Spinal epidural haematoma as a result of warfarin/fluconazole drug interaction.
This is the first reported case in the emergency medicine literature of a drug interaction between warfarin and fluconazole. We present a case of spinal epidural haematoma and summarize four other case reports reported elsewhere from 1988 to 1996. We admonish emergency physicians to be aware of this dangerous drug combination. Warfarin and fluconazole are frequently encountered drugs in the emergency department and thus any interaction between these drugs is of considerable importance.
Allison
E J
EJ
Department of Emergency Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
McKinney
T J
TJ
Langenberg
J N
JN
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage* / Q000009:adverse effects*; D006407:Hematoma, Epidural, Cranial / Q000139:chemically induced*; D006801:Humans; D008297:Male; D013118:Spinal Cord Diseases / Q000139:chemically induced; D014859:Warfarin / Q000008:administration & dosage* / Q000009:adverse effects*
D000925:Anticoagulants; D000935:Antifungal Agents; D014859:Warfarin; D015725:Fluconazole