[An experimental study of inhibition of tetrandrine on posterior capsular opacification in rabbits].
OBJECTIVE
To study the effect of tetrandrine (Tet) on the formation of posterior capsular opacification (PCO) after cataract extraction.


METHODS
Intraocular lens implantation was performed on 48 healthy rabbit eyes, and they were randomly divided into 4 groups: control (A), dexamethasone (B), Tet (C) and Tet with coated IOL (D). Dexamethasone and Tet were postoperatively injected into the subconjunctival space. The number of cells, the contents of protein and malondialdehyde (MDA) in the aqueous were determined at different days postoperatively. The PCO was scored and opaque posterior capsules were weighted.


RESULTS
The number of cells, the amount of protein in aqueous, the scales and the wet weight of PCO in the treated eyes were less than that of the control eyes (P < 0.05). In B and C group, except the 14th day content, the postoperative MDA was lower than that in the control group (P < 0.05).


CONCLUSIONS
Tet can inhibit the formation of PCO, and has no obvious toxicity to the corneal endothelium.
Ophthalmology Department, Henan Medical University, Zhengzhou 450056, China. drzs@263.net
Linjie
L
Guo
Xiaofang
X
Zhang
Sheng
S
Zhang
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D044182:Benzylisoquinolines; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular / Q000009:adverse effects; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D044182:Benzylisoquinolines; D005938:Glucocorticoids; C009438:tetrandrine; D003907:Dexamethasone