IGF2 genotype and obesity in men and women across the adult age span.
We studied a previously reported association between the IGF2 gene's ApaI polymorphism and obesity in 500 healthy men and women (19-90 y). We hypothesized that individuals homozygous for the IGF2 A allele (A/A) would exhibit lower body mass, BMI and DEXA-measured fat mass compared to G/G homozygotes. Subjects were categorized as exhibiting the G/G (n = 241), G/A (n = 197) or A/A (n = 62) genotype. Contrary to our hypothesis, no difference was observed in body mass, body mass index (BMI) or fat mass between the G/G and A/A genotype groups in the entire cohort. Surprisingly, Caucasian A/A individuals (n = 427) exhibited significantly higher fat mass compared to Caucasian G/G individuals (P < 0.05). In summary, individuals homozygous for the IGF2 G allele do not exhibit higher body mass, BMI or fat mass compared to A/A individuals; however, Caucasians with the A/A genotype exhibit higher fat mass than G/G individuals.
Roth
S M
SM
Department of Human Genetics, University of Pittsburgh, Pennsylvania 15261, USA. sroth@helix.hgen.pitt.edu
Schrager
M A
MA
Metter
E J
EJ
Riechman
S E
SE
Fleg
J L
JL
Hurley
B F
BF
Ferrell
R E
RE
D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000032:analysis / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics*
D007335:Insulin-Like Growth Factor II