title: Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells.
abstract: Bryonia alba roots (BAR) are widely used as an adaptogenic and restorative drug with immunomodulatory and stress-protective properties that increase the non-specific resistance of an organism toward harmful stimuli. Potential genotoxic activity of aqueous and methanol extracts of BAR was studied on human normal (lymphocytes) and transformed (HeLa and Caco-2) cells using single cell gel electrophoresis (the comet assay). The results obtained did not show any evidence of genotoxic effects of BAR.
authors.affiliation: Laboratory of Carcinogenesis, Cancer Research Center, Yerevan, Armenia. genetik@ysu.am
authors.forename: A K
authors.initials: AK
authors.lastname: Nersesyan
authors.forename: A R
authors.initials: AR
authors.lastname: Collins
mesh_terms: D002470:Cell Survival / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004249:DNA Damage; D006367:HeLa Cells; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000633:toxicity*; D018517:Plant Roots; D027824:Rosaceae; D014407:Tumor Cells, Cultured
chemical_list: D009153:Mutagens; D010936:Plant Extracts