Anticancer and antithrombin activity of Russian plants.
A chromogenic bioassay was utilized to determine the antithrombin activity of the methylene chloride and methanol extracts prepared from forty-five plants of Russia. Mouse leukemia cells (L1210) were utilized to screen these extracts for activity against cancer. The results indicated that eight plant extracts demonstrated 90% or higher activity in the inhibition of thrombin. Also, nine methanol extracts demonstrated activity of 90% or higher in the inhibition of mouse leukemia L1210 cells. The methanol extracts of Quercus robur and Sanguisorba officinalis demonstrated high activity against both thrombin and cancer.
Goun
Elena A
EA
Department of Chemistry, University of Central Florida, Orlando, FL 32826, USA.
Petrichenko
V M
VM
Solodnikov
S U
SU
Suhinina
T V
TV
Kline
Martin A
MA
Cunningham
Glenn
G
Nguyen
Chi
C
Miles
Howard
H
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D007938:Leukemia / Q000473:pathology*; D000432:Methanol; D008752:Methylene Chloride; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry* / Q000145:classification; D012426:Russia; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000925:Anticoagulants; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D008752:Methylene Chloride; D013917:Thrombin; D000432:Methanol