title: Leukemia in donor cells after allogeneic hematopoietic stem cell transplant.
abstract: The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34(+) cells.
authors.affiliation: Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Brunstein
authors.forename: B A
authors.initials: BA
authors.lastname: Hirsch
authors.forename: D
authors.initials: D
authors.lastname: Hammerschmidt
authors.forename: R C
authors.initials: RC
authors.lastname: McGlennen
authors.forename: P L
authors.initials: PL
authors.lastname: Nguyen
authors.forename: C M
authors.initials: CM
authors.lastname: Verfaillie
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D018598:Minisatellite Repeats; D009190:Myelodysplastic Syndromes / Q000473:pathology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D014019:Tissue Donors; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous