Reproductive toxicity and infertility effect of Ferula hornonis extracts in mice.
The anti-fertility, anti-implantation, and ovarian histological alterations of the ethanolic extract of Ferula hormonis have been investigated in female mice. The intragastric application of 3 mg/kg per day of such extract for 6 weeks resulted in a significant reduction in female mice fertility. Furthermore, it caused a decrease in the number of mated females, the total number of implantations, and the number of viable fetuses. These changes were also associated with ovarian atrophy and a concomitant increase in the connective tissue. The ova showed degeneration while most of the ovarian follicles suffered follicular atresia.
Homady
Merza H
MH
Department of Biological Sciences, Mu'tah University, Al-Karak, Jordan. merzahh@yahoo.com
Khleifat
Khaled M
KM
Tarawneh
Khaled A
KA
Al-Raheil
Ismael A
IA
D000818:Animals; D001284:Atrophy; D010064:Embryo Implantation / Q000187:drug effects; D000431:Ethanol; D005260:Female; D005309:Ferula / Q000737:chemistry*; D005496:Follicular Atresia / Q000187:drug effects; D007247:Infertility, Female / Q000139:chemically induced*; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D051379:Mice; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects*
D010936:Plant Extracts; D000431:Ethanol