Delivery of insulin from hydroxyapatite ceramic microspheres: preliminary in vivo studies.
The major limiting factor in utilizing protein drugs for sustained delivery is the lack of suitable delivery systems. Ceramic hydroxyapatite microspheres are biocompatible and utilized for the purification of proteins. As a preliminary study, we have investigated the possibility of using hydroxyapatite ceramic microspheres loaded with insulin as an implantable delivery system in rats. With this limited test, it was shown that the loaded insulin was active and able to suppress the blood glucose level in normal rats.
Paul
Willi
W
Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram 695 012, India.
Nesamony
Jerry
J
Sharma
Chandra P
CP
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D006882:Hydroxyapatites / Q000737:chemistry* / Q000378:metabolism; D015918:Infusion Pumps, Implantable; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D007332:Insulin Infusion Systems; D008297:Male; D008863:Microspheres; D051381:Rats
D001672:Biocompatible Materials; D001786:Blood Glucose; D006882:Hydroxyapatites; D007328:Insulin