title: Intrarectal administration of 5-aminosalicylic acid to rabbits and dogs.
abstract: Intrarectal administration of 5-aminosalicylic acid (5-ASA) to rabbits and dogs was performed to obtain safety data. Groups of rabbits and dogs received twice daily intrarectal doses of 250, 500 or 1000 mg 5-ASA for 14 consecutive days. Treatment had no adverse effect on the behaviour or performance of the animals and microscopic examination revealed no evidence of systemic or local toxicity.
authors.affiliation: LAB Pre-Clinical Research International Inc., Laval, Quebec, Canada. berrymanl@preclin.com
authors.forename: E L
authors.initials: EL
authors.lastname: Berryman
authors.forename: A C
authors.initials: AC
authors.lastname: Zerouala
authors.forename: C
authors.initials: C
authors.lastname: Meschter
authors.forename: J
authors.initials: J
authors.lastname: Spenard
mesh_terms: D000285:Administration, Rectal; D000636:Aminosalicylic Acids / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D000818:Animals; D019540:Area Under Curve; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D007668:Kidney / Q000378:metabolism; D008297:Male; D019804:Mesalamine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D011817:Rabbits; D012737:Sex Factors
chemical_list: D000636:Aminosalicylic Acids; D019804:Mesalamine; C028836:N-acetyl-5-aminosalicylic acid