Elastodynamics and arterial wall stress.
Recent advances in molecular and cell biology have emphasized the fundamental importance of mechanical factors in regulating the structure and function of cells and extracellular matrix in the vasculature. Consequently, there is an ever-greater motivation to calculate accurately the stress and strain fields in the arterial wall and how they change with disease, injury, and clinical treatment. Although there is an extensive literature on arterial mechanics, our understanding is still far from complete. In this paper, we review some of the salient findings with regard to wall properties, suggest some possible improvements in the calculation of wall stress, and identify some unresolved problems for further research.
Humphrey
J D
JD
Department of Biomedical Engineering, Texas A&M University, College Station 77843-3120, USA. jhumphrey@tamu.edu
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D001158:Arteries / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000503:physiopathology*; D004548:Elasticity; D004730:Endothelium, Vascular / Q000503:physiopathology*; D018056:Hemorheology; D006801:Humans; D008955:Models, Cardiovascular; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D013314:Stress, Mechanical; D017539:Tunica Intima / Q000503:physiopathology*