Transplantation for accidental acute high-dose total body neutron- and gamma-radiation exposure.
Accidental exposure to acute high-dose total body neutron radiation is rare. We report a 35-year-old man exposed to a total body dose of 5.4 Gy neutron- and 8.5-13 Gy gamma-radiation in a radiation criticality accident. He received a blood stem cell transplant from his HLA-identical sister. There was bone marrow recovery with complete donor chimerism. Random chromatid breaks were observed in donor cells suggesting a bystander effect of neutron exposure. The subject died 82 days after the accident (75 days post transplant) from multi-organ failure.
Chiba
S
S
Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan.
Saito
A
A
Ogawa
S
S
Takeuchi
K
K
Kumano
K
K
Seo
S
S
Suzuki
T
T
Tanaka
Y
Y
Saito
T
T
Izutsu
K
K
Yuji
K
K
Masuda
S
S
Futami
S
S
Nishida
M
M
Suzuki
G
G
Gale
R P
RP
Fukayama
M
M
Maekawa
K
K
Hirai
H
H
D000328:Adult; D001853:Bone Marrow; D002842:Chromatids / Q000528:radiation effects; D005214:Fast Neutrons / Q000009:adverse effects*; D017809:Fatal Outcome; D005720:Gamma Rays / Q000009:adverse effects*; D006085:Graft Survival; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D011210:Power Plants; D011829:Radiation Dosage; D018788:Radioactive Hazard Release; D018183:Transplantation Chimera