[Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice].
Female transgenic FVB mice transfected with the mammary erbB-2/neu oncogene were injected 0.1 ml 0.9% solution of sodium chloride (control), 1 meg Vilon peptide (Lys-Glu) or Epitalon peptide (Ala-Glu-Asp-Glu), s.c., 5 days in succession once a month, beginning from the age of 2 months. The characteristics of mammary tumor induction in the control and experimental groups did not differ until the age of 9 months. Later on, Epitalon-treated mice revealed distinct inhibition of carcinogenesis. One tumor per animal was detected in 7% (control), 4% (Vilon) and 16% (Epitalon) (p < 0.05). Two or more tumors per animal were in 75%, 95% and 56%, respectively (p < 0.05). Largest diameter of mammary adenocarcinoma in the Epitalon group was smaller than in controls by 33% (p < 0.05). Although the number of mice with metastases to the lung in all three groups was practically identical, their incidence in the Vilon group was 2.6 times higher than in Epitalon-treated animals (p < 0.05). Largest diameter of metastasis in the Epitalon group was the smallest, too. Our data point to inhibition of mammary carcinogenesis by Epitalon in transgenic erbB-2/neu mice.
Alimova
I N
IN
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Bashurin
D A
DA
Popovich
I G
IG
Zabezhinskiĭ
M A
MA
Volkov
M A
MA
Provinciali
M
M
Franceschi
C
C
Khavincon
B Kh
BKh
Anisimov
V N
VN
D000230:Adenocarcinoma / Q000235:genetics / Q000517:prevention & control*; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D004151:Dipeptides / Q000627:therapeutic use*; D005260:Female; D018734:Genes, erbB-2; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000517:prevention & control*; D051379:Mice; D008822:Mice, Transgenic; D009842:Oligopeptides / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D009842:Oligopeptides; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine