CD80 (B7-1) and CD86 (B7-2) genes and genetic susceptibility to coeliac disease.
The role of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in T-cell activation makes them good candidates for coeliac disease susceptibility genes. We conducted a genetic linkage study of the CD80/86 gene region in the general Finnish population and in a local subisolate. No linkage was found in either population.
Department of Tissue Typint, finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
N
N
Woolley
P
P
Holopainen
C
C
Bourgain
K
K
Mustalahti
P
P
Collin
M
M
Mäki
J
J
Partanen
D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology; D018122:B7-1 Antigen / Q000235:genetics* / Q000276:immunology; D051940:B7-2 Antigen; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology; D005387:Finland; D018703:Founder Effect; D020022:Genetic Predisposition to Disease; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology; D018895:Microsatellite Repeats
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D008562:Membrane Glycoproteins