title: Solution-phase parallel synthesis of substituted benzimidazoles.
abstract: A solution-phase parallel synthesis of o-phenylenediamines is described. These intermediates were then subsequently converted to benzimidazole scaffolds (three-point diversity) in excellent purities and yields. High-throughput purification of this multistep synthetic sequence was accomplished using polymer-bound scavengers and reagents and liquid-liquid extraction protocols.
authors.affiliation: Department of Chemistry & Biophysics, Texas Biotechnology Corporation, 7000 Fannin, Suite 1920, Houston Texas 77030, USA.
authors.forename: B
authors.initials: B
authors.lastname: Raju
authors.forename: Noel
authors.initials: N
authors.lastname: Nguyen
authors.forename: George W
authors.initials: GW
authors.lastname: Holland