Relation between adenosine deaminase activities and cytokine-producing T cells in women with preeclampsia.
OBJECTIVE
To investigate the relation between plasma adenosine deaminase (ADA) activity and cytokine-producing T cells in preeclampsia.


METHODS
Plasma ADA activity and the proportions of cytokine-producing T cells were measured in peripheral blood of 28 women with normal pregnancies and preeclampsia. The proportion of CD4-positive T cells producing interferon-gamma and interleukin-4 were analyzed by flow cytometry.


RESULTS
Plasma ADA activity in preeclampsia was significantly higher than that in normal pregnancy (p < 0.05). In preeclampsia, the proportion of interferon-gamma producing cells significantly increased, and the proportion of interleukin-4 producing cells was significantly decreased compared with normal pregnancy. A significant correlation was found between ADA activity and the proportion of interferon-gamma producing cells in preeclampsia (r = 0.58, p < 0.05).


CONCLUSIONS
Increased plasma ADA activity in preeclampsia may be in part associated with changes in the proportion of interferon-gamma secreting cells.
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@ nms.ac.jp
Yoshio
Y
Yoneyama
Rintaro
R
Sawa
Shunji
S
Suzuki
Atsushi
A
Miura
Hajime
H
Kobayashi
Daisuku
D
Doi
Koichi
K
Yoneyama
Tsutomu
T
Araki
D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D003124:Colorimetry / Q000379:methods; D005215:Fasting / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000097:blood* / Q000378:metabolism; D015847:Interleukin-4 / Q000097:blood* / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood* / Q000201:enzymology; D011247:Pregnancy; D013223:Statistics as Topic; D018417:Th1 Cells / Q000166:cytology / Q000378:metabolism*; D018418:Th2 Cells / Q000166:cytology / Q000378:metabolism*
D015847:Interleukin-4; D007371:Interferon-gamma; D000243:Adenosine Deaminase