Noise-induced compensation for postural hypotension in primary autonomic failure.
Noise can have a beneficial effect on sensory neurological systems, enhancing detection of small afferent signals and thereby improve efferent neural responses. We hypothesized whether a similar mechanism would facilitate impaired neural transmission associated with neurological disease, and tested whether addition of external noise to baroreceptor signaling could improve blunted autonomic efferent responses to a postural challenge in patients with primary autonomic failure (PAF). Five PAF patients were tested, one in duplicate and another triplicate, for their transient responses of heart rate (measured from electrocardiographic RR intervals; RRIs) and systolic (SBP) and diastolic (DBP) blood pressures to either 30 degrees or 60 degrees head-up tilt, with and without continuous application of beat-to-beat Gaussian white noise to the carotid sinus baroreceptors. Also, the effects of noise were compared with those by a continuous positive pressure applied to the carotid sinus baroreceptors. The data were fit to a first order model to evaluate the speed (by the time constant; tau) and the magnitudes (by the steady state gains; Gs) of RRI and blood pressure responses. The PAF patients exhibited marked drops in SBP and DBP and a blunted increase in heart rate upon transition from a supine to a head-up position. Addition of noise, not the continuous positive pressure, to the arterial baroreceptors significantly (P<0.05) increased the G in RRI and diminished the Gs in SBP and DBP, though the time courses (taus) of both the RRI and blood pressure responses were unaffected. The addition of external noise to baroreceptor signaling ameliorated the marked postural hypotension seen in patients with PAF.
Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. yamamato@p.u-tokyo.ac.jp
Yoshiharu
Y
Yamamoto
Ichiro
I
Hidaka
Noriko
N
Iso-o
Akira
A
Komai
Rika
R
Soma
Shin
S
Kwak
D000222:Adaptation, Physiological; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D002346:Carotid Sinus / Q000503:physiopathology; D003971:Diastole; D005260:Female; D006339:Heart Rate; D006706:Homeostasis; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009622:Noise; D011187:Posture / Q000502:physiology; D011311:Pressoreceptors / Q000503:physiopathology; D011312:Pressure; D016683:Supine Position; D013599:Systole