Convergent synthesis of an inner core GPI of sperm CD52.
An inner core of the GPI anchor of sperm CD52 antigens was synthesized by a highly convergent process using specially modified inositol, glucosamine and phospholipid as key building blocks. This paper also presents a new and efficient procedure to prepare 1,2,6-differentiated derivatives of inositol for GPI syntheses.
Department of Chemistry, Case Western Reserve University, Cleveland OH 44106, USA.
Jie
J
Xue
Zhongwu
Z
Guo
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000074301:CD52 Antigen; D002625:Chemistry, Organic / Q000379:methods; D005944:Glucosamine / Q000031:analogs & derivatives; D006023:Glycoproteins / Q000138:chemical synthesis*; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives; D008297:Male; D009947:Organotin Compounds / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry; D013094:Spermatozoa; D013237:Stereoisomerism
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D006023:Glycoproteins; D017261:Glycosylphosphatidylinositols; D009947:Organotin Compounds; D010743:Phospholipids; D007294:Inositol; D005944:Glucosamine