title: [Genetics of lymphedema: from Milroy's disease to cancer investigations].
abstract: New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. Above all, new focus on lymphatic endothelial cells gives opportunities for developing innovative therapies for lymphedema and cancer metastasis.
authors.affiliation: Service de médecine interne et maladies vasculaires, hôpital Saint-Eloi, 2, avenue Bertin-Sans, 34295 Montpellier, France. i-quere@chu-montpellier.fr
authors.forename: I
authors.initials: I
authors.lastname: Quéré
authors.forename: M
authors.initials: M
authors.lastname: Coupé
authors.forename: V
authors.initials: V
authors.lastname: Soulier-Sotto
authors.forename: M
authors.initials: M
authors.lastname: Evrard-Bras
authors.forename: J P
authors.initials: JP
authors.lastname: Laroche
authors.forename: C
authors.initials: C
authors.lastname: Janbon
mesh_terms: D016228:Endothelial Growth Factors / Q000235:genetics* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008196:Lymph; D008209:Lymphedema / Q000235:genetics* / Q000503:physiopathology*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000150:complications; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D
chemical_list: D016228:Endothelial Growth Factors; D008024:Ligands; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D