[Effect of various antisecretory drugs on morphological changes in rat gastric mucosa in experimental stomach ulcers].
In experiments with white rats of Wistar linea there was reproduced the model of acetate gastric ulcer by Okabe. Since 7 day after ulcerogenous trauma the animals received one of the antisecretory drugs (sandostatine, famotidine, lansoprazole) for 14 days. There was studied the influence of these drugs on microcirculation and epithelium of gastric mucosa using morphometry. Using sandostatine and famotidine showed to decrease for sure the volumetric density of capillaries comparing with intact animals. Taking lansoprazole did not influenced on microcirculation state but markedly activated the regeneration of gastric epithelium.
Shcherbynina
M B
MB
Dniepropetrovsk State Medical Academy, Ministry of Public Health of Ukraine.
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D015738:Famotidine / Q000494:pharmacology / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000098:blood supply / Q000166:cytology / Q000187:drug effects*; D064747:Lansoprazole; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D015282:Octreotide / Q000494:pharmacology / Q000627:therapeutic use; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy*; D016896:Treatment Outcome
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D064747:Lansoprazole; D015738:Famotidine; D009853:Omeprazole; D015282:Octreotide