Solid-phase synthesis of apicidin A and a cyclic tetrapeptoid analogue.
The solid-phase synthesis of the antiprotozoal cyclic tetrapeptide apicidin A is reported and its synthetic accessibility is contrasted with that of a structurally similar reduced cyclic tetrapeptoid analogue.
Berst
Frédéric
F
GSK Cambridge Technology Centre, Lensfield Road, Cambridge, UK CB2 1EW.
Ladlow
Mark
M
Holmes
Andrew B
AB
D000981:Antiprotozoal Agents / Q000138:chemical synthesis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D056572:Histone Deacetylase Inhibitors; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
D000981:Antiprotozoal Agents; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D010456:Peptides, Cyclic; C102351:apicidin