RNA interference.
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.
Hannon
Gregory J
GJ
Cold Spring Harbour Laboratory, New York 11724, USA. hannon@cshl.org
D000818:Animals; D020868:Gene Silencing; D005821:Genetic Techniques; D016678:Genome; D008957:Models, Genetic; D012323:RNA Processing, Post-Transcriptional; D012330:RNA, Double-Stranded / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D012330:RNA, Double-Stranded