title: [Clinical evaluation of the effect of tamsulosin hydrochloride and cernitin pollen extract on urinary disturbance associated with benign prostatic hyperplasia in a multicentered study].
abstract: We evaluated the clinical efficacy and safety of tamsulosin hydrochloride and cernitin pollen extract in 243 patients with urinary disturbance associated with benign prostatic hyperplasia. They were assigned randomly to 3 groups, oral tamsulosin hydrochloride, cernitin pollen extract and their combination were administered for 12 weeks. The international prostate symptom score, post-voided residual urine and uroflowmetrogram were obtained before and after treatment. The international prostate symptom score improved in each group and then the maximum flow rate and average flow rate also increased significantly in the tamsulosin hydrochloride-administered groups. In conclusion, the administration of only tamsulosin hydrochloride and the combination of tamsulosin hydrochloride and cernitin pollen extract seemed more effective then the administration of only cernitin pollen extract in the treatment of urinary disturbance associated with benign prostatic hyperplasia.
authors.affiliation: Department of Urology, Yamaguchi University School of Medicine.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Aoki
authors.forename: Katsusuke
authors.initials: K
authors.lastname: Naito
authors.forename: Osamu
authors.initials: O
authors.lastname: Hashimoto
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hara
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Baba
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
authors.forename: Keiji
authors.initials: K
authors.lastname: Joko
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nagao
authors.forename: Gen-ichiro
authors.initials: G
authors.lastname: Yamakawa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Suyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagata
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Matsuyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirao
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hironaka
authors.forename: Riichiro
authors.initials: R
authors.lastname: Isoyama
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takemoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tuchida
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shiraishi
authors.forename: Masahisa
authors.initials: M
authors.lastname: Kato
authors.forename: Yoriaki
authors.initials: Y
authors.lastname: Kamiryo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Harada
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Otsuka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsui
authors.forename: Takashi
authors.initials: T
authors.lastname: Nasu
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Hayashida
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Jojima
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sacho
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Koshido
authors.forename: Noriaki
authors.initials: N
authors.lastname: Harada
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000368:Aged; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000150:complications*; D012434:Secale; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D014555:Urination Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000317:Adrenergic alpha-Antagonists; D010936:Plant Extracts; D013449:Sulfonamides; C010070:cernilton; D000077409:Tamsulosin