title: Severe upper gastrointestinal hemorrhage in the newborn.
abstract: Three infants with severe upper gastrointestinal hemorrhage with esophagogastroduodenoscopic (EGD) findings were reported. The underlying conditions of these infants included Down's syndrome, hypoplastic left heart, and diaphragmatic hernia. The precipitating factors were identified in all cases, including prenatal stress, hypoxemia, prolonged ventilatory support, and gastroesophageal reflux. The EGD findings were composed of multiple gastric ulcers and a duodenal ulcer in the first 2 cases, whereas esophagitis and gastritis were noted in the last case. These ulcers were classified as secondary peptic ulcers. All cases responded well to medical treatment, including ranitidine, sucralfate, omeprazole, cisapride, and octreotide.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Thailand.
authors.forename: Lumduan
authors.initials: L
authors.lastname: Wongsawasdi
authors.forename: Nuthapong
authors.initials: N
authors.lastname: Ukarapol
authors.forename: Somporn
authors.initials: S
authors.lastname: Chotinaruemol
mesh_terms: D000208:Acute Disease; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010437:Peptic Ulcer / Q000150:complications* / Q000175:diagnosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents