title: SIADH and hyponatremia with theophylline.
abstract: OBJECTIVE
  To report a case of possible theophylline-induced hyponatremia due to the syndrome of inappropriate antidiuretic hormone (SIADH).
  
  
  METHODS
  An 88-year-old man developed severe symptomatic hyponatremia (serum sodium 112 mEq/L) associated with inappropriate natriuresis (urinary sodium 58 mEq/L) temporally related to the initiation of theophylline. The patient fulfilled the criteria for the diagnosis of SIADH after all other causes of hyponatremia were excluded. Furthermore, no other drugs or conditions that could have evoked SIADH were found.
  
  
  CONCLUSIONS
  Theophylline has rarely been associated with hyponatremia. A thiazide-like action of the drug on the stimulation of SIADH could be the underlying mechanism for SIADH.
  
  
  CONCLUSIONS
  Theophylline should be considered as a possible cause of hyponatremia.
authors.affiliation: Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Evagelos N
authors.initials: EN
authors.lastname: Liberopoulos
authors.forename: George H
authors.initials: GH
authors.lastname: Alexandridis
authors.forename: Dimitris S
authors.initials: DS
authors.lastname: Christidis
authors.forename: Moses S
authors.initials: MS
authors.lastname: Elisaf
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D008297:Male; D013806:Theophylline / Q000009:adverse effects*
chemical_list: D013806:Theophylline