Signaling the pathway to regeneration.
Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.
Neuroscience Center, University of North Carolina, Chapel Hill 27599, USA. wsnider@med.unc.edu
William D
WD
Snider
Feng-Quan
FQ
Zhou
Jian
J
Zhong
Annette
A
Markus
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology / Q000293:injuries / Q000378:metabolism; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*
D016207:Cytokines; D006133:Growth Substances; D000242:Cyclic AMP