Direct catalytic asymmetric aldol reactions of aldehydes.
The development of a direct catalytic enantioselective aldol reaction of aldehydes with activated carbonyl compounds catalyzed by chiral amines is presented and the potential demonstrated by the synthesis of optically active beta-hydroxycarboxylic acid derivatives.
Center for Metal Catalyzed Reactions, Department of Chemistry, Aarhus University, DK-8000, Aarhus C, Denmark.
Anders
A
Bøgevig
Nagaswamy
N
Kumaragurubaran
Karl Anker
KA
Jørgensen
D000438:Alcohols / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; D000447:Aldehydes; D007659:Ketones