Obesity therapy: altering the energy intake-and-expenditure balance sheet.
Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.
University Departments of Medicine and Clinical Biochemistry, Addenbrooke's Hospital, Cambridge CB2 2QR, UK.
Vivion E F
VE
Crowley
Giles S H
GS
Yeo
Stephen
S
O'Rahilly
D002001:Adipose Tissue, Brown / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology; D002149:Energy Intake; D004734:Energy Metabolism; D006801:Humans; D007028:Hypothalamic Hormones / Q000502:physiology; D020738:Leptin / Q000502:physiology; D008543:Melanins / Q000502:physiology; D009478:Neuropeptide Y / Q000502:physiology; D009765:Obesity / Q000378:metabolism / Q000628:therapy*; D010907:Pituitary Hormones / Q000502:physiology; D011333:Pro-Opiomelanocortin / Q000502:physiology; D043643:Receptor, Muscarinic M1; D011956:Receptors, Cell Surface; D018043:Receptors, Corticotropin / Q000502:physiology; D054411:Receptors, Leptin; D044101:Receptors, Melanocortin; D011976:Receptors, Muscarinic / Q000502:physiology; D011979:Receptors, Pituitary Hormone / Q000502:physiology; D014158:Transcription, Genetic
D002352:Carrier Proteins; D007028:Hypothalamic Hormones; D020738:Leptin; D008543:Melanins; D009478:Neuropeptide Y; D010907:Pituitary Hormones; D043643:Receptor, Muscarinic M1; D011956:Receptors, Cell Surface; D018043:Receptors, Corticotropin; D054411:Receptors, Leptin; D044101:Receptors, Melanocortin; D011976:Receptors, Muscarinic; D011979:Receptors, Pituitary Hormone; C092274:melanin-concentrating hormone receptor; D011333:Pro-Opiomelanocortin; C019463:melanin-concentrating hormone