Absence of painful neuropathy after chronic oral fluoride intake in Sprague-Dawley and Lou/C rats.
The possibility that chronicle oral ingestion of fluoride-rich water could modify peripheral pain sensitivity was studied in two strains of adult rats, Sprague-Dawley and Lou/C rats. Sodium fluoride was given orally in water to male Sprague-Dawley (75 and 150 ppm) and Lou rats (150 ppm) for 15 and 27 weeks, respectively. Using classical behavioural evaluation methods of pain symptoms, only slight tendencies to a thermal hyperalgia and a mechanical allodynia were observed in Sprague-Dawley rats.
Laboratoire de Toxicologie, INSERM E9904, Faculté de Pharmacie, 28, place Henri Dunant, BP 38, 63001, Clermont-Ferrand Cedex, France.
David
D
Balayssac
Damien
D
Richard
Nicolas
N
Authier
Alain
A
Nicolay
Didier
D
Jourdan
Alain
A
Eschalier
François
F
Coudoré
D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*; D014867:Water
D018712:Analgesics, Non-Narcotic; D014867:Water; D012969:Sodium Fluoride