The clinical and microbiological effects of a novel acidified sodium chlorite mouthrinse on oral bacterial mucosal infections.
Acidified sodium chlorite mouthrinses have been shown to have equivalent anti-plaque activity to those containing chlorhexidine, the current 'gold standard'. In this study, sodium chlorite mouthrinses (ASC) acidified with either malic or gluconic acids were compared to each other and with a chlorhexidine rinse and sterile water for their effect on salivary bacterial counts. Sixteen subjects participated in the study, which had a cross-over Latin square design. In a second study, a sodium chlorite/gluconic acid rinse was compared with chlorhexidine for its clinical and microbiological effects in 36 patients with oral mucosal infections. The sodium chlorite rinses acidified with malic and gluconic acids and the chlorhexidine rinse caused significant reductions in salivary bacterial counts up to 7 h after a single rinse compared with water. There were no significant differences between the three active treatments. In the mucosal infection study, there was a significant reduction in erythema in the chlorhexidine group compared with the ASC group. Patients who received the ASC rinse reported significantly less discomfort following treatment than those receiving the chlorhexidine rinse. Staphylococcus aureus counts were significantly reduced in the group who received the sodium chlorite rinse. There were no other significant differences between the treatments. ASC appears to be an effective alternative to chlorhexidine mouthrinse.
Division of Oral Medicine and Pathology, Microbiology & Immunology, Guy's King's and St Thomas' Dental Institute, King's College, London, UK.
L
L
Fernandes-Naglik
J
J
Downes
P
P
Shirlaw
R
R
Wilson
S J
SJ
Challacombe
G K
GK
Kemp
W G
WG
Wade
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use*; D001420:Bacteria, Aerobic / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D002710:Chlorhexidine / Q000494:pharmacology / Q000627:therapeutic use; D002712:Chlorides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005942:Gluconates; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D008293:Malates; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000382:microbiology; D009067:Mouthwashes / Q000494:pharmacology / Q000627:therapeutic use*; D012463:Saliva / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013280:Stomatitis / Q000188:drug therapy* / Q000382:microbiology
D000891:Anti-Infective Agents, Local; D002712:Chlorides; D005942:Gluconates; D008293:Malates; D009067:Mouthwashes; C030298:malic acid; D002710:Chlorhexidine; C030691:gluconic acid; C001599:chlorite