[Peliosis hepatis as the cause of liver affection in a patient treated with immunosuppressive agents].
A case of peliosis hepatis in a 64-year-old woman treated with azathioprine because of a lung transplantation is described. The patient was admitted owing to epigastric pain and jaundice. Sixteen months before admission the patient had had a lung transplantation because of pulmonary emphysema. A liver biopsy showed multiple, dilated, blood-filled liver sinusoids consistent with peliosis hepatis. Besides azathioprine, the patient was treated with cyclosporine and prednisolone, but none of these drugs are known to be responsible for the development of peliosis hepatis. This rare condition, which causes liver affection in patients treated with azathioprine, should be kept in mind.
Knudsen
Anette Hygum
AH
Medicinsk gastroenterologisk afdeling S, Odense Universitetshospital, DK-5000 Odense.
D001379:Azathioprine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects*; D008875:Middle Aged; D010382:Peliosis Hepatis / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D001379:Azathioprine