Noninvasive measurement of cerebral bioimpedance for detection of cerebral edema in the neonatal piglet.
The association of sustained cerebral edema with poor neurological outcome following hypoxia-ischaemia in the neonate suggests that measurement of cerebral edema may allow early prediction of outcome in these infants. Direct measurements of cerebral impedance have been widely used in animal studies to monitor cerebral edema, but such invasive measurements are not possible in the human neonate. This study investigated the ability of noninvasive cerebral impedance measurements to detect cerebral edema following hypoxia-ischaemia. One-day-old piglets were anaesthetized, intubated and ventilated. Hypoxia was induced by reducing the inspired oxygen concentration to 4-6% O(2). Noninvasive cerebral bioimpedance was measured using gel electrodes attached to the scalp. Cerebral bioimpedance was also measured directly by insertion of two silver-silver chloride electrodes subdurally. Noninvasive and invasive measurements were made before, during and after hypoxia. Whole body impedance was measured to assess overall fluid movements. Intracranial pressure was measured continuously via a catheter inserted subdurally, as an index of cerebral edema. There was good agreement between noninvasive and invasive measurements of cerebral impedance although externally obtained responses were attenuated. Noninvasive measurements were also well correlated with intracranial pressure. Whole body impedance changes did not account for increases in noninvasively measured cerebral impedance. Results suggest that noninvasive cerebral impedance measurements do reflect intracranial events, and are able to detect cerebral edema following hypoxia-ischaemia in the neonate.
Perinatal Research Centre, The University of Queensland, Royal Women's Hospital, Herston, Queensland 4029, Australia. barbara_lingwood@health.qld.gov.au
Barbara E
BE
Lingwood
Kimble R
KR
Dunster
Paul B
PB
Colditz
Leigh C
LC
Ward
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001929:Brain Edema / Q000175:diagnosis* / Q000209:etiology; D002545:Brain Ischemia / Q000150:complications; D017097:Electric Impedance; D004567:Electrodes, Implanted; D004568:Electrodiagnosis / Q000379:methods*; D000860:Hypoxia / Q000150:complications; D007427:Intracranial Pressure; D013552:Swine