Prolactin/cortisol ratio in rheumatoid arthritis.
Prolactin (PRL) and glucocorticoids are hormones involved in the regulation of the immune system. Rheumatoid arthritis (RA) is an inflammatory condition that presents a diurnal rhythm of disease activity. PRL/cortisol ratio, and IL-1beta and TNF-alpha levels were determined in patients with RA and in control subjects at 0600, 1000, 1400, 1800, 2200, and 0200 hours. In patients with RA we observed higher PRL/cortisol ratio at 0200 hours, whereas IL-1beta and TNF-alpha reached their highest serum levels at 0200 and 0600 hours. In patients with RA we observed an imbalance in favor of proinflammatory hormones as opposed to levels of antiinflammatory hormones during nocturnal hours together with increased levels of IL-1beta and TNF-alpha of the diurnal rhythm of disease activity.
Istituto di Medicina Interna e Geriatria, Università Cattolica del Sacro Cuore A. Gemelli, Rome, Italy.
Angelo
A
Zoli
Ester Maria
EM
Ferlisi
Marco
M
Lizzio
Lorenzo
L
Altomonte
Luisa
L
Mirone
Angela
A
Barini
Flavia
F
Scuderi
F
F
Bartolozzi
Mario
M
Magaro
D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D015992:Body Mass Index; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D006966:Hyperprolactinemia / Q000097:blood / Q000209:etiology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007375:Interleukin-1 / Q000097:blood; D008875:Middle Aged; D015213:Neuroimmunomodulation; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D017698:Postmenopause / Q000097:blood; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D012636:Secretory Rate; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D011388:Prolactin; D006854:Hydrocortisone