title: Atrial fibrillation after DDDR pacemaker implantation.
abstract: BACKGROUND
  Newer implantable pulse generators have data storage capabilities that permit detection of multiple episodes of atrial fibrillation (AF). This study evaluated the clinical predictors and time course of AF development in a general pacemaker population.
  
  
  RESULTS
  Patients (n = 231) received DDDR pacemakers with features that permit detection and storage of information about the date, time of onset, and duration of multiple, sequential episodes of AF. Patients were followed for 718+/-383 days. Time to first occurrence of AF, interval between first and second episode of AF, and total AF burden were determined at each follow-up visit. AF occurred more often in patients (68%) with sinus node disease than in patients with AV block (37%; P < 0.001). Time to first occurrence of AF was 21.2 days (95% confidence interval [CI] 14.7 to 30.6 days) after pacemaker implantation. AF burden initially decreased significantly in patients (0.8 hours/day, 95% CI 0.7 to 0.9 at 8 weeks after implant vs 0.6 hours/day, 95% CI 0.4 to 0.8 at 12 months after implant; P = 0.005) but then increased significantly during long-term follow-up (2.0 hours/day, 95% CI 1.0 to 3.7 at 48 months after implant; P = 0.008). The long-term increase in AF burden was seen predominantly in patients with sinus node disease. A prior history of AF and the duration of follow-up were independent predictors of AF occurrence.
  
  
  CONCLUSIONS
  AF develops frequently after dual-chamber pacemaker implantation. AF burden increases progressively over the long term.
authors.affiliation: Cardiovascular Research Group and the Division of Cardiology, The University of Calgary and Foothills Medical Centre, Alberta, Canada. amgillis@ucalgary.ca
authors.forename: Anne M
authors.initials: AM
authors.lastname: Gillis
authors.forename: Margaret
authors.initials: M
authors.lastname: Morck
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006325:Heart Atria / Q000473:pathology / Q000601:surgery; D006327:Heart Block / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006352:Heart Ventricles / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011237:Predictive Value of Tests; D012008:Recurrence; D013995:Time; D013997:Time Factors; D016896:Treatment Outcome