title: Acute renal damage in infants after first urinary tract infection.
abstract: Urinary tract infection (UTI) is one of the most common causes of unexplained fever in neonates. The aim of this study was to determine the incidence of urinary tract anomalies and acute renal damage in neonates who presented with first urinary tract infection in the first 8 weeks of life. We reviewed the records of 95 infants, who were hospitalised with UTI during a 6-year period (1994-1999). Patients with antenatally diagnosed hydronephrosis and incomplete radiological investigations were excluded from the study. Of the remaining 57 patients, 42 were boys and 15 girls. The mean age at diagnosis was 32 days (range 5-60 days). All patients underwent renal ultrasonography (US), voiding cystourethrogram (VCUG) and (99m)Tc-dimercaptosuccinic acid (DMSA) scan. Urinary tract abnormalities were detected in 20 (35%) patients. Vesicoureteral reflux (VUR) was found in 19 (33%) neonates, 7 girls and 12 boys. Acute cortical defects on DMSA scan were present in 19 kidneys of patients with VUR and in 25 of those without reflux. Only one-third of neonates after first symptomatic UTI had VUR. We recommend that US, VCUG, and DMSA scan should be routinely performed after the first UTI in infants younger than 8 weeks.
authors.affiliation: Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cascio
authors.forename: Boris
authors.initials: B
authors.lastname: Chertin
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoneda
authors.forename: Udo
authors.initials: U
authors.lastname: Rolle
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Kelleher
authors.forename: Prem
authors.initials: P
authors.lastname: Puri
mesh_terms: D000208:Acute Disease; D002614:Chelating Agents; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology*; D008297:Male; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D004113:Succimer; D014552:Urinary Tract Infections / Q000000981:diagnostic imaging / Q000473:pathology*; D014718:Vesico-Ureteral Reflux / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology*
chemical_list: D002614:Chelating Agents; D004113:Succimer