Gene therapy for superficial bladder cancer.
In this review, the basics of gene therapy and the strategies to increase the therapeutic effect of gene therapy for superficial bladder cancer are discussed. Strategies considered in detail are modification of the structure of vectors, modification of the promoters of viral vectors and the timing and route of vector administration. Although all of these modifications have shown some degree of improvement for gene transfer, the use of polyamides intravesically in conjunction with an adenoviral system shows the most promise and the greatest potential to supplement or even replace the current treatment modalities for superficial bladder cancer.
Rosser
C J
CJ
Departments of Urology and Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Box 446, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Benedict
W F
WF
Dinney
C P
CP
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D015870:Gene Expression / Q000187:drug effects; D018014:Gene Transfer Techniques; D005796:Genes; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009757:Nylons / Q000138:chemical synthesis / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D019076:Transgenes; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000628:therapy*
D009757:Nylons