Role of the somatotropic axis in the mammalian metabolism.
The metabolism in mammalian is regulated by multiple levels of hormone action, with complex feedback and control mechanisms. The somatotropic axis, essentially consisting of growth hormone (GH), insulin-like growth factors (IGF-I and -II), their associated carrier proteins, and receptors, plays a key role in the control of the regulation of metabolism and physiological process. Among this axis, other hormones like insulin, leptine, glucocorticoids or thyroid hormones are involved in this mechanism by modulating GH and/or IGF-I synthesis and availability. This review summarizes the complexity of the regulation of the metabolism by the somatotropic axis using different examples such as special nutritional situations or growth promoters administration.
Biology and Biochemistry Applied Department, Animal and Microbial Biology Unit, Gembloux Agricultural University, Avenue Maréchal Juin, 13, Belgium. renaville.r@fsagx.ac.be
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Hammadi
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Portetelle
D000818:Animals; D002417:Cattle; D005246:Feedback; D015870:Gene Expression / Q000187:drug effects; D005938:Glucocorticoids / Q000008:administration & dosage; D013006:Growth Hormone / Q000008:administration & dosage / Q000235:genetics / Q000502:physiology*; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D009752:Nutritional Status; D011986:Receptors, Somatotropin / Q000235:genetics
D005938:Glucocorticoids; D018969:Insulin-Like Growth Factor Binding Proteins; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone