title: Successful treatment of refractory disseminated Mycobacterium avium complex infection with the addition of linezolid and mefloquine.
abstract: Execpt in patients with AIDS, disseminated MAC infection has been rare. We describe a patient with chronic lymphatic leukemia who developed disseminated cutaneous MAC lesions refractory to conventional antimycrobial therapy. The lesions responded to the addition of compounds that were recently discovered to have anti-MAC activity (linezolid, moxifloxacin) as well as GM-CSF.
authors.affiliation: Department of Infectious Diseases, The University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Esteban C
authors.initials: EC
authors.lastname: Nannini
authors.forename: Michael
authors.initials: M
authors.lastname: Keating
authors.forename: Peter
authors.initials: P
authors.lastname: Binstock
authors.forename: George
authors.initials: G
authors.lastname: Samonis
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001372:Aza Compounds; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004977:Ethambutol / Q000627:therapeutic use; D017809:Fatal Outcome; D024841:Fluoroquinolones; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D000069349:Linezolid; D008297:Male; D015767:Mefloquine / Q000627:therapeutic use*; D008875:Middle Aged; D000077266:Moxifloxacin; D015269:Mycobacterium avium Complex / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D023303:Oxazolidinones / Q000627:therapeutic use*; D011804:Quinolines
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D023303:Oxazolidinones; D011804:Quinolines; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D004977:Ethambutol; D017291:Clarithromycin; D000069349:Linezolid; D015767:Mefloquine; D000077266:Moxifloxacin