[The "air pouch" model in mice and a study of the wound fluid proteolytic activity].
The experimental model of a cutaneous wound in mice has been offered, aimed to study the proteolytic activity of the wound fluid produced at early stages of wound healing, and to examine the continuous inflammatory state. The presence of metalloproteinases MMP-2 and MMP-9 in the wound fluid matrix was found to correlate with the existence of neutrophils and macrophages in the tissue.
Voronkina
I V
IV
Institute of Cytology RAS, St. Petersburg. voron@link.cytspb.rssi.ru
Kharisov
A M
AM
Blinova
M I
MI
Potokin
I L
IL
Paramonov
B A
BA
Pinaev
G P
GP
D000818:Animals; D002351:Carrageenan; D003872:Dermatitis / Q000209:etiology / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D005122:Exudates and Transudates / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology; D020778:Matrix Metalloproteinase 2 / Q000032:analysis / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000032:analysis / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000293:injuries* / Q000378:metabolism; D014945:Wound Healing
D002351:Carrageenan; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9