title: [Genomic organization of Norwalk-like viruses and functions of viral gene products].
abstract: Norwalk-like viruses(NLVs) that is one genus of the family Caliciviridae are major causative agents of nonbacterial acute gastroenteritis in human. NLVs have not yet been propagated in cell cultures and model animals, which restricts the fundamental studies. However, cDNA from several NLVs can be expressed in the cell-free system, bacterial cells, insect cells and mammalian cells. Studies on polyprotein processing by virus-encoded protease, enzymatic properties of RNA helicase, protease and RNA polymerase, capsid assembly, interaction between viral proteins or genomes and cellular proteins, the molecular mechanism of translation and transcription, and the crystal structure of the capsid protein and other viral proteins are in progress. Results will be useful for development of drugs for diarrheal therapy.
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Someya
mesh_terms: D000086042:3C Viral Proteases; D000595:Amino Acid Sequence; D003546:Cysteine Endopeptidases; D016679:Genome, Viral; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D016366:Open Reading Frames; D020815:Polyproteins / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry; D020365:RNA Helicases; D012324:RNA-Dependent RNA Polymerase; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D020815:Polyproteins; D011506:Proteins; D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase; D003546:Cysteine Endopeptidases; D000086042:3C Viral Proteases; D020365:RNA Helicases