Mass spectrometric characterization of substituted 2-thiazolin-4-one derivatives.
Electron ionization mass spectrometry was used for the structural characterization of substituted 2-thiazolin-4-one derivatives in the gas phase. The compounds follow common fragmentation pathways, producing ions whose abundances are dependent on the chemical nature of the substituent at position 2. Collision-induced dissociation tandem mass spectrometric experiments, carried out on both molecular ions and fragment ions produced in the source, allowed the elucidation of gas-phase decompositions. The presence of tautomeric forms is suggested for some ionic species. Rapid identification of a primary or secondary amine moiety at position 2 of the thiazoline ring can be achieved by the detection of characteristic fragmentations occurring both in the ion source and under the collision-induced dissociation regime.
Dipartimento di Chimica e Centro Interdipartimentale di Analisi e Determinazioni Strutturali, Università degli Studi di Siena, via Aldo Moro, 53100 Siena, Italy. gianluca.giorgi@unisi.it
Gianluca
G
Giorgi
Laura
L
Salvini
Orazio A
OA
Attanasi
Paolino
P
Filippone
Stefania
S
Santeusanio
D002412:Cations / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization; D013844:Thiazoles / Q000737:chemistry*
D002412:Cations; D005609:Free Radicals; D010972:Platelet Activating Factor; D013844:Thiazoles