Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies.
In this chapter, the recent advances in cartilage biomechanics and electromechanics are reviewed and summarized. Our emphasis is on the new experimental techniques in cartilage mechanical testing, new experimental and theoretical findings in cartilage biomechanics and electromechanics, and emerging theories and computational modeling of articular cartilage. The charged nature and depth-dependent inhomogeneity in mechano-electrochemical properties of articular cartilage are examined, and their importance in the normal and/or pathological structure-function relationships with cartilage is discussed, along with their pathophysiological implications. Developments in theoretical and computational models of articular cartilage are summarized, and their application in cartilage biomechanics and biology is reviewed. Future directions in cartilage biomechanics and mechano-biology research are proposed.
Mow
Van C
VC
Department of Biomedical Engineering, Columbia University New York, New York 10027, USA. vcm1@columbia.edu
Guo
X Edward
XE
D016880:Anisotropy; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000737:chemistry* / Q000502:physiology*; D019245:Compressive Strength / Q000502:physiology; D004548:Elasticity; D004563:Electrochemistry; D008954:Models, Biological; D008956:Models, Chemical; D016062:Porosity; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D016474:Weight-Bearing