title: [The signalling cascade of fertilization].
abstract: The early event of fertilization-induced egg activation is a mobilization of intracellular Ca2+ that originates from the sperm entry point and spreads through the entire egg cytoplasm. Recently, this process has been established to require the sequential activation of Src family kinases, phospholipase C gamma, and inositoltrisphosphate receptor of endoplasmic reticulum. This review summarizes recent findings concerning the signalling pathway of fertilization from sperm-egg interaction to the Ca2+ release with emphasis on the role of tyrosine kinases in the egg activation.
authors.affiliation: A. A. Uktomsky Physiological Research Institute, St. Petersburg State University. tokmak@gsc.riken.go.ip
authors.forename: A A
authors.initials: AA
authors.lastname: Tokmakov
authors.forename: K I
authors.initials: KI
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Fukami
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005306:Fertilization / Q000502:physiology*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007527:Isoenzymes / Q000378:metabolism; D010063:Ovum / Q000378:metabolism*; D051966:Phospholipase C gamma; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007527:Isoenzymes; D018160:Receptors, Cytoplasmic and Nuclear; D019061:src-Family Kinases; D010738:Type C Phospholipases; D051966:Phospholipase C gamma; D002118:Calcium