Virulence genes in Helicobacter pylori strains from West Bengal residents with overt H. pylori-associated disease and healthy volunteers.
We compared putative molecular markers of virulence (vacA, cagA, and iceA) of Helicobacter pylori strains isolated from 52 adult duodenal ulcer patients from West Bengal, India, with those of H. pylori strains isolated from 48 adult healthy volunteers from the same region. On the basis of genotyping by PCR, we conclude that the H. pylori strains isolated from the two study groups were indistinguishable and that there are geographic variations in the association of certain putative H. pylori virulence genes with clinical status.
Chattopadhyay
Santanu
S
National Institute of Cholera and Enteric Diseases, Calcutta, India.
Datta
Simanti
S
Chowdhury
Abhijit
A
Chowdhury
Sujit
S
Mukhopadhyay
Asish K
AK
Rajendran
K
K
Bhattacharya
S K
SK
Berg
Douglas E
DE
Nair
G Balakrish
GB
D000328:Adult; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D016022:Case-Control Studies; D004381:Duodenal Ulcer / Q000382:microbiology; D005260:Female; D005798:Genes, Bacterial; D005838:Genotype; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D007194:India; D008297:Male; D014774:Virulence / Q000235:genetics
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori; C063113:ice nucleation protein