Carvone and perillaldehyde interfere with the serum-induced formation of filamentous structures in Candida albicans at substantially lower concentrations than those causing significant inhibition of growth.
Carvone and perillaldehyde were shown to inhibit the transformation of Candida albicans to a filamentous form at concentrations far lower and more biologically relevant than the concentrations necessary to inhibit growth. This morphological transformation is associated with C. albicans pathogenicity; hence these naturally occurring monoterpenes are potential lead compounds in the development of therapeutic agents against C. albicans infection.
McGeady
Paul
P
Department of Chemistry, Clark Atlanta University, 266 Lee Street, Atlanta, Georgia 30314, USA. pmcgeady@cau.edu
Wansley
Daniel L
DL
Logan
David A
DA
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001769:Blood; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects / Q000472:pathogenicity; D000081005:Cyclohexane Monoterpenes; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; C033342:perillaldehyde; C006923:carvone