Clinical significance of serum and urinary c-erbB-2 levels in colorectal cancer.
In this study we measured serum and urinary c-erbB-2 levels in 63 patients with colorectal cancer and 29 healthy controls, assessing their role in cancer-specific survival and the effects of resectional surgery. Serum and urinary c-erbB-2 levels were measured by an enzyme-linked immunosorbent assay, preoperatively and 7 days following tumor resection. Preoperative serum c-erbB-2 concentrations were significantly higher in the cancer patients and correlated with disease stage and the presence of liver metastases. Urinary c-erbB-2 was detected more often in cancer patients, although levels did not differ from controls and there was no association with any clinicopathological variable. Serum c-erbB-2 levels decreased significantly in those patients resected for cure and were an independent prognostic factor for cancer-specific survival with higher preoperative concentrations correlating with worse overall survival. These findings suggest that serum assessment of c-erbB-2 concentration may be valuable in defining colorectal cancer prognosis.
First Department of Surgery, University of Athens, Medical School, Athens 115 27, Greece.
Christos
C
Tsigris
Anastasios J
AJ
Karayiannakis
Andrew
A
Zbar
Konstantinos N
KN
Syrigos
Nicolaos
N
Baibas
Theodoros
T
Diamantis
Dimitrios
D
Alexiou
D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine*; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000652:urine; D015179:Colorectal Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000652:urine; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood* / Q000378:metabolism; D012004:Rectal Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000652:urine; D012016:Reference Values; D015996:Survival Rate
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases