title: "Misura" project: a retrospective survey on the use of 5fluorouracil in the treatment of colorectal cancer in 24 Italian clinical centers.
abstract: The "Misura" project is a retrospective survey, with the aim to evaluate how 5FU is used in the treatment of colorectal cancer in clinical practice in Italian oncology departments. Twenty-four centers participated. Patients seen in the second half of 1998 with colorectal cancer and treated with 5FU were analyzed. Observed patients were 664, 45.9% of patients presented metastatic disease. Biochemical modulation with folinic acid and bolus 5FU was the most used schedule (59%). The De Gramont (LV 5FU2) regimen, alone or with other cytotoxic drugs, was the second most chosen schedule (14%). The most frequent side effect observed was gastrointestinal toxicity. No hematological toxicity was demonstrated in 68.8% of patients. Cutaneous toxicity occurred in 21.1% of patients. 5FU is widely used independently by the stage of disease. In palliative treatment a variety of schedules were administered by the Italian centers, lacking a standard therapy. There are very few surveys investigating oncology clinical practice. A larger survey on this issue is auspicable.
authors.affiliation: Unità Operativa di Oncologia Medica, Ospedali Riuniti, Bergamo, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Poletti
authors.forename: Graziella
authors.initials: G
authors.lastname: Pinotti
authors.forename: Gerardo
authors.initials: G
authors.lastname: Rosati
authors.forename: Gabriele
authors.initials: G
authors.lastname: Luppi
authors.forename: Toni
authors.initials: T
authors.lastname: Ibrahim
authors.forename: Claudio
authors.initials: C
authors.lastname: Marinozzi
authors.forename: Francesca
authors.initials: F
authors.lastname: Pucci
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Pancera
authors.forename: Guido
authors.initials: G
authors.lastname: Biasco
authors.forename: Sandro
authors.initials: S
authors.lastname: Barni
authors.forename: Carlo
authors.initials: C
authors.lastname: Garufi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Martignoni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Visonà
authors.forename: Roberto
authors.initials: R
authors.lastname: Labianca
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002173:Cancer Care Facilities; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D019538:Health Care Surveys; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D012189:Retrospective Studies
chemical_list: D000964:Antimetabolites, Antineoplastic; D002955:Leucovorin; D005472:Fluorouracil