Improvement of the accuracy by the measurement of the electrical cell membrane parameters.
The electrical parameters of the cell membrane are mostly estimated employing ac methods. The measurement is based on the analysis of the current(s) flowing through an access resistance and the membrane. A current/potential transducer is used at the input of the device. The parameters of this transducer, especially its feedback capacity, degrades the accuracy of the measurement and hence diminishes the suppression of mutual influences of the individual parameters. The paper suggests a possible software correction and is supplemented by remarks for practical application.
Institute of Physiology, Czech Academy of Sciences, Prague. Rohlicek@biomed.cas.cz
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D002462:Cell Membrane / Q000502:physiology*; D004553:Electric Conductivity; D017097:Electric Impedance; D005089:Exocytosis / Q000502:physiology; D008954:Models, Biological; D018408:Patch-Clamp Techniques / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D015203:Reproducibility of Results