Novel thiophene derivatives for the treatment of benign prostatic hyperplasia.
The syntheses and biological activities of a novel series of 2,4- and 2,5-disubstituted thiophenes are reported. These analogues have shown excellent affinity and selectivity against alpha(1)-adrenoreceptor subtypes.
Johnson & Johnson Pharmaceutical Research and Development LLC, Drug Discovery Research, 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA.
Haripada
H
Khatuya
Virginia L
VL
Pulito
Linda K
LK
Jolliffe
Xiaobing
X
Li
William V
WV
Murray
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D006801:Humans; D008297:Male; D015394:Molecular Structure; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D013876:Thiophenes