[Comparative study of the anti-arrhythmic activity of cardiocyclide and nibentan in hypersympathotonia and acute myocardial ischemia].
The antiarrhythmogenic and antifibrillar action of cardiocyclide and nibentan--class III antiarrhythmogens (according to the classification of Vaughan Williams) was experimentally studied on narcotized cats. The hypersympathotonia model was induced by a 30-sec stimulation of the left stellate cervical ganglion on the background of acute myocardial infarction. On this model of a ventricular disorder in the heart rhythm, cardiocyclide (2.4 mg/kg) and nibentan (0.2 mg/kg) exhibited pronounced antiarrhythmic activity. It is suggested that both drugs can be used under clinical conditions for the prophylaxis of sudden coronary death in patents with acute myocardial infarction.
Laboratory of Circulation System Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
M B
MB
Vititnova
S A
SA
Kryzhanovskiĭ
N V
NV
Kaverina
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000503:physiopathology*; D001549:Benzamides / Q000627:therapeutic use*; D002415:Cats; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology*; D013233:Stellate Ganglion
D000889:Anti-Arrhythmia Agents; D001549:Benzamides; C105049:nibentan