[Effect of acetylcholine and adenosine triphosphate on membrane potential of intact rat aorta endothelium in aging].
Changes in the electric reactions of intact endothelium of isolated rat aorta were studied in conditions of aging. A value of resting membrane potential of endothelium of old rats (24-26 mo) was significantly greater, than in control group of animals (6 mo). In responses to acetylcholine and ATP the old rats did not show a typical course of reactions, which was peculiar to control animals. Inability of old rats to produce a typical response to acetylcholine and ATP may signify a disturbance of links between endothelial cells, which resulted in functional clusterization of the latter. The data obtained suggest a possible mechanism of decrease in production and release of potent vasodilator--nitric oxide--due to changes that occur in the electric properties of endothelium in aging.
Tkachenko
M M
MM
A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Iarots'kyĭ
V V
VV
Marchenko
S M
SM
Sahach
V F
VF
D000109:Acetylcholine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D000255:Adenosine Triphosphate; D000109:Acetylcholine