Current strategies of antibody-based treatment in Hodgkin's disease.
Many new approaches involving antibody-based agents have given promising results in experimental Hodgkin's disease (HD) models. Clinical trials with monoclonal antibodies, immunotoxins, bispecific constructs and radioimmunoconjugates have demonstrated some clinical efficacy in patients with advanced refractory HD. Although it seems unlikely that resistant patients with larger tumor masses will be cured by either of these approaches, it might be feasible to treat bulky disease by conventional therapy and then administer biological agents to kill residual Hodgkin and Reed-Sternberg cells. Future phase III trials will have to prove a possible superior effect of this combined immunochemotherapy. Currently, the evaluation of the most promising approaches continues.
Schnell
R
R
Klinik I für Innere Medizin, Universität zu Köln, Germany.
Borchmann
P
P
Schulz
H
H
Engert
A
A
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004167:Diphtheria Toxin / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000276:immunology / Q000628:therapy*; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use; D007167:Immunotherapy; D000922:Immunotoxins / Q000627:therapeutic use; D017730:Ki-1 Antigen / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D016499:Radioimmunotherapy; D012276:Ricin / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D004167:Diphtheria Toxin; D018796:Immunoconjugates; D000922:Immunotoxins; D017730:Ki-1 Antigen; D012276:Ricin