title: Structural and functional analyses of bacterial lipopolysaccharides.
abstract: Bacterial lipopolysaccharides (LPSs) are powerful immunomodulators in infected hosts, and may cause endotoxic shock. Most of them share a common architecture but vary considerably in structural motifs from one genus, species, and strain to another. Cells of the innate immune response recognize evolutionarily conserved LPS molecular patterns of endotoxins and structural details thereby greatly influencing their response.
authors.affiliation: Equipe Endotoxines, UMR 8619 du Centre National de la Recherche Scientifique, Biochimie, Université de Paris-Sud, Orsay, France. martine.caroff@bbmpc.u-psud.fr
authors.forename: Martine
authors.initials: M
authors.lastname: Caroff
authors.forename: Doris
authors.initials: D
authors.lastname: Karibian
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Cavaillon
authors.forename: Nicole
authors.initials: N
authors.lastname: Haeffner-Cavaillon
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008070:Lipopolysaccharides / Q000737:chemistry* / Q000276:immunology*; D015394:Molecular Structure; D009000:Monocytes / Q000276:immunology; D012772:Shock, Septic / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides