A differential diagnostic approach to the pharmacological treatment of cognitive, behavioral, and affective disorders after traumatic brain injury.
The choice of pharmacologic treatment for cognitive, behavioral, or affective disorders following TBI depends upon an accurate diagnosis of the underlying disorder responsible for the clinical picture presented. However there are a myriad of possible causes for each sign or symptom, and often several contributing factors. A differential diagnostic approach is presented that structures the search for etiology into several categories: preinjury diagnosis, neuropsychological disorders, sensorimotor disorder, medical disorders, adverse effects of medications, reactive mood and anxiety disorders, and sleep disorders.
Glenn
Mel B
MB
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, MA 02114, USA. mglenn@partners.org
D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003072:Cognition Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D019964:Mood Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011379:Prognosis; D011619:Psychotropic Drugs / Q000008:administration & dosage*; D016896:Treatment Outcome
D004364:Pharmaceutical Preparations; D011619:Psychotropic Drugs