Reversible anti-fertility effect of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose content in rats.
Treatment of albino rats with a benzene extract of Ocimum sanctum leaves (250 mg/kg body weight) for 48 d decreased total sperm count, sperm motility, and forward velocity. The percentage of abnormal sperm increased in caudal epididymal fluid, and the fructose content decreased in the caudal plasma of the epididymis and the seminal vesicles. The results suggest that such effects are due to androgen deprivation, caused by the anti-androgenic property of O. sanctum leaves. The effect was reversible because all parameters returned to normal 2 wk after the withdrawal of treatment.
Ahmed
Mukhtar
M
Department of Post-Graduate Studies in Zoology, Karnatak University, Dharwad, India.
Ahamed
R Nazeer
RN
Aladakatti
R H
RH
Ghosesawar
M G
MG
D000818:Animals; D001554:Benzene / Q000737:chemistry; D004822:Epididymis / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005632:Fructose / Q000378:metabolism*; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D031339:Ocimum / Q000737:chemistry / Q000633:toxicity*; D009929:Organ Size; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012661:Semen / Q000187:drug effects / Q000378:metabolism; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000473:pathology
D010936:Plant Extracts; D005632:Fructose; D001554:Benzene