Decipinin A and decipienolides A and B: new bioactive metabolites from the coprophilous fungus Podospora decipiens.
Decipinin A (1), a new compound with antifungal and antibacterial activity, has been isolated from liquid cultures of the coprophilous fungus Podospora decipiens (JS 270). Two new tetracyclic sesquiterpene lactones, decipienolides A (2) and B (3), were also obtained from this isolate as an inseparable mixture of epimers that showed antibacterial activity. The structures of 1-3 were elucidated by analysis of 1D and 2D NMR data, aided by chemical shift comparisons to related compounds.
Che
Yongsheng
Y
Department of Chemistry, University of Iowa, Iowa City, Iowa, 52242, USA.
Gloer
James B
JB
Koster
Brenda
B
Malloch
David
D
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000187:drug effects; D001315:Australia; D001412:Bacillus subtilis / Q000187:drug effects; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001578:Benzopyrans; D012717:Sesquiterpenes; C464984:decipienolide A; C464985:decipienolide B; C464983:decipinin A