[Significance of changes in individual indicators on intravascular homeostasis in development of circulatory hypoxia in aging].
The study comprised 45 healthy subjects aged 60-74. It was designed to examine the state of skin and bulbar microcirculation using the method of television capillaroscopy. The functional state of endothelial microvessels was studied with the help of laser doppler flowmeter by means of functional tests with postocclusion hyperaemia and intradermal injection of epinephrine solution in the dose of 0.1 ml (1.10-6 mol/l). The platelets aggregation activity was studied using the method of turbidimetry. The blood viscosity and functional state of erythrocytes were determined with the help of rotary viscosimeter at the shift velocity of 10 to 200s-1 with estimating the erythrocytes deformability and aggregation indexes. Oxygen saturation of the subcutaneous fat fibers was studied by polarography. It has been found that the increase of adrenalin-induction aggregation of platelets, the decrease of erythrocyte deformation and the endothelium synthesis disturbance caused relaxing factors play role in the circulatory hypoxia development.
Korkushko
O V
OV
Institute of Gerontology AMS of Ukraine, 04114, Kiev.
Lishnevskaia
V Iu
VIu
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001809:Blood Viscosity; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology*; D004912:Erythrocytes / Q000166:cytology; D006706:Homeostasis; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008833:Microcirculation; D008875:Middle Aged; D010974:Platelet Aggregation; D012016:Reference Values