title: Symptom patterns and subgrouping of schizophrenic patients: significance of negative symptoms assessed on admission.
abstract: This study subgroups schizophrenic patients based on symptoms assessed on admission and examines the validity of the subgrouping using follow-up data and other clinical outcome variables. Schizophrenic patients (n=163) from consecutive admission received ratings on the positive and negative syndrome scale (PANSS) on admission and during a 1-year follow-up course. An exploratory graphic analysis on the admission PANSS derived four symptom dimensions: negative symptoms, disorganized thought, hostility/excitement and delusions/hallucinations. This yielded two subgroups of patients on admission, a group with marked negative (GWNEG) and a group without marked negative (GONEG) symptoms. Compared with the GONEG, the GWNEG had a poorer recovery rate, more impairment in attention, a slower response of the delusion/hallucination symptoms to neuroleptic treatment and a longer duration of index hospitalization. At a one-year follow-up, the GWNEG assessed on admission had persistently higher scores on the negative symptom and disorganized thought syndromes, less relapse rate, a shorter duration on job, as well as worse social functioning than the GONEG. Thus, the GONEG might comprise patients having a pure paranoid syndrome with quick and better treatment response, while the GWNEG comprises patients with the blunt-disorganization syndrome having a poorer outcome.
authors.affiliation: Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. haigohgwu@ha.mc.ntu.edu.tw
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
authors.forename: Chun-Houh
authors.initials: CH
authors.lastname: Chen
authors.forename: Tzung-Jeng
authors.initials: TJ
authors.lastname: Hwang
authors.forename: Chih-Min
authors.initials: CM
authors.lastname: Liu
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Cheng
authors.forename: Shi-Kwang
authors.initials: SK
authors.lastname: Lin
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Liu
authors.forename: Chen-Hsin
authors.initials: CH
authors.lastname: Chen
authors.forename: Yueh-Yun
authors.initials: YY
authors.lastname: Chi
authors.forename: Chih-Wen
authors.initials: CW
authors.lastname: Ou-Young
authors.forename: Hsin-Nan
authors.initials: HN
authors.lastname: Lin
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D003863:Depression / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis*; D012565:Schizophrenic Psychology