Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease.
The inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis) are a collection of chronic idiopathic inflammatory disorders of the intestine and/or colon. Although the pathophysiology of IBD is not known with certainty, a growing body of experimental and clinical data suggests that chronic gut inflammation may result from a dysregulated immune response to normal bacterial antigens. This uncontrolled immune system activation results in the sustained overproduction of reactive metabolites of oxygen and nitrogen. It is thought that some of the intestinal and/or colonic injury and dysfunction observed in IBD is due to elaboration of these reactive species. This review summarizes the current state-of-knowledge of the role of reactive oxygen species and nitric oxide in the pathophysiology of IBD.
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
Kevin P
KP
Pavlick
F Stephen
FS
Laroux
John
J
Fuseler
Robert E
RE
Wolf
Laura
L
Gray
Jason
J
Hoffman
Matthew B
MB
Grisham
D000818:Animals; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology*; D008954:Models, Biological; D009569:Nitric Oxide / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species; D009569:Nitric Oxide