Cyclic AMP and the reverse transformation reaction.
Traditional methods for cancer treatment have been aimed at killing the cancer cells. Unfortunately this approach all too often is accompanied by harmful killing of normal cells. The present paper describes an experimental program in our laboratory in which cancer cells are treated so as to revert to normal cell behavior. This process, which we have named reverse transformation, appears to offer considerable hope in the treatment of a large number of malignancies.
Puck
Theodore T
TT
Eleanor Roosevelt Institute, Denver, Colorado 80206, USA. peggy@eri.uchsc.edu
Webb
Patricia
P
Johnson
Robert
R
D000818:Animals; D001921:Brain / Q000166:cytology; D003994:Bucladesine / Q000494:pharmacology*; D016466:CHO Cells; D048429:Cell Size; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006224:Cricetinae; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D010766:Phosphorylation; D013738:Testolactone / Q000031:analogs & derivatives* / Q000494:pharmacology
C018155:testololactone; D003994:Bucladesine; D013738:Testolactone; D000242:Cyclic AMP