Effects of sodium fluoride on total serum protein levels and transaminase activity in rats.
Transaminase activity and serum total protein level were investigated in adult rats after oral treating with sodium fluoride at three doses, 10, 20 and 30 mg/kg daily for 90 days. After 90 days, the average total serum protein level of the rats in the treatment group decreased significantly compared with that in the control [1.9 +/- 0.1 (mean +/- S.D., n = 140) vs. 3.1 +/- 0.2] mg/dl, P< 0.05. Serum transaminase activity in the treatment group increased compared with that in the control [5.3 +/- 0.4 (mean +/- S.D., n = 140) vs. 3.2 +/- 0.3] micromol/min per ml, P < 0.05.
Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Iran. dqujeq@hotmail.com
D
D
Qujeq
B
B
Laghaie
A
A
Gholipour
N
N
Solimani
S
S
Hassenzadeh
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012969:Sodium Fluoride / Q000494:pharmacology*; D000637:Transaminases / Q000097:blood*
D001798:Blood Proteins; D012969:Sodium Fluoride; D000637:Transaminases