title: Glycemic and insulinemic responses of nondiabetic healthy adult subjects to an experimental acid-induced viscosity complex incorporated into a glucose beverage.
abstract: OBJECTIVE
  An acid-induced-viscosity (I-V) complex containing alginate, citrate, and insoluble calcium was incorporated into a glucose-based beverage. We hypothesized that the acid I-V beverage would become viscous in the stomach (due to the solubilization of calcium and its interaction with alginate and citrate) and would blunt glycemia.
  
  
  METHODS
  Thirty subjects were used in a double-masked, placebo-controlled crossover study evaluating the acid I-V complex. The placebo was a glucose-based beverage that had a similar total dietary fiber level and initial viscosity (Control). After a 12-h overnight fast, serum glucose and insulin were monitored over a 3-h postprandial period.
  
  
  RESULTS
  The postprandial mean peak incremental change from baseline in serum glucose tended (P < 0.06) to be lower for the acid I-V product. The net incremental area under the curve (AUC) for serum glucose was reduced 75% (P < 0.01) by the acid I-V product, which was due mainly to an increased undershoot. The mean peak incremental change from baseline in serum insulin was higher (P < 0.05) for the acid I-V product. Net incremental AUC for serum insulin did not differ (P > 0.20) between products.
  
  
  CONCLUSIONS
  Results of this study suggested that the acid I-V complex may attenuate the postprandial glycemic response to a glucose challenge in healthy subjects.
authors.affiliation: Ross Products Division of Abbott Laboratories, 625 Cleveland Avenue, Columbus, OH 43215-1724, USA. bryan.wolf@rossnutrition.com
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Wolf
authors.forename: Chron-Si
authors.initials: CS
authors.lastname: Lai
authors.forename: Mark S
authors.initials: MS
authors.lastname: Kipnes
authors.forename: Deborah G
authors.initials: DG
authors.lastname: Ataya
authors.forename: Keith B
authors.initials: KB
authors.lastname: Wheeler
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Zinker
authors.forename: Keith A
authors.initials: KA
authors.lastname: Garleb
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Firkins
mesh_terms: D000328:Adult; D000464:Alginates / Q000008:administration & dosage; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism*; D002118:Calcium / Q000008:administration & dosage; D019343:Citric Acid / Q000008:administration & dosage; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000032:analysis; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000097:blood*; D007700:Kinetics; D008297:Male; D010919:Placebos; D014783:Viscosity
chemical_list: D000464:Alginates; D001786:Blood Glucose; D004043:Dietary Fiber; D006603:Hexuronic Acids; D007328:Insulin; D010919:Placebos; D019343:Citric Acid; D020723:Glucuronic Acid; D005947:Glucose; D002118:Calcium