title: Opinion: Building epithelial architecture: insights from three-dimensional culture models.
abstract: How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.
authors.affiliation: Department of Anatomy, and the Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA.
authors.forename: Lucy Erin
authors.initials: LE
authors.lastname: O'Brien
authors.forename: Mirjam M P
authors.initials: MM
authors.lastname: Zegers
authors.forename: Keith E
authors.initials: KE
authors.lastname: Mostov
mesh_terms: D000818:Animals; D002450:Cell Communication; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology* / Q000187:drug effects; D017228:Hepatocyte Growth Factor / Q000494:pharmacology; D006801:Humans; D009024:Morphogenesis
chemical_list: D017228:Hepatocyte Growth Factor