Identification of impurities and statistical classification of methamphetamine tablets (Ya-Ba) seized in Thailand.
Impurity profiles of methamphetamine tablets seized in Thailand have been investigated. The samples are extracted with small amounts of ethyl acetate under alkaline condition and the extracts are analyzed by capillary gas chromatography. Nine compounds (1,2-dimethyl-3-phenylaziridine, ephedrine, methylephedrine, N-formylmethamphetamine, N-acetylmethamphetamine, N-formylephedrine, N-acetylephedrine, N,O-diacetylephedrie, methamphetamine dimer) are identified as impurities in methamphetamine tablet. Caffeine and ethyl vanillin are also detected as diluents and/or adulterants, and acetylcodeine monoacetylmorphine and diacetylmorphine are contained in many samples. In addition, trans-3,4-dimethyl-5-phenyl-2-oxazolidone is newly found as an impurity. For characterization and comparison of methamphetamine tablet exhibits, intensely and commonly detectable nine peaks are selected as the factor for multivariate analysis. The procedures reported here permit classification of 250 analyzed exhibits into five groups and characterization of classified groups.
Puthaviriyakorn
Vichet
V
Office of the Narcotics Control Board, Scientific Narcotics Detection Division, 5 Din-Deang, Bangkok 10400, Thailand.
Siriviriyasomboon
Narinee
N
Phorachata
Juthamard
J
Pan-ox
Wiphada
W
Sasaki
Tetsuro
T
Tanaka
Ken
K
D000697:Central Nervous System Stimulants / Q000032:analysis*; D002849:Chromatography, Gas; D016000:Cluster Analysis; D004340:Drug Contamination; D008694:Methamphetamine / Q000032:analysis*; D013785:Thailand
D000697:Central Nervous System Stimulants; D008694:Methamphetamine