Intermediate follow-up of a composite stentless porcine valved conduit of bovine pericardium in the pulmonary circulation.
BACKGROUND
In the pediatric population, glutaraldehyde-preserved bovine pericardium conduit containing a stentless porcine valve has been proposed as an alternative to homografts for right ventricular outflow tract reconstruction.


METHODS
Between June 1996 and March 2000, a total of 55 patients, 20 with truncus arteriosus, 21 with pulmonary atresia with ventricular septal defect, and 14 with miscellaneous defects, received this conduit. Median age at implantation was 3.4 months (range, 3 days to 19 years), and 27 patients (50%) were less than 3 months old. Clinical outcome, echocardiographic data, and pathologic analysis were recorded. End points for conduit failure were conduit replacement or dilation. A mean follow-up of 27 months (range, 2 to 46 months) was available for 47 survivors.


RESULTS
Procedure for conduit obstruction was required in 13 patients. The most common procedure was operation, and all but 3 patients had an unsuccessful balloon angioplasty before reoperation. Actuarial freedom from conduit dilation or reoperation was 93.6% (95% confidence limits, 82% to 99%), 81.9% (95% confidence limits, 64% to 91%), 77.8% (95% confidence limits, 39% to 78%), and 64.3% (95% confidence limits, 26% to 73%) at 1, 2, 3, and 4 postoperative years, respectively. Univariate analysis identified small conduit size as a risk factor for conduit obstruction.


CONCLUSIONS
Although this new conduit was not free from progressive obstruction, our clinical results (easy to work and good valvular function) and the availability in small sizes encouraged us to use it as an alternative to small-size homografts when those were not available.
Aupècle
Bertrand
B
Department of Pediatric Cardiac Surgery, Hospital Marie-Lannelongue, Paris Sud University, Le Plessis Robinson, France.
Serraf
Alain
A
Belli
Emre
E
Mohammadi
Siamak
S
Lacour-Gayet
François
F
Fornes
Paul
P
Planché
Claude
C
D000293:Adolescent; D001705:Bioprosthesis; D019917:Blood Vessel Prosthesis Implantation; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular; D006330:Heart Defects, Congenital / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010496:Pericardium; D018633:Pulmonary Atresia / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014339:Truncus Arteriosus, Persistent / Q000601:surgery