Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?
The efficacy of a combination of ivermectin (IVM) and albendazole (ABZ) used as a chemoprophylactic treatment and as treatment of secondary hydatidosis is described for the first time. IVM treatment alone was not effective against Echinococcus granulosus, either when the protoscolices were recently inoculated or when they had developed to the metacestode stage. However, the efficacy of IVM and ABZ when used in combination as a prophylactic treatment was 95.72% and 87% with respect to the number and the wet weight of cysts, respectively. These results were higher than in the treatment of secondary hydatidosis, which were 44.8% and 45.26%, respectively. The ultrastructural changes in the germinal layer of the cysts after the treatments are also described.
Moreno
M J
MJ
Parasitology Laboratory, Faculty of Pharmacy, Universidad de Alcalá, Ctra. Madrid-Barcelona, Km 33,600, 28871 Alcalá de Henares, Madrid, Spain.
Casado
N
N
Urrea-París
M A
MA
Rodríguez-Caabeiro
F
F
D015766:Albendazole / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000923:Anticestodal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003560:Cysts / Q000469:parasitology / Q000648:ultrastructure; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004443:Echinococcosis / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D004446:Echinococcus / Q000033:anatomy & histology / Q000254:growth & development / Q000648:ultrastructure; D007559:Ivermectin / Q000494:pharmacology / Q000627:therapeutic use*; D008018:Life Cycle Stages; D051379:Mice
D000923:Anticestodal Agents; D007559:Ivermectin; D015766:Albendazole