title: Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles.
abstract: Chitosan (CS)-poly(acrylic acid) (PAA) complex nanoparticles, which are well dispersed and stable in aqueous solution, have been prepared by template polymerization of acrylic acid (AA) in chitosan solution. The physicochemical properties of nanoparticles were investigated by using size exclusion chromatography, FT-IR, dynamic light scattering, transmission electron microscope and zeta potential. It was found that the molecular weight of PAA in nanoparticles increased with the increase of molecular weight of CS, indicating that the polymerization of acrylic acid in the chitosan solution was a template polymerization. It was also found that the prepared nanoparticles carried a positive charge and showed the size in the range from 50 to 400 nm. The surface structure and zeta potential of nanoparticles can be controlled by different preparation processes. The experiment of in vitro silk peptide (SP) release showed that these nanoparticles provided a continuous release of the entrapped SP for 10 days, and the release behavior was influenced by the pH value of the medium.
authors.affiliation: Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
authors.forename: Yin
authors.initials: Y
authors.lastname: Ding
authors.forename: Haixiong
authors.initials: H
authors.lastname: Ge
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Changzheng
authors.initials: C
authors.lastname: Yang
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D012831:Bombyx; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002686:Chitin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D048271:Chitosan; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D019476:Insect Proteins / Q000008:administration & dosage; D008422:Materials Testing; D008854:Microscopy, Electron; D008863:Microspheres; D036103:Nanotechnology; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D019476:Insect Proteins; C065246:chitosan-poly(acrylic acid); D002686:Chitin; D048271:Chitosan