Diagnostic issues in liver transplantation pathology.
Liver biopsy is used to determine the pathogenesis of liver dysfunction after liver transplantation. One or more causative factors may be identified on biopsy. The pathologist must be familiar with the histopathology of acute rejection to differentiate it from other potential complications, including biliary obstruction, intercurrent cytomegalovirus hepatitis, or recurrent disease. Consensus documents from the Banff international panel provide useful guidelines for the appropriate grading of acute and chronic rejection.
Lefkowitch
Jay H
JH
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street-PH15 West 1574, New York, NY 10032, USA. jhl3@columbia.edu
D000208:Acute Disease; D003586:Cytomegalovirus Infections / Q000209:etiology; D006084:Graft Rejection; D019693:Hepatitis, Autoimmune / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology; D012008:Recurrence; D014019:Tissue Donors