title: Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma.
abstract: OBJECTIVE
  To review the reliability of computed tomographic (CT) and magnetic resonance (MR) imaging features in distinguishing lipoma and well-differentiated liposarcoma.
  
  
  METHODS
  CT (n= 29) and MR (n = 40) images and radiographs (n = 28) of 60 patients with histologically verified fatty tumors (35 lipomas and 25 well-differentiated liposarcomas) were retrospectively reviewed in 31 females and 29 males (mean age, 56 years; age range, 1-88 years). Images were assessed for adipose tissue content, and non-fatty component was classified (thin and/or thick septa and nodular and/or globular components) as absent, mild, moderate, or pronounced. Also assessed were signal intensity and tissue attenuation of the fatty components and non-adipose elements.
  
  
  RESULTS
  Statistically significant imaging features favoring a diagnosis of liposarcoma included lesion larger than 10 cm (P <.001), presence of thick septa (P =.001), presence of globular and/or nodular non-adipose areas (P =.003) or masses (P =.001), and lesion less than 75% fat (P <.001). The most statistically significant radiologic predictors of malignancy were male sex, presence of thick septa, and associated non-adipose masses, which increased the likelihood of malignancy by 13-, nine-, and 32-fold, respectively. Both lipoma and liposarcoma demonstrated thin septa and regions of increased signal intensity on fluid-sensitive MR images.
  
  
  CONCLUSIONS
  A significant number of lipomas will have prominent non-adipose areas and will demonstrate an imaging appearance traditionally ascribed to well-differentiated liposarcoma. Features that suggest malignancy include increased patient age, large lesion size, presence of thick septa, presence of nodular and/or globular or non-adipose mass-like areas, and decreased percentage of fat composition.
authors.affiliation: Department of Radiology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224-3899, USA. kransdorf.mark@mayo.edu
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kransdorf
authors.forename: Laura W
authors.initials: LW
authors.lastname: Bancroft
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Peterson
authors.forename: Mark D
authors.initials: MD
authors.lastname: Murphey
authors.forename: William C
authors.initials: WC
authors.lastname: Foster
authors.forename: H Thomas
authors.initials: HT
authors.lastname: Temple
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008067:Lipoma / Q000175:diagnosis*; D008080:Liposarcoma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D014057:Tomography, X-Ray Computed