Calculation of composite recovery time: a new pharmacodynamic parameter.
A new pharmacodynamic parameter, the composite recovery time (CRT), is described and used to calculate species-specific MIC breakpoints. Moxifloxacin data were used for illustration. This required determination of MICs, kill curves and post-antibiotic sub-MIC effect values. Thirteen test isolates included Staphylococcus aureus, Haemophilus influenzae and Streptococcus pneumoniae. The concentration at which the CRT equals the dosing interval is the minimum effective concentration, and is effectively the breakpoint. The breakpoints were calculated as 2 mg/L for the pneumococci and quinolone-susceptible H. influenzae isolate, 1 mg/L for staphylococci and 0.5 mg/L for Enterobacteriaceae. Calculated pharmacodynamic breakpoints were very similar to traditional published MIC breakpoints.
MacKenzie
Fiona M
FM
Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK. f.m.mackenzie@abdn.ac.uk
Milne
Kathleen E
KE
Gould
Ian M
IM
D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001372:Aza Compounds; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D024841:Fluoroquinolones; D006193:Haemophilus influenzae / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods* / Q000706:statistics & numerical data; D000077266:Moxifloxacin; D011804:Quinolines; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000254:growth & development
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin