Signaling the pathway to regeneration.
Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.
Snider
William D
WD
Neuroscience Center, University of North Carolina, Chapel Hill 27599, USA. wsnider@med.unc.edu
Zhou
Feng-Quan
FQ
Zhong
Jian
J
Markus
Annette
A
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology / Q000293:injuries / Q000378:metabolism; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*
D016207:Cytokines; D006133:Growth Substances; D000242:Cyclic AMP