Acetazolamide therapy for symptomatic plateau waves in patients with brain tumors. Report of three cases.
In this report, the authors describe three patients with malignant gliomas who experienced paroxysmal neurological symptoms triggered by standing. The symptoms were attributed to acute elevations of intracranial pressure, an uncommon phenomenon called "plateau waves." In each instance, the attacks occurred despite the fact that the patient was receiving dexamethasone therapy and stopped promptly with the addition of acetazolamide. Acetazolamide, an orally administered carbonic anhydrase inhibitor, appears to be a specific and effective therapy for this uncommon neurological disorder.
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada. Chris.Watling@LHSC.ON.CA
Christopher J
CJ
Watling
J Gregory
JG
Cairncross
D000086:Acetazolamide / Q000627:therapeutic use*; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications*; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D005909:Glioblastoma / Q000150:complications*; D006801:Humans; D019586:Intracranial Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged
D004232:Diuretics; D000086:Acetazolamide