Transforming growth factor-beta enhances human T-cell leukemia virus type I infection.
Human T-cell leukemia virus type I (HTLV-I), the causative agent of adult T-cell leukemia/lymphoma, is transmitted vertically by breast milk and sexually by semen. The transforming growth factor-beta (TGF-beta), a pleiotropic cytokine that is abundant in breast milk and semen, facilitates replication of HTLV-I in lymphocytes derived from asymptomatic HTLV-I carriers and transmission to cord blood lymphocytes in vitro. Transient expression assays revealed that TGF-beta can transactivate HTLV-I long terminal repeat promoter. These results suggest that TGF-beta may play a role in replication and transmission of HTLV-I.
Moriuchi
Masako
M
Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan.
Moriuchi
Hiroyuki
H
D002478:Cells, Cultured; D005312:Fetal Blood / Q000166:cytology / Q000821:virology; D015490:HTLV-I Infections / Q000635:transmission* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000821:virology; D008895:Milk, Human / Q000821:virology; D011401:Promoter Regions, Genetic / Q000187:drug effects; D012661:Semen / Q000821:virology; D020079:Terminal Repeat Sequences / Q000235:genetics; D015533:Transcriptional Activation; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D016212:Transforming Growth Factor beta