title: Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease.
abstract: Neuronal intranuclear rodlets were described in normal brain over a century ago, but their functional significance and pathological relevance is unknown. Here, we show co-localization of tubulin and glucocorticoid receptor-like immunoreactivity in these intranuclear inclusions in human brain. In addition, we provide evidence for a massive reduction in their areal density in Alzheimer's disease brain, but not in another common neurodegenerative condition, dementia with Lewy bodies. The marked reduction of these inclusions in Alzheimer's disease may support the concept of a role for stress hormones in Alzheimer's pathogenesis.
authors.affiliation: Department of Pathology and Laboratory Medicine, The University of Ottawa, The Ottawa Hospital, Ontario, Canada. jwoulfe@ottawahospital.on.ca
authors.forename: John M
authors.initials: JM
authors.lastname: Woulfe
authors.forename: Robert
authors.initials: R
authors.lastname: Hammond
authors.forename: Bryan
authors.initials: B
authors.lastname: Richardson
authors.forename: Danushan
authors.initials: D
authors.lastname: Sooriabalan
authors.forename: William
authors.initials: W
authors.lastname: Parks
authors.forename: Peter
authors.initials: P
authors.lastname: Rippstein
authors.forename: David G
authors.initials: DG
authors.lastname: Munoz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D016022:Case-Control Studies; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000648:ultrastructure*; D020961:Lewy Body Disease / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D019636:Neurodegenerative Diseases / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013347:Subcellular Fractions / Q000648:ultrastructure; D014404:Tubulin / Q000378:metabolism*
chemical_list: D011965:Receptors, Glucocorticoid; D014404:Tubulin