Mechanisms of TNF receptor-associated factor (TRAF) regulation in B lymphocytes.
A key component of signaling by members of the tumor necrosis factor receptor (TNF-R) family is interaction with the cytoplasmic adapter proteins known as TRAFs. Several proteins encoded by microbes also interact with TRAFs. A notable example is the CD40 receptor, expressed on antigen presenting cells and providing key activation signals in T cell-dependent B cell activation. CD40 signals to B cells are mimicked by a constitutively active viral protein produced by the Epstein-Barr virus. For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview.
Bishop
Gail A
GA
Department of Microbiology, 3-570 Bowen Science Building, The University of Iowa, Iowa City, IA 52242, USA. gail-bishop@uiowa.edu
Hostager
Bruce S
BS
Brown
Kevin D
KD
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D019013:CD40 Antigens / Q000378:metabolism; D008213:Lymphocyte Activation; D021962:Membrane Microdomains / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D011506:Proteins / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D015398:Signal Transduction; D014763:Viral Matrix Proteins / Q000494:pharmacology
D019013:CD40 Antigens; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D011506:Proteins; D018124:Receptors, Tumor Necrosis Factor; D014763:Viral Matrix Proteins