Solid-phase synthesis of n,n-disubstituted s,n'-diarylisothioureas: facile exchange reactions of isocyanates.
Reactions of resin-bound 1,1-disubstituted-2-arylisothioureas 4aa',ab'-ec' with aryl isocyanates, diversely substituted at the para and/or meta positions, and with o-fluoro- and 2,4-difluorophenyl isocyanate followed by appropriate cleavage led to the formation of N,N-disubstituted S,N'-diarylisothioureas 9[1-70] in good yields and high purities.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
Vvedensky
Vladimir
V
Rogovoy
Boris V
BV
Kovalenko
Katherine
K
Torres
Eduardo
E
Forood
Behrouz
B