Ectopic growth hormone-releasing hormone secretion by thymic carcinoid tumour.
The case of a 33-year-old-woman with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome and acromegaly due to ectopic growth hormone-releasing hormone (GHRH) secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, somatostatin and alpha-subunit in the tumour cells. A previously undescribed new germ line mutation of the MEN1 protein gene was revealed.
Boix
E
E
Department of Endocrinology, Universitary Hospital of Alicante, University Miguel Hernández, Spain. ev.boixc@coma.es
Picó
A
A
Pinedo
R
R
Aranda
I
I
Kovacs
K
K
D000172:Acromegaly / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002276:Carcinoid Tumor / Q000737:chemistry / Q000188:drug therapy / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D018095:Germ-Line Mutation; D013007:Growth Hormone-Releasing Hormone / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D018761:Multiple Endocrine Neoplasia Type 1 / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000032:analysis / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000627:therapeutic use; D013004:Somatostatin / Q000031:analogs & derivatives / Q000032:analysis / Q000627:therapeutic use; D013953:Thymus Neoplasms / Q000737:chemistry / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D010456:Peptides, Cyclic; C060347:lanreotide; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone