Association study between iron-related genes polymorphisms and Parkinson's disease.
We have conducted a case-control study in order to test for an association between 8 intragenic polymorphisms of 5 iron-related genes (transferrin, transferrin receptor1, HFE, frataxin and lactoferrin) and Parkinson disease. Comparison of genotypes and allele frequencies did not differ significantly between cases and controls for all studied polymorphisms except the G258S transferrin polymorphism, for which a higher frequency of the G allele was found among cases (p=0.033), particularly among cases with onset older than 60 (p=0.0017) and with negative family history (p=0.022). This finding suggests that genetic variations in the control of iron metabolism may contribute to the pathogenesis of the disease.
INSERM U409, association Claude Bernard, Faculté de Médecine Bichat, B. P. 416, 75 870 Paris cedex 18, Paris.
Claire
C
Borie
Francesca
F
Gasparini
Patrice
P
Verpillat
Anne-Marie
AM
Bonnet
Yves
Y
Agid
Gilles
G
Hetet
Alexis
A
Brice
Alexandra
A
Dürr
Bernard
B
Grandchamp
D017668:Age of Onset; D000368:Aged; D016022:Case-Control Studies; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014168:Transferrin / Q000235:genetics*
D017931:DNA Primers; D014168:Transferrin; D007501:Iron