Development of gonadotropin-releasing hormone-1 neurons.
Gonadotropin releasing hormone-1 (GnRH-1) neurons, critical for reproduction, are derived from the nasal placode and migrate into the brain during prenatal development. Once within the brain, GnRH-1 cells become integral components of the CNS-pituitary-gonadal axis, essential for reproductive maturation and maintenance of reproductive function in adults. This review focuses on the lineage and development of the GnRH-1 neuroendocrine system. Although the migration of these cells from nose to brain has been well documented in a variety of species, many questions remain concerning the melecules and cues directing GnRH-1 cell differentiation, migration, axon targeting, and establishment and control of GnRH-1 secretion. These process most likely involve multiple and redundant cues because if these mechanisms fail, reproduction dysfunction will ensue and guarantee that this defect does not remain in the gene pool.
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5A-21, Bethesda, MD 20892-4156, USA. swray@codon.gov
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D000818:Animals; D001921:Brain / Q000196:embryology*; D002460:Cell Line; D002465:Cell Movement; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology; D004625:Embryo, Nonmammalian; D005314:Embryonic and Fetal Development; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000196:embryology*; D009833:Olfactory Pathways / Q000196:embryology; D020033:Protein Isoforms / Q000378:metabolism
D020033:Protein Isoforms; D007987:Gonadotropin-Releasing Hormone