Chromosome dynamics: new light on Aurora B kinase function.
Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in chromosome condensation and cohesion.
Shannon
Katie B
KB
University of North Carolina, Department of Biology, 607 Fordham Hall, CB#3280, Chapel Hill 27599-3280, USA.
Salmon
E D
ED
D000818:Animals; D064107:Aurora Kinase B; D064127:Aurora Kinases; D001324:Autoantigens; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology; D004398:Dyneins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D018386:Kinetochores / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis / Q000502:physiology; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins
D001324:Autoantigens; D029742:Caenorhabditis elegans Proteins; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone; D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; C068688:centromere protein E; D011494:Protein Kinases; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; C576961:IPL1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases; D004398:Dyneins