A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission.
We performed a clinical comparison of unrelated cord blood transplantation (UCBT) and unrelated bone marrow transplantation in adult acute leukaemia patients in complete remission (CR) who received the same conditioning regimen, graft-versus-host disease (GvHD) prophylaxis and supportive treatment. The incidence of acute GvHD was almost the same between the two groups, but the haematopoietic recovery was delayed and the incidence of chronic GvHD was higher in the UCBT group. The probability of 2 year disease-free survival was similar between the two groups. These results suggest that adult acute leukaemia patients in CR without a suitable donor should be considered as candidates for UCBT.
Ooi
Jun
J
Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. jun-ooi@ims.u-tokyo.ac.jp
Iseki
Tohru
T
Takahashi
Satoshi
S
Tomonari
Akira
A
Nagayama
Hitomi
H
Ishii
Koji
K
Ito
Kiyoshi
K
Sato
Hiroyuki
H
Takahashi
Tsutomu
T
Shindo
Motohiro
M
Sekine
Rieko
R
Ohno
Nobuhiro
N
Uchimaru
Kaoru
K
Nagamura
Fumitaka
F
Shirafuji
Naoki
N
Tojo
Arinobu
A
Tani
Kenzaburo
K
Asano
Shigetaka
S
D000328:Adult; D016026:Bone Marrow Transplantation; D018572:Disease-Free Survival; D005260:Female; D005312:Fetal Blood; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012074:Remission Induction