Hypersensitivity reactions to carboplatin in children.
Hypersensitivity reactions to carboplatin are rare but sometimes life-threatening events may occur requiring discontinuation of treatment. In our study, we describe clinical features and diagnostic procedures of carboplatin-associated reactions in children affected by low-grade astrocytoma and treated with multiple courses of carboplatin. In 6 out of 29 children, we reported allergic events. We also report a desensitization protocol for carboplatin administration, which allowed the patients to receive effective treatment without adverse reactions.
Lazzareschi
Ilaria
I
Division of Pediatric Oncology, Catholic University of Rome, Italy.
Ruggiero
Antonio
A
Riccardi
Riccardo
R
Attinà
Giorgio
G
Colosimo
Cesare
C
Lasorella
Anna
A
D018926:Anti-Allergic Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001254:Astrocytoma / Q000175:diagnosis / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D002744:Chlorpheniramine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D016896:Treatment Outcome
D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D002744:Chlorpheniramine; D016190:Carboplatin; D006854:Hydrocortisone; D004837:Epinephrine