Langerhans cells within the follicular epithelium and the intradermal sweat duct in equine insect hypersensitivity "Kasen".
Histopathologic and electron microscopic observations were given on Langerhans cells (LCs) within the follicular epithelium (FE) and intradermal sweat duct (ISD) of equine "Kasen". By light microscopy, LCs were present in the greatest numbers within the FE and ISD than within the epidermal layer and the normal skin, with an occasional formation of several aggregated foci. By electron microscopy, LCs within the FE and ISD widely extended their dendritic processes between the keratinocytes and contained Birbeck granules (Bgs), mitochondria, rough endoplasmic reticula and ribosomes in the cytoplasm. Numerous Type 2 LCs, with a number of Bgs and endocytosis, and Type 3 LCs, with multivesicular bodies and endosomes of various sizes, were recognized within the FE and ISD, although inactive Type 1 LCs, with a narrow and lucid cytoplasm, were rarely seen. LCs observed within the FE and ISD in the "Kasen" skin lesions might express the particular stage corresponded to recognize, intake and process the antigens which permeate them.
The Kitasato Institute, Saitama, Japan.
Tetsuro
T
Kurotaki
Kazuya
K
Narayama
Yasuko
Y
Arai
Setsuo
S
Arai
Toshifumi
T
Oyamada
Hiroyasu
H
Yoshikawa
Takashi
T
Yoshikawa
D000818:Animals; D004848:Epithelium / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D006734:Horse Diseases / Q000276:immunology / Q000473:pathology*; D006736:Horses; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D013545:Sweat Glands / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure