title: Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.
abstract: We report an unusual case of a leiomyosarcoma of the urinary bladder after chemotherapy for retinoblastoma and the results of a review of the published reports of bladder sarcomas. A 22-year-old man presented with hematuria and was found to have a mass in his urinary bladder on computed tomography. Transurethral resection of the mass revealed a leiomyosarcoma. The patient underwent radical cystectomy and an ileal conduit was created. The final pathologic examination confirmed high-grade leiomyosarcoma. Prospective randomized combination trials similar to the Intergroup Rhabdomyosarcoma Study in the pediatric population are necessary to better understand and manage these potentially curable sarcomas.
authors.affiliation: Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2765, USA.
authors.forename: Dipen J
authors.initials: DJ
authors.lastname: Parekh
authors.forename: Charlie
authors.initials: C
authors.lastname: Jung
authors.forename: Jeffery
authors.initials: J
authors.lastname: O'Conner
authors.forename: Sajal
authors.initials: S
authors.lastname: Dutta
authors.forename: Ernest R
authors.initials: ER
authors.lastname: Smith
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use*; D015653:Cystectomy / Q000379:methods; D006417:Hematuria / Q000175:diagnosis; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D011379:Prognosis; D019572:Retinal Neoplasms / Q000188:drug therapy*; D012175:Retinoblastoma / Q000188:drug therapy*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014547:Urinary Diversion / Q000379:methods
chemical_list: D003520:Cyclophosphamide