Apolipoprotein E epsilon 4 allele is not associated with the cognitive impairment in community-dwelling normal elderly individuals.
OBJECTIVE
The aim of this study was to examine whether the APOE epsilon 4 allele also confers a risk for the cognitive impairment in normal aging.


METHODS
We administered all the eight neuropsychological tests from the CERAD neuropsychological battery to the CVD-free, community-dwelling normal elderly individuals, and compared their performance by the occurrence of the APOE epsilon 4 allele.


RESULTS
Either the impact of APOE epsilon 4 allele itself or its interaction terms with age and gender of the subjects did not influence the performance of the eight neuropsychological tests (epsilon p > 0.1 by ANCOVA).


CONCLUSIONS
The APOE epsilon 4 allele is not a risk factor for the cognitive decline in normal elderly individuals regardless of age and gender.
Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Kyunggido, Korea.
K W
KW
Kim
J C
JC
Youn
J H
JH
Jhoo
D Y
DY
Lee
K U
KU
Lee
J H
JH
Lee
J I
JI
Woo
D000368:Aged; D000375:Aging / Q000235:genetics*; D000704:Analysis of Variance; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D003072:Cognition Disorders / Q000453:epidemiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E