[Expression of WT1 gene mRNA in leukemia].
WT1 gene expression was determined in acute leukemic patients by RT-PCR.


RESULTS
19 patients were found to have positive results among 28 patients, the positive rate is 67.9%, and in 16 ANLL patients, 11 cases got positive results, in 12 ALL patients, 8 cases got positive results. It suggested that WT1 was highly expressed in acute leukemia. It is a new and significant detective marker for monitoring the effect of chemotherapy, predicting the prognosis and in the research of minimal residual disease (MRD).
Jian
Z
Z
Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Chen
F
F
Xie
Q
Q
Liu
W
W
Zhong
M
M
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D016162:Genes, Wilms Tumor; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D025721:WT1 Proteins / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D025721:WT1 Proteins