Parvovirus B19 and erythroid cells.
Parvovirus B19 is a human erythrovirus, i.e. which induces the death of erythroid progenitors. In such cells, until now only ubiquitous transcription factors have been described to regulate promoter driven gene expression. Their possible interactions with erythroid specific transcription factors merit further investigations. Effectively, the high level of replication of B19 in erythroid cells is not well understood. In addition to apoptosis, necrosis or inhibition of cell growth, the death of B19 infected erythroid progenitors has been never clearly reported as the result of immunological attack: this mecanism will merit further investigations. The interactions with other cell types in vitro remain at present not well defined but many obstacles have been mentioned which counteract B19 expression.
Virologie et UPR CNRS 9051, Hôpital Saint-Louis, AP-HP, 75010 Paris, France.
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Pillet
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Morinet
D016923:Cell Death; D004279:DNA, Viral; D015672:Erythroid Precursor Cells / Q000821:virology*; D015870:Gene Expression; D006801:Humans; D016732:Parvovirus B19, Human / Q000235:genetics / Q000254:growth & development
D004279:DNA, Viral