Molecular pathogenesis of iron overload.
Our current understanding of iron absorption under normal conditions is presented, together with an overview of the clinical disorders of iron overload and the molecular processes that contribute to increased iron deposition in iron overload. Recently, a number of new genes involved in iron metabolism have been identified which is allowing the molecular mechanisms of iron absorption to be elucidated.
Department of Medicine and Western Australian Institute for Medical Research, University of Western Australia, Freemantle, Australia.
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Trinder
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Fox
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Vautier
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Olynyk
D020895:Enterocytes / Q000378:metabolism*; D015870:Gene Expression; D006418:Heme / Q000378:metabolism; D006432:Hemochromatosis / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000235:genetics*; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D008954:Models, Biological; D011990:Receptors, Transferrin / Q000378:metabolism
D011990:Receptors, Transferrin; D006418:Heme; D007501:Iron