Polymer surfaces derivatized with poly(vinyl-N-hexylpyridinium) kill airborne and waterborne bacteria.
A facile methodology has been developed for covalently derivatizing the surfaces of common materials with a designed antibacterial polycation, poly(vinyl-N-pyridinium bromide), wherein the first, key step involves surface coating with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner become bactericidal-they kill up to 99% of deposited, from either an aerosol or an aqueous suspension, Gram-positive and Gram-negative bacteria on contact.
Tiller
Joerg C
JC
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Lee
Sang Beom
SB
Lewis
Kim
K
Klibanov
Alexander M
AM
D000391:Air Microbiology; D001422:Bacterial Adhesion; D020099:Coated Materials, Biocompatible; D004202:Disinfectants / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008956:Models, Chemical; D036103:Nanotechnology; D011108:Polymers / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013499:Surface Properties; D014871:Water Microbiology
D020099:Coated Materials, Biocompatible; D004202:Disinfectants; D011108:Polymers; D011726:Pyridinium Compounds; C470352:poly(vinyl-N-pyridinium bromide)