[Relation between the serum tissue polypeptide specific antigen level and the biological demeanour of lung cancer].
OBJECTIVE
To investigate the relation between the serum tissue polypeptide specific antigen and the biological demeanour of lung cancer and analyze its clinical meaning for diagnosis of lung cancer.


METHODS
By ELISA, the serum TPS was tested in 69 patients with lung cancer, 20 patients with pulmonary tuberculosis or pneumonia.


RESULTS
The serum TPS in patients with lung cancer (273 +/- 172) U/L was significantly higher than the with benign lesions [(115 +/- 97) U/L, P < 0.001]. TPS level was related to clinical TNM stages and histological grades. It was significantly higher with TNM III, IV stages than that with I and II stages (P < 0.001). The contents of TPS in sera of 52 patients with lymphoid node metastasis were apparently higher than those of 17 cases without metastasis (P < 0.01). And it was higher in patients with small-cell lung cancer (346 +/- 163) U/L than that with non-small-cell lung cancer [(248 +/- 165) U/L, P < 0.05]. 16 post-chemotherapy patients show a lower TPS [(178 +/- 80) U/L] than pre-chemotherapy [(252 +/- 166) U/L, P < 0.05]. TPS was related with CEA (P < 0.01), NSE (P < 0.05) and TPA (P < 0.05), but not with CYFRA 21 - 1 (P > 0.05).


CONCLUSIONS
Serum TPS level is closely connected with TNM stages, histological grades and lymphoid node metastases and may serve as a novel marker for diagnosis of lung cancer.
Chen
Mingsheng
M
Department of Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Liu
Jianxin
J
Yu
Wenbin
W
Lu
Baobi
B
Dai
Yanli
Y
D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019396:Tissue Polypeptide Antigen / Q000097:blood*
D019396:Tissue Polypeptide Antigen