Recent advances in the chemical synthesis of mucin-like glycoproteins.
This purpose of this mini review is to familiarizereaders with the tools currently available for the synthesis of mucin-typeglycoproteins. The article will highlight recent approaches to thesynthesis of glycopeptide fragments bearing complex O-linkedglycans, as well as new strategies for the generation of full-lengthglycoproteins.
Marcaurelle
Lisa A
LA
Center for New Directions in Organic Synthesis, Departmentsof Chemistry and Molecular and Cell Biology, and Howard Hughes MedicalInstitute, University of California, Berkeley, CA 94720, USA.
Bertozzi
Carolyn R
CR
D000595:Amino Acid Sequence; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006023:Glycoproteins / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D009077:Mucins / Q000138:chemical synthesis* / Q000737:chemistry
D006023:Glycoproteins; D009077:Mucins