title: Transplantation for accidental acute high-dose total body neutron- and gamma-radiation exposure.
abstract: Accidental exposure to acute high-dose total body neutron radiation is rare. We report a 35-year-old man exposed to a total body dose of 5.4 Gy neutron- and 8.5-13 Gy gamma-radiation in a radiation criticality accident. He received a blood stem cell transplant from his HLA-identical sister. There was bone marrow recovery with complete donor chimerism. Random chromatid breaks were observed in donor cells suggesting a bystander effect of neutron exposure. The subject died 82 days after the accident (75 days post transplant) from multi-organ failure.
authors.affiliation: Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Kumano
authors.forename: S
authors.initials: S
authors.lastname: Seo
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Izutsu
authors.forename: K
authors.initials: K
authors.lastname: Yuji
authors.forename: S
authors.initials: S
authors.lastname: Masuda
authors.forename: S
authors.initials: S
authors.lastname: Futami
authors.forename: M
authors.initials: M
authors.lastname: Nishida
authors.forename: G
authors.initials: G
authors.lastname: Suzuki
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
authors.forename: M
authors.initials: M
authors.lastname: Fukayama
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
authors.forename: H
authors.initials: H
authors.lastname: Hirai
mesh_terms: D000328:Adult; D001853:Bone Marrow; D002842:Chromatids / Q000528:radiation effects; D005214:Fast Neutrons / Q000009:adverse effects*; D017809:Fatal Outcome; D005720:Gamma Rays / Q000009:adverse effects*; D006085:Graft Survival; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D011210:Power Plants; D011829:Radiation Dosage; D018788:Radioactive Hazard Release; D018183:Transplantation Chimera