[Effect of prenatal hyperandrogenism during pregnancy and on postnatal development of rats].
Hyperandrogenia was modelled in the female rats within the whole term of pregnancy by means of testosterone or dihydrotestosterone. Both androgens have been established to induce significant prenatal mortality and high percentage of mortinatus and postnatal mortality of progeny. Hyperandrogenization influenced negatively the sexual development and reproductive function of the female progeny versus the male one.
Klimova
O P
OP
V. Danilevsky Institute of Endocrine Pathology Problems, Kharkiv.
D000728:Androgens / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D013196:Dihydrotestosterone / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D017588:Hyperandrogenism / Q000150:complications*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D012741:Sexual Maturation / Q000187:drug effects; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology
D000728:Androgens; D013196:Dihydrotestosterone; D013739:Testosterone