Impact of glycosylation on the effect of cytokines. A special focus on oncology.
The clinical use of cytokines is largely confined to the field of cancer treatment. Industrial procedures for the preparation of cytokines may or may not affect the glycosylation status of several cytokines. The glycosylation of cytokines may be of importance for the accomplishment of their biological functions, including their biological stability, their interaction with specific receptors and their pharmacokinetic behavior. The purpose of this review is thus to describe and discuss the role of cytokine glycosylation, based on experimental data, and with the clinical perspective on oncology. There is no general rule governing the effects induced by the presence of glycosylation on cytokine activity. Among different cytokines concerned by glycosylation status, data concerning G-CSF are sufficient to translate experimental findings into clinical evidence. For this cytokine, glycosylation confers advantages for both stability and biological activity. Although at weight equivalence, the glycosylated form confers greater biological activity than the non-glycosylated form, clinical studies have demonstrated that efficacy remains the same when glycosylated and non-glycosylated G-CSF are prescribed at bioequivalent doses.
Chamorey
Anne-Laure
AL
Centre Antoine-Lacassagne, Oncopharmacology Unit, 33, avenue de Valombrose, 06189 Nice Cedex 2, France.
Magné
Nicolas
N
Pivot
Xavier
X
Milano
Gérard
G
D000818:Animals; D016207:Cytokines / Q000502:physiology* / Q000627:therapeutic use*; D006031:Glycosylation; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D018121:Receptors, Cytokine / Q000502:physiology
D016207:Cytokines; D018121:Receptors, Cytokine