Cardiac Ca(2+) regulation and the tuna fish sandwich.
Following myocardial ischemia and reperfusion, there is a risk of fatal arrhythmias that result from damage to cellular Ca(2+) homeostasis mechanisms. n-3 Polyunsaturated fatty acids seem to protect against these arrhythmias by mechanisms involving the sarcoplasmic reticulum and the sarcolemma.
O'Neill
Stephen
S
Unit of Cardiac Physiology, Department of Medicine, Manchester University, Manchester M13 9PT, UK.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000178:diet therapy*; D009206:Myocardium / Q000378:metabolism*; D014280:Triglycerides / Q000627:therapeutic use*; D014413:Tuna
D002316:Cardiotonic Agents; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; C077446:Pikasol; D002118:Calcium