EGF receptor activation by heterologous mechanisms.
A myriad of growth factor-dependent and -independent mechanisms for activating the EGF receptor and the related ErbB receptors underscore the importance of receptor inhibitors in the treatment of some solid tumors.
Carraway
Kermit L
KL
University of California, Davis, Cancer Center, Sacramento 95817, USA. klcarraway@ucdavis.edu
Sweeney
Colleen
C
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*; D055293:Receptors, Urokinase Plasminogen Activator; D015398:Signal Transduction / Q000502:physiology*; D015854:Up-Regulation
C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D066246:ErbB Receptors