A rat linkage map based on BC x LEW intercross.
A genetic linkage map consisting of 258 polymorphic loci has been constructed on the basis of an F2 intercross between the BC/CpbU and LEW/OlaHsd inbred rat strains. When compared to previously published maps a discrepancy was found for rat chromosome 7. The map spans a sex-averaged genetic length of 1790 cM and has an average marker spacing of 7.7 cM. It was estimated that this genetic map is linked to about 90% of the DNA in the rat genome. Because LEW/OlaHsd and BC/CpbU strains differ for dietary cholesterol susceptibility and hepatic copper content, the map is considered to be a valuable tool for studying the genetic background of these complex traits.
Bonné
A C M
AC
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. Bonne@las.vet.uu.nl
den Bieman
M G C W
MG
Gillissen
G F
GF
van Zutphen
L F M
LF
van Lith
H A
HA
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005819:Genetic Markers; D051379:Mice; D018895:Microsatellite Repeats; D051381:Rats; D011917:Rats, Inbred Lew
D005819:Genetic Markers