Odontogenic carcinoma: a functional genomic comparison with oral mucosal squamous cell carcinoma.
Intraosseous squamous cell carcinomas of the mandible arise de novo or secondary to a tumor or transformed cyst epithelium. Current diagnostic tests frequently fail to distinguish between these tumors, leading to confusing classification schemes. We report the functional genomic analysis of a mandibular odontogenic carcinoma. Malignant keratinocytes from the lesion were isolated using laser capture microdissection. Target sample generated from the total RNA of the LCM-procured cells was used to hybridize high-density oligonucleotide arrays. Functional genomic analysis of the odontogenic carcinoma database compared with four oral mucosal squamous cell carcinoma gene expression databases was performed. Preliminary results suggest a small subset of genes distinguish this odontogenic carcinoma from oral mucosal epidermoid carcinomas.
Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA.
Ilias
I
Alevizos
Bart
B
Blaeser
George
G
Gallagher
Hiroe
H
Ohyama
David T W
DT
Wong
Randy
R
Todd
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics*; D030541:Databases, Genetic; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D006801:Humans; D008339:Mandibular Neoplasms / Q000175:diagnosis / Q000235:genetics*; D009808:Odontogenic Tumors / Q000175:diagnosis / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics
D012334:RNA, Neoplasm