An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids.
3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench". This technique was further studied and evaluated on other aryl halides in the preparation of arylboronic acids.
Li
Wenjie
W
Process Research Department, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. wenjie_li@merck.com
Nelson
Dorian P
DP
Jensen
Mark S
MS
Hoerrner
R Scott
RS
Cai
Dongwei
D
Larsen
Robert D
RD
Reider
Paul J
PJ