[Study of serum leptin level in patients with obstructive sleep apnea].
OBJECTIVE
To explore the change of serum leptin in patients with obstructive sleep apnea syndrome (OSAS).


METHODS
Polysomnography was performed in 58 patients with OSAS and in 21 simple obese controls without differences in age and body mass index (BMI). Serum leptin level was measured by radioimmunoassay.


RESULTS
(1) The serum leptin level in patients with OSAS was higher, in both males (6.1 +/- 1.7) microg/L and females (19.5 +/- 9.9) microgram/L, than that in the simple obese controls [male (4.5 +/- 1.7) microgram/L, female (10.5 +/- 2.4) microgram/L] (P < 0.01, P < 0.05). (2) Serum leptin levels were significantly correlated with BMI in both OSAS patients (r = 0.64, P < 0.01) and simple obese controls (r = 0.59, P < 0.01), but only in OSAS patients was the leptin level significantly correlated with apnea and hypopnea index (AHI) (r = 0.47, P < 0.01) and with neck circumference (r = 0.64, P < 0.01).


CONCLUSIONS
Serum leptin levels were higher in OSAS patients than in simple obese controls. Besides obesity and neck circumference, OSAS may also influence the leptin system, resulting in increased serum leptin level.
Institute of Respiratory Disease, China Medical University, Shenyang 110001, China.
Guangming
G
Jin
Wei
W
Wang
Jian
J
Kang
Ying
Y
Wu
Xianming
X
Hou
Runjiang
R
Yu
D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009333:Neck; D009765:Obesity / Q000378:metabolism*; D020181:Sleep Apnea, Obstructive / Q000097:blood*
D020738:Leptin