Keratitis, ichthyosis and deafness syndrome with development of multiple hair follicle tumours.
We report multiple occurrences of various kinds of tumours that originate from hair follicles in a patient diagnosed with KID (keratitis, ichthyosis, deafness) syndrome. These tumours are diagnosed as: (i) trichilemmal cysts in early lesions; (ii) proliferating trichilemmal tumours in moderate duration lesions; and (iii) malignant proliferating trichilemmal tumours in advanced lesions that are thought to progress from benign trichilemmal lesions. This three-step process raises the hypothesis of a multihit model that could account for the frequent development of tumours in KID patients.
Kim
K-H
KH
Department of Dermatology, School of Medicine, Chungnam National University, 640 Taesa-dong, Chung-gu, Taejon, 301-040 Korea.
Kim
J-S
JS
Piao
Y-J
YJ
Kim
Y-C
YC
Shur
K-B
KB
Lee
J-H
JH
Park
J-K
JK
D000328:Adult; D003638:Deafness; D005260:Female; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D007057:Ichthyosis / Q000473:pathology*; D007634:Keratitis / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013577:Syndrome