[Levels of lipid peroxidation products and activity of antiradical defense enzymes in blood of patients with Bechterew disease].
OBJECTIVE
To study lipid peroxidation (LPO) in Bechterev's disease (BD) treated with antiinflammatory and antioxidant drugs.


METHODS
LPO was estimated in 75 BD patients before medication and during this treatment. 30 healthy volunteers served control.


RESULTS
Levels of LPO products was high but activity of antioxidant defense enzymes low in BD patients.


CONCLUSIONS
Antiinflammatory drugs meloxicam, indometacin and an antioxidant drug triovit depressed LPO activity, improve the patients' condition and results of functional tests.
Mitrofanova
O V
OV
Bagirova
V V
VV
Krasikov
S I
SI
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use; D015227:Lipid Peroxidation; D008297:Male; D000077239:Meloxicam; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000188:drug therapy / Q000201:enzymology* / Q000378:metabolism*; D013843:Thiazines / Q000008:administration & dosage / Q000627:therapeutic use; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D005609:Free Radicals; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam; D007213:Indomethacin