title: Study of the effects of microgravity on cell growth of human antibody producing cells and their secretions.
abstract: Several attempts have been made to investigate the effects of microgravity on the growth and function of animal cells. Cellular activation of immune T lymphocytes is greatly affected by microgravity. On the other hand, little is known about the effects of microgravity on B lymphocytes, another major class of immune lymphocytes, their growth or antibody production. Our approach to investigate the human B lymphocytes was to compare cell growth, nutrient consumption, and antibody secretion by a human B cell hybridoma between the cells cultured in space and the ground culture.
authors.affiliation: Laboratory of Biological Science, Mitsui Pharmaceuticals, Inc.
authors.forename: T
authors.initials: T
authors.lastname: Suganuma
authors.forename: H
authors.initials: H
authors.lastname: O'oka
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
mesh_terms: D000641:Ammonia / Q000378:metabolism; D000917:Antibody Formation / Q000502:physiology*; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D002455:Cell Division; D002460:Cell Line; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D013026:Space Flight; D014893:Weightlessness
chemical_list: D007075:Immunoglobulin M; D005973:Glutamine; D000641:Ammonia