[The experimental study of membrane-guided tissue regeneration of bone].
OBJECTIVE
To confirm membrane-guided tissue regeneration in the healing course of segmental bone defects and study the mechanism.


METHODS
Segmental, 1 cm osteoperiosteal defects were produced in both radii of 12 rabbits. One side was covered with hydroxyapatite/polylactic acid(HA/PLA) membrane encapsulated as a tube. The contralateral side served as an untreated control. Healing courses were detected by radiographic and histologic examinations.


RESULTS
All control sides showed nonunion, whereas there were consistent healing pattern in test sides.


CONCLUSIONS
Membrane technique can promote bone regeneration.
Yang
G C
GC
Department of Plastic Surgery, General Hospital of Guang zhou Military Region, Guangzhou, Guangdong, P. R. China 510010.
Situ
P
P
Chen
B
B
D000818:Animals; D001861:Bone Regeneration; D005260:Female; D017102:Fracture Healing; D048091:Guided Tissue Regeneration; D006882:Hydroxyapatites; D019344:Lactic Acid; D008297:Male; D011091:Polyesters; D011108:Polymers; D011817:Rabbits; D011885:Radius Fractures / Q000503:physiopathology* / Q000628:therapy
D006882:Hydroxyapatites; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)