Simulation for population pharmacodynamic analysis of dose-ranging trials: usefulness of the mixture model analysis for detecting nonresponders.
Pharmacokinetics and Drug Delivery Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan.
Takeshi
T
Shiiki
Yukiya
Y
Hashimoto
Ken-ichi
K
Inui
D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D013678:Technology, Pharmaceutical / Q000379:methods