CD40 ligand (CD154) does not contribute to lymphocyte-mediated inhibition of virulent Mycobacterium tuberculosis within human monocytes.
Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood lymphocytes and antigen-specific CD4+ T-cell lines likewise was not reduced by blocking anti-CD40L monoclonal antibody 5c8.
Division of Pulmonary and Critical Care Medicine, Case Western Reserve University School of Medicine, Ohio 44106-4984, USA.
Rhonda
R
Larkin
Christopher D
CD
Benjamin
Yen-Ming
YM
Hsu
Qing
Q
Li
Lynn
L
Zukowski
Richard F
RF
Silver
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D019013:CD40 Antigens / Q000096:biosynthesis / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D007424:Intracellular Fluid / Q000382:microbiology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology / Q000494:pharmacology; D014774:Virulence
D000911:Antibodies, Monoclonal; D019013:CD40 Antigens; D011994:Recombinant Proteins; D023201:CD40 Ligand