title: Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration.
abstract: OBJECTIVE
  Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative disorders that may be accompanied by dementia and parkinsonism as clinical symptoms. The purpose of this study was to elucidate cerebral metabolic differences of these two diseases with cognitive impairments by [18F] fluorodeoxyglucose (FDG) and positron emission tomography (PET).
  
  
  METHODS
  A total of 12 patients with PSP (age: 62.8+/-6.0 years old, m: 7, f: 5, Mini-Mental State Examination (MMSE): 23.4+/-2.6), 12 patients with CBD (age: 64.8+/-6.3 years old, m: 6, f: 6, MMSE: 22.9+/-4.5), and age-matched healthy subjects (normal control (NC)) (age: 63.8+/-7.7 years old, m: 7, f: 5) were subjected to FDG-PET to obtain glucose metabolic images. We compared regional cerebral metabolic images by a voxel-by-voxel analysis with statistical parametric mapping (SPM) among PSP, CBD, and NC subjects, and evaluated differences of hypometabolic regions.
  
  
  RESULTS
  The patients with PSP showed reduced cerebral glucose metabolism in the medial and lateral frontal gyri, basal ganglia, and midbrain compared with NC, whereas the patients with CBD showed significant reduction in the parietal lobes (p<0.001). SPM also revealed parietal hypometabolism in CBD patients compared with PSP patients (p<0.001).
  
  
  CONCLUSIONS
  The predominant parietal glucose metabolic reduction in CBD patients was different from previously reported findings. This finding would be the characteristic substance of patients with CBD accompanying cognitive impairments. Our findings suggest that measurement of glucose metabolism by PET and a voxel-based analysis is useful to understand the pathophysiology of these two diseases with cognitive impairments.
authors.affiliation: Division of Imaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-Ko, Himeji, Hyogo 670-0981, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Hosaka
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishii
authors.forename: Setsu
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sasaki
authors.forename: Nobutsugu
authors.initials: N
authors.lastname: Hirono
authors.forename: Etsuro
authors.initials: E
authors.lastname: Mori
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000378:metabolism; D003704:Dementia / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging / Q000378:metabolism; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D020734:Parkinsonian Disorders / Q000209:etiology; D011237:Predictive Value of Tests; D012016:Reference Values; D013003:Somatosensory Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose