title: Gamma-probe-directed lymphatic mapping and sentinel lymphadenectomy in primary cutaneous melanoma.
abstract: BACKGROUND
  Radiotracer and blue-dye lymphatic mapping is a recommended combined method to guide sentinel lymphadenectomy and full regional lymph node dissection in selected patients with cutaneous melanoma.
  
  
  OBJECTIVE
  To evaluate the diagnostic accuracy and the prognostic value of gamma-probe-directed lymphatic mapping in cutaneous melanomas.
  
  
  METHODS
  Sixty-five stage I and II melanoma patients underwent gamma-probe-directed lymphatic mapping. Sentinel lymph nodes were studied by both conventional and immunohistochemical stainings. The median follow-up was 11 months.
  
  
  RESULTS
  Sensitivities of preoperative and intraoperative sentinel lymph node detection were 100 and 98%, respectively. Only 1 failure of detection and 1 missed same-basin metastasis were experienced in the axillary and cervical areas, respectively. Eleven patients (16.9%) had sentinel node metastases leading to adjuvant therapy.
  
  
  CONCLUSIONS
  Gamma-probe-directed lymphatic mapping is useful for staging melanoma. However, in the expectation of a more specific identification of the sentinel lymph node, the standard protocol remains recommended for exploring the axillary and cervical areas. The histological examination supported in some cases by immunohistochemistry remains mandatory in all cases.
authors.affiliation: Division of Nuclear Medicine, University of Liège, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Belhocine
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
authors.forename: J L
authors.initials: JL
authors.lastname: Gielen
authors.forename: F
authors.initials: F
authors.lastname: Daenen
authors.forename: C
authors.initials: C
authors.lastname: De Barsy
authors.forename: J E
authors.initials: JE
authors.lastname: Arrese
authors.forename: T
authors.initials: T
authors.lastname: Lahaye
authors.forename: P
authors.initials: P
authors.lastname: Rigo
mesh_terms: D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000556:secondary; D008875:Middle Aged; D011379:Prognosis; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology*; D016019:Survival Analysis