title: Correlation between serum creatinine, creatinine clearance, the calculated creatinine clearance and the glomerular filtration rate in heart transplant patients.
abstract: Assessment of glomerular filtration rate (GFR) in heart transplant (HTx) patients is based on serum creatinine (sCr), the endogenous creatinine clearance (C(Cr)) and radionuclide GFR (rGFR); however, the latter is expensive and time consuming. We reviewed the data of 32 adult HTx patients to determine the correlation between sCr, C(Cr), the calculated C(Cr) (Calc.C(Cr); based on gender, age, weight and sCr) and rGFR in long-term (>1 year) HTx patients receiving calcineurin inhibitors. The Calc.C(Cr) was found to have the best correlation with rGFR (r(2) = 0.65), followed by C(Cr) (r(2) = 0.53) and sCr (r(2) = 0.38). The use of Calc.C(Cr) to estimate GFR may be cost-effective in assessing renal function after HTx.
authors.affiliation: Department of Medicine, Division of Transplantation, Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec, Canada. marcelo.cantarovich@muhc.mcgill.ca
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cantarovich
authors.forename: Nadia
authors.initials: N
authors.lastname: Giannetti
authors.forename: Renzo
authors.initials: R
authors.lastname: Cecere
mesh_terms: D000368:Aged; D003362:Cost-Benefit Analysis; D003401:Creatine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D016027:Heart Transplantation; D006801:Humans; D007677:Kidney Function Tests / Q000191:economics* / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D003401:Creatine