Lipid A structures containing novel lipid moieties: synthesis and adjuvant properties.
Structurally well-defined immune stimulatory molecules are important components of new generation molecular vaccines. In this paper, the design and synthesis of two lipid A analogues containing an unnatural tri-lipid acyl group are described. In a totally synthetic liposomal vaccine system, these re-designed lipid A analogues demonstrate potent immune stimulatory properties including antigen specific T-cell activation.
Jiang
Zi Hua
ZH
Biomira Inc., 2011-94 Street, Edmonton, T6N 1H1, Alberta, Canada. rkoganty@biomira.com
Bach
Mimi V
MV
Budzynski
Wladyslaw A
WA
Krantz
Mark J
MJ
Koganty
R Rao
RR
Longenecker
B Michael
BM
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D015195:Drug Design; D008050:Lipid A / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology
D000276:Adjuvants, Immunologic; D008050:Lipid A; D014612:Vaccines