The renal type IIa Na/Pi cotransporter: structure-function relationships.
The type IIa Na/Pi cotransporter mediates proximal tubular brush-border membrane secondary active phosphate (Pi) flux. It is rate limiting in tubular Pi reabsorption and, thus, a final target in many physiological and pathophysiological situations of altered renal Pi handling. In the present short review, we will briefly summarize our current knowledge about the transport mechanism (cycle) as well as particular regions of the transporter protein ("molecular domains") that potentially determine transport characteristics.
Murer
Heini
H
Physiologisches Institut, Universität Zürich, Switzerland. hmurer@access.unizh.ch
Köhler
Katja
K
Lambert
Georg
G
Stange
Gert
G
Biber
Jürg
J
Forster
Ian
I
D000595:Amino Acid Sequence; D000818:Animals; D001693:Biological Transport, Active; D003545:Cysteine / Q000235:genetics / Q000378:metabolism; D004220:Disulfides / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007687:Kidney Tubules, Proximal / Q000502:physiology; D008871:Microvilli / Q000378:metabolism; D008961:Models, Structural; D016297:Mutagenesis, Site-Directed; D010710:Phosphates / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012964:Sodium / Q000378:metabolism; D050608:Sodium-Phosphate Cotransporter Proteins; D050613:Sodium-Phosphate Cotransporter Proteins, Type IIa; D013329:Structure-Activity Relationship; D027981:Symporters / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D004220:Disulfides; D010710:Phosphates; D011993:Recombinant Fusion Proteins; C493554:SLC34A1 protein, human; D050608:Sodium-Phosphate Cotransporter Proteins; D050613:Sodium-Phosphate Cotransporter Proteins, Type IIa; D027981:Symporters; D012964:Sodium; D003545:Cysteine