Automated detection of remote homology.
The classification of a newly identified protein as a member of a superfamily is important for focusing experiments on its most likely functions. Such classification, often performed by hand, has now been fully automated. This sophisticated new approach takes into account not only alignment scores but also a number of other computable attributes, such as functional sites deduced from sequence conservation patterns.
Dietmann
Sabine
S
Structural Genomics Group, EMBL-EBI Research Programme, Cambridge CB10 1SD, UK.
Fernandez-Fuentes
Narcis
N
Holm
Liisa
L
D001331:Automation; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D019143:Evolution, Molecular; D005810:Multigene Family; D011506:Proteins / Q000737:chemistry / Q000145:classification* / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D017386:Sequence Homology, Amino Acid
D011506:Proteins