Antiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annua.
Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.
Foglio
Mary Ann
MA
Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas da Universidade Estadual de Campinas (CPQBA/UNICAMP), Campinas, SP, Brazil. foglioma@cpqba.unicamp.br
Dias
Patrícia Corrêa
PC
Antônio
Marcia Aparecida
MA
Possenti
Ana
A
Rodrigues
Rodney Alexandre Ferreira
RA
da Silva
Erica Ferreira
EF
Rehder
Vera Lúcia Garcia
VL
de Carvalho
João Ernesto
JE
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D037621:Artemisinins; D019659:Asteraceae; D002229:Carbenoxolone / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000008:administration & dosage; D007213:Indomethacin / Q000008:administration & dosage; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D037621:Artemisinins; D010936:Plant Extracts; D012717:Sesquiterpenes; C465079:deoxyartemisinin 3; D000431:Ethanol; C055261:deoxyartemisinin; D002927:Cimetidine; C031327:artemisinin; D002229:Carbenoxolone; D007213:Indomethacin