The secrets of selective estrogen receptor modulation: cell-specific coregulation.
A specific increase in the level of a single coactivator appears to enhance estrogen action with tamoxifen at some gene targets in uterine cells but not breast cells.
Jordan
V Craig
VC
Robert H. Lurie Comprehensive Cancer Center, The Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. vcjordan@northwestern.edu
D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D051548:Histone Acetyltransferases; D006801:Humans; D008954:Models, Biological; D056920:Nuclear Receptor Coactivator 1; D011960:Receptors, Estrogen / Q000378:metabolism*; D020845:Selective Estrogen Receptor Modulators / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction; D013629:Tamoxifen / Q000494:pharmacology* / Q000627:therapeutic use; D014157:Transcription Factors / Q000502:physiology*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; D014157:Transcription Factors; D013629:Tamoxifen; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; D056920:Nuclear Receptor Coactivator 1