[Biologic properties of lipoic acid].
Lipoic acid is a prostetic group of H-protein of the glycine cleavage system and the dihydrolipoamide acyltransferases (E2) of the pyruvate, alpha-ketoglutarate and branched-chain alpha-keto acid dehydrogenase complexes. Lipoic acid and its reduced form, dihydrolipoic acid, reacts with oxygen reactive species. This paper reviews the beneficial effects in oxidative stress models or clinical conditions.
Bilska
Anna
A
Instytut Biochemii Lekarskiej Collegium Medicum Uniwersytetu Jagiellońskiego, Krakowie. mbbilska@cyf-kr.edu.pl
Włodek
Lidia
L
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000375:Aging / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002386:Cataract / Q000188:drug therapy; D003653:Decarboxylation; D003925:Diabetic Angiopathies / Q000188:drug therapy; D003929:Diabetic Neuropathies / Q000188:drug therapy; D005998:Glycine / Q000378:metabolism; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy; D008670:Metals / Q000506:poisoning; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D018384:Oxidative Stress / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology; D008063:Thioctic Acid / Q000378:metabolism* / Q000627:therapeutic use
D000975:Antioxidants; D008670:Metals; D008063:Thioctic Acid; D005998:Glycine