Evaluation of a new controlled-drug delivery concept based on the use of thermoresponsive polymers.
The purpose of this work is to develop a new delivery concept making a thermosensitive polymer based on poly(N-isopropylacrylamide) (PNIPAAm) useful as a time-controlled drug release device, without any temperature changes of the dissolution medium. It was previously found that some salts induce a decrease of the polymer lower critical solution temperature (LCST). Use is here made of that property to show that salt concentration variations can be used as a substitute for temperature changes to make the polymer coating of compression-coated tablets soluble or insoluble, consequently creating a possible new concept of drug delivery control from delivery systems containing thermoresponsive polymers. The obtained results show the influence of the type and amount of salts incorporated into compression-coated tablets on the release lag time of a model drug.
Eeckman
Frederic
F
Laboratoire de Pharmacie Galénique et de Biopharmacie, Université libre de Bruxelles, Campus Plaine, CP-207, Boulevard du Triomphe, 1050, Brussels, Belgium.
Moës
André J
AJ
Amighi
Karim
K
D000180:Acrylic Resins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006358:Hot Temperature; D007202:Indicators and Reagents; D008970:Molecular Weight; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D007202:Indicators and Reagents; D011108:Polymers; D013607:Tablets; C052970:poly-N-isopropylacrylamide; D013806:Theophylline