title: Estrogen therapy and noncognitive psychiatric signs and symptoms in elderly patients with dementia.
abstract: OBJECTIVE
  This study investigated the efficacy and safety of short-term estrogen therapy in decreasing noncognitive signs and symptoms of dementia in demented elderly patients.
  
  
  METHODS
  Sixteen moderately to severely demented elderly patients with aggressive behavioral disturbances were randomly assigned to receive conjugated equine estrogens or placebo in a 4-week clinical trial. Frequency and severity of noncognitive signs and symptoms of dementia, as assessed with the Dementia Signs and Symptoms Scale, were compared between estrogen and placebo groups. Data were analyzed with intent-to-treat and regression modeling methods.
  
  
  RESULTS
  Estrogen therapy was associated with a significantly greater improvement on the Dementia Signs and Symptoms Scale total score than placebo. All five Dementia Signs and Symptoms Scale subscale comparisons favored estrogen therapy. No adverse effects were observed.
  
  
  CONCLUSIONS
  These preliminary data suggest that short-term estrogen therapy may safely decrease the frequency and severity of noncognitive signs and symptoms of dementia in elderly patients.
authors.affiliation: McLean Hospital, 115 Mill Street, Belmont, MA 02478-9106, USA. helen_kyomen@hms.harvard.edu
authors.forename: Helen H
authors.initials: HH
authors.lastname: Kyomen
authors.forename: John
authors.initials: J
authors.lastname: Hennen
authors.forename: Gary L
authors.initials: GL
authors.lastname: Gottlieb
authors.forename: Jeanne Y
authors.initials: JY
authors.lastname: Wei
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000374:Aggression / Q000523:psychology; D015897:Comorbidity; D003704:Dementia / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D004966:Estrogens, Conjugated (USP); D010919:Placebos