Handedness of the herpes simplex virus capsid and procapsid.
The capsid of herpes simplex virus has an icosahedral surface lattice with a nonskew triangulation number, T=16. Nevertheless, the proteins arrayed on this lattice necessarily have an intrinsic handedness. We have determined the handedness of both the herpes simplex virus type 1 capsid and its precursor procapsid by a cryoelectron microscopic tilting method.
Cheng
Naiqian
N
Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Trus
Benes L
BL
Belnap
David M
DM
Newcomb
William W
WW
Brown
Jay C
JC
Steven
Alasdair C
AC
D002213:Capsid / Q000737:chemistry*; D020285:Cryoelectron Microscopy / Q000379:methods; D008958:Models, Molecular; D011498:Protein Precursors / Q000737:chemistry*; D018139:Simplexvirus / Q000737:chemistry*; D013237:Stereoisomerism
D011498:Protein Precursors