No evidence for an association between the 5-hydroxytryptamine 5-HT2a receptor gene and schizophrenia in Kuwaiti Arabs.
The prevalence of T102C polymorphism of the 5-hydroxytryptamine 5-HT2a receptor gene has been investigated using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 80 Kuwaiti Arabs with schizophrenia and in 109 normal healthy controls with a similar ethnic background. There was no significant difference in the frequency of T102 polymorphism in the Kuwaiti cohort of schizophrenia patients and the controls (P = 0.23). The data from Kuwaiti Arabs (although our sample size is relatively small) support the findings from some other populations (Caucasians, Japanese), in which a lack of association has been found between T102C polymorphism and the onset of schizophrenia.
Haider
Mohammad Z
MZ
Clinical Genetics Group, Pediatrics Department, Kuwait University and Hospital for Psychological Medicine, Kuwait. haider@hsc.kuniv.edu.kw
Zahid
Mohammad A
MA
D000328:Adult; D000368:Aged; D018912:Arabs; D005260:Female; D006801:Humans; D007730:Kuwait; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin