Theory of sequence effects on DNA translocation through proteins and nanopores.
A general formula for the sequence effects on the average translocation time of a polymer passing through a narrow hole under a chemical potential gradient is provided. The utility of the general expression is illustrated by considering the diblock sequence of a polymer with two kinds of monomers. The experimental conditions required for sufficient discrimination of various sequences are addressed.
Muthukumar
Murugappan
M
Polymer Science and Engineering, University of Massachusetts, Amherst, MA, USA. muthu@rati.pse.umass.edu
D004247:DNA / Q000737:chemistry*; D008432:Mathematical Computing; D011506:Proteins / Q000737:chemistry*
D011506:Proteins; D004247:DNA