Effect of pre-operative anxiolysis on postoperative pain response in patients undergoing total abdominal hysterectomy.
In a double blind, placebo-controlled trial, we have assessed the effects of pre-operative anxiolysis on postoperative pain scores in 112 ASA I-II women, aged 18-65 years, scheduled to undergo total abdominal hysterectomy. Subjects were randomly allocated to receive either oral diazepam 10 mg (n=56) or placebo (n=56) pre-operatively. Postoperative anxiety, pain scores, analgesic consumption, and sedation were evaluated at several time points during the first 24 h following surgery. Postoperative pain scores were found to be significantly higher in the diazepam group. Trait and state anxiety showed a significant effect on pain scores, independent of the treatment group. No difference was found between the groups in morphine consumption, but there was a significant reduction in morphine consumption with time.
Anaesthesia Service, Hospital de Clínicas de Port Alegre, Universidade Federal do Rio Grande do Sul, UFRGS, Brazil. caumo@cpovo.net
W
W
Caumo
M P L
MP
Hidalgo
A P
AP
Schmidt
C W
CW
Iwamoto
L C
LC
Adamatti
J
J
Bergmann
M B C
MB
Ferreira
D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001007:Anxiety / Q000517:prevention & control; D016292:Procedural Sedation; D003975:Diazepam / Q000009:adverse effects*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000139:chemically induced* / Q000188:drug therapy; D011292:Premedication / Q000009:adverse effects*
D000701:Analgesics, Opioid; D014151:Anti-Anxiety Agents; D009020:Morphine; D003975:Diazepam