title: [Refractory non-small-cell lung cancer responding to combination chemotherapy with gemcitabine and cisplatin].
abstract: The patient was a 60-year-old female with adenocarcinoma of the lung. An effective radiation therapy was performed for cervical lymph node metastases found 19 months after the operation. A right adrenal metastasis and abdominal paraaortic lymph node metastases were detected 11 months later, and chemotherapy with cisplatin (CDDP) was administered. Although a temporary partial response was obtained, the metastatic lesion was refractory to CDDP. The patient was treated with gemcitabine (GEM) and CDDP, which resulted in near complete response continued for 3 months. The combination therapy of GEM and CDDP may be effective for recurrent non-small-cell lung cancer refractory to other regimens.
authors.affiliation: Dept. of Surgery, Kofu Municipal Hospital.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Akira
authors.initials: A
authors.lastname: Hyougotani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koyama
authors.forename: Tyshiaki
authors.initials: T
authors.lastname: Haba
authors.forename: Kunitaka
authors.initials: K
authors.lastname: Katoh
authors.forename: Akira
authors.initials: A
authors.lastname: Muramatsu
authors.forename: Katsura
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011013:Pneumonectomy; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine