The apoptosis of the rat and mouse testicular cells could be induced by synthetic analogous of the prostaglandin F2 alpha?
Numerous actions of the synthetic analogous of the prostaglandins were used in human and veterinary therapy. The action of these analogous (even, initially the prostaglandins were put in evidence in the seminal plasma) on the male reproductive system are little known. This is the reason for our study, which tried to emphasize the effects of analogous of the prostaglandin F2 alpha on the apoptosis of the rat and mouse testicular cells. Optic active Cloprostenol and Cloprostenol Isopropyl ester, in a dose of 100 micrograms/kg/day induces significant histopathologic modifications in the testis of rats and mice. These changes are evident after 14 days of treatment, but especially after 28 days of treatment.
Indrei
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Dept. of Anatomy, School of Dental Medicine, University of Medicine and Pharmacy Gr.T. Popa Iaşi.
Zamfir
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Nechifor
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D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003008:Cloprostenol / Q000494:pharmacology*; D015237:Dinoprost / Q000494:pharmacology; D007985:Leydig Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D051381:Rats; D013737:Testis / Q000166:cytology*
D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol; D015237:Dinoprost