Antimicrobial diterpenes from the stem bark of Mitrephora celebica.
Four diterpenes were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Ent-trachyloban-19-oic acid (1) and ent-kaur-16-en-19-oic acid (2) were identified as the compounds responsible for the antimicrobial activity of the plant against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis. 8(14),15-pimaradien-18-oic acid (3) and 7,15-pimaradien-18-oic acid (4) were isolated from the same fraction and were inactive against the microorganisms.
Zgoda-Pols
J R
JR
Graduate Program in Pharmacognosy, Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, 600 South 43rd Street, PA Philadelphia 19104-4495, USA.
Freyer
A J
AJ
Killmer
L B
LB
Porter
J R
JR
D029061:Annonaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D007214:Indonesia; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts; D018547:Plant Stems / Q000737:chemistry*
D000890:Anti-Infective Agents; D004224:Diterpenes; D010936:Plant Extracts