Hypersensitivity in functional gastrointestinal disorders.
Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception-that is, its relation to clinical symptoms-remains unclear. Data indicate that sensory dysfunction is associated with altered reflex activity. Hence evidence of combined sensory-reflex dysfunction as a common pathophysiological mechanism in various functional gastrointestinal disorders would suggest that they are different forms of the same process. Altered reflex activity and altered conscious perception of gastrointestinal stimuli may combine to differing degrees, and their interaction may produce clinical symptoms.
Azpiroz
F
F
Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Spain. fernando.azpiroz@wol.es
D003109:Colonic Diseases, Functional / Q000503:physiopathology*; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D009619:Nociceptors / Q000502:physiology; D012021:Reflex, Abnormal / Q000502:physiology*; D012677:Sensation / Q000502:physiology*; D017833:Visceral Afferents / Q000503:physiopathology*