Massive bleeding on a bladder protectant: a case report of pentosan polysulfate sodium-induced coagulopathy.
Pentosan polysulfate sodium (Elmiron; Alza Pharmaceuticals, Mountain View, Calif) is an oral preparation of pentosan polysulfate used in the symptomatic management of interstitial cystitis. While pentosan polysulfate has a known heparin-like effect in its parenteral form, there have been no previous reports of coagulopathy with oral use. We present an interesting case of inadvertent systemic anticoagulation resulting in serious bleeding complications in a young woman taking oral pentosan polysulfate for interstitial cystitis.
Department of Medicine, University of British Columbia, Vancouver, Canada.
Sharlene
S
Gill
Sheldon C
SC
Naiman
Abeed
A
Jamal
Linda M
LM
Vickars
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D018856:Cystitis, Interstitial / Q000150:complications* / Q000188:drug therapy*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D005260:Female; D006801:Humans; D010426:Pentosan Sulfuric Polyester / Q000009:adverse effects; D017211:Treatment Failure
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010426:Pentosan Sulfuric Polyester