title: Weight and blood pressure change during clozapine treatment.
abstract: We examined whether clozapine-related weight gain is associated with an increase in mean arterial blood pressure. Weight gain and mean arterial blood pressure changes were assessed in 61 outpatients with schizophrenia who were randomly assigned to either clozapine or haloperidol in a 10-week parallel group, double-blind study and in 55 patients who chose to continue to receive clozapine in a subsequent 1-year open-label prospective study. Clozapine treatment was associated with significant weight gain in the double blind and open-label trials. Haloperidol treatment was not associated with significant weight gain. Neither clozapine nor haloperidol treatment were associated with significant changes in mean arterial blood pressure. There were no significant correlations between weight gain and mean arterial blood pressure change with either medication. Although clozapine treatment is associated with weight gain, the correlation between this weight gain and increases in arterial blood pressure during the first year of treatment appears to be low.
authors.affiliation: Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA.
authors.forename: Scott P
authors.initials: SP
authors.lastname: Baymiller
authors.forename: Patricia
authors.initials: P
authors.lastname: Ball
authors.forename: Robert P
authors.initials: RP
authors.lastname: McMahon
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology; D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use; D016001:Confidence Intervals; D004311:Double-Blind Method; D005260:Female; D006220:Haloperidol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine; D006220:Haloperidol