A matter of life and death.
We propose that deregulation of proliferation, together with a reduction in apoptosis, creates a platform that is both necessary and can be sufficient for cancer. The secondary traits of diverse neoplasms are a consequence of cell proliferation, tissue expansion, and other outcomes of this platform.
Green
Douglas R
DR
La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA.
Evan
Gerard I
GI
D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D002470:Cell Survival; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction