Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog.
A 12-year-old Cocker Spaniel with an oral malignant melanoma was evaluated for progressive lethargy and anorexia. No metastases were identified during antemortem evaluation, but severe hypercalcemia was evident. Antemortem diagnostic testing failed to identify a cause for the hypercalcemia. No neoplasms other than the melanoma were identified on postmortem examination. Serum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein. Paraneoplastic syndromes are rare in dogs with malignant melanoma.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
Barrak M
BM
Pressler
David S
DS
Rotstein
Jerry M
JM
Law
Thomas J
TJ
Rosol
Bruce
B
LeRoy
Bruce W
BW
Keene
Mark W
MW
Jackson
D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000209:etiology*; D004285:Dogs; D017809:Fatal Outcome; D006934:Hypercalcemia / Q000209:etiology / Q000662:veterinary*; D008297:Male; D008545:Melanoma / Q000150:complications / Q000378:metabolism / Q000662:veterinary*; D009062:Mouth Neoplasms / Q000150:complications / Q000378:metabolism / Q000662:veterinary*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*
D044162:Parathyroid Hormone-Related Protein; D011506:Proteins