[Chemical compound safety: typology of competency accreditation for assay centers and analytical laboratories].
The use of chemicals warrants many benefits on which modern society is entirely dependent. On the other hand, the lack of reliable information about the impact of the use of chemicals raises increasing concern. In order to guarantee the safety of chemicals it is mandatory to proceed to risk assessment, which in turn consists of hazard evaluation and exposure estimation. These activities are strictly dependent upon the availability of reliable data and information, produced by, e.g., test facilities, test laboratories and clinical laboratories, the specific competence of which has been properly recognised. All this applies in the pre-marketing phase as well as during the use of chemical substances. In this latter phase it is necessary to carry out an appropriate monitoring of environment, food and, in specific situations, human beings (biological monitoring). In the field of chemical safety, standards, legal instruments and operative instruments are nowadays available. These tools make it possible to assess both the quality of data and the competence of the entities involved in the production of the data themselves.
Laboratorio di Biochimica Clinica, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161 Roma. a.mendit@iss.it
Antonio
A
Menditto
Ferdinando
F
Chiodo
D000068:Accreditation / Q000331:legislation & jurisprudence / Q000592:standards*; D016573:Agrochemicals / Q000592:standards / Q000633:toxicity; D000818:Animals; D019411:Clinical Laboratory Techniques / Q000592:standards; D003132:Commerce; D004341:Drug Evaluation / Q000592:standards; D004353:Drug Evaluation, Preclinical / Q000592:standards; D005062:European Union; D017408:Guidelines as Topic; D015386:Hazardous Substances / Q000592:standards* / Q000633:toxicity; D006801:Humans; D007558:Italy; D007753:Laboratories / Q000331:legislation & jurisprudence / Q000592:standards*; D007880:Legislation, Drug; D007881:Legislation, Food; D011361:Professional Competence; D011785:Quality Assurance, Health Care / Q000331:legislation & jurisprudence / Q000458:organization & administration; D012015:Reference Standards; D012106:Research / Q000331:legislation & jurisprudence / Q000592:standards; D012107:Research Design; D018570:Risk Assessment; D012449:Safety; D014116:Toxicology / Q000331:legislation & jurisprudence / Q000592:standards*
D016573:Agrochemicals; D015386:Hazardous Substances