Effect of hyperthermia by magnetite cement on tumor-induced bone destruction.
Our study focuses on the antineoplasmic action of hyperthermia. In this study, use of a heat-generating cement was exploited for the management of pathological and impending fractures in malignancies. The cement contains magnetic powder in ceramic particles and generates well-regulated heat when a magnetic field is applied externally. Eighteen rabbits were inoculated with blocks of VX2 tumor into one of their tibia. One week after the procedure, 9 rabbits were exposed to a magnetic field (HT group) while the remaining 9 rabbits were not (non-HT group). In rabbits killed between 20 and 42 days after the VX2 inoculation, the circumference of the operated leg was 7.9 +/- 0.3 cm and 10.2 +/- 1.0 cm (mean +/- SE) in HT and non-HT groups, respectively ( P < 0.05). Histological findings revealed the regressive change in tumor tissue of the HT group. By radiographs, pathological fractures and cortical bone destruction were seen in 5 and 8 rabbits in the non-HT group, respectively, but in the HT group these effects were absent in all the rabbits except 1 in which a definite diagnosis has not been made. Our findings demonstrate that controlled hyperthermia therapy using a newly developed bone cement suppresses tumor growth and prevents local bone destruction caused by VX2 tumors.
Kusaka
Masaya
M
Department of Orthopaedic Surgery, Kusaka Hospital, 680 Ageki, Hokusei-cho, Inabe-gun, Mie 511-0428, Japan.
Takegami
Kenji
K
Sudo
Akihiro
A
Yamazaki
Takashi
T
Kawamura
Jiro
J
Uchida
Atsumasa
A
D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000628:therapy*; D052203:Ferrosoferric Oxide; D006979:Hyperthermia, Induced / Q000379:methods*; D007501:Iron / Q000627:therapeutic use*; D010087:Oxides / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation
D001843:Bone Cements; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide