Changes in motion vs. bonding in positively vs. negatively cooperative interactions.
From a consideration of the interactions between non-covalent bonds, it is concluded that positively cooperative binding will occur with a benefit in enthalpy and a cost in entropy, and that negatively cooperative binding will occur with a cost in enthalpy and a benefit in entropy; experimental data support these conclusions.
Cambridge Centre for Molecular Recognition, Dept. of Chemistry, Lensfield Road, Cambridge, UK CB2 1EW. dhwl@cam.ac.uk
Dudley H
DH
Williams
Christopher T
CT
Calderone
Dominic P
DP
O'Brien
Rosa
R
Zerella