title: Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin.
abstract: Single- and Multi-step selection studies were used to test the ability of BMS-284756, ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin to yield resistant clones from 12 quinolone-susceptible and -resistant Streptococcus pneumoniae strains. Although all quinolones selected, to a greater or lesser degree, for resistant clones with mutations usually in parC or gyrA, BMS-284756 tended to select for resistant clones at a lower rate than other quinolones studied.
authors.affiliation: Department of Pathology, Hershey Medical Center, PO Box 850, 500 University Drive, Hershey, PA 17033, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Clark
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: T A
authors.initials: TA
authors.lastname: Davies
authors.forename: B
authors.initials: B
authors.lastname: Bozdogan
authors.forename: B
authors.initials: B
authors.lastname: Dewasse
authors.forename: M R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: P C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D001692:Biological Transport; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics; D024841:Fluoroquinolones; D006801:Humans; D007211:Indoles; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D011804:Quinolines; D015363:Quinolones; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D007211:Indoles; D009287:Naphthyridines; D011804:Quinolines; D015363:Quinolones; D002939:Ciprofloxacin; D064704:Levofloxacin; C080163:trovafloxacin; D015242:Ofloxacin; D000077266:Moxifloxacin; C419689:garenoxacin