Cooperation between mglu receptors: a depressing mechanism?
Recent findings from the perirhinal cortex have shed new light on the ways in which metabotropic glutamate receptors could be involved in synaptic plasticity, and in particular in long-term depression (LTD) of synaptic transmission. Importantly, these findings have also led to a greater understanding of mechanisms that could regulate mglu-receptor signalling and the ways in which mglu receptors interact with one another.
Department of Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.
Kwangwook
K
Cho
Zafar I
ZI
Bashir
D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D020534:Parahippocampal Gyrus / Q000378:metabolism* / Q000648:ultrastructure; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D000242:Cyclic AMP