A new ergostanol saponin from Dioscorea deltoidea Wall var. orbiculata.
From the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculata, a novel ergostanol saponin, orbiculatoside A (1), was isolated and identified as 3-O-beta-D-glucopyranosyl-ergost-5-ene-3beta, 26-diol-26-O-beta-D-glucopyranosyl(1-->3)-[beta-D-glucopyranosyl(1-->2)-beta-D-glucupyranosyl(1-->6)]-beta-D-glucopyranoside by various NMR techniques in combination with chemical methods. The new saponin showed strong activity against Pyricularia oryzae, with a MMDC (minimum morphological deformation concentration) value of 28.04 micromol/l and was cytotoxic to cancer cell line K562, HCT-15, A549, HT1080, and A2780a in vitro.
Shen
Ping
P
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, China.
Wang
San-Long
SL
Liu
Xi-Kui
XK
Yang
Chong-Ren
CR
Cai
Bing
B
Yao
Xin-Sheng
XS
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D027742:Dioscorea; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D027343:Rhizome; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D010936:Plant Extracts; D012503:Saponins; C469766:orbiculatoside A; C007614:ergostanol; D004875:Ergosterol