Biomaterials and scaffolds in reparative medicine.
Most approaches currently pursued or contemplated within the framework of reparative medicine, including cell-based therapies, artificial organs, and engineered living tissues, are dependent on our ability to synthesize or otherwise generate novel materials, fabricate or assemble materials into appropriate 2-D and 3-D forms, and precisely tailor material-related physical and biological properties so as to achieve a desired clinical response. This paper summarizes the scientific and technological opportunities within the fields of biomaterials science and molecular engineering that will likely establish new enabling technologies for cellular and molecular therapies directed at the repair, replacement, or reconstruction of diseased or damaged organs and tissues.
Chaikof
Elliot L
EL
Department of Surgery, School of Medicine, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA. echaiko@emory.edu
Matthew
Howard
H
Kohn
Joachim
J
Mikos
Antonios G
AG
Prestwich
Glenn D
GD
Yip
Christopher M
CM
D000818:Animals; D001672:Biocompatible Materials; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D036103:Nanotechnology; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing
D001672:Biocompatible Materials