Dementing disorders: volumetric measurement of cerebrospinal fluid to distinguish normal from pathologic findings -- feasibility study.
The authors describe a magnetic resonance (MR) imaging technique to quantify the severity and distribution of cerebral atrophy by using automated volumetric analysis of the distribution of cerebrospinal fluid. The MR imaging technique demonstrated high diagnostic sensitivity and specificity in a group of healthy subjects and patients with dementing diseases. The authors conclude that this approach provides valuable clinical information that is complementary to information acquired with standard diagnostic practices.
Thacker
Neil A
NA
Division of Imaging Science and Biomedical Engineering, Medical School, University of Manchester, Oxford Rd, Manchester M13 9PT, England. neil.thacker@man.ac.uk
Varma
Anoop R
AR
Bathgate
Deborah
D
Stivaros
Stavros
S
Snowden
Julie S
JS
Neary
David
D
Jackson
Alan
A
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid / Q000175:diagnosis; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity