[Endogenous dopamine modulates cortico-pallidal influence via GABA].
Sprague-Dawley rats were used to study the influence of local application of antagonists of D1 and D2 receptors (SCH 23390 and raclopride, respectively) on neuronal responses in globus pallidus evoked by somatosensory cortex stimulation. SCH 23390 was found to produce a short-latency inhibition in response to cortical stimulation and to block the long-latency inhibition. Raclopride application suppressed the short-latency inhibition and revealed the long-latency inhibition in response to cortical stimulation. It is suggested that the observed phenomena are based on the modulation of GABA releasing in stria-pallidar terminals by endogenous dopamine.
Raevskiĭ
V V
VV
Institute of Higher Nervous Activity and Neurophysiology of the Russian Acad. Sci., Russia, 117485, Moscow, Butlerov St., 5a.
Dawe
G S
GS
Stevenson
J D
JD
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects / Q000502:physiology*; D005917:Globus Pallidus / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D020891:Raclopride / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001552:Benzazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D020891:Raclopride; D005680:gamma-Aminobutyric Acid; D004298:Dopamine