Biocompatibility and in vivo gentamicin release from bioactive sol-gel glass implants.
Biomaterial pieces, with suitable osteogenic properties for use in the treatment of bone defects and the capability to avoid bone infections, have been synthesized. These materials are composed exclusively of gentamicin sulfate and bioactive SiO(2)-CaO-P(2)O(5) sol-gel glass (previously synthesized). Implant processing was achieved by uniaxial and isostatic pressure of the components mixture. After implanting the pieces into rabbit femur, we studied (i) the antibiotic release, determining the concentration in proximal and distal bone, liver, kidney, and lung as a function of time; and (ii) the bone growth resulting from the glass reactivity in the biologic environment. The results indicate that the implants are good carriers for local gentamicin release in the osseous tissue, exhibiting excellent biocompatibility and bone integration. Moreover, these implants are able to promote bone growth during their resorption process.
Meseguer-Olmo
L
L
Laboratorio de Cirugía Ortopédica Experimental, Facultad de Medicina, Universidad de Murcia, Spain.
Ros-Nicolás
M J
MJ
Clavel-Sainz
M
M
Vicente-Ortega
V
V
Alcaraz-Baños
M
M
Lax-Pérez
A
A
Arcos
D
D
Ragel
C V
CV
Vallet-Regí
M
M
D000818:Animals; D001672:Biocompatible Materials; D004058:Diffusion; D004337:Drug Carriers; D005269:Femur / Q000382:microbiology / Q000601:surgery; D005782:Gels; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005898:Glass; D017053:Infection Control; D019637:Orthopedic Procedures / Q000009:adverse effects / Q000379:methods*; D016348:Osseointegration; D011312:Pressure; D011817:Rabbits; D014018:Tissue Distribution
D001672:Biocompatible Materials; D004337:Drug Carriers; D005782:Gels; D005839:Gentamicins