[Investigation of insertion/deletion polymorphism of the ACE gene in stroke patients].
BACKGROUND
This is the first Hungarian paper on the insertion/deletion polymorphism of ACE gene in stroke patients. According to literature data, the role of this polymorphism is controversial in the pathogenesis of stroke. The aim was to study the prevalence of the polymorphism in healthy persons and in stroke patients.


METHODS
Blood samples from 173 unrelated healthy donors and 253 stroke patients were investigated by polymerase chain reaction (PCR). PrevIous stroke was documented by CT or MRI and CDS. A routine questionnaire was used to study previous vascular events and the risk profile of patients.


RESULTS
I/I allele was found in 20%, I/D 52% and D/D 28% in the healthy group. Prevalence of the pathologic D/D allele did not differ between healthy and patients group (28% and 27%, OR: 0.88, and in subgroup age under 50 years OR: 1.00). No correlation was found between D/D and conventional risk profile but a positivE correlation was found in young patients having D/D and hyperlipidemia (p < 0.05) and hyperfibrinogenemia (p < 0.05). D/D prevalence was found higher in patients with family anamnesis of myocardial infarction (p < 0.05). Very low prevalence of D/D allele was found in cardiogen embolic group (p > 0.05).


CONCLUSIONS
The ACE polymorphism does not seem to be an independent risk factor for stroke. However, in young stroke patients with D/D allele, hyperlipidemia and/or hyperfibrinogenemia present very high risk for stroke.
Pongrácz
Endre
E
BM Központi Kórház, Neurológiai Osztály, 1071 Budapest, Városligeti fasor 9-13.
Tordai
Attila
A
Csornai
Márta
M
Nagy
Zoltán
Z
D000483:Alleles; D004251:DNA Transposable Elements; D017353:Gene Deletion; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000235:genetics*; D011795:Surveys and Questionnaires; D014652:Vascular Diseases / Q000150:complications / Q000235:genetics
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A