title: Properly designed modular asymmetric synthesis for enantiopure sulfinamide auxiliaries from N-sulfonyl-1,2,3-oxathiazolidine-2-oxide agents.
abstract: Simple and practical asymmetric synthesis of functionally differentiated aminoindanol based endo-N-sulfonyl 1,2,3-oxathiazolidine-2-oxide as sulfinyl transfer agents are developed. The importance of these new and unique sulfinyl transfer reagents are exemplified by the expedient production of several sulfinamide ligands, including either enantiomer of (R)-tert-butanesulfinamide in excellent yields and enantiopurities.
authors.affiliation: Chemical Process Research and Development, Sepracor, Inc., 111 Locke Drive, Marlborough, Massachusetts 01752, USA.
authors.forename: Zhengxu
authors.initials: Z
authors.lastname: Han
authors.forename: Dhileepkumar
authors.initials: D
authors.lastname: Krishnamurthy
authors.forename: Paul
authors.initials: P
authors.lastname: Grover
authors.forename: Q Kevin
authors.initials: QK
authors.lastname: Fang
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013441:Sulfinic Acids / Q000138:chemical synthesis*; D013461:Sulfur Oxides / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000577:Amides; D013441:Sulfinic Acids; D013461:Sulfur Oxides; D013844:Thiazoles