title: Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
abstract: Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides. PON1 has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192. We have examined these two aminoacidic changes in 579 people aged 20 to 65 years old, and 308 centenarians. We found that the percentage of carriers of the B allele at codon 192 (B+ individuals) is higher in centenarians than in controls (0.539 vs 0.447), moreover we found that among the B+ individuals, the phenomenon was due to an increase of people carrying M alleles at codon 55 locus. In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age.
authors.affiliation: Department of Experimental Pathology, Bologna University, Bologna, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Bonafè
authors.forename: Francesca
authors.initials: F
authors.lastname: Marchegiani
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cardelli
authors.forename: Fabiola
authors.initials: F
authors.lastname: Olivieri
authors.forename: Luca
authors.initials: L
authors.lastname: Cavallone
authors.forename: Simona
authors.initials: S
authors.lastname: Giovagnetti
authors.forename: Carlo
authors.initials: C
authors.lastname: Pieri
authors.forename: Maurizio
authors.initials: M
authors.lastname: Marra
authors.forename: Roberto
authors.initials: R
authors.lastname: Antonicelli
authors.forename: Leonarda
authors.initials: L
authors.lastname: Troiano
authors.forename: Paola
authors.initials: P
authors.lastname: Gueresi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Passeri
authors.forename: Maurizio
authors.initials: M
authors.lastname: Berardelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.forename: Michelangela
authors.initials: M
authors.lastname: Barbieri
authors.forename: Silvia
authors.initials: S
authors.lastname: Tesei
authors.forename: Rosmarie
authors.initials: R
authors.lastname: Lisa
authors.forename: Giovanna
authors.initials: G
authors.lastname: De Benedictis
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D019943:Amino Acid Substitution; D001120:Arginine; D043303:Aryldialkylphosphatase; D004950:Esterases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male
chemical_list: D001120:Arginine; D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human