T cell immunity in lymphoid and non-lymphoid tissues.
Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.
Lefrançois
Leo
L
Division of Immunology, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1319, USA. llefranc@neuron.uchc.edu
Masopust
David
D
D000818:Animals; D002465:Cell Movement; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology*; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*