Cloning and expression of Xenopus Prickle, an orthologue of a Drosophila planar cell polarity gene.
We have cloned Xenopus orthologues of the Drosophila planar cell polarity (PCP) gene Prickle. Xenopus Prickle (XPk) is expressed in tissues at the dorsal midline during gastrulation and early neurulation. XPk is later expressed in a segmental pattern in the presomitic mesoderm and then in recently formed somites. XPk is also expressed in the tailbud, pronephric duct, retina, and the otic vesicle. The complex expression pattern of XPk suggests that PCP signaling is used in a diverse array of developmental processes in vertebrate embryos.
Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, 94720-3204, USA.
John B
JB
Wallingford
Toshiyasu
T
Goto
Ray
R
Keller
Richard M
RM
Harland
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016764:Cell Polarity / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics; D017344:Genes, Insect; D017403:In Situ Hybridization; D060588:LIM Domain Proteins; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014981:Xenopus / Q000196:embryology* / Q000235:genetics*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D060588:LIM Domain Proteins; C121600:pk protein, Drosophila; D004247:DNA