Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia.
In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.
Lokugamage
Kumari
K
Hokkaido University, Sapporo, Japan.
Kariwa
Hiroaki
H
Hayasaka
Daisuke
D
Cui
Bai Zhong
BZ
Iwasaki
Takuya
T
Lokugamage
Nandadeva
N
Ivanov
Leonid I
LI
Volkov
Vladimir I
VI
Demenev
Vladimir A
VA
Slonova
Raisa
R
Kompanets
Galina
G
Kushnaryova
Tatyana
T
Kurata
Takeshi
T
Maeda
Kenji
K
Araki
Koichi
K
Mizutani
Tetsuya
T
Yoshimatsu
Kumiko
K
Arikawa
Jiro
J
Takashima
Ikuo
I
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D002353:Carrier State / Q000635:transmission / Q000662:veterinary / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D014644:Genetic Variation; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000635:transmission / Q000662:veterinary* / Q000821:virology*; D006801:Humans; D051379:Mice / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012426:Russia; D012689:Sequence Homology, Nucleic Acid
D000914:Antibodies, Viral; D004279:DNA, Viral; D012367:RNA, Viral