Aluminum L-glutamate complex in rat brain cortex: in vivo prevention of aluminum deposit by magnesium D-aspartate.
Our previous experiments in the rat showed that aluminum L-glutamate complex (Al L-Glu) crosses the blood-brain barrier and accumulates in selective brain areas and that Al salts may increase D-aspartic acid forms in living brain proteins, probably by inducing more thermodynamically stable structures than L isomers. As magnesium blocks NMDA receptors, D-aspartic acid was used in the present study in the form of magnesium salt to prevent the excitotoxicity of dicarboxylic amino acids. Effects on brain amino acids and Al cortex levels in mature rats were studied after chronic treatment with Al L-Glu or Na L-Glu alone or in association with magnesium D-aspartate (Mg D-Asp). Results demonstrate that treatment with Mg D-Asp induces a decrease in the Al concentration in brain cortex of Al L-Glu-treated rats. In aluminum-free treated controls, treatment with Mg D-Asp in association with Na L-Glu also induces a decrease in Al concentration in brain cortex. These data indicate that Mg D-Asp administration protects rat brain cortex from Al accumulation and suggest that this treatment may be useful in preventing brain Al intoxication.
Deloncle
Roger
R
Laboratoire de Chimie Bioinorganique, Faculté de Pharmacie, 31 rue Monge, 37200 Tours cedex, France. o.guillard@chu-poitiers.fr
Fauconneau
Bernard
B
Piriou
Alain
A
Huguet
François
F
Guillard
Olivier
O
D000535:Aluminum / Q000378:metabolism*; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002614:Chelating Agents / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D013237:Stereoisomerism
D000600:Amino Acids, Dicarboxylic; D002614:Chelating Agents; D001224:Aspartic Acid; D018698:Glutamic Acid; D000535:Aluminum