Fibrosis and atrophy in the renal allograft: interim report and new directions.
The topic of chronic allograft nephropathy/chronic rejection is reviewed, with focus on fibrosing/sclerosing changes and late loss of function in renal allografts. Discussion includes a review of the problem, pathological and clinical findings, and new directions. Emphasis is placed on definition of specific diagnostic entities in these allografts, and identification of ongoing/active processes in this setting that might be amenable to direct intervention. A schema for categorizing these cases is proposed.
Racusen
Lorraine C
LC
The Johns Hopkins Medical Institutions, Baltimore, MD, USA. lracusen@jhmi.edu
Solez
Kim
K
Colvin
Robert
R
D001284:Atrophy; D005355:Fibrosis; D006084:Graft Rejection / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000473:pathology*; D014184:Transplantation, Homologous / Q000473:pathology; D017211:Treatment Failure