TNF alpha and IL-6 involvement in surgical trauma. II. In vitro cytokine production.
The study aimed to correlate TNF alpha and IL-6 dynamics during surgical trauma as well as the changes which appear in the circulating monocytes' response after LPS stimulation in vitro. Three patients with major abdominal operations were chosen and serial blood samples were taken before, during and after the operation. Normal unmatched individuals were used as control group during a two hours bed resting period. Both TNF alpha and IL-6 in vitro production showed similar patterns with an initial drop and almost full recovery 24 hours after the operation. We propose a model for TNF alpha and IL-6 role in trauma induced inflammation.
Dimofte
G
G
School of Medicine, University of Medicine and Pharmacy Gr.T. Popa Iaşi.
Alexander
A
A
Carlson
G
G
Little
R
R
Irving
M
M
D034841:Abdominal Cavity / Q000601:surgery*; D000328:Adult; D006801:Humans; D007249:Inflammation / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha