[Effect of the novel dipeptide nootropic agent noopept and its metabolite cyclo-L-prolylglycine on the transcallosal evoked potential in the rat brain].
The effect of new nootropic dipeptides--noopept (N-phenylacetyl-L-prolylglycine, GVS-111) and its metabolite (cyclo-L-prolylglycine)--and a standard nootrope piracetam on the transcallosal evoked potential (TEP) in rat brain was studied. In the dose range from 150 to 300 mg/kg, piracetam increased the TEP amplitude, which exhibited a maximum after 1.5-2 h and then gradually decreased. Both noopept and cyclo-L-prolylglycine also increased the TEP amplitude, which attained a plateau and retained this level over the entire observation time (above 3.5 h). All the nootropes studied increased both components of the evoked potential. Piracetam and cyclo-L-prolylglycine led to an approximately equal increase in both waves, while noopept induced a somewhat greater increase in the negative TEP wave amplitude. It is suggested that the positive effect of noopept and cyclo-L-prolylglycine upon the interhemispheric signal transfer (indicated by the improved transcallosal response) can be considered as a potential neurophysiological basis for a positive drug influence on the behavioral level.
Molodavkin
G M
GM
Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Borlikova
G G
GG
Voronina
T A
TA
Gudasheva
T A
TA
Ostrovskaia
R U
RU
Tushmalova
N A
NA
Seredenin
S B
SB
D000818:Animals; D003337:Corpus Callosum / Q000187:drug effects* / Q000502:physiology; D004151:Dipeptides / Q000378:metabolism / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D018697:Nootropic Agents / Q000378:metabolism / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology; D051381:Rats
D004151:Dipeptides; D018697:Nootropic Agents; D010456:Peptides, Cyclic; C103871:ethyl phenylacetyl-Pro-Gly; C062238:cyclo(prolylglycyl); D005998:Glycine; D010889:Piracetam