Pathologic features of early inflammatory bowel disease.
Often the pathologic changes of IBD are subtle and may not be present in a proportion of biopsy specimens. In cases of early disease, the changes may be missed, and additional specimens should be taken after a period of time. Modifying factors, such as prebiopsy treatment and coexisting disease, should be considered. A forum to review cases and allow for communication between gastroenterologists and pathologists is especially useful for clinicopathologic correlation and assignment of a working diagnosis to each case. Careful attention to the pathologic features of early UC and CD would be most useful when evaluating new therapies for IBD.
Department of Pathology, Division of Gastroenterology, Nutrition and Hepatology, University of Pittsburgh Medical Center, 200 Lothrop Street, PUH A610.2, Pittsburgh, PA 15213, USA.
Sydney D
SD
Finkelstein
Eizaburo
E
Sasatomi
Miguel
M
Regueiro
D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000473:pathology*
D015415:Biomarkers