Spontaneous remission of B-cell chronic lymphocytic leukemia associated with T lymphocytic hyperplasia in bone marrow.
Spontaneous remissions in B-cell chronic lymphocytic leukemia (B-CLL) are rare and none of them has been studied with immunophenotyping (by flow cytometry and immunohistochemistry) and genotyping. In this patient, studied after spontaneous remission had occurred, there was a residual T-lymphocytic hyperplasia in the bone marrow with a normal CD4:CD8 ratio. Absolute CD4 and CD8 counts and CD4:CD8 ratio in the peripheral blood were normal. Flow cytometry revealed no B-CLL cells in the peripheral blood and less than 2% B-CLL cells in the bone marrow.
Upshaw
Jefferson D
JD
Memphis Cancer Center, Tenn 38119, USA.
Callihan
Thomas R
TR
D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008297:Male; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000473:pathology*