The mechanism of effect of growth hormone on preadipocyte and adipocyte function.
Growth hormone (GH) is not only the major regulator of postnatal somatic growth but also exerts profound effects on body composition through a combination of anabolic, lipolytic and antinatriuretic actions. GH enhancement of the lipolytic activity of adipose tissue in combination with a reduction of triglyceride accumulation via inhibition of lipoprotein lipase activity appears to be the major mechanism by which GH results in a reduction of the total fat mass. Recently, much progress has been made in understanding the molecular mechanism by which GH affects cellular function. This review provides a brief discourse and summary of the mechanism of effects of GH on preadipocyte/adipocyte function. It is intended to provide a functional understanding of the mechanism of action of GH as it relates to adipogenesis and adipocyte function.
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Department of Internal Medicine, Yongdong Severance Hospital, Yonsei University College of Medicine, Dogok-dong 146-92, Kangnam-Ku, Seoul 135-270, Korea.
Lobie
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D017667:Adipocytes / Q000187:drug effects* / Q000502:physiology*; D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D011986:Receptors, Somatotropin / Q000032:analysis / Q000502:physiology; D015398:Signal Transduction; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology*
D011986:Receptors, Somatotropin; D019382:Human Growth Hormone