Efficient enantioselective additions of terminal alkynes and aldehydes under operationally convenient conditions.
[reaction: see text] The enantioselective addition reaction of terminal acetylenes and aldehydes mediated by Zn(OTf)2 and N-methyl ephedrine can be conducted with reagent grade solvent containing 84-1000 ppm H2O. The products can be isolated in high yield and useful enantioselectivities (up to 99% ee).
Laboratorium für Organische Chemie, ETH-Hönggerberg HCI H335, CH-8093 Zürich, Switzerland.
Dean
D
Boyall
Doug E
DE
Frantz
Erick M
EM
Carreira