Expression of the chick vascular endothelial growth factor D gene during limb development.
Vascular endothelial growth factor D (VEGF-D) is a member of the VEGF/PDGF superfamily that has been implicated in angiogenesis and lymphangiogenesis. We have isolated a chick cDNA that shows homology with VEGF-D (also known as FIGF, c-fos-induced growth factor) of other species. Here, we describe the expression pattern of cVegf-D in chick embryos. In the limb buds, cVegf-D shows a dynamic expression pattern that is restricted to the mesenchyme of the posterior region. cVegf-D expression is also detected in the ectoderm and mesenchyme of the head region, somites, notochord and pharyngeal arches. We also report on the capability of Sonic hedgehog and retinoic acid to regulate cVegf-D expression.
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Aptdo. 14, 2780-156 Oeiras, Portugal. ramont@igc.gulbenkian.pt
Ramón Díaz
RD
Trelles
Joaquín Rodríguez
JR
León
Yasuhiko
Y
Kawakami
Sofia
S
Simoes
Juan Carlos
JC
Izpisúa Belmonte
D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D016228:Endothelial Growth Factors / Q000235:genetics*; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008648:Mesoderm / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D042643:Vascular Endothelial Growth Factor D
D016228:Endothelial Growth Factors; D042643:Vascular Endothelial Growth Factor D