A case of acute myeloid leukemia with t(7;11)(p15;p15) mimicking myeloid crisis of chronic myelogenous leukemia.
The chromosome aberration t(7;11)(p15;p15) is uncommon but recurrent in leukemia. We experienced a case of acute leukemia with t(7;11)(p15;p15), the hematological appearance of which mimicked myeloid crisis in chronic myeloid leukemia (CML). This case showed splenomegaly, a decreased neutrophil alkaline phosphatase (NAP) score, increased vitamin B12 value, and cells at all stages of neutrophilic maturation in both bone marrow and peripheral blood. We initially had difficulty differentiating acute myeloid leukemia (AML) M2 with marked myeloid differentiation from myeloid crisis of Philadelphia chromosome (Ph)-negative CML. Immature myeloid cells in the peripheral blood disappeared and cytogenetic analysis indicated that marrow cells changed to the normal karyotype after remission induction therapy. Therefore, this case was thought not to be myeloid crisis but AML M2 subtype. The NUP98/HOXA9 fusion transcript was detected by reverse transcription-polymerase chain reaction (RT-PCR) at exon A but not exon B of NUP98.
Division of Hematology, Suzuka General Hospital, Mie, Japan. Kawakei@cocoa.ocn.ne.jp
Keiki
K
Kawakami
Setsuko
S
Miyanishi
Kazuhiho
K
Nishii
Eiji
E
Usui
Tetsuya
T
Murata
Isaku
I
Shinsato
Hiroshi
H
Shiku
D000208:Acute Disease; D001752:Blast Crisis / Q000175:diagnosis*; D002880:Chromosomes, Human, Pair 11; D002897:Chromosomes, Human, Pair 7; D003937:Diagnosis, Differential; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic