Disappearance of central thalamic pain syndrome after contralateral parietal lobe lesion: implications for therapeutic brain stimulation.
At present there is hardly any appropriate therapy for central pain syndromes available. We report on a unique case of a central thalamic pain syndrome that did not respond to any therapy but disappeared after an additional contralateral parietal lobe lesion. This example indicates that lesions affecting the bilateral balance of thalamo-parietal circuits may lead to pain relief in patients with central pain syndrome, which probably constitutes a bilateral disorder of functional plasticity. This should be taken into account in chronic brain stimulation for persistent pain states.
Department of Neurology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany Department of Anesthesiology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany Department of Neuroradiology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany Department of Neurosurgery, University of Heidelberg, Germany.
C
C
Helmchen
M
M
Lindig
D
D
Petersen
V
V
Tronnier
D004599:Electric Stimulation Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D010146:Pain / Q000473:pathology; D059408:Pain Management; D017288:Pain Threshold / Q000502:physiology; D010296:Parietal Lobe / Q000473:pathology* / Q000502:physiology; D013577:Syndrome; D013788:Thalamus / Q000473:pathology* / Q000502:physiology