Success of intrauterine insemination in women aged 40-42 years.
OBJECTIVE
To determine how advancing female age decreases successful outcomes of intrauterine insemination (IUI) alone or combined with ovarian stimulation.


METHODS
Retrospective review.


METHODS
Academic fertility center.


METHODS
Infertile men and women.


METHODS
Intrauterine insemination alone or combined with ovarian stimulation.


METHODS
Pregnancy rates, miscarriage rates, and live birth rates per insemination cycle according to female age.


RESULTS
The 1,117 cycles of IUI resulted in 217 pregnancies, for an overall pregnancy rate for all female ages of 19.4% and a live birth rate of 12.9% per cycle inseminated. The overall live birth rate per insemination declined with advancing maternal age.


CONCLUSIONS
Advancing female age decreases successful outcomes with IUI. The live birth rate with IUI for women 40-42 years old (n = 82) was 9.8% per insemination and may demonstrate that IUI is an appropriate treatment for this age group of women.
Haebe
Jeffrey
J
Fertility Centre, Civic Hospital-Parkdale Clinic, The University of Ottawa, Ontario, Ottawa, Canada. jjhaebe@ottawahospital.on.ca
Martin
James
J
Tekepety
Francis
F
Tummon
Ian
I
Shepherd
Karen
K
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000502:physiology; D001723:Birth Rate; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D015994:Incidence; D007317:Insemination, Artificial, Homologous; D008297:Male; D008597:Menstrual Cycle / Q000097:blood; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013076:Sperm Count; D013081:Sperm Motility; D016896:Treatment Outcome
D005640:Follicle Stimulating Hormone