[Effects of apoptosis of synovial lining cells on pathogenesis of osteoarthropathy].
The author counted synovial lining cells(SLCs) of apoptosis in the joints of osteoarthropathy(OA, 12 cases) and control(10 cases) patients. The counts of apoptotic SLC were investigated by gel electrophoretic analysis of DNA extracted from synovium. The apoptotic index(AI) of SLCs in OA(2.04%) was obviously higher than that in controls(0.60%); electrophorectogram of DNA revealed a characteristic ladder pattern of DNA fragments at 200 bp in the OA group. We conclude that apoptosis can be found in synovial lining layer, and the AI of SLCs in the OA group is much higher than that in the control group, implying the high turn-over rate of SLCs in OA; the increasing apoptosis of SLCs may increase lesion factors retained in joints and cause the injury of articular cartilage.
Qiu
X
X
Department of Sports Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Zhou
J
J
D017209:Apoptosis; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000473:pathology*; D007719:Knee Joint / Q000473:pathology; D008297:Male; D010003:Osteoarthritis / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology*