A preliminary study of dopamine-mediated prolactin inhibition in generalised social phobia.
The biology of social phobia has been little studied, but a possible role for dopamine has been implicated in this disorder. The aim of this study was to examine central dopaminergic function in patients with generalised social phobia using the prolactin response to quinagolide, a dopamine D2 receptor agonist, and to compare responses with those of normal controls. The study included 14 patients with moderate or severe generalised social phobia and 14 healthy age- and gender-matched comparison subjects. Quinagolide (0.5 mg) was administered orally and prolactin responses were measured over 4 h. There was no significant difference between prolactin responses in patients and healthy controls, nor was there a correlation between prolactin response and age, sex, or severity of illness. This would suggest that tuberoinfundibular dopamine D2 receptor sensitivity is normal in this disorder.
Neuroscience Department, St. Vincent's Hospital, Richmond Road, Fairview, 3, Dublin, Ireland.
Rita M
RM
Condren
Neda
N
Sharifi
Jogin H
JH
Thakore
D000328:Adult; D000634:Aminoquinolines / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000175:diagnosis / Q000378:metabolism*; D011388:Prolactin / Q000096:biosynthesis* / Q000097:blood; D017448:Receptors, Dopamine D2 / Q000187:drug effects*
D000634:Aminoquinolines; D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; C046650:quinagolide; D011388:Prolactin; D006854:Hydrocortisone