title: Short-step syntheses of all stereoisomers of preussin and their bioactivities.
abstract: All the eight stereoisomers of (+)-preussin (1b), an antifungal agent inhibiting the growth of fission yeast and human cancer cells, were synthesized in two steps by non-stereoselective reactions and chromatographic separation, starting from L- and D-N-protected-phenylalaninal (2). Their bioassay revealed all of the stereoisomers to be almost equally bioactive.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Okue
authors.forename: Hidenori
authors.initials: H
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Kasahara
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Sueharu
authors.initials: S
authors.lastname: Horinouchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitahara
mesh_terms: D000841:Anisomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D012568:Schizosaccharomyces / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000935:Antifungal Agents; C058280:preussin; D000841:Anisomycin