An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids.
3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench". This technique was further studied and evaluated on other aryl halides in the preparation of arylboronic acids.
Process Research Department, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. wenjie_li@merck.com
Wenjie
W
Li
Dorian P
DP
Nelson
Mark S
MS
Jensen
R Scott
RS
Hoerrner
Dongwei
D
Cai
Robert D
RD
Larsen
Paul J
PJ
Reider