A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol, and 2% aqueous chlorhexidine.
ChloraPrep (2% chlorhexidine gluconate + 70% isopropyl alcohol [CHG + IPA] in a 3.0-mL applicator) is a recently approved antiseptic for preoperative skin preparation. This controlled open-label trial assessed the immediate and persistent antimicrobial efficacy and safety of CHG + IPA compared with 70% IPA or a 2% CHG aqueous solution alone. Each antiseptic significantly reduced abdominal and inguinal microbial counts from baseline at 10 minutes, 6 hours, and 24 hours (P =.0001). CHG + IPA provided significantly more persistent antimicrobial activity on abdominal sites than IPA (P =.003) or CHG (P =.028) at 24 hours. No skin irritations were reported for any of the three antiseptics.
Mediflex Hospital Products Inc., 8717 West 110th Street, Suite 750, Overland Park, KS 66210, USA.
John S
JS
Hibbard
Gayle K
GK
Mulberry
Ann R
AR
Brady
D019840:2-Propanol / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003428:Cross Infection / Q000517:prevention & control; D003879:Dermatologic Agents / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D008875:Middle Aged; D011300:Preoperative Care; D012867:Skin / Q000382:microbiology*; D018709:Statistics, Nonparametric
D000891:Anti-Infective Agents, Local; D003879:Dermatologic Agents; D004338:Drug Combinations; C010882:chlorhexidine gluconate; D019840:2-Propanol; D002710:Chlorhexidine