Glycoprotein I of varicella-zoster virus is required for viral replication in skin and T cells.
Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.
Moffat
Jennifer
J
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York 13210, USA. moffatj@mail.upstate.edu
Ito
Hideki
H
Sommer
Marvin
M
Taylor
Shannon
S
Arvin
Ann M
AM
D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D014645:Herpesvirus 3, Human / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000821:virology; D016031:Liver Transplantation; D051379:Mice; D016513:Mice, SCID; D016133:Polymerase Chain Reaction; D017384:Sequence Deletion; D012867:Skin / Q000821:virology*; D013601:T-Lymphocytes / Q000821:virology*; D013950:Thymus Gland / Q000637:transplantation / Q000821:virology; D014183:Transplantation, Heterologous; D014759:Viral Envelope Proteins / Q000502:physiology*; D014774:Virulence; D014779:Virus Replication / Q000502:physiology
D004279:DNA, Viral; D014759:Viral Envelope Proteins; C056913:glycoprotein E, varicella-zoster virus