Detection and monitoring of methotrexate-associated lung injury using serum markers KL-6 and SP-D in rheumatoid arthritis.
The applicability of monitoring concentrations of serum KL-6 and serum surfactant protein-D (SP-D) in the detection of methotrexate-associated lung injury (MTX pneumonitis) in patients with rheumatoid arthritis (RA) was investigated. The concentrations of these markers, sequentially measured in two patients with RA complicated with MTX pneumonitis, were increased in accordance with the severity of MTX pneumonitis. Conversely, the concentrations of these markers were decreased with the improvement of MTX pneumonitis, suggesting that the monitoring of these markers could be applicable not only for detecting the onset of MTX pneumonitis, but also for detecting the therapeutic response of MTX pneumonitis.
Department of Internal Medicine, Fukushima Red Cross Hospital.
Masayuki
M
Miyata
Fumitaka
F
Sakuma
Etsuko
E
Fukaya
Hiroko
H
Kobayashi
Takeshi
T
Rai
Hironobu
H
Saito
Reiji
R
Kasukawa
Shuzo
S
Suzuki
D000368:Aged; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000941:Antigens; D000951:Antigens, Neoplasm; D018501:Antirheumatic Agents; D015415:Biomarkers; D005938:Glucocorticoids; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D; D008775:Methylprednisolone; D008727:Methotrexate