Albumin-controlled stereoselective reduction of 1,3-diketones to anti-diols.
An unprecedented combination of high chemo- and stereoselectivity in the NaBH4 reduction of 1:1 complexes between albumin and aromatic 1,3-diketones results in the formation of anti 1,3-diols with de up to 96%.
Benedetti
Fabio
F
Dipartimento di Scienze Chimiche, Università di Trieste, Via Giorgieri 1, I-34127 Trieste, Italy.
Berti
Federico
F
Donati
Ivan
I
Fregonese
Massimo
M
D007659:Ketones / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D012710:Serum Albumin, Bovine / Q000378:metabolism* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D007659:Ketones; D012710:Serum Albumin, Bovine