title: The FAS-670 polymorphism influences susceptibility to multiple sclerosis.
abstract: Several studies have reported a defective Fas function in patients with multiple sclerosis (MS). We were interested whether this could result from a genetically altered Fas regulation. We examined the FAS-670 polymorphism in 382 patients with MS and 206 controls, and found that the carriership of allele FAS-670*G was significantly less frequent in patients than in controls. We found no association between the carriership of FAS-670*G and clinical features. For a subgroup of patients, longitudinal MRI data were available. We observed similar brain and lesion volumes in carriers and noncarriers of FAS-670*G. These data suggest that FAS-670*G decreases the risk of developing MS, but does not affect the course of disease.
authors.affiliation: Department of Neurology, VU Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
authors.forename: T
authors.initials: T
authors.lastname: van Veen
authors.forename: N F
authors.initials: NF
authors.lastname: Kalkers
authors.forename: J B A
authors.initials: JB
authors.lastname: Crusius
authors.forename: L
authors.initials: L
authors.lastname: van Winsen
authors.forename: F
authors.initials: F
authors.lastname: Barkhof
authors.forename: P J H
authors.initials: PJ
authors.lastname: Jongen
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
authors.forename: C H
authors.initials: CH
authors.lastname: Polman
authors.forename: B M J
authors.initials: BM
authors.lastname: Uitdehaag
mesh_terms: D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D053222:Fas Ligand Protein; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors; D019014:fas Receptor / Q000235:genetics* / Q000276:immunology
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor; D016899:Interferon-beta