title: Biomaterials and scaffolds in reparative medicine.
abstract: Most approaches currently pursued or contemplated within the framework of reparative medicine, including cell-based therapies, artificial organs, and engineered living tissues, are dependent on our ability to synthesize or otherwise generate novel materials, fabricate or assemble materials into appropriate 2-D and 3-D forms, and precisely tailor material-related physical and biological properties so as to achieve a desired clinical response. This paper summarizes the scientific and technological opportunities within the fields of biomaterials science and molecular engineering that will likely establish new enabling technologies for cellular and molecular therapies directed at the repair, replacement, or reconstruction of diseased or damaged organs and tissues.
authors.affiliation: Department of Surgery, School of Medicine, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA. echaiko@emory.edu
authors.forename: Elliot L
authors.initials: EL
authors.lastname: Chaikof
authors.forename: Howard
authors.initials: H
authors.lastname: Matthew
authors.forename: Joachim
authors.initials: J
authors.lastname: Kohn
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
authors.forename: Glenn D
authors.initials: GD
authors.lastname: Prestwich
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Yip
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D036103:Nanotechnology; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials