title: Adrenocorticotropin-producing pituitary carcinoma with metastasis to the liver in a patient with Cushing's disease.
abstract: A 61-year-old woman who had a nonfunctioning pituitary tumor removed was later found to have a pituitary carcinoma with metastasis to the liver that produced adrenocorticotropic hormone (ACTH), causing Cushing's disease. Despite the second removal of the pituitary tumor, Cushing's disease persisted. Endocrinologic examination demonstrated marked elevation of plasma ACTH, beta-endorphin, and serum cortisol concentrations, which were not suppressed by low- or high-dose dexamethasone administration. A computed tomographic scan of the abdomen revealed a solitary hypodense area in the liver consistent with a metastatic lesion. Immediately after resection of the liver tumor, plasma ACTH concentrations fell to normal range. Such a decline in ACTH secretion was not observed even after the pituitary tumor was removed. Histologic characteristics of both the pituitary and liver tumors were similar. The immunohistochemical study using anti-ACTH antibody showed similar ACTH-positive cells in the pituitary and liver tumors. Based on these findings, the patient was diagnosed as having liver metastasis of ACTH-secreting pituitary carcinoma. This is the first case report in which a metastatic liver tumor of a pituitary carcinoma caused ACTH.
authors.affiliation: Department of Homeostatic Regulation and Development, Niigata Graduate School of Medical and Dental Sciences, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Suzuki
authors.forename: Ken
authors.initials: K
authors.lastname: Morii
authors.forename: Junichi
authors.initials: J
authors.lastname: Nakamura
authors.forename: Susumu
authors.initials: S
authors.lastname: Kaneko
authors.forename: Junko
authors.initials: J
authors.lastname: Ukisu
authors.forename: Osamu
authors.initials: O
authors.lastname: Hanyu
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakagawa
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000556:secondary*; D003480:Cushing Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D000324:Adrenocorticotropic Hormone