title: Proconvulsive effect of the GABA(B) receptor antagonist, SCH 50911, in rats undergoing ethanol withdrawal syndrome.
abstract: The present study investigated the effect of the GABA(B) receptor antagonist, SCH 50911 [(2S)(+)-5,5-dimethyl-2-morpholineacetic acid], on the occurrence of seizures in ethanol-dependent rats undergoing ethanol withdrawal syndrome. The acute administration of nonconvulsive doses of SCH 50911 (0, 100, 170 and 300 mg/kg, i.p.) resulted in a dramatic facilitation of spontaneous seizure occurrence. This finding, together with the reported ability of the GABA(B) receptor agonist, baclofen, to suppress seizures associated to ethanol withdrawal syndrome, suggests that the GABA(B) receptor may be part of the neural substrate underlying the hyperexcitability of ethanol withdrawal syndrome.
authors.affiliation: Neuroscienze S.c.a r.l., Via Palabanda 9, I-09123 Cagliari (CA), Italy.
authors.forename: Mauro A M
authors.initials: MA
authors.lastname: Carai
authors.forename: Giuliana
authors.initials: G
authors.lastname: Brunetti
authors.forename: Carla
authors.initials: C
authors.lastname: Lobina
authors.forename: Salvatore
authors.initials: S
authors.lastname: Serra
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vacca
authors.forename: Giovanna
authors.initials: G
authors.lastname: Minardi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Colombo
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Gessa
mesh_terms: D020270:Alcohol Withdrawal Seizures / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D003292:Convulsants / Q000009:adverse effects*; D000431:Ethanol / Q000009:adverse effects*; D018756:GABA Antagonists / Q000009:adverse effects*; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D008297:Male; D009025:Morpholines / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D018080:Receptors, GABA-B / Q000502:physiology
chemical_list: C095804:(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid; D003292:Convulsants; D018756:GABA Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D009025:Morpholines; D018080:Receptors, GABA-B; D000431:Ethanol