[Neurotropic activity of lambertian acid and its amino derivatives].
The neurotropic activity of the originally synthesized methyl lambertianate (II), as well as lambertianic acid (I) and three amino derivatives (III-V) was studied. All compounds exhibit equally low toxicity, but differ in the type of influence upon CNS. The most pronounced action was observed for esters II and V. Compound II exhibited a strong antidepressant effect with stimulating action. Introduction of the amino group led to an opposite tendency: compound V exhibited an antipsychotic and sedative (calming) effect upon CNS, without any anticonvulsant action.
Department of Natural and Biologically Active Compounds, Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akad. Lavrent'eva 9, Novosibirsk, 630090 Russia.
T G
TG
Tolstikova
T V
TV
Voevoda
M P
MP
Dolgikh
I V
IV
Sorokina
D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009281:Naphthalenes / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute
D000588:Amines; D000927:Anticonvulsants; D000928:Antidepressive Agents; D002264:Carboxylic Acids; D009281:Naphthalenes; D018696:Neuroprotective Agents; C421442:lambertianic acid