title: (Re-)Engineering tumor cell-selective replicating adenoviruses: a step in the right direction toward systemic therapy for metastatic disease.
abstract: An approach combining redundant controls to restrict the productive infection of adenoviruses to cells that are disrupted in the pRb pathway-a hallmark of human cancer-has resulted in a novel oncolytic virus that may be well suited for systemic administration to treat metastatic disease.
authors.affiliation: Cancer Research, Cerus Corporation, 2411 Stanwell Dr., Concord, CA 94520, USA. tom_dubensky@ceruscorp.com
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Dubensky
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D003673:Defective Viruses; D050684:E2F Transcription Factors; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D016160:Retinoblastoma Protein / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016160:Retinoblastoma Protein; D014157:Transcription Factors