cag+ Helicobacter pylori induces homotypic aggregation of macrophage-like cells by up-regulation and recruitment of intracellular adhesion molecule 1 to the cell surface.
Infection with cag+ but not cag-negative Helicobacter pylori leads to the formation of large homotypic aggregates of macrophage-like cells. Intracellular adhesion molecule 1 is up-regulated and recruited to the cell surface of infected cells and mediates the aggregation via lymphocyte function-associated molecule 1. This signaling may regulate cell-cell interactions and inflammatory responses.
Moese
Stefan
S
Abteilung Molekulare Biologie, Max-Planck-Institut für Infektionsbiologie, D-10117 Berlin, Germany.
Selbach
Matthias
M
Meyer
Thomas F
TF
Backert
Steffen
S
D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology*; D002449:Cell Aggregation; D002462:Cell Membrane / Q000276:immunology; D029721:Drosophila Proteins; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000382:microbiology / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020298:U937 Cells; D015854:Up-Regulation / Q000276:immunology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D029721:Drosophila Proteins; D016169:Lymphocyte Function-Associated Antigen-1; D008565:Membrane Proteins; D009687:Nuclear Proteins; C080866:cagA protein, Helicobacter pylori; C425767:vir protein, Drosophila; D018799:Intercellular Adhesion Molecule-1