Somatic glypican 3 (GPC3) mutations in Wilms' tumour.
Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development.
White
G R M
GR
Cancer Research UK Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.
Kelsey
A M
AM
Varley
J M
JM
Birch
J M
JM
D017931:DNA Primers / Q000737:chemistry; D053673:Glypicans; D019812:Heparan Sulfate Proteoglycans / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D009396:Wilms Tumor / Q000235:genetics*
D017931:DNA Primers; D053673:Glypicans; D019812:Heparan Sulfate Proteoglycans