Functional study on nitroxidergic nerve in isolated dog pulmonary arteries and veins.
In dog pulmonary arterial and venous strips without endothelium under treatment with prazosin, nicotine induced relaxation that was abolished by N(G)-nitro-L-arginine, hexamethonium and methylene blue. L-Arginine antagonized the N(G)-nitro-L-arginine action. Neurogenic relaxations tended to be more evident in the vein. Nitric oxide (NO)-induced relaxations were greater in the veins than in the arteries. Concentrations of NO to induce the same magnitude of relaxation as that to nicotine were higher in the arteries. In conclusion, dog pulmonary arteries and veins are innervated by nitroxidergic (nitrergic) nerves, and NO is released by nerve stimulation with nicotine in a larger amount in the artery than the vein.
Department of Pharmacology, Shiga University of Medical Science, Seta, Ohtsu, Japan.
Kazuhide
K
Ayajiki
Tomio
T
Okamura
Kumiko
K
Noda
Noboru
N
Toda
D000818:Animals; D004285:Dogs; D018738:Hexamethonium / Q000494:pharmacology; D066298:In Vitro Techniques; D008751:Methylene Blue / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D019335:Nitroarginine / Q000494:pharmacology; D009589:Nitrogen Oxides / Q000378:metabolism*; D011651:Pulmonary Artery / Q000294:innervation* / Q000502:physiology; D011667:Pulmonary Veins / Q000294:innervation* / Q000502:physiology
D009589:Nitrogen Oxides; D019335:Nitroarginine; D018738:Hexamethonium; D009538:Nicotine; D008751:Methylene Blue