HLA-DRB1*15 and pediatric aplastic anemia.
We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.
Oguz
Fatma S
FS
Yalman
Nevin
N
Diler
Ali Sarper
AS
Oguz
Rusdu
R
Anak
Sema
S
Dorak
Mehmet Tevfik
MT
D000741:Anemia, Aplastic / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002648:Child; D006684:HLA-DR Antigens / Q000097:blood*; D059811:HLA-DRB1 Chains; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D014421:Turkey
D015415:Biomarkers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D007166:Immunosuppressive Agents