[Chromatographic analysis of low molecular weight fraction of cerebrospinal fluid in children with acute neuroinfections].
Low molecular-weight (oligopeptide) fraction of the cerebrospinal fluid was analyzed by high-performance reversed phase liquid chromatography in 30 children with bacterial and viral neuroinfections. The incidence and height of chromathoraphic peaks in bacterial meningitis depended on the disease etiology, stage, and severity. Qualitative and quantitative composition of low molecular-weight fraction of the liquor varied in patients with viral neuroinfections, depending on the severity of the cerebral parenchyma involvement. Differences in chromatographic profiles in complicated and uneventful course of neuroinfections indicate a possible damaging, protective, or regulatory effect of the liquor peptides. These data focus the attention on the role of oligopeptides in the genesis of neuroinfectious process, significance of search for peptide markers, their further isolation, identification, and development of test systems available for clinical application.
Alekseeva
L A
LA
Shatik
S V
SV
Sorokina
M N
MN
Karasev
V V
VV
D002648:Child; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid*; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid*; D008970:Molecular Weight; D009479:Neuropeptides / Q000134:cerebrospinal fluid* / Q000737:chemistry
D009479:Neuropeptides