Celastraceae sesquiterpenoids: biological activity and synthesis.
Plant extracts of the Celastraceae have been used for centuries throughout South America and China as insect repellents and insecticides in traditional agriculture, and also for the treatment of a plethora of medical ailments from stomach complaints and fever to rheumatoid arthritis and cancer. Many of the medicinally interesting properties associated with these crude preparations have now been attributed to a large family of highly oxygenated sesquiterpenoids based on a tricyclic dihydroagarofuran skeleton. In this article, the structural diversity and range of biological activities associated with this intriguing class of natural products are examined with a view to stimulating interest in their total synthesis. Existing synthetic endeavours towards their synthesis are also evaluated.
a.c.spivey@sheffield.ac.uk
Alan C
AC
Spivey
Matthew
M
Weston
Steven
S
Woodhead
D002455:Cell Division / Q000187:drug effects; D018432:Drug Resistance, Multiple; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019685:Rosales / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D012717:Sesquiterpenes