[Lymphocyte traffic in the events that follow lymphocytes activation in the germinal centre].
After their maturation, lymphocytes migrate from the primary lymphoid organs to the secondary lymphoid organs and tissues. Once in the secondary tissues the lymphocytes do not simply remain there; many move from one lymphoid organ to another via the blood and lymph. This process allows a large number of antigen-specific lymphocytes to come in contact with their appropriate antigen in the microenvironment of the peripheral lymphoid organs and this is important since lymphocytes are monospecific and only a limited number of cells are able to recognize and interact with a particular antigen. When B cells are activated by antigen, with the help from the T cells, they mature either into AFCs (Antibody-Forming Cells), or they develop into memory cells. The germinal centers in various lymphoid tissues represent the sites of the immune response development and memory B cells generation. At these sites, the B cells undergo active hypermutation of the variable genes, a process that can lead to death by apoptosis for some cells.
Cianga
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Facultatea de Medicină Stomatologică, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
Cianga
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D001402:B-Lymphocytes / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D018858:Germinal Center / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D009154:Mutation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology