A novel dizinc bridged hydroxamate model for hydroxamate inhibited zinc hydrolases.
Reaction of Zn(OAc)(2).2H2O with tmen leads to the formation of [Zn(tmen)(OAc)2] (I) which reacts with benzohydroxamic acid to form Zn(BA)2.H2O (II) and the novel dizinc hydroxamate bridged complex [Zn2(mu-OAc)2(OAc)(mu-BA)(tmen)] (III), which may also be prepared by self-assembly and whose structure closely mimics that of the native hydroxamate inhibited Aeromonas proteolytica aminopeptidase.
Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
David A
DA
Brown
William
W
Errington
Noel J
NJ
Fitzpatrick
William K
WK
Glass
Terence J
TJ
Kemp
Hassan
H
Nimir
Aine T
AT
Ryan
D000333:Aeromonas / Q000201:enzymology; D000626:Aminopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry*; D006877:Hydroxamic Acids / Q000138:chemical synthesis*; D018716:Molecular Mimicry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D015032:Zinc
D006877:Hydroxamic Acids; D009942:Organometallic Compounds; D011480:Protease Inhibitors; D000626:Aminopeptidases; D015032:Zinc