title: A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission.
abstract: We performed a clinical comparison of unrelated cord blood transplantation (UCBT) and unrelated bone marrow transplantation in adult acute leukaemia patients in complete remission (CR) who received the same conditioning regimen, graft-versus-host disease (GvHD) prophylaxis and supportive treatment. The incidence of acute GvHD was almost the same between the two groups, but the haematopoietic recovery was delayed and the incidence of chronic GvHD was higher in the UCBT group. The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT.
authors.affiliation: Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. jun-ooi@ims.u-tokyo.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Ooi
authors.forename: Tohru
authors.initials: T
authors.lastname: Iseki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Tomonari
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nagayama
authors.forename: Koji
authors.initials: K
authors.lastname: Ishii
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sato
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shindo
authors.forename: Rieko
authors.initials: R
authors.lastname: Sekine
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ohno
authors.forename: Kaoru
authors.initials: K
authors.lastname: Uchimaru
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Nagamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Shirafuji
authors.forename: Arinobu
authors.initials: A
authors.lastname: Tojo
authors.forename: Kenzaburo
authors.initials: K
authors.lastname: Tani
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Asano
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D018572:Disease-Free Survival; D005260:Female; D005312:Fetal Blood; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012074:Remission Induction