title: A new device for stereotactic CT-guided biopsy of the canine brain: design, construction, and needle placement accuracy.
abstract: An inexpensive device was created for computed tomographic (CT)-guided stereotactic biopsy of the canine brain. The accuracy of the device was tested using 16, formalin-perfused, canine head specimens. For each dog, a 6-inch biopsy needle was guided into pituitary gland and caudate nucleus targets. Needle tracks were measured using the CT computer and infused with tissue staining solution. Hit success and actual needle track lengths were determined from sliced brain specimens. The device enabled accurate orientation and placement of the canine head in the slice plane, such that progressive penetration of the biopsy needle could be monitored. The caudate nucleus was hit 12/16 times (75% accuracy) and the pituitary gland 15.5/16 times (98.6% accuracy). Hit proportions for the two targets did not differ (P < 0.05). A significant difference was found between CT and actual track length for both targets (P < 0.01). This was attributed to incomplete staining of the bevel portion of the needle track.
authors.affiliation: Department of Small Animal Clinical Sciences, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.
authors.forename: Alain
authors.initials: A
authors.lastname: Giroux
authors.forename: Jeryl C
authors.initials: JC
authors.lastname: Jones
authors.forename: Jan Helge
authors.initials: JH
authors.lastname: Bøhn
authors.forename: Robert B
authors.initials: RB
authors.lastname: Duncan
authors.forename: Don R
authors.initials: DR
authors.lastname: Waldron
authors.forename: Karen R
authors.initials: KR
authors.lastname: Inzana
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000662:veterinary; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D002421:Caudate Nucleus; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D004285:Dogs; D004867:Equipment Design; D010902:Pituitary Gland; D013238:Stereotaxic Techniques / Q000295:instrumentation / Q000592:standards / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000592:standards / Q000662:veterinary*