Discovering new genes with advanced homology detection.
Most genome annotation protocols combine ab initio predictions with transcription and homology analyses to produce reliable gene predictions but they often fail to detect many actual genes. Alternative approaches involving more sensitive homology recognition methods are playing an increasingly important role in the next stage of gene discovery. The hunt for new genes is far from over.
Li
Weizhong
W
Quorex Pharmaceuticals, 1890 Rutherford Road, Suite 200, Carlsbad CA 92008, USA. wli@quorex.com
Godzik
Adam
A
D003628:Database Management Systems; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D008390:Markov Chains; D016415:Sequence Alignment / Q000379:methods* / Q000639:trends; D017422:Sequence Analysis, DNA / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D023083:beta-Defensins / Q000235:genetics
D023083:beta-Defensins