title: [Clinical course and treatment of Hodgkin's disease with concomitant bone marrow lesions].
abstract: Fifty patients with confirmed local multiple lesions of bone marrow were selected by 99mTc scintigraphy, magnetic resonance imaging and morphologically-supported trepan biopsy from 155 cases of Hodgkin's disease stage II-IVAB. Bone marrow lesions were relatively more common in younger patients 1-11 months after primary tumor detection (an average of 6.5 months). They were detected within 12-156 months (an average of 48 months) among relapsing patients with nodal sclerosis and mixed-cell tumors stage III-IVAB, mostly concomitant with anemia and lymphopenia. Standard combination chemotherapeutical regimens for primary patients (MOPP, ABVD and LOPP) and relapsing ones (CCNU-OPP and ABVD) were effective in those with bone marrow lesions. Side-effects (myelodepression) did not exceed normal levels, provided human recombinant interleukin-1 beta (beta-leukin) was administered for protection and leukopoietic stimulation.
authors.affiliation: N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
authors.forename: M L
authors.initials: ML
authors.lastname: Gershanovich
authors.forename: S V
authors.initials: SV
authors.lastname: Kanaev
authors.forename: L V
authors.initials: LV
authors.lastname: Filatova
authors.forename: S N
authors.initials: SN
authors.lastname: Novikov
authors.forename: E E
authors.initials: EE
authors.lastname: Leenman
authors.forename: K M
authors.initials: KM
authors.lastname: Pozharisskiĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D019046:Bone Marrow Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000627:therapeutic use; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D007375:Interleukin-1