Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag.
The innate immune system senses microbial components by signaling receptors and induces phagocytosis by uptake receptors. The Toll-like receptor represents the signaling receptors that cause maturation of dendritic cells, while phagocytosis is supported by other receptor families. We identify the structural signatures of microbial components recognized by these receptors to establish the two-receptor hypothesis in innate immunity.
Seya
Tsukasa
T
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka, Japan. seya-tu@mc.pref.osaka.jp
Matsumoto
Misako
M
Tsuji
Shoutaro
S
Begum
Nasim A
NA
Azuma
Ichiro
I
Toyoshima
Kumao
K
D000276:Adjuvants, Immunologic; D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D002473:Cell Wall / Q000737:chemistry / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D029721:Drosophila Proteins; D007113:Immunity, Innate; D008074:Lipoproteins / Q000737:chemistry / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology* / Q000472:pathogenicity; D009174:Mycoplasma / Q000276:immunology* / Q000472:pathogenicity; D011956:Receptors, Cell Surface / Q000276:immunology; D013329:Structure-Activity Relationship; D051193:Toll-Like Receptors
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D029721:Drosophila Proteins; D008074:Lipoproteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors