Understanding and augmenting human intestinal adaptation: a call for more clinical research.
Since its description in the early 20th century, the phenomenon of intestinal adaptation has been the focus of considerable interest. However, there is a paucity of evidence documenting the significance of this phenomenon in man. Indeed, our understanding of intestinal adaptation is based almost exclusively on extrapolations from studies of laboratory rodents. Given the possibility of pharmacologically modifying select components of adaptation as a therapeutic strategy for patients with intestinal insufficiency, a clear understanding of human intestinal adaptation is of paramount importance.
Tavakkolizadeh
Ali
A
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Whang
Edward E
EE
D000222:Adaptation, Physiological; D000328:Adult; D000368:Aged; D002648:Child; D006801:Humans; D007410:Intestinal Diseases / Q000503:physiopathology*; D007422:Intestines / Q000503:physiopathology*; D008875:Middle Aged; D012778:Short Bowel Syndrome / Q000503:physiopathology*