Two novel vaginal microbicides (polystyrene sulfonate and cellulose sulfate) inhibit Gardnerella vaginalis and anaerobes commonly associated with bacterial vaginosis.
This is the first report demonstrating the in vitro inhibitory activity of two novel microbicides (cellulose sulfate and polystyrene sulfonate) against bacterial vaginosis (BV)-associated bacteria. Vaginal application of these microbicides not only may reduce the risk of acquisition of human immunodeficiency virus and other sexually transmitted infection-causing organisms but may also decrease the incidence of BV.
Simoes
Jose A
JA
Department of Obstetrics and Gynecology, Rush University, Rush-Presbyterian-St Luke's Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA.
Citron
Diane M
DM
Aroutcheva
Alla
A
Anderson
Robert A
RA
Chany
Calvin J
CJ
Waller
Donald P
DP
Faro
Sebastian
S
Zaneveld
Lourens J D
LJ
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000254:growth & development; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004058:Diffusion; D005260:Female; D006194:Gardnerella vaginalis / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests; D011137:Polystyrenes / Q000494:pharmacology*; D016585:Vaginosis, Bacterial / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011137:Polystyrenes; C003321:polystyrene sulfonic acid; D002482:Cellulose; C020254:cellulose sulfate