T-wave patterns associated with the hereditary long QT syndrome.
Mutations involving 6 different ion-channel genes have been identified in subjects with the hereditary Long QT Syndrome. These gene mutations result in structural and functional changes in ion-channel proteins with resultant alterations in potassium and sodium repolarization currents that affect the morphologic features of electrocardiographic repolarization. This review highlights the genotype-phenotype associations related to ventricular repolarization that have been reported in the LQTS literature, with particular focus on ECG T-wave patterns in LQT1, LQT2, and LQT3 genotypes.
Department of Medicine, Division of Cardiology, University of Rochester Medical Center, Rochester, New York, USA. heartajm@heart.rochester.edu
Arthur J
AJ
Moss
D000293:Adolescent; D000328:Adult; D004562:Electrocardiography / Q000379:methods*; D005838:Genotype; D006801:Humans; D007223:Infant; D008133:Long QT Syndrome / Q000235:genetics* / Q000503:physiopathology*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D015221:Potassium Channels / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology
D015221:Potassium Channels; D015222:Sodium Channels