Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.
We measured activity and content of cathepsin B in tumor tissues, liver, and spleen in mice with Lewis adenocarcinoma and LS-lymphosarcoma. Cathepsin B activity in Lewis adenocarcinoma cells was lower than in LS-lymphosarcoma cells, which was probably related to differences in their metastatic properties. Antitumor therapy increased activity and content of cathepsin B in tumor tissues. Changes in the content and activity of cathepsin B in tumor tissues can serve as a prognostic criterion for tumor regression during therapy. Cathepsin B is probably involved in apoptosis of tumor cells during chemotherapy of lymphosarcoma-LS with cyclophosphamide.
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. T.A.Korolenko@iph.ma.ru
T A
TA
Korolenko
S Ya
SY
Zhyanaeva
O N
ON
Poteryaeva
O V
OV
Falameeva
O A
OA
Levina
V I
VI
Kaledin
I
I
Shandula
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018827:Carcinoma, Lewis Lung / Q000201:enzymology* / Q000473:pathology; D002401:Cathepsin B / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011379:Prognosis; D013154:Spleen / Q000201:enzymology
D014408:Biomarkers, Tumor; D002401:Cathepsin B