Can MMTV exploit TLR4?
The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response. A recent publication proposed that the retrovirus mouse mammary tumor virus exploits the pattern-recognition receptor Toll-like receptor 4 to achieve more efficient infection.
Otten
Luc A
LA
Institute of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland. luc.otto@ib.unil.ch
Finke
Daniela
D
Acha-Orbea
Hans
H
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000821:virology; D029721:Drosophila Proteins; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology*; D051379:Mice; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology*; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D014759:Viral Envelope Proteins / Q000276:immunology
D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D014759:Viral Envelope Proteins