title: Biochemistry. Intramembrane proteases--mixing oil and water.
authors.affiliation: Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. mwolfe@rics.bwh.harvard.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolfe
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Selkoe
mesh_terms: D020816:Amino Acid Motifs; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D001665:Binding Sites; D002384:Catalysis; D020134:Catalytic Domain; D002462:Cell Membrane / Q000201:enzymology*; D019281:Dimerization; D010450:Endopeptidases / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008051:Lipid Bilayers; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D009154:Mutation; D053764:Presenilin-1; D053766:Presenilin-2; D021382:Protein Sorting Signals; D051880:Receptors, Notch; D011994:Recombinant Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; D008051:Lipid Bilayers; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D021382:Protein Sorting Signals; D051880:Receptors, Notch; D011994:Recombinant Proteins; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C460085:signal peptide peptidase; C509280:BACE1 protein, human