The T-box family.
Transcription factors of the T-box family are required both for early cell-fate decisions, such as those necessary for formation of the basic vertebrate body plan, and for differentiation and organogenesis. When mutated, T-box genes give dramatic phenotypes in mouse and zebrafish, and they have been implicated both in fundamentals of limb patterning and in a number of human congenital malformations such as Holt-Oram, ulnar-mammary and DiGeorge syndromes, as well as being amplified in a subset of cancers. Genes encoding members of the T-box family have recently been shown to comprise approximately 0.1% of genomes as diverse as those of nematodes and humans and have been identified in a wide variety of animals from ctenophores (comb jellies) to mammals; they are, however, completely absent from genomes from other organisms (such as the model plant Arabidopsis thaliana).
Wilson
Val
V
Department of Genetics, 220 Fordham Hall, University of North Carolina, Chapel Hill, NC 27599-3280, USA. frank_conlon@med.unc.edu
Conlon
Frank L
FL
D000818:Animals; D019295:Computational Biology; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000235:genetics; D005809:Genes, Regulator / Q000235:genetics; D006801:Humans; D005810:Multigene Family / Q000235:genetics*; D009928:Organ Specificity / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D020825:T-Box Domain Proteins / Q000737:chemistry / Q000235:genetics*
D020825:T-Box Domain Proteins