Orientia tsutsugamushi inhibits apoptosis of macrophages by retarding intracellular calcium release.
Orientia tsutsugamushi shows both pro- and antiapoptotic activities in infected vertebrate cells. Apoptosis of THP-1 cells induced by beauvericin was inhibited by O. tsutsugamushi infection. Beauvericin-induced calcium redistribution was significantly reduced and retarded in cells infected with O. tsutsugamushi. Antiapoptotic activities of O. tsutsugamushi in infected cells are most probably due to inhibition of the increase in the cytosolic calcium concentration.
Kim
Mee-Kyung
MK
Department of Microbiology, Inha University College of Medicine, Inchon 400-103, Republic of Korea.
Seong
Seung-Yong
SY
Seoh
Ju-Young
JY
Han
Tae-Hee
TH
Song
Hyeon-Je
HJ
Lee
Ji-Eun
JE
Shin
Jung-Hoon
JH
Lim
Byung-Uk
BU
Kang
Jae-Seung
JS
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D047630:Depsipeptides; D006801:Humans; D007424:Intracellular Fluid; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D012285:Orientia tsutsugamushi / Q000502:physiology*; D010455:Peptides
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010455:Peptides; C004456:beauvericin; D002118:Calcium