Kinetic study of citric acid influence on calcium phosphate bone cements as water-reducing agent.
Most of the research performed on calcium phosphate bone cements (CPBCs) has dealt with the improvement of bone cement formulations for new, demanding bone-filling applications. In particular, the development of injectable bone cements is of real interest for the biomedical community. The aim of this work was to study the effect of citric acid on the injectability and the setting properties of alpha-tricalcium phosphate-based cements. A comparative kinetic study was performed on cements with and without citric acid relating the hardening curves and the hydration rates using a mathematical approach. Citric acid behaved as a fluidificant during the first stages of the cement mixing. The dissolution-precipitation reactions of the alpha-tricalcium phosphate were retarded with the addition of citric acid and the compressive strength at saturation increased. In conclusion, citric acid can behave as a water-reducing admixture.
Sarda
S
S
Research Centre in Biomedical Engineering, Biomaterials Division, Department of Materials Science and Metallurgy, Technological University of Catalonia (UPC), Avda. Diagonal 647, E-08028 Barcelona, Spain.
Fernández
E
E
Nilsson
M
M
Balcells
M
M
Planell
J A
JA
D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D019343:Citric Acid / Q000737:chemistry*; D019245:Compressive Strength; D006863:Hydrogen-Ion Concentration; D007267:Injections; D008433:Mathematics; D008855:Microscopy, Electron, Scanning; D013223:Statistics as Topic; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
D001843:Bone Cements; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D014867:Water; D019343:Citric Acid; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous