Integrins and prostate cancer metastases.
Integrins have emerged as modulators of a variety of cellular functions. They have been implicated in cell migration, survival, normal and aberrant cellular growth, differentiation, gene expression, and modulation of intracellular signal transduction pathways. In this review article, the structural and functional characteristics of integrins, their expression and their potential role in prostate cancer metastases will be discussed.
Fornaro
M
M
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
Manes
T
T
Languino
L R
LR
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008297:Male; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology
D016023:Integrins; D009363:Neoplasm Proteins