[Effect of chitosan membrane on tendon adhesion and healing].
OBJECTIVE
To investigate the effects of chitosan membrane on tendon adhesion and healing and obtain experimental data for clinical use in preventing postoperative tendon adhesion.


METHODS
The long flexor tendon of 55 adult legborn hens were cut and sutured encapsulated by chitosan membrane. Movement and anti-tension capability of tendon were assessed at 2, 4, 6, 8 and 10 weeks after operation by SWD-10 type tendon stretcher. Tendon healing and adhesion were observed with light microscope.


RESULTS
Tendon healing could be effected by chitosan membrane within 4 weeks, and tendon anti-tension strength was increased after 4 weeks.


CONCLUSIONS
Chitiosan membrane possesses the following characteristics: no side effects, good permeability, resolvable, absorbable and selective inhibition the growth of fibroblast. It is a desirable biological material to prevent tendon adhesion.
Zhang
H
H
Orthopedic Surgery Department, Zhujiang Hospital of First Military Medical University, Guangzhou, Guangdong, P. R. China 510282.
Sheng
Z J
ZJ
Hou
C L
CL
D000818:Animals; D002645:Chickens; D002686:Chitin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D048271:Chitosan; D005260:Female; D008567:Membranes, Artificial; D011897:Random Allocation; D013708:Tendon Injuries / Q000601:surgery*; D013710:Tendons; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects*
D008567:Membranes, Artificial; D002686:Chitin; D048271:Chitosan