Adhesion of viridans group streptococci to sialic acid-, galactose- and N-acetylgalactosamine-containing receptors.
The binding of 10 viridans group streptococci to sialic acid-, galactose (Gal)- and N-acetylgalactosamine (GalNAc)-containing receptors was defined by analysis of the interactions between these bacteria and structurally defined glycoconjugates, host cells and other streptococci. All interactions with sialic acid-containing receptors were Ca(2+)-independent as they were not affected by ethyleneglycoltetraacetic acid (EGTA), whereas all interactions with Gal- and GalNAc-containing receptors were Ca(2+)-dependent. Recognition of sialic acid-, Gal- and GalNAc-containing receptors varied widely among the strains examined, in a manner consistent with the association of each of the three lectin-like activities with a different bacterial cell surface component.
Takahashi
Y
Y
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Ruhl
S
S
Yoon
J-W
JW
Sandberg
A L
AL
Cisar
J O
JO
D000116:Acetylgalactosamine / Q000378:metabolism; D001422:Bacterial Adhesion / Q000502:physiology*; D018441:Biofilms; D002118:Calcium / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D006001:Glycoconjugates / Q000378:metabolism*; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D034363:Viridans Streptococci / Q000502:physiology*
D006001:Glycoconjugates; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C047105:bacterial adhesin receptor; D019158:N-Acetylneuraminic Acid; D000116:Acetylgalactosamine; D002118:Calcium; D005690:Galactose