Simulation of cardiovascular physiology: the diastolic function(s) of the heart.
The cardiovascular system was simulated by using an equivalent electronic circuit. Four sets of simulations were performed. The basic variables investigated were cardiac output and stroke volume. They were studied as functions (i) of right ventricular capacitance and negative intrathoracic pressure; (ii) of left ventricular relaxation and of heart rate; and (iii) of left ventricle failure. It seems that a satisfactory simulation of systolic and diastolic functions of the heart is possible. Presented simulations improve our understanding of the role of the capacitance of both ventricles and of the diastolic relaxation in cardiovascular physiology.
Podnar
T
T
University Hospital of Pediatrics, Faculty of Medicine, University of Ljubljana, 1104 Ljubljana, Slovenia.
Runovc
F
F
Kordas
M
M
D002302:Cardiac Output / Q000502:physiology; D003198:Computer Simulation; D003971:Diastole / Q000502:physiology*; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology