Osteonectin-expressing cells in human stomach cancer and their possible clinical significance.
The clinical significance of osteonectin in human stomach cancer was examined immunohistochemically and molecular biologically in 31 differentiated and eight undifferentiated stomach adenocarcinomas and 19 non-cancer stomach tissues. Osteonectin-mAb-stained cells were observed in stroma of 90% differentiated and 63% undifferentiated adenocarcinomas, and of 26% non-cancer stomach tissues. Competitive reverse transcriptase polymerase chain reaction results generally coincided with immunohistochemical data. The present results suggest that osteonectin is highly expressed in reactive stroma associated with invasive differentiated adenocarcinomas and that it may serve as a useful clinical diagnostic marker for stomach cancer.
Maeng
Hack-Young
HY
Department of Life Science, University of Joong-Bu, Chungnam 312-702, South Korea.
Song
Seok Bean
SB
Choi
Dong-Kug
DK
Kim
Kyoon Eon
KE
Jeong
Hyun Young
HY
Sakaki
Yoshiyuki
Y
Furihata
Chie
C
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D015676:Osteonectin / Q000235:genetics / Q000378:metabolism*; D012334:RNA, Neoplasm; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D017931:DNA Primers; D015676:Osteonectin; D012334:RNA, Neoplasm