[Immunological diagnosis of scleroderma].
Systemic sclerosis is characterized by a fibrosis and a microvascular injury. These vascular lesions can affect internal organs causing severe visceral damages. The pathogenesis of this disease is complex but some immunological disorders with a production of antinuclear auto-antibodies can be useful to the clinicians, especially for an early diagnosis and to distinguish the scleroderma/myositis overlap syndromes. This review presents the target antigens and the methods of detection of the different antinuclear auto-antibodies. Sensitivity, specificity and clinical association between the antinuclear auto-antibodies and the different subclasses of scleroderma are also presented in detail.
Fabien
Nicole
N
Laboratoire d'Auto-immunité, Service d'Immunologie, Centre Hospitalier Lyon-Sud, 69495 Pierre-Bénite, France. nicole.fabien@chu-lyon.fr
Rousset
Hugues
H
D001323:Autoantibodies / Q000032:analysis; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007158:Immunologic Techniques; D008833:Microcirculation; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000276:immunology
D001323:Autoantibodies