Malaria, monocytes, macrophages and myeloid dendritic cells: sticking of infected erythrocytes switches off host cells.
The adhesive phenotypes expressed by Plasmodium-falciparum-infected erythrocytes were previously thought simply to permit sequestration of parasites in the peripheral circulation. Recent work has illuminated how falciparum-infected erythrocytes may modulate the function of monocytes, macrophages and myeloid dendritic cells through the action of haemozoin from digested haemoglobin and through adhesion of infected cells to their surface.
Urban
Britta C
BC
Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK. burban@hammer.imm.ox.ac.uk
Roberts
David J
DJ
D000818:Animals; D002448:Cell Adhesion; D003713:Dendritic Cells / Q000276:immunology* / Q000648:ultrastructure; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000469:parasitology / Q000648:ultrastructure; D006790:Host-Parasite Interactions; D006801:Humans; D007108:Immune Tolerance; D008264:Macrophages / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D008954:Models, Biological; D009000:Monocytes / Q000276:immunology* / Q000648:ultrastructure; D010963:Plasmodium falciparum / Q000254:growth & development / Q000472:pathogenicity*