Neonatal sepsis: evaluation and management.
Bacterial antigenic challenge presents a difficult fight for the neonatal immune system, and they have a smaller arsenal of weapons to fight bacterial infections than adults and older children. The baby's own systemic inflammatory response may have detrimental effects on several organs and longer lasting effects on the developing brain. Neurodevelopmental outcomes after maternal chorioamnionitis are worse than neonates without a contaminated intrauterine environment, regardless of gestation age and the baby's culture results. Successes with intrapartum antibiotic prophylaxis decreasing rates of GBS sepsis and maternal chorioamnionitis, have heartened care providers and parents. These results demonstrate the advances possible when specific diseases are made a national health priority, and good clinical trial work is applied to clinical practice.
Eicher
Dorothea Jenkins
DJ
MUSC Children's Hospital, 165 Ashley Ave., P.O. Box 250917, Charleston, SC 29425, USA.
Annibale
David J
DJ
D006801:Humans; D007231:Infant, Newborn; D009359:Neonatology; D011159:Population Surveillance; D017410:Practice Guidelines as Topic; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D013290:Streptococcal Infections / Q000517:prevention & control; D013292:Streptococcus agalactiae