Solid-phase template-directed synthesis of a [2]rotaxane using a solid-phase stopper.
The first synthesis of a rotaxane by solid phase chemistry has been achieved, using the resin bead as a 'Mega' stopper during the synthesis. One of the advantages of this methodology over traditional solution routes include the ability to use mass action to drive the chemistry, without complicating the purification process.
Department of Chemistry, University of Southampton, Southampton, UK SO17 1BJ.
José A
JA
Bravo
David
D
Orain
Mark
M
Bradley