Rational and targeted pharmacologic treatment of fibromyalgia.
Despite disappointing results when subjected to randomized clinical trials, pharmacologic agents remain an important component of FM management. Addressing the main symptoms of pain, disturbed sleep, mood disturbances, fatigue, and associated conditions is essential to improve patient functioning and enhanced quality of life. However, much work remains to design clinical trials which address the complexity of FM, while satisfying evidence based medicine paradigms.
Department of Medicine, Oregon Health and Science University, Portland VA Medical Center, Portland, OR, USA. barkhuiz@ohsu.edu
André
A
Barkhuizen
D005221:Fatigue / Q000188:drug therapy / Q000209:etiology; D005356:Fibromyalgia / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000209:etiology; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology