Systemic inflammatory response associated with augmentation and activation of leukocytes in Candida/indomethacin administered mice.
We have previously shown that the combination of beta-glucan and nonsteroidal anti-inflammatory drugs (NSAIDs) was lethal to mice. In this study, we examined the effect of Candida on this treatment and found that Candida showed similar lethal toxicity when used in combination with indomethacin. It was also confirmed that LPS preparations from various origins and by various procedures did not show lethality. Candida/indomethacin induced lethality was found to be associated with increased number of leukocytes in various organs and activation of these cells. These findings strongly suggest that pathogenic fungi augment the side effects of non-steroidal anti-inflammatory drugs.
Moriya
Keisuke
K
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Miura
Noriko N
NN
Adachi
Yoshiyuki
Y
Ohno
Naohito
N
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001831:Body Temperature / Q000187:drug effects; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002175:Candida / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D005936:Glucans / Q000633:toxicity; D006861:Hydrogen Peroxide / Q000378:metabolism; D007202:Indicators and Reagents; D007213:Indomethacin / Q000633:toxicity*; D007249:Inflammation / Q000473:pathology*; D018836:Inflammation Mediators / Q000502:physiology; D007371:Interferon-gamma / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007962:Leukocytes / Q000473:pathology*; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005936:Glucans; D007202:Indicators and Reagents; D018836:Inflammation Mediators; D015850:Interleukin-6; D008070:Lipopolysaccharides; D007371:Interferon-gamma; D006861:Hydrogen Peroxide; D007213:Indomethacin