title: Clinical manifestations of head and neck irradiation.
abstract: Treatment of squamous cell carcinoma of the oral cavity, salivary gland tumors, and Hodgkin's disease may include radiation therapy to the head and neck region. This therapy has treatment-related sequelae to the oral cavity and can contribute to increased rates of dental caries in these patients. To prevent radiation-induced caries, patients are instructed to use a high-potency fluoride application in addition to their standard dentifrice during radiation therapy and the postradiation phases of their treatment. Traditionally, patients are prescribed a 5,000-ppm fluoride (F) gel that is applied using mouthguards. However, due to oral postoperative conditions, many patients are not complaint with this treatment. In many cases, the availability of a fluoride product that is easier to use could result in successful patient compliance.
authors.affiliation: Dental Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: I M
authors.initials: IM
authors.lastname: Zlotolow
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D002327:Cariostatic Agents / Q000008:administration & dosage; D003731:Dental Caries / Q000209:etiology* / Q000517:prevention & control; D003802:Dentifrices / Q000627:therapeutic use; D005459:Fluorides / Q000008:administration & dosage; D005460:Fluorides, Topical / Q000008:administration & dosage; D005782:Gels; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D008336:Mandibular Diseases / Q000209:etiology; D009062:Mouth Neoplasms / Q000532:radiotherapy; D009064:Mouth Protectors; D009910:Oral Hygiene; D010025:Osteoradionecrosis / Q000209:etiology; D010349:Patient Compliance; D011832:Radiation Injuries / Q000209:etiology* / Q000517:prevention & control; D011862:Radiography, Panoramic; D012468:Salivary Gland Neoplasms / Q000532:radiotherapy; D014081:Tooth Extraction; D014099:Toothbrushing; D014987:Xerostomia / Q000209:etiology / Q000517:prevention & control
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D005460:Fluorides, Topical; D005782:Gels; D005459:Fluorides