Baseline levels of plasma endothelin-1 (ET-1) and changes during transfusion in thalassemic patients.
We studied levels of plasma endothelin-1 (ET-1) in 25 beta-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 +/- 2.1 pg/mL vs. 8.9 +/- 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to slightly increase during the first 24 hr but significantly decline at the 7th day to levels (8.01 +/- 1.7 pg/mL) which do not differ from those of controls. This study highlights a different alteration of plasma ET-1 in patients with beta-thalassemia compared to that of patients with sickle-cell anemia.
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom. viprakas@molbiol.ox.ac.uk
Vip
V
Viprakasit
Suthida
S
Kankirawatana
Pravit
P
Akarasereenont
Kritvikrom
K
Durongpisitkul
Sirikul
S
Chotewuttakorn
Voravarn S
VS
Tanphaichitr
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006400:Hematocrit; D006446:Hemoglobin E / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D017086:beta-Thalassemia / Q000097:blood* / Q000628:therapy*
D019332:Endothelin-1; D006454:Hemoglobins; D006446:Hemoglobin E