Antibacterial activity of calozeyloxanthone isolated from Calophyllum species against vancomycin-resistant Enterococci (VRE) and synergism with antibiotics.
Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synergism between 1 and vancomycin hydrochloride (VCM) against VRE was also observed. These findings suggest that 1 in combination with VCM against VRE may be useful in controlling VRE infections.
Sakagami
Y
Y
Kajimura
K
K
Wijesinghe
W M N M
WM
Dharmaratne
H R W
HR
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D029759:Calophyllum; D004357:Drug Synergism; D016983:Enterococcus / Q000187:drug effects*; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology*; D044004:Xanthones
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C400966:calozeyloxanthone; D014640:Vancomycin