Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment.
Deletion of both copies of the Nf1 gene in Schwann cells combined with Nf1 heterozygosity in the tumor environment promotes neurofibroma formation in mice.
McLaughlin
Margaret E
ME
Howard Hughes Medical Institute, Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
Jacks
Tyler
T
D000818:Animals; D002471:Cell Transformation, Neoplastic; D017353:Gene Deletion; D016514:Genes, Neurofibromatosis 1 / Q000502:physiology*; D006801:Humans; D019656:Loss of Heterozygosity; D051379:Mice; D008822:Mice, Transgenic; D009455:Neurofibroma / Q000235:genetics*; D012583:Schwann Cells / Q000378:metabolism