Anticonvulsant and sedative effects of Salvadora persica L. stem extracts.
The effect of Salvadora persica L. stem extracts on the potentiation of sodium pentobarbital activity and on generalized tonic-clonic seizure produced by pentylenetetrazol (PTZ) on the rat is reported. The extracts of Salvadora persica L. extended sleeping-time and decreased induction-time induced by sodium pentobarbital; in addition it showed protection against pentylenetetrazol-induced convulsion by increasing the latency period and diminishing the death rate.
Pharmaco-Biological Department, School of Pharmacy, University of Messina, Vill. SS. Annunziata, 98168 Messina, Italy.
M T
MT
Monforte
A
A
Trovato
A
A
Rossitto
A M
AM
Forestieri
A
A
D'Aquino
N
N
Miceli
E M
EM
Galati
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D029753:Celastraceae / Q000737:chemistry*; D004357:Drug Synergism; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology / Q000627:therapeutic use*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000009:adverse effects / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D012890:Sleep / Q000187:drug effects; D015996:Survival Rate
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D010424:Pentobarbital; D010433:Pentylenetetrazole