Dysmetabolic syndrome: multiple risk factors for premature adult disease in an adolescent girl.
The clinical diagnosis of dysmetabolic syndrome in an adult defines a patient with abnormal glucose metabolism (or diabetes), hypertension, hyperlipidemia, and obesity. This disorder accelerates atherosclerosis and significantly raises the risk for cardiovascular events. With the marked rise in the prevalence of obesity in childhood, obesity-linked risk factors are being expressed at young ages. The case of a 12-year-old girl with dysmetabolic syndrome is described and discussed. Emerging clinical data now indicate that the presence of 1 risk factor for cardiovascular disease in an overweight child should prompt screening for additional clinical abnormalities, with the aim of finding treatable disorders.
Falkner
Bonita
B
Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. bonita.falkner@mail.tju.edu
Hassink
Sandra
S
Ross
Judith
J
Gidding
Samuel
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002318:Cardiovascular Diseases / Q000175:diagnosis; D002648:Child; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis / Q000453:epidemiology; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology; D012307:Risk Factors