[Coronary thrombosis on patient with the factor V Leiden mutation].
We report a documented observation of coronary thrombosis occurring in a 25-year-old patient with no risk factor, presenting a hereditary thrombophilia (facteur V Leiden) diagnosed a few months earlier in a context of venous thrombosis. This patient had a spread out anterior myocardial infarction with cardiac arrest due to a ventricular fibrillation; although he was quickly rescued by the mobile intensive Care Unit, the patient died 48 hours later, after cerebral anoxia. The mutation called factor V Leiden is a widely spread hereditary family thrombophilia (5 to 6% of the population) and is characterized by a resistance to activated C protein provoking a hypercoagulable state. The unexpected arterial thrombosis, very rare in that case, can be extremely serious and raises the question of a preventive medication such as antiplatelet agent or low-molecular-weight heparin as soon as the genetic abnormally has been proved to be symptomatic.
Corre
O
O
Département d'anesthésie-réanimation chirurgicale, CHU Cavale Blanche, 29609 Brest, France.
Gueret
G
G
Gilard
M
M
Abgrall
J F
JF
Arvieux
C C
CC
D000328:Adult; D003328:Coronary Thrombosis / Q000097:blood / Q000209:etiology*; D005165:Factor V / Q000235:genetics*; D017809:Fatal Outcome; D006801:Humans; D002534:Hypoxia, Brain / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics; D009203:Myocardial Infarction / Q000150:complications; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics*
D005165:Factor V