The intracellular localization of the proteasome.
In summary, localization of proteasomes does appear to be important in the regulation of proteolysis. In yeast, a discrete localization is observed at the nuclear periphery for cells undergoing mitotic growth. This localization is clearly important as degradation by the ubiquitin/proteasome pathway is impaired in mutants that mislocalize proteasomes. In mammalian cells, proteasomes are present throughout the cell. However, the proteasome does appear to be enriched at the MTOC upon aggresome formation. The inhibition of the ubiquitin/proteasome pathway in aggresome-containing cells could provide an explanation for the pathogenicity of a number of neurodegenerative diseases.
Gordon
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MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
D000818:Animals; D002451:Cell Compartmentation; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000201:enzymology / Q000648:ultrastructure; D005656:Fungal Proteins / Q000378:metabolism; D046911:Macromolecular Substances; D008322:Mammals / Q000378:metabolism; D008540:Meiosis; D008938:Mitosis; D009097:Multienzyme Complexes / Q000378:metabolism*; D011387:Prokaryotic Cells / Q000201:enzymology / Q000648:ultrastructure; D046988:Proteasome Endopeptidase Complex; D021122:Protein Subunits; D015003:Yeasts / Q000201:enzymology / Q000648:ultrastructure
D005656:Fungal Proteins; D046911:Macromolecular Substances; D009097:Multienzyme Complexes; D021122:Protein Subunits; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex