Inhibition of feline immunodeficiency virus (FIV) replication by DNA binding polyamides.
Two DNA minor-groove binding polyamides 1 and 2 were designed and synthesized and evaluated for inhibition of FIV-34TF10 replication. Both 1 and 2 decreased the replication of FIV-34TF10 by 75% by acting at the level of the virus but outside of the LTR or env region.
Sharma
Sanjay K
SK
Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G 2G2.
Billaud
Jean-Noel
JN
Tandon
Manju
M
Billet
Olivier
O
Choi
Sam
S
Kopka
Mary L
ML
Phillips
Tom R
TR
Lown
J William
JW
D000107:Acetylation; D000704:Analysis of Variance; D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000821:virology; D002415:Cats; D002460:Cell Line; D015500:Chloramphenicol O-Acetyltransferase / Q000032:analysis; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000378:metabolism*; D015195:Drug Design; D005333:Fetus; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism / Q000821:virology; D009757:Nylons / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D009757:Nylons; D011993:Recombinant Fusion Proteins; D015500:Chloramphenicol O-Acetyltransferase; D012194:RNA-Directed DNA Polymerase