Manufacturing and characterization of 3-d hydroxyapatite bone tissue engineering scaffolds.
Internal architecture has a direct impact on the mechanical and biological behaviors of porous hydroxyapatite (HA) implants. However, traditional processing methods provide very minimal control in this regard. This paper reviews a novel processing technique developed in our laboratory for fabricating scaffolds with controlled internal architectures. The preliminary mechanical property and in vivo evaluation of these scaffolds are also presented.
Chu
T-M G
TM
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. ctmin@engin.umich.edu
Hollister
S J
SJ
Halloran
J W
JW
Feinberg
S E
SE
Orton
D G
DG
D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000378:metabolism* / Q000502:physiology*; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D012984:Software; D013552:Swine; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D017886:Durapatite