title: Detection of lung cancer on chest radiographs: analysis on the basis of size and extent of ground-glass opacity at thin-section CT.
abstract: OBJECTIVE
  To evaluate the detection of small peripheral lung tumors on chest radiographs on the basis of the size of the tumor and its extent of ground-glass opacity (GGO) at thin-section computed tomography (CT).
  
  
  METHODS
  Chest radiographs of 75 patients with peripheral carcinomas 20 mm in diameter or smaller (26 localized bronchioloalveolar carcinomas [BACs], 49 other carcinomas) and 60 normal chest radiographs were retrospectively reviewed individually by 10 radiologists. The extent of GGO within the lesions at thin-section CT was reviewed retrospectively. The detection rates for localized BAC and other carcinomas on chest radiographs were calculated and were correlated with tumor size and extent of GGO.
  
  
  RESULTS
  The mean sensitivity for detection of small peripheral carcinomas was 58.5% +/- 8.8 (standard error) for localized BAC and was 78.6% +/- 5.1 for other carcinomas (P =.024). Lesions that were smaller than 15 mm in diameter and had an extent of GGO of 70% or greater at thin-section CT were more difficult to detect than tumors that had larger diameters or less extensive GGO (chi(2) = 8.13, df = 1, P =.004).
  
  
  CONCLUSIONS
  The detection of small peripheral carcinomas on chest radiographs is influenced by tumor size and extent of GGO as seen at thin-section CT.
authors.affiliation: Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Suita, Japan. tubamoto@radiol.med.osaka-u.ac.jp
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Tsubamoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Kuriyama
authors.forename: Shoji
authors.initials: S
authors.lastname: Kido
authors.forename: Jun
authors.initials: J
authors.lastname: Arisawa
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kohno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Tomiyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Honda
authors.forename: Chikazumi
authors.initials: C
authors.lastname: Kuroda
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*