[Influence factors in the clearance of urea and creatinine through gastrointestinal tract].
To investigate the affection of different osmotic density, pH value, and dialytic fluid with drugs on the clearance of urea and creatinine through gastrointestinal tract, we used the renal-artery-ligated rabbits as the model. After the intravenous administration of urea and creatinine through ear vein, fistulas in duodenum at about 5 cm to pylorus and in ileum at about 5 cm to the valva ileocecalis were made to carry out intestinal dialysis. The results showed that the clearance of the urea in treated groups with mannitol, regitine, and oxystarch was higher than that in the control group with normal saline solution(P < 0.05). The clearance of urea and creatinine in treated groups with atropine was higher than that in the control group(P < 0.05). There was no significant difference in the clearance of urea and creatinine among treated groups with different intestine pH value.
Huang
Z
Z
Department of Renal Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Jiang
Y
Y
Luo
J
J
D000818:Animals; D003404:Creatinine / Q000378:metabolism*; D003956:Dialysis / Q000379:methods*; D005260:Female; D006863:Hydrogen-Ion Concentration; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011817:Rabbits; D013213:Starch / Q000031:analogs & derivatives* / Q000494:pharmacology; D014508:Urea / Q000378:metabolism*
D008353:Mannitol; D014508:Urea; D013213:Starch; C012880:dialdehyde starch; D003404:Creatinine; D010646:Phentolamine