Painful cutaneous lesions, renal failure and urgent parathyroidectomy.
We describe two patients with end stage renal failure who presented with painful skin lesions, which rapidly progressed to become necrotic and gangrenous. The diagnosis was calciphylaxis, a rare disorder due to calcification and luminal fibrosis of small and medium sized cutaneous and systemic vessels. Both patients had tertiary hyperparathyroidism. An urgent parathyroidectomy was performed on one patient, which relieved her symptoms; the other required local surgery but refused parathyroidectomy and died.
Younis
Naveed
N
Department of Medicine, Royal Liverpool University Hospital, UK. naveedy@tinyonline.co.uk
Sells
Robert A
RA
Desmond
Anthony
A
Helliwell
Timothy
T
Guerin
Deirdre
D
Jibani
Mahdi
M
Vora
Jiten
J
D002115:Calciphylaxis / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D016105:Parathyroidectomy; D012883:Skin Ulcer / Q000209:etiology* / Q000473:pathology / Q000601:surgery*