title: [Clinical and pathogenic significance of tumor necrosis factor-alpha in systemic lupus erythematosus].
abstract: OBJECTIVE
  To examine the level of tumor necrosis factor-alpha (TNFa) in the sera from patients with systemic lupus erythematosus (SLE) and its clinical and pathogenic role.
  
  
  METHODS
  TNFa was measured with ELISA (Immunogenetics N.V., Belgium) in the sera from 147 SLE patients (70 men and 77 women). The results were compared with those of 20 healthy subjects.
  
  
  RESULTS
  TNFa elevated concentrations were found in 49% examinees with SLE. Concentration of TNFa, SLE activity and development of antiphospholipid syndrome correlated.
  
  
  CONCLUSIONS
  The findings indicate that TNFa is involved in pathogenesis of SLE. Quantitation of TNFa may serve a useful tool for monitoring SLE activity.
authors.forename: A G
authors.initials: AG
authors.lastname: Borodin
authors.forename: A A
authors.initials: AA
authors.lastname: Baranov
authors.forename: N G
authors.initials: NG
authors.lastname: Kliukvina
authors.forename: N E
authors.initials: NE
authors.lastname: Abaĭtova
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha