[Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia].
The purpose of this study was to evaluate the prevalence of Epstein-Barr virus in Hodgkin disease in Tunisia through a series of 77 cases. Association with Epstein-Barr virus was demonstrated by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization in 70% of cases and by latent membrane protein 1 (LMP1) immunohistochemistry in 58.4% of cases. EBER positive cases were more frequent in extreme age classes (<15 and>54 years) there was no correlation with sex, histologic sub-type and clinical stage. Our findings show a high prevalence for EBV infection in Tunisian Hodgkin's disease particularly among extreme ages.
Korbi
Sadok
S
Laboratoire d'Anatomie et de Cytologie Pathologiques, CHU Farhat Hached, 4000 Sousse, Tunisie, France. sadok.korbi@uc.mu.tn
Trimeche
Mounir
M
Sriha
Badreddine
B
Yacoubi
Mohamed Tahar
MT
Hmissa
Sihem
S
Mokni
Moncef
M
Delvenne
Philippe
P
Boniver
Jacques
J
Rammeh
Soumaya
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000453:epidemiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000150:complications / Q000821:virology*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014416:Tunisia / Q000453:epidemiology; D014763:Viral Matrix Proteins / Q000032:analysis
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins