Influence of maternal antibodies on efficacy of a subunit vaccine: transmission of classical swine fever virus between pigs vaccinated at 2 weeks of age.
This study shows the effectiveness of vaccination with an E2 subunit vaccine against classical swine fever (CSF) in 2-week-old piglets. Half of the piglets were carrying maternally derived antibodies (MDAs) at the time of vaccination. Three and 6 months later, antibody levels were compared between the two treatments. Moreover, reduction of virus transmission was investigated at 3 and 6 months by doing transmission experiments. The vaccine was found to be capable of reducing virus transmission significantly at both time intervals. Maternal immunity reduced vaccination-induced antibody levels after 3 and 6 months and possibly led to a less effective protection against virus transmission after 6 months.
Quantitative Veterinary Epidemiology, Institute for Animal Science and Health, P.O. Box 65, 8200 AB Lelystad, The Netherlands. d.klinkenberg@id.wag-ur.nl
D
D
Klinkenberg
R J M
RJ
Moormann
A J
AJ
de Smit
A
A
Bouma
M C M
MC
de Jong
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D006691:Classical Swine Fever / Q000276:immunology* / Q000517:prevention & control / Q000635:transmission*; D006692:Classical Swine Fever Virus / Q000276:immunology*; D005260:Female; D007112:Immunity, Maternally-Acquired; D011247:Pregnancy; D013997:Time Factors; D022223:Vaccines, Subunit / Q000494:pharmacology; D014765:Viral Vaccines / Q000494:pharmacology*
D000914:Antibodies, Viral; D022223:Vaccines, Subunit; D014765:Viral Vaccines