title: Identification of HLA-B*1566.
abstract: A novel polymorphism was identified in a B*15 allele. B*1566 possesses a nucleotide substitution of C to G at nucleotide 272. This polymorphism encodes an amino acid difference from serine in B*1501101 to cysteine in B*1566 at residue 67. Residue 67 is a constituent of the B pocket and is situated on the alpha1 helix facing into the groove. This mutation may have arisen through interallelic recombination as it has been seen in other B*15 alleles and is also present in most B*14, B*27, B*38, B*39 alleles and in B*7301.
authors.affiliation: The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom.
authors.forename: S T
authors.initials: ST
authors.lastname: Cox
authors.forename: B
authors.initials: B
authors.lastname: Prokupek
authors.forename: F
authors.initials: F
authors.lastname: Baker
authors.forename: R
authors.initials: R
authors.lastname: Holman
authors.forename: V T C
authors.initials: VT
authors.lastname: Leung
authors.forename: A S W
authors.initials: AS
authors.lastname: Wong
authors.forename: J A
authors.initials: JA
authors.lastname: Madrigal
authors.forename: A-M
authors.initials: AM
authors.lastname: Little
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D015235:HLA-B Antigens