AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?
This article will discuss the role of two classes of serine/threonine protein kinases in the regulation of gene transcription in mammals. The first is AMP-activated protein kinase (AMPK), which is responsive to changes in the intracellular energy status. The second is the 'stress-activated" family of protein kinases, members of the mitogen-activated protein (MAP) kinase superfamily, whose regulation by a number of extracellular agents (including osmotic stresses, cytokines, and heat) is less well understood. Interest in these enzymes has grown in the past few years due to mounting evidence (both pharmacological and genetic) which has implicated them in the regulation of a number genes important in mammalian metabolism.
Leclerc
Isabelle
I
Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom.
da Silva Xavier
Gabriela
G
Rutter
Guy A
GA
D055372:AMP-Activated Protein Kinases; D000818:Animals; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin; D007515:Islets of Langerhans / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D011384:Proinsulin / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
D007328:Insulin; D009097:Multienzyme Complexes; D011498:Protein Precursors; C013737:preproinsulin; D011384:Proinsulin; D017346:Protein Serine-Threonine Kinases; D020928:Mitogen-Activated Protein Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose