title: Systemic amyloidosis involving the diaphragm and acute massive hydrothorax during peritoneal dialysis.
abstract: Hydrothorax secondary to trans-diaphragmatic fluid leakage through a peritoneo-pleural communication is an occasional, potentially serious complication of peritoneal dialysis. The etiology of this condition is not clear, being thought to be due either to congenital or acquired diaphragmatic fenestrations or acquired scarcity of muscle fibers in the tendinous part of the diaphragm which are compounded by increased intra-abdominal pressure during the dwell period of peritoneal dialysis. We report a 54-year-old woman who developed irreversible acute renal failure from adjuvant chemotherapy for ovarian cancer previously resected surgically. Three days after the onset of continuous ambulatory peritoneal dialysis, she developed acute respiratory distress associated with a massive right hydrothorax secondary to a peritoneo-pleural communication demonstrated by scintigraphy. At autopsy 2 weeks later, systemic amyloidosis was surprisingly found and histologic examination of the right hemidiaphragm showed the presence of amyloid, among sparse muscle fibers. This is the first case report of a distinct pathological process, i.e. amyloidosis, involving the diaphragm associated with a peritoneo-pleural communication causing massive hydrothorax at the onset of peritoneal dialysis.
authors.affiliation: Department of Medicine, Montreal General Hospital, QC, Canada. raymonde.gagnon@muhc.mcgill.ca
authors.forename: R F
authors.initials: RF
authors.lastname: Gagnon
authors.forename: M
authors.initials: M
authors.lastname: Thirlweil
authors.forename: A
authors.initials: A
authors.lastname: Arzoumanian
authors.forename: A
authors.initials: A
authors.lastname: Mehio
mesh_terms: D000208:Acute Disease; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003964:Diaphragm / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D006876:Hydrothorax / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011859:Radiography; D012720:Severity of Illness Index