Extremely low frequency (ELF) pulsed-gradient magnetic fields inhibit malignant tumour growth at different biological levels.
Extremely low frequency (ELF) pulsed-gradient magnetic field (with the maximum intensity of 0.6-2.0 T, gradient of 10-100 T.M(-1), pulse width of 20-200 ms and frequency of 0.16-1.34 Hz treatment of mice can inhibit murine malignant tumour growth, as seen from analyses at different hierarchical levels, from organism, organ, to tissue, and down to cell and macromolecules. Such magnetic fields induce apoptosis of cancer cells, and arrest neoangiogenesis, preventing a supply developing to the tumour. The growth of sarcomas might be amenable to such new method of treatment.
Biomedical Physics Unit, Department of Physics, Wuhan University, Wuhan, 430072, China.
Xinchen
X
Zhang
Husheng
H
Zhang
Congyi
C
Zheng
Chaoyang
C
Li
Xinsong
X
Zhang
Wei
W
Xiong
D000818:Animals; D017209:Apoptosis / Q000502:physiology / Q000528:radiation effects; D002467:Cell Nucleus / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure; D004599:Electric Stimulation Therapy / Q000379:methods*; D004574:Electromagnetic Fields; D018870:Endoplasmic Reticulum, Rough / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure; D008280:Magnetics / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D046529:Microscopy, Electron, Transmission; D008928:Mitochondria / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure; D012513:Sarcoma, Experimental / Q000473:pathology / Q000628:therapy* / Q000648:ultrastructure; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000628:therapy* / Q000648:ultrastructure