Mistargeting hippocampal axons by expression of a truncated Eph receptor.
Topographic mapping of axon terminals is a general principle of neural architecture that underlies the interconnections among many neural structures. The Eph family tyrosine kinase receptors and their ligands, the ephrins, have been implicated in the formation of topographic projection maps. We show that multiple Eph receptors and ligands are expressed in the hippocampus and its major subcortical projection target, the lateral septum, and that expression of a truncated Eph receptor in the mouse brain results in a pronounced alteration of the hippocamposeptal topographic map. Our observations provide strong support for a critical role of Eph family guidance factors in regulating ontogeny of hippocampal projections.
Yue
Yong
Y
Department of Chemical Biology, College of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Chen
Zhi-Yong
ZY
Gale
Nick W
NW
Blair-Flynn
Jan
J
Hu
Tian-Jing
TJ
Yue
Xin
X
Cooper
Margaret
M
Crockett
David P
DP
Yancopoulos
George D
GD
Tessarollo
Lino
L
Zhou
Renping
R
D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D019556:COS Cells; D002522:Chlorocebus aethiops; D036383:Ephrin-A2; D036384:Ephrin-A3; D036386:Ephrin-A5; D005326:Fetal Proteins / Q000096:biosynthesis / Q000378:metabolism*; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D036122:Receptor, EphA4; D036123:Receptor, EphA5; D036141:Receptor, EphA7; D014157:Transcription Factors / Q000378:metabolism
D036383:Ephrin-A2; D036384:Ephrin-A3; D036386:Ephrin-A5; D005326:Fetal Proteins; D008024:Ligands; D008565:Membrane Proteins; D014157:Transcription Factors; D020794:Receptor Protein-Tyrosine Kinases; D036122:Receptor, EphA4; D036123:Receptor, EphA5; D036141:Receptor, EphA7