title: Molecular evolution of proteasomes.
abstract: Proteasomes are large, multisubunit proteases that are found, in one form or another, in all domains of life and play a critical role in intracellular protein degradation. Although they have substantial structural similarity, the proteasomes of bacteria, archaea, and eukaryotes show many differences in architecture and subunit composition. This article discusses possible paths by which proteasomes may have evolved from simple precursors to the highly complicated and diverse complexes observed today.
authors.affiliation: SmithKline Beecham Pharmaceuticals, UP 1345, 1250 South Collegeville Road, Collegeville, PA 19426-0989, USA.
authors.forename: C
authors.initials: C
authors.lastname: Volker
authors.forename: A N
authors.initials: AN
authors.lastname: Lupas
mesh_terms: D000251:Adenosine Triphosphatases / Q000145:classification / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D002451:Cell Compartmentation; D003546:Cysteine Endopeptidases / Q000235:genetics; D010450:Endopeptidases / Q000145:classification / Q000235:genetics; D005057:Eukaryotic Cells / Q000201:enzymology / Q000648:ultrastructure; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics; D010802:Phylogeny; D011387:Prokaryotic Cells / Q000201:enzymology / Q000648:ultrastructure; D046988:Proteasome Endopeptidase Complex
chemical_list: D009097:Multienzyme Complexes; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases