No evidence of association between the alpha-2 macroglobulin gene and Parkinson's disease in a case-control sample.
Alpha-2 macroglobulin (A2M) is a component of Lewy bodies, a hallmark of Parkinson's disease (PD). In 159 PD patients and 190 normal controls, we studied two A2M polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism method: a five-nucleotide deletion at the 5' splice site of exon 18; and a valine to isoleucine exchange in amino acid position 1000 near the thiolester active site. No significant differences in allelic and genotypic distribution were found between cases and controls or between early and late-onset PD patients. The present data suggest that these polymorphisms do not represent a risk factor for PD and do not modulate the age at onset of PD.
Nicoletti
Giuseppe
G
Institute of Experimental Medicine and Biotechnology, National Research Council, Mangone (CS), Italy.
Annesi
Grazia
G
Tomaino
Carmine
C
Spadafora
Patrizia
P
Pasqua
Angela Aurora
AA
Annesi
Ferdinanda
F
Serra
Paolo
P
Caracciolo
Manuela
M
Messina
Demetrio
D
Zappia
Mario
M
Quattrone
Aldo
A
D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D016631:Lewy Bodies / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors; D000511:alpha-Macroglobulins / Q000235:genetics*
D000511:alpha-Macroglobulins