title: The Drosophila Mutant tetanic Interacts with a Gene Complex Including the Structural Locus of K+ Channels and Shows Altered Dephosphorylation and Learning.
abstract: The tetanic (tta; X.-52.6) mutation has been isolated on the basis of its sensitivity to extradoses of the normal Shaker gene complex (ShC) where the K+ channel la is encoded. The mutant shows up to threefold elevation of the membrane bound protein phosphatase type 1 (PP1) activity in body extracts, probably due to reduced levels of the PP1 specific inhibitor 2 (I-2). By contrast, PP1 activity in the head is only half of the normal value. In addition, tta fails to perform normally in a negative reinforcement olfactory paradigm. The functional relationships between phosphorylation, K+ currents, phosphatase activity and modulation of synaptic activity during learning and memory are discussed in the light of their possible genetic links.
authors.affiliation: Neurobiology Department, The Weizmann Institute for Science, Rehovot, Israel.
authors.forename: S.
authors.initials: S
authors.lastname: Orgad
authors.forename: S.
authors.initials: S
authors.lastname: Llamazares
authors.forename: Y.
authors.initials: Y
authors.lastname: Dudai
authors.forename: A.
authors.initials: A
authors.lastname: Ferrús