title: A novel, multiple drug-resistant, serotype 24F strain of Streptococcus pneumoniae that caused meningitis in patients in Naples, Italy.
abstract: Three adult patients in Naples, Italy, had meningitis due to multiple drug-resistant serotype 24F Streptococcus pneumoniae isolates. The 3 isolates were genetically indistinguishable and shared pbp2b and pspA sequence types with previously characterized penicillin-resistant clones. This serotype 24F strain was found to be the same clonal type as a previously characterized, penicillin-resistant serotype 14 strain. The novel strain has probably arisen through transformation of a serotype 14 strain with type 24F capsular biosynthetic operon sequences.
authors.affiliation: Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanità, 00161 Rome, Italy. pantosti@iss.it
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pantosti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gherardi
authors.forename: Marco
authors.initials: M
authors.lastname: Conte
authors.forename: Francesco
authors.initials: F
authors.lastname: Faella
authors.forename: Giordano
authors.initials: G
authors.lastname: Dicuonzo
authors.forename: Bernard
authors.initials: B
authors.lastname: Beall
mesh_terms: D000368:Aged; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D016896:Treatment Outcome