title: A randomized comparison of the effects of budesonide and mometasone furoate aqueous nasal sprays on nasal peak flow rate and symptoms in perennial allergic rhinitis.
abstract: BACKGROUND
  Using conventional methods, it has been difficult to show differences in efficacy between intranasal corticosteroids in perennial rhinitis.
  
  
  OBJECTIVE
  To compare the effects of budesonide and mometasone on nasal symptoms and nasal airflow in perennial allergic rhinitis.
  
  
  METHODS
  Four hundred thirty-eight patients (age > 18 years old) were randomized to budesonide, 256 microg or 128 microg, mometasone furoate 200 microg, or placebo, once daily for 4 weeks. Efficacy was evaluated by nasal index score (NIS; the sum of scores for blocked nose, runny nose, and itchy nose/sneezing) and peak nasal inspiratory flow (PNIF).
  
  
  RESULTS
  All three active treatments significantly reduced the NIS compared with placebo. There was no significant difference between the treatments, although the effect of budesonide, 256 microg, tended to be greater than that of the other regimens. PNIF was significantly improved with all three active treatments: the effect of budesonide 256 microg on morning and evening PNIF was significantly greater than that of mometasone furoate and 128 microg budesonide. Budesonide had a rapid onset of action, showing a significantly greater effect on evening PNIF than mometasone furoate during the first 10 days. For all active treatments, significant improvements in NIS were seen within 4 hours of the first dose. All three treatments were well tolerated.
  
  
  CONCLUSIONS
  The objective parameter PNIF was capable of demonstrating greater efficacy of budesonide 256 microg compared with budesonide 128 microg and mometasone furoate 200 microg, whereas the combined nasal symptom score could only distinguish active treatment from placebo.
authors.affiliation: Department of Otorhinolaryngology, Central Hospital, Skövde, Sweden. bende@artech.se
authors.forename: Mats
authors.initials: M
authors.lastname: Bende
authors.forename: Teresa
authors.initials: T
authors.lastname: Carrillo
authors.forename: Ida
authors.initials: I
authors.lastname: Vóna
authors.forename: Maria Graça
authors.initials: MG
authors.lastname: da Castel-Branco
authors.forename: Lars
authors.initials: L
authors.lastname: Arheden
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006814:Hungary; D007320:Inspiratory Capacity; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate; D009666:Nose; D011174:Portugal; D011244:Pregnadienediols / Q000008:administration & dosage / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D013030:Spain; D013548:Sweden
chemical_list: D011244:Pregnadienediols; D000068656:Mometasone Furoate; D019819:Budesonide