NMR in drug discovery.
NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-like inhibitors for use as lead compounds in drug discovery.
Pellecchia
Maurizio
M
TRIAD Therapeutics, Inc., 9381 Judicial Drive, San Diego, California 92121, USA.
Sem
Daniel S
DS
Wüthrich
Kurt
K
D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry
D004364:Pharmaceutical Preparations; D011506:Proteins