Encoding microcarriers: present and future technologies.
In answer to the ever-increasing need to carry out many assays simultaneously in drug screening and drug discovery, several microcarrier-based multiplex technologies have arisen in the past few years. The compounds to be screened are attached to the surface of microcarriers, which can be mixed together in a vessel that contains the target analyte. Each microcarrier has to be encoded to know which compound is attached to its surface. In this article, the methods that have been developed for the encoding of microcarriers are reviewed and discussed.
Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Kevin
K
Braeckmans
Stefaan C
SC
De Smedt
Marc
M
Leblans
Rudi
R
Pauwels
Joseph
J
Demeester
D001681:Biological Assay; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical; D005336:Fiber Optic Technology; D008863:Microspheres