Incidence, epidemiology, and characteristics of quinolone-nonsusceptible Streptococcus pneumoniae in Croatia.
Among 585 Streptococcus pneumoniae strains isolated in 22 Croatian hospitals 21 strains (3.6%) were quinolone nonsusceptible. MICs of all quinolones were high for seven strains tested with the same serotype (23F) and mutations in gyrA, parC, and parE. The remaining 14 strains were more heterogeneous and had mutations only in parC and/or parE, and the MICs of quinolones were lower for these strains.
Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.
Glenn A
GA
Pankuch
Bülent
B
Bozdogan
Kensuke
K
Nagai
Arjana
A
Tambić-Andrasević
Slavko
S
Schoenwald
Tera
T
Tambić
Smilja
S
Kalenić
Sanja
S
Plesko
Nastja K
NK
Tepes
Zdenka
Z
Kotarski
Marina
M
Payerl-Pal
Peter C
PC
Appelbaum
D042462:4-Quinolones; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology; D017523:Croatia / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004352:Drug Resistance, Microbial; D005260:Female; D005843:Geography; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D012737:Sex Factors; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics
D042462:4-Quinolones; D000900:Anti-Bacterial Agents