Promotion of cyclization of linear pentapeptides and heptapeptide by different univalent metal ions.
Univalent metal ions such as Na+, K+ and Cs+ can enhance not only the cyclization yields of some linear pentapeptides and heptapeptide but also their cyclization rates while some bivalent and trivalent metal ions such as Mg2+, Ca2+, Zn2+, Fe2+, Ni2+ and Cr3+ elevate neither the cyclization yields nor the cyclization rates and some of them prevent the cyclization.
Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Department of Chemistry, Peking University, Beijing 100871, China. yhye@pku.edu.cn
Yun-hua
YH
Ye
Mian
M
Liu
Yan-chun
YC
Tang
Xiaohui
X
Jiang
D002414:Cations, Monovalent / Q000494:pharmacology; D003500:Cyclization / Q000187:drug effects; D008670:Metals / Q000494:pharmacology*; D009842:Oligopeptides / Q000737:chemistry / Q000187:drug effects; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
D002414:Cations, Monovalent; D008670:Metals; D009842:Oligopeptides; D010456:Peptides, Cyclic