Study of flavonoids/beta-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation.
Flavonoids are natural substances with a lot of biological activities, including the antioxidant one. Their use in pharmaceutical field is, however, limited by their aqueous insolubility. As the formation of the inclusion complexes can improve their solubility in water, the flavonoids hesperetin, hesperidin, naringenin and naringin have been complexed with beta-cyclodextrin (beta-CD) by the coprecipitation method and studied in solution and in solid state by NMR, FT-IR, differential scanning calorimetry and X-ray techniques. The effects of complexation on the chemical shifts of the internal and external protons of beta-CD in the presence of each flavonoid were observed.
Ficarra
R
R
Facoltà di Farmacia, Università di Catanzaro, compl. Barbieri, 88021 Roccelletta di Borgia, Catanzaro, Italy.
Tommasini
S
S
Raneri
D
D
Calabrò
M L
ML
Di Bella
M R
MR
Rustichelli
C
C
Gamberini
M C
MC
Ficarra
P
P
D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000032:analysis* / Q000737:chemistry; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry; D005419:Flavonoids / Q000032:analysis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004337:Drug Carriers; D005419:Flavonoids; D012996:Solutions; D047392:beta-Cyclodextrins; C031215:betadex