5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
Novel 5,5-fused thiophene lactams are potent inhibitors and acylating agents of HNE and PPE.
Migaud
Marie E
ME
Oxford Centre for Molecular Sciences, Dyson Perrins Laboratory, South Parks Road, Oxford, UK OX1 3QY.
Wilmouth
Rupert C
RC
Mills
Gary I
GI
Wayne
Gareth J
GJ
Risley
Catherine
C
Chambers
Christopher
C
Macdonald
Simon J F
SJ
Schofield
Christopher J
CJ
D000477:Alkylating Agents / Q000138:chemical synthesis; D000818:Animals; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006801:Humans; D007769:Lactams / Q000138:chemical synthesis*; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis*; D013552:Swine; D013876:Thiophenes / Q000138:chemical synthesis*
D000477:Alkylating Agents; D007769:Lactams; D015842:Serine Proteinase Inhibitors; D013876:Thiophenes; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase