Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates.
A novel dendritic molecule with nine chlorambucil (CBL) residues on the surface and a maleimide moiety at the core terminus was synthesized using a convergent synthetic methodology. This molecule is ready for attachment to single-chain Fv antibodies (scFvs) to form antibody-multidrug immunoconjugates in an effort to study the relevance of drug/antibody molar ratio and the potency of these drug-antibody immunoconjugates. A monomer and a trimer with a similar structural motif were also prepared for comparative purposes.
Sun
Chengzao
C
Department of Chemistry, The Scripps Research Institute and the Skaggs Institute for Chemical Biology, 10550N. Torrey Pines Road, La Jolla, CA 92037, USA.
Wirsching
Peter
P
Janda
Kim D
KD
D000906:Antibodies / Q000737:chemistry* / Q000276:immunology; D002699:Chlorambucil / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D018796:Immunoconjugates / Q000737:chemistry*; D015394:Molecular Structure
D000906:Antibodies; D018796:Immunoconjugates; D002699:Chlorambucil