In vitro inhibition of gene transcription by novel photo-activated polyazaaromatic ruthenium(II) complexes.
Under visible irradiation, [Ru(TAP)2(phen)]2+(Cl-)2, [Ru(TAP)2(POQ-Nmet)]2+(Cl-)2 and [Ru(bpy)2(phen)]2+(Cl-)2 were able to dramatically reduce the in vitro transcription of a plasmid DNA template by a bacteriophage RNA polymerase. This photoactivity is related to two different mechanisms of reactivity towards DNA exhibited by these complexes under illumination.
Laboratoire de Recherche sur le Cancer et les Maladies du Sang, Avenue de la Faïencerie 162A, L-1511 Luxembourg, Luxembourg.
Marc
M
Pauly
Isabelle
I
Kayser
Martine
M
Schmitz
Mario
M
Dicato
André
A
Del Guerzo
Isabelle
I
Kolber
Cécile
C
Moucheron
Andrée Kirsch-De
AK
Mesmaeker
D001372:Aza Compounds / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry; D010957:Plasmids; D017975:Ruthenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*
D001372:Aza Compounds; D017975:Ruthenium Compounds; D004247:DNA