title: Virulence genes in Helicobacter pylori strains from West Bengal residents with overt H. pylori-associated disease and healthy volunteers.
abstract: We compared putative molecular markers of virulence (vacA, cagA, and iceA) of Helicobacter pylori strains isolated from 52 adult duodenal ulcer patients from West Bengal, India, with those of H. pylori strains isolated from 48 adult healthy volunteers from the same region. On the basis of genotyping by PCR, we conclude that the H. pylori strains isolated from the two study groups were indistinguishable and that there are geographic variations in the association of certain putative H. pylori virulence genes with clinical status.
authors.affiliation: National Institute of Cholera and Enteric Diseases, Calcutta, India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Chattopadhyay
authors.forename: Simanti
authors.initials: S
authors.lastname: Datta
authors.forename: Abhijit
authors.initials: A
authors.lastname: Chowdhury
authors.forename: Sujit
authors.initials: S
authors.lastname: Chowdhury
authors.forename: Asish K
authors.initials: AK
authors.lastname: Mukhopadhyay
authors.forename: K
authors.initials: K
authors.lastname: Rajendran
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Berg
authors.forename: G Balakrish
authors.initials: GB
authors.lastname: Nair
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D016022:Case-Control Studies; D004381:Duodenal Ulcer / Q000382:microbiology; D005260:Female; D005798:Genes, Bacterial; D005838:Genotype; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D007194:India; D008297:Male; D014774:Virulence / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori; C063113:ice nucleation protein