Functional architecture of primate cone and rod axons.
The cone axon is nearly four times thicker than the rod axon (1.6 vs 0.45 microns diameter). To assess how signal transfer and integration at the terminal depend on cable dimensions, a transducer (cone = ohmic conductance, rod = current source) coupled via passive cable to a sphere with a chloride conductance (representing GABAA receptor) was modelled. For a small signal in peripheral cone with a short axon, steady photosignal transfers independently of axon diameter despite a significant chloride conductance at the cone terminal. Temporally varying photosignal also transfers independently of axon diameter up to 20 Hz and is attenuated only 20% at 50 Hz. Thus, to accomplish the basic electrical functions of a peripheral cone, a thin axon would suffice. For a foveal cone with a long axon steady photosignal transfers independently of axon diameter, but temporally varying photosignal is attenuated 5-fold at 50 Hz for a thick axon and 10-fold for a thin axon. This might contribute to the lower sensitivity of central retina to high temporal frequencies. The cone axon contains 14-fold more microtubules than the rod axon, and its terminal contains at least 20-fold more ribbon synapses than the rod's. Since ribbon synapses sustain high rates of exocytosis, the additional microtubules (which require a thicker axon) may be needed to support a greater flux of synaptic vesicle components.
Department of Neuroscience, 123 Anatomy-Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6058, USA.
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Hsu
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Tsukamoto
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Smith
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Sterling
D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D003198:Computer Simulation; D008251:Macaca; D008252:Macaca fascicularis; D008870:Microtubules / Q000648:ultrastructure; D008959:Models, Neurological; D009446:Neurobiology; D012160:Retina / Q000648:ultrastructure*; D017949:Retinal Cone Photoreceptor Cells / Q000648:ultrastructure; D017948:Retinal Rod Photoreceptor Cells / Q000648:ultrastructure