title: Solid-phase synthesis of n,n-disubstituted s,n'-diarylisothioureas: facile exchange reactions of isocyanates.
abstract: Reactions of resin-bound 1,1-disubstituted-2-arylisothioureas 4aa',ab'-ec' with aryl isocyanates, diversely substituted at the para and/or meta positions, and with o-fluoro- and 2,4-difluorophenyl isocyanate followed by appropriate cleavage led to the formation of N,N-disubstituted S,N'-diarylisothioureas 9[1-70] in good yields and high purities.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vvedensky
authors.forename: Boris V
authors.initials: BV
authors.lastname: Rogovoy
authors.forename: Katherine
authors.initials: K
authors.lastname: Kovalenko
authors.forename: Eduardo
authors.initials: E
authors.lastname: Torres
authors.forename: Behrouz
authors.initials: B
authors.lastname: Forood