title: [Relationship between brain edema induced by freezing injury and concentration of Evan blues and cytosolic free calcium in brain tissues].
abstract: The authors studied the changes of Evan blues(EB) of brain tissues and concentration of cytosolic free calcium ([Ca2+]i), and relationship between them and water content of brain tissues following freezing brain edema in rats, to elucidate mechanism and type of brain edema induced by freezing injury. The results indicated that there were close positive relationship between water content and EB of brain tissues, and between [Ca2+]i and water content. We found that not only cytotoxic brain edema(intracellular edema) occurred but also occurred vasogenic brain edema(extracellular edema) followed by blood brain barrier breakdown after brain edema. Freezing brain edema is mixed brain edema.
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Hunan Medical University, Changsha 410008.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D001812:Blood-Brain Barrier; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism*; D002118:Calcium; D004396:Coloring Agents; D005070:Evans Blue; D005260:Female; D005615:Freezing; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004396:Coloring Agents; D005070:Evans Blue; D002118:Calcium