Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents.
Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5' side guanine of 5'-GG-3' site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.
Toshima
Kazunobu
K
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp
Takano
Ryusuke
R
Ozawa
Tomohiro
T
Matsumura
Shuichi
S
D001345:Autoradiography; D002241:Carbohydrates / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004341:Drug Evaluation; D004591:Electrophoresis, Polyacrylamide Gel; D006868:Hydrolysis; D010777:Photochemistry; D011810:Quinoxalines / Q000737:chemistry*
D002241:Carbohydrates; D011810:Quinoxalines; D004247:DNA