Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.
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Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.
Bernstein
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Brynes
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D018426:SEER Program; D013584:Sarcoma, Synovial / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D014178:Translocation, Genetic; D014960:X Chromosome / Q000235:genetics*