Temperature-rate profiles by polarimetric variable-temperature kinetic experiments to study racemization reactions.
The racemization of (-)-adrenaline was followed by polarimetric variable-temperature kinetic experiments obtaining activation parameters and k(obs)(T) profile in one tenth of the time usually spent for traditional kinetic runs. A polarimeter connected to a computer for the acquisition and processing of the analytical data was used. The kinetic profiles were processed by both an integral method and a differential method. The results are in good agreement with each other and with those obtained by constant-temperature kinetics.
Alibrandi
Giuseppe
G
Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Salita Sperone 31, Villaggio S. Agata, Messina, Italy. alibrandi@chem.unime.it
Coppolino
Salvatore
S
D'Aliberti
Santi
S
Ficarra
Paola
P
Micali
Norberto
N
Villari
Antonino
A
D004355:Drug Stability; D001330:Electronic Data Processing; D004837:Epinephrine / Q000737:chemistry; D007700:Kinetics; D013237:Stereoisomerism; D013696:Temperature
D004837:Epinephrine