Maspin is a tumour suppressor that inhibits breast cancer tumour metastasis in vivo.
Maspin is a member of the serpin family of serine proteases and functions as a tumour suppressor. A study using a new syngeneic mouse model for breast cancer suggests that maspin can inhibit metastasis in vivo.
Streuli
Charles H
CH
School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000201:enzymology; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009130:Muscle, Smooth / Q000166:cytology / Q000201:enzymology; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D009368:Neoplasm Transplantation; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000502:physiology; D015843:Serpins / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D014185:Transplantation, Isogeneic
D009363:Neoplasm Proteins; D011506:Proteins; D011993:Recombinant Fusion Proteins; C085344:SERPIN-B5; D015843:Serpins