Pushing the envelope: chromatin boundaries at the nuclear pore.
In a novel genetic screen, the nuclear-cytoplasmic transport system was found to reposition DNA to the nuclear pore and establish a barrier to the spread of heterochromatin. These data provide a mechanism for movement and attachment of DNA to a functional nuclear compartment.
Shinkura
Nobuhiko
N
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Forrester
William C
WC
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D002262:Carboxy-Lyases / Q000235:genetics / Q000378:metabolism; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal / Q000235:genetics; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D022022:Nuclear Pore / Q000378:metabolism*
D004271:DNA, Fungal; D005656:Fungal Proteins; D006570:Heterochromatin; D002262:Carboxy-Lyases; C022378:phosphoribosylaminoimidazole carboxylase