title: Growth problems and growth hormone treatment in children with cystic fibrosis.
abstract: Children with cystic fibrosis (CF) typically demonstrate poor linear growth and, despite aggressive nutritional supplementation, suboptimal weight gain. Growth velocity may be particularly blunted during puberty, a finding that occurs independently of clinical status or sex steroid levels. Several studies indicate that growth hormone (GH) treatment may be associated with significant improvement in both height velocity and weight gain in children with CF. These findings may translate into improvements in clinical status. In our experience, improved growth and weight status have been associated with fewer hospitalizations, fewer antibiotic courses, and improved pulmonary function. A large multicenter trial is currently underway to assess the effect of long-term therapy with GH on the quality of life and pulmonary status.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical School, Dallas 75390-9063, USA. dana.hardin@utsouthwestern.edu
authors.forename: Dana S
authors.initials: DS
authors.lastname: Hardin
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D013006:Growth Hormone