title: Increased parasiticide activity against Trichinella spiralis newborn larvae during pregnancy.
abstract: To evaluate whether pregnancy has a synergetic effect on the host's immune response against Trichinella spiralis infection, immunological and parasitological parameters relating to the infection were assessed in pregnant rats and compared to those observed in virgin infected rats. The muscle parasite load was lower in pregnant infected rats but no differences were found in the intestinal worm burdens or the fecundity of female worms. The ability of sera to mediate death in newborn larvae (NBL) in an antibody-dependent cell cytotoxicity assay was higher for pregnant rats, even in the absence of specific anti-NBL antibodies. High levels of total and anti-NBL IgE were found in both groups, however, these levels were higher in the group of pregnant infected animals. No differences were found in anti-NBL IgGAM titers, nevertheless in some pregnant infected rats these antibodies were found earlier. No differences were found in peritoneal or blood eosinophil counts. Offspring born to infected dams were found to be infected. The results obtained in this model demonstrate that during pregnancy there is an enhanced helminthotoxic effect towards the NBL. Despite this immunoactivation, vertical transmission of the parasite is possible.
authors.affiliation: Department of Microbiology, Immunology and Biotechnology, University of Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina.
authors.forename: G G
authors.initials: GG
authors.lastname: Nuñez
authors.forename: T
authors.initials: T
authors.lastname: Gentile
authors.forename: M L
authors.initials: ML
authors.lastname: Calcagno
authors.forename: S M
authors.initials: SM
authors.lastname: Venturiello
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000633:toxicity*; D000909:Antibodies, Helminth / Q000097:blood; D004195:Disease Models, Animal; D004804:Eosinophils; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007814:Larva / Q000187:drug effects; D007958:Leukocyte Count; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction; D013997:Time Factors; D017160:Trichinella spiralis / Q000187:drug effects / Q000254:growth & development* / Q000472:pathogenicity; D014235:Trichinellosis / Q000097:blood / Q000276:immunology
chemical_list: D000871:Anthelmintics; D000909:Antibodies, Helminth; D007073:Immunoglobulin E