Role of bacteriophage MAV1 as a mycoplasmal virulence factor for the development of arthritis in mice and rats.
The lysogenic bacteriophage MAV1 has been shown to be a virulence factor for the development of arthritis in rats infected with Mycoplasma arthritidis. In the present study, arthritis was evaluated by histopathologic examination to demonstrate that MAV1 is a virulence factor not only in the rat but also in the mouse. Specifically, the MAV1 lysogen 158L3-1 was more virulent than the nonlysogen strain 158 in DBA/2NCr, C3H/HeNCr, C3H/HeJ, and C3Smn.CB17-Prkdc(scid)/J mice, as well as in LEW rats.
Department of Genomics and Pathobiology, University of Alabama at Birmingham, 35294-0019, USA.
Anh-Hue T
AH
Tu
J Russell
JR
Lindsey
Trenton R
TR
Schoeb
Ada
A
Elgavish
Huilan
H
Yu
Kevin
K
Dybvig
D000818:Animals; D001168:Arthritis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D001435:Bacteriophages / Q000472:pathogenicity / Q000502:physiology*; D005260:Female; D006651:Histocytochemistry; D007596:Joints / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D016513:Mice, SCID; D009174:Mycoplasma / Q000472:pathogenicity*; D009175:Mycoplasma Infections / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D011917:Rats, Inbred Lew; D014774:Virulence