title: The efficacy of lafutidine in improving preoperative gastric fluid property: a comparison with ranitidine and rabeprazole.
abstract: Acid aspiration syndrome remains a potentially critical perioperative complication. We compared lafutidine, ranitidine, and rabeprazole for reduction of preoperative gastric fluid acidity and volume in elective surgery and found that these variables were minimized with a single morning dose of lafutidine 20 mg compared with ranitidine or rabeprazole. Preoperative oral lafutidine may be an alternative to ranitidine as a prophylaxis against aspiration pneumonia.
authors.affiliation: Department of Anesthesia and Perioperative Medicine, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kusunoki-cho 7, Chuo-ku, Kobe 650-0017, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Uesugi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Mikawa
authors.forename: Kahoru
authors.initials: K
authors.lastname: Nishina
authors.forename: Osamu
authors.initials: O
authors.lastname: Morikawa
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Takao
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Obara
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005744:Gastric Acid / Q000502:physiology*; D005745:Gastric Acidity Determination; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007431:Intraoperative Complications / Q000453:epidemiology; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000031:analogs & derivatives; D010880:Piperidines / Q000627:therapeutic use*; D011300:Preoperative Care; D054328:Proton Pump Inhibitors; D011725:Pyridines / Q000627:therapeutic use*; D064750:Rabeprazole; D011899:Ranitidine / Q000627:therapeutic use*; D018570:Risk Assessment; D013270:Stomach / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000081:Acetamides; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D006635:Histamine H2 Antagonists; D010880:Piperidines; D054328:Proton Pump Inhibitors; D011725:Pyridines; D064750:Rabeprazole; C076948:lafutidine; D011899:Ranitidine; D009853:Omeprazole