Kidney functions in newly diagnosed type 2 diabetic subjects: role of glycemic control.
BACKGROUND
The increased urinary albumin excretion (UAE) found at the diagnosis in type 2 diabetes may at least be functional and, thus reversible, as in type 1 diabetes. Furthermore, a positive correlation has been found between the glycemic control and UAE in type 2 diabetic subjects.


METHODS
The impact of glycemic control after achieving three months of continuous normo-glycemia was studied in 26 (including 16 males and 10 females) newly diagnosed type 2 diabetic patients to assess renal size/volumes, various renal functions and UAE.


RESULTS
A significant reduction was seen in glomerular filtration rate (GFR), UAE and fractional albumin clearance after achieving near normoglycemia (p < 0.01). A decrease in the kidney size/volume, though statistically insignificant, was also observed. Besides a decline in GFR of 4.8% was also noted after three months of stable normoglycemia. UAE normalized in six of these subjects. A statistically significant correlation was also found between the changes in mean fasting plasma glucose and the decline in UAE (r=0.56 and p < 0.01).


CONCLUSIONS
The study emphasizes the necessity to correct the apparently reversible increase in microabuminuria that accompanies hyperglycemia prior to patients recruitment for intervention therapy.
Ahmad
J
J
Department of Medicine, JN Medical College, Aligarh.
Singh
M
M
Kumar
S
S
D000419:Albuminuria / Q000628:therapy; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006943:Hyperglycemia / Q000628:therapy*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose