[Pulmonary sarcoidosis in a case of dermatomyositis under long-term steroid therapy].
Pulmonary sarcoidosis in association with dermatomyositis has rarely been reported. A 52-year-old woman was admitted for evaluation of a previously unrecognized bilateral hilar lymphadenopathy on a chest radiogram in August 1995. She had been receiving oral corticosteroids for dermatomyositis, which was confirmed by the typical skin rash and the myogenic changes on an electromyogram in 1977. She had no respiratory symptoms at the time of admission. Chest computed tomography showed hilar and mediastinal lymphadenopathy with reticular shadows in the peripheral lung parenchyma. A 67gallium-citrate scintigram apparently revealed accumulation in bilateral hilums. The tuberculin skin reaction was negative. Flowcytometry of bronchoalveolar lavage fluid indicated a CD4/CD8 ratio of 5.37. Thoracoscopic biopsy specimens sampled from the mediastinal lymph nodes and the lung demonstrated non-caseating granulomas. A definitive diagnosis of pulmonary sarcoidosis was made from these findings. The chest radiographic findings were spontaneously resolved after three years with no increase in the dosage of oral corticosteroids. It is well known that an abnormal immune response playa an important role in development of dermatomyositis and sarcoidosis. This case suggested close associations in both diseases.
Yamamoto
Yasushi
Y
First Department of Medicine, Asahikawa Medical College, 2-1-1-1, Midorigaoka-Higashi, Asahikawa 078-8510.
Ide
Hiroshi
H
Nishigaki
Yutaka
Y
Fujiuchi
Satoru
S
Akiba
Yuji
Y
Osanai
Shinobu
S
Nakano
Hitoshi
H
Ohsaki
Yoshinobu
Y
Kikuchi
Kenjiro
K
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*; D017565:Sarcoidosis, Pulmonary / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D011239:Prednisolone