Application of the moving-actuator type pump as a ventricular assist device: in vitro and in vivo studies.
A moving actuator type pump has been developed as a multifunctional Korean artificial heart (AnyHeart). The pump consists of a moving actuator as an energy converter, right and left sacs, polymer (or mechanical) valves, and a rigid polyurethane housing. The actuator containing a brushless DC motor moves back and forth on an epicyclical gear train to produce a pendular motion, which compresses both sacs alternately. Of its versatile functions of ventricular assist device and total artificial heart use, we have evaluated the system performance as a single or biventricular assist device through in vitro and in vivo experiments. Pump performance and anatomical feasibility were tested using various animals of different sizes. In the case of single ventricular assist device (VAD) use, one of the sacs remained empty and a mini-compliance chamber was attached to either an outflow or inflow port of the unused sac. The in vitro and in vivo studies show acceptable performance and pump behavior. Further extensive study is required to proceed to human application.
Lee
H S
HS
Biomedical Engineering Department, College of Engineering, Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Korea.
Rho
Y R
YR
Park
C Y
CY
Hwang
C M
CM
Kim
W G
WG
Sun
K
K
Choi
M J
MJ
Lee
K K
KK
Cheong
J T
JT
Shim
E B
EB
Min
B G
BG
D000818:Animals; D002417:Cattle; D003326:Coronary Circulation / Q000502:physiology; D004195:Disease Models, Animal; D004867:Equipment Design; D005240:Feasibility Studies; D006041:Goats; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006353:Heart-Assist Devices; D006736:Horses; D006801:Humans; D066298:In Vitro Techniques; D011859:Radiography; D015203:Reproducibility of Results; D012756:Sheep