Effects of sumatriptan on cerebral blood flow under normo- and hypercapnia in rats.
To investigate further the pharmacological mechanism of an anti-migraine drug, sumatriptan, a 5-HT1B/1D receptor agonist, we studied its effect on the cerebral circulation in seven anaesthetized rats, particularly during hypercapnia. After injection of 0.6 or 6.0 microg/kg sumatriptan succinate, no significant change in cerebral blood flow (CBF) was observed either in the striatum or in the parietal cortex. The increase in CBF both in the parietal cortex and the striatum during 5% CO2 inhalation was significantly less when sumatriptan succinate 6.0 microg/kg was injected. Sumatriptan appeared to have a vasoconstrictor effect on the relaxed vessels by CO2 inhalation. This mechanism might be attributable to vasoconstriction through activation of 5-HT1B receptors located in the vascular smooth muscle rather than 5-HT1B receptors in the vascular adventitia.
Fukuda
M
M
Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Japan. hukuta-m@dd.catv.ne.jp
Suzuki
N
N
Maruyama
S
S
Dobashi
K
K
Kitamura
A
A
Sakai
F
F
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D003342:Corpus Striatum / Q000098:blood supply; D006935:Hypercapnia / Q000503:physiopathology*; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010296:Parietal Lobe / Q000098:blood supply; D051381:Rats; D017207:Rats, Sprague-Dawley; D018170:Sumatriptan / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D018170:Sumatriptan