title: [Study of the chemical stability of acetylsalicylic acid tablets during storage in pharmacies of Concepción, Chile].
abstract: BACKGROUND
  The chemical stability of a pharmaceutical product depends, among other factors, on environmental factors during transport, storage and manipulation of the product.
  
  
  OBJECTIVE
  To study the chemical stability of acetylsalicylic acid (AAS) tablets during ten months of storage in five pharmacies of Concepción, Chile.
  
  
  METHODS
  Tablets were randomly collected at the beginning of the study and at the third, sixth and tenth month. Quantitative analyses of AAS tablets was carried out by instrumental thin layer chromatography (HPTLC).
  
  
  RESULTS
  AAS in tablets was between 99 and 109% at the beginning of the study, between 76 and 110% at three months, between 71% and 112% at six months and between 86 and 110% at ten months of storage.
  
  
  CONCLUSIONS
  There was a progressive decrease in the content of acetylsalicylic acid in tables during storage, but it remained between the limits accepted by the United States Pharmacopoeia (USP) (90-110%).
authors.affiliation: Departamentos de Farmacia y Bromatología, Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, Casilla 237 Concepción, Chile. smennick@udec.cl
authors.forename: Sigrid
authors.initials: S
authors.lastname: Mennickent
authors.forename: Tamara
authors.initials: T
authors.lastname: Yates
authors.forename: Mario
authors.initials: M
authors.lastname: Vega
authors.forename: C
authors.initials: C
authors.lastname: Gloria Godoy
authors.forename: Roberto
authors.initials: R
authors.lastname: Saelzer
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D002677:Chile; D002855:Chromatography, Thin Layer / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage; D006813:Humidity; D010594:Pharmacies; D013607:Tablets; D013696:Temperature; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; D001241:Aspirin