Dynamic baroreflex control of blood pressure: influence of the heart vs. peripheral resistance.
The aim in the present experiments was to assess the dynamic baroreflex control of blood pressure, to develop an accurate mathematical model that represented this relationship, and to assess the role of dynamic changes in heart rate and stroke volume in giving rise to components of this response. Patterned electrical stimulation [pseudo-random binary sequence (PRBS)] was applied to the aortic depressor nerve (ADN) to produce changes in blood pressure under open-loop conditions in anesthetized rabbits. The stimulus provided constant power over the frequency range 0-0.5 Hz and revealed that the composite systems represented by the central nervous system, sympathetic activity, and vascular resistance responded as a second-order low-pass filter (corner frequency approximately 0.047 Hz) with a time delay (1.01 s). The gain between ADN and mean arterial pressure was reasonably constant before the corner frequency and then decreased with increasing frequency of stimulus. Although the heart rate was altered in response to the PRBS stimuli, we found that removal of the heart's ability to contribute to blood pressure variability by vagotomy and beta(1)-receptor blockade did not significantly alter the frequency response. We conclude that the contribution of the heart to the dynamic regulation of blood pressure is negligible in the rabbit. The consequences of this finding are examined with respect to low-frequency oscillations in blood pressure.
Department of Physiology, University of Auckland, Auckland, New Zealand.
Huang-Ku
HK
Liu
Sarah-Jane
SJ
Guild
John V
JV
Ringwood
Carolyn J
CJ
Barrett
Bridget L
BL
Leonard
Sing-Kiong
SK
Nguang
Michael A
MA
Navakatikyan
Simon C
SC
Malpas
D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D008954:Models, Biological; D011817:Rabbits; D013318:Stroke Volume; D014655:Vascular Resistance / Q000502:physiology*