[Bone dynamics of repair of mandibular defect with collagen/hydroxyapatite].
OBJECTIVE
To study the effect of collagen/hydroxyapatite(CHA) instead of autogenous bone transplantation on repairing the mandibular defects.


METHODS
Ten Chinese experimental minipigs were made 2 cm bone defects in diameter in the mandible. The experimental group was implanted CHA, while the control group was implanted autogenous bone. The basic parameters of bone dynamics were determined by bone metrology.


RESULTS
There was remarkable difference between the two groups in the mean distance and mineralization apposition rate of double label bands marked by tetracycline(P < 0.05), while the mean osteoid seam width and mineralization lag time had no remarkable difference(P > 0.05). It suggested that CHA had good osteogenesis. The collagen in CHA offered the condition of bone mineralization, and the mineralization peak of experimental group was present at 4 weeks earlier than that of control group (8 weeks).


CONCLUSIONS
CHA may be a substitute of autogenous bone transplantation in repairing the mandibular defects, and the second operation for offering the implanting bone is avoidable, therefore, CHA may be an ideal material to repair bone defects.
Cheng
Y H
YH
Department of Stomatology, 254th Hospital of PLA, Tianjin, P. R. China 300142.
Zhao
G J
GJ
Li
S L
SL
D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D002113:Calcification, Physiologic; D003094:Collagen / Q000627:therapeutic use*; D017886:Durapatite / Q000627:therapeutic use*; D008297:Male; D008337:Mandibular Fractures / Q000601:surgery*; D019736:Prostheses and Implants; D013556:Swine, Miniature
D018786:Bone Substitutes; D003094:Collagen; D017886:Durapatite