Lactic acidosis and abnormal liver function in advanced HIV disease.
A 48 year old man receiving HAART presented with late stage HIV disease, non-specific symptoms, a normal sized liver, ascites, and lactic acidosis. Following a failed liver biopsy worsening acidosis developed, requiring ICU support. Progressive liver failure occurred. Endoscopy showed oesophageal varices and a transjugular liver biopsy showed non-cirrhotic cholestasis; findings that were ascribed to HAART.
Shahmanesh
M
M
Department of Genito-Urinary Medicine, Mortimer Market Centre, Camden and Islington Community Health Services NHS Trust, London, UK.
Cartledge
J
J
Miller
R
R
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged