title: [Therapy of hepatitis C].
abstract: Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Here, we will briefly review current and evolving therapies for chronic hepatitis C. Standard therapy with (pegylated) interferon-alpha and ribavirin achieves sustained response rates of up to about 40% in genotype 1- and about 80% in genotype 2- and 3-infected patients. Recent progress in the molecular virology and pathogenesis of hepatitis C has allowed the identification of novel antiviral targets and therapeutic strategies. These will likely complement existing therapeutic modalities in the near future.
authors.affiliation: Abteilung Innere Medizin II, Medizinische Universitätsklinik Freiburg i. Br. moradpou@ruf.uni-freiburg.de
authors.forename: D
authors.initials: D
authors.lastname: Moradpour
authors.forename: H E
authors.initials: HE
authors.lastname: Blum
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use; D008111:Liver Function Tests; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000627:therapeutic use; D011994:Recombinant Proteins; D012254:Ribavirin / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a