Two pedigrees of hereditary prostate cancer.
We encountered two pedigrees of hereditary prostate cancer. In one family, the father and his two sons had prostate cancer, and in the other family, three brothers developed prostate cancer. The mean age of these six individuals at the first examination was 65.3 years. Two individuals had stage B disease; three individuals, stage D disease; and one individual, disease of unknown stage. Histopathologically, two, one, and three individuals had well-, moderately, and poorly differentiated adenocarcinoma, respectively. As of September 28,2000, five of the six individuals were still alive. In a search of the literature, these were found to be the seventh and eighth pedigrees in Japan that met the criteria of hereditary prostate cancer proposed by Carter and colleagues in 1993.
Department of Urology, Gunma University School of Medicine, Maebashi, Japan. y-sekine@sannet.ne.jp
Yoshitaka
Y
Sekine
Kazunari
K
Ohki
Kohei
K
Okamoto
Hikaru
H
Tomita
Masashi
M
Nomura
Nobuaki
N
Ohtake
Seiji
S
Nakata
Yasushige
Y
Matsuo
Hisanori
H
Yajima
Tohru
T
Mashimo
Tadatoshi
T
Shinozaki
Yasuo
Y
Nakazawa
Kenzo
K
Uchida
Kyoichiro
K
Kamiya
Hidetoshi
H
Yamanaka
Keiji
K
Suzuki
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology
D017430:Prostate-Specific Antigen