Gap junctions in CO(2)-chemoreception and respiratory control.
Recent evidence indicates that gap junctions play a more prominent role in normal functioning of the mammalian central nervous system (CNS) than was once believed. Accumulating evidence from both neonatal and adult rodents indicates that gap junctions participate in multiple aspects of respiratory control, including central CO(2) chemoreception, respiratory rhythmogenesis, and respiratory motoneuron output. This review provides an overview of gap junction neurobiology in the mammalian CNS and presents the anatomical and electrophysiological evidence for gap junctions in CO(2) chemoreception and respiratory control.
Department of Physiology and Biophysics, State University of New York at Stony Brook, , Stony Brook, NY 11794-8661, USA. icsolomon@physiology.pnb.sunysb.edu
Irene C
IC
Solomon
Jay B
JB
Dean
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism*; D002628:Chemoreceptor Cells / Q000378:metabolism*; D017629:Gap Junctions / Q000378:metabolism*; D015656:Respiratory Mechanics / Q000502:physiology*
D002245:Carbon Dioxide