title: Quantification of regional right and left ventricular function by ultrasonic strain rate and strain indexes after surgical repair of tetralogy of Fallot.
abstract: The quantification of regional myocardial function in tetralogy of Fallot (TOF) by conventional M-mode and 2-dimensional echocardiography is difficult because of the complex right ventricular (RV) and altered left ventricular (LV) geometry. In 30 asymptomatic postoperative TOF patients (aged 4 to 16 years) with a low pressure in the right ventricle and with varying degrees of pulmonary regurgitation and in 30 aged-matched healthy children, the ultrasonic-derived regional deformation parameters peak systolic strain rate (SR) and systolic strain (epsilon) were acquired from ventricles and compared. In TOF RV free walls, SR, and epsilon were reduced in the basal, mid-, and apical segments and averaged -1.5 +/- 0.6 second(-1) for SR and -22 +/- 8% for epsilon, respectively (p <0.001 vs normals). Peak systolic SR of the basal RV free wall correlated significantly with the QRS duration of the electrocardiogram (r = 0.81, p <0.0001). Abnormalities in RV deformation were more marked in patients with transannular patches versus infundibular patches. In the septum there was a homogeneous reduction in SR and epsilon in the basal, mid-, and apical segments. These averaged -1.4 +/- 0.3 second(-1) for SR and -19 +/- 4% for epsilon, respectively (p <0.01 vs normals). Longitudinal SR and epsilon values of the 3 LV lateral wall segments (averaged SR = -1.6 +/- 0.4 second(-1), averaged epsilon = -20 +/- 5%; p <0.05 vs normals), and radial SR and epsilon of the LV posterior wall (SR = 3.3 +/- 0.9 second(-1); epsilon = 51 +/- 14%; p <0.05 vs normals) were significantly reduced. Thus, abnormalities in regional RV and LV systolic myocardial function in asymptomatic postoperative TOF patients were quantified by the deformation parameters SR and epsilon. RV deformation abnormalities are associated with electrical depolarization abnormalities.
authors.affiliation: Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Weidemann
authors.forename: Benedicte
authors.initials: B
authors.lastname: Eyskens
authors.forename: Luc
authors.initials: L
authors.lastname: Mertens
authors.forename: Christoph
authors.initials: C
authors.lastname: Dommke
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Kowalski
authors.forename: Lisa
authors.initials: L
authors.lastname: Simmons
authors.forename: Piet
authors.initials: P
authors.lastname: Claus
authors.forename: Bart
authors.initials: B
authors.lastname: Bijnens
authors.forename: Marc
authors.initials: M
authors.lastname: Gewillig
authors.forename: Liv
authors.initials: L
authors.lastname: Hatle
authors.forename: George R
authors.initials: GR
authors.lastname: Sutherland
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography / Q000379:methods*; D018618:Echocardiography, Doppler, Color / Q000379:methods; D004562:Electrocardiography; D006801:Humans; D012016:Reference Values; D013599:Systole / Q000502:physiology; D013771:Tetralogy of Fallot / Q000150:complications / Q000601:surgery*; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology