Reduction of alpha-aryloxy carbonyl compounds with samarium(II) iodide. A new traceless linker for the solid phase synthesis of carbonyl compounds.
A new linker for the solid phase synthesis of functionalised carbonyl compounds which is cleaved under mild, neutral conditions using samarium(II) iodide has been developed; the manipulation of an immobilised gamma-butyrolactone has been carried out to illustrate the utility of the linker.
Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK G12 8QQ.
Fiona
F
McKerlie
David J
DJ
Procter
Graham
G
Wynne