Multifocal motor neuropathy and Campylobacter jejuni reactivity.
In some patients, Campylobacter jejuni infection has been associated with the development of multifocal motor neuropathy (MMN) and high titers of antiganglioside antibodies. The authors measured anti-C. jejuni antibodies by ELISA and immunoblot in 20 patients with MMN, and correlated their presence with antiganglioside reactivity and a history of recent diarrhea. Only one patient had high titers of anti-C. jejuni antibodies, indicating that C. jejuni is unlikely to be involved in the pathogenesis of MMN in most patients.
Giorgio Spagnol Service of Clinical Neuroimmunology, Department of Neurological Sciences, Dino Ferrari Center, Milan University, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Fabrizia
F
Terenghi
Silvia
S
Allaria
Guglielmo
G
Scarlato
Eduardo
E
Nobile-Orazio
D000907:Antibodies, Bacterial / Q000097:blood*; D002169:Campylobacter Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D016123:Campylobacter jejuni / Q000276:immunology*; D003967:Diarrhea / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011115:Polyneuropathies / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology
D000907:Antibodies, Bacterial; D005732:Gangliosides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M