title: NAD-glycohydrolase production and speA and speC distribution in Group A streptococcus (GAS) isolates do not correlate with severe GAS diseases in the Australian population.
abstract: Streptococcus pyogenes isolates from a tropical region and a subtropical region of Australia with high and low incidences of severe streptococcal diseases, respectively, were analyzed for speA, speB, and speC gene distributions and NAD-glycohydrolase expression. No direct correlation of these characteristics with a propensity to cause invasive diseases was observed.
authors.affiliation: Menzies School of Health Research, Darwin, Australia.
authors.forename: Armando
authors.initials: A
authors.lastname: DelVecchio
authors.forename: Michael
authors.initials: M
authors.lastname: Maley
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Currie
authors.forename: K S
authors.initials: KS
authors.lastname: Sriprakash
mesh_terms: D001315:Australia / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics*; D005098:Exotoxins / Q000235:genetics*; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009244:NAD+ Nucleosidase / Q000096:biosynthesis*; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000201:enzymology* / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D005098:Exotoxins; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin; D009244:NAD+ Nucleosidase