Electrochemical behaviour of droxicam: kinetic study in aqueous-organic media.
A kinetic study of the hydrolytic decomposition of droxicam was carried out in order to establish the possible pharmacological action of the drug in the organism of the human being. The electrochemical technique used was scan cyclic voltammetry on a HMDE, giving a well-defined peak. Due to the insolubility of droxicam in water, the working media was a methanol-H(2)O (4:96, V/V) mixture. The decomposition product of droxicam is piroxicam, which is also reduced on a mercury electrode giving a well-defined cyclic voltammetric peak. It is proposed that the decomposition of droxicam is controlled by a kinetic equation: v=(1.93 x 10(-3)+78.9 [D]) [D]=k(D)[D].
Acuña
J A
JA
Department of Analytical Chemistry, Faculty of Sciences, University of Valladolid, C/Prado de la Magdalena s/n, 47005, Valladolid, Spain.
de la Fuente
C
C
Vázquez
M D
MD
Tascón
M L
ML
Gómez
M I
MI
Mata
F
F
Sánchez-Batanero
P
P
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D000432:Methanol / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011725:Pyridines; D014867:Water; C049073:droxicam; D000432:Methanol