title: Successful treatment of anogenital Bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by DNA image cytometry.
abstract: Imiquimod (Aldara, 3M) is an immune response modifier used for the treatment of anogenital warts. We report a 55-year-old non-immunocompromised woman with extensive, human papillomavirus (HPV) 16-positive anogenital Bowen's disease. After 5 months of local treatment with imiquimod, the lesions completely regressed clinically and histologically, and HPV 16 DNA was no longer detectable. Moreover, DNA image cytometry revealed DNA aneuploidy (an indicator of prospective malignancy) in pretreatment samples but not in post-treatment samples. Therefore, imiquimod might be a treatment option for Bowen's disease, particularly in patients where other treatment modalities such as surgery are contraindicated.
authors.affiliation: Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str. 5, Germany. rgutzmer@gmx.de
authors.forename: R
authors.initials: R
authors.lastname: Gutzmer
authors.forename: M
authors.initials: M
authors.lastname: Kaspari
authors.forename: M
authors.initials: M
authors.lastname: Vogelbruch
authors.forename: P
authors.initials: P
authors.lastname: Kiehl
authors.forename: A
authors.initials: A
authors.lastname: Kapp
authors.forename: T
authors.initials: T
authors.lastname: Werfel
authors.forename: J-P
authors.initials: JP
authors.lastname: Brodersen
mesh_terms: D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy / Q000473:pathology; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D019044:Image Cytometry / Q000379:methods; D000077271:Imiquimod; D007369:Interferon Inducers / Q000627:therapeutic use*; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D004279:DNA, Viral; D007369:Interferon Inducers; D000077271:Imiquimod