title: Life-threatening hyperkalemia: a complication of spironolactone for heart failure in a patient with renal insufficiency.
abstract: Serum potassium concentration should be measured immediately before operation to detect hyperkalemia in heart failure patients treated with spironolactone. Renal insufficiency, advanced age, potassium supplementation, decompensated congestive heart failure, and a spironolactone dose larger than 25 mg/d increase the risk of hyperkalemia as a consequence of spironolactone therapy.
authors.affiliation: Department of Anesthesiology, Division of Cardiothoracic and Vascular Anesthesia, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Hu
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Carpenter
authors.forename: Albert T
authors.initials: AT
authors.lastname: Cheung
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D001784:Blood Gas Analysis; D006333:Heart Failure / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006947:Hyperkalemia / Q000097:blood / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000097:blood / Q000209:etiology; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications*; D013148:Spironolactone / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D011188:Potassium