[Effect of irbesartan, an antagonist of AT-1 receptors for angiotensin II, on L-arginine metabolism in arterial hypertension].
Effects of an antagonist of AT-1 receptors for angiotensin-II (Ang-II) irbezantane on the NO-synthase and arginase ways of the metabolism of L-arginine were studied in plasma and erythrocytes of the patients with arterial hypertension. The intensity of the non-oxidative arginase way of L-arginine metabolism in plasma and erythrocytes has been shown to be inhanced at hypertension versus the normotensive patients, while the activity of the alternative oxidative NO-synthase way was reduced. Inhibiting AT-1 receptors for Ang-II with high-affinity antagonist irbezantane normalized the ratio between two alternative ways of L-arginine metabolism through inhibiting the arginase way and reciprocal activating the NO-synthase way both in human plasma and erythrocytes.
A.V. Palladin Institute of Biochemistry, National Academy of Science of Ukraine.
A V
AV
Kotsiuruba
Ie P
IeP
Svishchenko
O M
OM
Bukhanevich
H V
HV
Kosiakova
A H
AH
Berdyshev
V V
VV
Radchenko
L A
LA
Mishchenko
N M
NM
Hula
D000804:Angiotensin II / Q000378:metabolism; D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001119:Arginase / Q000097:blood; D001120:Arginine / Q000097:blood*; D001713:Biphenyl Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D001782:Blood Donors; D001794:Blood Pressure; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D000077405:Irbesartan; D019001:Nitric Oxide Synthase / Q000097:blood; D011945:Receptors, Angiotensin / Q000378:metabolism; D013777:Tetrazoles / Q000494:pharmacology / Q000627:therapeutic use*
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D011945:Receptors, Angiotensin; D013777:Tetrazoles; D000804:Angiotensin II; D001120:Arginine; D019001:Nitric Oxide Synthase; D001119:Arginase; D000077405:Irbesartan