Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage.
Feeding a high carbohydrate diet induces transcription of more than 15 genes involved in the metabolic conversion of glucose to fat. A new transcription factor binding to a glucose response element of the pyruvate kinase and lipogenesis enzyme genes was discovered recently. This factor, termed carbohydrate responsive element-binding protein (ChREBP), is activated in response to high glucose and up-regulates these genes. Cyclic AMP and a high fat diet inhibit ChREBP and slow down glucose utilization. ChREBP is able to control transcription of lipogenic enzyme genes in response to nutritional and hormonal inputs, and may play an important role in disease states such as diabetes, obesity, and hypertension.
Uyeda
Kosaku
K
Department of Biochemistry, Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, 75216, USA. kuyeda6400@aol.com
Yamashita
Hiromi
H
Kawaguchi
Takumi
T
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005223:Fats / Q000378:metabolism*; D005227:Fatty Acids / Q000494:pharmacology; D005934:Glucagon / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D009747:Nutritional Physiological Phenomena / Q000502:physiology; D051780:Sterol Regulatory Element Binding Protein 1; D013261:Sterols / Q000096:biosynthesis; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D005223:Fats; D005227:Fatty Acids; C442825:Mlxipl protein, rat; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D013261:Sterols; D014157:Transcription Factors; D004247:DNA; D005934:Glucagon; D005947:Glucose