[Association between pre-excitation syndrome and 7q3 D7S505 pseudonym gene].
OBJECTIVE
Pre-excitation syndrome is considered to be autosomal dominant hereditary disease. The objective of this study was to search the genetic foundation of the pre-excitation syndrome.


METHODS
Genomic DNA was isolated from peripheral lymphocytes obtained from 44 cases of patients with pre-excitation syndrome and 53 normal persons. Polymorphic short tandem repeats(STR) were amplified using polymerase chain reaction (PCR) and analyzed by polyacrylamide gel electrophoresis. The genotype of each individual was determined by polymorphic STR including D7S505,D7S688,D7S483. Association analysis between the pre-excitation syndrome and the 3 STR (D7S505,D7S483 and D7S688) was tested by genotyping.


RESULTS
The relative risk(RR) of alleles A2 A3 A4 and A6 of D7S505 were 1.051 6, 3.432,1.563 1 and 1.714 3 respectively all of which were more than 1, but only the RR of A3 had statistic significant difference, P < 0.05 after tested by kappa(2). It supposed that the distribution of allele A3(266 bp) of D7S505 in patients with pre-excitation syndrome was much higher than that in normal controls, which suggested that pre-excitation syndrome is associated with D7S505. Whereas, there were no significant difference in every allele of D7S483 between the pre-excitation syndrome and normal persons, which suggested that pre-excitation syndrome is not associated with D7S483.


CONCLUSIONS
The pre-excitation syndrome is associated with D7S505,the result is the foundation of the molecular genetics of the disease.
Department of Cardiology, General Army Hospital, Beijing 100853, China.
Wenling
W
Liu
Guoshu
G
Liu
Dayi
D
Hu
Yu
Y
Qi
Zhaoliang
Z
Shan
Leiming
L
Luo
Minghua
M
Zhang
Li
L
Wang
Jun
J
Yi
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002897:Chromosomes, Human, Pair 7; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011226:Pre-Excitation Syndromes / Q000235:genetics*; D020080:Tandem Repeat Sequences