Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation.
Neuropeptide Y (NPY) is a 36 amino acid peptide well known for its role in regulating food intake and energy homeostasis. It has previously been shown that the NPY Y2 receptor is required for a full biological response to leptin in the central nervous system. We have examined the impact of this receptor on plasma levels of lipid and cholesterol in wild type and obese (ob/ob) mice. The results show that an absence of Y2 in female mice has no effect on cholesterol level in normal lean mice but profoundly decreases serum cholesterol and glucose levels in ob/ob mice. We conclude that NPY, interacting with the Y2 receptor, participates in cholesterol and glucose homeostasis of obese mice.
Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institute, Dorktorsringen 12A, S-17177, Stockholm, Sweden.
Philippe
P
Naveilhan
Lennart
L
Svensson
Susanne
S
Nyström
A Jonas
AJ
Ekstrand
Patrik
P
Ernfors
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003433:Crosses, Genetic; D005260:Female; D006937:Hypercholesterolemia / Q000235:genetics* / Q000473:pathology; D006943:Hyperglycemia / Q000235:genetics* / Q000473:pathology; D020738:Leptin / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008820:Mice, Obese; D008822:Mice, Transgenic; D009478:Neuropeptide Y / Q000235:genetics / Q000502:physiology*; D017476:Receptors, Neuropeptide Y / Q000235:genetics* / Q000502:physiology*; D013696:Temperature; D013997:Time Factors
D001786:Blood Glucose; D020738:Leptin; D008055:Lipids; D008074:Lipoproteins; D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor; D002784:Cholesterol