title: Theoretical modeling of oral absorption of barbiturates.
abstract: The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.
authors.affiliation: School of Pharmacy, Tabriz Medical Sciences University, Iran. ghafourt@tbzmed.ac.ir
authors.forename: Taravat
authors.initials: T
authors.lastname: Ghafourian
authors.forename: Mohammad
authors.initials: M
authors.lastname: Barzegar-Jalali
mesh_terms: D000042:Absorption; D001463:Barbiturates / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D009061:Mouth Mucosa / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D001463:Barbiturates