Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.
Genomewide association studies may offer the best promise for genetic mapping of complex traits. Such studies in outbred populations require very densely spaced single-nucleotide polymorphisms. In recently founded population isolates, however, extensive linkage disequilibrium (LD) may make these studies feasible with currently available sets of short tandem repeat markers, spaced at intervals as large as a few centimorgans. We report the results of a genomewide association study of severe bipolar disorder (BP-I), using patients from the isolated population of the central valley of Costa Rica. We observed LD with BP-I on several chromosomes; the most striking results were in proximal 8p, a region that has previously shown linkage to schizophrenia. This region could be important for severe psychiatric disorders, rather than for a specific phenotype.
Neurogenetics Laboratory, University of California, San Francisco, CA, USA.
Roel A
RA
Ophoff
Michael A
MA
Escamilla
Susan K
SK
Service
Mitzi
M
Spesny
Dar B
DB
Meshi
Wingman
W
Poon
Julio
J
Molina
Eduardo
E
Fournier
Alvaro
A
Gallegos
Carol
C
Mathews
Thomas
T
Neylan
Steven L
SL
Batki
Erin
E
Roche
Margarita
M
Ramirez
Sandra
S
Silva
Melissa C
MC
De Mille
Penny
P
Dong
Pedro E
PE
Leon
Victor I
VI
Reus
Lodewijk A
LA
Sandkuijl
Nelson B
NB
Freimer
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D003364:Costa Rica; D005260:Female; D005819:Genetic Markers; D015894:Genome, Human; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D005819:Genetic Markers