The absorption and excretion of fluoride and arsenic in humans.
The absorption and excretion of fluoride and arsenic were measured in a group of healthy volunteers given drinking water with naturally high concentration of fluoride (F 2.3 mg/l)(,) or high concentration of arsenic (As 0.15 mg/l), or high concentrations of both fluoride and arsenic (F 2.25 mg/l, As 0.23 mg/l and F 4.05 mg/l, As 0.58 mg/l), respectively. The results indicated that, for arsenic, the absorption rate, the proportion of urinary excretion and the biological-half-life did not show statistically significant differences between drinking water containing high arsenic alone and drinking water containing different levels of high arsenic and fluoride. Excretion and retention of arsenic were positively correlated to the total arsenic intake. Similar results were observed for fluoride. This suggests that there are different metabolic processes for arsenic and fluoride in respect to absorption and excretion; and no joint action can be attributed by these two elements.
Zheng
Yujian
Y
College of Public Health, Xinjiang Medical University, Urumqi 830054, People's Republic of China. zhyujian@xj.cninfo.net
Wu
Jiyao
J
Ng
Jack C
JC
Wang
Guoquan
G
Lian
Wu
W
D000284:Administration, Oral; D000328:Adult; D001151:Arsenic / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
D014874:Water Pollutants, Chemical; D001151:Arsenic; D005459:Fluorides