Lack of association between estrogen receptor 1 gene polymorphisms and multiple sclerosis in southern Italy in humans.
Estrogen receptor 1 gene polymorphisms (ESR1) have been found to be associated with multiple sclerosis (MS) in both Japanese and Finnish populations. We investigated the association between ESR1 polymorphisms (PvuII and XbaI) and MS in a study of 132 MS patients and 129 controls from the same geographic background (southern Italy). Allelic and genotypic frequencies were not different between MS patients and population controls for either the PvuII or XbaI polymorphism. This result suggests that the association between a given disease and a genomic characteristic must be confirmed by separate investigations in different populations.
Savettieri
Giovanni
G
Institute of Neurology, University of Palermo, Palermo, Italy.
Cittadella
Rita
R
Valentino
Paola
P
Manna
Ida
I
Andreoli
Virginia
V
La Russa
Antonella
A
La Porta
Gaetana
G
Ruscica
Francesca
F
Ragonese
Paolo
P
Pirritano
Domenico
D
Bonavita
Simona
S
Tedeschi
Gioacchino
G
Quattrone
Aldo
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D047628:Estrogen Receptor alpha; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*
D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen