[Involvement of the neuropeptide cholecystokinin in the mechanisms of regulation of emotions and craving].
The paper presents an idea on the organization and functions of the cholecystokinin (CCK) system. Particular emphasis is laid on the modulating influence of CCK on dopamine neuromediation in the mesolymbic structures of the brain, which are linked with the regulation of emotions and craving. Experimental and clinical studies have indicated that CCK and its preparations arrest the major manifestation of the withdrawal syndrome, including pathological craving for alcohol, and anxiety. In the post-withdrawal period, these drugs also effectively suppress alcohol craving. The designed new tetrapeptide, a CCK analogue, selectively inhibits anxiety in animals with this emotional disorder, which is followed by normalization of dopamine exchange and GABA-system functions. It is concluded that by interacting with the dopamine-system, CCK takes a direct part in the regulation of emotions and craving.
Anokhina
I P
IP
Proskuriakova
T V
TV
D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism* / Q000627:therapeutic use*; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D011949:Receptors, Cholecystokinin / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D011949:Receptors, Cholecystokinin; D000431:Ethanol; D002766:Cholecystokinin; D004298:Dopamine