[Plasma Lp (a) levels and correlation of Lp (a) with fibrinolysis activation in chronic renal failure].
Plasma Lp (a) concentration and activation of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1) were determined in 50 patients with chronic renal failure (CRF) and in 50 healthy subjects. The results demonstrated that plasma concentration of Lp(a) was significantly higher and plasma t-PA activation was significantly lower in CRF patients than in healthy subjects. With multivariate analyses, plasma Lp(a) concentration was positively correlated with the total amount of 24 h uric protein, plasma BUN and uric protein concentration. Moreover, a negative significant correlation between plasma Lp(a) levels and t-PA activation was observed. Plasma Lp(a) levels did not show a correlation to PAI-1 activation. It is indicated that renal function may contribute to moderate plasma Lp(a) concentration and elevated Lp(a) levels may be related with fibrinolytic impairment.
Zhu
J
J
Department of Kidney Internal Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Xiong
X
X
Zhao
S
S
Wang
Z
Z
Lou
L
L
Hang
Q
Q
D000328:Adult; D001054:Apolipoproteins A / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood
D001054:Apolipoproteins A; D017270:Lipoprotein(a); D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator