Synergistic and potentiating effects of ranitidine and two new anti-ulcer compounds from Enantia chlorantha and Voacanga africana in experimental animal models.
TN, an alkaloid from the fruit of Voacanga africana and a protoberberine-type alkaloid (7,8-dihydro-8-hydroxypalmatine) (1), obtained from the bark of Enantia chlorantha were tested for ulcer preventive and antisecretory activity in combination with ranitidine. When tested alone (50 and 100 mg/kg, p.o.), TN and 1 achieved their anti-ulcer actions through reduced gastric secretion and improved mucus production. 1:1 combinations of 1 and the antisecretory agents (25/25 and 50/50 mg/kg) resulted in significant reduction of ulceration under highly acidic conditions (50-70 mEq/l), suggesting potentiating effects. A combination of TN and ranitidine led to synergistic antisecretory effects.
Tan
P V
PV
Department of Animal Biology and Physiology, University of Yaounde I, Cameroon.
Nyasse
B
B
Dimo
T
T
Wafo
P
P
Akahkuh
B T
BT
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005638:Fruit / Q000737:chemistry; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D009093:Mucus / Q000378:metabolism; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011708:Pylorus / Q000502:physiology; D011899:Ranitidine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D011899:Ranitidine