Spontaneous remission of low-grade B-cell non-Hodgkin's lymphoma following withdrawal of methotrexate in a patient with rheumatoid arthritis: case report and review of the literature.
A 69-year-old woman, who had suffered from deforming rheumatoid arthritis since the age of 40 years, had been treated with methotrexate for 3 years. She presented with a 7 week history of neck lymphadenopathy. Biopsy revealed low-grade marginal-zone B-cell non-Hodgkin's lymphoma. Computerized tomography and bone marrow biopsy confirmed stage IIIA disease. Spontaneous complete remission of the lymphoma was achieved 14 months after withdrawing immune suppression with methotrexate.
Baird
Richard D
RD
Department of Haematology and Department of Rheumatology, Queen Mary's Hospital, Sidcup, Kent DA14 6LR, UK. r.baird@icr.ac.uk
van Zyl-Smit
Richard Nellis
RN
Dilke
Timothy
T
Scott
Sara E
SE
Rassam
Saad M B
SM
D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects*; D012075:Remission, Spontaneous
D018501:Antirheumatic Agents; D008727:Methotrexate