N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus.
In this report we describe a new family of N-thiolated beta-lactams that have antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The compounds show unprecedented structure-activity features and an unusual mode of action for a beta-lactam antibiotic.
Turos
Edward
E
Department of Chemistry, 4202 E. Fowler Avenue, University of South Florida, Tampa, FL 33620, USA. eturos@chuma.cas.usf.edu
Long
Timothy E
TE
Konaklieva
Monika I
MI
Coates
Cristina
C
Shim
Jeung Yeop
JY
Dickey
Sonja
S
Lim
Daniel V
DV
Cannons
Andrew
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams