Transcription repair coupling factor: a very pushy enzyme.
An irreversibly stalled RNA polymerase (RNAP) in the coding region of an active gene blocks transcription and can lead to the loss of genome integrity. A recent study of the bacterial Mfd protein (Park et al., 2002 [Cell volume 109]) provides new insight into mechanisms that release RNAP from sites of arrest such as noncoding DNA lesions.
Svejstrup
Jesper Q
JQ
Cancer Research UK London Research Institute, Clare Hall Laboratory, South Mimms, EN6 3LD, UK.
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair; D046911:Macromolecular Substances; D008957:Models, Genetic; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D046911:Macromolecular Substances; D014157:Transcription Factors; C072103:transcription repair coupling factor protein, Bacteria; D004247:DNA