Clinical usefulness of assays for complexed prostate-specific antigen.
Tests for the tumor marker prostate-specific antigen (PSA) vary widely in specificity and sensitivity. Use of an assay that tests the complexed form of PSA (cPSA) results in improved specificity and sensitivity. By improving specificity, similar results are obtained by cPSA compared with use of the free-to-total PSA ratio but are measured by a single analyte instead of two. Assays for cPSA can serve as a substitute for total PSA in all current applications.
Brawer
Michael K
MK
Northwest Prostate Institute, 1560 North 115th Street, Suite 209, Seattle, WA 98133, USA. mbrawer@nwhsea.org
D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012016:Reference Values; D012044:Regression Analysis; D012680:Sensitivity and Specificity
D017430:Prostate-Specific Antigen