Prolactin as an autocrine/paracrine growth factor in human cancer.
Prolactin (PRL) has a dual function -- as a circulating hormone and as a cytokine. This understanding is based on PRL production and distinct regulation in extrapituitary sites, its binding to membrane receptors of the cytokine receptor superfamily, and activation of signaling pathways that promote cell growth and survival. There is increasing evidence that PRL plays a role in several types of cancer in reproductive and non-reproductive tissues via local production or accumulation. The expression of both PRL and its receptor in human cancer cell lines of diverse origin lends further support to its action as an autocrine/paracrine growth factor. Establishment of PRL as an active participant in tumorigenesis should inspire the development of novel therapies aimed at reducing tumor growth by suppressing PRL production or by blocking its receptors.
Department Cell Biology, University of Cincinnati Medical School, Cincinnati, OH 45267, USA. nira.ben-jonathan@uc.edu
Nira
N
Ben-Jonathan
Karen
K
Liby
Molly
M
McFarland
Michael
M
Zinger
D000818:Animals; D017209:Apoptosis; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division; D005260:Female; D006133:Growth Substances; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000473:pathology*; D010902:Pituitary Gland / Q000378:metabolism; D011388:Prolactin / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000473:pathology; D011981:Receptors, Prolactin / Q000502:physiology; D015398:Signal Transduction
D006133:Growth Substances; D011981:Receptors, Prolactin; D011388:Prolactin