Acute thrombotic obstruction of mitral valve prosthesis: low protein C level.
A 51-year-old female underwent redo mitral valve replacement with a pericardial bioprosthesis because of acute thrombotic obstruction of a mechanical valve, in spite of adequate anticoagulation with warfarin. Her protein C level was 24% of the normal value and protein S was reduced to 54% of normal.
Ohata
Toshihiro
T
Department of Cardiovascular Surgery, Osaka Police Hospital, Osaka, Japan. tohata@aol.com
Sakakibara
Tetsuo
T
Takano
Hiroshi
H
Ishizaka
Toru
T
D000208:Acute Disease; D000925:Anticoagulants / Q000627:therapeutic use; D001705:Bioprosthesis; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011486:Protein C / Q000032:analysis*; D012008:Recurrence; D012086:Reoperation; D012214:Rheumatic Heart Disease / Q000097:blood / Q000601:surgery*; D013923:Thromboembolism / Q000209:etiology* / Q000517:prevention & control; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D011486:Protein C; D014859:Warfarin