Ileocecal valve as substitute for the missing pyloric sphincter after partial distal gastrectomy.
OBJECTIVE
Accelerated gastric emptying (including dumping syndrome) occurs frequently after gastric resections, largely resulting from rapid entry of meal contents into the small intestine. The authors hypothesized that an ileocecal segment used as an interpositional graft placed between the remaining part of the stomach and the small intestine would slow down food transit and thus replace pyloric function.


METHODS
Thirty Göttingen minipigs were randomized into three groups. Group 1: partial gastrectomy and Roux-en-Y reconstruction; Group 2: partial gastrectomy and ileocecal interpositional graft; and Group 3: sham laparotomy. Gastric emptying in the nonsedated animals was quantified using radioscintigraphy at 3 and 6 months postoperatively. The animals ingested 300 grams of soft food containing 99mTc labeled resin- pellets using a technique previously described. Data were analyzed using ANOVA.


RESULTS
Three months postoperatively, the ileocecal group had a significantly prolonged gastric emptying time compared with the Roux-en-Y group, but gastric emptying time was also significantly faster compared to the control group (sham laparotomy). After 6 months no significant difference was seen between the ileocecal group and the controls, while emptying rates were still significantly faster in the Roux-en-Y group.


CONCLUSIONS
Reconstruction of the gastric reservoir with an ileocecal segment largely restores gastric emptying patterns of food in minipigs. Six months postoperatively, gastric emptying time is similar to that of controls, and significantly slower when compared with the group with Roux-en-Y reconstruction. These results suggest that the ileocecal interposition graft could offer specific advantages over current reconstruction procedures.
Metzger
Jürg
J
Department of Surgery, University Hospital Basel, Basel, Switzerland. metzgerj@bluewin.ch
Degen
Lukas P
LP
Beglinger
Christoph
C
Siegemund
Martin
M
Studer
Wolfgang
W
Heberer
Michael
M
Harder
Felix
F
von Flüe
Markus O
MO
D000713:Anastomosis, Roux-en-Y; D000818:Animals; D003106:Colon / Q000601:surgery*; D004377:Dumping Syndrome / Q000209:etiology / Q000517:prevention & control*; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods*; D005746:Gastric Emptying; D005772:Gastrointestinal Transit; D005951:Glucose Tolerance Test; D007080:Ileocecal Valve / Q000637:transplantation*; D007082:Ileum / Q000601:surgery*; D011708:Pylorus / Q000502:physiology; D011897:Random Allocation; D013556:Swine, Miniature