Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.
Genomewide association studies may offer the best promise for genetic mapping of complex traits. Such studies in outbred populations require very densely spaced single-nucleotide polymorphisms. In recently founded population isolates, however, extensive linkage disequilibrium (LD) may make these studies feasible with currently available sets of short tandem repeat markers, spaced at intervals as large as a few centimorgans. We report the results of a genomewide association study of severe bipolar disorder (BP-I), using patients from the isolated population of the central valley of Costa Rica. We observed LD with BP-I on several chromosomes; the most striking results were in proximal 8p, a region that has previously shown linkage to schizophrenia. This region could be important for severe psychiatric disorders, rather than for a specific phenotype.
Ophoff
Roel A
RA
Neurogenetics Laboratory, University of California, San Francisco, CA, USA.
Escamilla
Michael A
MA
Service
Susan K
SK
Spesny
Mitzi
M
Meshi
Dar B
DB
Poon
Wingman
W
Molina
Julio
J
Fournier
Eduardo
E
Gallegos
Alvaro
A
Mathews
Carol
C
Neylan
Thomas
T
Batki
Steven L
SL
Roche
Erin
E
Ramirez
Margarita
M
Silva
Sandra
S
De Mille
Melissa C
MC
Dong
Penny
P
Leon
Pedro E
PE
Reus
Victor I
VI
Sandkuijl
Lodewijk A
LA
Freimer
Nelson B
NB
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D003364:Costa Rica; D005260:Female; D005819:Genetic Markers; D015894:Genome, Human; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D005819:Genetic Markers