Effects of micronutrient supplements on u.v.-induced skin damage.
Development of an orally-administered systemic agent that could reduce the effects of u.v. exposure on skin could potentially have a major effect on the incidence of skin cancers and photo-ageing. A number of micronutrients have been suggested to have metabolic properties that could induce this protection, and our data indicate that n-3 polyunsaturated fatty acids are particularly effective in this role. The mechanisms of action of n-3 polyunsaturated fatty acids appear to depend on their anti-inflammatory properties, acting to reduce the u.v.-induced release of cytokines and other mediators from a variety of skin cell types.
Jackson
M J
MJ
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK. mjj@liv.ac.uk
Jackson
M J
MJ
McArdle
F
F
Storey
A
A
Jones
S A
SA
McArdle
A
A
Rhodes
L E
LE
D000375:Aging / Q000528:radiation effects; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage* / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000970:Antineoplastic Agents; D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D018977:Micronutrients