[New approaches to prognosis of risk of development of gastropathies induced by nonsteroid anti-inflammatory agents].
A pharmacological test with indomethacin is suggested for predicting the risk of NSAID-induced gastropathy. It is shown that patients with diagnoses of rheumatoid arthritis and osteoarthrosis can be divided into two groups with respect to the indomethacin test--"vulnerable" and "resistant", characterized by a high and low risk of NAIDS-induced gastropathy development, respectively. The proposed index of resistance to this disorder, together with the glutathione redox buffer test index, can be used as reliable criteria for predicting the NSAID-induced gastropathy.
Central Research Laboratory, Kazan State Medical University, ul. Butlerova 49, Kazan, Tatarstan, 420012 Russia.
L E
LE
Ziganshina
A F
AF
Sultanova
V N
VN
Khaziakhmetova
I Kh
IKh
Valeeva
A U
AU
Ziganshin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D051381:Rats; D012306:Risk; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D007213:Indomethacin