Intraventricular haemorrhage in a fetus with cerebral cytomegalovirus infection.
Cytomegalovirus (CMV) is the leading infectious cause of prenatal neurological damage, which is particularly severe when primary maternal infection occurs during the first 16 weeks of gestation, at the time of organ development and neuronal migration. Vascular involvement has been suggested to be among the possible pathogenic mechanisms of virus-induced pathology, in addition to direct viral effects. We report on a fetus with cerebral CMV infection, which had intraventricular haemorrhage, together with oligohydramnios and hyperechogenic bowel, following maternal primary CMV infection.
2nd Institute of Gynecology and Obstetrics and Pediatric Institute, La Sapienza University, Rome, Italy. nigrogio@libero.it
Giovanni
G
Nigro
Renato
R
La Torre
Eleonora
E
Sali
Maura
M
Auteri
Manuela
M
Mazzocco
Luca
L
Maranghi
Erich
E
Cosmi
D000015:Abnormalities, Multiple / Q000209:etiology / Q000473:pathology; D000328:Adult; D002552:Cerebral Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000821:virology; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000503:physiopathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000473:pathology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007410:Intestinal Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D007422:Intestines / Q000002:abnormalities / Q000000981:diagnostic imaging; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000473:pathology; D016104:Oligohydramnios / Q000209:etiology / Q000473:pathology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal
D004279:DNA, Viral