title: [A case of large-cell lung cancer successfully treated with docetaxel in combination with carboplatin and radiotherapy].
abstract: A 64-year-old male was referred to our hospital in September, 2000 for further examination of an abnormal chest shadow discovered in a regular health check-up. Chest X-P and CT revealed a large tumor in the left upper lobe, in association with hilar lymphadenopathy and costal invasion. Serum CEA was increased, and lung biopsy revealed a large-cell carcinoma. We performed chemoradiotherapy before surgery. Radiation (total 48 Gy) and 3 courses of chemotherapy with docetaxel (60 mg/m2) in combination with carboplatin (AUC = 6,600 mg) resulted in a remarkable reduction in the size of the mass, to less than 50%, and normalized serum CEA. Left upper lobectomy, lymphadenectomy and costectomy were performed. However, no tumor cells were detectable in the ablative specimen pathologically. These findings suggest the efficacy of chemoradiotherapy including docetaxel with carboplatin in patients with large-cell lung cancer.
authors.affiliation: First Dept. of Medicine, Shimane Medical University.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamane
authors.forename: Mitihiro
authors.initials: M
authors.lastname: Tumori
authors.forename: Masateru
authors.initials: M
authors.lastname: Nishiki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamauti
authors.forename: Manabu
authors.initials: M
authors.lastname: Yoshida
authors.forename: Riruke
authors.initials: R
authors.lastname: Maruyama
authors.forename: Nobue
authors.initials: N
authors.lastname: Uchida
authors.forename: Hajime
authors.initials: H
authors.lastname: Kitagaki
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kato
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018287:Carcinoma, Large Cell / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D000077143:Docetaxel; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011013:Pneumonectomy; D043823:Taxoids
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017239:Paclitaxel