Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression.
Growing evidence suggests that G-proteins may be involved in pathogenesis and treatment of affective disorders. Several studies have reported altered levels and/or activities of stimulatory G-proteins in depression. The aim of this study was to investigate whether a polymorphism in the stimulatory alpha subunit of G-proteins (T/C point mutation in exon 5; ATT --> ATC at codon 131) is associated with major depression or response to antidepressant treatment. Therefore, we performed a case-control association study with 212 depressive patients and 137 healthy, unrelated controls. There was no evidence for an association between the investigated polymorphism in the G(alpha)(s) gene and major depression, as well as to treatment response. The results of our study are in concordance with recently published findings which do not support the hypothesis that the gene for the stimulatory alpha subunit of G-proteins is a major susceptibility factor in the pathophysiology of major depression.
Psychiatric Hospital of the Ludwig-Maximilians-University, Munich, Germany. Peter.Zill@psy.med.uni-muenchen.de
Peter
P
Zill
Thomas C
TC
Baghai
Peter
P
Zwanzger
Cornelius
C
Schüle
Christo
C
Minov
Stefanie
S
Behrens
Rainer
R
Rupprecht
Hans-Jürgen
HJ
Möller
Rolf
R
Engel
Brigitta
B
Bondy
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide
D019205:GTP-Binding Protein alpha Subunits, Gs