Induction of complete remission of advanced stage mycosis fungoides by allogeneic hematopoietic stem cell transplantation.
Advanced mycosis fungoides (MF) is incurable with conventional treatments. High-dose chemoradiotherapy with autologous bone marrow transplantation has induced remissions in a small number of patients with MF, but this modality is limited by a high relapse rate. We report induction of complete remission in a 37-year-old woman with rapidly progressive stage IV MF with allogeneic stem cell transplantation (Allo SCT). She remains in continuous complete remission 2 years after transplant. Allo SCT for MF is theoretically attractive, because there is no contamination of the graft by malignant cells, and because of the possibility of graft-versus-tumor effect. Although the results in this patient are encouraging, more patients and longer follow-up are needed to define the usefulness of Allo SCT in the treatment of MF.
Masood
Nehal
N
Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA 98109-1023, USA.
Russell
Kenneth J
KJ
Olerud
John E
JE
Sabath
Daniel E
DE
Sale
George E
GE
Doney
Kristine C
KC
Flowers
Mary E D
ME
Fefer
Alexander
A
Thompson
John A
JA
D000328:Adult; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry; D009182:Mycosis Fungoides / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D009367:Neoplasm Staging; D012074:Remission Induction; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000379:methods