Antisense RNA in imprinting: spreading silence through Air.
In some animals, including mammals, a number of genes are expressed differently according to whether they have been inherited from the mother or from the father, through a process known as genomic imprinting. Noncoding RNAs have increasingly been found associated with imprinted genes, but their role, if any, has remained enigmatic. A recent study provides the first evidence that, at least in one case, a noncoding RNA has a direct role in regulating imprinted gene expression in cis.
Rougeulle
Claire
C
Unité de Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France. rougell@pasteur.fr
Heard
Edith
E
D000818:Animals; D005786:Gene Expression Regulation; D020868:Gene Silencing; D018392:Genomic Imprinting; D006801:Humans; D051379:Mice; D016372:RNA, Antisense / Q000235:genetics*; D017527:Receptor, IGF Type 2 / Q000235:genetics
D016372:RNA, Antisense; D017527:Receptor, IGF Type 2