Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.).
Two antiaggregant compounds, thymol (compound 1) and 3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (compound 2) were isolated from the leaves of thyme (Thymus vulgaris L.). The structures were determined by (1)H-, (13)C-NMR and mass spectra (MS) studies. These compounds inhibited platelet aggregation induced by collagen, ADP, arachidonic acid (AA) and thrombin except that compound 2 did not inhibit platelet aggregation induced by thrombin.
Kagawa Prefectural Fermentation and Food Experimental Station, 1351-1 Nouma Uchinomi-cho, Souzu-gun, Kagawa 761-4421, Japan.
Kenji
K
Okazaki
Kazuyoshi
K
Kawazoe
Yoshihisa
Y
Takaishi
D006801:Humans; D015394:Molecular Structure; D009391:Nephelometry and Turbidimetry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D046930:Thymus Plant / Q000737:chemistry*
D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors