Aspirin and lung cancer in women.
The association between aspirin use and lung cancer risk in women was examined in a case-control study nested in the New York University Women's Health Study, a large cohort in New York. Case subjects were all the 81 incident lung cancer cases who had provided information about aspirin use at enrollment and during the 1994-1996 follow up. Ten controls per case were randomly selected from among study participants who matched a case by age, menopausal status, and dates of enrollment and follow-up. Relative to no aspirin use, the odds ratio for lung cancer (all histological sub-types combined) among subjects who reported aspirin use three or more times per week for at least 6 months was 0.66 (95% confidence interval 0.34-1.28), after adjustment for smoking and education. A stronger inverse association was observed in analyses restricted to non-small cell lung cancer (adjusted odds ratio 0.39, 95% confidence interval 0.16-0.96). These results suggest that regular aspirin use might be inversely associated with risk of lung cancer in women, particularly the non-small cell sub-type.
Akhmedkhanov
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Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NBV-9E2, New York, NY 10016, USA. akhmea01@med.nyu.edu
Toniolo
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Zeleniuch-Jacquotte
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Koenig
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KL
Shore
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D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology* / Q000517:prevention & control*; D018288:Carcinoma, Small Cell / Q000453:epidemiology* / Q000517:prevention & control*; D016022:Case-Control Studies; D018890:Chemoprevention; D005260:Female; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D016017:Odds Ratio
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin