title: The mechanism of fluoride protection.
abstract: Since the 1940s, researchers have understood the positive effect of fluoride on anticaries activity. Several studies, beginning with the Cheektowaga study, showed that an increased number of concentrated fluoride applications also have a beneficial effect on anticaries activity. In fact, the continuous presence of high-fluoride concentrations has a more significant protective effect than enamel fluoride. A high-potency dentifrice is the ideal form with which to produce protective effects. This article describes how high-fluoride concentrations affect dental caries.
authors.forename: J R
authors.initials: JR
authors.lastname: Mellberg
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000008:administration & dosage / Q000494:pharmacology; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology*; D003731:Dental Caries / Q000517:prevention & control*; D003733:Dental Caries Susceptibility / Q000187:drug effects; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D003773:Dental Plaque / Q000378:metabolism; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology*; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000494:pharmacology; D005782:Gels; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism; D009067:Mouthwashes; D017001:Tooth Demineralization / Q000378:metabolism; D014089:Tooth Remineralization; D014099:Toothbrushing
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D005782:Gels; D009067:Mouthwashes; D000149:Acidulated Phosphate Fluoride; D005459:Fluorides