Won't you be my neighbor? Local induction of arteriogenesis.
Two recent papers in Cell and Developmental Cell provide evidence that VEGF directs arterial differentiation. Evidence that sensory nerves direct arteriogenesis and that the membrane-spanning Notch signaling system is downstream of VEGF emphasize the paracrine regulation of vessel formation.
D'Amore
Patricia A
PA
Schepens Eye Research Institute and Harvard Medical School, Boston, MA 02114, USA. pdamore@vision.eri.harvard.edu
Ng
Yin-Shan
YS
D000818:Animals; D001158:Arteries / Q000196:embryology* / Q000294:innervation* / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D004627:Embryonic Induction / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D008222:Lymphokines / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000235:genetics*; D019899:Paracrine Communication / Q000235:genetics; D010525:Peripheral Nerves / Q000196:embryology* / Q000378:metabolism; D051880:Receptors, Notch; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D008565:Membrane Proteins; D051880:Receptors, Notch; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors