New derivatives of m-nitrobenzoyl-asparagic acid and m-nitrobenzoyl-asparagine with anti-inflammatory action.
In order to obtain new biologically active compounds some derivatives of 1-[N-(m-nitrobenzoyl)-alpha-D,L-asparaginyl]-2-benzyl-benzimidazole have been synthesized by ring opening reactions of 2-(m-nitrophenyl)-4-(beta-amidomethyl)-delta 2-oxazolin-5-one and 2-(m-nitrophenyl)-4-(beta-carboxymethyl)-delta 2-oxazolin-5-one with 2-benzylbenzimidazole (dibazole).
Filimon
M
M
Help-Flux Pharmacy, Iaşi.
Năstasă
V
V
Pavelescu
M
M
Băsu
C
C
Sunel
V
V
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001562:Benzimidazoles; C004453:bendazole