The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.
We identified the genes encoding the AcrA-AcrB-TolC efflux pump in Enterobacter aerogenes and constructed acrAB and tolC mutants from a multidrug-resistant isolate. Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant.
Pradel
Elizabeth
E
INSERM CJF9606-EA2197, IFR48, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France. elizabeth.pradel@medecine.univ-mrs.fr
Pagès
Jean-Marie
JM
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D021902:Enterobacter aerogenes / Q000187:drug effects* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial / Q000235:genetics; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D010641:Phenotype; D010957:Plasmids
D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C073126:tolC protein, E coli