title: SIV-associated lymphomas in rhesus monkeys (Macaca mulatta) in comparison with HIV-associated lymphomas.
abstract: A retrospective study was performed to characterize malignant lymphomas of 16 Simian immunodeficiency virus (SIV)-infected rhesus monkeys (Macaca mulatta), 2-9 years of age, on the basis of clinical data, histologic and immunophenotypic results, and cell death indices compiled with the TdT-mediated X-duTP nick end labeling method. We particularly focused on providing immunohistochemical evidence of expression products of EBNA2, Bc12, c-Myc, P21, P53, and Bc16. Results were compared with data from the literature on human HIV-associated lymphomas. According to the updated Kiel classification, the lymphomas were classified as 11 centroblastic lymphomas, three immunoblastic lymphomas, one Burkitt-like lymphoma, and one immunocytoma. Using antibodies to CD20, the B-cell origin of tumor cells was demonstrated. SIV antigen was not demonstrated in the tumor cells. Infection with rhesus lymphocryptovirus was present in 94% of the monkeys. Lymphomas revealed expression of Bc12 in 15/16 (94%), c-Myc in 14/16 (88%), P21 in 10/ 16 (63%), P53 in 12/16 (75%), and Bc16 in 1/16 (6%) monkeys. This study provided evidence that the expression of these gene products, which are thought to play an important role in cell proliferation and apoptosis in HIV- and non-HIV-associated lymphomas, are also involved in the pathogenesis of lymphomas in SIV-infected rhesus monkeys. A tentative relationship between the described gene products and the cell death indices was established for the expression of Bc12. The present primate model represents a suitable animal model for studying the pathogenesis of AIDS-associated lymphomas.
authors.affiliation: German Primate Center, Göttingen.
authors.forename: K
authors.initials: K
authors.lastname: Kahnt
authors.forename: K
authors.initials: K
authors.lastname: Mätz-Rensing
authors.forename: P
authors.initials: P
authors.lastname: Hofmann
authors.forename: C
authors.initials: C
authors.lastname: Stahl-Hennig
authors.forename: F J
authors.initials: FJ
authors.lastname: Kaup
mesh_terms: D000818:Animals; D006678:HIV / Q000302:isolation & purification*; D015658:HIV Infections / Q000473:pathology / Q000662:veterinary*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000662:veterinary*; D008253:Macaca mulatta; D018419:Primate Diseases / Q000473:pathology*; D012189:Retrospective Studies; D016097:Simian Acquired Immunodeficiency Syndrome / Q000473:pathology*; D015302:Simian Immunodeficiency Virus / Q000502:physiology*