Role of influenza A virus hemagglutinin in neurovirulence for mammalians.
Influenza viruses with potential neuroinvasiveness for humans emerged in Hong Kong in 1997. Prophylactic and therapeutic strategies are urgently needed for controlling the central nervous system complications caused by influenza. Here we review recent advances toward understanding of the possible mechanisms of the neuropathogenesis of influenza virus infection, especially focusing on the role of viral hemagglutinin glycoprotein.
Mori
Isamu
I
Department of Microbiology, Fukui Medical University School of Medicine, Japan. ykimura@fmsrsa.fukui-med.ac.jp
Yokochi
Takashi
T
Kimura
Yoshinobu
Y
D000293:Adolescent; D020816:Amino Acid Motifs; D000818:Animals; D001717:Birds; D002493:Central Nervous System Diseases / Q000821:virology*; D002645:Chickens; D004671:Encephalitis, Arbovirus / Q000453:epidemiology; D005260:Female; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics / Q000378:metabolism*; D006389:Hemagglutinins, Viral / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007251:Influenza, Human / Q000821:virology*; D029521:Alphainfluenzavirus / Q000145:classification / Q000472:pathogenicity* / Q000502:physiology; D008297:Male; D008322:Mammals; D051379:Mice; D014774:Virulence
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; C452559:hemagglutinin HA-2 fusogenic peptide, Influenza virus