title: The effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia.
abstract: Neuropsychological deficits seem to be a major predictor of psychosocial outcome in patients with schizophrenia. Second-generation antipsychotics have shown greater promise in treating neuropsychological deficits than conventional antipsychotic drugs. This article summarizes the effect of newer antipsychotics on cognitive functioning and the implications for functional outcome. In this context it also addresses several methodological and conceptional issues that limited the comparison of these studies.
authors.affiliation: Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck University Clinics, Anichtrasse 35, 6020 Innsbruck, Austria. elisabeth.weiss@uibk.ac.at
authors.forename: Elisabeth M
authors.initials: EM
authors.lastname: Weiss
authors.forename: Robert M
authors.initials: RM
authors.lastname: Bilder
authors.forename: W Wolfgang
authors.initials: WW
authors.lastname: Fleischhacker
mesh_terms: D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents