[Physiologic significance of the interaction between timolol and free amino acids in eye structures].
The authors analyze the interaction of timolol maleate (Timoptol, Léciva Prague) with free amino acids with regard to the effect on intraocular pressure. The different colour reaction of an amino acid mixture with Timoptol, the decline of radioactivity of Na[I125] tyrosine with Timoptol and the formation of 8 radioactive fractions after addition of Timoptol to Na[I125] indicate: a) the specificity of interaction of each amino acid with Timoptol; b) suggest that between Timoptol and free amino acids a firm covalent bond develops with the concurrent development of a new biologically active metabolite. Evidence of the presence of a new metabolite is important from the aspect of understanding and more accurate definition of the action of Timoptol in tissue structures of the eye and thus also for possible effective treatment of glaucoma.
Veselovský
J
J
Katedra zivocísnej fyziológie a etológie PrF UK, Bratislava, SR.
Oláh
Z
Z
Veselá
A
A
Gressnerová
S
S
D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D001345:Autoradiography; D002855:Chromatography, Thin Layer; D005123:Eye / Q000378:metabolism; D005902:Glaucoma, Open-Angle / Q000378:metabolism; D013999:Timolol / Q000737:chemistry* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D000596:Amino Acids; D013999:Timolol