Wnt6 marks sites of epithelial transformations in the chick embryo.
In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm, we have isolated a novel chick Wnt gene, chick Wnt6. This gene encodes the first pan-epidermal Wnt signalling molecule. Further sites of expression are the boundary of the early neural plate and surface ectoderm, the roof of mesencephalon, pretectum and dorsal thalamus, the differentiating heart, and the otic vesicle. The precise sites of Wnt6 expression coincide with crucial changes in tissue architecture, namely epithelial remodelling and epithelial-mesenchymal transformation (EMT). Moreover, the expression of Wnt6 is closely associated with areas of Bmp signalling.
Schubert
Frank R
FR
MRC Centre for Developmental Neurobiology, King's College London, 4th Floor New Hunt's House, Guy's Campus, London SE1 1UL, UK.
Mootoosamy
Roy C
RC
Walters
Esther H
EH
Graham
Anthony
A
Tumiotto
Loretta
L
Münsterberg
Andrea E
AE
Lumsden
Andrew
A
Dietrich
Susanne
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002490:Central Nervous System / Q000196:embryology; D002642:Chick Embryo; D003001:Cloning, Molecular; D007758:Ear, Inner / Q000196:embryology; D004475:Ectoderm / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D015870:Gene Expression; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D010802:Phylogeny; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D011518:Proto-Oncogene Proteins; D012313:RNA