[Comparative study of the anti-arrhythmic activity of cardiocyclide and nibentan in hypersympathotonia and acute myocardial ischemia].
The antiarrhythmogenic and antifibrillar action of cardiocyclide and nibentan--class III antiarrhythmogens (according to the classification of Vaughan Williams) was experimentally studied on narcotized cats. The hypersympathotonia model was induced by a 30-sec stimulation of the left stellate cervical ganglion on the background of acute myocardial infarction. On this model of a ventricular disorder in the heart rhythm, cardiocyclide (2.4 mg/kg) and nibentan (0.2 mg/kg) exhibited pronounced antiarrhythmic activity. It is suggested that both drugs can be used under clinical conditions for the prophylaxis of sudden coronary death in patents with acute myocardial infarction.
Vititnova
M B
MB
Laboratory of Circulation System Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Kryzhanovskiĭ
S A
SA
Kaverina
N V
NV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000503:physiopathology*; D001549:Benzamides / Q000627:therapeutic use*; D002415:Cats; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology*; D013233:Stellate Ganglion
D000889:Anti-Arrhythmia Agents; D001549:Benzamides; C105049:nibentan