Ultrastructural features and ICSI treatment of severe teratozoospermia: report of two human cases of globozoospermia.
Abnormal sperm morphology is associated with male infertility. We describe two human cases of globozoospermia (round-headed spermatozoa) together with fine diagnosis and proposed treatment. Scanning and transmission electron microscopy (SEM and TEM) were performed to identify the ultrastructural features. Female partners underwent ovarian hyperstimulation and intracytoplasmic sperm injection (ICSI). Fertilized oocytes were transferred 36 h later. One couple had a healthy live-birth. Ultrastructural analysis may help to diagnose sperm morphology and identify those which will respond to treatment.
Department of Obstetrics and Gynaecology and Radiological Sciences, Centre for Reproductive Medicine and Infertility, Ascoli-Tomaselli Hospital, University of Catania, Catania 95125, Italy.
Luciano G
LG
Nardo
Fulvia
F
Sinatra
Giovanni
G
Bartoloni
Salvatore
S
Zafarana
Filadelfo
F
Nardo
D000328:Adult; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009845:Oligospermia / Q000473:pathology* / Q000628:therapy*; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000473:pathology* / Q000648:ultrastructure*