The effect of ascorbic acid and ethanol on the level of thiobarbituric acid reactive substances (TBARS) in selected tissues of albino BALB/c mice.
The aim of the paper was to study the effect of ascorbic acid (vitamin C) and ethanol on the level of thiobarbituric acid reactive substances (TBARS) in the brain, liver, lungs and blood serum of inbred albino BALB/c mice. Sixty male mice divided into 4 groups were used for the study; the mice in each group were injected intraperitoneally (i.p.): Group 1--control, saline; Group 2--H2O2 and FeSO4; Group 3--ascorbic acid (AA); Group 4--AA and ethanol. The level of TBARS in the investigated tissues of the mice in all of the groups was statistically significant higher than in the control group. The highest content of TBARS in blood serum, brain, liver and lung tissue was observed in mice which were given ascorbic acid and ethanol.
Department of Biology of The Ludwik Rydygier Medical University, Bydgoszcz, Poland. alina-wozniak@wp.pl
Alina
A
Woźniak
Bartosz
B
Woźniak
Gerard
G
Drewa
Heliodor Adam
HA
Kasprzak
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D000431:Ethanol / Q000008:administration & dosage*; D005296:Ferrous Compounds / Q000008:administration & dosage; D006861:Hydrogen Peroxide / Q000008:administration & dosage; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*
D005296:Ferrous Compounds; D017392:Thiobarbituric Acid Reactive Substances; C020748:ferrous sulfate; D000431:Ethanol; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid