title: Subcortical hyperintensities in Alzheimer's disease: associated clinical and metabolic findings.
abstract: The authors measured subcortical hyperintensities (SH) on magnetic resonance images (MRI) in 18 patients with probable Alzheimer's disease and examined the relationships of SH severity with cortical metabolic function and clinical symptoms. Severity of SH was not correlated with absolute metabolic rates in cortical lobes. However, anterior SH severity was inversely correlated with frontal/ parietal metabolic ratios after covarying for cognitive impairment. SH severity in some areas was associated with the severity of global neuropsychiatric symptoms, but marked effects on individual symptoms were not apparent. The small sample size and multiple variables limit conclusions that can be drawn. These preliminary findings indicate that subcortical MRI hyperintensities may play a role in the pathophysiology and clinical expression of Alzheimer's disease.
authors.affiliation: Departments of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles, USA. dsultzer@ucla.edu
authors.forename: David L
authors.initials: DL
authors.lastname: Sultzer
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Chen
authors.forename: Charles V
authors.initials: CV
authors.lastname: Brown
authors.forename: Michael E
authors.initials: ME
authors.lastname: Mahler
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Cummings
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hinkin
authors.forename: Mark A
authors.initials: MA
authors.lastname: Mandelkern
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology* / Q000523:psychology; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010296:Parietal Lobe / Q000378:metabolism / Q000473:pathology; D018709:Statistics, Nonparametric