Postnatal survival of rat offspring prenatally exposed to pure 2,4-dichlorophenoxyacetic acid (2,4-D).
In previous report on prenatal developmental effects of pure 2,4-dichlorophenoxyacetic acid (2,4-D) in rat, we found that this chemical was maternally toxic, embryolethal, and that it induced urogenital malformations in the fetuses. In the present report, we investigated the postnatal survival of the offspring prenatally exposed to 2,4-D during organogenesis, to determine the participation of urogenital malformations on postnatal survival. We used doses of 70 mg, 110 mg and 150 mg, which were each found to induce significant urogenital malformations, when administered in different periods of organogenesis: GD 6 to 15, GD 6 to 10, and GD 11 to 15. We found that 2,4-D has a significant influence on progeny viability by increasing the postnatal death. The kidney and urinary tract malformations induced in the fetuses might be the cause of the increased rate of postnatal death. 2,4-D did not impair the postnatal growth of the unaffected offspring.
Fofana
Djibril
D
Department of Pediatrics, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan. fofana@med3.kufm.kagoshima-u.ac.jp.
Kobae
Hidehiko
H
Sameshima
Kiyoko
K
Miyata
Koichiro
K
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006540:Herbicides / Q000633:toxicity*; D007668:Kidney / Q000002:abnormalities; D018811:Maternal Exposure; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014551:Urinary Tract / Q000002:abnormalities
D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid