A case of mixed membranous nephropathy and purpura nephritis.
We report the case of a 71-year-old man with mixed glomerular lesions, membranous and necrotizing changes. The patient had abdominal pain and purpurat on the extremities and trunk, followed by melena, and after admission to hospital, proteinuria and occult blood were noted. Laboratory findings were negative for autoimmune disease and viral hepatitis. Renal biopsy showed segmental necrotizing changes and mesangial proliferation with spike formation. Immunofluorescence revealed a granular deposition of IgA predominantly in the mesangial area in contrast to the granular IgG deposition along the glomerular capillary loops. Moreover, electron-microscopically, mesangial as well as subepithelial electron-dense deposits were observed. These data suggest that the patient had 2 distinct types of glomerulonephritis simultaneously: idiopathic membranous nephropathy and purpura nephritis.
Ehara
T
T
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan. eharat@sch.md.shinshu-u.ac.jp
Muramatsu
T
T
Shigematsu
H
H
D000368:Aged; D015433:Glomerulonephritis, Membranous / Q000473:pathology* / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000473:pathology* / Q000628:therapy; D008297:Male