title: Metabolic engineering by genome shuffling.
authors.forename: Gregory
authors.initials: G
authors.lastname: Stephanopoulos
mesh_terms: D002384:Catalysis; D019020:Directed Molecular Evolution / Q000379:methods; D019143:Evolution, Molecular; D005285:Fermentation; D015964:Gene Expression Regulation, Bacterial; D005818:Genetic Engineering / Q000379:methods*; D024861:Genetic Enhancement / Q000379:methods*; D014644:Genetic Variation; D016680:Genome, Bacterial; D019344:Lactic Acid / Q000096:biosynthesis*; D007778:Lactobacillus / Q000201:enzymology* / Q000235:genetics* / Q000254:growth & development; D008954:Models, Biological; D008967:Molecular Biology / Q000379:methods*; D009154:Mutation / Q000235:genetics; D030781:Organisms, Genetically Modified / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D011522:Protons; D011995:Recombination, Genetic; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism; D015645:Tylosin / Q000096:biosynthesis
chemical_list: D011522:Protons; D019344:Lactic Acid; D015645:Tylosin