Synthesis and biodistribution of a new 99mTc nitrido complex as a potential myocardial and cerebral imaging agent.
The bis(N-methyl, N-cyclohexyl dithiocarbamato) nitrido technetium-99m complex [99mTcN(MECHDTC)2] (MECHDTC: N-methyl, N-cyclohexyl dithiocarbamato) has been synthesized through a ligand-exchange reaction. The two-step procedure consisted of an initial reaction of 99mTcO4- with succinic dihydrazide in the presence of stannous chloride as reducing agent and propylenediamine tetraacetic acid as complexant, and successive addition of sodium salt of N-methyl, N-cyclohexyl dithiocarbamate. The radiochemical purity of the complex was over 90%, as measured by thin layer chromatography. No decomposition of the complex at room temperature was observed over a period of 6 h. Its partition coefficient indicated that it was a lipophilic complex. The electrophoresis results showed that the complex was neutral. Biodistribution in mice showed that the complex accumulated in the heart and brain with high uptake. The heart/blood, heart/lung and brain/blood ratios were 5.55, 2.11 and 1.10, respectively, at 30 min post-injection, suggesting that this compound is a potential myocardial and cerebral imaging agent.
Zhang
JunBo
J
Department of Chemistry, Beijing Normal University, People's Republic of China. zhjunbo0515@sina.com
Wang
XueBin
X
Li
ChunYun
C
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006321:Heart / Q000000981:diagnostic imaging*; D007202:Indicators and Reagents; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D013667:Technetium / Q000493:pharmacokinetics; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013859:Thiocarbamates; C465550:bis(N-methyl,N-cyclohexyldithiocarbamato)nitrido technetium-99m complex; D013667:Technetium