Metabolic treatment of pregnancy and postdelivery period in a patient with cobalamin A disease.
We report the successful treatment of a woman with Cobalamin A disease with hydroxycobalamin injections during pregnancy and delivery and 3 months after delivery. Urine and plasma methylmalonic acid levels served to adjust therapy before and after delivery. The mother had no untoward metabolic complications and gave birth to a normal baby.
Metabolic Service, Genetic Health Services, Murdoch Childrens Research Institute, Parkville, Australia.
Avihu
A
Boneh
Ronda F
RF
Greaves
Giuseppe
G
Garra
James J
JJ
Pitt
D003038:Cobamides / Q000172:deficiency*; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use*; D008661:Metabolism, Inborn Errors / Q000188:drug therapy*; D008764:Methylmalonic Acid / Q000652:urine*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014805:Vitamin B 12 / Q000378:metabolism
D003038:Cobamides; D008764:Methylmalonic Acid; C000913:cobamamide; D014805:Vitamin B 12; D006879:Hydroxocobalamin