Tau function and dysfunction in neurons: its role in neurodegenerative disorders.
Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.
Centro de Biología Molecular (CSIC-UAM), Universidad Autónoa, Madrid, Spain. javila@cbm.uam.es
Jesús
J
Avila
Filip
F
Lim
Francisco
F
Moreno
Carlos
C
Belmonte
A Claudio
AC
Cuello
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology / Q000502:physiology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
D016875:tau Proteins