A protein-farnesyl transferase inhibitor interferes with the serum-induced conversion of Candida albicans from a cellular yeast form to a filamentous form.
A commercially available, cell permeable, protein-farnesyl transferase inhibitor interfered with the serum-induced morphological change in Candida albicans from a cellular yeast form to a filamentous form. The inhibitor has a negligible effect on the growth of C. albicans cells in the cellular yeast form, at the levels used to interfere with the morphological change. Conversion of C. albicans from the yeast form to filamentous form is associated with pathogenicity and hence protein-farnesyl transferase inhibitors are potentially of therapeutic value against C. albicans infection.
Department of Chemistry, Clark Atlanta University, 266 Lee Street, Atlanta, GA 30314, USA. pmcgeady@cau.edu
Paul
P
McGeady
David A
DA
Logan
Daniel L
DL
Wansley
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D017368:Protein Prenylation / Q000187:drug effects
D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D005656:Fungal Proteins; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase