European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.2.2 Chronic graft dysfunction. Immunological factors (alloimmunity).
GUIDELINE: All recipients of an allogeneic kidney graft should take life-long maintenance immunosuppressive medication. Whereas there is no immunological test to diagnose chronic allograft dysfunction, circumstantial evidence suggests that immunological factors play an important role in its pathogenesis. This evidence is based on experimental data, the beneficial effect of sharing HLA antigens between donor and recipient and post-transplantation immunological monitoring studies.
D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology*; D015166:Monitoring, Immunologic; D014184:Transplantation, Homologous