Free fatty acid metabolism in human skeletal muscle is regulated by PPARgamma and RXR agonists.
Free fatty acid (FFA) oxidation in human skeletal muscle cells can be stimulated, both independently and in a synergistic manner, by agonists for PPARgamma and RXR. Increased FFA disposal in muscle through augmented oxidation could reduce intramyocellular lipid accumulation. The abilities of such agents to improve glucose tolerance and insulin action may thus involve effects on both glucose and FFA metabolism.
Ciaraldi
Theodore P
TP
Veterans Affairs San Diego Healthcare System, California 92161, USA.
Cha
Bong-Soo
BS
Park
Kyong-Soo
KS
Carter
Leslie
L
Mudaliar
Sunder R
SR
Henry
Robert R
RR
D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D010084:Oxidation-Reduction; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D018168:Receptors, Retinoic Acid / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*
D005230:Fatty Acids, Nonesterified; D018160:Receptors, Cytoplasmic and Nuclear; D018168:Receptors, Retinoic Acid; D014157:Transcription Factors