Adjuncts to preparing wounds for closure: hyperbaric oxygen, growth factors, skin substitutes, negative pressure wound therapy (vacuum-assisted closure).
Achieving closure in a chronic wound requires provision of adequate oxygen delivery to the tissue, adequate protein and other nutritional factors, a moist environment, an appropriate inflammatory milieu, dèbridement, and correction of contributing medical diagnoses. In some patients, these conditions are achieved easily, whereas in others, greater effort is required. Adjunctive treatments, including HBO2, growth factors, skin substitutes, and negative-pressure wound therapy (e.g., V.A.C.) can provide the proper conditions for healing in appropriately selected patients.
Hopf
H W
HW
Department of Anesthesia, Perioperative Care, and Surgery, Wound Healing Laboratory, University of California-San Francisco, HSW 1652, Box 0522, 513 Parnassus Avenue, San Francisco, CA 94143-0522, USA. hhopf@itsa.ucsf.edu
Humphrey
L M
LM
Puzziferri
N
N
West
J M
JM
Attinger
C E
CE
Hunt
T K
TK
D002908:Chronic Disease; D003131:Combined Modality Therapy; D018409:Foot Injuries / Q000601:surgery / Q000628:therapy*; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D006931:Hyperbaric Oxygenation; D017768:Skin, Artificial; D013396:Suction; D014945:Wound Healing
D006133:Growth Substances