Cerebral cystine uptake: a tale of two transporters.
Transport of cystine across the cell membrane is essential for synthesis of the major cellular antioxidant glutathione. Cystine uptake in the brain occurs by both the Na(+)-independent x(c)(-) cystine-glutamate exchanger and the X(AG)(-) family of high-affinity, Na(+)-dependent glutamate transporters. New evidence concerning the role of cystine transport in the defence against oxidative stress is described.
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. Gethin.McBean@ucd.ie
Gethin J
GJ
McBean
D027322:Amino Acid Transport System X-AG / Q000378:metabolism* / Q000502:physiology; D027182:Amino Acid Transport System y+; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology; D003553:Cystine / Q000378:metabolism*; D006801:Humans
D027322:Amino Acid Transport System X-AG; D027182:Amino Acid Transport System y+; D002352:Carrier Proteins; C118895:SLC7A11 protein, human; D003553:Cystine