Pharmacological properties of traditional medicines (XXVII). Interaction between Ephedra Herb and Gypsum under hyperthermal conditions in rats.
There are many important considerations in the interactions among the herbal constituents in a prescription of traditional Chinese medicine (TCM). Ephedra Herb [Chinese characters: see text] (Eph) is described a warm and acrid agent in TCM. The combination of Eph and Gypsum [Chinese characters: see text] (Eph-Gyp) shows specific actions in patients with different body temperatures. Previous reports suggested that Gypsum prevents the thermogenesis effect induced by ephedrine at an ambient temperature of 22 degrees C. In this investigation, the properties of Eph-Gyp in hyperthermal rats were studied in detail. It was shown that Gypsum Extract (GyE) enhanced the thermogenesis of Eph in hyperthermal rats, although not in normal rats. The results support not only the opposite actions of Eph-GyE but also the clinical differences in the symptomatic patterns of body temperature for Makyo-Kanseki-To [Chinese characters: see text] and Dai-Seiryu-To [Chinese characters: see text].
Yuan
Dan
D
Department of Traditional Chinese Medicinal Sciences, Shenyang Pharmaceutical University, China.
Sunouchi
Hiroshi
H
Sakurai
Tetsurou
T
Saito
Ken-ichi
K
Kano
Yoshihiro
Y
D000678:Amygdalin / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D029789:Ephedra / Q000737:chemistry*; D004809:Ephedrine / Q000494:pharmacology* / Q000627:therapeutic use; D005334:Fever / Q000188:drug therapy*; D008297:Male; D008516:Medicine, Chinese Traditional; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D022722:Thermogenesis / Q000187:drug effects*; D013817:Thermography
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C049093:makyokansekito; D000678:Amygdalin; D004809:Ephedrine