title: [Morphological study of osteosarcomas in children].
abstract: Osteosarcoma is the most frequent primary osteal tumor in children. Our study evaluates morphological aspects of osteosarcomas during last 20 years. We present the results of study that includes 32 cases of classical osteosarcomas that had been diagnosed and treated at the "Sf. Maria" Hospital from Iasi (Romania). The diagnosis is based on usually histopathological methods applied to bioptic and surgical exeresis pieces. Male sex is most involved (56%). Patients' age is between 12-15 years in 68% of total cases. In 50% cases the tumour was localized in distal femoral metaphysis. Histological forms were: osteoblastic (66%), chondroblastic (18%), fibroblastic (16%). Enneking's staging was: II A (6.25%), II B (81.25%), and III (12.5%). Metastasis appeared in 75% cases' evolution. Concluding, 25% of studied patients had a favourable evolution during a 5 years period. Survival rate at 2 years was 39%.
authors.affiliation: Disciplina Morfopatologie, Facultatea de Medicină Stomatologică, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
authors.forename: P
authors.initials: P
authors.lastname: Plămădeală
authors.forename: D
authors.initials: D
authors.lastname: Mihăilă
authors.forename: G
authors.initials: G
authors.lastname: Strugariu
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors