Activities of ABT-773 against microaerophilic and fastidious organisms.
ABT-773 was tested against 317 fastidious isolates; it inhibited 99% of organisms at a concentration of 4.0 microg/ml. With ampicillin-sulbactam and levofloxacin, only 2 and 6% of these strains, respectively, were resistant at the breakpoint. With clindamycin, penicillin G, and metronidazole, 22, 26, and 58% of the strains, respectively, were resistant.
Infectious Diseases Section, VA Greater Los Angeles Healthcare System, West Los Angeles Division, Los Angeles, CA 90073, USA. sidfinegol@aol.com
Sydney M
SM
Finegold
Denise
D
Molitoris
V T
VT
Phan
M-L
ML
Vaisanen
Hannah M
HM
Wexler
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D048628:Ketolides; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D048628:Ketolides; D004917:Erythromycin; C405499:cethromycin