A critical assessment of the neurodestructive and neuroprotective effects of nitric oxide.
Whether nitric oxide is cytodestructive or cytoprotective is of obvious clinical importance. The debate on this subject in the past decade has generated much "heat and light". This paper focuses on the actions of NO on the nervous system and reexamines the controversial issue and the contribution of the authors and their colleagues in the light of recent findings. We also report new findings, critically assesses previous experimental data, and share perspectives on this important subject.
Leong
Seng-Kee
SK
Department of Anatomy, National University of Singapore, Singapore. antlsk@nus.edu.sg
Ruan
Run-Sheng
RS
Zhang
Zhi
Z
D000818:Animals; D004791:Enzyme Inhibitors / Q000378:metabolism; D006801:Humans; D019331:NG-Nitroarginine Methyl Ester / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D018696:Neuroprotective Agents; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism
D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester