Insulin-like growth factors and risk of benign prostatic hyperplasia.
BACKGROUND
Insulin-like growth factors (IGFs) have potent growth mitogenic and anti-apoptotic effects on prostate tissue, whereas IGF binding proteins (IGFBPs) inhibit growth of prostatic tissue. The IGF axis has been implicated in prostate cancer risk, but its role in benign prostatic hyperplasia (BPH) is unclear.


METHODS
Plasma levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3 were determined from the fasting bloods of 206 BPH cases admitted for treatment and 306 randomly selected population controls in Shanghai, China.


RESULTS
Relative to the lowest tertile, men in the highest tertile of IGF-I levels had a significantly elevated risk of BPH (odds ratio [OR] = 2.80, 95% confidence interval [95% CI] = 1.60-4.92; P(trend) < 0.001). Results for IGF-I were more pronounced after adjustment for serum androgens. In contrast, men in the highest IGFBP-3 tertile had a significantly reduced risk (OR = 0.40; 95% CI = 0.23-0.69; P(trend) < 0.001). No associations of BPH with IGF-II and IGFBP-1 were observed.


CONCLUSIONS
As has been previously observed for prostate cancer, we found that IGF-I and IGFBP-3 are associated with BPH risk in China. Further investigation is needed to elucidate the role of the IGF axis in BPH etiology.
Chokkalingam
Anand P
AP
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. chokkala@mail.nih.gov
Gao
Yu-Tang
YT
Deng
Jie
J
Stanczyk
Frank Z
FZ
Sesterhenn
Isabell A
IA
Mostofi
F K
FK
Fraumeni
Joseph F
JF
Hsing
Ann W
AW
D000368:Aged; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000453:epidemiology / Q000209:etiology*; D011897:Random Allocation; D012306:Risk
D015415:Biomarkers; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I