Effects of Melilotus officinalis on acute inflammation.
Our study investigated the effects of Melilotus officinalis L. extract, containing 0.25% coumarin, on acute inflammation induced with oil of turpentine in male rabbits. The results were compared with those from a group treated with hydrocortisone sodium hemisuccinate and one injected with coumarin before inflammation was induced. The effects were evaluated by measuring serum citrulline, a test of in vitro phagocytosis, total leukocyte count and differential leukocyte count expressed as a percentage. M. officinalis had antiinflammatory effects because it reduced the activation of circulating phagocytes and lowered citrulline production. These properties were similar to those of hydrocortisone sodium hemisuccinate and coumarin. In the bone marrow acute phase response, M. officinalis had an inhibitory action that was lower than that of hydrocortisone sodium hemisuccinate and similar to coumarin.
Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Luminiţa
L
Pleşca-Manea
Alina Elena
AE
Pârvu
M
M
Pârvu
M
M
Taămaş
R
R
Buia
M
M
Puia
D000210:Acute-Phase Reaction; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002956:Citrulline / Q000097:blood; D003374:Coumarins / Q000494:pharmacology; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D007958:Leukocyte Count; D008297:Male; D029903:Melilotus / Q000737:chemistry*; D009569:Nitric Oxide / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018514:Plant Structures / Q000737:chemistry; D011817:Rabbits; D014425:Turpentine / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D003374:Coumarins; D010936:Plant Extracts; D002956:Citrulline; D009569:Nitric Oxide; C030123:coumarin; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone; D014425:Turpentine