Alpha1-adrenergic receptors and their significance to chemical-induced nephrotoxicity--a brief review.
Stimulation of alpha-adrenergic receptors by cold stress or adrenergic agents has been shown to potentiate the toxicity of numerous toxicants. Several lines of evidence indicate that this interaction is dependent on glutathione depression and increased cytosolic Ca2+ concentrations produced by alpha1-adrenergic compounds. In this report, evidence is provided in support of the mechanism of adrenoreceptor-mediated potentiation of nephrotoxicity. Alpha1-adrenergic agonists are shown to potentiate the toxicity of nephrotoxicants that exert their toxic effects via glutathione conjugation or Ca2+ deregulation. This review summarizes the effects of the alpha1-adrenergic agonist, phenylephrine, at enhancing the toxicity of 2-bromohydroquinone, 1,2-dibromoethane, and cis-diammineplatinum(II) dichloride.
Stedeford
T
T
Department of Neurology, College of Medicine, University of South Florida, Tampa 33612, USA.
Cardozo-Pelaez
F
F
Vultaggio
B
B
Muro-Cacho
C
C
Luzardo
G E
GE
Harbison
R D
RD
D000818:Animals; D016227:Benzoquinones / Q000819:agonists / Q000378:metabolism / Q000633:toxicity*; D002945:Cisplatin / Q000819:agonists / Q000378:metabolism / Q000633:toxicity*; D004347:Drug Interactions; D015946:Ethylene Dibromide / Q000819:agonists / Q000378:metabolism / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018384:Oxidative Stress / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism
D016227:Benzoquinones; D011942:Receptors, Adrenergic, alpha; D015946:Ethylene Dibromide; D010656:Phenylephrine; C067913:2-bromo-1,4-benzoquinone; D002945:Cisplatin