Statin specific toxicity in organ transplant recipients: case report and review of the literature.
Statins are widely prescribed to organ transplant recipients with hyperlipidemia. We report the case of a cardiac transplant recipient who developed severe rhabdomyolysis and acute renal failure after being switched from pravastatin to simvastatin. The patient's other medications included cyclosporin A and diltiazem. Unlike pravastatin, the metabolism and tissue concentrations of simvastatin--and of other statins - can be greatly affected by these drugs. The propensity of the individual statins to interact with drugs commonly prescribed to transplant recipients is reviewed.
Bae
Jina
J
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jarcho
John A
JA
Denton
Mark D
MD
Magee
Colm C
CC
D058186:Acute Kidney Injury / Q000139:chemically induced*; D016027:Heart Transplantation; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000506:poisoning*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D019821:Simvastatin / Q000506:poisoning*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D017035:Pravastatin