Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues.
Expression levels of cytochrome CYP26B1, which is involved in the specific all-trans-RA inactivation, were evaluated in human cephalic tissues at gestational days 57-110 and exhibited values approximately 10-fold higher than later gestational days 112-224 and adult tissues. CYP26B1 mRNA levels in the adult cerebellum were approximately 2-fold higher than in the adult whole brain tissue. Considered together, these data suggest a unique role for CYP26B1 during human brain development.
Trofimova-Griffin
Marina E
ME
Department of Pharmacology, School of Medicine, Box 357280, University of Washington, Seattle, WA 98195-7280, USA. griffin3@gte.net
Juchau
Mont R
MR
D001921:Brain / Q000166:cytology / Q000196:embryology / Q000201:enzymology*; D002454:Cell Differentiation / Q000502:physiology*; D002531:Cerebellum / Q000166:cytology / Q000196:embryology / Q000201:enzymology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology / Q000201:enzymology*; D005333:Fetus / Q000166:cytology / Q000196:embryology / Q000201:enzymology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism*; D000072516:Retinoic Acid 4-Hydroxylase; D014212:Tretinoin / Q000378:metabolism*
D012333:RNA, Messenger; D014212:Tretinoin; D003577:Cytochrome P-450 Enzyme System; D000072516:Retinoic Acid 4-Hydroxylase