Protein flexibility and drug design: how to hit a moving target.
The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.
Carlson
Heather A
HA
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065, USA. carlsonh@umich.edu
D000818:Animals; D003198:Computer Simulation; D030562:Databases, Protein; D015195:Drug Design; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
D011506:Proteins