title: Antibacterial activity of calozeyloxanthone isolated from Calophyllum species against vancomycin-resistant Enterococci (VRE) and synergism with antibiotics.
abstract: Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synergism between 1 and vancomycin hydrochloride (VCM) against VRE was also observed. These findings suggest that 1 in combination with VCM against VRE may be useful in controlling VRE infections.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakagami
authors.forename: K
authors.initials: K
authors.lastname: Kajimura
authors.forename: W M N M
authors.initials: WM
authors.lastname: Wijesinghe
authors.forename: H R W
authors.initials: HR
authors.lastname: Dharmaratne
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D029759:Calophyllum; D004357:Drug Synergism; D016983:Enterococcus / Q000187:drug effects*; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology*; D044004:Xanthones
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C400966:calozeyloxanthone; D014640:Vancomycin