title: Analytical methods for the monitoring of solid phase organic synthesis.
abstract: Solid phase synthesis (SPS) is a powerful technique to assemble compound libraries in high-throughput parallel and combinatorial synthesis. The widespread applications of these techniques required the development of analytical methods for both structural elucidation and reaction monitoring. This review covers some recently developed techniques for on-bead analyses together with solution-state ones. Particular emphasis is devoted to software and hardware improvements for automated high-throughput analysis.
authors.affiliation: Computational, Analytical and Structural Sciences, GlaxoSmithKline Medicines Research Center, Verona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dal Cin
authors.forename: S
authors.initials: S
authors.lastname: Davalli
authors.forename: C
authors.initials: C
authors.lastname: Marchioro
authors.forename: M
authors.initials: M
authors.lastname: Passarini
authors.forename: O
authors.initials: O
authors.lastname: Perini
authors.forename: S
authors.initials: S
authors.lastname: Provera
authors.forename: A
authors.initials: A
authors.lastname: Zaramella
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002625:Chemistry, Organic / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D019151:Peptide Library
chemical_list: D019151:Peptide Library