[Role of positron emission tomography in detecting recurrent epithelial ovarian carcinoma].
OBJECTIVE
To investigate the efficiency of positron emission tomography (PET) with (fluorine-18)-2-deoxyglucose ((18)FDG) for detecting recurrent epithelial ovarian carcinoma.


METHODS
Fifteen (18)FDG-PET scanning were performed on 13 patients, who was clinically free of disease after optimal cytoreductive surgery and sufficient chemotherapy, with suspicion of recurrence. Ten second-look or re-debulking operation were given after PET scanning.


RESULTS
In all 8 cases with and 1 without elevated serum CA(125), PET demonstrated sites of increased (18)FDG uptake, which correlated well with surgical-pathologic findings (100%). Computed tomography scan and B  ultrasonography each detected 1 recurrence. One of the 6 patients with negative PET scan results underwent a second-look operation, which found no malignancy. The other 5 were closely followed up for 11 to 13 months. No sign of recurrence was noticed within 8 months.   One patient received her second PET scanning after the serum CA(125) began to elevate in the 9th month. Recurrent tumor was found by the second PET scan and confirmed by the operation after that.


CONCLUSIONS
PET is accurate in detecting the recurrent epithelial ovarian carcinoma. As a non-invasive method, PET might be a fairly effective tool for monitoring and locating the recurrence of ovarian carcinoma.
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Xun
X
Zhu
Keng
K
Shen
Jinghe
J
Lang
Ming
M
Wu
Huifang
H
Huang
Lingya
L
Pan
D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D018394:CA-125 Antigen; D019788:Fluorodeoxyglucose F18