title: Intensity based affine registration including feature similarity for spatial normalization.
abstract: This paper presents a new spatial normalization with affine transformation. The quantitative comparison of brain architecture across different subjects requires a common coordinate system. For the analysis of a specific brain area, it is required to normalize and compare a region of interest and global brain. Intensity based registration method matches the global brain well. But a region of interest may not be locally normalized compared to feature based method. The method of this paper uses feature similarities of local region as well as intensity similarities. The lateral ventricle and the central gray nuclei of brain including the corpus callosum, which is used for features in Schizophrenia detection, is appropriately normalized. In the results section, our method reduces the difference of feature area such as corpus callosum (7.7%, 2.4%) and lateral ventricle (8.2%, 13.5%) compared with mutual information and Talairach methods.
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Sungdong P.O. Box 55, Seoul 133-605, South Korea.
authors.forename: June-Sic
authors.initials: JS
authors.lastname: Kim
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Yong-Hee
authors.initials: YH
authors.lastname: Lee
authors.forename: Jae-Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: In-Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology; D012984:Software; D013687:Telencephalon / Q000473:pathology; D013698:Templates, Genetic