Non-canonical Wnt signalling and regulation of gastrulation movements.
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. m.tada@ucl.ac.uk
Masazumi
M
Tada
Miguel L
ML
Concha
Carl Philipp
CP
Heisenberg
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005775:Gastrula / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism; D008024:Ligands; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins; D014981:Xenopus / Q000196:embryology*; D029867:Xenopus Proteins; D015027:Zebrafish / Q000196:embryology*; D029961:Zebrafish Proteins
D006023:Glycoproteins; D008024:Ligands; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; C092568:Wnt11 protein, zebrafish; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; C512785:wnt11b protein, Xenopus; C094522:wnt8b protein, zebrafish; D002118:Calcium