Gene therapy for prostate cancer.
Prostate cancer is the most common noncutaneous cancer in man. When confined to the prostate it can be cured by radical prostatectomy or irradiation therapy. However, there are no curative therapies for locally advanced, recurrent or metastatic disease. Prostate cancer gene therapy has recently transition from preclinical studies to clinical trials with the goal of developing novel treatments for prostate cancer. The greatest challenge in treating advanced prostate cancer is therapeutic access to and the elimination of metastases. This review details two aspects of prostate cancer gene therapy, the types of delivery systems under development and specific categories of therapeutic genes available with an emphasis on the mechanism of action of specific gene therapy strategies.
Scott Department of Urology, Baylor College of Medicine, 6560 Fannin, Suite 2100, Houston, TX 77030, USA.
Yehoshua
Y
Gdor
Terry L
TL
Timme
Brian J
BJ
Miles
Dov
D
Kadmon
Timothy C
TC
Thompson
D000276:Adjuvants, Immunologic / Q000235:genetics / Q000627:therapeutic use*; D017209:Apoptosis / Q000235:genetics; D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000627:therapeutic use; D043525:Cytosine Deaminase; D004167:Diphtheria Toxin / Q000235:genetics / Q000627:therapeutic use; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009700:Nucleoside Deaminases / Q000235:genetics / Q000627:therapeutic use; D011355:Prodrugs / Q000378:metabolism / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000235:genetics / Q000628:therapy*; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D015815:Cell Adhesion Molecules; D004167:Diphtheria Toxin; D011355:Prodrugs; D013937:Thymidine Kinase; D009700:Nucleoside Deaminases; D043525:Cytosine Deaminase