Intractable epilepsy and mild brain injury: incidence, pathology and surgical outcome.
OBJECTIVE
To study the role of mild brain injury in intractable epilepsy.


METHODS
The medical charts of 86 patients who underwent surgery for intractable epilepsy were reviewed in regard to the history of mild brain injury, pathology and surgical outcome.


RESULTS
Nine of 86 patients had a previous history of mild brain injury (10.4%) compared to 2.5% of 80 age and sex matched controls. Six of nine patients had non-neoplastic and three had neoplastic lesions. Post-surgical outcome was excellent in eight of nine patients (Engel class IA).


CONCLUSIONS
The incidence of mild brain injury was 4-times higher in patients with intractable epilepsy compared to asymptomatic controls. The pathology was variable but in four of nine patients it was compatible with the described pathology in traumatic brain injury. Both groups, with or without brain injury, had good surgical outcome (88% versus 70%).
Department of Neurology and Neurosurgery Service, Walter Reed Army Medical Center, Washington, DC, USA. bjabbari@usuhs.mil
Bahman
B
Jabbari
Olga
O
Prokhorenko
Kaveh
K
Khajavi
Hernando
H
Mena
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001930:Brain Injuries / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D004351:Drug Resistance; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D012189:Retrospective Studies; D016896:Treatment Outcome