Cytotoxic germacranolides from Inula verbascifolia subsp. methanea.
The aerial parts of Inula verbascifolia subsp. methanea yielded three new epoxygermacranolides, compounds 1-3, in addition to the previously known 9beta-hydroxyparthenolide. The structures of 1-3 have been elucidated on the basis of their spectral data (MS, CD, 1D and 2D NMR) and by quantum mechanical calculations. The in vitro cytotoxic activity of compounds 1-3 was evaluated against six human solid tumor cell lines.
Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis, Zografou, GR-15771, Athens, Greece.
Evagelia
E
Harvala
Nektarios
N
Aligiannis
Alexios-Leandros
AL
Skaltsounis
Haris
H
Pratsinis
George
G
Lambrinidis
Catherine
C
Harvala
Ioanna
I
Chinou
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms; D002855:Chromatography, Thin Layer; D002942:Circular Dichroism; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006115:Greece; D006801:Humans; D038143:Inula / Q000737:chemistry*; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D011471:Prostatic Neoplasms; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
C465903:9-(3-hydroxy-2-methylbutyryloxy)parthenolide; C465901:9-(3-hydroxy-3-methylpentanoyloxy)parthenolide; C465902:9-(3-hydroxyisovaleryloxy)parthenolide; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes