[Nitric oxide formation by chromaffinocytes of respiratory system and its importance for catecholamine exocytosis].
Chromaffinocytes (both single and within paraganglia) located in larynx, trachea, extrapulmonary bronchi and lungs possess NADPH-diaphorase/NO-synthase activity. Chromaffinocytes and paraganglia are anatomically associated with the vagus, autonomous ganglia and the walls of small blood vessels. NO-synthase agonists, acethylcholine and Ca ionophore A23217, after intrapleural injection increase the enzyme activity, that is accompanied with the decrease of luminescence intensity and a reduction of monoamine content in cell cytoplasm. It is concluded that NO is involved in the mechanism of catecholamine release.
Motavkin
P A
PA
Department of Histology, Vladivostok State Medical University.
Andreeva
N A
NA
Eliseeva
E V
EV
D000328:Adult; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D019439:Chromaffin Cells / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D005089:Exocytosis / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010233:Paraganglia, Chromaffin / Q000648:ultrastructure; D051381:Rats; D012137:Respiratory System / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure
D002395:Catecholamines; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase