Agonodepsides a and B: two new depsides from a filamentous fungus F7524.
Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.
Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park 118240, Singapore. shugeng@merlionpharm.com
Shugeng
S
Cao
Alex S Y
AS
Lee
Yicun
Y
Huang
Horst
H
Flotow
Siewbee
S
Ng
Mark S
MS
Butler
Antony D
AD
Buss
D001426:Bacterial Proteins; D053630:Depsides; D029866:Derris / Q000737:chemistry; D005658:Fungi / Q000737:chemistry*; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology; D009243:NAD / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010088:Oxidoreductases / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010944:Plants / Q000737:chemistry
D001426:Bacterial Proteins; D053630:Depsides; D062385:Hydroxybenzoates; C465813:agonodepside A; C465812:agonodepside B; D009243:NAD; D010088:Oxidoreductases; C085257:InhA protein, Mycobacterium