A simple and versatile method for the synthesis of acetals from aldehydes and ketones using bismuth triflate.
Acetals are obtained in good yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of 0.1 mol % Bi(OTf)3.4H2O. A simple procedure for the formation of acetals of diaryl ketones has also been developed. The conversion of carbonyl compounds to the corresponding 1,3-dioxolane using ethylene glycol is also catalyzed by Bi(OTf)3.4H2O (1 mol %). Two methods, both of which avoid the use of benzene, have been developed.
Leonard
Nicholas M
NM
Department of Chemistry, Illinois Wesleyan University, Bloomington, Illinois 61701, USA.
Oswald
Matthew C
MC
Freiberg
Derek A
DA
Nattier
Bryce A
BA
Smith
Russell C
RC
Mohan
Ram S
RS