title: New-generation pulsed carbon dioxide laser: comparative effects on vocal fold wound healing.
abstract: We investigated wound healing of vocal fold mucosal excisions using a canine model, comparing cold steel, the continuous wave (CW) carbon dioxide (CO2) laser, and a new, microsecond-pulsed CO2 laser. The thermal injury to the surrounding normal tissues produced by the laser increases the risk for scar formation and poor functional voice outcome. This injury may be reduced with a pulsed CO2 laser. Acute, 2-week, and 6-week studies of 15 dogs were made with blinded observers and nonparametric statistical analyses. Histologic comparison showed less thermal injury and scar formation in the vocal folds treated with the pulsed CO2 laser than with the CW CO2 laser. Functional outcomes as studied with laryngeal videostroboscopy revealed better vibratory characteristics with the pulsed CO2 laser as compared with the CW CO2 laser. No differences were seen on these measures between the pulsed laser and cold techniques. Pulsed CO2 lasers may offer the ease of laser laryngology and the superior wound healing of cold steel.
authors.affiliation: Department of Otolaryngology, Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.
authors.forename: C Gaelyn
authors.initials: CG
authors.lastname: Garrett
authors.forename: Lou
authors.initials: L
authors.lastname: Reinisch
mesh_terms: D000818:Animals; D004285:Dogs; D053685:Laser Therapy; D013997:Time Factors; D014827:Vocal Cords / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology*