[The response to normobaric hypoxia and its duration in arterial hypertension patients as shown by a prospective study].
A placebo-controlled parallel trial studied an antihypertensive action of interrupted normobaric hypoxia (INH) in 63 male patients with arterial hypertension (AH) of the first degree and low and moderate risk of vascular complications. The placebo group consisted of 18 patients with AH of the first degree matched by age, the disease duration, initial level of systolic and diastolic pressure. An INH course consisted of 15 daily procedures. INH monotherapy implied oxygen content lowering to 10%. A 6-month follow-up was made with the use of 24-h AP monitoring. The INH course resulted in a significant decrease in systolic and diastolic AP, total peripheral vascular resistance. A morning rise of systolic pressure became slower. A favourable effect of normobaric hypoxia on AP 24-h rhythm was observed. A good hypotensive effect was achieved in 85.7% patients. A 6-month follow-up confirmed a long-term hypotensive effect of INH.
Velizhanina
I A
IA
Evdokomova
O V
OV
Gapon
L I
LI
Vdovenko
S V
SV
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D000860:Hypoxia / Q000453:epidemiology* / Q000517:prevention & control; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D013997:Time Factors
D000959:Antihypertensive Agents; D010100:Oxygen