Complete adrenocorticotropin deficiency after radiation therapy for brain tumor with a normal growth hormone reserve.
A 34-year-old man with neurofibromatosis type 1, who had received radiation therapy after the excision of a brain tumor 5 years earlier, was admitted to our hospital with vomiting and weight loss. Cortisol and adrenocorticotropin (ACTH) were undetectable before and after administration of 100 microg corticotropin releasing hormone. The level of growth hormone without stimulation was 24.7 ng/ml. We diagnosed him to have complete ACTH deficiency attributable to radiation therapy. This is the first known case of a patient with complete ACTH deficiency after radiation therapy and a growth hormone reserve that remained normal.
Department of Internal Medicine, Osaka City General Hospital, Miyakojima.
Haruna
H
Sakai
Katsunobu
K
Yoshioka
Keiko
K
Yamagami
Tetsuya
T
Yamakita
Masayuki
M
Hosoi
Tomofusa
T
Ishii
Toshihiko
T
Sato
Shiro
S
Tanaka
Yoshiyasu
Y
Iwai
Satoru
S
Fujii
D000309:Adrenal Insufficiency / Q000209:etiology; D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000328:Adult; D001254:Astrocytoma / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D016371:Cranial Irradiation / Q000009:adverse effects*; D003940:Diagnostic Techniques, Endocrine; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000172:deficiency; D008279:Magnetic Resonance Imaging; D008297:Male; D010913:Pituitary-Adrenal System / Q000528:radiation effects; D011832:Radiation Injuries / Q000209:etiology* / Q000378:metabolism; D016896:Treatment Outcome
D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone