Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment.
Deletion of both copies of the Nf1 gene in Schwann cells combined with Nf1 heterozygosity in the tumor environment promotes neurofibroma formation in mice.
Howard Hughes Medical Institute, Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
Margaret E
ME
McLaughlin
Tyler
T
Jacks
D000818:Animals; D002471:Cell Transformation, Neoplastic; D017353:Gene Deletion; D016514:Genes, Neurofibromatosis 1 / Q000502:physiology*; D006801:Humans; D019656:Loss of Heterozygosity; D051379:Mice; D008822:Mice, Transgenic; D009455:Neurofibroma / Q000235:genetics*; D012583:Schwann Cells / Q000378:metabolism