New perspectives for tumor pathology provided by comparative genomic hybridization.
Comparative genomic hybridization (CGH) allows rapid screening for DNA copy number gains and losses across the entire genome. CGH analyses have revealed a number of common aberrations and characteristics associated with specific tumor cells or pathogeneses. Recurrent aberrations suggest that tumor-related gene(s) may be located in such regions. Furthermore, some specific aberrations may serve as novel diagnostic features. Quantitative chromosomal analyses based on CGH have also provided stimulating information associated with chromosomal instability, genetic pathways, telomerase activity status, and DNA ploidy and have yielded valuable insights into tumor pathology. This review focuses on scientific advances facilitated by this technique.
Department of Pathology, Yamaguchi University School of Medicine, Ube, Japan. oga@po.cc.yamaguchi-u.ac.jp
Atsunori
A
Oga
Shigeto
S
Kawauchi
Hideki
H
Izumi
Liu Xiu
LX
Ping
Tomoko
T
Furuya
Kohsuke
K
Sasaki
D002874:Chromosome Mapping / Q000379:methods; D004273:DNA, Neoplasm / Q000032:analysis*; D005784:Gene Amplification; D016678:Genome; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009693:Nucleic Acid Hybridization / Q000379:methods*
D004273:DNA, Neoplasm