title: Validity of the depressive dimension extracted from principal component analysis of the PANSS in drug-free patients with schizophrenia.
abstract: Depressive symptoms frequently occur during the course of schizophrenia. This study explored the relationships between the schizophrenia symptomatology and three measures of depression. Eighty-one drug-free inpatients with acute schizophrenia were assessed with the positive and negative syndrome scale (PANSS), the Calgary depression scale for schizophrenia (CDSS), and the Hamilton rating scale for depression (HAM-D). The depressive subscale of PANSS (PANSS-D) was also considered as a third scale for measuring depression. A principal component analysis (PCA) of PANSS items identified five clinical dimensions of schizophrenia called 'negative', 'positive', 'anxio-depressive', 'excitement', and 'disorganisation and others'. Our anxio-depressive dimension (PANSS-ad) was strictly identical with the PANSS-D. Scores on CDSS and HAM-D were highly inter-correlated and highly correlated with the PANSS-ad. Furthermore, while scores on CDSS were correlated only with this dimension, scores at HAM-D were also positively correlated with the negative dimension and negatively correlated with the excitement dimension. In conclusion, our results suggest that PANSS evaluation itself may be sufficient to give a correct approximation of the depression in patients with schizophrenia. However, depression scales are of course needed to assess specifically depressive symptoms in patients with schizophrenia; hence, the CDSS could be a more specific instrument than HAM-D.
authors.affiliation: Centre Psychiatrique Universitaire Ibn Rochd, rue Tarik Ibn Ziad, Casablanca, Morocco.
authors.forename: Meriem
authors.initials: M
authors.lastname: El Yazaji
authors.forename: Omar
authors.initials: O
authors.lastname: Battas
authors.forename: Mohamed
authors.initials: M
authors.lastname: Agoub
authors.forename: Driss
authors.initials: D
authors.lastname: Moussaoui
authors.forename: Christel
authors.initials: C
authors.lastname: Gutknecht
authors.forename: Jean
authors.initials: J
authors.lastname: Dalery
authors.forename: Thierry
authors.initials: T
authors.lastname: d'Amato
authors.forename: Mohamed
authors.initials: M
authors.lastname: Saoud
mesh_terms: D000208:Acute Disease; D000328:Adult; D003863:Depression / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D010343:Patient Admission; D025341:Principal Component Analysis; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis*; D012565:Schizophrenic Psychology