[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy].
OBJECTIVE
To investigate the relationship of gene polymorphism of angiotension converting enzyme (ACE), aldosterone synthase (CYP11B2) with essential hypertension (EH) and left ventricular hypertrophy (LVH) in hypertensive patients.


METHODS
(1) Left ventricular mass and geometry were assessed with ECG and echocardiography in 136 hypertensive patients. (2) The insertion/deletion polymorphism of ACE gene and the -344C/T polymorphism of CYP11B2 gene were monitored by polymerase chain reaction (PCR).


RESULTS
(1) ACE and CYP11B2 gene showed significant difference in genotype or allele frequency distribution in the group with LVH as compared with the group without (P < 0.05). (2) There was a significant difference in CT + II combined genotype frequency distribution in the group with LVH as compared with the group without (P < 0.05).


CONCLUSIONS
(1) No relationship between the polymorphism of CYP11B2 gene and ACE gene with essential hyptension could be found. (2) A significant relationship between the polymorphism of ACE and CYP11B2 gene with LVH in EH could be found. I allele of ACE gene and C allele of CYP11B2 gene may be independent risk factors for LVH in hypertensive patients. (3) There is a synergistic effect between the polymorphism of ACE gene and CYP11B2 gene to result in LVH in EH.
Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. chenaha@21.cn.com
Aihua
A
Chen
Wenxiu
W
Zhang
Xiaoming
X
Tang
Zhiliang
Z
Li
Qing
Q
Lu
Xuexian
X
Qian
D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D019405:Cytochrome P-450 CYP11B2; D007703:Peptidyl-Dipeptidase A