[The luteolytic action of prostaglandin F2-alpha analogues in guinea pig's ovary].
The role of prostaglandin at the level of the female genital system is multiple; they are involved in ovulation, luteolysis, contractility of the tube muscles, contraction of the gravid uterus, dilatation of the cervix. The synthetic analogous of the prostaglandin F2 alpha are utilized in a large area of treatments, for multiple purposes. The study was made on 2 lots with 10 non pregnant female guinea pig: the first lot was the witness lot and didn't receive any substance. The second lot received 100 micrograms/kg/day Isopropyl ester PGF2 alpha. The prostaglandin analogous produces vasodilating effects on the ovary blood vessels and luteolytic effects with the destruction of the ovarian follicles.
Indrei
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Facultatea de Medicină Stomatologică Disciplina de Anatomie şi Embriologie, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
Zamfir
C
C
Indrei
L L
LL
Mihalache
G
G
Păduraru
D
D
Nechifor
M
M
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D003341:Luteolysis / Q000187:drug effects*; D008186:Luteolytic Agents / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D013997:Time Factors
D008186:Luteolytic Agents; D015237:Dinoprost