Choanal atresia: the result of maternal thyrotoxicosis or fetal carbimazole?
We present the fourth published case of a child affected with choanal atresia following maternal treatment with carbimazole. The mother was receiving her highest dose of carbimazole at the crucial period for development of the choanae, between days 35 and 38.
Department of Clinical Genetics, Guy's and St. Thomas's Hospital Trust, Guy's Hospital, London, UK. Julian.Barwell@gstt.sthames.nhs.uk
Julian
J
Barwell
Grenville F
GF
Fox
Jonathan
J
Round
Jonathan
J
Berg
D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects*; D002754:Choanal Atresia / Q000139:chemically induced / Q000209:etiology*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D008831:Microcephaly / Q000139:chemically induced / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D013971:Thyrotoxicosis / Q000188:drug therapy*
D013956:Antithyroid Agents; D002231:Carbimazole