title: Is IL12B a potential genetic target for the prevention of type 1 diabetes through dietary intervention?
abstract: Type 1 diabetes mellitus (T1D) results from decreased insulin production. Its clinical expression is the result of an array of genetic and environmental factors. The IL12B gene could be one of the loci implicated in the genetic susceptibility of T1D. Thus, this genetic predisposition could be modulated by dietary factors. However, there is no consistency among populations in relation to relevance of this locus as a candidate gene for T1D.
authors.affiliation: USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ordovas
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Haiqing
authors.initials: H
authors.lastname: Shen
authors.forename: Jean
authors.initials: J
authors.lastname: Mayer
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D018664:Interleukin-12; D053762:Interleukin-12 Subunit p40; D007378:Interleukins / Q000235:genetics*; D008297:Male; D051379:Mice
chemical_list: C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40; D007378:Interleukins; D018664:Interleukin-12