Lack of association between intussusception and oral polio vaccine in Cuban children.
Two exploratory investigations found an increased risk of intussusception after oral polio vaccine (OPV). A large, national, population-based study was undertaken in Cuba to investigate a possible association. Three hundred and thirty-five cases of intussusception in children under 2 years of age occurring in 1995-2000 were identified and their OPV records retrieved. The relative incidence (RI) of intussusception in defined periods up to 42 days after OPV in children under 1 year was estimated using the self-controlled case series method, controlling for age and season. The RI was not significantly raised in any of the time intervals examined within the 0-42 day period after OPV. For the period 0-42 days as a whole the RI was 1.11, 95% CI 0.74-1.67. This study does not support the hypothesis that OPV causes intussusception.
Sardiñas
M A
MA
Direccion Nacional de Epidemiologia, MINSAP, Ciudad de la Habana, Cuba.
Cárdenas
A Z
AZ
Marie
G C
GC
Peña
M S
MS
Santiago
M A
MA
Sanchez
M V
MV
Farrington
C P
CP
D003462:Cuba / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D011051:Poliomyelitis / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D012307:Risk Factors
D011055:Poliovirus Vaccine, Oral