A multiantioxidant supplementation reduces damage from ischaemia reperfusion in patients after lower torso ischaemia. A randomised trial.
BACKGROUND
open repair of intra-abdominal aortic aneurysm (AAA) is associated with lower torso ischaemia and reperfusion.


OBJECTIVE
to examine the effect of antioxidants on the activation and sequestration of white blood cells and muscle injury during AAA repair.


METHODS
forty-two patients undergoing elective infrarenal aneurysm repair, were randomised to either standard therapy (22 patients) or standard therapy with additional multiantioxidant supplementation (20 patients). Vitamin E and C, Allopurinol, N-acetylcysteine and mannitol was administered perioperatively. White blood cell count (WBC), serum creatine kinase, aspartateaminotransferase, lactate and lipofuscine were measured.


RESULTS
WBC remained higher after reperfusion in the antioxidant group (p = 0.008). CK, ASAT and lipofuscine levels were significantly lower after reperfusion in the antioxidant group (p = 0.02, p = 0.018, p = 0.017).


CONCLUSIONS
multi-antioxidant supplementation was associated with a reduction in serum CK and ASAT after AAA repair. This is likely due to a reduction in oxidative stress and a decreased leucocyte sequestration and activation.
Wijnen
M H W A
MH
Department of Surgery, St. Joseph Hospital, Veldhoven, 5500 MB, The Netherlands.
Roumen
R M H
RM
Vader
H L
HL
Goris
R J A
RJ
D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000627:therapeutic use*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008062:Lipofuscin / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D015427:Reperfusion Injury / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014166:Transferases / Q000097:blood; D014815:Vitamins / Q000627:therapeutic use
D000975:Antioxidants; D016166:Free Radical Scavengers; D008062:Lipofuscin; D014815:Vitamins; D014166:Transferases