Preparation of 7-alkylamino-2-methylquinoline-5,8-diones.
Several novel 7-alkylamino-2-methylquinoline-5,8-diones (2) were synthesized from 2,5-dimethoxyaniline in five steps via the Skraup reaction followed by demethylations, oxidative bromination, amination, and debromination. We have achieved an unusual hydrobromic acid catalyzed debromination reactions of several 6-bromo-7-alkylamino-2-methylquinoline-5,8-diones, giving 7-alkylamino-2-methylquinoline-5,8-diones in good yields.
Division of Applied Sciences, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 136-791, Korea.
Han Young
HY
Choi
Dong Wook
DW
Kim
Dae Yoon
DY
Chi
Eun Young
EY
Yoon
Dong Jin
DJ
Kim