TH1/TH2 balance in the subretinal fluid of patients with rhegmatogenous retinal detachment.
BACKGROUND
The pathogenesis of rhegmatogenous retinal detachments remains unclear, but some data suggest immune system involvement. Cytokines are substances secreted by cells in order to modulate the function of other cells. They exert primarily local effects. Because the TH1/TH2 balance is crucial in the immune response, the predominance of one cytokine profile in subretinal fluid may be of particular importance in understanding its pathogenesis.


METHODS
We measured the titres of IL-10 and tIL-12 in the subretinal fluid of 36 rhegmatogenous retinal detachment patients using ELISA assays.


RESULTS
The mean level of IL-10 and tIL-12 in the subretinal fluid was 4.75 pg/ml and 106.5 pg/ml, respectively.


CONCLUSIONS
It would appear that IL-10 and IL-12 are produced by cells in subretinal fluid, and their presence may be evidence for an existing inflammatory process. Despite the tendency to decreased cytokine concentration over time and the tendency to higher concentrations of IL-10 and tIL-12 when the detachment of the retina is more extensive, no predominance of TH1- or TH2-type response was observed.
2nd Department of Ophthalmology, Medical University, Lublin, Poland.
Maria
M
Lewandowska-Furmanik
Dorota
D
Pozarowska
Piotr
P
Pozarowski
Anna
A
Matysik
D000293:Adolescent; D000328:Adult; D000368:Aged; D005122:Exudates and Transudates / Q000166:cytology / Q000276:immunology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016753:Interleukin-10; D018664:Interleukin-12