T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study.
BACKGROUND
We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP).


METHODS
We recruited 802 subjects in a rural Japanese community who were aged >40 years and who gave written informed consent for monitoring of their ambulatory BP and genetic analysis (the Ohasama Study). As a polymorphism of AGT, T+31C, which is in complete linkage disequilibrium with M235T, was determined using the TaqMan polymerase chain reaction method.


RESULTS
The genotype distribution of AGT/T-+31C in the Ohasama Study was similar to that in another large Japanese population. Although there was no significant difference in 24-h and daytime ambulatory BP values, the nighttime BP was significantly lower in the subjects with TT, resulting in greater decline of nocturnal systolic (P = .090) and diastolic (P = .025) BP in subjects with TT.


CONCLUSIONS
AGT/T+31C is associated with the circadian BP variation but not with BP level in the Japanese general population.
Fujiwara
Tohru
T
Department of Clinical Pharmacology, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan.
Katsuya
Tomohiro
T
Matsubara
Mitsunobu
M
Mikami
Tadayoshi
T
Ishikawa
Kazuhiko
K
Kikuya
Masahiro
M
Ohkubo
Takayoshi
T
Hozawa
Atsushi
A
Michimata
Mari
M
Suzuki
Michiko
M
Metoki
Hirohito
H
Asayama
Kei
K
Araki
Tsutomu
T
Tsuji
Ichiro
I
Higaki
Jitsuo
J
Satoh
Hiroshi
H
Hisamichi
Shigeru
S
Ogihara
Toshio
T
Imai
Yutaka
Y
D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence
D000808:Angiotensinogen