[Long-acting isosorbide dinitrate and molsidomin in the treatment of effort angina in patients with arterial hypotension].
OBJECTIVE
To compare effectiveness and tolerance of isosorbide dinitrate (ID) and molsidomin in retard forms in patients with effort angina (EA) in combination with arterial hypotension (AH).


METHODS
A randomised blind cross-over trial with lead-in placebo period trial compared efficiency of retard ID and molsidomin in 65 EA patients with AH (group 1) and 40 normotensive patients with coronary heart disease (group 2).


RESULTS
Bicycle exercise has shown that retard ID and molsidomin retard were highly effective in group 1 (97% vs 92% 0 and group 2 (100 and 95%, respectively). Molsidomin retard treatment improved myocardial perfusion and was effective for a year in both groups.


CONCLUSIONS
Retard ID was highly effective in anginal patients with AH but its tolerance is also high. Molsidomin retard is proposed as alternative treatment in anginal patients with AH.
E M
EM
Idrisova
E A
EA
Kladieva
N V
NV
Borovkova
E V
EV
Vorob'eva
V I
VI
Chernov
R S
RS
Karpov
D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000009:adverse effects / Q000627:therapeutic use*; D008981:Molsidomine / Q000009:adverse effects / Q000627:therapeutic use*; D009123:Muscle Hypotonia / Q000150:complications*; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
D014665:Vasodilator Agents; D008981:Molsidomine; D007548:Isosorbide Dinitrate