Does cardiopulmonary bypass alter plasma level of tumor markers? CA 125 and carcinoembryonic antigen.
BACKGROUND
In addition to malignant diseases, acute and chronic inflammations may elevate plasma levels of tumor markers CA 125 and carcinoembryonic antigen (CEA). Cardiopulmonary bypass (CPB) causes a generalized inflammatory response. In this study, we have investigated the effect of CPB on plasma levels of CA 125 and CEA.


METHODS
We measured plasma levels of CA 125 and CEA in patients undergoing coronary artery bypass grafting (CABG) with CPB (Group 1, n = 21), and in patients who underwent off-pump CABG, that is, without CPB (Group 2, n = 16). Blood samples were collected preoperatively, and on postoperative days 1, 6, and 12.


RESULTS
Within both groups, CEA plasma levels were not significantly influenced in any samples. Comparing with preoperative values, CA 125 values elevated significantly on postoperative days 6 and 12 within both groups. It was observed that the elevation of CA 125 plasma levels in these samples were significantly higher in Group 1.


CONCLUSIONS
The results indicate that CPB elevated plasma level of CA 125. However, clinical importance of this finding needed further evaluation.
Battaloglu
B
B
Inonu University, Turgut Ozal Medical Center, Dept. of Cardiovascular Surgery, Malatya, Turkey. bebat@superonline.com
Kaya
E
E
Erdil
N
N
Nisanoglu
V
V
Kosar
F
F
Ozgur
B
B
Yildirim
B
B
Karagoz
H
H
D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen