[Theoretical analysis of the reason for unsatisfactory approximation of experimental data on fractionated effect of gamma-radiation and (or) neutrons on lymphocytes at the G0 and G1 stage].
The causes were analyzed of unsatisfactory approximation, based on a mathematical model of cytogenetic effect of interaction of lesions induced by two doses of gamma-radiation and/or neutron in human blood lymphocytes at the stage G0 and G1. For the analysis the published data were used concerning the effect of inhibitors of protein and DNA synthesis on aberration yield in G0- and G1-cell cycle stages at different periods of time after their irradiation with different doses of gamma-rays and neutrons. It is assumed that the cause of the unsatisfactory approximation is the effect of the combined repair of lesions caused by two dose fractions under the process of replication repair caused by the first dose fraction.
Pozdyshkina
O V
OV
Medical Radiological Research Center, Russian Academy of Malical Sciences, Obninsk, 249036 Russia. sevankaev@rambler.ru
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D016193:G1 Phase / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D009502:Neutrons; D016192:Resting Phase, Cell Cycle / Q000528:radiation effects*