Cardiovascular effects of prostaglandin F(2 alpha) and prostaglandin E(2) in Atlantic cod (Gadus morhua).
Little is known of the cardiovascular functions of prostaglandins in non-mammalian vertebrates. There are indications that prostaglandins may have a function in haemostasis by constricting blood vessels in filament arteries in the fish gill after injury. Our aim was to examine the cardiovascular effect of the prostaglandins F(2 alpha) (PGF(2 alpha)) and E(2) (PGE(2)) with emphasis on branchial circulation. Intra-arterial injections of PGF(2 alpha) (10, 40, 160, 400 nmol kg(-1)) in cod caused a dose-dependent increase in ventral aortic blood pressure, a reduction in cardiac output, and an increase in gill vascular resistance. A contraction of filament arteries was observed with in vivo microscopy only seconds after injection. PGF(2 alpha) may therefore possibly be involved in a haemostatic vasoconstriction. In contrast, the most significant effects of PGE(2) appeared to be on the heart. PGE(2) also reduced dorsal aortic blood pressure.
Division of General Physiology, Department of Biology, University of Oslo, PO Box 1051, N-0316 Oslo, Norway. k.o.stenslokken@bio.uio.no
K-O
KO
Stensløkken
L
L
Sundin
G E
GE
Nilsson
D000818:Animals; D015237:Dinoprost / Q000494:pharmacology* / Q000502:physiology; D015232:Dinoprostone / Q000494:pharmacology* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005399:Fishes; D005880:Gills / Q000098:blood supply*; D006487:Hemostasis / Q000502:physiology; D008833:Microcirculation / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D015237:Dinoprost; D015232:Dinoprostone