Immunological functions of the proteasome.
Proteasomes are highly abundant cytosolic and nuclear protease complexes that degrade most intracellular proteins in higher eukaryotes and appear to play a major role in the cytosolic steps of MHC class I antigen processing. This review summarizes the knowledge of the role of proteasomes in antigen processing and the impact of proteasomal proteolysis on T cell-mediated immunity.
Niedermann
G
G
Max Planck Institute of Immunobiology, Stübeweg 51, 79108 Freiburg, Germany.
D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D003546:Cysteine Endopeptidases / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D010455:Peptides / Q000276:immunology; D046988:Proteasome Endopeptidase Complex; D017634:Self Tolerance
D015395:Histocompatibility Antigens Class I; D009097:Multienzyme Complexes; D010455:Peptides; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex