Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity.
The aim of this study was to investigate the production of HSP70 in gastrocnemius muscles from adult (6-month-old) and aged (28-month-old) rats following contractile activity. At 24 h following a period of repeated isometric contractions, muscles from adult rats contained significantly elevated levels of HSP70 compared with nonexercised muscle. This was not evident in muscles from aged rats. This attenuated response may play a major role in development of the age-related functional deficit that occurs in skeletal muscle.
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK.
Aphrodite
A
Vasilaki
Malcolm J
MJ
Jackson
Anne
A
McArdle
D000375:Aging / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D004558:Electric Stimulation; D005260:Female; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D007537:Isometric Contraction / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; C494373:Hspa8 protein, rat