title: Handedness of the herpes simplex virus capsid and procapsid.
abstract: The capsid of herpes simplex virus has an icosahedral surface lattice with a nonskew triangulation number, T=16. Nevertheless, the proteins arrayed on this lattice necessarily have an intrinsic handedness. We have determined the handedness of both the herpes simplex virus type 1 capsid and its precursor procapsid by a cryoelectron microscopic tilting method.
authors.affiliation: Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Naiqian
authors.initials: N
authors.lastname: Cheng
authors.forename: Benes L
authors.initials: BL
authors.lastname: Trus
authors.forename: David M
authors.initials: DM
authors.lastname: Belnap
authors.forename: William W
authors.initials: WW
authors.lastname: Newcomb
authors.forename: Jay C
authors.initials: JC
authors.lastname: Brown
authors.forename: Alasdair C
authors.initials: AC
authors.lastname: Steven
mesh_terms: D002213:Capsid / Q000737:chemistry*; D020285:Cryoelectron Microscopy / Q000379:methods; D008958:Models, Molecular; D011498:Protein Precursors / Q000737:chemistry*; D018139:Simplexvirus / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011498:Protein Precursors