In vitro susceptibilities of zygomycetes to combinations of antimicrobial agents.
Combinations of antimicrobial agents were tested against 35 strains of zygomycetes. The interaction between amphotericin B and rifampin was synergistic or additive. Flucytosine alone was inactive and, upon combination with amphotericin B, synergy was not achieved. The combination of amphotericin B with terbinafine was synergistic for 20% of strains, and the interaction between terbinafine and voriconazole was synergistic for 44% of strains. Antagonism was not observed.
Department of Medical Microbiology, University Medical Center St. Radboud, 6500 HB Nijmegen, The Netherlands.
Eric
E
Dannaoui
Javier
J
Afeltra
Jacques F G M
JF
Meis
Paul E
PE
Verweij
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D009090:Mucorales / Q000187:drug effects*; D020096:Zygomycosis / Q000382:microbiology*
D000935:Antifungal Agents; D004338:Drug Combinations; D000666:Amphotericin B