Gender differences in depression.
Depression is twice as common in women as in men, although some concern has been raised in terms of misdiagnosing depression in men. The incidence of depression in women varies during the life span. The peak incidence during childbearing years appears to be associated with cyclic hormonal changes. Women also present with reproductive -specific mood disorders: pre-menstrual dysphoric disorder (PMDD), depression in pregnancy, postpartal mood disorder (PDD) and perimenopausal depressive disorder. Gender differences were repeatedly observed in response to antidepressant medication. Premenopausal women appear to respond poorly and to show low tolerability to TCAs, but they tend to show greater responsiveness to the SSRIs. In contrast, men and postmenopausal women can respond equally to the TCAs and SSRIs. These differences are contributed to gender differences in pharmacokinetics of antidepressants and to the influence of menstrual cycle. These findings suggest the need for a gender-specific approach to the evaluation and management of depression.
Sagud
M
M
Department of Psychiatry, University Hospital Center Zagreb, Croatia.
Hotujac
Lj
Lj
Mihaljević-Peles
A
A
Jakovljević
M
M
D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D019052:Depression, Postpartum / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000523:psychology; D011247:Pregnancy; D011248:Pregnancy Complications; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D012727:Sex Characteristics; D012737:Sex Factors
D000928:Antidepressive Agents