Asymmetric deprotonation and dearomatising cyclisation of N-benzyl benzamides using chiral lithium amides: formal synthesis of (-)-kainic acid.
Chiral lithium amides deprotonate N-benzyl benzamides enantioselectively, initiating an asymmetric dearomatising cyclisation to enantiomerically enriched isoindolinones.
Clayden
Jonathan
J
Department of Chemistry, University of Manchester, Oxford Road, Manchester, UK M20 5LG. j.p.clayden@man.ac.uk
Menet
Christel J
CJ
Mansfield
Darren J
DJ