ML -- a conserved domain involved in innate immunity and lipid metabolism.
ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.
Inohara
Naohiro
N
Department of Pathology and Comprehensive Cancer, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ino@umich.edu
Nuñez
Gabriel
G
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D050356:Lipid Metabolism; D008070:Lipopolysaccharides / Q000276:immunology / Q000378:metabolism; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology
D000954:Antigens, Surface; C115213:LY86 protein, human; D008070:Lipopolysaccharides