Exact solution of the Muñoz-Eaton model for protein folding.
A transfer-matrix formalism is introduced to evaluate exactly the partition function of the Muñoz-Eaton model, relating the folding kinetics of proteins of known structure to their thermodynamics and topology. This technique can be used for a generic protein, for any choice of the energy and entropy parameters, and in principle allows the model to be used as a first tool to characterize the dynamics of a protein of known native state and equilibrium population. Applications to a beta-hairpin and to protein CI-2, with comparisons to previous results, are also shown.
Bruscolini
Pierpaolo
P
Dipartimento di Fisica & INFM, Politecnico di Torino, c.so Duca degli Abruzzi 24, I-10129 Torino, Italy.
Pelizzola
Alessandro
A
D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D010940:Plant Proteins; D017510:Protein Folding; D017433:Protein Structure, Secondary; D013816:Thermodynamics
D010455:Peptides; D010940:Plant Proteins; C093336:chymotrypsin inhibitor 2