A model recognition switch. Electrochemical control and transduction of imidazole binding by electrode-immobilized microperoxidase-11.
Electrode-immobilized microperoxidase-11 exhibited a titratable potentiometric response to imidazole, demonstrating both molecular recognition and the capability for "switchable" changes in the affinity of an immobilized redox-receptor for a target ligand.
Goldston
Harold M
HM
Center for Bio/molecular Science & Engineering, Naval Research Laboratory, Washington, DC 20375, USA.
Scribner
Alicia N
AN
Trammell
Scott A
SA
Tender
Leonard M
LM
D004563:Electrochemistry; D004566:Electrodes; D004800:Enzymes, Immobilized / Q000378:metabolism*; D007093:Imidazoles / Q000493:pharmacokinetics*; D010544:Peroxidases / Q000378:metabolism*; D011485:Protein Binding; D017186:Titrimetry
D004800:Enzymes, Immobilized; D007093:Imidazoles; D010544:Peroxidases; C021799:microperoxidase