Immunohistochemical detection of P-glycoprotein (PGP) and multidrug resistance-associated protein (MRP) in canine cutaneous mast cell tumors.
Fifty-four canine cutaneous mast cell tumors were evaluated immunohistochemically for the expression of P-glycoprotein (PGP) and multidrug-resistance-associated protein (MRP). All tumors examined were graded according to the histological malignancy. ranging from grade I to III. The expression of PGP was confirmed in 15% (8/54) of whole, 33% (5/15) of grade I, 10% (3/31) of grade II, and 0% (0/8) of grade III tumors. The expression of MRP was found in 18% (10/54) of whole, 26% (4/15) of grade I, 19% (6/31) of grade II, and 0% (0/8) of grade III tumors. The cases positive to at least one of these 2 multidrug markers were 26%, 47%, 23% and 0% of whole and grade I to III tumors, respectively. These results indicate that at least 26% of canine cutaneous mast cell tumors express PGP and/or MRP and that these tumors may be resistant to several anti-cancer drugs.
Department of Veterinary Pathology, Faculty of Agriculture, Kagoshima University, Japan.
Noriaki
N
Miyoshi
Etsuko
E
Tojo
Akihiro
A
Oishi
Makoto
M
Fujiki
Kazuhiro
K
Misumi
Hiroshi
H
Sakamoto
Kazuhisa
K
Kameyama
Tsutomu
T
Shimizu
Nobuhiro
N
Yasuda
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000818:Animals; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D008415:Mastocytosis / Q000378:metabolism* / Q000473:pathology / Q000662:veterinary*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000662:veterinary*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D027425:ATP-Binding Cassette, Sub-Family C Proteins