title: [SV40 and cell immortalization].
abstract: OBJECTIVE
  To explore the SV40-mediated immortalization, the related factors and their roles in cell immortalization.
  
  
  METHODS
  The original articles about cell immortalization and replicative senescence in recent decade were reviewed.
  
  
  RESULTS
  Cell immortalization was a multifaceted phenomenon, it was involved in viral DNA integration, activation of telomerase, inactivation of growth suppressors, and so on, and their roles were closely related.
  
  
  CONCLUSIONS
  The research on cell immortalization may be expected to provide important insights into a broad range of cellular biological phenomenon, and the immortalized cells can play important roles in the research of cell engineering and tissue engineering as standard cells.
authors.affiliation: Department of Orthopedic Surgery, First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, P. R. China 610041.
authors.forename: H Q
authors.initials: HQ
authors.lastname: Xie
authors.forename: Z M
authors.initials: ZM
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Qu
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D016922:Cellular Senescence; D004847:Epithelial Cells; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D013539:Simian virus 40