title: Donor scoring system for cadaveric renal transplantation.
abstract: We studied early renal function in 241 consecutive patients who received cadaveric renal transplants at two different transplantation centers (group 1, n = 90; group 2, n = 151). Univariate and multivariate analyses of data from group 1 showed a significant correlation between seven donor variables and early renal function after cadaveric renal transplantation. A scoring system was developed from these seven donor variables (cause of death, 0-6 points; history of hypertension, 0-6; final creatinine clearance before procurement, 0-6; age, 0-6; history of diabetes mellitus, 0-3; cold ischemia time, 0-3; and severity of renal artery plaque, 0-3). Data from group 2 were used to validate the donor scoring system and stratify cadaver kidneys on the basis of score: grade A, 0-5 points; grade B, 6-10; grade C, 11-15; and grade D, 16-32. A significant decline in early renal function was observed with increasing donor score and grade of cadaver kidney. In conclusion, a donor scoring system based on information available at the time of procurement can be used to estimate early graft function after cadaveric renal transplantation and may assist in the allocation of marginal organs.
authors.affiliation: Division of Transplantation Surgery, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Nyberg
authors.forename: A J
authors.initials: AJ
authors.lastname: Matas
authors.forename: M
authors.initials: M
authors.lastname: Rogers
authors.forename: W S
authors.initials: WS
authors.lastname: Harmsen
authors.forename: J A
authors.initials: JA
authors.lastname: Velosa
authors.forename: T S
authors.initials: TS
authors.lastname: Larson
authors.forename: M
authors.initials: M
authors.lastname: Prieto
authors.forename: M B
authors.initials: MB
authors.lastname: Ishitani
authors.forename: S
authors.initials: S
authors.lastname: Sterioff
authors.forename: M D
authors.initials: MD
authors.lastname: Stegall
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002102:Cadaver; D002423:Cause of Death; D002648:Child; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018579:Patient Selection; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*
chemical_list: D003404:Creatinine