Flavonoids with activity against methicillin-resistant Staphylococcus aureus from Dalea scandens var. paucifolia.
Bioassay-guided fractionation of the ethyl acetate extract of the roots of Dalea scandens (Miller) R. Clausen var. paucifolia led to the isolation of new flavonoids, 2( S)-5'-(-1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2',4',5,7-tetrahydroxyflavanone, 2( S)-5'-(1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2'-methoxy-4',5,7-trihydroxyflavanone and 5'-(1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2',4',5,7-tetrahydroxyflavone. Structure elucidation was carried out by spectroscopic methods. All three compounds showed significant activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
Nanayakkara
N P Dhammika
NP
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. dhammika@olemiss.edu
Burandt
Charles L
CL
Jacob
Melissa R
MR
D007887:Fabaceae; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010406:Penicillins / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects*
C465081:2-5'(-1''',1'''-dimethylallyl)-8-(3'',3''-dimethylallyl)-2',4',5,7-tetrahydroxyflavanone; C465082:2-5'-(-1''',1'''-dimethylallyl)-8-(3'',3''-dimethylallyl)-2'-methoxy-4',5,7-tetrahydroxyflavanone; D044950:Flavanones; D005419:Flavonoids; D010406:Penicillins; D010936:Plant Extracts; D008712:Methicillin