A clinical and experimental study on the protective effects of jiangzhi tongmai fang on endothelial injury.
31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang ([symbol: see text], formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was antiatherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1 alpha and decreasing the release of endothelin (ET) as evidenced in the experimental study.
Wang
Yahong
Y
Dongzhimen Hospital, Beijing TCM University, Beijing 100700.
Niu
Fuling
F
Zhao
Mingjing
M
Zhong
Bei
B
Hao
Jinghong
J
Yan
Weihong
W
Lu
Xiying
X
Wang
Wei
W
Li
Qiang
Q
Lin
Qian
Q
Dai
Yanyan
Y
Zhao
Yong
Y
Xiao
Min
M
Tang
Ling
L
He
Lanying
L
Jiang
Xueying
X
Guo
Weiqin
W
Wang
Shuoren
S
Lu
Weixing
W
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy*; D008078:Cholesterol, LDL / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D008148:Lovastatin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011817:Rabbits
D008078:Cholesterol, LDL; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D015121:6-Ketoprostaglandin F1 alpha; D008148:Lovastatin