title: Association between intercellular adhesion molecule-1 E/K gene polymorphism and probable vascular dementia in humans.
abstract: Intercellular adhesion molecule-1 (ICAM-1) is implicated in the pathogenesis of ischemic cardiovascular disorders, including cerebral ischemia. A common polymorphism of the ICAM-1 gene (K469E) has been recently reported. In this case-control study, we evaluated the association between this polymorphism and vascular dementia (VD) by studying 107 patients affected by probable VD and 115 age- and sex-matched controls. The frequency of the EE genotype was significantly higher in VD patients than controls (P=0.009). Logistic regression analysis indicated that the presence of the EE genotype significantly increased the risk of VD (odds ratio 3.25, P=0.024). Our findings support the hypothesis that ICAM-1 plays a role in the physiopathology of ischemic cerebrovascular disorders and suggest that genetic polymorphisms of ICAM-1 might be clinically important in the development and progression of neurodegenerative diseases.
authors.affiliation: Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy. rob_pola@hotmail.com
authors.forename: Roberto
authors.initials: R
authors.lastname: Pola
authors.forename: Andrea
authors.initials: A
authors.lastname: Flex
authors.forename: Eleonora
authors.initials: E
authors.lastname: Gaetani
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Papaleo
authors.forename: Demetrio
authors.initials: D
authors.lastname: De Martini
authors.forename: Laura
authors.initials: L
authors.lastname: Gerardino
authors.forename: Michele
authors.initials: M
authors.lastname: Serricchio
authors.forename: Paolo
authors.initials: P
authors.lastname: Pola
authors.forename: Roberto
authors.initials: R
authors.lastname: Bernabei
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015140:Dementia, Vascular / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D018799:Intercellular Adhesion Molecule-1