Effect of colestimide on absorption of unconjugated bile acids in the rat jejunum.
BACKGROUND
Colestimide is a newly developed bile acid-binding resin in Japan, but its bile acid-binding properties have not been studied.


METHODS
The absorption of unconjugated bile acids (5 mmol/L) in the ligated rat jejunum was compared in the presence and absence of colestimide. Furthermore, bile acid adsorption by colestimide was also studied in vitro.


RESULTS
All bile acids were efficiently absorbed in the jejunum and the cumulative absorption during 120 min was 29-63%. The absorption of chenodeoxycholate, lithocholate, deoxycholate and ursodeoxycholate was dose-dependently inhibited by 2.5 and 5 mg colestimide, whereas the absorption of cholate was not inhibited, even in the presence of 5 mg colestimide. Adsorption of bile acids by colestimide in vitro was approximately 60% for chenodeoxycholate, lithocholate, deoxycholate and ursodeoxycholate, whereas the adsorption of cholate was low (16%).


CONCLUSIONS
Jejunal absorption of ursodeoxycholate was inhibited by colestimide to a similar extent as other dihydroxy bile acids, whereas that of cholate was not inhibited under the same conditions.
Onishi
Toshiki
T
Department of Medicine, Teikyo University School of Medicine, Kaga 2-11-1, Itabashi-ku, Tokyo 173, Japan.
Sano
Naoyo
N
Takikawa
Hajime
H
D000818:Animals; D000837:Anion Exchange Resins / Q000378:metabolism / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000493:pharmacokinetics; D019826:Cholic Acid / Q000493:pharmacokinetics; D003840:Deoxycholic Acid / Q000493:pharmacokinetics*; D004811:Epichlorohydrin; D007093:Imidazoles; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012117:Resins, Synthetic; D013997:Time Factors
D000837:Anion Exchange Resins; D001647:Bile Acids and Salts; D007093:Imidazoles; D012117:Resins, Synthetic; C417427:colestimide; D003840:Deoxycholic Acid; D004811:Epichlorohydrin; D019826:Cholic Acid