Gram-scale synthesis of (+)- and (-)-trans-10-amino-9-hydroxy-9,10-dihydrophenanthrene by enzymatic hydrolysis.
The enzymatic resolution of (+/-)-trans-10-azido-9-acetoxy-9,10-dihydrophenanthrene by Candida cylindracea lipase-catalyzed hydrolysis was achieved on the gram-scale with excellent yield and enantiomeric excess. The resulting (+)- and (-)-amino alcohols were derivatized to alpha-hydroxy-N-benzenesulphonamides.
Department of Organic Chemistry, Institut Químic de Sarrià, Barcelona, Spain. jirur@iqs.url.es
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Irurre
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M
Riera
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M
Guixá