Synthesis of some new thiazole derivatives. antifungal activity and ultrastructure changes of some mycotoxin producing fungi.
Several new thiazoles 2-7,10-12; 2,3-diphenyl-5-(2-thienyl)imidazo[2,1-b]thiazole 8, 3,5-di-(2-thienyl)imidazo[2,1-b]thiazole 9 and 4-amino-2-imino-6-(2-thienyl)thiazolo[3,2-a] pyrimidine 13 and 6-(2-thienyl)-3H-thiazolo[3,2-a]pyrimidin-2,4-diones 14 have been synthesized. The prepared compounds were evaluated for their in-vitro antifungal activity, compared with Tioconazol fungicide. The strong antifungal activity is elicited by compounds 5 and 8. The most active compound 5 was found to induce changes in the ultrastructure of mycotoxin producing fungi (Aspergillus flavus and Aspergillus ochraceus), this was observed by both scanning and transmission electron microscopy.
Ghorab
M M
MM
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Cairo, Egypt.
El-Batal
A I
AI
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D009183:Mycotoxins / Q000096:biosynthesis*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D009183:Mycotoxins; D013844:Thiazoles