The role of dendritic cells in neurodegenerative diseases.
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) involved in the induction of adaptive immune responses. The presence of DCs in the central nervous system (CNS) and the active participation of the immune system in a variety of neurodegenerative diseases have been demonstrated. This review will discuss recent findings pertinent to DCs and other antigen-presenting cells in the CNS in health and disease states.
Iribarren
Pablo
P
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31-40, Frederick, MD 21702, USA. iribarrenp@mail.ncifcrf.gov
Cui
You-Hong
YH
Le
Yingying
Y
Wang
Ji Ming
JM
D000544:Alzheimer Disease / Q000209:etiology / Q000276:immunology; D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology; D001921:Brain / Q000276:immunology; D003713:Dendritic Cells / Q000502:physiology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology; D006801:Humans; D017628:Microglia / Q000276:immunology; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000276:immunology*; D017096:Prion Diseases / Q000209:etiology / Q000276:immunology