Spiroidesin, a novel lipopeptide from the cyanobacterium Anabaena spiroides that inhibits cell growth of the cyanobacterium Microcystis aeruginosa.
Spiroidesin (1), a novel D-amino acid-containing linear lipopeptide, was isolated from waterblooms of the cyanobacterium Anabaena spiroides. The structure was identified by 2D NMR and chemical degradation analyses. Spiroidesin inhibited cell growth of the toxic cyanobacterium Microcystis aeruginosa (IC(50), 1.6 x 10(-6) M).
Kaya
Kunimitsu
K
Laboratory of Intellectual Fundamentals for Environmental Studies, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan. kayakuni@nies.go.jp
Mahakhant
Aparat
A
Keovara
Ladda
L
Sano
Tomoharu
T
Kubo
Takuya
T
Takagi
Hiroo
H
D017033:Anabaena / Q000737:chemistry* / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D020128:Inhibitory Concentration 50; D055666:Lipopeptides; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D046931:Microcystis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides; D013785:Thailand
D000900:Anti-Bacterial Agents; D055666:Lipopeptides; D008074:Lipoproteins; D010455:Peptides; C464986:spiroidesin