[Effects of Squama manitis on cardiac systolic function and platelet aggregation].
OBJECTIVE
To study the effect of Squama Manitis(S. M.) on cardiac function and platelet aggregation in vitro.


METHODS
Isolated working rat hearts were prepared, and cardiac performance was measured before and after adding S. M. in the Krebs-Hensleit(K-H) perfusion buffer. Controls with K-H buffer were also investigated. Rich platelet plasma and Poor platelet plasma were centrifuged from the blood of 15 patients with coronary heart disease. Each sample was divided into three parts for use by three groups: control, group of S. M. and group of aspirin. Platelet aggregation was stimulated by adenosine diphosphate.


RESULTS
LVSP, +dP/dtmax and CO of isolated working rat hearts were significantly increased after treating with S. M. liquor. S. M. had no obvious effect on -dP/dtmax and LVEDP. These parameters did not change significantly in the control. Percentages of platelet aggregation were significantly lower in the group of S. M. and the group of aspirin as compared with the control.


CONCLUSIONS
S. M. increases cardiac systolic function, has positive inotropic effect on myocardium and inhibits platelet aggregation.
Wen
X
X
Liyuan Hospital, Tongji Medical University, Wuhan 430077.
Xu
B
B
Liu
H
H
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003327:Coronary Disease / Q000097:blood; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008419:Materia Medica / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D002316:Cardiotonic Agents; D008419:Materia Medica; D010975:Platelet Aggregation Inhibitors