Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure.
The aim of this study was first, to evaluate the effects of continuous hemodiafiltration (CHDF) alone or combined with CHDF and polymyxin-B immobilized fiber (PMX) on survival rates of patients with sepsis and acute renal failure, and second, to evaluate the changes in plasma levels of inflammatory cytokines before and after treatment with CHDF and PMX and CHDF alone in these patients. Forty-eight patients with septic shock and acute renal failure were enrolled in this study. The survival rate of all patients at 28 days was 25% for those with CHDF and 75% for those with PMX and CHDF treatment. Combination treatment produced a significant reduction of plasma levels of endotoxin and interleukin-6 compared to the basal values and to the treatment with CHDF alone. From these data, it is suggested that the combined therapy with PMX and CHDF is effective in improvement of survival rate of patients with septic shock and acute renal failure.
Department of Nephrology and Kidney Disease Center, Saitama Medical College, Saitama, Japan. iromichi@saitama-med.ac.jp
Hiromichi
H
Suzuki
Hironori
H
Nemoto
Hidetomo
H
Nakamoto
Hirokazu
H
Okada
Soichi
S
Sugahara
Yoshihiko
Y
Kanno
Kenshi
K
Moriwaki
D058186:Acute Kidney Injury / Q000401:mortality / Q000628:therapy*; D000368:Aged; D004731:Endotoxins / Q000097:blood; D005260:Female; D017583:Hemodiafiltration / Q000379:methods* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000627:therapeutic use*; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000401:mortality / Q000628:therapy*
D004731:Endotoxins; D011112:Polymyxin B