Characterization of a novel MICA allele, MICA*047.
We report the identification of a novel MICA allele, MICA*047. It was initially detected because of an unusual hybridization pattern with sequence-specific oligonucleotides (SSOP) in a normal subject of Caucasian origin. Cloning and sequencing of both strands, and comparison of the sequence with previously defined MICA alleles, revealed that the new allele is similar to MICA*041 except for one nucleotide substitution at position 811 (C-->G). It appears that this new allele could have been generated by an interallelic sequence exchange between MICA*011 and MICA*0411.
Zhang
Y
Y
Department of Internal Medicine, UT South-western Medical Center, Dallas 75390-8886, USA.
Lázaro
A M
AM
Mirbaha
F
F
Lavingia
B
B
Vorhaben
R
R
Stastny
P
P
D000483:Alleles; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012689:Sequence Homology, Nucleic Acid
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A