title: Source analysis of polyspike and wave complexes in juvenile myoclonic epilepsy.
abstract: We applied dipole modeling and brain distributed source analysis to find current sources comprising spikes and slow waves of polyspike and wave complexes (PSWC) in patients with juvenile myoclonic epilepsy (JME). The dipoles were localized in frontal, parietal and temporal lobes. The frontal dipoles were clustered in the frontal medial gyrus and fronto-orbital region. A midsagittal frontal current source was observed using brain distributed source analysis in all patients. When the slow wave was analyzed, multiple sources in different cortical regions were detected using dipole modeling and brain distributed analysis. These results show pre-frontal medial current sources corresponding to spikes and many diffuse sources in cortical regions corresponding to wave components of PSWC in patients with JME.
authors.affiliation: Centro de Neurobiología, Campus UNAM-UAQ Juriquilla, Querétaro, México. santiago@calli.cnb.unam.mx
authors.forename: Efraín
authors.initials: E
authors.lastname: Santiago-Rodríguez
authors.forename: Thalía
authors.initials: T
authors.lastname: Harmony
authors.forename: Antonio
authors.initials: A
authors.lastname: Fernández-Bouzas
authors.forename: Adriana
authors.initials: A
authors.lastname: Hernández-Balderas
authors.forename: Manuel
authors.initials: M
authors.lastname: Martínez-López
authors.forename: Alicia
authors.initials: A
authors.lastname: Graef
authors.forename: Juan
authors.initials: J
authors.lastname: Carlos García
authors.forename: Thalía
authors.initials: T
authors.lastname: Fernández
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000503:physiopathology*