title: [Enzymatic markers in the alcoholic cardiomyopathy].
abstract: Alcoholic cardiomyopathy can ensue from heavy consumption of alcohol over a long period of time. The clinical features include dilatation of the left ventricle, poor myocardial contractility with reduced left ventricular ejection volume, raised tissue enzymes. In numerous experimental data has been observed increased generation of oxygen and ethanol free radicals, indicate that free radicals are implied in myocardial and hepatic damage. Ethanol administration also elicits hepatic disturbances in the availability of antioxidant defense. The resulting antioxidative stress leads to enhanced lipid peroxidation and can also affect other important cellular component.
authors.affiliation: Disciplina de Biochimie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
authors.forename: I
authors.initials: I
authors.lastname: Popovici
authors.forename: C
authors.initials: C
authors.lastname: Rezuş
authors.forename: A
authors.initials: A
authors.lastname: Cosovanu
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000032:analysis; D002310:Cardiomyopathy, Alcoholic / Q000201:enzymology* / Q000473:pathology; D000431:Ethanol / Q000009:adverse effects; D005609:Free Radicals / Q000032:analysis; D006519:Hepatitis, Alcoholic / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008315:Malondialdehyde / Q000032:analysis*; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D013482:Superoxide Dismutase / Q000032:analysis*; D005723:gamma-Glutamyltransferase / Q000032:analysis*
chemical_list: D005609:Free Radicals; D000431:Ethanol; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases