Alcohol consumption and the risk of diabetes by body mass index levels in a cohort of 5,636 Japanese.
The association between alcohol consumption and the risk of diabetes in Japanese with a low-body mass index (BMI) (< or = 22.0 kg/m(2)), middle-BMI (22.1-24.9 kg/m(2)) and high-BMI (> or =25.0 kg/m(2)) was investigated among a cohort of 5,636 employees of a Japanese insurance company. Participants were free of diabetes at baseline and were followed up for a mean of 5.7 years with annual assessments of fasting plasma glucose (FPG). The outcome was a clinical diagnosis of diabetes on the basis of a questionnaire administered at each follow-up assessment or a follow-up FPG level of 7.8 mmol/l or more. Relative risks and 95% confidence intervals (95% CIs) were estimated by fitting pooled logistic regression models, which included age, gender, BMI, baseline FPG level, current tobacco use and current alcohol consumption. A total of 264 outcome events were recorded. The relative risk of diabetes associated with current alcohol consumption was 3.19 (95% CI 1.09-9.37) among low-BMI individuals, 0.41 (0.23-0.73) among middle-BMI individuals and 0.74 (0.44-1.25) among high-BMI individuals. In this study, current alcohol consumption was associated with an increased risk of diabetes among low-BMI individuals and a decreased risk of diabetes among middle-BMI individuals. A tendency for an association of alcohol consumption with a decreased risk of diabetes among high-BMI individuals was noted, although without statistical significance.
Department of Health Science, Shiga University of Medical Science, Seta-tsukinowa-cho, Otsu-shi, Shiga-ken 520-2192, Japan. makoto@belle.shiga-med.ac.jp
Makoto
M
Watanabe
Federica
F
Barzi
Bruce
B
Neal
Hirotsugu
H
Ueshima
Yuji
Y
Miyoshi
Akira
A
Okayama
Sohel Reza
SR
Choudhury
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D044466:Asian People; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol