Is IL12B a potential genetic target for the prevention of type 1 diabetes through dietary intervention?
Type 1 diabetes mellitus (T1D) results from decreased insulin production. Its clinical expression is the result of an array of genetic and environmental factors. The IL12B gene could be one of the loci implicated in the genetic susceptibility of T1D. Thus, this genetic predisposition could be modulated by dietary factors. However, there is no consistency among populations in relation to relevance of this locus as a candidate gene for T1D.
Ordovas
Jose M
JM
USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Qi
Lu
L
Shen
Haiqing
H
Mayer
Jean
J
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D018664:Interleukin-12; D053762:Interleukin-12 Subunit p40; D007378:Interleukins / Q000235:genetics*; D008297:Male; D051379:Mice
C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40; D007378:Interleukins; D018664:Interleukin-12