title: Aceriphyllic acid A, A new ACAT inhibitory triterpenoid, from Aceriphyllum rossii.
abstract: Two new triterpenoids along with three known ones, 3-oxoolean-12-en-27-oic acid (1), 3alpha-hydroxyolean-12-en-27-oic acid (2) and 3beta-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3alpha,23-dihydroxyolean-12-en-27-oic acid (4) and a 3alpha,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.
authors.forename: Jae-Taek
authors.initials: JT
authors.lastname: Han
authors.forename: Hae-Yeong
authors.initials: HY
authors.lastname: Kim
authors.forename: Young-Doo
authors.initials: YD
authors.lastname: Park
authors.forename: Youn-Hyung
authors.initials: YH
authors.lastname: Lee
authors.forename: Kang-Ro
authors.initials: KR
authors.lastname: Lee
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000097587:Sterol O-Acyltransferase 2
chemical_list: D010936:Plant Extracts; D002785:Sterol O-Acyltransferase; D014315:Triterpenes; D000097587:Sterol O-Acyltransferase 2; C465101:aceriphyllic acid A; C465102:aceriphyllic acid B