Stimulation of B lymphocytes, macrophages, and dendritic cells by protozoan DNA.
This review summarizes recent work from our laboratory demonstrating the activation of B lymphocytes, macrophages and dendritic cells by DNA from three different protozoan parasites of cattle and humans that is qualitatively similar to the now well-described effects of CpG-containing bacterial DNA. This novel mechanism of protozoan parasite recognition by the innate immune system could facilitate recovery from acute infection or contribute to infection-related pathology.
Brown
Wendy C
WC
Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA. wbrown@vetmed.wsu.edu
Corral
Ricardo S
RS
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology; D018899:CpG Islands / Q000235:genetics / Q000276:immunology; D016054:DNA, Protozoan / Q000235:genetics / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D056890:Eukaryota / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology*; D011528:Protozoan Infections / Q000276:immunology*
D016054:DNA, Protozoan