Development of a strong cation-exchange high-performance liquid chromatography method for analysis of isoaspartate in proteins.
Zhang
Wei
W
Wyeth BioPharma, Genetics Institute Campus, Andover, MA 01810, USA. wei.zhang@immunogen.com
Czupryn
Marta J
MJ
D002411:Cation Exchange Resins; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D026581:Isoaspartic Acid / Q000032:analysis*; D000432:Methanol / Q000032:analysis* / Q000378:metabolism; D008745:Methylation; D010446:Peptide Fragments / Q000737:chemistry; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase / Q000737:chemistry* / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000737:chemistry
D002411:Cation Exchange Resins; D026581:Isoaspartic Acid; D010446:Peptide Fragments; D012436:S-Adenosylmethionine; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase; D000432:Methanol