Chromosome aberrations: past, present and future.
Spontaneous and induced chromosome aberrations have been studied over more than a century. The resolution of detection of aberrations has depended on the improvement of available techniques. An overview on the major high lights in this area of research, from the time of solid staining to fluorescence in situ hybridization technique is presented in this review.
Natarajan
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Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center, Wassenaarseweg 72, Leiden, The Netherlands. natajaran@LUMC.nl
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004330:Drosophila / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D005544:Forecasting; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009355:Neomycin / Q000494:pharmacology; D010944:Plants / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D012106:Research / Q000639:trends; D012107:Research Design; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects
D000477:Alkylating Agents; D009355:Neomycin