Poorly differentiated carcinomas of the thyroid gland: a review of the clinicopathologic features of a series of 28 cases of a heterogeneous, clinically aggressive group of thyroid tumors.
We evaluated the clinicopathologic, immunohistochemical, lectin histochemical, ultrastructural and morphometric characteristics of a series of 28 poorly differentiated carcinomas of the thyroid (PDCT). The 28 tumors were classified according to their predominant growth pattern as insular (n=12), trabecular (n=10) and solid subtypes (n=6). The overall mortality rate was 46%. No significant differences were found among the 3 subtypes. Data obtained by lectin histochemistry, electron microscopy, and morphometry point to a closer relationship of PDCT to follicular than to papillary carcinoma. Our results do not support the subdivision of PDCT into subtypes.
Sobrinho-Simões
Manuel
M
Institute of Molecular Pathology and Immunology of the University of Porto-IPATIMUP, Portugal.
Sambade
Clara
C
Fonseca
Elsa
E
Soares
Paula
P
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000737:chemistry / Q000145:classification / Q000401:mortality / Q000556:secondary*; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000145:classification / Q000401:mortality / Q000473:pathology*
D014408:Biomarkers, Tumor; D037102:Lectins