Depression in palliative care: a systematic review. Part 2. Treatment.
OBJECTIVE
To summarize available literature containing data on the treatment of depression in palliative care patients.


METHODS
A systematic review was conducted using extensive electronic databases and hand searches. All randomized controlled trials (RCTs) of interventions for depression in patients with advanced disease were eligible.


RESULTS
Three RCTs assessed pharmacological treatments. Of these, two were placebo controlled and assessed mianserin and thioridazine. The third compared two antidepressants. There were no RCTs that specifically assessed psychotherapy for patients with depression.


CONCLUSIONS
There are too few adequate studies to draw clear conclusions about management of depression in this setting. The treatment of depression in patients with advanced disease must, for now, be informed by the larger body of evidence on effective treatments for depression in patients with either no physical illness or less severe medical conditions.
Stanford University School of Medicine, USA.
Kelly Lan
KL
Ly
Jayne
J
Chidgey
Julia
J
Addington-Hall
Matthew
M
Hotopf
D000928:Antidepressive Agents / Q000627:therapeutic use; D003866:Depressive Disorder / Q000628:therapy*; D005544:Forecasting; D006801:Humans; D009369:Neoplasms / Q000523:psychology*; D010166:Palliative Care; D016032:Randomized Controlled Trials as Topic; D019452:Terminally Ill / Q000523:psychology
D000928:Antidepressive Agents