Vaccines for Proteus mirabilis in urinary tract infection.
Proteus mirabilis is a documented cause of urinary tract infection (UTI) in the complicated urinary tract. Urease-mediated urea hydrolysis is responsible for both virulence of the organism and the ability to cause urolithiasis. A urease-negative mutant of P. mirabilis is unable to initiate stone formation and colonizes the kidney at a significantly lower rate. The considerable pathology caused by P. mirabilis warrants the development of a vaccine. We have initiated the advancement of vaccine studies and have determined that the MR/P fimbria, a surface adhesin of P. mirabilis, is a promising vaccine candidate. Successful vaccination would be expected both to prevent colonization by P. mirabilis and urolithiasis.
Li
Xin
X
Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 W. Baltimore Street, Room 13-009, Baltimore, MD 21201, USA.
Mobley
Harry L T
HL
D001428:Bacterial Vaccines / Q000627:therapeutic use*; D006801:Humans; D011512:Proteus Infections / Q000150:complications / Q000382:microbiology / Q000517:prevention & control*; D011513:Proteus mirabilis / Q000302:isolation & purification* / Q000472:pathogenicity; D014510:Urease / Q000378:metabolism; D014545:Urinary Calculi / Q000382:microbiology; D014552:Urinary Tract Infections / Q000150:complications / Q000382:microbiology / Q000517:prevention & control*; D014774:Virulence
D001428:Bacterial Vaccines; D014510:Urease