Viral RNA-polymerases -- a predicted 2'-O-ribose methyltransferase domain shared by all Mononegavirales.
The Mononegavirales virus group comprises several major human pathogens, including measles, rabies and Ebola viruses. This article reports a computational analysis of the C-terminal region of RNA-dependent RNA-polymerases from Mononegavirales. Using a combination of sequence similarity and threading analysis, a 2'-O-ribose methyltransferase domain was identified that is involved in the capping of viral mRNAs.
Ferron
François
F
Architecture et Fonction des Macromolécules Biologiques, UMR 6098, CNRS, and Universitées Aix-Marseille I and II, ESIL, 163, Avenue de Luminy, Case 925, F-13288 Marseille Cedex 9, France.
Longhi
Sonia
S
Henrissat
Bernard
B
Canard
Bruno
B
D000595:Amino Acid Sequence; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008780:Methyltransferases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D018096:Mononegavirales / Q000201:enzymology* / Q000235:genetics; D017434:Protein Structure, Tertiary; D012315:RNA Caps / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012367:RNA, Viral / Q000378:metabolism; D016415:Sequence Alignment
D012315:RNA Caps; D012367:RNA, Viral; D008780:Methyltransferases; D012321:DNA-Directed RNA Polymerases