title: Manufacturing and characterization of 3-d hydroxyapatite bone tissue engineering scaffolds.
abstract: Internal architecture has a direct impact on the mechanical and biological behaviors of porous hydroxyapatite (HA) implants. However, traditional processing methods provide very minimal control in this regard. This paper reviews a novel processing technique developed in our laboratory for fabricating scaffolds with controlled internal architectures. The preliminary mechanical property and in vivo evaluation of these scaffolds are also presented.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. ctmin@engin.umich.edu
authors.forename: T-M G
authors.initials: TM
authors.lastname: Chu
authors.forename: S J
authors.initials: SJ
authors.lastname: Hollister
authors.forename: J W
authors.initials: JW
authors.lastname: Halloran
authors.forename: S E
authors.initials: SE
authors.lastname: Feinberg
authors.forename: D G
authors.initials: DG
authors.lastname: Orton
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000378:metabolism* / Q000502:physiology*; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D012984:Software; D013552:Swine; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite