Intramedullary spindle cell hemangioendothelioma of the thoracic spinal cord--case report.
A 28-year-old Malay man presented with progressive paraparesis over a period of 6 months. Magnetic resonance imaging of the spine revealed a thoracic intramedullary spinal cord tumor at the T-7 level with homogeneous enhancement following intravenous gadolinium administration. Laminectomy and partial decompression of the tumor was performed. Histological examination of the tumor revealed features of spindle cell hemangioendothelioma. The patient was managed with limited field radiotherapy followed by systemic interferon therapy. Good neurological improvement was seen subsequently. The patient has survived 48 months with growth restraint at the primary site, although residual neurological deficit persists. Immunotherapy should be considered as a treatment modality for intramedullary hemangioendothelioma of the spinal cord after surgery and radiotherapy.
Department of Neuroscience, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. neurosurgeryhusm@yahoo.com
Jafri Malin
JM
Abdullah
Samerendra Singh
SS
Mutum
Noor Azam
NA
Nasuha
Biswa Mohan
BM
Biswal
Abdul Rahman Mohd
AR
Ariff
D000328:Adult; D003131:Combined Modality Therapy; D019299:Decompression, Surgical; D006394:Hemangiosarcoma / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007796:Laminectomy; D008279:Magnetic Resonance Imaging; D008297:Male; D020335:Paraparesis / Q000209:etiology*; D011882:Radiotherapy, High-Energy; D011994:Recombinant Proteins; D013117:Spinal Cord Compression / Q000209:etiology; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013904:Thoracic Vertebrae
D007155:Immunologic Factors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins