One-pot enantioselective formation of eight-membered rings from alkenyl Fischer carbene complexes and ketone enolates.
Eight-membered carbocycles with up to five new stereogenic centers are enantioselectively obtained following a one-pot procedure that involves the coupling of three components: an alkenyl Fischer carbene complex, a ketone enolate, and allyl lithium.
Barluenga
José
J
Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería, 8, E-33071 Oviedo, Spain. barluenga@sauron.quimica.uniovi.es
Diéguez
Alejandro
A
Rodríguez
Félix
F
Flórez
Josefa
J
Fañanás
Francisco J
FJ