Changes in the leukocyte distribution and surface expression of adhesion molecules induced by hypothalamic stimulation in the cat.
Emotions and the neuroendocrine system are known to affect leukocyte distribution. However, there have so far been few reports on the relationship between hypothalamically induced emotional behavior and the endocrine-immune response. We previously reported changes in the leukocyte distribution and adhesion molecules induced by anteromedial hypothalamus stimulation (AH stimulation), which elicits restlessness behaviors in the cat. In this study, we examined ventromedial hypothalamus stimulation (VMH stimulation), which elicits threat behaviors. In addition, the endocrine responses after VMH stimulation were evaluated. VMH stimulation as well as AH stimulation induced elevations of plasma cortisol and epinephrine levels and granulocytosis and lymphopenia. In contrast, VMH stimulation induced only an elevation of plasma norepinephrine and elicited an opposite pattern of CD62L expression on the leukocyte subpopulations. The different endocrine-immunological reactions between VMH stimulation and AH stimulation were thus associated with different types of behavioral responses.
Kaname
H
H
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. kaname@npsych.med.kyushu-u.ac.jp
Mori
Y
Y
Sumida
Y
Y
Kojima
K
K
Kubo
C
C
Tashiro
N
N
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000166:cytology; D002415:Cats; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004558:Electric Stimulation; D004644:Emotions / Q000502:physiology; D004837:Epinephrine / Q000097:blood; D005260:Female; D006098:Granulocytes / Q000737:chemistry / Q000166:cytology; D006854:Hydrocortisone / Q000097:blood; D007031:Hypothalamus / Q000276:immunology*; D019041:L-Selectin / Q000378:metabolism*; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism*; D015213:Neuroimmunomodulation / Q000276:immunology; D009638:Norepinephrine / Q000097:blood
D015815:Cell Adhesion Molecules; D019041:L-Selectin; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine