[Expression and localization of Nogo-A mRNA in rat nerve tissue].
OBJECTIVE
To investigate the expression and localization of Nogo-A mRNA in brain, spinal cord, optic nerve, and sciatic nerve.


METHODS
Frozen sections of brain, spinal cord, optic nerve, and sciatic nerve of 8 rats were made. In situ hybridization was conducted and the sections were observed by light microscopy.


RESULTS
The expression of Nogo-A mRNA was positive in brain, spinal cord, and optic nerve, and negative in sciatic nerve.


CONCLUSIONS
The expression of Nogo-A mRNA is negative in brain, spinal cord, and optic nerve, which may be related to the poor axon regeneration in central nervous system.
Ye
Jian
J
Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Wang
Zhengguo
Z
Zhu
Peifang
P
D000818:Animals; D005260:Female; D015870:Gene Expression; D008297:Male; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism*; D009417:Nerve Tissue / Q000378:metabolism*; D000070798:Nogo Proteins; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603197:Rtn4 protein, rat