title: Age-related change of calbindin D-28k immunoreactive neurons in the rat main olfactory bulb.
abstract: We examined the aged-related changes of calbindin D-28k (CB)-immunoreactive (IR) neurons in the rat main olfactory bulb (MOB). The localization of CB-IR neurons was found to be almost entirely restricted to the glomerular layer. However, a few CB-IR neurons were observed in the granular layer. Prior to the 6th postnatal month (PM 6), the CB-IR neurons had long processes, and the population of CB-IR neurons had increased significantly compared to PM 12 and 24. At PM 12, CB-IR neurons showed a tendency to be smaller and have fewer dendrites than at guess. This phenomenon became remarkable at PM 24. The distinct reduction of CB-IR dendrites in glomeruli may be due to age-related functional restrictions. Increased calcium levels in the MOB neurons may be induced to allow cytotoxic event detection in the MOB neurons, and unbalanced Ca(2+)/Mg(2+)-ATPase may also induce aging-related MOB morphological changes.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea.
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Jae Chul
authors.initials: JC
authors.lastname: Lee
authors.forename: In Se
authors.initials: IS
authors.lastname: Lee
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Young Gil
authors.initials: YG
authors.lastname: Jeong
authors.forename: Jun-Gyo
authors.initials: JG
authors.lastname: Seo
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Oh
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D064026:Calbindins; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism*; D009830:Olfactory Bulb / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*
chemical_list: D064026:Calbindins; D064030:S100 Calcium Binding Protein G