Hereditary thrombophilias are not associated with a decreased live birth rate in women with recurrent miscarriage.
OBJECTIVE
To assesses the live birth rate without treatment in women with hereditary thrombophilia who have recurrent miscarriage and women without thrombophilia who have recurrent miscarriage.


METHODS
Prospective observational study.


METHODS
Tertiary referral unit in university hospital.


METHODS
One hundred twenty women with thrombophilia and 65 women without thrombophilia.


METHODS
Number of live births or repeated miscarriages.


RESULTS
Of the 185 patients, 44 with thrombophilia and 26 without thrombophilia have conceived. Nineteen of the 44 pregnancies (43.2%) in thrombophilia patients have terminated in live births, compared with 8 of 26 pregnancies (30.8%) in patients without thrombophilia. This difference is not statistically significant.


CONCLUSIONS
Hereditary thrombophilia did not seem to affect the live birth rate in women with recurrent miscarriage.
Carp
Howard
H
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel. carp@netvision.net.il
Dolitzky
Mordechai
M
Tur-Kaspa
Ilan
I
Inbal
Aida
A
D000026:Abortion, Habitual / Q000150:complications* / Q000503:physiopathology*; D000328:Adult; D001723:Birth Rate; D005260:Female; D006720:Homozygote; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology; D011446:Prospective Studies; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics*
D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)