Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression.
Growing evidence suggests that G-proteins may be involved in pathogenesis and treatment of affective disorders. Several studies have reported altered levels and/or activities of stimulatory G-proteins in depression. The aim of this study was to investigate whether a polymorphism in the stimulatory alpha subunit of G-proteins (T/C point mutation in exon 5; ATT --> ATC at codon 131) is associated with major depression or response to antidepressant treatment. Therefore, we performed a case-control association study with 212 depressive patients and 137 healthy, unrelated controls. There was no evidence for an association between the investigated polymorphism in the G(alpha)(s) gene and major depression, as well as to treatment response. The results of our study are in concordance with recently published findings which do not support the hypothesis that the gene for the stimulatory alpha subunit of G-proteins is a major susceptibility factor in the pathophysiology of major depression.
Zill
Peter
P
Psychiatric Hospital of the Ludwig-Maximilians-University, Munich, Germany. Peter.Zill@psy.med.uni-muenchen.de
Baghai
Thomas C
TC
Zwanzger
Peter
P
Schüle
Cornelius
C
Minov
Christo
C
Behrens
Stefanie
S
Rupprecht
Rainer
R
Möller
Hans-Jürgen
HJ
Engel
Rolf
R
Bondy
Brigitta
B
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide
D019205:GTP-Binding Protein alpha Subunits, Gs