title: Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase I.
abstract: BACKGROUND
  Presented here is phase I of a three-part study of non-ablative cutaneous remodeling with a 1.45 microm diode laser configured with a cryogen spray cooling device.
  
  
  METHODS
  Eight men and two women (average age of 67 years) with Fitzpatrick skin phototypes I-IV were treated at postauricular sites. Treatment consisted of one or two passes with a 4mm spot and an average power of 12 W. Heating times ranged from 150 ms to 500 ms applied over two to six treatment cycles. One treatment 'cycle' lasted for 100 ms and consisted of programmable parallel cryogen spray cooling pulses interspersed with unopposed heating. Biopsies were obtained at baseline, immediately after treatment, and at 2 months.
  
  
  RESULTS
  Patients were assessed 1 day, 1 week, 1 month and 2 months after treatment. Treatments were well tolerated with minimal pain, with a trend towards increasing discomfort with longer heating times. Erythema and edema were also mild and short-lived. There was a direct relationship between the degree of erythema and edema, and longer unopposed heating times. Mild hyperpigmentation occurred at only three treatment sites. Epidermal burns usually presented as immediate whitening in 11 of 60 one-pass sites and four of 16 two-pass sites. Whitening was associated with longer unopposed heating times. Atrophic, pitted scars occurred at two single-pass sites and three double-pass sites. Baseline biopsies demonstrated solar elastosis in a 375 microm thick band (mean range from 100 microm to 480 microm deep in the dermis). Immediate post-treatment biopsies demonstrated thermal damage in a 333 microm thick band (mean range from 311 microm to 644 microm deep in the dermis). Finally, dermal fibrosis was observed 2 months after treatment in a 272 microm thick band (mean range from 148 microm to 420 microm deep in the dermis).
  
  
  CONCLUSIONS
  The 1.45 microm diode laser is capable of targeting dermal collagen and stimulating fibrosis at depths where solar elastosis resides. Longer unopposed heating times corresponded to increased erythema, edema, and pain, which were typically mild and short-lived. Epidermal burns can result in pitted scars.
authors.affiliation: Department of Dermatology, Naval Medical Center San Diego, San Diego, CA 92134, USA.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Hardaway
authors.forename: E Victor
authors.initials: EV
authors.lastname: Ross
authors.forename: David J
authors.initials: DJ
authors.lastname: Barnette
authors.forename: Dilip Y
authors.initials: DY
authors.lastname: Paithankar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062109:Dermatologic Surgical Procedures; D004890:Erythema / Q000209:etiology; D005260:Female; D005355:Fibrosis; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012867:Skin / Q000473:pathology; D015595:Skin Aging; D013696:Temperature