title: Vancomycin reaction during spinal anaesthesia.
abstract: A 77-year-old female received uneventful spinal anaesthesia for a total knee replacement. Upon the advice of the microbiologists and at the request of the orthopaedic surgeon, a vancomycin infusion was commenced prior to the application of the leg tourniquet. Five minutes later, having received only 40 mg of the antibiotic dose, she became unconscious and suffered severe cardiovascular collapse, from which she was resuscitated with intravenous ephedrine and adrenaline.
authors.affiliation: Department of Anaesthesia, The Queen Elizabeth Hospital, Woodville, South Australia.
authors.forename: B L
authors.initials: BL
authors.lastname: Duffy
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000209:etiology* / Q000628:therapy; D000775:Anesthesia, Spinal / Q000009:adverse effects* / Q000379:methods; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D019645:Arthroplasty, Replacement, Knee / Q000379:methods; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D011300:Preoperative Care; D018570:Risk Assessment; D014640:Vancomycin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014640:Vancomycin