Myoclonic involuntary movement associated with chronic manganese poisoning.
We report a 17-year-old man showing myoclonic involuntary movement (IVM) associated with chronic manganese (Mn) poisoning. The patient, a welder, showed myoclonic IVM mainly in the right upper and lower extremities, elevated levels of Mn in the blood and hair and high-intensity signals in the globus pallidus on T1-weighted MR images. Chelation therapy resulted in improvement of the myoclonic IVM and MRI abnormalities. This is the first report of Mn poisoning characterized by myoclonic IVM without parkinsonism.
Ono
Kenjiro
K
Department of Neurology and Neurobiology of Aging, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan.
Komai
Kiyonobu
K
Yamada
Masahito
M
D000293:Adolescent; D001921:Brain / Q000473:pathology; D002614:Chelating Agents / Q000627:therapeutic use; D004569:Electroencephalography; D004576:Electromyography; D005917:Globus Pallidus / Q000473:pathology; D006197:Hair / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese / Q000032:analysis / Q000097:blood; D020149:Manganese Poisoning / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009207:Myoclonus / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D016273:Occupational Exposure
D002614:Chelating Agents; D008345:Manganese