On-line parameter identification of systemic circulation using the delta operator.
To develop effective medical care with the artificial heart, we propose a new method, on-line parameter identification of the systemic circulation using the delta operator which can calculate the time-varying and unmeasured hemodynamics of the internal human body from some measured data: aortic pressure and total flow in real time. This method consists of first, a dynamic physiological model which is configured with the physiological parameters Ca (aortic compliance) and Rp (total peripheral resistance); and second, a system identification method using the delta operator. In the computer simulation study, we could confirm the effectiveness to identify the physiological parameters. In animal experiments with a left ventricular assist system, the physiological parameters, Ca = 1.8 (ml/mm Hg) and Rp = 0.8 (mm Hg s/ml), could be identified on-line.
Institute of Systems of Engineering Mechanics, University of Tsukuba, Tsukuba, Japan. kosaka@golem.kz.tsukuba.ac.jp
Ryo
R
Kosaka
Yoshiyuki
Y
Sankai
Tomoaki
T
Jikuya
Takashi
T
Yamane
Tatsuo
T
Tsutsui
D000222:Adaptation, Physiological; D000465:Algorithms; D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D006354:Heart, Artificial; D006439:Hemodynamics; D008955:Models, Cardiovascular