title: Concomitant risk factors in reports of torsades de pointes associated with macrolide use: review of the United States Food and Drug Administration Adverse Event Reporting System.
abstract: In this case series, we examined concomitant risk factors mentioned in reports of torsades de pointes, a rare ventricular arrhythmia, that occurred in association with administration of macrolide antimicrobials (e.g., azithromycin, clarithromycin, dirithromycin, and erythromycin). Increasing age, female sex, and concomitant diseases and drug administration believed to increase risks for torsades de pointes were commonly reported.
authors.affiliation: Center for Drug Evaluation and Research, United States Food and Drug Administration, Rockville, MD 20850, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Shaffer
authors.forename: Sarah
authors.initials: S
authors.lastname: Singer
authors.forename: Joyce
authors.initials: J
authors.lastname: Korvick
authors.forename: Peter
authors.initials: P
authors.lastname: Honig
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015897:Comorbidity; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006801:Humans; D018942:Macrolides; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides