title: Somatic glypican 3 (GPC3) mutations in Wilms' tumour.
abstract: Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development.
authors.affiliation: Cancer Research UK Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.
authors.forename: G R M
authors.initials: GR
authors.lastname: White
authors.forename: A M
authors.initials: AM
authors.lastname: Kelsey
authors.forename: J M
authors.initials: JM
authors.lastname: Varley
authors.forename: J M
authors.initials: JM
authors.lastname: Birch
mesh_terms: D017931:DNA Primers / Q000737:chemistry; D053673:Glypicans; D019812:Heparan Sulfate Proteoglycans / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D009396:Wilms Tumor / Q000235:genetics*
chemical_list: D017931:DNA Primers; D053673:Glypicans; D019812:Heparan Sulfate Proteoglycans