title: Prognostic significance of HIV-associated oral lesions and their relation to therapy.
abstract: The oral manifestations of HIV infection have been considered to be of value in assessing disease progression in the developed world. However, the potential use of oral lesions as prognostic markers in resource-poor countries has yet to be fully investigated. There is reasonably compelling evidence in the developed world for an association between oral lesions and viral load. However, the true nature of this association is less clear and there are few data available from the developing world. With the introduction of HAART, a change in prevalence of the oral manifestations of HIV infection has been observed, including regression of oral candidiasis, Kaposi's sarcoma and oral hairy leukoplakia. However, oral condylomata and herpes simplex virus infection appear to persist with HMRT therapy. Further research in partnership with resource-poor countries is required to document disease progression and the associated oral lesions in both adults and children.
authors.affiliation: Guy's, King's and St Thomas' Dental Institute, London, UK. warren.birnbaum@kel.ac.uk
authors.forename: Warren
authors.initials: W
authors.lastname: Birnbaum
authors.forename: T A
authors.initials: TA
authors.lastname: Hodgson
authors.forename: P A
authors.initials: PA
authors.lastname: Reichart
authors.forename: W
authors.initials: W
authors.lastname: Sherson
authors.forename: W
authors.initials: W
authors.lastname: Nittayananta
authors.forename: S W
authors.initials: SW
authors.lastname: Nittayannanta
authors.forename: T E
authors.initials: TE
authors.lastname: Axell
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000517:prevention & control; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002180:Candidiasis, Oral / Q000517:prevention & control; D002648:Child; D003218:Condylomata Acuminata / Q000150:complications; D019049:Developed Countries; D003906:Developing Countries; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006295:Health Resources; D006801:Humans; D017733:Leukoplakia, Hairy / Q000517:prevention & control; D009059:Mouth Diseases / Q000150:complications* / Q000517:prevention & control; D009062:Mouth Neoplasms / Q000517:prevention & control; D011379:Prognosis; D012514:Sarcoma, Kaposi / Q000517:prevention & control; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents