Effects of Roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes.
BACKGROUND
The macrolide antibiotic roxithromycin is effective against acne associated with inflammation, but the mechanism by which this is achieved has not been clarified.


OBJECTIVE
We studied the effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes in vitro.


RESULTS
Roxithromycin significantly inhibited the production of lipase and neutrophil chemotactic factor by P. acnes at a concentration one eighth of the MIC, at which the growth curve of P. acnes is not affected.


CONCLUSIONS
One mechanism of the effectiveness of roxithromycin in acne therapy is thought to be the inhibition of bacterial lipase and neutrophil chemotactic factor production by P. acnes.
Akamatsu
H
H
Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan. akamatsu@fujita-hu.ac.jp
Tomita
T
T
Horio
T
T
D000152:Acne Vulgaris / Q000378:metabolism* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000378:metabolism*; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D008049:Lipase / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000145:classification / Q000187:drug effects* / Q000378:metabolism; D015575:Roxithromycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D016209:Interleukin-8; D015575:Roxithromycin; D008049:Lipase