Inheriting a structural scaffold for Golgi biosynthesis.
In animal cells, the Golgi complex undergoes reversible disassembly during mitosis. The disassembly/reassembly process has been intensively studied in order to understand the mechanisms that govern organelle assembly and inheritance during cell division. A long-standing controversy in the field has been whether formation of Golgi structure is template-mediated or self-organizes from components of the endoplasmic reticulum. A recent study1 however, has demonstrated that a subset of proteins that form a putative Golgi matrix can be inherited during cell division in the absence of membrane input from the endoplasmic reticulum. The outcome of this study suggests that a templating mechanism for the formation of Golgi structure may exist. This study has important implications for understanding mechanisms that govern Golgi biogenesis.
Jesch
Stephen A
SA
Department of Molecular Biology and Genetics, 245 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA. saj23@cornell.edu
D000818:Animals; D001324:Autoantigens; D020126:Brefeldin A / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000187:drug effects / Q000378:metabolism*; D000077614:Golgi Matrix Proteins; D008565:Membrane Proteins / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology
D001324:Autoantigens; C108705:GORASP1 protein, human; D000077614:Golgi Matrix Proteins; C097741:Golgin subfamily A member 2; D008565:Membrane Proteins; D011500:Protein Synthesis Inhibitors; D020126:Brefeldin A