Influence of stimulants on electrodermal studies in Fragile X syndrome.
Attention Deficit Hyperactivity Disorder (ADHD) is seen in the majority of children with Fragile X Syndrome (FraX). Previous work has documented an enhanced sweat response to stimuli in children with FraX compared to controls utilizing electrodermal response (EDR) measures. The present study assesses the EDRs both on and off stimulants in 19 children with ADHD and FraX compared to 17 age- and IQ-matched control patients with ADHD and developmental delays. Although the baseline EDRs were comparable between FraX patients and controls, the patients with FraX had a significant decrease in EDR amplitude and number of peaks when treated with stimulants compared to controls. This suggests that patients with FraX are more responsive to the enhancement of inhibitory systems that occur with stimulant use for ADHD. The use of a quantifiable measure, such as EDR, is recommended in future studies of treatment efficacy.
M.I.N.D. Institute, University of California Davis Health System, Sacramento, California 95817, USA. randi.hagerman@ucdmc.ucdavis.edu
Randi J
RJ
Hagerman
Lucy J
LJ
Miller
Jude
J
McGrath-Clarke
Karen
K
Riley
Edward
E
Goldson
Susan W
SW
Harris
Jody
J
Simon
Kelly
K
Church
Julie
J
Bonnell
Todd C
TC
Ognibene
Daniel N
DN
McIntosh
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003913:Dextroamphetamine / Q000627:therapeutic use; D015259:Dopamine Agents / Q000627:therapeutic use; D004558:Electric Stimulation; D005600:Fragile X Syndrome / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D007360:Intelligence; D008774:Methylphenidate / Q000627:therapeutic use*; D012879:Skin Physiological Phenomena
D000697:Central Nervous System Stimulants; D015259:Dopamine Agents; D008774:Methylphenidate; D003913:Dextroamphetamine