title: Antiemetic effects of granisetron, droperidol and dexamethasone in otologic surgery.
abstract: The objective was to assess the antiemetic activity of granisetron, dexamethasone and droperidol in the otologic surgeries. Sixty patients in ASA (American Society of Anesthesiologists) I and II risk groups who underwent surgery for chronic otitis media were assessed in a double blind and randomized trial. The patients were divided into three equal groups. Single intravenous dose of granisetron (3 mg), granisetron (3 mg) plus dexamethasone (8 mg) and droperidol (1.25 mg) were prophylactically administered to the patients in group 1, group 2 and group 3, respectively, and their antiemetic actions were compared. The antiemetic effects of the drugs were not significantly different between the groups (P>0.05). The antiemetic effects also did not differ significantly in the early and late postoperative periods (P>0.05). In conclusion, the results of prophylactic use or side effects of granisetron, granisetron plus dexamethasone or droperidol are similar in middle ear surgery. Therefore, cost effectivity of the antiemetic prophylaxis should be reconsidered in otologic surgery in the light of the results of this study.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey. sitkigoksu@turk.net
authors.forename: Sitki
authors.initials: S
authors.lastname: Goksu
authors.forename: Hasan
authors.initials: H
authors.lastname: Kocoglu
authors.forename: Yildirim A
authors.initials: YA
authors.lastname: Bayazit
authors.forename: Sahin
authors.initials: S
authors.lastname: Yüksek
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Karci
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Kanlikama
authors.forename: Unsal
authors.initials: U
authors.lastname: Oner
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D003907:Dexamethasone / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004329:Droperidol / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D017829:Granisetron / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000601:surgery*; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D003907:Dexamethasone; D004329:Droperidol; D017829:Granisetron