Effect of topical application of fipronil in cats with flea allergic dermatitis.
OBJECTIVE
To determine whether topical application of a 10% fipronil solution would control signs of flea allergic dermatitis in cats housed under natural conditions.


METHODS
Multicenter open clinical trial.


METHODS
42 client-owned cats with flea allergic dermatitis.


METHODS
Study cats along with all other cats and dogs living in the same houses were treated with 10% fipronil solution topically on days 0, 30, and 60. Flea counts and clinical assessments were performed on study cats on days 0, 14, 30, 60, and 90.


RESULTS
Percentage reductions in geometric mean flea counts on days 14, 30, 60, and 90, compared with day-0 geometric mean count, were 75, 73, 85, and 94%, respectively. Pruritus score was significantly improved at each examination after day 0, and pruritus was reduced or eliminated in 31 of 40 (78%) cats at the final examination. Similarly, scores for severity of miliary dermatitis and alopecia were significantly improved at each examination, except for alopecia score on day 14. Overall treatment efficacy, assessed on day 90, was excellent for 28 (70%) cats, good for 6 (15%), moderate for 3 (7.5%), and poor for 3 (7.5%).


CONCLUSIONS
Results suggest that monthly topical application of fipronil is effective for treatment of flea allergic dermatitis in cats housed under natural conditions.
Medleau
Linda
L
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Hnilica
Keith A
KA
Lower
Kimberly
K
Alva
Roberto
R
Clekis
Terry
T
Case
Jerry
J
McArthur
T Reid
TR
Barrick
Ruth Ann
RA
Jeannin
Philippe
P
Irwin
Jennifer
J
D000287:Administration, Topical; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D007300:Insect Control; D007306:Insecticides / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D005423:Siphonaptera / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors; D016896:Treatment Outcome
D007306:Insecticides; D011720:Pyrazoles; C082360:fipronil