Trichosetin, a novel tetramic acid antibiotic produced in dual culture of Trichoderma harzianum and Catharanthus roseus Callus.
The dual culture of Trichoderma harzianum and Catharanthus roseus callus produced an antimicrobial compound with a remarkable activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Structural elucidation revealed that this compound, which we have named trichosetin, is a novel tetramic acid (2,4-pyrrolidinedione) antibiotic and a homolog of the fungal metabolite equisetin. This compound however, was not produced in the individual culture of T. harzianum or C. roseus callus.
Marfori
Eufrocinio C
EC
Department of Biotechnology, Graduate School of Engineering, Osaka University, Japan.
Kajiyama
Shin'ichiro
S
Fukusaki
Ei-ichiro
E
Kobayashi
Akio
A
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D030008:Catharanthus / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009172:Mycology / Q000379:methods; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013764:Tetrahydronaphthalenes; D014242:Trichoderma / Q000502:physiology*; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C465303:trichosetin; C024509:equisetin