[Study on polymorphism of human leukocyte antigen-DRB1 allele in patients with endometriosis].
OBJECTIVE
To study the possibility of a correlation between occurrence of endometriosis (EM) and polymorphism of human leukocyte antigen (HLA) DRB1 allele.


METHODS
Polymorphism of HLA-DRB1 allele were detected by polymerase chain reaction- sequence specific primers (PCR-SSP) testing 40 surgically proven EM patients and 50 normal control.


RESULTS
At HLA-DRB1 15 allele, positive frequency of EM group was significant higher as compared with those of the normal control group [45.0% vs 26.0%, P < 0.05, relative risk (RR) = 2.1]. Other HLA-DRB1 allele positive frequency of EM group and control group had no significant difference. But for Polymorphism of DRB1 * 15 allele, positive frequency of EM group and control group had no significant difference [1501 : 35.0% vs 20.0%; 1502 : 10.0% vs 6.0%; P > 0.05].


CONCLUSIONS
The occurrence of EM may be associated with the presence of HLA-DRB1 allele, but hasn't associated about polymorphism of DRB1* 15 allele. HLA-DRB1 * 15 maybe one of some factors for the pathogenesis of endometriosis.
Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Xin
X
Wang
Chunyu
C
Liu
Qiuhua
Q
Lin
Xiaoling
X
Fang
Li
L
Lin
Qiyuan
Q
Mei
D000328:Adult; D000483:Alleles; D004715:Endometriosis / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains