[Colonic necrosis caused by sodium polystyrene (kayexalate) in hemodialysis: myth or reality? Two case reports].
Among gastro-intestinal complications reported in uremic or transplanted patients, colonic necrosis due to Kayexalate and sorbitol is not so unusual for english authors. This iatrogenic event is probably underestimated by physicians and pathologists. In France, neither literature nor pharmacovigilance refer this complication but Vidal dictionary advises against such association. We thought of interest to report 2 representative observations and, after reviewing literature, to discuss diagnostics circumstances and etiopathogenic hypothesis and then to give some advices.
Montagnac
R
R
Service de néphrologie-hémodialyse, Centre hospitalier de Troyes. richard.montagnac@ch-troyes.fr
Méhaut
S
S
Blaison
D
D
Schillinger
F
F
D002411:Cation Exchange Resins / Q000009:adverse effects*; D003106:Colon / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007049:Iatrogenic Disease; D009336:Necrosis; D011137:Polystyrenes / Q000009:adverse effects*; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods
D002411:Cation Exchange Resins; D011137:Polystyrenes; C003321:polystyrene sulfonic acid