Endothelial activation: intracellular signaling pathways.
Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.
Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06510, USA. jordan.pober@yale.edu
Jordan S
JS
Pober
D000818:Animals; D004727:Endothelium / Q000166:cytology* / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007962:Leukocytes / Q000166:cytology / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*