Sequence-selective visual recognition of nonprotected dipeptides.
[structure: see text] A receptor 1 with phenolphthalein and two crown ethers in the molecule develops brilliant purple color in the presence of dipeptides with a specific amino acid-sequence containing a C-terminal lysine. This type of color development could be extended to the detection of oligopeptides of a specific sequence at the N-terminal such as scyliorhinin I and APP(770)(394-410).
Tsubaki
Kazunori
K
Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. tsubaki@fos.kuicr.kyoto-u.ac.jp
Kusumoto
Tomokazu
T
Hayashi
Noriyuki
N
Nuruzzaman
Mohammad
M
Fuji
Kaoru
K
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003116:Color; D004151:Dipeptides / Q000737:chemistry*; D004988:Ethers, Cyclic; D007091:Image Processing, Computer-Assisted; D007202:Indicators and Reagents; D009842:Oligopeptides / Q000737:chemistry*; D020113:Phenolphthalein / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D004151:Dipeptides; D004988:Ethers, Cyclic; D007202:Indicators and Reagents; D009842:Oligopeptides; D011506:Proteins; D020113:Phenolphthalein