Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells.
Bryonia alba roots (BAR) are widely used as an adaptogenic and restorative drug with immunomodulatory and stress-protective properties that increase the non-specific resistance of an organism toward harmful stimuli. Potential genotoxic activity of aqueous and methanol extracts of BAR was studied on human normal (lymphocytes) and transformed (HeLa and Caco-2) cells using single cell gel electrophoresis (the comet assay). The results obtained did not show any evidence of genotoxic effects of BAR.
Nersesyan
A K
AK
Laboratory of Carcinogenesis, Cancer Research Center, Yerevan, Armenia. genetik@ysu.am
Collins
A R
AR
D002470:Cell Survival / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004249:DNA Damage; D006367:HeLa Cells; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000633:toxicity*; D018517:Plant Roots; D027824:Rosaceae; D014407:Tumor Cells, Cultured
D009153:Mutagens; D010936:Plant Extracts