Transcriptional and translational control in the Mammalian unfolded protein response.
Cells monitor the physiological load placed on their endoplasmic reticulum (ER) and respond to perturbations in ER function by a process known as the unfolded protein response (UPR). In metazoans the UPR has a transcriptional component that up-regulates expression of genes that enhance the capacity of the organelle to deal with the load of client proteins and a translational component that insures tight coupling between protein biosynthesis on the cytoplasmic side and folding in the ER lumen. Together, these two components adapt the secretory apparatus to physiological load and protect cells from the consequences of protein malfolding.
Harding
Heather P
HP
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA. harding@saturn.med.nyu.edu
Calfon
Marcella
M
Urano
Fumihiko
F
Novoa
Isabel
I
Ron
David
D
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D005786:Gene Expression Regulation / Q000235:genetics; D005809:Genes, Regulator / Q000235:genetics; D006801:Humans; D008322:Mammals / Q000378:metabolism*; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis / Q000235:genetics; D017510:Protein Folding; D015398:Signal Transduction / Q000235:genetics
D018832:Molecular Chaperones