Incidence, outcome, and long-term consequences of herpes simplex virus type 1 reactivation presenting as a facial rash in intubated adult burn patients treated with acyclovir.
BACKGROUND
Increased mortality, extensive visceral involvement, and necrotizing tracheobronchitis associated with herpes viruses have been reported after burns. It is unclear whether herpes presenting as a facial rash results in outcome changes after burns.


METHODS
A retrospective study characterizing the incidence, presentation, and outcome of 14 patients with facial herpes rashes out of 95 severely burned intubated adults was performed.


RESULTS
Facial rashes attributed to herpetic infections were found in at least 15% of patients. The problem was recognized during the second week after burn. There was no difference in mortality or length of stay noted between patients with or without the infection.


CONCLUSIONS
The course of this infection was relatively benign in this group of acyclovir-treated patients. Even so, the lesions clearly contributed to patient discomfort and often produced fevers requiring costly investigations. Early recognition could help prevent diffuse spread of the lesions, decreasing patient discomfort and improving patient care.
Sumner Redstone Burn Center, Harvard Medical School, Boston, Massachusetts, USA.
Philip E
PE
Fidler
Bonnie T
BT
Mackool
David A
DA
Schoenfeld
Maryanne
M
Malloy
John T
JT
Schulz
Robert L
RL
Sheridan
Colleen M
CM
Ryan
D000212:Acyclovir / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001830:Body Surface Area; D001900:Boston / Q000453:epidemiology; D002053:Burn Units; D002056:Burns / Q000145:classification / Q000150:complications* / Q000628:therapy; D005148:Facial Dermatoses / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D006561:Herpes Simplex / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006769:Hospitals, General; D006801:Humans; D015994:Incidence; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007902:Length of Stay / Q000706:statistics & numerical data; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014775:Virus Activation
D000998:Antiviral Agents; D000212:Acyclovir