Hormonal therapies in acne.
Hormones, in particular androgen hormones, are the main cause of acne in men, women, children and adults, in both normal states and endocrine disorders. Therefore, the use of hormonal therapies in acne is rational in concept and gratifying in practice. Although non-hormonal therapies enjoy wide usage and continue to be developed, there is a solid place for hormonal approaches in women with acne, especially adult women with persistent acne. This review covers the physiological basis for hormonal influence in acne, the treatments that are in use today and those that show promise for the future. The main treatments to be discussed are oral contraceptives androgen receptor blockers like spironolactone and flutamide, inhibitors of the enzyme 5 alpha-reductase and topical hormonal treatments.
Shaw
James C
JC
Division of Dermatology, Toronto Western Hospital, East Wing 8-517, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada. jc.shaw@utoronto.ca
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000287:Administration, Topical; D000311:Adrenal Glands / Q000378:metabolism; D000726:Androgen Antagonists / Q000627:therapeutic use; D059002:Androgen Receptor Antagonists; D000728:Androgens / Q000378:metabolism*; D042944:Cholestenone 5 alpha-Reductase; D003276:Contraceptives, Oral / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D011944:Receptors, Androgen / Q000378:metabolism; D012627:Sebaceous Glands / Q000378:metabolism
D000726:Androgen Antagonists; D059002:Androgen Receptor Antagonists; D000728:Androgens; D003276:Contraceptives, Oral; D004791:Enzyme Inhibitors; D011944:Receptors, Androgen; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase