Interhemispheric reorganization of motor hand function to the primary motor cortex predicted with functional magnetic resonance imaging and transcranial magnetic stimulation.
The objective of this study was presurgical assessment of reorganization of motor hand function in an 11-year-old girl with intractable epilepsy and a right-sided hemiplegia resulting from an extensive perinatal left hemispheric stroke. Prior to a left functional hemispherectomy, functional magnetic resonance imaging (MRI) showed that both nonparetic and paretic motor hand function predominantly activated the right primary motor cortex, whereas no activation was found in the left hemisphere. Transcranial magnetic stimulation of the right central area yielded responses in both the nonparetic and the paretic hand, whereas no responses were obtained after stimulation of the affected hemisphere. Both techniques indicated that motor function was mediated by corticospinal fibers originating from the undamaged (primary) motor cortex and predicted no further loss of motor hand function after surgery. Indeed, subsequent functional hemispherectomy induced no new sensorimotor deficits. Functional MRI was repeated 22 months after surgery and matched preoperative sensorimotor functional MRI findings, confirming reorganization of the primary motor cortex. No additional reorganization was introduced by surgery.
Rutten
Geert-Jan M
GJ
Department of Neurosurgery, University Medical Center Utrecht, The Netherlands. g.rutten@neuro.azu.nl
Ramsey
Nick F
NF
van Rijen
Peter C
PC
Franssen
Hessel
H
van Veelen
Cees W M
CW
D020520:Brain Infarction / Q000150:complications / Q000503:physiopathology*; D002648:Child; D004574:Electromagnetic Fields; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006225:Hand / Q000294:innervation* / Q000503:physiopathology; D006429:Hemiplegia / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000503:physiopathology*; D009473:Neuronal Plasticity; D010812:Physical Stimulation