A clinical index predicting mortality with Pseudomonas aeruginosa bacteraemia.
The aim of this study was to define risk factors associated with mortality in Pseudomonas aeruginosa bactaeremia and to combine them in a clinical index predicting the risk of death. The study investigated 125 consecutive episodes of P. aeruginosa bacteraemia at this hospital. Crude mortality was 34%, corresponding to 43 patients who died, with 67% of deaths, directly attributable to bacteraemia. A regression logistic model identified five variables that were independently and significantly associated with an increased risk of death: 1) hospitalisation in the intensive care unit; 2) coagulopathy; 3) septic shock; 4) age > or = 65 years; and 5) the clinical condition of the patient. These variables were as recorded at the time that the first positive blood culture was obtained. The sensitivity and specificity of a prediction of death based on the model were 84% and 85%, respectively. An index score, calculated from these variables, divided patients into three groups with increasing likelihood of mortality resulting from P. aeruginosa bacteraemia.
Aliaga
Luis
L
Infectious Diseases Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Mediavilla
Juan Diego
JD
Infectious Diseases Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Cobo
Fernando
F
Infectious Diseases Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011552:Pseudomonas Infections / Q000401:mortality*; D011550:Pseudomonas aeruginosa; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000401:mortality; D016019:Survival Analysis