Aluminum: impacts and disease.
Aluminum is the most widely distributed metal in the environment and is extensively used in modern daily life. Aluminum enters into the body from the environment and from diet and medication. However, there is no known physiological role for aluminum within the body and hence this metal may produce adverse physiological effects. The impact of aluminum on neural tissues is well reported but studies on extraneural tissues are not well summarized. In this review, the impacts of aluminum on humans and its impact on major physiological systems are summarized and discussed. The neuropathologies associated with high brain aluminum levels, including structural, biochemical, and neurobehavioral changes, have been summarized. In addition, the impact of aluminum on the musculoskeletal system, respiratory system, cardiovascular system, hepatobiliary system, endocrine system, urinary system, and reproductive system are discussed.
Department of Physiology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, 737102, Sikkim, India.
Prasunpriya
P
Nayak
D000535:Aluminum / Q000009:adverse effects* / Q000493:pharmacokinetics; D001921:Brain / Q000473:pathology*; D002318:Cardiovascular Diseases / Q000139:chemically induced; D004032:Diet; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D009140:Musculoskeletal Diseases / Q000139:chemically induced; D009422:Nervous System Diseases / Q000139:chemically induced*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012098:Reproduction / Q000187:drug effects; D012140:Respiratory Tract Diseases / Q000139:chemically induced
D004364:Pharmaceutical Preparations; D000535:Aluminum