title: Wavelet decomposition of cardiovascular signals for baroreceptor function tests in pigs.
abstract: In this paper, the discrete wavelet transform (DWT) was applied to analyze the fluctuations in RR interval and systolic arterial pressure (SAP) recorded from eight alpha-chloralose anesthetized pigs. Our aim was to characterize the autonomic modulation before and after cardiac autonomic blockade and during baroreflex function tests. The instantaneous power of decomposed low-frequency (LF) and high-frequency (HF) components was used for a time-variant spectral analysis. Our results suggested that transient events and changes in autonomic modulation were detected with high temporal resolution. A nonlinear relationship between RR interval and SAP during pharmacologically induced changes in blood pressure was found, when the superimposed effect of respiratory sinus arrhythmia was removed. In addition, the baroslopes were nearly linear when both the LF and HF components were removed using DWT decomposition.
authors.affiliation: Department of Biomedical Engineering and Informatics, University Hospital, Umeå, Sweden. Urban.Wiklund@vll.se
authors.forename: Urban
authors.initials: U
authors.lastname: Wiklund
authors.forename: Metin
authors.initials: M
authors.lastname: Akay
authors.forename: Stuart
authors.initials: S
authors.lastname: Morrison
authors.forename: Urban
authors.initials: U
authors.lastname: Niklasson
mesh_terms: D000465:Algorithms; D000768:Anesthesia, General; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002698:Chloralose / Q000494:pharmacology; D004562:Electrocardiography / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008955:Models, Cardiovascular; D009599:Nitroprusside / Q000494:pharmacology; D017711:Nonlinear Dynamics; D010656:Phenylephrine / Q000494:pharmacology; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013552:Swine
chemical_list: D009599:Nitroprusside; D010656:Phenylephrine; D002698:Chloralose