Adiponectin and development of type 2 diabetes in the Pima Indian population.
Adiponectin is a collagen-like circulating protein secreted by adipocytes that is proposed to mediate obesity-related resistance to insulin. In a case-control series, we assessed the role of adiponectin in later development of type 2 diabetes in 70 patients who later developed type 2 diabetes and 70 controls, matched for body-mass index, age, and sex. Cases and controls were taken from the longitudinal study of health in the Pima Indian population. At baseline, the concentration of adiponectin was lower in cases than in controls (p=0.01) and individuals with high concentrations of this protein were less likely to develop type 2 diabetes than those with low concentrations (incidence rate ratio 0.63 [95% CI 0.43-0.92]; p=0.02).
Lindsay
Robert S
RS
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA. rlindsay@mail.nih.gov
Funahashi
Tohru
T
Hanson
Robert L
RL
Matsuzawa
Yuji
Y
Tanaka
Sachiyo
S
Tataranni
P Antonio
PA
Knowler
William C
WC
Krakoff
Jonathan
J
D052242:Adiponectin; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D017677:Age Distribution; D001130:Arizona / Q000453:epidemiology; D001786:Blood Glucose; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007198:Indians, North American; D036341:Intercellular Signaling Peptides and Proteins; D016014:Linear Models; D008297:Male; D011506:Proteins / Q000009:adverse effects / Q000502:physiology*; D017678:Sex Distribution
D052242:Adiponectin; D001786:Blood Glucose; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins