title: Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response.
abstract: The molecular bases of Mycobacterium tuberculosis pathogenicity remain unclear. We report here how M. tuberculosis mannosylated lipoarabinomannans contribute to the survival of bacilli in the human reservoir by (i) inhibiting IL-12 production by macrophages and dendritic cells and (ii) modulating M. tuberculosis-induced macrophage apoptosis.
authors.affiliation: Institut de Pharmacologie et de Biologie Structurale, CNRS, 205 route de Narbonne, Toulouse, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Nigou
authors.forename: Martine
authors.initials: M
authors.lastname: Gilleron
authors.forename: Mauricio
authors.initials: M
authors.lastname: Rojas
authors.forename: Luis F
authors.initials: LF
authors.lastname: García
authors.forename: Martin
authors.initials: M
authors.lastname: Thurnher
authors.forename: Germain
authors.initials: G
authors.lastname: Puzo
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D017209:Apoptosis; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D016207:Cytokines; D008070:Lipopolysaccharides; D011956:Receptors, Cell Surface; C050016:lipoarabinomannan