The total synthesis of alkaloids (-)-histrionicotoxin 259A, 285C and 285E.
The first total syntheses of three "unsymmetrical" (i.e. different terminal groups in the side chains) members of the histrionicotoxin family of alkaloids have been accomplished via stepwise introduction of the two side chain moieties onto a common tricyclic core.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Catherine J
CJ
Smith
Andrew B
AB
Holmes
Neil J
NJ
Press
D000470:Alkaloids / Q000138:chemical synthesis*; D000480:Alkynes / Q000737:chemistry*; D000664:Amphibian Venoms / Q000138:chemical synthesis*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*
D000470:Alkaloids; D000480:Alkynes; D000664:Amphibian Venoms; D006575:Heterocyclic Compounds, 3-Ring; C007948:histrionicotoxin