title: A mark in the core: silence no more!
abstract: The histone modification repertoire has recently been expanded. Dot1p is a new type of methyltransferase that methylates lysine 79 in the histone H3 core only in its nucleosomal context and has a possible role in marking open chromatin regions.
authors.affiliation: Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, UK.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Varga-Weisz
authors.forename: Jacob Z
authors.initials: JZ
authors.lastname: Dalgaard
mesh_terms: D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D020868:Gene Silencing; D011495:Histone-Lysine N-Methyltransferase; D006657:Histones / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D006657:Histones; D009687:Nuclear Proteins; D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins; C416235:Dot1 protein, S cerevisiae; D011495:Histone-Lysine N-Methyltransferase; D008239:Lysine