[Comparative study of bone resorption markers for the diagnosis of bone metastasis in lung cancer].
NTx and I CTP, a metabolite of type I collagen, were compared as to their usefulness as indicators of bone metastasis in lung cancer. The NTx level was significantly higher in lung cancer patients with bone metastasis (107.9 +/- 56.1 nM BCE/mM) than in those without it (p < 0.0001), as was the I CTP level (10.0 +/- 6.5 ng/ml; p < 0.0001). The Z scores of NTx and I CTP were 2.37 and 2.04, respectively, indicating that NTx is superior to I CTP in sensitivity to bone metastasis because of its higher Z score and its higher area under the ROC curve. The cutoff values of these markers were set to produce the highest accuracy/sensitivity rates and to make possible the highest diagnostic efficiency, and then the odds ratios at these cutoff values were calculated. The odds ratios of NTx and I CTP at cutoff values for the highest accuracy were 66.3 and 12.6, respectively; those offering the highest diagnostic efficiency were 46.5 and 10.0, respectively. These results indicated that NTx offers better prediction of bone metastasis in lung cancer than does I CTP.
Nakamura
Hiroyuki
H
Fifth Department of Internal Medicine, Tokyo Medical University.
Oishi
Syuji
S
Yagyu
Hisanaga
H
Morisako
Takahiro
T
Kishi
Koji
K
Tsuchida
Fumihiro
F
Adachi
Hideki
H
Sarashina
Gen
G
Sudoh
Akihiko
A
Hashimoto
Toshio
T
Matsuoka
Takeshi
T
D014408:Biomarkers, Tumor / Q000378:metabolism; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D001862:Bone Resorption; D003094:Collagen / Q000652:urine*; D024042:Collagen Type I; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000652:urine*; D011347:Procollagen / Q000097:blood; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen