A new translocation t(11;13)(q13;q14) in a mature B-cell neoplasm.
We present the case of a man affected by an unclassified mature B-cell neoplasm with a bone marrow culture stimulated with TPA showing a 46,XY, t(11;13)(q13;q14)[14]/46,XY [6] karyotype. Fluorescent in situ hybridization demonstrated that the BCL1 oncogene is translocated (not rearranged) to chromosome band 13q14 and that a copy of D13S319 locus is deleted. To our knowledge, this is the first reported case with this novel cytogenetic aberration.
Solé
Francesc
F
Salido
Marta
M
Espinet
Blanca
B
Zamora
Lurdes
L
Berlanga
Joan
J
Domingo
Alicia
A
D001402:B-Lymphocytes / Q000473:pathology; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D019938:Cyclin D1 / Q000235:genetics; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
D019938:Cyclin D1