The use of adenoviral vectors for genetic manipulation and analysis of primitive hematopoietic cells.
Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.
Jordan
C T
CT
Division of Hematology/Oncology, University of Kentucky Medical Center, Lexington, KY 40536, USA. cjordan@pop.uky.edu
Vanin
E F
EF
Marini
F C
FC
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D014161:Transduction, Genetic