Immunoglobulin levels in methotrexate treated paediatric rheumatology patients.
Retrospective review of serum immunoglobulin levels in 78 methotrexate treated paediatric rheumatology patients showed that IgG, IgA, and IgM levels fell significantly by 26%, 21%, and 17% respectively while on methotrexate. Six patients with systemic disease showed a fall in IgG to below the normal range.
Rackham
O J
OJ
Department of Rheumatology, Alder Hey Children's Hospital, Eaton Road, Liverpool, UK. ojrackham@talk21.com
Sills
J A
JA
Davidson
J E
JE
D018501:Antirheumatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000276:immunology; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000187:drug effects; D007136:Immunoglobulins / Q000097:blood / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008727:Methotrexate / Q000494:pharmacology* / Q000627:therapeutic use; D012189:Retrospective Studies
D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D008727:Methotrexate