Evaluation of the analgesic and anti-inflammatory activities of some thiazolo[4,5-d]pyrimidines.
Some thiazolo[4,5-d]pyrimidine-7(6H)-one derivatives were evaluated in vivo for their analgesic and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid and phenylbutazone. Compounds 3b and 3h were the most active in the anti-inflammatory paw edema inhibition test. In terms of the analgesic activity (acetic acid writhing test), the most active compound was 2a followed by 31. The most active members of the series were investigated for their ED50 values and ulcerogenic potential.
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara. aebalkan@hacettepe.edu.tr
Ayla
A
Balkan
Zafer
Z
Gören
Hüsne
H
Urgun
Unsal
U
Caliş
A Nur
AN
Cakar
Pergin
P
Atilla
Tayfun
T
Uzbay
D019342:Acetic Acid; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005753:Gastric Mucosa / Q000473:pathology; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D011743:Pyrimidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology* / Q000633:toxicity
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011743:Pyrimidines; D013844:Thiazoles; D002351:Carrageenan; D019342:Acetic Acid