[Two cases of infectious mononucleosis-like syndrome associated with human herpes-virus 6].
We experienced two cases of infectious mononucleosis-like syndrome associated with human herpesvirus 6 (HHV-6). One of the patients had been under medication for depression and the other one for schizophrenia. Both of them were taking carbamazepine for more than a week along with the other drugs. The manifestation of the symptoms of those two were almost same, such as high fever, generalized eruption, liver dysfunction, lymph-adenopathy, and existence of atypical lymphocytes. Serological tests for EB virus, cytomegalovirus and herpes simplex virus showed no significant change while the tests for HHV-6 showed increased titers of IgG antibody during the courses. We also examined HHV-6 DNA by real time quantitative PCR tests for HHV-6, and they appeared significantly high in the peripheral blood samples.
Department of General Medicine, Juntendo University School of Medicine.
Shigehisa
S
Tomita
Naoto
N
Takeda
Hiroshi
H
Isonuma
Tae
T
Sato
Hiroko
H
Ohshima
Tsukasa
T
Ebe
Sakae
S
Sekiya
Takao
T
Matsumoto
Yasuo
Y
Hayashida
Kazuyoshi
K
Watanabe
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D003863:Depression / Q000188:drug therapy; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000209:etiology / Q000821:virology*; D012559:Schizophrenia / Q000188:drug therapy
D000914:Antibodies, Viral; D004279:DNA, Viral