Carcinoma of the larynx: the Dutch national guideline for diagnostics, treatment, supportive care and rehabilitation.
OBJECTIVE
This evidence based guideline aims to facilitate proper management and to prevent diverging views concerning diagnosis, treatment and follow-up of carcinoma of the larynx between the major referral centers for head and neck cancer in The Netherlands.


METHODS
A multidisciplinary committee was formed representing all medical and paramedical disciplines involved in the management of laryngeal cancer and all head and neck oncology centers in The Netherlands. This committee reviewed the literature and formulated statements and recommendations based on the level of evidence and consistency of the literature data. Where reliable literature data were not available, recommendations were based on expert opinion.


RESULTS
Strict criteria have been proposed for the radiological diagnostic procedures as well as for the pathology report. For carcinoma in situ and severe dysplasia, microsurgery, preferably by laser, is proposed. For all other stages of invasive carcinoma, a full course of radiotherapy as a voice conserving therapy is the treatment of choice. Only in cases with massive tumor volumes with invasion through the laryngeal skeleton, primary surgery is inevitable. For rehabilitation and supportive care, minimal criteria are described. Due to the complexity of therapy and relative rarity of larynx carcinoma, all patients should be seen at least once in a dedicated head and neck clinic.


CONCLUSIONS
This guideline for the management of larynx carcinoma was produced by a multidisciplinary national committee and based on scientific evidence wherever possible. This procedure of guideline development has created the optimal conditions for nationwide acceptance and implementation of the guideline.
Institute of Radiotherapy, University Medical Center St. Radboud, Geert Groteplein 32, 6525 GA Nijmegen, The Netherlands.
Johannes H A M
JH
Kaanders
Gerrit Jan
GJ
Hordijk
D002277:Carcinoma / Q000175:diagnosis* / Q000534:rehabilitation / Q000628:therapy*; D019317:Evidence-Based Medicine; D006291:Health Policy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000534:rehabilitation / Q000628:therapy*; D007830:Larynx; D009426:Netherlands; D017410:Practice Guidelines as Topic; D012944:Social Support