Molecular events in skeletal muscle during disuse atrophy.
This review summarizes the current knowledge of the molecular processes underlying skeletal muscle atrophy due to disuse. Because the processes involved with muscle wasting due to illness are similar to disuse, this literature is used for comparison. Areas that are ripe for further study and that will advance our understanding of muscle atrophy are suggested.
Kandarian
Susan C
SC
Department of Health Sciences, Boston University, Massachusetts 02215, USA. skandar@bu.edu
Stevenson
Eric J
EJ
D000818:Animals; D002100:Cachexia / Q000235:genetics; D003546:Cysteine Endopeptidases / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D009097:Multienzyme Complexes / Q000378:metabolism; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D009133:Muscular Atrophy / Q000235:genetics; D016328:NF-kappa B / Q000235:genetics; D046988:Proteasome Endopeptidase Complex; D025801:Ubiquitin / Q000378:metabolism; D014481:United States
D009097:Multienzyme Complexes; D016328:NF-kappa B; D025801:Ubiquitin; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex
NASA Discipline Musculoskeletal; Non-NASA Center