title: [Diffuse hair loss in women].
abstract: The complaint "Doctor, I am losing my hair" represents a particular challenge to the physician, and involves making a specific diagnosis, selecting an appropriate therapy, and expressing empathy for the patient's anxiety. Diffuse hair loss in women was formerly classified as an entity of its own. Since the identification of female pattern hair loss, most cases have been recognized to be due to androgenetic alopecia, often during phases of life characterized by fluctuations of sexual hormone levels or in connection with intake or cessation of hormonal therapy. The most difficult differential diagnosis includes androgenetic alopecia, chronic telogen effluvium, and psychogenic pseudo efflvuium. Androgenetic alopecia is due to androgen-induced, non-synchronized, progressive shortening of the hair growth cycle and gradually leads to thinning of the central scalp area. Idiopathic chronic telogen effluvium typically occurs in women, starting abruptly without a recognizable initiating factor, and involves the entire scalp area with increased shedding of telogen hair. It is believed to be due to synchronization phenomena of the cyclic hair growth. Psychogenic pseudo effluvium affects fashion-oriented, self-conscious women suffering of a discrepancy between the actual state of their hair and idealized expectations. Later the problem of age-related hair thinning oft becomes a surrogate for the more generalized problem of senescence. Rational therapy of androgenetic alopecia aims at blocking the androgen effect on hair follicles with estrogens and antiandrogens or at pharmacologically reversing vellus hair transformation with topical minoxidil. In contrast, women with idiopathic chronic telogen effluvium should be reassured that their problem is rather a state of exaggerated "hair shedding" than of actual "hair loss".
authors.affiliation: Dermatologische Klinik, UniversitätsSpital Zürich.
authors.forename: R M
authors.initials: RM
authors.lastname: Trüeb
mesh_terms: D000328:Adult; D000368:Aged; D000505:Alopecia / Q000188:drug therapy / Q000209:etiology*; D000726:Androgen Antagonists / Q000627:therapeutic use; D003937:Diagnosis, Differential; D045166:Estradiol Congeners / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D008914:Minoxidil / Q000627:therapeutic use
chemical_list: D000726:Androgen Antagonists; D045166:Estradiol Congeners; D008914:Minoxidil