[A new cause of postoperative confusion syndrome: nefopam].
We report a case of nefopam intoxication in a severely malnourished postoperative intensive care patient with profound hypoprotidemia. Nefopam induced agitation and confusion associated with anticholinergic symptoms such as tremor, hypertonia, mydriasis, and tachycardia. All these symptoms disappeared after withdrawal of the drug. Nefopam should be considered as a possible cause of confusion in postoperative patients.
Service d'anesthésie-réanimation, hôpital Tenon, 4, rue de la Chine, 75970 Paris, France.
A
A
Godier
A
A
Babinet
S
S
el Metaoua
J P
JP
Fulgencio
F
F
Bonnet
D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D003221:Confusion / Q000209:etiology* / Q000523:psychology*; D003422:Critical Care; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications / Q000601:surgery; D008875:Middle Aged; D009340:Nefopam / Q000009:adverse effects*; D009748:Nutrition Disorders / Q000150:complications / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology* / Q000523:psychology*
D018712:Analgesics, Non-Narcotic; D009340:Nefopam