[Interferon-induced paranoid psychosis. Review of the literature and case report].
Adverse neuropsychiatric effects under interferon treatment have often been reported. However, the pathogenetic mechanisms have not yet been fully explored. Most frequent are affective disorders, but psychotic decompensations can also occur, as reported in the following case. Thus, taking a detailed psychiatric history is required before starting a therapy with interferon, since past and current psychiatric disorders might imply an increased risk for psychiatric adverse effects.
Kornischka
J
J
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Heinrich-Heine-Universität, Rheinische Kliniken Düsseldorf, Bergische Landstrasse 2, 40629 Düsseldorf.
Burtscheidt
W
W
Gaebel
W
W
D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010259:Paranoid Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin