Direct conversion of macrocyclic furans into macrocyclic isothiazoles.
The first calixhetarenes with more than one heteroatom in the constituent rings are prepared in one step by treatment of calix[4]furan 1a and calix[6]furan 1b with ethyl carbamate, thionyl chloride and pyridine to give 2, 3, 4 and 5, 6, 7 respectively; these products have been characterised by X-ray crystallography which reveals that in 2 all eight heteroatoms lie on one face of the macrocyle.
Chemistry Department, University of Sunderland, Sunderland, UK SR1 3SD.
Jérôme
J
Guillard
Otto
O
Meth-Cohn
Charles W
CW
Rees
Andrew J P
AJ
White
David J
DJ
Williams