Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism.
Excess body weight and/or lack of physical activity are increasingly recognized as major risk factors for cancer of the colon, breast, endometrium, and prostate. This paper reviews the effects of excess body weight and physical inactivity on endogenous hormone metabolism (insulin, the IGF-I/IGFBP system, and sex steroids) and of endocrine alterations with risk of cancer of the endometrium, breast, prostate, and colon.
Kaaks
Rudolf
R
International Agency for Research on Cancer, 69372 Lyon Cedex 08, France. kaaks@iarc.fr
Lukanova
Annekatrin
A
D001835:Body Weight / Q000502:physiology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000517:prevention & control; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000517:prevention & control; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000517:prevention & control; D015444:Exercise / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*; D009765:Obesity / Q000150:complications / Q000378:metabolism; D011315:Preventive Medicine; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000517:prevention & control; D012307:Risk Factors
D012739:Gonadal Steroid Hormones; D006728:Hormones