[Molecular mechanisms of apoptosis. Fas and TNF systems. ICE protease system. Bcl-2 family].
For every cell is a time to live and a time to die. The cell death that occurs during embryogenesis, normal tissue turnover, pathological conditions like cancer cells, etc. is "programmed cell death" or apoptosis. In this study we report on apoptosis mediated by cytokines. Fas ligand and tumor necrosis factor bind to their receptors and induce apoptosis.
Goga
L M
LM
Disciplina de Biologie Celulară şi Moleculară, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Vasiliu
O M
OM
Ionescu
C R
CR
D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000502:physiology*; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019253:Proto-Oncogene Proteins c-bcl-2; D014409:Tumor Necrosis Factor-alpha; D020169:Caspases