Elucidation of solid-state complexation in ground mixtures of cholic acid and guest compounds.
The solid-state complexation between cholic acid (CA) and either methyl p-hydroxybenzoate (MPB) or ibuprofen (IBP) was investigated. Powder X-ray diffractometry, IR spectroscopy and thermal analysis suggested the complex formation between CA and MPB as well as between CA and IBP by co-grinding method. The stoichiometry of CA-MPB was 1 : 1 while that of CA-IBP was 2 : 1, reflecting the effect of guest size on complex formation. The guest compounds were assumed to be included in the channel of complexes formed by hydrogen bonds among CA molecules.
Oguchi
Toshio
T
Graduate School of Pharmaceutical Sciences, Chiba University, Japan. toguchi@p.chiba-u.ac.jp
Tozuka
Yuichi
Y
Hanawa
Takehisa
T
Mizutani
Mayuko
M
Sasaki
Nahomi
N
Limmatvapirat
Sontaya
S
Yamamoto
Keiji
K
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D019826:Cholic Acid / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004055:Differential Thermal Analysis; D004339:Drug Compounding; D007052:Ibuprofen / Q000737:chemistry; D010226:Parabens / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D010226:Parabens; C015358:methylparaben; D019826:Cholic Acid; D007052:Ibuprofen