cDNA microarray analysis of global gene expression in sarcomas.
Sequencing of the human genome and rapidly evolving microarray technology have combined to provide investigators with the ability to analyze individual tumors and groups of tumors for global patterns of gene expression. Few of these types of studies have been performed on rhabdomyosarcomas and osteogenic sarcomas, including cell lines and animal models. Groups of expressed genes that may characterize rhabdomyosarcomas and their subgroups and separate them from other types of tumors have been identified. More specifically, genes involved in myogenesis or the inhibition of myogenesis have been identified, as have genes that may play a role in metastatic activity in osteogenic sarcomas. Also, a study documenting the consistent and specific gene expression profile of gastrointestinal stromal tumors has been published. While the data regarding gene expression patterns in sarcomas is accruing, numerous investigators are working on developing and enhancing bioinformatic skills and tools such that the vast amount of data can be converted into knowledge regarding biology, therapeutic responsiveness or resistance, and prognosis.
Schofield
Deborah
D
Department of Pathology, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Triche
Timothy J
TJ
D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D006801:Humans; D009124:Muscle Proteins / Q000096:biosynthesis; D020411:Oligonucleotide Array Sequence Analysis; D012516:Osteosarcoma / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D012509:Sarcoma / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology
D005819:Genetic Markers; D009124:Muscle Proteins