Mismatch repair defects as a cause of resistance to cytotoxic drugs.
In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.
Irving
J A
JA
Paediatric Oncology Research Unit, Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. j.a.e.irving@ncl.ac.uk
Hall
A G
AG
D020137:Base Pair Mismatch; D004260:DNA Repair; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D010641:Phenotype