Biomonitoring of tobacco smoke carcinogenicity by dosimetry of DNA adducts and genotyping and phenotyping of biotransformational enzymes: a review on polycyclic aromatic hydrocarbons.
In this review article, we summarize the data on tobacco smoke carcinogenicity in relation to DNA adduct dosimetry and genotyping and phenotyping of biotransformational enzymes. A major class of carcinogens, polycyclic aromatic hydrocarbons, present in substantial quantities in tobacco smoke, is discussed. The historical background and an overview of the metabolic pathways are given. The epidemiological and biological data in particular on dosimetry of the representative DNA adducts and genotyping and phenotyping of the respective activating and detoxifying enzymes are presented. The salient findings are highlighted, the uncertainties are underlined and, finally, recommendations for future research are made.
Department of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010-3000, USA. ania@coh.org
A
A
Besaratinia
A
A
Besarati Nia
J C S
JC
Kleinjans
F J
FJ
Van Schooten
D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D018736:DNA Adducts / Q000032:analysis* / Q000096:biosynthesis; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D010641:Phenotype; D010761:Phosphorus Radioisotopes; D011084:Polycyclic Aromatic Hydrocarbons / Q000493:pharmacokinetics / Q000633:toxicity*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012906:Smoke / Q000032:analysis; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
D002273:Carcinogens; D018736:DNA Adducts; D010761:Phosphorus Radioisotopes; D011084:Polycyclic Aromatic Hydrocarbons; D012906:Smoke; D014028:Tobacco Smoke Pollution; D003577:Cytochrome P-450 Enzyme System