[Apoptosis of CD4(+) T cells during experimental autoimmune neuritis in Wistar rats].
The present study describes apoptosis of T cells in the sciatic nerve in Wistar rats with experimental autoimmune neuritis(EAN). Morphological characterizations of apoptosis were found at the 18th day from onset, peaked at the 22nd day by immunocytochemical analysis. In situ end labeling(ISEL) techniques confirmed the presence of DNA fragmentation in CD4(+) T cells. It is suggested that apoptosis is an important clearance mechanism of infiltrated T cells in the peripheral nervous system(PNS) in EAN.
Peng
Y
Y
Department of Neurology, Third Affiliated Hospital, Hunan Medical University, Changsha 410013.
Xiao
B
B
Feng
D
D
Yang
H
H
Zi
X
X
Xie
G
G
D000818:Animals; D017209:Apoptosis; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology*; D008297:Male; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D020426:Sciatic Neuropathy / Q000276:immunology