Experimental study of Eudragit mixture as a new nonadhesive liquid embolic material.
OBJECTIVE
To assess the embolic effects and biocompatibility of Eudragit mixture, a new liquid embolic agent.


METHODS
In vitro, the viscosity and precipitation time of Eudragit mixtures at several concentrations were measured to study the best proportion of components of the mixture. In vivo, a branch of the right external carotid artery was embolized with Eudragit mixture in 12 rabbits, and with n-butyl cyanoacrylate in another 12 rabbits for a comparative study of the general, angiographic and histopathologic changes between the two groups.


RESULTS
Eudragit mixture containing 7.5 g Eudragit, 50 ml absolute ethanol and 50 ml iopromide was shown in vitro to have good properties including rapid precipitation and soft elastic sponge formation upon contact with blood; in vivo, to be nontoxic, nonadherent to the microcatheter and able to embolize the vascular lumen completely without later recanalisation.


CONCLUSIONS
Eudragit mixture is an effective, nontoxic, safe and promising liquid embolic agent.
Department of Neurosurgery, The First Affiliated Hosptial of Sun Yat-sen University, Guangzhou 510080, China. shizhongsong@yahoo.com.cn
Zhongsong
Z
Shi
Zhengsong
Z
Huang
Yuewei
Y
Zhang
Tiewei
T
Qi
Ming
M
Chu
Dashi
D
Bao
D000818:Animals; D002341:Carotid Artery Thrombosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D002533:Cerebral Angiography; D011232:Chemical Precipitation; D004617:Embolism / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D004659:Enbucrilate / Q000627:therapeutic use; D008297:Male; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D014783:Viscosity
D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D004659:Enbucrilate