High headache prevalence among women with hemochromatosis: the Nord-Trøndelag health study.
In this large cross-sectional population-based study, 51,272 persons responded to a headache questionnaire and were screened for hemochromatosis. Phenotypic hemochromatosis and the C282Y/C282Y genotype were both associated with an 80% increase in headache prevalence evident only among women. The reason for this association is unclear, but one may speculate that iron overload alters the threshold for triggering a headache by disturbing neuronal function.
Hagen
Knut
K
Department of Clinical Neuroscience, Section of Neurology, Norwegian University of Science and Technology, 7006 Trondheim, Norway. knut.hagen@medisin.ntnu.no
Stovner
Lars Jacob
LJ
Asberg
Arne
A
Thorstensen
Ketil
K
Bjerve
Kristian S
KS
Hveem
Kristian
K
D000328:Adult; D000818:Animals; D003430:Cross-Sectional Studies; D005260:Female; D006261:Headache / Q000453:epidemiology*; D006432:Hemochromatosis / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D009664:Norway / Q000453:epidemiology; D010641:Phenotype; D015995:Prevalence; D011795:Surveys and Questionnaires
D007501:Iron