Tau function and dysfunction in neurons: its role in neurodegenerative disorders.
Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.
Avila
Jesús
J
Centro de Biología Molecular (CSIC-UAM), Universidad Autónoa, Madrid, Spain. javila@cbm.uam.es
Lim
Filip
F
Moreno
Francisco
F
Belmonte
Carlos
C
Cuello
A Claudio
AC
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology / Q000502:physiology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
D016875:tau Proteins