When cells become depressed: focus on neural stem cells in novel treatment strategies against depression.
Clinical neuroscience enters a new era in understanding the pathophysiology of depressive illness and the mode of action of antidepressant therapy. While elucidation of factors that lead to depression is still in its infancy, biochemical malfunctions appear to have well defined morphological correlations, especially in the hippocampus. Hippocampus is one of the main sites in the brain habouring neural stem cells. Cytokines and neurotrophic factors like brain-derived neurotrophic factor (BDNF) play a pivotal role in neural plasticity and potentially influence growth and migration of these progenitors. Not surprisingly, antidepressant drugs interfering with neurotransmitters such as serotonin (5-HT) influence neurotrophins like BDNF, since 5-HT homeostasis is essential for brain development, neurogenesis, and neuroplasticity as well as complex behavior. In this review, the new area of neural stem cell research and the avenues of ongoing and future research sustaining the development of novel treatments for depression will be explored.
Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Federal Republic of Germany. jens.benninghoff@mail.uni-wuerzburg.de
J
J
Benninghoff
A
A
Schmitt
R
R
Mössner
K-P
KP
Lesch
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D003863:Depression / Q000503:physiopathology* / Q000628:therapy*; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*
D000928:Antidepressive Agents