What is the role of surfactant and inhaled nitric oxide in lung transplantation?
Although numerous studies over the past 40 years have addressed this problem, initial graft failure is still a key question in clinical lung transplantation. As a possible tool to avoid and treat initial graft failure after lung transplantation, laboratory evidence and clinical reports currently emphasize the role of substitution therapy of surfactant combined with inhaled nitric oxide.
Strüber
Martin
M
Hannover Thoracic Transplant Program, Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany. strueber@thg.mh-hannover.de
D000280:Administration, Inhalation; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D009569:Nitric Oxide / Q000627:therapeutic use*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology; D014665:Vasodilator Agents / Q000627:therapeutic use*
D011663:Pulmonary Surfactants; D014665:Vasodilator Agents; D009569:Nitric Oxide