title: Association between serum apolipoprotein C(II) concentration and coronary heart disease.
abstract: BACKGROUND
  Apolipoprotein (Apo) C(II) plays an essential role in the metabolism of triglyceride-rich lipoproteins (TRLs) by activating lipoprotein lipase. Several studies have suggested that an abnormal concentration of Apo C(II) may serve as a marker for deficient TRL metabolism, a possible cause of coronary heart disease (CHD). The aim of the present study was to evaluate the association between Apo C(II) and the presence of CHD.
  
  
  METHODS
  A case-control study comparing 352 CHD patients and 395 controls was performed. Demographic, clinical, and laboratory characteristics were determined.
  
  
  RESULTS
  The CHD patients had a higher mean concentration of Apo C(II) than controls (5.3 mg/dl compared with 4.2 mg/dl, P < 0.001). Elevated serum Apo C(II) concentration was associated with CHD presence after adjustment for cardiovascular risk factors. The risk factor-adjusted odds ratio (OR) for CHD was 1.60 (95% CI: 1.31-1.94) per 1 mg/dl increment in Apo C(II), compared with a risk factor-adjusted OR of 1.05 (95% CI: 0.85-1.32) per 40 mg/dl increment in triglyceride concentration.
  
  
  CONCLUSIONS
  Increased serum concentration of Apo C(II) may represent a more sensitive marker of CHD than high serum concentration of triglycerides. Confirmation in cohort studies in required to establish or refute the role of elevated serum Apo C(II) as a risk factor for CHD.
authors.affiliation: Division of Epidemiology and Preventive Medicine, Sackler Medical Faculty, Tel Aviv University, Israel.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Gerber
authors.forename: Uri
authors.initials: U
authors.lastname: Goldbourt
authors.forename: Hofit
authors.initials: H
authors.lastname: Cohen
authors.forename: Dror
authors.initials: D
authors.lastname: Harats
mesh_terms: D000328:Adult; D000368:Aged; D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000097:blood*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D014280:Triglycerides