title: Suberosols A-D, four new sesquiterpenes with beta-caryophyllene skeletons from a Taiwanese gorgonian coral Subergorgia suberosa.
abstract: Four new beta-caryophyllene-derived sesquiterpenes alcohols, suberosols A (1), B (2), C (3), and D (4), along with two known beta-caryophyllene-derived sesqueterpene ketones, buddledins C (5) and D (6), were isolated from a Taiwanese gorgonian coral Subergorgia suberosa. The structures of 1-4 were determined on the basis of extensive spectroscopic analyses. Cytotoxicity of these compounds toward various cancer cell lines is also described.
authors.affiliation: Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Guey-Horng
authors.initials: GH
authors.lastname: Wang
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Li-Tang
authors.initials: LT
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D008175:Lung Neoplasms; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes