[Effect of basic fibroblast growth factor on repairing transected sciatic nerve in rats].
OBJECTIVE
To investigate the effects of basic fibroblast growth factor(bFGF) on repairing transected sciatic nerves in rats.


METHODS
The animal models of the transected sciatic nerve of 40 SD rats were established, which divided into 4 groups: normal saline (NS) group, nerve growth factor (NGF) group, bFGF group and normal control group. The epineurium of the transected sciatic nerve was sutured under microscope, then bFGF or NGF was dropped into local sites and injected intramuscularly once a day for 30 days after operation. Functional repair for the transected sciatic nerves was studied by nerve conductive velocity (NCV) and sciatic nerve function index (SFI).


RESULTS
As a criterion, the level of the normal control group was regarded as zero, SFI of NS group, NGF group and bFGF group were -114.30 +/- 10.34, -70.50 +/- 11.01, -50.45 +/- 7.82 respectively at 1 month after operation, and they were -54.96 +/- 16.46, -35.21 +/- 10.80, -27.53 +/- 11.23 respectively in 3 months after operation. NCV of bFGF group was significantly faster than NS group and NGF group.


CONCLUSIONS
bFGF can significantly promote the functional repair of injured peripheral nerve, and its effects are better than NGF.
Hong
A
A
Bio-Engineering Institute, JiNan University, Guangzhou, Guangdong, P. R. China 510632.
Li
X K
XK
Fu
Z G
ZG
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D008297:Male; D020932:Nerve Growth Factor / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects*
D016222:Fibroblast Growth Factor 2; D020932:Nerve Growth Factor