[Enzymatic resistance of Escherichia coli to beta-lactams and clinical prevalence].
Escherichia coli (E. coli) is the most frequent bacterium implicated in community-acquired infection as well as in nosocomial infections. This bacterium is characterised by numerous possibilities to acquire resistance mechanisms, even during antibiotic treatment. The main mechanism of resistance is the production of beta-lactamines, enzymes hydrolysing beta-lactam ring. This paper describes enzymatic mechanisms of resistance of E. coli to beta-lactam and indicates the necessity of a good knowledge of the risk factors for resistance to have an adapted good clinical practice in using antibiotics.
Lavigne
Jean-Philippe
JP
Laboratoire de bactériologie, CHU Nîmes, France.
Sotto
Albert
A
Merle
Corinne
C
Jourdan
Jacques
J
Soussy
Claude-James
CJ
Sirot
Danielle
D
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases