Original method for nicorandil synthesis.
Nicorandil (N-(2-hydroxy-ethyl)-nicotine amide nitrate), drug recently introduced in therapy, is used as a vasodilator through potassium channel activation. Nicorandil is obtained by treating nicotinic acid chloride hydrochloride with nitro-oxy-ethyl-amine nitrate in an organic solvent. The authors suggest a method that uses ethyl nicotinate as raw material. Thus, the drug can be obtained from indigenous raw materials, at a lower price than the imported ones, with a high purity and a good yield.
Ungureanu
M
M
School of Medical Bioengineering, Gr.T. Popa University of Medicine and Pharmacy, Iaşi.
Dănilă
G
G
D006801:Humans; D020108:Nicorandil / Q000138:chemical synthesis*; D015221:Potassium Channels; D014665:Vasodilator Agents / Q000138:chemical synthesis*
D015221:Potassium Channels; D014665:Vasodilator Agents; D020108:Nicorandil