title: Distribution of intrachromosomal telomeric sequences (ITS) on Macaca fascicularis (Primates) chromosomes and their implication for chromosome evolution.
abstract: The intrachromosomal location of the telomeric sequence in the crab-eating macaque, Macaca fascicularis (F. Cercopithecidae, Catarrhini) has been analysed by fluorescent in situ hybridisation with a long synthetic (TTAGGG)(n) probe. A total of 237 metaphases was analysed. As expected, all telomeres hybridised with the probe and 90 intrachromosomal loci with different hybridisation frequencies were also detected. The chromosomal location of interstitial telomeric sequences in M. fascicularis and in Homo sapiens was then compared, 37 sites (41.11%) being found to be conserved. Some of these sequences can be derived from rearrangements, such as inversions (MFA13q23) or fusions (MFA2p13 and MFA13p12), that have taken place during karyotype evolution.
authors.affiliation: Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Ruiz-Herrera
authors.forename: F
authors.initials: F
authors.lastname: García
authors.forename: C
authors.initials: C
authors.lastname: Azzalin
authors.forename: E
authors.initials: E
authors.lastname: Giulotto
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
authors.forename: M
authors.initials: M
authors.lastname: Ponsà
authors.forename: M
authors.initials: M
authors.lastname: Garcia
mesh_terms: D000818:Animals; D001483:Base Sequence; D002873:Chromosome Fragility / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008252:Macaca fascicularis / Q000235:genetics*; D013045:Species Specificity; D020080:Tandem Repeat Sequences; D016615:Telomere / Q000235:genetics*