title: A novel method for the analysis of the androgen receptor.
abstract: The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computer-assisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.
authors.affiliation: Department of Surgery, Division of Urology, University of North Carolina, CB# 7235, Chapel Hill, NC 27599-7235, USA.
authors.forename: Kris E
authors.initials: KE
authors.lastname: Gaston
authors.forename: O Harris
authors.initials: OH
authors.lastname: Ford III
authors.forename: Swaroop
authors.initials: S
authors.lastname: Singh
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Gregory
authors.forename: Donald E
authors.initials: DE
authors.lastname: Weyel
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Smith
authors.forename: James L
authors.initials: JL
authors.lastname: Mohler
mesh_terms: D000818:Animals; D003116:Color; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D011471:Prostatic Neoplasms / Q000737:chemistry; D011944:Receptors, Androgen / Q000032:analysis*; D014741:Video Recording
chemical_list: D011944:Receptors, Androgen