In vitro inhibition of gene transcription by novel photo-activated polyazaaromatic ruthenium(II) complexes.
Under visible irradiation, [Ru(TAP)2(phen)]2+(Cl-)2, [Ru(TAP)2(POQ-Nmet)]2+(Cl-)2 and [Ru(bpy)2(phen)]2+(Cl-)2 were able to dramatically reduce the in vitro transcription of a plasmid DNA template by a bacteriophage RNA polymerase. This photoactivity is related to two different mechanisms of reactivity towards DNA exhibited by these complexes under illumination.
Pauly
Marc
M
Laboratoire de Recherche sur le Cancer et les Maladies du Sang, Avenue de la Faïencerie 162A, L-1511 Luxembourg, Luxembourg.
Kayser
Isabelle
I
Schmitz
Martine
M
Dicato
Mario
M
Del Guerzo
André
A
Kolber
Isabelle
I
Moucheron
Cécile
C
Mesmaeker
Andrée Kirsch-De
AK
D001372:Aza Compounds / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry; D010957:Plasmids; D017975:Ruthenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*
D001372:Aza Compounds; D017975:Ruthenium Compounds; D004247:DNA