Re-revision of the stereo structure of piperidine lactone, an intermediate in the synthesis of febrifugine.
The stereo structure of piperidine lactone (3), an intermediate of the antimalarial agent febrifugine ((+)-1) prepared by a synthetic method, was re-revised to the cis-form from the trans-form.
Faculty of Pharmaceutical Sciences, Okayama University, Japan. take@pharm.okayama-u.ac.jp
Yasuo
Y
Takeuchi
Kumiko
K
Azuma
Hitoshi
H
Abe
Kenji
K
Sasaki
Takashi
T
Harayama
D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010880:Piperidines / Q000138:chemical synthesis*; D011799:Quinazolines / Q000138:chemical synthesis*
D000962:Antimalarials; D007202:Indicators and Reagents; D007783:Lactones; D010880:Piperidines; D011799:Quinazolines; C470120:piperidine lactone; C001207:febrifugine