[Pathogenicities of Mycobacterium intracellulare and M. avium strains to the mice which were isolated from non-tuberculous mycobactriosis patients].
The virulence of 5 strains of M. intracellulare and 6 strains of M. avium to mice were examined. The former bacteria were obtained from the patients with mycobacterial pulmonary disease and the latter were from AIDS patients respectively. C57BL/6 (NRAMP-1 susceptible) and its NRAMP-1 congenic mice (resistant) were used to evaluate the virulence of these bacteria. Three of the 5 strains of M. intracelllulare showed a relatively high virulence. They grew in the liver, spleen and lungs of susceptible mice and even in the lungs of resistant mice. On the other hand, none of 6 strains of M. avium could grow in either susceptible or resistant mice. In conclusion, our mouse model may be a useful tool for evaluating the virulence of bacteria isolated from mycobacteriosis patients.
Department of Veterinary Microbiology, Faculty of Agriculture, Miyazaki University.
Yoshitaka
Y
Goto
Akira
A
Iwakiri
Toshiharu
T
Shinjo
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000818:Animals; D006801:Humans; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D009162:Mycobacterium avium / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*; D015269:Mycobacterium avium Complex / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*; D015270:Mycobacterium avium-intracellulare Infection / Q000382:microbiology; D013154:Spleen / Q000382:microbiology; D014774:Virulence