title: Callyspongynic acid, a polyacetylenic acid which inhibits alpha-glucosidase, from the marine sponge Callyspongia truncata.
abstract: A new polyacetylenic acid, callyspongynic acid (1), was isolated as an alpha-glucosidase inhibitor from the marine sponge Callyspongia truncata. Its structure was determined by spectroscopic and chemical methods.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Taisuke
authors.initials: T
authors.lastname: Uehara
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matunaga
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D002855:Chromatography, Thin Layer; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009426:Netherlands; D019906:Nuclear Magnetic Resonance, Biomolecular; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D004791:Enzyme Inhibitors; D004952:Esters; D011108:Polymers; C464988:callyspongynic acid; C464987:methylcallyspongynate; D005959:Glucosidases; D000114:Acetylene