Hemodynamic changes during neural deactivation in human brain: a positron emission tomography study of crossed cerebellar diaschisis.
The mechanism of crossed cerebellar diaschisis (CCD) is considered to be secondary hypoperfusion due to neural deactivation. To elucidate the hemodynamics during neural deactivation, the hemodynamics of CCD was investigated. The cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF), cerebral metabolic rate of oxygen (CMRO2), and vascular responses to hypercapnia and acetazolamide stress for CCD were measured in 20 patients with cerebrovascular disease by positron emission tomography with H2(15O), C15O, and 15O2. Vascular responses to hypercapnia and acetazolamide stress were almost the same between CCD side and unaffected side of the cerebellum, a finding that supports the idea that the mechanism of CCD is secondary hypoperfusion due to neural deactivation. The degree of decrease in CBF on the CCD side was almost the same as that in CBV, indicating that vascular blood velocity does not change during neural deactivation. The relation between CBF and CBV of the CCD and unaffected sides was CBV = 0.29 CBF0.56. On the CCD side, the degree of deerease in CMRO2 was less than that in CBF, resulting in a significantly increased OEF. The increased OEF along with the decreased CBV on the CCD side might indicate that neural deactivation primarily causes vasoconstriction rather than a reduction of oxygen metabolism.
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Japan. hito@akita-noken.go.jp
Hiroshi
H
Ito
Iwao
I
Kanno
Eku
E
Shimosegawa
Hajime
H
Tamura
Kumiko
K
Okane
Jun
J
Hatazawa
D000086:Acetazolamide; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D001931:Brain Mapping / Q000379:methods; D002245:Carbon Dioxide; D002531:Cerebellum / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005074:Evoked Potentials, Visual; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006935:Hypercapnia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition; D009474:Neurons / Q000000981:diagnostic imaging; D012016:Reference Values; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000379:methods
D002245:Carbon Dioxide; D000086:Acetazolamide