High diastereoselectivity in intermolecular carbonyl ylide cycloaddition with aryl aldehyde using methyl diazo(trifluoromethyl)acetate.
[reaction: see text] Methyl diazo(trifluoromethyl)acetate undergoes Rh2(OAc)4 catalyzed reaction with aryl aldehyde to form 1,3-dioxolanes bearing a C-4 trifluoromethyl group diastereoselectively in excellent yield.
The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China. jiangb@pub.sioc.ac.cn
Biao
B
Jiang
Xiaobing
X
Zhang
Zhaohui
Z
Luo