title: Effects of fluoride release from bis-GMA/TEGDMA resin regulated by gamma-methacryloxypropyltrimethoxysilane on demineralization of bovine enamel.
abstract: We previously demonstrated that fluoride release from resins could be regulated by the polysiloxane coating of the fluoride additives. The present study investigated the effects of regulated fluoride release from resin on enamel demineralization in vitro. Bovine enamel cavities were restored with bis-GMA/TEGDMA resins containing 50 wt% NaF powders treated with or without gamma-methacryloxypropyltrimethoxysilane. Specimens were immersed in distilled water that was changed daily to measure the amount of fluoride released over 40 days, and thereafter subjected to pH-cycling. Microradiographic observations were performed to determine total mineral loss (AZ) and lesion depth (Ld) on the enamel. In addition, fluorine distribution was analyzed using EPMA. The resin containing untreated NaF exhibited high-rate and short-term fluoride release, whereas the resin containing treated NaF released low concentrations of fluoride over a longer period. The former showed high fluorine uptake in the adjacent enamel. In contrast, the latter showed high fluorine uptake not only in the adjacent enamel, but also in a wider area of enamel surface. The latter also showed lower AZ and Ld values in the surrounding enamel, indicating a high inhibitory effect on caries formation. Therefore, it is suggested that regulated fluoride release from the resin based on polysiloxane coating is effective in preventing caries formation.
authors.affiliation: Department of Operative Dentistry, Okayama University Graduate School of Medicine and Dentistry, Japan. nakabo@md.okayama-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakabo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Torii
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Itota
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Koji
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshiyama
mesh_terms: D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate; D002417:Cattle; D003188:Composite Resins; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism*; D005459:Fluorides / Q000378:metabolism* / Q000494:pharmacology*; D011092:Polyethylene Glycols; D011109:Polymethacrylic Acids; D012969:Sodium Fluoride
chemical_list: D003188:Composite Resins; D011109:Polymethacrylic Acids; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate; D012969:Sodium Fluoride; D005459:Fluorides