title: Local antiseptic therapy for non-gonococcal urethritis: phase II study with Instillagel.
abstract: Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeutic outcome, a smear was taken from the urethra and an urine examination was performed at baseline as well as at 5 and 8 days after the start of the treatment. Pain and micturition symptoms were determined by a questionnaire with analog scales taken before and after therapy. A pre/post comparison of the urethral smears of the patients with symptomatic NGU showed a significant difference (P < 0.0001). The microbial count in the urine did not show a significant difference. The symptoms micturition (P<0.0001) and pain in the urethra (P<0.0001) were significantly improved. This Phase II study confirmed that local antiseptic treatment of NGU can offer an alternative to systemic antibiotic treatment.
authors.affiliation: Urologische Klinik der Universität Essen, Germany. herbert.sperling@uni-essen.de
authors.forename: H
authors.initials: H
authors.lastname: Sperling
authors.forename: H P
authors.initials: HP
authors.lastname: Bastian
authors.forename: F
authors.initials: F
authors.lastname: Boeminghau
authors.forename: G
authors.initials: G
authors.lastname: Ludwig
authors.forename: B
authors.initials: B
authors.lastname: Terhorst
authors.forename: H
authors.initials: H
authors.lastname: Rübben
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004338:Drug Combinations; D006069:Gonorrhea; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D010146:Pain / Q000503:physiopathology; D016896:Treatment Outcome; D014521:Urethra / Q000382:microbiology; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D014554:Urination
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; C008129:chlorhexidine gluconate, lidocaine drug combination; D008012:Lidocaine; D002710:Chlorhexidine