title: Radiotherapy-induced cerebral abnormalities in patients with low-grade glioma.
abstract: Abnormalities on CT or MRI and neuropsychological performance in patients with low-grade glioma, with (n = 23) or without (n = 16) prior cerebral radiotherapy, were evaluated. Cerebral atrophy was observed in 14 of 23 patients (61%) treated with prior radiotherapy, and in 1 of 16 patients (6%) without prior radiotherapy. White matter abnormalities were observed in six patients, all of whom were treated with prior radiotherapy. These radiologic cerebral abnormalities correlated with cognitive performance.
authors.affiliation: Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. TJ.Postma@vumc.nl
authors.forename: T J
authors.initials: TJ
authors.lastname: Postma
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: C C P
authors.initials: CC
authors.lastname: Verstappen
authors.forename: J E C
authors.initials: JE
authors.lastname: Bromberg
authors.forename: M
authors.initials: M
authors.lastname: Swennen
authors.forename: J A
authors.initials: JA
authors.lastname: Langendijk
authors.forename: M J B
authors.initials: MJ
authors.lastname: Taphoorn
authors.forename: P
authors.initials: P
authors.lastname: Scheltens
authors.forename: B J
authors.initials: BJ
authors.lastname: Slotman
authors.forename: H M
authors.initials: HM
authors.lastname: van der Ploeg
authors.forename: N K
authors.initials: NK
authors.lastname: Aaronson
authors.forename: J J
authors.initials: JJ
authors.lastname: Heimans
mesh_terms: D000328:Adult; D001284:Atrophy; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D002540:Cerebral Cortex / Q000473:pathology*; D003071:Cognition; D005260:Female; D005910:Glioma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*