title: Antiestrogenic regulation of transforming growth factor beta receptors I and II in human breast cancer cells.
abstract: To obtain more information about the interactions between antiestrogens and transforming growth factor beta (TGF-beta) signaling, we analyzed the influence of different types of antiestrogens on the expression of TGF-beta receptors I (TbetaRI) and II (TbetaRII). Our results show that antiestrogens selectively induce TbetaRII but not TbetaRI mRNA.
authors.affiliation: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and Robert Bosch Hospital, Department of Clinical Chemistry, 70376 Stuttgart, Germany. mariam.buck@ikp-stuttgart.de
authors.forename: M
authors.initials: M
authors.lastname: Buck
authors.forename: J
authors.initials: J
authors.lastname: von der Fecht
authors.forename: C
authors.initials: C
authors.lastname: Knabbe
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D006801:Humans; D017346:Protein Serine-Threonine Kinases; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
chemical_list: D020847:Estrogen Receptor Modulators; D012333:RNA, Messenger; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II