A role for peroxisomes in photomorphogenesis and development of Arabidopsis.
The nuclear protein DET1 is a central repressor of photomorphogenesis in plants. We have identified the molecular lesion in ted3, a mutation that dominantly suppresses the phenotypes of det1-1. TED3 encodes a peroxisomal protein (AtPex2p) essential for Arabidopsis growth. Developmental defects and the abnormal expression of many genes in det1 are rescued by ted3. ted3 also partially suppresses another pleiotropic de-etiolated mutant cop1. Thus, peroxisomes, whose functions are still largely unexplored, play a key role in a photomorphogenetic pathway negatively regulated by the DET1 and COP proteins.
Hu
Jianping
J
Plant Biology Laboratory, Howard Hughes Medical Institute, Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Aguirre
Maria
M
Peto
Charles
C
Alonso
Jose
J
Ecker
Joseph
J
Chory
Joanne
J
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D029681:Arabidopsis Proteins / Q000032:analysis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D003433:Crosses, Genetic; D003624:Darkness; D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D016153:Genes, Suppressor; D018546:Hypocotyl / Q000254:growth & development; D007211:Indoles / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008027:Light; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D000074401:Peroxins; D020675:Peroxisomes / Q000737:chemistry / Q000502:physiology*; D018517:Plant Roots / Q000254:growth & development; D030821:Plants, Genetically Modified; D011993:Recombinant Fusion Proteins; D014170:Transformation, Genetic; D044767:Ubiquitin-Protein Ligases
D029681:Arabidopsis Proteins; D002352:Carrier Proteins; C088435:DET1 protein, Arabidopsis; D007211:Indoles; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D000074401:Peroxins; D011993:Recombinant Fusion Proteins; C462525:TED3 protein, Arabidopsis; C014612:indolebutyric acid; C471983:AT2G32950 protein, Arabidopsis; D044767:Ubiquitin-Protein Ligases