Cytotoxic macrocyclic trichothecenes from the mycelia of Calcarisporium arbuscula Preuss.
A new cytotoxic macrocyclic trichothecene calcarisporin B1 (1), and two known compounds roridin H (2) and roridin J (3) were isolated from the cultured mycelia of Calcarisporium arbuscula Preuss. The structure of 1 was determined to be 8alpha-acetoxy roridin H on the basis of spectral data. The cytotoxic activities of 1-3 were evaluated in vitro.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
Neng-Jiang
NJ
Yu
Shun-Xing
SX
Guo
Hai-Yan
HY
Lu
D001203:Ascomycota; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D025282:Mycelium / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D014255:Trichothecenes / Q000737:chemistry* / Q000302:isolation & purification
D010936:Plant Extracts; D014255:Trichothecenes; C469761:calcarisporin B1