Pathologic features of early inflammatory bowel disease.
Often the pathologic changes of IBD are subtle and may not be present in a proportion of biopsy specimens. In cases of early disease, the changes may be missed, and additional specimens should be taken after a period of time. Modifying factors, such as prebiopsy treatment and coexisting disease, should be considered. A forum to review cases and allow for communication between gastroenterologists and pathologists is especially useful for clinicopathologic correlation and assignment of a working diagnosis to each case. Careful attention to the pathologic features of early UC and CD would be most useful when evaluating new therapies for IBD.
Finkelstein
Sydney D
SD
Department of Pathology, Division of Gastroenterology, Nutrition and Hepatology, University of Pittsburgh Medical Center, 200 Lothrop Street, PUH A610.2, Pittsburgh, PA 15213, USA.
Sasatomi
Eizaburo
E
Regueiro
Miguel
M
D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000473:pathology*
D015415:Biomarkers