Interfacial tensile strength between polymethylmethacrylate-based bioactive bone cements and bone.
We have developed two types of polymethylmethacrylate (PMMA)-based bioactive bone cements containing bioactive glass beads (designated GBC) or apatite-wollastonite containing glass-ceramic powder (designated AWC) as the filler. A new method was used to evaluate the bone-cement interfacial strength of these bioactive bone cements. Two types of bioactive bone cements (GBC and AWC) and PMMA cement (CMW-1) were put in a frame attached to the smooth tibial metaphyseal cortex of the rabbit and polymerized in situ. The load required to detach the cement from the bone was measured at 4, 8, and 16 weeks after implantation. The interfacial tensile strength of GBC and AWC showed significantly higher values than PMMA cement from 4 weeks, and increased with time. For GBC, strength reached a maximum value of 12.39 +/- 1.79 kgf 16 weeks after implantation. Histological examination of rabbit tibiae up to 16 weeks demonstrated no intervening layer between the bioactive bone cements and the bone, whereas fibrous tissue was observed at the interface between the PMMA cement and the bone. From this study, we conclude that PMMA-based bioactive bone cements have a relatively higher adhesiveness at the interface than the conventionally used PMMA cement, showing potential as a promising alternative.
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Masaki
M
Kamimura
Jiro
J
Tamura
Shuichi
S
Shinzato
Keiichi
K
Kawanabe
Masashi
M
Neo
Tadashi
T
Kokubo
Takashi
T
Nakamura
D000818:Animals; D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D001843:Bone Cements / Q000737:chemistry* / Q000378:metabolism; D002516:Ceramics / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D011208:Powders; D019736:Prostheses and Implants; D011817:Rabbits; D012824:Silicic Acid / Q000737:chemistry; D013718:Tensile Strength; D013977:Tibia / Q000033:anatomy & histology / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D013997:Time Factors
D001031:Apatites; D001672:Biocompatible Materials; D001843:Bone Cements; D011208:Powders; C077777:apatite-wollastonite-containing glass ceramic; D012824:Silicic Acid; D019904:Polymethyl Methacrylate