Accelerated and improved osteointegration of implants biocoated with bone morphogenetic protein 2 (BMP-2).
A concept and methodology are presented for the direct biocoating of implantable metals like titanium and stainless steel with bone morphogenetic protein 2 (BMP-2) for future applications as cementless bone or dental prostheses. Such bioactive surfaces can influence cells and tissues by chemotactic as well as juxtacrine mechanisms. Reference is made to first experiments in sheep and rabbits in which BMP-2 coatings impressively increased the osteoinductive potential of titanium implants.
Jennissen
Herbert P
HP
Institute of Physiological Chemistry, University of Essen, Hufelandstrasse 55, D-45122 Essen, Germany. hp.jennissen@uni-essen.de
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001842:Bone and Bones / Q000166:cytology; D006801:Humans; D011994:Recombinant Proteins / Q000494:pharmacology; D012756:Sheep; D023822:Tissue Engineering / Q000379:methods*; D014025:Titanium / Q000494:pharmacology; D016212:Transforming Growth Factor beta
C525718:BMP2 protein, human; D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D014025:Titanium