Protection by methyl inosine monophosphate (MIMP) against aerosol influenza virus infection in mice.
Methyl inosine monophosphate (MIMP) is a novel thymomimetic purine immunomodulator capable of enhancing a wide variety of immune responses. Intravenous (i.v.) administration of MIMP 1 day prior to influenza virus infection could confer partial protection and significantly increase the mean survival of treated mice. Intranasal (i.n.) administration of MIMP improved survival rates and incorporation of MIMP in squalane-saline emulsion 1 day prior to or 1 h after influenza infection conferred complete protection. Mice administered MIMP had reduced levels of lung virus and lower titers of circulating serum hemagglutination-inhibition (HI) antibodies. Complete survival and reduction of viral load after influenza challenge infection suggests effective stimulation by MIMP of protective responses against influenza virus.
Masihi
K Noel
KN
Robert Koch Institute, Berlin, Germany. masihik@rki.de
Hadden
John W
JW
D000336:Aerosols; D000818:Animals; D005260:Female; D009980:Influenza A virus / Q000187:drug effects; D007291:Inosine Monophosphate / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000097:blood / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control*; D015996:Survival Rate
D000336:Aerosols; D007291:Inosine Monophosphate; C076557:methyl inosine monophosphate