title: Transactivation of the human endogenous retrovirus K long terminal repeat by herpes simplex virus type 1 immediate early protein 0.
abstract: We found that LTR-directed transcription of the human endogenous retrovirus K can be induced by HSV-1 infection. The effect was mediated by the action of a HSV-1 immediate early protein, ICP0 and required the AP-1 binding site present on the HERV-K LTR. In addition, ICP0 could up-regulate AP-1 activity, suggesting that ICP0 increases transcription of HERV-K through AP-1 site. This effect might be important to understand both HERV-K- and HSV-1-mediated pathogenesis because HERV-K LTR represents an important class of retrotranspositional mutagens and also could provide a new regulatory element for the linked DNA sequences.
authors.affiliation: Department of Microbiology, College of Natural Sciences, Pusan National University, Pusan, South Korea.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kwun
authors.forename: Hae Jin
authors.initials: HJ
authors.lastname: Han
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Lee
authors.forename: Hee Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Kyung Lib
authors.initials: KL
authors.lastname: Jang
mesh_terms: D018259:Herpesvirus 1, Human / Q000737:chemistry; D006801:Humans; D017874:Immediate-Early Proteins / Q000502:physiology*; D008156:Luciferases / Q000235:genetics / Q000378:metabolism; D012190:Retroviridae / Q000145:classification / Q000235:genetics*; D020079:Terminal Repeat Sequences / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*; D015533:Transcriptional Activation / Q000502:physiology*; D014407:Tumor Cells, Cultured
chemical_list: C050678:IE1 protein, Human herpesvirus 1; D017874:Immediate-Early Proteins; D008156:Luciferases