title: Studies of piroxicam absorption by oral mucosa.
abstract: The present study was undertaken to investigate, if the non-steroidal anti-inflammatory drug (NSAID) piroxicam (CAS 36322-90-4) Fast-Dissolving Dosage Form (FDDF) can be absorbed in the oral mucosa. Piroxicam FDDF was administrated under the tongue to rats with an oesophagus ligation (OL) to prevent the drug entering the stomach and in turn its absorption by the classic way. A group of sham-operated (SO) animals received the same piroxicam FDDF dose. After drug administration, a pharmacokinetic study with serial serum sample extractions at 0, 15, 30, 60 and 120 min was performed. It has been found a prompt increase in serum piroxicam levels in OL-rats, which showed different pharmacokinetics from SO-rats. Areas under curve (AUCs) of OL-rat serum piroxicam levels were higher at 15, 30 and 60 min compared to SO-animals. These results indicate that piroxicam FDDF is absorbed in the rat oral mucosa. Moreover, during the first hour, drug absorption by oral mucosa rendered higher piroxicam levels than gastric absorption.
authors.affiliation: Inflammation Unit, Division of Rheumatology, Jiménez Díaz Foundation, Universidad Autónoma, Madrid, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Diez-Ortego
authors.forename: Margarida
authors.initials: M
authors.lastname: Cruz
authors.forename: Raquel
authors.initials: R
authors.lastname: Largo
authors.forename: Antonio
authors.initials: A
authors.lastname: Navarro
authors.forename: Itziar
authors.initials: I
authors.lastname: Palacios
authors.forename: Ana
authors.initials: A
authors.lastname: Solans
authors.forename: Olga
authors.initials: O
authors.lastname: Sanchez-Pernaute
authors.forename: Jesús
authors.initials: J
authors.lastname: Egido
authors.forename: Gabriel
authors.initials: G
authors.lastname: Herrero-Beaumont
mesh_terms: D000042:Absorption; D000286:Administration, Sublingual; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D009061:Mouth Mucosa / Q000378:metabolism*; D010894:Piroxicam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam