Oltipraz protects the passive smoke induced changes in renal glyoxalase system of rats.
The present study was performed to investigate the effect of oltipraz on passive smoke-induced alteration in renal glyoxalase system of rats. Adult Sprague-Dawley rats were exposed daily to passive cigarette smoke in a whole-body exposure chamber 6 h per day for 2, 4 and 12 weeks. The animals being sacrificed after 2 and 12 weeks were maintained on control diet, powdered 4% Teklad rat chow (Harlan Teklad, Madison, WI, USA). The 4 weeks group was divided into three subgroups, one receiving control diet, other two receiving control diet supplemented with two doses of oltipraz (either 167 or 500 ppm), starting 1 week prior to initiation of smoke exposure until the end of the experiment. The activity of glyoxalase I was higher in animals exposed for 4 and 12 weeks of passive smoke than those exposed for 2 weeks. There was no significant difference between 4 and 12 weeks. Glyoxalase II activity was lower in animals exposed to passive smoke for 4 weeks than those exposed for 2 weeks. However, the activity approached the basal level after 12 weeks of exposure. Furthermore, oltipraz treatment maintained the activity of both glyoxalase closer to the basal levels.
Biswas
Swati
S
Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA.
Gairola
C Gary
CG
Das
Salil K
SK
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology / Q000517:prevention & control*; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013869:Thiolester Hydrolases / Q000378:metabolism*; D013871:Thiones; D013876:Thiophenes; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D000099301:Hydroxyacylglutathione Hydrolase
D016588:Anticarcinogenic Agents; D007791:Lactoylglutathione Lyase; D011719:Pyrazines; D013869:Thiolester Hydrolases; D013871:Thiones; D013876:Thiophenes; D014028:Tobacco Smoke Pollution; D000099301:Hydroxyacylglutathione Hydrolase; C026209:oltipraz