title: Effect of intracavitary injection of urokinase in the experimentally induced early pyogenic liver abscess of the rabbit.
abstract: This study was carried out to assess the effects of intracavitary injection of urokinase in the early liver abscess (ELA) of the rabbits. ELAs were induced on 25 in 47 New Zealand rabbits, which were divided into two groups, with 15 in group A, and 10 in group B. Urokinase was injected into the ELA of group A, and normal physiologic saline into those of group B. One and a half hours after the injections, the rabbits were sacrificed and evaluated by pathologists for the degree of fibrosis of the ELA wall, and fibrinolysis in the ELA itself. Statistical analyses were performed between the two groups. The following ELA sizes for each group were obtained: Group A, 4.3 x 2.9-10.1 x 7.2 mm (mean 7.1 x 4.1 mm); Group B, 4.6 x 2.7-15.0 x 9.7 mm (mean 8.5 x 4.57 mm). Eleven (73%) in group A showed grade II fibrosis of ELA wall, and 8 (80%) in group B showed grade III fibrosis of ELA wall (p=0.002). On pathological analysis, 5 (46%) in group A showed grade II fibrin, and 8 (80%) in group B showed grade III fibrin, of the ELA (p=0.09). In conclusion, injection of urokinase, into the ELAs, can reduce the degree of fibrosis of abscess walls.
authors.affiliation: Department of Surgery, Ansan Hospital, Korea University College of Medicine, #516 Kojan Dong, Ansan City, Kyung Ki Do 425-020, Korea.
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Song
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Cha
authors.forename: Baek Hyun
authors.initials: BH
authors.lastname: Kim
authors.forename: Hwan Hoon
authors.initials: HH
authors.lastname: Chung
authors.forename: Cheol Min
authors.initials: CM
authors.lastname: Park
authors.forename: Jung Hyuck
authors.initials: JH
authors.lastname: Kim
authors.forename: Il-Ok
authors.initials: IO
authors.lastname: Lee
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Lee
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Kim
authors.forename: Daesu
authors.initials: D
authors.lastname: Kim
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Park
authors.forename: Seung-Joo
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Choi
authors.forename: Young Cheol
authors.initials: YC
authors.lastname: Kim
authors.forename: Seong-Ok
authors.initials: SO
authors.lastname: Seo
authors.forename: Bum-Hwan
authors.initials: BH
authors.lastname: Koo
mesh_terms: D000818:Animals; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D005355:Fibrosis; D007267:Injections; D008100:Liver Abscess / Q000188:drug therapy* / Q000473:pathology; D011817:Rabbits; D013492:Suppuration; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D014568:Urokinase-Type Plasminogen Activator