[Histological changes of Cysticercus cellulosae under the action of proteinase of Omphalia lapidescens in vitro].
OBJECTIVE
For the purpose of finding an anthelmintic with high efficacy, low toxicity and low cost, especially from the Chinese traditional medicines.


METHODS
Forty Cysticercus cellulosae were separately incubated with proteinase from artificially fermented Omphalia lapidescens for 2 h, 4 h and 8 h, and then examined for histological changes by light microscopy and compared with those of proteinase from natural dry Omphalia lapidescens after similar treatment.


RESULTS
Cysticercus cellulosae were morphologically and structurally impaired after exposure to the action of proteinase of Omphalia lapidescens, and the degree of impairment was proportionally paralleled to the duration of treatment.


CONCLUSIONS
The anti-cysticercus effect of proteinase of Omphalia lapidescens and the homogeneity of proteinases from artificially fermented and natural Omphalia lapidescens were confirmed.
Zhao
G
G
Beijing Tropical Medicine Research Institute, Beijing 100050.
Xu
Z
Z
Feng
M
M
You
J
J
Guo
M
M
Li
H
H
D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D003551:Cysticercosis / Q000469:parasitology / Q000662:veterinary; D003552:Cysticercus / Q000033:anatomy & histology* / Q000302:isolation & purification / Q000648:ultrastructure; D010450:Endopeptidases / Q000302:isolation & purification / Q000494:pharmacology*; D013553:Swine Diseases / Q000469:parasitology
D000871:Anthelmintics; D010450:Endopeptidases