HLA-Cw6 specificity and polymorphic residues are associated with susceptibility among Chinese psoriatics in Taiwan.
Previous serotyping in Chinese patients has failed to confirm an association between HLA-Cw6 and psoriasis. As serotyping has proved to be less valuable in the determination of HLA-C, genotyping of HLA-C in 68 Taiwanese psoriasis vulgaris (PSV) patients was performed using polymerase chain reaction/sequence-specific oligonucleotide probe hybridization (PCR-SSOPH) of HLA-Cw genes. Compared to 213 non-PSV control subjects, HLA-Cw6 was significantly associated with PSV (16.18% of PSV patients vs 5.16% of controls; odds ratio 3.53, Pc</=10(-4)). The amino acid residues on the heavy chain of the HLA-Cw antigens from exon one to exon five were also analyzed. Asp 9, Ser 24, Ala 73, Asp 90, Trp 97, Trp 156 and Asn 77/Lys 80 were found to be positively associated with PSV ( Pc</=0.0044, 0.0008, 0.0026, 0.0014, 0.039, 0.0020 and 0.0000, respectively).
Department of Dermatology, National Taiwan University Hospital, No.7, Chang-Shan S. Rd., Taipei, Taiwan, 10016.
Tsen-Fang
TF
Tsai
Chung-Yi
CY
Hu
Wei-Ling
WL
Tsai
Chia-Yu
CY
Chu
Sung-Jan
SJ
Lin
Shwu-Huey
SH
Liaw
Bor-Luen
BL
Chiang
Pei-Jung
PJ
Lin
Shiou-Hwa
SH
Jee
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D004247:DNA / Q000235:genetics; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*; D013624:Taiwan
D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA