Mucosal tissue injury in cancer therapy. More than muscositis and mouthwash.
OBJECTIVE
The purpose of this article is as follows: 1) to describe the characteristics and scope of mucosal tissue injury associated with cancer treatment; 2) to discuss recent advances in related basic and clinical science; and 3) to articulate research needs and opportunities to be addressed through collaborative interdisciplinary research.


BACKGROUND
Mucosal tissue injury is both a direct and indirect consequence of cancer therapy, with manifestations that include damage and a number of other potentially serious sequelae. Current research in mucosal tissue injury is focused on the biology, immunology, and genetics of mucosal injury; clinical problems; assessment and management; and processes and outcomes of care.


CONCLUSIONS
Results from these various areas of research enhance the understanding of the mechanisms of mucosal tissue injury, provide direction for the development of policy and for clinical practice, and help to define research needs and opportunities. Future research on the complex process of mucosal tissue injury will be interdisciplinary and will cross the boundaries among basic, translational, and clinical science.
McGuire
Deborah B
DB
Deborah B. McGuire, PhD, RN, FAAN, Associate Professor, University of Pennsylvania School of Nursing, Philadelphia,Pennsylvania 19104, USA.
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001424:Bacterial Infections / Q000150:complications; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D009061:Mouth Mucosa / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D009092:Mucous Membrane / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D010146:Pain / Q000503:physiopathology; D013280:Stomatitis / Q000209:etiology / Q000503:physiopathology; D014777:Virus Diseases / Q000150:complications
D000970:Antineoplastic Agents