title: Muscle-related traits in cattle: The role of the myostatin gene in the South Devon breed.
abstract: In this paper, we examined the effects of an 11-bp mutation within the GDF-8 gene, originally identified in Belgian Blue cattle, in the South Devon breed. The mutation was found at moderate frequency (0.37) in the South Devon population. We quantified the effects of this mutation on growth, body composition and calving traits in South Devon cattle. We found that the mutation significantly increased muscle score and calving difficulty and decreased fat depth. The mutation did not significantly affect weight at 200 and 400 days or muscle depth. Its effect on muscle score and fat depth was additive while its effect on calving difficulty was recessive. The mutation accounted for a significant proportion of the phenotypic variance in muscle score and calving difficulty. There was an economic benefit of the mutation for this data set, however, calculations were sensitive to changes in the parameter values. Additional data would be required to refine these calculations.
authors.affiliation: Roslin Institute, Roslin, Midlothian, EH25 9PS, UK. Pam.Wiener@bbsrc.ac.uk
authors.forename: Pamela
authors.initials: P
authors.lastname: Wiener
authors.forename: Judith Alexis
authors.initials: JA
authors.lastname: Smith
authors.forename: Alyson Margaret
authors.initials: AM
authors.lastname: Lewis
authors.forename: John Arthur
authors.initials: JA
authors.lastname: Woolliams
authors.forename: John Lewis
authors.initials: JL
authors.lastname: Williams
mesh_terms: D000818:Animals; D001835:Body Weight; D002352:Carrier Proteins / Q000235:genetics; D002417:Cattle; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006984:Hypertrophy; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009133:Muscular Atrophy / Q000235:genetics*; D009154:Mutation; D055435:Myostatin; D010641:Phenotype; D013045:Species Specificity; D016212:Transforming Growth Factor beta / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D055435:Myostatin; D016212:Transforming Growth Factor beta