title: Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma.
abstract: Non-neuroadapted influenza virus confined to the brain parenchyma does not induce antigen-specific immunity. Nevertheless, infection in this site upregulated major histocompatibility complex (MHC) class I and MHC class II expression and recruited lymphocytes to a perivascular compartment. T cells recovered from the brain had an activated/memory phenotype but did not respond to viral antigens. In contrast, T cells recovered from the brain after infection in a lateral cerebral ventricle, which is immunogenic, showed virus-specific responses. As with infectious virus, influenza virus-infected dendritic cells elicited virus-specific immunity when inoculated into the cerebrospinal fluid but not when inoculated into the brain parenchyma. Thus, inflammation and dendritic cell function were both uncoupled from immune priming in the microenvironment of the brain parenchyma and neither was sufficient to overcome immunological privilege.
authors.affiliation: Nuffield Department of Medicine1 and Nuffield Department of Surgery2, John Radcliffe Hospital, Oxford, UK.
authors.forename: P G
authors.initials: PG
authors.lastname: Stevenson
authors.affiliation: Nuffield Department of Medicine1 and Nuffield Department of Surgery2, John Radcliffe Hospital, Oxford, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Austyn
authors.affiliation: Nuffield Department of Medicine1 and Nuffield Department of Surgery2, John Radcliffe Hospital, Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Hawke
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D001921:Brain / Q000098:blood supply / Q000276:immunology / Q000821:virology*; D002552:Cerebral Ventricles / Q000821:virology; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D007249:Inflammation / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009975:Orthomyxoviridae / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000821:virology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD