title: Analysis of an in vivo assay for inactivated polio vaccine.
abstract: Approaches to the statistical analysis of data from the rat bioassay for Inactivated Polio Vaccine are discussed and compared, using data from a recent collaborative study The measured response, an antibody titre obtained from a doubling dilution series, did not satisfy the requirements of normality and homogeneity of variance necessary for the standard parallel line model for quantitative data. Laboratory-specific cut-offs can be defined, to reduce the data to "positive" or "negative" responses, allowing valid analysis with the probit method.
authors.affiliation: Informatics Laboratory, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK.
authors.forename: A B
authors.initials: AB
authors.lastname: Heath
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology* / Q000592:standards; D051381:Rats; D015203:Reproducibility of Results
chemical_list: D011054:Poliovirus Vaccine, Inactivated