Proteomics goes quantitative: measuring protein abundance.
Protein-based methodologies are catching up with established DNA-based methods at an astonishing speed. Recent developments in mass spectrometry enable high-throughput automated identification of proteins as is already the case with DNA sequencing methods. Furthermore, methods for the quantitation of relative protein abundance at the protein level are getting more advanced, which should complement gene expression monitoring at the mRNA level.
Steen
Hanno
H
Department Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Pandey
Akhilesh
A
D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods* / Q000639:trends; D011506:Proteins / Q000032:analysis* / Q000235:genetics*; D040901:Proteomics; D020539:Sequence Analysis, Protein / Q000379:methods* / Q000639:trends
D011506:Proteins