[Production of bacteriocins by gram-positive bacteria and the mechanisms of transcriptional regulation].
The mechanisms of production of bacteriocins in Gram-positive bacteria and the main distinctions of these bacteriocins from the bacteriocins of Gram-negative bacteria (colicins) are outlined. A classification of antibacterial peptides is presented, and most of known class I and II peptides are pointed out. In Gram-positive bacteria, the cases of bacteriocin-associated quorum sensing are examined. For these cases, the structure of loci containing the genes of regulatory systems, transport, immunity, processing, and posttranslational modification of antibacterial peptides are described. All known regulatory sites for class II bacteriocins are presented. A description of the putative regulatory sites found by us and their classification are provided. The evolutionary tree of transcriptional response regulators is shown to correspond to the tree of their recognition sites.
State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 113545 Russia. kkot2001@yandex.ru
E A
EA
Kotel'nikova
M S
MS
Gel'fand
D001430:Bacteriocins / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D005075:Biological Evolution; D015964:Gene Expression Regulation, Bacterial; D005809:Genes, Regulator; D006094:Gram-Positive Bacteria / Q000235:genetics* / Q000378:metabolism*; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic
D001430:Bacteriocins