Therapeutic strategies for human amyloid diseases.
Amyloid diseases are a large group of a much larger family of misfolding diseases. This group includes pathologies as diverse as Alzheimer's disease, immunoglobulin-light-chain disease, reactive amyloid disease and the familial amyloid polyneuropathies. These diseases are generally incurable at present, although some drugs are known to transiently slow the progression of Alzheimer's disease. As we increase our understanding of the causative mechanisms of these disorders, the likelihood of success for a given therapeutic strategy will become clearer. This review will look at small-molecule and macromolecular approaches for intervention in amyloid diseases other than Alzheimer's disease, although select examples from Alzheimer's disease will be discussed.
Sacchettini
James C
JC
Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, Texas 77843-2128, USA. sacchett@tamu.edu
Kelly
Jeffery W
JW
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000209:etiology; D000682:Amyloid / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D028227:Amyloid Neuropathies, Familial; D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007114:Immunization; D012307:Risk Factors
D000682:Amyloid