title: The first successful base-promoted isomerization of propargyl amides to chiral ynamides. Applications in ring-closing metathesis of ene-ynamides and tandem RCM of diene-ynamides.
abstract: [reaction: see text] A highly useful sequence of reactions is described here. These reactions consist of the first successful base-induced isomerizations of propargyl amides to chiral ynamides, applications of these novel ynamides in ring-closure metathesis leading to chiral 2-amidodienes useful for Diels-Alder cycloadditions, and the first successful tandem RCM of diene-ynamides.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Xiong
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: C
authors.initials: C
authors.lastname: Rameshkumar
authors.forename: Jason A
authors.initials: JA
authors.lastname: Mulder
authors.forename: Tyler P
authors.initials: TP
authors.lastname: Grebe