Amyloid beta-peptide induces cholinergic dysfunction and cognitive deficits: a minireview.
Amyloid beta-peptide (Abeta) plays a critical role in the development of Alzheimer's disease (AD). Much progress has been made in understanding this age-related neurodegenerative disorder, thus an insight into the cellular actions of Abeta and resulting functional consequences may contribute to preventive and therapeutic approaches for AD. In this review, recent evidence of Abeta-induced brain dysfunction, particularly of cholinergic impairment and memory deficits is summarized. Moreover, proposed mechanisms for Abeta-induced neurotoxicity such as oxidative stress, ion-channel formation, and Abeta-receptor interaction are discussed.
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Manh Hung
MH
Tran
Kiyofumi
K
Yamada
Toshitaka
T
Nabeshima
D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003072:Cognition Disorders / Q000139:chemically induced*; D005544:Forecasting; D006801:Humans; D007700:Kinetics; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D017434:Protein Structure, Tertiary; D011950:Receptors, Cholinergic / Q000187:drug effects
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D011950:Receptors, Cholinergic; D002795:Choline O-Acetyltransferase