The pathophysiology of the fetus of the diabetic mother.
The metabolic processes that are responsible for the pathophysiology of the fetus of the diabetic mother have been elucidated in recent years and include maternal hyperglycinemia, fetal hyperglycinemia, fetal hyperinsulinemia, and increased levels of maternal, placental, and fetal insulin-like growth factors. Counter-regulatory mechanisms, such as insulin-like growth factors binding proteins and leptin also play a role. The fetal hypermetabolic state leads to increased somatic growth, obesity, and metabolic disturbances with short- and long-term consequences.
Eidelman
Arthur I
AI
Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel. eidel@cc.huji.ac.il
Samueloff
Arnon
A
D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology*; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D005333:Fetus / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism / Q000503:physiopathology; D006946:Hyperinsulinism / Q000378:metabolism / Q000503:physiopathology; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D020738:Leptin; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism / Q000503:physiopathology*; D013002:Somatomedins / Q000378:metabolism
D018969:Insulin-Like Growth Factor Binding Proteins; D020738:Leptin; D013002:Somatomedins