Prolonged suppression of humoral immune response after organ transplantation.
Rats receiving either kidney or liver grafts were vaccinated with recombinant hepatitis B virus (HBV) vaccine either 1 or 10 weeks post-transplantation to explore the nonspecific immunosuppressive effect of transplantation surgery on antibody development. Response rate and geometric mean titer of the anti-HBs antibody were significantly lower in organ-transplanted animals undergoing early vaccination compared to unoperated control animals. Both parameters were affected when vaccination was performed early after kidney transplantation, but also in case of late vaccination in liver graft recipients. The nonspecific suppressive effect of transplantation surgery on the humoral immune response was related to the time point of vaccination after surgery and the extent of the surgical intervention and lasted longer than previously reported.
Gu
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YL
Department of General and Transplantation Surgery, University Hospital of Essen, Hufelandstrasse 55, D-45122 Essen, Germany.
Dahmen
U
U
Li
J
J
Dirsch
O
O
Polywka
S
S
Broelsch
C E
CE
D000818:Animals; D000917:Antibody Formation; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology; D007108:Immune Tolerance; D016030:Kidney Transplantation / Q000276:immunology; D016031:Liver Transplantation / Q000276:immunology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors; D014181:Transplantation Immunology; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology
C075654:Engerix-B; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic