A new diterpene from Tanaecium jaroba.
One new diterpene, 2 alpha-hydroxy-12beta-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COSY, HMQC, HMBC, ROESY) and their antiplasmodial activities were evaluated in vitro against Plasmodium falciparum.
Mitaine-Offer
Anne-Claire
AC
Sauvain
Michel
M
Deharo
Eric
E
Muñoz
Victoria
V
Zèches-Hanrot
Monique
M
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D029402:Bignoniaceae; D001838:Bolivia; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
C465104:2-hydroxy-12-hydroxy-isopimara-8(14), 15-diene; D000962:Antimalarials; D004224:Diterpenes; D010936:Plant Extracts