Alpha-2 macroglobulin I1000 V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease.
Several lines of evidence have revealed some overlapping pathologies in Alzheimer's disease (AD) and Parkinson's disease (PD). Although the alpha-2 macroglobulin gene (A2M) might be a risk factor of these two neurodegenerative diseases, conclusions from different studies have remained conflicting. Here we studied the role of A2M I1000 V polymorphism in both AD and PD in a Chinese Han population. We found that the A2M I/V genotype is associated with both AD (odds ratio (OR)=2.55, 95% confidential interval (95% CI): 1.20-5.43, attributable fraction (AF)=13.65%) and PD (OR=3.03, 95% CI: 1.30-7.02, AF=16.51%). After classifying according to the age of onset, this association is only detected in early-onset AD patients (OR=3.96, 95% CI: 1.28-12.26) and late-onset PD patients (OR=2.61, 95% CI: 0.97-7.09). Therefore, we conclude that in our samples, the A2M I/V genotype might be a susceptibility variant, even with minor effect, for both sporadic AD and PD.
Tang
Guomei
G
State Key Lab of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai 200433, PR China.
Zhang
Mingyuan
M
Xie
Huijun
H
Jiang
Sanduo
S
Wang
Zucheng
Z
Xu
Lin
L
Hao
Yixin
Y
Lin
Dayu
D
Lan
Hekui
H
Wang
Yinyu
Y
Chen
Lishan
L
Ren
Daming
D
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics* / Q000276:immunology; D002681:China / Q000208:ethnology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D000511:alpha-Macroglobulins / Q000235:genetics*
D000511:alpha-Macroglobulins