title: Appearance of del(11q) in two patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and combination chemotherapy.
abstract: Two acute promyelocytic leukaemia patients, treated with all-trans retinoic acid and combination chemotherapy, acquired a deletion of 11q within 12 months of diagnosis. One patient died in relapse, with both t(15;17) and del(11q) cell lines co-existing. Patient 2 remains in remission with del(11q) in 70% metaphases, despite normal marrow morphology. No deletion of the MLL gene was identified in the latter patient. The early appearance of a del(11q) is unusual, particularly without morphological evidence of myelodysplasia. We hypothesize that the del(11q) was therapy-induced but the absence of other genetic lesions has resulted in no accompanying morphological changes.
authors.affiliation: Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Melbourne, Australia. campbelj@svhm.org.au
authors.forename: Lynda J
authors.initials: LJ
authors.lastname: Campbell
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Rayeroux
authors.forename: Kathryn
authors.initials: K
authors.lastname: Arkell
authors.forename: John V
authors.initials: JV
authors.lastname: Catalano
authors.forename: Merrole F
authors.initials: MF
authors.lastname: Cole-Sinclair
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin