Successful immune treatment for non-paraneoplastic limbic encephalitis.
A 21-year-old woman subacutely developed memory loss subsequent to gastroenteritis. Brain MRI with gadolinium enhancement showed symmetric involvement of the amygdala. The CSF was acellular with increased protein level. There was no evidence suggestive of neoplasm or viral infection. Combined treatment with plasmapheresis and immunoglobulin improved her clinical symptoms and lessened abnormalities manifested in the MRI. This case suggests the presence of immune-mediated limbic encephalitis without association with neoplasms or infections.
Mori
Masahiro
M
Department of Neurology, Chiba University School of Medicine, 1-8-1, Inohana, Chuo-ku, 260-8670, Chiba, Japan. morim@olive.ocn.ne.jp
Kuwabara
Satoshi
S
Yoshiyama
Mitsuharu
M
Kanesaka
Toshihide
T
Ogata
Tsuyoshi
T
Hattori
Takamichi
T
D000328:Adult; D000679:Amygdala / Q000473:pathology; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D010956:Plasmapheresis