Elevated serum vascular endothelial growth factor levels in patients with polycythemia vera and thrombotic complications.
Vascular endothelial growth factor (VEGF) induces platelet activation in a thrombin-dependent manner. We tested the serum VEGF levels in patients with polycythemia vera (PV) and found a significant correlation between increased VEGF and thrombosis. These findings suggest that high VEGF levels might contribute to the occurrence of thrombosis in this hematologic malignancy.
Cacciola
Rossella R
RR
Di Francesco
Ernesto
E
Giustolisi
Rosario
R
Cacciola
Emma
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D016228:Endothelial Growth Factors / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008222:Lymphokines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000097:blood / Q000150:complications*; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000209:etiology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors