Persistent aplasia after chemotherapy for acute myeloid leukaemia treated with stem cell transplantation from a matched unrelated donor after dose-reduced conditioning.
Persistent aplasia is a rare complication with poor prognosis after intensive chemotherapy for acute leukaemia. A 59-year-old man with acute myeloid leukaemia (AML), was treated after 186 d of chemotherapy-induced persistent aplasia with an allogeneic peripheral blood stem cell transplantation (PBSCT) from a matched unrelated donor (MUD) after dose-reduced conditioning. The patient remains in complete haematological remission more than 8.5 months after haematological recovery. We believe that this is the first reported case of treatment for chemotherapy-induced persistent aplasia with MUD-PBSCT after dose-reduced conditioning, a procedure that can be successfully performed even in elderly patients.
Hambach
Lothar
L
Department of Haematology and Oncology, Hannover Medical School, Hannover, Germany. lothar_hambach@yahoo.de
Heil
Gerhard
G
Hertenstein
Bernd
B
Ganser
Arnold
A
D000208:Acute Disease; D000740:Anemia / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous