Epimerization study on [18f]FDG produced by an alkaline hydrolysis on solid support under stringent conditions.
Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and finally hydrolyzed within the cartridge, at room temperature, using sodium hydroxide. The present study demonstrated that no epimerization of [18F]FDG to [18F]FDM occurs even when 12 N NaOH is used and when the hydrolysis time is extended up to 1 h. The alkaline hydrolysis on solid support appears to be a simple method leading to [18F]FDG with high purity.
Mosdzianowsk
C
C
Coincidence Technologies s.a., Parc Scientifique du Sart Tilman, Liège, Belgium. mos@coincidence.com
Lemaire
C
C
Simoens
F
F
Aerts
J
J
Morelle
J L
JL
Luxen
A
A
D019788:Fluorodeoxyglucose F18 / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007536:Isomerism; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012972:Sodium Hydroxide
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D012972:Sodium Hydroxide