CO-induced K(+) currents in rat glomus cells are insensitive to light unlike carotid body neural discharge and Vo(O(2)).
The hypothesis that the light sensitive properties of CO-induced chemosensory nerve (CSN) discharge and oxygen consumption of the carotid body (CB) were shared by the pre-synaptic glomus cells was tested. The light effect on K(+) currents were measured before and during perfusion of the isolated rat glomus cells with high P(CO) of 550 Torr during nomoxia (P(O(2)approximately equal 100 Torr) at extra-cellular pH 7.0 and intracellular pH 6.8 with HEPES buffer. CO increased the K(+) currents with a left ward shift of the reversal potential, which showed no light effect. Thus the K(+) permeability of the glomus cell membrane were not shared by the light-sensitive CSN discharge of the CB and oxygen consumption in the presence of high P(CO.)
Li
Jinqing
J
Department of Physiology, University Pennsylvania School of Medicine, B400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA.
Roy
Arijit
A
Mokashi
Anil
A
Lahiri
Sukhamay
S
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism*; D002344:Carotid Body / Q000166:cytology / Q000502:physiology* / Q000528:radiation effects*; D002346:Carotid Sinus / Q000294:innervation; D002628:Chemoreceptor Cells / Q000378:metabolism; D066298:In Vitro Techniques; D008027:Light; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013569:Synapses / Q000502:physiology
D002245:Carbon Dioxide; D011188:Potassium; D010100:Oxygen