Viral load response to a pneumococcal conjugate vaccine, polysaccharide vaccine or placebo among HIV-infected patients.
We determined the HIV viral load in 66 adults randomly assigned to receive pneumococcal immunization with one or two doses of protein conjugate vaccine, one dose of polysaccharide vaccine, one dose of each, or placebo. Second doses were given 8 weeks after the first. Mean baseline viral load and CD4 cell count were 3.41 copies/ml (log10) and 457 cells/microl, respectively. We found no change in viral load during 24 weeks of follow-up for any vaccine or combination of vaccines or placebo.
VA Greater Los Angeles Healthcare System and University of California Los Angeles, Los Angeles, CA, USA.
Matthew Bidwell
MB
Goetz
Daniel R
DR
Feikin
Jeffrey L
JL
Lennox
William A
WA
O'Brien
Cheryl M
CM
Elie
Jay C
JC
Butler
Robert F
RF
Breiman
D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000328:Adult; D018791:CD4 Lymphocyte Count; D005500:Follow-Up Studies; D015658:HIV Infections / Q000628:therapy / Q000821:virology*; D006801:Humans; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000008:administration & dosage; D019562:Viral Load
D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate