Effects of carbendazim on rat thyroid, parathyroid, pituitary and adrenal glands and their hormones.
The purpose of this study is to determine the effects of low and high dose of carbendazim on the level of certain hormones and endocrine glands (thyroid, parathyroid, adrenal and pituitary glands) of male rats. Carbendazim is a systemic fungicide with activity against a number of plant pathogens. In this study, daily doses of 0, 150, 300 and 600 mg/kg per day carbendazim were applied to male rats by gavage for 15 weeks. At the end of the experiment, T3, T4, TSH, ACTH and GH levels in rat serum were analysed. Thyroid, parathyroid, adrenal and pituitary glands of rats were taken. A significant increase was observed in serum T3 levels of the rats, which were exposed to 300 mg/kg per day carbendazim doses, compared to the serum T3 levels of the control group. There were no differences between the control and carbendazim-treated group of rats regarding serum TSH, T4, ACTH and growth hormone levels. This showed us that carbendazim caused histopathological damages in thyroid, parathyroid and adrenal glands of rats. No changes were observed in pituitary glands of treated rats. These results suggest that a high quantity of subchronic carbendazim exposure affects thyroid, parathyroid and adrenal glands.
Barlas
N
N
Department of Biology, Science Faculty, Hacettepe University, Beytepe, Ankara, Turkey. barlas@hacettepe.edu.tr
Selmanoglu
G
G
Koçkaya
A
A
Songür
S
S
D000311:Adrenal Glands / Q000187:drug effects* / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002219:Carbamates; D013006:Growth Hormone / Q000032:analysis; D006728:Hormones / Q000032:analysis*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010280:Parathyroid Glands / Q000187:drug effects* / Q000473:pathology; D010902:Pituitary Gland / Q000187:drug effects*; D011863:Radioimmunoassay; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D013972:Thyrotropin / Q000032:analysis; D013974:Thyroxine / Q000032:analysis; D014284:Triiodothyronine / Q000032:analysis
D000393:Air Pollutants; D001562:Benzimidazoles; D002219:Carbamates; D006728:Hormones; D014284:Triiodothyronine; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D013006:Growth Hormone; C006698:carbendazim; D013974:Thyroxine