title: Adult T-cell leukemia/lymphoma in Jujuy, north-west Argentina.
abstract: Human T-cell leukemia virus type 1 (HTLV-1) infection is prevalent in native Americans living in the Andes. Some of their malignant lymphomas (ML) show a peculiar histology suggestive of adult T-cell leukemia/lymphoma (ATLL). To determine whether ML resembling ATLL are indeed ATLL, re-analysis of 34 cases occurring in Jujuy, a province of Argentina, was conducted, concentrating on immunological phenotype, integration of HTLV-1 proviral DNA, expression of HTLV-1 p40Tax and p27Rex, and infection of Epstein-Barr virus (EBV). The ML were 22 cases of mature peripheral T-cell and natural killer (NK)-cell neoplasm (mT/NKN), 11 B-cell malignant neoplasms and one Hodgkin's lymphoma. Polymerase chain reaction against the HTLV-1 proviral DNA, using DNA extracted from paraffin sections, indicated integration of the HTLV-1 proviral DNA in three cases of eight mT/NKN. Two other cases of mT/NKN were positive for anti-HTLV-1 antibodies. Expression of p40Tax and p27Rex was detected in all five of these mT/NKN cases associated with HTLV-1. As such, these five mT/NKN were rediagnosed as ATLL. In situ hybridization signals for EBV-encoded small nuclear early region-1 were detected in nine cases of mT/NKN, of which five cases of NK-cell lymphoma were found to have cytoplasmic CD3 expression, a CD56 phenotype and positivity of TIA1. According to the new World Health Organization classification, the mT/NKN class includes five cases of ATLL and five cases of NK-cell lymphomas. The five cases of ATLL were of native American extraction from an HTLV-1-endemic area around Jujuy, north-west Argentina.
authors.affiliation: Department of Pathology, Pablo Soria Hospital, Argentina.
authors.forename: Oscar
authors.initials: O
authors.lastname: Marin
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Hasui
authors.forename: Carlos
authors.initials: C
authors.lastname: Remondegui
authors.forename: Eiichi
authors.initials: E
authors.lastname: Sato
authors.forename: Moe Moe
authors.initials: MM
authors.lastname: Aye
authors.forename: Norihiro
authors.initials: N
authors.lastname: Takenouchi
authors.forename: Shuji
authors.initials: S
authors.lastname: Izumo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
mesh_terms: D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D005260:Female; D016356:Gene Products, tax / Q000032:analysis; D016355:Genes, pX; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies
chemical_list: D004279:DNA, Viral; C099537:Epstein-Barr virus encoded RNA 1; D016356:Gene Products, tax; D012367:RNA, Viral