Simple, hybrid deep venous thrombosis/pulmonary embolus prophylaxis after total hip arthroplasty.
A 7.1% deep venous thrombosis rate followed total hip arthroplasty in 56 patients using a hybrid prophylactic regimen against deep venous thrombosis and pulmonary embolus. There were no bleeding complications, no symptomatic pulmonary emboli, and no unexplained deaths. The regimen consisted of an initial loading dose of warfarin, usually 10 mg, the night of surgery followed by 2.5 mg/day for 3 weeks, with dosage adjustments only in cases of over-anticoagulation. This regimen was combined with elevated sling suspension of the operative leg, bilateral pedal intermittent pneumatic compression devices, and early mobilization. This prophylactic regimen is simple, inexpensive, efficacious, and compatible with an early hospital discharge.
Department of Orthopaedic Surgery, Wake Forest University, Baptist Medical Center, Winston-Salem, NC 27157-1070, USA.
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D019644:Arthroplasty, Replacement, Hip; D029721:Drosophila Proteins; D004434:Early Ambulation; D005676:Gravity Suits; D006801:Humans; D008875:Middle Aged; D010749:Phosphoprotein Phosphatases; D010744:Phosphoric Monoester Hydrolases; D011183:Postoperative Complications; D011655:Pulmonary Embolism / Q000517:prevention & control*; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage*
D029721:Drosophila Proteins; D014859:Warfarin; C448559:ssh protein, Drosophila; D010749:Phosphoprotein Phosphatases; D010744:Phosphoric Monoester Hydrolases