Strained silacycles in organic synthesis: a new reagent for the enantioselective allylation of aldehydes.
A new reagent for the enantioselective allylation of aliphatic aldehydes has been developed. The reagent is easily prepared in a single step from commercially available materials and may be stored without significant decomposition. The reactivity of the reagent is attributed to strain-release Lewis acidity.
Kinnaird
James W A
JW
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Ng
Pui Yee
PY
Kubota
Katsumi
K
Wang
Xiaolun
X
Leighton
James L
JL
D000438:Alcohols / Q000138:chemical synthesis*; D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D006844:Hydrocarbons, Cyclic / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*
D000438:Alcohols; D000447:Aldehydes; D006844:Hydrocarbons, Cyclic; D012821:Silanes