Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone.
The reaction of 2-acetylpyridine 4N-dimethylthiosemicarbazone (HL) with GaCl(3) in absolute ethanol in 1:1 molar ratio yielded the complex [GaL(2)][GaCl(4)]. The crystal structure of the gallium(III) complex has been determined by X-ray diffraction methods. Infrared, electronic, ESI mass and (1)H, (13)C, (15)N and (71)Ga NMR spectra, as well as the thermal behaviour are reported. The cytotoxicity assay in several human cancer cell lines (SW480, SK-BR-3 and 41M) suggests that the gallium(III) complex might be endowed with promising antitumour properties. In vitro cytotoxic activity exceeds that of all other tested gallium(III) complexes and is slightly higher than that of HL.
Arion
Vladimir B
VB
Institute of Inorganic Chemistry of the University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria. arion@ap.univie.ac.at
Jakupec
Michael A
MA
Galanski
Mathea S
MS
Unfried
Peter
P
Keppler
Bernhard K
BK
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002277:Carcinoma; D005708:Gallium / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C466604:gallium(III) 2-acetylpyridine 4N-dimethylthiosemicarbazone; D005708:Gallium