title: [Anticancer chemotherapy containing cisplatin in patients with lung cancer and kidney function].
abstract: To carry out safe anticancer chemotherapy one should consider the kidney function. Insufficiency of that main organ responsible for drugs excretion, caused either by neoplastic disease or by chemotherapy, can diminish the possibility or even make impossible of carrying out a complete treatment cycle. The aim of our work was to evaluate the kidney function in patients with lung cancer during anticancer chemotherapy containing cisplatin. The tubular function was studied by estimation the activity of N-acetyl-beta-D-glucosaminidase in urine and glomerular function was studied by estimation the concentration of creatinine in urine, urea, uric acid and electrolytes in plasma. The observations have recorded that neoplastic process, as well as chemotherapy impaired the tubular function. It has showed that it does exist a necessity of detailed estimation of kidney excretory function before, during and after the end of anticancer therapy. Determination of NAG activity in urine may be helpful for the recognition of the patients at high nephrotoxicity risk, who need special care.
authors.affiliation: Katedra i Zakład Farmakologii Klinicznej AM we Wrocławiu.
authors.forename: Anna
authors.initials: A
authors.lastname: Wiela-Hojeńska
authors.forename: Ewa
authors.initials: E
authors.lastname: Passowicz-Muszyńska
authors.forename: Krystyna
authors.initials: K
authors.lastname: Orzechowska-Juzwenko
authors.forename: Renata
authors.initials: R
authors.lastname: Jankowska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Hurkacz
authors.forename: Józefa
authors.initials: J
authors.lastname: Unolt
authors.forename: Bozena
authors.initials: B
authors.lastname: Weryńska
authors.forename: Marcin
authors.initials: M
authors.lastname: Gołecki
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dyła
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D007677:Kidney Function Tests; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000503:physiopathology*; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D000118:Acetylglucosaminidase; D002945:Cisplatin