Novel HLA-A locus alleles including A*01012, A*0306, A*0308, A*2616, A*2617, A*3009, A*3206, A*3403, A*3602 and A*6604.
This paper describes 10 novel HLA-A alleles that have been characterized by DNA sequencing. Seven alleles, A*0308, A*2616, A*3009, A*3206, A*3403, A*3602 and A*6604 carry motifs observed in other HLA-A alleles, suggesting that gene conversion has created this diversity. The remaining three alleles, A*01012, A*0306 and A*2617, contain polymorphisms not previously found in any "classical" class I allele. All alleles were identified due to unexpected probe hybridization patterns during routine SSOP typing. Exons 2 and 3 of each allele were subsequently characterized by DNA sequencing.
Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA.
D
D
Bradshaw
C P
CP
Gans
P
P
Jones
G
G
Rizzuto
N
N
Steiner
W
W
Mitton
J
J
Ng
R
R
Koester
R J
RJ
Hartzman
C K
CK
Hurley
D000483:Alleles; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
D015234:HLA-A Antigens