Quantitation of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by solid-phase microextraction coupled with electrospray ionization-high-field asymmetric waveform ion mobility spectrometry-mass spectrometry.
Amphetamine, methamphetamine, and their methylenedioxy derivatives have been identified and measured in a human urine matrix using solid-phase microextraction (SPME) and high-field asymmetric waveform ion mobility spectrometry (FAIMS) in combination with electrospray ionization (ESI) and mass spectrometric detection (MS). Limits of detection in human urine between 200 pg/mL and 7.5 ng/mL have been achieved. The use of a simple extraction method, SPME, combined with the high sensitivity and selectivity of ESI-FAIMS-MS eliminates the need for chromatographic separation and allows for very rapid sample processing.
Institute for National Measurement Standards, National Research Council of Canada, Ottawa, ON.
Margaret A
MA
McCooeye
Zoltán
Z
Mester
Barbara
B
Ells
David A
DA
Barnett
Randy W
RW
Purves
Roger
R
Guevremont
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000652:urine; D000661:Amphetamine / Q000652:urine*; D000697:Central Nervous System Stimulants / Q000652:urine*; D006213:Hallucinogens / Q000652:urine; D006801:Humans; D007202:Indicators and Reagents; D008694:Methamphetamine / Q000652:urine*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000652:urine; D021241:Spectrometry, Mass, Electrospray Ionization; D015813:Substance Abuse Detection / Q000379:methods*
D000697:Central Nervous System Stimulants; D006213:Hallucinogens; D007202:Indicators and Reagents; D008694:Methamphetamine; D015104:3,4-Methylenedioxyamphetamine; D000661:Amphetamine; D018817:N-Methyl-3,4-methylenedioxyamphetamine; C051800:3,4-methylenedioxyethamphetamine