[Hepatoprotective properties of liproxol].
The experiments on rats with a model toxic liver damage (tetrachloromethane hepatitis) showed evidence of a high hepatoprotector activity of liproxol, representing a combination of eplir and lokhein mixed in a 1-12 ratio. Liproxol inhibits lipid peroxidation, stimulates the excretory and detoxicant functions of liver, reduces hyperfermentation, and normalized membrane phospholipid composition.
Saratikov
A S
AS
Pharmacology Department, Siberian Medical University, Moskovskii trakt 2, Tomsk, 634050 Russia.
Litvinenko
Iu A
IuA
Burkova
V N
VN
Vengerovskiĭ
A I
AI
Chuchalin
V S
VS
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D002338:Carotenoids / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D004338:Drug Combinations; D008658:Inactivation, Metabolic; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010743:Phospholipids / Q000032:analysis / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats
D000975:Antioxidants; D004338:Drug Combinations; D010743:Phospholipids; D010936:Plant Extracts; C064845:eplir; C108292:lochein; D002338:Carotenoids