title: Determination of zinc (II) in pharmaceuticals based on a flow-through bulk optode.
abstract: A method based on flow injection (FI), was applied for the determination of Zn (II) using a flow-through bulk optode membrane that incorporates 1-(2-pyridylazo)-2-naphthol in a plasticized poly (vinyl chloride) membrane entrapped in a cellulose support. The calibration graph plotting the reflectance at 562 nm versus [Zn (II)] was linear in the range 0.16-3.27 mgl(-1) (2.5 x 10(-6)-5 x 10(-5) M) with a detection limit of 0.10 mgl(-1). The variation coefficients of the sensor response for 0.33 mgl(-1) of Zn (II) were +/-0.11% for consecutive measurements (n=10), +/-0.19% between days (n=5) and +/-0.22% between different membranes (n=6). The sensor can be readily regenerated with the same acetic/acetate carrier of pH 3.9. The FI method proposed was applied to the determination of zinc (II) in pharmaceuticals.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071, Murcia, Spain. spedreno@um.es
authors.forename: M I
authors.initials: MI
authors.lastname: Albero
authors.forename: J A
authors.initials: JA
authors.lastname: Ortuño
authors.forename: M S
authors.initials: MS
authors.lastname: García
authors.forename: C
authors.initials: C
authors.lastname: Sánchez-Pedreño
authors.forename: R
authors.initials: R
authors.lastname: Expósito
mesh_terms: D017022:Flow Injection Analysis; D055095:Optics and Photonics / Q000295:instrumentation*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015032:Zinc / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D015032:Zinc