Immune surveillance and effector functions of CCR10(+) skin homing T cells.
Skin homing T cells carry memory for cutaneous Ags and play an important sentinel and effector role in host defense against pathogens that enter via the skin. CCR10 is a chemokine receptor that is preferentially expressed among blood leukocytes by a subset of memory CD4 and CD8 T cells that coexpress the skin-homing receptor cutaneous lymphocyte Ag (CLA), but not the gut-homing receptor alpha(4)beta(7). Homing and chemokine receptor coexpression studies detailed in this study suggest that the CLA(+)/CCR10(+) memory CD4 T cell population contains members that have access to both secondary lymphoid organ and skin compartments; and therefore, can act as both "central" and "effector" memory T cells. Consistent with this effector phenotype, CLA(+)/CCR10(+) memory CD4 T cells from normal donors secrete TNF and IFN-gamma but minimal IL-4 and IL-10 following in vitro stimulation. Interactions of CCR10 and its skin-associated ligand CC ligand 27 may play an important role in facilitating memory T cell entry into cutaneous sites during times of inflammation.
Hudak
Susan
S
DNAX Research, Palo Alto, CA 94304, USA.
Hagen
Michael
M
Liu
Ying
Y
Catron
Daniel
D
Oldham
Elizabeth
E
McEvoy
Leslie M
LM
Bowman
Edward P
EP
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D002465:Cell Movement; D006801:Humans; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D054447:Receptors, CCR10; D054399:Receptors, CCR6; D019707:Receptors, Chemokine / Q000502:physiology*; D012867:Skin / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; C515706:CCR10 protein, human; C106311:CCR6 protein, human; C063419:CTAGE1 protein, human; C515707:Ccr10 protein, mouse; D008562:Membrane Glycoproteins; D054447:Receptors, CCR10; D054399:Receptors, CCR6; D019707:Receptors, Chemokine; D007371:Interferon-gamma