title: Determination of the target ventricular rate in patients with atrial fibrillation by evaluation of ventriculoarterial coupling.
abstract: In a pilot study, we determined the target ventricular rate of patients with atrial fibrillation by evaluating their ventriculoarterial coupling. Eleven patients with atrial fibrillation were studied. We recorded M-mode echocardiograms and radial artery blood pressure simultaneously. The left ventricular end-systolic pressure-volume ratio (Emax) and effective arterial elastance (Ea) were calculated for each beat, and the relationship of the preceding R-R interval (pRR) to Emax and Ea was evaluated. There was a significant positive correlation between pRR and Emax, and a significant negative correlation between pRR and Ea in all patients. The pRR that produced maximal stroke work was determined at the point of Emax=Ea, and the pRR that achieved maximal mechanical efficiency was determined at the point of 2Ea=Emax. By evaluating ventriculoarterial coupling in these patients who had atrial fibrillation, we were able to determine that the range between the 2 pRR intervals was the range of the optimal ventricular rate. A narrower range of the 2 pRR intervals was observed in patients with dilated cardiomyopathy than in the patients with no underlying cardiac disease. We conclude that it may be possible to determine the optimal ventricular rate in patients with atrial fibrillation by evaluating ventriculoarterial coupling.
authors.affiliation: Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki City, Kanagawa Prefecture, Japan.
authors.forename: Sachihiko
authors.initials: S
authors.lastname: Nobuoka
authors.forename: Seiji
authors.initials: S
authors.lastname: Hatano
authors.forename: Junzo
authors.initials: J
authors.lastname: Nagashima
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshida
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Adachi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Imai
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shibamoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Miyake
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology*; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017534:Radial Artery; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*