[Changes in lipoprotein (a) and the relation between lipoprotein (a) and endothelin in patients during upper abdominal surgery].
OBJECTIVE
We observed the changes in both serum lipoprotein(a) [Lp(a)] and plasma endothelin (ET) during upper abdominal surgery under intravenous combined with inhalation anesthesia and we also analyzed their correlativity.


METHODS
Fifteen patients, scheduled for upper abdominal surgery, were anesthetized with total does of fentanal 8-12 micrograms.kg-1 and inhalation of 1-2 MAC enflurane. Serum Lp(a) and plasma ET at pre-anesthesia, pre-operation, 1 h from the start of operation and 30 min after operation were determined.


RESULTS
The average concentrations of Lp(a) and ET were increased at 1 h from the start of operation compared with pre-anesthesia, but had no statistical significance. Lp(a) and ET were significantly higher at 30 min after operation than pre-anesthesia(P < 0.05).


CONCLUSIONS
Lp(a) and ET have a close relation in advancing cardio-cerebral blood vessel diseases.
Zhang
H
H
Department of Anesthesiology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Cai
H
H
Tan
X
X
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D001660:Biliary Tract Diseases / Q000097:blood / Q000601:surgery; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013272:Stomach Diseases / Q000097:blood / Q000601:surgery
D016232:Endothelins; D017270:Lipoprotein(a)