[Optimization of dosing of finlepsin and finlepsin-retard in patients with partial epilepsy on the basis of population modeling and drug monitoring].
Taking into account the drug monitoring data, twenty-six patients with partial epilepsy were treated with finlepsin (carbamazepin) and finlepsin-retard. According to the therapy, the patients were grouped as following: 11 patients were taking finlepsin, 10--finlepsin-retard and 5 were first treated with finlepsin and then, because of the lack of the effect, assigned to finlepsin-retard. The seizures severity was assessed using special seizures severity scale. Better clinical results (remission and reduction of seizures severity) were found in patients treated with finlepsin-retard as compared to those from other groups. Due to monitoring, a remission was reached using the lower finlepsin dosage. The authors confirm individuality of pharmacokinetic parameters, a need in precise individual treatment strategy and a necessity for controlling drug levels in plasma after replacing one form for another.
Karlov
V A
VA
Bondareva
I B
IB
Andreeva
O V
OV
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D004828:Epilepsies, Partial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance
D000927:Anticonvulsants; D003692:Delayed-Action Preparations; D002220:Carbamazepine