Assessment of optic disc anatomy and nerve fiber layer thickness in ocular hypertensive subjects with normal short-wavelength automated perimetry.
OBJECTIVE
To compare optic disc topography and nerve fiber layer thickness in ocular hypertensive eyes and normal subjects.


METHODS
Prospective, case-controlled study.


METHODS
One eye in each of 20 normal and 27 ocular hypertensive patients was enrolled.


METHODS
Consecutive normal and ocular hypertensive patients were enrolled. Each patient underwent complete ophthalmic examination, achromatic automated perimetry, short-wavelength automated perimetry, confocal scanning laser ophthalmoscopy, confocal scanning laser polarimetry, and optical coherence tomography. The intraocular pressure was 21 mmHg or less for normal subjects and at least 25 mmHg on two separate occasions in ocular hypertensive eyes. Structural parameters were compared between the two groups. Eyes with evidence of glaucomatous optic neuropathy, achromatic visual field loss, or evidence of focal visual field injury during short-wavelength automated perimetry were excluded.


METHODS
Optic nerve head topography and nerve fiber layer thickness.


RESULTS
The three imaging technologies could not detect differences in optic disc or nerve fiber layer anatomy between the two groups. Ocular hypertensive eyes had a greater corrected pattern standard deviation than normal eyes during short-wavelength automated perimetry (P = 0.04).


CONCLUSIONS
Ocular hypertensive eyes with normal achromatic automated perimetry and short-wavelength automated perimetry could not be distinguished from normal subjects with confocal scanning laser ophthalmoscopy, confocal scanning laser polarimetry, and optical coherence tomography.
Mistlberger
Andrea
A
Department of Ophthalmology, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA.
Liebmann
Jeffrey M
JM
Greenfield
David S
DS
Hoh
Sek-Tien
ST
Ishikawa
Hiroshi
H
Marmor
Michael
M
Ritch
Robert
R
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007368:Interferometry; D007429:Intraocular Pressure; D007834:Lasers; D008027:Light; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis*; D009887:Ophthalmoscopy / Q000379:methods; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields