Anti-Hu antibodies in Merkel cell carcinoma.
Anti-Hu antibody is an antineuronal autoantibody found in a subset of patients with paraneoplastic neurological disease. The antibody was first associated with small cell carcinoma of the lung and is most often used as a marker for this neoplasm in patients presenting with suspected paraneoplastic syndromes. Here we report a patient with a multifaceted neurological disorder in the setting of Merkel cell carcinoma. The patient's serum contained antibodies against the Hu antigen, and the expression of the Hu antigen was demonstrated in the patient's tumor.
Neurology Service, Veterans Affairs Medical Center and Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84148, USA. jgreenlee@pol.net
John E
JE
Greenlee
John D
JD
Steffens
Susan A
SA
Clawson
Kenneth
K
Hill
Josep
J
Dalmau
D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000032:analysis* / Q000097:blood; D015266:Carcinoma, Merkel Cell / Q000097:blood / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D051959:ELAV Proteins; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D009419:Nerve Tissue Proteins / Q000097:blood / Q000276:immunology*; D016601:RNA-Binding Proteins / Q000097:blood / Q000276:immunology*; D051381:Rats; D012878:Skin Neoplasms / Q000097:blood / Q000737:chemistry / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies; D051959:ELAV Proteins; D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins