The Relationship between Yeast Coexpressed Gene Clusters and Their Upstream cis-acting Elements.
DNA microarrays bring biology a new approach to study functions of genes and genomes from their expression pattern on a genomic scale. With its fully sequenced genome and newly published expression patterns available, budding yeast (Saccharomyces cerevisiae) was chosen to carry out an investigation of the relationship between gene 5' upstream cis-acting elements and expression patterns using bioinformatic tools. Results show that genes in the same cluster share common cis-acting element candidates and can be regulated by same transfactors. In the sites found by this study, some sites are corresponding to known cis-acting elements, while others may indicate new ones that can be tested by experiments. The results are helpful to understand more about gene functions, metabolic pathways and genetic networks.
Xie
Tao
T
Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. dingdafu@server.shcnc.ac.cn
Sheng
Quan-Hu
QH
Ding
Da-Fu
DF