[Neurotrophic factors and autoantibodies to them as molecular predictors of cerebral dysfunctions].
A complex of clinical and immunochemical studies was made in patients with chronic brain ischemia and ischemic stroke and in neonatal infants with CNS dysfunctions and retarded intrauterine development. Enzyme immunoassay was used to measure the levels of brain proteins with trophic properties--S100b, the major protein myelin, lectins CSL, R1, and the levels of primary and antiidiotypic antibodies to these proteins in the biological fluids of the patients. The findings suggest that the study brain proteins and autoimmune processes against these factors are involved in the mechanisms of the pathogenesis of the diseases in question and they enable changes and variations in the levels of neurotropic factors and their autoantibodies to be considered as predictors of brain ischemia and perinatal cerebral lesions.
Sherstnev
V V
VV
Gruden'
M A
MA
Skvortsova
V I
VI
Tabolin
V A
VA
D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid / Q000502:physiology*; D001921:Brain / Q000276:immunology / Q000503:physiopathology; D002545:Brain Ischemia / Q000134:cerebrospinal fluid / Q000276:immunology*; D005317:Fetal Growth Retardation / Q000134:cerebrospinal fluid / Q000276:immunology*; D006801:Humans; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D011379:Prognosis
D001323:Autoantibodies; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins