Pentasaccharides.
Fondaparinux sodium is the first in a new class of antithrombotic agents possessing selective inhibitory activity against factor Xa. The agent was designed and developed with the objective of overcoming the limitations of currently available therapies for the prevention and treatment of venous and arterial thromboembolic disease. Extensive data from preclinical and clinical trials demonstrate fondaparinux's favorable pharmacokinetic profile combined with promising efficacy and safety results in the prevention of venous thromboembolism following major orthopedic surgery, in the treatment of deep venous thrombosis, and in acute coronary syndromes.
Hamilton Health Sciences-Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, L8L 2X2 Canada.
Alexander G G
AG
Turpie
D000818:Animals; D065427:Factor Xa Inhibitors; D000077425:Fondaparinux; D006801:Humans; D009844:Oligosaccharides / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011134:Polysaccharides / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D013923:Thromboembolism / Q000188:drug therapy / Q000517:prevention & control; D020246:Venous Thrombosis / Q000188:drug therapy / Q000517:prevention & control
D065427:Factor Xa Inhibitors; D009844:Oligosaccharides; D011134:Polysaccharides; D000077425:Fondaparinux