The FAS-670 polymorphism influences susceptibility to multiple sclerosis.
Several studies have reported a defective Fas function in patients with multiple sclerosis (MS). We were interested whether this could result from a genetically altered Fas regulation. We examined the FAS-670 polymorphism in 382 patients with MS and 206 controls, and found that the carriership of allele FAS-670*G was significantly less frequent in patients than in controls. We found no association between the carriership of FAS-670*G and clinical features. For a subgroup of patients, longitudinal MRI data were available. We observed similar brain and lesion volumes in carriers and noncarriers of FAS-670*G. These data suggest that FAS-670*G decreases the risk of developing MS, but does not affect the course of disease.
van Veen
T
T
Department of Neurology, VU Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
Kalkers
N F
NF
Crusius
J B A
JB
van Winsen
L
L
Barkhof
F
F
Jongen
P J H
PJ
Peña
A S
AS
Polman
C H
CH
Uitdehaag
B M J
BM
D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D053222:Fas Ligand Protein; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors; D019014:fas Receptor / Q000235:genetics* / Q000276:immunology
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor; D016899:Interferon-beta