Diverse vacA allelic types of Helicobacter pylori in Korea and clinical correlation.
Helicobacter pylori has a diversity of vacA allelic types. The purpose of this study was to correlate the vacA status and the clinical outcome. After constructing specific primers for the vacA signal sequence, H. pylori-positive antral biopsy specimens were examined for the vacA status in 25 gastric ulcers, 31 duodenal ulcers, 22 gastric cancers, 42 chronic gastritis, and 8 gastroduodenal ulcers. The relationship between the vacA allele and the clinical disease was examined. The vacA genotype s1c/m1 is predominant in Korea (71/128, 55.5%). Other strains including s1b or s2 were not found in this study. s1c/m1 was more prominent in duodenal ulcers, than in gastric ulcers (p=0.041) and cancer (p=0.029). Seven out of 8 patients with gastric and coexistent duodenal ulcers had the s1c/m1 allele. No statistical differences in the positive rates of the s1a/m1, s1a/m2, and s1c/m2 alleles among the disease groups were found. In conclusion, s1c/m1 is the main vacA allele in Korea and it is particularly associated with duodenal ulcers.
Choe
Yon Ho
YH
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim
Pum Soo
PS
Lee
Don Haeng
DH
Kim
Hyung Kil
HK
Kim
Young Soo
YS
Shin
Yong Woon
YW
Hwang
Tae Sook
TS
Kim
Hyeon Joo
HJ
Song
Sun Uk
SU
Choi
Mi Sook
MS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000595:Amino Acid Sequence / Q000235:genetics; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002648:Child; D016481:Helicobacter Infections / Q000503:physiopathology / Q000821:virology; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D007723:Korea; D008875:Middle Aged; D008969:Molecular Sequence Data
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori