Retrobulbar chlorpromazine injections for the management of blind and seeing painful eyes.
OBJECTIVE
To report the efficacy of primary retrobulbar chlorpromazine injections for the management of blind and seeing painful eyes.


METHODS
Retrospective case series from three university hospitals was done. Twenty eyes of 20 patients with at least 3 months of follow-up are reported. Ten of these 20 eyes did not receive any other ophthalmic medications either 2 weeks before chlorpromazine injection or at any time point after injection. Treatment was considered successful if pain control lasted for at least 3 months, without the need for reinjection or enucleation.


RESULTS
Sixteen of 20 (80.0%) eyes achieved successful pain control. There were no permanent complications in any patient.


CONCLUSIONS
Retrobulbar chlorpromazine appears to be safe and effective for the management of pain in blind eyes.
Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA. teresa_chen@meei.harvard.edu
Teresa C
TC
Chen
Sonia J
SJ
Ahn Yuen
Marither A
MA
Sangalang
Ronaldo E
RE
Fernando
Edgar U
EU
Leuenberger
D000293:Adolescent; D000328:Adult; D000368:Aged; D001766:Blindness / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D002746:Chlorpromazine / Q000008:administration & dosage / Q000627:therapeutic use*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005901:Glaucoma / Q000150:complications; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009915:Orbit; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D012189:Retrospective Studies; D012449:Safety
D018492:Dopamine Antagonists; D002746:Chlorpromazine