title: An intensive approach to the treatment of disseminated BCG infection in a SCID patient.
abstract: There is an appreciable mortality associated with BMT in patients with SCID and advanced BCG infection. We present a girl with T-B+ SCID complicated by spina ventosa and disseminated BCG osteitis after receiving a fully matched sibling marrow transplant. Considerable progression characterised by two clinical activations and multiple pleural and perivertebral abscess formations occurred with conventional anti-mycobacterial chemotherapy. She finally recovered with full immune reconstitution after BMT and intensive treatment comprising five conventional and alternative agents that she received for 36 months. No side-effects and/or complications have been seen other than hearing loss.
authors.affiliation: Ankara University Medical School, Pediatric Bone Marrow Transplantation Unit, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ikincioğullari
authors.forename: F
authors.initials: F
authors.lastname: Doğu
authors.forename: E
authors.initials: E
authors.lastname: Ciftci
authors.forename: E
authors.initials: E
authors.lastname: Unal
authors.forename: M
authors.initials: M
authors.lastname: Ertem
authors.forename: I
authors.initials: I
authors.lastname: Reisli
authors.forename: S
authors.initials: S
authors.lastname: Adiyaman
authors.forename: S T
authors.initials: ST
authors.lastname: Yildiran
authors.forename: S
authors.initials: S
authors.lastname: Erekul
authors.forename: E
authors.initials: E
authors.lastname: Babacan
mesh_terms: D000904:Antibiotics, Antitubercular / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001500:BCG Vaccine / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D009169:Mycobacterium tuberculosis; D016511:Severe Combined Immunodeficiency / Q000150:complications* / Q000628:therapy; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000904:Antibiotics, Antitubercular; D000970:Antineoplastic Agents; D001500:BCG Vaccine