Marchiafava-Bignami disease: cranial MRI and SPECT findings.
Marchiafava-Bignami disease (MBD) associated with chronic alcoholism is a fatal disorder characterized by demyelination of the corpus callosum. It is diagnosed by the imaging of demyelination at the corpus callosum with MRI. This lesion is not only limited to the corpus callosum but also affects the cortico-cortical and cortico-subcortical projections due to disconnection and causes frontal lobe syndromes and dementia. In this article, we presented a case that MBD associated with chronic alcoholism.
Department of Neurology, Trakya University School of Medicine, Edirne 22030, Turkey. celikyahyatr@yahoo.com
Yahya
Y
Celik
Meryem
M
Kaya
Semra
S
Sengün
Ufuk
U
Utku
D000437:Alcoholism / Q000150:complications*; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon