Hypertriglyceridemia is an independent risk factor for development of impaired fasting glucose and diabetes mellitus: a 9-year longitudinal study in Japanese.
OBJECTIVE
Hypertriglyceridemia is often associated with impaired fasting glucose (IFG) and diabetes mellitus. But the contribution of hypertriglyceridemia to the development of IFG and diabetes mellitus remains unclear. We evaluated whether or not hypertriglyceridemia is a risk factor for the development of IFG and diabetes mellitus.


METHODS
From 1990 through 1999, 7, 222 Japanese with normoglycemia at baseline were followed. Fasting plasma glucose levels were measured. IFG and diabetes mellitus were defined by ADA criteria.


RESULTS
The multivariate-adjusted relative risks for the development of IFG were 1.38 for hypertriglyceridemia (p=0.001), 1.30 for obesity (p=0.003), 1.29 for hypertension (p=0.007), 1.26 for family history of diabetes (p=0.027), and 1.02 for age (p=0.035). The multivariate-adjusted relative risks for the development of diabetes mellitus were 1.003 for triglyceride level (p=0.013), 1.30 for level of body mass index (p=0.003), and 2.38 for family history of diabetes (p=0.001).


CONCLUSIONS
Hypertriglyceridemia is an independent risk factor for the development of IFG and diabetes mellitus in Japanese patients.
Kametani
Tomio
T
Department of Internal Medicine, Kouseiren Takaoka Hospital, Toyama.
Koshida
Hideo
H
Nagaoka
Tadasu
T
Miyakoshi
Hisatugu
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D015228:Hypertriglyceridemia / Q000150:complications* / Q000453:epidemiology*; D015994:Incidence; D007564:Japan; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
D001786:Blood Glucose; D005947:Glucose