[Massive hemolysis following allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility].
We observed massive hemolysis after allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility (the donor was group O and the recipient group A). The patient was a 21-year-old man diagnosed as having Philadelphia chromosome-positive chronic myelogenous leukemia. On day 7 post-transplant, there was abrupt onset of massive hemolysis necessitating supportive treatment with transfusions. During the allogeneic peripheral blood stem cell transplantation the patient had received 2 x 10(8) CD3 positive cells/kg and 7.8 x 10(7) CD19 positive cells/kg donor lymphocytes with stem cells. The present case shows that in allogeneic peripheral blood stem cell transplantation with ABO incompatibility, severe hemolysis occurs early after transplantation presumably due to the transfusion of a large number of lymphocytes.
Ishiyama
Midori
M
Department of Hematology, Tokyo Women's Medical University.
Iwabe
Koji
K
Hida
Mayumi
M
Okamura
Takamitu
T
Yoshinaga
Kentaro
K
Hidai
Hiroko
H
Kobayashi
Shoko
S
Sameshima
Yuich
Y
Mori
Naoki
N
Teramura
Masanao
M
Masuda
Michihiko
M
Motoji
Toshiko
T
Mizoguchi
Hideaki
H
D000017:ABO Blood-Group System; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006461:Hemolysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008297:Male
D000017:ABO Blood-Group System