Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients.
OBJECTIVE
Elevated basal cortisol levels are a feature of depressive illness and cause deficits in learning and memory. The adrenal steroid dehydroepiandrosterone (DHEA) has antiglucocorticoid properties that may offer protection against the deleterious effects of cortisol. The authors examined the ratio of cortisol to DHEA in drug-free depressed patients and a matched comparison group.


METHODS
Cortisol and DHEA were measured in saliva samples from 39 patients with unipolar depression who had been medication free for at least 6 weeks and 41 healthy comparison subjects.


RESULTS
The molar cortisol-DHEA ratio was significantly higher in the depressed patients than in the healthy comparison subjects. Cortisol-DHEA ratios from saliva samples taken at 8:00 p.m. correlated positively with length of current depressive episode.


CONCLUSIONS
Elevated cortisol-DHEA ratios may be a state marker of depressive illness and may contribute to the associated deficits in learning and memory. Administration of DHEA or other antiglucocorticoid treatments may reduce neurocognitive deficits in major depression.
Young
Allan H
AH
Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK. a.h.young@ncl.ac.uk
Gallagher
Peter
P
Porter
Richard J
RJ
D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D002940:Circadian Rhythm / Q000502:physiology; D003072:Cognition Disorders / Q000188:drug therapy; D003687:Dehydroepiandrosterone / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism
D015415:Biomarkers; D003687:Dehydroepiandrosterone; D006854:Hydrocortisone