title: Neonatal exposure to endocrine disruptors suppresses juvenile testis weight and steroidogenesis but spermatogenesis is considerably restored during puberty.
abstract: Neonatal exposure to endocrine disruptors induces developmental abnormalities in the male reproductive system. As to investigate whether neonatal exposure affects spermatogenesis in juvenile and pubertal testes, Sprague-Dawley rat pups were given various endocrine disruptors by a single injection on the day of birth at concentrations ranging between 4 microM and 40 mM and sacrificed on day 21 (juvenile) or 50 (puberty). The testes were weighed and examined histologically at each stage. Further, the metabolites of steroidogenesis were analyzed using normal-phase high performance liquid chromatography. Neonatal exposure significantly reduced testis weights and steroid biosynthesis of juveniles, but they were highly restored at puberty.
authors.affiliation: Department of Biochemistry, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-0829, Japan. kuwada@med.kitasato-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kuwada
authors.forename: Rei
authors.initials: R
authors.lastname: Kawashima
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hisako
authors.initials: H
authors.lastname: Kojima
authors.forename: Hideyo
authors.initials: H
authors.lastname: Hasumi
authors.forename: Jun
authors.initials: J
authors.lastname: Maki
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugano
mesh_terms: D000728:Androgens / Q000096:biosynthesis*; D000818:Animals; D000831:Animals, Newborn; D007700:Kinetics; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012741:Sexual Maturation; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development* / Q000502:physiology
chemical_list: D000728:Androgens