[4 + 2] cycloaromatization of 4-bis(methylthio)-3-buten-2-one with active methylene ketones: a simple and facile phenol annulation.
A new method for beta-phenol annulation involving base-induced [4C + 2C] cycloaromatization of readily available 4-bis(methylthio)-3-buten-2-one with a variety of cyclic and acyclic active methylene ketones has been reported. Appropriate choice of ketones allows synthesis of diverse frameworks such as dihydroindan, tetrahydronaphthalenes, their higher homologues, dihydro/octahydrophenanthrenes, anthracene, and heteroannulated analogue in high yields with regiocontrol of phenolic functionality.
Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, U. P. India.
Okram
O
Barun
Sukumar
S
Nandi
Kausik
K
Panda
Hiriyakkanavar
H
Ila
Hiriyakkanavar
H
Junjappa