Molecular and cellular characterization of transferrin receptor 2.
Iron is an essential component of many biological processes. However, an excess of iron in the body is also toxic; thus, the levels of this element are tightly regulated. Our knowledge of the mechanism by which iron levels are maintained has been bolstered by the dramatic increase in the discovery of novel molecules implicated in iron homeostasis. The transferrin receptor-transferrin pathway is the main mechanism by which cells take up iron. The recently identified homolog of transferrin receptor, its characterization and its role in iron metabolism is the subject of this review.
Membrane Transport Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. nathanS@qimr.edu.au
V Nathan
VN
Subramaniam
Lesa
L
Summerville
Daniel F
DF
Wallace
D000595:Amino Acid Sequence; D000818:Animals; D002897:Chromosomes, Human, Pair 7; D033481:Chromosomes, Mammalian; D004705:Endocytosis; D006432:Hemochromatosis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D011990:Receptors, Transferrin / Q000737:chemistry* / Q000502:physiology*; D014018:Tissue Distribution; D014168:Transferrin / Q000502:physiology
D011990:Receptors, Transferrin; C503640:TFR2 protein, human; D014168:Transferrin; D007501:Iron