title: Secretion of inhibin A and inhibin B during pregnancy and early postpartum period in Japanese monkeys.
abstract: In order to determine the profiles and sources of inhibin A and inhibin B during pregnancy in Japanese monkeys, serum samples were collected from eight monkeys for measuring concentrations of both inhibins by enzyme-linked immunosorbent assay. The term placenta was used for the localization of inhibin alpha-, betaA-, and betaB-subunits by immunohistochemistry. Serum concentrations of inhibin A showed a significant rise at the second quarter and maintained its level until term. Serum concentrations of inhibin B gradually increased until the fourth quarter. The concentration of both inhibins abruptly declined after delivery to the nonpregnant level. Positive staining of inhibin alpha-, betaA-, and betaB-subunits was observed in syncytiotrophoblast in the placenta by immunohistochemistry. These results demonstrated that large amounts of both dimeric inhibins are secreted from the placenta of Japanese monkeys.
authors.affiliation: Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Fuchu, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kojima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kondo
authors.forename: WanZhu
authors.initials: W
authors.lastname: Jin
authors.forename: Keiko
authors.initials: K
authors.lastname: Shimizu
authors.forename: Mariko
authors.initials: M
authors.lastname: Itoh
authors.forename: Gen
authors.initials: G
authors.lastname: Watanabe
authors.forename: N P
authors.initials: NP
authors.lastname: Groome
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Taya
mesh_terms: D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008251:Macaca / Q000502:physiology*; D008597:Menstrual Cycle / Q000502:physiology; D010920:Placenta / Q000737:chemistry / Q000378:metabolism; D049590:Postpartum Period; D011247:Pregnancy; D014327:Trophoblasts / Q000737:chemistry
chemical_list: C422362:inhibin A; C422364:inhibin B; D007265:Inhibins