Method of bioindication for evaluation of the effects of plant extracts on cell monolayer in acute and chronic experiments.
Acute and chronic toxicities of plant extracts for external use were studied on a model of cell monolayer. This method detects the toxic dose of the agent during the first stage of the study; the activity of this dose and severity of damaging effect can be further studied on experimental animals. An advantage of the method is high informative value of preliminary investigation in the development of new low-toxic agents.
Seregina
M V
MV
V. V. Karavaev Foundation, Moscow.
Mikhailova
L P
LP
D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*
D010936:Plant Extracts