Gastroprotective effect of adrenomedullin administered subcutaneously in the rat.
Subcutaneous injections of adrenomedullin prevented reserpine-induced gastric mucosal damage in a dose-dependent manner (1-1000 ng/kg), but did not interfere with the lesions produced by ethanol administration. In pylorus-ligated rats adrenomedullin significantly reduced gastric volume, total and free acid output as well as ulcer formation. The gastroprotective activity of adrenomedullin was not present in rats pretreated with cysteamine. These results suggest that adrenomedullin exerts its antiulcer effect, when it is administered subcutaneously (s.c.), probably by a mechanism which involves somatostatin related transmission.
Department of Experimental and Clinical Pharmacology, School of Medicine, University of Catania, Catania, Italy. gclemen@unict.it
Giuseppe
G
Clementi
Antonina
A
Caruso
Vincenza Maria Catena
VM
Cutuli
Nunzio Guido
NG
Mangano
Salvatore
S
Salomone
Laurence
L
Lempereur
Agata
A
Prato
Mario
M
Matera
Matilde
M
Amico-Roxas
D053607:Adrenomedullin; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003543:Cysteamine / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000293:injuries; D006863:Hydrogen-Ion Concentration; D008297:Male; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D011708:Pylorus; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000494:pharmacology; D013004:Somatostatin / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D010455:Peptides; D053607:Adrenomedullin; D000431:Ethanol; D013004:Somatostatin; D003543:Cysteamine; D012110:Reserpine