Validity of urinalysis and microscopy for detecting urinary tract infection in the emergency department.
This study assessed the validity of standard urinalysis, urinalysis for leucocyte esterase and nitrites, and urgent microscopy in the diagnosis of urinary tract infection (UTI) in 60 female patients with a triage diagnosis of UTI. There were 24 (40%) proven UTIs after culture. Simple urinalysis was sensitive for UTI (95.8%) but the positive predictive value was only 45.1%. The addition of leucocyte esterase and nitrite urinalysis testing did not improve the sensitivity, but if both of these were positive the positive predictive value improved to 100%. Urgent microscopy alone was sensitive (100%) but non-specific (38.9%). The specificity of the diagnosis improved to 94.4% for organism counts of >or=10/microl and to 88.9% for leucocyte counts of >or=50/microl. The negative predictive value of no detectable leucocytes on microscopy was 94.7%. Screening for UTI in the emergency department (ED) population is improved by the addition of leucocyte esterase and nitrite test. A positive urinalysis test for leucocytes and nitrites, or urinalysis positive at levels of >or=500 leucocytes or >or=5 g/l protein should confirm a clinical diagnosis of UTI. Urgent urine microscopy should be performed only if the above criteria are not met yet a minimum of one urinalysis result is positive.
Accident and Emergency Department, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.
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Leman
D000328:Adult; D002265:Carboxylic Ester Hydrolases / Q000652:urine; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008853:Microscopy; D009573:Nitrites / Q000652:urine; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014218:Triage / Q000379:methods; D016482:Urinalysis / Q000592:standards*; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000382:microbiology; D014556:Urine / Q000382:microbiology
D009573:Nitrites; C021443:leukocyte esterase; D002265:Carboxylic Ester Hydrolases