Antiestrogenic regulation of transforming growth factor beta receptors I and II in human breast cancer cells.
To obtain more information about the interactions between antiestrogens and transforming growth factor beta (TGF-beta) signaling, we analyzed the influence of different types of antiestrogens on the expression of TGF-beta receptors I (TbetaRI) and II (TbetaRII). Our results show that antiestrogens selectively induce TbetaRII but not TbetaRI mRNA.
Buck
M
M
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and Robert Bosch Hospital, Department of Clinical Chemistry, 70376 Stuttgart, Germany. mariam.buck@ikp-stuttgart.de
von der Fecht
J
J
Knabbe
C
C
D001943:Breast Neoplasms / Q000378:metabolism*; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D006801:Humans; D017346:Protein Serine-Threonine Kinases; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
D020847:Estrogen Receptor Modulators; D012333:RNA, Messenger; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II