title: Effect of tear film break-up on higher-order aberrations measured with wavefront sensor.
abstract: OBJECTIVE
  To investigate whether optical wavefront aberrations vary with tear film break-up.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Higher-order aberrations were examined for 20 eyes of 20 normal subjects with a Hartmann-Shack wavefront sensor before and after tear film break-up.
  
  
  RESULTS
  Higher-order aberrations for photopic vision (central 4 mm diameter) after tear film break-up increased 1.44 fold compared to higher-order aberrations before tear film break-up (P =.001, paired t-test). Higher-order aberrations after tear film break-up for scotopic vision (central 6 mm diameter) were also 1.23 times higher than those before break-up (P =.005, paired t-test).
  
  
  CONCLUSIONS
  Wavefront sensing enabled us to evaluate the induced irregular astigmatism caused by tear film break-up quantitatively. Wavefront aberrations should be measured carefully to avoid the effects of tear film break-up, especially in wavefront-guided refractive surgery.
authors.affiliation: Department of Ophthalmology, Suita, Japan.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Koh
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Maeda
authors.forename: Teruhito
authors.initials: T
authors.lastname: Kuroda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hori
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujikado
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tano
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hirohara
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Mihashi
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000175:diagnosis*; D003315:Cornea / Q000378:metabolism*; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D012029:Refraction, Ocular; D013666:Tears / Q000378:metabolism*