High diastereoselectivity in intermolecular carbonyl ylide cycloaddition with aryl aldehyde using methyl diazo(trifluoromethyl)acetate.
[reaction: see text] Methyl diazo(trifluoromethyl)acetate undergoes Rh2(OAc)4 catalyzed reaction with aryl aldehyde to form 1,3-dioxolanes bearing a C-4 trifluoromethyl group diastereoselectively in excellent yield.
Jiang
Biao
B
The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China. jiangb@pub.sioc.ac.cn
Zhang
Xiaobing
X
Luo
Zhaohui
Z