Receptor specificity of the antiarrhythmic effect produced by opioid peptides Dalargin and DADLE during myocardial reperfusion.
Nonselective agonists of mu- and delta-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of mu-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of mu-opioid receptors.
Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences. narn@cardio.tsu.ru
N V
NV
Naryzhnaya
L N
LN
Maslov
Yu B
YB
Lishmanov
G J
GJ
Gross
D000818:Animals; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D015425:Myocardial Reperfusion; D051381:Rats; D017465:Receptors, Opioid, delta / Q000187:drug effects* / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000187:drug effects* / Q000378:metabolism
D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-