[Cigarette smoking and lung cancer-elucidating an enigma].
The complexity of tobacco smoke leads to some confusion about mechanisms by with is caused lung cancer. Tobacco smoke contains many carcinogens, but 20 of them are deeply involved in causing lung cancer induction. Of these, polycyclic aromatic hydrocarbons and tobacco specific nitrosamine are likely to play a major role. This review include a discussion of the mechanisms of interaction between DNA and tobacco smoke carcinogens and the relationships with mutations in oncogenes and tumor suppressor genes. By focusing in this review on several important carcinogens in tobacco smoke, the complexities in understanding tobacco-induced cancer can be reduced, and new approaches for lung cancer prevention can be envisioned.
Ciornea
L
L
Facultatea de Medicină Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Clinica Radiologie-Oncologie, Spitalul Sf. Spiridon Iaşi.
Miron
L
L
Ghiorghiu
S
S
D006266:Health Education; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000517:prevention & control; D009602:Nitrosamines / Q000009:adverse effects; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects; D012907:Smoking / Q000009:adverse effects*
D009602:Nitrosamines; D011084:Polycyclic Aromatic Hydrocarbons