title: One source for distortion product otoacoustic emissions generated by low- and high-level primaries.
abstract: Distortion product otoacoustic emissions (DPOAE) elicited by tones below 60-70 dB sound pressure level (SPL) are significantly more sensitive to cochlear insults. The vulnerable, low-level DPOAE have been associated with the postulated active cochlear process, whereas the relatively robust high-level DPOAE component has been attributed to the passive, nonlinear macromechanical properties of the cochlea. However, it is proposed that the differences in the vulnerability of DPOAEs to high and low SPLs is a natural consequence of the way the cochlea responds to high and low SPLs. An active process boosts the basilar membrane (BM) vibrations, which are attenuated when the active process is impaired. However, at high SPLs the contribution of the active process to BM vibration is small compared with the dominating passive mechanical properties of the BM. Consequently, reduction of active cochlear amplification will have greatest effect on BM vibrations and DPOAEs at low SPLs. To distinguish between the "two sources" and the "single source" hypotheses we analyzed the level dependence of the notch and corresponding phase discontinuity in plots of DPOAE magnitude and phase as functions of the level of the primaries. In experiments where furosemide was used to reduce cochlear amplification, an upward shift of the notch supports the conclusion that both the low- and high-level DPOAEs are generated by a single source, namely a nonlinear amplifier with saturating I/O characteristic.
authors.affiliation: School of Biological Sciences, University of Sussex, Brighton, United Kingdom. a.lukashkin@sussex.ac.uk
authors.forename: Andrei N
authors.initials: AN
authors.lastname: Lukashkin
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Lukashkina
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Russell
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D001489:Basilar Membrane / Q000187:drug effects / Q000502:physiology*; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D005665:Furosemide / Q000494:pharmacology; D006168:Guinea Pigs; D008144:Loudness Perception / Q000187:drug effects / Q000502:physiology*; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects / Q000502:physiology*; D010897:Pitch Discrimination / Q000187:drug effects / Q000502:physiology*; D013018:Sound Spectrography
chemical_list: D005665:Furosemide