Functional aspects of the Leishmania donovani lipophosphoglycan during macrophage infection.
The most abundant surface glycoconjugate of the Leishmania promastigotes is lipophosphoglycan, a glycosylphosphatidyl-inositol-anchored polymer of the repeating disaccharide-phosphate Gal(beta1,4)Manalpha1-PO4 unit. This complex molecule possesses properties that contribute to the ability of Leishmania to modulate macrophage signaling pathways during the initiation of infection.
Descoteaux
Albert
A
INRS-Institut Armand-Frappier, université du Québec, 531 des Prairies, Laval, QC, Canada. albert.descoteaux@iaf.uquebec.ca
Turco
Salvatore J
SJ
D000818:Animals; D002240:Carbohydrate Sequence; D006028:Glycosphingolipids / Q000737:chemistry / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D007893:Leishmania donovani / Q000276:immunology / Q000502:physiology; D007896:Leishmaniasis / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000469:parasitology*; D021962:Membrane Microdomains; D008969:Molecular Sequence Data; D010587:Phagocytosis; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction
D006028:Glycosphingolipids; D007375:Interleukin-1; D047428:Protein Kinase Inhibitors; C008290:lipophosphonoglycan; D011494:Protein Kinases