FHA: a signal transduction domain with diverse specificity and function.
The structure of the FHA domain of the Chfr mitotic checkpoint protein described in this issue of Structure represents one of only a few known structures of this newly discovered phosphoprotein binding domain with diverse function and specificity.
Tsai
Ming Daw
MD
Department of Chemistry, The Ohio State University, Columbus 43210, USA.
D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009363:Neoplasm Proteins; D010750:Phosphoproteins / Q000378:metabolism; D000075223:Poly-ADP-Ribose Binding Proteins; D011487:Protein Conformation; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases
D018797:Cell Cycle Proteins; D009363:Neoplasm Proteins; D010750:Phosphoproteins; D000075223:Poly-ADP-Ribose Binding Proteins; C412002:CHFR protein, human; D044767:Ubiquitin-Protein Ligases