title: Incorporation of cyclosporin A in solid lipid nanoparticles (SLN).
abstract: The cyclic undecapeptide cyclosporin A (CyA) a potent immunosuppressive drug used in many therapies, is extremely hydrophobic. Commercial products employ solubilising agents to improve gastrointestinal absorption. In the present study CyA solid lipid nanoparticles (SLN) are prepared from warm o/w microemulsion, dispersed in cold water. The matrix chiefly consists of stearic acid, phosphatidylcholine and taurocholate; up to 13% of CyA can be incorporated. The average diameter of CyA-loaded SLNs is below 300 nm and transmission electron microscopy (TEM) analysis shows them to be spherical. In vitro release of CyA from SLNs is low. CyA-loaded SLNs can be proposed for most administration routes, in particular for the duodenal route.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Turin, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Ugazio
authors.forename: Roberta
authors.initials: R
authors.lastname: Cavalli
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Gasco
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003102:Colloids; D016572:Cyclosporine / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D003102:Colloids; D007166:Immunosuppressive Agents; D016572:Cyclosporine