Papillomavirus E1 proteins: form, function, and features.
The E1 proteins are the essential origin recognition proteins for papillomavirus (PV) replication. E1 proteins bind to specific DNA elements in the viral origin of replication and assemble into hexameric helicases with the aid of a second viral protein, E2. The resultant helicase complex initiates origin DNA unwinding to provide the template for subsequent syntheses of progeny DNA. In addition to ATP-dependent helicase activity, E1 proteins interact with and recruit several host cell replication proteins to viral origin, including DNA polymerase alpha and RPA. This review will compare the basic structures and features of the human (HPV) and bovine (BPV1) papillomaviruses with an emphasis on mechanisms of replication function.
Wilson
Van G
VG
Department of Medical Microbiology and Immunology, College of Medicine, Texas A & M University System Health Science Center, College Station 77843-1114, USA. v-wilson@tamu.edu
West
Michael
M
Woytek
Kelly
K
Rangasamy
Dandapani
D
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D052688:Bovine papillomavirus 1 / Q000235:genetics / Q000378:metabolism*; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000378:metabolism*; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; C069814:E1 protein, Bovine papillomavirus; C084304:E1 protein, Human papillomavirus type 11; D014764:Viral Proteins; D000251:Adenosine Triphosphatases; D004265:DNA Helicases