Increased post-exercise facilitation of motor evoked potentials in multiple sclerosis.
OBJECTIVE
To study post-exercise facilitation following a non-fatigue exercise in a homogenous group of multiple sclerosis (MS) patients with complaints of muscle fatigue.


METHODS
In 15 MS patients and matched controls motor evoked potentials (MEP) were recorded from the biceps brachii muscle at time delays of 0.5-30s after an isometric contraction with a torque of 50% of maximal voluntary contraction (MVC) maintained for 2-6s. In addition, MEP was recorded after isometric torque of 25, 50, and 100% of MVC maintained for 6s.


RESULTS
Isometric non-fatigue contraction induced significant post-exercise increase in MEP amplitude in MS patients compared with controls being most pronounced after a contraction for 6s. The post-exercise increase in MEP lasted for longer than 30s in MS patients.


CONCLUSIONS
Post-exercise increase of MEP amplitude following a non-fatigue exercise was significant in MS patients with complaints of muscle fatigue compared with healthy subjects.
Nielsen
Jørgen Feldbaek
JF
Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, Aarhus, Denmark. jfn@akhphd.au.dk
Nørgaard
Pernille
P
D000328:Adult; D019054:Evoked Potentials, Motor; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D013997:Time Factors; D019415:Torque