Head, neck, and spines: a role for LIMK-1 in the hippocampus.
LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings are consistent with a role for LIMK-1 in synapse formation and function.
Department of Biochemistry and Molecular Biology, Program in Molecular, Cellular and Integrative Neuroscience, Colorado State University, Fort Collins 80523, USA.
Patrick D
PD
Sarmiere
James R
JR
Bamburg
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D004268:DNA-Binding Proteins / Q000172:deficiency* / Q000235:genetics; D003712:Dendrites / Q000378:metabolism* / Q000473:pathology; D006624:Hippocampus / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D007859:Learning Disabilities / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D054461:Lim Kinases; D017774:Long-Term Potentiation / Q000502:physiology; D051379:Mice; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency* / Q000235:genetics; D013569:Synapses / Q000378:metabolism* / Q000473:pathology; D009435:Synaptic Transmission / Q000502:physiology
D004268:DNA-Binding Proteins; D011494:Protein Kinases; D054461:Lim Kinases; C515893:Limk1 protein, mouse; D017346:Protein Serine-Threonine Kinases