Obesity therapy: altering the energy intake-and-expenditure balance sheet.
Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.
Crowley
Vivion E F
VE
University Departments of Medicine and Clinical Biochemistry, Addenbrooke's Hospital, Cambridge CB2 2QR, UK.
Yeo
Giles S H
GS
O'Rahilly
Stephen
S
D002001:Adipose Tissue, Brown / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology; D002149:Energy Intake; D004734:Energy Metabolism; D006801:Humans; D007028:Hypothalamic Hormones / Q000502:physiology; D020738:Leptin / Q000502:physiology; D008543:Melanins / Q000502:physiology; D009478:Neuropeptide Y / Q000502:physiology; D009765:Obesity / Q000378:metabolism / Q000628:therapy*; D010907:Pituitary Hormones / Q000502:physiology; D011333:Pro-Opiomelanocortin / Q000502:physiology; D043643:Receptor, Muscarinic M1; D011956:Receptors, Cell Surface; D018043:Receptors, Corticotropin / Q000502:physiology; D054411:Receptors, Leptin; D044101:Receptors, Melanocortin; D011976:Receptors, Muscarinic / Q000502:physiology; D011979:Receptors, Pituitary Hormone / Q000502:physiology; D014158:Transcription, Genetic
D002352:Carrier Proteins; D007028:Hypothalamic Hormones; D020738:Leptin; D008543:Melanins; D009478:Neuropeptide Y; D010907:Pituitary Hormones; D043643:Receptor, Muscarinic M1; D011956:Receptors, Cell Surface; D018043:Receptors, Corticotropin; D054411:Receptors, Leptin; D044101:Receptors, Melanocortin; D011976:Receptors, Muscarinic; D011979:Receptors, Pituitary Hormone; C092274:melanin-concentrating hormone receptor; D011333:Pro-Opiomelanocortin; C019463:melanin-concentrating hormone