T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study.
BACKGROUND
We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP).


METHODS
We recruited 802 subjects in a rural Japanese community who were aged >40 years and who gave written informed consent for monitoring of their ambulatory BP and genetic analysis (the Ohasama Study). As a polymorphism of AGT, T+31C, which is in complete linkage disequilibrium with M235T, was determined using the TaqMan polymerase chain reaction method.


RESULTS
The genotype distribution of AGT/T-+31C in the Ohasama Study was similar to that in another large Japanese population. Although there was no significant difference in 24-h and daytime ambulatory BP values, the nighttime BP was significantly lower in the subjects with TT, resulting in greater decline of nocturnal systolic (P = .090) and diastolic (P = .025) BP in subjects with TT.


CONCLUSIONS
AGT/T+31C is associated with the circadian BP variation but not with BP level in the Japanese general population.
Department of Clinical Pharmacology, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan.
Tohru
T
Fujiwara
Tomohiro
T
Katsuya
Mitsunobu
M
Matsubara
Tadayoshi
T
Mikami
Kazuhiko
K
Ishikawa
Masahiro
M
Kikuya
Takayoshi
T
Ohkubo
Atsushi
A
Hozawa
Mari
M
Michimata
Michiko
M
Suzuki
Hirohito
H
Metoki
Kei
K
Asayama
Tsutomu
T
Araki
Ichiro
I
Tsuji
Jitsuo
J
Higaki
Hiroshi
H
Satoh
Shigeru
S
Hisamichi
Toshio
T
Ogihara
Yutaka
Y
Imai
D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence
D000808:Angiotensinogen