Protection and treatment of sensorineural hearing disorders caused by exogenous factors: experimental findings and potential clinical application.
During the last decade, there have been numerous interesting findings regarding the roles of neurotrophins, nitric oxide, reactive oxygen species, glutamate receptors, and shock protein in the auditory system. These findings have provided a scientific basis for the development of techniques to protect the auditory system against trauma as well as for the treatment of peripheral hearing disorders. This review focuses on recent advances in experimental prevention and treatment of hearing impairment which are expected to be of clinical value in the near future. Viral vector and non-viral vector gene therapy and transplantation of stem cells are discussed as potential treatments of irreversible sensorineural inner ear damage.
Institute for Hearing and Communication Research, Karolinska Institutet, Karolinska Hospital, S-171 76, Stockholm, Sweden. maoli.duan@ihk.ki.se
Mao Li
ML
Duan
Mats
M
Ulfendahl
Göran
G
Laurell
S A
SA
Counter
Allen S
AS
Counter
Ilmari
I
Pyykkö
Erik
E
Borg
Ulf
U
Rosenhall
D000818:Animals; D003054:Cochlear Implants; D015316:Genetic Therapy / Q000379:methods; D006317:Hearing Loss, Noise-Induced / Q000517:prevention & control / Q000628:therapy; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D009414:Nerve Growth Factors / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D033581:Stem Cell Transplantation
D009414:Nerve Growth Factors; D017382:Reactive Oxygen Species; D017470:Receptors, Glutamate; D009569:Nitric Oxide