title: Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica.
abstract: The antiviral and antioxidant activity of some fractions and of a series of flavonoids and proanthocyanidins obtained from Crataegus sinaica (Rosaceae) was evaluated. The O-glycosidic flavonoids and the oligomeric proanthocyanidins exhibited significant inhibitory activity against herpes simplex virus type 1 (HSV-1), which was shown to be due to an extracellular mechanism for procyanidin C-1. Procyanidin C-1 also had the highest antioxidant activity in both the microsomal lipid peroxidation and the hydroxyl radical scavenging assay. In addition to the previously reported phenolic compounds, the pentacyclic triterpenoid ursolic acid (1) and a tetrameric (2) and pentameric procyanidin (3) are reported for the first time.
authors.forename: Abdelaaty A
authors.initials: AA
authors.lastname: Shahat
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
authors.forename: Tess
authors.initials: T
authors.lastname: De Bruyne
authors.forename: Sandra
authors.initials: S
authors.lastname: Apers
authors.forename: Fayza M
authors.initials: FM
authors.lastname: Hammouda
authors.forename: Shams I
authors.initials: SI
authors.lastname: Ismail
authors.forename: Safa
authors.initials: S
authors.lastname: Azzam
authors.forename: Magda
authors.initials: M
authors.lastname: Claeys
authors.forename: Etienne
authors.initials: E
authors.lastname: Goovaerts
authors.forename: Luc
authors.initials: L
authors.lastname: Pieters
authors.forename: Dirk
authors.initials: D
authors.lastname: Vanden Berghe
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Vlietinck
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D044946:Biflavonoids; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002522:Chlorocebus aethiops; D027825:Crataegus; D005419:Flavonoids / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D044945:Proanthocyanidins; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D014709:Vero Cells / Q000187:drug effects / Q000821:virology; D000097245:Ursolic Acid
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D000998:Antiviral Agents; D044946:Biflavonoids; D002392:Catechin; D005419:Flavonoids; D010936:Plant Extracts; D044945:Proanthocyanidins; D014315:Triterpenes; D000097245:Ursolic Acid; C013221:proanthocyanidin; C479583:procyanidin C; C017674:procyanidin