[Thrombosis induced by homocysteine does not depend on platelet aggregation or heparin cofactor's antithrombin activity].
OBJECTIVE
To partly elucidate the relationship between homocysteine(Hcy) and thrombosis, we observed Hcy's effects on platelet aggregation and antithrombin activity of heparin cofactor in vitro.


METHODS
Platelet aggregation assay and chromogenic assay were used in this research.


RESULTS
Homocysteine had no effects on platelet aggregation induced by ADP and thrombin or heparin cofactor's antithrombin activity in vitro (P > 0.05).


CONCLUSIONS
There is no correlation between Hcy and the "ADP passway" of platelet aggregation. Thrombosis induced by Hcy does not depend on heparin cofactor's antithrombin activity either.
Zhang
L
L
Haematological Research Department, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Zhang
G
G
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects; D005260:Female; D006493:Heparin / Q000494:pharmacology; D015844:Heparin Cofactor II / Q000378:metabolism*; D006710:Homocysteine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D013927:Thrombosis / Q000209:etiology*
D006710:Homocysteine; D015844:Heparin Cofactor II; D000990:Antithrombin III; D006493:Heparin