[Role of chemokine receptors in allergic inflammation and new potential of treatment of bronchial asthma].
The recruitment of T lymphocytes into pulmonary tissue is a critical component of the host response to infections. Migration of T cells into the lung also orchestrates inflammation, tissue injury and remodelling of tissue architecture associated with the principal chronic inflammatory pulmonary diseases such as asthma. Chemotactic cytokines, named chemokines, play a major role in regulating localization of Th2 cells and other leukocytes into the lung during an asthmatic attack. Various proinflammatory functions have been ascribed to chemokines going from chemotaxis, activation and degranulation of distinct leukocyte subsets to remodelling of inflammed pulmonary tissue. This paper focuses on recent data either from clinical observations or animal models that have highlighted the importance of chemokines in pulmonary allergic inflammation. The recent advances in this field may now lead to the development of novel therapies for the allergic pulmonary diseases.
D'Ambrosio
Daniele
D
BioXell S.p.A. Via Olgettina, 58 20132 Milano. daniele.dambrosio@bioxell.com
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology*; D018925:Chemokines / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation; D007962:Leukocytes / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology; D019707:Receptors, Chemokine / Q000276:immunology*
D018925:Chemokines; D019707:Receptors, Chemokine