[Synthesis of biomimetic analogs of neomycin B].
Neomycin B has been found to block the binding of HIV-1 Rev protein to its viral RNA recognition site, thereby inhibiting the production of the virus. This paper describes the synthesis of analogues of neomycin B, which are potential anti-HIV compounds designed as inhibitors of Rev/RRE binding.
Nishizono
Naozumi
N
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan. nishizon@hoku-iryo-u.ac.jp
D019380:Anti-HIV Agents; D003864:Depression, Chemical; D005601:Framycetin / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000494:pharmacology; D015694:Gene Products, rev / Q000378:metabolism; D015497:HIV-1 / Q000254:growth & development; D011485:Protein Binding / Q000187:drug effects; D012367:RNA, Viral / Q000378:metabolism; D054321:rev Gene Products, Human Immunodeficiency Virus
D019380:Anti-HIV Agents; D015694:Gene Products, rev; D012367:RNA, Viral; D054321:rev Gene Products, Human Immunodeficiency Virus; D005601:Framycetin