title: No one is naive: the significance of heterologous T-cell immunity.
abstract: Memory T cells that are specific for one virus can become activated during infection with an unrelated heterologous virus, and might have roles in protective immunity and immunopathology. The course of each infection is influenced by the T-cell memory pool that has been laid down by a host's history of previous infections, and with each successive infection, T-cell memory to previously encountered agents is modified. Here, we discuss evidence from studies in mice and humans that shows the importance of this phenomenon in determining the outcome of infection.
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA.
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Welsh
authors.forename: Liisa K
authors.initials: LK
authors.lastname: Selin
mesh_terms: D000273:Adipose Tissue / Q000276:immunology; D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D008168:Lung / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology
chemical_list: D011948:Receptors, Antigen, T-Cell