Mixed chimerism after bone marrow transplantation for thalassemia major.
Thirty-four thalassemia patients were studied for chimerism by fluorescent in situ hybridization or variable number tandem repeats after bone marrow transplantation. Mixed chimerism was detected in 9 patients with host cells ranging from 4 to 56%. One had graft rejection and the others were transfusion independent. Mixed chimerism was common but mostly without deleterious effect.
Li
Chi Kong
CK
Chik
Ki Wai
KW
Tsang
Kam Sze
KS
Pong
Henry
H
Shing
Matthew M K
MM
Yuen
Patrick M P
PM
D016026:Bone Marrow Transplantation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D033581:Stem Cell Transplantation / Q000379:methods / Q000592:standards; D013997:Time Factors; D018183:Transplantation Chimera / Q000097:blood*; D014184:Transplantation, Homologous / Q000379:methods / Q000592:standards; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000628:therapy*