[Relationship between calpain-10 gene polymorphism, hypertension and plasma glucose].
OBJECTIVE
To detect the association among calpain-10(CAPN-10) gene polymorphism, hypentension and hyperglycemia.


METHODS
378 individuals in the present study were the second generation offsprings of 187 hypentensives and 19 1 nonhypertensives. Fasting plasma glucose (FPG), insulin, triglyceride and fibrinogen were determined. The polymorphism of UCSNP-43 and UCSNP-44 of CAPN 10 gene were analysed with PCR-SSCP method.


RESULTS
(1)The frequency of G/G geno type of UCSNP-43 was higher in the second generation offsprings of the hypertensives than that in the nonhypertensive controls(86.6%, 75.4%, P < 0.05). (2) The frequenncy of G/G genotype of UCSNP-43 was higher in the hypertensive parents of the second generation offsprings in the hypertensive groups than that in the normotensive parent of the second generation offsprings of the nonhypertensive control groups (OR = 2.84, P = 0.01). After adjustment of age, sex and body mass index (BMI), the frequency of G/G genotype in the highest FPG-quartiles (FPG 5.42 +/- 0.1mmol/L) was much more than that in the lowest FPG quartiles (FPG 4.09 +/- 0.3 mmol/L) with OR of 3.32.


CONCLUSIONS
Polymorphism of UCSNP-43 in CAPN-10 gene might be one of the genetic factors contributing to hypertension and diabetes mellitus in the population in Daqing city. It may be a predictor of type 2 diabetes mellitus (T2DM) in the decendents of hypertensives.
Hong
Jing
J
Department of Endocrinology, China-Japan Friendship Hospital,Beijing 100029, China.
Li
Guangwei
G
Li
Chunmei
C
Hui
Rutai
R
Sun
Shuxiang
S
Wang
Jizheng
J
Ye
Jue
J
Cai
Hui
H
D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis*; D002154:Calpain / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D006973:Hypertension / Q000235:genetics*; D007328:Insulin / Q000097:blood; D008297:Male; D011110:Polymorphism, Genetic; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D005340:Fibrinogen; D002154:Calpain; C415197:calpain 10