[Transforming growth factor beta 1 and interleukin 6 mRNA expression in wound tissues of patients with diabetic ulcers].
OBJECTIVE
To study the relationship between the changes of mRNA expression in wound tissues of diabetic ulcers and tissue repair.


METHODS
The mRNA expression of TGF-beta 1 and IL-6 in eight bioptic samples of diabetic ulcers were detected by RT-PCR and pathologic methods, and the surrounding normal skins from the same patients were measured as control group.


RESULTS
The mRNA expression levels of TGF-beta 1 were markedly decreased in the diabetic ulcers compared with control group, while the mRNA expression levels of IL-6 were increased at the same reaction conditions.


CONCLUSIONS
The different changes of mRNA expression level of TGF-beta 1 and IL-6 in wound tissue result in low production and decreased activity of TGF-beta 1 and IL-6, which lower the reparative ability of wound tissue.
Fu
X B
XB
304th Hospital of PLA, Beijing, P. R. China 100037.
Yang
Y H
YH
Sun
T Z
TZ
D000368:Aged; D017719:Diabetic Foot / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D014945:Wound Healing
D015850:Interleukin-6; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta