The role of dendritic cells during Salmonella infection.
One type of phagocytic antigen-presenting cell (APC) - the dendritic cell (DC) - may have specialized functions during infection with the bacterium Salmonella, including a possible role in transporting Salmonella across the intestinal barrier. In addition, changes in the number, localization and cytokine production of CD8alpha+, CD8alpha-CD4+ and CD8alpha-CD4- DC subsets occur during infection. DCs function in stimulating bacteria-specific T cells by direct presentation of Salmonella antigens and as bystander APCs. Studying the function of DCs during Salmonella infection provides insight into the capacity of these sophisticated APCs, which are a key link between innate and adaptive immunity, to initiate and modulate the immune response to a bacterial infection.
Wick
Mary Jo
MJ
Department of Clinical Immunology, University of Göteborg, Guldhedsgatan 10, Göteborg, Sweden. mary-jo.wick@immuno.gu.se
D000818:Animals; D017951:Antigen Presentation; D015703:Antigens, CD / Q000032:analysis; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D051379:Mice; D012480:Salmonella Infections / Q000276:immunology*; D012486:Salmonella typhimurium
D015703:Antigens, CD; D016207:Cytokines