Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth.
Two new lipophilic tetraazamacrocycles were prepared and, in contrast to non-lipophilic analogs, found to be potent inhibitors of tumor cell growth in vitro with IC50 values below 10 micromolar.
Sibert
John W
JW
Department of Chemistry, University of Texas at Dallas, P.O. Box 830688, Richardson, TX 75083-0688, USA. sibertj@utdallas.edu
Cory
Ann H
AH
Cory
Joseph G
JG
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D008055:Lipids; C024560:cyclam