Mathematical model of a variable aperture mitral valve.
Previous models of pressure and flow waveforms during diastolic ventricular filling by the Waite et al. [2] described mitral valve behavior by a constant effective valve area and a constant valve impedance. A model to describe the opening process of the mitral valve was developed. The model is based on second-order dynamics and Bernoulli's equation. The earlier lumped variable model for diastolic filling was modified to reflect a variable mitral valve aperture. The combined model was calibrated using pressure and flow waveforms from porcine experiments and artificial transmitral pressure gradient waveforms. A comparison between the results of the combined model and the earlier fixed aperture model shows better agreement of experimental and simulated transmitral flow waveform in the combined model.
Franck
Christoph Florian
CF
Department of Applied Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA.
Waite
Lee
L
D017097:Electric Impedance; D006439:Hemodynamics; D008943:Mitral Valve / Q000502:physiology*; D008955:Models, Cardiovascular