Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica.
The antiviral and antioxidant activity of some fractions and of a series of flavonoids and proanthocyanidins obtained from Crataegus sinaica (Rosaceae) was evaluated. The O-glycosidic flavonoids and the oligomeric proanthocyanidins exhibited significant inhibitory activity against herpes simplex virus type 1 (HSV-1), which was shown to be due to an extracellular mechanism for procyanidin C-1. Procyanidin C-1 also had the highest antioxidant activity in both the microsomal lipid peroxidation and the hydroxyl radical scavenging assay. In addition to the previously reported phenolic compounds, the pentacyclic triterpenoid ursolic acid (1) and a tetrameric (2) and pentameric procyanidin (3) are reported for the first time.
Shahat
Abdelaaty A
AA
Cos
Paul
P
De Bruyne
Tess
T
Apers
Sandra
S
Hammouda
Fayza M
FM
Ismail
Shams I
SI
Azzam
Safa
S
Claeys
Magda
M
Goovaerts
Etienne
E
Pieters
Luc
L
Vanden Berghe
Dirk
D
Vlietinck
Arnold J
AJ
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D044946:Biflavonoids; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002522:Chlorocebus aethiops; D027825:Crataegus; D005419:Flavonoids / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D044945:Proanthocyanidins; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D014709:Vero Cells / Q000187:drug effects / Q000821:virology; D000097245:Ursolic Acid
D000872:Anthocyanins; D000975:Antioxidants; D000998:Antiviral Agents; D044946:Biflavonoids; D002392:Catechin; D005419:Flavonoids; D010936:Plant Extracts; D044945:Proanthocyanidins; D014315:Triterpenes; D000097245:Ursolic Acid; C013221:proanthocyanidin; C479583:procyanidin C; C017674:procyanidin