New Pd-catalyzed selective reduction of carboxylic acids to aldehydes.
A catalyst generated in situ from palladium acetate and tricyclohexylphosphine efficiently catalyzes the reduction of carboxylic acids with sodium hypophosphite in the presence of pivalic anhydride to give aldehydes with high selectivity. The low cost and convenient handling of the reagents makes this process a valuable alternative to hydrogenations and metal hydride reductions.
Goossen
Lukas J
LJ
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany. goossen@mpi-muelheim.mpg.de
Ghosh
Keya
K
D000447:Aldehydes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000494:pharmacology*; D010721:Phosphinic Acids / Q000737:chemistry
D000447:Aldehydes; D002264:Carboxylic Acids; D010721:Phosphinic Acids; D010165:Palladium; C009287:sodium hypophosphite