Low expression of DNA polymerase beta in human testicular germ cell tumours--impact on foetal gonocytic origin theory.
Different models of pathogenesis of adult testicular germ cell tumours (TGCTs) are presented. Analysis of telomeric length and DNA polymerase beta expression suggests that seminoma and nonseminoma, two main histological types of TGCTs, derive independently from transformed foetal primordial cells.
Nowak
Radosława
R
Department of Molecular Biology, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland. radka@coi.waw.pl
Grzybowska
Ewa A
EA
Wilczyńska
Anna
A
Pykało
Roman
R
Siedlecki
Janusz A
JA
D015152:Blotting, Northern; D019951:DNA Polymerase beta / Q000378:metabolism*; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology*; D018237:Germinoma / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D013090:Spermatocytes / Q000201:enzymology / Q000473:pathology; D013091:Spermatogenesis; D016615:Telomere / Q000378:metabolism; D013736:Testicular Neoplasms / Q000201:enzymology* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016159:Tumor Suppressor Protein p53; D019951:DNA Polymerase beta