title: Phosphinoferrocenylaminophosphines as novel and practical ligands for asymmetric catalysis.
abstract: [structure: see text] A new series of ligands with a novel phosphine-aminophosphine ligation design as depicted in structure 1 has been prepared on a ferrocenylethyl backbone. These BoPhoz ligands of structure 2 have afforded exceedingly high activity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of dehydro-alpha-amino acid derivatives, itaconic acids, and alpha-ketoesters. These air-stable ligands are readily prepared from cost-effective and non-pyrophoric intermediates.
authors.affiliation: Research Laboratories, Eastman Chemical Company, P.O. Box 1972, Kingsport, Tennessee 37662, USA. nwboaz@eastman.com
authors.forename: Neil W
authors.initials: NW
authors.lastname: Boaz
authors.forename: Sheryl D
authors.initials: SD
authors.lastname: Debenham
authors.forename: Elaine B
authors.initials: EB
authors.lastname: Mackenzie
authors.forename: Shannon E
authors.initials: SE
authors.lastname: Large