title: Heritability estimates for the constitutional levels of the collectins mannan-binding lectin and lung surfactant protein D. A study of unselected like-sexed mono- and dizygotic twins at the age of 6-9 years.
abstract: The collectins mannan-binding lectin (MBL) and lung surfactant protein D (SP-D) play a significant role in innate immunity. Structural as wells as promoter variants are known for MBL and different alleles correlate with low MBL concentrations in serum and predispose to infectious diseases. Structural variants are also known for SP-D but these have not been linked to disease states. The aim of the present study was to provide heritability estimates for the constitutional levels of MBL and SP-D in children. A population of 26 monozygotic (MZ) and 36 dizygotic (DZ) like-sexed twin pairs aged 6-9 years was studied. Intraclass correlations were significantly higher in MZ than in DZ twins, indicating substantial genetic influence on both MBL and SP-D levels. Biometric model fitting showed that the estimated heritability was 0.96 (95% CI 0.92-0.97) for MBL with the presence of non-additive genetic factors and non-shared environmental factors and 0.91 (95% CI 0.83-0.95) for SP-D with additive genetic and non-shared environmental factors. The data indicate quantitatively very strong genetic dependence for the serum levels of both MBL and SP-D.
authors.affiliation: Department of Paediatrics, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Steffen.Husby@ouh.fyns-amt.dk
authors.forename: Steffen
authors.initials: S
authors.lastname: Husby
authors.forename: Anne Maria
authors.initials: AM
authors.lastname: Herskind
authors.forename: Jens Christian
authors.initials: JC
authors.lastname: Jensenius
authors.forename: Uffe
authors.initials: U
authors.lastname: Holmskov
mesh_terms: D001699:Biometry; D002352:Carrier Proteins / Q000097:blood / Q000235:genetics*; D002648:Child; D037222:Collectins; D005260:Female; D006023:Glycoproteins / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants / Q000097:blood / Q000235:genetics*; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D002352:Carrier Proteins; D037222:Collectins; D006023:Glycoproteins; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants