[Intranasal vaccination with live measles vaccines within the framework of measles eradication strategy].
The authors discuss the possibility of intranasal revaccination with live measles vaccine. Intranasal vaccination is no less effective than subcutaneous. It induces generalized immune response and formation of anti-measles IgA in the nasopharyngeal mucosa. Immunomodulating side effects of intranasal vaccination are less pronounced than those of subcutaneous one. The intranasal method of vaccination is safer than the inhalation method, which involves exposure of the bronchial mucosa to the live measles virus. The efficiency of mucosal measles vaccine can be increased by adding this or that adjuvant to the vaccine.
Liashchenko
V A
VA
Iuminova
N V
NV
D000281:Administration, Intranasal; D006801:Humans; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014611:Vaccination
D008458:Measles Vaccine