title: NMR difference probe: a dual-coil probe for NMR difference spectroscopy.
abstract: A unique probe designed to acquire nuclear magnetic resonance difference spectra of two samples is presented. The NMR Difference Probe contains two sample coils in a resonant circuit that switches between parallel excitation and serial acquisition to cancel common signals such as solvent peaks and impurities. Two samples containing a common analyte, acetonitrile, were used to demonstrate signal cancellation in a difference spectrum collected with a single pulse experiment. The cancellation was over 96% effective. The approach described has applications in the areas of solvent subtraction and spectral simplification.
authors.affiliation: H. C. Brown Laboratory, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393, USA.
authors.forename: Megan A
authors.initials: MA
authors.lastname: Macnaughtan
authors.forename: Ting
authors.initials: T
authors.lastname: Hou
authors.forename: Ernesto
authors.initials: E
authors.lastname: MacNamara
authors.forename: Robert E
authors.initials: RE
authors.lastname: Santini
authors.forename: Daniel
authors.initials: D
authors.lastname: Raftery
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D012815:Signal Processing, Computer-Assisted