Protective effect of calcium channel blocker verapamil on morphological and functional state of hair cells of the organ of corti in experimental kanamycin-induced ototoxicity.
The protective effect of verapamil against acute ototoxic sensorineural damage produced by intraperitoneal injections of kanamycin (50 mg/kg daily for 14 day) was studied on rats. The functional (otoacoustic emission), histological, and physiological methods proved the protective effect of daily injections of calcium channel blocker verapamil (2 mg/kg) on the state of hair cells of the organ of Corti.
Zhuravskii
S G
SG
Laboratory of Hearing and Speech, I. P. Pavlov State Medical University, St. Petersburg. serge@gnwolfs.spb.org
Lopotko
A I
AI
Tomson
V V
VV
Ivanov
A G
AG
Chomskii
A N
AN
Nurskii
K V
KV
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003638:Deafness / Q000139:chemically induced*; D007612:Kanamycin / Q000633:toxicity*; D008297:Male; D009925:Organ of Corti / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D007612:Kanamycin; D014700:Verapamil