Airway nitric oxide in Duchenne muscular dystrophy.
The expression of muscle membrane-associated neuronal nitric oxide synthase (NOS1) is significantly impaired in Duchenne muscular dystrophy. Mean (+/- SEM) exhaled NO in 13 male patients with Duchenne muscular dystrophy was significantly lower than in 11 healthy age-matched male control subjects (7.5 +/- 1.4 vs 16.6 +/- 3.2 parts per billion, P <.02) or 17 adult male control subjects (18.5 +/- 1.8 parts per billion, P <.001). These findings provide indirect evidence that NOS1 contributes significantly to fractional exhaled nitric oxide in healthy children.
Straub
Volker
V
Children's Hospital, University of Essen, Germany.
Ratjen
Felix
F
Amthor
Helge
H
Voit
Thomas
T
Grasemann
Hartmut
H
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020388:Muscular Dystrophy, Duchenne / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I; D012129:Respiratory Function Tests
D009419:Nerve Tissue Proteins; D009569:Nitric Oxide; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I