The presence of cytokine (IL-8, IL-1alpha, IL-1beta)-producing cells in inflamed gingival tissue from a patient manifesting Papillon-Lefevre syndrome(PLS).
The point of this study was to examine the presence or absence of cytokine-positive cells by means of immunohistochemical methods in the samples of inflamed gingival tissues obtained from an 11-year-old girl with Papillon-Lefevre syndrome (PLS). Interleukin-8 (IL-8)-positive cells were found to be present. In addition, IL-1alpha-and IL-1beta-positive cells were detected. No dysfunction in the phagocytosis and the bacterial killing of peripheral blood polymorphonuclear neutrophils (PMNs) was observed in this patient. Our findings suggest that these cytokines may be members responsible for modulating the process of rapidly progressive periodontitis for patient with PLS.
Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, 812-8582, Japan.
Hiroaki
H
Kabashima
Masahiro
M
Yoneda
Kengo
K
Nagata
Kazuaki
K
Nonaka
Takao
T
Hirofuji
Katsumasa
K
Maeda
D010520:Aggressive Periodontitis / Q000276:immunology* / Q000473:pathology; D001770:Blood Bactericidal Activity; D002648:Child; D005260:Female; D005881:Gingiva / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D016209:Interleukin-8 / Q000096:biosynthesis*; D009504:Neutrophils / Q000276:immunology; D010214:Papillon-Lefevre Disease / Q000276:immunology* / Q000473:pathology; D010587:Phagocytosis
D007375:Interleukin-1; D016209:Interleukin-8