title: [Castleman's disease. Discussion related to case report].
abstract: Castleman's disease, also called angiofollicular hyperplasia was first described as a distinct entity by Castleman et al in 1956. Now there are described two forms, a localised and a multicentric one. All forms of disease share the same histopathological features with a highly characteristic angiofollicular lymphoid hyperplasia which is either hyalinovascular or plasmocytic. The clinical and biological signs are varied and heterogeneous. The disorder is of unknown origin, but interleukin 6 plays a central part in this disease. Despite the benignity of this "prelymphoma state", an aggressive course with poor prognosis occur usually in the multicentric form. We report a case of Castleman's disease, multicentric variant. This case provides the opportunity for discussing many aspects of this atypical lymphoproliferative disorder.
authors.affiliation: Clinica de Hematologie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
authors.forename: C
authors.initials: C
authors.lastname: Dănăilă
authors.forename: M S
authors.initials: MS
authors.lastname: Mihailovici
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index; D013256:Steroids
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D013256:Steroids