Study of the effects of microgravity on cell growth of human antibody producing cells and their secretions.
Several attempts have been made to investigate the effects of microgravity on the growth and function of animal cells. Cellular activation of immune T lymphocytes is greatly affected by microgravity. On the other hand, little is known about the effects of microgravity on B lymphocytes, another major class of immune lymphocytes, their growth or antibody production. Our approach to investigate the human B lymphocytes was to compare cell growth, nutrient consumption, and antibody secretion by a human B cell hybridoma between the cells cultured in space and the ground culture.
Suganuma
T
T
Laboratory of Biological Science, Mitsui Pharmaceuticals, Inc.
O'oka
H
H
Fukuda
T
T
D000641:Ammonia / Q000378:metabolism; D000917:Antibody Formation / Q000502:physiology*; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D002455:Cell Division; D002460:Cell Line; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D013026:Space Flight; D014893:Weightlessness
D007075:Immunoglobulin M; D005973:Glutamine; D000641:Ammonia