Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates.
A novel dendritic molecule with nine chlorambucil (CBL) residues on the surface and a maleimide moiety at the core terminus was synthesized using a convergent synthetic methodology. This molecule is ready for attachment to single-chain Fv antibodies (scFvs) to form antibody-multidrug immunoconjugates in an effort to study the relevance of drug/antibody molar ratio and the potency of these drug-antibody immunoconjugates. A monomer and a trimer with a similar structural motif were also prepared for comparative purposes.
Department of Chemistry, The Scripps Research Institute and the Skaggs Institute for Chemical Biology, 10550N. Torrey Pines Road, La Jolla, CA 92037, USA.
Chengzao
C
Sun
Peter
P
Wirsching
Kim D
KD
Janda
D000906:Antibodies / Q000737:chemistry* / Q000276:immunology; D002699:Chlorambucil / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D018796:Immunoconjugates / Q000737:chemistry*; D015394:Molecular Structure
D000906:Antibodies; D018796:Immunoconjugates; D002699:Chlorambucil