title: The effect of ethanol on acrylic bone cement.
abstract: Prosthesis loosening is a major problem associated with the use of poly(methyl methacrylate) (PMMA) bone cement that may be related to a peri-implant vacuolisation commonly observed at bone-cement interface. Methyl methacrylate (MMA) monomer may be one of the cement components partly responsible for the mentioned vacuolisation due to a cytotoxic effect associated to this compound. Alcoholism has been related to bone necrosis in predisposed individuals. Furthermore, ethanol has been shown to clean material with adherent cement debris during cleaning procedure in laboratory. Consequently, we have decided to study whether ethanol will also be related to an increased liberation of MMA from the polymer matrix. 'In vitro' release studies using PMMA plates were conducted to access the role of ethanol on the liberation of the monomer. Contact angle measurements and surface tension estimation were also carried out in order to find a possible effect of ethanol on surface cement properties. Results suggest that ethanol, even in small quantities, enhances the leaching of the monomer from the polymer matrix, but does not considerably change the wettability properties of the cement surface.
authors.affiliation: Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal. asimao@ff.ul.pt
authors.forename: A
authors.initials: A
authors.lastname: Bettencourt
authors.forename: A
authors.initials: A
authors.lastname: Calado
authors.forename: J
authors.initials: J
authors.lastname: Amaral
authors.forename: F M
authors.initials: FM
authors.lastname: Vale
authors.forename: J M T
authors.initials: JM
authors.lastname: Rico
authors.forename: J
authors.initials: J
authors.lastname: Monteiro
authors.forename: M F
authors.initials: MF
authors.lastname: Montemor
authors.forename: M G S
authors.initials: MG
authors.lastname: Ferreira
authors.forename: M
authors.initials: M
authors.lastname: Castro
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000465:Algorithms; D001843:Bone Cements / Q000737:chemistry*; D002021:Buffers; D000431:Ethanol / Q000737:chemistry*; D006207:Half-Life; D008962:Models, Theoretical; D010710:Phosphates / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry; D012995:Solubility; D012997:Solvents; D013500:Surface Tension; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D001843:Bone Cements; D002021:Buffers; D010710:Phosphates; D012997:Solvents; D000431:Ethanol; D019904:Polymethyl Methacrylate