title: Energetic parameter changes with mechanical ventilation in conjunction with BVAD assistance.
abstract: The aim was to assess the influence of a biventricular assist device (BVAD) on ventricular energetics parameters (external work, oxygen consumption, cardiac mechanical efficiency) for both ventricles, when mechanical ventilation was applied. The experiments were performed using a computer simulator of cardiovascular system (CARDIOSIM) after modelling a pathological state of the left ventricle (E(v)Left = 0. 9 mmHg cm(-3) and increasing pulmonary resistance (Rap = 0.3 mmHg cm(-3 s). The effect of mechanical ventilation was mean intrathoracic pressure changes from 0 to +5 mmHg. This simulation showed that application of BVAD for both ventricles reduces external work and that this effect is stressed by positive intrathoracic pressure, reduces cardiac mechanical efficiency that is quite insensitive to intrathoracic pressure and increases oxygen consumption, which is reduced by positive intrathoracic pressure. The increase of potential energy at the onset of BVAD evidences a rightwards shift of ventricular work cycle (unloading of the ventricles). In general, positive intrathoracic pressure during BVAD assistance adversely affects ventricular energetics.
authors.affiliation: Istituto di Tecnologie Biomediche CNR, Reparto di Ingegneria Cardiovasculare, Rome, Italy. dela@itbm.rm.cnr.it
authors.forename: C
authors.initials: C
authors.lastname: De Lazzari
authors.forename: M
authors.initials: M
authors.lastname: Darowski
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: F
authors.initials: F
authors.lastname: Clemente
authors.forename: M
authors.initials: M
authors.lastname: Guaragno
mesh_terms: D001698:Biomedical Engineering; D003198:Computer Simulation; D004734:Energy Metabolism; D006321:Heart / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D011312:Pressure; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods; D013909:Thorax