title: [Genetic susceptibility to cancer].
abstract: Hereditary predisposition is a common trait of many cancers. 15 to 20 percent of all cancers occur in individuals who have inherited a single gene alteration being members of families where multiple persons carry a high risk of developing cancer. Other than these so-called high penetrance genes which confer elevated risks of cancer development, there are many other genes that generate less dramatic but clinically important risks of cancer, often only if associated to specific exposures.
authors.affiliation: Facultatea de Medicină Disciplina de Genetică Umană, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: O
authors.initials: O
authors.lastname: Stoica
authors.forename: I
authors.initials: I
authors.lastname: Sandovici
authors.forename: M
authors.initials: M
authors.lastname: Covic
mesh_terms: D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*