Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions.
We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-dose chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment, the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report, the patient has been well for more than 2 years.
Department of Biopathology Science, Graduate School of Medicine and Dentistry, Okayama University Graduate Schools, Japan. makita@d5.dion.ne.jp
Masanori
M
Makita
Yoshinobu
Y
Maeda
Katsuto
K
Takenaka
Katsuji
K
Shinagawa
Kazutaka
K
Sunami
Yasushi
Y
Hiramatsu
Nobuharu
N
Fujii
Fumihiko
F
Ishimaru
Kazuma
K
Ikeda
Kenji
K
Niiya
Tadashi
T
Yoshino
Mine
M
Harada
D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000473:pathology; D017708:Leukocyte Transfusion; D016399:Lymphoma, T-Cell / Q000628:therapy*; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine