Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model.
We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model.
Brown
N J
NJ
Microcirculation Research Unit, University of Sheffield Medical School, Sheffield S10 2RX, UK.
Staton
C A
CA
Rodgers
G R
GR
Corke
K P
KP
Underwood
J C E
JC
Lewis
C E
CE
D000230:Adenocarcinoma / Q000098:blood supply / Q000209:etiology / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D005338:Fibrin Fibrinogen Degradation Products / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000517:prevention & control*
D005338:Fibrin Fibrinogen Degradation Products; C018543:fibrinogen fragment E