Anticancer and antithrombin activity of Russian plants.
A chromogenic bioassay was utilized to determine the antithrombin activity of the methylene chloride and methanol extracts prepared from forty-five plants of Russia. Mouse leukemia cells (L1210) were utilized to screen these extracts for activity against cancer. The results indicated that eight plant extracts demonstrated 90% or higher activity in the inhibition of thrombin. Also, nine methanol extracts demonstrated activity of 90% or higher in the inhibition of mouse leukemia L1210 cells. The methanol extracts of Quercus robur and Sanguisorba officinalis demonstrated high activity against both thrombin and cancer.
Department of Chemistry, University of Central Florida, Orlando, FL 32826, USA.
Elena A
EA
Goun
V M
VM
Petrichenko
S U
SU
Solodnikov
T V
TV
Suhinina
Martin A
MA
Kline
Glenn
G
Cunningham
Chi
C
Nguyen
Howard
H
Miles
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D007938:Leukemia / Q000473:pathology*; D000432:Methanol; D008752:Methylene Chloride; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry* / Q000145:classification; D012426:Russia; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000925:Anticoagulants; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D008752:Methylene Chloride; D013917:Thrombin; D000432:Methanol