Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women.
Oral N-acetylcysteine supplementation in nine young healthy females induced a quick and highly significant decrease in plasma homocysteine levels and an increase in whole blood concentration of the antioxidant glutathione. N-acetylcysteine impresses as an efficient drug in lowering homocysteine concentration and might be beneficial for individuals with hyperhomocysteinemia who are at increased risk of cardiovascular disease.
Department of Obstetrics and Gynecology, University Medical Centre, Nijmegen, The Netherlands.
Eva Maria
EM
Roes
Maarten T M
MT
Raijmakers
Wilbert H M
WH
Peters
Eric A P
EA
Steegers
D000111:Acetylcysteine / Q000008:administration & dosage* / Q000494:pharmacology; D000284:Administration, Oral; D000328:Adult; D000975:Antioxidants; D019587:Dietary Supplements; D005260:Female; D005978:Glutathione / Q000097:blood* / Q000187:drug effects; D006710:Homocysteine / Q000097:blood* / Q000187:drug effects; D006801:Humans; D020138:Hyperhomocysteinemia / Q000188:drug therapy
D000975:Antioxidants; D006710:Homocysteine; D005978:Glutathione; D000111:Acetylcysteine