title: [Treatment of alopecia areata with diphencyprone].
abstract: Topic immunotherapy in alopecia areata consist in a mild contact dermatitis with help of a chemical substances, with a high potency of sensitization, such as dinytroclorbenzenul (DNCB), squaric acid dibutylester (SADBE) and diphencypronil (DPCP). Eight patients with alopecia areata, 3 with mild form and 5 with severe form was treated with DPCP in acetone solution. We have obtained a positive result in 3 cases (37.5%), one with total regrows and 2 with partial regrows and a negative result in 5 cases, 3 with partial regrows and loss of the hair in other areas and 2 cases with no response after 24 weeks. We consider this method like an alternative therapy in severe alopecia areata resistant at other treatments.
authors.affiliation: Centrul Medical Nicolina Iaşi, Universitatea de Medicină şi Farmacie Gr.T Popa Iaşi.
authors.forename: G
authors.initials: G
authors.lastname: Suditu
authors.forename: A
authors.initials: A
authors.lastname: Toma
authors.forename: M
authors.initials: M
authors.lastname: Voiculescu
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000188:drug therapy*; D003521:Cyclopropanes / Q000008:administration & dosage*; D003877:Dermatitis, Contact / Q000209:etiology; D005260:Female; D006197:Hair / Q000187:drug effects; D006801:Humans; D007114:Immunization / Q000379:methods; D008297:Male; D016896:Treatment Outcome
chemical_list: D003521:Cyclopropanes; C029402:diphenylcyclopropenone