title: Evaluation of the efficacy of oral lufenuron combined with topical enilconazole for the management of dermatophytosis in catteries.
abstract: The efficacy of oral lufenuron, a chitin synthetase inhibitor, combined with topical enilconazole, was evaluated for the management of Microsporum canis infection in 100 cats housed in two catteries in France. The cats were treated with weekly rinses with enilconazole (0.2 per cent) for four weeks and, in each cattery, one group (A) was also treated with micronised griseofulvin (25 mg/kg administered orally twice a day for five weeks) and a second group (B) was treated with 60 mg/kg lufenuron administered orally once on day 0 and again after 30 days. All the cats were examined individually for cutaneous lesions and mycological cultures were made when the treatment began and after 15, 30, 60 and 90 days. In the first cattery, the cats' clinical scores after 30 and 60 days were significantly lower in group B than in group A. In both catteries and both treatment groups, the mean number of fungal colonies decreased rapidly during the first 15 days of treatment, remained stable for the following 45 days but increased from day 60 to the end of the experiment on day 90.
authors.affiliation: Equipe de Mycologie, UMR 956 INRA-AFSSA-ENVA-Paris XII Biologie Moléculaire et Immunologie Parasitaires et Fongiques, France.
authors.forename: J
authors.initials: J
authors.lastname: Guillot
authors.forename: E
authors.initials: E
authors.lastname: Malandain
authors.forename: F
authors.initials: F
authors.lastname: Jankowski
authors.forename: K
authors.initials: K
authors.lastname: Rojzner
authors.forename: C
authors.initials: C
authors.lastname: Fournier
authors.forename: F
authors.initials: F
authors.lastname: Touati
authors.forename: R
authors.initials: R
authors.lastname: Chermette
authors.forename: W
authors.initials: W
authors.lastname: Seewald
authors.forename: R
authors.initials: R
authors.lastname: Schenker
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003881:Dermatomycoses / Q000188:drug therapy / Q000662:veterinary*; D004359:Drug Therapy, Combination; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008864:Microsporum / Q000302:isolation & purification; D016896:Treatment Outcome; D005466:Fluorocarbons
chemical_list: D000935:Antifungal Agents; D001549:Benzamides; D007093:Imidazoles; C070364:fluphenacur; D005466:Fluorocarbons; C017435:enilconazole