Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study.
OBJECTIVE
Gamma-linolenic acid (GLA) is known to be cytotoxic to malignant cells. We assessed the efficacy of the novel intravesical formulation, meglumine gamma-linolenic acid (MeGLA), in a phase II trial, in patients with recurrent, superficial bladder cancer.


METHODS
Thirty patients with recurrent, superficial transitional cell carcinoma (TCC) were recruited. The tumour pattern was recorded at flexible cystoscopy. Patients received a single intravesical instillation of 50ml of either 50mg (1mg/ml) (15 patients), or 125mg (2.5mg/ml) (15 patients) of MeGLA in water, retained for one hour. At subsequent cystoscopy, the tumour patterns were recorded, prior to undertaking routine cystodiathermy. Biopsies were obtained for histological assessment. Responses were divided into complete, partial or none.


RESULTS
All 30 patients retained the drug for 1 hour without significant local or systemic side effects. There were 4 (13%) complete responses, 9 (30%) partial responses, and 17 (57%) non-responders. Histology showed no evidence of damage to surrounding urothelium.


CONCLUSIONS
Our data confirms the safety and tolerability of MeGLA, which is consistent with findings from a previous phase I trial. A response rate of 43% also indicates that MeGLA has a significant cytotoxic effect against TCC and the results are similar to those obtained using standard, single-dose, intravesical regimens.
Harris
N M
NM
Solent Department of Urology, St. Mary's Hospital NHS Trust, Portsmouth, UK. neilandjane@supanet.com
Crook
T J
TJ
Dyer
J P
JP
Solomon
L Z
LZ
Bass
P
P
Cooper
A J
AJ
Birch
B R
BR
D000283:Administration, Intravesical; D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000473:pathology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008536:Meglumine / Q000627:therapeutic use*; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017965:gamma-Linolenic Acid / Q000627:therapeutic use*
D004338:Drug Combinations; D008536:Meglumine; D017965:gamma-Linolenic Acid