[Significance of nitric oxide function in development of cardiac hypertrophy under condition of experimental renal hypertension].
The development of cardiac hypertrophy was studied under condition of experimental renal hypertension on the rat. The number of cardiac nitric oxide synthase (NOS)-positive neurones increased simultaneously with the increase in NOS-activity in these neurones. A connection was found between the development of cardiac hypertrophy and the activity of NOS in cardiomiocytes. The involvement of NO in the development cardiac hypertrophy as auto- and paracrine regulator is supposed.
Tishchenko
O V
OV
Department of Histology, Medical State University, Vladiovostok.
Eliseeva
E V
EV
Motavkin
P A
PA
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology*; D002452:Cell Count; D004195:Disease Models, Animal; D005557:Formaldehyde; D006321:Heart / Q000294:innervation; D006977:Hypertension, Renal / Q000139:chemically induced / Q000150:complications* / Q000201:enzymology; D007150:Immunohistochemistry; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D009474:Neurons / Q000201:enzymology; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats
D005557:Formaldehyde; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase