Development of extended release dosage forms using non-uniform drug distribution techniques.
Development of an extended release oral dosage form for nifedipine using the non-uniform drug distribution matrix method was conducted. The process conducted in a fluid bed processing unit was optimized by controlling the concentration gradient of nifedipine in the coating solution and the spray rate applied to the non-pareil beads. The concentration of nifedipine in the coating was controlled by instantaneous dilutions of coating solution with polymer dispersion transported from another reservoir into the coating solution at a controlled rate. The USP dissolution method equipped with paddles at 100 rpm in 0.1 N hydrochloric acid solution maintained at 37 degrees C was used for the evaluation of release rate characteristics. Results indicated that (1) an increase in the ethyl cellulose content in the coated beads decreased the nifedipine release rate, (2) incorporation of water-soluble sucrose into the formulation increased the release rate of nifedipine, and (3) adjustment of the spray coating solution and the transport rate of polymer dispersion could achieve a dosage form with a zero-order release rate. Since zero-order release rate and constant plasma concentration were achieved in this study using the non-uniform drug distribution technique, further studies to determine in vivo/in vitro correlation with various non-uniform drug distribution dosage forms will be conducted.
Huang
Kuo-Kuang
KK
Tajen Institute of Technology, Pingtung, Taiwan. leon@ccsun.tajen.edu.tw
Wang
Da-Peng
DP
Meng
Chung-Ling
CL
D000284:Administration, Oral; D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D007700:Kinetics; D009543:Nifedipine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011817:Rabbits; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; C013517:ethyl cellulose; D002482:Cellulose; D009543:Nifedipine