Understanding copper uptake at the molecular level.
Despite significant advances in our understanding of copper efflux mechanisms since the discovery and characterization of Cu-ATPase genes mutated in Menkes and Wilson diseases, little is known about how cells acquire this essential micronutrient. Recent studies on Ctr1 have illuminated how copper may be transported into mammalian cells.
Wessling-Resnick
Marianne
M
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D027682:Cation Transport Proteins; D003300:Copper / Q000378:metabolism*; D000079923:Copper Transporter 1; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008958:Models, Molecular
D027682:Cation Transport Proteins; D000079923:Copper Transporter 1; D008565:Membrane Proteins; C490079:SLC31A1 protein, human; C490077:Slc31a1 protein, mouse; D003300:Copper