Measuring principles of frictional coefficients in cartilaginous tissues and its substitutes.
The frictional properties of cartilaginous tissues, such as the hydraulic permeability, the electro-osmotic permeability, the diffusion coefficients of various ions and solutes, and the electrical conductance, are vital data to characterise the extracellular environment in which chondrocytes reside. This paper analyses one-dimensional measurement principles of these coefficients. Particular attention is given to the deformation dependence of them and the highly deformable nature of the tissues. A suggested strategy is the combination of a diffusion experiment using radiotracer methods, an electro-osmotic flow experiment and an electro-osmotic pressure experiment at low electric current.
Huyghe
J M
JM
Department of Biomedical Engineering, Engineering Mechanics Institute, Eindhoven University of Technology, Eindhoven, The Netherlands. jacques@wfw.wtb.tue.nl
Janssen
C F
CF
Van Donkelaar
C C
CC
Lanir
Y
Y
D000818:Animals; D002358:Cartilage, Articular / Q000502:physiology*; D004058:Diffusion; D004594:Electrophysiology; D017276:Friction; D009995:Osmosis; D012212:Rheology; D023822:Tissue Engineering