title: [In vitro sensitivity of Plasmodium falciparum to chloroquine, piperaquine, pyronaridine and artesunate in Yuxi prefecture of Yunnan province].
abstract: OBJECTIVE
  To assess the sensitivity of Plasmodium falciparum to four antimalarials.
  
  
  METHODS
  WHO standard in vitro microtest was used.
  
  
  RESULTS
  The resistance rates of the malaria parasite to chloroquine, piperaquine pyronaridine and artesunate were 85.7%, 66.7%, 38.1% and 5.0%, respectively.
  
  
  CONCLUSIONS
  Among the antimalarials tested in Yuxi Prefecture, Yunnan Province, high resistance of P. falciparum to chloroquine and piperaquine was found. The sensitivity of P. falciparum in part of the cases to pyronaridine decreased. However, most of the cases were relatively sensitive to artesunate.
authors.affiliation: Yuxi City Health and Antiepidemic Station, Yuxi 653100.
authors.forename: B
authors.initials: B
authors.lastname: Fan
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Wen
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D000077332:Artesunate; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D011804:Quinolines / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology; D010879:Piperazines
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate; D002738:Chloroquine; D009287:Naphthyridines; D011804:Quinolines; D012717:Sesquiterpenes; C034759:piperaquine; D010879:Piperazines; C027871:pyronaridine