[Dopamine antibodies as neuromodulators of behavioral reactions in mice of different genotypes].
A possibility of the long-term modification of inborn behavioral features of different mice genotypes (C57B1/6 and BALB/c) by active immunization with dopamine-bovine serum albumin conjugate was investigated. Significant interstrain differences were found in the effects of dopamine antibodies on the open-field behavior and the content of neurotransmitters in the brain cortex and striatum. It was shown that the active immunization of mice to dopamine produces an increase in the functional activity of brain dopamine receptors. The extent, to which this increase is pronounced, is genotype-dependent.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
V A
VA
Evseev
O I
OI
Mikovskaia
L A
LA
Vetrilé
N A
NA
Trekova
L A
LA
Basharova
T G
TG
Khlopushina
M A
MA
Gruden'
D000818:Animals; D000906:Antibodies / Q000378:metabolism* / Q000494:pharmacology; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000276:immunology / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000378:metabolism; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism; D014611:Vaccination
D000906:Antibodies; D018492:Dopamine Antagonists; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D012710:Serum Albumin, Bovine; D012701:Serotonin; D013134:Spiperone; D004298:Dopamine