[Captopril in the treatment of acute myocardial infarction. Hypotension as an important clinical problem].
The aim of study was to analyze the effect of captopril (C) on blood pressure in patients with acute myocardial infarction (AMI) during 1 year treatment. Patients less then 70 years old with systolic blood pressure (sBP) > or = 100 mm Hg were qualified to the study. Administration of C was started during the first 4 days of AMI (mean 21 +/- 24 h). 50 pts treated with C and control group of 43 pts were finally analyzed. Doses of C were gradually increased from 3.125 t.i.d. on the first day till 25 mg t.i.d. on the 4th day. Significant decrease of sBP after administration of C was observed at 60 and 120 min after the 1st, 2nd and 3rd dose on the first day, and after 30-120 min after first C dose on the 4th day. dBP decreased only at 60-120 min after the 1st dose on first day and at 90 min after the first dose on 4th day. Hypotension after 1st and 2nd dose of C on the first day caused exclusion of 3 pts (6%) from the study. In conclusion, hypotension seems to be quite often encountered during captopril therapy of early phase of AMI. It appears not only after the first but also after the following doses. The initial dose of 3.125 mg seems to be safe and sufficient to assess its hypotensive action.
Wierzchowiecki
Michał
M
II Klinika Kardiologii Instytutu Kardiologii AM w Poznaniu.
Szymanowska
Katarzyna
K
Poprawski
Kajetan
K
Krzyś
Tadeusz
T
Sieńko
Andrzej
A
Michałowicz
Barbara
B
Michalski
Marek
M
Juszczak
Anna
A
D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000453:epidemiology; D011044:Poland / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D002216:Captopril