title: [Histiocytic necrotizing lymphadenitis or Kikuchi's disease. CT radiologic features].
abstract: Histiocytic necrotizing lymphadenitis, Kikuchi Fujimoto's disease (KFD) is characterised by fever and lymphadenopathy, usually large cervical, unilateral lymph nodes. Such clinical presentation demands a work-up to exclude serious medical conditions like malignancy and infections. Foci of necrosis with lymphocytic Histiocytic predominance in association with scarce polymorphonuclear cells on lymph node examination, confirm the diagnosis of KFD. Many different patterns of computed tomographic (CT) appearance of KFD have been reported. We describe the CT scan finding in two patients with this disease. All our cases showed, after two and three weeks of evolution respectively, enlarged lymph nodes with hypodense centres and peripheral ring enhancement. These radiological alterations correlated with the central lymph node necrosis found in the anatomopathological studies. In conclusion, KFD should be considered in patients with fever, cervical lymph node enlargement and CT scan showing hypointense centres and peripheral ring enhancement.
authors.affiliation: Unidad de Enfermedades Infecciosas, Complejo Hospitalario Xeral-Cíes, Universidad de Santiago, Vigo.
authors.forename: C
authors.initials: C
authors.lastname: Martínez Vázquez
authors.forename: C
authors.initials: C
authors.lastname: Vilariño
authors.forename: P
authors.initials: P
authors.lastname: Martínez-Cueto
authors.forename: A
authors.initials: A
authors.lastname: López
authors.forename: B
authors.initials: B
authors.lastname: Sopeña
authors.forename: J
authors.initials: J
authors.lastname: de La Fuente
mesh_terms: D000328:Adult; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed