[Prediction of the severity of damage and disruption of work ability in reaction of the body to alcohol load prior to radiation exposure in the superlethal range].
In experiments on 121 white non-linear rats, 44 Papio hamadryas and 29 Macaca fascicularis, animals' reactions on the alcohol impact (AI) and following exposure to supralethal doses were compared. The animals were intravenously injected with 5% ethanol in the glucose solution, 2.1 g/kg for rats and 0.46-0.51 g/kg for monkeys. Monkeys' response to AI was scored in four-point scale by estimating of abnormalities in motor activity, coordination of motion and changes in conditioned reflex activity. It was shown that changes in the ability of alcohol-injected rats to perform the learnt exercises in the "jump box" could be used for prediction of their response to the exposure to supralethal doses of ionizing radiation. Observing the AI-response in monkeys along with a method "function of spying for moving object" made possible to predict not only a general degree of loss of working ability but also to estimate individual impairments of spying functions. In 65% monkeys high similarity of the reactions to AI and ionizing radiation was observed.
State Research Center-Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia.
N G
NG
Darenskaia
A O
AO
Korotkevich
T S
TS
Maliutina
T A
TA
Nasonova
A I
AI
Bulgakov
D000438:Alcohols / Q000008:administration & dosage*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D008251:Macaca; D010215:Papio; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats
D000438:Alcohols