NK cell receptors in antiviral immunity.
An array of inhibitory and activating receptors initially identified on NK cells are also expressed by conventional CD8+ alphabeta T cells. New evidence strongly implicates these 'NK cell receptors' in modulating NK cell and virus-specific CD8+ T cell responses against a variety of viral infections. Precise regulation of NK cell and T cell responses by these receptors optimizes antiviral immunity while preventing immunological bystander pathology and autoimmunity.
Moser
Janice M
JM
Department of Pathology, Woodruff Memorial Research Building, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA.
Byers
Anthony M
AM
Lukacher
Aron E
AE
D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D011971:Receptors, Immunologic / Q000502:physiology*; D054340:Receptors, KIR; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000472:pathogenicity
D011971:Receptors, Immunologic; D054340:Receptors, KIR