Recent advances in the synthesis, design and selection of cysteine protease inhibitors.
Inhibition of cysteine proteases is emerging as an important strategy for the treatment of a variety of human diseases. Intense efforts involving structure-based inhibitor design have been directed toward several cysteine proteases, including cathepsin K, calpain, human rhinovirus 3C protease and several parasitic cysteine protease targets. Other successful recent efforts have involved combinatorial synthesis and screening for identification of new inhibitor templates.
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Alejandro Alvarez
AA
Hernandez
William R
WR
Roush
D000818:Animals; D002154:Calpain / Q000037:antagonists & inhibitors; D061945:Caspase Inhibitors; D020650:Combinatorial Chemistry Techniques; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D014764:Viral Proteins; D002154:Calpain