title: The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system.
abstract: The role of gp130 in cerebral cortical histogenesis remains unknown. Mice lacking gp130 showed a hypoplastic cortical plate and decreased incorporation of 5-bromo-2'-deoxyuridine (BrdU) in progenitor cells of the developing cerebrum. In contrast, injection of leukemia inhibitory factor (LIF), a gp130 ligand, into the lateral cerebral ventricle of wild-type embryos exo utero induced hyperplasia of the cerebral cortex and increased the incorporation of BrdU in progenitor cells. Furthermore, chronologically controlled injection of LIF followed or preceded by BrdU revealed that gp130-mediated signals promote the progenitor cells to reenter the stem cell cycle without affecting the duration of cell cycle and enhance the migration of postmitotic neurons in the developing cerebrum.
authors.affiliation: Department of Anatomy, Shimane Medical University, Izumo 693-8501, Japan. thatta@shimane-med.ac.jp
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Hatta
authors.forename: Kenji
authors.initials: K
authors.lastname: Moriyama
authors.forename: Kinichi
authors.initials: K
authors.lastname: Nakashima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Taga
authors.forename: Hiroki
authors.initials: H
authors.lastname: Otani
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000166:cytology / Q000196:embryology*; D002552:Cerebral Ventricles / Q000166:cytology / Q000187:drug effects / Q000196:embryology; D050822:Cytokine Receptor gp130; D004622:Embryo, Mammalian / Q000166:cytology / Q000187:drug effects; D005260:Female; D006131:Growth Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000008:administration & dosage / Q000494:pharmacology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008813:Mice, Inbred ICR; D018345:Mice, Knockout; D008845:Microinjections; D008938:Mitosis; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010641:Phenotype; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology; D013687:Telencephalon / Q000166:cytology / Q000196:embryology / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D006131:Growth Inhibitors; C494200:Il6st protein, mouse; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D008222:Lymphokines; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130