Genetic code: introducing pyrrolysine.
Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG. Initial studies suggest that pyrrolysine may be co-translationally inserted during protein synthesis, probably by a mechanism analogous to that operating during selenocysteine incorporation.
Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus 43210-1292, USA.
Michael
M
Ibba
Dieter
D
Söll
D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics; D019843:Archaeal Proteins; D003062:Codon; D019766:Genes, Archaeal; D008239:Lysine / Q000031:analogs & derivatives* / Q000235:genetics*; D017021:Methanosarcina barkeri / Q000201:enzymology* / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics*; D014176:Protein Biosynthesis
D019843:Archaeal Proteins; D003062:Codon; D008780:Methyltransferases; C113200:monomethylamine methyltransferase; D000604:Amino Acyl-tRNA Synthetases; C456839:pyrrolysine; D008239:Lysine