title: Histological and virological features and follow-up of hepatitis C virus carriers with normal aminotransferase levels: the Italian prospective study of the asymptomatic C carriers (ISACC).
abstract: OBJECTIVE
  To evaluate demographic characteristics, liver histology and virological features of hepatitis C virus (HCV) carriers with normal alanine transaminase (ALT) levels.
  
  
  METHODS
  A nationwide prospective study was started in 1997. Four Italian centres have participated in this study.
  
  
  RESULTS
  Eight hundred and eighty subjects entered the study. One hundred and eighty-nine (21.5%) were excluded during the follow-up because of ALT increase. Among the 691 patients with persistent ALT normality, 72% were females. An overall prevalence of genotype 2 was found (52%). Normal liver was found in 17% of the patients; 34% had minimal chronic hepatitis, 44% mild hepatitis, 4% moderate to severe hepatitis, and 1% had cirrhosis. Clinical and virological features did not differ between subjects with ALT flares and those with persistently normal ALT. Baseline ALT levels have no effects on liver histology and clinical outcome.
  
  
  CONCLUSIONS
  Many HCV carriers have significant chronic liver damage, although in the majority of them liver lesions are minimal or mild. Up to 60% of HCV carriers in Italy harbour non-1 HCV types. Current definition of HCV carriers with persistently normal ALT levels, based upon three normal ALT values over a 6-month period, is not adequate to discriminate between carriers with persistent ALT normality and those with transient biochemical remission. Longer follow-ups are needed.
authors.affiliation: Department of Gastroenterology and Internal Medicine, Genzano Hospital, Via Cimone 171, 00141 Rome, Italy. puoti@epatologia.org
authors.forename: Claudio
authors.initials: C
authors.lastname: Puoti
authors.forename: Roberto
authors.initials: R
authors.lastname: Castellacci
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Montagnese
authors.forename: Serena
authors.initials: S
authors.lastname: Zaltron
authors.forename: Gianfranca
authors.initials: G
authors.lastname: Stornaiuolo
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bergami
authors.forename: Lia
authors.initials: L
authors.lastname: Bellis
authors.forename: Davide F
authors.initials: DF
authors.lastname: Precone
authors.forename: Paolo
authors.initials: P
authors.lastname: Corvisieri
authors.forename: Massimo
authors.initials: M
authors.lastname: Puoti
authors.forename: Eliseo
authors.initials: E
authors.lastname: Minola
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Gaeta
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D001706:Biopsy; D002353:Carrier State; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000410:Alanine Transaminase