[The early protective effects of basic fibroblast growth factor on acute spinal cord injury in rats].
OBJECTIVE
To study the early protective effects of basic fibroblast growth factor(bFGF) on the experimental acute spinal cord injury.


METHODS
Thirty-four SD rats were randomly divided into three groups, and were subjected to contusion of thoracolumbar spinal cord. A thin plastic tube was placed in subarachnoid space below the injury level for perfusion. The bFGF-treated rats were received 20 microliters bFGF(containing bFGF 100 U) at once, 30 min, 1, 2, 3, 4, 6, 12, 24 and 48 hours after injury, and an equal volume of normal saline was given to the control group at the same time. The injured spinal cord was detected by morphological observation and biochemical index after injury.


RESULTS
The degree of ionic disorder in bFGF-treated rats was significantly ameliorated and the contents of H2O were also markedly decreased. The morphological finding showed that the damages of gray and white matter in bFGF-treated rats were slighter than those of saline-treated rats.


CONCLUSIONS
bFGF has some protective effects on the secondary lesion of early spinal cord injury in rats.
Liu
W G
WG
Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical University, Wuhan, Hubei, P. R. China 430030.
Luo
Y X
YX
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology / Q000627:therapeutic use*; D008159:Lumbar Vertebrae; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D013904:Thoracic Vertebrae
D018696:Neuroprotective Agents; D016222:Fibroblast Growth Factor 2; D002118:Calcium