Morphology of accessory sex organs from neonatally DES- and DES-dp-injected mouse.
The neonatal estrogen induces morphological changes in accessory sex organs. We have reported that papillary proliferation in prostates and squamous metaplasia of the epithelium in seminal vesicle occurred and inflammatory cells have emigrated to the lumen through the stroma and the epithelium of organs from neonatal mice treated with beta-estradiol 17-cypionate. In this study, we observed the different effect between neonatal DES and DES-dp on morphological changes in accessory sex organs of mice. After 25 weeks, neonatal estrogen injections induced the infiltration of inflammatory cells in the ventral prostate and squamous metaplasia in the epithelium of seminal vesicles. It was observed that the inflammatory cells have already infiltrated into prostates from DES-dp injected mice after 5 weeks. But DES did not cause the changes in prostates. DES induced organs from a half of mice to involute and inflammatory cell to infiltrate into the epithelium. But these were not seen in organs from another half of mice. DES-dp occurred similar effect of beta-estradiol 17-cypionate on the male accessory sex organs. It remained to be seen whether DES could have estrogen action on accessory sex organ.
Kawamura
Hideto
H
First Department of Anatomy, Aichi Medical University School of Medicine, Japan.
Nonogaki
Tsunemasa
T
Yoshikawa
Kazuhiro
K
Kimura
Masaru
M
Nakano
Takashi
T
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004054:Diethylstilbestrol / Q000031:analogs & derivatives / Q000633:toxicity*; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D012669:Seminal Vesicles / Q000187:drug effects* / Q000473:pathology
D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol; C004955:fosfestrol