title: Botulinum B treatment of the glabellar and frontalis regions: a dose response analysis.
abstract: BACKGROUND
  Botulinum toxin injections represent the most commonly performed cosmetic procedure in the US. There is an enormous reported experience documenting the efficacy of botulinum toxin A injections. There is very limited published information about the efficacy and appropriate dosage of botulinum toxin B injections.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the dosage response and side effect profile of botulinum toxin B injections.
  
  
  METHODS
  Twenty-six subjects received botulinum B injections to their glabellar area. Eighteen subjects received botulinum B injections to their frontalis region. Three different dosages were used. In the glabellar treated subjects the low dose group received a total of 1875 units; the medium dose group received a total of 2500 units; and the high dose group received a total of 3125 units. In the frontalis treated group, the low dose group received a total of 2250 units; the medium dose group received a total of 3000 units; and the high dose group received a total of 3750 units of botulium B toxin.
  
  
  RESULTS
  In the glabellar group, most subjects showed some evidence of paralysis at 2 months. Only in the high dose group did a significant cadre of treated subjects still show a significant response at 3 months after treatment. In the frontalis group, response was often still seen at 2 months. However, at 3 months most subjects showed no continued effect from botulinum B toxin.
  
  
  CONCLUSIONS
  Botulinum B toxin injections represent an alternative to botulinum A treatment for glabellar and frontalis hyperkinetic wrinkles. At the doses utilized in this study, the effect does not generally appear to last as long as has been reported with botulinum A injections. However, the onset of action may be sooner with botulinum B injections.
authors.affiliation: Department of Dermatology of Mt. Sinai School of Medicine, New York, NY, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Spencer
authors.forename: Marsha
authors.initials: M
authors.lastname: Gordon
authors.forename: David J
authors.initials: DJ
authors.lastname: Goldberg
mesh_terms: D000328:Adult; D001905:Botulinum Toxins / Q000008:administration & dosage* / Q000627:therapeutic use; D019274:Botulinum Toxins, Type A; D004305:Dose-Response Relationship, Drug; D005260:Female; D005546:Forehead; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D015595:Skin Aging / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: C096323:rimabotulinumtoxinB; D008666:Metalloendopeptidases; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A