Emerging bioinformatics for the metabolome.
Metabolic profiling applied to functional genomics (metabolomics) is in an early stage of development. Here, the technologies used for metabolite profiling are briefly covered, illustrated by a few pioneering studies. Issues related to bioinformatics, namely data analysis, visualisation and archival, are the main focus of this review. Arguably there is already a need for databases containing metabolite profiles specific for a single organism, and a generic repository containing all metabolite profiling results, regardless of species. Data analyses and visualisations that combine the biological context with chemistry details are suggested as being the most promising.
Mendes
Pedro
P
Virginia Bioinformatics Institute, and State University, Blacksburg 24061, USA. mendes@vt.edu
D000818:Animals; D019295:Computational Biology / Q000379:methods*; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008660:Metabolism