[Relationship between the effect of carbamazepine on SCE frequencies and folic acid in epileptic patients].
Peripheral blood lymphocyte sister chromatid exchange(SCE) frequencies, serum folic acid(FA) levels were examined in 15 epileptic patients treated with carbamazepine(CBZ), and another 15 epileptic patients treated with CBZ and folic acid(FA). The untreated epileptic patients and the healthy subjects served as control. The results showed that SCE frequencies were significantly higher in CBZ Group, compared with CBZ plus FA Group and control(P < 0.01). Serum FA levels were lower in CBZ Group compared with healthy control(P < 0.01). It suggests that CBZ can induce the increase of SCE frequencies. Supplementation with FA may effectively prevent chromosome DNA damage induced by CBZ.
Li
S
S
Department of Neurology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Lü
B
B
Yang
X
X
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D002648:Child; D017029:Epilepsy, Complex Partial / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012854:Sister Chromatid Exchange
D000927:Anticonvulsants; D002220:Carbamazepine; D005492:Folic Acid