Transport of an antifungal trypsin inhibitor isolated from corn across the blood-brain barrier.
We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 microl/g. min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.
Banks
William A
WA
Geriatric Research, Educational, and Clinical Center, Veterans Affairs Medical Center, 915 N Grand Boulevard, St. Louis, MO 63106, USA. bankswa@slu.edu
Niehoff
Michael L
ML
Brown
Robert L
RL
Chen
Zhi-Yuan
ZY
Cleveland
Thomas E
TE
D000465:Algorithms; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D007275:Injections, Intravenous; D051379:Mice; D008813:Mice, Inbred ICR; D008970:Molecular Weight; D014361:Trypsin Inhibitors / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D003313:Zea mays / Q000737:chemistry*
D000935:Antifungal Agents; D014361:Trypsin Inhibitors