title: AbrB is a regulator of the sigma(W) regulon in Bacillus subtilis.
abstract: The Bacillus subtilis global regulator AbrB was found to negatively control expression of sigW and genes of the sigma(W) regulon. AbrB bound to DNA regions in the autoregulatory sigW promoter and to some, but not all, of the other sigma(W)-dependent promoters in B. subtilis. Defects in antibiotic resistance properties caused by spo0A mutations are at least partially correlated with AbrB repression of the sigma(W) regulon.
authors.affiliation: Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W. Baltimore St., Room 4-C-30, Baltimore, MD 21201, USA.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Qian
authors.forename: Chien Y
authors.initials: CY
authors.lastname: Lee
authors.forename: John D
authors.initials: JD
authors.lastname: Helmann
authors.forename: Mark A
authors.initials: MA
authors.lastname: Strauch
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D015536:Down-Regulation; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D018085:Regulon; D012808:Sigma Factor / Q000235:genetics* / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: C060762:AbrB protein, Bacillus subtilis; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C413458:SigW protein, Bacillus subtilis; D012808:Sigma Factor; D014157:Transcription Factors