Photoprotective activity of melanin preparations from black yeast-like fungus during UV irradiation of human skin: dependence on the concentration.
The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum photoprotective effect.
St. Petersburg-Technology, St. Petersburg.
B A
BA
Paramonov
I I
II
Turkovskii
I L
IL
Potokin
V Yu
VY
Chebotarev
D001203:Ascomycota / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D008543:Melanins / Q000302:isolation & purification / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays
D008543:Melanins; D011837:Radiation-Protective Agents