[Effect of mexidol, emoxypine, and dimephosphon on electrophysiological effects of nibentan].
Mexidol, emoxypine, and dimephosphon decrease the acute toxicity of nibentan in mice. In the experiments on cats, these drugs reduced the negative dromotropic action of nibentan and prevented an increase in the effective refractory period of the atrioventricular node and ventricles, in the QT interval length, and in the ventricular excitation threshold.
Kotliarov
A A
AA
Department of Clinical Therapy, Mordvinian State University, ul. Ul'yanova 26, Saransk, Mordvinia, 430003 Russia.
Kurkina
N V
NV
Smirnova
L E
LE
Balykova
L A
LA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D001549:Benzamides / Q000494:pharmacology* / Q000633:toxicity; D004347:Drug Interactions; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000502:physiology; D007928:Lethal Dose 50; D051379:Mice; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000633:toxicity; D010847:Picolines / Q000494:pharmacology* / Q000633:toxicity; D023382:Toxicity Tests, Acute
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D001549:Benzamides; D009943:Organophosphorus Compounds; D010847:Picolines; C049638:dimephosphon; C070020:emoxypine succinate; C105049:nibentan; C009820:6-methyl-2-ethyl-3-hydroxypyridine