Relationship among (1)H-magnetic resonance spectroscopy, brain volumetry and genetic polymorphisms in humans with memory impairment.
We investigated the relationship among neuroanatomical, neurochemical and genetic variables in 44 subjects with age-related memory impairment. Hydrogen magnetic resonance spectroscopy was used to determine N-acetyl/creatine (NAA/Cr) concentrations in basal ganglia and medial temporal regions. Volumetric measures were obtained for caudate nucleus and hippocampus. Genetic polymorphisms examined included apolipoproteins (APO) E and CI, angiotensin converting enzyme and dopamine D2 receptor TaqI genes. Age was found to be negatively correlated with hippocampal and basal ganglia volumes, but not with neurochemical values. Multiple regression analyses showed that the APOC1 polymorphism was the only variable which predicted NAA/Cr values in basal ganglia. NAA/Cr metabolites in the medial temporal lobe but not in the basal ganglia region were related with lower performance in verbal memory.
Bartrés-Faz
David
D
Departament de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, IDIBAPS, Casanova, 143, 08036, Catalonia, Barcelona, Spain. dbartres@psi.ub.es
Junqué
Carme
C
Clemente
Imma C
IC
López-Alomar
Antoni
A
Bargalló
Núria
N
Mercader
Josep M
JM
Moral
Pedro
P
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001479:Basal Ganglia / Q000378:metabolism; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008569:Memory Disorders / Q000235:genetics* / Q000378:metabolism*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011522:Protons; D013702:Temporal Lobe / Q000378:metabolism
D011522:Protons