title: Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease.
abstract: Oxidative stress was presented to play an important role in the pathogenesis of Alzheimer's disease (AD), especially in the early evolution of AD amyloidogenesis and not only as a consequence thereof. The effect of oxidative stress catalysed by transition metals appears to have a critical relevance in AD. Metal-ion homeostasis is severely dysregulated in AD and it was found that experimentally induced disturbances in the homeostasis of Zn(II) and Cu(II) affect the amyloid precursor protein (APP) metabolism. APP itself binds Zn(II) and Cu(II) at nanomolar concentrations and an altered APP metabolism or expression level is believed to result in neurotoxic processes.
authors.affiliation: ZMBH--Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany. g.multhaup@zmbh.uni-heidelberg.de
authors.forename: Gerd
authors.initials: G
authors.lastname: Multhaup
authors.forename: Stefan
authors.initials: S
authors.lastname: Scheuermann
authors.forename: Andrea
authors.initials: A
authors.lastname: Schlicksupp
authors.forename: Andreas
authors.initials: A
authors.lastname: Simons
authors.forename: Markus
authors.initials: M
authors.lastname: Strauss
authors.forename: André
authors.initials: A
authors.lastname: Kemmling
authors.forename: Christian
authors.initials: C
authors.lastname: Oehler
authors.forename: Roberto
authors.initials: R
authors.lastname: Cappai
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Pipkorn
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Bayer
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D003300:Copper / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D017382:Reactive Oxygen Species; D003300:Copper