title: Levels of lipid peroxidation products in a chronic inflammatory disorder.
abstract: We have examined the plasma levels of the lipid peroxidation products 4-hydroxy-nonenal and malondialdehyde in a carefully controlled study of age and sex-matched subjects with rheumatoid arthritis in whom potentially confounding influences such as disease modifying anti-rheumatic drugs (DMARDs), self-medication and vitamin supplements were eliminated. The plasma concentrations of the antioxidants uric acid and vitamin E were also measured. The results reveal a strong and consistent inverse correlation between the levels of lipid peroxidation products in the plasma and erythrocyte sedimentation rate (ESR). There is no indication that vitamin E or urate function as the major antioxidant agent in arthritis, as has been suggested in more seriously affected patients. It is concluded that there is no evidence that vitamin E is more important, and urate less important as an antioxidant in mild arthritis. The correlation between lipid peroxidation and ESR suggests a more complex relationship than has been assumed.
authors.affiliation: Institute of Biomedical & Life Sciences, University of Glasgow, UK.
authors.forename: C L
authors.initials: CL
authors.lastname: Deaney
authors.forename: K
authors.initials: K
authors.lastname: Feyi
authors.forename: C M
authors.initials: CM
authors.lastname: Forrest
authors.forename: A
authors.initials: A
authors.lastname: Freeman
authors.forename: G
authors.initials: G
authors.lastname: Harman
authors.forename: M S
authors.initials: MS
authors.lastname: McDonald
authors.forename: A
authors.initials: A
authors.lastname: Petrie
authors.forename: S J
authors.initials: SJ
authors.lastname: Shaw
authors.forename: T W
authors.initials: TW
authors.lastname: Stone
authors.forename: N
authors.initials: N
authors.lastname: Stoy
authors.forename: L G
authors.initials: LG
authors.lastname: Darlington
mesh_terms: D000328:Adult; D000447:Aldehydes / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000447:Aldehydes; D014810:Vitamin E; D014527:Uric Acid; D008315:Malondialdehyde; C027576:4-hydroxy-2-nonenal