title: Goniolactones A-F, six new styrylpyrone derivatives from the roots of Goniothalamus cheliensis.
abstract: Six new styrylpyrone derivatives, goniolactones A-F (1-6), have been isolated from the roots of Goniothalamus cheliensis. The structures and stereochemistry of the new compounds were elucidated by interpretation of spectroscopic data and chemical methods. The relative configuration of goniolactone A (1) was determined by X-ray crystallography analysis, and the absolute configurations of goniolactones A (1) and B (2) were established by Mosher's method. Goniolactone B (2) exhibited significant cytotoxicity against A2780, HCT-8, and KB cells with IC(50) values of 7.40, 4.43, and 7.23 microM, respectively.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Si
authors.initials: S
authors.lastname: Wang
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D002460:Cell Line / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007413:Intestinal Mucosa / Q000187:drug effects; D007624:KB Cells / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D011753:Pyrones