Utility of MIB-1 in evaluating cauterized cervical cone biopsy margins.
Interpretation of cervical cone biopsy margins removed by loop electrosurgical excision procedure is often problematic as a result of cautery artifacts. In this study, MIB-1 expression in cauterized tissues was almost identical to that in the adjacent noncauterized epithelium (correlation coefficients 0.97-0.98). Cauterized dysplastic/condylomatous epithelium showed significantly greater expression of MIB-1 than cauterized normal epithelium (p < or = 0.004) at all levels of the epithelium. Cut-off points for distinguishing dysplastic/condylomatous epithelium from normal epithelium were >15%, 30%, 5%, and 1% of cells in the basal, basal one-third, middle one-third, and surface one-third of epithelium, respectively.
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New York University Medical Center and Kaplan Cancer Center, New York 10016, USA.
D034961:Antigens, Nuclear; D016477:Artifacts; D015415:Biomarkers / Q000032:analysis*; D001706:Biopsy; D002425:Cautery; D002584:Cervix Uteri / Q000737:chemistry / Q000473:pathology*; D003218:Condylomata Acuminata / Q000473:pathology; D003937:Diagnosis, Differential; D004848:Epithelium / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D009687:Nuclear Proteins / Q000032:analysis*; D002577:Uterine Cervical Diseases / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000473:pathology
D034961:Antigens, Nuclear; D015415:Biomarkers; D019394:Ki-67 Antigen; D009687:Nuclear Proteins