[The pathology of and the cardio-pulmonary functional changes in acute multiple pulmonary microthromboembolism in a canine model].
OBJECTIVE
To evaluate the effect of acute multiple pulmonary microthromboembolism on circulation, ventilation, lung histology, and the coagulatory and fibrinolytic functions.


METHODS
Thirteen dogs were studied, 7 in the embolism group and 6 in the control group. 10 ml of blood was withdrawn from each animal. Thrombi were formed and cut into pieces of 1 mm to 2 mm in size. The thrombi were counted, and 300 thrombi were infused at one time back to the same animal. PAP, PAWP, VO(2), DO(2), D-dimer, protein C, protein S were measured before and immediately, 30 min, 1 hour, 2 hour after embolism.


RESULTS
PAP was increased immediately after embolisation, and then decreased at 1 hour. The level of D-dimer was elevated at an early stage. Pulmonary hemorrhage, consolidation and microembolism were observed.


CONCLUSIONS
Multiple microthromboembolism caused lung injury and thrombosis. PAP was increased at the early stage, but ventilation was not affected. The level of D-dimer changed at the early stage of thromboembolism.
Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Capital University of Medical Science, Beijing 100020, China.
Yanbing
Y
Wu
Chen
C
Wang
Baosen
B
Pang
Shujie
S
Niu
Hui
H
Wang
Hongyu
H
Zhang
Xinzhi
X
Weng
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D011655:Pulmonary Embolism / Q000473:pathology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D013923:Thromboembolism / Q000473:pathology / Q000503:physiopathology*
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D