The role of soy phytoestrogens in prostate cancer.
Epidemiological data of phytoestrogens and prostate cancer strongly supports the cancer protective effects of isoflavones found in soy products. Inhibition of cell proliferation via hormone-dependent and hormone-independent mechanisms by soy phytochemicals has been studied extensively in cell culture and animal studies. Herein, we review the current literature on the epidemiology and effects of two soy phytoestrogens, genistein and daidzein, and would stress the need for controlled human trials to assess the true preventive and therapeutic effects of these compounds.
Castle
Erik P
EP
Department of Surgery, Division of Urology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. erikcastle@hotmail.com
Thrasher
J Brantley
JB
D000818:Animals; D004195:Disease Models, Animal; D004968:Estrogens, Non-Steroidal / Q000032:analysis / Q000627:therapeutic use*; D019833:Genistein / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D048789:Phytoestrogens; D028321:Plant Preparations; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D013025:Glycine max / Q000737:chemistry
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; C004742:daidzein; D019833:Genistein; D017430:Prostate-Specific Antigen