Solid-phase C-C and C-O bond forming reactions using 'traceless' pi-arene-chromium linkers.
The scope of solid-phase reactions utilizing a 'traceless' pi-arene-chromium linker has been expanded to include the addition of organo-lithium reagents to a supported ester group, generation and alkylation of an enolate anion, and substitution via the Mitsunobu reaction. Immobilization of ortho-disubstituted polyfunctionalized arene chromium dicarbonyl species onto the solid support and subsequent, selective transformation is also reported.
Rigby
James H
JH
Department of Chemistry, Wayne State University, Detroit, MI 48202-3929, USA. jhr@chem.wayne.edu
Kondratenko
Mikhail A
MA
D000838:Anions; D001555:Benzene Derivatives / Q000737:chemistry*; D002857:Chromium / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004952:Esters; D008094:Lithium / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D020058:Styrene / Q000737:chemistry
D000838:Anions; D001555:Benzene Derivatives; D003432:Cross-Linking Reagents; D004952:Esters; D009942:Organometallic Compounds; D011137:Polystyrenes; D002857:Chromium; D020058:Styrene; D008094:Lithium