title: Neuritogenesis of herbal (+)- and (-)-syringaresinols separated by chiral HPLC in PC12h and Neuro2a cells.
abstract: Syringaresinol isolated from Epimedium koreanum NAKA1 and Magnolia officinalis REHD. et WILS. was subjected to optical resolution by chiral HPLC to give (+)- and (-)-enantiomers. The two syringaresinol enantiomers, as well as a mixture of their glucosides, showed dose-dependent neuritogenesis in a concentration range from 0.24 to 24 microM in PC12h cells.
authors.affiliation: Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Ishikawa, Japan. k-chiba@hokuriku-u.ac.jp
authors.forename: Kenzo
authors.initials: K
authors.lastname: Chiba
authors.forename: Matsumi
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Emiko
authors.initials: E
authors.lastname: Umegaki
authors.forename: Ming Run
authors.initials: MR
authors.lastname: Li
authors.forename: Zhen Wen
authors.initials: ZW
authors.lastname: Xu
authors.forename: Sumio
authors.initials: S
authors.lastname: Terada
authors.forename: Michihiro
authors.initials: M
authors.lastname: Taka
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Naoi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Mohri
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D034181:Epimedium / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry*; D009416:Nerve Regeneration / Q000187:drug effects*; D016501:Neurites / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D005663:Furans; D017705:Lignans; C042192:syringaresinol