsuboi.yoshio@mayo.edu
Kakimoto
K
K
Akatsu
H
H
Daikuhara
Y
Y
Yamada
T
T
D000328:Adult; D000368:Aged; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid*; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid*; D005260:Female; D017228:Hepatocyte Growth Factor / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000134:cerebrospinal fluid; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid
D017228:Hepatocyte Growth Factor