Apolipoprotein E genotype, lipid levels and coronary heart disease in a Polish population group.
Genotype of apolipoprotein E has been identified in a group of randomly selected Polish subjects participating in a cross-sectional study performed within the POL-MONICA Program, the part of international study WHO-MONICA Project. The investigated group consisted of 170 persons, 92 males and 78 females aged 41-69 years (mean age 62.0+/-5.11). The observed frequency of apolipoprotein E alleles was: epsilon2 - 7.6%, epsilon3 - 81.8% and epsilon4 - 10.6%, which was similar to frequencies in the neighbouring European countries. Statistically significant lower means of total cholesterol (TC) and of low density lipoprotein cholesterol (LDL-C) levels in epsilon2 carriers and higher means of TC, of LDL-C and of triglycerides in epsilon4 carriers were observed as compared with noncarriers of respective alleles. Some nonlipid cardiovascular risk factors (hypertension (HT) and obesity) and coronary heart disease (CHD) showed a tendency to lower prevalence in the epsilon2 allele carriers as compared to noncarriers. In the epsilon4 allele carriers a tendency to higher prevalence of HT, but not of CHD was observed as compared to noncarriers of this allele.
Bednarska-Makaruk
M
M
Institute of Psychiatry and Neurology, Department of Genetics, Warsaw, Poland. makaruk@ipin.edu.pl
Broda
G
G
Kurjata
P
P
Rodo
M
M
Roszczynko
M
M
Rywik
S
S
Wehr
H
H
D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D015995:Prevalence
D001057:Apolipoproteins E; D008055:Lipids