title: Determination of urinary calcium-oxalate formation risk with BONN-Risk-Index and EQUIL applied to a family.
abstract: Apart from environmental and acquired risk factors, a person's genetic predisposition may have a distinct influence on the probability of the onset of urolithiasis. To investigate the family related development of calcium oxalate, CaOx, crystallization risk, we studied urines from three generations of the same family. The paternal line has been suffering from CaOx-urolithiasis for at least two generations; no case of urolithiasis has been reported from the maternal line and the youngest generation.We applied the BONN-Risk-Index and the computer program EQUIL to determine the crystallization risk of each family member (n = 7). We clearly verified by probability calculations of the existence of the two risk groups within the family and showed that one of the siblings of the youngest generation may have inherited the stone-formation risk from its paternal relatives as this person clearly reflects a high risk pattern.
authors.affiliation: Division of Experimental Urology, Department of Urology, Bonn University, Germany. norbert.laube@ukb.uni-bonn.de
authors.forename: Norbert
authors.initials: N
authors.lastname: Laube
authors.forename: Vera
authors.initials: V
authors.lastname: Labedzke
authors.forename: Stefan
authors.initials: S
authors.lastname: Hergarten
authors.forename: Albrecht
authors.initials: A
authors.lastname: Hesse
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002129:Calcium Oxalate / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D014545:Urinary Calculi / Q000652:urine
chemical_list: D002129:Calcium Oxalate