Syntheses and advanced NMR structure determination of androsteno-[17,16-d]-pyrimidine derivatives.
Reactions of 16-hydroxymethylene- and 16-aminomethylene-3beta-hydroxy-5-androsten-17-one with formamide and guanidine were carried out resulting in the formation of [16,17-d]-pyrimidine rings. Advanced two-dimensional NMR methods were used to investigate the structure of the products. Homonuclear-, and heteronuclear chemical shift correlation experiments yielded the complete 1H-, 13C- and 15N signal assignment for these compounds.
Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720, Szeged, Hungary. pforgo@chem.u-szeged.hu
Peter
P
Forgo
Irén
I
Vincze
D000736:Androstenes / Q000138:chemical synthesis* / Q000737:chemistry; D000738:Androsterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*
D000736:Androstenes; D011743:Pyrimidines; C472315:androsteno-(17,16-d)-pyrimidine; D000738:Androsterone; C030986:pyrimidine