Toward positional cloning with SNPs.
Efficient methods are available for positional cloning of major genes by linkage and linkage disequilibrium (LD). The application of these methods to complex diseases is more demanding, but advances in sequencing the human genome, SNP discovery, high-throughput genotyping techniques, LD maps, and haplotype annotation are revolutionizing positional cloning of oligogenes for common multifactorial disease.
Morton
Newton E
NE
Human Genetics, Southampton General Hospital, UK. nem@soton.ac.uk
Collins
Andrew
A
D000483:Alleles; D002874:Chromosome Mapping; D003001:Cloning, Molecular / Q000379:methods*; D008040:Genetic Linkage; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D020412:Multifactorial Inheritance; D020641:Polymorphism, Single Nucleotide; D013223:Statistics as Topic