[Expression and localization of Nogo-A mRNA in rat nerve tissue].
OBJECTIVE
To investigate the expression and localization of Nogo-A mRNA in brain, spinal cord, optic nerve, and sciatic nerve.


METHODS
Frozen sections of brain, spinal cord, optic nerve, and sciatic nerve of 8 rats were made. In situ hybridization was conducted and the sections were observed by light microscopy.


RESULTS
The expression of Nogo-A mRNA was positive in brain, spinal cord, and optic nerve, and negative in sciatic nerve.


CONCLUSIONS
The expression of Nogo-A mRNA is negative in brain, spinal cord, and optic nerve, which may be related to the poor axon regeneration in central nervous system.
Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Jian
J
Ye
Zhengguo
Z
Wang
Peifang
P
Zhu
D000818:Animals; D005260:Female; D015870:Gene Expression; D008297:Male; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism*; D009417:Nerve Tissue / Q000378:metabolism*; D000070798:Nogo Proteins; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603197:Rtn4 protein, rat