The Ran GTPase: theme and variations.
The small GTPase Ran has roles in multiple cellular processes, including nuclear transport, mitotic spindle assembly, the regulation of cell cycle progression and nuclear assembly. The past year has seen a remarkable unification of these different roles with respect to the effectors and mechanisms through which they function. Our emergent understanding of Ran suggests that it plays a central role in spatial and temporal organization of the vertebrate cell.
Dasso
Mary
M
Laboratory of Gene Regulation and Development, NICHD/NIH, Bethesda, MD 20892-5431, USA. mdasso@helix.nih.gov
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D008941:Spindle Apparatus; D020931:ran GTP-Binding Protein / Q000378:metabolism* / Q000502:physiology
D020931:ran GTP-Binding Protein