BB rat lyp mutation and Type 1 diabetes.
BioBreeding (BB) rats spontaneously develop an autoimmune diabetic syndrome similar to that observed in humans and NOD mice. One of the diabetes susceptibility loci maps to the lyp locus on chromosome 4. In this article we describe the consequences of the BB rat lyp mutation on T-cell homeostasis, repertoire and function, as well as its role in the pathogenesis of type I diabetes.
Ramanathan
S
S
Arthritis and Immune Disorder Research Centre at the University Health Network, University of Toronto, Ontario, Canada.
Poussier
P
P
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008231:Lymphopenia / Q000276:immunology / Q000503:physiopathology; D051379:Mice; D008938:Mitosis; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D051381:Rats; D011922:Rats, Mutant Strains / Q000235:genetics* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
C516765:PTPN22 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D017027:Protein Tyrosine Phosphatases; C516766:Ptpn22 protein, mouse