Structure and activity of glycosylphosphatidylinositol anchors of Plasmodium falciparum.
The glycosylphosphatidylinositol (GPI) anchors of Plasmodium falciparum are thought to be etiologic agents of malaria based on their ability to induce proinflammatory cytokine production by macrophages and cause symptoms that resemble severe malaria illness in animals. This review summarizes the published information on the structures of P. falciparum GPIs, structure-activity relationship, and anti-GPI antibodies in the host.
Channe Gowda
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Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA. gowda@psu.edu
D000818:Animals; D002240:Carbohydrate Sequence; D002448:Cell Adhesion; D016207:Cytokines / Q000276:immunology; D017261:Glycosylphosphatidylinositols / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D016778:Malaria, Falciparum / Q000469:parasitology; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000276:immunology* / Q000472:pathogenicity*; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D014774:Virulence
D016207:Cytokines; D017261:Glycosylphosphatidylinositols