title: [Role of physico-chemical and biochemical composition of urine in the genesis of combined nephrolithiasis and cholelithiasis].
abstract: Enzymuria, principal fractions of phospholipids, crystal-inhibiting urine activity were measured in 120 patients with nephrolithiasis combined with cholelithiasis. The patients were divided into two groups: group 1-80 patients with symptoms of nephrolithiasis and latent cholelithiasis; group 2-40 patients with symptoms of cholelithiasis and latent nephrolithiasis. It is shown that hyperenzymuria/microproteinuria, high excretion of phospholipids and cholesterol with urine in patients with nephrolithiasis and its complications not only affect physico-chemical properties of urine promoting atypical salt crystallization with stone formation but also determine characteristics of phasic urine conditions. High urine concentration of phospholipid (acyl derivatives) degradation products and cholesterol in patients with combination of nephrolithiasis with cholelithiasis changes solubilizing and micello-forming ability of urine and can directly stimulate crystal formation and development of aseptic inflammation in renal parenchyma. Low total crystal-inhibiting urine activity, altered surface-free energy due to surface-active substances, high calcium ionization and low urine magnesium ionization are not only pathognomonic criteria of nephrolithiasis but also parameters reflecting high risk of oxalate-calcium formation in patients with nephrolithiasis combination with cholelithiasis.
authors.forename: A I
authors.initials: AI
authors.lastname: Neĭmark
authors.forename: A V
authors.initials: AV
authors.lastname: Fidirkin
authors.forename: V I
authors.initials: VI
authors.lastname: Savenko
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000652:urine; D002769:Cholelithiasis / Q000150:complications / Q000652:urine*; D002784:Cholesterol / Q000652:urine; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000150:complications / Q000652:urine*; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000652:urine; D016482:Urinalysis
chemical_list: D010743:Phospholipids; D002784:Cholesterol; D008274:Magnesium; D002118:Calcium