Ena/Vasp: solving a cell motility paradox.
Modulating the concentration of the actin-binding protein Ena/Vasp within the lamellipodium of a migrating fibroblast results in marked changes in lamellipodium behaviour and actin network organization at the cell's leading edge. This can explain a cell motility paradox.
Cramer
Louise P
LP
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, UK. l.cramer@ucl.ac.uk
D001426:Bacterial Proteins / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D008089:Listeria monocytogenes; D008840:Microfilament Proteins / Q000502:physiology*; D010750:Phosphoproteins / Q000737:chemistry / Q000502:physiology*; D000098662:Vasodilator-Stimulated Phosphoprotein
D001426:Bacterial Proteins; D015815:Cell Adhesion Molecules; D008840:Microfilament Proteins; D010750:Phosphoproteins; D000098662:Vasodilator-Stimulated Phosphoprotein