[Significance of the changes of plasma endothelin, norepinephrine and atrial natriuretic peptide in treatment of heart failure with beta-blocker].
Thirty patients with chronic heart failure after conventional treatment for two weeks with cardiac diuretic and vasodilator were divided into two groups. There was addition of betaloc into Group A, but Group B kept the original treatment plan for 8 weeks. Group C consisted of 16 normal controls. The results showed that: 1. The level of plasma endothelin(ET), norepinephrine(NE), atrial natriuretic peptide(ANP) in Group A and B were higher than those in Group C. 2. The decreasing degrees of ET, NE, ANP, heart function score and the increasing degrees of CI and LVEF in Group A were more than those in Group B. 3. The change of ET was related to the changes of the others. Therefore, the beta-blocker may be associated with the decrease of the plasma concentration of ET, NE and ANP and improve heart function. It is considered that the degree of change of plasma ET may be the simple and reliable index which evaluate the degree of improving heart function.
Li
G
G
Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Xie
X
X
Zhou
H
H
Huang
Y
Y
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000150:complications; D016232:Endothelins / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D016232:Endothelins; D009320:Atrial Natriuretic Factor; D008790:Metoprolol; D009638:Norepinephrine