title: Tacrolimus treats ongoing allograft rejection by inhibiting interleukin-10 mediated functional cytotoxic cell infiltration.
authors.affiliation: Fujisawa Research Institute of America, 1801 Maple Avenue, Evanston, IL 60201, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ebbs
authors.forename: F
authors.initials: F
authors.lastname: Pan
authors.forename: C
authors.initials: C
authors.lastname: Wynn
authors.forename: L
authors.initials: L
authors.lastname: Erickson
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000517:prevention & control*; D053804:Granzymes; D016027:Heart Transplantation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016753:Interleukin-10 / Q000037:antagonists & inhibitors*; D008562:Membrane Glycoproteins / Q000032:analysis; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012697:Serine Endopeptidases / Q000032:analysis; D016559:Tacrolimus / Q000627:therapeutic use*; D014184:Transplantation, Homologous / Q000276:immunology; D014185:Transplantation, Isogeneic / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D016753:Interleukin-10; D016572:Cyclosporine; D053804:Granzymes; C509215:Gzmb protein, rat; D012697:Serine Endopeptidases; D016559:Tacrolimus