[Ischemic preconditioning reduces lung ischemia reperfusion injury in vivo rabbits].
Thirty male Japanese white rabbits were randomized into two groups. Fifteen rabbits were treated with ischemic preconditioning(their left lung hilus clamped for 10 min and released for 15 min; Group IP). Fifteen rabbits were not treated with ischemic preconditioning(Group C). Then the left lung hilus of both groups were occlused for 60 min and reperfused for 60 min. The results were that after 60 min of reperfusion, in Group IP, the contents of angiotensin II (Ang II) and artery oxygen tension(PaO2) in blood samples and the contents of superoxide dismutase in lung tissue were significantly higher, while the mean pulmonary artery pressure in blood samples, the wet/dry ratio and malondialdehyde content in lung tissue were significantly lower than those in Group C; Histological findings showed less damage in Group IP. It is suggested that lung ischemic preconditioning can reduce normothermic rabbit lung ischemia-reperfusion injury.
Li
G
G
Department of Cardiothoracic Surgery, Hunan Medical University, Changsha 410008.
Chen
S
S
Lu
E
E
Hu
T
T
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous; D019194:Ischemic Preconditioning; D008168:Lung / Q000098:blood supply*; D008297:Male; D010100:Oxygen / Q000378:metabolism; D011817:Rabbits; D011897:Random Allocation; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
D000804:Angiotensin II; D013482:Superoxide Dismutase; D010100:Oxygen