Vaginal disinfection during labour for reducing the risk of mother-to-child transmission of HIV infection.
BACKGROUND
Mother-to-child transmission (MTCT) of HIV infection is one of the most tragic consequences of the HIV epidemic, especially in resource-limited countries, resulting in about 650 000 new paediatric HIV infections each year world-wide. The paediatric HIV epidemic threatens to seriously undermine decade-old child survival programmes. This is one of several reviews assessing the available evidence for preventing HIV transmission from an HIV-infected woman to her child. The other reviews assess the effects of antiretroviral therapy, Caesarean section delivery, breast feeding, and vitamin A supplementation.


OBJECTIVE
To estimate the effect of vaginal lavage on the risk of MTCT of HIV and infant and maternal mortality and morbidity, as well as tolerability of vaginal lavage in HIV infected women.


METHODS
We searched the Cochrane Controlled Trials Register, Cochrane Pregnancy and Childbirth Register, PubMed, EMBASE, AIDSLINE, LILACS, AIDSTRIALS, and AIDSDRUGS, using standardised methodological filters for identifying trials. We also searched reference lists of identified articles, relevant editorials, expert opinions and letters to journal editors, and abstracts and proceedings of relevant conferences, and contacted subject experts and pharmaceutical companies. There were no language restrictions.


METHODS
Randomised trials or clinical trials comparing vaginal disinfection during labour with placebo or no treatment, in known HIV infected pregnant women. Trials had to include an estimate of the effect of vaginal disinfection on MTCT of HIV and/or any other pre-specified adverse pregnancy outcome to be included.


METHODS
Two reviewers independently assessed trial eligibility and quality, and extracted data.


RESULTS
Only one low quality trial included an estimate of the effect of vaginal disinfection on at least one pre-specified outcome. There was no evidence of an effect of vaginal disinfection on MTCT of HIV (odds ratio 0.93, 95% confidence interval 0.63 to 1.38), and no information was available on the other pre-specified outcomes.


CONCLUSIONS
There is a need for well-designed randomised controlled trials to estimate the effects of vaginal disinfection on MTCT of HIV.
Shey
W I
WI
Department of Community Health, Ministry of Public Health, BP 25125 Messa, Yaoundé, Cameroon. wiysonge@yahoo.com
Brocklehurst
P
P
Sterne
J A
JA
D004203:Disinfection / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007743:Labor, Obstetric; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D012306:Risk; D007507:Therapeutic Irrigation; D014621:Vagina / Q000821:virology*