A praziquantel-ineffective fascioliasis case successfully treated with triclabendazole.
Human fascioliasis cases in Japan have been reported infrequently and the most appropriate therapy for this disease remains to be determined. This case report describes a patient with the infection unsuccessfully treated with multiple high doses of praziquantel for over 1 year and eventually cured by the administration of triclabendazole in two single doses of 10 mg/kg and 12.5 mg/kg 5 months apart.
Department of Surgery, Niimi Central Hospital, Niimi, Okayama 728-0011, Japan.
Yasunori
Y
Ishii
Fukumi
F
Nakamura-Uchiyama
Yukifumi
Y
Nawa
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D005209:Fasciola / Q000187:drug effects; D005211:Fascioliasis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole; D011223:Praziquantel