[The effect of uridine and uridine nucleotides on isolated rat heart performance in regional myocardial ischemia].
We studied the effects of uridine, uridine-5'-monophosphate (UMP), uridine-5'-diphosphate (UDP) and uridine-5'-triphosphate on contractility, coronary flow and heart rate in isolated perfused rat hearts under 60-minute regional ischemia of the left ventricle. All the compounds (50 mumol/l) induced a positive inotropic effect but had no effect on the heart rate. Uridine and UMP prevented the development of the contracture. UDP and especially UTP increased coronary flow. Probably, a protective effect of uridine and UMP is due to activation of myocardial glycogen synthesis while favourable effects of UDP and UTP on contractility and coronary flow are explained by their influence on P2U-receptors of cardiomyocytes. In addition, coronary dilatation induced by UDP and UTP promoted the reduction of the damaged zone.
Eliseev
V V
VV
Rodionova
O M
OM
Sapronov
N S
NS
Selizarova
N O
NO
D000818:Animals; D016880:Anisotropy; D003326:Coronary Circulation / Q000187:drug effects; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D014500:Uracil Nucleotides / Q000378:metabolism / Q000494:pharmacology*; D014529:Uridine / Q000494:pharmacology*
D014500:Uracil Nucleotides; D014529:Uridine