Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats.
The effects of L-carnosine (beta-alanyl-L-histidine) on the neural activity of the renal sympathetic nerve and on DOCA-salt hypertension in rats were examined. Intravenous injection of 1 microg L-carnosine inhibited renal sympathetic nerve activity in urethane-anesthetized animals, and a diet containing 0.0001% or 0.001% L-carnosine decreased blood pressure elevation in DOCA-salt hypertensive rats. Since L-carnosine is mainly synthesized in the skeletal muscles of mammals, it is not unreasonable to postulate that L-carnosine is an endogenous factor controlling the blood pressure in a manner possibly antagonistic to the obesity-associated hypertensive effect of leptin.
Niijima
Akira
A
Niigata University School of Medicine, Asahimachidoori, Japan. anathome@med.niigata-u.ac.jp
Okui
Tomoko
T
Matsumura
Yasuo
Y
Yamano
Toshihiko
T
Tsuruoka
Nobuo
N
Kiso
Yoshinobu
Y
Nagai
Katsuya
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002336:Carnosine / Q000494:pharmacology*; D003900:Desoxycorticosterone; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D020738:Leptin / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D013997:Time Factors
D020738:Leptin; D017673:Sodium Chloride, Dietary; D003900:Desoxycorticosterone; D002336:Carnosine