Idiopathic intracranial hypertension with primary aldosteronism: report of 2 cases.
Although unconfirmed, the syndrome idiopathic intracranial hypertension (IIH), commonly seen in overweight 20- to 50-year-old women, has been proposed to have its origins in an endocrine-based disturbance of electrolytes. Herein we report on 2 women with IIH and primary aldosteronism (PAL). Aged 57 and 55 (patients 1 and 2), each had a longstanding history of mild-to-moderate arterial hypertension, recurrent hypokalemia, and headaches. They were found to have IIH at ages 51 and 45. PAL was diagnosed at ages 57 and 35, respectively, due to proven left adrenal adenoma in patient 1; and presumptive adrenal nodular hyperplasia in patient 2. This is the first report to appear in the English medical literature that describes an association between IIH and PAL. It raises the prospect that in some cases of IIH associated with arterial hypertension, an autonomous production of aldosterone should be considered.
Weber
Karl T
KT
University of Missouri Health Sciences Center, Columbia, USA. ktweber@utmem.edu
Singh
Karan D
KD
Hey
J Christopher
JC
D000236:Adenoma / Q000150:complications; D000310:Adrenal Gland Neoplasms / Q000150:complications; D000311:Adrenal Glands / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000150:complications; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology; D006965:Hyperplasia / Q000150:complications; D006973:Hypertension / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D008875:Middle Aged; D011559:Pseudotumor Cerebri / Q000209:etiology*; D012008:Recurrence