Identification of a new HLA-B allele, B*3705 containing a Bw6 sequence motif.
HLA-B37, which is Bw4 type antigen frequently found in linkage disequilibrium with A1, Cw6 and DR10 in all ethnic groups, generally has a very low frequency all over the world. We report a new HLA-B*37 allele, B*3705, identified in two potential bone marrow donors in the Korean population. B*3705, which has the Bw6 nucleotide segment, differs from B*3701 in three nucleotide positions: 311, 317 and 319 in exon2. The serological profile of B*3705 did not exhibit the B37 specificity. The putative haplotype associated with B*3705 in the Korean population could be A*02-Cw*0602-DRB1*1001-DQA1*0101-DQB1*0501-DPB1*02011.
Pyo
C-W
CW
Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Han
H
H
Kim
T-G
TG
D000595:Amino Acid Sequence; D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D059912:HLA-B37 Antigen; D006801:Humans; D008969:Molecular Sequence Data
D015235:HLA-B Antigens; C471440:HLA-B*37:05 antigen; D059912:HLA-B37 Antigen; C038652:HLA-Bw6 antigen