title: [Genetic analysis of deltamethrin resistance in Culex pipiens pallens].
abstract: OBJECTIVE
  To analyse the genetic character of deltamethrin resistant laboratory strain (resistant factor being 518) of Cx. pipiens pallens.
  
  
  METHODS
  Genetic studies were made of deltamethrin-susceptible and-resistant strains of Cx. pipiens pallens with LC-P curve constructed from the response of fourth instar larvae to deltamethrin treatment, and the resistance mechanisms were analysed with synergetic tests in PB, DEF and TPP.
  
  
  RESULTS
  The resistant factors of F1 generation from cross and reciprocal cross are respectively 154.8 and 159.2; the LC-P curve of F1 generation gets near to that of resistant parents, D = 0.625; there exist no obvious platform in 50% mortality of BC generation and 25% and 75% mortality of F2 generation, and there are larger differences between the determining curve and theoretical curve in both BC and F2 generations, P < 0.01; the synergetic ratios of PB, DEF and TPP are 27.13, 1.22 and 1.05.
  
  
  CONCLUSIONS
  Deltamethrin resistance of Cx. pipiens pallens is controlled by two or more autosomal genes, and the main gene involved is incompletely dominant; multi-functional oxidase is mainly responsible for the resistance.
authors.affiliation: Department of Parasitology, Nanjing Medical University, Nanjing 210029.
authors.forename: C
authors.initials: C
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.forename: B
authors.initials: B
authors.lastname: Ye
mesh_terms: D000818:Animals; D003465:Culex / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics; D009570:Nitriles; D011722:Pyrethrins / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D006899:Mixed Function Oxygenases