No enhancement of sensory and motor blockade by ketamine added to ropivacaine interscalene brachial plexus blockade.
BACKGROUND
Ketamine can enhance anesthetic and analgesic actions of a local anesthetic via a peripheral mechanism. The authors' goal was to determine whether or not ketamine added to ropivacaine in interscalene brachial plexus blockade prolongs postoperative analgesia. In addition, we wanted to determine the incidence of adverse-effects in patients undergoing hand surgery.


METHODS
Sixty adults scheduled for forearm or hand surgery under the interscalene brachial plexus block were prospectively randomized to receive one of the solutions of the study. Group P received 0.5% ropivacaine 30 ml, group K received 0.5% ropivacaine 30 ml with 30 mg ketamine, and group C received 0.5% ropivacaine with 30 mg ketamine i.v. Loss of shoulder abduction, elbow flexion, wrist flexion and loss of pinprick in the C4-7 sensory dermatomes were assessed at 1-min intervals. Adverse-effects were assessed every 5 min. The duration of the sensory and motor blocks was assessed after operation. Adverse-effects were also recorded.


RESULTS
The onset time of sensory or motor blockade and the duration of sensory or motor blockade were similar in all groups. Adverse-effects occurred in 44% of patients in group K and 94% of group C.


CONCLUSIONS
This study suggests that 30 mg ketamine added to ropivacaine in the brachial plexus block does not improve the onset or duration of sensory block, but it does cause a relatively high incidence of adverse-effects. These two findings do not encourage the use of ketamine with local anesthetics for brachial plexus blockade.
Lee
Il-Ok
IO
Department of Anesthesia, Woo-Kyung Kim, College of Medicine, Korea University, Korea University Guro Hospital, Seoul, South Korea. iloklee@hotmail.com
Kim
Woo-Kyung
WK
Kong
Myung-Hoon
MH
Lee
Mi-Kyung
MK
Kim
Nan-Sook
NS
Choi
Young-Seok
YS
Lim
Sang-Ho
SH
D000328:Adult; D000577:Amides / Q000008:administration & dosage* / Q000009:adverse effects; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects; D001917:Brachial Plexus; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009407:Nerve Block / Q000009:adverse effects; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D000077212:Ropivacaine; D013997:Time Factors
D000577:Amides; D000700:Analgesics; D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D007649:Ketamine; D000077212:Ropivacaine