title: Synthesis and evaluation of poly(oxyethylene glycol) polymer (POP) supports.
abstract: Mono- and alpha,omega-bis-styryl-oligo(oxyethylene glycol) ethers have been constructed in an efficient two-step synthesis. From these precursors, poly(oxyethylene glycol) polymer (POP) supports of varying monomer and cross-linker composition have been produced. The swelling properties and mass-solvent uptake of these novel materials have been evaluated in a variety of solvents, demonstrating that POP supports exhibit enhanced solvent compatibilities over the commercial resins TENTA-GEL, ARGO-GEL, and Merrifield's resin. The utility of POP supports in solid-phase organic chemistry has also been demonstrated successfully. It is anticipated that these high-loading polymeric supports will have generic application in the solid-phase synthesis of combinatorial libraries and the in situ screening of these libraries in the aqueous environment of a bioassay.
authors.affiliation: Department of Chemical Engineering and Applied Chemistry, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.
authors.forename: Mark C
authors.initials: MC
authors.lastname: McCairn
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Tonge
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Sutherland