Comparative antimicrobial activity of lysosubtilin and its acid-resistant derivative, Fermosorb.
Comparative data are given on the in vitro activity of lysosubtilin against micro-organisms and its acid-resistant derivative, Fermosorb. The lytic activity Fermosorb against all micro-organisms tested was higher (in the range of 0.9-7.7 and 4.1-13.5% for bacteria and filamentous fungi/yeasts, respectively) than that achieved by the action of lytic enzymes present in lysosubtilin solution. All six lysosubtilin-resistant strains tested were Fermosorb-susceptible. Considering the increase in the incidence of antibiotic resistance antimicrobial enzymotherapy or enzymoprophylaxis by means of Fermosorb might be considered for the treatment of intestinal infections in animals.
Sector of Immunomodulators, Institute of Immunology, 29 Molëtø plentas, LT-2021 Vilnius, Lithuania.
Gediminas Arvydas
GA
Biziulevièius
Vilhelmina
V
Sukaitë
D000143:Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000737:chemistry* / Q000201:enzymology; D001419:Bacteria / Q000187:drug effects*; D001433:Bacteriolysis; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013381:Subtilisins / Q000737:chemistry / Q000494:pharmacology*
D000143:Acids; D000900:Anti-Bacterial Agents; C471835:Fermosorb.; D013381:Subtilisins