title: Extracellular factors that regulate neuronal migration in the central nervous system.
abstract: Neuronal migration is an essential process in the development of the central nervous system (CNS). The movement of neuronal precursors from their birthplaces to their ultimate position in the adult brain is regulated by extrinsic and intrinsic signals. The understanding of the extracellular factors that regulate neuronal migration has increased significantly in the last few years. In this review, we will discuss the latest insights into the roles of the extracellular matrix (ECM), cell adhesion molecules (CAMs), soluble and membrane-bound factors, neurotransmitters and ion channels in the migration of neurons.
authors.affiliation: Department of Neurology and Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA.
authors.forename: Magdi M
authors.initials: MM
authors.lastname: Sobeih
authors.forename: Gabriel
authors.initials: G
authors.lastname: Corfas
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D009414:Nerve Growth Factors