High-dose chemotherapy with autologous stem cell transplantation is an effective treatment of primary refractory Hodgkin's disease. Retrospective study of the Polish Lymphoma Research Group.
We analysed the treatment outcome of primary refractory HD patients managed with high-dose chemotherapy and haematopoietic cell transplantation. Data of 65 adult patients who underwent HDC/ASCT in nine Polish centres for primary resistant Hodgkin's disease between June 1991 and July 2000 were collected retrospectively. Response rate to HDC/ASC: CR, 54%; PR, 20%; less than PR, 15%; early deaths, 11%. Actuarial 3-year OS and PFS were 55% and 36%, respectively. In multivariate analysis, lack of bulky lymph nodes and use of immunotherapy were favourable factors for both OS and PFS. IPF <3 at the time of transplantation was predictive for PFS. However, the prognostic impact of immunotherapy should be interpreted with caution since this group included more patients who achieved CR after HDC/ASCT. The results of HDC/ASCT are encouraging and confirm earlier findings. The role of immunotherapy should be further investigated in prospective trials.
Czyz
J
J
Department of Haematology, Medical University, Gdańsk, ul. Debinki, Poland.
Hellmann
A
A
Dziadziuszko
R
R
Hansz
J
J
Goździk
J
J
Hołowiecki
J
J
Stella-Hołowiecka
B
B
Kachel
Ł
Ł
Knopińska-Posłuszny
W
W
Nagler
A
A
Meder
J
J
Walewski
J
J
Lampka
E
E
Sułek
K
K
Sawicki
W
W
Lange
A
A
Forgacz
K
K
Suchnicki
K
K
Pacuszko
T
T
Skotnicki
A
A
Mensah
P
P
Jurczak
W
W
Kuliczkowski
K
K
Wróbel
T
T
Mazur
G
G
Dmoszyńska
A
A
Wach
M
M
Robak
T
T
Warzocha
K
K
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006689:Hodgkin Disease / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016879:Salvage Therapy; D016019:Survival Analysis; D015996:Survival Rate; D014182:Transplantation, Autologous / Q000401:mortality; D016896:Treatment Outcome