title: Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.
abstract: Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up the only precursor population known to migrate away from the surface of the brain. We studied the role of the chemokine stromal-derived factor 1 (SDF-1) in the cerebellar tissue of rats and knockout mice and found (i) that it functions as an attractive guidance cue for neuronal migration and (ii) that its secretion from non-neuronal meningeal tissue is important for controlling the migration of embryonic EGL cells.
authors.affiliation: Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Zhang
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Jane Y
authors.initials: JY
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Rao
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000172:deficiency / Q000494:pharmacology / Q000502:physiology*; D002630:Chemotactic Factors / Q000172:deficiency / Q000494:pharmacology / Q000502:physiology*; D018920:Coculture Techniques; D007150:Immunohistochemistry; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008578:Meninges / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects
chemical_list: D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D002630:Chemotactic Factors; C515256:Cxcl12 protein, mouse