[Association between alpha-1-antichymotrypsin gene polymorphism and cerebral hemorrhage].
OBJECTIVE
To explore the association between alpha-1-antichymotrypsin (ACT) gene A/T polymorphism and cerebral hemorrhage among Chinese people.


METHODS
The DNA of peripheral leucocytes was extracted from 220 patients with cerebral hemorrhage and 276 controls. PCR- RELP was used to determine the ACT gene polymorphism. Multiple Logistic regression was performed to explore the risk factors for cerebral hemorrhage.


RESULTS
After adjusting age, gender, alcohol drinking, smoking, education,history of diabetes mellitus and primary hypertension, the analysis showed: (1) the ACT AT and TT genotypes increased the risk of cerebral hemorrhage (OR = 2.33 and 2.17 respectively, P < 0.05), but were not associated with primary hypertension. Such association was more prevalent in hypertensive cerebral hemorrhage. (2) Primary hypertension significantly increased the risk of cerebral hemorrhage (OR = 8.17 P = 0.000). (3) A significant gene environment interaction, super multiplicative type 4 interaction, was shown between both ACT AT and TT genotypes and primary hypertension with an interaction index (r) value of 2.84 and an OR value of 15.92. A significant additive type 3 gene-environment interaction was shown between both ACT AT and TT genotypes and diabetes mellitus with an OR value of 2.89.


CONCLUSIONS
ACT gene polymorphism and primary hypertension are both independent risk factors of cerebral hemorrhage. The ACT AT and TT genotypes show a significant gene-environment interaction, however, of different types, with both primary hypertension and diabetes mellitus in the occurrence of cerebral hemorrhage.
Department of Neurology, Peking University Third Hospital, Beijing 100083, China.
Yu
Y
Fu
Ruping
R
Xie
Yinhua
Y
Wang
Dafang
D
Chen
Yan
Y
Zhang
Guoying
G
Wang
Li
L
Chen
Xiping
X
Xu
D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
D000514:alpha 1-Antichymotrypsin