Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols.
The in vitro antifungal activity of a series of alpha,omega-bifunctionalized aminoalcohols against Candida glabrata was measured. The dimeric bi-functionalized lipids exhibited activity about approximately 10-fold higher higher than D-sphingosine, which is a larger factor than expected from the simple additive effects of vicinal aminoalcohols groups.
Department of Chemistry, University of California, Davis, CA 95616, USA.
Gillian M
GM
Nicholas
Ronghua
R
Li
John B
JB
MacMillan
Tadeusz F
TF
Molinski
D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D041221:Candida glabrata / Q000187:drug effects; D006017:Glycolipids / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013107:Sphingolipids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000605:Amino Alcohols; D000935:Antifungal Agents; D006017:Glycolipids; D013107:Sphingolipids; C404387:oceanapiside