title: Expression of ets-1 and ets-2 in colonic neoplasms.
abstract: BACKGROUND
  Investigation of transcription regulators in carcinoma can contribute greatly to clarifying the biological character of the carcinoma. In this study, we examined the expression of ets-1 and ets-2, prominent transcription regulators belonging to the ets family, in various colonic tissues.
  
  
  METHODS
  We investigated the expression of ets-1 and ets-2 in normal colon, hyperplastic polyps, adenomas, carcinoma-in-adenoma and colonic adenocarcinomas by means of immunohistochemistry.
  
  
  RESULTS
  Expression of ets-1 and ets-2 was not observed in normal colon and hyperplastic polyp. The ets-1 labeling index significantly increased with the successive events of colonic carcinogenesis. A similar tendency was observed for ets-2 expression in colonic neoplasms. In adenocarcinoma, ets-1 and ets-2 expression was directly linked to lymph node metastasis.
  
  
  CONCLUSIONS
  These results suggest that ets-1 and ets-2 may act as transcription regulators of the genes related to colonic carcinogenesis and the progression of colonic adenocarcinoma.
authors.affiliation: Department of Surgery, Osaka Seamen's Insurance Hospital, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeda
authors.forename: Masanao
authors.initials: M
authors.lastname: Okada
authors.forename: Nariaki
authors.initials: N
authors.lastname: Matsuura
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D003106:Colon / Q000378:metabolism / Q000473:pathology; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D003111:Colonic Polyps / Q000378:metabolism / Q000473:pathology; D004268:DNA-Binding Proteins; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D050784:Proto-Oncogene Protein c-ets-1; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D015534:Trans-Activators / Q000096:biosynthesis*; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: D004268:DNA-Binding Proteins; C107465:ERF protein, human; C494041:ETS1 protein, human; C494069:ETS2 protein, human; D050784:Proto-Oncogene Protein c-ets-1; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors