Coexistence of pseudoxanthoma elasticum-like papillary dermal elastolysis and linear focal dermal elastosis.
An 89-year-old Japanese woman had pseudoxanthoma elasticum-like papillary dermal elastolysis on the neck and linear focal elastosis on the flexor aspects of the legs and thighs. The lesions of both diseases had similar histologic patterns-loss of elastic fibers in the papillary dermis and accumulation of normal-appearing elastic fibers in the subpapillary or mid dermis. Immunohistochemical analysis showed elastin, and microfibril-associated proteins (fibrillin 1 and 2 and microfibril associated glycoprotein 1 and 4) were absent or decreased in the papillary dermis and present in the accumulated elastic fibers in both lesions. The association of 2 diseases on different areas of the same patient and histologic and immunohistologic similarities between the diseases suggest that, despite the clinical differences, both diseases are closely related.
Akagi
Atsushi
A
Department of Dermatology, National Defense Medical College, Saitama, Japan.
Tajima
Shingo
S
Kawada
Akira
A
Ishibashi
Akira
A
D000368:Aged; D000369:Aged, 80 and over; D003240:Connective Tissue Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D003285:Contractile Proteins / Q000378:metabolism; D004547:Elastic Tissue / Q000378:metabolism / Q000473:pathology*; D004548:Elasticity; D005260:Female; D006801:Humans; D011561:Pseudoxanthoma Elasticum / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000473:pathology
D003285:Contractile Proteins