Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response.
The molecular bases of Mycobacterium tuberculosis pathogenicity remain unclear. We report here how M. tuberculosis mannosylated lipoarabinomannans contribute to the survival of bacilli in the human reservoir by (i) inhibiting IL-12 production by macrophages and dendritic cells and (ii) modulating M. tuberculosis-induced macrophage apoptosis.
Nigou
Jérôme
J
Institut de Pharmacologie et de Biologie Structurale, CNRS, 205 route de Narbonne, Toulouse, France.
Gilleron
Martine
M
Rojas
Mauricio
M
García
Luis F
LF
Thurnher
Martin
M
Puzo
Germain
G
D000942:Antigens, Bacterial / Q000276:immunology*; D017209:Apoptosis; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D014376:Tuberculosis / Q000276:immunology*
D000942:Antigens, Bacterial; D016207:Cytokines; D008070:Lipopolysaccharides; D011956:Receptors, Cell Surface; C050016:lipoarabinomannan