Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer.
Interleukin 10 (IL-10) is an immunosuppressive cytokine produced by T-lymphocytes, and is a regulatory molecule for angiogenesis in various cancers. We examined IL-10 and vascular endothelial growth factor (VEGF) gene expression in 45 esophageal cancer patients who underwent surgical resection. Thirty-seven (82.2%) of the 45 esophageal cancers revealed IL-10 gene expression. VEGF121, VEGF165 and VEGF189 isoforms were detected in 93.3% (42/45), 55.6% (25/45) and 26.7% (12/45) of cases, respectively. IL-10 gene expression was significantly correlated with VEGF121 gene expression (P=0.0039, Fisher's test). The results suggested that IL-10 stimulates angiogenic factor gene expression.
Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa 259-1193, Japan.
Junko
J
Nagata
Hiroshi
H
Kijima
Hiroyuki
H
Hatanaka
Tetsuji
T
Tokunaga
Atsushi
A
Takagi
Tetsuya
T
Mine
Hitoshi
H
Yamazaki
Masato
M
Nakamura
Yoshito
Y
Ueyama
D017398:Alternative Splicing; D043925:Angiogenesis Inducing Agents / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D042461:Vascular Endothelial Growth Factor A
D043925:Angiogenesis Inducing Agents; D009363:Neoplasm Proteins; D020033:Protein Isoforms; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10