Solid-phase preparation of amides using N-acylbenzotriazoles.
Wang resin linked amines were efficiently converted into amides using acylbenzotriazoles. Cleavage of resins gave the desired amides 7Aa-Gf in 30-99% yields with good to excellent purities.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville 32611-7200, USA. katritzky@chem.ufl.edu
Rogovoy
Boris V
BV
Kirichenko
Nataliya
N
Vvedensky
Vladimir
V
D000215:Acylation; D000577:Amides / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D012117:Resins, Synthetic / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
D000577:Amides; D000588:Amines; D012117:Resins, Synthetic; D014230:Triazoles