The effect of propofol on airway pressures generated by magnetic stimulation of the phrenic nerves.
OBJECTIVE
To assess the effect of propofol on the change in airway pressure produced by diaphragmatic contraction.


METHODS
Prospective, controlled study in patients anaesthetised with propofol in a university hospital.


METHODS
We stimulated the phrenic nerves before and immediately after induction of anaesthesia in 11 subjects, using a pair of 43-mm mean diameter double magnetic coils and measured the change in airway pressure at the mouth (TwPmo) produced by the resulting diaphragmatic contraction. Supramaximality of stimulation was confirmed with electromyogram and pressure measurements. We recorded the change in Resting End Expiratory Position (REEP) using a spirometer. We applied an approximate correction for the effect of lung volume on the amplitude of twitch pressure produced by diaphragmatic contraction.


METHODS
Following the initial stimulations, the patients were anaesthetised with a propofol infusion. Once stable, repeat measurements were made.


RESULTS
Following induction, REEP fell by mean 0.3 l standard deviation (SD) 0.2 l. TwPmo fell by mean 14.2% SD 14.0% ( P = 0.01), mean 22.3% SD 11.7% corrected ( P < 0.001). Twitch transdiaphragmatic pressure fell by 18.1% and 20.0% (25.8% and 27.7% corrected) in two further subjects studied with oesophageal and gastric balloon catheters.


CONCLUSIONS
Propofol does reduce the effectiveness with which diaphragmatic contraction produces changes of pressure in the airway.
The University Department of Surgical and Anaesthetic Sciences, Department of Anaesthesia, K Floor, The Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.
I C
IC
Shaw
G H
GH
Mills
D
D
Turnbull
D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D003964:Diaphragm / Q000294:innervation*; D005260:Female; D006801:Humans; D008280:Magnetics / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010791:Phrenic Nerve / Q000187:drug effects*; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D006113:United Kingdom
D018686:Anesthetics, Intravenous; D015742:Propofol