Incidence, epidemiology, and characteristics of quinolone-nonsusceptible Streptococcus pneumoniae in Croatia.
Among 585 Streptococcus pneumoniae strains isolated in 22 Croatian hospitals 21 strains (3.6%) were quinolone nonsusceptible. MICs of all quinolones were high for seven strains tested with the same serotype (23F) and mutations in gyrA, parC, and parE. The remaining 14 strains were more heterogeneous and had mutations only in parC and/or parE, and the MICs of quinolones were lower for these strains.
Pankuch
Glenn A
GA
Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.
Bozdogan
Bülent
B
Nagai
Kensuke
K
Tambić-Andrasević
Arjana
A
Schoenwald
Slavko
S
Tambić
Tera
T
Kalenić
Smilja
S
Plesko
Sanja
S
Tepes
Nastja K
NK
Kotarski
Zdenka
Z
Payerl-Pal
Marina
M
Appelbaum
Peter C
PC
D042462:4-Quinolones; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology; D017523:Croatia / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004352:Drug Resistance, Microbial; D005260:Female; D005843:Geography; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D012737:Sex Factors; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics
D042462:4-Quinolones; D000900:Anti-Bacterial Agents