title: Solitary fibrous tumor of the tongue: report of a case with immunohistochemical and ultrastructural studies.
abstract: Solitary fibrous tumors are rare in extrapleural sites and extremely rare in the oral cavity. We report a case of a solitary fibrous tumor arising from the tongue of a 70-year-old woman. The tumor measured 1.6 cm in maximum diameter and consists of spindle-shaped cells distributed in a haphazard pattern. Immunohistochemical studies show strong positivity for CD34 and bcl-2, and weak positivity for desmin. Smooth muscle actin and S-100 protein are negative. Electron microscopy shows uniform neoplastic spindle cells with mesenchymal features. The differential diagnosis for spindle cell neoplasms in the tongue is discussed.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas - Houston Medical School, Houston, TX 77030, USA.
authors.forename: Sang Ling
authors.initials: SL
authors.lastname: Wu
authors.forename: Russell
authors.initials: R
authors.lastname: Vang
authors.forename: Fred J
authors.initials: FJ
authors.lastname: Clubb
authors.forename: John H
authors.initials: JH
authors.lastname: Connelly
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002467:Cell Nucleus / Q000648:ultrastructure; D018870:Endoplasmic Reticulum, Rough / Q000648:ultrastructure; D005260:Female; D005350:Fibroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D009363:Neoplasm Proteins / Q000378:metabolism; D014062:Tongue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins