From castration-induced apoptosis of prostatic epithelium to the use of apoptotic genes in the treatment of prostate cancer.
Current knowledge of the mechanisms regulating androgen-ablation-induced apoptosis is reviewed, and our efforts to develop a system in which genes of the apoptotic pathway are used to induce therapeutic apoptosis in experimental models of prostate cancer are described.
Zhang
Ye
Y
Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine and VA Medical Center, Houston, Texas 77030, USA.
Nan
Bicheng
B
Yu
Jiang
J
Snabboon
Tithi
T
Andriani
Francesca
F
Marcelli
Marco
M
D000728:Androgens / Q000172:deficiency / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002369:Castration / Q000009:adverse effects*; D004847:Epithelial Cells / Q000473:pathology; D005544:Forecasting; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000502:physiology; D023421:Models, Animal; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2; D051381:Rats; D011944:Receptors, Androgen / Q000502:physiology; D051028:bcl-2-Associated X Protein
D000728:Androgens; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011944:Receptors, Androgen; D051028:bcl-2-Associated X Protein