Epstein-Barr virus-associated smooth muscle tumour: a distinctive mesenchymal tumour of immunocompromised individuals.
immunosuppressed patients are predisposed to the development of smooth muscle tumours which show near consistent association with Epstein-Barr virus (EBV). This report describes a 37-year-old patient with acquired immunodeficiency syndrome who initially presented with two masses in the liver. Image-guided core biopsy revealed a spindle cell tumour with histological and immunological features of smooth muscle neoplasm which was shown by in situ hybridisation for EBV early RNAs to be EBV-associated. The literature on this uncommon entity is critically reviewed and the differential diagnosis is also discussed.
Department of Pathology and Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong. cheuk_wah@hotmail.com
W
W
Cheuk
Patrick C K
PC
Li
John K C
JK
Chan
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D016867:Immunocompromised Host; D017403:In Situ Hybridization; D008113:Liver Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000032:analysis; D018235:Smooth Muscle Tumor / Q000276:immunology / Q000473:pathology / Q000821:virology*
D012367:RNA, Viral