title: Linkage analysis of Alzheimer disease with psychosis.
abstract: Although a portion of risk for late-onset AD (LOAD) is attributable to APOE, the search for other loci is ongoing. The authors hypothesize that psychotic symptoms with LOAD (LOAD+P) identify a potentially more etiologically homogeneous form of AD. Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Bacanu
authors.forename: B
authors.initials: B
authors.lastname: Devlin
authors.forename: K V
authors.initials: KV
authors.lastname: Chowdari
authors.forename: S T
authors.initials: ST
authors.lastname: DeKosky
authors.forename: V L
authors.initials: VL
authors.lastname: Nimgaonkar
authors.forename: R A
authors.initials: RA
authors.lastname: Sweet
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005192:Family Health; D006579:Heterozygote; D006801:Humans; D008126:Lod Score; D011618:Psychotic Disorders / Q000150:complications* / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E