[Investigation of mutations of BRCA1 and BRCA2 genes in 52 breast cancer patients].
The proportion of BRCA1/2 genes varies widely among populations. We investigated 52 cases of breast cancer: 24 cases of familial breast cancer, 22--early-onset (till 40 years) and 6--bilateral cancer. The frequency of carriers of mutations among familial cancer cases was 16%, among cases of disease till 40 years--9%. 538insC BRCA1 was the most common genetic mutation among hereditary cases of breast cancer.
Tereshchenko
I V
IV
Research Institute of Oncology, Research Center, Russian Academy of Medical Sciences, Siberian Branch, Tomsk, Russia.
Béshém
V M
VM
Slonimskaia
E M
EM
Ponder
B A
BA
Férokh
P D
PD
Velichko
S A
SA
Shagiakhmetova
R A
RA
D000328:Adult; D017668:Age of Onset; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D009154:Mutation; D010375:Pedigree