title: Keloidal fibromas and fibrosarcomas in the dog.
abstract: Sixteen dogs (2-12 years of age) presented with one (n = 15) or two (n = 1) cutaneous nodules (n = 16) or a dermal plaque (n = 1). Intact males (n = 9) and neutered males (n = 4) were more affected than were females (n = 3). Histologically, these lesions were characterized by focal dermal and subcutaneous deposition of thick hyalinized collagen fibers intermingled with fibroblasts, and in 13 of 17 lesions, a variable number of CD18-positive cells were interpreted as reactive macrophages. Fibroblasts in three dogs formed intersecting fascicles, interpreted as evidence of malignant transformation. The terms keloidal fibroma and keloidal fibrosarcoma can be applied to these lesions. Excision was curative in five dogs with keloidal fibroma for which follow-up was available. However, because malignant transformation may occur, wide excision of canine keloidal lesions is warranted.
authors.affiliation: Idexx Veterinary Services, West-Sacramento, CA 95605, USA.
authors.forename: I
authors.initials: I
authors.lastname: Mikaelian
authors.forename: T L
authors.initials: TL
authors.lastname: Gross
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D005350:Fibroma / Q000473:pathology / Q000662:veterinary*; D005354:Fibrosarcoma / Q000473:pathology / Q000662:veterinary*; D007627:Keloid / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D012867:Skin / Q000473:pathology