Ion chromatographic determination of trace hydroxylamine in waste streams generated by a pharmaceutical reaction process.
Hydroxylamine is a key raw material used in a synthetic drug process at Pharmacia. Since hydroxylamine is harmful to microorganisms, concentrations above 5 ppm could interfere with the biological sewage plant performance. This necessitated the development of a sensitive analytical method for detecting low levels of hydroxylamine in the waste streams generated from the pharmaceutical process. The present report describes a cation-exchange chromatographic method coupled with pulsed amperometric detection at a gold electrode for trace analysis of hydroxylamine. This method was evaluated by generating data on the parameters of specificity, precision, linearity, recovery and sensitivity.
Pharmacia Corporation, Skokie, IL 60077, USA.
Peter N
PN
Fernando
Ignatius N
IN
Egwu
Mumtaz S
MS
Hussain
D002411:Cation Exchange Resins; D002852:Chromatography, Ion Exchange / Q000379:methods*; D004345:Drug Industry; D019811:Hydroxylamine / Q000032:analysis*; D007220:Industrial Waste; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000032:analysis*
D002411:Cation Exchange Resins; D007220:Industrial Waste; D014874:Water Pollutants, Chemical; D019811:Hydroxylamine