title: [Effect of recombinant activated factor VII (RFVIIA; NovoSeven) in a patient in haemorrhagic shock after obstetrical hysterectomy].
abstract: Perinatal bleeding may lead to a fatal outcome in about 10% of cases. We present a case of a 29 year old woman in childbirth, in whom a preparation of recombinant activated factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S, Bagsvaerd, Denmark) was used with success to control intraoperative bleeding during haemorrhagic shock after caesarean section and obstetrical hysterectomy, in the course of the patient's third abdominal cavity revision for continuing blood loss. Administration of the preparation enabled for quick intraoperative control of haemorrhage, which allowed safe and clear identification and elimination of the cause of bleeding. No significant clotting abnormalities were noted at postoperative monitoring of the coagulation system. rFVIIa seems to be an effective alternative treatment of life-threatening haemorrhages in obstetrics, allowing for quick arrest of bleeding, and thus safe control of intraoperative local hemostasis.
authors.affiliation: Zakładu Anestezjologii w Ginekologii i Połoznictwie Instytutu Anestezjologii i Intensywnej Terapii Akademii Medycznej w Poznaniu.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Sobieszczyk
authors.forename: Grzegorz H
authors.initials: GH
authors.lastname: Breborowicz
authors.forename: Wiesław
authors.initials: W
authors.lastname: Markwitz
authors.forename: Stanisław
authors.initials: S
authors.lastname: Mallinger
authors.forename: Dariusz
authors.initials: D
authors.lastname: Adamski
authors.forename: Zdzisław
authors.initials: Z
authors.lastname: Kruszyński
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D016063:Blood Loss, Surgical / Q000517:prevention & control; D002585:Cesarean Section / Q000009:adverse effects*; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006473:Postpartum Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy* / Q000209:etiology; D011256:Pregnancy Outcome; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa