Gastroprotective effect of adrenomedullin administered subcutaneously in the rat.
Subcutaneous injections of adrenomedullin prevented reserpine-induced gastric mucosal damage in a dose-dependent manner (1-1000 ng/kg), but did not interfere with the lesions produced by ethanol administration. In pylorus-ligated rats adrenomedullin significantly reduced gastric volume, total and free acid output as well as ulcer formation. The gastroprotective activity of adrenomedullin was not present in rats pretreated with cysteamine. These results suggest that adrenomedullin exerts its antiulcer effect, when it is administered subcutaneously (s.c.), probably by a mechanism which involves somatostatin related transmission.
Clementi
Giuseppe
G
Department of Experimental and Clinical Pharmacology, School of Medicine, University of Catania, Catania, Italy. gclemen@unict.it
Caruso
Antonina
A
Cutuli
Vincenza Maria Catena
VM
Mangano
Nunzio Guido
NG
Salomone
Salvatore
S
Lempereur
Laurence
L
Prato
Agata
A
Matera
Mario
M
Amico-Roxas
Matilde
M
D053607:Adrenomedullin; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003543:Cysteamine / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000293:injuries; D006863:Hydrogen-Ion Concentration; D008297:Male; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D011708:Pylorus; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000494:pharmacology; D013004:Somatostatin / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D010455:Peptides; D053607:Adrenomedullin; D000431:Ethanol; D013004:Somatostatin; D003543:Cysteamine; D012110:Reserpine