title: The SOCS box: a tale of destruction and degradation.
abstract: Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research and The Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria, Australia.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Kile
authors.forename: Brenda A
authors.initials: BA
authors.lastname: Schulman
authors.forename: Warren S
authors.initials: WS
authors.lastname: Alexander
authors.forename: Nicos A
authors.initials: NA
authors.lastname: Nicola
authors.forename: Helene M E
authors.initials: HM
authors.lastname: Martin
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Hilton
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008025:Ligases / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D012097:Repressor Proteins; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D044767:Ubiquitin-Protein Ligases
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D012097:Repressor Proteins; C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D044767:Ubiquitin-Protein Ligases; D008025:Ligases