Short report: absence of protective neutralizng antibodies to West Nile virus in subjects following vaccination with Japanese encephalitis or dengue vaccines.
Protection of individuals against West Nile (WN) encephalitis is an emerging concern in the United States and Europe. We investigated whether immunization with licensed inactivated Japanese encephalitis (JE) vaccine or experimental live attenuated dengue vaccines resulted in induction of cross-neutralizing antibodies against WN virus. Protective neutralizing antibody titers to WN virus were not detected in any volunteer despite successful immunization to related flaviviruses. Vaccination against JE or dengue is unlikely to prevent WN virus infection but may still protect against disease.
Kanesa-Thasan
N
N
Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA,. niranjan.kanesa-thasan@det.amedd.army.mil
Putnak
J R
JR
Mangiafico
J A
JA
Saluzzo
J E
JE
Ludwig
G V
GV
D000914:Antibodies, Viral / Q000097:blood*; D003429:Cross Reactions; D003716:Dengue Virus / Q000276:immunology*; D005060:Europe / Q000453:epidemiology; D006801:Humans; D022321:Japanese Encephalitis Vaccines; D014481:United States / Q000453:epidemiology; D014765:Viral Vaccines; D014901:West Nile Fever / Q000453:epidemiology / Q000517:prevention & control*; D014902:West Nile virus / Q000276:immunology* / Q000302:isolation & purification
D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines; D014765:Viral Vaccines