title: Modeling the effect of progressive endotracheal tube occlusion on tidal volume in pressure-control mode.
abstract: A recognized hazard of prolonged endotracheal intubation is progressive airway occlusion resulting from deposition of secretions on the inner surface of the endotracheal tube (ETT). When volume-controlled ventilation is used, progressive ETT occlusion may be detected by monitoring the difference between peak and plateau airway pressures. In pressure-controlled modes, however, inspiratory airway pressures are preset and thus cannot act as a warning indicator. Instead, changes in delivered tidal volumes may aid the diagnosis of ETT occlusion. To determine whether tidal volume monitoring effectively detects progressive ETT occlusion, we mathematically modeled the response of a ventilator operating in pressure-controlled mode to increasing airway resistance. To corroborate our model, we then bench-tested the Siemens 300 and Puritan-Bennett 7200 ventilators by using a test lung and a series of ETTs ranging in size from 9.0 to 3.5 mm inner diameter to simulate progressive occlusion. We found that when pressure-controlled mode was used, progressive ETT occlusion did not reduce delivered tidal volumes until occlusion was nearly complete. We conclude that prolonged use of pressure-controlled mode may allow significant ETT obstruction to build up undetected, risking complete ETT occlusion and complicating the perioperative care of patients ventilated with this mode.
  
  
  CONCLUSIONS
  Although increasing airway pressures during volume-controlled ventilation allow early recognition of endotracheal tube (ETT) obstruction, airway pressures with pressure-controlled ventilation are fixed. We found during tests of two intensive care unit ventilators that although ETT obstruction reduces delivered tidal volumes during pressure-controlled ventilation, reductions do not occur until occlusion is advanced.
authors.affiliation: Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA. atung@airway.uchicago.edu
authors.forename: Avery
authors.initials: A
authors.lastname: Tung
authors.forename: Sherwin E
authors.initials: SE
authors.lastname: Morgan
mesh_terms: D000465:Algorithms; D003422:Critical Care; D006801:Humans; D007442:Intubation, Intratracheal; D008954:Models, Biological; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D013990:Tidal Volume / Q000502:physiology*; D012122:Ventilators, Mechanical