Confocal microscopy in multiple myeloma crystalline keratopathy.
OBJECTIVE
To report confocal microscopy findings of a patient with multiple myeloma crystalline keratopathy and the response to treatment.


METHODS
Confocal microscopy images of the cornea were taken OU and the corneal crystals analyzed using the Cell Counter software.


RESULTS
Numerous hyperreflective globules 6-11 nm in size were located within the corneal epithelium and anterior stroma. These crystals obscured normal architectural detail of the cornea. After 6 months of chemotherapy, confocal microscopy was repeated and demonstrated decrease in the size and number of hyperreflective globules.


CONCLUSIONS
Confocal microscopy can enable the clinician to monitor the clinical response of multiple myeloma crystalline keratopathy to chemotherapeutic agents.
Buerk
Bruce M
BM
Department of Ophthalmology and Visual Sciences, UIC Eye Center, University of Illinois at Chicago, 1855 W. Taylor, Chicago, IL 60612, U.S.A.
Tu
Elmer
E
D000368:Aged; D003318:Corneal Opacity / Q000209:etiology*; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D009101:Multiple Myeloma / Q000150:complications*; D016896:Treatment Outcome; D014792:Visual Acuity