[Effect of RNA against hepatic fibrosis in rabbits infected with Schistosoma japonicum].
OBJECTIVE
To study the effect of ribonucleic acid (RNA) against schistosomal hepatic fibrosis in rabbits.


METHODS
54 rabbits were randomly and equally divided into normal group, infected group, and RNA group. On the 40, 70, 100th day after RNA i.m. injection, 6 rabbits from each of the above 3 groups were killed and their plasma and liver were examined by way of biochemistry and pathology.


RESULTS
Compared with the infected group the collagen fiber of liver in RNA group was less produced, the hepatic cellular nucleolus was enlarged, the number of rough endoplasmic reticulum (RER) and the granules on the RER were increased, the collagen fiber around fat-storing cell was decreased, the content of hyaluronic acid in plasma, the hydroxyproline level in liver tissue, the percentage of collagen fiber distribution and the collagen fiber level in liver tissue of RNA group were significantly reduced.


CONCLUSIONS
RNA might play a role in the prevention of schistosomal hepatic fibrosis.
Peng
Y
Y
First Affiliated Hospital, Hubei Medical University, Wuhan 430060.
Huang
Q
Q
Yan
S
S
Deng
B
B
Hu
J
J
D000818:Animals; D005260:Female; D006820:Hyaluronic Acid / Q000097:blood; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism / Q000469:parasitology* / Q000517:prevention & control*; D008297:Male; D012313:RNA / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation; D012554:Schistosomiasis japonica
D012313:RNA; D006820:Hyaluronic Acid; D006909:Hydroxyproline