title: Autopsy-proven determinants of death in HIV-infected patients treated for pulmonary tuberculosis in Sao Paulo, Brazil.
abstract: The aim of this work is to describe and compare pulmonary pathology and proven causes of death in HIV-infected and non-HIV patients treated for tuberculosis, to identify the presence and extension of the lesions, and to suggest appropriate interventions based on the results. Of 246 adult patients (aged > 15) autopsied with tuberculosis and tested for HIV infection at Hospital das Clinicas, School of Medicine, São Paulo University, from January 1994 to December 1996, 100 HIV-infected patients were matched with 44 non-HIV-infected patients. Demographic determinants influencing patients' death were as follows: 1. Age and sex were not found to be important for the histological outcome, but do seem to correlate with HIV infection. Older patients with tuberculosis are less likely to be HIV-infected; 2. Previous tuberculosis and its treatment had no influence on the course of secondary or reinfection tuberculosis; 3. The efficiency of the diagnostic criteria used at the time of death was very low (59.2%); 4. Tuberculosis was more frequently investigated in HIV-infected than in non-HIV-infected patients; 5. Only 79 (56%) of the patients received first line agents for treatment; 6. Patients presented with advanced disease; 7. Their mortality is high, and death occurs early. Morphological determinants with influence on patient's death were related to differences in the spectrum of tuberculosis presentation and time of treatment. Noncaseating generalized multibacillary tuberculosis was likely to be the primary cause of death in HIV-infected patients who died during therapy, whereas deaths of patients occurring after the second course of treatment because of recurrence or incomplete treatment were increased for other manifestations of HIV disease (pyogenic pneumonia, Pneumocystis carinii pneumonia, cerebral toxoplasmosis, wasting syndrome). In these patients, dimorphic tuberculosis, an intermediate reactive spectrum form of presentation, was the predominant histological finding. In the opposite spectrum, paucibacillary tuberculosis, a reactive form of tuberculosis presentation, was equally regarded in non-HIV-infected patients as the primary cause of death after four months of therapy. In the same spectrum, non-HIV-infected patients with tuberculosis, who completed all or most of their treatment, died of associated diseases after therapy (alcoholism, cancer, diabetes mellitus). Autopsy-proven determinants of death were associated with HIV status, the spectrum of tuberculosis presentation, and time of treatment. Early treatment for tuberculosis and associated diseases can improve survival and the quality of life even of highly immunosuppressed patients.
authors.affiliation: Division of Infectious Diseases, Hospital das Clinicas, School of Medicine, University of São Paulo, Brazil.
authors.forename: Eliana Battaggia
authors.initials: EB
authors.lastname: Gutierrez
authors.forename: Dirce Maria Trevisan
authors.initials: DM
authors.lastname: Zanetta
authors.forename: Paulo Hilário Nascimento
authors.initials: PH
authors.lastname: Saldiva
authors.forename: Vera Luiza
authors.initials: VL
authors.lastname: Capelozzi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000401:mortality / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D001938:Brazil / Q000453:epidemiology; D002423:Cause of Death; D015658:HIV Infections / Q000150:complications* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D015996:Survival Rate; D014397:Tuberculosis, Pulmonary / Q000209:etiology* / Q000401:mortality / Q000473:pathology