title: High serum concentrations of soluble E-selectin correlate with obesity but not fat distribution in patients with type 2 diabetes mellitus.
abstract: Serum concentrations of soluble adhesion molecules, eg, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin are elevated in patients with type 2 diabetes. However, little is known about the role of obesity or abnormal fat distribution in inducing upregulation of adhesion molecules. To investigate this issue, soluble ICAM-1, VCAM-1, and E-selectin levels were evaluated in 40 obese and 30 nonobese patients with type 2 diabetes. Both groups were matched for age, sex, and glycosylated hemoglobin (HbA(1c)) levels. Computed tomography (CT) was used to measure the abdominal subcutaneous and visceral fat areas. Soluble ICAM-1 and VCAM-1 levels did not differ significantly between obese and nonobese patients. However, serum concentrations of soluble E-selectin were significantly higher in obese than in nonobese patients (90 +/- 7 v 56 +/- 4 ng/mL, P <.01). Soluble E-selectin levels significantly correlated with body mass index, subcutaneous fat area, and visceral fat area (Rho = 0.48, 0.37, and 0.30, respectively). Stepwise multiple regression analysis showed that body mass index (F = 16.7), but not subcutaneous and visceral fat areas (F = 0.29 and 0.01, respectively), significantly and independently correlated with soluble E-selectin levels. Our results suggest that obesity may induce endothelial activation or increased shedding of cell surface E-selectin that leads to subsequent increase in soluble E-selectin levels. The high serum concentrations of E-selectin closely correlated with increased total fat volume, but not with regional fat distribution.
authors.affiliation: Department of Diabetes and Metabolism, Sasebo Chuo Hospital, Nagasaki, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sera
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Abe
authors.forename: Tan
authors.initials: T
authors.lastname: Tominaga
authors.forename: Kensaku
authors.initials: K
authors.lastname: Horikami
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirao
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ueki
authors.forename: Seibei
authors.initials: S
authors.lastname: Miyake
mesh_terms: D000005:Abdomen / Q000503:physiopathology; D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001786:Blood Glucose; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012995:Solubility; D014057:Tomography, X-Ray Computed; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D019040:E-Selectin; D006442:Glycated Hemoglobin; D018799:Intercellular Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1