title: Uterine malignant mixed Müllerian tumor (Metaplasic carcinoma) in the cat: clinicopathologic features and proliferation indices.
abstract: A homologous malignant mixed Müllerian tumor of the uterus occurring in an 8-year-old Persian cat was described with regard to its clinical and pathologic features. A polypoid multinodular mass of the right uterine horn was shown by an ultrasound examination. Grossly, the right uterine horn was enlarged because of a vegetative and infiltrating tumor, grayish-white in color, that penetrated the uterine wall to the level of the perimetrium. Many metastatic nodules were found in abdominal and thoracic cavities. Histologically, the neoplasm had both carcinomatous and sarcomatous components and was diagnosed as an uterine malignant mixed Müllerian tumor. This is the fourth case reported in cats. The histologic features and proliferation rate of this tumor were similar to the corresponding human neoplasms, which occur mainly in postmenopausal women. The possible hormone dependence of the tumor is briefly discussed.
authors.affiliation: Department of Surgery and Theriogenology, School of Veterinary Medicine, University of Messina, Italy.
authors.forename: P A
authors.initials: PA
authors.lastname: Nicòtina
authors.forename: A
authors.initials: A
authors.lastname: Zanghì
authors.forename: G
authors.initials: G
authors.lastname: Catone
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D005065:Euthanasia; D005260:Female; D007150:Immunohistochemistry; D018200:Mixed Tumor, Mullerian / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D009095:Mullerian Ducts / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D014599:Uterus / Q000473:pathology / Q000648:ultrastructure