title: Breast cancer detection: evaluation of a mass-detection algorithm for computer-aided diagnosis -- experience in 263 patients.
abstract: OBJECTIVE
  To evaluate the performance of a computer-aided diagnosis (CAD) mass-detection algorithm in marking preoperative masses.
  
  
  METHODS
  Digitized mammograms were processed with an adaptive enhancement filter followed by a local border refinement stage. Features were then extracted from each detected structure and used to identify potential masses. The performance of the algorithm was evaluated in independent cases obtained from 263 patients from two institutions. Each case contained one or more pathologically proved breast masses. Contralateral mammograms obtained in the same patients that did not contain a visible lesion were used to estimate the CAD marker rate for the algorithm. The tradeoff between detection sensitivity and the number of CAD marks was analyzed in this study.
  
  
  RESULTS
  Malignant masses were detected with the computer in 87% (135 of 156), 83% (130 of 156), and 77% (120 of 156) of the malignant cases at CAD marker rates of 1.5, 1.0, and 0.5 marks per mammogram, respectively. The difference between malignant mass-detection performance in subsets of cases collected at each institution was found to be less than 1%. The detection accuracy for benign masses was lower than that for malignant masses.
  
  
  CONCLUSIONS
  This mass-detection algorithm had a high sensitivity for detection of malignant masses. It may be useful as a second opinion in mammographic interpretation.
authors.affiliation: Department of Radiology, University of Michigan Medical Center, CGC B2102, Box 0904, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0904. From the 2001 RSNA scientific assembly. Received June 18, 2001.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Petrick
authors.forename: Berkman
authors.initials: B
authors.lastname: Sahiner
authors.forename: Heang-Ping
authors.initials: HP
authors.lastname: Chan
authors.forename: Mark A
authors.initials: MA
authors.lastname: Helvie
authors.forename: Sophie
authors.initials: S
authors.lastname: Paquerault
authors.forename: Lubomir M
authors.initials: LM
authors.lastname: Hadjiiski
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D011856:Radiographic Image Enhancement; D012680:Sensitivity and Specificity