title: Eph family functions from an evolutionary perspective.
abstract: Eph receptor tyrosine kinases and ephrins have been identified in organisms ranging from sponges to flies and worms to chick, mice and humans, thus allowing their function to be approached also from an evolutionary perspective. The structural analysis of Eph/ephrin crystals is providing hints for the existence of Eph and ephrin folds in plants and suggests a mechanism for triggering bi-directional signalling.
authors.affiliation: MRC Centre for Developmental Neurobiology, King's College London, New Hunt's House, London, UK. uwe.drescher@kcl.ac.uk
authors.forename: Uwe
authors.initials: U
authors.lastname: Drescher
mesh_terms: D000818:Animals; D036342:Ephrins / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D005810:Multigene Family; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D036081:Receptors, Eph Family / Q000235:genetics* / Q000502:physiology; D012160:Retina / Q000502:physiology; D013477:Superior Colliculi / Q000502:physiology
chemical_list: D036342:Ephrins; D036081:Receptors, Eph Family