[In vitro sensitivity of Plasmodium falciparum to chloroquine, piperaquine, pyronaridine and artesunate in Yuxi prefecture of Yunnan province].
OBJECTIVE
To assess the sensitivity of Plasmodium falciparum to four antimalarials.


METHODS
WHO standard in vitro microtest was used.


RESULTS
The resistance rates of the malaria parasite to chloroquine, piperaquine pyronaridine and artesunate were 85.7%, 66.7%, 38.1% and 5.0%, respectively.


CONCLUSIONS
Among the antimalarials tested in Yuxi Prefecture, Yunnan Province, high resistance of P. falciparum to chloroquine and piperaquine was found. The sensitivity of P. falciparum in part of the cases to pyronaridine decreased. However, most of the cases were relatively sensitive to artesunate.
Fan
B
B
Yuxi City Health and Antiepidemic Station, Yuxi 653100.
Zhao
W
W
Ma
X
X
Huang
Z
Z
Wen
Y
Y
Yang
J
J
Yang
Z
Z
D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D000077332:Artesunate; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D011804:Quinolines / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology; D010879:Piperazines
D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate; D002738:Chloroquine; D009287:Naphthyridines; D011804:Quinolines; D012717:Sesquiterpenes; C034759:piperaquine; D010879:Piperazines; C027871:pyronaridine