Mismatch repair defects as a cause of resistance to cytotoxic drugs.
In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.
Paediatric Oncology Research Unit, Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. j.a.e.irving@ncl.ac.uk
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D020137:Base Pair Mismatch; D004260:DNA Repair; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D010641:Phenotype