Solution-phase parallel synthesis of substituted benzimidazoles.
A solution-phase parallel synthesis of o-phenylenediamines is described. These intermediates were then subsequently converted to benzimidazole scaffolds (three-point diversity) in excellent purities and yields. High-throughput purification of this multistep synthetic sequence was accomplished using polymer-bound scavengers and reagents and liquid-liquid extraction protocols.
Raju
B
B
Department of Chemistry & Biophysics, Texas Biotechnology Corporation, 7000 Fannin, Suite 1920, Houston Texas 77030, USA.
Nguyen
Noel
N
Holland
George W
GW