Sensitivity enhancement of DNA sensors by nanogold surface modification.
A novel amplified microgravimetric gene sensing system was developed using quartz crystal microbalance modified by gold nanoparticles anchored on its 1,6-hexanedithiol modified gold electrode surface, and ultrasensitive detection of DNA hybridization was accomplished at the level of at least 2 x 10(-16) M.
Liu
Tao
T
Laboratory of Colloid and Interface Science, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Science, Beijing 100080, People's Republic of China.
Tang
Ji'an
J
Jiang
Long
L
D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis*; D017979:Gold Colloid / Q000737:chemistry*; D007700:Kinetics; D036103:Nanotechnology / Q000379:methods; D009693:Nucleic Acid Hybridization / Q000379:methods*; D011791:Quartz / Q000737:chemistry; D012680:Sensitivity and Specificity
D017979:Gold Colloid; D011791:Quartz; D004247:DNA