Disseminated pagetoid reticulosis (Ketron-Goodman disease): six-year follow-up.
Pagetoid reticulosis consists of 2 types: Woringer-Kolopp and Ketron-Goodman disease (K-G). Compared with the former, K-G may have disseminated lesions and a guarded prognosis. We encountered a case of K-G in a 67-year-old man with disseminated plaques on the neck, the trunk, and both extremities. Histologic specimens demonstrated medium- to large-sized, atypical cells infiltrating in the lower epidermis. The phenotype (CD3(+), CD4(-), CD8(-), CD45RO(-), CD45RA(+)) and ultrastructural findings suggest that these cells were immature T cells. Although PUVA was initially effective, new plaques in which atypical cells are still present histologically, have appeared through a 6-year follow-up. Literature review revealed the high rate of recurrence. These findings suggest that K-G is an epidermotropic or immature T-cell variant of mycosis fungoides. In patients with K-G, therefore, long-term observation is necessary: Disappearance of cutaneous lesions may not mean cure.
Department of Dermatology, Showa University School of Medicine, Tokyo, Japan. tokio@med.showa-u.ac.jp
Tokio
T
Nakada
Hirohiko
H
Sueki
Masafumi
M
Iijima
D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local; D011701:PUVA Therapy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology