title: Insulin resistance syndrome in women with prior history of gestational diabetes mellitus.
abstract: The purpose of this study was to determine the prevalence of insulin resistance syndrome (IRS) and the risk factors for developing IRS among women with a history of gestational diabetes mellitus (GDM), compared with controls over 11 postdelivery years. Assessments of 106 women with a prior history of GDM and 101 controls were done on six occasions from 4-11 yr after delivery. Tests included glucose, insulin, lipids, blood pressure, and body measurements. The risk of IRS was analyzed by Cox regression. The results were that 27.2% of GDM and 8.2% of controls developed IRS by 11 yr after delivery. The hazard of developing IRS was 5.6 times (95% confidence interval = 2.6-12.3) among women with prepregnant obesity (body mass index >27.3 kg/m(2)), compared with women without prepregnant obesity and 4.4 times (95% confidence interval = 1.7-11.1) in women with a history of GDM, compared with controls. At 11 yr after delivery, the cumulative hazard for developing IRS in the next 2 yr was 26 times higher among GDM with prepregnant obesity, compared with controls without prepregnant obesity. We concluded that obesity and GDM in a prior pregnancy are significant risk factors for developing IRS over time. Early detection of markers of IRS is vital for possible prevention of type 2 diabetes and cardiovascular adverse events in women.
authors.affiliation: Department of Community Health, Women and Infants' Hospital, Brown Medical School, 101 Dudley Street, Providence, RI 02912, USA.
authors.forename: Anila
authors.initials: A
authors.lastname: Verma
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Boney
authors.forename: Richard
authors.initials: R
authors.lastname: Tucker
authors.forename: Betty R
authors.initials: BR
authors.lastname: Vohr
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000150:complications*; D005260:Female; D006801:Humans; D008499:Medical Records; D024821:Metabolic Syndrome / Q000502:physiology*; D009765:Obesity / Q000150:complications; D011247:Pregnancy; D015995:Prevalence; D016016:Proportional Hazards Models; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors