Regional variation in CCR5-Delta32 gene distribution among women from the US HIV Epidemiology Research Study (HERS).
The CCR5-Delta32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5-Delta32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3.1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.
Downer
M V
MV
Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Hodge
T
T
Smith
D K
DK
Qari
S H
SH
Schuman
P
P
Mayer
K H
KH
Klein
R S
RS
Vlahov
D
D
Gardner
L I
LI
McNicholl
J M
JM
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D015497:HIV-1; D006579:Heterozygote; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D019713:Receptors, CCR5 / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics; D001741:Black or African American
D019713:Receptors, CCR5; D004247:DNA