Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult.
OBJECTIVE
Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemia have been studied.


METHODS
The compounds were tested on ocular blood flow of ocular hypertensive (40 mmHg) rabbit eyes with colored microsphere technique. They were also tested on the retinal function recovery after ischemia of rat eyes with electroretinography.


RESULTS
All compounds (DC-1 through DC-17) showed significant increase in retinal function recovery after ischemia in the range of 26 % to 120 % (P<0.05). Among five compounds (DC-1 through DC-5) studied, four compounds (DC-2 through DC-5) increased the blood flow in choroid, iris, and ciliary body, but not in retina. DC-1 did not show significant increase of blood flow in any of these ocular tissues.


CONCLUSIONS
C-Nitropyrazoles can facilitate significant retinal function recovery after ischemic insult through the increase of ocular blood flow. Since rabbit's retina is scarce in vasculature, it did not show significant change in blood flow by C-nitropyrazoles as expected. Among all 17 compounds, DC-5 seems to be the most potent compound.
Xuan
Bo
B
Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology, Texas A&M University System Health Science Center, College Station, Texas 77843, USA.
Wang
Tao
T
Chiou
George Cy
GC
Dalinger
Igor L'vovich
IL
Shkineva
Tatyana Konstantinovna
TK
Shevelev
Svyatoslav Arkadievich
SA
D000818:Animals; D001393:Azoles / Q000494:pharmacology; D004596:Electroretinography; D005123:Eye / Q000098:blood supply*; D007511:Ischemia / Q000503:physiopathology*; D009574:Nitro Compounds / Q000494:pharmacology; D009798:Ocular Hypertension / Q000503:physiopathology; D018917:Optic Neuropathy, Ischemic / Q000503:physiopathology*; D011720:Pyrazoles / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012160:Retina / Q000502:physiology*; D012161:Retinal Artery / Q000187:drug effects
D001393:Azoles; D009574:Nitro Compounds; D011720:Pyrazoles