Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats.
The response to opioids is reduced in neuropathic pain states. We examined the effect of the combination of morphine (0.1 mg/kg) and magnesium sulfate (125 mg/kg) on behavioral signs of neuropathic pain in spinal nerve ligated rats. Administered alone, neither drug produced any effect, but the combination exerted a significant anti-allodynic effect, which was partially reversed by naloxone. These results suggest that combining low doses of magnesium sulfate with opiates might be an alternative in treating neuropathic pain, with reduced risk of side effects.
Ulugol
Ahmet
A
Department of Pharmacology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey. aulugol@trakya.edu.tr
Aslantas
Aysegul
A
Ipci
Yesim
Y
Tuncer
Alev
A
Hakan Karadag
Cetin
C
Dokmeci
Ismet
I
D000818:Animals; D003080:Cold Temperature; D004359:Drug Therapy, Combination; D005260:Female; D007274:Injections, Intraperitoneal; D008026:Ligation; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D020422:Mononeuropathies / Q000188:drug therapy* / Q000503:physiopathology; D009020:Morphine / Q000008:administration & dosage*; D010146:Pain / Q000188:drug therapy*; D017288:Pain Threshold / Q000187:drug effects; D010812:Physical Stimulation; D051381:Rats; D017208:Rats, Wistar; D013127:Spinal Nerves / Q000502:physiology
D008278:Magnesium Sulfate; D009020:Morphine