title: Lactic acidosis and abnormal liver function in advanced HIV disease.
abstract: A 48 year old man receiving HAART presented with late stage HIV disease, non-specific symptoms, a normal sized liver, ascites, and lactic acidosis. Following a failed liver biopsy worsening acidosis developed, requiring ICU support. Progressive liver failure occurred. Endoscopy showed oesophageal varices and a transjugular liver biopsy showed non-cirrhotic cholestasis; findings that were ascribed to HAART.
authors.affiliation: Department of Genito-Urinary Medicine, Mortimer Market Centre, Camden and Islington Community Health Services NHS Trust, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Shahmanesh
authors.forename: J
authors.initials: J
authors.lastname: Cartledge
authors.forename: R
authors.initials: R
authors.lastname: Miller
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged