Optimisation of a programmed split-splitless injector in the gas chromatographic-mass spectrometric determination of organochlorine pesticides.
Large-volume injection techniques in gas chromatography are used to compensate for the at times limited detection sensitivity of mass spectrometric detection. In this work a programmed split-splitless injector in solvent split mode was employed to determine organochlorine pesticides in environmental samples. The injection conditions were selected by a Plackett-Burman design followed by a central composite design. The LODs obtained in the optimum conditions were compared with those obtained with splitless-MS and splitless-ECD. Finally, the method was applied to a soil sample.
Concha-Graña
E
E
Department of Analytical Chemistry, Faculty of Sciences, University of A Coruña, Spain.
Turnes-Carou
M I
MI
Muniategui-Lorenzo
S
S
López-Mahía
P
P
Fernández-Fernández
E
E
Prada-Rodríguez
D
D
D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000032:analysis*; D012680:Sensitivity and Specificity
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides