Hematopoietic cellular therapy: implications for the flow cytometry laboratory.
Advances in hematopoietic stem cell transplantation, gene therapy, and immunotherapy have necessitated a host of novel monitoring procedures. Cell sorting is also coming of age as a clinical procedure designed to organize hematopoietic grafts for specificity of cellular components designed for individual patients or diseases. This article has focused on these novel developments in their historical context. The next generation of transplantation flow cytometry promises to be an exciting one.
Lamb
Lawrence S
LS
Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of South Carolina School of Medicine, South Carolina Cancer Center, 14 Medical Park, Suite 500, Columbia, SC 29203, USA. larry.lamb@palmettohealth.org
D000818:Animals; D018952:Antigens, CD34 / Q000032:analysis; D002452:Cell Count; D002469:Cell Separation / Q000379:methods; D005434:Flow Cytometry / Q000379:methods*; D005456:Fluorescent Dyes; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D006086:Graft vs Host Disease / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D020544:Graft vs Leukemia Effect; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016130:Immunophenotyping; D008212:Lymphocyte Depletion / Q000379:methods; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000145:classification / Q000276:immunology; D018183:Transplantation Chimera / Q000097:blood
D018952:Antigens, CD34; D005456:Fluorescent Dyes