Analytical methods for the monitoring of solid phase organic synthesis.
Solid phase synthesis (SPS) is a powerful technique to assemble compound libraries in high-throughput parallel and combinatorial synthesis. The widespread applications of these techniques required the development of analytical methods for both structural elucidation and reaction monitoring. This review covers some recently developed techniques for on-bead analyses together with solution-state ones. Particular emphasis is devoted to software and hardware improvements for automated high-throughput analysis.
Dal Cin
M
M
Computational, Analytical and Structural Sciences, GlaxoSmithKline Medicines Research Center, Verona, Italy.
Davalli
S
S
Marchioro
C
C
Passarini
M
M
Perini
O
O
Provera
S
S
Zaramella
A
A
D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002625:Chemistry, Organic / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D019151:Peptide Library
D019151:Peptide Library