title: Two GTP-binding Proteins Control Calcium-dependent Exocytosis in Chromaffin Cells.
abstract: The effect of guanosine triphosphate analogues on catecholamine secretion from permeabilized bovine chromaffin cells was examined. Guanosine 5'-[gamma-thio]triphosphate was demonstrated to produce a dual effect on calcium-evoked secretion, enhancing the release through a mechanism involving protein kinase C and inhibiting secretion by a protein kinase C-independent pathway. We propose that two functionally distinct G-proteins control the stimulus - secretion coupling in chromaffin cells.
authors.affiliation: Unité INSERM U-338 Biologie de la Communication Cellulaire, 5, rue Blaise Pascal, 67084 Strasbourg Cédex, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Sontag
authors.forename: Dominique
authors.initials: D
authors.lastname: Aunis
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Bader