Successful outcome of liver transplantation in a patient with hepatitis C and common variable immune deficiency.
A 43-year-old man with common variable immune deficiency underwent liver transplantation for cirrhosis caused by hepatitis C virus (HCV). HCV had been acquired from a contaminated batch of immunoglobulin. He developed cirrhosis within 3 years of infection with the virus, then liver failure requiring liver transplantation. The immediate post-transplant course was uncomplicated. Five months after transplantation he developed liver failure, and the histological appearances were those of severe cholestatic hepatitis. Withdrawal of immunosuppression resulted in recovery from liver failure. Clearance of the HCV from serum was also observed and has been sustained during follow-up (despite the subsequent reintroduction of low-dose immunosuppression). The patient is alive and well more than 5 years after transplantation. His post-transplant course has been remarkable for the aggressive recurrence then clearance of the HCV.
Liver and Hepatobiliary Unit, Third Floor, Nuffield House, Queen Elizabeth Hospital, Birmingham B15 2TH, UK.
Paul J
PJ
Gow
David
D
Mutimer
D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications*; D006526:Hepatitis C / Q000150:complications* / Q000601:surgery*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D011183:Postoperative Complications / Q000821:virology; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents