Protein structure prediction in 2002.
Central issues concerning protein structure prediction have been highlighted by the recently published summary of the fourth community-wide protein structure prediction experiment (CASP4). Although sequence/structure alignment remains the bottleneck in comparative modeling, there has been substantial progress in fully automated remote homolog detection and in de novo structure prediction. Significant further progress will probably require improvements in high-resolution modeling.
Howard Hughes Medical Institute and Department of Biochemistry, Box 357350, University of Washington, Seattle, Washington 98165, USA.
Jack
J
Schonbrun
William J
WJ
Wedemeyer
David
D
Baker
D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein / Q000639:trends