title: HLA-DRB1*15 and pediatric aplastic anemia.
abstract: We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.
authors.forename: Fatma S
authors.initials: FS
authors.lastname: Oguz
authors.forename: Nevin
authors.initials: N
authors.lastname: Yalman
authors.forename: Ali Sarper
authors.initials: AS
authors.lastname: Diler
authors.forename: Rusdu
authors.initials: R
authors.lastname: Oguz
authors.forename: Sema
authors.initials: S
authors.lastname: Anak
authors.forename: Mehmet Tevfik
authors.initials: MT
authors.lastname: Dorak
mesh_terms: D000741:Anemia, Aplastic / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002648:Child; D006684:HLA-DR Antigens / Q000097:blood*; D059811:HLA-DRB1 Chains; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D015415:Biomarkers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D007166:Immunosuppressive Agents