[Effects of basic fibroblast growth factor on the healing of cutaneous chronic wounds].
OBJECTIVE
To observe the effects of basic fibroblast growth factor(bFGF) on the healing of cutaneous chronic wounds.


METHODS
Twenty-eight cases with thirty-three wounds from trauma, diabetes, pressure and radiation injuries were locally treated with bFGF in a dosage of 150 U/cm2 wounds. The healing time of wounds was used to evaluate the treatment results.


RESULTS
The healing time in all of chronic wounds were accelerated. All wounds from trauma, diabetes and pressure were healed within 4 weeks and another 2 wounds from radiation injuries were healed over 4 weeks. The healing rate within 4 weeks was 93.9%.


CONCLUSIONS
The results indicate that bFGF can be used as a promoter to accelerate the healing of chronic wounds in clinic.
Fu
X B
XB
304th Hospital of PLA, Beijing, P. R. China 100037.
Guo
Z R
ZR
Sheng
Z Y
ZY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002908:Chronic Disease; D017719:Diabetic Foot / Q000628:therapy*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D006801:Humans; D007869:Leg Injuries / Q000150:complications; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D012883:Skin Ulcer / Q000209:etiology / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects*
D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2