title: Plasma amino acid concentrations in 36 dogs with histologically confirmed superficial necrolytic dermatitis.
abstract: Plasma amino acid concentrations were measured in 36 dogs diagnosed with superficial necrolytic dermatitis (SND) via skin biopsy. The median age of the dogs was 10 years, and 27 out of 36 (75%) were male. Twenty-two out of 36 (61%) of the dogs were accounted for by six breeds; West Highland white terriers (six), Shetland sheepdogs (five), cocker spaniels (four), Scottish terriers (three), Lhasa apsos (two) and Border collies (two). The mean concentration (+/- standard deviation) was calculated for each measured plasma amino acid and compared to previously documented concentrations of plasma amino acids measured in dogs with acute and chronic hepatitis. The ratio of branched chain amino acids to aromatic amino acids in the dogs with SND was 2.6, slightly lower than that in normal dogs. The mean plasma amino acid concentrations for dogs with SND were significantly lower than for dogs with acute and chronic hepatitis. A metabolic hepatopathy in which there is increased hepatic catabolism of amino acids is hypothesized to explain the hypoaminoacidaemia seen in SND.
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. caouterbridge@vmth.ucdavis.edu
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Outerbridge
authors.forename: Stanley L
authors.initials: SL
authors.lastname: Marks
authors.forename: Quinton R
authors.initials: QR
authors.lastname: Rogers
mesh_terms: D000596:Amino Acids / Q000097:blood*; D000818:Animals; D001947:Breeding; D016022:Case-Control Studies; D003872:Dermatitis / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D003920:Diabetes Mellitus / Q000097:blood / Q000473:pathology / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood* / Q000401:mortality / Q000473:pathology; D004285:Dogs; D005260:Female; D008107:Liver Diseases / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013577:Syndrome
chemical_list: D000596:Amino Acids