Inflammatory mechanisms in cervicogenic headache: an integrative view.
Cervicogenic headache is a relatively common and still controversial form of headache that originates from the neck structures. The pathophysiology probably results from various local pain-producing factors, such as intervertebral dysfunction, but the frequent coexistence of a history of head traumas still plays an important role. This report represents a series of pathophysiologic studies performed for patients with cervicogenic headache and the results achieved by a new pharmacologic treatment for the disease.
Martelletti
Paolo
P
Department of Internal Medicine, Headache Center, 2nd School of Medicine, University La Sapienza, Policlinico Sant'Andrea, Via di Grottarossa 1035-1039, 00189 Rome, Italy. paolo.martelletti@uniroma1.it
D002574:Cervical Vertebrae / Q000276:immunology / Q000293:injuries; D020773:Headache Disorders / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D007375:Interleukin-1 / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D018836:Inflammation Mediators; D007375:Interleukin-1; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide