A cellular cofactor in HIV-1 assembly: INI1 is also an "outtie".
Recent findings have shed light on the previously poorly understood process by which HIV is assembled and released from infected cells. The host cell cofactor integrase interactor 1 (INI1), which was previously shown to chaperone the covalent linkage of the viral genome to the chromosomal DNA of the cell, also appears to assist in virus assembly. Another host cofactor, TSG101, that functions in vacuolar protein sorting has been found to play a key role in virus budding.
Landau
Nathaniel R
NR
D004268:DNA-Binding Proteins / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D015497:HIV-1 / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D014779:Virus Replication; D000099177:Tsg101 Protein
D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D014157:Transcription Factors; D000099177:Tsg101 Protein