Antioxidant constituents from Setaria viridis.
The EtOAc and n-BuOH soluble fractions from the aerial part of Setaria vindis showed a strong free radical scavenging activity. Six major compounds were isolated from these fractions. They were identified by spectral data as tricin (1), p-hydroxycinnamic acid (2), vitexin 2''-O-xyloside (3), orientin 2''-O-xyloside (4), tricin-7-O-beta-D-glucoside (5) and vitexin 2"-O-glucoside (6). Among these compounds, 4 and 5 exhibited strong free radical scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH). We further studied the effects of these isolated compounds on the lipid peroxidation in rat liver microsomes induced by non-enzymatic method. As expected, 4 and 5 exhibited significant inhibition on ascorbic/Fe2+ induced lipid peroxidation in rat liver microsomes.
College of Pharmacy, Kangwon National University, Chuncheon, Korea.
Yong Soo
YS
Kwon
Eun Young
EY
Kim
Won Jun
WJ
Kim
Woo Kyung
WK
Kim
Chang Min
CM
Kim
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006868:Hydrolysis; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010851:Picrates / Q000737:chemistry; D006109:Poaceae / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010851:Picrates; D012997:Solvents; C004931:1,1-diphenyl-2-picrylhydrazyl