title: B cells and immunoglobulins dependent mechanisms in rheumatoid arthritis: a possible rationale of the extracorporeal immunomodulation for rheumatoid arthritis.
abstract: Patients with rheumatoid arthritis (RA) have several options for treatment nowadays, although we do not know what types of therapies are effective for these patients because RA is a very heterogenous disease. We discuss several possible mechanisms of RA in this review and explain one possible scenario of autoantibodies dependent arthritis confirmed by anti-glucose-6-phosphate isomerase antibodies. We also propose several efficacious treatments for treating these patients as made-to-order therapies.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. ismatsu@md.tsukuba.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sumida
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000628:therapy; D001402:B-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D007136:Immunoglobulins / Q000276:immunology*; D051379:Mice
chemical_list: D007136:Immunoglobulins