Efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivative, a selective agonist for human peroxisome proliferator-activated receptor alpha.
An optically active phenylpropanoic acid derivative, a selective agonist for human peroxisome proliferator-activated receptor alpha, was efficiently prepared in high optical purity by using Evans chiral oxazolidinone technique as a key step.
Nomura
Masahiro
M
Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 2399-1Mitarai, Nogi-machi, Shimotsuga-gun, 329-0114, Tochigi, Japan.
Tanase
Takahiro
T
Miyachi
Hiroyuki
H
D006801:Humans; D015394:Molecular Structure; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*
D010666:Phenylpropionates; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors