Total synthesis of fostriecin (CI-920) via a convergent route.
Fostriecin, a potent and promising antitumor antibiotic, was stereoselectively synthesized via a convergent route involving a three-segement coupling procedure.
Miyashita
Kazuyuki
K
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Ikejiri
Masahiro
M
Kawasaki
Hitomi
H
Maemura
Satoko
S
Imanishi
Takeshi
T
D000475:Alkenes / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D004952:Esters / Q000737:chemistry; D008293:Malates / Q000737:chemistry; D011090:Polyenes; D011753:Pyrones; D013237:Stereoisomerism
D000475:Alkenes; D000903:Antibiotics, Antineoplastic; D004791:Enzyme Inhibitors; D004952:Esters; D008293:Malates; D011090:Polyenes; D011753:Pyrones; C030298:malic acid; C040313:fostriecin