Delta-opioid receptor antagonists as a new concept for central acting antitussive drugs.
Our recent findings indicated that mu- and kappa-opioid receptors enhance each other's antitussive processes. However, delta-opioid receptors played an inhibitory role in antitussive processes mediated by the mu- and kappa-opioid receptors. We also concluded that delta(1)-opioid receptors may play an inhibitory role, whereas delta(2)-opioid receptors may play a synergistic role, in antitussive processes mediated by mu-opioid receptors. Furthermore, we clearly demonstrated that delta-opioid receptor antagonists, such as naltrindole and 7-benzylidenenaltrexone, produced potent antitussive effects. These delta-opioid receptor-mediated antitussive effects may be mediated by the antagonism of delta(1)-, but not delta(2)-opioid receptors. In this review, we study the possibility of the delta-opioid receptor antagonist as a new concept for central acting antitussive drugs.
Kamei
Junzo
J
Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142-8501, Japan. kamei@hoshi.ac.jp
D000996:Antitussive Agents / Q000627:therapeutic use*; D003371:Cough / Q000188:drug therapy*; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors*
D000996:Antitussive Agents; D017465:Receptors, Opioid, delta