Vesicular transport: the core machinery of COPI recruitment and budding.
Vesicular transport is the predominant mechanism for exchange of proteins and lipids between membrane-bound organelles in eukaryotic cells. Golgi-derived COPI-coated vesicles are involved in several vesicular transport steps, including bidirectional transport within the Golgi and recycling to the ER. Recent work has shed light on the mechanism of COPI vesicle biogenesis, in particular the machinery required for vesicle formation. The new findings have allowed us to generate a model that covers the cycle of coat recruitment, coat polymerization, vesicle budding and uncoating.
Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany. walter.nicle@urz.uni-heidelberg.de
Walter
W
Nickel
Britta
B
Brügger
Felix T
FT
Wieland
D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D022181:COP-Coated Vesicles / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D008954:Models, Biological; D010750:Phosphoproteins / Q000378:metabolism
D010750:Phosphoproteins