Treasure hunting in a new era: genotyping of single nucleotide polymorphisms and the search for complex disease genes by association scans.
Genotyping single nucleotide polymorphisms by technologies like those described in this issue are propelling us towards a new era in the study of human genetics. This new era promises improved prospects for mapping genes responsible for complex human diseases and other complex traits. In this article, I sketch empirical results and statistical theory that together form the scientific rationale for anticipating enhanced success in gene mapping in the new era that is now approaching.
Ralph
R
McGinnis
D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005821:Genetic Techniques / Q000639:trends*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide