Cigarette smoking and the risk of mucinous and nonmucinous epithelial ovarian cancer.
BACKGROUND
The association between cigarette smoking and ovarian cancer may vary according to the histologic type of tumor.


METHODS
We examined cigarette smoking as a risk factor for both mucinous and nonmucinous tumors in a population-based case-control study comparing 767 incident cases of epithelial ovarian cancer with 1,367 community controls frequency matched to cases by age and race.


RESULTS
Smoking was associated with mucinous tumors (odds ratio [OR] = 1.9; 95% confidence interval [CI] = 1.3-2.9) but not with nonmucinous tumors (OR = 1.1; CI = 0.9-1.3). Furthermore, the odds ratios for smokers with mucinous tumors increased with increasing pack-years of smoking (OR = 1.0, 1.9, and 2.7 for <5, 5-24, and > 24+ pack-years, respectively; P for trend = 0.01)


CONCLUSIONS
Cigarette smoking appears to be a risk factor for mucinous but not for nonmucinous tumors.
Modugno
Francesmary
F
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA. fm@cs.cmu.edu
Ness
Roberta B
RB
Cottreau
Carrie M
CM
D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*