Association between interleukin-6 gene polymorphism and human T-cell leukemia virus type I associated myelopathy.
We studied cytokine gene polymorphisms in the promoter region, including interleukin (IL)-6, IL-1beta, and IL-10, in Japanese patients with human T-cell leukemia virus type I (HTLV-I) associated myelopathy (HAM) (n = 65), asymptomatic HTLV-I carriers (n = 143), and HTLV-I seronegative, normal controls (n = 160). There was a significant difference between HAM patients and HTLV-I carriers in the distribution of IL-6 promoter polymorphism at position -634 (chi(2) = 9.90, p = 0.0071). The IL-6 genotype was also significantly different between HAM patients and normal controls (chi(2) = 11.53, p = 0.0033), while a similar distribution was observed in IL-1beta and IL-10 polymorphisms among HAM patients, carriers, and normal controls. The results suggest that IL-6 gene region may contribute to susceptibility to HAM, and that aberrant cytokine productions could be involved in the development of HAM.
Department of Clinical Neuroscience,Tokushima, Japan. m_nishim@clin.med.tokushima-u.ac.jp
Masataka
M
Nishimura
Masao
M
Matsuoka
Michiyuki
M
Maeda
Ikuko
I
Mizuta
Shuji
S
Mita
Makoto
M
Uchino
Makoto
M
Matsui
Yasuo
Y
Kuroda
Hideshi
H
Kawakami
Ryuji
R
Kaji
Akio
A
Adachi
Takashi
T
Uchiyama
D002353:Carrier State / Q000276:immunology; D016022:Case-Control Studies; D005787:Gene Frequency; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics*; D007564:Japan; D015493:Paraparesis, Tropical Spastic / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic
D007375:Interleukin-1; D015850:Interleukin-6; D016753:Interleukin-10