Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children.
The present study was carried out to evaluate the effectiveness of nitazoxanide compared with that of quinfamide, mebendazole, or both in the treatment of intestinal protozoa and helminthic infections. A total of 677 stool specimens from children aged 2-12 years living in 3 communities of Colima, México, were analyzed in order to detect the presence of cysts, trophozoites, eggs, or larvae of intestinal protozoa or helminths. A total of 275 infected children were enlisted in a double-blind controlled study and randomly assigned to one of 2 treatment groups: Group A, nitazoxanide (200 mg for 3 days) and Group B, quinfamide (100 mg for 1 day), mebendazole (200 mg for 3 days), or both. A posttreatment fecal examination was conducted on Day 14 from treatment initiation. In Group A (n = 143), the parasitosis eradication rate was superior to that of Group B (n = 132). However, there was no significant difference between the 2 groups (P > 0.05).
Unidad de Investigación en Epidemiología Clínica, Hospital General de Zona y Medicina Familiar No. Uno, Dr. Leonel Ramírez García, Instituto Mexicano del Seguro Social, Colima, México.
Cesar E
CE
Davila-Gutierrez
Clemente
C
Vasquez
Benjamin
B
Trujillo-Hernandez
Miguel
M
Huerta
D000977:Antiparasitic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology; D009574:Nitro Compounds; D011528:Protozoan Infections / Q000188:drug therapy / Q000469:parasitology; D011804:Quinolines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome
D000977:Antiparasitic Agents; D009574:Nitro Compounds; D011804:Quinolines; D013844:Thiazoles; D008463:Mebendazole; C026546:quinfamide; C041747:nitazoxanide