Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice.
Recent reports have suggested an involvement of the brain cannabinoid system in the morphine-reward pathway. To address this question we evaluated whether CB1 receptor knockout mice would show a conditioned place preference to morphine. CB1 receptor knockout mice developed a strong place preference to 4 and 8 mg/kg morphine, similar to that in wild-type Swiss-Webster mice. This data thus does not support a contribution of the brain cannabinoid system to morphine reward.
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Onarae V
OV
Rice
Nicarter
N
Gordon
Andrew N
AN
Gifford
D000818:Animals; D002755:Choice Behavior / Q000187:drug effects* / Q000502:physiology*; D003213:Conditioning, Psychological; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000235:genetics / Q000502:physiology*
D009294:Narcotics; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D009020:Morphine