title: Surgery for carcinoma of the gallbladder. Our experience.
abstract: BACKGROUND
  Carcinoma of the gallbladder is a gastrointestinal malignancy with a very poor prognosis. The 5-year survival rate amounts to less than 5% in most series. In this study we reviewed the results of surgical treatment for gallbladder carcinoma with special reference to extended radical procedures.
  
  
  METHODS
  Between 1995 and 2000 we enrolled 36 patients (17 males and 19 females), 24 of whom were treated with simple cholecystectomy and 12 with radical resection (partial hepatectomy, regional lymphadenectomy, and common bile duct resection). The tumours were classified by stage using the criteria of the American Joint Committee on Cancer (AJCC). Stages, operative procedures, results of pathologic examinations and the outcome of the resected cases were reviewed.
  
  
  RESULTS
  There were 2 postoperative deaths (0.55%). The mean follow-up period was 19.1 months (range 1-60). For stage I and II disease extended cholecystectomy had a better result than simple cholecystectomy: the 5-year survival rates were 38.4 versus 19%, respectively. For the patients with advanced stage III or IV gallbladder carcinoma, a significant advantage of survival resulted in case of liver resection as compared to surgical treatment without liver resection: the 5-year survival rates were 20 and 0%, respectively.
  
  
  CONCLUSIONS
  The survival of stage I-II patients was good. For the patients in higher stages the prognosis was significantly worse. In these cases more aggressive surgery may be needed.
authors.affiliation: Department of Gastroenterology, Ospedale S. Giovanni Battista, Turin, Italy. leone.nic@tiscalinet.it
authors.forename: N
authors.initials: N
authors.lastname: Leone
authors.forename: P
authors.initials: P
authors.lastname: De Paolis
authors.forename: M
authors.initials: M
authors.lastname: Garino
authors.forename: F
authors.initials: F
authors.lastname: Brunello
authors.forename: M
authors.initials: M
authors.lastname: Carrera
authors.forename: R
authors.initials: R
authors.lastname: Pellicano
authors.forename: G R
authors.initials: GR
authors.lastname: Fronda
authors.forename: C
authors.initials: C
authors.lastname: Bumma
authors.forename: M
authors.initials: M
authors.lastname: Rizzetto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002763:Cholecystectomy; D005260:Female; D005706:Gallbladder Neoplasms / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies