Ferulagone: a new monoterpene ester from Ferulago thirkeana essential oil.
Essential oil obtained by micro-distillation and hydrodistillation of the endemic Ferulago thirkeana (Boiss.) Boiss. (Apiaceae) was analysed by GC/MS. An unknown component isolated from the essential oil was characterized by chromato-spectral techniques (1D-, 2D-NMR, HRMS, IR and UV) as (1 S)-2,6,6-trimethyl-4-oxobicyclo[3.1.1]hept-2-enyl(2 E)-2-methylbut-2-enoate (= ferulagone or 1-angeloyloxyverbenone) (1). Biological activities of the essential oil and the purified major component (1) were tested against various human pathogenic microorganisms resulting in moderate inhibition (62.5 - 125 microg/ml).
Başer
K Hüsnü Can
KH
Demirci
Betül
B
Demirci
Fatih
F
Hashimoto
Toshihoro
T
Asakawa
Yoshinori
Y
Noma
Yoshiaki
Y
D019661:Apiaceae; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D009822:Oils, Volatile; D010936:Plant Extracts; D013729:Terpenes; C465103:ferulagone