A specific anti-aggressive effect of repeatedly administered lobeline.
The effects of chronic treatments with nicotinic agonists on agonistic encounters have received little attention. The effects of repeated (for 10 days) SC administration of (-)-lobeline (9.3, 18.6 and 37.2 micromol/kg) and (-)-nicotine (0.93, 1.86 and 3.72 micromol/kg) were evaluated using the mouse isolation-induced aggression model. Individually housed OF1 male mice served as experimental animals and were confronted by 'standard opponents'. Each mouse was tested only once on the last day of the repeated drug treatment. Videotaped agonistic encounters were analysed estimating the times allocated to 11 behavioural categories. Repeated treatment with the highest dose of lobeline diminished attack behaviour without significantly increasing immobility or changing any other behavioural category involving motor activity. In contrast, nicotine did not significantly alter time allocated to any behavioural category.
Area de Psicobiología, Facultad de Psicología, Universitat de València, Spain. Rosa.Redolat@uv.es
Rosa
R
Redolat
M Carmen
MC
Oterino
M Carmen
MC
Carrasco
Paul F
PF
Brain
D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D008120:Lobeline / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000494:pharmacology*; D012934:Social Isolation
D018722:Nicotinic Agonists; D009538:Nicotine; D008120:Lobeline