title: Measuring principles of frictional coefficients in cartilaginous tissues and its substitutes.
abstract: The frictional properties of cartilaginous tissues, such as the hydraulic permeability, the electro-osmotic permeability, the diffusion coefficients of various ions and solutes, and the electrical conductance, are vital data to characterise the extracellular environment in which chondrocytes reside. This paper analyses one-dimensional measurement principles of these coefficients. Particular attention is given to the deformation dependence of them and the highly deformable nature of the tissues. A suggested strategy is the combination of a diffusion experiment using radiotracer methods, an electro-osmotic flow experiment and an electro-osmotic pressure experiment at low electric current.
authors.affiliation: Department of Biomedical Engineering, Engineering Mechanics Institute, Eindhoven University of Technology, Eindhoven, The Netherlands. jacques@wfw.wtb.tue.nl
authors.forename: J M
authors.initials: JM
authors.lastname: Huyghe
authors.forename: C F
authors.initials: CF
authors.lastname: Janssen
authors.forename: C C
authors.initials: CC
authors.lastname: Van Donkelaar
authors.forename: Y
authors.initials: Y
authors.lastname: Lanir
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000502:physiology*; D004058:Diffusion; D004594:Electrophysiology; D017276:Friction; D009995:Osmosis; D012212:Rheology; D023822:Tissue Engineering