Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid.
A role for chemokines as mediators of Th1 cell recruitment to the central nervous system (CNS) is probable in MS. Therefore we studied expression of Th1-related CCR5 and CXCR3 chemokine receptors in patients with MS and controls. Patients with untreated MS had elevated percentages of CCR5 and CXCR3 expressing T cells vs. healthy controls (HC) in blood, and vs. other non-inflammatory neurological diseases (OND) patients in CSF. Such elevation was not found in MS patients examined during ongoing treatment with IFN-beta. Patients with optic neuritis (ON), a common first manifestation of MS, had elevated percentages of CXCR3 expressing T cells in blood compared with HC, and of CCR5 expressing T cells in CSF compared with OND patients. High chemokine receptor expression may be one prerequisite for Th1 cells to migrate to the CNS. Inhibition of chemokine receptor expression may constitute a potentially important therapeutic effect of IFN-beta.
Department of Neurology, Karolinska Institutet, Huddinge University Hospital, 14186 Stockholm, Sweden.
Natalia
N
Teleshova
Mikhail
M
Pashenkov
Yu-Min
YM
Huang
Mats
M
Söderström
Pia
P
Kivisäkk
Vasilios
V
Kostulas
Mats
M
Haglund
Hans
H
Link
D000328:Adult; D002452:Cell Count; D018946:Chemokine CCL5 / Q000097:blood / Q000134:cerebrospinal fluid; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000097:blood / Q000134:cerebrospinal fluid; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000276:immunology; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D009902:Optic Neuritis / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000276:immunology; D019713:Receptors, CCR5 / Q000097:blood* / Q000276:immunology; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000097:blood* / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology*
C515187:CXCR3 protein, human; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D019713:Receptors, CCR5; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine; D016899:Interferon-beta