Experimental neuroschistosomiasis: inadequacy of the murine model.
Neuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature. Severe, recent and late Schistosoma mansoni infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.
Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Fiocruz, Salvador, BA, 40295-001, Brasil.
Luciana M
LM
Silva
Carla Neves de
CN
Oliveira
Zilton A
ZA
Andrade
D000818:Animals; D001921:Brain / Q000469:parasitology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D020818:Neuroschistosomiasis; D010270:Parasite Egg Count