[Enhancement of antioxidant status of the elderly patients with ischemic heart disease in response to amino acid composition of MP-33 in combined therapy with trimetazidine].
Effects of amino acid composition MP-33 in combination with trimetazidine were studied in metabolic therapy of elderly patients (age 63.3 +/- 1.7 years) with ischemic heart disease (angina pectoris functional class II-III). MP-33 (100 mg 3 times a day subling.), trimetazidine (20 mg 3 times a day per os), trimetazidine + amino acid composition MP-33 in the above doses in addition to basic therapy were given to 30, 15 and 15 patients, respectively. Combined therapy with trimetazidine and MP-33 significantly activated antioxidant enzymes and depressed lipid peroxidation due to GSH-dependent regulation of cellular redox status by MP-33.
Kalinina
E B
EB
Komissarova
I A
IA
Zaslavskaia
R M
RM
Zhdanov
Iu A
IuA
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism*; D011506:Proteins; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D014292:Trimetazidine / Q000494:pharmacology* / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use*
D000975:Antioxidants; C119710:MP-33; D011506:Proteins; D011837:Radiation-Protective Agents; D014665:Vasodilator Agents; D014292:Trimetazidine