Malignant melanoma of the anorectum: report of four cases.
Four cases of anorectal malignant melanoma are reported in this paper. All patients underwent an abdominoperineal resection with lymph node dissection for a curative operation and received postoperative chemotherapy with dacarbazine, ranimustine, and vincristine, either with or without interferon-beta. One of these patients has been observed for more than 6 years postoperatively without any evidence of recurrence. The other three patients had advanced diseases at the time of diagnosis, and died within 3 years after operation. The prognosis of anorectal malignant melanoma is considered to be directly related to tumor size and depth. Therefore, a staging system and treatments based on the tumor size and depth (or thickness) are needed.
Fukui
Rika
R
First Department of Surgery, Sapporo Medical University School of Medicine, Japan.
Hata
Fumitake
F
Yasoshima
Takahiro
T
Honma
Toshio
T
Nomura
Hiroki
H
Sasaki
Kenichi
K
Nishimori
Hidefumi
H
Sasaki
Kazunori
K
Kutomi
Goro
G
Ohno
Keisuke
K
Oikawa
Ikuo
I
Sasaki
Kazuaki
K
Tarumi
Ken
K
Ishiyama
Yuuji
Y
Kobayashi
Kenji
K
Yamamoto
Naoya
N
Hirata
Koichi
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*