Prevalence of Helicobacter pylori in Sri Lanka as determined by PCR.
Fifty-seven Sinhalese patients were investigated for the presence of Helicobacter pylori by PCR. A prevalence of 70.1%, with 47.5% positive for cagA, was demonstrated. The most common vacA allele was s1am1. There was no significant association between either the s1 allele or the cagA allele and severe gastroduodenal disease. There was an association between the s1 allele and the cagA locus.
Fernando
N
N
Department of Bacteriology, Royal Free & University College London Medical School, London, United Kingdom.
Holton
J
J
Vaira
D
D
DeSilva
M
M
Fernando
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D017931:DNA Primers / Q000235:genetics; D004381:Duodenal Ulcer / Q000382:microbiology; D004415:Dyspepsia / Q000382:microbiology; D005260:Female; D005756:Gastritis / Q000382:microbiology; D005798:Genes, Bacterial; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013188:Sri Lanka / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000382:microbiology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D017931:DNA Primers; C080866:cagA protein, Helicobacter pylori