Multi-subunit acetyl-CoA carboxylases.
Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.
Department of Microbiology, B103 Chemical and Life Sciences Laboratory, University of Illinois, 601 S. Goodwin Avenue, Urbana, IL 61801, USA. j-cronan@life.uiuc.edu
John E
JE
Cronan
Grover L
GL
Waldrop
D000103:Acetyl-CoA Carboxylase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002352:Carrier Proteins / Q000737:chemistry; D002384:Catalysis; D004926:Escherichia coli / Q000201:enzymology; D054889:Fatty Acid Synthase, Type II; D006801:Humans; D009154:Mutation; D010944:Plants / Q000201:enzymology; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D054889:Fatty Acid Synthase, Type II; D000103:Acetyl-CoA Carboxylase; C079633:biotin carboxyl carrier protein