Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats.
In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2'-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.
Kim
Ee-Hwa
EH
Department of Meridianology, College of Oriental Medicine, Semyung University, Chungbuk, South Korea.
Jang
Mi-Hyeon
MH
Shin
Min-Chul
MC
Lim
Baek-Vin
BV
Kim
Hyun-Bae
HB
Kim
Youn-Jung
YJ
Chung
Joo-Ho
JH
Kim
Chang-Ju
CJ
D026881:Acupuncture; D000818:Animals; D000963:Antimetabolites; D001973:Bromodeoxyuridine; D002452:Cell Count; D002455:Cell Division; D018891:Dentate Gyrus / Q000166:cytology* / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology / Q000628:therapy; D009478:Neuropeptide Y / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000963:Antimetabolites; D009478:Neuropeptide Y; D001973:Bromodeoxyuridine