Inhibitory effects of echinoisoflavanone and sophoraisoflavanone D in Sophora chrysophylla SEEM on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro.
We present the results of an in vitro investigation of the inhibitory effects of echinoisoflavanone and sophoraisoflavanone D isolated from Sophora chrysophylla SEEM on copper-induced protein oxidative modification of mouse brain homogenate in vitro. They inhibited copper-induced protein oxidative modification. The order of inhibitory effects of these isoflavanones and mannitol as a hydroxyl radical scavenger was sophoraisoflavanone D > mannitol > echinoisoflavanone. The results suggest that these natural products may be of use in cases where oxidative stress is present.
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, 2-11-1 Wakaba, Kumatori, Sen-nan, Osaka 590-0482, Japan.
Shizuo
S
Toda
Yoshiaki
Y
Shirataki
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003300:Copper / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D029909:Sophora / Q000737:chemistry*; D014020:Tissue Extracts / Q000378:metabolism
D016166:Free Radical Scavengers; D007529:Isoflavones; D014020:Tissue Extracts; C441782:echinoisoflavanone; C441783:sophoraisoflavanone D; D017665:Hydroxyl Radical; D008353:Mannitol; D003300:Copper