Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents.
The design and facile synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines is described. These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. ahmedkamal@iict.ap.nic.in
Laxman
N
N
Ramesh
G
G
Srinivas
O
O
Ramulu
P
P
D000588:Amines / Q000737:chemistry; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000494:pharmacology*; D001569:Benzodiazepines / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D011407:Propane / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility; D018675:Toxicity Tests; D014407:Tumor Cells, Cultured
D000588:Amines; D018906:Antineoplastic Agents, Alkylating; D011758:Pyrroles; D001569:Benzodiazepines; D011407:Propane