title: [Comparative analysis of quantitative evaluation methods for FDG-PET scans].
abstract: The comparative analysis of two kinetic methods most frequently applied for the quantization of the results of FDG-PET brain scans was performed applying PET investigations and computer simulations. The analysis of the measured data and computer simulation demonstrated that the applicability of the results of SUV-methods to estimate glucose metabolic rates (GMR) as calculated by the Phelps-method (the most advanced method ) depended on the selected cerebral region. The distorted estimation was explained by the fact that the simpler models neglect dephosphorylation of the FDG-6P, and they also disregard the contribution of the intravascular activity to the tissue radioactivity. The simulations revealed the lack of a general and close positive correlation between SUV and GMR data; under special circumstances they might even change in an inverse manner.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, PET Centrum, Debrecen. balkay@pet.dote.hu
authors.forename: László
authors.initials: L
authors.lastname: Balkay
authors.forename: Zoárd
authors.initials: Z
authors.lastname: Krasznai
authors.forename: Pál
authors.initials: P
authors.lastname: Mikecz
mesh_terms: D003198:Computer Simulation; D005069:Evaluation Studies as Topic; D019788:Fluorodeoxyglucose F18; D006801:Humans; D015233:Models, Statistical; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18