Femoral head vascularisation in Legg-Calvé-Perthes disease: comparison of dynamic gadolinium-enhanced subtraction MRI with bone scintigraphy.
BACKGROUND
It has been reported that MRI using a dynamic gadolinium-enhanced subtraction technique can allow the early identification of ischaemia and the pattern of revascularisation in Legg-Calvé-Perthes (LCP) disease with increased spatial and contrast resolution. Therefore, dynamic gadolinium-enhanced subtraction (DGS) MRI may be a possible non-ionising substitute for bone scintigraphy.


OBJECTIVE
The purpose of this prospective study was to compare DGS MRI and bone scintigraphy in the assessment of femoral head perfusion in LCP disease.


METHODS
Twenty-six DGS MR images and bone scintigraphies of 25 hips in 23 children were obtained at different stages of LCP disease; three stage I, 12 stage II, six stage III and five stage IV (Waldenström classification). The extent of necrosis, epiphyseal revascularisation pathways (lateral pillar, medial pillar, and/or transphyseal perfusion) and metaphyseal changes were analysed.


RESULTS
Total agreement between both techniques was noted in the depiction of epiphyseal necrosis (kappa=1), and metaphyseal abnormalities (kappa=0.9). DGS MRI demonstrated better revascularisation in the lateral (kappa=0.62) and medial pillars (kappa=0.52). The presence of basal transphyseal reperfusion was more conspicuous with MRI.


CONCLUSIONS
DGS MRI allows early detection of epiphyseal ischaemia and accurate analysis of the different revascularisation patterns. These changes are directly related to the prognosis of LCP disease and can aid therapeutic decision making.
Department of Paediatric Radiology, Hôpital Robert Debré, 48 boulevard Sérurier, 75935 Paris Cedex, France.
Sylvie
S
Lamer
Sophie
S
Dorgeret
Abdeslam
A
Khairouni
Keyvan
K
Mazda
Pierre-Yves
PY
Brillet
Eric
E
Bacheville
Juliette
J
Bloch
Georges F
GF
Penneçot
Max
M
Hassan
Guy H
GH
Sebag
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005270:Femur Head / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D013382:Subtraction Technique
D009942:Organometallic Compounds; C051342:gadolinium 1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid