Common perinatal insults diminish cord blood RANTES.
We demonstrate that the cord blood RANTES concentrations are reduced in full-term newborns who were born from meconium-stained amniotic fluid as compared with full-term newborns born after normal delivery. Since RANTES inhibits immunodeficiency virus (HIV) entry into macrophages, thereby bestowing increased resistance to HIV (including protection in utero), we propose that common perinatal events might precipitate higher perinatal transmission of HIV.
Dekel
Benjamin
B
Department of Pediatric Intensive Care, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Rubinstein
Marina
M
Mazkeret
Ram
R
Lotan
Danny
D
Paret
Gideon
G
D000653:Amniotic Fluid; D018932:Chemokine CCL2 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000097:blood; D008470:Meconium; D011247:Pregnancy; D011446:Prospective Studies
D018932:Chemokine CCL2; D018946:Chemokine CCL5; D016209:Interleukin-8