Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/microl.
After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.
Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy.
Cristina
C
Mussini
Roberto
R
Bugarini
Carlo Federico
CF
Perno
Andrea
A
Antinori
Vanni
V
Borghi
Ada
A
Bertoli
Roberta
R
D'Arrigo
Andrea
A
Bedini
Nicola
N
Mongiardo
Andrea
A
Cossarizza
Roberto
R
Esposito
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D005260:Female; D005838:Genotype; D006678:HIV / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D009154:Mutation / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis; D013997:Time Factors; D019562:Viral Load
D019380:Anti-HIV Agents; D012367:RNA, Viral; D019259:Lamivudine