Inhaled sodium fluoride decreases airway responsiveness to acetylcholine analogs in vivo.
The study was conducted to characterize the action of NaF, which had relaxing property in carbachol precontracted isolated bovine bronchus, on airway responsiveness challenged by acetylcholine receptor agonists in rats and asthmatic humans. Tracheal flow rate and airway resistance were measured in anaesthetized rats. NaF was delivered either before carbachol challenge or together with carbachol. Patients with mild asthma were challenged with methacholine aerosol, and NaF was delivered when FEV1 fell by more than 20%. The results indicated that: (1) in rats NaF significantly inhibited carbachol-induced bronchial constriction when inhaled prior to carbachol challenge as airway resistances in the NaF and NaF+verapamil groups were significantly lower than those in the control group; (2) NaF significantly reversed carbachol or methacholine-induced bronchial constriction in asthmatic patients. In conclusion, NaF, delivered in form of aerosol, reduced bronchial responsiveness to carbachol in rats and had a bronchodilating effect on rat and human airways precontracted by inhalation of acetylcholine analogs.
Laboratoire de Physiologie, Faculté de Victor Pachon, Université de Bordeaux 2, 146 rue Leo Saignat, 33076 Cedex, Bordeaux, France.
Weimin
W
Zhao
Sonia
S
Rouatbi
Zouhair
Z
Tabka
Hervé
H
Guénard
D000109:Acetylcholine / Q000031:analogs & derivatives; D000280:Administration, Inhalation; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D016085:Bronchoconstrictor Agents; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000008:administration & dosage*; D014700:Verapamil / Q000494:pharmacology
D016085:Bronchoconstrictor Agents; D002121:Calcium Channel Blockers; D016210:Methacholine Chloride; D002217:Carbachol; D012969:Sodium Fluoride; D014700:Verapamil; D000109:Acetylcholine