In vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum. The ether extract from aerial parts of the plant collected in São Tomé e Príncipe, demonstrated good antiplasmodial activity (IC 50 on FCA strain: 0.75 microg/ml). A bioassay guided fractionation of this extract led to the isolation of the known sesquiterpene lactone tagitinin C as an active component against Plasmodium (IC 50 on FCA strain: 0.33 microg/ml), but also possessing cytotoxic properties (IC 50 on HTC-116 cells: 0.706 microg/ml).
Goffin
Eric
E
Ziemons
Eric
E
De Mol
Patrick
P
de Madureira
Maria do Céu
Mdo C
Martins
Ana Paula
AP
da Cunha
Antonio Proença
AP
Philippe
Geneviève
G
Tits
Monique
M
Angenot
Luc
L
Frederich
Michel
M
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D019659:Asteraceae; D002738:Chloroquine / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes; C012565:tagitinin; D002738:Chloroquine