Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history: findings from the Japan collaborative cohort study for evaluation of cancer risk.
We evaluated the associations of such lifestyle factors as alcohol drinking, coffee consumption and medical history with risk of death from pancreatic cancer in a large-scale prospective cohort study [the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC study)] in Japan. Subjects were 110,792 (46,465 men and 64,327 women) inhabitants who were enrolled from 45 areas throughout Japan. At baseline, a self-administered questionnaire was used to obtain information on lifestyle factors and medical history. Cox proportional hazard models were used to calculate relative risks. During the follow-up period (mean +/- SD 8.1 +/- 1.8 years), 225 deaths due to pancreatic cancer were identified. Overall, neither alcohol nor coffee intake was associated with risk of death from pancreatic cancer. Heavy coffee consumption (> or =4 cups/day), however, may increase the risk. Men who reported a history of diabetes mellitus and women who reported a history of gallstone/cholecystitis were at significantly (2-fold) increased risk of death from pancreatic cancer.
Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.
Yingsong
Y
Lin
Akiko
A
Tamakoshi
Takashi
T
Kawamura
Yutaka
Y
Inaba
Shogo
S
Kikuchi
Yutaka
Y
Motohashi
Michiko
M
Kurosawa
Yoshiyuki
Y
Ohno
D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D002764:Cholecystitis / Q000150:complications; D002769:Cholelithiasis / Q000150:complications; D003069:Coffee / Q000009:adverse effects*; D015331:Cohort Studies; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000401:mortality*; D016016:Proportional Hazards Models; D012307:Risk Factors; D012727:Sex Characteristics; D011795:Surveys and Questionnaires
D003069:Coffee