title: A new diterpene from Tanaecium jaroba.
abstract: One new diterpene, 2 alpha-hydroxy-12beta-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COSY, HMQC, HMBC, ROESY) and their antiplasmodial activities were evaluated in vitro against Plasmodium falciparum.
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Mitaine-Offer
authors.forename: Michel
authors.initials: M
authors.lastname: Sauvain
authors.forename: Eric
authors.initials: E
authors.lastname: Deharo
authors.forename: Victoria
authors.initials: V
authors.lastname: Muñoz
authors.forename: Monique
authors.initials: M
authors.lastname: Zèches-Hanrot
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D029402:Bignoniaceae; D001838:Bolivia; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: C465104:2-hydroxy-12-hydroxy-isopimara-8(14), 15-diene; D000962:Antimalarials; D004224:Diterpenes; D010936:Plant Extracts