Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH).
To draw the cytogenetic profile of childhood and adult acute megakaryoblastic leukemia (M7), the Groupe Français de Cytogénétique Hématologique collected 53 cases of M7 (30 children and 23 adults). Compared to other acute myeloid leukemias, M7 is characterized by a higher incidence of abnormalities, a higher complexity of karyotypes, and a different distribution of abnormalities among children and adults. Nine cytogenetic groups were identified: normal karyotypes (group 1), patients with Down syndrome (group 2), numerical abnormalities only (group 3), t(1;22)(p13;q13) or OTT-MAL transcript (group 4), t(9;22)(q34;q11) (group 5), 3q21q26 (group 6), -5/del(5q) or -7/del(7q) or both (group 7), i(12)(p10) (group 8), and other structural changes (group 9). Groups 1, 2, 3, and 4 were exclusively composed of children (except one adult in group 3), whereas groups 5, 6, 7, and 8 were mainly made up of adults. The main clinical and hematologic features of these groups were described. No new recurrent abnormality was identified, but mapping of all breakpoints allowed us to specify several possible hot spots of rearrangement: 17q22-23, 11q14-21, 21q21-22, and 16q21-22-23. Although 90.5% of cases had no documented antecedent hematologic disorder or exposure to chemotherapy or radiotherapy, the morphologic and the cytogenetic findings indicated that M7 might be a secondary leukemia more often than suggested by preceding history, particularly among adults. The concurrent analyses of morphologic and cytogenetic data also led us to assume that the initial precursor involved might be more immature in adult than in childhood M7.
Dastugue
Nicole
N
Centre Hospitalier Universitaire (CHU), Toulouse, France. dastugue.n@chu-toulouse.fr
Lafage-Pochitaloff
Marina
M
Pagès
Marie-Pierre
MP
Radford
Isabelle
I
Bastard
Christian
C
Talmant
Pascaline
P
Mozziconacci
Marie Joelle
MJ
Léonard
Claude
C
Bilhou-Nabéra
Christelle
C
Cabrol
Christine
C
Capodano
Anne-Marie
AM
Cornillet-Lefebvre
Pascale
P
Lessard
Michel
M
Mugneret
Francine
F
Pérot
Christine
C
Taviaux
Sylvie
S
Fenneteaux
Odile
O
Duchayne
Eliane
E
Berger
Roland
R
D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002885:Chromosomes, Human, Pair 16; D002886:Chromosomes, Human, Pair 17; D002891:Chromosomes, Human, Pair 21; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D012189:Retrospective Studies