Choanal atresia: the result of maternal thyrotoxicosis or fetal carbimazole?
We present the fourth published case of a child affected with choanal atresia following maternal treatment with carbimazole. The mother was receiving her highest dose of carbimazole at the crucial period for development of the choanae, between days 35 and 38.
Barwell
Julian
J
Department of Clinical Genetics, Guy's and St. Thomas's Hospital Trust, Guy's Hospital, London, UK. Julian.Barwell@gstt.sthames.nhs.uk
Fox
Grenville F
GF
Round
Jonathan
J
Berg
Jonathan
J
D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects*; D002754:Choanal Atresia / Q000139:chemically induced / Q000209:etiology*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D008831:Microcephaly / Q000139:chemically induced / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D013971:Thyrotoxicosis / Q000188:drug therapy*
D013956:Antithyroid Agents; D002231:Carbimazole