Therapeutic use of interleukin-2 in HIV-infected patients.
Highly active antiretroviral therapy has improved the morbidity and survival of patients with the human immunodeficiency virus (HIV) infection. Currently available antiretroviral agents can suppress viral replication and partially reverse cellular immunity defects in HIV patients. Immune-based therapy with interleukin-2 when used as adjunctive therapy to antiretroviral therapy may further improve immune responses, as demonstrated by an increase in CD4(+) T-lymphocyte counts in recent clinical trials.
Pau
Alice K
AK
National Institutes of Health, Clinical Center Pharmacy Department, Building 10, Room 1N257, Bethesda, Maryland 20892, USA. apau@nih.gov
Tavel
Jorge A
JA
D000818:Animals; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology / Q000627:therapeutic use*
D007376:Interleukin-2