[Effects of factor V Leiden mutations on prognosis in patients with acute myocardial infarction].
OBJECTIVE
Factor V Leiden mutation, the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis. Factor V Leiden mutation and its relation to post-myocardial infarction (MI) complications including angina pectoris, heart failure, reinfarction and cardiac mortality has not been investigated. We aimed to investigate this relation.


METHODS
The prevalence of factor V Leiden mutation was investigated in 122 patients with first acute myocardial infarction (aged 56 +/- 11, 82 men/40 women). These patients were divided into two groups according to whether the patients had factor V Leiden mutation (Group I) or not (Group II). Post MI complications were evaluated during 18 months. Blood samples from the patients were analyzed for factor V Leiden mutation by DNA analysis, using the polymerase chain reaction (PCR).


RESULTS
Factor V Leiden was detected in 11 (9%) patients (aged; 54 +/- 10, 5 women/men) and was not detected in 111(90%) patients (aged; 56 +/- 11; 35 women/76 men) of the 122 patients. There were no significant differences between Group I and Group II in terms of post MI complications, including reinfarction (27% vs. 29%; p > 0.05, respectively), angina pectoris (45% vs. 38%; p > 0.05, respectively), heart failure (27% vs. 23%; p > 0.05, respectively) and cardiac mortality (18% vs. 14%; p > 0.05, respectively).


CONCLUSIONS
Post MI complications, including reinfarction, heart failure, angina pectoris and cardiac mortality were not increased in patients with factor V Leiden.
Baykan
M
M
Karadeniz Teknik Universitesi Tip Fakültesi Kardiyoloji. ercevdet@gul.net.tr
Celik
S
S
Uçar
F
F
Kaplan
S
S
Ovali
E
E
Erdöl
C
C
D020016:Activated Protein C Resistance / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics* / Q000401:mortality*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
C095381:factor V Leiden; D005165:Factor V