Targeting epidermal Langerhans cells by epidermal powder immunization.
Immune reactions to foreign or self-antigens lead to protective immunity and, sometimes, immune disorders such as allergies and autoimmune diseases. Antigen presenting cells (APC) including epidermal Langerhans cells (LCs) play an important role in the course and outcome of the immune reactions. Epidermal powder immunization (EPI) is a technology that offers a tool to manipulate the LCs and the potential to harness the immune reactions towards prevention and treatment of infectious diseases and immune disorders.
Chen
Dexiang
D
PowderJect Vaccines, Inc., Madison, WI 53711, USA. dexiang_chen@powderject.com
Payne
Lendon G
LG
D000279:Administration, Cutaneous; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000078404:Epidermal Cells; D006801:Humans; D007114:Immunization / Q000379:methods*; D007801:Langerhans Cells / Q000276:immunology / Q000378:metabolism* / Q000502:physiology*; D011208:Powders; D014612:Vaccines
D011208:Powders; D014612:Vaccines