A new binding mode of competitive antagonists to metabotropic glutamate receptors exemplified by the mGluR1-receptor antagonist AIDA (RS-aminoindan-1,5-dicarboxylic acid).
Belenikin
M S
MS
Moscow State University, Vorob'evy gory, Moscow, 119992 Russia.
Baskin
I I
II
Palyulin
V A
VA
Zefirov
N S
NS
D001667:Binding, Competitive; D007189:Indans / Q000378:metabolism* / Q000494:pharmacology*; D007700:Kinetics; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D013816:Thermodynamics
C095756:1-aminoindan-1,5-dicarboxylic acid; D007189:Indans; D008024:Ligands; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1