title: Does glutamate image your thoughts?
abstract: Functional imaging methods exploit the relationship between neuronal activity, energy demand and cerebral blood flow to functionally map the brain. Despite the increasing use of these imaging tools in basic and clinical neuroscience, the neurobiological processes underlying the imaging signals remain unclear. Recently, interest has been focused on uncovering the signals that trigger the metabolic and vascular changes accompanying variations in neuronal activity. Advances in this field have demonstrated that release of the major excitatory neurotransmitter glutamate initiates diverse signaling processes between neurons and astrocytes, and that this signaling could be crucial for the occurrence of brain imaging signals. In this article we review the hypothesis that glutamate represents a common trigger for both neurometabolic and neurovascular coupling.
authors.affiliation: CEA CNRS URA 2210, Service Hospitalier Frédéric Joliot 4, place du Général Leclerc, 91401 Orsay Cedex, France. bonvento@shjf.cea.fr
authors.forename: Gilles
authors.initials: G
authors.lastname: Bonvento
authors.forename: Nicola
authors.initials: N
authors.lastname: Sibson
authors.forename: Luc
authors.initials: L
authors.lastname: Pellerin
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*; D014055:Tomography, Emission-Computed
chemical_list: D018698:Glutamic Acid