Enantioseparation of glutethimide and its 5-OH-metabolite in capillary electrophoresis and study of selector-selectand interactions using one-dimensional rotating frame nuclear Overhauser and exchange spectroscopy.
Enantioseparation of glutethimide (GT) and its 5-hydroxy metabolite (5-OH-GT) has been studied with several charged cyclodextrin (CD) derivatives. The emphasis was made on the enantiomer migration order of GT and simultaneous enantioseparation of GT and 5-OH-GT. The possible structural differences of GT complexes with three different single isomer charged CD derivatives were studied using one-dimensional rotating frame nuclear Overhauser and exchange spectroscopy (1-D ROESY).
Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany. chankve@uni-muenster.de
Bezhan
B
Chankvetadze
Naira
N
Burjanadze
Klaus
K
Bergander
Gottfried
G
Blaschke
D003505:Cyclodextrins; D005984:Glutethimide / Q000031:analogs & derivatives* / Q000032:analysis*; D007202:Indicators and Reagents; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D007202:Indicators and Reagents; D012996:Solutions; D047392:beta-Cyclodextrins; C447200:heptakis(2,3-diacetyl-6-sulfo)-cyclodextrin; C447199:heptakis(2-O-methyl-3,6-di-O-sulfo)-beta-cyclodextrin; C015936:4-hydroxyglutethimide; D005984:Glutethimide