title: Protocol for measuring the endurance capacity of mice in an adjustable-current swimming pool.
abstract: We re-examined the methods used in an adjustable-current swimming pool for evaluating the endurance capacity of mice to improve the sensitivity and reproducibility. We found that the BALB/c strain was most suitable to minimize the variation in time taken to swim to the point of fatigue. We found that precise adjustment of the apparatus and the use of three primary swimming trials to select mice before a study made the swimming time more uniform. This procedure was used to establish a more precise evaluation protocol.
authors.affiliation: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Mizunoya
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oyaizu
authors.forename: Kengo
authors.initials: K
authors.lastname: Ishihara
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D005082:Physical Exertion; D013045:Species Specificity; D013550:Swimming