Diagnostic intraocular aspiration cytology of choroidal melanoma.
Fine-needle aspiration cytology (FNAC) was performed on an intraocular mass in a 32-yr-old Indian woman and a cytologic diagnosis of malignant melanoma was made, supported by immunocytochemistry. The cytologic features included spindle-shaped tumour cells with minimal pleomorphism and the presence of nuclear grooves. No intracellular pigment was identified; however, positivity for HMB-45 allowed a rapid and reliable diagnosis. The utility of FNAC in an atypical presentation of choroidal melanoma is discussed.
Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi 110029, India. lokeshkashyap@yahoo.com
Seema
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Kashyap
Seema
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Sen
M C
MC
Sharma
Anita
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Sethi
D000328:Adult; D000951:Antigens, Neoplasm; D001707:Biopsy, Needle; D002830:Choroid Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins