Effect of narcotic pain reliever on pulp tests in women.
The purpose of this study was to determine the effect of one dose of a common narcotic-based pain reliever (Vicodin) on a battery of oral sensitivity tests across time in women. Fifteen Caucasian women randomly were given an oral dose of 10 mg of hydrocodone/1000 mg of acetaminophen or placebo in a double-blind, cross-over design. At baseline (before drug) and after 2, 4, and 8 h each subject was evaluated for sensitivity thresholds with four tests around an experimental tooth: (a) electric pulp tester applied to exposed root; (b) electric pulp tester on adjacent mucosa; (c) increasing probe pressure (grams) on adjacent mucosa; and (d) decreasing cold probe (degrees C) on the exposed root. The outcomes of all tests were not statistically different between drug and placebo treatments at any time point (p > 0.05). These results suggest that a systemic dose of hydrocodone/acetaminophen has little impact on healthy pulp or mucosa sensitivity in women as measured by common diagnostic tests.
Kardelis
Anthony C
AC
Department of Surgical Specialties, University of Nebraska Medical Center College of Dentistry, Lincoln 68583-0757, USA.
Meinberg
Trudy A
TA
Sulte
Heather R
HR
Gound
Tom G
TG
Marx
David B
DB
Reinhardt
Richard A
RA
D000082:Acetaminophen / Q000008:administration & dosage*; D000284:Administration, Oral; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D003080:Cold Temperature; D018592:Cross-Over Studies; D003791:Dental Pulp Test / Q000379:methods; D004311:Double-Blind Method; D004338:Drug Combinations; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D006853:Hydrocodone / Q000008:administration & dosage*; D008875:Middle Aged; D017288:Pain Threshold / Q000187:drug effects*; D014098:Toothache / Q000517:prevention & control*
D000701:Analgesics, Opioid; D004338:Drug Combinations; C083640:acetaminophen, hydrocodone drug combination; D000082:Acetaminophen; D006853:Hydrocodone