Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows.
Alteration of the polyunsaturated fatty acid (PUFA) composition of milk by dietary supplementation of cows may be beneficial to human health. However, dietary PUFAs may influence synthesis of both prostaglandins and steroid hormones. This study examined the effects of dietary PUFAs on reproductive parameters in lactating cows. Cows were fed an isoenergetic control ration (n = 8) or a diet supplemented with LinPreme (n = 7) or SoyPreme (n = 8). These proprietary feeds are derived from linseed or soybeans and contain high concentrations of linolenic acid (LNA, n-3) or linoleic acid (LA, n-6) protected PUFA, respectively. Both PUFA-supplemented diets reduced plasma progesterone, particularly in the early luteal phase, and increased the number of medium-sized (5-10 mm in diameter) follicles. The diameter of the first dominant follicle, insulin-like growth factor I (IGF-I) concentrations at oestrus and cholesterol concentrations were all higher in cows fed a diet supplemented with LA (n-6) than in cows that did not receive this supplement. In cows fed a diet supplemented with LNA (n-3), there was an increase in oestradiol during the follicular phase. Diet had no effect on non-esterified fatty acid or insulin concentrations, or on the duration of the oestrous cycle. The plasma concentration of 13,14,dihydro-15 keto PGF(2alpha) after administration of 50 iu oxytocin was unaffected by diet on day 15 and day 16 of the oestrous cycle, but showed a greater response on day 17 in the LA (n-6) supplemented group. Therefore, the PUFA content of the diet can influence both ovarian and uterine function in cows. However, further studies using larger numbers of cows are required to test whether fertility is also affected by such diets.
Robinson
R S
RS
Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, UK.
Pushpakumara
P G A
PG
Cheng
Z
Z
Peters
A R
AR
Abayasekara
D R E
DR
Wathes
D C
DC
D000818:Animals; D002417:Cattle; D002784:Cholesterol / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000096:biosynthesis; D004958:Estradiol / Q000097:blood; D004971:Estrus; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007774:Lactation; D019787:Linoleic Acid / Q000494:pharmacology; D006080:Ovarian Follicle / Q000033:anatomy & histology; D010053:Ovary / Q000000981:diagnostic imaging / Q000378:metabolism*; D010121:Oxytocin; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography; D014599:Uterus / Q000378:metabolism*; D017962:alpha-Linolenic Acid / Q000494:pharmacology
D004042:Dietary Fats, Unsaturated; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D007328:Insulin; D017962:alpha-Linolenic Acid; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D011374:Progesterone; D004958:Estradiol; D010121:Oxytocin; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol; D019787:Linoleic Acid; D015237:Dinoprost