A role for peroxisomes in photomorphogenesis and development of Arabidopsis.
The nuclear protein DET1 is a central repressor of photomorphogenesis in plants. We have identified the molecular lesion in ted3, a mutation that dominantly suppresses the phenotypes of det1-1. TED3 encodes a peroxisomal protein (AtPex2p) essential for Arabidopsis growth. Developmental defects and the abnormal expression of many genes in det1 are rescued by ted3. ted3 also partially suppresses another pleiotropic de-etiolated mutant cop1. Thus, peroxisomes, whose functions are still largely unexplored, play a key role in a photomorphogenetic pathway negatively regulated by the DET1 and COP proteins.
Plant Biology Laboratory, Howard Hughes Medical Institute, Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Jianping
J
Hu
Maria
M
Aguirre
Charles
C
Peto
Jose
J
Alonso
Joseph
J
Ecker
Joanne
J
Chory
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D029681:Arabidopsis Proteins / Q000032:analysis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D003433:Crosses, Genetic; D003624:Darkness; D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D016153:Genes, Suppressor; D018546:Hypocotyl / Q000254:growth & development; D007211:Indoles / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008027:Light; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D000074401:Peroxins; D020675:Peroxisomes / Q000737:chemistry / Q000502:physiology*; D018517:Plant Roots / Q000254:growth & development; D030821:Plants, Genetically Modified; D011993:Recombinant Fusion Proteins; D014170:Transformation, Genetic; D044767:Ubiquitin-Protein Ligases
D029681:Arabidopsis Proteins; D002352:Carrier Proteins; C088435:DET1 protein, Arabidopsis; D007211:Indoles; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D000074401:Peroxins; D011993:Recombinant Fusion Proteins; C462525:TED3 protein, Arabidopsis; C014612:indolebutyric acid; C471983:AT2G32950 protein, Arabidopsis; D044767:Ubiquitin-Protein Ligases