[Dependence of galodif pharmacokinetics on duration of its administration].
Pharmacokinetics of the new antiepileptic drug galodif was experimentally studied on rats. A single administration of the anticonvulsant is followed by slow elimination. A five-day administration leads to a significant acceleration of the drug elimination due to activation of the cytochrome P-450 dependent monooxygenase system of liver. After a 14-day administration, the elimination rate decreases as compared to that for the five-day treatment, while being still higher than in the case of single administration.
Institute of Psychological Health, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Sosnovyi Bor, Tomsk, 634014 Russia.
E V
EV
Kanov
T P
TP
Novozheeva
A S
AS
Saratikov
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010671:Phenylurea Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D051381:Rats
D000927:Anticonvulsants; D010671:Phenylurea Compounds; C068164:galodif