Does PTH have a direct effect on intestine?
Dogma for the past three decades has dictated that parathyroid hormone (PTH) has no direct effect on intestine with regard to calcium or phosphate absorption, but rather that PTH acts to promote the synthesis of a hormonally active form of vitamin D, namely 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. However, diverse laboratories have each provided some evidence to suggest PTH does indeed have a direct effect on intestine. We will briefly review the evidence for biological effects, biochemical effects, and the presence of intestinal receptors for PTH, and conclude with the implications for biomedical research.
Nemere
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Department of Nutrition and Food Sciences and the Biotechnology Center Utah State University, Logan, Utah 84322-8700, USA. nemere@cc.usu.edu
Larsson
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D017136:Ion Transport / Q000187:drug effects; D010281:Parathyroid Hormone / Q000378:metabolism* / Q000494:pharmacology; D018016:Receptors, Parathyroid Hormone / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D010281:Parathyroid Hormone; D018016:Receptors, Parathyroid Hormone; D002118:Calcium