title: [The role of PET scan in the investigation of the lymphatic spreading of Hodgkin's disease].
abstract: The authors investigated the role of PET, as a non-invasive diagnostic method, in the analysis of lymphatic spreading of Hodgkin's disease (HD). Whole-body FDG scans were carried out in 71 patients along with [11C]-methionine examinations, if necessitated by inconclusive FDG results. Based on these findings involvement-frequencies were calculated for each lymphatic region. The three most frequently involved lymphatic regions were the mediastinum (83.1%), the left cervical and left supraclavicular regions (78.9%) and the right cervical and right supraclavicular regions (76.1%). These data support the hypothesis that HD originates from the cervical or supraclavicular regions and reaches the distant sites by basically retrograde spreading in a non-random manner. The appropriate values of site involvement-rate were compared with those obtained by other authors based on pathologic staging and a good correlation was found. The high level of correspondence between these involvement-frequencies supported the general validity (i.e. valid for both treated and untreated cases) of the principles governing lymphatic spreading of HD.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, PET Centrum, Debrecen. hegel@pet.dote.hu
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lengyel
authors.forename: András
authors.initials: A
authors.lastname: Rosta
authors.forename: Beáta
authors.initials: B
authors.lastname: Deák
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Molnár
authors.forename: Tamás
authors.initials: T
authors.lastname: Schneider
authors.forename: Erika
authors.initials: E
authors.lastname: Várady
authors.forename: Olga
authors.initials: O
authors.lastname: Esik
authors.forename: Judit
authors.initials: J
authors.lastname: Székely
authors.forename: Lajos
authors.initials: L
authors.lastname: Trón
mesh_terms: D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18