Interleukin-2 receptor serum concentrations in normal pregnancy and pre-eclampsia.
The purpose of this research was to assess interleukin-2 receptor serum levels in normal pregnancy and pre-eclampsia. Sera from 90 healthy pregnant women (30 for each trimester), 30 with pre-eclampsia and a group of 30 healthy non-pregnant were analyzed. Soluble interleukin-2 receptor was measured by specific double antibody enzymatic immunoassay (ELISA). Results were: 267.5 +/- 12.3 (mean +/- s.e.m) pg/mL in the uncomplicated first trimester sample, 300.9 +/- 14.5 pg/mL in the second trimester and 248.8 +/- 12.5 pg/mL in the third. The non-pregnant control group had 443.7 +/- 39.6 pg/mL, significantly different from normal pregnancy in all trimesters (p < 0.001). The concentration in pre-eclamptic patients was 382.2 +/- 24.2 pg/mL, with p < 0.01 with regard to the normal third trimester group. The conclusion is that interleukin-2 receptor serum levels diminish in normal pregnancy and rise in preeclampsia. The first finding seems to be a protective mechanism to the fetal allograft. The latter, point to increased cellular activity.
Romero-Adrián
Tania
T
Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Ruiz
Ana
A
Molina-Vílchez
Rafael
R
Estévez
Jesús
J
Atencio
Ricardo
R
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters; D017472:Receptors, Interleukin-1 / Q000097:blood*; D012995:Solubility
D017472:Receptors, Interleukin-1