Inheriting a structural scaffold for Golgi biosynthesis.
In animal cells, the Golgi complex undergoes reversible disassembly during mitosis. The disassembly/reassembly process has been intensively studied in order to understand the mechanisms that govern organelle assembly and inheritance during cell division. A long-standing controversy in the field has been whether formation of Golgi structure is template-mediated or self-organizes from components of the endoplasmic reticulum. A recent study1 however, has demonstrated that a subset of proteins that form a putative Golgi matrix can be inherited during cell division in the absence of membrane input from the endoplasmic reticulum. The outcome of this study suggests that a templating mechanism for the formation of Golgi structure may exist. This study has important implications for understanding mechanisms that govern Golgi biogenesis.
Department of Molecular Biology and Genetics, 245 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA. saj23@cornell.edu
Stephen A
SA
Jesch
D000818:Animals; D001324:Autoantigens; D020126:Brefeldin A / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000187:drug effects / Q000378:metabolism*; D000077614:Golgi Matrix Proteins; D008565:Membrane Proteins / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology
D001324:Autoantigens; C108705:GORASP1 protein, human; D000077614:Golgi Matrix Proteins; C097741:Golgin subfamily A member 2; D008565:Membrane Proteins; D011500:Protein Synthesis Inhibitors; D020126:Brefeldin A