Intravenous anesthetic, propofol inhibits invasion of cancer cells.
Intravenous anesthetic, propofol (2,6-diisopropylphenol), is extensively used for general anesthesia without knowing the effects on cancer. We found here that clinically relevant concentrations of propofol (1-5 microg/ml) decreased the invasion ability of human cancer cells (HeLa, HT1080, HOS and RPMI-7951). In the HeLa cells treated with propofol, formation of actin stress fibers as well as focal adhesion were inhibited, and propofol had little effect on the invasion ability of the HeLa cells with active Rho A (Val(14)-Rho A). In addition, continuous infusion of propofol inhibited pulmonary metastasis of murine osteosarcoma (LM 8) cells in mice. These results suggest that propofol inhibits the invasion ability of cancer cells by modulating Rho A and this agent might be an ideal anesthetic for cancer surgery.
Mammoto
Tadanori
T
Department of Anesthesiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3, Nakamichi, Higashinari, Osaka 537-8511, Japan. tada@qb4.so-net.ne.jp
Mukai
Mutsuko
M
Mammoto
Akiko
A
Yamanaka
Yasutsugu
Y
Hayashi
Yukio
Y
Mashimo
Takashi
T
Kishi
Yoshihiko
Y
Nakamura
Hiroyuki
H
D000199:Actins / Q000378:metabolism; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D051379:Mice; D009361:Neoplasm Invasiveness / Q000517:prevention & control*; D012516:Osteosarcoma / Q000473:pathology / Q000517:prevention & control / Q000556:secondary; D015742:Propofol / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000199:Actins; D018686:Anesthetics, Intravenous; D015742:Propofol