title: Radiation-induced angiosarcoma of the breast: case report and self-criticism of therapeutic approach.
abstract: Angiosarcoma (AS) of the breast is a rare and highly aggressive vascular cancer. It presents as a primitive or radioinduced form. The case of a 46-year-old woman who underwent quadrantectomy of the breast plus axillary lymph node dissection and radiotherapy postoperatively (QUART) for ductal infiltrant carcinoma is reported in the following. Ten years later, the patient underwent mastectomy with immediate reconstruction, for local recurrence that was diagnosed as an AS of the breast at final pathological examination. She did not receive any adjuvant treatment due to local post-operative complications related to breast reconstruction. We criticize our therapeutic approach and we recommend more attention about local recurrence suggesting that tru-cut needle biopsy of local recurrence of the breast after QUART, should be the correct diagnostic approach.
authors.affiliation: Departement of Surgery, Radiology and Anestesiology, Sezione di Clinica Chirurgica, University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Anania
authors.forename: P C
authors.initials: PC
authors.lastname: Parodi
authors.forename: A
authors.initials: A
authors.lastname: Sanna
authors.forename: E
authors.initials: E
authors.lastname: Rampino
authors.forename: E
authors.initials: E
authors.lastname: Marcotti
authors.forename: C
authors.initials: C
authors.lastname: Di Loreto
authors.forename: C
authors.initials: C
authors.lastname: Zuiani
authors.forename: A
authors.initials: A
authors.lastname: Donini
mesh_terms: D001706:Biopsy; D001943:Breast Neoplasms / Q000209:etiology / Q000532:radiotherapy* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000601:surgery; D019651:Plastic Surgery Procedures