Synthesis of betaglycan-type tetraosyl hexapeptide: a possible precursor regulating enzymatic elongation toward heparin.
TETRAOSYL HEXAPEPTIDE, A PART OF THE SEQUENCE OF BETAGLYCAN: beta-D-GlcA-(1-->3)-beta-D-Gal-(1-->3)-beta-D-Gal-(1-->4)-beta-D-Xyl-(1-->O-SerGlyTrpProAspGly (1), which was designed as a probe for glycan elongation toward heparin, was synthesized in a stereocontrolled manner.
Department of Environmental Sciences, Faculty of Education & Regional Sciences, Tottori University, Japan. jtamura@fed.tottori-u.ac.jp
Jun-ichi
J
Tamura
Akihiro
A
Yamaguchi
Junko
J
Tanaka
D002240:Carbohydrate Sequence; D006493:Heparin / Q000096:biosynthesis*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D011509:Proteoglycans / Q000737:chemistry*; D018125:Receptors, Transforming Growth Factor beta / Q000737:chemistry*; D013237:Stereoisomerism
D009842:Oligopeptides; D011509:Proteoglycans; D018125:Receptors, Transforming Growth Factor beta; C071736:betaglycan; D006493:Heparin