[Dependence of galodif pharmacokinetics on duration of its administration].
Pharmacokinetics of the new antiepileptic drug galodif was experimentally studied on rats. A single administration of the anticonvulsant is followed by slow elimination. A five-day administration leads to a significant acceleration of the drug elimination due to activation of the cytochrome P-450 dependent monooxygenase system of liver. After a 14-day administration, the elimination rate decreases as compared to that for the five-day treatment, while being still higher than in the case of single administration.
Kanov
E V
EV
Institute of Psychological Health, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Sosnovyi Bor, Tomsk, 634014 Russia.
Novozheeva
T P
TP
Saratikov
A S
AS
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010671:Phenylurea Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D051381:Rats
D000927:Anticonvulsants; D010671:Phenylurea Compounds; C068164:galodif