title: A direct comparison of the antigen-specific antibody profiles of intravenous immunoglobulins derived from US and UK donor plasma.
abstract: OBJECTIVE
  Intravenous immunoglobulin (IVIG) is used in a range of immunodeficiency states that require a broad spectrum of protective antibodies to a range of common pathogens. A comparison of the antigen-specific antibody profile of preparations of an IVIG (Vigam) derived from US and UK sourced plasma was performed, and these preparations were also compared with three other IVIG products from different manufacturers.
  
  
  METHODS
  Antibodies against a range of bacterial and viral pathogens were measured by immunoassay.
  
  
  RESULTS
  Similar profiles were found for Vigam made from UK and US source plasma and also for the other three IVIGs tested, but some specific differences were observed.
  
  
  CONCLUSIONS
  IVIG preparations have a similar therapeutic spectrum of antibodies when prepared from plasma sourced either from the UK or the US.
authors.affiliation: Bio Products Laboratory, Elstree, Herts., UK.
authors.forename: P
authors.initials: P
authors.lastname: Matejtschuk
authors.forename: K
authors.initials: K
authors.lastname: Chidwick
authors.forename: A
authors.initials: A
authors.lastname: Prince
authors.forename: J E
authors.initials: JE
authors.lastname: More
authors.forename: D
authors.initials: D
authors.lastname: Goldblatt
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D000918:Antibody Specificity; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000032:analysis; D016756:Immunoglobulins, Intravenous / Q000032:analysis* / Q000276:immunology; D017186:Titrimetry; D006113:United Kingdom; D014481:United States
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007132:Immunoglobulin Isotypes; D016756:Immunoglobulins, Intravenous