Role of ionic transport in regulation of hemoglobin affinity for oxygen in diabetes mellitus.
The rate of Na(+)/H(+) exchange is increased by 24%, activities of Ca-dependent K+ channels is increased by 13%, and activity of erythrocyte Ca(2+)-ATPase decreased by 17% in patients with diabetes mellitus concomitant with essential hypertension in comparison with patients with essential hypertension without disorders of carbohydrate metabolism. Changes in activity of Na(+)/H(+) exchange, Ca-dependent K(+) channels, and erythrocyte Ca(2+)-ATPase and increased oxygen affinity of hemoglobin are due to increased glucose concentration in the plasma and are leveled by olifen.
Biological Faculty, M. V. Lomonosov Moscow State University.
N V
NV
Maksimova
A V
AV
Nagovitsyn
G V
GV
Maksimov
D000252:Calcium-Transporting ATPases / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D017136:Ion Transport; D010100:Oxygen / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers / Q000097:blood; D013057:Spectrum Analysis
D006454:Hemoglobins; D017923:Sodium-Hydrogen Exchangers; D000252:Calcium-Transporting ATPases; D010100:Oxygen