Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.
A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-kappa B-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
Starnes
Trevor
T
Department of Medicine, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA.
Broxmeyer
Hal E
HE
Robertson
Michael J
MJ
Hromas
Robert
R
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology; D002460:Cell Line; D002478:Cells, Cultured; D003001:Cloning, Molecular; D003114:Colony-Forming Units Assay; D017124:Conserved Sequence; D003545:Cysteine / Q000737:chemistry; D016207:Cytokines / Q000096:biosynthesis*; D006131:Growth Inhibitors / Q000302:isolation & purification* / Q000502:physiology*; D006410:Hematopoiesis / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology*; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000276:immunology*; D023461:Myeloid Progenitor Cells / Q000166:cytology / Q000276:immunology
D016207:Cytokines; D006131:Growth Inhibitors; C464462:IL17D protein, human; D020381:Interleukin-17; D003545:Cysteine