The interleukin-1 receptor antagonist gene: a single-copy variant of the intron 2 variable number tandem repeat (VNTR) polymorphism.
A variable number tandem repeat (VNTR) polymorphism exists within intron 2 of the human interleukin-1 receptor antagonist gene, consisting of perfect repeats of an 86-bp sequence. Five allelic variants have been identified wherein the number of repeats varies from two to six. This is the first report of a rare, single-copy allele designated IL1RN*0.
Vamvakopoulos
J E
JE
Department of Surgery, University of Cambridge, Cambridge, UK. molemed@hotmail.com
Taylor
C J
CJ
Morris-Stiff
G J
GJ
Green
C
C
Metcalfe
S
S
D000328:Adult; D017398:Alternative Splicing; D001483:Base Sequence; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D018598:Minisatellite Repeats; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012795:Sialoglycoproteins / Q000235:genetics*
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins