Physical characterization of a chitosan-based hydrogel delivery system.
Hydrogel formation from a mixture of biocompatible chitosan, beta-glycerol phosphate, and hydroxyethyl cellulose was studied. The rheological properties of the formed hydrogels were examined using a Bohlin VOR rheometer. The effect of hydrogel composition and temperature on both the gelation rate and the elastic strength of hydrogels was investigated, from which possible hydrogel formation mechanisms were inferred. The formed hydrogels as potential vehicles for delivering pilocarpine were examined. The advantages and disadvantages of chitosan/hydroxyethyl cellulose hydrogel as a delivery system are discussed.
Boehringer-Ingelheim Pharmaceuticals, Inc., 900 Ridgebury, Ridgefield, Connecticut 06877, USA.
Jinjiang
J
Li
Zhenghe
Z
Xu
D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics*; D048271:Chitosan; D016503:Drug Delivery Systems / Q000379:methods*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D055672:Static Electricity
D002686:Chitin; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D048271:Chitosan