[Effects of dehydroepiandrosterone on passive avoidance in ovariectomized female rats of different age].
The aim of the present work was to study the influence of long-term treatment with dehydroepiandrosterone (DHEA) in doses of 0.1 and 0.7 mg/kg, i.p. on the passive avoidance performance in the ovariectomized female rats of 5- and 18-month old. The results obtained indicated that DHEA administration during 7 days in dose of 0.1 mg/kg normalized the passive avoidance performance in the ovariectomized rats of 5-month old while DHEA administration during 7 days in dose of 0.7 mg/kg restored passive avoidance performance in the ovariectomized rats of 18-month old.
Institute for Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
N P
NP
Goncharov
Iu O
IuO
Fedotova
N S
NS
Sapronov
D000367:Age Factors; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D010052:Ovariectomy; D051381:Rats
D003687:Dehydroepiandrosterone