title: In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
abstract: The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum. The ether extract from aerial parts of the plant collected in São Tomé e Príncipe, demonstrated good antiplasmodial activity (IC 50 on FCA strain: 0.75 microg/ml). A bioassay guided fractionation of this extract led to the isolation of the known sesquiterpene lactone tagitinin C as an active component against Plasmodium (IC 50 on FCA strain: 0.33 microg/ml), but also possessing cytotoxic properties (IC 50 on HTC-116 cells: 0.706 microg/ml).
authors.forename: Eric
authors.initials: E
authors.lastname: Goffin
authors.forename: Eric
authors.initials: E
authors.lastname: Ziemons
authors.forename: Patrick
authors.initials: P
authors.lastname: De Mol
authors.forename: Maria do Céu
authors.initials: Mdo C
authors.lastname: de Madureira
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Martins
authors.forename: Antonio Proença
authors.initials: AP
authors.lastname: da Cunha
authors.forename: Geneviève
authors.initials: G
authors.lastname: Philippe
authors.forename: Monique
authors.initials: M
authors.lastname: Tits
authors.forename: Luc
authors.initials: L
authors.lastname: Angenot
authors.forename: Michel
authors.initials: M
authors.lastname: Frederich
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D019659:Asteraceae; D002738:Chloroquine / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes; C012565:tagitinin; D002738:Chloroquine