Long-term prognostic value of stress-redistribution-reinjection Tl-201 imaging in patients with severe left ventricular dysfunction and coronary artery bypass surgery.
OBJECTIVE
This study sought to evaluate the long-term prognostic significance of stress-redistribution-reinjection Tl-201 imaging in patients with severe left ventricular (LV) dysfunction and coronary artery bypass surgery.


BACKGROUND
Preoperative stress-redistribution-reinjection Tl-201 imaging detects viable but asynergic segments which show functional improvement postoperatively and is considered as a valuable noninvasive method in selection of patients with severe LV dysfunction for revascularization. The long-term prognostic value of the reinjection technique remains unclear.


METHODS
Fifty-two patients with severe LV dysfunction (mean ejection fraction (EF) 0.32+/-0.03) who underwent coronary artery bypass surgery in 1993-1994 were included in the study. Patients had follow-up 49+/-12 months. LV function was assessed by two-dimensional echocardiography. Perfusion was assessed by Tl-201 SPECT imaging and was graded on a four-point scale (0 = normal, 3 = absent uptake) using the 20 segment model. Perfusion index was derived by adding the score of all segments and dividing these by 20. Patients were divided into two groups. Group A comprised patients with seven and more dysfunctional viable myocardial segments. Group B included patients with less than seven dysfunctional but viable segments.


RESULTS
Mean EF increased from 0.32+/-0.03 to 0.46+/-0.04. Mean perfusion index did not show a significant difference as a whole during follow-up compared to the early postoperative values (0.9+/-0.4 and 1.1+/-0.4, p = NS). When adequacy of revascularization was considered, the predictive value of a positive preoperative viability test for functional improvement was 82%. Nineteen cardiac events occurred in group B patients and six in group A patients: six deaths (four from cardiac and two from noncardiac causes), 13 myocardial infarctions (MI). Multivariate Cox survival analysis identified the number of viable segments detected preoperatively (chi2 = 7.2, p = 0.002), postoperative improvement in Tl-uptake (chi2 = 6.6, p = 0.01) and functional improvement (chi2 = 5.3, p = 0.03) postoperatively as independent predictors of cardiac events. Preoperative EF and functional capacity were not associated with cardiac events in long-term prognosis.


CONCLUSIONS
These data suggest that preoperative stress-redistribution-reinjection Tl-201 imaging, specifically the number of viable segments detected preoperatively and postoperative improvement in Tl-201 uptake provide important long-term prognostic information in patients with severe LV dysfunction who had coronary artery bypass surgery.
Gürsürer
Metin
M
Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey. metgur@superonline.com
Emre
Ayşe
A
Gerçekoğlu
Hakan
H
Uslubaş
Seyfi
S
Aksoy
Mehmet
M
Ersek
Birsen
B
D016022:Case-Control Studies; D001026:Coronary Artery Bypass; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D013794:Thallium Radioisotopes; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery
D013794:Thallium Radioisotopes