Periosteal donor site regeneration in rats.
Periosteal regeneration was investigated in two periosteal donor sites of the femur. The periosteum was taken from the femur epiphyses and diaphyses of 32 rats. The animals were sacrificed 1, 2, 3, 4 and 8 weeks after periosteal stripping. Intense cell proliferation occurred in the first week. After two weeks, a thick tissue layer formed by osteoblasts and undifferentiated cells was seen at the two donor sites. Eight weeks after, the periosteum had the same aspect as that from the right femur, which was used as control. Histomorphometric analysis showed that periosteal regeneration was significantly different between epiphyses and diaphyses. Periosteal regeneration at donor site located in epiphyses presented greater proliferation and better osteogenic activity than that observed in diaphyses.
Institute of Biology, Department of Anatomy, State University of Campinas-UNICAMP, São Paulo, Brazil.
R
R
da Vieira Silva
J A
JA
Camilli
D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation; D002455:Cell Division; D018483:Diaphyses / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D004838:Epiphyses / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D005269:Femur; D008297:Male; D010012:Osteogenesis; D010521:Periosteum / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors