Cancer genomics.
The draft human genome sequence and the dissemination of high throughput technology provides opportunities for systematic analysis of cancer cells. Genome-wide mutation screens, high resolution analysis of chromosomal abberations and expression profiling all give comprehensive views of genetic alterations in cancer cells. From these analyses will come a complete list of the genetic changes that drive malignant transformation and of the therapeutic targets that may be exploited for clinical benefit.
Weber
Barbara L
BL
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA. weberb@mail.med.upenn.edu
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D014170:Transformation, Genetic