Characterization of a Bacillus subtilis thermosensitive teichoic acid-deficient mutant: gene mnaA (yvyH) encodes the UDP-N-acetylglucosamine 2-epimerase.
The Bacillus subtilis thermosensitive mutant ts-21 bears two C-G-->T-A transitions in the mnaA gene. At the nonpermissive temperature it is characterized by coccoid cell morphology and reduced cell wall phosphate content. MnaA converts UDP-N-acetylglucosamine into UDP-N-acetylmannosamine, a precursor of the teichoic acid linkage unit.
Soldo
Blazenka
B
Institut de Génétique et de Biologie Microbiennes, CH-1005 Lausanne, Switzerland.
Lazarevic
Vladimir
V
Pooley
Harold M
HM
Karamata
Dimitri
D
D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism; D002238:Carbohydrate Epimerases / Q000235:genetics* / Q000378:metabolism; D002473:Cell Wall / Q000378:metabolism; D029968:Escherichia coli Proteins; D008969:Molecular Sequence Data; D009154:Mutation; D010710:Phosphates / Q000378:metabolism; D016415:Sequence Alignment; D013682:Teichoic Acids / Q000235:genetics* / Q000378:metabolism; D013696:Temperature
D029968:Escherichia coli Proteins; D010710:Phosphates; D013682:Teichoic Acids; D002238:Carbohydrate Epimerases; C100033:UDP acetylglucosamine-2-epimerase; C083982:wecB protein, E coli