A novel method for the analysis of the androgen receptor.
The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computer-assisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.
Gaston
Kris E
KE
Department of Surgery, Division of Urology, University of North Carolina, CB# 7235, Chapel Hill, NC 27599-7235, USA.
Ford III
O Harris
OH
Singh
Swaroop
S
Gregory
Christopher W
CW
Weyel
Donald E
DE
Smith
Gary J
GJ
Mohler
James L
JL
D000818:Animals; D003116:Color; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D011471:Prostatic Neoplasms / Q000737:chemistry; D011944:Receptors, Androgen / Q000032:analysis*; D014741:Video Recording
D011944:Receptors, Androgen