[Protective effects of ischemic preconditioning on ischemia reperfusion injuries of kidney: experimental studies].
We studied the serum levels of SOD and creatinine(Cr) of venous blood and changes in renal tissue structures under electromicroscope in the ischemia referfusion(I/R), the ischemic preconditioning(PC1, PC2, PC3), and the control groups in rabbits. The results were that the serum levels of SOD and Cr in the I/R group were obviously higher than that in the PC and control groups after one-hour ischemia and one-hour reperfusion(P < 0.001). There were no significant difference in Cr levels between the PC2 and control groups; there were significant degenerate and necrotic changes under the electromicroscope in renal tissues in the I/R group, but there were no significant change in the PC and control groups. The results suggest that PC plays a role in protecting the kidney from injury induced by ischemia and reperfusion.
Xie
J
J
Department of Urology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Xie
Z
Z
Zhang
S
S
Qi
F
F
D000818:Animals; D003404:Creatinine / Q000097:blood; D005260:Female; D019194:Ischemic Preconditioning; D007668:Kidney / Q000098:blood supply* / Q000648:ultrastructure; D008297:Male; D011817:Rabbits; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000097:blood
D003404:Creatinine; D013482:Superoxide Dismutase