Autoantibodies to NOR 90/hUBF: longterm clinical and serological followup in a patient with limited systemic sclerosis suggests an antigen driven immune response.
We describe the clinical and serological followup of a 9-year-old girl with anti-nucleolar organizing region 90/human upstream-binding factor (anti-NOR 90/hUBF) who had features of systemic sclerosis over a period of 17 years, from childhood into adulthood. We review the associations of anti-UBF autoantibodies, and provide evidence that anti-NOR 90/UBF immune response is antigen driven.
Dagher
Jehan H
JH
Division of Rheumatology, Hĵpital Notre-Dame, Centre Hospitalier de l'Université de Montréal, Quebec, Canada.
Scheer
Ulrich
U
Voit
Renate
R
Grummt
Ingrid
I
Lonzetti
Lilian
L
Raymond
Yves
Y
Senécal
Jean-Luc
JL
D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000032:analysis*; D002648:Child; D018450:Disease Progression; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D015151:Immunoblotting; D008991:Monitoring, Physiologic; D009697:Nucleolus Organizer Region / Q000276:immunology*; D035463:Pol1 Transcription Initiation Complex Proteins / Q000032:analysis / Q000276:immunology*; D011379:Prognosis; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000276:immunology*; D012698:Serologic Tests / Q000379:methods; D012720:Severity of Illness Index; D013997:Time Factors
D001323:Autoantibodies; D001324:Autoantigens; D035463:Pol1 Transcription Initiation Complex Proteins; C063844:transcription factor UBF