Lethality of yeasts with low pathogenicity in mice immunocompromised by cyclophosphamide treatment.
One strain each of Arxiozyma telluris, Saccharomyces cerevisiae, and S. kluyveri showed lethal activity in cyclophosphamide (CY)-treated mice. Accumulation of these yeast cells in the kidneys and elevation of the levels of cytokines, tumor necrosis factor-alpha, and interleukin-1alpha in the sera were recognized in the CY-treated infected-debilitated mice.
Second Department of Hygienic Chemistry, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan. okawa@tohoku-pharm.ac.jp
Yoshio
Y
Okawa
Yasuyo
Y
Yamada
D000818:Animals; D015169:Colony Count, Microbial; D003520:Cyclophosphamide; D004195:Disease Models, Animal; D016867:Immunocompromised Host / Q000276:immunology*; D007375:Interleukin-1 / Q000097:blood; D007668:Kidney / Q000276:immunology / Q000382:microbiology*; D008297:Male; D051379:Mice; D009181:Mycoses / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015003:Yeasts / Q000472:pathogenicity*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D003520:Cyclophosphamide