title: Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in > or = 2nd complete remission induced by highly intensive chemotherapy.
abstract: From this retrospective single center analysis adults with acute lymphoblastic leukemia transplanted in > or 2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time,this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mengarelli
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Iori
authors.forename: Raffaella
authors.initials: R
authors.lastname: Cerretti
authors.forename: Lorenza
authors.initials: L
authors.lastname: Cerilli
authors.forename: Atelda
authors.initials: A
authors.lastname: Romano
authors.forename: William
authors.initials: W
authors.lastname: Arcese
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D012189:Retrospective Studies; D012306:Risk; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous