Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering.
This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers insulin formulation, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. The cartilage defect was notably repaired using chondrocyte suspension in the thermogelling PLGA-g-PEG compared with a control. This report shows that thermogelling biodegradable PLGA/PEG graft copolymer system can be a promising platform for protein and cell-based therapy.
Jeong
Byeongmoon
B
Pacific Northwest National Laboratory, 902 Battelle Boulevard, P.O. Box 999, K2-44, Richland, Washington 99352, USA. bjeong@ewha.ac.kr
Lee
Kyeonghee M
KM
Gutowska
Anna
A
An
Yuehuei H
YH
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects; D002358:Cartilage, Articular; D019902:Chondrocytes / Q000166:cytology; D003692:Delayed-Action Preparations / Q000737:chemistry*; D003920:Diabetes Mellitus / Q000188:drug therapy; D020100:Hydrogels / Q000737:chemistry* / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D011092:Polyethylene Glycols; D011098:Polyglactin 910; D011108:Polymers; D011506:Proteins / Q000008:administration & dosage; D011817:Rabbits; D051381:Rats; D012996:Solutions; D023822:Tissue Engineering / Q000379:methods
D001672:Biocompatible Materials; D001786:Blood Glucose; D003692:Delayed-Action Preparations; D020100:Hydrogels; D007328:Insulin; D011108:Polymers; D011506:Proteins; D012996:Solutions; C102418:poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; D011098:Polyglactin 910; D011092:Polyethylene Glycols