Targeting the cell cycle for cancer therapy.
Most if not all neoplasias show a directly or indirectly deregulated cell cycle. Targeting its regulatory molecules, the cyclin-dependent kinases, as a therapeutic mode to develop new anticancer drugs, is being currently explored in both academia and pharmaceutical companies. The development of new compounds is being focused on the many features of the cell cycle with promising preclinical data in most fields. Moreover, a few compounds have entered clinical trials with excellent results maintaining the high hopes. Thus, although too early to provide a cell cycle target based new commercial drug, there is no doubt that it will be an excellent source of new anticancer compounds.
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Experimental Therapeutics Programme, Centro Nacional de Investigaciones Oncologicas (CNIO), c/Melchor Fernandez Almagro no. 3, 28029 Madrid, Spain. acrnero@cnio.es
D017502:Adenovirus E2 Proteins / Q000502:physiology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D003546:Cysteine Endopeptidases; D004268:DNA-Binding Proteins; D015195:Drug Design; D004341:Drug Evaluation; D050684:E2F Transcription Factors; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018816:Genes, cdc; D006801:Humans; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D046988:Proteasome Endopeptidase Complex; D014157:Transcription Factors / Q000502:physiology; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors / Q000502:physiology
D017502:Adenovirus E2 Proteins; D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; D009363:Neoplasm Proteins; D014157:Transcription Factors; D018844:Cyclin-Dependent Kinases; D020687:cdc25 Phosphatases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex