Novel diterpene lactones from Suregada multiflora.
Two new diterpene lactones, suregadolides A (1) and B (2), were isolated from a dichloromethane extract of Suregada multiflora bark. These compounds possess a novel skeleton, which contains a cyclopropane ring bridging C-3 and C-4 of the abietane skeleton. The structures were established on the basis of one- and two-dimensional NMR and other spectroscopic studies. Compound 1 showed moderate inhibitory activity in a mutant yeast strain bioassay.
Jahan
Ismet Ara
IA
Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.
Nahar
Nilufar
N
Mosihuzzaman
M
M
Shaheen
Farzana
F
Parween
Zeba
Z
Atta-ur-Rahman
Choudhary
M Iqbal
MI
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001459:Bangladesh; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D030781:Organisms, Genetically Modified; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013237:Stereoisomerism
D000935:Antifungal Agents; D004224:Diterpenes; D007783:Lactones; C464990:suregadolide A; C464991:suregadolide B