Left ventricular end-diastolic volume from ejection fraction and stroke volume in pigs during IVC occlusion.
BACKGROUND
Real-time measurement of left ventricular end-diastolic volume (LVEDV), combined with left ventricular end-diastolic pressure (LVEDP), would allow continuous measurement of intraoperative diastolic function. In pursuit of this goal, we examined stroke volume divided by ejection fraction for calculation of LVEDV(sv/ef).


METHODS
Five anesthetized pigs underwent median sternotomy and pericardiotomy. A transit-time ultrasonic flow probe on the ascending aorta provided cardiac output. A micromanometer provided LV end-diastolic pressure. End-diastolic and end-systolic areas were measured from LV short-axis cross sections to obtain ejection fraction. LVEDV(sv/ef) was calculated during IVC occlusion. Steady-state LVEDV(echo) was determined using a three-plane echocardiography model. LVEDV(echo) was used to validate steady-state LVEDA in each experiment.


RESULTS
Correlation coefficients for linear and pressure-volume relation analyses ranged from 0.46 to 0.99. The two methods for measuring LVEDV generated compliance curves with an overall reliability coefficient of 0.84.


CONCLUSIONS
The LVEDV(sv/ef) method may facilitate real-time determination of LV compliance.
Department of Surgery, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
Cecily J
CJ
Gallup
Santos E
SE
Cabreriza
Joseph P
JP
Hart
Rowan
R
Walsh
Alan
A
Weinberg
Henry M
HM
Spotnitz
D000818:Animals; D001011:Aorta / Q000502:physiology; D003187:Compliance; D003935:Diagnostic Techniques, Cardiovascular / Q000592:standards; D008026:Ligation; D016014:Linear Models; D015203:Reproducibility of Results; D013318:Stroke Volume; D013552:Swine; D014682:Vena Cava, Inferior / Q000503:physiopathology*