An addition to geographic hematology: chronic myeloproliferative diseases are infrequent in Mexican Mestizos.
BACKGROUND
The chronic myeloproliferative diseases (CMPDs) include chronic myelogenous leukemia (CML), primary (essential) thrombocythemia (PT), agnogenic myeloid metaplasia (AMM), and polycythemia vera (PV). Certain hematological malignancies have a different prevalence in our country than in countries with Caucasian populations. Data indicate that the prevalence of CML in our country is similar to that found in Caucasians; however, the prevalence of the other CMPDs has not been studied.


METHODS
In a total of 8069 individuals studied between June 1983 and March 2001 in the Centro de Hematologia y Medicina Interna de Puebla, we assessed the prevalence of CML, PT, AMM, and PV. Some of the clinical features of these individuals were also assessed.


CONCLUSIONS
Forty-nine patients with CML, 14 with PT, 7 with AMM, and 3 with PV were identified. The clinical presentations of these CMPDs were not different from those described in Caucasians.


CONCLUSIONS
We found that CML was more than 3 times more frequent than PT, that both PV and AMM were exceptional, and that PT, AMM, and PV were significantly less frequent in Mexican than in Caucasian populations (P < .01).
Ruiz-Argüelles
Guillermo J
GJ
Centro de Hematología y Medicina Interna de Puebla, PUE, México. gruiz1@puebla.megared.net.mx
López-Martínez
Briceida
B
Lobato-Mendizábal
Eduardo
E
Ruiz-Delgado
Guillermo J
GJ
D002908:Chronic Disease; D006801:Humans; D015994:Incidence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000453:epidemiology; D008800:Mexico / Q000453:epidemiology / Q000208:ethnology; D009196:Myeloproliferative Disorders / Q000453:epidemiology*; D011087:Polycythemia Vera / Q000453:epidemiology; D055728:Primary Myelofibrosis / Q000453:epidemiology; D044469:Racial Groups; D013920:Thrombocythemia, Essential / Q000453:epidemiology; D019371:Topography, Medical