title: [Effects of high iodine doses in parenteral roentgen contrast media administration on parameters of the pro-/antioxidant balance].
abstract: The aim of this study was to investigate effects of high iodine doses given parenterally as contrast medium on parameters of lipid status and thyroid hormone status as well as on parameters of the pro/antioxidative balance of spa patients. 29 patients with a comparable indication who had to undergo an angiography were chosen. The blood parameters of these patients were determined before and after the angiographic treatment. No provable changes of the thyroid parameters f-T3, f-T4 and TSH were found after the angiography. In case of enzyme activities, the protective enzymes SOD and GSHPX showed no changes, while the concentrations of peroxides and MDA were increased significantly. Corresponding to this, the total antioxidative status and the vitamin E level decreased significantly. Altogether these results stand for a moderate deterioration of the antioxidative protective potential by the highly iodine containing contrast medium.
authors.affiliation: Paracelsus-Gesellschaft für Balneologie und Jodforschung, Dr. Karl-Renner-Strasse 6, A-4540 Bad Hall. paracelsus.badhall@utanet.at
authors.forename: R
authors.initials: R
authors.lastname: Winkler
authors.forename: S
authors.initials: S
authors.lastname: Griebenow
authors.forename: B
authors.initials: B
authors.lastname: Scheidleder
authors.forename: H
authors.initials: H
authors.lastname: Bailer
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000534:rehabilitation; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006294:Health Resorts; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010545:Peroxides / Q000097:blood*; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D003287:Contrast Media; D010545:Peroxides; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D007479:Iopamidol