A case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement.
OBJECTIVE
To report a case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement. Lichen planus and lupus erythematosus infrequently coexist in the same patients. Ocular involvement has rarely been reported for both diseases.


METHODS
We describe a case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement. Histopathologic and immunofluorescent studies were done on buccal, lip, left conjunctival, malar, auricular and scalp lesions. The immunopathologic features of the conjunctiva, buccal mucosa and lip were consistent with lichen planus, while those of the malar, auricular and scalp lesions favoured lupus erythematosus.


RESULTS
The patient was successfully treated with hydroxychloroquine 200 mg/day and all lesions responded to therapy within weeks.


CONCLUSIONS
This is a rare example of two coexisting autoimmune disease entities: lichen planus of the oral mucosa, lip, eyelid and discoid lupus erythematosus of the skin. To our knowledge, this is the first reported case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement.
Department of Dermatology, Faculty of Medicine, Mersin University, Turkey. utursen@mersin.edu.tr
U
U
Tursen
O
O
Oz
G
G
Ikizoglu
T I
TI
Kaya
D
D
Dusmez
D000328:Adult; D003879:Dermatologic Agents / Q000627:therapeutic use; D005141:Eyelid Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008010:Lichen Planus / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013577:Syndrome
D003879:Dermatologic Agents; D006886:Hydroxychloroquine