Histone methylation: dynamic or static?
Methylation of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark on histones, or can it be removed by an active process necessary for regulated gene expression?
Wellcome Trust/Cancer Research UK Institute, Department of Pathology, University of Cambridge, Tennis Court Road, cambridge CB2 1QR, United Kingdom.
Andrew J
AJ
Bannister
Robert
R
Schneider
Tony
T
Kouzarides
D000595:Amino Acid Sequence; D000818:Animals; D001120:Arginine / Q000378:metabolism; D005786:Gene Expression Regulation; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D008969:Molecular Sequence Data
D006657:Histones; D001120:Arginine; D008239:Lysine