Big G, little G: G proteins and actin cytoskeletal reorganization.
It has been known for some time that stimulation of heterotrimeric G protein-coupled receptors can cause cytoskeletal reorganization. A recent report in Developmental Cell demonstrates that the activation of a tyrosine kinase, C-terminal Src kinase, by heterotrimeric G protein subunits provides the trigger for Rho-dependent actin stress fiber formation.
Luttrell
Louis M
LM
The Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
D000199:Actins / Q000378:metabolism*; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
D000199:Actins; D011956:Receptors, Cell Surface; D019061:src-Family Kinases; D019204:GTP-Binding Proteins; D020741:rho GTP-Binding Proteins