title: Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling.
abstract: Secreted proteins of the Hedgehog (Hh) family direct the development of diverse organs and tissues of vertebrates and invertebrates. Gli-type zinc finger proteins function as transcriptional mediators of the Hh signaling cascade and were implicated both in the activation and repression of Hh target genes. The differential activity of Gli-type zinc finger proteins is regulated on the level of proteolytic processing and subcellular localization as a complex concert of Hh-responsive, intracellular determinants. Here, we provide a survey of recent studies on the characterization of molecular mechanisms involved in the interpretation of Hh signals by Gli-type zinc finger proteins.
authors.affiliation: Georg-August-Universität Göttingen, Institute of Biochemistry and Molecular Cell Biology, Humboldtallee 23, 37073 Göttingen, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Koebernick
authors.forename: Tomas
authors.initials: T
authors.lastname: Pieler
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D053823:Hedgehog Proteins; D006801:Humans; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000071676:Zinc Finger Protein GLI1; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D015513:Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1; C092937:ci protein, Drosophila; C077245:hh protein, Drosophila