title: High-frequency oscillatory ventilation in experimental lung injury: effects on gas exchange.
abstract: OBJECTIVE
  To compare ventilation-perfusion (V(A)/Q) distributions during improvement of oxygenation caused by high-frequency oscillatory ventilation (HFOV) and pressure-controlled mechanical ventilation with high PEEP levels (CMV) in experimental acute lung injury (ALI).
  
  
  METHODS
  Prospective, controlled animal study.
  
  
  METHODS
  Animal research facility of a university hospital.
  
  
  METHODS
  Twelve pigs with oleic acid-induced ALI were randomised to HFOV ( n=6) or to CMV ( n=6) with a PEEP of 15 mbar for 1 h. The mean airway pressure was adjusted in both groups to achieve comparable improvements in arterial oxygen partial pressure (PaO(2)) and to avoid clinically relevant impairments of cardiac output, as assured by adequate mixed venous oxygen saturation and lactate levels. V(A)/Q distributions were determined by the multiple inert gas elimination technique (MIGET).
  
  
  RESULTS
  Arterial oxygen partial pressure improved during CMV with a mean airway pressure of 20 mbar ( p<0.05) whereas HFOV revealed comparable improvements with a mean airway pressure of 40 mbar ( p<0.05). Shunt decreased and blood flow to normal V(A)/Q areas increased due to CMV and HFOV ( p<0.05). The perfusion of low V(A)/Q areas remained unchanged. Statistical analysis did not reveal differences of PaO(2), shunt or blood flow to low V(A)/Q areas between the groups.
  
  
  CONCLUSIONS
  In this model of acute lung injury CMV and HFOV improved gas exchange due to similar changes in V(A)/Q distribution. However, mean airway pressure had to be adjusted twofold higher during HFOV then during CMV to achieve comparable improvements in gas exchange.
authors.affiliation: Klinik fuer Anaesthesiologie, Universitaetsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. Rolf.Dembinski@post.rwth-aachen.de
authors.forename: Rolf
authors.initials: R
authors.lastname: Dembinski
authors.forename: Martin
authors.initials: M
authors.lastname: Max
authors.forename: Ralf
authors.initials: R
authors.lastname: Bensberg
authors.forename: Johannes
authors.initials: J
authors.lastname: Bickenbach
authors.forename: Ralf
authors.initials: R
authors.lastname: Kuhlen
authors.forename: Rolf
authors.initials: R
authors.lastname: Rossaint
mesh_terms: D000818:Animals; D005260:Female; D006439:Hemodynamics; D006612:High-Frequency Ventilation; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000628:therapy*; D013552:Swine