Psychopharmacological studies on Tragia involucrata root extract.
The methanol fraction of the root extract of Tragia involucrata was investigated for psychopharmacological activity in rodents. It produced an alteration of behavioural pattern and a reduction in spontaneous motility. A significant potentiation of pentobarbitone-induced sleep, a decrease of body temperature, suppression of the aggressive behaviour pattern and of the conditioned avoidance response (CAR) were observed with the fraction. These suggest that the methanol fraction of the T. involucrata root extract possesses significant central nervous system depressant action.
Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.
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Dhara
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Pal
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Nag Chaudhuri
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000927:Anticonvulsants; D010936:Plant Extracts; D005680:gamma-Aminobutyric Acid