The first successful base-promoted isomerization of propargyl amides to chiral ynamides. Applications in ring-closing metathesis of ene-ynamides and tandem RCM of diene-ynamides.
[reaction: see text] A highly useful sequence of reactions is described here. These reactions consist of the first successful base-induced isomerizations of propargyl amides to chiral ynamides, applications of these novel ynamides in ring-closure metathesis leading to chiral 2-amidodienes useful for Diels-Alder cycloadditions, and the first successful tandem RCM of diene-ynamides.
Huang
Jian
J
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Xiong
Hui
H
Hsung
Richard P
RP
Rameshkumar
C
C
Mulder
Jason A
JA
Grebe
Tyler P
TP