Oral manifestations of patients with Marfan syndrome: a case-control study.
OBJECTIVE
The purpose of this study was to conduct a complete analysis of the oral abnormalities of patients with Marfan syndrome.


METHODS
Twenty three patients with Marfan syndrome and 69 healthy controls were studied. The subjects were screened for cariologic and periodontal alterations, as well as structural defects of enamel and dentin. Data analysis was performed by using the t test, the chi-square test, and regression models.


RESULTS
Patients aged 0 to 17 years were significantly at risk for caries. Local hypoplastic enamel spots were more frequent in Marfan syndrome and could be related to caries history of the deciduous dentition. Root deformity, abnormal pulp shape, and pulpal inclusions were a frequent finding in patients with Marfan syndrome. Calculus and gingival indices were significantly higher in the study group as well.


CONCLUSIONS
This study shows the importance of early diagnosis of oral anomalies and timely treatment of dental problems in Marfan syndrome. A series of therapeutic guidelines to be integrated in treatment strategies is proposed.
De Coster
P J A
PJ
Ghent University, Ghent, Belgium. peter.decoster@rug.ac.be
Martens
L C M
LC
De Paepe
A
A
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003728:Dental Calculus / Q000209:etiology; D003731:Dental Caries / Q000209:etiology; D003733:Dental Caries Susceptibility; D003743:Dental Enamel / Q000002:abnormalities; D003744:Dental Enamel Hypoplasia / Q000209:etiology; D003782:Dental Pulp / Q000002:abnormalities; D003804:Dentin / Q000002:abnormalities; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008382:Marfan Syndrome / Q000150:complications*; D008875:Middle Aged; D010510:Periodontal Diseases / Q000209:etiology; D010512:Periodontal Index; D012044:Regression Analysis; D012307:Risk Factors; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D014076:Tooth Diseases / Q000209:etiology*; D014092:Tooth Root / Q000002:abnormalities