[Clinical study of various growth factors on the improvement of impaired healing ulcers in patients with diabetic disease].
OBJECTIVE
To investigate clinical effects and possible mechanisms of various growth factors on impaired healing ulcers of patients with diabetic disease.


METHODS
Seventy-eight patients were divided into three groups; saline control, epidermal growth factor(EGF) experimental group, and platelet-derived wound healing factor (PDWHF) experimental group. General healing conditions, wound closing index, healing rates and histological changes of the patient's ulcer wound were observed during 1-8 weeks after treatment.


RESULTS
The wound closing index and healing rate of ulcers were significantly increased in the EGF and PDWHF experimental groups compared with the control group, while the angiogenesis, fibroblast hyperplasia, and collagen deposit were more obvious in EGF and PDWHF experimental groups than that of control group. The promoting effects on wound healing in PDWHF experimental group were better than in EGF group.


CONCLUSIONS
It suggests that local application of certain growth factor alone or various growth factors together is an effective method to improve the condition of impaired healing of diabetic ulcers.
Feng
J
J
Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongquing, P. R. China 400042.
Du
W H
WH
Wang
J
J
D000368:Aged; D017719:Diabetic Foot / Q000628:therapy*; D004815:Epidermal Growth Factor / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D010982:Platelet-Derived Growth Factor; D004815:Epidermal Growth Factor