Clinical significance of bronchoalveolar eosinophils in childhood asthma.
To evaluate the relationship between clinical parameters and differential cell counts, bronchoalveolar lavage was performed in 79 asthmatic infants and children with unusual asthma. Multivariate analysis showed significant associations between (1) allergic asthma and the presence of alveolar eosinophils and (2) persistent and longer asthma and an increased number of alveolar neutrophils. Our results provide the first evidence that in asthmatic infants and children eosinophilic inflammation is related to allergic sensitization.
Just
Jocelyne
J
Service de Pneumologie Pédiatrique, Hôpital d'Enfants-Armand Trousseau, Paris, France.
Fournier
Lydia
L
Momas
Isabelle
I
Zambetti
Chiara
C
Sahraoui
Fathia
F
Grimfeld
Alain
A
D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D007223:Infant; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology