New concepts in the pathogenesis of urinary tract infections.
Random amplified polymorphic DNA fingerprinting was used to distinguish among Escherichia coli bacterial strains creating urinary tract infections (UTIs) in women. Bacteria bound more avidly to cells from postmenopausal donors with history of UTIs (PK) compared with cells from women without history of UTIs (AO). Nonpiliated bacterial strains did not adhere to the cell lines. Increasing S-IgA concentrations has no effect on AO cell bacterial binding, whereas bacterial adhesion to PK cell epithelium increased with increasing S-IgA concentration.
Department of Urology (T229), Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA. ajschaeffer@northwestern.edu
Anthony J
AJ
Schaeffer
D001422:Bacterial Adhesion; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019105:Random Amplified Polymorphic DNA Technique; D014552:Urinary Tract Infections / Q000382:microbiology*; D014556:Urine / Q000382:microbiology; D014621:Vagina / Q000382:microbiology* / Q000502:physiology