Synthesis and biological evaluation of 9-substituted tetracycline derivatives.
The synthesis of 9-substituted tetracycline derivatives has been accomplished by the reaction of C9 diazonium tetrafluoroborate tetracycline salts with organotin reagents under modified Stille coupling conditions. Several of these unreported derivatives show promising in vitro biological activity against tetracycline resistant and antibiotic resistant bacteria.
Department of Physical Sciences, Eastern Connecticut State University, Center for Antimicrobial Resistance, Goddard Hall, Willimantic, CT 06226, USA. kozad@easternct.edu
Darrell J
DJ
Koza
Yaw A
YA
Nsiah
D024901:Drug Resistance, Multiple, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013753:Tetracycline Resistance; D013754:Tetracyclines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D013754:Tetracyclines