Event-related fMRI responses in the human frontal eye fields in a randomized pro- and antisaccade task.
We examined whether the frontal eye fields (FEF) are involved in the suppression of reflexive saccades. Simultaneous recording of horizontal eye movements and functional magnetic resonance imaging enabled us to perform a randomized pro- and antisaccade task and to sort blood oxygenation level dependent (BOLD) time series on the basis of task performance. Saccadic reaction time distributions were comparable across tasks indicating a similar effort in preprocessing of the saccades. Furthermore, we found similar BOLD activation in FEF during both correctly performed pro- and antisaccades. Frontal eye field activation started prior to target presentation and saccade generation. While we observed only few erroneous antisaccades, these were associated with a decrease in BOLD activity prior to target presentation, and increased BOLD activity after target presentation relative to correctly performed antisaccades. These findings are consistent with a role of the FEF in the suppression of reflexive saccades. The increase in activity after target presentation for antisaccade errors can only be indirectly linked to such a role but may also reflect activity related to the generation of a correction saccade. Frontal eye field BOLD activity may further represent general arousal, preparatory set, short-term memory, or salience-map related activity.
Laboratory for Experimental Ophthalmology and Department of Biological Psychiatry, School for Behavioral and Cognitive Neurosciences, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. f.w.cornelissen@med.rug.nl
Frans W
FW
Cornelissen
Hubert
H
Kimmig
Mark
M
Schira
Roland M
RM
Rutschmann
R Paul
RP
Maguire
Annelies
A
Broerse
Johan A
JA
Den Boer
Mark W
MW
Greenlee
D000328:Adult; D000704:Analysis of Variance; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D012438:Saccades / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*