Expression of p63 and 14-3-3sigma in normal and hyperdifferentiated mucosa of the upper aerodigestive tract.
OBJECTIVE
Our goal was to analyze p63 and 14-3-3sigma expression in normal and hyperdifferentiated head and neck mucosa.


METHODS
Compare the in vivo expression of p63 and 14-3-3sigma by immunohistochemistry in normal mucosa and oral lichen planus, a benign mucosal lesion marked by hyperdifferentiation and apoptosis.


CONCLUSIONS
p63 is underexpressed and 14-3-3sigma is overexpressed in lichen planus on immunohistochemical analysis.


CONCLUSIONS
The findings support the hypothesis that p63 plays an antidifferentiation role, whereas 14-3-3sigma plays a prodifferentiation role in the upper aerodigestive tract epithelium. Lichen planus is a valuable model for the study of p63, 14-3-3sigma, and mucosal differentiation. p63 and 14-3-3sigma may be molecular markers for oral lichen planus.
Sniezek
Joseph C
JC
Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN 96859-5000, USA. sniezeks@aol.com
Matheny
Keith E
KE
Burkey
Brian B
BB
Netterville
James L
JL
Pietenpol
Jennifer A
JA
D048948:14-3-3 Proteins; D015415:Biomarkers / Q000032:analysis; D046508:Culture Techniques; D004268:DNA-Binding Proteins; D016147:Genes, Tumor Suppressor; D006801:Humans; D007150:Immunohistochemistry; D017676:Lichen Planus, Oral / Q000473:pathology*; D008565:Membrane Proteins; D009061:Mouth Mucosa / Q000473:pathology; D010750:Phosphoproteins / Q000032:analysis*; D011230:Precancerous Conditions / Q000473:pathology*; D012016:Reference Values; D012680:Sensitivity and Specificity; D015534:Trans-Activators / Q000032:analysis*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*
D048948:14-3-3 Proteins; D015415:Biomarkers; C081876:CKAP4 protein, human; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D014446:Tyrosine 3-Monooxygenase