[Functional morphology of organotypic culture of spleens from rats of various ages exposed to vilon].
A synthetic dipeptide vilon (Lys-Glu, 20 ng/ml) was added to a cultural medium of explants taken from rats of 3 days, 3 weeks and 2 years of age. The peptide induced morphologic stability of the tissue and activated the regeneration and functional activity of cells. The stronger effect on the explants taken from the old rats suggests that vilon is a candidate for geriatric research and practice.
Kniaz'kin
I V
IV
St. Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo pr., 197110, St. Petersburg, Russia.
Iuzhakov
V V
VV
Chalisova
N I
NI
Grigor'ev
E I
EI
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D013154:Spleen / Q000187:drug effects* / Q000502:physiology
D000276:Adjuvants, Immunologic; D004151:Dipeptides; C415909:lysylglutamic acid