Orientia tsutsugamushi inhibits apoptosis of macrophages by retarding intracellular calcium release.
Orientia tsutsugamushi shows both pro- and antiapoptotic activities in infected vertebrate cells. Apoptosis of THP-1 cells induced by beauvericin was inhibited by O. tsutsugamushi infection. Beauvericin-induced calcium redistribution was significantly reduced and retarded in cells infected with O. tsutsugamushi. Antiapoptotic activities of O. tsutsugamushi in infected cells are most probably due to inhibition of the increase in the cytosolic calcium concentration.
Department of Microbiology, Inha University College of Medicine, Inchon 400-103, Republic of Korea.
Mee-Kyung
MK
Kim
Seung-Yong
SY
Seong
Ju-Young
JY
Seoh
Tae-Hee
TH
Han
Hyeon-Je
HJ
Song
Ji-Eun
JE
Lee
Jung-Hoon
JH
Shin
Byung-Uk
BU
Lim
Jae-Seung
JS
Kang
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D047630:Depsipeptides; D006801:Humans; D007424:Intracellular Fluid; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D012285:Orientia tsutsugamushi / Q000502:physiology*; D010455:Peptides
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010455:Peptides; C004456:beauvericin; D002118:Calcium