[Clinical observation on ondansetron in preventing nausea and vomiting after cholecystectomy under abdominoscope].
OBJECTIVE
To evaluate the prophylactic effect of ondansetron on postoperative nausea and vomiting (PONV) of cholecystectomy under abdominoscope.


METHODS
Sixty patients, scheduled for selective cholecystectomy under abdominoscope, were randomly and double-blindly allocated to receive an intravenous bolus of either 0.9% NS 10 ml(Group placebo, n = 30) or 8 mg of ondansetron in 10 ml solution(Group ondansetron, n = 30), respectively.


RESULTS
The incidences of nausea and vomiting in ondansetron group(33.3% and 26.7%) were significantly lower than those in placebo group(73.3% and 66.7%) (P < 0.05). Administration of ondansetron had no obvious effect on the mean arterial pressure, SpO2, and respiratory frequency.


CONCLUSIONS
Ondansetron can be used effectively and safely to prevent PONV in cholecystectomy patients under abdominoscope.
Li
Y
Y
Department of Anesthesiology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Guo
Q
Q
Fu
D
D
D000932:Antiemetics / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D017294:Ondansetron / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000517:prevention & control*; D011184:Postoperative Period
D000932:Antiemetics; D017294:Ondansetron