Effect of octreotide acetate on the plasma concentration and urinary excretion of uridine and purine bases.
To determine the effect of octreotide acetate on urinary excretion of uric acid and plasma concentration of uridine, we subcutaneously administered octreotide acetate (1 microg/kg of body weight) to 5 healthy subjects. Ninety minutes after administration, octreotide acetate increased the plasma concentration of uridine by 15% and decreased the plasma concentration of glucagon by 24% and that of insulin to below the detection limits. In addition, octreotide acetate decreased the urinary excretion of uric acid, sodium, and chloride by 60%, 40%, and 38%, respectively, at 1 hour after administration. However, octreotide acetate did not affect the concentrations of hypoxanthine, xanthine, uric acid, cyclic AMP in plasma, lactic acid and pyruvic acid in blood, urinary excretion of hypoxanthine and xanthine, or creatinine clearance. From these results, we speculated that octreotide acetate decreases the urinary excretion of uric acid by decreasing the concentration of glucagon and/or urinary excretion of sodium, and increases the plasma concentration of uridine via decreased concentrations of glucagon and insulin.
Yamamoto
Tetsuya
T
Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Moriwaki
Yuji
Y
Takahashi
Sumio
S
Tsutsumi
Zenta
Z
Ka
Tsuneyoshi
T
Hada
Toshikazu
T
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002712:Chlorides / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000652:urine; D000242:Cyclic AMP / Q000097:blood; D005934:Glucagon / Q000097:blood; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008875:Middle Aged; D015282:Octreotide / Q000494:pharmacology*; D011687:Purines / Q000097:blood* / Q000652:urine; D019289:Pyruvic Acid / Q000097:blood; D012964:Sodium / Q000097:blood / Q000652:urine; D014529:Uridine / Q000097:blood* / Q000652:urine
D001786:Blood Glucose; D002712:Chlorides; D006728:Hormones; D007328:Insulin; D011687:Purines; D019344:Lactic Acid; D019289:Pyruvic Acid; D005934:Glucagon; D012964:Sodium; D003404:Creatinine; D000242:Cyclic AMP; D015282:Octreotide; D014529:Uridine