Feed thickener for newborn infants with gastro-oesophageal reflux.
BACKGROUND
Gastro-oesophageal reflux (GOR) is common in newborn infants. A common first line management is the use of feed thickeners.


OBJECTIVE
In newborn infants with GOR, to evaluate the use of feed thickeners in reducing signs and symptoms of GOR, acid episodes on pH monitoring and histological evidence of oesophagitis.


METHODS
We searched MEDLINE from 1966 to December 2001, the Cochrane Controlled Trials Register, The Cochrane Library, Issue 1, 2002. CINAHL from 1982 to December 2001, and conference and symposia proceedings published in Pediatric Research 1990 to 1994. We also searched conference proceedings for the European Society for Paediatric Gastroenterology and Nutrition (ESPGAN) and the North American Society for Pediatric Gastroenterology and Nutrition (NASPGAN) from 1994 to December 2001. We did not restrict the searches to the English language.


METHODS
All randomised controlled trials that examine the effects of thickening formulas on treating gastro-oesophageal reflux in neonates. The eligible studies were to compare thickened feeds to no intervention (unthickened feeds).


METHODS
Two independent reviewers identified potential studies from the literature search. Quality was independently assessed by two independent reviewers.


RESULTS
No studies fulfilled the requirements for inclusion in the systematic review.


CONCLUSIONS
There is no evidence from randomised controlled trials to support or refute the efficacy of feed thickeners in newborn infants with GOR. Given the absence of evidence, we cannot recommend using thickening agents for management of GOR in newborn infants.
Gastroenterology, Princess Margaret Hospital, Perth, WA, Australia, Roberts Road, GPO D184, Perth, Western Australia, Australia. rae_chi@hotmail.com
R C
RC
Huang
D A
DA
Forbes
M W
MW
Davies
D005503:Food Additives / Q000627:therapeutic use*; D005764:Gastroesophageal Reflux / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn
D005503:Food Additives