Myc-Is this the oncogene from Hell?
A new paper implicates the Myc oncoprotein in the direct induction of DNA damage and consequent genome instability in cultured cells. However, it is less clear whether Myc induces the same genetic pandemonium in vivo.
Soucek
Laura
L
Cancer Research Institute, University of California, San Francisco, Cancer Center, 2340 Sutter Street, 94143, USA.
Evan
Gerard
G
D004249:DNA Damage / Q000502:physiology*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
D016271:Proto-Oncogene Proteins c-myc; D017382:Reactive Oxygen Species