Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia.
In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.
Hokkaido University, Sapporo, Japan.
Kumari
K
Lokugamage
Hiroaki
H
Kariwa
Daisuke
D
Hayasaka
Bai Zhong
BZ
Cui
Takuya
T
Iwasaki
Nandadeva
N
Lokugamage
Leonid I
LI
Ivanov
Vladimir I
VI
Volkov
Vladimir A
VA
Demenev
Raisa
R
Slonova
Galina
G
Kompanets
Tatyana
T
Kushnaryova
Takeshi
T
Kurata
Kenji
K
Maeda
Koichi
K
Araki
Tetsuya
T
Mizutani
Kumiko
K
Yoshimatsu
Jiro
J
Arikawa
Ikuo
I
Takashima
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D002353:Carrier State / Q000635:transmission / Q000662:veterinary / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D014644:Genetic Variation; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000635:transmission / Q000662:veterinary* / Q000821:virology*; D006801:Humans; D051379:Mice / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012426:Russia; D012689:Sequence Homology, Nucleic Acid
D000914:Antibodies, Viral; D004279:DNA, Viral; D012367:RNA, Viral