Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits.
OBJECTIVE
This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants.


RESULTS
Two experimental groups of male New Zealand White rabbits, a control group and a curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower alpha-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days.


CONCLUSIONS
Supplementation with Curcuma longa reduces oxidative stress and attenuates the development of fatty streaks in rabbits fed a high cholesterol diet.
Department of Physiology, Granada University, Granada, Spain.
José L
JL
Quiles
M Dolores
MD
Mesa
César L
CL
Ramírez-Tortosa
Concepción M
CM
Aguilera
Maurizio
M
Battino
Angel
A
Gil
M Carmen
MC
Ramírez-Tortosa
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001018:Aortic Diseases / Q000517:prevention & control*; D001161:Arteriosclerosis / Q000517:prevention & control*; D003067:Coenzymes; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology; D030024:Curcuma / Q000737:chemistry* / Q000378:metabolism; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D036381:Diarylheptanoids; D004036:Diet, Atherogenic; D019587:Dietary Supplements; D008054:Lipid Peroxides / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000627:therapeutic use; D011817:Rabbits; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014801:Vitamin A / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D003067:Coenzymes; D003373:Coumaric Acids; D036381:Diarylheptanoids; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D010936:Plant Extracts; C099252:oxidized low density lipoprotein; D014801:Vitamin A; D014451:Ubiquinone; C034786:bisdemethoxycurcumin; C024989:coenzyme Q10; D024502:alpha-Tocopherol; D003474:Curcumin; C050229:demethoxycurcumin