Dyspepsia, non-ulcer dyspepsia, and Helicobacter pylori.
Since the discovery of Helicobacter pylori and its role in peptic ulcer disease, two strategies for low-cost treatment of uninvestigated dyspepsia have emerged: "test and treat" and "test and scope." The efficacy of these strategies is examined, with a review of several recent studies. Controversy exists as to the usefulness of eradication of H. pylori in the treatment of non-ulcer dyspepsia. Results of four large trials are presented as an illustration of this controversy. Guidelines for the management of dyspepsia and non-ulcer dyspepsia are reviewed.
Vakil
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University of Wisconsin Medical School, Milwaukee, WI, USA.
D004415:Dyspepsia / Q000209:etiology / Q000628:therapy; D016481:Helicobacter Infections / Q000628:therapy; D016480:Helicobacter pylori; D006801:Humans; D016032:Randomized Controlled Trials as Topic