The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats.
We examined if thrombin or a receptor-activating peptide for protease-activated receptor-1 (PAR-1), a thrombin receptor, could modulate nociception at peripheral levels. Intraplantar administration of PAR-1 activators, thrombin or TFLLR-NH(2), but not its inactive control FTLLR-NH(2) or a PAR-2 activator SLIGRL-NH(2), significantly attenuated the hyperalgesia in rats treated with carrageenan, although they had no effect on nociception in naïve rats. The thrombin-PAR-1 system might thus act to attenuate nociception during inflammatory hyperalgesia.
Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, 577-8502, Higashi-Osaka, Japan. kawabaa@phar.kindai.ac.jp
Atsufumi
A
Kawabata
Naoyuki
N
Kawao
Ryotaro
R
Kuroda
Atsuko
A
Tanaka
Chiho
C
Shimada
D000818:Animals; D002351:Carrageenan / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D010146:Pain; D051381:Rats; D017208:Rats, Wistar; D013917:Thrombin / Q000378:metabolism; D013997:Time Factors
D009842:Oligopeptides; C462999:PAR-1-activating peptide; C112356:seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide; D002351:Carrageenan; D013917:Thrombin