[Effect of glycyrrhizin on plasma endothelin and serum nitric oxide in myocardial ischemia reperfusion rabbits].
Effects of glycyrrhizin on plasma endothelin(ET), serum nitric oxide(NO) and creatine phosphokinase(CPK) activity of myocardial tissues were observed in myocardial ischemia/reperfusion rabbits. The results indicated that the CPK activity and plasma ET level increased and serum NO level decreased significantly after myocardial ischemia/reperfusion. In comparing with control, glycyrrhizin not only reduced significantly the increased plasma ET level and CPK activity of myocardial tissues, but also increased markedly the producing and releasing of NO(P < 0.01). All these facts suggest that glycyrrhizin exerts obviously protective effects on myocardial injury induced by ischemia/reperfusion.
Li
Y
Y
Department of Anesthesiology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Cai
H
H
D000818:Animals; D016232:Endothelins / Q000097:blood*; D005260:Female; D019695:Glycyrrhizic Acid / Q000494:pharmacology*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D011817:Rabbits
D016232:Endothelins; D009569:Nitric Oxide; D019695:Glycyrrhizic Acid