An Evolutionary Trace Method for Functional Prediction of Genomes.
It is essential for functional genomics to develop an accurate and efficient functional prediction method of genomes. Here, a new method is suggested, that is based on the fact that ortholog-specific motif is an evolutionary trace, in which the functional prediction of genomics is carried out. First, orthologous sets in a family were constructed using evolutionary analysis then functional motifs for each orthologous set were found out and a database consisted of these motifs was built. When this database is completed, unknown genes can be predicted accurately and quickly by searching it. The pilot study on five families proves that our method is feasible.
Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. dingdafu@server.shcnc.ac.cn
Tao
T
Xie
Jie
J
Chen
Da-Fu
DF
Ding