Say when: reversible control of gene expression in the mouse by lac.
In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator-repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse.
Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA. hs2n@virginia.edu
Heidi
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Scrable
D000483:Alleles; D000818:Animals; D004251:DNA Transposable Elements; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000235:genetics; D005786:Gene Expression Regulation; D007763:Lac Operon / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D014442:Monophenol Monooxygenase / Q000235:genetics; D013997:Time Factors; D019076:Transgenes
D004251:DNA Transposable Elements; D014442:Monophenol Monooxygenase