Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin.
We assessed 77 twin pregnancies, comprising complete hydatidiform mole (CHM) and healthy co-twin, to ascertain the risks to the mother and baby of continuing the pregnancy, versus termination. 24 women with histologically confirmed CHM and healthy co-twin pregnancies decided to have a termination. 53 women continued with their pregnancies, though two had to have terminations because of severe pre-eclampsia, and 23 spontaneously aborted (<24 weeks' gestation). 28 pregnancies lasted 24 weeks or more, resulting in 20 livebirths. Chemotherapy to eliminate persistent gestational trophoblastic disease (pGTD) was required in three of 19 women (16%; 95% CI 3-39) who terminated their pregnancies in the first trimester, and in 12 of 58 (21%; 95% CI 11-33%) who continued their pregnancies. CHM and healthy co-twin pregnancies have a high risk of spontaneous abortion, but about 40% result in livebirths, without significantly increasing the risk of pGTD.
Sebire
Neil J
NJ
Trophoblastic Disease Unit, Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London W6 8RF, UK.
Foskett
Marianne
M
Paradinas
Fernando J
FJ
Fisher
Rosemary A
RA
Francis
Ros J
RJ
Short
Delia
D
Newlands
Edward S
ES
Seckl
Michael J
MJ
D000022:Abortion, Spontaneous / Q000209:etiology*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications*; D007231:Infant, Newborn; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000503:physiopathology*; D011256:Pregnancy Outcome; D012307:Risk Factors; D014427:Twins; D014594:Uterine Neoplasms / Q000150:complications*