Aminoacyl-tRNA synthetases and aminoacylation of tRNA in the nucleus.
This review is focused on findings concerning the presence of translation apparatus components (aminoacyl-tRNA synthetases, aminoacyl-tRNA, elongation factors) as well as translation itself in the nucleus. A nuclear role of these molecules is unknown. New findings suggest that well-accepted model of spatial segregation of transcription and translation in eukaryotic cell may be oversimplifcation. Nuclear coupling of both these processes show us how exciting and surprising may be the world of the living cell.
Mucha
Piotr
P
University of Gdańsk, Department of Chemistry, Poland. fly@chemik.chem.univ.gda.pl
D021581:Active Transport, Cell Nucleus; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D019913:Nuclear Localization Signals / Q000378:metabolism; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000378:metabolism*; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D019913:Nuclear Localization Signals; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases