Cardiac Ca(2+) regulation and the tuna fish sandwich.
Following myocardial ischemia and reperfusion, there is a risk of fatal arrhythmias that result from damage to cellular Ca(2+) homeostasis mechanisms. n-3 Polyunsaturated fatty acids seem to protect against these arrhythmias by mechanisms involving the sarcoplasmic reticulum and the sarcolemma.
Unit of Cardiac Physiology, Department of Medicine, Manchester University, Manchester M13 9PT, UK.
Stephen
S
O'Neill
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000178:diet therapy*; D009206:Myocardium / Q000378:metabolism*; D014280:Triglycerides / Q000627:therapeutic use*; D014413:Tuna
D002316:Cardiotonic Agents; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; C077446:Pikasol; D002118:Calcium