Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family.
A novel Conus peptide, conophysin-R, was purified from the venom of Conus radiatus. The distinctive disulfide framework and sequence indicates that it is a member of the neurophysin peptide family. The complete sequence of the peptide is HPTKPCMYCSFGQCVGPHICCGPTGCEMGTAEANMCSEEDEDPIPCQVFGSDCALNNPDNIHGHCVADGICCVDDTCTTHLGCLThis is the first time a neurophysin-like peptide has been found in any venom. In addition, conophysin-R is the first neurophysin family member isolated and biochemically characterized from an invertebrate source.
Lirazan
M
M
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City 84112-0840, USA.
Jimenez
E C
EC
Grey Craig
A
A
Olivera
B M
BM
Cruz
L J
LJ
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008969:Molecular Sequence Data; D008974:Mollusca / Q000502:physiology*; D008978:Mollusk Venoms / Q000737:chemistry*; D009481:Neurophysins / Q000737:chemistry*; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid; D021241:Spectrometry, Mass, Electrospray Ionization
D008978:Mollusk Venoms; D009481:Neurophysins; C470870:conophysin-R, Conus radiatus