Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.
In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
Lees
N P
NP
Cancer Research UK, Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.
Harrison
K L
KL
Hill
E
E
Hall
C N
CN
Margison
G P
GP
Povey
A C
AC
D000230:Adenocarcinoma / Q000201:enzymology*; D000368:Aged; D000369:Aged, 80 and over; D000477:Alkylating Agents / Q000009:adverse effects / Q000493:pharmacokinetics; D002430:Cecal Neoplasms / Q000201:enzymology; D003106:Colon / Q000201:enzymology*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000032:analysis*; D012004:Rectal Neoplasms / Q000201:enzymology*; D012007:Rectum / Q000201:enzymology*; D012811:Sigmoid Neoplasms / Q000201:enzymology
D000477:Alkylating Agents; D009363:Neoplasm Proteins; D019853:O(6)-Methylguanine-DNA Methyltransferase