Alpha-blockers: an effective treatment for prostatitis?
Chronic prostatitis is a multifaceted problem affecting men that is both poorly understood and poorly treated. It is inevitable, therefore, that no single treatment will benefit all patients. However, data suggest that some patients' problems can be treated effectively with alpha-blockers. The prostate is rich in alpha-adrenergic receptors, and some urodynamic studies have shown a failure of the bladder neck to relax during voiding. Other studies have demonstrated turbulent flow in the prostate leading to prostatic duct reflux. Because urine is acidic, reflux into the prostatic ducts will cause inflammation and pain. Thus alpha-blockers are an effective treatment for men with prostatitis caused by dysfunctional voiding.
Caropreso
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Department of Surgery, Division of Urology, University of Wisconsin Medical School, G5/341 CSC, 600 Highland Avenue, Madison, WI 53792, USA.
Moon
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D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000465:Algorithms; D002908:Chronic Disease; D006801:Humans; D008297:Male; D011472:Prostatitis / Q000145:classification / Q000188:drug therapy* / Q000503:physiopathology
D000317:Adrenergic alpha-Antagonists