Mediating mechanisms for the impact of bupropion in smoking cessation treatment.
Several studies have documented the effectiveness of bupropion for smoking cessation, yet little is known about the mechanisms by which it facilitates abstinence. In this placebo-controlled randomized trial. We examined whether bupropion's effects on cessation were mediated by changes in withdrawal and/or negative or positive affect (PA). Two hundred and fifty-one smokers received 10-week treatment with bupropion or placebo, plus behavioral counseling. Changes in affect and withdrawal symptoms from pre-quit to 1 week post quit were examined as mediating variables in structural equation models. Cotinine-verified 7-day point prevalence cessation rates at the end of treatment (8-weeks post quit date) were 48% for bupropion and 29% for placebo (P=0.001). There were significant treatment effects on withdrawal and negative affect (NA); however, only change in NA predicted cessation. In a path model, change in NA was a significant mediator of bupropion's effects on cessation. However, the proportion of variance accounted for by this mediator was small, suggesting that other unmeasured factors play an important role. Laboratory-based paradigms may be useful to identify other mediators of bupropion's effects, thereby pointing to mechanisms of effect that can be bolstered in future treatment studies.
Lerman
Caryn
C
Cancer Center and Department of Psychiatry, University of Pennsylvania Health Sciences, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA. clerman@mail.med.upenn.edu
Roth
David
D
Kaufmann
Vyga
V
Audrain
Janet
J
Hawk
Larry
L
Liu
Aiyi
A
Niaura
Ray
R
Epstein
Leonard
L
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016642:Bupropion / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000188:drug therapy* / Q000523:psychology*; D016540:Smoking Cessation / Q000523:psychology* / Q000706:statistics & numerical data; D016896:Treatment Outcome
D016642:Bupropion