title: Spiroidesin, a novel lipopeptide from the cyanobacterium Anabaena spiroides that inhibits cell growth of the cyanobacterium Microcystis aeruginosa.
abstract: Spiroidesin (1), a novel D-amino acid-containing linear lipopeptide, was isolated from waterblooms of the cyanobacterium Anabaena spiroides. The structure was identified by 2D NMR and chemical degradation analyses. Spiroidesin inhibited cell growth of the toxic cyanobacterium Microcystis aeruginosa (IC(50), 1.6 x 10(-6) M).
authors.affiliation: Laboratory of Intellectual Fundamentals for Environmental Studies, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan. kayakuni@nies.go.jp
authors.forename: Kunimitsu
authors.initials: K
authors.lastname: Kaya
authors.forename: Aparat
authors.initials: A
authors.lastname: Mahakhant
authors.forename: Ladda
authors.initials: L
authors.lastname: Keovara
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Sano
authors.forename: Takuya
authors.initials: T
authors.lastname: Kubo
authors.forename: Hiroo
authors.initials: H
authors.lastname: Takagi
mesh_terms: D017033:Anabaena / Q000737:chemistry* / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D020128:Inhibitory Concentration 50; D055666:Lipopeptides; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D046931:Microcystis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides; D013785:Thailand
chemical_list: D000900:Anti-Bacterial Agents; D055666:Lipopeptides; D008074:Lipoproteins; D010455:Peptides; C464986:spiroidesin