title: Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues.
abstract: Co-expression of B-cell leukemia-lymphoma 2 gene (Bcl-2) and Epstein-Barr virus latent membrane protein 1 (LMP-1) in nasopharyngeal carcinoma tissues were tested using immunohistochemical methods. Results showed that there were 32% (14/44) and 68% (30/44) LMP-1 and Bcl-2-positive cases, respectively. Among the LMP-1-positive tissues, 8 (57%) of 14 specimens were also Bcl-2-positive. The level of LMP-1 and Bcl-2 expression was associated with the clinical stages of nasopharyngeal carcinoma. Furthermore, when LMP-1- and Bcl-2-positive cases were combined, the highest positive score was found in clinical stage II as well as in the early stage (stages I and II) of nasopharyngeal carcinoma. While further studies with more cases are needed, this study suggests that co-expression of Bcl-2 and LMP-1 may be involved in the process of nasopharyngeal carcinoma aggravation.
authors.affiliation: National Taichung Nursing College, School of Medical Technology, Taipei Medical University, Taiwan, ROC. johnlu@ntcnc.edu.tw
authors.forename: John Jenn-Yenn
authors.initials: JJ
authors.lastname: Lu
authors.forename: Chi-Long
authors.initials: CL
authors.lastname: Chen
authors.forename: Tsuey-Ying
authors.initials: TY
authors.lastname: Hsu
authors.forename: Jen-Yang
authors.initials: JY
authors.lastname: Chen
authors.forename: Ih-Jen
authors.initials: IJ
authors.lastname: Su
authors.forename: Winston C Y
authors.initials: WC
authors.lastname: Yu
authors.forename: Czau-Siung
authors.initials: CS
authors.lastname: Yang
mesh_terms: D001706:Biopsy; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D017403:In Situ Hybridization; D009092:Mucous Membrane / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D009367:Neoplasm Staging; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D014763:Viral Matrix Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019253:Proto-Oncogene Proteins c-bcl-2; D014763:Viral Matrix Proteins