Changes in the ratio between apolipoprotein (a) and lipids in human plasma during interaction with polyclonal sheep antibodies against lipoprotein (a).
Plasma contents of apolipoprotein (a), apolipoprotein B 100, cholesterol, triglycerides, and vitamin E were measured in 2 patients with lipoprotein (a) concentration >100 mg/dl during the interaction with the anti-lipoprotein (a) immunosorbent. Intraindividual heterogeneity of apolipoprotein (a)-containing particles in the plasma was demonstrated. Polyclonal antibodies against lipoprotein (a) immobilized on Sepharose CL-4B more effectively removed free apolipoprotein (a) than complexes containing apolipoproteins B 100, apolipoprotein (a), lipids, and vitamin E.
Chernyad'eva
I F
IF
Laboratory of Hemodialysis and Plasmapheresis, A. L. Myasnikov Institute of Cardiology, Russian Research-and-Production Center for Cardiology, Russian Ministry of Health, Moscow.
Lopata
N S
NS
Afanasieva
O I
OI
Pokrovskii
S N
SN
Kukharchuk
V V
VV
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001053:Apolipoproteins / Q000097:blood* / Q000276:immunology; D053241:Apoprotein(a); D002784:Cholesterol / Q000097:blood*; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood* / Q000276:immunology; D012756:Sheep / Q000276:immunology; D014280:Triglycerides / Q000097:blood*
D000906:Antibodies; D001053:Apolipoproteins; D017270:Lipoprotein(a); D014280:Triglycerides; D002784:Cholesterol; D053241:Apoprotein(a)