title: Conserved function for embryonic nodal cilia.
abstract: How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.
authors.affiliation: Center for Children, Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112-5550, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Essner
authors.forename: Kyle J
authors.initials: KJ
authors.lastname: Vogan
authors.forename: Molly K
authors.initials: MK
authors.lastname: Wagner
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Tabin
authors.forename: H Joseph
authors.initials: HJ
authors.lastname: Yost
authors.forename: Martina
authors.initials: M
authors.lastname: Brueckner
mesh_terms: D000818:Animals; D056444:Axonemal Dyneins; D019521:Body Patterning; D002642:Chick Embryo; D002923:Cilia / Q000502:physiology*; D017124:Conserved Sequence; D004398:Dyneins / Q000235:genetics / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D004625:Embryo, Nonmammalian; D005775:Gastrula / Q000166:cytology / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D020897:Organizers, Embryonic / Q000196:embryology / Q000378:metabolism; D015398:Signal Transduction; D014714:Vertebrates / Q000196:embryology* / Q000235:genetics; D014981:Xenopus / Q000196:embryology / Q000235:genetics; D015027:Zebrafish / Q000196:embryology / Q000235:genetics; D029961:Zebrafish Proteins
chemical_list: C402391:Dnah11 protein, mouse; D029961:Zebrafish Proteins; C498538:dnah9 protein, zebrafish; D056444:Axonemal Dyneins; D004398:Dyneins