title: SIR2 family of NAD(+)-dependent protein deacetylases.
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Smith
authors.forename: Jose
authors.initials: J
authors.lastname: Avalos
authors.forename: Ivana
authors.initials: I
authors.lastname: Celic
authors.forename: Shabazz
authors.initials: S
authors.lastname: Muhammad
authors.forename: Cynthia
authors.initials: C
authors.lastname: Wolberger
authors.forename: Jef D
authors.initials: JD
authors.lastname: Boeke
mesh_terms: D000107:Acetylation; D000595:Amino Acid Sequence; D000818:Animals; D001105:Archaea / Q000201:enzymology; D002645:Chickens; D003001:Cloning, Molecular; D020868:Gene Silencing; D006655:Histone Deacetylases / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D005810:Multigene Family; D009243:NAD / Q000378:metabolism*; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins; D015534:Trans-Activators / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D006657:Histones; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D015534:Trans-Activators; D009243:NAD; C087778:SIR2 protein, S cerevisiae; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases