[Intravitreal injection of doxorobicin and dexamethason in treatment of proliferative vitreoretinopathy].
OBJECTIVE
To investigate the inhibitory effect of intravitreal injection of doxorubicin and dexamethason on proliferative vitreoretinopathy (PVR).


METHODS
Forty-two eyes with retinal detachment complicated with proliferative vitreoretinopathy underwent surgery and intravitreal injection of doxorubicin and dexamethason and followed up for 3 approximately 5 months. The curative effect was compared with that of pure surgery on 30 eyes with retinal detachment complicated with PVR. Relevant hemodynamic changes of central retinal artery (CRA) and central retinal vein (CRV) were also evaluated.


RESULTS
Retinal reattachment was found in most eyes in both groups postoperatively. The worsening rate of epiretinal membrane and subretinal membrane was 7.1% and 26.7% in the surgery plus injection group and pure surgery group respectively (P < 0.05). The maximum average systole flow rate of CRA and CRV were 6.3 cm/s +/- 2.5 cm/s and 4.8 cm/s +/- 1.4 cm/s, 33.7% and 16.7% than normal value respectively.


CONCLUSIONS
Intravitreal injection of doxorubicin and dexamethason is effective against proliferative vitreoretinopathy.
Department of Ophthalmology, Tongji Hospital Affiliated to Tongji University, Shanghai 20006, China.
Ao
A
Rong
Jingwen
J
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D016896:Treatment Outcome; D014785:Vision, Ocular; D014822:Vitreous Body
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin