Analgesic and antiinflammatory properties of Sideritis lotsyi var. Mascaensis.
The antiinflammatory, analgesic and antimicrobial activities of crude ethanol extracts of Sideritis lotsyi var. mascaensis (Lamiaceae), and chloroform and aqueous fractions were evaluated in mice using paw and ear oedema induced by carrageenan and 12-o-tetradecanoyl-phorbol-acetate (TPA), respectively, as inflammation models, the writhing test induced by acetic acid for evaluating analgesic activity and the disk-diffusion method for testing antimicrobial actions. The results obtained demonstrated significant topical antiinflammatory and analgesic activities for the ethanol extract and chloroform fraction, but no relevant antimicrobial activity against the microorganisms tested.
Hernández-Pérez
Margarita
M
Departamento de Enfermería, EU de Enfermería y Fisioterapia, Universidad de La Laguna, Tenerife, Spain.
Rabanal Gallego
Rosa M
RM
D019342:Acetic Acid / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002351:Carrageenan / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004431:Ear, External; D005260:Female; D006614:Hindlimb / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D031365:Sideritis; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D023382:Toxicity Tests, Acute
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan; D013755:Tetradecanoylphorbol Acetate; D019342:Acetic Acid