Oxiracetam prevented the scopolamine but not the diazepam induced memory deficits in mice.
In mice, the elevated plus-maze paradigm was used to investigate the effect of scopolamine hydrobromide and diazepam and their interaction with oxiracetam on the retrieval of spatial memory trace. This paradigm measures (using the transfer latency) an animal's capacity to escape from the open arm to the enclosed one. The retention session followed 24 h after the acquisition one. Experiment 1: Scopolamine (0.25 and 0.5 mg/kg) and diazepam (0.5 and 1.0 mg/kg) given 30 min before the retention session significantly prolonged the transfer latency as compared with the saline treated mice and those given the lowest dose of scopolamine (0.125 mg/kg) and diazepam (0.25 mg/kg). Experiment 2: Oxiracetam administered at doses of 3, 10 and 30 mg/kg immediately after the acquisition session prevented the scopolamine induced prolongation of the transfer latency. Thus, oxiracetam forestalled the impairment of retrieval of memory trace: the animals were able to remember the spatial configuration of the plus-maze. On the contrary, oxiracetam was not effective in the diazepam treated mice. We suggest that beneficial effect of oxiracetam might be confounded or blocked by the anxiolytic effect of diazepam.
Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4, Czech Republic.
Zdenek
Z
Hlinák
Ivan
I
Krejcí
D000818:Animals; D001007:Anxiety / Q000523:psychology; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology*; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014163:Transfer, Psychology / Q000187:drug effects
D018757:GABA Modulators; D018727:Muscarinic Antagonists; D018697:Nootropic Agents; D011759:Pyrrolidines; D012601:Scopolamine; C040619:oxiracetam; D003975:Diazepam