The use of intravenous recombinant hirudin in the treatment of deep vein thrombosis in a patient with an acute heparin allergy.
We report a case in which intravenous heparin, given for the treatment of acute deep vein thrombosis, precipitated an acute allergic reaction, and an alternative anticoagulant, recombinant hirudin, provided rapid and successful therapeutic intervention.
Department of Internal Medicine, Bi-County Community Hospital, Henry Ford Health Systems, Warren, MI, USA. robertfields@yahoo.com
Robert M
RM
Fields
William
W
Peppo
D004342:Drug Hypersensitivity / Q000209:etiology; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006493:Heparin / Q000009:adverse effects; D024764:Hirudin Therapy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000188:drug therapy*
D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D006493:Heparin