Apoptosis-inducing activity of synthetic intermediates of halichlorine.
Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.
Institute for Medicinal Resources, University of Tokushima, Sho-machi 1-78, 770-8505, Tokushima, Japan.
Midori
M
Itoh
Jun
J
Kuwahara
Kohji
K
Itoh
Yu ichi
Yi
Fukuda
Mikiko
M
Kohya
Mitsuru
M
Shindo
Kozo
K
Shishido
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3; D053179:Caspase 7; D020169:Caspases / Q000378:metabolism; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D002843:Chromatin; D013141:Spiro Compounds; C412666:halichlorine; C505407:CASP3 protein, human; C505520:CASP7 protein, human; D053148:Caspase 3; D053179:Caspase 7; D020169:Caspases