[The difference of the bismuth absorption from a single colloidal bismuth pectin therapy and quadruple therapy for eradicating Helicobacter pylori infection].
OBJECTIVE
To investigate whether the quadruple therapy influences the absorption of bismuth from Colloidal Bismuth Pectin (CBP).


METHODS
24 male Wistar rats weighing from 400 g to 500 g were randomly divided into two groups: CBP group (group A(1)) and CBP+AMO+MTR+ LAN group (group A(2)). The serum bismuth concentration was observed at 0,1,2,3,4,5,6 hour after these medicines were fed. Other 24 male Wistar rats weighing from 200 g to 250 g were randomly divided into two groups: CBP group (group B(  1)), CBP+AMO+MTR+LAN group (group B(2)). These medicines had been taken every day for 14 days. The accumulation of bismuth in the heart, brain, kidney and liver of rats were detected eight weeks later.


RESULTS
The serum peak value of bismuth is not significantly different between group A(1) and group A(2) (P > 0.05), but the peak time of bismuth of the group A(2) is one hour earlier than that of group A(1). The amounts of the accumulation of bismuth in the kidney are 154 +/- 15 ng/g and 212 +/- 20 ng/g in the group B(1) and B(2) respectively at the eighth week after the medicines were fed in rats with a significant difference (P < 0.05).


CONCLUSIONS
The quadruple therapy causes an increase of the absorption and the accumulation of bismuth from CBP in the kidney in rats.
Zhang
Shutian
S
Digestive Diseases Dep, Beijing Friendship Hospital affiliated to Capital University of Medical Sciences, Beijing 100050, China.
Zhang
Songhua
S
Yu
Zhonglin
Z
Wang
Yongfang
Y
D000042:Absorption; D000818:Animals; D001729:Bismuth / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003102:Colloids; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000378:metabolism; D016480:Helicobacter pylori; D008297:Male; D010368:Pectins / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D003102:Colloids; D010368:Pectins; D001729:Bismuth