title: Management of uterine leiomyomata: what do we really know?
abstract: OBJECTIVE
  To systematically review the literature on the surgical and nonsurgical management of uterine leiomyomata.
  
  
  METHODS
  Published literature in English on the management of uterine leiomyomata published from 1975 through 2000 was identified in MEDLINE, CINAHL, CancerLit, EMBASE, HealthSTAR, and the Cochrane Database of Systematic Reviews. Search terms included "leiomyomata," "fibroids," "hysterectomy," and "myomectomy."
  
  
  METHODS
  Study designs considered included controlled trials, prospective trials with historical controls, prospective or retrospective cohort studies, and series with at least 20 cases. Original research studies or relevant reviews were included if the study population included women with uterine leiomyomata, and data were provided relevant to one or more of nine prespecified research questions.
  
  
  RESULTS
  Inconsistency in reporting of severity of symptoms, uterine anatomy, and response to therapy prevented meaningful comparison of studies in most cases, and prevented performance of meta-analysis in all cases. This was true of both surgical and nonsurgical treatments.
  
  
  CONCLUSIONS
  The available evidence on the management of uterine leiomyomata is of poor quality. Patients, clinicians, and policymakers do not have the data needed to make informed decisions about appropriate treatment. Given the prevalence of this condition and its substantial impact on women's lives, obtaining these data should be a high research priority.
authors.affiliation: Evidence-Based Practice Center, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Evan R
authors.initials: ER
authors.lastname: Myers
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Barber
authors.forename: Tara
authors.initials: T
authors.lastname: Gustilo-Ashby
authors.forename: Grace
authors.initials: G
authors.lastname: Couchman
authors.forename: David B
authors.initials: DB
authors.lastname: Matchar
authors.forename: Douglas C
authors.initials: DC
authors.lastname: McCrory
mesh_terms: D000328:Adult; D018849:Controlled Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D053685:Laser Therapy / Q000379:methods; D007889:Leiomyoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*