Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.
Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.
Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009, India.
Somesh
S
Baranwal
Keya
K
Dey
T
T
Ramamurthy
G Balakrish
GB
Nair
Manikuntala
M
Kundu
D000890:Anti-Infective Agents / Q000378:metabolism* / Q000494:pharmacology*; D002771:Cholera / Q000382:microbiology*; D027081:DNA Gyrase / Q000235:genetics / Q000378:metabolism; D017931:DNA Primers; D027101:DNA Topoisomerase IV / Q000235:genetics / Q000378:metabolism; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D005798:Genes, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014734:Vibrio cholerae / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism
D000890:Anti-Infective Agents; D017931:DNA Primers; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase