Intraadministration associations: conditional hyperalgesia elicited by morphine onset cues.
There is evidence that exteroceptive cues associated with drug administration elicit conditional compensatory responding (e.g., hyperalgesia in organisms with a history of morphine administration). Recently it has become apparent that, within each administration, interoceptive early-drug onset cues (DOCs) may become associated with the later, larger drug effect (intraadministration associations). The present experiments evaluated DOC-elicited conditional hyperalgesia in rats intravenously infused with morphine. The results indicated that DOC-elicited hyperalgesia contributes to tolerance to the analgesic effect of morphine, and such DOC-elicited hyperalgesia is an associative phenomenon, rather than a sensitized response to the opiate. The findings suggest that associative analyses of tolerance should acknowledge the conditional responding elicited by DOCs, and extinction-based addiction treatments should incorporate extinction of DOC-elicited conditional responding.
Department of Psychology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Marta
M
Sokolowska
Shepard
S
Siegel
Joseph A
JA
Kim
D000701:Analgesics, Opioid / Q000009:adverse effects*; D000818:Animals; D001244:Association; D003213:Conditioning, Psychological; D003463:Cues; D004361:Drug Tolerance; D006930:Hyperalgesia / Q000139:chemically induced*; D007275:Injections, Intravenous; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000701:Analgesics, Opioid; D009020:Morphine