title: Prospective comparative study of spiral computer tomography and magnetic resonance imaging for detection of hepatocellular carcinoma.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is often detected at a relatively late stage when tumour size prohibits curative surgery. Screening to detect HCC at an early stage is performed for patients at risk.
  
  
  OBJECTIVE
  The aim of this study was to compare prospectively the diagnostic accuracy and classification for management of the two state of the art secondline imaging techniques: triphasic spiral computer tomography (CT) and super paramagnetic iron oxide (SPIO) enhanced magnetic resonance imaging (MRI).
  
  
  METHODS
  Sixty one patients were evaluated between January 1996 and January 1998. Patients underwent CT and MRI within a mean interval of 6.75 days.
  
  
  METHODS
  CT and MRI were evaluated blindly for the presence and number of lesions, characterisation of these lesions, and classification for management. For comparison of the data on characterisation, the CT and MRI findings were compared with histopathological studies of the surgical specimens and/or follow up imaging. Data of patients not lost to follow up were available to January 2001.
  
  
  RESULTS
  SPIO enhanced MRI detected more lesions and overall smaller lesions than triphasic spiral CT (number of lesions 189 v 124; median diameter 1.0 v 1.8 cm; Spearman rank's correlation coefficient 0.63, p<0.001). There was no significant difference in accuracy between CT and MRI for lesion characterisation. The agreement in classification for management was very good (weighted kappa 0.91, 95% CI 0.83-0.99).
  
  
  CONCLUSIONS
  SPIO enhanced MRI detects more and smaller lesions, but both techniques are comparable in terms of classification for management. SPIO enhanced MRI may be preferred as there is no exposure to ionising radiation.
authors.affiliation: Department of Radiology, Erasmus Medical Centre Rotterdam, University of Amsterdam, The Netherlands. j.stoker@amc.uva.nl
authors.forename: J
authors.initials: J
authors.lastname: Stoker
authors.forename: M G
authors.initials: MG
authors.lastname: Romijn
authors.forename: R A
authors.initials: RA
authors.lastname: de Man
authors.forename: J T
authors.initials: JT
authors.lastname: Brouwer
authors.forename: G J
authors.initials: GJ
authors.lastname: Weverling
authors.forename: J M
authors.initials: JM
authors.lastname: van Muiswinkel
authors.forename: P E
authors.initials: PE
authors.lastname: Zondervan
authors.forename: J S
authors.initials: JS
authors.lastname: Laméris
authors.forename: J N M
authors.initials: JN
authors.lastname: Ijzermans
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000601:surgery; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography