Germline stem cell transplantation and transgenesis.
The recently developed testis cell transplantation method provides a powerful approach to studying the biology of the male germline stem cell and its microenvironment, the stem cell niche. The technique also is being used to examine spermatogenic defects, correct male infertility, and generate transgenic animals.
Brinster
Ralph L
RL
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3850 Baltimore Avenue, Philadelphia, PA 19104, USA.
D000818:Animals; D002454:Cell Differentiation; D002469:Cell Separation; D002478:Cells, Cultured; D015925:Cryopreservation; D006801:Humans; D008297:Male; D012671:Seminiferous Tubules / Q000166:cytology; D012708:Sertoli Cells / Q000502:physiology; D013091:Spermatogenesis; D013093:Spermatogonia / Q000166:cytology* / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology; D013737:Testis / Q000166:cytology*; D014161:Transduction, Genetic; D019076:Transgenes; D014183:Transplantation, Heterologous