Lasalocid toxicosis is inadequately quantified for horses.
The current estimate of LD50, 21.5 mg/kg BW, for lasalocid in horses is based on an analysis of 8 data from 4 horses that died at dose levels of 15, 21, 22 and 26 mg/kg. This analysis neglected 14 data from another 6 horses that survived at dose levels of 5, 10,14, 18, 19, 25, 29 and 50 mg/kg, and so was biased by selection of data. An examination of all the data indicates they are insufficient to determine the LD50. In contrast, the whole data set suggests a lowest toxic dose of 15 mg/kg, although this estimate was based on only 1 affected animal in 8 tests from 5 to 15 mg/kg in an unbalanced experiment and thus needs confirmation.
Kronfeld
David S
DS
Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg 24061-0506, USA.
D000284:Administration, Oral; D000818:Animals; D062787:Drug Overdose / Q000175:diagnosis / Q000662:veterinary; D006734:Horse Diseases / Q000139:chemically induced / Q000175:diagnosis*; D006736:Horses; D007476:Ionophores / Q000633:toxicity*; D007832:Lasalocid / Q000633:toxicity*; D007928:Lethal Dose 50; D012016:Reference Values; D015203:Reproducibility of Results
D007476:Ionophores; D007832:Lasalocid