Using genetic variation to study immunomodulation.
The generation of a draft sequence of a human genome has led to the identification of millions of common variants, known as single nucleotide polymorphisms, which constitute a resource for studying complex diseases. Currently, high-density maps of variants in candidate genes, chromosomal regions or the entire genome should encourage investigation of determinants of human immune response, using quantitative analysis. Ultimately, this approach should identify novel targets for therapeutic intervention.
Chanock
Stephen
S
Section on Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA. sc83a@nih.gov
Taylor
James G
JG
D000276:Adjuvants, Immunologic / Q000235:genetics*; D000818:Animals; D014644:Genetic Variation / Q000235:genetics* / Q000276:immunology*; D023281:Genomics / Q000379:methods; D006801:Humans; D037601:Mannose-Binding Lectin / Q000031:analogs & derivatives* / Q000235:genetics / Q000276:immunology; D020641:Polymorphism, Single Nucleotide / Q000502:physiology
D000276:Adjuvants, Immunologic; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin