Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection.
Antiviral therapy induces a rapid drop in human immunodeficiency virus type 1 viremia, but the decline of virus levels decelerates over time. Mathematical modeling demonstrates that the source of residual virus production might be a single compartment of latently infected cells with an extended distribution of activation rates.
Müller
Viktor
V
Ecology and Evolution, ETH Zürich, 8092 Zürich, Switzerland. mueller@eco.umnw.ethz.ch
Vigueras-Gómez
Javier Flavio
JF
Bonhoeffer
Sebastian
S
D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D013997:Time Factors; D014775:Virus Activation; D017735:Virus Latency; D014779:Virus Replication