Synthesis and activity of phenyl derivatives containing 5,6-dimethylthieno[2,3-d]pyrimidin-4(1H)-one or 4H-pyrimido[5,4-b]indol-4-one heterocyclic system as potential nonsteroidal anti-inflammatory drugs.
The synthesis, the analgesic and anti-inflammatory activities of two series of phenyl derivatives containing 5,6-dimethyl-thieno[2,3-d]pyrimidin-4(1H)-one and 4H-pyrimido[5,4-b]indol-4-one system, respectively, are reported. Two of these derivatives, 6A and 9B, showed interesting activities. The results of the pharmacological assays are discussed.
Dipartimento di Scienze Farmaceutiche, Università di Catania, Catania, Italy. asantaga@mbox.unict.it
Andrea
A
Santagati
Giuseppe
G
Granata
Maria
M
Santagati
Vincenza
V
Cutuli
Nunzio Guido
NG
Mangano
Antonina
A
Caruso
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006168:Guinea Pigs; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D010538:Peritonitis / Q000139:chemically induced / Q000517:prevention & control; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013276:Stomach Ulcer / Q000139:chemically induced
C460900:4H-pyrimido(5,4-b)indol-4-one; C460899:5,6-dimethyl-thieno(2,3-d)pyrimidin-4(1H)-one; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D007211:Indoles; D011743:Pyrimidines; D011744:Pyrimidinones