Nationwide survey of in vitro activities of itraconazole and voriconazole against clinical Aspergillus fumigatus isolates cultured between 1945 and 1998.
The isolates in a collection of 170 Aspergillus fumigatus isolates recovered from 114 patients and 21 different medical centers in The Netherlands over a period of 53 years were tested for the presence of resistance to itraconazole and voriconazole according to the guidelines of NCCLS document M38-P and by the E-test. Three isolates were highly resistant to itraconazole, and voriconazole MICs were low for all isolates.
Verweij
Paul E
PE
Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands. p.verweij@mmb.azn.nl
Te Dorsthorst
Debbie T A
DT
Rijs
Anthonius J M M
AJ
De Vries-Hospers
Hilly G
HG
Meis
Jacques F G M
JF
D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000302:isolation & purification; D025141:Drug Resistance, Fungal; D006801:Humans; D066298:In Vitro Techniques; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009426:Netherlands; D011743:Pyrimidines / Q000494:pharmacology*; D013997:Time Factors; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D065819:Voriconazole