Adenomatous polyposis coli gene as a gatekeeper.
The Adenomatous Polyposis Coli (APC) Gene is a tumor suppressor gene located in the chromosome 5q21. It has a sequence of 2843 amino acids and a weight of 312 kD. The mutation of the APC gene occurs at the early stages of most sporadic colorectal cancers; and up to 30% in familial adenomatous polyposis. The absence of APC will indicate the inadequate migration of colon mucous cells and its accumulation resulting in polyps formation, which determines a stage in carcinogenicity. An adequate study in prone groups may lead to chemoprophylaxis and/or early treatment of polyps.
Nakayama
Takamori
T
Department of Surgery, Shizuoka Red Cross Hospital, Shizuoka-shi, Japan.
Morishita
Tetsuo
T
Kamiya
Toshiaki
T
D011125:Adenomatous Polyposis Coli / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D025601:Adenomatous Polyposis Coli Protein / Q000737:chemistry / Q000502:physiology*; D019943:Amino Acid Substitution; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D003598:Cytoskeletal Proteins / Q000502:physiology; D005061:Europe, Eastern / Q000208:ethnology; D005260:Female; D017491:Genes, APC; D006801:Humans; D007585:Jews / Q000235:genetics; D008297:Male; D020125:Mutation, Missense; D009386:Neoplastic Syndromes, Hereditary / Q000453:epidemiology / Q000235:genetics; D017354:Point Mutation; D017384:Sequence Deletion; D015534:Trans-Activators / Q000502:physiology; D051176:beta Catenin
D025601:Adenomatous Polyposis Coli Protein; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016588:Anticarcinogenic Agents; C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin; D001241:Aspirin