Two new subergane-based sesquiterpenes from a Taiwanese Gorgonian coral Subergorgia suberosa.
Chemical investigation of the ethyl acetate extract of the Taiwanese Gorgonian coral Subergorgia suberosa has resulted in the isolation of two new subergane-based sesquiterpenes, subergorgiol (1) and 2beta-acetoxysubergorgic acid (2), along with four known compounds, subergorgic acid methyl ester (3), 2beta-acetoxy methyl ester of subergorgic acid (4), 2beta-hydroxysubergorgic acid (5), and subergorgic acid (6). The structures of the new metabolites 1 and 2 were determined on the basis of extensive spectral analyses. Subergorgiol (1) may be the biosynthetic precursor of 2-6. Compound 3 was found to exhibit moderate cytotoxicity against the growth of HeLa cancer cells.
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
Guey-Horng
GH
Wang
Atallah F
AF
Ahmed
Yao-Haur
YH
Kuo
Jyh-Horng
JH
Sheu
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
C465811:2beta-acetoxysubergorgic acid; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C465810:subergorgiol