Dental and skeletal stem cells: potential cellular therapeutics for craniofacial regeneration.
The study of stem cells has received considerable attention since the discovery that adult stem cells have the capacity to form many different tissue types. Technical advances have helped identify potential stem cells, and their capacity for regenerating tissues is being studied in transplantation models. Further study of the isolation, nature, and differentiation potential of stem cells will likely have a positive impact on our understanding of human development and regenerative medicine. This review highlights the difference between embryonic and adult stem cells and discusses the potential use of these cells for cellular therapeutics for craniofacial regeneration.
University of Michigan School of Dentistry, Department of Oral Medicine, Pathology and Oncology, Ann Arbor 48109-1078, USA. paulk@umich.edu
Paul H
PH
Krebsbach
Pamela Gehron
PG
Robey
D000328:Adult; D000818:Animals; D001846:Bone Development; D001847:Bone Diseases / Q000628:therapy; D001842:Bone and Bones / Q000166:cytology*; D002454:Cell Differentiation; D002469:Cell Separation; D003739:Dental Cementum / Q000166:cytology; D003782:Dental Pulp / Q000166:cytology; D004622:Embryo, Mammalian; D005145:Face / Q000502:physiology; D005147:Facial Bones / Q000502:physiology; D006128:Growth; D006801:Humans; D008648:Mesoderm / Q000166:cytology; D023421:Models, Animal; D012038:Regeneration / Q000502:physiology; D012886:Skull / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering; D014070:Tooth / Q000166:cytology*