[HCV / HIV co-infection: a different perspective].
The clinical significance of HCV-HIV co-infection has notoriously changed due to the introduction of new anti-retroviral therapeutic combinations against HIV infection. Their effectiveness in dramatically reducing AIDS mortality, and the corresponding increase in hospitalization and death related to liver disease. Considerations facing this new reality will have to include epidemiological aspects, pathogenetic interactions, the influence of highly active anti-retroviral therapies (HAART) on the natural history of HCV infection, including their HCV--enhanced liver toxicity, and current new strategies about therapeutic measures against HCV infection in the frame of the most recent advances in HIV therapy.
Hospital Interzonal Gral. San Martín, Servicio de Gastroenterología, Cátedra de Gastroenterología de Posgrado, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina. ajmelnitzky@infovia.com.ar
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Jmelnitzky
D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D011379:Prognosis
D000998:Antiviral Agents