title: Bilateral angiosarcoma of the breast after conservative treatment of bilateral invasive carcinoma: genetic predisposition?
abstract: OBJECTIVE
  In view of the increasing application of breast-conserving therapy (BCT) for early breast cancer during the last decades, the number of BCT-associated angiosarcomas is likely to increase. Their aetiology is not completely clear. The aim of this study was to examine the potential role of genetic predisposition for development of this rare tumour.
  
  
  METHODS
  The authors report on a case of consecutive bilateral development of angiosarcoma of the breast 6 and 12 years after BCT for bilateral invasive breast carcinoma. The literature was reviewed and the potential role of genetic predisposition was examined.
  
  
  RESULTS
  Such a case of bilateral BCT-induced breast angiosarcoma has not been previously reported in the international literature. The change on development of such a tumour bilaterally is 0.25-2.6 per million women who underwent bilaterally BCT with radiotherapy for invasive carcinoma. The case history and the literature review suggest that gene mutations are likely to play a role in development of post-radiation angiosarcoma of the breast.
  
  
  CONCLUSIONS
  It is assumed that genetic predisposition may play a role in the development of angiosarcoma after BCT. When such a predisposition is known, one might decide to avoid BCT in favour of mastectomy.
authors.affiliation: Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: de Bree
authors.forename: F
authors.initials: F
authors.lastname: van Coevorden
authors.forename: J L
authors.initials: JL
authors.lastname: Peterse
authors.forename: N S
authors.initials: NS
authors.lastname: Russell
authors.forename: E J Th
authors.initials: EJ
authors.lastname: Rutgers
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006394:Hemangiosarcoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008327:Mammography; D015412:Mastectomy, Segmental / Q000009:adverse effects* / Q000379:methods; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D018570:Risk Assessment; D013997:Time Factors; D014057:Tomography, X-Ray Computed