[Study on regulators of the cell cycle in cutaneous squamous cell carcinoma].
In order to investigate the relationship between the regulators of cell cycle and cutaneous squamous cell carcinoma(SCC), we used an immunohistochemical staining technique to examine the expression of cyclin D1, p16 and Rb in the paraffin embedded skin cancer tissues of 30 patients with SCC. The positive percentage of cyclin D1, CDK4, p16 and Rb was 66.7%, 53.3%, 33.3%, and 36.7%, respectively. The overexpression of cyclin D1 and CDK4 could be observed frequently in low grade of differentiated cells, especially in marginal cells of the cancer nest. The results indicate that the aberrant expression of positive and negative regulators of the cell cycle may be involved in the carcinogenesis and evolution of SCC.
Lu
Q
Q
Department of Dermatology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Lu
F
F
Yang
Z
Z
Wen
H
H
Yan
L
L
Chen
S
S
Liu
B A
BA
D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D002453:Cell Cycle; D019938:Cyclin D1 / Q000032:analysis*; D051358:Cyclin-Dependent Kinase 4; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis; D018844:Cyclin-Dependent Kinases / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D011518:Proto-Oncogene Proteins; D012878:Skin Neoplasms / Q000737:chemistry*
D019941:Cyclin-Dependent Kinase Inhibitor p16; D011518:Proto-Oncogene Proteins; D019938:Cyclin D1; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases