Partial liquid ventilation with low dose of perflubron and a low stretch ventilation strategy improves oxygenation in a rabbit model of surfactant depletion.
To demonstrate the efficacy of partial liquid ventilation (PLV) with a low dose of perflubron (PFB), severe lung injury model followed surfactant-depleted rabbits underwent PLV with either moderate tidal volume (V(T)) and high positive end-expiratory pressure (PEEP) or high V(T) and low PEEP. PLV with low-dose PFB was effective in alleviating hypoxia in a severe lung injury model if adequate PEEP was applied. We concluded that the addition of a low dose of PFB might be beneficial to a low stretch ventilation strategy, which allows a less aggressive approach to achieve adequate oxygenation with a possible reduction in further lung injury.
Division of Neonatology, Nagano Children's Hospital, Japan. tnakamura@naganoch.gr.jp
Tomohiko
T
Nakamura
Masanori
M
Tamura
D000818:Animals; D004195:Disease Models, Animal; D005466:Fluorocarbons / Q000627:therapeutic use*; D006801:Humans; D006842:Hydrocarbons, Brominated; D007231:Infant, Newborn; D021061:Liquid Ventilation / Q000379:methods*; D010092:Oximetry; D011175:Positive-Pressure Respiration; D011663:Pulmonary Surfactants / Q000378:metabolism*; D011817:Rabbits; D011897:Random Allocation; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D013990:Tidal Volume
D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D011663:Pulmonary Surfactants; C003072:perflubron