title: Two fatty acids can replace one phospholipid in condensed complexes with cholesterol.
abstract: We report that the monolayer phase diagram for binary mixtures of dimyristoylphosphatidylethanolamine (DMPE) and dihydrocholesterol (DChol) is largely unchanged when each phospholipid molecule is replaced by two myristic acid (MA) molecules or various mixtures of the lysophospholipid and myristic acid. The corresponding phase diagrams all show the formation of "condensed complexes" of DChol and lipid. The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule.
authors.affiliation: Department of Chemistry, Stanford University, CA 94305, USA.
authors.forename: Tamara M
authors.initials: TM
authors.lastname: Okonogi
authors.forename: Arun
authors.initials: A
authors.lastname: Radhakrishnan
authors.forename: Harden M
authors.initials: HM
authors.lastname: McConnell
mesh_terms: D004083:Cholestanol / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000737:chemistry; D008246:Lysophospholipids / Q000737:chemistry; D008563:Membrane Lipids / Q000737:chemistry; D015394:Molecular Structure; D019814:Myristic Acid / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; D008051:Lipid Bilayers; D008246:Lysophospholipids; D008563:Membrane Lipids; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C008301:lysophosphatidylethanolamine; D019814:Myristic Acid; D004083:Cholestanol; D002784:Cholesterol; C018525:1,2-dimyristoylphosphatidylethanolamine