Selected genetic factors associated with male infertility.
Studies into the mechanisms underlying spermatogenesis, the process by which spermatogonia undergo meiosis to become spermatozoa, have identified a number of genetic determinants of male infertility. Indeed, a more comprehensive knowledge of the genetic regulation of spermatogenesis has alleviated the dependence on the use of idiopathic infertility as a classification for sterile men for whom a cause for their infertility is unknown, as genetic factors become more accountable for this phenotype. This review focuses on selected areas implicated in male infertility including: (i) autosomal and sex chromosomal abnormalities; (ii) genetic disorders associated with impaired gonadotrophin secretion or action; (iii) microdeletions within regions of the Y-chromosome containing candidate gene families for spermatogenesis; (iv) the genetic nexus between cystic fibrosis and congenital bilateral absence of the vas deferens; and (v) insights into human infertility as gleaned from animal studies into mechanisms involving the Bcl-2 family of apoptosis regulators and the interaction between the c-kit encoded tyrosine kinase receptor and its ligand, stem cell factor. As significant advances continue to further knowledge of the genetic basis of male infertility, such as those leading to an understanding of the aforementioned areas, greater progress can be made to rectify or at least ameliorate social stigmas associated with sterility.
Huynh
Trieu
T
Monash Institute of Reproduction and Development, Centre for Early Human Development, Clayton, Victoria, Australia.
Mollard
Richard
R
Trounson
Alan
A
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002869:Chromosome Aberrations; D003550:Cystic Fibrosis / Q000235:genetics; D017353:Gene Deletion; D006062:Gonadotropins / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D012729:Sex Chromosome Aberrations; D013091:Spermatogenesis / Q000235:genetics; D014649:Vas Deferens / Q000002:abnormalities; D014998:Y Chromosome
D006062:Gonadotropins