title: Indications and results of surgery in patients with Crohn's disease with onset under 10 years of age: a series of 18 patients.
abstract: In order to examine the presentation and course of Crohn's disease (CD) with an onset of CD before the age of 10 and to assess indications and effects of surgery, a retrospective study was performed in 18 children. One hundred and twenty-two children with CD have been followed over the last 22 years in our institution. Thirty of them had the first onset of disease before 10 years of age. Eighteen out of these 30 underwent intestinal resection (IR). The mean age at the onset of CD was 6.4 years and the average duration of follow-up was 11.1 years. Most common symptoms were abdominal pain (72 %), diarrhoea (72 %), and growth retardation (50 %). Colon and ileum were the most frequently involved areas. Most of the children (94.5 %) received extensive medical and or nutritional treatment before surgery. We performed 26 IRs and 14 other operations in 18 patients. Indications for IR were chronic intestinal obstruction (13 cases) and chronic intestinal disability (13 cases). Improvements in the general clinical state were obtained in 17 cases out of 18. IR is beneficial for chronically ill children with ineffective medical therapy. A disease-free interval after surgery may provide an important time for improved growth and pubertal development and a return to nearly normal life for a long time.
authors.affiliation: Paediatric Surgery Department, Hôpital des Enfants Malades, Paris, France.
authors.forename: A I
authors.initials: AI
authors.lastname: Dokucu
authors.forename: S
authors.initials: S
authors.lastname: Sarnacki
authors.forename: J L
authors.initials: JL
authors.lastname: Michel
authors.forename: D
authors.initials: D
authors.lastname: Jan
authors.forename: O
authors.initials: O
authors.lastname: Goulet
authors.forename: C
authors.initials: C
authors.lastname: Ricour
authors.forename: C
authors.initials: C
authors.lastname: Nihoul-Fekété
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D003424:Crohn Disease / Q000453:epidemiology / Q000601:surgery* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome