Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis.
OBJECTIVE
Non-alcoholic steatohepatitis (NASH), the association of steatosis with an inflammatory response, is a novel liver disease of unknown pathogenesis and prognosis. Triacylglycerols and their precursors, the fatty acids, are the likely candidates to accumulate in the hepatocyte. Disturbed fatty acid metabolism can be involved in the pathogenesis of NASH but there is no information concerning its plasma fatty acid profile. The aim of this study was to evaluate plasma total (esterified plus free) and free fatty acids concentrations to assess the association of NASH with plasma fatty acid accumulation.


METHODS
Overnight fasting blood samples from 22 biopsy-proven NASH patients and of 6 matched age healthy controls were studied.


RESULTS
NASH patients had significantly higher concentration of total and free fatty acids than controls (P<0.05), higher total saturated and monounsaturated levels in both studied lipid fractions (P<0.05), mainly due to the increase of hexadecanoic, hexadecenoic and octadecenoic acids. Absolute polyunsaturated fatty acids (PUFA) concentrations were similar in both groups. The C20:4/C18:2 and the C18:1/C18:0 ratios as well as the peroxidability index were not significantly different.


CONCLUSIONS
In overweight/obese patients NASH is associated with deranged fatty acid metabolism which may be involved in its pathogenesis and/or progression.
Centro de Patogénese Molecular, FFUL, Lisboa, Portugal.
I Tavares
IT
de Almeida
H
H
Cortez-Pinto
G
G
Fidalgo
D
D
Rodrigues
M E
ME
Camilo
D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D018450:Disease Progression; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005234:Fatty Liver / Q000097:blood / Q000209:etiology*; D005260:Female; D006505:Hepatitis; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged
D005230:Fatty Acids, Nonesterified