Inhaled diazeniumdiolates (NONOates) as selective pulmonary vasodilators.
Selective pulmonary vasodilators cause vasodilatation limited to the pulmonary vasculature, within well-ventilated lung regions. Selective pulmonary vasodilators ideally cause only a minimal effect on the systemic circulation and improve ventilation/perfusion matching. NONOates are a novel group of chemical compounds that spontaneously and continuously release nitric oxide under physiological conditions, over periods of up to 24 h. Inhaled NONOates retain the benefits of gaseous nitric oxide without many of its therapeutic disadvantages. This review focuses on the therapeutic potential of inhaled NONOates in pulmonary hypertension, other lung conditions associated with right ventricular dysfunction and in asthma. The potential toxicity of NONOates is also discussed.
Lam
Chen-Fuh
CF
Department of Pharmacology, University of Western Australia, Crawley, WA 6009, Australia. cflam@cyllene.uwa.edu.au
Sviri
Sigal
S
Ilett
Kenneth F
KF
van Heerden
Peter V
PV
D000208:Acute Disease; D000280:Administration, Inhalation; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001391:Azo Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy; D009569:Nitric Oxide / Q000502:physiology; D020030:Nitric Oxide Donors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011652:Pulmonary Circulation / Q000187:drug effects*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D001391:Azo Compounds; D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; C452539:diazeniumdiolate; D009569:Nitric Oxide