MPO-ANCA-positive slowly progressive glomerulonephritis with focal tuft necrosis and crescents.
A 37-year-old woman had been found to have proteinuria in October 1996. About 8 months later, the first renal biopsy was performed, revealing focal segmental necrotizing and crescentic glomerulonephritis. At that time, serum creatinine was 1.0 mg/dl and urinary protein 3+. In October 1999, laboratory tests revealed positivity for MPO-ANCA and a serum creatinine level of 1.42 mg/dl, anemia and proteinuria of 2+. A second renal biopsy showed almost the same histological findings. Accordingly, a diagnosis of MPO-ANCA positive glomerulonephritis was made. This patient was thought to be a rare case of MPO-ANCA-positive slowly progressive glomerulonephritis presenting focal segmental tuft necrosis and crescents.
Department of Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa.
Togo
T
Aoyama
Takeshi
T
Shimizu
Takatoshi
T
Matsuo
Hisato
H
Sakamoto
Kouju
K
Kamata
Masaaki
M
Higashihara
Hiroshi
H
Tsuji
Hidekazu
H
Shigematsu
Yutaka
Y
Kobayashi
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005455:Fluorescent Antibody Technique; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007678:Kidney Glomerulus / Q000648:ultrastructure; D009195:Peroxidase / Q000097:blood*
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase