title: Longterm decrease in the CD57 lymphocyte subset in a patient with chronic Lyme disease.
abstract: Lyme disease is a tickborne illness caused by the spirochete Borrelia burgdorferi. In a previous report we described a decrease in the CD57 lymphocyte subset in patients with chronic Lyme disease. We have now identified a patient with chronic relapsing and remitting symptoms of Lyme disease who had decreased levels of CD57 lymphocytes over 10 years. This observation represents the longest duration of an immunologic abnormality ever documented in chronic Lyme disease. The CD57 lymphocyte subset appears to be a useful marker of longterm infection with the Lyme disease spirochete.
authors.affiliation: California Pacific Medical Center, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA. rstricker@usmamed.com
authors.forename: Raphael B
authors.initials: RB
authors.lastname: Stricker
authors.forename: Joseph
authors.initials: J
authors.lastname: Burrascano
authors.forename: Edward
authors.initials: E
authors.lastname: Winger
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018959:CD57 Antigens / Q000276:immunology*; D020682:Cefixime / Q000627:therapeutic use; D002908:Chronic Disease; D017291:Clarithromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000188:drug therapy / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; D018959:CD57 Antigens; D020682:Cefixime; D017291:Clarithromycin