title: Positional cloning of an obesity/diabetes susceptibility gene(s) on chromosome 11 in Pima Indians.
abstract: Prior results from our genomic scan in Pima Indians indicated an obesity locus in a region on chromosome 11q23-24 that was also linked to diabetes. Bivariate linkage analysis for the combined phenotype "diabesity" gave the strongest evidence for linkage (LOD = 5.2). Our aim is to positionally clone the gene(s) responsible for the linkage. Linkage disequilibrium mapping is being used to narrow the chromosomal region. Single nucleotide polymorphisms (SNPs) are being systematically identified and genotyped at 50-kb intervals across the region of linkage. To date, 455 SNPs have been genotyped in 1229 Pimas. A region containing a cluster of SNPs strongly associated with BMI and a second region, approximately 2 Mb telomeric, containing a cluster of SNPs associated with diabetes have been preliminarily identified.
authors.affiliation: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA. lbaier@phx.niddk.nih.gov
authors.forename: Leslie
authors.initials: L
authors.lastname: Baier
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacs
authors.forename: Christopher
authors.initials: C
authors.lastname: Wiedrich
authors.forename: Kimberly
authors.initials: K
authors.lastname: Cray
authors.forename: Amy
authors.initials: A
authors.lastname: Schemidt
authors.forename: Gong-Qing
authors.initials: GQ
authors.lastname: Shen
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Sutherland
authors.forename: Pamela
authors.initials: P
authors.lastname: Thuillez
authors.forename: Yunhua Li
authors.initials: YL
authors.lastname: Muller
authors.forename: Michael
authors.initials: M
authors.lastname: Traurig
authors.forename: Clifton
authors.initials: C
authors.lastname: Bogardus
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D015810:Linkage Disequilibrium; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide