[Association between early-onset coronary heart disease and angiotensin II type 1 receptor gene polymorphism].
OBJECTIVE
To study the association between early-onset coronary heart disease (CHD) and angiotensin II type 1 receptor (ATIR) gene A1166/C polymorphism and the effect of ATIR gene A1166/C on the plasma lipid level.


METHODS
The ATIR A1166/C genotype of 71 early-onset CHD patients, 76 late-onset CHD patients, and 119 controls was examined by PCR-RFLP. Their plasma lipid levels were detected.


RESULTS
Two ATIR genotypes, AC and AA, were detected. The frequencies (97.2% vs 92.1% vs 94.1%) of genotypes AA and AC and the frequencies of allele A and allele C in the three groups were similar. No difference were found among the levels of plasma lipids in the group of early-onset CHD patients with AA (94.1% vs 5.9%) or AC genotypes (2.8% vs 7.9%).


CONCLUSIONS
There is no association between between ATIR gene A1166/C polymorphism and occurrence of early-onset CHD. ATIR geng A1166/C polymorphism has no effect on plasma lipid levels.
Department of Cardiology, Third Affiliated Hospital of Jinan University Medical College, Zhuhai Municipal People's Hospital, Zhuhai 519000, China.
Jian
J
Peng
Shu
S
Peng
Wuxing
W
Gong
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000235:genetics*
D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin