Obstructive uropathy: an important cause of chronic renal failure in children.
Care of individuals with renal failure continues to impose a tremendous burden on our national health care budget. Chronic renal failure is the final common denominator of a multiplicity of pathologic processes, some of which progress silently over years. Of these, obstructive uropathy is a prominent cause of kidney failure, accounting for 16.5% of all pediatric renal transplants in 1997. The pathophysiology of obstructive uropathy is reviewed as the basis for a differential diagnosis. In view of the significant role played by obstructive uropathy in the development of renal failure, early and definitive treatment of this clinical entity is imperative.
Roth
Karl S
KS
Department of Pediatrics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond 23229, USA.
Koo
Harry P
HP
Spottswood
Stephanie E
SE
Chan
James C M
JC
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D014551:Urinary Tract / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology*; D014570:Urologic Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*