Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection.
Recent studies suggest that immunologic containment of HIV-1 is possible and the immune correlates of this control are being defined. There have been significant advances in our ability to elicit virus-specific immune responses, which have led to viral control in animal models. Although viral escape from the immune system is an important challenge, new strategies for therapeutic and preventative HIV-1 vaccination are being vigorously pursued in human trials.
Gandhi
Rajesh T
RT
Partners AIDS Research Center and Infectious Diseases Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02114, USA. rgandhi@partners.org
Walker
Bruce D
BD
D016915:AIDS Vaccines / Q000627:therapeutic use; D000818:Animals; D002908:Chronic Disease; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy*; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity; D000882:Haplorhini; D006801:Humans; D007109:Immunity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014766:Viremia / Q000517:prevention & control
D016915:AIDS Vaccines