Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.
Pitts
William J
WJ
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. william.pitts@bms.com
Guo
Junqing
J
Dhar
T G Murali
TG
Shen
Zhongqi
Z
Gu
Henry H
HH
Watterson
Scott H
SH
Bednarz
Mark S
MS
Chen
Bang Chi
BC
Barrish
Joel C
JC
Bassolino
Donna
D
Cheney
Daniel
D
Fleener
Catherine A
CA
Rouleau
Katherine A
KA
Hollenbaugh
Diane L
DL
Iwanowicz
Edwin J
EJ
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D014227:Triazines; D007168:IMP Dehydrogenase