Trichosetin, a novel tetramic acid antibiotic produced in dual culture of Trichoderma harzianum and Catharanthus roseus Callus.
The dual culture of Trichoderma harzianum and Catharanthus roseus callus produced an antimicrobial compound with a remarkable activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Structural elucidation revealed that this compound, which we have named trichosetin, is a novel tetramic acid (2,4-pyrrolidinedione) antibiotic and a homolog of the fungal metabolite equisetin. This compound however, was not produced in the individual culture of T. harzianum or C. roseus callus.
Department of Biotechnology, Graduate School of Engineering, Osaka University, Japan.
Eufrocinio C
EC
Marfori
Shin'ichiro
S
Kajiyama
Ei-ichiro
E
Fukusaki
Akio
A
Kobayashi
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D030008:Catharanthus / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009172:Mycology / Q000379:methods; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013764:Tetrahydronaphthalenes; D014242:Trichoderma / Q000502:physiology*; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C465303:trichosetin; C024509:equisetin