[Follow-up study of antibodies to nerve growth factor level in children with brain dysgenesis].
A level of antibodies to nerve growth factor (NGF) in blood serum of children with brain dysgenesis has been studied. This level was investigated in follow-up study that allowed to compare it with psychomotor development of the children as well as anatomical brain defect expression (according to MRT and EEG data). Comparing to controls, an increase of antibodies levels in blood serum was found in the patients. No relation of antibodies levels to anatomical brain defect severity was observed. The highest level was shown for the children with the absence of positive dynamics for psychomotor development. In the follow-up study of the children with satisfactory compensation of neurological syndromes, this level decreased to control one. Appearance and elevation of the autoimmune response to NGF can be one of the biological factors, arguing for deterioration of compensatory nervous system potential.
Kliushnik
T P
TP
Ishkhanova
S Iu
SIu
Krasnolobova
S A
SA
Lideman
R R
RR
D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001921:Brain / Q000002:abnormalities* / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009414:Nerve Growth Factors / Q000276:immunology*
D001323:Autoantibodies; D009414:Nerve Growth Factors