title: Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family.
abstract: A novel Conus peptide, conophysin-R, was purified from the venom of Conus radiatus. The distinctive disulfide framework and sequence indicates that it is a member of the neurophysin peptide family. The complete sequence of the peptide is HPTKPCMYCSFGQCVGPHICCGPTGCEMGTAEANMCSEEDEDPIPCQVFGSDCALNNPDNIHGHCVADGICCVDDTCTTHLGCLThis is the first time a neurophysin-like peptide has been found in any venom. In addition, conophysin-R is the first neurophysin family member isolated and biochemically characterized from an invertebrate source.
authors.affiliation: Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City 84112-0840, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lirazan
authors.forename: E C
authors.initials: EC
authors.lastname: Jimenez
authors.forename: A
authors.initials: A
authors.lastname: Grey Craig
authors.forename: B M
authors.initials: BM
authors.lastname: Olivera
authors.forename: L J
authors.initials: LJ
authors.lastname: Cruz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008969:Molecular Sequence Data; D008974:Mollusca / Q000502:physiology*; D008978:Mollusk Venoms / Q000737:chemistry*; D009481:Neurophysins / Q000737:chemistry*; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D008978:Mollusk Venoms; D009481:Neurophysins; C470870:conophysin-R, Conus radiatus