title: Comparison of two T-classification systems for sino-nasal carcinoma.
abstract: It is often difficult to determine the actual site of origin of tumours originating in the sino-nasal region, and a uniform classification system that covers all tumours in this area is warranted. A retrospective series of 165 consecutive patients with sino-nasal carcinoma, treated and followed at the Aarhus University Hospital between 1963 and 1991, was evaluated and T-staged according to the Lederman classification. The 80 maxillary antrum carcinomas were also staged according to the UICC 1997 system. In univariate analysis, the UICC T-classification was prognostic for locoregional tumour control and disease-specific survival. However, when adjusted for covariates (gender and nodal involvement) in a multivariate analysis, the UICC classification was not a significant independent prognostic parameter. In contrast, the Lederman T-classification was prognostic both in univariate and multivariate analysis. The Lederman T-classification was more prognostic for locoregional control and disease-specific survival than the UICC TNM classification. In addition, the Lederman classification is easy to use and has a broader applicability as it covers all sites in the sino-nasal area.
authors.affiliation: Department of Head and Neck Surgery, Aarhus University Hospital, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Harbo
authors.forename: T
authors.initials: T
authors.lastname: Bundgaard
authors.forename: J
authors.initials: J
authors.lastname: Overgaard
authors.forename: C
authors.initials: C
authors.lastname: Grau
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000145:classification* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009669:Nose Neoplasms / Q000145:classification* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000145:classification* / Q000473:pathology; D011379:Prognosis