title: Therapeutic potential of implanted tissue-engineered bioartificial muscles delivering recombinant proteins to the sheep heart.
abstract: Tissue-engineered primary adult sheep muscle cells genetically engineered to express either rhVEGF or rhIGF-1 secreted the bioactive proteins locally in the sheep heart for at least 30 days.
authors.affiliation: Department of Pathology, Brown University School of Medicine and Miriam Hospital, Providence, RI 02906, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
authors.forename: J
authors.initials: J
authors.lastname: Shansky
authors.forename: M
authors.initials: M
authors.lastname: Del Tatto
authors.forename: P
authors.initials: P
authors.lastname: Ferland
authors.forename: S
authors.initials: S
authors.lastname: McGuire
authors.forename: J
authors.initials: J
authors.lastname: Marszalkowski
authors.forename: M
authors.initials: M
authors.lastname: Maish
authors.forename: R
authors.initials: R
authors.lastname: Hopkins
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Kosnik
authors.forename: M
authors.initials: M
authors.lastname: Nackman
authors.forename: A
authors.initials: A
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Creswick
authors.forename: H
authors.initials: H
authors.lastname: Vandenburgh
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D016228:Endothelial Growth Factors / Q000096:biosynthesis / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000235:genetics; D008222:Lymphokines / Q000096:biosynthesis / Q000235:genetics; D018482:Muscle, Skeletal / Q000166:cytology; D009132:Muscles / Q000166:cytology*; D009206:Myocardium / Q000166:cytology*; D018919:Neovascularization, Physiologic; D011994:Recombinant Proteins / Q000378:metabolism; D012756:Sheep; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D001672:Biocompatible Materials; D016228:Endothelial Growth Factors; D008222:Lymphokines; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D007334:Insulin-Like Growth Factor I