[Adrenal cortex response to prolonged administration of low doses of magnesium chlorate in rats].
Rat adrenals were studied using histological and histochemical methods during prolonged intoxication with pesticide magnesium chlorate which was administered in a dose equal to 1/100 of LD50 (41 mg/kg of body weight). Animals that received distilled water and were kept in similar conditions were used as control. It was demonstrated that intoxication of rats for 3-7 days results in increased secretory activity of all the zones of adrenal cortex. Later (after 14-90 days) the zonal response to pesticide administration was variable. Magnesium chlorate treatment results in the disturbances of hormonal synthesis in adrenocorticocytes. Compensatory-adaptive capacities of zona fasciculata were found to be greater than those in zona glomerulosa and zona reticularis.
Blinova
S A
SA
Department of Histology, Samarkand Medical Institute, Uzbekistan.
Ten
S A
SA
Islamov
Sh E
ShE
D000284:Administration, Oral; D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002704:Chlorates / Q000008:administration & dosage / Q000633:toxicity*; D006003:Glycogen / Q000378:metabolism; D007150:Immunohistochemistry; D007928:Lethal Dose 50; D050356:Lipid Metabolism; D017616:Magnesium Compounds / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D012313:RNA / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D015383:Zona Fasciculata / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015385:Zona Reticularis / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D002704:Chlorates; D017616:Magnesium Compounds; D012313:RNA; D006003:Glycogen; C033775:magnesium chlorate