The psychopathological phenotype of velo-cardio-facial syndrome.
Velo-cardio-facial syndrome (VCFS) is mostly associated with deletions of chromosome 22q11, and is thought to be characterized by an increased frequency of major psychiatric disorders. Sixteen patients adults with VCFS and psychiatric symptoms were evaluated using a semi-structured investigation of history, symptoms, signs and behaviour. All available data were used in consensus meetings to obtain a classifiable diagnostic category. In contrast to other reports, no categorical diagnosis could be established. Instead, a quite specific psychological, behavioural and psychopathological constellation emerged that should most adequately be denominated as a VCFS-psychiatric syndrome. It is concluded that VCFS is associated with a specific psychopathological syndrome.
Center for Human Genetics, University Hospital, Leuven, Belgium
A
A
Vogels
W M A
WM
Verhoeven
S
S
Tuinier
K
K
DeVriendt
A
A
Swillen
L M G
LM
Curfs
J P
JP
Frijns
D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002892:Chromosomes, Human, Pair 22; D005145:Face / Q000002:abnormalities*; D005260:Female; D005824:Genetics, Behavioral; D006330:Heart Defects, Congenital / Q000235:genetics / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011618:Psychotic Disorders / Q000235:genetics / Q000473:pathology*; D013577:Syndrome; D014681:Velopharyngeal Insufficiency / Q000235:genetics / Q000473:pathology*