The therapeutic potential of modulating the ceramide/sphingomyelin pathway.
Kolesnick
Richard
R
Laboratory of Signal Transduction, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. r-kolesnick@ski.mskcc.org
D000581:Amidohydrolases / Q000378:metabolism; D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D055592:Biophysical Phenomena; D001703:Biophysics; D055572:Ceramidases; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000628:therapy; D023903:Coronary Restenosis / Q000517:prevention & control; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D010088:Oxidoreductases / Q000378:metabolism; D015290:Second Messenger Systems; D015398:Signal Transduction; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013109:Sphingomyelins / Q000737:chemistry / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000378:metabolism
D002518:Ceramides; D013109:Sphingomyelins; D010088:Oxidoreductases; C108138:dihydroceramide desaturase; D017855:Transferases (Other Substituted Phosphate Groups); C070186:phosphatidylcholine-ceramide phosphocholine transferase; D013108:Sphingomyelin Phosphodiesterase; D000581:Amidohydrolases; D055572:Ceramidases