title: glide/gcm: at the crossroads between neurons and glia.
abstract: Neurons and glia are generated by multipotent precursors. Recent studies indicate that the choice between the two fates depends on the combined activity of extracellular influences and factors that respond to precise spatial and temporal cues. Drosophila provides a simple genetic model to study the cellular and molecular mechanisms controlling fate choice, mode of precursor division and generation of cell diversity. Moreover, all glial precursors and glial-promoting activities have been identified in Drosophila, which provides us with a unique opportunity to dissect regulatory pathways controlling glial differentiation and specification.
authors.affiliation: Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC/CNRS/ULP/INSERM - BP 163 67404 ILLKIRCH, c.u. de Strasbourg, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Van De Bor
authors.forename: Angela
authors.initials: A
authors.lastname: Giangrande
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins; D008565:Membrane Proteins / Q000378:metabolism; D009420:Nervous System / Q000196:embryology; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D009479:Neuropeptides / Q000502:physiology*; D051880:Receptors, Notch; D013234:Stem Cells / Q000166:cytology*; D015534:Trans-Activators / Q000502:physiology*; D014157:Transcription Factors; D014714:Vertebrates / Q000196:embryology
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C102805:GCM protein, Drosophila; D008565:Membrane Proteins; C497759:N protein, Drosophila; D009479:Neuropeptides; D051880:Receptors, Notch; D015534:Trans-Activators; D014157:Transcription Factors