Histone variants and nucleosome deposition pathways.
In this issue of Molecular Cell, Ahmad and Henikoff show that the replication-independent pathway of chromatin assembly in vivo can discriminate between different histone variants on the basis of their primary amino acid sequences. These results have important implications for chromatin remodeling and epigenetic imprinting.
Smith
M Mitchell
MM
Department of Microbiology and University of Virginia Cancer Center, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, VA 22901, USA.
D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D009707:Nucleosomes / Q000378:metabolism*; D017434:Protein Structure, Tertiary
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes