Tributylphosphine: a remarkable promoting reagent for the ring-opening reaction of aziridines.
Tributylphosphine was found to be an effective promoting reagent for ring opening of a variety of aziridines and nucleophiles to produce anti-bifunctional products in good to excellent yield. The study showed that the reaction is initiated through the attack of tributylphosphine as a nucleophile at the carbon atom of the aziridine ring.
Hou
Xue-Long
XL
Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis and State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, China. xlhou@pub.sioc.ac.cn
Fan
Ren-Hua
RH
Dai
Li-Xin
LX