Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of 'tako-tsubo' cardiomyopathy.
The etiology of a novel cardiac syndrome 'tako-tsubo' cardiomyopathy, otherwise known as 'transient left ventricular (LV) apical ballooning' and which mimics acute myocardial infarction, is not clear; however, emotional or physical stress is known to precede the attack. Left ventriculography of rats experiencing emotional stress induced reversible LV apical ballooning, which was normalized by pretreatment with adrenoceptor blockade. Together with results of previous studies, activation of cardiac adrenoceptors in the absence of ischemia-reperfusion is proposed as the primary cause of this syndrome.
Department of Anatomy and Cell Biology, Wakayama Medical University, Japan. tueyama@wakayama-med.ac.jp
Takashi
T
Ueyama
Ken
K
Kasamatsu
Takuzo
T
Hano
Katsuhiro
K
Yamamoto
Yoshihiro
Y
Tsuruo
Ichiro
I
Nishio
D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology; D004195:Disease Models, Animal; D018476:Hypokinesia / Q000209:etiology; D009200:Myocardial Contraction; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism* / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications*; D018487:Ventricular Dysfunction, Left / Q000209:etiology*
D011941:Receptors, Adrenergic