Melatonin and the wintering strategy of the tundra vole, Microtus oeconomus.
Short photoperiod induces physiological changes connected to the wintering of the tundra vole, Microtus oeconomus. The aim of the present study was to investigate the effects of continuous melatonin treatment on selected hormones and enzyme activities associated with energy metabolism in the species. Liver, kidney, and muscle glycogen concentrations and glycogen phosphorylase activities, as well as liver and kidney glucose-6-phosphatase and lipase esterase activities were determined. Plasma leptin, ghrelin, thyroxine, testosterone, cortisol, and melatonin concentrations were also measured. Exogenous melatonin stimulated gluconeogenesis, increased glycogen stores, and reduced fat mobilization in kidneys. Melatonin treatment also increased the food intake of the voles. This may have been mediated via elevated ghrelin levels of the melatonin-treated animals, as ghrelin is known to increase appetite of rodents. Winter metabolism of the species does not seem to require accumulation of fat or extra stores of liver or muscle glycogen. On the contrary, successful wintering of the tundra vole presumably depends on continuous food availability.
Mustonen
Anne-Mari
AM
Department of Biology, University of Joensuu, P.O. Box 111, FIN-80101 Joensuu, Finland. ammusto@cc.joensuu.fi
Nieminen
Petteri
P
Hyvärinen
Heikki
H
D000222:Adaptation, Physiological; D000818:Animals; D003411:Arvicolinae / Q000502:physiology*; D001522:Behavior, Animal; D003080:Cold Temperature; D005260:Female; D006003:Glycogen / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000502:physiology; D008297:Male; D008550:Melatonin / Q000494:pharmacology / Q000502:physiology*; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D012621:Seasons
D006003:Glycogen; D008550:Melatonin