title: Physiologic effects of lowering caloric intake in nonhuman primates and nonobese humans.
abstract: Caloric restriction (CR) reduces the rate of aging and increases life span in all small animal species studied to date, but the effects of CR in humans remain uncertain. This review summarizes current knowledge of the effects of CR in nonhuman primates and humans. The results suggest that CR has a range of beneficial effects in nonhuman primates studied under laboratory conditions, and short-term markers of CR seen in animal models appear to occur in humans subject to CR also. However, the overall benefit of CR in human populations remains to be established, and studies in human populations are needed.
authors.affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA. sroberts@hnrc.tufts.edu
authors.forename: S B
authors.initials: SB
authors.lastname: Roberts
authors.forename: X
authors.initials: X
authors.lastname: Pi-Sunyer
authors.forename: L
authors.initials: L
authors.lastname: Kuller
authors.forename: M A
authors.initials: MA
authors.lastname: Lane
authors.forename: P
authors.initials: P
authors.lastname: Ellison
authors.forename: J C
authors.initials: JC
authors.lastname: Prior
authors.forename: S
authors.initials: S
authors.lastname: Shapses
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition; D001842:Bone and Bones / Q000502:physiology; D002149:Energy Intake; D004734:Energy Metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D011323:Primates / Q000502:physiology*; D012016:Reference Values; D012098:Reproduction
chemical_list: D008055:Lipids