Epidural anaesthesia and analgesia - effects on surgical stress responses and implications for postoperative nutrition.
BACKGROUND
Surgical injury leads to an endocrine-metabolic and inflammatory response with protein catabolism, increased cardiovascular demands, impaired pulmonary function and paralytic ileus, the most important release mechanisms being afferent neural stimuli and inflammatory mediators.


RESULTS
Epidural local anaesthetic blockade of afferent stimuli reduces endocrine metabolic responses, and improve postoperative catabolism. Furthermore, dynamic pain relief is achieved with improved pulmonary function and a pronounced reduction of postoperative ileus, thereby providing optimal conditions for improved mobilization and oral nutrition, and preservation of body composition and muscle function. Studies integrating continuous epidural local anaesthetics with enforced early nutrition and mobilization uniformly suggest an improved recovery, decreased hospital stay and convalescence.


CONCLUSIONS
Epidural local anaesthetics should be included in a multi-modal rehabilitation programme after major surgical procedures in order to facilitate oral nutrition, improve recovery and reduce morbidity.
Holte
K
K
Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark.
Kehlet
H
H
D015360:Analgesia, Epidural; D000767:Anesthesia, Epidural; D003289:Convalescence; D004434:Early Ambulation; D004435:Eating; D004734:Energy Metabolism; D006801:Humans; D010149:Postoperative Pain / Q000517:prevention & control; D011182:Postoperative Care / Q000379:methods*; D011506:Proteins / Q000378:metabolism; D013312:Stress, Physiological / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome
D011506:Proteins