Polymer-supported ferrocenyl oxazolines for the catalyzed highly enantioselective phenyl transfer to aldehydes.
A new chiral MeO-PEG-supported ferrocenyl oxazoline was synthesized and successfully employed in the enantioselective phenyl transfer to aldehydes. The products were obtained in high yields and with excellent enantioselectivities (up to 97% ee). Furthermore, the recovery of the ferrocene was facile, and catalyst efficiency was maintained in subsequent reactions.
Bolm
Carsten
C
Institut für Organische Chemie, RWTH Aachen, Prof.-Pirlet-Str. 1, Germany. carsten.bolm@oc.rwth-aachen.de
Hermanns
Nina
N
Classen
Arno
A
Muñiz
Kilian
K
D001547:Benzaldehydes / Q000737:chemistry*; D001559:Benzhydryl Compounds / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D000075163:Metallocenes; D010081:Oxazolone / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
D001547:Benzaldehydes; D001559:Benzhydryl Compounds; D005296:Ferrous Compounds; D000075163:Metallocenes; D011108:Polymers; C461065:trifluoromethyloxazolinone; D010081:Oxazolone; D015032:Zinc; C004998:ferrocene