title: Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos.
abstract: Two Lhasa Apsos were diagnosed with lissencephaly based on MR imaging and clinical findings. Histologic confirmation of the diagnosis was obtained in one dog. The MR imaging appearance of the brain in 2 Lhasa Apsos with lissencephaly was of a smooth cerebral surface and a thick neocortex with an absence of the corona radiata. This correlated very well with the histopathologic findings in the dog. Our findings, together with the histopathologic features reported previously, are most consistent with Lhasa Apsos having the canine equivalent of human classical lissencephaly. MR is the imaging modality of choice for antemortem diagnosis of canine lissencephaly.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, USA.
authors.forename: Miyoko
authors.initials: M
authors.lastname: Saito
authors.forename: Nicholas J H
authors.initials: NJ
authors.lastname: Sharp
authors.forename: Gregg D
authors.initials: GD
authors.lastname: Kortz
authors.forename: Alexander
authors.initials: A
authors.lastname: de Lahunta
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Leventer
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Tokuriki
authors.forename: Donald E
authors.initials: DE
authors.lastname: Thrall
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D001947:Breeding; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000662:veterinary