The phosphatidylinositol 3-Kinase AKT pathway in human cancer.
Vivanco
Igor
I
Department of Medicine and Molecular Biology Institute, UCLA School of Medicine, 11-935 Factor Building, 10833 LeConte Avenue, Los Angeles, California 90095, USA.
Sawyers
Charles L
CL
D000818:Animals; D002455:Cell Division; D004195:Disease Models, Animal; D017353:Gene Deletion; D006801:Humans; D008055:Lipids; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology*; D010641:Phenotype; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism / Q000502:physiology*; D018129:Phosphatidylinositol Phosphates / Q000502:physiology; D014176:Protein Biosynthesis; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D015398:Signal Transduction
D008055:Lipids; D019869:Phosphatidylinositol 3-Kinases; D018129:Phosphatidylinositol Phosphates; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; C060974:phosphatidylinositol 3,4,5-triphosphate; C494918:AKT1 protein, human