Leukemia in donor cells after allogeneic hematopoietic stem cell transplant.
The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34(+) cells.
Brunstein
C G
CG
Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota, Minneapolis, MN 55455, USA.
Hirsch
B A
BA
Hammerschmidt
D
D
McGlennen
R C
RC
Nguyen
P L
PL
Verfaillie
C M
CM
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D018598:Minisatellite Repeats; D009190:Myelodysplastic Syndromes / Q000473:pathology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D014019:Tissue Donors; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous