Titanium-catalyzed enantioselective alkynylation of aldehydes.
A simple and practical method to make chiral propargylic alcohols has been developed: in the presence of a titanium alkoxide catalyst prepared in situ from titanium tetraisopropoxide and (R)-H8-binaphthol, a variety of aromatic aldehydes were converted to the corresponding chiral propargylic alcohols with very good enantioselectivities (up to 96.2% e.e.) and yields.
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong Polytechnic University, Hong Kong.
Gui
G
Lu
Xingshu
X
Li
Wing Lai
WL
Chan
Albert S C
AS
Chan