title: Drug eruptions: the value of oral rechallenge test and patch test.
abstract: All in-and out-patients, who came for drug eruption consultation at the Dermatology Clinic, Ramathibodi Hospital from December 1997 to November 1998 were included in this study. Medical histories and physical examinations were performed by one of the authors. In suspected cases, a skin biopsy was performed to confirm the diagnosis. Patch test and oral challenge test were performed in some patients who had maculopapular, fixed drug eruption and acute generalized exanthematous pustulosis, with informed consent. Among 80 patients, the most common cutaneous reaction was maculopapular rash. Antimicrobial, drugs were the most common causative agents. The patch test was positive in only one patient from 12 cases. The oral provocative test was positive in two patients from 4 cases. It is concluded that oral provocative test is still necessary to get a definite diagnosis of causative agent. The value of patch test needs further study.
authors.affiliation: Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Siripen
authors.initials: S
authors.lastname: Puavilai
authors.forename: Amornsri
authors.initials: A
authors.lastname: Chunharas
authors.forename: Somnuk
authors.initials: S
authors.lastname: Kamtavee
authors.forename: Sukanlaya
authors.initials: S
authors.lastname: Pongwiriyapanich
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D064907:Diagnostic Uses of Chemicals; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D004364:Pharmaceutical Preparations
chemical_list: D064907:Diagnostic Uses of Chemicals; D004364:Pharmaceutical Preparations