title: The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.
abstract: The complete genome of the green-sulfur eubacterium Chlorobium tepidum TLS was determined to be a single circular chromosome of 2,154,946 bp. This represents the first genome sequence from the phylum Chlorobia, whose members perform anoxygenic photosynthesis by the reductive tricarboxylic acid cycle. Genome comparisons have identified genes in C. tepidum that are highly conserved among photosynthetic species. Many of these have no assigned function and may play novel roles in photosynthesis or photobiology. Phylogenomic analysis reveals likely duplications of genes involved in biosynthetic pathways for photosynthesis and the metabolism of sulfur and nitrogen as well as strong similarities between metabolic processes in C. tepidum and many Archaeal species.
authors.affiliation: The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. jeisen@tigr.org
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Eisen
authors.forename: Karen E
authors.initials: KE
authors.lastname: Nelson
authors.forename: Ian T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: John F
authors.initials: JF
authors.lastname: Heidelberg
authors.forename: Martin
authors.initials: M
authors.lastname: Wu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Dodson
authors.forename: Robert
authors.initials: R
authors.lastname: Deboy
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Gwinn
authors.forename: William C
authors.initials: WC
authors.lastname: Nelson
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Haft
authors.forename: Erin K
authors.initials: EK
authors.lastname: Hickey
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Peterson
authors.forename: A Scott
authors.initials: AS
authors.lastname: Durkin
authors.forename: James L
authors.initials: JL
authors.lastname: Kolonay
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Holt
authors.forename: Lowell A
authors.initials: LA
authors.lastname: Umayam
authors.forename: Tanya
authors.initials: T
authors.lastname: Mason
authors.forename: Michael
authors.initials: M
authors.lastname: Brenner
authors.forename: Terrance P
authors.initials: TP
authors.lastname: Shea
authors.forename: Debbie
authors.initials: D
authors.lastname: Parksey
authors.forename: William C
authors.initials: WC
authors.lastname: Nierman
authors.forename: Tamara V
authors.initials: TV
authors.lastname: Feldblyum
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Hansen
authors.forename: M Brook
authors.initials: MB
authors.lastname: Craven
authors.forename: Diana
authors.initials: D
authors.lastname: Radune
authors.forename: Jessica
authors.initials: J
authors.lastname: Vamathevan
authors.forename: Hoda
authors.initials: H
authors.lastname: Khouri
authors.forename: Owen
authors.initials: O
authors.lastname: White
authors.forename: Tanja M
authors.initials: TM
authors.lastname: Gruber
authors.forename: Karen A
authors.initials: KA
authors.lastname: Ketchum
authors.forename: J Craig
authors.initials: JC
authors.lastname: Venter
authors.forename: Hervé
authors.initials: H
authors.lastname: Tettelin
authors.forename: Donald A
authors.initials: DA
authors.lastname: Bryant
authors.forename: Claire M
authors.initials: CM
authors.lastname: Fraser
mesh_terms: D002245:Carbon Dioxide / Q000378:metabolism; D019414:Chlorobi / Q000235:genetics* / Q000378:metabolism*; D002876:Chromosomes, Bacterial / Q000235:genetics; D002952:Citric Acid Cycle; D004260:DNA Repair; D004579:Electron Transport; D020440:Gene Duplication; D016680:Genome, Bacterial; D008954:Models, Biological; D008969:Molecular Sequence Data; D009584:Nitrogen / Q000378:metabolism; D018384:Oxidative Stress; D010788:Photosynthesis; D010802:Phylogeny; D014176:Protein Biosynthesis; D011758:Pyrroles / Q000378:metabolism; D013455:Sulfur / Q000378:metabolism; D013729:Terpenes / Q000378:metabolism; D045725:Tetrapyrroles; D014158:Transcription, Genetic
chemical_list: D011758:Pyrroles; D013729:Terpenes; D045725:Tetrapyrroles; D002245:Carbon Dioxide; D013455:Sulfur; D009584:Nitrogen