Quantitative analysis of chiral compounds from unresolved peaks in capillary electrophoresis using multivariate calibration with experimental design and artificial neural networks.
Quantitation of optical isomers can be achieved even from incompletely resolved peaks with a multivariate calibration applying a combination of experimental design and artificial neural networks (ANN). Using the proposed approach, method development can be more efficient and analysis time shortened while quantitation of optical isomers with acceptable precision (+/-1-3%) can be achieved.
Department of Analytical Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
Vlastimil
V
Dohnal
Hua
H
Li
Marta
M
Farková
Josef
J
Havel