Do triglycerides modulate the effectiveness of clozapine?
We describe a case in which a patient's clinical response to clozapine appears to correlate positively with his serum triglyceride concentrations. We propose that the observed clinical response may partly be the result of the physical interaction of clozapine with the very low-density lipoproteins. We base this supposition on our previous in-vitro study showing that the plasma distribution of clozapine is significantly altered by increases in plasma triglyceride concentrations. Although this case only represents one patient, it highlights the possibility that serum lipids may be potential contributors to the clinical effectiveness of clozapine.
Division of Medical Services, Riverview Hospital, Port Coquitlam, BC, Canada.
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S
Pande
R M
RM
Procyshyn
M
M
Nazerali
D
D
Attwood
K
K
Chow
D000328:Adult; D014150:Antipsychotic Agents / Q000097:blood / Q000627:therapeutic use*; D003024:Clozapine / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D014280:Triglycerides / Q000097:blood*
D014150:Antipsychotic Agents; D014280:Triglycerides; D003024:Clozapine