Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset.
This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to or clinical presentation of type 1 diabetes. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 128 Japanese patients with type 1 diabetes and in 107 healthy control subjects in a case-controlled study. The allelic and haplotypic frequencies of the IL-10 gene promoter region polymorphisms were similar in patients with type 1 diabetes and in control subjects. However, the -819T and -592A allele were associated with adult-onset (>18 years) of the disease (p = 0.037). Furthermore, the frequency of ATA haplotype was increased in adult-onset patients than that in early-onset patients (< or =18 years; p = 0.037). Among the genotypes comprising ATA haplotype, the frequency of ATA/ATA was significantly higher in adult-onset patients than in early-onset patients (p = 0.004). These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes.
From the First Department of Internal Medicine, Nagasaki, Japan.
Akane
A
Ide
Eiji
E
Kawasaki
Norio
N
Abiru
Fuyan
F
Sun
Ryoko
R
Takahashi
Hironaga
H
Kuwahara
Naruhiro
N
Fujita
Atsushi
A
Kita
Katsuya
K
Oshima
Hiroyuki
H
Sakamaki
Shigeo
S
Uotani
Hironori
H
Yamasaki
Yoshihiko
Y
Yamaguchi
Katsumi
K
Eguchi
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D001323:Autoantibodies / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D001323:Autoantibodies; D016753:Interleukin-10; D005968:Glutamate Decarboxylase