Candidate genes for atopic asthma: current results from genome screens.
Atopic asthma is one of the most common childhood diseases in developed countries. Asthma is characterized by reversible airway obstruction, bronchial hyper-responsiveness, and airway inflammation. Atopy in childhood is considered the strongest predisposing factor for asthma. The etiology of asthma is complex and is thought to involve the interaction of multiple genes and a variety of environmental factors such as allergens and viral and bacterial infections. To identify genes conferring susceptibility for asthma and atopy, many genome-wide screens for asthma and its associated traits have now been carried out, and genetic linkage has been consistently identified in several regions. Several independent genome-wide screens found regions of linkage with asthma on chromosomes 5, 6, 11, 12, 13, 16 and 19, identifying candidate susceptibility genes including FCER1B, the IL-4 gene cluster, TNFalpha, HLA loci and others. However, the evidence for linkage is still only suggestive for most regions. In an effort to clarify the mechanism underlying the development of asthma, further studies utilizing new technologies and data from the Human Genome Project are ongoing. It is hoped that this accumulation of data will lead to improved genetic testing and assist in the development of new drugs.
Noguchi
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Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.
Arinami
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D001249:Asthma / Q000235:genetics* / Q000276:immunology; D019742:Chemokines, CC; D002648:Child; D015894:Genome, Human; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D054401:Receptors, CCR8; D019707:Receptors, Chemokine / Q000235:genetics; D018123:Receptors, Interleukin / Q000235:genetics; D053651:Receptors, Interleukin-9
C103330:CCR8 protein, human; D019742:Chemokines, CC; C508045:IL9R protein, human; D011948:Receptors, Antigen, T-Cell; D054401:Receptors, CCR8; D019707:Receptors, Chemokine; D018123:Receptors, Interleukin; D053651:Receptors, Interleukin-9