Psychoneuroimmunology: psychological influences on immune function and health.
This review focuses on human psychoneuroimmunology studies published in the past decade. Issues discussed include the routes through which psychological factors influence immune function, how a stressor's duration may influence the changes observed, individual difference variables, the ability of interventions to modulate immune function, and the health consequences of psychosocially mediated immune dysregulation. The importance of negative affect and supportive personal relationships are highlighted. Recent data suggest that immune dysregulation may be one core mechanism for a spectrum of conditions associated with aging, including cardiovascular disease, osteoporosis, arthritis, Type 2 diabetes, certain cancers, and frailty and functional decline; production of proinflammatory cytokines that influence these and other conditions can be stimulated directly by negative emotions and indirectly by prolonged infection.
Kiecolt-Glaser
Janice K
JK
Department of Psychiatry and Institute for Behavioral Medicine Research, Ohio State University College of Medicine, Columbus 43210, USA. kiecolt-glaser.1@osu.edu
McGuire
Lynanne
L
Robles
Theodore F
TF
Glaser
Ronald
R
D006293:Health Promotion; D006304:Health Status; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007378:Interleukins / Q000276:immunology; D011598:Psychoneuroimmunology / Q000379:methods*; D013315:Stress, Psychological / Q000276:immunology
D007378:Interleukins