Genetic approaches to the study of Toll-like receptor function.
The Toll-like receptor (TLR) family plays a role in sensing invading pathogens. Ten members have been reported to date, seven of which were found to recognize discrete bacterial components. Mouse models lacking each TLR and its signaling molecule are useful tools for the analysis of the innate immune system.
Takeuchi
Osamu
O
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka, Japan.
Akira
Shizuo
S
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D001419:Bacteria / Q000276:immunology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D018899:CpG Islands / Q000276:immunology; D029721:Drosophila Proteins; D005408:Flagellin / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology*; D007313:Insecta / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology*; D053594:Myeloid Differentiation Factor 88; D010944:Plants / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000276:immunology*; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors
D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation; D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors; D005408:Flagellin