title: The absorption and excretion of fluoride and arsenic in humans.
abstract: The absorption and excretion of fluoride and arsenic were measured in a group of healthy volunteers given drinking water with naturally high concentration of fluoride (F 2.3 mg/l)(,) or high concentration of arsenic (As 0.15 mg/l), or high concentrations of both fluoride and arsenic (F 2.25 mg/l, As 0.23 mg/l and F 4.05 mg/l, As 0.58 mg/l), respectively. The results indicated that, for arsenic, the absorption rate, the proportion of urinary excretion and the biological-half-life did not show statistically significant differences between drinking water containing high arsenic alone and drinking water containing different levels of high arsenic and fluoride. Excretion and retention of arsenic were positively correlated to the total arsenic intake. Similar results were observed for fluoride. This suggests that there are different metabolic processes for arsenic and fluoride in respect to absorption and excretion; and no joint action can be attributed by these two elements.
authors.affiliation: College of Public Health, Xinjiang Medical University, Urumqi 830054, People's Republic of China. zhyujian@xj.cninfo.net
authors.forename: Yujian
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jiyao
authors.initials: J
authors.lastname: Wu
authors.forename: Jack C
authors.initials: JC
authors.lastname: Ng
authors.forename: Guoquan
authors.initials: G
authors.lastname: Wang
authors.forename: Wu
authors.initials: W
authors.lastname: Lian
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001151:Arsenic / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D014874:Water Pollutants, Chemical; D001151:Arsenic; D005459:Fluorides