Can mumps vaccine induce remission in recurrent respiratory papilloma?
OBJECTIVE
To describe our experience using laser excision and locally injected mumps vaccine to induce remission in patients with recurrent respiratory papilloma (RRP).


METHODS
Tertiary care regional medical center.


METHODS
Initially, 11 children with RRP treated in a pilot study with laser excision at regular intervals for at least a year without adjuvant therapy; later, a series of 18 children and 20 adults with RRP, some of whom had used various adjuvant therapy with interval laser excision.


METHODS
Both patient groups continued their same interval laser excision with the same or similar laser, same clinical setting, and same surgeon. Locally injected mumps vaccine was then administered into the excision site after each laser removal of papilloma.


METHODS
Larynx and trachea were microphotographed with each treatment. Two consecutive disease-free intervals and a follow-up of at least 1 year were required criteria for remission.


RESULTS
In the pilot study, remission was induced in 9 (82%) of 11 patients by 1 to 10 injections, with follow-up of 5 to 19 years. In the subsequent series, remission was induced in 29 (76%) of 38 patients by 4 to 26 injections, and follow-up was 2 to 5 years.


CONCLUSIONS
Combined with serial laser excision, mumps vaccine positively influences induction of remission in children with RRP. The mechanisms of this effect are unclear, but the treatment is readily available, inexpensive, and has a low risk of adverse effects.
Presbytarian/St Luke's Hospital, Denver, CO, USA. npashley@aol.com
Nigel R T
NR
Pashley
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000628:therapy*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009108:Mumps Vaccine / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010212:Papilloma / Q000628:therapy*; D053918:Papillomavirus Vaccines; D010865:Pilot Projects; D012074:Remission Induction
D009108:Mumps Vaccine; D053918:Papillomavirus Vaccines