Binding efficiency and transport properties of molecularly imprinted polymer thin films.
A model system for the characterization of molecular recognition events in molecularly imprinted polymers (MIPs) is presented. The use of a biologically inspired, three-point hydrogen-bonding motif and a thin film polymeric matrix allows for pre- and post-polymerization binding properties to be characterized by infrared spectroscopy. A method to determine binding constants was developed and utilized before and after cross-linking. These values showed a 10-fold decrease in binding after polymerization, which was attributed to an increase in molecular confinement after polymerization and a change in the local structural environment of the binding cavity. Transport of the guest molecule was shown to be reversible.
Duffy
Daniel J
DJ
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Das
Kanad
K
Hsu
Shaw L
SL
Penelle
Jacques
J
Rotello
Vincent M
VM
Stidham
Howard D
HD
D000179:Acrylates / Q000737:chemistry*; D007700:Kinetics; D018716:Molecular Mimicry; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D011409:Propylene Glycols / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013698:Templates, Genetic; D013816:Thermodynamics; D013941:Thymine / Q000031:analogs & derivatives*
D000179:Acrylates; D011108:Polymers; D011409:Propylene Glycols; D011725:Pyridines; C105815:tripropylene glycol diacrylate; D013941:Thymine