Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders.
Alterations of G proteins have been implicated in major psychiatric illnesses. A C825T polymorphism of a gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder. We examined whether this polymorphism is associated with functional psychoses in a Japanese sample of 370 schizophrenics, 164 bipolars, 68 depressive patients, and 198 controls. We obtained no evidence for an association of the polymorphism with any diagnostic group.
Kunugi
H
H
Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo, Japan.
Kato
T
T
Fukuda
R
R
Tatsumi
M
M
Sakai
T
T
Nanko
S
S
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*
C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins