title: [Cerebral glucose metabolism in Down syndrome using positron emission tomography].
abstract: Resting cerebral glucose metabolism was assessed by PET using FDG in eleven Down syndrome (DS) patients. Standardized uptake values (SUV) were determined on a pixel by pixel basis from the measured tissue FDG-activity data. The results showed that the mean value of the global FDG-uptake in the DS patients was not significantly different from the one obtained in the control group consisting of children and young adults. The standard deviation of SUV, however, was much higher in the DS group in almost all regions. The statistical parametric mapping (SPM) method was applied to compare the relative cerebral FDG accumulation pattern of the populations. Six regions (clusters) were found in which the glucose-uptake was higher in the DS patients than in the control group. The anatomical localization of these clusters was based on MRI investigations and brain-atlas technique.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Gyermekklinika, Debrecen. balogh@gyermek.dote.hu
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Balogh
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lengyel
authors.forename: Miklós
authors.initials: M
authors.lastname: Emri
authors.forename: Edit
authors.initials: E
authors.lastname: Szikszai
authors.forename: Olga
authors.initials: O
authors.lastname: Esik
authors.forename: József
authors.initials: J
authors.lastname: Kollár
authors.forename: Judit
authors.initials: J
authors.lastname: Sikula
authors.forename: Lajos
authors.initials: L
authors.lastname: Trón
authors.forename: Eva
authors.initials: E
authors.lastname: Oláh
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose