B-cell lymphoproliferative disorders.
The differential diagnosis of the B-cell lymphoproliferative disorders can sometimes by tricky. When the morphology and flow cytometric studies are classic, the case should not present a diagnostic challenge. However, when the lesion does not read the book, one must take into consideration the morphology/cytology, flow cytometry, and clinical history. Integrating all three of these will often lead to the correct diagnosis; however, there will be occasional cases where the best that a pathologist can say is "B-cell lymphoproliferative disorder". In those instances, one should not overcall something, but rather should state what the problems are, and what are most likely to be the diagnostic possibilities.
Ben-Ezra
Jonathan
J
Department of Pathology, Medical College of Virginia, Hospitals of Virginia Commonwealth University, POB 980250, Richmond, VA 23298, USA. jbenezra@vcu.edu
D001402:B-Lymphocytes / Q000737:chemistry / Q000473:pathology*; D015415:Biomarkers; D014408:Biomarkers, Tumor; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000473:pathology*
D015415:Biomarkers; D014408:Biomarkers, Tumor