Autoantibodies to transducin in a patient with melanoma-associated retinopathy.
OBJECTIVE
To report novel immunoreactivity in a patient with melanoma-associated retinopathy.


METHODS
Retrospective case report and experimental study.


METHODS
A 32-year-old woman with a history of metastatic melanoma presented with bilateral decreased visual acuity. Electroretinography, Goldmann perimetry, immunohistochemistry, and Western blotting of her serum were performed.


RESULTS
Electroretinography showed a "negative" B-wave. Paracentral and central scotomas were observed on Goldmann perimetry. Antibodies to a retinal transducin were demonstrated by Western blotting. No immunoreactivity to retinal bipolar cells was detected by immunohistochemistry.


CONCLUSIONS
Melanoma-associated retinopathy can be related to a variety of antiretinal antibodies. Recognition of transducin, a novel melanoma-associated retinopathy antigen, may be important for identifying and treating patients with night blindness and melanoma.
Potter
Michael J
MJ
Department of Ophthalmology, University of British Columbia, Vancouver, Canada. mpotter@interchange.ubc.ca
Adamus
Grazyna
G
Szabo
Shelagh M
SM
Lee
Rehwa
R
Mohaseb
Kam
K
Behn
Darren
D
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D015153:Blotting, Western; D004596:Electroretinography; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000150:complications* / Q000556:secondary; D009755:Night Blindness / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D012189:Retrospective Studies; D012607:Scotoma / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D015293:Transducin / Q000276:immunology*; D014792:Visual Acuity; D058609:Visual Field Tests
D001323:Autoantibodies; D001324:Autoantigens; D015293:Transducin