Potential cardioprotective actions of no-releasing aspirin.
The use of low doses of aspirin on a daily basis has increased greatly in the past 20 years, based on observations that it can significantly reduce the risk of heart attacks and strokes. However, aspirin can also cause severe damage to the stomach. A modified version of aspirin that releases nitric oxide has been developed that seems to offer important advantages over its 103-year-old parent--namely, improved protection for the heart without the unwanted effects on the stomach.
Department of Pharmacology & Therapeutics, University of Calgary, Calgary, Alberta, T2N 4N1 Canada. wallacej@ucalgary.ca
John L
JL
Wallace
Louis J
LJ
Ignarro
Stefano
S
Fiorucci
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001161:Arteriosclerosis / Q000188:drug therapy; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D061945:Caspase Inhibitors; D002448:Cell Adhesion / Q000187:drug effects; D006152:Cyclic GMP / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis; D006321:Heart / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009203:Myocardial Infarction / Q000517:prevention & control*; D020521:Stroke / Q000517:prevention & control*
D061945:Caspase Inhibitors; D016207:Cytokines; C102148:nitroaspirin; D006152:Cyclic GMP; D001241:Aspirin