Induction or inhibition: the complexity of cytochrome P450 enzymes and their impact on drug interactions.
Drug interactions are a major concern for health care professionals, the pharmaceutical manufacturing industry, the FDA, and the general public. Today we know that one of the primary causes of drug interactions is the cytochrome P450 enzymes. However, our knowledge about the complexities of these drug-metabolizing enzymes and the part they play in drug interactions is often limited. The actions and effects of P450 enzymes will be addressed in this article. Examples of induction and inhibition of P450 enzymes will illustrate how these enzymes can, in some instances, render a drug less potent and at other times more toxic. By understanding the unique actions of these enzymes, health care professionals may better anticipate, identify, explain, and manage individual responses to pharmacotherapeutic regimens.
Turkoski
Beatrice B
BB
Kent State University College of Nursing, Kent, Ohio, USA.
D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology*; D004347:Drug Interactions / Q000502:physiology*; D016903:Drug Monitoring / Q000379:methods / Q000451:nursing; D006801:Humans; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology
D003577:Cytochrome P-450 Enzyme System