Ion channels: recent progress and prospects.
Determination of the crystal structure of the KcsA potassium channel and its subsequent refinement at 2 A resolution have stimulated much interest in modelling of ion channels. Here we review the recent developments in ion channels research, focusing especially on the question of structure-function relationships, and discuss how permeation models based on Brownian and molecular dynamics simulations can be used fruitfully in this endeavour.
Chung
Shin-Ho
SH
Department of Theoretical Physics, Research School of Physical Sciences, Australian National University, Canberra, ACT 0200, Australia. shin-ho.chung@anu.edu.au
Kuyucak
Serdar
S
D015220:Calcium Channels / Q000737:chemistry*; D003198:Computer Simulation; D003460:Crystallization; D018360:Crystallography, X-Ray; D004058:Diffusion; D007473:Ion Channels / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D015221:Potassium Channels / Q000737:chemistry*; D013329:Structure-Activity Relationship
D015220:Calcium Channels; D007473:Ion Channels; D015221:Potassium Channels