A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings.
The silicone elastomer solubilities of a range of drugs and pharmaceutical excipients employed in the development of silicone intravaginal drug delivery rings (polyethylene glycols, norethisterone acetate, estradiol, triclosan, oleyl alcohol, oxybutynin) have been determined using dynamic mechanical analysis. The method involves measuring the concentration-dependent decrease in the storage modulus associated with the melting of the incorporated drug/excipient, and extrapolation to zero change in storage modulus. The study also demonstrates the effect of drug/excipient concentrations on the mechanical stiffness of the silicone devices it 37 degrees C.
Malcolm
R Karl
RK
School of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, Northern Ireland, UK. k.malcolm@qub.ac.uk
McCullagh
Stephen
S
Woolfson
A David
AD
Catney
Martin
M
Tallon
Paul
P
D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D003271:Contraceptive Agents, Female / Q000008:administration & dosage; D003274:Contraceptive Devices, Female; D016503:Drug Delivery Systems; D015914:Estrogen Replacement Therapy; D005079:Excipients; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D012826:Silicone Elastomers; D012995:Solubility
D001672:Biocompatible Materials; D003271:Contraceptive Agents, Female; D005079:Excipients; D012826:Silicone Elastomers