title: Estrogen replacement therapy for Alzheimer disease in postmenopausal women.
abstract: OBJECTIVE
  To evaluate the clinical utility of oral conjugated equine estrogen in postmenopausal women with Alzheimer disease.
  
  
  METHODS
  Literature was identified through MEDLINE (1997-January 2002). Key search terms included Alzheimer disease, estrogen replacement therapy, and treatment.
  
  
  RESULTS
  Estrogen has been identified as a neuroprotective agent with possible application in degenerative disorders. Observational studies have demonstrated an association between estrogen replacement therapy and decreased incidence of Alzheimer disease. Two recent, controlled clinical trials have evaluated the role of oral conjugated estrogen in the treatment of Alzheimer disease.
  
  
  CONCLUSIONS
  Clinical trials indicate that oral conjugated equine estrogen is not an effective treatment for Alzheimer disease in postmenopausal women.
authors.affiliation: College of Pharmacy, Idaho State University, Campus Box 8356, Pocatello, ID 83209-8356, USA, cjnowens@msn.com
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Owens
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D016032:Randomized Controlled Trials as Topic; D017211:Treatment Failure
chemical_list: D004966:Estrogens, Conjugated (USP)