title: IL-6 and lipoprotein(a) [LP(a)] concentrations are related only in patients with high APO(a) isoforms in monoclonal gammopathy.
abstract: We have investigated the influence of apo(a) genetics on the relationship between interleukin (IL)-6, and lipoprotein (a) [Lp(a)] levels in 154 patients with monoclonal gammopathy and 189 healthy subjects. No significant differences in Lp(a) levels and distribution of subjects with different sizes of apo(a) isoforms were found between patients and healthy controls. Relationship between IL-6 and Lp(a) levels was strongly dependent on the size of apo(a) isoforms. In patients with high-size apo(a) isoforms Lp(a) levels positively correlated (r=0.475, P=0.0007) to IL-6 concentrations, whereas no correlation was found in patients with low apo(a) isoforms. Our present finding may provide a plausible explanation for the contradictory findings about the acute phase protein nature of Lp(a).
authors.affiliation: 3rd Department of Medicine, Faculty of Medicine, Semmelweis University Budapest, Hungary.
authors.forename: Laura
authors.initials: L
authors.lastname: Horváth
authors.forename: Albert
authors.initials: A
authors.lastname: Császár
authors.forename: András
authors.initials: A
authors.lastname: Falus
authors.forename: Hans
authors.initials: H
authors.lastname: Dieplinger
authors.forename: Anna
authors.initials: A
authors.lastname: Horváth
authors.forename: Eva
authors.initials: E
authors.lastname: Puskás
authors.forename: Gabriella
authors.initials: G
authors.lastname: Halm
authors.forename: Anikó
authors.initials: A
authors.lastname: Bányai
authors.forename: Katalin
authors.initials: K
authors.lastname: Pálóczi
authors.forename: Elöd
authors.initials: E
authors.lastname: László
authors.forename: László
authors.initials: L
authors.lastname: Kalabay
authors.forename: László
authors.initials: L
authors.lastname: Romics
authors.forename: George
authors.initials: G
authors.lastname: Füst
mesh_terms: D000328:Adult; D000368:Aged; D001054:Apolipoproteins A / Q000096:biosynthesis* / Q000737:chemistry*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D017270:Lipoprotein(a) / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism; D010265:Paraproteinemias / Q000378:metabolism*; D011110:Polymorphism, Genetic; D020033:Protein Isoforms; D008258:Waldenstrom Macroglobulinemia / Q000378:metabolism
chemical_list: D001054:Apolipoproteins A; D015850:Interleukin-6; D017270:Lipoprotein(a); D020033:Protein Isoforms