[Experimental and clinical rationale for complex treatment of mental disorders in clean-up workers of the Chernobyl nuclear plant accident].
Piracetam is an effective drug for the treatment of asthenic and intellectual-mnestic disorders. However, this drug induces superfluous stimulation which reduces the therapeutic effect in rescuers after Chernobyl nuclear power disaster. The results of experimental and clinical investigations show that the administration of gidazepam--an atypical benzodiazepine tranquilizer--in combination with piracetam produces correction of the undesired stimulant action of the latter drug, while potentiating the nootropic (antiamnesic) and anxiolytic effects. This drug interaction led to an improvement in the therapy.
Laboratory of Clinical Psychopharmacology, Laboratory of Psychopharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
G G
GG
Neznamov
V V
VV
Koshelev
T A
TA
Voronina
S S
SS
Trofimov
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001247:Asthenia / Q000188:drug therapy*; D001362:Avoidance Learning / Q000187:drug effects; D001569:Benzodiazepines; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D009043:Motor Activity / Q000187:drug effects; D018697:Nootropic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010889:Piracetam / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011210:Power Plants; D018788:Radioactive Hazard Release; D051381:Rats; D014455:Ukraine
D014151:Anti-Anxiety Agents; D018697:Nootropic Agents; D001569:Benzodiazepines; C077010:gidazepam; D010889:Piracetam