Gastric hyperalgesia and changes in voltage gated sodium channel function in the rat.
Potential peripheral mechanisms that might contribute to the development of visceral hypersensitivity and ultimately to the altered sensations that characterise functional gastrointestinal disorders were examined by developing experimental models of gastric hyperalgesia. A direct link between alteration in behaviour and potential mechanisms of increased excitability of the gastric afferent innervation was found.
Gebhart
G F
GF
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA. gf-gebhart@uiowa.edu
Bielefeldt
K
K
Ozaki
N
N
D019342:Acetic Acid; D000818:Animals; D006930:Hyperalgesia / Q000503:physiopathology*; D007460:Iodoacetamide; D023421:Models, Animal; D051381:Rats; D012677:Sensation / Q000502:physiology*; D015222:Sodium Channels / Q000502:physiology*; D013270:Stomach / Q000503:physiopathology*; D017833:Visceral Afferents / Q000503:physiopathology*
D015222:Sodium Channels; D019342:Acetic Acid; D007460:Iodoacetamide