Clinical, microbiological, and economic benefit of a change in antibiotic prophylaxis for cardiac surgery.
Vancomycin and rifampicin replaced cephazolin as antibiotic prophylaxis for coronary artery bypass surgery at our institution. Following this intervention, there was a significant decrease (P < .001) in the surgical-site infection rate from 10.5 (95% confidence interval, 8.2 to 13.3) to 4.9 (95% confidence interval, 3.2 to 7.1) infections per 100 procedures. An estimated $576,655 (Australian) was saved between two 12-month periods.
Spelman
Denis
D
Infection Control and Hospital Epidemiology Unit, Alfred Hospital, Prahran, Victoria, Australia.
Harrington
Glenys
G
Russo
Phil
P
Wesselingh
S
S
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000191:economics; D003362:Cost-Benefit Analysis; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage*; D013530:Surgical Wound Infection / Q000191:economics / Q000517:prevention & control*; D014640:Vancomycin / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D012293:Rifampin