First synthesis of (+)-alpha- and (+)-gamma-polypodatetraenes.
First synthesis of (+)-alpha-polypodatetraene (1) and (+)-gamma-polypodatetraene (2) was achieved from (+)-albicanol (6) and (-)-drimenol (8), respectively. The absolute structure of natural (+)-2 was established to be (5S,9S,10S)-polypoda-7,13(E),17(E),21-tetraene.
School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.
Masako
M
Kinoshita
Mahisa
M
Ohtsuka
Daisuke
D
Nakamura
Hiroyuki
H
Akita
D005030:Ethylenes / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry; D014315:Triterpenes / Q000138:chemical synthesis*
D005030:Ethylenes; D007202:Indicators and Reagents; D009281:Naphthalenes; D012717:Sesquiterpenes; D014315:Triterpenes; C438910:albicanol