Radiotherapy-induced cerebral abnormalities in patients with low-grade glioma.
Abnormalities on CT or MRI and neuropsychological performance in patients with low-grade glioma, with (n = 23) or without (n = 16) prior cerebral radiotherapy, were evaluated. Cerebral atrophy was observed in 14 of 23 patients (61%) treated with prior radiotherapy, and in 1 of 16 patients (6%) without prior radiotherapy. White matter abnormalities were observed in six patients, all of whom were treated with prior radiotherapy. These radiologic cerebral abnormalities correlated with cognitive performance.
Postma
T J
TJ
Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. TJ.Postma@vumc.nl
Klein
M
M
Verstappen
C C P
CC
Bromberg
J E C
JE
Swennen
M
M
Langendijk
J A
JA
Taphoorn
M J B
MJ
Scheltens
P
P
Slotman
B J
BJ
van der Ploeg
H M
HM
Aaronson
N K
NK
Heimans
J J
JJ
D000328:Adult; D001284:Atrophy; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D002540:Cerebral Cortex / Q000473:pathology*; D003071:Cognition; D005260:Female; D005910:Glioma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*