A new method to produce macropores in calcium phosphate cements.
A new way to create macropores in calcium phosphate cements has been developed. The method consists in adding NaHCO3 to the starting cement powder (Biocement D) and using two different liquids: first a basic liquid to form the paste and later an acid liquid to obtain CO2 bubbles. Mercury intrusion measurements showed a dramatic increase both in macropores with an average size of 100 m and in the total porosity (even higher than 50% with respect to the Biocement D). This method does not change in any significant way the final reaction products of the starting material after being soaked 3 days in Ringer solution. Only, due to the increase of the porosity. the compressive strength of the porous cement decreases significantly.
del Real
R P
RP
Facultad de Farmacia, Departamento de Química Inorgánica y Bioinorgánica, Madrid, Spain.
Wolke
J G C
JG
Vallet-Regí
M
M
Jansen
J A
JA
D001673:Biodegradation, Environmental; D001843:Bone Cements; D002130:Calcium Phosphates; D019245:Compressive Strength; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D014961:X-Ray Diffraction
D001843:Bone Cements; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous