Generation of dendritic cell-based vaccines for cancer therapy.
Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we discuss various conditions, which are important during generation and administration of dendritic cells to elicit a tumouricidal T cell-based immune response.
Reinhard
G
G
Klinik und Poliklinik für Dermatologie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Germany.
Märten
A
A
Kiske
S M
SM
Feil
F
F
Bieber
T
T
Schmidt-Wolf
I G H
IG
D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects / Q000637:transplantation; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000235:genetics / Q000494:pharmacology; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D005334:Fever / Q000209:etiology; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007114:Immunization; D016233:Immunotherapy, Active / Q000009:adverse effects; D007937:Leukapheresis; D008206:Lymphatic Diseases / Q000209:etiology; D008213:Lymphocyte Activation; D009000:Monocytes / Q000166:cytology / Q000187:drug effects; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D010446:Peptide Fragments / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014162:Transfection
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D016207:Cytokines; D010446:Peptide Fragments