Depression and endogenous melatonin in postmenopausal women.
BACKGROUND
Previous reports on melatonin secretion in depression are numerous but conflicting. There are very few studies relating the duration of the nocturnal melatonin peak to depression, and the results of those studies have been equivocal.


METHODS
We studied mood disorders and urinary melatonin excretion in 382 postmenopausal women. Psychiatric diagnoses and global assessment of functioning (GAF) scores were determined based on a Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Urinary 6-sulfatoxymelatonin (6-SMT) samples were collected for two 24-h periods at home.


RESULTS
A positive family history of depression was significantly related to a longer duration of 6-SMT excretion. There were marginally significant associations between current major depression and delayed offset of 6-SMT excretion and between later acrophase and lifetime major depression, even with control for age, ethnicity, season, and several medications.


CONCLUSIONS
The subjects were studied in their home environments, where light effects were not controlled. Data were restricted to postmenopausal women, including a limited number of subjects with current major depression.


CONCLUSIONS
These results suggest that there might be a familial vulnerability in the endogenous melatonin signal in subjects prone to depression, and an abnormality in the duration of the melatonin signal in those with current major depression.
Tuunainen
Arja
A
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, Dept. 0667, La Jolla, CA 92093-0667, USA.
Kripke
Daniel F
DF
Elliott
Jeffrey A
JA
Assmus
Joseph D
JD
Rex
Katharine M
KM
Klauber
Melville R
MR
Langer
Robert D
RD
D000368:Aged; D000369:Aged, 80 and over; D003866:Depressive Disorder / Q000503:physiopathology* / Q000652:urine; D003865:Major Depressive Disorder / Q000503:physiopathology / Q000652:urine; D005260:Female; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine*; D008875:Middle Aged; D019964:Mood Disorders / Q000503:physiopathology / Q000652:urine
C054513:6-sulfatoxymelatonin; D008550:Melatonin