title: Apraxia of eyelid closure in Huntington's disease.
abstract: We report a patient with genetically confirmed Huntington's disease (HD) presenting apraxia of eyelid closure (AEC). She was unable to close her eyes at command but was able to blink. Chorea and AEC ameliorated significantly during treatment with olanzapine and riluzole, an inhibitor of glutamate release. AEC is reported in progressive supranuclear palsy, Creutzfeldt-Jakob's disease, amyotrophic lateral sclerosis, and as post-stroke AEC. No report on HD is available so far, although oculomotor disturbances are quite common in this disease.
authors.affiliation: Department of Neurology and Psychiatry, Hospital BHB Eggenberg, Graz, Austria. rm.bonelli@nextra.at
authors.forename: R M
authors.initials: RM
authors.lastname: Bonelli
authors.forename: G
authors.initials: G
authors.lastname: Niederwieser
mesh_terms: D001072:Apraxias / Q000209:etiology*; D001569:Benzodiazepines; D004359:Drug Therapy, Combination; D005141:Eyelid Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D019782:Riluzole / Q000008:administration & dosage / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D001569:Benzodiazepines; D018696:Neuroprotective Agents; D000077152:Olanzapine; D010890:Pirenzepine; D019782:Riluzole; D017367:Selective Serotonin Reuptake Inhibitors