Protein flexibility and drug design: how to hit a moving target.
The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065, USA. carlsonh@umich.edu
Heather A
HA
Carlson
D000818:Animals; D003198:Computer Simulation; D030562:Databases, Protein; D015195:Drug Design; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
D011506:Proteins