Short syntheses of (+/-)-delta-araneosene and humulene utilizing a combination of four-component assembly and palladium-mediated cyclization.
[reaction: see text] The four components shown are assembled in two steps, and the product is converted to araneosene by a short sequence.
Hu
Tao
T
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ
D002384:Catalysis; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis*; D000081222:Monocyclic Sesquiterpenes; D010165:Palladium; D012717:Sesquiterpenes / Q000138:chemical synthesis*
D004224:Diterpenes; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C464439:delta-araneosene; C042686:humulene; D010165:Palladium