title: Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report.
abstract: Primary bony lymphomas are rare, and nearly all are high-grade B-cell lymphomas. Natural killer (NK)/T-cell lymphomas are highly aggressive lymphomas of NK- or T-cell lineage with predominant extranodal presentation and are divided into nasal and nasal-type (extra-nasal). We report a primary bony peripheral T-cell lymphoma mimicking NK/T-cell lymphoma, nasal type. A 22-year-old Taiwanese male presented with a frontal skull bone mass noted for 3 weeks, and received craniectomy with tumor removal. His tumor showed extensive coagulative necrosis with angioinvasion by large lymphoma cells expressing CD2, CD8, CD16, CD43, CD45, CD45RO, CD56, T-cell intracellular antigen-1, and granzyme B, but not CD3, CD4, CD20, CD57, CD68, and betaF1. In situ hybridization for Epstein-Barr virus-encoded mRNA was negative. Polymerase chain reaction study of formalin-fixed tissue showed clonal rearrangement of the T-cell receptor-gamma chain gene. The diagnosis was peripheral T-cell lymphoma, unspecified subtype. The initial stage was I(EA). His lymphoma was refractory to chemotherapy, and bony metastases developed in the right iliac bone 2 months later. He died of disease after 6 months without autopsy. We emphasize the importance of detailed immunohistochemical and gene rearrangement studies for the classification of malignant lymphomas via a very rare primary bony lymphoma of peripheral T-cell subtype.
authors.affiliation: Department of Pathology, Chi-Mei Medical Center, Yung-kang City, Tainan, Taiwan. ssc6061@ms16.hinet.net
authors.forename: Shih-Sung
authors.initials: SS
authors.lastname: Chuang
authors.forename: Chin-Nan
authors.initials: CN
authors.lastname: Lin
authors.forename: Chin-Yang
authors.initials: CY
authors.lastname: Li
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000235:genetics; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005624:Frontal Bone / Q000473:pathology; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D009669:Nose Neoplasms / Q000473:pathology*; D016133:Polymerase Chain Reaction
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm