title: Induction of complete remission of advanced stage mycosis fungoides by allogeneic hematopoietic stem cell transplantation.
abstract: Advanced mycosis fungoides (MF) is incurable with conventional treatments. High-dose chemoradiotherapy with autologous bone marrow transplantation has induced remissions in a small number of patients with MF, but this modality is limited by a high relapse rate. We report induction of complete remission in a 37-year-old woman with rapidly progressive stage IV MF with allogeneic stem cell transplantation (Allo SCT). She remains in continuous complete remission 2 years after transplant. Allo SCT for MF is theoretically attractive, because there is no contamination of the graft by malignant cells, and because of the possibility of graft-versus-tumor effect. Although the results in this patient are encouraging, more patients and longer follow-up are needed to define the usefulness of Allo SCT in the treatment of MF.
authors.affiliation: Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA 98109-1023, USA.
authors.forename: Nehal
authors.initials: N
authors.lastname: Masood
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Russell
authors.forename: John E
authors.initials: JE
authors.lastname: Olerud
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Sabath
authors.forename: George E
authors.initials: GE
authors.lastname: Sale
authors.forename: Kristine C
authors.initials: KC
authors.lastname: Doney
authors.forename: Mary E D
authors.initials: ME
authors.lastname: Flowers
authors.forename: Alexander
authors.initials: A
authors.lastname: Fefer
authors.forename: John A
authors.initials: JA
authors.lastname: Thompson
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry; D009182:Mycosis Fungoides / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D009367:Neoplasm Staging; D012074:Remission Induction; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000379:methods