title: Different outcomes of vertical transmission of hepatitis C virus in a twin pregnancy.
abstract: The risk of vertical transmission of hepatitis C virus (HCV) from mother to infant has been well documented, but the exact mode of transmission is still unclear. In a set of monochorionic diamniotic monozygous twins, only the second baby was infected with HCV from the mother who was positive for serum HCV-RNA. The babies had an uncomplicated vaginal delivery 3 min apart and they were both bottle fed from the outset. The second baby developed clinical hepatitis that persisted to 30 months follow up. The intrauterine environment should have been identical for these twins, and therefore, the maternal HCV factors, including viral load are not the sole determining factors for mother-to-infant transmission of HCV.
authors.affiliation: Department of Pediatrics, National Defense Medical College, Saitama, Japan. inui19@me.ndmc.ac.jp
authors.forename: Ayano
authors.initials: A
authors.lastname: Inui
authors.forename: Tomoo
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sogo
authors.forename: Haruki
authors.initials: H
authors.lastname: Komatsu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Isozaki
authors.forename: Isao
authors.initials: I
authors.lastname: Sekine
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D005260:Female; D006526:Hepatitis C / Q000097:blood / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011272:Pregnancy, Multiple; D013997:Time Factors; D014430:Twins, Monozygotic
chemical_list: D000410:Alanine Transaminase