Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation.
Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.
Shim
Joong Sup
JS
Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Kunja-dong, Kwangjin-gu, 143-747, Seoul, South Korea
Kim
Dong Hoon
DH
Jung
Hye Jin
HJ
Kim
Jin Hee
JH
Lim
Dongyeol
D
Lee
Seok-Ki
SK
Kim
Kyu-Won
KW
Ahn
Jong Woong
JW
Yoo
Jong-Shin
JS
Rho
Jung-Rae
JR
Shin
Jongheon
J
Kwon
Ho Jeong
HJ
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018919:Neovascularization, Physiologic / Q000187:drug effects
D020533:Angiogenesis Inhibitors; D006834:Hydrazines; C475807:hydrazinocurcumin; D003474:Curcumin