Defects in G1-S cell cycle control in head and neck cancer: a review.
Tumors gradually develop as a result of a multistep acquisition of genetic alterations and ultimately emerge as selfish, intruding and metastatic cells. The genetic defects associated with the process of tumor progression affect control of proliferation, programmed cell death, cell aging, angiogenesis, escape from immune control and metastasis. Fundamental cancer research over the last thirty years has revealed a multitude of genetic alterations which specify more or less separate steps in tumor development and which are collectively responsible for the process of tumor progression. The genes affected play in normal cells a crucial role in control over cell duplication and the interaction between cells, and between cells and their direct surrounding. This is illustrated on control during the G1/S phase of the cell cycle by its ultimate regulators: cyclins and cyclin dependent kinases. These proteins not only control the transition through the G1/S phase of the cell cycle, but also serve as mediators of the interaction between cells, and between cells and their surrounding. Defaults in the regulation of these proteins are associated with tumor progression, and, therefore, serve as targets for therapy. Defaults in those genes are found in various tumor types, although some of those prevail in particular tumor types. In this review emphasis is given to the defaults that occur in head and neck cancer.
Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands. rmichal@nki.nl
Rob J A M
RJ
Michalides
Michiel
M
van de Brekel
Fons
F
Balm
D000782:Aneuploidy; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation; D016213:Cyclins / Q000502:physiology; D004249:DNA Damage / Q000502:physiology; D016193:G1 Phase / Q000235:genetics / Q000502:physiology*; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D010766:Phosphorylation; D016196:S Phase / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D016213:Cyclins; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53