title: Parotideal lymph node metastasis in squamous cell carcinoma of the skin.
abstract: BACKGROUND
  Metastatic involvement of the parotideal lymph nodes from cutaneous squamous cell carcinoma is rare in occurrence, but has a high prognostic value. The aim of the present study was to define a patient group with a high risk for development of regional metastasis and to determine the follow-up course and therapy of metastasis in these patients.
  
  
  METHODS
  Nineteen patients treated with malignancies of the parotid gland over a time period of four years were analyzed prospectively.
  
  
  RESULTS
  In 6 out of 19 patients the parotideal tumor proved to be a lymph node metastasis of previously treated poorly differentiated squamous cell carcinoma of the skin. The diameter of the primary tumor was at least 1.5 cm in 5 out of 6 cases. The time interval between detection of metastatic involvement of the parotid gland and diagnosis of a preexisting skin cancer was approximately 7 months. Metastastic infiltration of cervical lymph nodes could be shown in 4 patients. In one patient pulmonary metastases were detected.
  
  
  CONCLUSIONS
  On the basis of data from the literature and the results presented here, patients who are at high risk for regional metastasis were defined. Clinical examination of the parotid gland and cervical lymph nodes should be performed frequently in these patients at least for 18 months after primary tumor diagnosis. Parotideal lymph node metastases of a squamous cell carcinoma of the head skin should have similar treatment to primary squamous cell carcinoma of the parotid gland provided that a curative option exists.
authors.affiliation: Department of Otorhinolaryngology, Philipps University, Deutschhausstrasse 3, 35037 Marburg, Germany. teymoort@mailer.uni-marburg.de
authors.forename: Afshin
authors.initials: A
authors.lastname: Teymoortash
authors.forename: A A
authors.initials: AA
authors.lastname: Dünne
authors.forename: J A
authors.initials: JA
authors.lastname: Werner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000556:secondary* / Q000601:surgery; D012307:Risk Factors; D012878:Skin Neoplasms / Q000473:pathology*; D016896:Treatment Outcome