Mechanisms of amnestic effect of ergot alkaloid agroclavin.
Neurochemical mechanisms of the effect of agroclavin on spatial memory in the Morris water maze in mice were studied by analyzing the effect of neurotransmitter receptor ligands on the amnestic effect of this alkaloid. D1-receptor agonist SKF-38393 and calcium channel blockers verapamil and nimodipine abolished the negative effect of agroclavin on spatial memory. The role of intracellular calcium in the mechanisms of amnestic effect of agroclavin is discussed.
Bobkova
N V
NV
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino. nbobkova@mail.ru
Uteshev
V K
VK
Medvinskaya
N I
NI
Nesterova
I V
IV
Arinbasarov
M U
MU
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D018491:Dopamine Agonists / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology*; D018782:Maze Learning; D051379:Mice; D017447:Receptors, Dopamine D1 / Q000819:agonists
D018491:Dopamine Agonists; D004873:Ergolines; D017447:Receptors, Dopamine D1; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; C004465:agroclavine