A rare case of ulcerative colitis complicating Wilson's disease: possible association between the two diseases.
A case of ulcerative colitis complicated by Wilson's disease is described. In this case, ulcerative colitis occurred 12 years after the diagnosis of Wilson's disease, and the colitis was intractable to prednisolone and salazosulfapyridine. Because copper is one of the trace elements necessary for antioxidant defenses during inflammatory process, altered copper metabolism may have contributed to the intractability of the ulcerative colitis in this case.
Torisu
Takahiro
T
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. mesaki@intmed2.med.kyushu-u.ac.jp
Esaki
Motohiro
M
Matsumoto
Takayuki
T
Nakamura
Shotaro
S
Azuma
Koichi
K
Okada
Mitsuo
M
Tsuji
Hiroshi
H
Yao
Takashi
T
Iida
Mitsuo
M
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D003300:Copper / Q000378:metabolism; D006527:Hepatolenticular Degeneration / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use; D017211:Treatment Failure
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine; D003300:Copper; D011239:Prednisolone