Further checkpoints in Th1 development.
Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.
Robinson
Douglas S
DS
Allergy and Clinical Immunology and Leukocyte Biology, Faculty of Medicine, Imperial College, SW7 2AK, London, United Kingdom.
O'Garra
Anne
A
D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D018664:Interleukin-12 / Q000502:physiology*; D020382:Interleukin-18 / Q000502:physiology*; D007378:Interleukins / Q000502:physiology*; D015778:Minor Histocompatibility Antigens; D008954:Models, Biological; D018121:Receptors, Cytokine; D018417:Th1 Cells / Q000276:immunology*
C097732:EBI3 protein, human; D006023:Glycoproteins; D020382:Interleukin-18; D007378:Interleukins; C464565:MYDGF protein, human; D015778:Minor Histocompatibility Antigens; D018121:Receptors, Cytokine; D018664:Interleukin-12