[Searching for the susceptibility loci of psoriasis in Chinese].
OBJECTIVE
To search for the susceptibility genes of patients with psoriasis in Chinese.


METHODS
38 psoriasis families were determined to search for the susceptibility loci by selecting 19 reported polymorphic microsatellite DNA markers and making use of fluorescein-labeled PCR with Mega BACE sequencer.


RESULTS
The significant two-point Lod score values of parametric linkage analysis were obtained with D6S1610 marker (1.18 at theta; = 0.2) and D17S944 marker (1.60 at theta; = 0.1); the NPL values greater than 1.6 (P < 0.05) of non-parametric analysis were obtained with D6S1610 marker, D17S944 marker and D17S785 marker.


CONCLUSIONS
A putative linkage to D6S1610 marker, D17S944 marker and D17S785 marker.
Department of Dermatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025, China.
Shiyi
S
Jin
Ruofei
R
Shi
Jie
J
Zheng
D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics*