Synthesis and DNA-binding properties of cationic 2,2':6',2' '-terpyridineplatinum(II) complexes containing 1,2- and 1,7-dicarba-closo-dodecaborane(12).
The first examples of DNA metallointercalators containing a dicarba-closo-dodecaborane(12) (carborane) moiety are presented. Treatment of the labile platinum(II) complex [Pt(OTf)(terpy)](+) (terpy = 2,2':6',2' '-terpyridine) with the 1,2-carborane monothiol derivatives 1-HS(CH(2))(n)-1,2-C(2)B(10)H(11) (n = 0, 1) or the novel 1,7-carborane ligand, 1-HSCH(2)-1,7-C(2)B(10)H(11), affords the stable, brightly colored species [Pt(1-S(CH(2))(n)-1,Z-C(2)B(10)H(11))(terpy)](+) (Z = 2, n = 0, 1; Z = 7, n = 1) in good yield and purity. Preliminary DNA-binding experiments with calf-thymus DNA indicate an intercalative interaction by the platinum(II) complexes at high r(f) values.
Todd
Jean A
JA
Department of Chemistry, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Rendina
Louis M
LM
D000818:Animals; D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism*; D016754:Boron Neutron Capture Therapy; D002417:Cattle; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000378:metabolism*; D013950:Thymus Gland; D015032:Zinc / Q000737:chemistry
D001896:Boron Compounds; D003432:Cross-Linking Reagents; D009944:Organoplatinum Compounds; D004247:DNA; D015032:Zinc