title: Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag.
abstract: The innate immune system senses microbial components by signaling receptors and induces phagocytosis by uptake receptors. The Toll-like receptor represents the signaling receptors that cause maturation of dendritic cells, while phagocytosis is supported by other receptor families. We identify the structural signatures of microbial components recognized by these receptors to establish the two-receptor hypothesis in innate immunity.
authors.affiliation: Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka, Japan. seya-tu@mc.pref.osaka.jp
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Seya
authors.forename: Misako
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Shoutaro
authors.initials: S
authors.lastname: Tsuji
authors.forename: Nasim A
authors.initials: NA
authors.lastname: Begum
authors.forename: Ichiro
authors.initials: I
authors.lastname: Azuma
authors.forename: Kumao
authors.initials: K
authors.lastname: Toyoshima
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D002473:Cell Wall / Q000737:chemistry / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D029721:Drosophila Proteins; D007113:Immunity, Innate; D008074:Lipoproteins / Q000737:chemistry / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology* / Q000472:pathogenicity; D009174:Mycoplasma / Q000276:immunology* / Q000472:pathogenicity; D011956:Receptors, Cell Surface / Q000276:immunology; D013329:Structure-Activity Relationship; D051193:Toll-Like Receptors
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D029721:Drosophila Proteins; D008074:Lipoproteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors