title: Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder.
abstract: The purpose of this study was to evaluate the relationship between attention deficit hyperactivity disorder (ADHD) and polymorphism of the two regions of the 5-HTT gene [variable number of tandem repeats (VNTR) and 5-HTTLRR] in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 71 patients with ADHD and 128 healthy controls. The 5-HTTLPR S/S genotype was significantly lower in the patients than in the controls (p = 0.018). Homozygous and heterozygous L variant predominated in the ADHD group. But the VNTR STin2.12/12 genotype was significantly less found in the patients than in the controls (p = 0.001). There was no significant difference between the frequency of the short (S), long, 10, and 12 alleles of both groups. The lack of an S/S variant of 5-HTTLPR polymorphism of the STin2.12/12 variant of VNTR polymorphism appears to be associated with an increased risk of ADHD.
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine, Gaziantep University, Kolejtepe, Gaziantep, Turkey. zoroglus@hotmail.com
authors.forename: Salih Süleyman
authors.initials: SS
authors.lastname: Zoroğlu
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Erdal
authors.forename: Belgin
authors.initials: B
authors.lastname: Alaşehirli
authors.forename: Nurten
authors.initials: N
authors.lastname: Erdal
authors.forename: Ercan
authors.initials: E
authors.lastname: Sivasli
authors.forename: Hamdi
authors.initials: H
authors.lastname: Tutkun
authors.forename: Haluk A
authors.initials: HA
authors.lastname: Savaş
authors.forename: Hasan
authors.initials: H
authors.lastname: Herken
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012701:Serotonin / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins; D020080:Tandem Repeat Sequences; D014421:Turkey
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin