title: Ameloblastoma in children.
abstract: OBJECTIVE
  The purpose of this report was 1) to report the experience of the University of Maryland, Department of Oral and Maxillofacial Surgery (OMS Department) in the treatment of ameloblastoma in children and 2) to review the world literature on the treatment of ameloblastoma in children from 1970 to 2001.
  
  
  METHODS
  This study first reviews the experience of the OMS Department of the University of Maryland with ameloblastomas in children and then reviews the literature on this subject. The first part of the study was undertaken by a retrospective chart review of all patients with a diagnosis of ameloblastoma in the OMS Department between May 1991 and December 1999. The literature on ameloblastoma in Western societies and Africa was separately reviewed from 1970 through 2001. Reports earlier than 1970 were not reviewed, as the histologic diagnosis of ameloblastoma was not well defined before that period.
  
  
  RESULTS
  In the Maryland series, 11 patients under the age of 20 years with ameloblastoma were treated. Eight patients were seen primarily, and 3 presented with recurrent lesions. The average age was 15.5 years; 5 of 11 patients were black, and 9 of 11 tumors were unicystic ameloblastomas. The literature review showed 85 children in the Western reports and 77 reported from Africa. The average ages were 14.3 and 14.7 years, respectively, but unicystic ameloblastomas accounted for 76.5% of the Western and only 19.5% of the African children, with an increased frequency of occurrence in the mandibular symphisis in African (44.2%) versus Western (5.8%) patients. Analysis of recurrence after enucleation of unicystic ameloblastomas in 20 children followed at least 5 years or until recurrence showed a recurrence of 40%.
  
  
  CONCLUSIONS
  Ameloblastomas in children differ from adults, with a higher percentage of unicystic tumors. African children appear to resemble the adult pattern. Although enucleation has been claimed to give acceptable recurrence rates in unicystic ameloblastoma, there are no large series with long follow-up in children. The histologic pattern that exhibits mural invasion in unicystic ameloblastoma suggests that more aggressive surgery is necessary.
authors.affiliation: Oral and Maxillofacial Surgery, Baltimore College of Dental Surgery, University of Maryland Medical Systems, Baltimore, MD, USA. rord@umm.edu
authors.forename: R A
authors.initials: RA
authors.lastname: Ord
authors.forename: R H
authors.initials: RH
authors.lastname: Blanchaert
authors.forename: N G
authors.initials: NG
authors.lastname: Nikitakis
authors.forename: J J
authors.initials: JJ
authors.lastname: Sauk
mesh_terms: D000293:Adolescent; D000328:Adult; D000349:Africa / Q000453:epidemiology; D000367:Age Factors; D000564:Ameloblastoma / Q000145:classification / Q000453:epidemiology* / Q000601:surgery; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000453:epidemiology*; D008396:Maryland / Q000453:epidemiology; D008441:Maxillary Neoplasms / Q000453:epidemiology*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D044469:Racial Groups; D012189:Retrospective Studies; D019366:Western World