The cardiac component of cardiac cachexia.
BACKGROUND
Recent evidence suggests the importance of noncardiac mechanisms in the genesis of the syndrome of cardiac cachexia. This raises the question of the relative role of the heart itself in this syndrome. This study sought to assess the cardiac dimensions, mass, and function and changes in these parameters over time in patients with chronic heart failure with and without cachexia.


METHODS
Doppler echocardiography was performed in 28 patients with nonedematous weight loss (>7.5% over a period of >6 months) compared with 56 matched patients without weight loss in a ratio of 1:2 (age 71 +/- 13 vs 67 +/- 8 years, P =.07; New York Heart Association class 2.9 +/- 0.7 vs 2.6 +/- 0.6, P =.08). In 18 cachectic and 35 noncachectic patients with previous echocardiographic recordings, we analyzed the changes in left ventricular (LV) dimensions and mass over time.


RESULTS
Cardiac dimensions including LV diastolic (69 +/- 9 mm vs 67 +/- 13 mm) and systolic cavity diameter (58 +/- 11 mm vs 55 +/- 15 mm), LV mass (480 +/- 180 g vs 495 +/- 190 g), and LV systolic and diastolic function including fractional shortening (16% +/- 10% vs 18% +/- 10%), isovolumic relaxation time (29 +/- 22 ms vs 36 +/- 27 ms), and E/A ratio (2.7 +/- 1.6 vs 3.3 +/- 2.9) did not differ between cachectic and noncachectic patients (all P >.1). By analyzing changes in LV mass over time, we found an increase (>20%) in 2 (11%) cachectic and 14 (40%) noncachectic patients and a decrease in LV mass (>20%) in 9 (50%) cachectic and 8 (23%) noncachectic patients (chi2 test, P <.05).


CONCLUSIONS
Although no specific cardiac abnormality could be detected echocardiographically in cachectic patients compared with patients with noncachectic chronic heart failure in a cross-sectional study, over time a significant loss of LV mass (>20%) occurs more frequently in patients with cardiac cachexia.
Florea
Viorel G
VG
Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom. flore022@tc.umn.edu
Henein
Michael Y
MY
Rauchhaus
Mathias
M
Koloczek
Veronika
V
Sharma
Rakesh
R
Doehner
Wolfram
W
Poole-Wilson
Philip A
PA
Coats
Andrew J S
AJ
Anker
Stefan D
SD
D002100:Cachexia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D004452:Echocardiography; D006333:Heart Failure / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology