A case of flare syndrome.
The authors describe a case of severe CMV retinitis in a young adult AIDS patient who recovered following first a course of ganciclovir and then HAART. Six months after the initial episode while still under successful HAART, the patient developed an acute episode of retinitis despite a persistent significant improvement in the immunological picture and a very low level of CMV reactivation. The acute episode can be related to an enhanced individual reactivity to minor CMV replication.
Maiello
A
A
Clinica di Malattie Infettive, Universit degli Studi di Torino, Italy.
Racca
D
D
Zeme
D A
DA
Quario
M
M
Sinicco
A
A
Di Perri
G
G
D017088:AIDS-Related Opportunistic Infections / Q000209:etiology*; D000208:Acute Disease; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D000077404:Cidofovir; D017726:Cytomegalovirus Retinitis / Q000209:etiology*; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015774:Ganciclovir / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D019469:Indinavir / Q000008:administration & dosage; D019259:Lamivudine / Q000008:administration & dosage; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D015215:Zidovudine / Q000008:administration & dosage
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D019259:Lamivudine; D015215:Zidovudine; D019469:Indinavir; D003596:Cytosine; D000077404:Cidofovir; D015774:Ganciclovir