[Anti-interferon activity of peripheral blood leukocytes in patients infected with HIV-1].
The study was aimed at anti-interferon activity of different components of the in vitro system cells MT-4--HIV-1 as well as the culture fluid of peripheral blood leukocytes from patients at different stages of HIV infection and from patients with mixed infection (HIV and chronic hepatitis C) in comparison with patients infected with hepatitis C virus alone and healthy persons. Anti-interferon activity was detected in all groups of patients, its detection rate varying within 33% and 68%. The tendency towards increased detection rate of anti-interferon activity in HIV-infected patients in parallel with decreased number of CD4+ lymphocytes was noted. These data made it possible to suggest that increased detection rate of anti-interferon activity in the culture fluid of peripheral blood leukocytes from HIV-infected patients in parallel with decreased number of CD4+ lymphocytes could result from pathogenetic processes in the body, leading to a decrease in therapy effectiveness of HIV-infected patients with the preparations of alpha-interferon, especially in patients with a low content of CD4+ cells.
Selimova
L M
LM
Ivanovsky Institute of Virology, Russian Federal Scientific and Methodological Center for Prevention and Control of AIDS, Moscow, Russia.
Serebrovskaia
L V
LV
Kravchenko
A V
AV
Khanina
T A
TA
Maksimov
S L
SL
Kanestri
V G
VG
Pokrovskiĭ
V V
VV
Bobkov
A F
AF
D000998:Antiviral Agents / Q000494:pharmacology; D018791:CD4 Lymphocyte Count; D002478:Cells, Cultured; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000187:drug effects; D019698:Hepatitis C, Chronic / Q000150:complications / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000032:analysis / Q000276:immunology* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000276:immunology*
D000998:Antiviral Agents; D016898:Interferon-alpha