Suppressed cytotoxic T lymphocyte responses in experimental cysticercosis.
Mitogen-induced T cell responses are suppressed in mice infected with larvae of Taenia crassiceps. The effects of experimental infection on specific T cell responses, however, have not been examined. In the present study, we demonstrate that larval-infected mice exhibit suppressed ability to develop anti-virus specific cytotoxic T lymphocyte (CTL) responses while maintaining apparently normal natural killer (NK) cell responsiveness.
Spolski
R J
RJ
Laboratory of Molecular Immunology, NHLBI/NIH, Bethesda, MD 20892, USA.
Alexander-Miller
M A
MA
Kuhn
R E
RE
D000818:Animals; D002860:Chromium Radioisotopes / Q000276:immunology; D003551:Cysticercosis / Q000276:immunology*; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013621:Taenia / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology
D002860:Chromium Radioisotopes