Damage-repair error-prone polymerases of eubacteria: association with mobile genome elements.
It is known that umuDC-like operons encoding DNA polymerase V are often found in plasmids of gamma-proteobacteria. Here we demonstrate that homologous operons are associated with mobile genomic elements in Gram-positive bacteria as well. Using the comparative analysis of transcriptional regulatory signals, we suggest that genes encoding homologs of UmuC in prophages of Bacillus subtilis and transposons of Enterococus faecalis are regulated by DinR (SOS repressor). We also predict a functional link between the polymerase V-like proteins of B. subtilis and the protein family containing YolD, YozL and YqjX.
Permina
Elizaveta A
EA
State Scientific Center GosNIIGenetika, Moscow, Russia. epermina@mail.ru
Mironov
Andrey A
AA
Gelfand
Mikhail S
MS
D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics; D001419:Bacteria / Q000235:genetics*; D001483:Base Sequence; D004249:DNA Damage; D019951:DNA Polymerase beta / Q000235:genetics; D004260:DNA Repair; D004251:DNA Transposable Elements / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D013293:Enterococcus faecalis / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics*; D020563:Gammaproteobacteria / Q000235:genetics; D006094:Gram-Positive Bacteria / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; C078202:UmuC protein, E coli; D019951:DNA Polymerase beta; C120926:DNA polymerase V, E coli; D004259:DNA-Directed DNA Polymerase; C055218:UmuD protein, E coli