Fresh osteochondral allografts.
Fresh osteochondral allografts have a long clinical history and have demonstrated use in a wide spectrum of knee joint pathology. The allografting procedure takes advantage of the unique characteristics of osseous and chondral tissue components. Transplanted bone is readily incorporated by the host while the articular cartilage survives transplantation. Allografts have demonstrated >75% clinical success in the treatment of focal femoral condyle lesions due to trauma, chondral injury, osteochondral trauma, osteochondritis dissecans, avascular necrosis, and post-traumatic reconstruction. Fresh allografts also are finding an increasing role in the salvage of difficult cases that have failed other cartilage procedures, and particularly in individuals who are believed to be too young and active for joint arthroplasty. Further refinements in the technical aspects of the allografting procedure, as well as further understanding of the biology of osteochondral allografts, should lead to improved clinical outcomes.
Bugbee
William D
WD
Department of Orthopedics, University of California-San Diego, La Jolla 92037, USA.
D016025:Bone Transplantation; D002356:Cartilage / Q000637:transplantation*; D005269:Femur / Q000503:physiopathology / Q000601:surgery; D006084:Graft Rejection; D006801:Humans; D007717:Knee / Q000601:surgery*; D007718:Knee Injuries / Q000601:surgery*; D009926:Organ Preservation / Q000379:methods; D010008:Osteochondritis Dissecans / Q000601:surgery; D010329:Patella / Q000503:physiopathology / Q000601:surgery; D013977:Tibia / Q000601:surgery; D014019:Tissue Donors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D016896:Treatment Outcome