Molecular complexity of vertebrate tight junctions (Review).
Separation of distinct body, organ and tissue compartments, and maintenance of epithelial cell polarity require tight junctions (TJ)-cell-cell junctions located in the apicolateral regions of epithelial and endothelial cells. Studies on the protein components of vertebrate TJ have revealed an intricate network of membrane, sub-membrane, cytoskeletal, and signalling molecules. How these molecules functionally interact to provide TJ with their functions, and what roles these molecules play in control of cell growth and differentiation is a fundamental problem in cell biology.
Department of Molecular Biology, University of Geneva, Switzerland.
Fabio
F
D'Atri
Sandra
S
Citi
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D051528:Guanylate Kinases; D047908:Intracellular Signaling Peptides and Proteins; D062726:Junctional Adhesion Molecules; D016547:Kinesins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D015778:Minor Histocompatibility Antigens; D009218:Myosins / Q000378:metabolism; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D019108:Tight Junctions / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D000076204:WNK Lysine-Deficient Protein Kinase 1
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; C568773:Clmp protein, rat; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D047908:Intracellular Signaling Peptides and Proteins; D062726:Junctional Adhesion Molecules; D008565:Membrane Proteins; D015778:Minor Histocompatibility Antigens; C491749:Mpdz protein, rat; D011506:Proteins; D011991:Receptors, Virus; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C490658:afd-1 protein, C elegans; C512642:par-6 protein, C elegans; C097238:PAR-3 protein, C elegans; D017346:Protein Serine-Threonine Kinases; D000076204:WNK Lysine-Deficient Protein Kinase 1; C410410:Wnk1 protein, rat; C115015:PKC-3 protein; D011493:Protein Kinase C; D009703:Nucleoside-Phosphate Kinase; D051528:Guanylate Kinases; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; D009218:Myosins; D016547:Kinesins