Prognostic value of various staging and grading systems in proximal colon cancer.
OBJECTIVE
To compare the ability of various methods of staging and grading to predict survival in proximal colon cancer.


METHODS
Retrospective study.


METHODS
University hospital, Finland.


METHODS
153 patients with primary proximal colon cancer.


METHODS
Staging by four classification systems, grading by two grading systems, and survival analysis based on Kaplan-Meier survival curves.


RESULTS
In all staging systems the survival curves of different stages differed significantly from each other. The modified Dukes' classification was still the best predictor of survival. Grade of tumours had no significant effect on long term survival, but short term survival was affected adversely by the presence of anaplastic tissue. Tumours with no mucin had a worse prognosis than those that produced mucin. All staging methods were superior to either of the histological grading systems tested as prognosticators. Tumour depth correlated with the operator's clinical impression of radicality of operation, and also predicted survival.


CONCLUSIONS
The clinicopathological modified Dukes' staging system was the most powerful prognosticator in proximal colonic cancer and its use in clinical practice should continue. Even a small amount of anaplastic tissue (> or = 5%) had an adverse effect on short term survival.
Department of Surgery, University of Turku, Finland.
Marja
M
Hilska
Yrjö
Y
Collan
Peter J
PJ
Roberts
Jari
J
Ovaska
Jyrki
J
Kössi
Hannu
H
Paajanen
Matti
M
Laato
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001707:Biopsy, Needle; D003110:Colonic Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005387:Finland; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015996:Survival Rate