Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues.
The synthesis and biological evaluation of new diadenosine polyphosphate analogues on blood platelet aggregation are reported. The most active are compounds with a sulfur atom replacing one or both non-bridging oxygens at phosphorus bound to adenosyl residues and hydroxymethyl groups of bis(hydroxymethyl)phosphinic acid.
Walkowiak
Bogdan
B
Department of Molecular and Medical Biophysics, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland. bogdan.walkowiak@csk.am.lodz.pl
Baraniak
Janina
J
Cierniewski
Czeslaw S
CS
Stec
Wojciech
W
D000241:Adenosine / Q000031:analogs & derivatives*; D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001665:Binding Sites; D015226:Dinucleoside Phosphates / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013329:Structure-Activity Relationship
D015226:Dinucleoside Phosphates; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D000241:Adenosine