Colony-stimulating factor 1-dependent cells protect against systemic infection with Listeria monocytogenes but facilitate neuroinvasion.
By using mice genomically lacking the mononuclear phagocytic growth factor colony-stimulating factor 1 and thereby deficient in macrophage and dendritic cell populations, we show that these cells play a dual role: they constitute a major defense against systemic infection but also facilitate cerebral bacterial invasion by Listeria monocytogenes.
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Yuxuan
Y
Jin
Lone
L
Dons
Krister
K
Kristensson
Martin E
ME
Rottenberg
D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D018122:B7-1 Antigen / Q000276:immunology; D001933:Brain Stem / Q000382:microbiology; D003713:Dendritic Cells / Q000276:immunology*; D016167:Integrin alphaXbeta2 / Q000276:immunology; D008089:Listeria monocytogenes / Q000276:immunology / Q000472:pathogenicity; D008088:Listeriosis / Q000276:immunology* / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D016173:Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000276:immunology / Q000382:microbiology*; D010740:Phospholipases / Q000235:genetics / Q000276:immunology; D013154:Spleen / Q000382:microbiology; D012668:Trigeminal Ganglion / Q000382:microbiology
D000943:Antigens, Differentiation; D018122:B7-1 Antigen; D016167:Integrin alphaXbeta2; C036763:monocyte-macrophage differentiation antigen; D016173:Macrophage Colony-Stimulating Factor; D010740:Phospholipases