Effects on the reactive oxygen species of erdosteine and its metabolite in vitro.
Erdosteine (CAS 84611-23-4) and its active metabolite (M1) decrease the luminol-dependent chemiluminescence (LDCL). In this study, the scavenging effects of erdosteine and M1 on each reactive oxygen species, hypochlorous acid (HOCl), hydrogen peroxide (H2O2) and superoxide anion (O2-), were investigated. M1 interacted with HOCl at high activity, whereas erdosteine exhibited low activity. Although erdosteine interacted with H2O2 only at 1 mmol/l, M1 could significantly decrease H2O2 (> 0.1 mmol/l). Erdosteine and M1 did not interact with O2-. These results suggest that M1 possesses scavenging activities against H2O2 and HOCl in vitro.
Pharmaceutical Research & Development Center, Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan. hosoe@kyowa.co.jp
Hisashi
H
Hosoe
Toshihiko
T
Kaise
Kenji
K
Ohmori
D000111:Acetylcysteine / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry; D006997:Hypochlorous Acid / Q000737:chemistry; D007700:Kinetics; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides / Q000737:chemistry; D013864:Thioglycolates / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D013864:Thioglycolates; D013876:Thiophenes; D013481:Superoxides; D006997:Hypochlorous Acid; C048498:erdosteine; D006861:Hydrogen Peroxide; D005978:Glutathione; D000111:Acetylcysteine