title: Prevalence of the fsr locus in Enterococcus faecalis infections.
abstract: The fsr locus of Enterococcus faecalis confers virulence in animal models. A retrospective analysis of fsr prevalence in diverse E. faecalis clinical isolates demonstrated fsr in all endocarditis isolates versus 53% of stool isolates (P = 0.005). This supports a role for fsr-mediated virulence in the pathogenesis of enterococcal infections in humans.
authors.affiliation: Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA. spillai@caregroup.harvard.edu
authors.forename: S K
authors.initials: SK
authors.lastname: Pillai
authors.forename: G
authors.initials: G
authors.lastname: Sakoulas
authors.forename: H S
authors.initials: HS
authors.lastname: Gold
authors.forename: C
authors.initials: C
authors.lastname: Wennersten
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
authors.forename: R C
authors.initials: RC
authors.lastname: Moellering
authors.forename: R T
authors.initials: RT
authors.lastname: Inouye
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D004697:Endocarditis, Bacterial / Q000382:microbiology; D013293:Enterococcus faecalis / Q000235:genetics* / Q000472:pathogenicity*; D005798:Genes, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D012189:Retrospective Studies; D014774:Virulence / Q000235:genetics
chemical_list: C409033:AgrCfs protein, Enterococcus faecalis; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C409031:FsrA protein, Enterococcus faecalis; C409032:FsrB protein, Enterococcus