Chemotactic signaling pathways in neutrophils: from receptor to actin assembly.
In this review, we present an overview of the signaling elements between neutrophil chemotactic receptors and the actin cytoskeleton that drives cell motility. From receptor-ligand interactions, activation of heterotrimeric G-proteins, their downstream effectors PLC and PI-3 kinase, the activation of small GTPases of the Rho family, and their regulation of particular cytoskeletal regulatory proteins, we describe pathways specific to the chemotaxing neutrophil and elements documented to be important for neutrophil function.
Cicchetti
Gregor
G
Hematology Division, Harvard Medical School, Brigham and Women's Hospital, LMRC 301, Boston, MA 02115, USA.
Allen
Philip G
PG
Glogauer
Michael
M
D000199:Actins / Q000378:metabolism* / Q000502:physiology; D002630:Chemotactic Factors / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism* / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D018375:Neutrophil Activation / Q000502:physiology; D020556:Neutrophil Infiltration / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000502:physiology
D000199:Actins; D002630:Chemotactic Factors; D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; D019869:Phosphatidylinositol 3-Kinases; D010738:Type C Phospholipases; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D020741:rho GTP-Binding Proteins