[Xenogeneic graft-versus-host disease].
OBJECTIVE
To evaluate the histological characteristics of xenogeneic graft-versus-host disease (GVHD), and to differentiate it from the allogeneic GVHD.


METHODS
The original articles related to the characteristics of xenogeneic GVHD and the relationship between xenogeneic GVHD and allogeneic GVHD were widely reviewed in the past decade.


RESULTS
Xenogeneic GVHD was different from allogeneic GVHD in the speed of development, position and features of pathological changes, due to the incompatibility of common simulative signals, adhesive molecules and difference of antigens. Xenogeneic spleen transplantation could induce xenogeneic GVHD.


CONCLUSIONS
Xenogeneic GVHD can be used as a model to mimic rejection in xenotransplantation and to evaluate the compatibility of xenotransplantation.
Wang
K J
KJ
Department of Urinary Surgery, First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, P. R. China 610041.
Li
Y P
YP
Yang
Y R
YR
D000818:Animals; D017690:Cell Transplantation; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D013154:Spleen / Q000166:cytology / Q000637:transplantation*; D014183:Transplantation, Heterologous