[Phenytoin influence on human metanephros].
The influence of Phenytoin on the human embryo is knowing to produce the fetal hydantoin syndrome. Even this syndrome is knowing to produce microcephaly, mental retardation, eyelid ptosis etc it is not mentioned the influence of Phenytoin on the human metanephros. This is the reason of our study, made on human embryos. Their mothers received during pregnancy Phenytoin. In one studied embryo we have remarked a malformation in the metanephros. Even we can not make a strong correlation between the malformation and the Phenytoin we consider that pregnant women should not use Phenytoin during pregnancy.
Mihalache
G
G
Facultatea de Medicină Stomatologică, Disciplina de Anatomie şi Embriologie, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
Păduraru
D
D
Zamfir
C L
CL
Grigore
M
M
Filipoiu
F
F
Indrei
A
A
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000196:embryology; D010672:Phenytoin / Q000009:adverse effects*; D011247:Pregnancy
D000927:Anticonvulsants; D010672:Phenytoin