Tachykinin receptor antagonists in irritable bowel syndrome.
Tachykinins (TKs) are abundantly expressed in the gastrointestinal (GI) tract in intrinsic excitatory motor neurons, interneurons, sensory neurons and extrinsic sensory neurons. Their role in the regulation of enteric secretomotor functions is well established, especially following pathophysiological stimuli. Recent evidence emphasizes the role of TKs in the sensitization of peripheral branches of visceral afferent neurons, implying a role in determining visceral hypersensitivity. Furthermore, the involvement of both CNS and peripheral TK receptors in autonomic reactions to stress, render these receptors an appealing target for the development of drugs aimed at the treatment of irritable bowel syndrome (IBS), a functional GI disorder. The available preclinical evidence indicates that TK receptor antagonists could normalize motor disturbance (diarrhea and constipation) and reduce the painful symptoms that characterize IBS.
Lecci
Alessandro
A
Pharmacology Department, Menarini Ricerche, Firenze, Italy. alecci@menarini-ricerche.it
Valenti
Claudio
C
Maggi
Carlo Alberto
CA
D000818:Animals; D002986:Clinical Trials as Topic; D003109:Colonic Diseases, Functional / Q000378:metabolism / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000502:physiology; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors* / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology; D014781:Viscera / Q000503:physiopathology
D018039:Receptors, Tachykinin