Determination of organically bound iodine by reductive mineralization with aluminium powder. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern. Part 16.
PH. EUR. 2002, JAP 1996 and USP 2000 mineralize organically bound iodine in x-ray contrast media by boiling under reflux with zinc powder in alkaline solution. The reductive mineralization can be performed at room temperature without filtration, when aluminium powder is used. Resulting iodide is titrated by argentometry and potentiometric indication according to the pharmacopoeia or after oxidation with 1,3-dibromo-5,5-dimethylhydantoin by iodometry.
Hilp
M
M
Institut für Pharmazeutische Chemie, Philipps-Universität, Marburg, Germany. Hilp@mailer.uni-marburg.de
D000535:Aluminum / Q000737:chemistry*; D006827:Hydantoins / Q000737:chemistry; D007202:Indicators and Reagents; D017613:Iodine Compounds / Q000032:analysis*; D008903:Minerals / Q000032:analysis*; D010084:Oxidation-Reduction; D010602:Pharmacopoeias as Topic; D011199:Potentiometry; D011208:Powders; D012996:Solutions
D006827:Hydantoins; D007202:Indicators and Reagents; D017613:Iodine Compounds; D008903:Minerals; D011208:Powders; D012996:Solutions; D000535:Aluminum; C056578:1,3-dibromo-5,5-dimethylhydantoin