[Effect of Cerebral on the immune system in experimental hemorrhagic stroke].
Data on the development of three experimental models of hemorrhagic stroke in mice are reported. The models differ in the extent of damage. From the standpoint of the immunopharmacological investigation, most adequate model is provided by the light acute brain circulation disorder (LABCD). In the LABCD model, the hemorrhagic stroke is characterized by reduction in the thymus weight, inhibition of the antibody (hemolysin) synthesis, and enhancement of the delayed type hypersensitivity response. The new antistroke drug cerebral decreased (especially after intranasal administration) the level of lethality in experimental animals and improved the immunological indices.
Arkad'ev
V G
VG
Department of Pathophysiology, Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
Novik
L V
LV
Pustovarov
A Iu
AIu
Maksimov
Iu N
IuN
Makarenko
A N
AN
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000276:immunology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007107:Immune System / Q000187:drug effects*; D008297:Male; D051379:Mice; D020521:Stroke / Q000150:complications / Q000276:immunology*
D000276:Adjuvants, Immunologic