Nonrobertsonian translocation t(6;11) is associated with infertility in an oligoazoospermic male.
OBJECTIVE
To analyze an unusual nonrobertsonian translocation t(6;11) found in an infertile, oligoazoospermic, but otherwise apparently healthy man.


METHODS
Case report with review of the scientific literature.


METHODS
Academic research environment.


METHODS
Infertile, oligoazoospermic, but otherwise apparently healthy man.


METHODS
Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by standard GBG, RBG, and CBG banding procedures.


METHODS
Sperm count, morphology, and GBG, RBG, and CBG banding.


RESULTS
A karyogram revealed a nonrobertsonian balanced translocation t(6;11) with breakpoints at 6q15 and 11p15, as shown by R-, G-, and C-banding.


CONCLUSIONS
Physical contact of unpaired autosomal material with sex chromosomes, which leads to spermatogenic arrest, may be one of the factors that accounts for infertility in men with autosomal aberrations.
Pernice
Francesco
F
Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Messina, Messina, Italy. fpernice@tiscali.it
Mazza
Giuseppa
G
Puglisi
Domenico
D
Luppino
Maria Giuseppa
MG
Frisina
Nicola
N
D000328:Adult; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D020732:Cytogenetic Analysis; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*