Taenia crassiceps: androgen reconstitution of the host leads to protection during cysticercosis.
The effects of testosterone, dihydrotestosterone, and 17beta-estradiol in castrated mice of both sexes infected with Taenia crassiceps cysticerci were studied. The results showed that castration and treatment with either testosterone or dihydrotestosterone before infection decreased parasite loads by 50 and 70%, respectively, while the treatment with 17beta-estradiol increased it by three times in both genders, as compared with control mice. The specific splenocyte cell proliferation and IL-2 and IFN-gamma production were depressed in infected-castrated mice of both genders, while treatment with testosterone or dihydrotestosterone produced a significant proliferation recovery and enhanced production of IL-2 and IFN-gamma. On the other hand, the humoral response was unaffected with testosterone or dihydrotestosterone restitution, while the treatment with estradiol in both genders augmented the levels of anti-cysticerci IgG, as well as IL-6 and IL-10 production. These results suggest a protective role for androgens, possibly through the stimulation of the specific cellular immunity.
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, U.N.A.M., AP 70228, México D.F. 04510, Mexico. jmontor66@hotmail.com
J
J
Morales-Montor
S
S
Baig
C
C
Hallal-Calleros
R T
RT
Damian
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D002369:Castration; D003551:Cysticercosis / Q000276:immunology*; D003552:Cysticercus / Q000254:growth & development / Q000276:immunology*; D013196:Dihydrotestosterone / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood / Q000502:physiology*; D005260:Female; D007111:Immunity, Cellular / Q000502:physiology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012727:Sex Characteristics; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood / Q000502:physiology*
D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D007376:Interleukin-2; D015850:Interleukin-6; D013196:Dihydrotestosterone; D016753:Interleukin-10; D013739:Testosterone; D004958:Estradiol; D007371:Interferon-gamma