[Multiple latency test in a patient with episodes of sleep induced by pergolide].
OBJECTIVE
Recently, there have been report sleep attacks in parkinsonian patients as a side effect of pramipexole and ropinirole. We report a patient with similar episodes related with pergolide.


METHODS
A 64 year old man with rigid akinetic parkinsonism, treated with carbidopa/levodopa and pergolide, developed sudden, irresistible sleep episodes after increasing the dose of pergolide to 2.25 mg/day because of bad control of parkinsonian symptoms. These episodes started 30 minutes after each dose of pergolide and lasted 2 hours. Following reduction of the dose of pergolide to 1.5 mg/day the sleep episodes disappeared. Two double blind multiple sleep latency tests were performed, one after intaking pergolide and other after intaking placebo.


RESULTS
The latencies to sleep onset were lower with pergolide than with placebo, but the differences did not reach statistical significance. There was no premature REM sleep onset.


CONCLUSIONS
Sleep episodes are likely a not specific effect of dopamine agonists
Servico de Neurología, Hospital Principe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España. fjimenezj@meditex.es
F J
FJ
Jiménez-Jiménez
I
I
Velasco
M
M
de Toledo
Y
Y
Sayed
J
J
Zurdo
M
M
Ortí-Pareja
D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D018849:Controlled Clinical Trials as Topic; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D010479:Pergolide / Q000009:adverse effects* / Q000627:therapeutic use; D012893:Sleep Wake Disorders / Q000139:chemically induced*
D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D010479:Pergolide