Subtypes A, C, G, and recombinant HIV type 1 are circulating in Bangladesh.
We analyzed the genetic diversity of HIV-1 circulating in Bangladesh by direct sequencing and subsequent phylogenetic analysis of the V3 region of the env gene and p17 fragment of the gag gene from nine unrelated patients. The sequences from one sample grouped into subtype A, five samples grouped into subtype C, and one grouped into subtype G. In addition, two patients appeared to be infected with different recombinant viruses consisting of subtype A and unclassifiable viral sequences. Epidemiological analysis revealed heterosexual transmission in the majority of cases. Furthermore, most subjects had a history of traveling, either to India or to the Arabian Peninsula. This study shows that several HIV-1 subtypes are circulating in Bangladesh, and we conclude that there must have been several introductions of HIV-1 into the Bangladeshi population.
Ljungberg
Karl
K
Swedish Institute for Infectious Disease Control, and Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 82 Solna, Sweden.
Hassan
Mohammed Sawkat
MS
Islam
Mohammad Nazrul
MN
Siddiqui
Mahbub Alam
MA
Aziz
Mohammad Monowar
MM
Wahren
Britta
B
Islam
Khalid Bin
KB
Leitner
Thomas
T
D000328:Adult; D001459:Bangladesh / Q000453:epidemiology; D005260:Female; D015683:Gene Products, gag / Q000235:genetics; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000235:genetics; D010802:Phylogeny; D017423:Sequence Analysis, RNA
D015683:Gene Products, gag; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments