[A European discussion about stem cells for therapeutic use].
Stem cells as a source material for growing cellular transplants to repair dysfunctional organs appear to be a new challenge for medical science. Though stem cells are also present in foetal and adult organs, embryonic stem cells from the pre-implantation embryo in particular have the potency to proliferate easily in vitro and the capacity to differentiate into all the body's organ-specific cells. Therefore, these are the ideal cells for developing new cell transplantation therapies for diseases such as Parkinson's disease, diabetes mellitus and heart failure. The use of spare in vitro fertilization (IVF) embryos or pre-implantation embryos specially created to harvest human embryonic stem cells is, however, controversial and an ethical problem. In a European discussion platform organised by the European Commission Research Directorate-General, the status quo of the progress was presented and subsequently commented upon and discussed in terms of medical-ethical, social, industrial and patient interests. The expectations of this new medical technology were high, but clinical trials seem only acceptable once the in vitro differentiation of stem cells can be adequately controlled and once it is known how in vitro prepared stem cells behave after implantation. The ethical justification of the use of in vitro pre-implantation embryos remains controversial. The prevailing view is that the interests of severely ill patients for whom no adequate therapy exists, surmounts the interest of protection of a human in vitro pre-implantation embryo, regardless of whether it was the result of IVF or of transplantation of a somatic cell nucleus of the patient in an enucleated donor egg cell (therapeutic cloning).
Boer
G J
GJ
Nederlands Instituut voor Hersenonderzoek, werkgroep Neuroregeneratie, Meibergdreef 33, 1105 AZ Amsterdam. g.boer@nih.knaw.nl
D002454:Cell Differentiation; D002469:Cell Separation; D002999:Clone Cells; D019976:Cloning, Organism / Q000379:methods; D004622:Embryo, Mammalian / Q000166:cytology*; D004992:Ethics, Medical; D016332:Fetal Tissue Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D020858:Tissue and Organ Harvesting