Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy.
This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, -30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 +/- 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.
Briellmann
Regula S
RS
Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia.
Berkovic
Samuel F
SF
Syngeniotis
Ari
A
King
Mark A
MA
Jackson
Graeme D
GD
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D012640:Seizures / Q000473:pathology*