AVP(4-8) Enhances PKC and MAPK Activities in SK-N-SH Cells.
AVP(4-8), one of endogenous metabolite of argipressin(AVP) in brain, can enhance learning and memory. To understand further the molecular mechanism of its function, human neuroblastoma SK-N-SH cell line was chosen as a model to study its signal transduction pathway. Radioligand binding assay showed the existence of binding sites for AVP(4-8) on SK-N-SH cells. The activity of PKC and MAPK in SK cells was significantly enhanced by AVP(4-8), and the enhancement of PKC and MAPK was suppressed by ZDC(C)PR, an antagonist of AVP(4-8).
Zhen
Xiao-Guang
XG
Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. duyc@sunm.shcnc.ac.cn
Du
Yu-Cang
YC