Intensified microbiological investigations in adult patients admitted to hospital with lower respiratory tract infections.
The objective of this study was to investigate the diagnostic yield of a programme with intensified microbiological investigations in immunocompetent adult patients with lower respiratory tract infections (LRTI). Patients in the study group were included prospectively and consecutively from September 1st 1997 to May 31st 1998 and were compared with a control group from the preceding year. A total of 67 adult patients were included in the study group and they were compared with 122 adult patients in the control group. The study group underwent fibre-optic bronchoscopy (FOB) with bronchoalveolar lavage (BAL). Only 7% in the historic control group were discharged with an aetiological diagnosis of their infections; while the diagnostic yield in the study group increased to 51% of patients. In the study group the presence of new infiltrates on chest X-ray increased the detection of a microbiological aetiology from 37% with no infiltrates to 62% with infiltrates and recent antibiotic therapy reduced the detection of a microbiological cause of infection from 61% in 36 patients who had not received antibiotic therapy to 39% in 31 patients who had received recent antibiotic therapy prior to microbiological sampling. Patients in the study group with known aetiology had higher values of inflammatory markers than patients with unknown aetiology. For Streptococcus pneumoniae infection culture and urine antigen detection were complimentary depending on recent antibiotic therapy since seven of eight culture-positive patients had not received antibiotic therapy within 72 h prior to investigation, while all four patients positive for urine antigens from S. pneumoniae had received antibiotic therapy within 72 h of urine sampling. In conclusion intensified microbiologic investigations increase the diagnostic yield from 7% to 51% of patients in the study group with an aetiologic diagnosis. Routine FOB with BAL had no apparent effect on clinical outcome and seems only justified in selected patients with severe LRTI with infiltrates on chest X-ray and signs of severe inflammation where a high diagnostic yield is achieved.
Department of Internal Medicine, Silkeborg County Hospital, Denmark. j.korsgaard@dadlnet.dk
J
J
Korsgaard
T R
TR
Rasmussen
T
T
Sommer
J K
JK
Møller
J S
JS
Jensen
M
M
Kilian
D000368:Aged; D001424:Bacterial Infections / Q000175:diagnosis* / Q000276:immunology; D001431:Bacteriological Techniques / Q000379:methods; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy; D005260:Female; D005336:Fiber Optic Technology; D006760:Hospitalization; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology*