Dacryoadenitis as the earliest presenting manifestation of systemic Wegener's granulomatosis.
OBJECTIVE
To report a case presenting with dacryoadenitis as the earliest manifestation of systemic Wegener's granulomatosis (WG).


METHODS
Observational case report.


METHODS
A 41-year-old woman initially presented symptoms of bilateral dacryoadenitis. She subsequently developed upper and lower respiratory tract involvement, scleritis and keratitis.


RESULTS
Cytoplasmic antineutrophil antibody (c-ANCA) titer was positive. The lacrimal gland and lung biopsies were consistent with WG. The patient responded well to cyclophosphamide and prednisolone.


CONCLUSIONS
Dacryoadenitis maybe the earliestpresenting manifestation of WG andprompt immunosuppressive chemotherapy may control it preventing the limited disease from progressing to a complete form and reducing its morbidity and mortality.
Ophthalmology Department and Eye Research Labbafinejad Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. Labbafi@hotmail.com
M
M
Soheilian
A
A
Bagheri
M
M
Aletaha
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003607:Dacryocystitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D015423:Scleritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology
D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone