title: Personality, brain asymmetry, and neuroendocrine reactivity in two immune-mediated disorders: a preliminary report.
abstract: Development of some immune-mediated disorders may depend on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To explore neuropsychologic mechanisms in relation to the abnormal endocrine reactivity in patients with systemic lupus erythematosus (SLE) and chronic hepatitis C (CHC) we used the corticotropin releasing hormone (CRH) test, the Minnesota Multiphasic Personality Inventory (MMPI), and the Edinburgh Inventory of Manual Preference Inventory (EIMP). Compared to controls, the adrenocorticotrophic hormone (ACTH) response to CRH was reduced in CHC, while SLE presented reduced baseline dehydroepiandrosterone sulfate levels; higher neurotic scores were found in SLE and higher behavior deviant scores in CHC. Peak ACTH levels were a significant factor for the MMPI profile variability, while the manual preference score was a significant factor for the ACTH response. Personality and manual preference contribute to neuroendocrine abnormalities. Different behavioral and neuroimmunoendocrine models emerge for these disorders.
authors.affiliation: Endocrine Department, Hospital de Curry Cabral, Lisbon, Portugal. rop25748@mail.telepac.pt
authors.forename: J Martin
authors.initials: JM
authors.lastname: Martins
authors.forename: J
authors.initials: J
authors.lastname: Alves
authors.forename: Ana
authors.initials: A
authors.lastname: Trinca
authors.forename: Bruno
authors.initials: B
authors.lastname: Grima
authors.forename: S
authors.initials: S
authors.lastname: do Vale
authors.forename: Teresa
authors.initials: T
authors.lastname: Vasconcelos
authors.forename: Nuno
authors.initials: N
authors.lastname: Riso
authors.forename: Vaz
authors.initials: V
authors.lastname: Riscado
authors.forename: J Charneco
authors.initials: JC
authors.lastname: da Costa
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001921:Brain / Q000276:immunology / Q000503:physiopathology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D007839:Functional Laterality; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000503:physiopathology / Q000523:psychology; D008950:MMPI; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000276:immunology* / Q000503:physiopathology; D010551:Personality; D010865:Pilot Projects; D011388:Prolactin / Q000097:blood
chemical_list: D019314:Dehydroepiandrosterone Sulfate; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D006854:Hydrocortisone