Life-threatening hyperkalemia: a complication of spironolactone for heart failure in a patient with renal insufficiency.
Serum potassium concentration should be measured immediately before operation to detect hyperkalemia in heart failure patients treated with spironolactone. Renal insufficiency, advanced age, potassium supplementation, decompensated congestive heart failure, and a spironolactone dose larger than 25 mg/d increase the risk of hyperkalemia as a consequence of spironolactone therapy.
Hu
Yuwen
Y
Department of Anesthesiology, Division of Cardiothoracic and Vascular Anesthesia, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
Carpenter
Jeffrey P
JP
Cheung
Albert T
AT
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D001784:Blood Gas Analysis; D006333:Heart Failure / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006947:Hyperkalemia / Q000097:blood / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000097:blood / Q000209:etiology; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications*; D013148:Spironolactone / Q000009:adverse effects* / Q000627:therapeutic use
D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D011188:Potassium