Tales of the cryptic: unveiling more angiogenesis inhibitors.
Over the past few years, there has been a dramatic increase in the identification of anti-angiogenic fragments from larger proteins with unrelated functions. These cryptic anti-angiogenic molecules are largely derived from matrix components such as collagen and fibronectin, as well as from circulating proteins and some intracellular proteins. Here, we discuss the relevance of these developments in terms of their physiological roles and possible therapeutic applications.
D'Amore
Patricia A
PA
Ng
Yin Shan
YS
D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D003094:Collagen / Q000737:chemistry; D006801:Humans; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry; D014369:Tryptophan-tRNA Ligase / Q000737:chemistry / Q000235:genetics
D020533:Angiogenesis Inhibitors; D011994:Recombinant Proteins; D003094:Collagen; D014369:Tryptophan-tRNA Ligase