Creation of an intra-atrial communication with a new Amplatzer shunt prosthesis: preliminary results in a swine model.
A nitinol shunt device was applied in six minipigs to create a precise intra-atrial shunt. This self-expanding shunt device consists of two retention disks of 2-8 mm, a 4 mm connecting waist with a 10 mm eccentric hole. It requires a 7 Fr introducer sheath. The device is attached to the delivery cable with a microscrew. Placement technique is identical to that of Amplatzer septal occluder. Balloon dilation was performed immediately and 1 month after placement. One animal died from general anesthesia before device placement. Left atrial angiography showed a patent intra-atrial shunt in 5/5 pigs immediately and 4/4 in 1- to 3-month follow up. Postmortem examination demonstrated patent shunts partially or completely neoendothelialized. The shunt device was found to be an effective and safe way to create a permanent atrial communication.
Department of Radiology, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Huafu
H
Kong
Xiaoping
X
Gu
Jack L
JL
Titus
Tae-Hoon
TH
Kim
Myra
M
Urness
Young-Min
YM
Han
Peter
P
Hessliein
John
J
Bass
Meelee
M
Chun
David W
DW
Hunter
D000497:Alloys; D000818:Animals; D006325:Heart Atria; D023421:Models, Animal; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013552:Swine; D013556:Swine, Miniature
D000497:Alloys; C013616:nitinol