[Diagnostic and prognostic reliability of interleukin-10 measurements in very low birth weight infants with late-onset sepsis].
BACKGROUND
There exists little data on releasing Interleukin-10 (IL-10) and on the clinical usefulness of its measurements in very low birth weight (VLBW) infants.


OBJECTIVE
The evaluation of diagnostic and prognostic reliability of IL-10 measurement in VLBW infants with sepsis.


METHODS
87 newborns with the median birth weight (BW) 1060 g and median gestational age (GA) 28 wks were divided into 3 groups: A) with no clinical signs of sepsis in the first month of life-control group (n = 28), B) with clinical signs of sepsis but with negative blood cultures (n = 13), and C) with clinically and microbiologically confirmed sepsis (n = 46). In the control group IL-10 was measured on admission and in the 10th, 20th and 30th day of life. The remaining newborns had IL-10 measured when sepsis was suspected.


RESULTS
IL-10 levels did not correlate with GA (R = -0.01) or BW (R = -0.04). In the control group there was no correlation between IL-10 levels and the calendar age. IL-10 levels were statistically higher in the group C than in the remaining ones (Me: 0 vs 1.32 vs 99.8 pg/ml). IL-10 level > 20 pg/ml allowed to distinguish between the group B and C with 79% sensitivity and 82% specificity. The highest levels of IL-10 were detected in the newborns who died of sepsis (Me = 889 pg/ml). IL-10 level > 680 pg/ml predicted the death of a newborn with 80% sensitivity and 100% specificity.


CONCLUSIONS
IL-10 measurements possess a great diagnostic and prognostic reliability and allow the detection of newborns with poor outcome, thus the measurement of IL-10 may be useful in clinical practice.
Kwinta
Przemko
P
Klinika Chorób Dzieci Katedry Pediatrii Wydziału Lekarskiego Uniwersytetu Jagiellońskiego, 30-663 Kraków, ul. Wielicka 265. kwintap@mp.pl
Tomasik
Tomasz
T
Mitkowska
Zofia
Z
Pietrzyk
Jacek J
JJ
Kruczek
Piotr
P
D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D016753:Interleukin-10 / Q000378:metabolism*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000628:therapy; D018805:Sepsis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D013997:Time Factors
D016753:Interleukin-10