Expanded spectrum of recombinant human growth hormone therapy.
The efficacy of recombinant human growth hormone in the treatment of growth hormone deficiency is well established. In recent years, the use of recombinant human growth hormone as a therapeutic modality has greatly increased and has expanded beyond the realm of replacement for growth hormone deficiency. Recombinant human growth hormone has been employed to ameliorate growth failure in multiple other disorders. For some, like Turner syndrome, recombinant human growth hormone has become the standard of care. For others, the ultimate benefit of recombinant human growth hormone remains to be determined. Although recent investigations provide encouraging short-term data, it is important to recognize that the impact of recombinant human growth hormone therapy on adult height has not been established in a number of conditions.
Henwood
Maria J
MJ
Division of Pediatric Endocrinology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA.
Grimberg
Adda
A
Moshang
Thomas
T
D000328:Adult; D001827:Body Height / Q000187:drug effects; D002648:Child; D006130:Growth Disorders / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use*
D011994:Recombinant Proteins; D019382:Human Growth Hormone