title: Low expression of DNA polymerase beta in human testicular germ cell tumours--impact on foetal gonocytic origin theory.
abstract: Different models of pathogenesis of adult testicular germ cell tumours (TGCTs) are presented. Analysis of telomeric length and DNA polymerase beta expression suggests that seminoma and nonseminoma, two main histological types of TGCTs, derive independently from transformed foetal primordial cells.
authors.affiliation: Department of Molecular Biology, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland. radka@coi.waw.pl
authors.forename: Radosława
authors.initials: R
authors.lastname: Nowak
authors.forename: Ewa A
authors.initials: EA
authors.lastname: Grzybowska
authors.forename: Anna
authors.initials: A
authors.lastname: Wilczyńska
authors.forename: Roman
authors.initials: R
authors.lastname: Pykało
authors.forename: Janusz A
authors.initials: JA
authors.lastname: Siedlecki
mesh_terms: D015152:Blotting, Northern; D019951:DNA Polymerase beta / Q000378:metabolism*; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology*; D018237:Germinoma / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D013090:Spermatocytes / Q000201:enzymology / Q000473:pathology; D013091:Spermatogenesis; D016615:Telomere / Q000378:metabolism; D013736:Testicular Neoplasms / Q000201:enzymology* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016159:Tumor Suppressor Protein p53; D019951:DNA Polymerase beta