Back to the future: antibody-based strategies for the treatment of infectious diseases.
Before antibiotics, sera from immune animals and humans were used to treat a variety of infectious diseases, often with successful results. After the discovery of antimicrobial agents, serum therapy for bacterial infections was rapidly forsaken. In the last two decades, problems with treatment of newly emerged, re-emerged, or persistent infectious diseases necessitated researchers to develop new and/or improved antibody-based therapeutic approaches. This article reviews some information on the use of antibodies for the treatment of infectious diseases, with special reference to the most seminal discoveries and current advances as well as available treatment approaches in this field.
Oral
H Barbaros
HB
Department of Microbiology and Infectious Diseases, School of Medicine, Uludag University, Bursa, Turkey. oralb@uludag.edu.tr
Ozakin
Cüneyt
C
Akdiş
Cezmi A
CA
D000818:Animals; D000907:Antibodies, Bacterial / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007239:Infections / Q000628:therapy*; D014777:Virus Diseases / Q000628:therapy
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral