title: Serum insulin-like growth factor 1 level and nutritional assessment in nondialytic patients with chronic renal failure.
abstract: OBJECTIVE
  In order to understand the nutritional status of nondialytic patients with chronic renal failure (CRF), nutritional assessment was made in 20 nondialytic patients (15 males and 5 females; mean age 43.7 +/- 15.1 years).
  
  
  METHODS
  Twenty CRF inpatients were selected for nutritional assessment, and 20 normal subjects served as controls. The serum insulin-like growth factor 1 (IGF-1) concentration was measured by ELISA. Serum albumin, prealbumin, and transferrin levels were also determined.
  
  
  RESULTS
  The mean IGF-I and transferrin levels in the CRF patients were significantly lower than those in normal subjects (IGF-1: 176.2 +/- 92.5 microg/l vs. 266.7 +/- 101.7 microg/l, p < 0.01; transferrin: 2.57 +/- 0.58 g/l vs. 3.18 +/- 0.27 g/l, p < 0.05). The IGF-1 levels in 7 patients with a serum albumin concentration <40.0 g/l were significantly lower than those in 13 patients with a serum albumin concentration >40.0 g/l (95.6 +/- 42.4 microg/l vs. 219.6 +/- 82.7 microg/l, p < 0.01). The IGF-1 levels in cases treated with alpha-ketoacid were higher than in those without alpha-ketoacid treatment. The IGF-1 levels were positively correlated with creatinine clearance (r = 0.7066, p < 0.01) and serum transferrin concentration (r = 0.5347, p < 0.05).
  
  
  CONCLUSIONS
  The fact that serum IGF-1 was correlated with serum transferrin and creatinine clearance suggests that IGF-1 may be a good indicator for assessing the nutritional status of CRF patients. The serum IGF-1 level in CRF patients is probably lower than that in normal subjects and could be improved by nutritional therapy.
authors.affiliation: Department of Nephrology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
authors.forename: Fangping
authors.initials: F
authors.lastname: Lu
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Falei
authors.initials: F
authors.lastname: Zheng
authors.forename: Zhaoquan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomino
mesh_terms: D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007651:Keto Acids / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011228:Prealbumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
chemical_list: D007651:Keto Acids; D011228:Prealbumin; D014168:Transferrin; D007334:Insulin-Like Growth Factor I