title: Cigarette smoking and the risk of mucinous and nonmucinous epithelial ovarian cancer.
abstract: BACKGROUND
  The association between cigarette smoking and ovarian cancer may vary according to the histologic type of tumor.
  
  
  METHODS
  We examined cigarette smoking as a risk factor for both mucinous and nonmucinous tumors in a population-based case-control study comparing 767 incident cases of epithelial ovarian cancer with 1,367 community controls frequency matched to cases by age and race.
  
  
  RESULTS
  Smoking was associated with mucinous tumors (odds ratio [OR] = 1.9; 95% confidence interval [CI] = 1.3-2.9) but not with nonmucinous tumors (OR = 1.1; CI = 0.9-1.3). Furthermore, the odds ratios for smokers with mucinous tumors increased with increasing pack-years of smoking (OR = 1.0, 1.9, and 2.7 for <5, 5-24, and > 24+ pack-years, respectively; P for trend = 0.01)
  
  
  CONCLUSIONS
  Cigarette smoking appears to be a risk factor for mucinous but not for nonmucinous tumors.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA. fm@cs.cmu.edu
authors.forename: Francesmary
authors.initials: F
authors.lastname: Modugno
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Ness
authors.forename: Carrie M
authors.initials: CM
authors.lastname: Cottreau
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*