Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults.
OBJECTIVE
This study tested whether continuous ambulatory peritoneal dialysis (CAPD) changes free or phospholipid-bound choline concentrations in serum or peritoneal dialysis fluid of patients with end stage renal disease (ESRD).


METHODS
Serum and dialysate choline and phospholipid-bound choline were measured before, during and after 6 h CAPD.


RESULTS
Serum choline concentrations were higher in patients with ESRD compared with age-matched controls. CAPD lowered serum choline concentrations significantly although it did not influence phospholipid-bound choline. Choline accumulated in the dialysate, reaching 28.4 +/- 2.7 microM in children and 18.2 +/- 1.4 microM in adults, during six hours CAPD; phospholipid-bound choline increased to 22.9 +/- 2.5 microM and 10.8 +/- 1.4 microM in children and adults, respectively. The total daily loss of choline into the dialysate was 181 +/- 20 micromoles in children and 260 +/- 18 micromoles in adults.


CONCLUSIONS
CAPD causes a substantial loss of choline into peritoneal dialysates and reduces serum choline concentrations significantly.
Ilcol
Yesim Ozarda
YO
Department of Biochemistry, Uludag University Medical School, Bursa, Turkey. ihulus@uludag.edu.tr
Dönmez
Osman
O
Yavuz
Mahmut
M
Dilek
Kamil
K
Yurtkuran
Mustafa
M
Ulus
Ismail H
IH
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002794:Choline / Q000097:blood / Q000378:metabolism*; D002796:Choline Deficiency / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D003124:Colorimetry / Q000379:methods; D015314:Dialysis Solutions / Q000032:analysis*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010743:Phospholipids / Q000097:blood / Q000378:metabolism*
D015314:Dialysis Solutions; D010743:Phospholipids; D002794:Choline