Synthesis of a highly enantiomerically enriched silyllithium compound.
The highly enantiomerically enriched silyllithium compound lithiomethylphenyl(1-piperidinylmethyl)silane (4) reacts stereospecifically with chlorosilanes, but over a period of several hours slow racemization in solution at room temperature occurs, which can be suppressed by a transmetalation reaction with MgBr2(thf)4.
Institut für Anorganische Chemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany. c.strohmann@mail.uni-wuerzburg.de
Carsten
C
Strohmann
Jan
J
Hörnig
Dominik
D
Auer