Levels of lipid peroxidation products in a chronic inflammatory disorder.
We have examined the plasma levels of the lipid peroxidation products 4-hydroxy-nonenal and malondialdehyde in a carefully controlled study of age and sex-matched subjects with rheumatoid arthritis in whom potentially confounding influences such as disease modifying anti-rheumatic drugs (DMARDs), self-medication and vitamin supplements were eliminated. The plasma concentrations of the antioxidants uric acid and vitamin E were also measured. The results reveal a strong and consistent inverse correlation between the levels of lipid peroxidation products in the plasma and erythrocyte sedimentation rate (ESR). There is no indication that vitamin E or urate function as the major antioxidant agent in arthritis, as has been suggested in more seriously affected patients. It is concluded that there is no evidence that vitamin E is more important, and urate less important as an antioxidant in mild arthritis. The correlation between lipid peroxidation and ESR suggests a more complex relationship than has been assumed.
Deaney
C L
CL
Institute of Biomedical & Life Sciences, University of Glasgow, UK.
Feyi
K
K
Forrest
C M
CM
Freeman
A
A
Harman
G
G
McDonald
M S
MS
Petrie
A
A
Shaw
S J
SJ
Stone
T W
TW
Stoy
N
N
Darlington
L G
LG
D000328:Adult; D000447:Aldehydes / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000447:Aldehydes; D014810:Vitamin E; D014527:Uric Acid; D008315:Malondialdehyde; C027576:4-hydroxy-2-nonenal