Fine-needle aspiration cytology of recurrent granulosa cell tumor: case report with differential diagnosis and immunocytochemistry.
We report a case of an adult-type granulosa cell tumor of the ovary which was diagnosed in a 20-yr-old woman. After a 21-yr disease-free interval, she developed a pelvic recurrence, followed by a splenic metastasis and, more recently, omental masses. This report is concerned with the fine-needle aspiration (FNA) diagnosis of the granulosa cell tumor in the latter site and corroboration of the interpretation by immunocytochemistry. Only one previous case is similar to the present one documenting the role of immunocytochemistry in the evaluation of suspected metastatic granulosa cell tumor. The cytopathologic features of metastatic granular cell tumor have been described in a limited number of previous reports.
Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University Medical Center, St. Louis, Missouri 63110, USA. Lylagan@path.wustl.edu
Lourdes R
LR
Ylagan
William D
WD
Middleton
Louis P
LP
Dehner
D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D006106:Granulosa Cell Tumor / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000096:biosynthesis; D007633:Keratins / Q000096:biosynthesis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology*; D009852:Omentum / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D013160:Splenic Neoplasms / Q000556:secondary; D014746:Vimentin / Q000096:biosynthesis
D014746:Vimentin; D007265:Inhibins; D007633:Keratins