Ion chromatographic determination of trace hydroxylamine in waste streams generated by a pharmaceutical reaction process.
Hydroxylamine is a key raw material used in a synthetic drug process at Pharmacia. Since hydroxylamine is harmful to microorganisms, concentrations above 5 ppm could interfere with the biological sewage plant performance. This necessitated the development of a sensitive analytical method for detecting low levels of hydroxylamine in the waste streams generated from the pharmaceutical process. The present report describes a cation-exchange chromatographic method coupled with pulsed amperometric detection at a gold electrode for trace analysis of hydroxylamine. This method was evaluated by generating data on the parameters of specificity, precision, linearity, recovery and sensitivity.
Fernando
Peter N
PN
Pharmacia Corporation, Skokie, IL 60077, USA.
Egwu
Ignatius N
IN
Hussain
Mumtaz S
MS
D002411:Cation Exchange Resins; D002852:Chromatography, Ion Exchange / Q000379:methods*; D004345:Drug Industry; D019811:Hydroxylamine / Q000032:analysis*; D007220:Industrial Waste; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000032:analysis*
D002411:Cation Exchange Resins; D007220:Industrial Waste; D014874:Water Pollutants, Chemical; D019811:Hydroxylamine