Metastable epialleles in mammals.
There are some mammalian alleles that display the unusual characteristic of variable expressivity in the absence of genetic heterogeneity. It has recently become evident that this is because the activity of these alleles is dependent on their epigenetic state. Interestingly, the epigenetic state is somewhat labile, resulting in phenotypic mosaicism between cells (variegation) and also between individuals (variable expressivity). The establishment of the epigenetic state occurs during early embryogenesis and is a probabilistic event that is influenced by whether the allele is carried on the paternal or maternal alleles. In addition, the epigenetic state determines whether these alleles are dominant. We propose that mammalian alleles with such characteristics should be termed metastable epialleles to distinguish them from traditional alleles. At this stage, it is unclear how common these alleles are, but an appreciation of their existence will aid in their identification.
School of Molecular and Microbial Biosciences, University of Sydney, NSW-2006, Sydney, Australia.
Vardhman K
VK
Rakyan
Marnie E
ME
Blewitt
Riki
R
Druker
Jost I
JI
Preis
Emma
E
Whitelaw
D000483:Alleles; D000818:Animals; D005799:Genes, Dominant; D018392:Genomic Imprinting; D008322:Mammals / Q000235:genetics*; D051379:Mice; D018626:Retroelements; D019076:Transgenes
D018626:Retroelements