[Experimental and clinical study to remove lead and to prevent lead damage of kidney with salt of high dose KI].
OBJECTIVE
To study and make a salt prevent lead poisoning.


METHODS
SD rats were given 0.25% lead acetate by food intake and were given 10 mg.kg-1.d-1, 20 mg.kg-1.d-1 and 30 mg.kg-1.d-1 potassium iodide from drinking water in respective groups, in order to look for the dose of KI which prevents lead poisoning. The salt to prevent lead poisoning was made, 50 workers were given the salt as to flavouring of daily food intake. PbB, Pbu, ZPP, delta-ALA, NAG(N-acetyl-beta-D-glucosaminidase), RP(Retinol protein) were observed.


RESULTS
The dose of KI to prevent experimental lead poisoning of SD rats was 10 mg.kg-1.d-1 by oral intake. People who contacted lead had an increase of urine lead in the third day, and had most urine lead on ninth day after taking the salt with KI. Normal urine lead on the fourth week. Pre- and post-oral intake of the salt with high dose KI, Hb, ZPP, delta-ALA, PbB, NAG and Rp the people mentioned above had the following indexes, (101.2 and 128) g.L-1 (P = 0.05), (33.5 and 7.7) micrograms.g-1 Hb(P < 0.01), (123.12 and 65.35) mumol.L-1 (P < 0.05), (2.123 and 0.85) mumol.L-1 (P < 0.01), (20.9 and 6.7) U.L-1 (P < 0.01), (1.5 and 0.34) mg.L-1 (P < 0.05) respectively.


CONCLUSIONS
The salt with 1% KI may remove lead and prevent lead damage of the kidney.
Hu
Y
Y
Department of Nephrology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Jiang
Y
Y
Tan
D
D
D000293:Adolescent; D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007854:Lead; D007855:Lead Poisoning / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D008906:Mining; D016273:Occupational Exposure; D011193:Potassium Iodide / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary
D017673:Sodium Chloride, Dietary; D011193:Potassium Iodide; D007854:Lead