Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man.
Trait dissociation might influence the response to panicogens in normal controls. The behavioral effects of 25 microg of cholecystokinin tetrapeptide (CCK-4) were studied in 18 healthy men, nine each with high or low trait dissociation. Subjects with high trait dissociation showed a significantly lower increase of acute dissociative, anxiety and panic symptoms compared with subjects with low trait dissociation. Trait dissociation should be assessed in further behavioral challenge studies as a potentially important covariate.
Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany. kellner@uke.uni-hamburg.de
Michael
M
Kellner
Alexander
A
Yassouridis
Yun
Y
Hua
Mona
M
Wendrich
Dieter
D
Naber
Klaus
K
Wiedemann
D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis*; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006304:Health Status; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000139:chemically induced* / Q000175:diagnosis; D012720:Severity of Illness Index; D013758:Tetragastrin / Q000009:adverse effects*
D005765:Gastrointestinal Agents; D013758:Tetragastrin