Human papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women.
HIV-infected women from S o Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD(4)(+) cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD(4)/microL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.
Levi
José E
JE
Laboratory of Virology of the Institute of Tropical Medicine, Emelio Ribas Institute Digene do Brasil, Casa da AIDS, University of São Paulo, SP, Brazil. dudilevi@usp.br
Fink
Maria C S
MC
Canto
Cynthia L M
CL
Carretiero
Nadily
N
Matsubara
Regina
R
Linhares
Iara
I
Das Dores
Gérson B
GB
Castelo
Adauto
A
Segurado
Aluísio
A
Uip
David E
DE
Eluf J
José
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000821:virology*; D006801:Humans; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000150:complications / Q000453:epidemiology / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D014626:Vaginal Smears; D019562:Viral Load
D004279:DNA, Viral