Generalized topological spaces in evolutionary theory and combinatorial chemistry.
The search spaces in combinatorial chemistry as well as the sequence spaces underlying (molecular) evolution are conventionally thought of as graphs. Recombination, however, implies a nongraphical structure of the combinatorial search spaces. These structures, and their implications for search process itself, are heretofore not well understood in general. In this contribution we review a very general formalism from point set topology and discuss its application to combinatorial search spaces, fitness landscapes, evolutionary trajectories, and artificial chemistries.
Stadler
Bärbel M R
BM
Institut für Theoretische Chemie und Molekulare Strukturbiologie Universität, Wien, Vienna, Austria. baer@tbi.univie.ac.at
Stadler
Peter F
PF
D001483:Base Sequence; D005075:Biological Evolution; D020650:Combinatorial Chemistry Techniques; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry
D012313:RNA