Forearm reactive hyperemic blood flow and arm-cranking exercise capacity in healthy and heart failure subjects.
BACKGROUND
The relationship between lower limbs maximal vasodilatory capacity and exercise capacity in congestive heart failure (CHF) and healthy subjects has been well-documented. However, the relationship between upper limbs maximal vasodilatory capacity and exercise is less well-established.


RESULTS
Twelve patients with CHF, 16 age-matched normal subjects, and 11 very fit individuals underwent an arm-cranking exercise test using maximal oxygen uptake (arm VO(2max)) and measurements of peak forearm reactive hyperemic blood flow. Despite similar forearm strength, arm VO(2max) was significantly reduced in patients with CHF when compared to normal and very fit individuals (13.9 +/- 2.9, 23.5 +/- 4.8, and 36.4 +/- 8.5 mL/kg/min, respectively, P <.05). Similarly, peak reactive hyperemia was lower in CHF patients as compared to normal and very fit individuals (18.6 +/- 5.9, 24.3 +/- 5.8, and 41.1 +/- 8.1 mL/100 mL/min, respectively, P <.05). There was a strong relationship between peak reactive hyperemic blood flow and arm VO(2max) (r =.75; P <.001) in all subjects.


CONCLUSIONS
These results suggest a significant relationship between forearm vasodilatory capacity and arm-cranking VO(2max) in CHF patients, sedentary, and very fit individuals.
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
Lizanne M
LM
Bussières
Martin
M
Juneau
Julie
J
Lalongé
Michel
M
White
Jean-Lucien
JL
Rouleau
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D015444:Exercise; D017079:Exercise Tolerance; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D012016:Reference Values; D014664:Vasodilation