Mice that are congenic for the char2 locus are susceptible to malaria.
A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.
Burt
Rachel A
RA
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia.
Marshall
Vikki M
VM
Wagglen
Jamie
J
Rodda
Fleur R
FR
Senyschen
Danielle
D
Baldwin
Tracey M
TM
Buckingham
Lynn A
LA
Foote
Simon J
SJ
D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D008288:Malaria / Q000235:genetics*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D019655:Quantitative Trait, Heritable