title: Children with ADHD and motor dysfunction compared with children with ADHD only.
abstract: The purpose of this study was to identify group differences in children with attention-deficit-hyperactivity disorder and motor dysfunction (ADHD-MD) and ADHD only, and to evaluate the medication responsiveness of ADHD-MD. Sixty-three children (49 males and 14 females; mean age 9 years 10 months, SD 2 years 10 months) underwent a triple blind, placebo-controlled crossover study evaluating two dose levels of methylphenidate (0.3 mg/kg and 0.5 mg/kg [DOSAGE ERROR CORRECTED], twice daily) and placebo. Forty-nine trials were completed. Nineteen were children with ADHD-MD, 44 had ADHD only. Behavior and functioning were assessed at home and at school. Treatment effects were assessed using the Abbreviated Symptom Questionnaire for Parents and Teachers. Children with ADHD-MD were more likely to have severe ADHD-combined type and other neurodevelopmental and behavioral problems. Both groups of children had a linear dose response to medication (placebo, low, high) and there was no evidence of a group by dose interaction or an overall group effect at home or school. The lack of group effect suggests that these children responded to medication like the other subgroups.
authors.affiliation: Department of Pediatrics, University of Minnesota, Minneapolis, USA. rtervo@gillettechildrens.com
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Tervo
authors.forename: Scott
authors.initials: S
authors.lastname: Azuma
authors.forename: Bruce
authors.initials: B
authors.lastname: Fogas
authors.forename: Helen
authors.initials: H
authors.lastname: Fiechtner
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002648:Child; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D019957:Motor Skills Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate