[Impairment of latent inhibition in OXYS rats with hereditary syndrome of premature aging].
The effect of latent inhibition has been tested in OXYS (strain selected for accelerated aging) and Wistar (control) rats at the age of 4 months using a conditioned passive avoidance reaction. The OXYS rats displayed a higher level of anxiety in the elevated plus-maze as compared to Wistar strain. The experimental procedure consisted of preexposure stage (presentation of non-reinforced environmental stimulus), conditioning (presentation of a preexposed stimulus paired with shock), and testing the effect of latent inhibition. The effect of latent inhibition was revealed only in Wistar rats, in which the latency of transition to the dark compartment of the experimental chamber was reduced. Contrastingly, in OXYS rats the conditioned performance was not inhibited. It is suggested that aging-associated factors such as the low rate of habituation to experimental situation at the preexposure stage and the high general anxiety level of OXYS rats can interfere with inhibition of the attention to irrelevant information.
Loskutova
L V
LV
Institute of Physiology, Russian Academy of Medical Sciences, Siberian Division, Novosibirsk.
Zelenkina
L M
LM
D019588:Aging, Premature / Q000235:genetics* / Q000523:psychology*; D000818:Animals; D007266:Inhibition, Psychological; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013577:Syndrome