Synthetic study on CP-263,114 (phomoidride B) by SET-mediated fragmentation.
Assembly of the highly functionalized carbocyclic core of CP-263,114 has been accomplished by using radical-mediated fragmentation with lithium naphthalenide as a key step.
Matsushita
Takeshi
T
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Ashida
Hiroshi
H
Kimachi
Tetsutaro
T
Takemoto
Yoshiji
Y
D003500:Cyclization; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008094:Lithium / Q000737:chemistry*; D008299:Maleic Anhydrides / Q000138:chemical synthesis*; D008958:Models, Molecular; D009281:Naphthalenes / Q000737:chemistry*; D010084:Oxidation-Reduction
C104957:CP 263114; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D008299:Maleic Anhydrides; D009281:Naphthalenes; D008094:Lithium