title: Prediction error variance and expected response to selection, when selection is based on the best predictor - for Gaussian and threshold characters, traits following a Poisson mixed model and survival traits.
abstract: In this paper, we consider selection based on the best predictor of animal additive genetic values in Gaussian linear mixed models, threshold models, Poisson mixed models, and log normal frailty models for survival data (including models with time-dependent covariates with associated fixed or random effects). In the different models, expressions are given (when these can be found - otherwise unbiased estimates are given) for prediction error variance, accuracy of selection and expected response to selection on the additive genetic scale and on the observed scale. The expressions given for non Gaussian traits are generalisations of the well-known formulas for Gaussian traits - and reflect, for Poisson mixed models and frailty models for survival data, the hierarchal structure of the models. In general the ratio of the additive genetic variance to the total variance in the Gaussian part of the model (heritability on the normally distributed level of the model) or a generalised version of heritability plays a central role in these formulas.
authors.affiliation: Department of Animal Breeding and Genetics, Danish Institute of Agricultural Sciences, P.O. Box 50, 8830 Tjele, Denmark. IngeR.Korsgaard@agrsci.dk
authors.forename: Inge Riis
authors.initials: IR
authors.lastname: Korsgaard
authors.forename: Anders Holst
authors.initials: AH
authors.lastname: Andersen
authors.forename: Just
authors.initials: J
authors.lastname: Jensen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001947:Breeding; D016014:Linear Models; D008957:Models, Genetic; D015233:Models, Statistical; D016012:Poisson Distribution; D016016:Proportional Hazards Models; D012641:Selection, Genetic