title: Intravascular volume monitoring and extravascular lung water in septic patients with pulmonary edema.
abstract: OBJECTIVE
  To evaluate whether different indicators using for guiding volume expansion are valuable tools to assess edematous lung injury in patients with septic shock.
  
  
  METHODS
  Prospective observational clinical study in a university intensive care unit.
  
  
  METHODS
  Sixteen consecutive mechanically ventilated patients developing septic shock with evidence of pulmonary edema on chest radiograph and severe hypoxemia (PaO(2)/FIO(2) <250 mmHg).
  
  
  RESULTS
  A pulmonary artery catheter was used for the measurement of cardiac index (CI), central venous pressure (CVP), and pulmonary artery occlusion pressure (PAOP). A fiberoptic catheter was placed in the descending aorta. Measurements of extravascular lung water index (EVLWI), intrathoracic blood volume index (ITBVI), and total end-diastolic volume index (TEDVI) were obtained using the thermal dye dilution technique. Measurements were taken just after placement of catheters and 24 h later. Fluid balance was also estimated within the first 24 h. TEDVI and ITBVI were significantly correlated with EVLWI, but not CVP and PAOP. Analysis of 24-h changes showed that the changes in TEDVI and in ITBVI reflected the change in EVLWI, whereas PAOP, CVP, and fluid balance did not.
  
  
  CONCLUSIONS
  Volume variables (TEDVI, ITBVI) are more useful indicators than pressure variables (CVP, PAOP) for assessment of EVLWI in septic patients with pulmonary edema.
authors.affiliation: Polyvalent Intensive Care Unit, University Hospital of Besançon, Boulevard Fleming, 25030 Besançon Cedex, France. s.boussat@chu-nancy.fr
authors.forename: Sandrine
authors.initials: S
authors.lastname: Boussat
authors.forename: Thierry
authors.initials: T
authors.lastname: Jacques
authors.forename: Bruno
authors.initials: B
authors.lastname: Levy
authors.forename: Evelyne
authors.initials: E
authors.lastname: Laurent
authors.forename: Antoine
authors.initials: A
authors.lastname: Gache
authors.forename: Gilles
authors.initials: G
authors.lastname: Capellier
authors.forename: Alain
authors.initials: A
authors.lastname: Neidhardt
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001811:Blood Volume Determination; D015633:Extravascular Lung Water; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011654:Pulmonary Edema / Q000150:complications* / Q000503:physiopathology; D012772:Shock, Septic / Q000150:complications*