Autoimmune progesterone dermatitis manifested as erythema annulare centrifugum: Confirmation of progesterone sensitivity by in vitro interferon-gamma release.
Autoimmune progesterone dermatitis was manifested as deep-type erythema annulare centrifugum. Sensitivity to progesterone was studied in vivo by means of intradermal and patch tests, which revealed immediate-type and delayed-type hypersensitivity, respectively. Sensitivity to progesterone was further confirmed in vitro by results of an interferon-gamma release test, which imply a possible role for T(H)1-type cytokines in autoimmune progesterone dermatitis.
Department of Dermatology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.
Sima
S
Halevy
Arnon D
AD
Cohen
Eitan
E
Lunenfeld
Nili
N
Grossman
D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications* / Q000503:physiopathology; D002478:Cells, Cultured; D003875:Drug Eruptions / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D004890:Erythema / Q000209:etiology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007428:Intradermal Tests; D008214:Lymphocytes / Q000276:immunology; D008598:Menstruation; D011374:Progesterone / Q000009:adverse effects*
D011374:Progesterone; D007371:Interferon-gamma