Oxidant signalling in carcinogenesis: a commentary.
It is becoming increasingly evident that reactive oxygen species (ROS) act at different stages of carcinogenesis, and thus play multiple roles in oncogenesis. In addition to being mutagenic and initiating tumors, ROS or carcinogens that result in ROS generation may affect tumor promotion and progression through varied effects on growth promoting, growth inhibitory, or apoptotic signaling pathways.
Deshpande
S S
SS
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Irani
K
K
D017209:Apoptosis / Q000187:drug effects; D002273:Carcinogens / Q000009:adverse effects; D009369:Neoplasms / Q000139:chemically induced*; D016877:Oxidants / Q000009:adverse effects*; D017382:Reactive Oxygen Species / Q000009:adverse effects*; D015398:Signal Transduction / Q000187:drug effects*
D002273:Carcinogens; D016877:Oxidants; D017382:Reactive Oxygen Species