Identification of CAG repeat-containing genes expressed in human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases.
To obtain novel candidate genes for autosomal dominant spinocerebellar ataxia and other neurodegenerative disorders in which gene mutations remain unidentified, we screened a human fetal brain cDNA library using (CAG)(10) repeat probes. Sixteen cDNAs were isolated and mapped to chromosomes 1, 2, 3, 6, 9, 13, 15, 16, 22, and X. Although we failed to detect abnormal CAG repeat expansion within these genes in Japanese patients with inherited neurodegenerative diseases, these genes remain potential candidate genes for neurodegenerative diseases that feature anticipation.
Tachikawa
Masaji
M
Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, 2-2-B9 Yamadaoka, Suita, Osaka 565-0871, Japan.
Nagai
Yoshitaka
Y
Nakamura
Koichiro
K
Kobayashi
Kazuhiro
K
Fujiwara
Tsutomu
T
Han
Hye-Jung
HJ
Nakabayashi
Yuko
Y
Ichikawa
Yaeko
Y
Goto
Jun
J
Kanazawa
Ichiro
I
Nakamura
Yusuke
Y
Toda
Tatsushi
T
D001921:Brain / Q000378:metabolism*; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000302:isolation & purification; D015723:Gene Library; D005799:Genes, Dominant; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D015345:Oligonucleotide Probes; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020754:Spinocerebellar Ataxias / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics*
D018076:DNA, Complementary; D005819:Genetic Markers; D015345:Oligonucleotide Probes