Paroxetine associated hepatotoxicity: a report of 3 cases and a review of the literature.
We recently encountered 3 patients who had developed reversible paroxetine-associated hepatotoxicity. Two of the patients were over 80 years old and their hepatitis was accompanied by hyponatremia. In the third case, hepatitis was associated with multiple organ failure and the co-administration of trazodone. Here, we will discuss the possible role of preexisting risk factors in the development of paroxetine hepatotoxicity and review the relevant literature.
Azaz-Livshits
T
T
Department of Medicine and Clinical Pharmacology, Hadassah University Hospital, Jerusalem, Israel. azaz@hadassah.org.il
Hershko
A
A
Ben-Chetrit
E
E
D000368:Aged; D000369:Aged, 80 and over; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects*; D012307:Risk Factors
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine