pH-regulated formation of amyloid-like beta-sheet assemblies from polyglutamate grafted polyallylamine.
A novel artificial protein with simple primary structure, poly(gamma-methyl-L-glutamate)-grafted polyallylamine, has been prepared and the resultant peptide has shown a unique property of pH-regulated conformation and morphology.
Nanoarchitectonics Research Center, National Institute of Advanced Industrial Science and Technology and CREST, Japan Science and Technology, Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
Tomoyuki
T
Koga
Kazuhiro
K
Taguchi
Takatoshi
T
Kinoshita
Masahiro
M
Higuchi
D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002942:Circular Dichroism; D006863:Hydrogen-Ion Concentration; D011073:Polyamines / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D011073:Polyamines; D011099:Polyglutamic Acid; C063994:polyallylamine