Mice that are congenic for the char2 locus are susceptible to malaria.
A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia.
Rachel A
RA
Burt
Vikki M
VM
Marshall
Jamie
J
Wagglen
Fleur R
FR
Rodda
Danielle
D
Senyschen
Tracey M
TM
Baldwin
Lynn A
LA
Buckingham
Simon J
SJ
Foote
D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D008288:Malaria / Q000235:genetics*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D019655:Quantitative Trait, Heritable