Odontogenic carcinoma: a functional genomic comparison with oral mucosal squamous cell carcinoma.
Intraosseous squamous cell carcinomas of the mandible arise de novo or secondary to a tumor or transformed cyst epithelium. Current diagnostic tests frequently fail to distinguish between these tumors, leading to confusing classification schemes. We report the functional genomic analysis of a mandibular odontogenic carcinoma. Malignant keratinocytes from the lesion were isolated using laser capture microdissection. Target sample generated from the total RNA of the LCM-procured cells was used to hybridize high-density oligonucleotide arrays. Functional genomic analysis of the odontogenic carcinoma database compared with four oral mucosal squamous cell carcinoma gene expression databases was performed. Preliminary results suggest a small subset of genes distinguish this odontogenic carcinoma from oral mucosal epidermoid carcinomas.
Alevizos
Ilias
I
Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA.
Blaeser
Bart
B
Gallagher
George
G
Ohyama
Hiroe
H
Wong
David T W
DT
Todd
Randy
R
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics*; D030541:Databases, Genetic; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D006801:Humans; D008339:Mandibular Neoplasms / Q000175:diagnosis / Q000235:genetics*; D009808:Odontogenic Tumors / Q000175:diagnosis / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics
D012334:RNA, Neoplasm