Absolute level of Epstein-Barr virus DNA in human immunodeficiency virus type 1 infection is not predictive of AIDS-related non-Hodgkin lymphoma.
To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome-related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level.
Department of Clinical Viro-Immunology, Sanquin Research at CLB, and Department of Hematology, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands. D_van_Baarle@clb.nl
Debbie
D
Van Baarle
Katja C
KC
Wolthers
Egbert
E
Hovenkamp
Hubert G M
HG
Niesters
Albert D M E
AD
Osterhaus
Frank
F
Miedema
Marinus H J
MH
Van Oers
D004279:DNA, Viral / Q000097:blood*; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D015497:HIV-1 / Q000254:growth & development*; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000254:growth & development; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D008137:Longitudinal Studies; D016483:Lymphoma, AIDS-Related / Q000097:blood / Q000821:virology*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000821:virology*; D008297:Male; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D019562:Viral Load
D004279:DNA, Viral