CO-induced K(+) currents in rat glomus cells are insensitive to light unlike carotid body neural discharge and Vo(O(2)).
The hypothesis that the light sensitive properties of CO-induced chemosensory nerve (CSN) discharge and oxygen consumption of the carotid body (CB) were shared by the pre-synaptic glomus cells was tested. The light effect on K(+) currents were measured before and during perfusion of the isolated rat glomus cells with high P(CO) of 550 Torr during nomoxia (P(O(2)approximately equal 100 Torr) at extra-cellular pH 7.0 and intracellular pH 6.8 with HEPES buffer. CO increased the K(+) currents with a left ward shift of the reversal potential, which showed no light effect. Thus the K(+) permeability of the glomus cell membrane were not shared by the light-sensitive CSN discharge of the CB and oxygen consumption in the presence of high P(CO.)
Department of Physiology, University Pennsylvania School of Medicine, B400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA.
Jinqing
J
Li
Arijit
A
Roy
Anil
A
Mokashi
Sukhamay
S
Lahiri
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism*; D002344:Carotid Body / Q000166:cytology / Q000502:physiology* / Q000528:radiation effects*; D002346:Carotid Sinus / Q000294:innervation; D002628:Chemoreceptor Cells / Q000378:metabolism; D066298:In Vitro Techniques; D008027:Light; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013569:Synapses / Q000502:physiology
D002245:Carbon Dioxide; D011188:Potassium; D010100:Oxygen