A patient with delayed posthypoxic demyelination: a case report of hyperbaric oxygen treatment.
A 62-year-old man who developed akinetic mutism with delayed white matter demyelination after hypoxia was treated with hyperbaric oxygen (HBO). HBO in the subacute period markedly improved the patient's activity in daily life, cognitive function and organization on EEG. 1H-MRS showed a recovery of aerobic metabolism of the neurons. However, dementia and cerebral atrophy slowly progressed despite HBO treatment. Thus, HBO had a beneficial effect on the activity of depressed neurons but did not improve the prognosis.
Miura
Shiro
S
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.
Ohyagi
Yasumasa
Y
Ohno
Masaharu
M
Inoue
Isao
I
Ochi
Hirofumi
H
Murai
Hiroyuki
H
Furuya
Hirokazu
H
Yamada
Takeshi
T
Kira
Jun-ichi
J
D001284:Atrophy; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000209:etiology; D003711:Demyelinating Diseases / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D000860:Hypoxia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013406:Suicide, Attempted; D016896:Treatment Outcome