[Low-molecular-weight autoregulatory factors in bacteria Thioalkalivibrio versutus and Thioalkalimicrobium aerophilum].
The haloalkaliphilic, lithoautotrophic, sulfur-oxidizing gram-negative bacteria Thioalkalivibrio versutus and Thioalkalimicrobium aerophilum were found to possess a special system for the autoregulation of their growth. The system includes the extracellular autoinducers of anabiosis (the d1 factor) and autolysis (the d2 factor). The principal components of the d1 factor are alkylhydroxybenzenes. The principal components of the d2 factor are free unsaturated fatty acids dominated by oleic acid isomers. Like the respective autoregulators of neutrophilic bacteria, the d1 factor of haloalkaliphilic bacteria presumably controls their growth and transition to a anabiotic state, while the d2 factor controls autolytic processes. Alkylhydroxybenzenes of both microbial and chemical origin were found to influence bacterial respiration. The low-molecular-weight osmoprotectant glycine betaine enhanced the thermostability of trypsin. This suggests that glycine betaine, like the d1 factor, serves as a molecular chaperone.
Loĭko
N G
NG
Mendeleev University of Chemical Technology, Miusskaya pl. 9, Moscow, 125190 Russia. loikonataly@mail.ru
Kozlova
A N
AN
Osipov
G A
GA
El'-Registan
G I
GI
D000222:Adaptation, Physiological; D000468:Alkalies; D001433:Bacteriolysis; D001622:Betaine / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D006358:Hot Temperature; D018832:Molecular Chaperones / Q000494:pharmacology; D013455:Sulfur / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism
D000468:Alkalies; D018832:Molecular Chaperones; D001622:Betaine; D013455:Sulfur; D014357:Trypsin