Cerebral activation by the signals ascending through unmyelinated C-fibers in humans: a magnetoencephalographic study.
Cerebral processing of first pain, associated with A delta-fibers, has been studied intensively, but the cerebral processing associated with unmyelinated C-fibers, relating to second pain, remains to be investigated. This is the first study to clarify the primary cortical processing of second pain by magnetoencephalography, through the selective activation of C-fibers, by the stimulation of a tiny area of skin with a CO2 laser. In the hemisphere contralateral to the side stimulated, a one-source generator in the upper bank of the Sylvian fissure (secondary somatosensory cortex, SII) or two-source generators in SII and the hand area of the primary somatosensory cortex (SI) were the optimal configurations for the first component 1M. The onset and peak latency of the two sources in SI and SII were not significantly different. In the hemisphere ipsilateral to the stimulation, only one source was estimated in SII, and its peak latency was significantly (approximately 18 ms on average) longer than that of the SII source in the contralateral hemisphere. From our findings we suggest that parallel activation of SI and SII contralateral to the stimulation represents the first step in the cortical processing of C-fiber-related activities, probably related to second pain.
Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan. dieptuan@nips.ac.jp
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D000328:Adult; D000344:Afferent Pathways / Q000503:physiopathology; D001931:Brain Mapping; D004292:Dominance, Cerebral; D005260:Female; D006225:Hand / Q000503:physiopathology; D006801:Humans; D007834:Lasers; D015225:Magnetoencephalography; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D012867:Skin / Q000294:innervation / Q000528:radiation effects; D013003:Somatosensory Cortex / Q000503:physiopathology*