C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469). A risk factor for coronary heart disease and myocardial infarction.
BACKGROUND
The intercellular adhesion molecule-1 (ICAM-1) mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of coronary atherosclerosis. ICAM-1 single-base C/T polymorphism, which determines an amino acid substitution in the ICAM-1 protein in exon 6 codon 469, has been described. Our purpose was to determine whether this C/T polymorphism influences the risk of coronary heart disease (CHD) and myocardial infarction (MI) in humans.


RESULTS
We enrolled 349 patients with angiographically documented CHD, including a sub-group of 179 patients with acute or chronic MI. The control group consisted of 213 patients with normal left ventricular function and no documented evidence of CHD. All patients and controls were Germans genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for the ICAM-1 polymorphism. In the patients with CHD and MI the frequencies of the T genotype (TT+TC) were significantly higher than the CC genotype compared to the control subjects (P<0.001). With the additional use of multivariable logistic regression analysis for CHD (TT+TC versus CC; P=0.011, odds ratio 2.21, 95% CI 1.20-4.07), we found a significant association between CHD and MI and the TT and TC genotype of the ICAM-1 gene polymorphism.


CONCLUSIONS
These results suggest that the TT and TC genotype of the ICAM-1 gene polymorphism in codon 469 is a genetic factor that may determine an individual's susceptibility for CHD and MI.
Heart Center Wuppertal, University of Witten-Herdecke, Arrenbergerstr. 20, 42117 Wuppertal, Germany. hong.jiang@uni-duesseldorf.de
Hong
H
Jiang
Rolf Michael
RM
Klein
Dieter
D
Niederacher
Ming
M
Du
Roger
R
Marx
Mark
M
Horlitz
Guido
G
Boerrigter
Harald
H
Lapp
Thomas
T
Scheffold
Ingo
I
Krakau
Hartmut
H
Gülker
D000368:Aged; D000483:Alleles; D003062:Codon / Q000235:genetics*; D003327:Coronary Disease / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D003062:Codon; D005819:Genetic Markers; D018799:Intercellular Adhesion Molecule-1