Cytotoxic anthraquinone derivatives from Picramnia antidesma.
Activity-guided investigation of crude extracts prepared from the root bark of Picramnia antidesma, a medicinal plant long used for the treatment of malaria in tropical areas of the Americas, when tested on KB cells led to the isolation of a new compound, 10-epi-uveoside, from a cytotoxic fraction containing a rich mixture of anthrone glycosides. The antiplasmodial activity proved to be a result of the high levels of cytotoxicity displayed by the anthraquinone derivatives and therefore infusions from this crude drug lack the selectivity index needed to be an effective antimalarial agent.
Hernández-Medel
María del Rosario
Mdel R
Pereda-Miranda
Rogelio
R
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002489:Central America; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D019684:Magnoliopsida; D008519:Medicine, Traditional; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D018675:Toxicity Tests; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014900:West Indies
D000880:Anthraquinones; D010936:Plant Extracts