18O incorporation in the oxidation of N-methylcarbazole by lignin peroxidase and a model compound: a mechanistic insight into the oxidative N-demethylation of aromatic tertiary amines.
Using 18O labelled reactants and/or solvent, the origin of the oxygen in the products of the oxidation of N-methylcarbazole by H2O2 catalysed by lignin peroxidase and a model compound has been determined, so getting important information about the mechanism of the oxidative N-demethylation of aromatic tertiary amines.
Baciocchi
Enrico
E
Dipartimento di Chimica, Università La Sapienza, P.le A. Moro 5, 00185 Roma, Italy. enrico.baciocchi@uniroma1.it
Gerini
Maria Francesca
MF
Lapi
Andrea
A
D000588:Amines / Q000737:chemistry / Q000378:metabolism*; D008745:Methylation; D010084:Oxidation-Reduction; D010103:Oxygen Isotopes / Q000493:pharmacokinetics; D010544:Peroxidases / Q000378:metabolism*
D000588:Amines; D010103:Oxygen Isotopes; D010544:Peroxidases; C042858:lignin peroxidase