A direct comparison of the antigen-specific antibody profiles of intravenous immunoglobulins derived from US and UK donor plasma.
OBJECTIVE
Intravenous immunoglobulin (IVIG) is used in a range of immunodeficiency states that require a broad spectrum of protective antibodies to a range of common pathogens. A comparison of the antigen-specific antibody profile of preparations of an IVIG (Vigam) derived from US and UK sourced plasma was performed, and these preparations were also compared with three other IVIG products from different manufacturers.


METHODS
Antibodies against a range of bacterial and viral pathogens were measured by immunoassay.


RESULTS
Similar profiles were found for Vigam made from UK and US source plasma and also for the other three IVIGs tested, but some specific differences were observed.


CONCLUSIONS
IVIG preparations have a similar therapeutic spectrum of antibodies when prepared from plasma sourced either from the UK or the US.
Matejtschuk
P
P
Bio Products Laboratory, Elstree, Herts., UK.
Chidwick
K
K
Prince
A
A
More
J E
JE
Goldblatt
D
D
D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D000918:Antibody Specificity; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000032:analysis; D016756:Immunoglobulins, Intravenous / Q000032:analysis* / Q000276:immunology; D017186:Titrimetry; D006113:United Kingdom; D014481:United States
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007132:Immunoglobulin Isotypes; D016756:Immunoglobulins, Intravenous