Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.
Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl chloride (PC)-induced contact dermatitis in experimental animals. CM-ext showed inhibitory effects on these allergic models. Osthol isolated from CM-ext also had the inhibitory effects. These results suggested that Cnidii Monnieri Fructus might be useful as an agent for allergic diseases and that its anti-allergic effect was partially attributable to a coumarin derivative, osthol.
Matsuda
Hideaki
H
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan. matsuda@phar.kindai.ac.jp
Tomohiro
Norimichi
N
Ido
Yasuko
Y
Kubo
Michinori
M
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D031048:Cnidium / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000473:pathology / Q000517:prevention & control; D004139:Dinitrofluorobenzene / Q000037:antagonists & inhibitors / Q000633:toxicity; D004155:Diphenhydramine / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010853:Picryl Chloride / Q000037:antagonists & inhibitors / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D011537:Pruritus / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology
D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D010936:Plant Extracts; D004155:Diphenhydramine; D011239:Prednisolone; D004139:Dinitrofluorobenzene; C046627:osthol; D010853:Picryl Chloride