Promotion of cyclization of linear pentapeptides and heptapeptide by different univalent metal ions.
Univalent metal ions such as Na+, K+ and Cs+ can enhance not only the cyclization yields of some linear pentapeptides and heptapeptide but also their cyclization rates while some bivalent and trivalent metal ions such as Mg2+, Ca2+, Zn2+, Fe2+, Ni2+ and Cr3+ elevate neither the cyclization yields nor the cyclization rates and some of them prevent the cyclization.
Ye
Yun-hua
YH
Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Department of Chemistry, Peking University, Beijing 100871, China. yhye@pku.edu.cn
Liu
Mian
M
Tang
Yan-chun
YC
Jiang
Xiaohui
X
D002414:Cations, Monovalent / Q000494:pharmacology; D003500:Cyclization / Q000187:drug effects; D008670:Metals / Q000494:pharmacology*; D009842:Oligopeptides / Q000737:chemistry / Q000187:drug effects; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
D002414:Cations, Monovalent; D008670:Metals; D009842:Oligopeptides; D010456:Peptides, Cyclic