Human type 1 estrogen sulfotransferase: catecholestrogen metabolism and potential involvement in cancer promotion.
Using purified human type 1 estrogen sulfotransferase (hEST1), we show that the best substrate for this enzyme is 2-hydroxy-catecholestrogen. The enzyme also catalyzes the transformation of 4-hydroxy-estrogens and 16-hydroxy-estrogens, but with a lower affinity. We also present evidence to indicate that estrogen sulfotransferase may play a role in processes other than the detoxification and elimination of steroids. Indeed, hEST1 may also be involved in the production of stable precursors for local steroid biosynthesis or in the activation of promutagenic estrogen metabolites into carcinogens.
Faucher
Frederic
F
Oncology and Molecular Endocrinology Research Center, Laval University Medical Center (CHUL) and Laval University, Quebec G1V 4G2, Canada.
Lacoste
Lucille
L
Luu-The
Van
V
D002273:Carcinogens / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003276:Contraceptives, Oral / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism; D002393:Estrogens, Catechol / Q000378:metabolism* / Q000502:physiology; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology; D005656:Fungal Proteins / Q000378:metabolism*; D006801:Humans; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D020011:Protective Agents / Q000494:pharmacology; D029701:Saccharomyces cerevisiae Proteins; D019098:Telomerase / Q000378:metabolism*
D002273:Carcinogens; D003276:Contraceptives, Oral; D004967:Estrogens; D002393:Estrogens, Catechol; D004968:Estrogens, Non-Steroidal; D005656:Fungal Proteins; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D020011:Protective Agents; D029701:Saccharomyces cerevisiae Proteins; C099024:EST1 protein, S cerevisiae; D019098:Telomerase