Palladium(II)-mediated cascade carbonylative annulation of o-alkynyl-phenols on silyl linker-based macrobeads: a combinatorial synthesis of a 2,3-disubstituted benzo[b]furan library.
[reaction: see text] A palladium(II)-mediated cascade carbonylative annulation of o-alkynylphenols was achieved successfully on silyl linker-based macrobeads, which led to an efficient combinatorial synthesis of a 2,3-disubstituted benzo[b]furan library.
Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, SGM 604, Boston, Massachusetts 02115-5731, USA. r.fathi@vivoquest.com
Yun
Y
Liao
Michael
M
Reitman
Yan
Y
Zhang
Reza
R
Fathi
Zhen
Z
Yang
D000480:Alkynes / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis*; D001685:Biological Factors / Q000138:chemical synthesis; D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D010165:Palladium / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D012117:Resins, Synthetic
D000480:Alkynes; D001572:Benzofurans; D001685:Biological Factors; D010636:Phenols; D012117:Resins, Synthetic; D010165:Palladium; D002248:Carbon Monoxide; C105430:benzofuran