Sleep disordered breathing--a new component of syndrome x?
Sleep disordered breathing (SDB) is a complication of obesity estimated to occur in about 4-6% of overweight individuals. These respiratory disturbances during sleep incorporate a number of conditions including snoring, upper airway resistance syndrome and obstructive sleep apnoea syndrome (OSAS). It is thought that as well as having deleterious effects on sleep quality these conditions may also promote cardiovascular and hormonal changes leading to an elevated blood pressure and an increased incidence of cardiovascular morbidity. Evidence reviewed here points to an alteration in sympathovagal balance, baroreceptor sensitivity, insulin resistance and leptin, growth hormone and lipid levels. Whether these changes are a consequence of the associated obesity or the SDB itself remains to be proven.
Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK.
S
S
Coughlin
P
P
Calverley
J
J
Wilding
D002318:Cardiovascular Diseases / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology; D024821:Metabolic Syndrome; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000209:etiology*; D012893:Sleep Wake Disorders / Q000209:etiology; D012913:Snoring / Q000209:etiology