Leptin, ghrelin, and energy metabolism of the spawning burbot (Lota lota, L.).
The aim of this study was to investigate the energy metabolism of the burbot (Lota lota, n=38) before, during, and after spawning, which represents the greatest annual metabolic demand for the species. A decrease in body mass, relative weight of the livers, and glycogen concentration of the livers was observed toward the end of spawning. The prespawning period was characterized by high rates of liver glycogenolysis and lipid mobilization. Also, plasma triiodothyronine and sex steroid levels were high before reproduction. During spawning, liver lipolysis was reduced and muscle glycogenolysis stimulated. The levels of triiodothyronine and sex steroids decreased. After reproduction, liver glycogenolysis was suppressed and the rate of gluconeogenesis increased. Thyroid hormone levels were elevated after spawning. Leptin protein and a ghrelin-immunoreactive peptide were detected in burbot plasma. Their concentrations were relatively low before and during reproduction but increased after spawning. The functions of leptin and the ghrelin-immunoreactive peptide in the physiology of the burbot are not consistent with the models of their function in mammals.
Mustonen
Anne-Mari
AM
Department of Biology, University of Joensuu, FIN-80101 Joensuu, Finland. ammusto@cc.joensuu.fi
Nieminen
Petteri
P
Hyvärinen
Heikki
H
D000818:Animals; D015992:Body Mass Index; D001835:Body Weight; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005399:Fishes / Q000502:physiology*; D054439:Ghrelin; D006003:Glycogen / Q000378:metabolism; D020738:Leptin / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D036361:Peptide Hormones; D010455:Peptides / Q000494:pharmacology*; D012098:Reproduction / Q000502:physiology*
D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones; D010455:Peptides; D006003:Glycogen