Immortalization and transformation of human cells.
The disruption of homeostatic mechanisms that regulate normal cell growth and proliferation is a hallmark of cancer. Experimentally, many of the same genetic changes that lead to abnormal cell proliferation conspire to confer replicative immortality upon cells in culture. Correspondingly, several lines of evidence implicate cellular immortalization as a prerequisite for cell transformation. Recently much progress has been made in elucidating the cellular machinery that regulates cell lifespan. This review summarizes these recent advances in our understanding of these molecular mechanisms that contribute to human cell immortalization and transformation.
Hahn
William C
WC
Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. William_Hahn@dfci.harvard.edu
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D019098:Telomerase / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; D025521:Tumor Suppressor Proteins; D019098:Telomerase