Yersinia type III secretion: send in the effectors.
Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block the cells' response to infection. Understanding the molecular mechanisms of this system has provided insight into the processes of phagocytosis and inflammation.
Cornelis
Guy R
GR
Biozentrum der Universität Basel, Switzerland. guy.cornelis@unibas.ch
D018829:Adhesins, Bacterial / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D012634:Bodily Secretions / Q000382:microbiology*; D022081:Cell Surface Extensions / Q000276:immunology / Q000382:microbiology*; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D010587:Phagocytosis / Q000276:immunology; D021381:Protein Transport / Q000502:physiology*; D015007:Yersinia / Q000378:metabolism* / Q000472:pathogenicity; D015009:Yersinia Infections / Q000378:metabolism* / Q000503:physiopathology
D018829:Adhesins, Bacterial; C064832:YadA protein, Yersinia