Impact of stem cell source and conditioning regimen on erythrocyte recovery kinetics after allogeneic haematopoietic stem cell transplantation from an ABO-incompatible donor.
We evaluated erythrocyte recovery in 121 allogeneic haematopoietic stem cell transplantation (HSCT) recipients. There were 35 major and minor ABO-incompatible transplants, respectively, including 10 bi-directionally ABO-incompatible transplants. The use of peripheral blood stem cells facilitated erythrocyte recovery, regardless of the presence or absence of major ABO-incompatibility, and was associated with a frequent detection of anti-host isohaemagglutin early after minor ABO-incompatible transplantation, which was not associated with clinically relevant haemolysis. The use of a reduced-intensity regimen combining a purine analogue and busulphan did not delay erythrocyte recovery after major ABO-incompatible transplantation, suggesting this regimen had a strong activity against host plasma cell.
Kanda
Yoshinobu
Y
Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan.
Tanosaki
Ryuji
R
Nakai
Kunihisa
K
Saito
Takeshi
T
Ohnishi
Mutsuko
M
Niiya
Hironari
H
Chizuka
Aki
A
Yakushijin
Kimikazu
K
Urahama
Norinaga
N
Ueda
Kyoji
K
Iijima
Kimiko
K
Ando
Toshihiko
T
Matsubara
Hiroshi
H
Kami
Masahiro
M
Makimoto
Atsushi
A
Kobayashi
Yukio
Y
Tobinai
Kensei
K
Mineishi
Shin
S
Takaue
Yoichi
Y
D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000166:cytology*; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000601:surgery* / Q000628:therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000601:surgery; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000601:surgery; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D006388:Hemagglutinins