Cellular and molecular mechanisms of carcinogenesis.
Our understanding of the cellular and molecular mechanisms of cancer of the gastrointestinal tract has increased dramatically over the last several decades. We are identifying new players in the pathways toward cancer with increasing frequency. In addition, we have come to understand that no single pathway acts by itself; in vivo, the effects are combinatorial. As new and better cell culture and animal models of carcinogenesis arise, our knowledge will continue to grow. As we learn more, we will be able to translate the results of our research into new and better techniques for the diagnosis and treatment of gastrointestinal cancers.
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd., Philadelphia, PA 19104-6144, USA.
Jonathan P
JP
Katz
Klaus H
KH
Kaestner
D017209:Apoptosis / Q000502:physiology; D020137:Base Pair Mismatch / Q000235:genetics; D002453:Cell Cycle / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology*; D019175:DNA Methylation; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D016158:Genes, p53 / Q000502:physiology; D011905:Genes, ras / Q000502:physiology; D006657:Histones / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism
D004268:DNA-Binding Proteins; D006657:Histones; D011518:Proto-Oncogene Proteins; D016212:Transforming Growth Factor beta