Cytogenetic and molecular characterization of eight new reciprocal translocations in the pig species. Estimation of their incidence in French populations.
Eight new cases of reciprocal translocation in the domestic pig are described. All the rearrangements were highlighted using GTG banding techniques. Chromosome painting experiments were also carried out to confirm the proposed hypotheses and to accurately locate the breakpoints. Three translocations, rcp(4;6)(q21;p14), rcp(2;6)(p17;q27) and rcp(5;17)(p12;q13) were found in boars siring small litters (8.3 and 7.4 piglets born alive per litter, on average, for translocations 2/6 and 5/17, respectively). The remaining five, rcp(5;8)(p12;q21), rcp(15;17)(q24;q21), rcp(7;8)(q24;p21), rcp(5;8)(p11;p23) and rcp(3;15)(q27;q13) were identified in young boars controlled before entering reproduction. A decrease in prolificacy of 22% was estimated for the 3/15 translocation after reproduction of the boar carrier. A parental origin by inheritance of the translocation was established for the (5;8)(p11;p23) translocation. The overall incidence of reciprocal translocations in the French pig populations over the 2000/2001 period was estimated (0.34%).
Ducos
Alain
A
UMR INRA-ENVT de cytogénétique des populations animales, Ecole nationale vétérinaire de Toulouse, 23 Chemin des capelles, 31076 Toulouse Cedex 3, France. a.ducos@envt.fr
Pinton
Alain
A
Yerle
Martine
M
Séguéla
Anne
A
Berland
Hélène-Marie
HM
Brun-Baronnat
Corinne
C
Bonnet
Nathalie
N
Darré
Roland
R
D000818:Animals; D002871:Chromosome Banding; D020223:Chromosome Painting; D003582:Cytogenetics; D005260:Female; D005602:France; D005828:Genetics, Population; D007621:Karyotyping; D008297:Male; D013552:Swine / Q000235:genetics*; D014178:Translocation, Genetic