Polyclonal antibody-catalysed hydrolysis of a beta-lactam.
We report the first example of antibody-catalysed hydrolysis of a beta-lactam where the antibodies were generated by a simple transition-state analogue; in this example the antibodies are polyclonal.
Ostler
Elizabeth L
EL
School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, UK BN2 4GJ.
Resmini
Marina
M
Boucher
Guillaume
G
Romanov
Nickolas
N
Brocklehurst
Keith
K
Gallacher
Gerard
G
D017151:Antibodies, Catalytic / Q000737:chemistry*; D002384:Catalysis; D006868:Hydrolysis; D047090:beta-Lactams / Q000737:chemistry*
D017151:Antibodies, Catalytic; D047090:beta-Lactams