Identification of CAG repeat-containing genes expressed in human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases.
To obtain novel candidate genes for autosomal dominant spinocerebellar ataxia and other neurodegenerative disorders in which gene mutations remain unidentified, we screened a human fetal brain cDNA library using (CAG)(10) repeat probes. Sixteen cDNAs were isolated and mapped to chromosomes 1, 2, 3, 6, 9, 13, 15, 16, 22, and X. Although we failed to detect abnormal CAG repeat expansion within these genes in Japanese patients with inherited neurodegenerative diseases, these genes remain potential candidate genes for neurodegenerative diseases that feature anticipation.
Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, 2-2-B9 Yamadaoka, Suita, Osaka 565-0871, Japan.
Masaji
M
Tachikawa
Yoshitaka
Y
Nagai
Koichiro
K
Nakamura
Kazuhiro
K
Kobayashi
Tsutomu
T
Fujiwara
Hye-Jung
HJ
Han
Yuko
Y
Nakabayashi
Yaeko
Y
Ichikawa
Jun
J
Goto
Ichiro
I
Kanazawa
Yusuke
Y
Nakamura
Tatsushi
T
Toda
D001921:Brain / Q000378:metabolism*; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000302:isolation & purification; D015723:Gene Library; D005799:Genes, Dominant; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D015345:Oligonucleotide Probes; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020754:Spinocerebellar Ataxias / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics*
D018076:DNA, Complementary; D005819:Genetic Markers; D015345:Oligonucleotide Probes