title: Prevalence of 52-kd and 60-kd Ro/SS-A autoantibodies in Japanese patients with polymyositis/dermatomyositis.
abstract: To determine the prevalence of 52-kd and 60-kd Ro/SS-A antibodies in Japanese patients with polymyositis/dermatomyositis, we examined serum samples from 61 patients with PM/DM, 10 patients with primary Sjögren's syndrome, and 25 healthy control subjects. Six serum samples possessed anti-Ro/SS-A antibodies and were positive for anti-Ro52, anti-Ro60, or both. Two reacted with both Ro52 and Ro60, and 4 reacted with Ro52 alone. The results suggest that Ro52 is the main antigen of anti-Ro/SS-A antibodies in patients with polymyositis/dermatomyositis and that its coexistence with other defined antibodies suggests the existence of a subgroup of patients with various serologic abnormalities.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Kubo
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ihn
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamane
authors.forename: Norihito
authors.initials: N
authors.lastname: Yazawa
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000235:genetics; D000957:Antigens, Viral, Tumor / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D002648:Child; D003882:Dermatomyositis / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000235:genetics*; D015995:Prevalence; D011336:Probability; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
chemical_list: D000974:Antibodies, Antinuclear; D000957:Antigens, Viral, Tumor; D001323:Autoantibodies; D005819:Genetic Markers; C035356:SS-A antibodies; C040612:glycoprotein 52 antigen, Mouse mammary tumor virus