Biguanide-atovaquone synergy against Plasmodium falciparum in vitro.
The synergistic potential of a range of biguanides, their triazine metabolites, tetracyclines, and pyrimethamine in combination with atovaquone has been assessed. All five biguanides tested interacted synergistically with atovaquone against Plasmodium falciparum in vitro. All of the other compounds tested were either additive or antagonistic.
Jones
K
K
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L35QA, United Kingdom.
Ward
S A
SA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology*; D053626:Atovaquone; D001645:Biguanides / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D009285:Naphthoquinones / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000494:pharmacology; D013754:Tetracyclines; D014227:Triazines / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D001645:Biguanides; D004338:Drug Combinations; D009285:Naphthoquinones; D013754:Tetracyclines; D014227:Triazines; D053626:Atovaquone; D011739:Pyrimethamine