Asymmetric hydrogenation of dehydrodipeptides bearing different protecting groups.
N-[(Z)-N-Benzoyl- or N-boc-(2-fluorophenyl)dehydroalanyl]-(R)- or (S)-phenyl-alanines 1,2,5 and 6 were hydrogenated in the presence of chiral and achiral rhodium complexes. The optical induction is compared to the results obtained using the corresponding esters as substrates.
Döbler
Christian
C
Institut für Organische Katalyseforschung, Universität Rostock e.V., Buchbinderstrasse 5-6, D-18055 Rostock, Germany. christian.doebler@ifok.uni-rostock.de
Kreuzfeld
H-J
HJ
Fischer
Chr
C
Michalik
M
M
D004151:Dipeptides / Q000737:chemistry*; D006865:Hydrogenation
D004151:Dipeptides