Encoding microcarriers: present and future technologies.
In answer to the ever-increasing need to carry out many assays simultaneously in drug screening and drug discovery, several microcarrier-based multiplex technologies have arisen in the past few years. The compounds to be screened are attached to the surface of microcarriers, which can be mixed together in a vessel that contains the target analyte. Each microcarrier has to be encoded to know which compound is attached to its surface. In this article, the methods that have been developed for the encoding of microcarriers are reviewed and discussed.
Braeckmans
Kevin
K
Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
De Smedt
Stefaan C
SC
Leblans
Marc
M
Pauwels
Rudi
R
Demeester
Joseph
J
D001681:Biological Assay; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical; D005336:Fiber Optic Technology; D008863:Microspheres