title: Prediction of human protein function from post-translational modifications and localization features.
abstract: We have developed an entirely sequence-based method that identifies and integrates relevant features that can be used to assign proteins of unknown function to functional classes, and enzyme categories for enzymes. We show that strategies for the elucidation of protein function may benefit from a number of functional attributes that are more directly related to the linear sequence of amino acids, and hence easier to predict, than protein structure. These attributes include features associated with post-translational modifications and protein sorting, but also much simpler aspects such as the length, isoelectric point and composition of the polypeptide chain.
authors.affiliation: Center for Biological Sequence Analysis, Biocentrum-DTU, Building 208, The Technical University of Denmark, DK-2800 Lyngby, Denmark.
authors.forename: L J
authors.initials: LJ
authors.lastname: Jensen
authors.forename: R
authors.initials: R
authors.lastname: Gupta
authors.forename: N
authors.initials: N
authors.lastname: Blom
authors.forename: D
authors.initials: D
authors.lastname: Devos
authors.forename: J
authors.initials: J
authors.lastname: Tamames
authors.forename: C
authors.initials: C
authors.lastname: Kesmir
authors.forename: H
authors.initials: H
authors.lastname: Nielsen
authors.forename: H H
authors.initials: HH
authors.lastname: Staerfeldt
authors.forename: K
authors.initials: K
authors.lastname: Rapacki
authors.forename: C
authors.initials: C
authors.lastname: Workman
authors.forename: C A F
authors.initials: CA
authors.lastname: Andersen
authors.forename: S
authors.initials: S
authors.lastname: Knudsen
authors.forename: A
authors.initials: A
authors.lastname: Krogh
authors.forename: A
authors.initials: A
authors.lastname: Valencia
authors.forename: S
authors.initials: S
authors.lastname: Brunak
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D004798:Enzymes / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D015894:Genome, Human; D006031:Glycosylation; D006801:Humans; D007526:Isoelectric Point; D008037:Linguistics; D016571:Neural Networks, Computer; D010766:Phosphorylation; D020161:Physical Chromosome Mapping; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry* / Q000145:classification* / Q000378:metabolism; D012984:Software
chemical_list: D004798:Enzymes; D021382:Protein Sorting Signals; D011506:Proteins