Supramolecular structures of metronidazole and its copper(II), cobalt(II) and zinc(II) coordination compounds.
In this work we present the synthesis and structural and spectroscopic characterization of Cu(II), Co(II) and Zn(II) coordination compounds with the antibiotic metronidazole ([double bond]emni). Coordination to metal ions is through its imidazolic nitrogen, while the hydroxyethyl and nitro groups act as supramolecular synthons. [Co(emni)(2)Br(2)], and [Zn(emni)(2)X(2)] (X(-)=Cl, Br) stabilize zig-zag chains, and a 2D supramolecular structure is formed by inter-chain contacts through inter-molecular hydrogen-bonding. Pleated sheet or layers are formed by [Co(emni)(2)Cl(2)] and [Cu(emni)(2)Cl(H(2)O)](2)Cl(2), respectively. The dinuclear Cu(II) compound [Cu(emni)mu(O(2)CMe)(2)](2) gives a one-dimensional zig-zag arrangement. The contribution of metal ions in metronidazole coordination compounds is shown in the stabilization of the different aggregate structures.
Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, Cuidad Universitaria, México D.F. 04510, Mexico.
Nadeshda
N
Galván-Tejada
Sylvain
S
Bernès
Silvia E
SE
Castillo-Blum
Heinrich
H
Nöth
Ramon
R
Vicente
Noráh
N
Barba-Behrens
D000890:Anti-Infective Agents / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D008280:Magnetics; D008795:Metronidazole / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*
D000890:Anti-Infective Agents; D008795:Metronidazole; D003035:Cobalt; D003300:Copper; D015032:Zinc