Human Insulinomas: Clinical, Cellular, and Molecular Aspects.
Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B-cells, discuss the new classification, the criteria of malignancy, and the clonal composition of endocrine pancreatic tumors, and outline recent findings on the molecular pathology of these tumors.
Komminoth
Paul
P
MD, PHD.
Heitz
Philipp U.
PU
Roth
Jürgen
J