Aleukemic monocytic leukemia cutis.
Aleukemic leukemia cutis is a rare condition in which leukemic cells invade the skin before they appear in peripheral blood or bone marrow specimens. The condition frequently is misdiagnosed as atypical lymphoma. Generally, the diagnosis is made retrospectively, after the leukemic cells appear in peripheral blood or bone marrow samples. Immunohistochemical studies are the primary methods for diagnosis. Prognosis is usually poor. We describe the case of a 75-year-old woman with acute aleukemic monocytic leukemia cutis who developed systemic disease 1 1/2 years after skin involvement.
Barzilai
Aviv
A
Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel. avivb@post.tau.ac.il
Lyakhovitsky
Ana
A
Goldberg
Iris
I
Meytes
Dina
D
Trau
Henri
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001856:Bone Marrow Examination; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007938:Leukemia / Q000473:pathology* / Q000628:therapy; D007951:Leukemia, Myeloid / Q000473:pathology* / Q000628:therapy; D017254:Leukemic Infiltration; D011241:Prednisone / Q000627:therapeutic use; D018714:Radiotherapy, Adjuvant; D012867:Skin / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone