[Comparative study of dilceren (nimodipine) on the cerebral circulation in the intact animals and animals subjected to ischemic brain damage].
The influence of the calcium entry blocker dilceren (nimodipine) on the local and regional circulation was studied in rats and cats. In the majority of experiments on intact animals, dilceren increased the local and regional blood flow. However, in some cases, the circulation decreased or remained unchanged, which was accompanied by pronounced hypotension. Administered after global brain ischemia, dilceren improved the cerebral hemodynamics in all experiments.
Laboratory of Pharmacology of Cerebrovascular Disorders, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
V V
VV
Aleksandrin
N A
NA
Khaĭlov
G R
GR
Mirzoian
T S
TS
Gan'shina
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D009553:Nimodipine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D009553:Nimodipine