Papular-purpuric gloves-and-socks syndrome with bloody bullae.
Papular-purpuric gloves-and-socks syndrome (PPGSS) is a disease characterized by itchy, painful acral erythema with edema, confluent papules, and purpura in a gloves-and-socks distribution and is associated with fever and mucosal lesions. Parvovirus B19 and other viral infections have been proven to be causative agents of this syndrome. Its histological findings have been the non-specific ones of interface dermatitis. Here, we report a case of PPGSS in a 44-year-old man that we believe to be the first such case in Japan. He developed, within one day, a painful edematous eruption with confluent papules and purpura on his hands and feet accompanied by high fever. A unique clinical manifestation in this case was multiple bloody bullae on the toes, which have not been previously described. Serological tests were negative for parvovirus B19, cytomegalovirus, and measles virus.
Higashi
Natsuko
N
Department of Dermatology, Osaka City University, Medical School, Japan.
Fukai
Kazuyoshi
K
Tsuruta
Daisuke
D
Nagao
Jun
J
Ohira
Hidehiro
H
Ishii
Masamitsu
M
D000328:Adult; D001768:Blister / Q000175:diagnosis*; D003872:Dermatitis / Q000175:diagnosis*; D005533:Foot Dermatoses / Q000175:diagnosis*; D006229:Hand Dermatoses / Q000175:diagnosis*; D006801:Humans; D008297:Male; D016732:Parvovirus B19, Human / Q000302:isolation & purification; D011693:Purpura / Q000175:diagnosis*; D013577:Syndrome