Lineage conversion from acute lymphoblastic leukemia to acute myeloid leukemia on rearrangement of the IgH gene in a patient with Down syndrome.
A patient with Down syndrome (DS) at the time of diagnosis of acute lymphoblastic leukemia (ALL) had a relapse with acute myeloid leukemia (AML) after 4 years of complete remission. Although the diagnosis was AML, the leukemic blasts at relapse showed an immunoglobulin H rearrangement that turned out to be identical to that of the initial ALL blasts. It is thought that the leukemic precursor cells of this patient had the potential to differentiate into both lymphoid and myeloid lineages. This case is important for investigating target cells for leukemogenesis in DS.
Second Department of Internal Medicine, Nagoya City University Medical School, Japan. tsuboi@pf6.so-net.ne.jp
Kazuya
K
Tsuboi
Makoto
M
Yazaki
Hiroshi
H
Miwa
Shinsuke
S
Iida
Shogo
S
Banno
Atsushi
A
Wakita
Masakazu
M
Nitta
Ryuzo
R
Ueda
D000328:Adult; D015139:Blotting, Southern; D002471:Cell Transformation, Neoplastic; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement / Q000502:physiology; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D012008:Recurrence; D020133:Reverse Transcriptase Polymerase Chain Reaction