Depletion of bone-marrow cells due to deficiencies of trace elements.
Male rats were divided into five diet-dependent groups: the Control group; two kinds of Zn-deficient diet groups with different amounts of Mn and Mg (the CLEA and OBS group); the Pair-fed group, where the body weight gain of the rats was restricted; and the OBS + Zn group. In those groups where the diets were deficient in Zn, Mn, and Mg, bone-marrow cells were suppressed and the peripheral reticulocyte count was decreased, but plasma corticosterone increased significantly. The OBS + Zn group demonstrated an improvement in the reticulocyte count and serum corticosterone level.
First Department of Surgery, Shiga University of Medical Science, Tsukinowa, Shiga, Japan.
Hiroshi
H
Oka
Tohru
T
Tani
Yozo
Y
Ebira
Masashi
M
Kodama
Katsuyuki
K
Nakajima
D000818:Animals; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000166:cytology* / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D008275:Magnesium Deficiency / Q000503:physiopathology*; D008297:Male; D008345:Manganese / Q000172:deficiency*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D017701:Reticulocyte Count; D014131:Trace Elements / Q000172:deficiency*; D015032:Zinc / Q000097:blood / Q000172:deficiency*
D014131:Trace Elements; D008345:Manganese; D015032:Zinc; D003345:Corticosterone