title: Graded balloon atrial septostomy in severe pulmonary hypertension.
abstract: BACKGROUND
  The prognosis of patients with severe primary pulmonary hypertension is poor. The role of balloon atrial septostomy as a palliative procedure in these patients is not well defined. We retrospectively analyzed our data regarding the safety, clinical outcome and survival benefit of graded balloon atrial septostomy in patients with severe pulmonary hypertension.
  
  
  RESULTS
  Eleven patients (7 males), aged 6 to 30 years (mean age 16.2+/-8.9 years), with severe pulmonary artery hypertension (mean pulmonary artery pressure of 76+/-16.9 mmHg) and refractory congestive heart failure and/or recurrent syncope underwent balloon atrial septostomy. Graded balloon dilatation under echocardiographic guidance and arterial oxygen saturation monitoring was done in all the patients. Procedure-related mortality was 18.2%. Significant acute hemodynamic improvement was seen in the survivors (pre-balloon atrial septostomy cardiac index 1.88+/-0.48 L/min/m2; post-balloon atrial septostomy cardiac index 2.18+/-0.37 L/min/m2, p<0.009). Patients were followed up for a mean period of 20.3 months after the procedure (range: 3 months-5 years). There was functional improvement and increased exercise tolerance in all the patients for a mean follow-up period of 14.6 months (NYHA functional class 3.62+/-0.69 to 2+/-0.50). The estimated probability of survival in this cohort at 1 year was only 48%; but 7 of 8 patients (87%) who survived the procedure were alive at 1 year.
  
  
  CONCLUSIONS
  We conclude that balloon atrial septostomy improves clinical status, hemodynamic variables and possibly also improves survival in selected patients with severe pulmonary artery hypertension. It remains a definite palliative option for refractory primary pulmonary hypertension. However, the procedure-related risks are high in very sick patients and, therefore, balloon atrial septostomy may be advocated early in the course of the disease.
authors.affiliation: Department of Cardiology, Cardio-thoracic Centre, All India Institute of Medical Sciences, New Delhi.
authors.forename: S S
authors.initials: SS
authors.lastname: Kothari
authors.forename: A
authors.initials: A
authors.lastname: Yusuf
authors.forename: R
authors.initials: R
authors.lastname: Juneja
authors.forename: R
authors.initials: R
authors.lastname: Yadav
authors.forename: N
authors.initials: N
authors.lastname: Naik
mesh_terms: D000328:Adult; D002404:Catheterization / Q000379:methods* / Q000401:mortality; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006346:Heart Septum / Q000601:surgery*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D010166:Palliative Care / Q000379:methods; D012189:Retrospective Studies; D013997:Time Factors