Hepatitis C virus and its roles in cell proliferation.
Hepatitis C virus (HCV) causes chronic hepatitis and is linked to the development of hepatocellular carcinoma (HCC). The role of HCV infection in the development of HCC remains to be clarified. We analyzed the effect of HCV core protein on modulation of cell proliferation. HCV core protein was shown to have at least two functions: activation of the Ras/Raf signaling pathway and anti-apototic function.
Shimotohno
Kunitada
K
Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan.
Watashi
Koichi
K
Tsuchihara
Katsuya
K
Fukuda
Katsuhiko
K
Marusawa
Hiroyuki
H
Hijikata
Makoto
M
D017209:Apoptosis / Q000502:physiology; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D016174:Hepacivirus / Q000472:pathogenicity* / Q000502:physiology*; D006526:Hepatitis C / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D019908:Proto-Oncogene Proteins c-raf / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014758:Viral Core Proteins / Q000502:physiology*; D018631:ras Proteins / Q000502:physiology
D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus; D019908:Proto-Oncogene Proteins c-raf; D018631:ras Proteins