The Duffy antigen/receptor for chemokines (DARC) and prostate cancer. A role as clear as black and white?
Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death among men in the United States. African American men have a 60% greater incidence of prostate cancer and a twofold higher mortality rate than Caucasian men. The Duffy antigen/receptor for chemokines (DARC) is a receptor expressed on erythrocytes and vascular endothelial cells that binds to and clears angiogenic chemokines. The DARC also functions as the erythrocyte receptor for invasion by malarial parasites. Approximately 70% of African Americans lack erythrocyte expression of the DARC as a genetic mechanism of protection against malaria infection. Given the importance of angiogenic chemokines in the development of tumor vascular networks and the chemokine binding properties of the DARC, the possibility that a lack of DARC expression on erythrocytes may represent an epigenetic factor that predisposes African American men to a greater incidence and mortality of prostate cancer should be considered.
Lentsch
Alex B
AB
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0558, USA. alex.lentsch@uc.edu
D000953:Antigens, Protozoan; D044383:Black People / Q000235:genetics; D002352:Carrier Proteins / Q000378:metabolism*; D019743:Chemokines, CXC / Q000145:classification / Q000378:metabolism; D004375:Duffy Blood-Group System; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000208:ethnology* / Q000235:genetics / Q000378:metabolism; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000378:metabolism; D009626:Terminology as Topic; D044465:White People; D001741:Black or African American
C473745:ACKR1 protein, human; D000953:Antigens, Protozoan; D002352:Carrier Proteins; D019743:Chemokines, CXC; D004375:Duffy Blood-Group System; C066001:Duffy antigen binding protein, Plasmodium; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine