Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog.
Haemangiosarcomas of dogs were analysed by molecular genetic techniques. Regions of the tumour suppressor gene p53, including the well-known tumour hot spots (codons 175, 245, 248, 249, 273 and 282) were screened. A 24 bp deletion was detected in exon 5 of the gene.
Mayr
B
B
Institute for Animal Breeding and Genetics, Veterinary University, Veterinärplatz 1, A-1210 Vienna, Austria. Burkhard.Mayr@vu-wien.ac.at
Zwetkoff
S
S
Schaffner
G
G
Reifinger
M
M
D000818:Animals; D017931:DNA Primers; D004273:DNA, Neoplasm / Q000235:genetics*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D016158:Genes, p53 / Q000235:genetics*; D006338:Heart Neoplasms / Q000235:genetics / Q000662:veterinary; D006394:Hemangiosarcoma / Q000235:genetics / Q000662:veterinary*; D008113:Liver Neoplasms / Q000235:genetics / Q000662:veterinary; D008297:Male; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012878:Skin Neoplasms / Q000235:genetics / Q000662:veterinary; D013160:Splenic Neoplasms / Q000235:genetics / Q000662:veterinary*
D017931:DNA Primers; D004273:DNA, Neoplasm