Flexible crosslinked benzhydryl support for gel-phase peptide synthesis.
An amphiphilic support was developed by the suspension polymerization of styrene and 1,4-butanediol dimethacrylate. The copolymer was converted to benzhydryl resin, BDDMA-PS-BH, by a two-step polymer analogous reaction. This resin was employed as a support for the synthesis of delta sleep inducing peptide (DSIP), Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, in high yield and purity by Fmoc / t-Bu tactics.
School of Chemical Sciences, Mahatma Gandhi University, Kottayam - 686 560, Kerala, India.
I M Krishna
IM
Kumar
Beena Mathew
BM
Mathew
D001559:Benzhydryl Compounds / Q000737:chemistry*; D002621:Chemistry / Q000379:methods*; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary; D013997:Time Factors
D001559:Benzhydryl Compounds; D003432:Cross-Linking Reagents; D010455:Peptides