Common perinatal insults diminish cord blood RANTES.
We demonstrate that the cord blood RANTES concentrations are reduced in full-term newborns who were born from meconium-stained amniotic fluid as compared with full-term newborns born after normal delivery. Since RANTES inhibits immunodeficiency virus (HIV) entry into macrophages, thereby bestowing increased resistance to HIV (including protection in utero), we propose that common perinatal events might precipitate higher perinatal transmission of HIV.
Department of Pediatric Intensive Care, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Benjamin
B
Dekel
Marina
M
Rubinstein
Ram
R
Mazkeret
Danny
D
Lotan
Gideon
G
Paret
D000653:Amniotic Fluid; D018932:Chemokine CCL2 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000097:blood; D008470:Meconium; D011247:Pregnancy; D011446:Prospective Studies
D018932:Chemokine CCL2; D018946:Chemokine CCL5; D016209:Interleukin-8