title: Differences in mandibular distraction osteogenesis after corticotomy and osteotomy.
abstract: Corticotomy or osteotomy was performed on opposing sides of the mandibles in 18 goats. A custom-made distractor was used to lengthen the mandible at a rate of 1 mm/day for 10 days (total 10 mm elongation). Six goats were sacrificed respectively at 2, 4 and 8 weeks after completion of distraction. The distracted calluses were harvested and processed for radiographic, histologic, and scanning electron microscopic evaluation as well as Ca/P ratio analysis. The regenerate bone in the corticotomy side showed more bone formation and earlier mineralization than in the osteotomy side. The results of this study suggest that preservation of intramedullary vessels is beneficial to bone regeneration following mandibular osteodistraction, and that performing corticotomy may be a simple but effective way to promote the maturity of the distracted callus and shorten the time for fixation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Huaxi School of Stomatology, Sichuan University, Chengdu, China. doctorhu@sc.homeway.com.cn
authors.forename: J
authors.initials: J
authors.lastname: Hu
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: M J
authors.initials: MJ
authors.lastname: Buckley
authors.forename: S
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D002146:Bony Callus / Q000737:chemistry / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D004577:Electron Probe Microanalysis; D006041:Goats; D008297:Male; D008334:Mandible / Q000601:surgery*; D019186:Mandibular Advancement / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D019857:Osteogenesis, Distraction / Q000379:methods*; D010027:Osteotomy; D010521:Periosteum / Q000601:surgery; D010758:Phosphorus / Q000378:metabolism
chemical_list: D010758:Phosphorus; D002118:Calcium