Emerging immune targets for the therapy of allergic asthma.
Recent discoveries on the molecular and cellular basis of asthma have markedly altered our understanding of this common respiratory disorder. These insights have come during an unexplained period of rising disease incidence and severity and are now being applied to develop improved therapies. This review explores the latest advances in our understanding of the pathogenesis of allergic asthma, and provides insight into the expanding collaborations between research scientists, clinicians and the pharmaceutical industry in the race to control the asthma epidemic.
Corry
David B
DB
Departments of Medicine and Immunology, Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas 77030, USA. dcorry@bcm.tmc.edu
D001249:Asthma / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D018121:Receptors, Cytokine / Q000502:physiology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines; D018121:Receptors, Cytokine; D011505:Protein-Tyrosine Kinases