Modulation of transmitter release at giant synapses of the auditory system.
The relay nuclei of the auditory brainstem contain some of the largest nerve terminals in the mammalian brain. Endbulb and calyceal synapses convey signals with a high degree of precision and reliability. However, recent studies reveal that these synapses possess numerous and remarkably diverse mechanisms for the modulation of transmitter release. The implication is that successful relay of signals in vivo may require the ability to fine-tune synaptic transmission.
Trussell
Laurence O
LO
Auditory Neuroscience, L-335A, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA. trussell@ohsu.edu
D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism; D015290:Second Messenger Systems; D013569:Synapses / Q000378:metabolism*; D009435:Synaptic Transmission
D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D018094:Receptors, Metabotropic Glutamate