title: [Simultaneous presence of antibodies against the glomerular basement membrane and anti-myeloperoxidase antibodies in 2 patients with rapidly progressive glomerulonephritis].
abstract: We report two patients with rapidly progressive glomerulonephritis without alveolar hemorrhage. Renal biopsy showed extracapillary glomerulonephritis with linear deposits of immunoglobulin G. Serologically anti-glomerular basement membrane antibodies (Ac AMBG) and ANCA anti-myeloperoxidase were present. All patients were treated with steroids, cyclophosphamide and plasma exchange. One patient needed dialysis, and other one died from a renal biopsy complication. We discuss the epidemiologic, pathogenic and prognostic aspects of this association.
authors.affiliation: Servicio de Nefrología, Departamento de Anatomía Patológica, Hospital Universitario La Paz Madrid. cdiazr@hulp.insalud.es
authors.forename: C
authors.initials: C
authors.lastname: Díaz Rodríguez
authors.forename: O
authors.initials: O
authors.lastname: Costero
authors.forename: A
authors.initials: A
authors.lastname: Torre
authors.forename: F
authors.initials: F
authors.lastname: De Alvaro
authors.forename: F
authors.initials: F
authors.lastname: Gil
authors.forename: M L
authors.initials: ML
authors.lastname: Picazo
authors.forename: J
authors.initials: J
authors.lastname: Martínez-Ara
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology; D001706:Biopsy / Q000009:adverse effects; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007105:Immune Complex Diseases / Q000276:immunology / Q000473:pathology; D007074:Immunoglobulin G / Q000032:analysis; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology*; D010956:Plasmapheresis; D011379:Prognosis; D006435:Renal Dialysis; D012187:Retroperitoneal Space
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D009195:Peroxidase; D008775:Methylprednisolone