Pancreatic sepsis: prevention and therapy.
Except for a minority of early fatalities, most deaths in acute pancreatitis occur after the first 7 to 10 days due to infective complications, particularly infected necrosis. Hence, preventing this risk factor seems to represent a major step forward in the clinical management of severe pancreatitis. Consequently, antibiotics emerged as a cornerstone of the treatment of severe acute pancreatitis. The duration of such treatment, the route of administration and the substance(s) of choice need to be carefully selected. Surgical debridement is the treatment of choice of infected necrosis, while percutaneous drainage is successful in some patients.
Gloor
Beat
B
Department of Visceral and Transplantation Surgery, Inselspital, University of Bern, Switzerland.
Schmidtmann
Andreas B
AB
Worni
Mathias
M
Ahmed
Zulfiqar
Z
Uhl
Waldemar
W
Büchler
Markus W
MW
D006801:Humans; D010195:Pancreatitis / Q000517:prevention & control* / Q000628:therapy*; D018805:Sepsis / Q000517:prevention & control* / Q000628:therapy*