Profound sinus bradycardia after intravenous nicardipine.
Nicardipine-induced bradycardia has been reported in experimental animals but not in clinical patients. We report a clinical case of unexpected bradycardia caused by nicardipine. The mechanism of this bradycardia was not clear, and depression of sympathetic tone by epidural anesthesia, hypothermia, and paroxysmal atrial fibrillation might have been contributory.
Arima
Hajime
H
Department of Anesthesia, Okazaki City Hospital, 3-1 Goshoai Koryuji-cho, Okazaki 444-8553, Japan. arima@sb.starcat.ne.jp
Sobue
Kazuya
K
Tanaka
Sayuki
S
Morishima
Tetsuro
T
Ando
Hiroshi
H
Katsuya
Hirotada
H
D000368:Aged; D001146:Arrhythmia, Sinus / Q000139:chemically induced* / Q000503:physiopathology; D001919:Bradycardia / Q000139:chemically induced* / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D004562:Electrocardiography; D004938:Esophageal Neoplasms / Q000601:surgery; D016629:Esophagectomy; D006801:Humans; D008297:Male; D009529:Nicardipine / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000503:physiopathology
D002121:Calcium Channel Blockers; D009529:Nicardipine