title: Should gastric cancer patients more than 80 years of age undergo surgery? Comparison with patients not treated surgically concerning prognosis and quality of life.
abstract: This study investigated the performance status, mental status, and prognosis of 24 patients older than 80 years whose gastric cancer had been managed surgically during the past 6 years, and 21 patients who were observed conservatively. The advantages and disadvantages of surgery for elderly patients with gastric cancer is discussed. The 3-year survival rate for patients with advanced gastric cancer was 31% for those surgically treated and 0% for those observed conservatively. The difference is statistically significant. The survival rate for patients with early gastric cancer was 62.5% in the surgical treatment group and 33.3% in the conservative observation group, a difference that is not significant. Decline in performance status and deterioration of mental status after open surgery were slight, and the survival rate for patients treated surgically was significantly higher than for conservatively observed patients, regardless of performance status and whether mental status had deteriorated. On univariate and multivariate analyses, the presence or absence of open surgery and macroscopic classification were the only significant prognostic factors, whereas performance status and the presence or absence of mental deterioration were not significant prognostic factors. These results suggest that surgical treatment should not be discouraged even for patients older than 80 years.
authors.affiliation: First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan. matsushi@mail.wbs.ne.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Matsushita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hanai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kajimura
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Matsubayashi
authors.forename: Eizo
authors.initials: E
authors.lastname: Kanek
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006305:Health Status Indicators; D006801:Humans; D008603:Mental Health; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate