[Congenital renal defects from 1961 to 2000--incidence, prenatal diagnosis and prevalence according to maternal age].
OBJECTIVE
Presentation of agenesis/hypoplasia of kidneys and cystic kidneys in the Czech Republic during 1961-2000. Analysis of prevalence of these defects in different groups by maternal age.


METHODS
Retrospective demographic-epidemiological study.


METHODS
Institute for the Care of Mother and Child, Prague.


METHODS
The author used data from the nationwide register of birth defects in neonates, kept by the Institute of Health Information and Statistics in the CR during 1990-2000. Epidemiological analysis of the incidence of agenesis/hypoplasia of the kidneys and cystic kidneys in the CR during 1961 to 2000 in cases diagnosed prenatally and in born children. The authors made a mathematical-statistical analysis of the prevalence of these defects by maternal age, using the method of calculation of the 95% confidence interval of probability.


RESULTS
In the CR there were during the period from 1961-2000 1093 registered cases of agenesis/hypoplasia of the kidneys and 1370 cases of cystic kidneys. The mean incidence during the entire period was 1.81 in agenesis/hypoplasia of the kidneys and 2.26 in cystic kidneys per 10,000 live born infants. After adding prenatally diagnosed cases and pregnancies terminated on that account it was 2.05 a 2.58 per 10,000 live born infants.


CONCLUSIONS
The investigation of these inborn defects did not confirm nor rule out statistically a higher risk of women older than the population average.
Sípek
A
A
Ustav pro péci o matku a dítĕ, Praha-Podolí.
Gregor
V
V
Horácek
J
J
Masátová
D
D
D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D008423:Maternal Age; D011247:Pregnancy; D011296:Prenatal Diagnosis; D015995:Prevalence; D012189:Retrospective Studies