Kidney functions in newly diagnosed type 2 diabetic subjects: role of glycemic control.
BACKGROUND
The increased urinary albumin excretion (UAE) found at the diagnosis in type 2 diabetes may at least be functional and, thus reversible, as in type 1 diabetes. Furthermore, a positive correlation has been found between the glycemic control and UAE in type 2 diabetic subjects.


METHODS
The impact of glycemic control after achieving three months of continuous normo-glycemia was studied in 26 (including 16 males and 10 females) newly diagnosed type 2 diabetic patients to assess renal size/volumes, various renal functions and UAE.


RESULTS
A significant reduction was seen in glomerular filtration rate (GFR), UAE and fractional albumin clearance after achieving near normoglycemia (p < 0.01). A decrease in the kidney size/volume, though statistically insignificant, was also observed. Besides a decline in GFR of 4.8% was also noted after three months of stable normoglycemia. UAE normalized in six of these subjects. A statistically significant correlation was also found between the changes in mean fasting plasma glucose and the decline in UAE (r=0.56 and p < 0.01).


CONCLUSIONS
The study emphasizes the necessity to correct the apparently reversible increase in microabuminuria that accompanies hyperglycemia prior to patients recruitment for intervention therapy.
Department of Medicine, JN Medical College, Aligarh.
J
J
Ahmad
M
M
Singh
S
S
Kumar
D000419:Albuminuria / Q000628:therapy; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006943:Hyperglycemia / Q000628:therapy*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose