title: Treatment of severe infectious mononucleosis with famciclovir.
abstract: We report a patient with severe acute infectious mononucleosis who was successfully treated with famciclovir. A 15-year-old male was admitted with a 6-week history of fever, malaise, generalized lymphadenopathy, and hepatosplenomegaly, the patient was acutely ill with a temperature of 39.0 degrees C. Oropharingeal examination revealed enlarged tonsils partially obstructing the airways. EBV serology obtained during admission showed a positive Monospot test, virus capsid antigen IgM, 1:320, Epstein-Barr nuclear and early antigen, negative. After 72 hours of treatment with famciclovir (500 mg t.i.d.), the patient was afebrile with important regression of the lymphadenopathy, enlarged tonsils and hepatosplenomegaly. Because acute infectious mononucleosis may be associated with extensive and prolonged disease, the potential therapeutic role of famciclovir in the treatment of severe forms of the disease deserves further studies.
authors.affiliation: Infectious Diseases Unit, Hospital das Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, RS, Brazil. Lgoldani@vortex.UFRGS.br
authors.forename: Luciano Z
authors.initials: LZ
authors.lastname: Goldani
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D000077595:Famciclovir; D006801:Humans; D007244:Infectious Mononucleosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male
chemical_list: D000998:Antiviral Agents; D015075:2-Aminopurine; D000077595:Famciclovir