Eph family functions from an evolutionary perspective.
Eph receptor tyrosine kinases and ephrins have been identified in organisms ranging from sponges to flies and worms to chick, mice and humans, thus allowing their function to be approached also from an evolutionary perspective. The structural analysis of Eph/ephrin crystals is providing hints for the existence of Eph and ephrin folds in plants and suggests a mechanism for triggering bi-directional signalling.
Drescher
Uwe
U
MRC Centre for Developmental Neurobiology, King's College London, New Hunt's House, London, UK. uwe.drescher@kcl.ac.uk
D000818:Animals; D036342:Ephrins / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D005810:Multigene Family; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D036081:Receptors, Eph Family / Q000235:genetics* / Q000502:physiology; D012160:Retina / Q000502:physiology; D013477:Superior Colliculi / Q000502:physiology
D036342:Ephrins; D036081:Receptors, Eph Family