[Antifungal agents can change the balance between resistant and susceptible Candida species].
The use of fluconazole against yeast infections eradicates susceptible but promotes naturally resistant candida strains as C glabrata and C krusei. C albicans dominated in blood cultures taken at the Karolinska Hospital during the years 1989-2001. There was no trend towards an increase of Candida non-albicans. Restrictive use of fluconazole may explain why the balance between different Candida species with varying susceptibility to fluconazole has not shifted.
Petrini
Björn
B
Avdelningen för klinisk mikrobiologi, Karolinska sjukhuset och Karolinska institutet, Stockholm. Bjorn.petrini@ks.se
Chryssanthou
Erja
E
D000935:Antifungal Agents / Q000009:adverse effects*; D002175:Candida / Q000187:drug effects* / Q000276:immunology; D002176:Candida albicans / Q000187:drug effects / Q000276:immunology; D002177:Candidiasis / Q000188:drug therapy; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans
D000935:Antifungal Agents; D015725:Fluconazole