[Antibiotic combinations in Staphylococcus aureus infections: arguments against].
In a case of severe infection due to Staphylococcus aureus, generally accepted practice involves the use of a combination of antibiotics. This article examines the type and quality of the experimental and clinical data which has been collected in this context. Published findings suggest that the arguments in favour of combinations are usually theoretical, and that a demonstration of the superiority of combinations has never been made by comparative, randomised studies.
Albanese
J
J
Réanimation et centre de traumatologie, hôpital Nord, chemin des Bourrelly, 13915 Marseille, France.
Bourgouin
A
A
Martin
C
C
D000900:Anti-Bacterial Agents; D000075202:Contraindications; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents