Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration.
Ebbs
A
A
Fujisawa Research Institute of America, 1801 Maple Avenue, Evanston, IL 60201, USA.
Pan
F
F
Wynn
C
C
Erickson
L
L
Kobayashi
M
M
Jiang
H
H
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000517:prevention & control*; D053804:Granzymes; D016027:Heart Transplantation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016753:Interleukin-10 / Q000037:antagonists & inhibitors*; D008562:Membrane Glycoproteins / Q000032:analysis; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012697:Serine Endopeptidases / Q000032:analysis; D016559:Tacrolimus / Q000627:therapeutic use*; D014184:Transplantation, Homologous / Q000276:immunology; D014185:Transplantation, Isogeneic / Q000276:immunology
D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D016753:Interleukin-10; D016572:Cyclosporine; D053804:Granzymes; C509215:Gzmb protein, rat; D012697:Serine Endopeptidases; D016559:Tacrolimus