title: Interactions between dead cells and dendritic cells in the induction of antiviral CTL responses.
abstract: Dendritic cells - professional antigen-presenting cells - are key players for activating adaptive immune responses against viruses. Apoptosis or lytic cell death often accompanies viral infection. Dendritic cells can acquire infected dead or dying cells as exogenous sources of antigens for presentation on MHC class I and II molecules to initiate T cell responses. This pathway of activating T cells may be critical for the development of effective antiviral immunity in vivo.
authors.affiliation: Laboratory of Molecular Neuro-Oncology, The Rockefeller University New York, New York, NY 10021, USA.
authors.forename: Jean François
authors.initials: JF
authors.lastname: Fonteneau
authors.forename: Marie
authors.initials: M
authors.lastname: Larsson
authors.forename: Nina
authors.initials: N
authors.lastname: Bhardwaj
mesh_terms: D017951:Antigen Presentation; D000956:Antigens, Viral / Q000276:immunology; D016923:Cell Death; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D011971:Receptors, Immunologic / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D011971:Receptors, Immunologic