Uncoupling proteins, leptin, and obesity: an updated review.
The hypothesis that the novel uncoupling protein UCP3 is thermogenic and/or thermoregulatory is discussed. In vitro, ex vivo, and in vivo models are presented. The beta(3)-adrenoceptors are crucial for the appearance of UCP1-expressing cells in the white adipose tissue. These cells might differ from classical brown adipocytes. Besides its well-known effect on brown adipose tissue UCP1, leptin might stimulate indirectly muscle UCP3 expression.
Giacobino
Jean-Paul
JP
Département de Biochimie Médicale, C. M. U., 1211 Geneva 4, Switzerland. jean-paul.giacobino@medicine.unige.ch
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007473:Ion Channels; D020738:Leptin / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D024101:Mitochondrial Proteins; D009765:Obesity / Q000503:physiopathology*; D011485:Protein Binding; D022702:Receptors, Adrenergic, beta-3 / Q000502:physiology; D054411:Receptors, Leptin; D000071256:Uncoupling Protein 1; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D007473:Ion Channels; C515448:LEPR protein, human; D020738:Leptin; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D022702:Receptors, Adrenergic, beta-3; D054411:Receptors, Leptin; C000604371:UCP1 protein, human; C000604392:UCP3 protein, human; C000604372:Ucp1 protein, mouse; C000604393:Ucp3 protein, mouse; D000071256:Uncoupling Protein 1; D000071247:Uncoupling Protein 3; C515447:leptin receptor, mouse