C4 deficiency state in antiphospholipid antibody-related recurrent preeclampsia evolving into systemic lupus erythematosus.
The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations, such as complement genetic deficiencies, in women with primary antiphospholipid syndrome who develop systemic lupus erythematosus is also discussed.
Queiro
Rubén
R
Hospital Central de Asturias, Oviedo-Asturias, Spain. ruquei@mixmail.com
Weruaga
Ana
A
Riestra
José L
JL
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology; D003181:Complement C4 / Q000172:deficiency* / Q000235:genetics; D004359:Drug Therapy, Combination; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D008750:Methyldopa / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000150:complications* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D003181:Complement C4; D008750:Methyldopa; D011239:Prednisolone