Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents.
The design and facile synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines is described. These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out.
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. ahmedkamal@iict.ap.nic.in
Ahmed
A
Kamal
N
N
Laxman
G
G
Ramesh
O
O
Srinivas
P
P
Ramulu
D000588:Amines / Q000737:chemistry; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000494:pharmacology*; D001569:Benzodiazepines / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D011407:Propane / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility; D018675:Toxicity Tests; D014407:Tumor Cells, Cultured
D000588:Amines; D018906:Antineoplastic Agents, Alkylating; D011758:Pyrroles; D001569:Benzodiazepines; D011407:Propane