Worsening of multifocal motor neuropathy during pregnancy.
Three women with multifocal motor neuropathy (MMN) were treated during pregnancy. Compared with their pregestation strength, the women became weaker in previously involved muscles and showed new weakness in previously unaffected muscles. All were treated with IV immunoglobulin during pregnancy and improved in strength. After pregnancy, strength in all patients returned to the prepregnancy state. The authors conclude that pregnancy may worsen MMN.
Chaudhry
Vinay
V
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. vchaudh@jhmi.edu
Escolar
Diana M
DM
Cornblath
David R
DR
D000328:Adult; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous; D008475:Median Nerve / Q000502:physiology; D016472:Motor Neuron Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D018908:Muscle Weakness / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D009431:Neural Conduction; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000628:therapy*
D016756:Immunoglobulins, Intravenous