Comparison of the efficacy of early versus late viral proteins in vaccination against SIV.
The immune response against early regulatory proteins of simian- and human immunodeficiency virus (SIV, HIV) has been associated with a milder course of infection. Here, we directly compared vaccination with Tat/Rev versus Pol/Gag. Challenge infection with SIVmac32H (pJ5) suggested that vaccination with Tat/Rev induced cellular immune responses that enabled cynomolgus macaques to more efficiently control SIV replication than the vaccine-induced immune responses against Pol/Gag. Vaccination with Tat/Rev resulted in reduced plasma SIV loads compared with control (P=0.058) or Pol/Gag-vaccinated (P=0.089) animals, with undetectable plasma viral loads in two of the four Tat/Rev-vaccinated animals. Therefore, the results warrant further investigation of the early regulatory proteins and their potential for vaccination against HIV.
Stittelaar
Koert J
KJ
Department of Virology, Erasmus Medical Centre Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
Gruters
Rob A
RA
Schutten
Martin
M
van Baalen
Carel A
CA
van Amerongen
Geert
G
Cranage
Martin
M
Liljeström
Peter
P
Sutter
Gerd
G
Osterhaus
Albert D M E
AD
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D001483:Base Sequence; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology; D015684:Gene Products, pol / Q000235:genetics / Q000276:immunology; D015694:Gene Products, rev / Q000235:genetics / Q000276:immunology; D015696:Gene Products, tat / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008252:Macaca fascicularis; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D018449:SAIDS Vaccines / Q000235:genetics / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D014766:Viremia / Q000276:immunology / Q000517:prevention & control / Q000821:virology
D000914:Antibodies, Viral; D015683:Gene Products, gag; D015684:Gene Products, pol; D015694:Gene Products, rev; D015696:Gene Products, tat; D012367:RNA, Viral; D018449:SAIDS Vaccines