title: Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure.
abstract: The octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 (I), consisting of isonucleoside units 6'-O-allyl-4'-deoxy-4'-(nucleobase)-2',5'-anhydro-L-mannitol, was synthesized by the phosphotriester approach in solution phase. Based on CD spectra and capillary electrophoresis, it was confirmed that iso-oligomer I could form a parallel intermolecular G-quadruplex structure. K+, Na+ and Li+ can prompt the formation of G-quartet structures and stabilize them. The effective order of these cations is K+ > Na+ > Li+.
authors.affiliation: National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Liang Ren
authors.initials: LR
authors.lastname: Zhang
authors.forename: Ji Mei
authors.initials: JM
authors.lastname: Min
authors.forename: Li He
authors.initials: LH
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002942:Circular Dichroism; D019075:Electrophoresis, Capillary; D006151:Guanosine / Q000737:chemistry; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D010755:Organophosphates; D006151:Guanosine