Potential motion related bias in the worn dosimeter measurements of two childhood leukemia studies.
Time averaged field measurements produced by a Positron dosimeter worn by study subjects was the primary method of exposure evaluation in two Canadian studies of childhood leukemia and AC magnetic field exposure. Statistically significant but mutually contradictory results obtained in the two studies, done in different locales but under similar study conditions, have not been explained. This report examines operational features of the Positron meter, including an unanticipated sensitivity to wearer motion. If the convalescent cases studied were less active than their healthy controls, as one might expect, then the meter's characteristic responses to motion, particularly as they would affect case-control distributions above and below the different referent group cutpoints used in the two studies, could help to explain both the unexpected inverse risks reported in the larger study and the unusually high risks reported in the smaller study.
Monitor Industries, Boulder, CO 80302, USA. edleeper@mymailstation.com
Ed
E
Leeper
Nancy
N
Wertheimer
D015982:Bias; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000453:epidemiology / Q000209:etiology*; D008280:Magnetics / Q000009:adverse effects / Q000295:instrumentation; D009038:Motion; D016017:Odds Ratio; D012307:Risk Factors