title: Acute thrombotic obstruction of mitral valve prosthesis: low protein C level.
abstract: A 51-year-old female underwent redo mitral valve replacement with a pericardial bioprosthesis because of acute thrombotic obstruction of a mechanical valve, in spite of adequate anticoagulation with warfarin. Her protein C level was 24% of the normal value and protein S was reduced to 54% of normal.
authors.affiliation: Department of Cardiovascular Surgery, Osaka Police Hospital, Osaka, Japan. tohata@aol.com
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ohata
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takano
authors.forename: Toru
authors.initials: T
authors.lastname: Ishizaka
mesh_terms: D000208:Acute Disease; D000925:Anticoagulants / Q000627:therapeutic use; D001705:Bioprosthesis; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011486:Protein C / Q000032:analysis*; D012008:Recurrence; D012086:Reoperation; D012214:Rheumatic Heart Disease / Q000097:blood / Q000601:surgery*; D013923:Thromboembolism / Q000209:etiology* / Q000517:prevention & control; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D011486:Protein C; D014859:Warfarin