Immunomodulatory effect of antidepressants.
Basic and clinical studies have provided evidence that the biophase level of monoamines, determined by the balance of their release and uptake, is involved in the pathophysiology and treatment of depression, whereas other arguments cite the role of inflammatory mediators in the etiology of psychiatric disorders. A bidirectional interaction between the monoamine system and the inflammatory system might explain the concurrent therapeutical efficacy and immunomodulatory features of antidepressants.
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, H-1450, Budapest, Hungary. szelenyi@koki.hu
Judith
J
Szelényi
Zsolt
Z
Selmeczy
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015306:Biogenic Monoamines / Q000378:metabolism; D003863:Depression / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D006801:Humans
D000276:Adjuvants, Immunologic; D000928:Antidepressive Agents; D015306:Biogenic Monoamines