Thymosin alpha1 inhibits mammary carcinogenesis in Fisher rats.
The effects of thymosin alpha1 (Talpha1) on mammary carcinogenesis was investigated in Fisher rats. Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats. Daily administration of Talpha1 (10 microg, s.c.) reduced mammary carcinoma incidence and prolonged survival time. Animals treated with exogenous Talpha1 had a significantly greater blood white cell density than control Fisher rats. These results suggest that Talpha1 prevents mammary carcinoma incidence as a result of stimulation of the immune system.
Moody
Terry W
TW
Cell and Cancer Biology Branch, National Cancer Institute, 9610 Medical Center Drive, Building KWC, Rockville, MD 20850, USA. moodyt@bprb.nci.nih.gov
Tuthill
Cynthia
C
Badamchian
Mahnaz
M
Goldstein
Allan L
AL
D000818:Animals; D001774:Blood Chemical Analysis; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000276:immunology; D005260:Female; D007958:Leukocyte Count; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D008770:Methylnitrosourea / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D013947:Thymosin; D008770:Methylnitrosourea; D000077596:Thymalfasin