A possible association between high normal and high dose olanzapine and prolongation of the PR interval.
Two cases of light-headedness or 'fainting' in patients with schizophrenia treated with olanzapine are presented. Electrocardiogram investigation revealed first-degree heart block on high normal and high dose olanzapine, which normalized after dose reduction.
Kosky
Nick
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D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines; D004562:Electrocardiography / Q000187:drug effects; D006327:Heart Block / Q000139:chemically induced* / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine