title: Profound sinus bradycardia after intravenous nicardipine.
abstract: Nicardipine-induced bradycardia has been reported in experimental animals but not in clinical patients. We report a clinical case of unexpected bradycardia caused by nicardipine. The mechanism of this bradycardia was not clear, and depression of sympathetic tone by epidural anesthesia, hypothermia, and paroxysmal atrial fibrillation might have been contributory.
authors.affiliation: Department of Anesthesia, Okazaki City Hospital, 3-1 Goshoai Koryuji-cho, Okazaki 444-8553, Japan. arima@sb.starcat.ne.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Arima
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sobue
authors.forename: Sayuki
authors.initials: S
authors.lastname: Tanaka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Morishima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ando
authors.forename: Hirotada
authors.initials: H
authors.lastname: Katsuya
mesh_terms: D000368:Aged; D001146:Arrhythmia, Sinus / Q000139:chemically induced* / Q000503:physiopathology; D001919:Bradycardia / Q000139:chemically induced* / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D004562:Electrocardiography; D004938:Esophageal Neoplasms / Q000601:surgery; D016629:Esophagectomy; D006801:Humans; D008297:Male; D009529:Nicardipine / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D002121:Calcium Channel Blockers; D009529:Nicardipine