Spironolactone for the treatment of hypercalciuric hypocalcemia.
A patient with hypocalcemia and hypomagnesemia, and renal wasting of both cations, is presented. This patient had a dramatic calcium response to treatment with spironolactone. The possible diagnoses and mechanisms of response are discussed. It is concluded that the patient had a calcium-sensing receptor mutation, and that treatment with spironolactone induced an effect on renal handling of calcium in this condition. It is suggested that this treatment be tried in other similar patients.
Division of Endocrinology and Metabolic Medicine, Mubarak Al Kabeer Hospital, Jabriya, Kuwait.
Abeer
A
Al-Gharabally
Suhail A R
SA
Doi
Kamal A S
KA
Al-Shoumer
D002118:Calcium / Q000652:urine*; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000652:urine; D008274:Magnesium / Q000097:blood; D008875:Middle Aged; D013148:Spironolactone / Q000627:therapeutic use*
D004232:Diuretics; D013148:Spironolactone; D008274:Magnesium; D002118:Calcium