A clinical and experimental study on the protective effects of jiangzhi tongmai fang on endothelial injury.
31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang ([symbol: see text], formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was antiatherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1 alpha and decreasing the release of endothelin (ET) as evidenced in the experimental study.
Dongzhimen Hospital, Beijing TCM University, Beijing 100700.
Yahong
Y
Wang
Fuling
F
Niu
Mingjing
M
Zhao
Bei
B
Zhong
Jinghong
J
Hao
Weihong
W
Yan
Xiying
X
Lu
Wei
W
Wang
Qiang
Q
Li
Qian
Q
Lin
Yanyan
Y
Dai
Yong
Y
Zhao
Min
M
Xiao
Ling
L
Tang
Lanying
L
He
Xueying
X
Jiang
Weiqin
W
Guo
Shuoren
S
Wang
Weixing
W
Lu
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy*; D008078:Cholesterol, LDL / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D008148:Lovastatin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011817:Rabbits
D008078:Cholesterol, LDL; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D015121:6-Ketoprostaglandin F1 alpha; D008148:Lovastatin