title: Alterations of motor nerve functions in animals exposed to motorcycle exhaust.
abstract: The effect of motorcycle exhaust (ME) on the motor nerve was studied using animals exposed to the exhaust by inhalation, intratracheal, or intraperitoneal administration of ME particulate (MEP). A 4-wk ME inhalation and intratracheal instillation of MEP for 1 d in rats or intraperitoneal administration of MEP (0.5 g/kg/d for 1 d and 0.1 g/kg/d for 2 d) in mice significantly decreased both rota-rod performance and motor nerve conduction velocity. The effect of some polycyclic aromatic hydrocarbons on the motor nerve was also investigated. Treatment with benzo[a]pyrene (0.05 and 0.1 g/kg/d for 3 d), but not pyrene (0.1 g/kg/d for 3 d), resulted in significant decrease of motor nerve conduction velocity in mice. Moreover, the Na(+),K(+)-ATPase activities of sciatic nerves isolated from ME-, MEP-, or benzo[a]pyrene-exposed animals were decreased. Treatment with pyrene did not markedly affect the Na(+),K(+)-ATPase activity of sciatic nerve. The rats exposed to ME for 4 wk showed increases in blood and sciatic nerve manganese levels. Results indicate that motorcycle exhaust produces adverse effects on the motor nerve, which is associated with a fall in nerve Na(+),K(+)-ATPase activity.
authors.affiliation: Institute of Toxicology, Medical College, National Taiwan University, Taipei, Taiwan. shliu@ha.mc.ntu.edu.tw
authors.forename: Shing-Hwa
authors.initials: SH
authors.lastname: Liu
authors.forename: Jei-Hui
authors.initials: JH
authors.lastname: Wang
authors.forename: Jiunn-Jye
authors.initials: JJ
authors.lastname: Chuu
authors.forename: Shoei-Yn
authors.initials: SY
authors.lastname: Lin-Shiau
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007442:Intubation, Intratracheal; D008297:Male; D008345:Manganese / Q000097:blood / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009048:Motor Skills / Q000187:drug effects; D009049:Motorcycles; D009431:Neural Conduction / Q000187:drug effects*; D011084:Polycyclic Aromatic Hydrocarbons / Q000008:administration & dosage / Q000009:adverse effects*; D011721:Pyrenes / Q000008:administration & dosage / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects* / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D001335:Vehicle Emissions / Q000009:adverse effects*
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; D001335:Vehicle Emissions; D001564:Benzo(a)pyrene; D008345:Manganese; C030984:pyrene; D000254:Sodium-Potassium-Exchanging ATPase