title: Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit.
abstract: A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC50 of; 46.2 microM) exhibited more potency than Kojic acid (IC50; 77.4 microM) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.
authors.affiliation: Tohoku Pharmaceutical University, Sendai, Japan. kenrs@tohoku-pharm.ac.jp
authors.forename: Kenroh
authors.initials: K
authors.lastname: Sasaki
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D000363:Agaricales / Q000201:enzymology; D002957:Citrus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D047309:Flavones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000096:biosynthesis; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D011753:Pyrones / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004791:Enzyme Inhibitors; D047309:Flavones; D005419:Flavonoids; D008543:Melanins; D011753:Pyrones; C011890:kojic acid; C008661:nobiletin; D014442:Monophenol Monooxygenase