About the use of protein models.
Protein models can be of great assistance in functional genomics, as they provide the structural insights often necessary to understand protein function. Although comparative modelling is far from yielding perfect structures, this is still the most reliable method and the quality of the predictions is now well understood. Models can be classified according to their correctness and accuracy, which will impact their applicability and usefulness in functional genomics and a variety of situations.
Peitsch
Manuel C
MC
Novartis Pharma AG, WKL-490.4.04, 4002 Basel, Switzerland Swiss Institute of Bioinformatics, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. manuel.peitsch@pharma.novartis.com
D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D008956:Models, Chemical; D008957:Models, Genetic; D008958:Models, Molecular; D015233:Models, Statistical; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017385:Sequence Homology
D008565:Membrane Proteins; D011506:Proteins