Sex differences in photoperiod control of antigen-specific primary and secondary humoral immunity in Siberian Hamsters.
Photoperiod was hypothesized to mediate T cell-dependent B cell production of IgM and IgG. Antigens induced production of specific immunoglobulins; serum IgM but not IgG, was higher in males in long vs. short days (16 vs. 8 h light/day) and similarly among all groups of females. A second immunization with KLH robustly enhanced serum IgM, as well as IgG; increases were blunted in short- vs. long-day males but not in females. Thus, in male but not female hamsters, winter-like short days restrain aspects of primary and secondary humoral immune responses to xenoantigens. Actions on lymphocyte activities or clonal expansion are in considerations.
Hadley
Allison R
AR
Center for Perinatal Biology, Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Tran
Long T
LT
Fagoaga
Omar R
OR
Nehlsen-Cannarella
Sandra L
SL
Yellon
Steven M
SM
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology*; D000941:Antigens / Q000276:immunology / Q000494:pharmacology; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects / Q000276:immunology*; D006224:Cricetinae; D005260:Female; D006433:Hemocyanins / Q000276:immunology / Q000494:pharmacology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000187:drug effects / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000276:immunology*; D017111:Phodopus; D017440:Photoperiod; D012621:Seasons; D012727:Sex Characteristics
D000941:Antigens; D002352:Carrier Proteins; C105104:Cavin3 protein, rat; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D047908:Intracellular Signaling Peptides and Proteins; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin