Ion channels: recent progress and prospects.
Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 A resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.
Department of Theoretical Physics, Research School of Physical Sciences, Australian National University, Canberra, ACT 0200, Australia. shin-ho.chung@anu.edu.au
Shin-Ho
SH
Chung
Serdar
S
Kuyucak
D015220:Calcium Channels / Q000737:chemistry*; D003198:Computer Simulation; D003460:Crystallization; D018360:Crystallography, X-Ray; D004058:Diffusion; D007473:Ion Channels / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D015221:Potassium Channels / Q000737:chemistry*; D013329:Structure-Activity Relationship
D015220:Calcium Channels; D007473:Ion Channels; D015221:Potassium Channels