Novel alpha-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416. I. Taxonomy, fermentation and isolation.
New alpha-glucosidase inhibitors, CKD-711 and CKD-711a were produced from the fermentation broth of Streptomyces sp. CK-4416 which was isolated from a forest soil of Jeju Island, South Korea. CKD-711 and CKD-711a were purified by Dowex 50W-2X and Sephadex G-10 column chromatography. In in vitro studies, CKD-711 showed a potent inhibitory activity against a-glucosidase from mammalian, but less inhibition against a-amylase from microorganism and mammalian. CKD-711a showed a lower inhibitory activity than CKD-711.
CKD Research Institute, Chonan, Korea.
Jong-Gwan
JG
Kim
Hung-Bae
HB
Chang
Young-In
YI
Kwon
Seung-Kee
SK
Moon
Hyoung-Sik
HS
Chun
Soon Kil
SK
Ahn
Chung Il
CI
Hong
D000818:Animals; D003470:Culture Media; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000378:metabolism; D005285:Fermentation; D065089:Glycoside Hydrolase Inhibitors; D008855:Microscopy, Electron, Scanning; D051381:Rats; D012988:Soil Microbiology; D013302:Streptomyces / Q000145:classification* / Q000254:growth & development / Q000378:metabolism*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
D003470:Culture Media; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D000516:alpha-Amylases