Phagnalon rupestre as a source of compounds active on contact hypersensitivity.
The effect of Phagnalon rupestre MeOH extract on dinitrofluorobenzene- and sheep red blood cells-induced hypersensitivity was investigated. Eight compounds were identified: three dimethylallyl-hydroquinone glucosides (1 - 3), 3,5- and 4,5-di-O-caffeoylquinic acid methyl esters (4 and 5), their free carboxyl analogues (6 and 7), and luteolin 7-O-beta-glucoside (8). All were tested for dinitrofluorobenzene-induced contact hypersensitivity inhibitory activity. Flavonoid 8 was the most active (49 % and 79 % inhibition at 24 and 96 h, respectively). The hydroquinones 1, 2 and 3 were effective at 96 h after challenge (62 %, 73 % and 60 % inhibition, respectively), while some of the dicaffeoylquinic derivatives (4 and 7) produced slightly lower reduction of the inflammatory reaction.
Góngora
Luis
L
Giner
Rosa María
RM
Máñez
Salvador
S
Recio
María del Carmen
Mdel C
Ríos
José Luis
JL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D019659:Asteraceae; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000276:immunology; D004139:Dinitrofluorobenzene / Q000276:immunology; D004912:Erythrocytes / Q000166:cytology / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology; D008519:Medicine, Traditional; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012756:Sheep; D013030:Spain
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D004139:Dinitrofluorobenzene