The effect of pre-existing ischaemic heart disease on renal dysfunction in cardiac transplant recipients.
Renal dysfunction is a recognized complication of cardiac transplantation and can impact on the life expectancy of an already fragile population. A large proportion of these patients require transplantation because of the consequences of ischaemic heart disease (IHD) which, in turn, is often associated with ischaemic nephropathy. We studied the effect of IHD, diagnosed prior to transplantation, on the renal function of recipients who survived more than 6months after surgery. Of the 168 patients transplanted in a single centre over 15 years, 132 were included in the study. Renal dysfunction was defined as a serum creatinine consistently above 200 micromol/L (2.26 mg/dL). Analysis confirmed that IHD was an independent risk factor for developing renal impairment. In transplant recipients with IHD, closer monitoring is warranted to detect and prevent renal dysfunction or to retard its progression.
Abraham
Kottarathil A
KA
Department of Nephrology, Mater Misericordiae Hospital, Dublin, Ireland. abrahamka@hotmail.com
McGorrian
Catherine
C
O'Kelly
Patrick
P
Neligan
Maurice
M
Woods
Alfred E
AE
Conlon
Peter J
PJ
Donohoe
John
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000601:surgery*; D012307:Risk Factors; D012727:Sex Characteristics; D015996:Survival Rate; D013997:Time Factors
D003404:Creatinine