ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum.
Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC(50) = 4.8 microg/mL) and KB cells (IC(50) = 1.6 microg/mL).
PROPLAME-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, Universidad de Buenos Aires (1428), Buenos Aires, Argentina.
E
E
Mongelli
A B
AB
Pomilio
J Bustamante
JB
Sánchez
F M
FM
Guerra
G Martínez
GM
Massanet
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D007928:Lethal Dose 50; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D004224:Diterpenes; C014341:argyrophilic acid