Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.
Institute for Health Sciences, Tokushima Bunri University, Yamashiro-chi, Tokushima-city, 770-8514, Japan.
N
N
Katunuma
H
H
Tsuge
M
M
Nukatsuka
M
M
Fukushima
D000818:Animals; D002401:Cathepsin B / Q000037:antagonists & inhibitors / Q000737:chemistry; D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D002460:Cell Line; D003546:Cysteine Endopeptidases; D004852:Epoxy Compounds / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008956:Models, Chemical; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism*; D010024:Osteoporosis / Q000378:metabolism*; D011487:Protein Conformation; D011725:Pyridines / Q000494:pharmacology; D013997:Time Factors; D014407:Tumor Cells, Cultured
C402823:CLIK 148; D004852:Epoxy Compounds; D011725:Pyridines; D002403:Cathepsins; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; C534281:CTSL protein, human; D056668:Cathepsin L; C534278:Ctsl protein, mouse