New cytotoxic coumarins and prenylated benzophenone derivatives from the bark of Ochrocarpos punctatus from the Madagascar rainforest.
Bioassay-guided fractionation of a CH2Cl2-MeOH extract of the bark of Ochrocarpos punctatus resulted in the isolation of seven new coumarins, ochrocarpins A-G (1-7), three new benzophenone derivatives, ochrocarpinones A-C (8-10), and five known coumarins, mammea A/AC cyclo F (11), mammea A/AD cyclo D (12), mammea A/AB cyclo F (13), mammea A/AA cyclo F (14), mammea A/AB cyclo D (15), and 15,16-dihydro-16-hydroperoxyplukenetione (16). The structures of compounds 1-10 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. All compounds exhibited cytotoxicity against the A2780 ovarian cancer cell line.
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
V S Prakash
VS
Chaturvedula
Jennifer K
JK
Schilling
David G I
DG
Kingston
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028084:Clusiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008270:Madagascar; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D001577:Benzophenones; D003374:Coumarins; C465427:ochrocarpinone A; C465428:ochrocarpinone B; C465429:ochrocarpinone C