Polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates.
Two polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates have been developed. p-Hydroxybenzyl alcohol and beta-mercaptoethanol were immobilized on cross-linked divinylbenzene-polystyrene copolymer and conjugated with methyl N,N-diisopropylchlorophosphoramidite. Carbohydrates were reacted with polymer-bound phosphitylating reagents. Further oxidation, with or without the methoxy group deprotection, and cleavage yielded methylphosphorylated or phosphorylated carbohydrates, respectively.
Parang
Keykavous
K
Department of Biomedical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston 02881, USA. kpa0339u@postoffice.uri.edu
D001592:Benzyl Alcohols / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry; D008623:Mercaptoethanol / Q000737:chemistry; D010755:Organophosphates / Q000138:chemical synthesis; D009943:Organophosphorus Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010766:Phosphorylation; D011108:Polymers / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D020058:Styrene / Q000737:chemistry
D001592:Benzyl Alcohols; D002241:Carbohydrates; D006843:Hydrocarbons, Chlorinated; D010755:Organophosphates; D009943:Organophosphorus Compounds; D011108:Polymers; D011137:Polystyrenes; C434331:phosphoramidite; C018966:4-hydroxybenzyl alcohol; D020058:Styrene; D008623:Mercaptoethanol