Synthesis of (+/-)-aculeatins A and B.
The first synthesis of two new antiprotozoal and natural products was performed using concomitant deprotecting dithiane-phenolic oxidative reactions to form in one-step the 1,7-dioxadispiro[5.1.5.2]pentadecane core.
Wong
Yung-Sing
YS
Laboratoire de Transformations et Synthèse de Substances Naturelles, Faculté de Pharmacie de Reims Champagne-Ardenne, UMR CNRS 6013, 51, rue Cognac-Jay, F-51096 Reims, France. ys.wong@univ-reims.fr
D000473:Alkanes / Q000138:chemical synthesis*; D000981:Antiprotozoal Agents / Q000138:chemical synthesis*; D003512:Cyclohexanones; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000473:Alkanes; D000981:Antiprotozoal Agents; D003512:Cyclohexanones; D013141:Spiro Compounds; C476177:aculeatin A; C476176:aculeatin B