Two new HLA-B alleles, B*4422 and B*4704, identified in a study of families with autoimmunity.
HLA-B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA-B*4422 and HLA-B*4704). Sequencing confirmed that both of these new alleles represent novel combinations of previously described sequence motifs, reinforcing the notion that recombination and/or gene conversion-like events play an important role in generating HLA allelic diversity. The identification of these new alleles brings the total number of HLA-B alleles to 465.
Children's Hospital Oakland Research Institute, Oakland, California, USA.
S E
SE
Grams
P V
PV
Moonsamy
C
C
Mano
J R
JR
Oksenberg
A B
AB
Begovich
D000483:Alleles; D000595:Amino Acid Sequence; D015551:Autoimmunity / Q000235:genetics; D001483:Base Sequence; D005192:Family Health; D015235:HLA-B Antigens / Q000235:genetics*; D059948:HLA-B44 Antigen; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic
D015235:HLA-B Antigens; C471441:HLA-B*44:22 antigen; C471442:HLA-B*47:04 antigen; D059948:HLA-B44 Antigen