Host-pathogen interactions and the pathogenesis of murine Lyme disease.
Lyme disease results from persistent infection with the spirochete Borrelia burgdorferi. A combination of bacterial factors and host factors contributes to the development of inflammatory disease. Studies from the past year have provided insight into both sides of this host-pathogen interplay. We now have a better appreciation of the bacterial genes and products that are involved in pathology and the components of the host response that participate in disease development.
Weis
Janis J
JJ
Division of Cell Biology and Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132-2501, USA. janis.weis@path.utah.edu
D000818:Animals; D001170:Arthritis, Infectious / Q000276:immunology* / Q000382:microbiology; D025065:Borrelia burgdorferi / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D004195:Disease Models, Animal; D007113:Immunity, Innate; D008193:Lyme Disease / Q000276:immunology* / Q000382:microbiology; D051379:Mice