title: 1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives.
abstract: 1,3-Diphenylpyrazole-4-carboxaldehyde and 1-(4-nitrophenyl)-3-phenylpyrazole-4-carboxaldehyde were obtained from the appropriated phenylhydrazones via the Vilsmeier-Haack reaction. These two aldehydes were functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed. In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum.
authors.affiliation: Laboratoire de Chimie Organique, UMR CNRS 6517, Faculté de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Rathelot
authors.forename: Nadine
authors.initials: N
authors.lastname: Azas
authors.forename: Hussein
authors.initials: H
authors.lastname: El-Kashef
authors.forename: Florence
authors.initials: F
authors.lastname: Delmas
authors.forename: Carole
authors.initials: C
authors.lastname: Di Giorgio
authors.forename: Pierre
authors.initials: P
authors.lastname: Timon-David
authors.forename: José
authors.initials: J
authors.lastname: Maldonado
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001391:Azo Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D012995:Solubility; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000977:Antiparasitic Agents; D001391:Azo Compounds; D011720:Pyrazoles