title: Relationship of wheezing to airflow obstruction in asthmatic children and a history of cough-variant asthma.
abstract: The aim of this study was to examine the relationship of wheezing to airflow obstruction during acute episodes of asthma in patients who had CVA (Cough variant asthma). Two groups of asthmatic children, one group with a past history of CVA (n = 13) and the other group without such a history (n = 14), were followed longitudinally for 12 months. During that time, they were evaluated for the presence of wheezing and the severity of airflow obstruction during acute episodes of asthma. Significant airflow obstruction occurred free of wheezing more frequently and the presence of clinical wheezing was associated with more severe airflow limitation, in asthmatic patients with a past history of CVA than in those without such a history. We conclude that asthmatic patients who have experienced CVA develop the wheezing symptom at a higher level of airflow obstruction.
authors.affiliation: Department of Pediatrics and Clinical Research Institute, Seoul National University Hospital, Korea. kohyy@plaza.snu.ac.kr
authors.forename: Young Yull
authors.initials: YY
authors.lastname: Koh
authors.forename: Yang
authors.initials: Y
authors.lastname: Park
authors.forename: Jin Hwa
authors.initials: JH
authors.lastname: Jeong
authors.forename: Chang Keun
authors.initials: CK
authors.lastname: Kim
authors.forename: Jin Tack
authors.initials: JT
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000150:complications* / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000379:methods; D016085:Bronchoconstrictor Agents; D002648:Child; D003371:Cough / Q000209:etiology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology*; D012135:Respiratory Sounds / Q000209:etiology*; D012720:Severity of Illness Index
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride