title: Gene expression correlates of clinical prostate cancer behavior.
abstract: Prostate tumors are among the most heterogeneous of cancers, both histologically and clinically. Microarray expression analysis was used to determine whether global biological differences underlie common pathological features of prostate cancer and to identify genes that might anticipate the clinical behavior of this disease. While no expression correlates of age, serum prostate specific antigen (PSA), and measures of local invasion were found, a set of genes was identified that strongly correlated with the state of tumor differentiation as measured by Gleason score. Moreover, a model using gene expression data alone accurately predicted patient outcome following prostatectomy. These results support the notion that the clinical behavior of prostate cancer is linked to underlying gene expression differences that are detectable at the time of diagnosis.
authors.affiliation: Department of Adult Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Singh
authors.forename: Phillip G
authors.initials: PG
authors.lastname: Febbo
authors.forename: Kenneth
authors.initials: K
authors.lastname: Ross
authors.forename: Donald G
authors.initials: DG
authors.lastname: Jackson
authors.forename: Judith
authors.initials: J
authors.lastname: Manola
authors.forename: Christine
authors.initials: C
authors.lastname: Ladd
authors.forename: Pablo
authors.initials: P
authors.lastname: Tamayo
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Renshaw
authors.forename: Anthony V
authors.initials: AV
authors.lastname: D'Amico
authors.forename: Jerome P
authors.initials: JP
authors.lastname: Richie
authors.forename: Eric S
authors.initials: ES
authors.lastname: Lander
authors.forename: Massimo
authors.initials: M
authors.lastname: Loda
authors.forename: Philip W
authors.initials: PW
authors.lastname: Kantoff
authors.forename: Todd R
authors.initials: TR
authors.lastname: Golub
authors.forename: William R
authors.initials: WR
authors.lastname: Sellers
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D015203:Reproducibility of Results; D012307:Risk Factors; D016896:Treatment Outcome