EGF receptor activation by heterologous mechanisms.
A myriad of growth factor-dependent and -independent mechanisms for activating the EGF receptor and the related ErbB receptors underscore the importance of receptor inhibitors in the treatment of some solid tumors.
University of California, Davis, Cancer Center, Sacramento 95817, USA. klcarraway@ucdavis.edu
Kermit L
KL
Carraway
Colleen
C
Sweeney
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*; D055293:Receptors, Urokinase Plasminogen Activator; D015398:Signal Transduction / Q000502:physiology*; D015854:Up-Regulation
C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D066246:ErbB Receptors