The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.
Ishida
Tatsuhiro
T
Department of Pharmacokinetics and Biopharmaceutics, The University of Tokushima, Tokushima 770-8505, Japan. ishida@ph.tokushima-u.ac.jp
Maeda
Ryuhei
R
Ichihara
Masako
M
Mukai
Yasuko
Y
Motoki
Yoko
Y
Manabe
Yoshie
Y
Irimura
Kenji
K
Kiwada
Hiroshi
H
D000818:Animals; D004337:Drug Carriers; D006801:Humans; D007275:Injections, Intravenous; D008081:Liposomes; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D023421:Models, Animal; D011092:Polyethylene Glycols / Q000493:pharmacokinetics*; D051381:Rats; D013154:Spleen / Q000378:metabolism
D004337:Drug Carriers; D008081:Liposomes; D011092:Polyethylene Glycols