title: A carcinosarcoma/sarcomatoid carcinoma arising in a urinary bladder diverticulum.
abstract: We describe an invasive polypoid carcinosarcoma/sarcomatoid carcinoma arising within a urinary bladder diverticulum in a 65-year-old patient with synchronous, moderately differentiated prostatic adenocarcinoma. Histologically, the diverticular tumor exhibits an admixture of different morphologic components, including invasive high-grade urothelial carcinoma, malignant glandular structures in a cellular background of malignant spindle cells, and areas formed exclusively by spindle and pleomorphic cells. There was full-thickness involvement of the diverticulum with extension of the tumor into the perivesical fat and ipsilateral seminal vesicle. In view of the early invasive behavior of carcinosarcoma/sarcomatoid carcinoma combined with the paucity of the muscular layer in the diverticulum wall, a graver prognosis was expected for this aggressive tumor that occurred in this unusual site.
authors.affiliation: Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Atilla
authors.initials: A
authors.lastname: Omeroglu
authors.forename: Gladell P
authors.initials: GP
authors.lastname: Paner
authors.forename: Eva M
authors.initials: EM
authors.lastname: Wojcik
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Siziopikou
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002296:Carcinosarcoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D004240:Diverticulum / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D001743:Urinary Bladder / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor