Ikaros: a key regulator of haematopoiesis.
Ikaros is an essential transcription factor for normal lymphocyte development. Because of its interaction with a number of closely related factors, Ikaros is required for correct regulation of differentiation and cell proliferation in T- and B-cell lineages. Interestingly, Ikaros appears to function both as a transcriptional repressor and as an activator through its ability to bind a large number of nuclear factors, including components of both histone deacetylase and ATP-dependent chromatin remodelling complexes. In addition, nuclear localisation is important for Ikaros function--unlike most transcription factors, Ikaros is localised to discrete nuclear foci in lymphoid cells, suggesting it employs novel mechanisms to regulate transcription.
Westman
Belinda J
BJ
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia. b.westman@mmb.usyd.edu.au
Mackay
Joel P
JP
Gell
David
D
D000818:Animals; D004268:DNA-Binding Proteins; D006410:Hematopoiesis / Q000502:physiology*; D051740:Ikaros Transcription Factor; D011487:Protein Conformation; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D051740:Ikaros Transcription Factor