Novel HLA-DRB1 alleles revealed by sequencing based typing, DRB1*04053 and DRB1*1143.
We report the discovery of two HLA-DRB1 alleles by sequencing based typing (SBT). DRB1*04053 differs from previously reported DRB1 alleles by a single synonymous nucleotide substitution, resulting in a unique polymorphism at codon 93. DRB1*1143 differs from previously identified DRB1 alleles by a single non-synonymous nucleotide substitution, resulting in a polymorphism observed in other DRB1 and DRB3 alleles1.
Molecular Genetics Laboratory, Tissue Typing Services, Australian Red Cross Blood Service, Sydney, Australia. wgreville@arcbs.redcross.org.au
W D
WD
Greville
G
G
Chapman
J-P
JP
Hogbin
H
H
Dunckley
D000483:Alleles; D001483:Base Sequence; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data
C471445:HLA DRB1*04:05:03 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C471446:HLA-DRB1*11:43 antigen