[Alterations of rheological properties of blood in systemic sclerodermia].
OBJECTIVE
To study hemorheological status in systemic sclerosis (SS) patients.


METHODS
Macro- and microrheology of blood were investigated in 70 SS patients. The rate of spontaneous aggregation of red blood cells [T1(s)], durability of the largest units [Ia2.5(%)], general hydrodynamic durability of units [beta(s-1)], limit of fluidity [tau 0 (mPa)], Casson viscosity K (mPa/s) were determined.


RESULTS
The total severity of hemorheological disturbances was 1.90 +/- 0.07 with T1 = 4.98 +/- 1.52s, beta = 62.76 +/- 19.32s, Ia 2.5 = -0.78 +/- 12.83%, tau 0 = 7.00 +/- 0.45 mPa. The Casson viscosity did not differ from normal levels. Plasma viscosity was 1.71 +/- 0.18 rel units, viscosity of sera 1.55 +/- 0.14 rel.units. The severity of hemorheological disturbances did not differ in cute and chronic courses but the parameter beta (72.0 +/- 4.5) was significantly higher (p < 0.05) in the acute course. The severity of hemorheological disturbances was highest in SS patients with cardiac disease (p < 0.05) and in 10 year SS duration.


CONCLUSIONS
The course of SS is complicated by progressive hyperaggregation syndrome promoting development of visceral pathology. Active correction of hemorheology is pathogenetically validated in SS.
Alekperov
R T
RT
Vyshlova
M A
MA
Balabanova
R M
RM
Firsov
N N
NN
D000293:Adolescent; D000328:Adult; D000368:Aged; D004903:Erythrocyte Aggregation; D005260:Female; D018056:Hemorheology; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D012720:Severity of Illness Index