The effects of amlodipine on cerebral circulatory values in patients with essential hypertension.
OBJECTIVE
This study assessed the effects of calcium channel blocker Amlodipine on the cerebral circulation in patients with essential hypertension.


METHODS
Cerebral circulation in 37 patients with essential hypertension and 10 healthy subjects was assessed using rheoplethysmography. In patients with essential hypertension cerebral circulation values were also re-estimated after treatment with Amlodipine (5-10 mg daily).


RESULTS
The cerebral circulatory parameters in hypertensive patients before treatment with Amlodipine were different from those in healthy persons. Amlodipine along with the reduction in systemic blood pressure caused attenuation of cerebrovascular abnormalities: decrease in spastic signs and increase in cerebral blood supply in patients with essential hypertension.


CONCLUSIONS
Amlodipine causes reduction of cerebral vascular resistance and promotes improvement in arterial blood filling in patients with essential hypertension. These changes in cerebral circulation may be secondary to the increase of cardiac output--known effect of Amlodipine.
Department of Cardiology, Hospital of Ministry of Internal Affairs, Baku, Azerbaijan.
I G
IG
Alizade
N T
NT
Karayeva
D000328:Adult; D017311:Amlodipine / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D016022:Case-Control Studies; D002536:Cerebral Arteries / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D016896:Treatment Outcome
D002121:Calcium Channel Blockers; D017311:Amlodipine