title: [Plasma Lp (a) levels and correlation of Lp (a) with fibrinolysis activation in chronic renal failure].
abstract: Plasma Lp (a) concentration and activation of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1) were determined in 50 patients with chronic renal failure (CRF) and in 50 healthy subjects. The results demonstrated that plasma concentration of Lp(a) was significantly higher and plasma t-PA activation was significantly lower in CRF patients than in healthy subjects. With multivariate analyses, plasma Lp(a) concentration was positively correlated with the total amount of 24 h uric protein, plasma BUN and uric protein concentration. Moreover, a negative significant correlation between plasma Lp(a) levels and t-PA activation was observed. Plasma Lp(a) levels did not show a correlation to PAI-1 activation. It is indicated that renal function may contribute to moderate plasma Lp(a) concentration and elevated Lp(a) levels may be related with fibrinolytic impairment.
authors.affiliation: Department of Kidney Internal Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Xiong
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Lou
authors.forename: Q
authors.initials: Q
authors.lastname: Hang
mesh_terms: D000328:Adult; D001054:Apolipoproteins A / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D001054:Apolipoproteins A; D017270:Lipoprotein(a); D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator