Ethnicity and unprovoked hypokalemia in the Atherosclerosis Risk in Communities Study.
BACKGROUND
Hypertension is more prevalent in the African American population when compared with the European American population in the United States. Unprovoked hypokalemia may lead to hypertension and is associated with several forms of recognized secondary hypertension.


METHODS
We investigated the association of ethnicity with unprovoked hypokalemia in the second Atherosclerosis Risk in Communities (ARIC) study examination. Hypokalemia was defined as serum potassium <3.5 mmol/L.


RESULTS
A statistically significant association was detected between ethnicity and unprovoked hypokalemia (odds ratio = 5.3; 95% confidence interval = 3.6, 7.7) with unprovoked hypokalemia more prevalent in African Americans both before and after adjustment for important covariates. The unadjusted prevalence for unprovoked hypokalemia was 2.6% for African Americans and 0.5% for European Americans.


CONCLUSIONS
We found that the prevalence of unprovoked hypokalemia for African Americans in the ARIC cohort was more than five times that for European Americans. These data suggest that an increased awareness of hypokalemia and its etiology may be indicated for African Americans.
Jackson Heart Study Examination Center, University of Mississippi Medical Center, USA. mandrew@cdc.gov
Michael E
ME
Andrew
Daniel W
DW
Jones
Marion R
MR
Wofford
Sharon B
SB
Wyatt
Pamela J
PJ
Schreiner
C Andrew
CA
Brown
David B
DB
Young
Herman A
HA
Taylor
D001161:Arteriosclerosis / Q000208:ethnology*; D044383:Black People; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology*; D007008:Hypokalemia / Q000208:ethnology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D044465:White People; D001741:Black or African American
D011188:Potassium