Autoantibodies in autoimmune polyendocrine syndrome type II.
The autoimmune polyendocrine syndrome type II (APS-II) is characterized by the association of autoimmune Addison's disease with thyroid autoimmune diseases or type-1 diabetes mellitus. 21-Hydroxylase autoantibodies enable the accurate diagnosis of autoimmune Addison's disease and, in patients with other endocrine autoimmune diseases, identify subjects at high risk for clinical adrenal insufficiency. 17 alpha-Hydroxylase (17OH) and side-chain-cleavage enzyme (P450scc) are target autoantigens of steroid-cell autoantibodies, and in women with Addison's disease, 17OH autoantibodies and P450scc autoantibodies are markers of increased risk for premature ovarian failure. Thyroperoxidase autoantibodies, thyroglobulin autoantibodies, H+/K(+)-ATPase autoantibodies, and GAD65 autoantibodies are frequently detected in patients with isolated Addison's or APS-II. Screening for other organ-specific autoimmune diseases should be performed in every patient with at least one major disease component of APS-II.
Falorni
Alberto
A
Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, 06126 Perugia, Italy. falorni@dimisem.med.unipg.it
Laureti
Stefano
S
Santeusanio
Fausto
F
D000224:Addison Disease / Q000276:immunology; D000302:Adrenal Cortex / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D003922:Diabetes Mellitus, Type 1; D004064:Digestive System / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D010053:Ovary / Q000276:immunology; D010920:Placenta / Q000276:immunology; D016884:Polyendocrinopathies, Autoimmune / Q000276:immunology*; D013737:Testis / Q000276:immunology; D013959:Thyroid Diseases / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens