Six new HLA class I alleles detected by PCR-SSO genotyping.
This paper describes six new alleles; A*0240, A*2614, B*3924, B*4425, Cw*0807 and Cw*12023, which were discovered during routine genotyping with sequence specific oligonucleotides (SSO's). Five of the new alleles have changes in residues which belong to the antigen binding site of the HLA protein. These new variants may have altered antigen binding properties and may cause differential immunological responses that could affect transplantation outcome1.
Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia.
C T
CT
Kennedy
W D
WD
Greville
R
R
Dodd
T
T
Le
A
A
Taverniti
G
G
Chapman
R
R
Wallace
A
A
Kennedy
J
J
Strickland
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Dunckley
D001483:Base Sequence; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens / Q000235:genetics*; D059946:HLA-B39 Antigen; D059948:HLA-B44 Antigen; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction
D015234:HLA-A Antigens; C471433:HLA-A*02:40 antigen; C471434:HLA-A*26:14 antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; C471435:HLA-B*39:24 antigen; C471436:HLA-B*44:25 antigen; D059946:HLA-B39 Antigen; D059948:HLA-B44 Antigen; D015236:HLA-C Antigens; C471437:HLA-C*08:07 antigen; C471438:HLA-C*12:02:03 antigen