Mechanistic aspects of enzymatic carbohydrate epimerization.
Carbohydrate epimerases are enzymes that catalyze an inversion of stereochemistry at a stereogenic center in a sugar. This review focuses on the mechanistic strategies that are employed by this diverse family of enzymes, and is divided into the following sections: deprotonation/reprotonation, transient oxidation, cofactor independent, and mutarotation. The review is comprehensive up to Oct. 2001 and contains 216 references.
Samuel
Jomy
J
Department of Chemistry, University of British Columbia, Vancouver, Canada.
Tanner
Martin E
ME
D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D019998:Racemases and Epimerases / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism
D002241:Carbohydrates; D019998:Racemases and Epimerases