title: Binding efficiency and transport properties of molecularly imprinted polymer thin films.
abstract: A model system for the characterization of molecular recognition events in molecularly imprinted polymers (MIPs) is presented. The use of a biologically inspired, three-point hydrogen-bonding motif and a thin film polymeric matrix allows for pre- and post-polymerization binding properties to be characterized by infrared spectroscopy. A method to determine binding constants was developed and utilized before and after cross-linking. These values showed a 10-fold decrease in binding after polymerization, which was attributed to an increase in molecular confinement after polymerization and a change in the local structural environment of the binding cavity. Transport of the guest molecule was shown to be reversible.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Duffy
authors.forename: Kanad
authors.initials: K
authors.lastname: Das
authors.forename: Shaw L
authors.initials: SL
authors.lastname: Hsu
authors.forename: Jacques
authors.initials: J
authors.lastname: Penelle
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
authors.forename: Howard D
authors.initials: HD
authors.lastname: Stidham
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D007700:Kinetics; D018716:Molecular Mimicry; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D011409:Propylene Glycols / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013698:Templates, Genetic; D013816:Thermodynamics; D013941:Thymine / Q000031:analogs & derivatives*
chemical_list: D000179:Acrylates; D011108:Polymers; D011409:Propylene Glycols; D011725:Pyridines; C105815:tripropylene glycol diacrylate; D013941:Thymine