RIM1: an edge for presynaptic plasticity.
Pioneering work suggests that a synaptic active zone protein, RIM1, regulates both short- and long-term glutamatergic presynaptic plasticity at certain synapses. In short-term plasticity, RIM1 accelerates the priming of synaptic vesicles for fusion; by contrast, in long-term potentiation of mossy fiber synapses in the hippocampal CA3 region, phosphorylated RIM1 acts through an unknown molecular pathway to enhance release of the excitatory neurotransmitter glutamate.
Lonart
György
G
Department of Pathology and Anatomy, Eastern Virginia Medical School, PO Box 1980, Norfolk, VA 23501, USA. lonartg@evms.edu
D000818:Animals; D005089:Exocytosis / Q000502:physiology; D019204:GTP-Binding Proteins; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology; D019599:Mossy Fibers, Hippocampal / Q000378:metabolism* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism* / Q000648:ultrastructure
D009419:Nerve Tissue Proteins; C491492:RIMS1 protein, human; C107293:Rim protein, mammalian; C491489:Rims1 protein, rat; C485548:UNC13B protein, human; D019204:GTP-Binding Proteins