title: The role of brachytherapy in the management of oropharyngeal carcinomas: the Trento experience.
abstract: OBJECTIVE
  This study was undertaken to determine the outcome of patients with oropharyngeal cancer treated at the Radiotherapy Department of the Santa Chiara Hospital (Trento, Italy) with brachytherapy alone or combined with external beam radiotherapy (EBRT).
  
  
  METHODS
  We retrospectively reviewed the medical records of 87 patients with squamous cell carcinoma of the oropharynx treated by radiation therapy between January 1986 and September 1999. The median age was 59 years and all patients had a minimum follow-up of one year. Tumor locations were 46 tonsillar region, 31 soft palate and 10 base of the tongue. The patients were staged as follows: 41 T1, 35 T2, 11 T3 with 70 N0, 9 N1 and 8 N2. They received either brachytherapy alone (14 patients) or a combination of external beam irradiation and brachytherapy (73 patients) using an afterloading iridium technique in a plastic tube.
  
  
  RESULTS
  Overall primary tumor control, including salvage surgery, was 81/87 (93%). Control of metastatic cervical adenopathy was as follows: clinical stage N1, 5/9 patients; N2, 2/8 patients. The estimated five-year cause-specific survival and overall survival rates were 81% and 47%, respectively. After interstitial irradiation severe complications were limited to one case of osteoradionecrosis of the mandible and seven cases of mucosal ulcer.
  
  
  CONCLUSIONS
  This study confirms that iridium-192 interstitial implant alone or as a boost after external beam irradiation is a safe and effective therapy in the management of oropharyngeal carcinomas.
authors.affiliation: Division of Radiotherapy, Ospedale S Chiara, Trento, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bolner
authors.forename: Salvatore
authors.initials: S
authors.lastname: Mussari
authors.forename: Gianni
authors.initials: G
authors.lastname: Fellin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pani
authors.forename: Lucia
authors.initials: L
authors.lastname: Busana
authors.forename: Orazio
authors.initials: O
authors.lastname: Caffo
authors.forename: Luigi
authors.initials: L
authors.lastname: Tomio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011832:Radiation Injuries; D012189:Retrospective Studies; D016019:Survival Analysis