Optimal values of flow velocity on transcranial Doppler in grading middle cerebral artery stenosis in comparison with magnetic resonance angiography.
OBJECTIVE
To investigate the optimal values of flow velocity on transcranial Doppler (TCD) in grading the severity of middle cerebral artery (MCA) stenosis in comparison with magnetic resonance angiography (MRA).


METHODS
Both TCD and MRA examinations were performed on 148 asymptomatic patients. The peak flow velocities of each MCA were recorded. Severity of MCA stenosis on MRA was classified as normal-mild (< 50% lumen diameter reduction), moderate (50%-75%), and severe-void (> 75% and void of flow signal).


RESULTS
Among 296 MCAs evaluated, normal-mild stenosis was found in 75 (25%), moderate stenosis in 112 (38%), and severe stenosis in 109 (37%). The mean of systolic velocity (Vs) of MCA differed significantly among these three groups: mean Vs = 121.83 +/- 22.52 cm/s in the normal-mild group; 155.96 +/- 21.62 cm/s for the moderate group; and 199.39 +/- 43.86 cm/s for the severe group (P < .001). The optimal cutoff velocity for detection of MCA (> 50%) stenosis was found at Vs > 140 cm/s on TCD (area under the ROC curve is 0.87, P < 0.001). The best cutoff points for grading severity of on TCD were 140 cm/s and 180 cm/s.


CONCLUSIONS
TCD enables grading of the severity of MCA stenosis according to the flow velocity. This method provides a noninvasive and reliable method for grading MCA stenosis and allows longitudinal monitoring of the relationship between clinical outcome and hemodynamic change.
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China.
Shan
S
Gao
Wynnie W M
WW
Lam
Yu Leung
YL
Chan
Jun Yan
JY
Liu
Ka Sing
KS
Wong
D001783:Blood Flow Velocity; D002539:Cerebral Arterial Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D016009:Chi-Square Distribution; D006801:Humans; D018810:Magnetic Resonance Angiography; D020768:Middle Cerebral Artery; D012372:ROC Curve; D017585:Ultrasonography, Doppler, Transcranial