17Beta-estradiol stimulates regeneration of sciatic nerve in female mice.
In ovariectomized mice with and without estrogen replacement, regeneration of the sciatic nerve after crush injury was studied. Functional recovery, quantified with sciatic functional index was significantly accelerated in estrogen-treated mice throughout the regeneration. On semi-thin sections of sciatic nerves in estrogen-treated mice we registered a greater total number of regenerating nerve fibers at the first week, and a higher mean axonal area at the third week of regeneration. Our results demonstrated that estrogen treatment enhances regeneration of the sciatic nerve.
Islamov
Rustem R
RR
Department of Physiology, The Brody School of Medicine, East Carolina University, 600 Moye Blvd., Greenville, NC 27858, USA.
Hendricks
Wesley A
WA
Jones
Robert J
RJ
Lyall
Gregory J
GJ
Spanier
Nicole S
NS
Murashov
Alexander K
AK
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002452:Cell Count; D003714:Denervation; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009414:Nerve Growth Factors / Q000097:blood / Q000494:pharmacology; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology*; D018696:Neuroprotective Agents / Q000097:blood / Q000494:pharmacology*; D020127:Recovery of Function / Q000187:drug effects* / Q000502:physiology; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D020426:Sciatic Neuropathy / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D012737:Sex Factors
D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D004958:Estradiol