[Effect of dimephosphon and xidifon on parameters of lipid peroxidation and the antioxidant system in rats subjected to the long-term administration of prednisolone].
Experiments in rats with an osteoporosis model induced by the chronic administration of prednisolone (50 mg/kg, p.o., over 14 days) showed that the drug differently affects the lipid peroxidation (LPO) rate and the antioxidant system activity. Xydiphone (45 mg/kg, p.o.) administered over 14 days exhibited a perooxidant action. Dimephosphon (208 mg/kg, p.o.) administered over the same period of time produced an antioxidant effect as manifested by a growth in the catalase activity, an increase in the content of ceruloplasmin and glutathione, and a decrease in the content of LPO products in the blood serum and liver tissues. The results of combined administration of prednisolone and phosphonates indicate good prospects of the dimephosphon treatment as a means of normalization of the LPO and antioxidant system functioning disturbed by prolonged use of glucocorticoids.
Valeeva
I Kh
IKh
Central Research Laboratory, Kazan State Medical University, ul. Butlerova 49, Kazan, Tatarstan, 420012 Russia.
Ziganshina
L E
LE
Burnashova
Z A
ZA
Ziganshin
A U
AU
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D012968:Etidronic Acid / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010024:Osteoporosis / Q000097:blood / Q000139:chemically induced / Q000378:metabolism; D010084:Oxidation-Reduction; D011239:Prednisolone / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D009943:Organophosphorus Compounds; C049638:dimephosphon; D011239:Prednisolone; D012968:Etidronic Acid