Neuroregulative mechanism of hypothalamic paraventricular nucleus on gastric ischemia-reperfusion injury in rats.
A rat model of gastric ischemia-reperfusion injury (GI-RI) was established by clamping the celiac artery for 30 min and allowing reperfusion for 1 h, on which the regulatory effect of the paraventricular nucleus (PVN) and its neural mechanisms were investigated. The results were: 1. Electrical stimulation of the PVN obviously attenuated the GI-RI. Microinjection of L-glutamic acid into PVN produced an effect similar to that of PVN stimulation. 2. Electrolytic ablation of the PVN aggravated the GI-RI. 3. Nucleus tractus solitarius (NTS) ablation could eliminate the protective effect of electrical stimulation of PVN on GI-RI. 4. Hypophysectomy did not alter the effect of electrical stimulation of PVN. 5. Vagotomy or sympathectomy both could increase the effect of PVN stimulation on GI-RI. These results indicate that the PVN participates in the development of GI-RI as a specific area in the CNS, exerting protective effects on the GI-RI. The NTS and vagus and sympathetic nerve may be involved in the regulative mechanism of PVN on GI-RI, but the PVN mechanism here is independent of the PVN-hypophyseal pathway.
Zhang
Jian-fu
JF
Department of Physiology, Xuzhou Medical College, 84 West Huaihai Road, 221002 Jiangsu, Xuzhou, People's Republic of China. zjf-xz@sina.com
Zhang
Yong-mei
YM
Yan
Chang-dong
CD
Zhou
Xiu-ping
XP
D000818:Animals; D004195:Disease Models, Animal; D004558:Electric Stimulation; D018698:Glutamic Acid / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000293:injuries / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000503:physiopathology*; D017552:Solitary Nucleus / Q000503:physiopathology / Q000601:surgery; D013564:Sympathetic Nervous System / Q000503:physiopathology* / Q000601:surgery; D014628:Vagotomy
D018698:Glutamic Acid