title: A matter of life and death.
abstract: We propose that deregulation of proliferation, together with a reduction in apoptosis, creates a platform that is both necessary and can be sufficient for cancer. The secondary traits of diverse neoplasms are a consequence of cell proliferation, tissue expansion, and other outcomes of this platform.
authors.affiliation: La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Green
authors.forename: Gerard I
authors.initials: GI
authors.lastname: Evan
mesh_terms: D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D002470:Cell Survival; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction