Primary high-grade mucoepidermoid carcinoma of the minor salivary glands with cutaneous metastases at diagnosis.
Mucoepidermoid carcinoma (MEC) represents 15% of all salivary glands malignancies. Metastatic disease at diagnosis is observed in less than 5% of the cases. The lung is the most commonly involved site. This is the first reported case of high-grade MEC of the salivary gland with skin metastases at diagnosis. This feature was associated with a chemoresistant and aggressive behaviour. Differential diagnosis between metastatic MEC and primary skin MEC is essential for therapeutic management and prognosis.
Locati
L D
LD
Department of Medical Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy.
Quattrone
P
P
Pizzi
N
N
Fior
A
A
Cantù
G
G
Licitra
L
L
D000328:Adult; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology* / Q000556:secondary; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012878:Skin Neoplasms / Q000556:secondary*