title: Does chloroquine really act through oxidative stress?
abstract: To assess whether molecular oxygen and oxidative stress contribute to chloroquine activity, we cultivated strains of Plasmodium falciparum in erythrocytes with carboxyhemoglobin and an atmosphere containing 2% CO, 5% CO(2) and 93% N(2). Results indicate that, contrary to common belief, oxygen is not involved in the activity of chloroquine. Reactive radicals formation is suggested.
authors.affiliation: Department of Organic Chemistry, University of Milan, CNR-ISTM, Via Venezian 21, Italy. diego.monti@unimi.it
authors.forename: Diego
authors.initials: D
authors.lastname: Monti
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Basilico
authors.forename: Silvia
authors.initials: S
authors.lastname: Parapini
authors.forename: Erica
authors.initials: E
authors.lastname: Pasini
authors.forename: Piero
authors.initials: P
authors.lastname: Olliaro
authors.forename: Donatella
authors.initials: D
authors.lastname: Taramelli
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D002245:Carbon Dioxide; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D002738:Chloroquine / Q000737:chemistry / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology; D006801:Humans; D015394:Molecular Structure; D009584:Nitrogen; D018384:Oxidative Stress; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000962:Antimalarials; D002245:Carbon Dioxide; D002248:Carbon Monoxide; D002738:Chloroquine; D002263:Carboxyhemoglobin; D009584:Nitrogen