title: Lack of association between intussusception and oral polio vaccine in Cuban children.
abstract: Two exploratory investigations found an increased risk of intussusception after oral polio vaccine (OPV). A large, national, population-based study was undertaken in Cuba to investigate a possible association. Three hundred and thirty-five cases of intussusception in children under 2 years of age occurring in 1995-2000 were identified and their OPV records retrieved. The relative incidence (RI) of intussusception in defined periods up to 42 days after OPV in children under 1 year was estimated using the self-controlled case series method, controlling for age and season. The RI was not significantly raised in any of the time intervals examined within the 0-42 day period after OPV. For the period 0-42 days as a whole the RI was 1.11, 95% CI 0.74-1.67. This study does not support the hypothesis that OPV causes intussusception.
authors.affiliation: Direccion Nacional de Epidemiologia, MINSAP, Ciudad de la Habana, Cuba.
authors.forename: M A
authors.initials: MA
authors.lastname: Sardiñas
authors.forename: A Z
authors.initials: AZ
authors.lastname: Cárdenas
authors.forename: G C
authors.initials: GC
authors.lastname: Marie
authors.forename: M S
authors.initials: MS
authors.lastname: Peña
authors.forename: M A
authors.initials: MA
authors.lastname: Santiago
authors.forename: M V
authors.initials: MV
authors.lastname: Sanchez
authors.forename: C P
authors.initials: CP
authors.lastname: Farrington
mesh_terms: D003462:Cuba / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D011051:Poliomyelitis / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D011055:Poliovirus Vaccine, Oral