Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats.
We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.
Baba
Seigo
S
Nutritional Science Center, Health Laboratory, Meiji Seika Kaisha, Ltd., Sakado-shi, Saitama, Japan. seigo_baba@meiji.co.jp
Osakabe
Naomi
N
Natsume
Midori
M
Terao
Junji
J
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics*; D044946:Biflavonoids; D001682:Biological Availability; D002392:Catechin / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D019327:Copper Sulfate / Q000494:pharmacology; D007408:Intestinal Absorption; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D044945:Proanthocyanidins; D051381:Rats; D017207:Rats, Sprague-Dawley
D000975:Antioxidants; D044946:Biflavonoids; D008054:Lipid Peroxides; D044945:Proanthocyanidins; C479580:procyanidin B2; C017674:procyanidin; D002392:Catechin; D019327:Copper Sulfate