The effect of beta-carotene on lung and skin carcinogenesis.
The induction of pre-cancerous squamous metaplasia in lungs of ferrets by high doses of dietary beta-carotene (BC) and cigarette smoke is compared with and contrasted to the different effects of high doses of dietary BC on skin papilloma and carcinoma induction by the two-stage carcinogenesis protocol. Whereas high dietary BC can inhibit the conversion of skin papillomas to carcinomas, such treatment would not be expected to inhibit smoke-induced lung tumors.
Wolf
George
G
Department of Nutritional Sciences and Toxicology, University of California, Berkeley CA 94720-3104, USA. retinol@nature.berkeley.edu
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005289:Ferrets; D008175:Lung Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D051379:Mice; D010212:Papilloma / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D012906:Smoke / Q000009:adverse effects*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014026:Nicotiana; D019207:beta Carotene / Q000008:administration & dosage / Q000494:pharmacology*
D002273:Carcinogens; D012906:Smoke; D019207:beta Carotene; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate