[Role of superoxide dismutase in maintaining cellular homeostasis upon exposure to gamma-rays and nickel sulfate].
It was shown that the inhibition of one of the main enzymes of antioxidant system--superoxide dismutasw (SOD)--increased the level of damage in gamma-irradiated and NiSO4-treated human cells. The viability of cells pretreated with inhibitor of SOD (TRIEN) decreased in the experiments with gamma-radiation and with NiSO4. DNA repair and replication involved in cell homeostasis also were suppressed in the cells with inhibited SOD. These data are served as proof of participation of SOD in the defence of human cells against oxidative radicals.
Iakovleva
M N
MN
Polar Geophysical Institute, Kola Science Centre, Russian Academy of Sciences, Apatity, 184200 Russia.
Sinel'shchikova
T A
TA
Perminova
I N
IN
Zasukhina
G D
GD
D002478:Cells, Cultured; D004260:DNA Repair; D004261:DNA Replication; D005720:Gamma Rays; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D009532:Nickel / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000502:physiology*
C029938:nickel sulfate; D009532:Nickel; D013482:Superoxide Dismutase