High variability of HLA-B27 alleles in ankylosing spondylitis and related spondyloarthropathies in the population of northern Spain.
The distribution of B27 alleles (B*2701-23) was characterized by PCR-SSP in ankylosing spondylitis and related spondyloarthropathies (SpA) in a sample of B27 positive patients from northern Spain. Six B27 alleles were identified: B*2705,02,03,07,08 and B*2713. B*2705 and 02 were the most common alleles in the SpA studied: ankylosing spondylitis (AS) (n = 89), reactive arthritis (ReA) (n = 11), psoriatic arthritis (PsA) (n = 29), and inflammatory bowel disease (IBD) (n = 21). B*2707 and B*2708 were found in PsA patients and B*2703 in one patient with IBD. B*2713 was identified in a healthy control family. B*2713 has not been reported to be represented in either ethnic group. Thus, this population shows higher levels of B27 diversity than other Caucasian groups.
Gonzalez
Segundo
S
Functional Biology Department (S.G.), University of Oviedo, Oviedo, Spain.
Garcia-Fernandez
Sonia
S
Martinez-Borra
Jesus
J
Blanco-Gelaz
Miguel Angel
MA
Rodrigo
Luis
L
Sanchez del Río
Jose
J
López-Vazquez
Antonio
A
Torre-Alonso
Juan Carlos
JC
López-Larrea
Carlos
C
D000483:Alleles; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D016133:Polymerase Chain Reaction; D000091402:Prohibitins; D013030:Spain; D025242:Spondylarthropathies / Q000235:genetics* / Q000276:immunology*; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology*
D015796:HLA-B27 Antigen; C000717331:PHB2 protein, human; D000091402:Prohibitins