title: Randomized controlled trial of a treatment for anorexia and bulimia nervosa.
abstract: Evidence for the effectiveness of existing treatments of patients with eating disorders is weak. Here we describe and evaluate a method of treatment in a randomized controlled trial. Sixteen patients, randomly selected out of a group composed of 19 patients with anorexia nervosa and 13 with bulimia nervosa, were trained to eat and recognize satiety by using computer support. They rested in a warm room after eating, and their physical activity was restricted. The patients in the control group (n = 16) received no treatment. Remission was defined by normal body weight (anorexia), cessation of binge eating and purging (bulimia), a normal psychiatric profile, normal laboratory test values, normal eating behavior, and resumption of social activities. Fourteen patients went into remission after a median of 14.4 months (range 4.9-26.5) of treatment, but only one patient went into remission while waiting for treatment (P = 0.0057). Relapse is considered a major problem in patients who have been treated to remission. We therefore report results on a total of 168 patients who have entered our treatment program. The estimated rate of remission was 75%, and estimated time to remission was 14.7 months (quartile range 9.6 > or = 32). Six patients (7%) of 83 who were treated to remission relapsed, but the others (93%) have remained in remission for 12 months (quartile range 6-36). Because the risk of relapse is maximal in the first year after remission, we suggest that most patients treated with this method recover.
authors.affiliation: Section of Applied Neuroendocrinology and Center for Eating Disorders, Karolinska Institutet, Novum, S-141 57 Huddinge, Sweden. cecelia.bergh@neurotec.ki.se
authors.forename: Cecilia
authors.initials: C
authors.lastname: Bergh
authors.forename: Ulf
authors.initials: U
authors.lastname: Brodin
authors.forename: Greger
authors.initials: G
authors.lastname: Lindberg
authors.forename: Per
authors.initials: P
authors.lastname: Södersten
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000523:psychology / Q000628:therapy*; D001521:Behavior Therapy; D015992:Body Mass Index; D002032:Bulimia / Q000523:psychology / Q000628:therapy*; D002648:Child; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012527:Satiation; D013813:Therapy, Computer-Assisted; D016896:Treatment Outcome