[Genetics and genomics of long QT syndrome].
In the past decade, molecular genetics has revealed that some life-threatening arrhythmogenic disorders, such as long QT syndrome, are due to mutated genes encoding ion channels that generate the cardiac action potential. Great efforts made in various fields have partly solved problems caused by unforeseen genetic diversity of these congenital arrhythmogenic disorders, while the genetics of these disorders has recently proved to be applicable to very wide-ranging conditions associated with sudden cardiac death, and increased knowledge about the human genome will revolutionize researches into arrhythmic diseases in future. The purpose of this review is to outline the recent advances and problems in the molecular genetics in long QT syndrome.
Iwasa
Hiroyasu
H
Second Department of Internal Medicine, Gunma University School of Medicine.
D016757:Death, Sudden, Cardiac / Q000209:etiology; D006580:Genetic Carrier Screening; D006801:Humans; D007473:Ion Channels / Q000235:genetics; D008133:Long QT Syndrome / Q000175:diagnosis / Q000235:genetics*; D009154:Mutation; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide
D007473:Ion Channels