Improved Survival Rates in Mice that Received Prophylactic Fluids After Carcinogen Treatment.
During the development of a model for 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary adenocarcinoma in mice, a high mortality rate was attributed to dehydration. Therefore, we compared the acute survival of mice given subcutaneous fluids prophylactically immediately following DMBA gavage to that of animals provided treatment only when clinical signs of dehydration were observed. Mortality in the prophylactically treated mice was 5% compared to 47% in animals treated only after the manifestation of dehydration. Prophylaxis with subcutaneous fluids significantly reduces mortality in DMBA-treated mice.
Smith
Donald E.
DE
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Blumberg
Jeffrey B.
JB
Lipman
Ruth D.
RD