[Comparison of linezolid and vancomycin in nosocomial pneumonia: results of the multicenter double-blind study].
The results of multicenter, randomized, double-blind comparative study of linezolid and vancomycin efficacy, safety and tolerability in the treatment of nosocomial pneumonia are presented. The trial was performed on 69 patients. Clinical efficacy of linezolid was 83 per cent, of vancomycin--79 per cent. Bacteriological effect (pathogen eradication) was 83 per cent for linezolid group and 86 per cent for vancomycin group. During the study good clinical tolerability of linezolid was demonstrated along with lower side effects incidence and shortened recovery period when compared to vancomycin.
Grudinina
S A
SA
National Research Centre of Antibiotics, Municipal Clinical Hospital No. 61.
Zubkov
M M
MM
Krotova
L A
LA
Kurdiukova
Iu P
IuP
Kutsenko
M A
MA
Marinin
V F
VF
Sidorenko
S V
SV
Sinpal'nikov
A I
AI
Solomatin
A S
AS
Sterkhova
G V
GV
Fesenko
O V
OV
Fomina
I G
IG
Chuchalin
A G
AG
D000081:Acetamides / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects / Q000627:therapeutic use*; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000382:microbiology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid