Involvement of superoxide in pathogenic action of mutations that cause Alzheimer's disease.
Mattson
Mark P
MP
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA.
D000375:Aging; D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics; D006624:Hippocampus / Q000166:cytology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007150:Immunohistochemistry; D050356:Lipid Metabolism; D008564:Membrane Potentials; D051379:Mice; D008822:Mice, Transgenic; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D010100:Oxygen / Q000378:metabolism; D016716:PC12 Cells; D051381:Rats; D013481:Superoxides / Q000378:metabolism*; D014466:Ultraviolet Rays
D016564:Amyloid beta-Protein Precursor; D002868:Chromosomal Proteins, Non-Histone; D013481:Superoxides; D006861:Hydrogen Peroxide; D010100:Oxygen