Host-pathogen interactions and the pathogenesis of murine Lyme disease.
Lyme disease results from persistent infection with the spirochete Borrelia burgdorferi. A combination of bacterial factors and host factors contributes to the development of inflammatory disease. Studies from the past year have provided insight into both sides of this host-pathogen interplay. We now have a better appreciation of the bacterial genes and products that are involved in pathology and the components of the host response that participate in disease development.
Division of Cell Biology and Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132-2501, USA. janis.weis@path.utah.edu
Janis J
JJ
Weis
D000818:Animals; D001170:Arthritis, Infectious / Q000276:immunology* / Q000382:microbiology; D025065:Borrelia burgdorferi / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D004195:Disease Models, Animal; D007113:Immunity, Innate; D008193:Lyme Disease / Q000276:immunology* / Q000382:microbiology; D051379:Mice