The ups and downs of daily life: profiling circadian gene expression in Drosophila.
Circadian rhythms are responsible for 24-hour oscillations in diverse biological processes. While the central genes governing circadian pacemaker rhythmicity have largely been identified, clock-controlled output molecules responsible for regulating rhythmic behaviors remain largely unknown. Two recent reports from McDonald and Rosbash(1) and Claridge-Chang et al.2 address this issue. By identifying a large number of genes whose mRNA levels show circadian oscillations, the reports provide important new information on the biology of circadian rhythm. In addition, the reports illustrate both the power and limitations of microarray-based methods for profiling mRNA expression on a genomic scale.
Etter
Paul D
PD
Department of Molecular and Cellular Biology and ARL Division of Neurobiology, Box 210106, Life Sciences South Building, University of Arizona, Tucson, Arizona, USA. pdetter@u.arizona.edu
Ramaswami
Mani
M
D000818:Animals; D002940:Circadian Rhythm; D004331:Drosophila melanogaster / Q000235:genetics*; D016678:Genome; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors
D012333:RNA, Messenger