Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group.
Synthesis of short peptides using propargyloxycarbonyl amino acid chlorides as effective coupling reagents and polymer supported tetrathiomolybdate as an efficient deblocking agent are reported.
Department of Organic Chemistry, Indian Institute of Science, Bangalore-560 012, India.
Ramakrishna G
RG
Bhat
Surajit
S
Sinha
Srinivasan
S
Chandrasekaran
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000480:Alkynes / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D008982:Molybdenum / Q000737:chemistry* / Q000378:metabolism; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry
D000480:Alkynes; D000596:Amino Acids; D002712:Chlorides; D004791:Enzyme Inhibitors; D010446:Peptide Fragments; D020005:Propanols; D008982:Molybdenum; C020809:tetrathiomolybdate; C028255:propargyl alcohol; D000251:Adenosine Triphosphatases