The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.
A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.
Abbott Laboratories, Infectious Disease Research, Department 47N, Abbott Park, IL 60064, USA. richard.sciotti@pfizer.com
Richard J
RJ
Sciotti
Marina
M
Pliushchev
Paul E
PE
Wiedeman
Darlene
D
Balli
Robert
R
Flamm
Angela M
AM
Nilius
Kennan
K
Marsh
DeAnne
D
Stolarik
Robert
R
Jolly
Roger
R
Ulrich
Stevan W
SW
Djuric
D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000069349:Linezolid; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid