Influence of some polysorbates on hydrocortisone release from hydrophilic gels considered as two-compartment models.
Hydrocortisone release from hydrogels containing of 1% and 3% polysorbate 20 or polysorbate 80, in the presence of 1,2-propylene glycol or PEG 200 has two stages. In the first one the release rates are higher than those of the second stage. Half-release times in the first stage are in the range 0.31 h to 0.48 h and in the second stage 16.65 h to 23.22 h. Hydrocortisone release from the gels containing of 1% to 3% of polysorbate 21 or 81, in the presence of 1,2-propylene glycol or PEG 200 conform to second order kinetics. Release rates in this stage are in the range from 3.80 x 10(-4)%.h-1 to 5.97 x 10(-4)%.h-1.
Kubis
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Department of Pharmaceutical Technology, Wroclaw Medical University, Wroclaw, Poland.
Musial
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Szczesniak
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D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D005079:Excipients; D005782:Gels; D006854:Hydrocortisone / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D007700:Kinetics; D008962:Models, Theoretical; D011136:Polysorbates / Q000737:chemistry*; D014783:Viscosity
D000893:Anti-Inflammatory Agents; D005079:Excipients; D005782:Gels; D011136:Polysorbates; D006854:Hydrocortisone