Estrogen and Alzheimer's disease.
The potential of estrogen as a therapeutic intervention in the prevention or treatment of neurodegenerative diseases has been the object of much research in the past five years. While clinical research has produced highly diverse results in different studies, basic research has uncovered a number ofmolecular mechanisms which dearly label estrogen as a neuroprotective agent. This short review summarizes the various research results that indicate how estrogen can be beneficial to neurons in Alzheimer's disease.
LeBlanc
Andrea
A
The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada. andrea.leblanc@mcgill.ca
D000109:Acetylcholine / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000682:Amyloid / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis; D018679:Cholinergic Agonists / Q000494:pharmacology; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009435:Synaptic Transmission
D000682:Amyloid; D000975:Antioxidants; D018679:Cholinergic Agonists; D004967:Estrogens; D018696:Neuroprotective Agents; D000109:Acetylcholine