title: The value of mediastinoscopy in preoperative evaluation of mediastinal involvement in non-small-cell lung cancer patients with clinical NO disease.
abstract: BACKGROUND
  The efficacy of mediastinal lymph node examination using cervical mediastinoscopy in operable non-small cell lung cancer patients without radiological nodal involvement on computerized tomography (CT) has been elusive.
  
  
  METHODS
  The value of mediastinoscopy as a staging modality for assessing the mediastinal lymph node status was evaluated in 79 patients with presumed resectable non-small-cell lung cancer (NSCLC) with mediastinal nodes smaller than 1 cm (NO) form the CT scan. Sixty-one patients who did not have nodal involvement at mediastinoscopy and had complete medical records underwent complete resection.
  
  
  RESULTS
  Negative predictive value (NPV) of the CT scan according to mediastinoscopy was 92.4 %. Histopathological examination of the surgical specimen showed the NPV of mediastinoscopy to be 93.4 %. Only 4 patients (3 patients with N2, 1 patient with N3 disease) were not correctly staged using CT scanning and mediastinoscopy. According to the pathological examination, the NPV of CT was found to be lower (76.5 %) in patients with adenocarcinoma, but the difference was not statistically significant (p > 0.128)
  
  
  CONCLUSIONS
  Although the likelihood of surgical-pathological N2 is slightly higher in patients with adenocarcinoma, radiological examination of patients with cNO NSCLC disease can be as accurate as mediastinoscopy in appropriately staging mediastinal lymph node involvement.
authors.affiliation: Yedikule Hospital for Chest Disease and Thoracic Surgery, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Gürses
authors.forename: A
authors.initials: A
authors.lastname: Turna
authors.forename: M A
authors.initials: MA
authors.lastname: Bedirhan
authors.forename: T
authors.initials: T
authors.lastname: Ozalp
authors.forename: C
authors.initials: C
authors.lastname: Kocatürk
authors.forename: A
authors.initials: A
authors.lastname: Demir
authors.forename: M
authors.initials: M
authors.lastname: Ozcan
authors.forename: N
authors.initials: N
authors.lastname: Urer
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000556:secondary; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008297:Male; D008481:Mediastinoscopy; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed