[Morphofunctional changes in the spinal cord and spinal ganglion tissues following epidural injection of clopheline].
Epidural injection of clophelin extends the possibilities and increases of the effectiveness of regional anesthesia in clinical treatment of pain syndromes. Morphological and histoenzymological changes in spinal cord and spinal ganglion neurons were analyzed in dogs after epidural injection of clophelin. The results indicate the absence of pathological structural and metabolic changes in nervous tissue following clophelin administration. Increase in neuronal RNA content and microvascular alkaline phosphatase activity in experimental group as compared to the control one indicates the activation of protein synthesis and the augmentation of active transport processes in the nervous tissue capillary endothelium, both of which may be interpreted as the favorable phenomena.
Volchkov
V A
VA
Department of Anesthesiology and Reanimatology, Laboratory of Pathologic Morphology of Scientific Research Center, I.P. Pavlov State Medical University, St.-Petersburg.
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D003000:Clonidine / Q000008:administration & dosage*; D004285:Dogs; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006651:Histocytochemistry; D007268:Injections, Epidural; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D000700:Analgesics; D003000:Clonidine