Expression of SNAP-25 during mammalian retinal development: thinking outside the synapse.
The SNARE complex is the core machinery required for vesicle fusion events. Numerous structural, functional, and genetic studies have led to a better understanding of mechanisms that regulate vesicle fusion events during neural development. Studies using the mammalian retina as a model system have increased our understanding of the dynamic patterns of expression of SNARE proteins. In particular, the SNARE complex protein SNAP-25 is expressed in a dynamic fashion during the development of cholinergic amacrine cells in a number of mammalian species. SNAP-25 is also likely to play a crucial role during the development of vertebrate photoreceptors. The integration of comparative studies examining SNARE proteins, such as SNAP-25, provides a powerful approach for the study of CNS development.
Department of Biomedical Sciences and Neuroscience Program, Iowa State University, Ames, IA 50011, USA.
M Heather West
MH
Greenlee
Michael C
MC
Wilson
Donald S
DS
Sakaguchi
D025042:Amacrine Cells / Q000196:embryology; D000818:Animals; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000502:physiology*; D009893:Opossums; D012160:Retina / Q000196:embryology*; D013569:Synapses / Q000502:physiology; D050825:Synaptosomal-Associated Protein 25; D013997:Time Factors
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C494209:Snap25 protein, mouse; D050825:Synaptosomal-Associated Protein 25