Changes in LPLa and reverse cholesterol transport variables during 24-h postexercise period.
We investigated the time course of exercise-induced lipoprotein lipase activity (LPLa) and reverse cholesterol transport (RCT) during the 24-h postexercise period. Subjects were 10 sedentary normolipidemic males [NTG; fasting triglyceride (TG) = 89.1 +/- 8.6 mg/dl] and 6 hyperlipidemic males (HTG; fasting TG = 296.8 +/- 64.0 mg/dl). Each subject performed a control trial (no exercise) and 4 exercise trials. In the exercise trials, a subject jogged on a treadmill at 60% of his maximal O(2) consumption for 1 h. Pre- and postheparin blood samples were taken before exercise (baseline) and at 4, 8, 12, and 24 h after exercise. There was no group difference in LPLa (P > 0.05) over the time points. When the LPLa data from the two groups were combined, LPLa at 24 h after exercise was higher than baseline or at 4, 8, 12 h after exercise (P < 0.05). Plasma TG and lecithin-cholesterol acyltransferase activity (LCATa) were higher in HTG than in NTG, and the total high-density lipoprotein-cholesterol (HDL(tot)-Chol) was lower in HTG than in NTG (P < 0.05). HDL(2)-Chol, LCATa, and cholesterol ester transfer protein activity did not differ during the 24-h postexercise period (P > 0.05). These results suggest that LPLa is still increasing 24 h after an acute aerobic exercise and that the magnitude of the increase in exercise-induced LPLa in HTG was similar to that in NTG. Furthermore, in the sedentary population with or without HTG, the variables related to RCT do not change during the 24-h period after exercise.
Department of Health and Kinesiology, University of Texas at San Antonio, San Antonio, Texas 78249, USA. jzhang@utsa.edu
John Q
JQ
Zhang
Bryan
B
Smith
Melissa M
MM
Langdon
Heidi L
HL
Messimer
Grace Y
GY
Sun
Richard H
RH
Cox
Marilyn
M
James-Kracke
Tom R
TR
Thomas
D000328:Adult; D001692:Biological Transport / Q000502:physiology; D002788:Cholesterol Esters / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D002940:Circadian Rhythm; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D012016:Reference Values
D002788:Cholesterol Esters; D008076:Cholesterol, HDL; D008071:Lipoprotein Lipase