title: [Catastrophic antiphospholipid syndrome. Report of two cases].
abstract: The antiphospholopid syndrome has been associated with thromboembolic events, thrombocytopenia and fetal loss. Some patients with the antiphospholipid syndrome may develop an acutely catastrophic syndrome characterized by multiple vascular occlusions which often results in death. Most patients dye as a result of a combination of cardiac and pulmonary failure. Although trigger factors are present in a minority, in the majority the condition develops quite suddenly. Precipitating factors include infections and trauma (surgical). Treatment of the condition, once recognized, needs to be heroic. Plasmapheresis seems to be useful in several cases who had not responded to conventional therapy (heparin, steroids, immunosuppressive) directed against immunologically mediated intravascular thrombosis. We report here two cases of fatal catastrophic antiphospholipid syndrome and highlight the need for vigilance in the management of patients with antiphospholipid syndrome.
authors.affiliation: Laboratoire d'immunologie, Faculté de Médecine de Sousse.
authors.forename: Foued
authors.initials: F
authors.lastname: Ben Hadj Slama
authors.forename: Touhami
authors.initials: T
authors.lastname: Mahjoub
authors.forename: Samir
authors.initials: S
authors.lastname: Fejji
authors.forename: Amel
authors.initials: A
authors.lastname: Maaroufi
authors.forename: Amel
authors.initials: A
authors.lastname: Trabelsi
authors.forename: Fethi
authors.initials: F
authors.lastname: Amri
authors.forename: Chadia
authors.initials: C
authors.lastname: Laouani
mesh_terms: D000208:Acute Disease; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000473:pathology* / Q000628:therapy; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications; D008297:Male; D010956:Plasmapheresis; D011379:Prognosis; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology*