Linkage analysis of Alzheimer disease with psychosis.
Although a portion of risk for late-onset AD (LOAD) is attributable to APOE, the search for other loci is ongoing. The authors hypothesize that psychotic symptoms with LOAD (LOAD+P) identify a potentially more etiologically homogeneous form of AD. Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity.
Bacanu
S A
SA
Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA.
Devlin
B
B
Chowdari
K V
KV
DeKosky
S T
ST
Nimgaonkar
V L
VL
Sweet
R A
RA
D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005192:Family Health; D006579:Heterozygote; D006801:Humans; D008126:Lod Score; D011618:Psychotic Disorders / Q000150:complications* / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E