[Can urinary corpuscular volume using automated hematology contribute the diagnostic etiology of hematuric microscopy?].
OBJECTIVE
To assess the value of measuring urinary corpuscular volume (UCV) with a haematology automat for determination of the glomerular or non-glomerular origin of isolated microscopic haematuria (MHi).


METHODS
Forty-five fresh urine samples taken from 45 consecutive patients, with a median age of 59 years, consultant for MHi on urinary dip-sticks were studied with a haematology automat. After each analysis, MHi was classified into one of the following three groups: High MHi (glomerular, UCV < 50 fl), low MHi (non-glomerular, UCV > 50 fl), MHi of unknown origin (mixed UCV). A complete aetiological assessment of MHi was performed in each case.


RESULTS
The aetiological diagnosis of MHi was established in 28 cases (62%), with a glomerular origin in 16 cases and a non-glomerular origin in 12 cases. UCV was of the glomerular (19 cases), non-glomerular (3 cases) or mixed type (6 cases). When UCV indicated a glomerular or non-glomerular origin for MHi (22/28 = 78.6%), the result was exact in 77% of cases (17/22). The sensitivity to diagnose glomerular haematuria was 100%, the specificity was 37.5%, the PPV was 73.7% and the NPV waas 100%.


CONCLUSIONS
The study of UCV can suggest the origin of MHi, but cannot confirm this origin due to its poor specificity.
Gamé
Xavier
X
Service d'Urologie et d'Andrologie, CHU Rangueil, 31403 Toulouse, France. xaviergame@hotmail.com
Soulié
Michel
M
Fontanilles
Anne-Marie
AM
Benoit
Jean-Michel
JM
Corberand
Joël-Xavier
JX
Plante
Pierre
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001331:Automation; D003928:Diabetic Nephropathies / Q000175:diagnosis; D004909:Erythrocyte Indices; D005260:Female; D006405:Hematology / Q000379:methods; D006417:Hematuria / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis; D011934:Reagent Strips; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis
D011934:Reagent Strips