Castleman's disease: an unusual cause of mediastinal mass and anemia.
We reported a case of thoracic localized, mixed variant, Castleman's Disease (angiofollicular lymph node hyperplasia) with a favourable clinical course presenting with mediastinal mass, microcytic anemia, mild thrombocytosis, polyclonal hyper-gammaglobulinaemia and without symptoms. Castleman's Disease must be always considered in the differential diagnosis of solitary mediastinal masses. Transthoracic fine needle aspiration cytology is usually nondiagnostic; in fact, cytologically, Castleman's Disease can be confused with other mediastinal lymphoproliferative disorders (such as thymomas or lymphomas). The optimal therapeutic approach is unknown but a complete surgical resection is treatment of choice for localized disease.
Candoni
A
A
Division of Hematology and Bone Marrow Transplantation, University Hospital, Udine, Italy. Ematologia@drmm.uniud.it
Michelutti
T
T
Morelli
A
A
Geromin
A
A
Damiani
D
D
Scott
C
C
Fanin
R
R
D000328:Adult; D000740:Anemia / Q000209:etiology; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008482:Mediastinum / Q000473:pathology; D011086:Polycythemia / Q000209:etiology; D013902:Radiography, Thoracic; D013997:Time Factors; D014057:Tomography, X-Ray Computed