Interventions for trichomoniasis in pregnancy.
BACKGROUND
Vaginitis due to Trichomonas vaginalis is one of the most common of sexually transmitted diseases. Trichomoniasis affects women during pregnancy as well but it is not clearly established whether it causes preterm birth and other pregnancy complications.


OBJECTIVE
The objective of this review was to assess the effects of various treatments for trichomoniasis during pregnancy.


METHODS
The Cochrane Pregnancy and Childbirth Group trials register was searched (March 2002).


METHODS
Randomized trials comparing antitrichomonas agents during pregnancy. Trials including symptomatic or asymptomatic women with trichomoniasis were eligible.


METHODS
Eligibility and trial quality was assessed by one reviewer.


RESULTS
Two trials with 842 pregnant women were included. In both trials around 90% of women were cleared of trichomonas in the vagina after treatment. In the US trial women with asymptomatic trichomoniasis between 16 to 23 weeks were treated with metronidazole on two occasions at least two weeks apart. The trial was stopped before reaching its target recruitment because metronidazole was not effective in reducing preterm birth and there was a likelihood of harm (relative risk: 1.8; 95% confidence interval: 1.2 to 2.7). The South African trial recruited women later in pregnancy and did not have the design and power to address adverse clinical outcomes.


CONCLUSIONS
Metronidazole, given as a single dose, is likely to provide parasitological cure for trichomoniasis, but it is not known whether this treatment will have any effect on pregnancy outcomes. The cure rate could probably be higher if more partners used the treatment.
UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and, Research Training in Human Reproduction (HRP), World Health Organization, Geneva 27, Switzerland. gulmezoglum@who.ch
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Gülmezoglu
D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
D000981:Antiprotozoal Agents; D008795:Metronidazole