Influence of antimalarial treatment on acquisition of immunity in Plasmodium berghei NK65 malaria.
Antimalarial treatments during primary Plasmodium berghei NK65 infection in BALB/c mice influenced the acquisition of protective immunity against reinfection. Among subcurative treatments, lower doses better enable mice to acquire protective immunity than do higher doses. Eradication of parasites from the start of infection did not promote protective immunity.
Long
Ton That Ai
TT
Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Nakazawa
Shusuke
S
Huaman
Maria Cecilia
MC
Kanbara
Hiroji
H
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007109:Immunity / Q000187:drug effects*; D008288:Malaria / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D018512:Parasitemia / Q000276:immunology; D010962:Plasmodium berghei / Q000254:growth & development
D000962:Antimalarials