[The response to combined therapy of hepatic encephalopathy in patients with hepatic cirrhosis].
Combined therapy with gepa-merz (L-ornitine-L-aspartate) and lactulose (a synthetic disaccharide) was given to 40 patients with hepatic encephalopathy and toxic hepatic cirrhosis in decompensation. Combination of gepa-merz with lactulose was effective in the above patients. Moreover, it is an optimal one as it has a double impact on ammonia toxicity which is a basic neurotoxin in pathogenesis of hepatic encephalopathy.
Maev
I V
IV
V'iuchnova
E S
ES
Lebedeva
E G
EG
Iakovenko
E I
EI
Dicheva
D T
DT
D000328:Adult; D004151:Dipeptides / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007792:Lactulose / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged
D004151:Dipeptides; D005765:Gastrointestinal Agents; D007792:Lactulose; C002939:ornithylaspartate