Toll receptors, CD14, and macrophage activation and deactivation by LPS.
This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed.
Dobrovolskaia
Marina A
MA
Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Vogel
Stefanie N
SN
D000818:Animals; D001419:Bacteria / Q000276:immunology*; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018950:Lipopolysaccharide Receptors / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D012772:Shock, Septic / Q000276:immunology / Q000503:physiopathology; D015398:Signal Transduction; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors