title: Serum cardiac troponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus.
abstract: OBJECTIVE
  To determine whether serum concentrations of cardiac troponin I (cTnI) and cardiac troponin T (cTnT) are increased in dogs with gastric dilatationvolvulus (GDV) and whether concentrations correlate with severity of ECG abnormalities or outcome.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  85 dogs with GDV.
  
  
  METHODS
  Serum cTnl and cTnT concentrations were measured 12 to 24, 48, 72, and 96 hours after surgery. Dogs were grouped on the basis of severity of ECG abnormalities and outcome.
  
  
  RESULTS
  cTnl and cTnT were detected in serum from 74 (87%) and 43 (51%) dogs, respectively. Concentrations were significantly different among groups when dogs were grouped on the basis of severity of ECG abnormalities (none or mild vs moderate vs severe). Dogs that died (n = 16) had significantly higher serum cTnI (24.9 ng/ml) and cTnT (0.18 ng/ml) concentrations than did dogs that survived (2.05 and < 0.01 ng/ml, respectively). Myocardial cell injury was confirmed at necropsy in 4 dogs with high serum cardiac troponin concentrations.
  
  
  CONCLUSIONS
  Results indicate that concentrations of cTnI and cTnT suggestive of myocardial cell injury can commonly be found in serum from dogs with GDV and that serum cardiac troponin concentrations are associated with severity of ECG abnormalities and outcome.
authors.affiliation: Department of Small Animal Medicine, Faculty of Veterinary Medicine, University of Leipzig, Germany.
authors.forename: Karsten E
authors.initials: KE
authors.lastname: Schober
authors.forename: Corinna
authors.initials: C
authors.lastname: Cornand
authors.forename: Babett
authors.initials: B
authors.lastname: Kirbach
authors.forename: Heike
authors.initials: H
authors.lastname: Aupperle
authors.forename: Gerhard
authors.initials: G
authors.lastname: Oechtering
mesh_terms: D000818:Animals; D015415:Biomarkers; D004283:Dog Diseases / Q000097:blood* / Q000601:surgery; D004285:Dogs; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D013271:Gastric Dilatation / Q000097:blood / Q000601:surgery / Q000662:veterinary*; D008297:Male; D009206:Myocardium / Q000473:pathology; D011446:Prospective Studies; D012720:Severity of Illness Index; D013277:Stomach Volvulus / Q000097:blood / Q000601:surgery / Q000662:veterinary*; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T