title: Myoclonic involuntary movement associated with chronic manganese poisoning.
abstract: We report a 17-year-old man showing myoclonic involuntary movement (IVM) associated with chronic manganese (Mn) poisoning. The patient, a welder, showed myoclonic IVM mainly in the right upper and lower extremities, elevated levels of Mn in the blood and hair and high-intensity signals in the globus pallidus on T1-weighted MR images. Chelation therapy resulted in improvement of the myoclonic IVM and MRI abnormalities. This is the first report of Mn poisoning characterized by myoclonic IVM without parkinsonism.
authors.affiliation: Department of Neurology and Neurobiology of Aging, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Ono
authors.forename: Kiyonobu
authors.initials: K
authors.lastname: Komai
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002614:Chelating Agents / Q000627:therapeutic use; D004569:Electroencephalography; D004576:Electromyography; D005917:Globus Pallidus / Q000473:pathology; D006197:Hair / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese / Q000032:analysis / Q000097:blood; D020149:Manganese Poisoning / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009207:Myoclonus / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D016273:Occupational Exposure
chemical_list: D002614:Chelating Agents; D008345:Manganese