Acridine derivatives as chemotherapeutic agents.
Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial and antiprotozoal agents. Some work in these areas continues, but recent research has focused mainly on their use as anticancer drugs, because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase enzymes.
Denny
William A
WA
Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, Private Bag 92019, New Zealand. b.denny@auckland.ac.nz
D000166:Acridines / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000166:Acridines; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D007364:Intercalating Agents; D004247:DNA