title: Mathematical model of a variable aperture mitral valve.
abstract: Previous models of pressure and flow waveforms during diastolic ventricular filling by the Waite et al. [2] described mitral valve behavior by a constant effective valve area and a constant valve impedance. A model to describe the opening process of the mitral valve was developed. The model is based on second-order dynamics and Bernoulli's equation. The earlier lumped variable model for diastolic filling was modified to reflect a variable mitral valve aperture. The combined model was calibrated using pressure and flow waveforms from porcine experiments and artificial transmitral pressure gradient waveforms. A comparison between the results of the combined model and the earlier fixed aperture model shows better agreement of experimental and simulated transmitral flow waveform in the combined model.
authors.affiliation: Department of Applied Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA.
authors.forename: Christoph Florian
authors.initials: CF
authors.lastname: Franck
authors.forename: Lee
authors.initials: L
authors.lastname: Waite
mesh_terms: D017097:Electric Impedance; D006439:Hemodynamics; D008943:Mitral Valve / Q000502:physiology*; D008955:Models, Cardiovascular