Altered central sensorimotor processing in patients with complex regional pain syndrome.
Alterations in tactile sensitivity are common in patients with chronic pain. Recent brain imaging studies have indicated that brain areas activated by acute experimental pain partly overlap with areas processing innocuous tactile stimuli. However, the possible effect of chronic pain on central tactile processing has remained unclear. We have examined, both clinically and with whole-head magnetoencephalography, six patients suffering from complex regional pain syndrome (CRPS) of the upper limb. The cortical somatosensory responses were elicited by tactile stimuli applied to the fingertips and the reactivity of spontaneous brain oscillations was monitored as well. Tactile stimulation of the index finger elicited an initial activation at 65 ms in the contralateral SI cortex, followed by activation of the ipsi- and contralateral SII cortices at about 130 ms. The SI responses were 25-55% stronger to stimulation of the painful than the healthy side. The distance between SI representations of thumb and little finger was significantly shorter in the hemisphere contralateral than ipsilateral to the painful upper limb. In addition, reactivity of the 20-Hz motor cortex rhythm to tactile stimuli was altered in the CRPS patients, suggesting modified inhibition of the motor cortex. These results imply that chronic pain may alter central tactile and motor processing.
Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, P.O. Box 2200, FIN-02015 HUT, Espoo, Finland Department of Physiatry, ORTON Hospital, FIN-00280 Helsinki, Finland Division of Clinical Neurophysiology, Helsinki University Central Hospital, FIN-00290 Helsinki, Finland.
Kirsi
K
Juottonen
Maarit
M
Gockel
Teija
T
Silén
Heikki
H
Hurri
Riitta
R
Hari
Nina
N
Forss
D000328:Adult; D020918:Complex Regional Pain Syndromes / Q000503:physiopathology*; D005260:Female; D005385:Fingers / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods / Q000706:statistics & numerical data; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods / Q000706:statistics & numerical data; D010812:Physical Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*