title: Pathogenesis and pathology of hematogenous infections of the fetus and newborn.
abstract: The earlier infections occur in intrauterine life the more severe are they. When the infection develops during embryogenesis, the lesions are much more serious, sometimes causing disruptions (malformations). At this time the organs are not completely formed and microorganisms may interfere with organogenesis to such an extent that the development of the functions necessary for viability become impaired. Infection acquired in utero may result in resorption of the embryo, abortion, stillbirth, neonatal death, intrauterine growth retardation (IUGR), or prematurity. The infected newborns commonly are apparently normal at birth but they may develop a late onset disease. Otherwise, neonates presenting symptomatology may derelop untoward sequelae.
authors.affiliation: Department of Pathology, Federal University of Bahia, Brazil. achilea@uol.com.br
authors.forename: Achiléa Lisboa
authors.initials: AL
authors.lastname: Bittencourt
authors.forename: Aparecida Gomes Pinto
authors.initials: AG
authors.lastname: Garcia
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology; D001424:Bacterial Infections / Q000151:congenital* / Q000473:pathology; D005260:Female; D005313:Fetal Death; D005315:Fetal Diseases / Q000209:etiology / Q000473:pathology; D005317:Fetal Growth Retardation; D005333:Fetus / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011528:Protozoan Infections / Q000151:congenital* / Q000473:pathology; D014777:Virus Diseases / Q000151:congenital* / Q000473:pathology