Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues.
The synthesis and biological evaluation of new diadenosine polyphosphate analogues on blood platelet aggregation are reported. The most active are compounds with a sulfur atom replacing one or both non-bridging oxygens at phosphorus bound to adenosyl residues and hydroxymethyl groups of bis(hydroxymethyl)phosphinic acid.
Department of Molecular and Medical Biophysics, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland. bogdan.walkowiak@csk.am.lodz.pl
Bogdan
B
Walkowiak
Janina
J
Baraniak
Czeslaw S
CS
Cierniewski
Wojciech
W
Stec
D000241:Adenosine / Q000031:analogs & derivatives*; D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001665:Binding Sites; D015226:Dinucleoside Phosphates / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013329:Structure-Activity Relationship
D015226:Dinucleoside Phosphates; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D000241:Adenosine