Statin specific toxicity in organ transplant recipients: case report and review of the literature.
Statins are widely prescribed to organ transplant recipients with hyperlipidemia. We report the case of a cardiac transplant recipient who developed severe rhabdomyolysis and acute renal failure after being switched from pravastatin to simvastatin. The patient's other medications included cyclosporin A and diltiazem. Unlike pravastatin, the metabolism and tissue concentrations of simvastatin--and of other statins - can be greatly affected by these drugs. The propensity of the individual statins to interact with drugs commonly prescribed to transplant recipients is reviewed.
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jina
J
Bae
John A
JA
Jarcho
Mark D
MD
Denton
Colm C
CC
Magee
D058186:Acute Kidney Injury / Q000139:chemically induced*; D016027:Heart Transplantation; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000506:poisoning*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D019821:Simvastatin / Q000506:poisoning*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D017035:Pravastatin