[A case of advanced colon cancer with para-aortic lymph node metastasis responding greatly to treatment by adjuvant chemotherapy of low-dose CPT-11 on an outpatient basis].
We administered an adjuvant chemotherapy of a bi-weekly low-dose CPT-11 + 5-FU on an outpatient basis to a patient with advanced sigmoid colon cancer and para-aortic lymph node metastasis. After 3 months, tumor markers fell to normal levels and the regression rate in the lymph node was over 80%. Throughout the period of treatment, there were no side effects, and there was no sign of recurrence for 6 months. In conclusion, we consider that with low-dose CPT-11 + 5-FU chemotherapy on an outpatient basis, the patient can maintain a high quality of life and show a massive effect, and that this regimen can be used as a first-line chemotherapy for advanced colon cancer.
Kawasaki
Masayasu
M
Dept. of Surgery I, Shiga Medical University.
Fujita
Masutsugu
M
Shibata
Junsuke
J
Tani
Tohru
T
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage* / Q000031:analogs & derivatives; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D005472:Fluorouracil; D002166:Camptothecin