title: [Serum zinc concentration with reference to other markers of continuous ambulatory peritoneal dialysis patients status].
abstract: The aim of our studies included measurement of serum Zn level in CAPD patients with the subsequent evaluation of relations between serum Zn and markers of nutrition, dietary intake, markers of acute phase reaction, CAPD adequacy, nitrogen balance as well as routine clinical and laboratory data. The study was performed in 81 patients treated with CAPD for up to 3 years (12 3-month study periods). Mean serum Zn concentration was 12.2 +/- 1.8 mumol/l and was decreased in 16% of patients. Positive correlation was shown between serum Zn level and prealbumin, iron, transferrin saturation, haemoglobin, mean corpuscular haemoglobin concentration and dialysis duration. Negative correlation was shown between serum Zn level and patients age as well as daily influent and effluent volumes, what means that patients in age over 65 years and those using daily inflow or outflow dialysate volume greater than 12.7 and 12.9 I, respectively, are at risk of Zn deficiency. Dietary Zn intake (9.9 +/- 2.5 mg/day) was in 96% of patients lower than that recommended for CAPD patients. Relation between Zn intake and ferritin, total cholesterol and vitamin E in serum as well as HDL-/total cholesterol ratio was shown. Our results indicate that approx. 16% of CAPD patients need Zn supplementation. Serum Zn level in CAPD patients shows a beneficial effect on serum markers of iron metabolism, blood morphology indices, serum lipid profile and increased serum vitamin E level.
authors.affiliation: Katedra i Klinika Nefrologii Akademii Medycznej w Poznaniu.
authors.forename: Irena
authors.initials: I
authors.lastname: Mariak
authors.forename: Alicja E
authors.initials: AE
authors.lastname: Grzegorzewska
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012307:Risk Factors; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood* / Q000172:deficiency
chemical_list: D015415:Biomarkers; D015032:Zinc