Homocysteine, vitamin B(6), and lipid in cardiovascular disease.
OBJECTIVE
Elevated homocysteine (Hcy) is considered an independent risk factor for cardiovascular disease (CVD). An elevated plasma Hcy level may interact with conventional CVD risk factors to further increase vascular disease risk. Therefore, we investigated the plasma levels of Hcy, vitamin B(6) status (pyridoxal phosphate and pyridoxal), and lipid profile in patients with CVD.


METHODS
Possible associations between sex, age, body mass index (BMI), and waist-to-hip ratio (WHR) to levels of plasma Hcy and plasma Hcy to vitamin B(6) status and lipid profile were examined.


RESULTS
Plasma Hcy level, body mass index, and waist-to-hip ratio were significantly higher in patients with CVD than in controls. Male CVD patients had significantly higher plasma Hcy levels than did female patients. Plasma levels of pyridoxal phosphate and total B(6) aldehyde were significantly higher in male than in female patients. Plasma Hcy levels of patients did not correlate to their plasma vitamin B(6) status or to their lipid profiles. Plasma Hcy level correlated positively with age, body mass index, and waist-to-hip ratio (P < 0.0001).


CONCLUSIONS
This suggested that patients with CVD have higher levels of plasma Hcy that are influenced by sex, age, body mass index, and waist-to-hip ratio and not by their plasma vitamin B(6) status and lipid profiles.
Chan
Sue-Joan
SJ
Department of Biology, National Cheng Kung University, Tainan, Taiwan 701, R.O.C. sjchang@mail.ncku.edu.tw
Chang
Chen-Nen
CN
Hsu
Jee-Ching
JC
Lee
Ying-Shiung
YS
Shen
Chen-Hsiang
CH
D000328:Adult; D000368:Aged; D001824:Body Constitution; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000097:blood; D025101:Vitamin B 6 / Q000097:blood*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D006710:Homocysteine; D011732:Pyridoxal Phosphate; D025101:Vitamin B 6; D002784:Cholesterol