title: Transmission of drug-resistant HIV after an occupational exposure despite postexposure prophylaxis with a combination drug regimen.
abstract: We documented a case of occupational human immunodeficiency virus (HIV) despite postexposure prophylaxis (PEP) with a combination drug regimen after percutaneous injury with a needle from a sharps disposal container in the hospital room of an HIV-infected patient. This failure of PEP with a combination drug regimen may have been related to antiretroviral drug resistance, other factors, or both. This case highlights the importance of preventing injury to prevent occupational transmission of HIV.
authors.affiliation: Prevention and Evaluation Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: Elise M
authors.initials: EM
authors.lastname: Beltrami
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Luo
authors.forename: Nicolas
authors.initials: N
authors.lastname: de la Torre
authors.forename: Denise M
authors.initials: DM
authors.lastname: Cardo
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission*; D006282:Health Personnel; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D019259:Lamivudine / Q000627:therapeutic use; D016602:Needlestick Injuries; D016273:Occupational Exposure; D017211:Treatment Failure; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D019259:Lamivudine; D015215:Zidovudine