title: A genome scan for Loci associated with aerobic running capacity in rats.
abstract: Aerobic capacity is a complex trait that defines the efficiency to use atmospheric oxygen as an electron acceptor in energy transfer. Copenhagen (COP) and DA inbred rat strains show a wide difference in a test for aerobic treadmill running and serve as contrasting genetic models for aerobic capacity. A genome scan was carried out on an F(2)(COP x DA) segregating population (n=224) to detect quantitative trait loci (QTLs) associated with aerobic running capacity. Linkage analysis revealed a significant QTL on chromosome 16 (lod score, 4.0). A suggestive linkage was found near the p-terminus of chromosome 3 (lod score, 2.2) with evidence of an interaction with another QTL on chromosome 16 (lod score, 2.9). All three QTLs showed a dominant mode of inheritance in which the presence of at least one DA allele was associated with a greater distance run. These results represent the first aerobic capacity QTLs identified in genetic models.
authors.affiliation: Functional Genomics Laboratory, Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio, 43614-5804, USA.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Ways
authors.forename: George T
authors.initials: GT
authors.lastname: Cicila
authors.forename: Michael R
authors.initials: MR
authors.lastname: Garrett
authors.forename: Lauren Gerard
authors.initials: LG
authors.lastname: Koch
mesh_terms: D000818:Animals; D001835:Body Weight; D006321:Heart / Q000033:anatomy & histology; D008297:Male; D018895:Microsatellite Repeats; D009929:Organ Size; D010101:Oxygen Consumption; D010641:Phenotype; D010805:Physical Conditioning, Animal; D010807:Physical Endurance / Q000235:genetics*; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D051381:Rats; D012420:Running