Steroid responsive cutaneous Rosai-Dorfman disease associated with uveitis and hypothyroidism.
We report a patient with steroid responsive cutaneous Rosai-Dorfman disease (RDD) associated with bilateral anterior uveitis and hypothyroidism. RDD is a rare histiocytic disorder of unknown aetiology. There is characteristic histology in which large pale-staining histiocytes exhibit emperipolesis and stain positive for S-100 protein. This condition is thought to be a reactive process rather than a neoplastic one and viral and immune mediated causes have been postulated.
Salim
A
A
Dermatology Department, Amersham Hospital, Amersham Buckinghamshire, UK. asalim28@hotmail.com
Williamson
M
M
Barker
F
F
Hughes
J
J
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003519:Cyclopentolate / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy; D009184:Mydriatics / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D013974:Thyroxine / Q000627:therapeutic use; D014606:Uveitis, Anterior / Q000150:complications / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D009184:Mydriatics; D011239:Prednisolone; D003519:Cyclopentolate; D013974:Thyroxine