Synchronous triple cancers at middle and lower esophagus and stomach with different histological features and genetic alterations.
Synchronous multiple primary malignancies are relatively unusual. We describe a case of synchronous triple cancers located at the middle and lower esophagus and the stomach in a 59-year-old Taiwanese man who presented with progressive dysphagia, epigastralgia, and bodyweight loss in 1 month. Endoscopic and histological features, microsatellite instability status of genomic DNA, and immunohistochemical staining of p53, MUC2, Fhit, c-erbB-2 and E-cadherin of all three cancers were demonstrated. We noted that these three cancers arose from different clones and that p53 mutation, instead of microsatellite instability, may play a major role in the development of multiple primary malignancies in this patient.
Chang
Yu-Ting
YT
Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.
Tsai
Chun-I
CI
Yang
Tzeng-Huey
TH
Shih
Chia-Wen
CW
Wu
Ming-Shiang
MS
Lin
Jaw-Town
JT
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology*; D004945:Esophagoscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*