Effect of subchronic ethanol treatment on plasma and cerebrospinal fluid leptin levels in rats selectively bred for high and low alcohol preference.
The effect of 5-week voluntary ethanol (EtOH) intake on plasma and cerebrospinal fluid (CSF) leptin levels was determined in adult male Warsaw high EtOH preferring (WHP) and low preferring (WLP) rats. EtOH treatment led to a decrease in leptin CSF concentration in WHP rats when compared to EtOH-naive WHP and control Wistar rats. On the contrary, in EtOH-treated WLP rats, both plasma and CSF leptin levels were increased in comparison with EtOH-naive animals. It can be concluded that EtOH treatment led to different response expressed especially by CSF leptin levels in WHP and WLP animals and it may be related to their genetic predisposition.
Department of Pharmacology, K. Marcinkowski University of Medical Sciences, Poznań, Poland. aspm@usoms.poznan.pl
Przemysław
P
Mikołajczak
Irena
I
Okulicz-Kozaryn
Ewa
E
Kamińska
Krzysztof
K
Wiktorowicz
Kinga
K
Leśniewska
Wanda
W
Dyr
Wojciech
W
Kostowski
D000428:Alcohol Drinking / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*; D000437:Alcoholism / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D020738:Leptin / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D020738:Leptin; D000431:Ethanol