Transmission of drug-resistant HIV after an occupational exposure despite postexposure prophylaxis with a combination drug regimen.
We documented a case of occupational human immunodeficiency virus (HIV) despite postexposure prophylaxis (PEP) with a combination drug regimen after percutaneous injury with a needle from a sharps disposal container in the hospital room of an HIV-infected patient. This failure of PEP with a combination drug regimen may have been related to antiretroviral drug resistance, other factors, or both. This case highlights the importance of preventing injury to prevent occupational transmission of HIV.
Beltrami
Elise M
EM
Prevention and Evaluation Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Luo
Chi-Cheng
CC
de la Torre
Nicolas
N
Cardo
Denise M
DM
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission*; D006282:Health Personnel; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D019259:Lamivudine / Q000627:therapeutic use; D016602:Needlestick Injuries; D016273:Occupational Exposure; D017211:Treatment Failure; D015215:Zidovudine / Q000627:therapeutic use
D019380:Anti-HIV Agents; D019259:Lamivudine; D015215:Zidovudine