title: Outcomes and prognostic factors after surgical resection of hypopharyngeal and cervical esophageal carcinomas.
abstract: Carcinomas of the hypopharynx and the cervical esophagus carry poor prognosis regardless of any treatment modality. To improve long-term survival, prognostic factors for overall survival after surgical resection of these tumors were investigated. Clinical and pathological data from 52 patients undergoing surgical resection for hypopharyngeal (n = 20) and cervical esophageal (n = 32) cancers were reviewed to assess treatment outcomes and prognostic factors. The in-hospital mortality and morbidity rates were 13.5% and 50%, respectively. The 5-year survival rate of the 52 patients was 31.2%. The depth of tumor invasion, quality of tumor clearance, gender of the patients, postoperative complications, and intramural metastasis were revealed by the univariate analysis to be significant prognostic factors. The first four of these factors were specified by the multivariate analysis as independent prognostic factors for overall survival. Complete clearance of loco-regional disease and prevention of postoperative complications are of particular importance for the improvement of long-term survival in patients with these cancers.
authors.affiliation: Department of Regeneration and Transplant Medicine, Graduate School of Medicine and Dental Sciences, Niigata University, Niigata City, Japan. nishimak@med.u-ryukyu.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nishimaki
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kanda
authors.forename: Satoru
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kosugi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tanabe
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Hatakeyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004938:Esophageal Neoplasms / Q000401:mortality / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010611:Pharyngectomy; D011183:Postoperative Complications; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome