title: [Physiological and pathological roles of apoptosis].
abstract: An understanding of the cellular events leading to apoptosis is important for the design of new chemotherapeutic agents directed against the types of leukemias and lymphomas that are resistant to currently used chemotherapeutic protocols. Malignant cell proliferation and accumulation depend on an imbalance between the rate of cell production and the rate of cell death. Apoptosis has been demonstrated to be involved not only in the regulation of normal tissues but also in the development and control of tumour cells. The relationship between oncogenes, apoptosis and growth factors is very important in determining prognosis when analysing the potential benefits of different treatment regimens.
authors.affiliation: Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
authors.forename: O M
authors.initials: OM
authors.lastname: Vasiliu
authors.forename: L M
authors.initials: LM
authors.lastname: Goga
authors.forename: C E
authors.initials: CE
authors.lastname: Cotrutz
authors.forename: C
authors.initials: C
authors.lastname: Cotrutz
authors.forename: C R
authors.initials: CR
authors.lastname: Ionescu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019014:fas Receptor / Q000276:immunology
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor