title: [Childhood toxoplasmosis today].
abstract: The comparative study of two groups of children suffering from acquired or congenital toxoplasmosis, being in hospital during two different decades (1979-1985--39 children and 1991-1997--117 children) proved: the fact that atypical or subclinical manifestations of the acquired toxoplasmosis (54%) draws our attention to the systematic research of the infection with Toxoplasma gondii, especially at the groups with increased risk now that the frequency of the diseases generating immunodeficiency; the increased frequency of congenital toxoplasmosis (5% in the first group, 8% in the second group) and especially of the invalidating of screening tests to the pregnant women; the therapeutic arsenal limited by the rate price/toxicity/medical resistance, must be individualized for each case, taking into account the increased number of other associated diseases (chronic hepatitis B 7%, TB 17%, HIV infection 5%); Rovamicine treatment at the second group had similar results to those obtained by administrating Pirimetamine--Trimetoprim to the children from the first group.
authors.affiliation: Facultatea de Medicină Clinica a II a Pediatrie, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
authors.forename: S
authors.initials: S
authors.lastname: Goţia
authors.forename: A
authors.initials: A
authors.lastname: Murgu
authors.forename: C
authors.initials: C
authors.lastname: Ailioaic
authors.forename: A
authors.initials: A
authors.lastname: Rugină
authors.forename: L
authors.initials: L
authors.lastname: Brădăţan
authors.forename: R
authors.initials: R
authors.lastname: Russu
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D002981:Clindamycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D015572:Spiramycin / Q000008:administration & dosage; D014122:Toxoplasma / Q000302:isolation & purification*; D014123:Toxoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D002981:Clindamycin; D015572:Spiramycin