[Experimental study on stimulation of guided bone regeneration by acid fibroblast growth factor].
OBJECTIVE
To investigate the effect of acid fibroblast growth factor (aFGF) on guided bone regeneration (GBR), to study whether aFGF can promote the repairing ability of GBR in bone defect.


METHODS
10 mm long segmental defects were created in the diaphyses of both radii in 16 New Zealand rabbits. The defect was bridged with a silicon tube. Human recombinant aFGF was instilled into the tube on the experimental side, while the contralateral tube was instilled with saline as control group. The radiographic, gross and histologic examination of the samples were analyzed at 2, 4, 6 and 8 weeks after operation.


RESULTS
On the experimental side, there was new bone formation in the bone medullary cavity, the endosteum and the section surface of the cortex at 2 weeks. At 4 weeks, at the center of the blood clot in the tube there was new bone formation and bone defect was completely healed at 8 weeks. On the control side, new bone formation was less in every period compared with that of the experimental side. At 8 weeks, there was only partial healing of the bone defect.


CONCLUSIONS
It can be concluded that aFGF can promote new bone formation and facilitate GBR in bone defect.
Chen
J N
JN
Department of Orthopedic Surgery, First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, P. R. China 610041.
Tu
C Q
CQ
Gong
Q
Q
D000818:Animals; D001861:Bone Regeneration; D005260:Female; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology*; D017102:Fracture Healing / Q000187:drug effects*; D048091:Guided Tissue Regeneration; D008297:Male; D011817:Rabbits; D011885:Radius Fractures / Q000503:physiopathology; D011994:Recombinant Proteins / Q000494:pharmacology
D011994:Recombinant Proteins; D016220:Fibroblast Growth Factor 1