Laminin binding conveys mechanosensing in endothelial cells.
In endothelial cells, forces like shear stress are transferred to focal adhesion sites and activate in concert with matrix receptor kinases, leading to an initiation of signaling cascades. The laminin binding protein is one of these matrix receptors and is critically involved in sensing and quantification of shear stress.
Gloe
Torsten
T
Institute of Physiology, Ludwig Maximilians University, 80336 Munich, Germany.
Pohl
Ulrich
U
D000818:Animals; D004730:Endothelium, Vascular / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D017474:Receptors, Laminin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013314:Stress, Mechanical
D007797:Laminin; D017474:Receptors, Laminin