Spontaneous remission of low-grade B-cell non-Hodgkin's lymphoma following withdrawal of methotrexate in a patient with rheumatoid arthritis: case report and review of the literature.
A 69-year-old woman, who had suffered from deforming rheumatoid arthritis since the age of 40 years, had been treated with methotrexate for 3 years. She presented with a 7 week history of neck lymphadenopathy. Biopsy revealed low-grade marginal-zone B-cell non-Hodgkin's lymphoma. Computerized tomography and bone marrow biopsy confirmed stage IIIA disease. Spontaneous complete remission of the lymphoma was achieved 14 months after withdrawing immune suppression with methotrexate.
Department of Haematology and Department of Rheumatology, Queen Mary's Hospital, Sidcup, Kent DA14 6LR, UK. r.baird@icr.ac.uk
Richard D
RD
Baird
Richard Nellis
RN
van Zyl-Smit
Timothy
T
Dilke
Sara E
SE
Scott
Saad M B
SM
Rassam
D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects*; D012075:Remission, Spontaneous
D018501:Antirheumatic Agents; D008727:Methotrexate