Proconvulsive effect of the GABA(B) receptor antagonist, SCH 50911, in rats undergoing ethanol withdrawal syndrome.
The present study investigated the effect of the GABA(B) receptor antagonist, SCH 50911 [(2S)(+)-5,5-dimethyl-2-morpholineacetic acid], on the occurrence of seizures in ethanol-dependent rats undergoing ethanol withdrawal syndrome. The acute administration of nonconvulsive doses of SCH 50911 (0, 100, 170 and 300 mg/kg, i.p.) resulted in a dramatic facilitation of spontaneous seizure occurrence. This finding, together with the reported ability of the GABA(B) receptor agonist, baclofen, to suppress seizures associated to ethanol withdrawal syndrome, suggests that the GABA(B) receptor may be part of the neural substrate underlying the hyperexcitability of ethanol withdrawal syndrome.
Carai
Mauro A M
MA
Neuroscienze S.c.a r.l., Via Palabanda 9, I-09123 Cagliari (CA), Italy.
Brunetti
Giuliana
G
Lobina
Carla
C
Serra
Salvatore
S
Vacca
Giovanni
G
Minardi
Giovanna
G
Colombo
Giancarlo
G
Gessa
Gian Luigi
GL
D020270:Alcohol Withdrawal Seizures / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D003292:Convulsants / Q000009:adverse effects*; D000431:Ethanol / Q000009:adverse effects*; D018756:GABA Antagonists / Q000009:adverse effects*; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D008297:Male; D009025:Morpholines / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D018080:Receptors, GABA-B / Q000502:physiology
C095804:(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid; D003292:Convulsants; D018756:GABA Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D009025:Morpholines; D018080:Receptors, GABA-B; D000431:Ethanol