Neural development: axon regeneration derailed by dendrites.
Maturing neurons gradually lose the ability to regenerate axons. In the retina, signals from neighboring cells have been found to induce a perinatal switch from extension of axons to extension of dendrites, a change that may contribute to regeneration failure.
Department of Neurobiology and Anatomy, University of Utah, School of Medicine, 20 North 1900 East, Salt Lake City 84132-3401, USA.
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D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D020813:Receptor, trkB / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism / Q000502:physiology*
D016326:Extracellular Matrix Proteins; D007797:Laminin; D019253:Proto-Oncogene Proteins c-bcl-2; D000242:Cyclic AMP; D020813:Receptor, trkB