Nonsurgical management of gallbladder cancer: cytotoxic treatment and radiotherapy.
Carcinoma of the gallbladder is a rare tumor entity. Apart from surgical intervention, there is no therapeutic measure with curative potential. Therefore, patients with advanced--i.e., unresectable or metastatic-disease present a difficult problem to clinicians, whether to choose a strictly symptomatic treatment or expose the patient to the side effects of potentially ineffective treatment. Despite anecdotal reports about symptomatic palliation and survival advantages, only unrandomized Phase II studies too small to draw meaningful conclusions have been published thus far. Since there is no standard therapy for advanced gallbladder cancer, patients should be offered the opportunity to participate in controlled clinical trials.
Hejna
M
M
Department of Medicine 1, Division of Oncology, University Hospital, 18-20 Waebringer Guertel, A-1090 Vienna, Austria.
Zielinski
C C
CC
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018849:Controlled Clinical Trials as Topic; D005706:Gallbladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D009367:Neoplasm Staging; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant