title: Randomised, controlled trial of the efficacy and safety of adapalene gel 0.1% and tretinoin cream 0.05% in patients with acne vulgaris.
abstract: BACKGROUND
  Previous clinical trials have shown that adapalene gel produces less irritation than tretinoin gels and tretinoin 0.025% cream. Short term results have shown that adapalene is less irritating than tretinoin gels and creams. This study is the first to compare the 0.1% formulation of adapalene gel with the 0.05% strength of tretinoin cream in a formal clinical trial.
  
  
  OBJECTIVE
  To investigate the efficacy and tolerability of adapalene gel 0.1% compared with tretinoin cream 0.05% in patients with mild-to-moderate acne vulgaris.
  
  
  METHODS
  Ten-week, multicentre, randomised, investigator-masked, active-controlled, parallel group study in 409 patients with acne vulgaris.
  
  
  RESULTS
  Adapalene gel 0.1% demonstrated equivalent efficacy in reduction of acne lesion counts and global improvement of acne severity over 10 weeks' treatment and was significantly better tolerated than tretinoin cream 0.05% in terms of erythema, dryness, desquamation and stinging/burning.
  
  
  CONCLUSIONS
  Adapalene gel 0.1% showed equivalent efficacy and was significantly better tolerated than tretinoin cream 0.05% in patients with mild-to-moderate acne vulgaris.
authors.affiliation: Departement of Dermatology, General Infirmary, Leeds, UK.
authors.forename: William J
authors.initials: WJ
authors.lastname: Cunliffe
authors.forename: F William
authors.initials: FW
authors.lastname: Danby
authors.forename: Frank
authors.initials: F
authors.lastname: Dunlap
authors.forename: Michael H
authors.initials: MH
authors.lastname: Gold
authors.forename: David
authors.initials: D
authors.lastname: Gratton
authors.forename: Alan
authors.initials: A
authors.lastname: Greenspan
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000068816:Adapalene; D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D002648:Child; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003879:Dermatologic Agents; D007641:Keratolytic Agents; D009281:Naphthalenes; D009824:Ointments; D000068816:Adapalene; D014212:Tretinoin