Nuclear lipid metabolism and signaling.
Evidence has been accumulating that nuclear lipid metabolism is involved in the regulation of nuclear functions. Here I describe an autonomous nuclear lipid signaling that has been found to be associated with the metabolism of such lipids as phosphoinositides, choline phospholipids, and the acylation and deacylation cycle. Some lipid signals from the plasma membrane ultimately reach the nucleus and regulate the nuclear function. In this case, however, generated lipids and their metabolites may not directly act on the nuclear factors involved in nuclear function. The unique and direct effects of nuclear lipids and their metabolites on nuclear factors are also discussed.
Tamiya-Koizumi
Keiko
K
Laboratory of Cancer Cell Biology, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School and Faculty of Medicine, Nagoya 464-8550, Japan. kkoizumi@med.nagoya-u.ac.jp
D000215:Acylation; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D002794:Choline / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D050356:Lipid Metabolism; D009685:Nuclear Envelope / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D009687:Nuclear Proteins; D014157:Transcription Factors; D010770:Phosphotransferases; D006867:Hydrolases; D002794:Choline