title: Lack of association between estrogen receptor 1 gene polymorphisms and multiple sclerosis in southern Italy in humans.
abstract: Estrogen receptor 1 gene polymorphisms (ESR1) have been found to be associated with multiple sclerosis (MS) in both Japanese and Finnish populations. We investigated the association between ESR1 polymorphisms (PvuII and XbaI) and MS in a study of 132 MS patients and 129 controls from the same geographic background (southern Italy). Allelic and genotypic frequencies were not different between MS patients and population controls for either the PvuII or XbaI polymorphism. This result suggests that the association between a given disease and a genomic characteristic must be confirmed by separate investigations in different populations.
authors.affiliation: Institute of Neurology, University of Palermo, Palermo, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Savettieri
authors.forename: Rita
authors.initials: R
authors.lastname: Cittadella
authors.forename: Paola
authors.initials: P
authors.lastname: Valentino
authors.forename: Ida
authors.initials: I
authors.lastname: Manna
authors.forename: Virginia
authors.initials: V
authors.lastname: Andreoli
authors.forename: Antonella
authors.initials: A
authors.lastname: La Russa
authors.forename: Gaetana
authors.initials: G
authors.lastname: La Porta
authors.forename: Francesca
authors.initials: F
authors.lastname: Ruscica
authors.forename: Paolo
authors.initials: P
authors.lastname: Ragonese
authors.forename: Domenico
authors.initials: D
authors.lastname: Pirritano
authors.forename: Simona
authors.initials: S
authors.lastname: Bonavita
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D047628:Estrogen Receptor alpha; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*
chemical_list: D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen