CD23 negative chronic lymphocytic leukemia of the tonsil: report of a case.
We present the case of atypical chronic lymphocytic leukemia presenting as a tonsillar mass in an elderly man. Histological examination of the tumor revealed diffuse submucosal infiltration by small lymphocytes. On flow cytometry, a monoclonal B lymphocytic population expressing CD5, CD19, lambda light chain, but not expressing CD10, CD23, or FMC7 activities, was observed. A diagnostic conundrum occurred with the demonstration on molecular cytogenetic analysis of the chromosomal translocation abnormality, t(11;14)(q13;q32). The diagnosis of CD23 negative chronic lymphocytic leukemia was made after further molecular studies failed to detect the bcl-1 gene rearrangement.
Ampil
Federico L
FL
Veillon
Diana M
DM
Nordberg
Mary L
ML
Nathan
Cherie Ann O
CO
Kunjumoideen
Kottapurath
K
Cotelingam
James D
JD
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology*; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology*; D017455:Receptors, IgE
D017455:Receptors, IgE