Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12.
Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.
Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA. jxu@wfubmc.edu
Jianfeng
J
Xu
Eugene R
ER
Bleecker
Hajo
H
Jongepier
Timothy D
TD
Howard
Gerard H
GH
Koppelman
Dirkje S
DS
Postma
Deborah A
DA
Meyers
D000293:Adolescent; D000328:Adult; D000375:Aging; D001827:Body Height / Q000235:genetics*; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D020412:Multifactorial Inheritance / Q000235:genetics*; D009426:Netherlands; D012727:Sex Characteristics