A novel approach for the preparation of highly loaded polymeric controlled release dosage forms of diltiazem HCl and diclofenac sodium.
In this investigation, modified-release dosage forms of diltiazem HCl (DT) and diclofenac sodium (DS) were prepared. The development work comprised two main parts: (a) loading the drug into ethylene vinyl acetate (EVA) polymer, and (b) generation of a non-uniform concentration distribution of the drug within the polymer matrix. Phase separation technique was successfully used to load DT and DS into the polymer at significantly high levels, up to 81 and 76%, respectively. Size diameter of the resultant microspheres was between 1.6 and 2.0mm. Controlled-extraction of loaded microspheres and high vacuum freeze-drying were used to generate the non-uniform concentration distribution and to immobilize the new drug distribution within the matrix. Parameters controlling the different processes were investigated, and hence optimal processing conditions were used to prepare the dosage forms. Rates of drug release from the two dosage forms in water and in media having different pH were found to be constant for an appreciable length of time (>8h) followed by a slow decline; a characteristic of a non-Fickian diffusion process. Scanning electron microscopy studies suggested that the resultant release behavior was the outcome of the combined effects of the non-uniform distribution of the drug in the matrix and the apparent changes in the pores and surface characteristics of the microspheres. Comparison of release rate-time plots of dissolution data of marketed products with the newly developed dosage forms indicated the ability of the latter to sustain more zero order release.
Kakish
Hanan F
HF
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Tashtoush
Bassam
B
Ibrahim
Hussein G
HG
Najib
Naji M
NM
D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D004008:Diclofenac / Q000737:chemistry* / Q000493:pharmacokinetics; D004110:Diltiazem / Q000737:chemistry* / Q000493:pharmacokinetics; D004304:Dosage Forms; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical / Q000379:methods
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D011108:Polymers; D004008:Diclofenac; D004110:Diltiazem