[Rules of interactions and functional continuum of neuropeptides (on the way to the common conception)].
The biological activity of neuropeptides (NP) is extremely wide and, moreover, there are thousands of peptides. Due to the pronounced multifunctionality of each peptide and to the overlapping reduplication of bioactivity spectra of each peptide, a functionally persistent aggregate (i.e. the functional continuum of NP) is formed. The method of vector representation of NP effects is outlined, which makes it possible to classify the multitude of NP according to functional characteristics, to reveal the evolutionary rules of development of the peptide system for regulation of biological parameters, and to indicate the constellations of regulatory peptides that are the most promising to be studied from the medical point of view.
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IP
Ashmarin
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SV
Koroleva
D008433:Mathematics; D008959:Models, Neurological; D009479:Neuropeptides / Q000145:classification / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D018013:Receptors, Neuropeptide / Q000378:metabolism / Q000502:physiology*
D009479:Neuropeptides; D018013:Receptors, Neuropeptide