Serotonin agents in the treatment of acquired brain injury.
BACKGROUND
The development of novel serotonin agents has led to an increased use of these medications throughout medical practice. An understanding of the basic pharmacological function of these agents is key to understanding their usefulness. Among persons with brain injury, serotonin agents have been used for the treatment of depression, panic disorder, obsessive-compulsive disorders, agitation, sleep disorders, and motor dysfunction.


CONCLUSIONS
This article will review the mechanisms, efficacy, and side effects of serotonin agents with a focus on persons with brain injury.
Zafonte
Ross D
RD
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA. zafonterd@msx.upmc.edu
Cullen
Nora
N
Lexell
Jan
J
D001930:Brain Injuries / Q000175:diagnosis* / Q000188:drug therapy*; D015283:Citalopram / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D016666:Fluvoxamine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use; D016896:Treatment Outcome
D015283:Citalopram; D005473:Fluoxetine; D016666:Fluvoxamine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline