Hereditary pancreatitis in Japan: a review of pancreatitis-associated gene mutations.
Pancreatitis-associated gene mutations have been reported in patients with hereditary pancreatitis and idiopathic pancreatitis in the Caucasian population and involve the cationic trypsinogen gene, the pancreatic secretory trypsin inhibitor gene and the cystic fibrosis transmembrane conductance regulator gene. In the Japanese population, mutational screening analyses of these genes have shown several mutations. The present study reviews previous reports from Japan in order to evaluate the racial specificity of pancreatitis-associated gene mutations.
Nishimori
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First Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783-8505, Japan. nisao@kochi-ms.ac.jp
Onishi
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S
D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009154:Mutation / Q000235:genetics*; D010195:Pancreatitis / Q000453:epidemiology / Q000235:genetics*; D014357:Trypsin; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000235:genetics; D014362:Trypsinogen / Q000235:genetics
C505032:CFTR protein, human; C064831:PRSS2 protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D014359:Trypsin Inhibitor, Kazal Pancreatic; D014362:Trypsinogen; D014357:Trypsin