title: Infusion of maintenance fluids with glucose (Veen 3G) is superior to maltose infusion (Actit) in the rate of energy utilization in rabbits.
abstract: In the present study, we examined the rates of urinary excretion of glucose and maltose after an infusion of maintenance fluid with glucose or maltose in adult rabbits. Three maintenance fluids (sugar-free, 5% glucose [Veen 3G] and 5% maltose [Actit]), which contained different sugars but were identical in electrolyte and acetate compositions and concentrations (Na: 45, K: 17, Mg: 5, Cl: 37, H2PO4: 10 and CH3COO: 20 mEq/l), were used in this study. In addition, the optimum infusion speed for maintenance therapy (10 ml/kg/h) was used. Animals were not given food or water during the 10-day period of administration. The body weights of the animals were measured every day. The concentrations of total protein, albumin, free fatty acids and glucose in the serum were measured. Urine samples for determination of glucose and maltose concentrations were collected from the 1st to 10th administrations. After infusion with 5% maltose, urinary maltose excretion decreased time-dependently, while that of glucose increased. This suggests that maltase activity time-dependently increases after infusion with maltose. In addition, total sugar was only minimally excreted into urine in the 5% glucose group compared with the 5% maltose group. Thus, the glucose infusion was superior to the maltose infusion in the rate of energy utilization. However, neither the loss of body weight nor the increase in concentration of free fatty acids in serum differed significantly among the 3 groups. In conclusion, infusion of maintenance fluid with 5% maltose results in the excretion of maltose and glucose into urine, since enzymatic hydrolysis of maltose to glucose is limited to that by maltase.
authors.affiliation: Department of Medical Development, Nikken Chemicals Co., Ltd., Tokyo, Japan. JDW06164@nifty.ne.jp
authors.forename: J
authors.initials: J
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Yamana
authors.forename: S
authors.initials: S
authors.lastname: Yanagida
authors.forename: S
authors.initials: S
authors.lastname: Ohtani
authors.forename: K
authors.initials: K
authors.lastname: Onodera
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D005440:Fluid Therapy; D005947:Glucose / Q000378:metabolism*; D007260:Infusion Pumps; D008297:Male; D008320:Maltose / Q000378:metabolism* / Q000652:urine; D011817:Rabbits
chemical_list: D008320:Maltose; D005947:Glucose