title: Understanding the pathogenesis of ANCA: where are we today?
abstract: The role of ANCA, ANCA antigens, endothelial cell damage, genetic and environmental pressures, and the "activatability" of leukocytes will probably prove to be important variables in human ANCA vasculitis. The advent of a reliable animal model may open new areas of investigation and treatment of these vasculitic conditions.
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA.
authors.forename: Gloria A
authors.initials: GA
authors.lastname: Preston
authors.forename: Jia Jin
authors.initials: JJ
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Falk
mesh_terms: D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology / Q000378:metabolism*; D001324:Autoantigens / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D053146:Myeloblastin; D018375:Neutrophil Activation / Q000276:immunology; D009195:Peroxidase / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism; D015398:Signal Transduction; D014657:Vasculitis / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001324:Autoantigens; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin