Massive gabapentin and presumptive quetiapine overdose.
Previous reports of gabapentin overdose have described mild symptoms of somnolence, ataxia and slurred speech. Quetiapine has produced a false positive for cyclic antidepressants on immunoassay drugscreens. Quetiapine overdose is associated with coma, QTc prolongation and hypotension. We report a case of massive gabapentin and presumptive quetiapine overdose with the highest recorded serum gabapentin concentration (104.5 u/ml) associated with coma, respiratory depression requiring mechanical ventilation, and hypotension.
Spiller
Henry A
HA
Kentucky Regional Poison Center, Louisville, USA.
Dunaway
Michael D
MD
Cutino
Letizia
L
D000085:Acetates / Q000097:blood* / Q000506:poisoning*; D000588:Amines; D014151:Anti-Anxiety Agents / Q000097:blood* / Q000506:poisoning*; D014150:Antipsychotic Agents / Q000097:blood* / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced; D003509:Cyclohexanecarboxylic Acids; D003987:Dibenzothiazepines / Q000097:blood* / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D000077206:Gabapentin; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008875:Middle Aged; D000069348:Quetiapine Fumarate; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000139:chemically induced; D013406:Suicide, Attempted; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D003509:Cyclohexanecarboxylic Acids; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin