Local injection of botulinum toxin type A for hemifacial spasm.
The preliminary experience of botulinum toxin treatment for hemifacial spasm is reported in this study. Five patients were treated with 10 injections of botulinum toxin in total. Botulinum toxin had a good to excellent effect in all cases. Improvement was observed 2 weeks to 1 month after the injection. The duration of improvement was 0-9 months (mean 4.2 months). The peak rank tended to decrease and the duration of improvement increased after several treatments. Hemifacial spasm caused by the anterior inferior cerebellar artery tended to subside easily. In contrast, compression by the vertebral artery was more refractory. Continuous facial spasm caused by operative trauma subsided after the injection, but paroxysmal spasm still occurred when eating or laughing. Spasm caused by trauma disappeared 4.5 months after the injection. The complications, which were facial nerve paresis in two cases (3 injections, 30%) and diplopia in one case (1 injection, 10%), were transient and subsided in 2 weeks.
Oyama
Hirofumi
H
Department of Neurosurgery, Chukyo Hospital, Nagoya.
Ikeda
Akira
A
Inoue
Shigeo
S
Nakashima
Yasuhiro
Y
Shibuya
Masato
M
D000063:Accidents, Traffic; D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D019299:Decompression, Surgical; D004341:Drug Evaluation; D020220:Facial Nerve Injuries / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D019569:Hemifacial Spasm / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007267:Injections; D007431:Intraoperative Complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000188:drug therapy / Q000209:etiology; D009464:Neuroma, Acoustic / Q000601:surgery; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014711:Vertebral Artery / Q000473:pathology
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A