Clinical trials of intracoronary gamma radiation therapy for in-stent restenosis.
The only gamma emitter used in clinical trials for in-stent restenosis is 192Iridium (192Ir). The efficacy of intracoronary gamma radiation therapy in reducing clinical and angiographic restenosis in patients with in-stent restenosis has been established. This review is intended to give an overview of the clinical trials utilizing gamma vascular brachytherapy in patients with in-stent restenosis and give insight into the future of intracoronary radiation therapy.
Cha
Dong-Hun
DH
Cardiovascular Research Institute, Washington, DC 20010, USA.
Ajani
Andrew E
AE
Cheneau
Edouard
E
Waksman
Ron
R
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D001918:Brachytherapy / Q000379:methods*; D023903:Coronary Restenosis / Q000532:radiotherapy*; D023921:Coronary Stenosis / Q000175:diagnosis / Q000628:therapy*; D003331:Coronary Vessels / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D015607:Stents / Q000009:adverse effects*; D016896:Treatment Outcome