[Morphological prognostic elements in gallbladder cancer].
BACKGROUND
The exact survival rates and prognostic factors of gallbladder cancer are still incompletely known.


OBJECTIVE
To report the actuarial survival of patients with gallbladder cancer.


METHODS
Six hundred thirty seven women, aged 59 years old as a mean and 108 men, aged 64 years old as a mean, with gallbladder cancer are reported. Patients were followed for up to 150 months.


RESULTS
Two hundred twenty four patients had an early and 521 had an advanced carcinoma. Overall survival was 38% at ten years. Sex or ethnic origin did not influence survival. Early tumors had a 92% survival at 10 years whereas the survival of advanced tumors was 16% at 5 years. Subserous tumors had a 5 years survival of 32% whereas serous tumors had a 5 years survival of 11%. Well-differentiated advanced tumors had a significantly better survival than moderately or poorly differentiated tumors. Vascular or lymphatic infiltration was also associated to a lower survival. All patients with advanced tumors and vascular infiltration died before 5 years.


CONCLUSIONS
Tumor infiltration and differentiation degree were the most important prognostic independent factors in gallbladder cancer.
Roa
Iván
I
Departamento de Anatomía Patológica y Cirugía Facultad de Medicina, Unidad de Epidemiología Clínica, Universidad de la Frontera, Chile. iroa@ufro.cl
de Aretxabala
Xabier
X
Araya
Juan C
JC
Villaseca
Miguel
M
Roa
Juan
J
Gilda
Ibacache T
IT
Burgos
Luis
L
Muñoz
Sergio
S
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology*; D017677:Age Distribution; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis