Ikaros: a key regulator of haematopoiesis.
Ikaros is an essential transcription factor for normal lymphocyte development. Because of its interaction with a number of closely related factors, Ikaros is required for correct regulation of differentiation and cell proliferation in T- and B-cell lineages. Interestingly, Ikaros appears to function both as a transcriptional repressor and as an activator through its ability to bind a large number of nuclear factors, including components of both histone deacetylase and ATP-dependent chromatin remodelling complexes. In addition, nuclear localisation is important for Ikaros function--unlike most transcription factors, Ikaros is localised to discrete nuclear foci in lymphoid cells, suggesting it employs novel mechanisms to regulate transcription.
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia. b.westman@mmb.usyd.edu.au
Belinda J
BJ
Westman
Joel P
JP
Mackay
David
D
Gell
D000818:Animals; D004268:DNA-Binding Proteins; D006410:Hematopoiesis / Q000502:physiology*; D051740:Ikaros Transcription Factor; D011487:Protein Conformation; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D051740:Ikaros Transcription Factor