Genetics leads the way to the accomplices of presenilins.
Presenilins mediate the gamma-secretase cleavage of Notch transmembrane receptors as well as the transmembrane beta-amyloid precursor protein (betaAPP), but they are not thought to accomplish this alone. Recent genetic screens in C. elegans, presented in this issue of Developmental Cell, identify two genes that are essential to gamma-secretase activity and may interact with presenilins.
Goutte
Caroline
C
Department of Biology, Amherst College, Amherst, MA01002, USA.
D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D053764:Presenilin-1; D051880:Receptors, Notch
C405066:APH-1 protein, C elegans; D016564:Amyloid beta-Protein Precursor; D029742:Caenorhabditis elegans Proteins; D018398:Homeodomain Proteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D051880:Receptors, Notch