Solvents inducing oxidation of hydroxylamines.
Hydroxylamines gradually undergo oxidation to their oximes on being dissolved in organic solvent (e.g. methanol). This phenomenon was followed by (1)H-NMR and liquid chromatography-mass spectrometry (LC-MS). The oxidation rate was estimated from the peak area observed on the mass chromatogram at the protonated molecule or fragment ion on LC-atmospheric pressure chemical ionization (APCI)-MS. The results showed that the oxidation rate of hydroxylamines depended on the solvent type.
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan. horiyama@mwu.mukogawa-u.ac.jp
Shizuyo
S
Horiyama
Kiyoko
K
Suwa
Masae
M
Yamaki
Hiromi
H
Kataoka
Toyoshi
T
Katagi
Mitsuo
M
Takayama
Takae
T
Takeuchi
D002138:Calibration; D002725:Chloroform; D002853:Chromatography, Liquid; D006898:Hydroxylamines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D012997:Solvents
D006898:Hydroxylamines; D007659:Ketones; D012997:Solvents; D002725:Chloroform