title: Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.
abstract: We studied here the long-term maintenance of distinct populations of T helper type 1 (T(H)1)-lineage cells in vivo and found that effector T(H)1 cells, defined by their secretion of interferon-gamma (IFN-gamma), are short-lived and do not efficiently develop into long-term memory T(H)1 cells. In contrast, a population of activated T(H)1-lineage cells that did not secrete IFN-gamma after primary antigenic stimulation persisted for several months in vivo and developed the capacity to secrete IFN-gamma upon subsequent stimulation. These data suggest that a linear differentiation pathway, as defined by the transition from IFN-gamma-producing to resting memory cells, is relatively limited in vivo and support a revised model for T(H)1 memory differentiation.
authors.affiliation: Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3005, USA.
authors.forename: Chang-You
authors.initials: CY
authors.lastname: Wu
authors.forename: Joanna R
authors.initials: JR
authors.lastname: Kirman
authors.forename: Masashi J
authors.initials: MJ
authors.lastname: Rotte
authors.forename: Dylan F
authors.initials: DF
authors.lastname: Davey
authors.forename: Steve P
authors.initials: SP
authors.lastname: Perfetto
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Rhee
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Freidag
authors.forename: Brenna J
authors.initials: BJ
authors.lastname: Hill
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Douek
authors.forename: Robert A
authors.initials: RA
authors.lastname: Seder
mesh_terms: D000818:Animals; D016923:Cell Death; D019070:Cell Lineage; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000502:physiology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D018417:Th1 Cells / Q000276:immunology* / Q000502:physiology
chemical_list: D007371:Interferon-gamma