Interactions between dead cells and dendritic cells in the induction of antiviral CTL responses.
Dendritic cells - professional antigen-presenting cells - are key players for activating adaptive immune responses against viruses. Apoptosis or lytic cell death often accompanies viral infection. Dendritic cells can acquire infected dead or dying cells as exogenous sources of antigens for presentation on MHC class I and II molecules to initiate T cell responses. This pathway of activating T cells may be critical for the development of effective antiviral immunity in vivo.
Fonteneau
Jean François
JF
Laboratory of Molecular Neuro-Oncology, The Rockefeller University New York, New York, NY 10021, USA.
Larsson
Marie
M
Bhardwaj
Nina
N
D017951:Antigen Presentation; D000956:Antigens, Viral / Q000276:immunology; D016923:Cell Death; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D011971:Receptors, Immunologic / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D000956:Antigens, Viral; D011971:Receptors, Immunologic