A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes.
The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.
Division of Bioorganic Chemistry, Bioorganic Chemistry Program, Department of Molecular Biology & Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8103, St. Louis, MO 63110, USA.
Paul H
PH
Schlesinger
Riccardo
R
Ferdani
Robert
R
Pajewski
Jolanta
J
Pajewska
George W
GW
Gokel
D018118:Chloride Channels / Q000737:chemistry* / Q000378:metabolism*; D006016:Glycolates / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry* / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D009842:Oligopeptides / Q000032:analysis / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry
D018118:Chloride Channels; D006016:Glycolates; D006838:Hydrocarbons; D008081:Liposomes; D009842:Oligopeptides; D010743:Phospholipids; C031149:glycolic acid