Tiny dancers: the integrin-growth factor nexus in angiogenic signaling.
A vital step in growth factor-driven angiogenesis is the coordinated engagement of endothelial integrins with the extracellular matrix. The molecular mechanisms that partner growth factors and integrins are being elucidated, revealing an intricate interaction of surface receptors and their signaling pathways.
Smyth
Susan S
SS
Department of Medicine (Cardiology) and The Carolina Cardiovascular Biology Center, The University of North Carolina, Chapel Hill, NC 27599, USA.
Patterson
Cam
C
D000818:Animals; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D015398:Signal Transduction
D006133:Growth Substances; D016023:Integrins