title: Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin.
abstract: We assessed 77 twin pregnancies, comprising complete hydatidiform mole (CHM) and healthy co-twin, to ascertain the risks to the mother and baby of continuing the pregnancy, versus termination. 24 women with histologically confirmed CHM and healthy co-twin pregnancies decided to have a termination. 53 women continued with their pregnancies, though two had to have terminations because of severe pre-eclampsia, and 23 spontaneously aborted (<24 weeks' gestation). 28 pregnancies lasted 24 weeks or more, resulting in 20 livebirths. Chemotherapy to eliminate persistent gestational trophoblastic disease (pGTD) was required in three of 19 women (16%; 95% CI 3-39) who terminated their pregnancies in the first trimester, and in 12 of 58 (21%; 95% CI 11-33%) who continued their pregnancies. CHM and healthy co-twin pregnancies have a high risk of spontaneous abortion, but about 40% result in livebirths, without significantly increasing the risk of pGTD.
authors.affiliation: Trophoblastic Disease Unit, Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London W6 8RF, UK.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Sebire
authors.forename: Marianne
authors.initials: M
authors.lastname: Foskett
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Paradinas
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Fisher
authors.forename: Ros J
authors.initials: RJ
authors.lastname: Francis
authors.forename: Delia
authors.initials: D
authors.lastname: Short
authors.forename: Edward S
authors.initials: ES
authors.lastname: Newlands
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Seckl
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications*; D007231:Infant, Newborn; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000503:physiopathology*; D011256:Pregnancy Outcome; D012307:Risk Factors; D014427:Twins; D014594:Uterine Neoplasms / Q000150:complications*