Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma.
Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.
Giannitrapani
L
L
Istituto di Medicina Interna e Geriatria, Università di Palermo, Palermo, Italy.
Cervello
M
M
Soresi
M
M
Notarbartolo
M
M
La Rosa
M
M
Virruso
L
L
D'Alessandro
N
N
Montalto
G
G
D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology*; D008113:Liver Neoplasms / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000097:blood / Q000276:immunology*
D015850:Interleukin-6; D019947:Receptors, Interleukin-6