Preferential enrichment: full crystallographic analysis of the unusual phenomenon in the mixed crystals' version.
Full characterization of the crystal structures of the racemate, nonracemate (20% ee), and pure enantiomer of [2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]trimethylammonium p-bromobenzenesulfonate (NBMe3), which has successfully shown an unusual enantiomeric resolution phenomenon, "preferential enrichment," was achieved by means of X-ray crystallographic analysis and construction of the binary melting point phase diagram. The crystalline nature of the racemate is not a racemic compound but a fairly ordered mixed crystal composed of the two enantiomers. The crystal structure of the nonracemate (20% ee) is virtually identical with that of the racemate and similar to that of the pure enantiomer. The binary melting point phase diagram of NBMe3 is consistent with the nature of a mixed crystal composed of the two enantiomers.
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.
Hiroki
H
Takahashi
Rui
R
Tamura
Daisuke
D
Fujimoto
Zsolt
Z
Lepp
Kimiko
K
Kobayashi
Takanori
T
Ushio
D018360:Crystallography, X-Ray / Q000379:methods*; D008956:Models, Chemical; D013237:Stereoisomerism; D013696:Temperature