Development of insulin resistance in experimental animals during long-term glucocorticoid treatment.
Long-term treatment with glucocorticoids led to the development of insulin resistance in experimental animals, which was confirmed by a progressive increase in blood insulin level and decrease in the glucose/insulin index. The comparative study showed that hydrocortisone produced more pronounced and rapid changes than dexamethasone. However, we found no differences in the glucose/insulin index by the 23rd day of treatment with these hormones.
Laboratory of Endocrinology, Research Center for Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. ccem@cyber.ma.nsc.ru
V G
VG
Selyatitskaya
O I
OI
Kuz'minova
S V
SV
Odintsov
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007328:Insulin; D003907:Dexamethasone