title: Epimerization study on [18f]FDG produced by an alkaline hydrolysis on solid support under stringent conditions.
abstract: Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and finally hydrolyzed within the cartridge, at room temperature, using sodium hydroxide. The present study demonstrated that no epimerization of [18F]FDG to [18F]FDM occurs even when 12 N NaOH is used and when the hydrolysis time is extended up to 1 h. The alkaline hydrolysis on solid support appears to be a simple method leading to [18F]FDG with high purity.
authors.affiliation: Coincidence Technologies s.a., Parc Scientifique du Sart Tilman, Liège, Belgium. mos@coincidence.com
authors.forename: C
authors.initials: C
authors.lastname: Mosdzianowsk
authors.forename: C
authors.initials: C
authors.lastname: Lemaire
authors.forename: F
authors.initials: F
authors.lastname: Simoens
authors.forename: J
authors.initials: J
authors.lastname: Aerts
authors.forename: J L
authors.initials: JL
authors.lastname: Morelle
authors.forename: A
authors.initials: A
authors.lastname: Luxen
mesh_terms: D019788:Fluorodeoxyglucose F18 / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007536:Isomerism; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012972:Sodium Hydroxide
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D012972:Sodium Hydroxide