Morphological evidence that CA1 hippocampal afferents monosynaptically innervate PV-containing neurons and NADPH-diaphorase reactive cells in the medial prefrontal cortex (Areas 25/32) of the rat.
Immunocytochemical and ultrastructural evidence is presented indicating that direct inputs from the hippocampal CA1 field to prelimbic (area 32) and infralimbic (area 25) cortices in the rat, innervate not only 'spiny' (presumed pyramidal) neurons but also monosynaptically contact NADPH-diaphorase reactive cells and parvalbumin-containing local circuit neurons-the latter cell type is shown to be GABA immunoreactive. Similar evidence of direct CA1 input to local circuit neurons containing either calbindin or calretinin was not found.
University Department of Pharmacology, OX1 3QT, Oxford, UK. paul.gabbott@psy.ox.ac.uk
Paul
P
Gabbott
Anthony
A
Headlam
Sarah
S
Busby
D000344:Afferent Pathways / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D000818:Animals; D064032:Calbindin 2; D064026:Calbindins; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D007150:Immunohistochemistry; D008032:Limbic System / Q000378:metabolism / Q000502:physiology; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009475:Neurons, Afferent / Q000502:physiology* / Q000648:ultrastructure; D010320:Parvalbumins / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
C576512:Calb2 protein, rat; D064032:Calbindin 2; D064026:Calbindins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D005680:gamma-Aminobutyric Acid; D009252:NADPH Dehydrogenase