Inmunoferon, a glycoconjugate of natural origin, regulates the liver response to inflammation and inhibits TNF-alpha production by an HPA axis-dependent mechanism.
In this report, we have examined the mechanism of action of Inmunoferon, a patented glycoconjugate (GC) of natural origin with immunomodulatory properties, in the regulation of TNF-alpha expression induced by LPS challenge in a rodent model. GC was found to be dependent on a normal HPA response to exert its regulatory effect on TNF-alpha expression. Adrenalectomized mice were unresponsive to the drug in terms of TNF-alpha levels after LPS challenge, whereas control mice showed lower serum TNF-alpha levels when treated with GC than vehicle-treated animals. GC treatment also induced the expression of acute phase proteins but it did not alter the normal metabolism or viability of hepatic cells. These data suggested the employment of GC as a novel adjuvant during antibacterial treatment without disadvantages such as side effects in the metabolism of the liver, thus, acting as an enhancer of the host response against infection.
Brieva
A
A
R&D Department, Industrial Farmaceútica Cantabria SA, Madrid, Spain.
Guerrero
A
A
Pivel
J P
JP
D000818:Animals; D002130:Calcium Phosphates / Q000494:pharmacology*; D002478:Cells, Cultured; D006001:Glycoconjugates / Q000494:pharmacology*; D006020:Glycopeptides / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D002130:Calcium Phosphates; D006001:Glycoconjugates; D006020:Glycopeptides; D014409:Tumor Necrosis Factor-alpha; C038773:Immunoferon