Taking ACE inhibitors during pregnancy. Is it safe?
OBJECTIVE
A pregnant patient is taking enalapril for primary hypertension. How safe are angiotension-converting enzyme inhibitors (ACEI) during pregnancy?


CONCLUSIONS
Evidence of whether ACEIs cause problems during the first trimester of pregnancy is reassuring. There is evidence that they cause severe renal and other problems during the second and third trimesters, however. These drugs should be avoided during pregnancy.
Hospital for Sick Children, Toronto, Ont.
Savithiri
S
Ratnapalan
Gideon
G
Koren
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000818:Animals; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011264:Pregnancy Trimesters
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril