Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man.
Trait dissociation might influence the response to panicogens in normal controls. The behavioral effects of 25 microg of cholecystokinin tetrapeptide (CCK-4) were studied in 18 healthy men, nine each with high or low trait dissociation. Subjects with high trait dissociation showed a significantly lower increase of acute dissociative, anxiety and panic symptoms compared with subjects with low trait dissociation. Trait dissociation should be assessed in further behavioral challenge studies as a potentially important covariate.
Kellner
Michael
M
Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany. kellner@uke.uni-hamburg.de
Yassouridis
Alexander
A
Hua
Yun
Y
Wendrich
Mona
M
Naber
Dieter
D
Wiedemann
Klaus
K
D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis*; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006304:Health Status; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000139:chemically induced* / Q000175:diagnosis; D012720:Severity of Illness Index; D013758:Tetragastrin / Q000009:adverse effects*
D005765:Gastrointestinal Agents; D013758:Tetragastrin