title: A rare case of ulcerative colitis complicating Wilson's disease: possible association between the two diseases.
abstract: A case of ulcerative colitis complicated by Wilson's disease is described. In this case, ulcerative colitis occurred 12 years after the diagnosis of Wilson's disease, and the colitis was intractable to prednisolone and salazosulfapyridine. Because copper is one of the trace elements necessary for antioxidant defenses during inflammatory process, altered copper metabolism may have contributed to the intractability of the ulcerative colitis in this case.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. mesaki@intmed2.med.kyushu-u.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Torisu
authors.forename: Motohiro
authors.initials: M
authors.lastname: Esaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Azuma
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Okada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuji
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D003300:Copper / Q000378:metabolism; D006527:Hepatolenticular Degeneration / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine; D003300:Copper; D011239:Prednisolone