Preliminary Study on Gene Therapy of PD Monkey Using Microcapsulated Rat Transgenetic Myoblasts.
Rat myoblast cells transfected with tyrosine hydroxylase gene were microcapsulated using the ALG/PLL system. These microcapsulated cells could survive grow and produce tyrosine hydroxylase(TH)for at least two months in vitro. After the implantation of these microcapsules into monkey striatum microcapsulated cells still survived one month more. No obvious gliosis was seen around implanted microcapsules. Then the microcapsules were transplanted into the striatum of PD monkeys and their typical PD rotation numbers were significantly decreased.
Shanghai Institute of Biochemistry the Chinese Academy of Sciences Shanghai 200031 China. sib203@sunm.shcnc.ac.cn
Qiong
Q
Jiang
Shi-Yun
SY
Li
Zheng-Guo
ZG
Liu
Jian
J
Liu
Sheng-Di
SD
Chen
Zhong-Cheng
ZC
Zheng
Xin-Yuan
XY
Liu