title: Stereocontrolled synthesis of linear 22R-homoallylic sterols via a triflic acid-catalyzed 2-oxonia Cope rearrangement.
abstract: [reaction: see text] Poor stereoselectivity caused by the involvement of side reaction pathways was observed in the In(OTf)(3)-catalyzed allyl-transfer reaction (R = electron-withdrawing group). Subsequently, it was found that the employment of triflic acid (TFA) as catalyst could successfully suppress the side reaction pathways and, hence, achieve high stereoselectivity.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. chmlohtp@nus.edu.sg
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
authors.forename: Qi-Ying
authors.initials: QY
authors.lastname: Hu
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Ma