title: 17Beta-estradiol stimulates regeneration of sciatic nerve in female mice.
abstract: In ovariectomized mice with and without estrogen replacement, regeneration of the sciatic nerve after crush injury was studied. Functional recovery, quantified with sciatic functional index was significantly accelerated in estrogen-treated mice throughout the regeneration. On semi-thin sections of sciatic nerves in estrogen-treated mice we registered a greater total number of regenerating nerve fibers at the first week, and a higher mean axonal area at the third week of regeneration. Our results demonstrated that estrogen treatment enhances regeneration of the sciatic nerve.
authors.affiliation: Department of Physiology, The Brody School of Medicine, East Carolina University, 600 Moye Blvd., Greenville, NC 27858, USA.
authors.forename: Rustem R
authors.initials: RR
authors.lastname: Islamov
authors.forename: Wesley A
authors.initials: WA
authors.lastname: Hendricks
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Jones
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Lyall
authors.forename: Nicole S
authors.initials: NS
authors.lastname: Spanier
authors.forename: Alexander K
authors.initials: AK
authors.lastname: Murashov
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002452:Cell Count; D003714:Denervation; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009414:Nerve Growth Factors / Q000097:blood / Q000494:pharmacology; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology*; D018696:Neuroprotective Agents / Q000097:blood / Q000494:pharmacology*; D020127:Recovery of Function / Q000187:drug effects* / Q000502:physiology; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D020426:Sciatic Neuropathy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D012737:Sex Factors
chemical_list: D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D004958:Estradiol