Non-canonical Wnt signalling and regulation of gastrulation movements.
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.
Tada
Masazumi
M
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. m.tada@ucl.ac.uk
Concha
Miguel L
ML
Heisenberg
Carl Philipp
CP
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005775:Gastrula / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism; D008024:Ligands; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins; D014981:Xenopus / Q000196:embryology*; D029867:Xenopus Proteins; D015027:Zebrafish / Q000196:embryology*; D029961:Zebrafish Proteins
D006023:Glycoproteins; D008024:Ligands; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; C092568:Wnt11 protein, zebrafish; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; C512785:wnt11b protein, Xenopus; C094522:wnt8b protein, zebrafish; D002118:Calcium