Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study.
In osteoarthritis (OA) the balance between cartilage degeneration and repair is disturbed. The aim of this pilot clinical study was to examine the effects of a nonsteroidal anti-inflammatory drug, nimesulide, on the synthesis of matrix metalloproteinases (MMPs) which are important enzymes in cartilage proteolysis. Cartilage oligomeric matrix protein (COMP), a component of the extracellular matrix, was used as an indicator of accelerated joint erosion. Radiologically proven painful OA of the knee or hip was treated with 100 mg nimesulide twice daily for 3 weeks. MMP-1, -3 and -8 and COMP were measured by immunoassays, and clinical investigations were made on pain, and on disease intensity using the WOMAC scale. During treatment with nimesulide, in addition to clinical improvement and less pain, serum levels of MMP-3, MMP-8 and COMP fell indicating a beneficial effect on cartilage catabolism.
Kullich
W C
WC
Ludwig Boltzmann Institute for Rehabilitation of Internal Diseases, Saalfelden, Austria.
Niksic
F
F
Klein
G
G
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D064236:Cartilage Oligomeric Matrix Protein; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D005109:Extracellular Matrix / Q000187:drug effects* / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000097:blood; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D064235:Matrilin Proteins; D020782:Matrix Metalloproteinases / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy* / Q000378:metabolism; D015207:Osteoarthritis, Hip / Q000188:drug therapy / Q000378:metabolism; D020370:Osteoarthritis, Knee / Q000188:drug therapy / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000378:metabolism; D010865:Pilot Projects; D018709:Statistics, Nonparametric; D013449:Sulfonamides / Q000627:therapeutic use*
D064236:Cartilage Oligomeric Matrix Protein; D016861:Cyclooxygenase Inhibitors; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D013449:Sulfonamides; C577553:TSP5 protein, human; D020782:Matrix Metalloproteinases; C012655:nimesulide