Leu208Val and Ile181Leu variants of cytochrome P450 CYP2C9 are not related to the acenocoumarol dose requirement in a Spanish population.
José
J
Zarza
José
J
Hermida
Ramón
R
Montes
Ignacio
I
Alberca
Maria Luz
ML
López
Eduardo
E
Rocha
D000074:Acenocoumarol / Q000008:administration & dosage*; D019943:Amino Acid Substitution; D000925:Anticoagulants / Q000008:administration & dosage; D001189:Aryl Hydrocarbon Hydroxylases; D065729:Cytochrome P-450 CYP2C9; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D019934:International Normalized Ratio; D013030:Spain / Q000453:epidemiology; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000235:genetics*
D000925:Anticoagulants; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; D039181:Steroid 16-alpha-Hydroxylase; D000074:Acenocoumarol