False positive uptake of metaiodobenzylguanidine in hepatocellular carcinoma.
We present the case of a patient who showed increased accumulation of (123)I-metaiodobenzylguanidine (MIBG) in hepatocellular carcinoma, leading to a false presumptive diagnosis of intrahepatic neuroendocrine tumour. The increase in uptake was not seen on images obtained 4 h after tracer injection but was evident on those taken after 24 h, suggesting slower washout from the liver tumour than from non-tumoural liver parenchyma. Our observations indicate that a non-neuroendocrine malignant tumour may exhibit high accumulation of MIBG associated with prolonged retention.
Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Y
Y
Inoue
M
M
Akahane
T
T
Kitazawa
H
H
Ijichi
S
S
Obi
K
K
Yoshikawa
K
K
Ohtomo
M
M
Omata
D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics*; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000378:metabolism*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine