Understanding the pathogenesis of ANCA: where are we today?
The role of ANCA, ANCA antigens, endothelial cell damage, genetic and environmental pressures, and the "activatability" of leukocytes will probably prove to be important variables in human ANCA vasculitis. The advent of a reliable animal model may open new areas of investigation and treatment of these vasculitic conditions.
Preston
Gloria A
GA
Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA.
Yang
Jia Jin
JJ
Xiao
Hong
H
Falk
Ronald J
RJ
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology / Q000378:metabolism*; D001324:Autoantigens / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D053146:Myeloblastin; D018375:Neutrophil Activation / Q000276:immunology; D009195:Peroxidase / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism; D015398:Signal Transduction; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001324:Autoantigens; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin