[Akathisia due to risperidone withdrawal: two clinical cases].
Akathisia due to withdrawal or disruption of antipsychotic treatment is a rare and scarcely elucidated presentation of extrapyramidalism which can also occur after other drug withdrawal. After having reviewed biomedical data basis IME and the latest seven years of MEDLINE and EMBASE, we only found one case, which was published in 1997, of persistent akathisia after risperidone withdrawal, but it had started under treatment with haloperidol. We next present the clinical observation of other two patients who developed akathisia after risperidone withdrawal. In one of them, akathisia started within the first days of treatment at hig-medium doses and got worse after withdrawal; in the other case, akathisia immediately started just after withdrawal of a nine-month treatment with risperidone at low doses.
Bertolín Guillén
J M
JM
Unidad de Psiquiatría, Hospital General Universitario, Valencia. jose.m.bertolin@uv.es
Martínez Franco
L
L
Juni Anahuja
J
J
D000328:Adult; D017109:Akathisia, Drug-Induced / Q000209:etiology*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D018967:Risperidone / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome
D014150:Antipsychotic Agents; D018967:Risperidone