title: Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes.
abstract: BACKGROUND
  Lactic acidosis after cardiac surgery is a manifestation of excess cytokine production. Cytokine-related genetic polymorphisms account for variability in cytokine response and may predispose to the development of lactic acidosis after cardiac surgery.
  
  
  METHODS
  Routine postoperative cardiac surgery patients were studied. Lactic acid levels were greater than 4 mmol/L in study patients and less than 4 mmol/L in controls. Polymerase chain reaction-based techniques were used to examine carriage of tumor necrosis factor beta (TNF-beta), TNF G-308A, and interleukin 10 (IL-10) G-1082A alleles.
  
  
  RESULTS
  Demographic characteristics and details of surgery were similar for 30 control and 21 study patients. Lactic acid levels after intensive care admission changed over time and were related to both TNF-beta and IL-10 G-1082A polymorphisms. All 4 study patients homozygous for TNF-beta1 and carrying an IL-10-1082A allele developed lactic acidosis (p = 0.02). There was no relation between the rate of epinephrine infusion or duration of cardiopulmonary bypass and lactic acid levels.
  
  
  CONCLUSIONS
  Genetic factors have a role in the development of lactic acidosis after cardiac surgery.
authors.affiliation: Department of Anaesthesia, St. James's Hospital, Dublin, Ireland. ryants@iol.ie
authors.forename: Thomas
authors.initials: T
authors.lastname: Ryan
authors.forename: Joanna
authors.initials: J
authors.lastname: Balding
authors.forename: Eilis M
authors.initials: EM
authors.lastname: McGovern
authors.forename: John
authors.initials: J
authors.lastname: Hinchion
authors.forename: Wendy
authors.initials: W
authors.lastname: Livingstone
authors.forename: Zeb
authors.initials: Z
authors.lastname: Chughtai
authors.forename: Owen P
authors.initials: OP
authors.lastname: Smith
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology / Q000235:genetics*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10