[Role of lymphokines in immune response in respiratory viral infections].
The present review deals with the analysis of lymphokine response in two main respiratory viral infections: influenza and respiratory syncytial (RS) infection. Immune response in these two diseases has great phenomenological differences. In particular, in RS infection the intensive response of macrophages and epithelial cells, accompanied mainly by the synthesis and secretion of tumor necrosis factor and interleukin 8, is observed. Due to this fact no protective immunity is formed in RS infection, in contrast to influenza. The specific features of immune and lymphokine response in RS infection make it difficult to develop protective vaccines. At the same time it is with RS infection that the development of chronic bronchopulmonary diseases is linked. The analysis of the role of lymphokine response in respiratory viral infections, particularly in influenza and RS infections, confirms the necessity of revising therapy both in the acute and subacute stages of these diseases.
Research Institute of Influenza, St. Petersburg, Russia.
O I
OI
Kiselev
I A
IA
Vasil'eva
E B
EB
Chepik
D001982:Bronchial Diseases / Q000209:etiology; D002908:Chronic Disease; D004847:Epithelial Cells / Q000276:immunology; D006801:Humans; D007251:Influenza, Human / Q000276:immunology*; D016209:Interleukin-8 / Q000032:analysis / Q000096:biosynthesis; D008222:Lymphokines / Q000502:physiology*; D008264:Macrophages / Q000276:immunology; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis
D016209:Interleukin-8; D008222:Lymphokines; D014409:Tumor Necrosis Factor-alpha