Comments on the article 'Defining hormesis', by EJ Calabrese and LA Baldwin.
In view of the diversity of biological responses and the extent to which many of them remain poorly elucidated, there is merit in the suggestion by Calabrese and Baldwin that the term 'hormesis' should be applicable to those adaptive responses that are characterized by biphasic dose-response relationships, without reference to any associated beneficial or harmful effects. Whether the dose-response relationships for radiation-induced mutations and chromosome aberrations are biphasic in nature is an important question that remains to be resolved.
Upton
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AC
Environmental and Occupational Health Sciences Institute, New Brunswick, New Jersey 08901, USA. acupton@eohsi.rutgers.edu
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D009369:Neoplasms / Q000209:etiology; D019055:No-Observed-Adverse-Effect Level; D011955:Receptors, Drug / Q000187:drug effects / Q000528:radiation effects; D012308:Risk Management
D011955:Receptors, Drug