Tobacco smoke exposure and bombesin-like peptides in guinea pigs.
Bombesin-like peptides (BLPs) are associated with tobacco smoke (TS)-induced diseases. We sought to determine if acute TS exposure releases BLPs into the pulmonary circulation. Sensitized and non-sensitized guinea pigs were chronically exposed to TS or compressed air. Thereafter, the lungs were acutely challenged with TS while perfused. Perfusates were analyzed for BLPs. TS increased BLPs in non-sensitized guinea pigs. A separate study determined daily bombesin exposure increased lung cell counts but not airway hyperresponsivensess. TS exposure releases BLPs into the pulmonary circulation but can be modified by host factors and bombesin itself does not induce airway hyperresponsiveness.
Bergren
Dale R
DR
Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA. dbergren@creighton.edu
D000280:Administration, Inhalation; D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001835:Body Weight; D001839:Bombesin / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D001992:Bronchoalveolar Lavage Fluid; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology; D002452:Cell Count; D019886:Gastrin-Releasing Peptide / Q000097:blood; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply* / Q000166:cytology / Q000187:drug effects / Q000503:physiopathology; D010047:Ovalbumin / Q000008:administration & dosage / Q000494:pharmacology; D010477:Perfusion; D010993:Plethysmography, Whole Body; D011863:Radioimmunoassay; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000503:physiopathology; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology; D012907:Smoking / Q000097:blood* / Q000503:physiopathology*; D014132:Trachea / Q000502:physiology
D000336:Aerosols; D012701:Serotonin; D019886:Gastrin-Releasing Peptide; D006632:Histamine; D010047:Ovalbumin; D001839:Bombesin; D002211:Capsaicin