Antimalarial compounds from Parinari capensis.
The antimalarial activity of the raw petroleum ether and dichloromethane extracts of the stems of Parinari capensis (Chrysobalanceae) was determined. Phytochemical investigation of these extracts led to the isolation of three diterpene lactones that possess antimalarial activity with IC(50) values of 0.54, 0.67, and 1.57 microg/mL. Although their antimalarial activity is promising, the toxicity profiles of these diterpene lactones prevent further biological evaluation. They could however be used effectively as lead compounds in the synthesis of novel antimalarial agents.
Uys
Arina C U
AC
Pharmaceutical Chemistry, School of Pharmacy, Potchefstroom University for Christian Higher Education, Private Bag X6001, 2520, Potchefstroom, South Africa.
Malan
Sarel F
SF
van Dyk
Sandra
S
van Zyl
Robyn L
RL
D000818:Animals; D000962:Antimalarials / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004224:Diterpenes / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D007668:Kidney / Q000166:cytology; D007783:Lactones / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D019685:Rosales / Q000737:chemistry*
D000962:Antimalarials; D004224:Diterpenes; D007783:Lactones; D010936:Plant Extracts