Microcystic variant of localized malignant mesothelioma accompanying an adenomatoid tumor-like lesion.
The case of a 70-year-old man with a hitherto undescribed pleural mesothelioma is reported. The tumor was localized in the left lung apex and had invaded the parietal pleura. Histologically, the tumor was characterized by a proliferation of epithelioid cells and the formation of microcysts. The tumor cells were positive for calretinin and vimentin, and possessed abundant microvilli, indicating a mesothelial cell origin for the tumor. A high Ki-67 index and mitotic index, and the recurrence of the tumor after surgery, indicated malignancy. Based on the evidence, we propose that the tumor is a microcystic variant of a localized malignant mesothelioma.
Umezu
Hajime
H
Department of Surgical Pathology, Niigata University Hospital, Asahimachi-dori, Japan. umezu@med.niigata-u.ac.jp
Kuwata
Kazuhisa
K
Ebe
Yusuke
Y
Yamamoto
Takashi
T
Naito
Makoto
M
Yamato
Yasushi
Y
Ishiyama
Takaaki
T
Tsuchida
Masanori
M
Okuizumi
Mina
M
Ishikawa
Hiroshi
H
Koizumi
Naoya
N
D000230:Adenocarcinoma / Q000473:pathology; D018254:Adenomatoid Tumor / Q000473:pathology*; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018261:Mesothelioma, Cystic / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary; D010997:Pleural Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure