Comparison of the efficacy of early versus late viral proteins in vaccination against SIV.
The immune response against early regulatory proteins of simian- and human immunodeficiency virus (SIV, HIV) has been associated with a milder course of infection. Here, we directly compared vaccination with Tat/Rev versus Pol/Gag. Challenge infection with SIVmac32H (pJ5) suggested that vaccination with Tat/Rev induced cellular immune responses that enabled cynomolgus macaques to more efficiently control SIV replication than the vaccine-induced immune responses against Pol/Gag. Vaccination with Tat/Rev resulted in reduced plasma SIV loads compared with control (P=0.058) or Pol/Gag-vaccinated (P=0.089) animals, with undetectable plasma viral loads in two of the four Tat/Rev-vaccinated animals. Therefore, the results warrant further investigation of the early regulatory proteins and their potential for vaccination against HIV.
Department of Virology, Erasmus Medical Centre Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
Koert J
KJ
Stittelaar
Rob A
RA
Gruters
Martin
M
Schutten
Carel A
CA
van Baalen
Geert
G
van Amerongen
Martin
M
Cranage
Peter
P
Liljeström
Gerd
G
Sutter
Albert D M E
AD
Osterhaus
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D001483:Base Sequence; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology; D015684:Gene Products, pol / Q000235:genetics / Q000276:immunology; D015694:Gene Products, rev / Q000235:genetics / Q000276:immunology; D015696:Gene Products, tat / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008252:Macaca fascicularis; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D018449:SAIDS Vaccines / Q000235:genetics / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D014766:Viremia / Q000276:immunology / Q000517:prevention & control / Q000821:virology
D000914:Antibodies, Viral; D015683:Gene Products, gag; D015684:Gene Products, pol; D015694:Gene Products, rev; D015696:Gene Products, tat; D012367:RNA, Viral; D018449:SAIDS Vaccines