Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins.
This review describes the ionic mechanisms involved in the nodal swelling of frog myelinated axons caused by specific marine neurotoxins (ciguatoxins, brevetoxins, Conus consors toxin and equinatoxin-II), analysed using confocal laser scanning microscopy. We have focussed on toxins that either target neuronal voltage-dependent Na+ channels, or that form cation-selective pores and indirectly affect the functioning of the Na(+)-Ca(++)exchanger.
Benoit
Evelyne
E
Laboratoire de Neurobiologie Cellulaire et Moléculaire, UPR 9040, Institut Fédératif de Neurobiologie Alfred Fessard, CNRS, bat. 32-33, 91198 Gif sur Yvette Cedex, France.
Mattei
Cesar
C
Ouanounou
Gilles
G
Meunier
Frederic A
FA
Suput
Dusan
D
Le Gall
Frederic
F
Marquais
Michel
M
Dechraoui
Marie Y
MY
Molgo
Jordi
J
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D002412:Cations; D002922:Ciguatoxins / Q000494:pharmacology*; D003064:Cnidarian Venoms / Q000494:pharmacology*; D006801:Humans; D007477:Ions; D008387:Marine Toxins / Q000494:pharmacology*; D009498:Neurotoxins / Q000494:pharmacology*; D035964:Oxocins; D011901:Ranvier's Nodes / Q000187:drug effects* / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D000095702:Polyether Toxins
D002412:Cations; D002922:Ciguatoxins; D003064:Cnidarian Venoms; D007477:Ions; D008387:Marine Toxins; D009498:Neurotoxins; D035964:Oxocins; D015222:Sodium Channels; C012307:equinatoxin; C053342:brevetoxin; D000095702:Polyether Toxins