title: [Clinico-microbiological comments on various cases of candidemia].
abstract: During a 3 year period 48 patients with one or more blood cultures positive for Candida spp. were enrolled in the study. One patient presented 3 consecutives episodes of candidemia with infection of the port a cath. Fifty cases of candidemia were diagnosed. Candidemia with infection of the central venous catheter was the most frequent diagnosis (52%); in 20% of cases a tissue localization was also present (disseminated candidiasis). Thirty-four out of 50 episodes occurred in the Surgical Department. Among risk factors the most frequent resulted: prolonged antibiotic treatment (100%), intravascular catheter (86%), parenteral nutrition (74%), abdominal surgery (46%). C. albicans was identified more frequently than others Candida spp., resistance to fluconazole was detected in 20% of strains tested. 34/45 episodes of fungemia were treated with fluconazole, none reported side effects. In 5 cases fluconazole was discontinued for clinical failure. Clinical outcome in patients with Candida infection depends on other factors beside in vitro drug susceptibility tests.
authors.affiliation: Sezione di Clinica di Malattie Infettive, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Policlinico Monteluce, Università, Perugia. pasticci@unipg.it
authors.forename: Maria Bruna
authors.initials: MB
authors.lastname: Pasticci
authors.forename: Sonia
authors.initials: S
authors.lastname: Guerrieri
authors.forename: Angela
authors.initials: A
authors.lastname: Cardaccia
authors.forename: Amedeo
authors.initials: A
authors.lastname: Moretti
authors.forename: Rita
authors.initials: R
authors.lastname: Papili
authors.forename: Antonella
authors.initials: A
authors.lastname: Repetto
authors.forename: Giuliano
authors.initials: G
authors.lastname: Stagni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged