title: Outcome following mitral valve replacement in patients with mitral stenosis and moderately reduced left ventricular ejection fraction.
abstract: BACKGROUND
  Some patients with mitral stenosis (MS) have moderately reduced left ventricular (LV) ejection fraction (EF), due to either depressed myocardial contractility or alterations in loading conditions. The effect of moderately reduced LV EF on outcome after mitral valve replacement (MVR) is not known.
  
  
  METHODS
  We studied 16 consecutive patients with LV EF < or = 0.50 and MS without significant mitral regurgitation or other valvular or coronary artery disease (Group I). We selected four controls with LV EF >0.50 for each patient, matched for time of surgery (Group II, n=64). Mean EF in Groups I and II was 0.45 and 0.66, respectively. We compared short- and long-term outcome between the two groups.
  
  
  RESULTS
  There were no perioperative deaths. Group I patients had a higher incidence of in-hospital postoperative heart failure (25% vs. 6%, P=0.02). Mean follow-up was 9 years in both groups. Mean New York Heart Association class improved from 2.4 to 1.7 in both groups. Group I patients had a higher incidence of heart failure deaths (13% vs. 2%, P=0.03) and admissions (40% vs. 13%, P=0.01). There were, however, no differences between Groups I and II in overall mortality (27% vs. 21%), rate of cardiac admissions (69% vs. 53%), or mean Specific Activity Scale Score (2.5 vs. 2.5).
  
  
  CONCLUSIONS
  Although patients with MS and moderately reduced LV EF are at higher risk for heart failure after MVR, overall mortality is not different from that of patients with normal EF. Moderate depression of LV EF should not be a contraindication to MVR for MS.
authors.affiliation: Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, MA 02114-3117, USA.
authors.forename: Arduino A
authors.initials: AA
authors.lastname: Mangoni
authors.forename: Todd M
authors.initials: TM
authors.lastname: Koelling
authors.forename: Gregg S
authors.initials: GS
authors.lastname: Meyer
authors.forename: Cary W
authors.initials: CW
authors.lastname: Akins
authors.forename: Michael A
authors.initials: MA
authors.lastname: Fifer
mesh_terms: D000368:Aged; D001705:Bioprosthesis; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008946:Mitral Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D011474:Prosthesis Design; D012189:Retrospective Studies; D013318:Stroke Volume; D016896:Treatment Outcome; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000601:surgery*