[Relationship of nitric oxide and immunal function of the patients with acute hepatitis and hepatic cirrhosis].
The interleukin-12(IL-12), interleukin-10(IL-10), tumor necrosis factor(TNF) and nitric oxide (NO) levels in serum of 90 patients with hepatitis and cirrhosis were measured by the method of ELISA and colorimeter. The levels of IL-12, IL-10 and NO in serum of the patients with hepatitis were in close proximity to the level of healthy control, but the TNF level was significantly higher than that of healthy control. The IL-12, IL-10, TNF and NO levels in serum of the patients of hepatic cirrhosis were significantly higher than that of healthy control and patients with hepatitis. The results suggested that the NO level was not related with the hepatic damage of acute hepatitis. The dysfunction of immunology in the patients with cirrhosis was related with the increase of NO level.
Zhou
F
F
Department of Gastroenterology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Lu
F
F
Wu
H
H
Lin
Q
Q
Lin
L
L
D000328:Adult; D000368:Aged; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12; D009569:Nitric Oxide