Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni.
Ecteinascidins 770 (1b) and 786 (3b) were isolated from the pretreated Thai tunicate Ecteinascidia thurstoni with potassium cyanide in buffer solution (pH 7). These structures were fully elucidated by extensive 2D NMR analysis.
Suwanborirux
Khanit
K
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Bangkok 10330, Thailand. Khanit.S@chula.ac.th
Charupant
Kornvika
K
Amnuoypol
Surattana
S
Pummangura
Sunibhond
S
Kubo
Akinori
A
Saito
Naoki
N
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002021:Buffers; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D007546:Isoquinolines; D007624:KB Cells / Q000187:drug effects; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D011190:Potassium Cyanide; D013785:Thailand; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D002021:Buffers; D006576:Heterocyclic Compounds, 4 or More Rings; D007546:Isoquinolines; C464992:ecteinascidin 770; C464993:ecteinascidin 786; D011190:Potassium Cyanide