Expression of inducible nitric oxide synthase in skin lesions of patients with american cutaneous leishmaniasis.
Cytokine-inducible (or type 2) nitric oxide synthase (iNOS) is indispensable for the resolution of Leishmania major or Leishmania donovani infections in mice. In contrast, little is known about the expression and function of iNOS in human leishmaniasis. Here, we show by immunohistological analysis of skin biopsies from Mexican patients with local (LCL) or diffuse (DCL) cutaneous leishmaniasis that the expression of iNOS was most prominent in LCL lesions with small numbers of parasites whereas lesions with a high parasite burden (LCL or DCL) contained considerably fewer iNOS-positive cells. This is the first study to suggest an antileishmanial function of iNOS in human Leishmania infections in vivo.
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany.
Muna
M
Qadoumi
Inge
I
Becker
Norbert
N
Donhauser
Martin
M
Röllinghoff
Christian
C
Bogdan
D000818:Animals; D006801:Humans; D007894:Leishmania mexicana / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000201:enzymology* / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D016774:Leishmaniasis, Diffuse Cutaneous / Q000201:enzymology* / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000096:biosynthesis* / Q000276:immunology; D052247:Nitric Oxide Synthase Type II; D012867:Skin / Q000201:enzymology / Q000473:pathology
C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II