Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/microl.
After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.
Mussini
Cristina
C
Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy.
Bugarini
Roberto
R
Perno
Carlo Federico
CF
Antinori
Andrea
A
Borghi
Vanni
V
Bertoli
Ada
A
D'Arrigo
Roberta
R
Bedini
Andrea
A
Mongiardo
Nicola
N
Cossarizza
Andrea
A
Esposito
Roberto
R
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D005260:Female; D005838:Genotype; D006678:HIV / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D009154:Mutation / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis; D013997:Time Factors; D019562:Viral Load
D019380:Anti-HIV Agents; D012367:RNA, Viral; D019259:Lamivudine