Breast cancer masquerading as a primary gastric carcinoma.
The differentiation between primary gastric cancer and a metastatic breast tumor to the stomach is important for planning of treatment and to spare the patient unnecessary surgery. We report a rare case of breast cancer with metastasis to the stomach. The diagnosis was established by histologic and immunohistochemical analyses of biopsies of the stomach lesion using gross cystic disease fluid protein-15, cytokeratin, carcinoembryonic antigen, and epithelial membrane antigen. Positivity for gross cystic disease fluid protein-15 with negative staining for carcinoembryonic antigen supported the diagnosis of a breast cancer metastasis. The patient was treated with systemic chemotherapy without surgery and is still alive 2 years after initial referral for a gastric neoplasm.
Tremblay
Francine
F
Department of Surgery, Royal Victoria Hospital, McGill University, 687 Pine Avenue, W. Montreal H3A 1A1, Quebec, Canada.
Jamison
Bruce
B
Meterissian
Sarkis
S
D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000556:secondary* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D013274:Stomach Neoplasms / Q000556:secondary* / Q000628:therapy