Effect of subchronic ethanol treatment on plasma and cerebrospinal fluid leptin levels in rats selectively bred for high and low alcohol preference.
The effect of 5-week voluntary ethanol (EtOH) intake on plasma and cerebrospinal fluid (CSF) leptin levels was determined in adult male Warsaw high EtOH preferring (WHP) and low preferring (WLP) rats. EtOH treatment led to a decrease in leptin CSF concentration in WHP rats when compared to EtOH-naive WHP and control Wistar rats. On the contrary, in EtOH-treated WLP rats, both plasma and CSF leptin levels were increased in comparison with EtOH-naive animals. It can be concluded that EtOH treatment led to different response expressed especially by CSF leptin levels in WHP and WLP animals and it may be related to their genetic predisposition.
Mikołajczak
Przemysław
P
Department of Pharmacology, K. Marcinkowski University of Medical Sciences, Poznań, Poland. aspm@usoms.poznan.pl
Okulicz-Kozaryn
Irena
I
Kamińska
Ewa
E
Wiktorowicz
Krzysztof
K
Leśniewska
Kinga
K
Dyr
Wanda
W
Kostowski
Wojciech
W
D000428:Alcohol Drinking / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*; D000437:Alcoholism / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D020738:Leptin / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D020738:Leptin; D000431:Ethanol