Kinetic isotope effects on the dissolution kinetics of solid salicylic acid in aqueous solution: evidence for solubilisation via a proton dissociation-recombination mechanism.
Quantitative Atomic Force Microscopy measurements made on the dissolving surface of solid salicylic acid in H2O and D2O reveal a kinetic isotope effect (kH/kD = 2.3 +/- 0.6) on the dissolution rate consistent with a transition state in which the proton is dissociated from the dissolving molecule.
Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, UK OX1 3QZ.
Shelley J
SJ
Wilkins
Barry A
BA
Coles
Richard G
RG
Compton
D003903:Deuterium; D007700:Kinetics; D018625:Microscopy, Atomic Force / Q000295:instrumentation / Q000379:methods*; D011522:Protons; D020156:Salicylic Acid / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D014867:Water
D011522:Protons; D014867:Water; D003903:Deuterium; D020156:Salicylic Acid