Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth.
Two new lipophilic tetraazamacrocycles were prepared and, in contrast to non-lipophilic analogs, found to be potent inhibitors of tumor cell growth in vitro with IC50 values below 10 micromolar.
Department of Chemistry, University of Texas at Dallas, P.O. Box 830688, Richardson, TX 75083-0688, USA. sibertj@utdallas.edu
John W
JW
Sibert
Ann H
AH
Cory
Joseph G
JG
Cory
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D008055:Lipids; C024560:cyclam