Recent clinical evidence of the efficacy and safety of thiamphenicol glycinate acetylcysteinate and thiamphenicol glycinate.
Thiamphenicol is a broad-spectrum antimicrobial agent active against penicillin-resistant Streptococcus pneumoniae, Staphylococcus aureus VISA strains, most methicillin-resistant isolates and atypical pathogens such as Mycoplasma pneumoniae and Chlamydia pneumoniae). Thiamphenicol is present as glycinate hydrochloride (TG) and glycinate acetylcysteinate (TGA) esters in the parenteral and aerosol dosage form. This multicenter, double-blind, randomized clinical trial aimed to evaluate the efficacy and tolerability of aerosol administration of TGA, compared to TG, in the treatment of acute and/or exacerbated infections of the respiratory tract. Results showed that both treatments ameliorated the symptoms (frequency and severity of cough, difficulty in expectoration) associated with the evaluated pathologies, i.e. tracheobronchitis, acute and exacerbated chronic bronchitis. The investigators rated both treatments Good or Very Good in 90% of patients at the end of treatment, with "Very Good" for patients treated with TGA (37%) compared to 28% of patients treated with TG. Both treatments were well tolerated with fewer than 5% of patients experiencing an adverse event.
Postgraduate School for Respiratory Diseases-University of Pavia, Italy. tisiolmm@ipv36.unipv.it
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Grassi
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De Benedetto
D000111:Acetylcysteine / Q000008:administration & dosage / Q000627:therapeutic use*; D000280:Administration, Inhalation; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001991:Bronchitis / Q000188:drug therapy* / Q000473:pathology; D003371:Cough / Q000188:drug therapy / Q000473:pathology; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C028814:thiamphenicol glycinate acetylcysteinate; D013839:Thiamphenicol; C028813:thiamphenicol glycinate; D000111:Acetylcysteine