Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. william.pitts@bms.com
William J
WJ
Pitts
Junqing
J
Guo
T G Murali
TG
Dhar
Zhongqi
Z
Shen
Henry H
HH
Gu
Scott H
SH
Watterson
Mark S
MS
Bednarz
Bang Chi
BC
Chen
Joel C
JC
Barrish
Donna
D
Bassolino
Daniel
D
Cheney
Catherine A
CA
Fleener
Katherine A
KA
Rouleau
Diane L
DL
Hollenbaugh
Edwin J
EJ
Iwanowicz
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D014227:Triazines; D007168:IMP Dehydrogenase