title: Safety, tolerability and immunogenicity of low dose Haemophilus influenzae type b conjugated to the outer membrane protein complex of Neisseria meningitidis group B.
abstract: Infants vaccinated with three doses followed by a booster of either 1.0 microg of Haemophilus influenzae type b conjugated to the outer membrane protein complex of Neisseria meningitidis group B or H. influenzae 10-microg oligosaccharide vaccine conjugated to 25 microg mutant toxin (CRM197) isolated from Corynebacterium diphtheriae had protective antipolyribosylribitol phosphate concentrations.
authors.affiliation: Saint Louis University Health Sciences Center Division of Infectious Disease and Immunology, St Louis, MO, USA.
authors.forename: Edwin L
authors.initials: EL
authors.lastname: Anderson
authors.forename: Sharon
authors.initials: S
authors.lastname: Frey
authors.forename: Kathy
authors.initials: K
authors.lastname: Geldmacher
authors.forename: David
authors.initials: D
authors.lastname: Radley
authors.forename: Ann
authors.initials: A
authors.lastname: Lee
authors.forename: John
authors.initials: J
authors.lastname: Donnelly
authors.forename: Paul M
authors.initials: PM
authors.lastname: Mendelman
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Dargan
authors.forename: Karen M
authors.initials: KM
authors.lastname: Kaplan
mesh_terms: D000917:Antibody Formation; D001425:Bacterial Outer Membrane Proteins; D004305:Dose-Response Relationship, Drug; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology / Q000517:prevention & control*; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D019741:Haemophilus influenzae type b / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007223:Infant; D008297:Male; D009345:Neisseria meningitidis / Q000737:chemistry / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate