Fatal group A streptococcal necrotizing fasciitis and toxic shock syndrome in a patient with psoriasis and chronic renal impairment.
A 78-year-old woman presented with rapid onset of skin pain which evolved into oedema, discoloration and infarction. She was diagnosed with group A beta-haemolytic streptococcus (Streptococcus pyogenes) necrotizing fasciitis and streptococcal toxic shock syndrome. The patient had a past history of psoriasis and end-stage renal impairment. Despite treatment with multiple antibiotics in an intensive care unit, the skin infarction involving the upper trunk continued to expand and the patient died within 24 hours of hospital admission. Group A streptococcus and Staphylococcus aureus were cultured from a tissue biopsy. Renal failure and compromised skin barrier function are known to predispose to invasive streptococcal infections, but necrotizing fasciitis has only rarely been reported in association with psoriasis. This case illustrates the fulminant nature of the infection.
Chong
Alvin H
AH
Department of Dermatology, Addenbrooke's Hospital, Cambridge, United Kingdom. alvinmary@bigpond.com
Burrows
Nigel P
NP
D000368:Aged; D000900:Anti-Bacterial Agents; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D018450:Disease Progression; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D019115:Fasciitis, Necrotizing / Q000150:complications / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D011565:Psoriasis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012772:Shock, Septic / Q000150:complications / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D013290:Streptococcal Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D013297:Streptococcus pyogenes / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents