The Pco proteins are involved in periplasmic copper handling in Escherichia coli.
The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone.
Lee
Sun Mi
SM
Department of Soil, Water, and Environmental Science, University of Arizona, Tucson 85721, USA.
Grass
Gregor
G
Rensing
Christopher
C
Barrett
Siobhán R
SR
Yates
Christopher J D
CJ
Stoyanov
Jivko V
JV
Brown
Nigel L
NL
D001665:Binding Sites; D001692:Biological Transport; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000502:physiology*; D007477:Ions; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D016296:Mutagenesis; D010088:Oxidoreductases / Q000502:physiology; D019897:Periplasm / Q000378:metabolism; D010957:Plasmids / Q000378:metabolism
D029968:Escherichia coli Proteins; D007477:Ions; C462540:PcoA protein, E coli; C462541:PcoC protein, E coli; C462542:PcoE protein, E coli; D003300:Copper; D004247:DNA; D010088:Oxidoreductases; C499679:cueO protein, E coli