NMR difference probe: a dual-coil probe for NMR difference spectroscopy.
A unique probe designed to acquire nuclear magnetic resonance difference spectra of two samples is presented. The NMR Difference Probe contains two sample coils in a resonant circuit that switches between parallel excitation and serial acquisition to cancel common signals such as solvent peaks and impurities. Two samples containing a common analyte, acetonitrile, were used to demonstrate signal cancellation in a difference spectrum collected with a single pulse experiment. The cancellation was over 96% effective. The approach described has applications in the areas of solvent subtraction and spectral simplification.
Macnaughtan
Megan A
MA
H. C. Brown Laboratory, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393, USA.
Hou
Ting
T
MacNamara
Ernesto
E
Santini
Robert E
RE
Raftery
Daniel
D
D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D012815:Signal Processing, Computer-Assisted