title: Efficient synthesis of 2-bromo-1-[18F]fluoroethane and its application in the automated preparation of 18F-fluoroethylated compounds.
abstract: An efficient synthesis of 2-bromo-1-[18F]fluoroethane from commercially available 1,2-dibromoethane and its integration into an automated preparation device was developed for the routine synthesis of 18F-fluoroethylated compounds. The 1,2-dibromoethane was reacted with the [18F]fluoride/Kryptofix 2.2.2./carbonate complex in acetonitrile at 70 degrees C for 3 min resulting in 60-70% radiochemical yields. The crude reaction mixture was diluted with water, loaded on a LiChrolute EN-cartridge, eluted with acetonitrile and passed through an AluminaB-cartridge. This method provides 2-bromo-1-[18F]fluoroethane with 98% radiochemical purity and <0.1 micromol of 1,2-dibromoethane within 10 min, thus avoiding a purifying distillation step. This method was easily integrated into an automated system for the routine synthesis of 18F-fluoroethylated compounds.
authors.affiliation: Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Comagic
authors.forename: M
authors.initials: M
authors.lastname: Piel
authors.forename: R
authors.initials: R
authors.lastname: Schirrmacher
authors.forename: S
authors.initials: S
authors.lastname: Höhnemann
authors.forename: F
authors.initials: F
authors.lastname: Rösch