Lauric acid is desaturated to 12:1n-3 by hepatocytes and rat liver homogenates.
Lauric acid desaturation was investigated and described in liver homogenates and in cultured rat hepatocytes. The identification of the desaturated product of lauric acid has been performed using the oxidative cleavage method, and we showed that the obtained monoene was mainly 12:1n-3. This result suggests that lauric acid desaturation could be the first step in the biosynthesis of alpha-linolenic acid in animal cells.
Legrand
Philippe
P
Laboratoire de Biochimie INRA-ENSA, Rennes, France. Philippe.Legrand@agrorennes.educagri.fr
Catheline
Daniel
D
Rioux
Vincent
V
Durand
Georges
G
D000818:Animals; D002478:Cells, Cultured; D022781:Hepatocytes / Q000378:metabolism*; D007850:Lauric Acids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013230:Stearoyl-CoA Desaturase
D007850:Lauric Acids; C030358:lauric acid; D013230:Stearoyl-CoA Desaturase