[Use of recombinant Salmonella strains for supplying the macro-organism with biologically active molecules].
The characterization of known Salmonella vaccine strains and different attenuated mutants used for developing new vaccines is presented. The use of attenuated Salmonella strains as vaccine vector for the supply of heterologous antigens opens prospects for the creation of effective and commonly available vaccines which approximate the "ideal" vaccine in their qualitative characteristics. The possibility of the genetic modification of attenuated strains permits their targeted reconstruction, considering the specific features of the formation of immune response to the definite heterologous antigen supplied to the body by the bacterial vector.
Gamaleya Research Institute of Epidemiology and Microbiology, Sechenov Medical Academy, Moscow, Russia.
V M
VM
Bondarenko
V A
VA
Beliavskaia
A A
AA
Vorob'ev
D001426:Bacterial Proteins / Q000235:genetics; D005822:Genetic Vectors; D006360:Heat-Shock Proteins; D009154:Mutation; D033903:Periplasmic Proteins; D012475:Salmonella / Q000235:genetics* / Q000276:immunology; D022562:Salmonella Vaccines / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D014436:Typhoid-Paratyphoid Vaccines / Q000235:genetics*; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic
D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; D033903:Periplasmic Proteins; C079792:PhoQ protein, Bacteria; D022562:Salmonella Vaccines; D014157:Transcription Factors; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; C087350:aroA Salmonella vaccine; C061064:PhoP protein, Bacteria; C061682:DegP protease; D012697:Serine Endopeptidases