Top-SUMO wrestles centromeric cohesion.
Sister chromatid cohesion at the centromere is distinct from cohesion at the chromosome arms. In the June issue of Molecular Cell, Bachant et al. have shown that centromeric cohesion in budding yeast is specifically regulated by SUMO-1 modification of Topoisomerase II.
Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, A2-168, Seattle, WA 98109, USA.
Benjamin A
BA
Pinsky
Sue
S
Biggins
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D002503:Centromere / Q000378:metabolism*; D020090:Chromosome Segregation / Q000502:physiology*; D004250:DNA Topoisomerases, Type II / Q000235:genetics / Q000378:metabolism*; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D025842:SUMO-1 Protein / Q000235:genetics / Q000378:metabolism*; D004718:Saccharomycetales / Q000166:cytology / Q000378:metabolism*
D025842:SUMO-1 Protein; D010450:Endopeptidases; C416522:Smt3-specific isopeptidase 1; D004250:DNA Topoisomerases, Type II