Reduced arginine availability and nitric oxide production.
The precursor for nitric oxide (NO) synthesis is the amino acid arginine. Reduced arginine availability may limit NO production. Arginine availability for NO synthesis may be regulated by de novo arginine production from citrulline, arginine transport across the cell membrane, and arginine breakdown by arginase.
Hallemeesch
M M
MM
Department of Clinical Chemistry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
Lamers
W H
WH
Deutz
N E P
NE
D026905:Amino Acid Transport Systems; D001119:Arginase / Q000378:metabolism; D001120:Arginine / Q000378:metabolism*; D001682:Biological Availability; D002956:Citrulline / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000378:metabolism
D026905:Amino Acid Transport Systems; D008565:Membrane Proteins; D002956:Citrulline; D009569:Nitric Oxide; D001120:Arginine; D001119:Arginase