Vaccines for Proteus mirabilis in urinary tract infection.
Proteus mirabilis is a documented cause of urinary tract infection (UTI) in the complicated urinary tract. Urease-mediated urea hydrolysis is responsible for both virulence of the organism and the ability to cause urolithiasis. A urease-negative mutant of P. mirabilis is unable to initiate stone formation and colonizes the kidney at a significantly lower rate. The considerable pathology caused by P. mirabilis warrants the development of a vaccine. We have initiated the advancement of vaccine studies and have determined that the MR/P fimbria, a surface adhesin of P. mirabilis, is a promising vaccine candidate. Successful vaccination would be expected both to prevent colonization by P. mirabilis and urolithiasis.
Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 W. Baltimore Street, Room 13-009, Baltimore, MD 21201, USA.
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Li
Harry L T
HL
Mobley
D001428:Bacterial Vaccines / Q000627:therapeutic use*; D006801:Humans; D011512:Proteus Infections / Q000150:complications / Q000382:microbiology / Q000517:prevention & control*; D011513:Proteus mirabilis / Q000302:isolation & purification* / Q000472:pathogenicity; D014510:Urease / Q000378:metabolism; D014545:Urinary Calculi / Q000382:microbiology; D014552:Urinary Tract Infections / Q000150:complications / Q000382:microbiology / Q000517:prevention & control*; D014774:Virulence
D001428:Bacterial Vaccines; D014510:Urease