Superoxide and nitric oxide: consequences of varying rates of production and consumption: a theoretical treatment.
Simple algebraic manipulations and steady state assumptions have been applied to the elucidation of the effects of superoxide dismutase (SOD) on [NO] and [O(2)(-)], and on the rates of production of H(2)O(2) and of ONOO(-). The deductions help explain seemingly discordant published results and predictions.
Liochev
Stefan I
SI
Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Fridovich
I
I
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008962:Models, Theoretical; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism*
D005609:Free Radicals; D009566:Nitrates; D013481:Superoxides; C039642:peroxynitric acid; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase