Hypoglycemic effect of a Lentinus edodes exo-polymer produced from a submerged mycelial culture.
The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of Lentinus edodes was investigated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. Gel chromatography of the exo-polymer revealed a single peak which is likely to have been a glycoprotein with a molecular weight of 52 kDa and was found to contain 83.5% carbohydrate and 16.5% protein. The Sugar and amino acid compositions of the exo-polymer were analyzed in detail.
Yang
Byung-Keun
BK
Department of Biotechnology, Taegu University, Kyungsan, Kyungbuk, South Korea.
Kim
Dong-Hyun
DH
Jeong
Sang-Chul
SC
Das
Surajit
S
Choi
Young-Sun
YS
Shin
Joon-Shik
JS
Lee
Sang-Chul
SC
Song
Chi-Hyun
CH
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001704:Biopolymers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002850:Chromatography, Gel; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005247:Feeding Behavior / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020942:Shiitake Mushrooms / Q000737:chemistry*; D013311:Streptozocin
D001704:Biopolymers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013311:Streptozocin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase