title: [Vaccination of weaner pigs against classical swine fever with the subunit vaccine "Porcilis Pesti": influence of different immunization plans on excretion and transmission of challenge virus].
abstract: Excretion and transmission of CSFV after vaccination with the CSF subunit marker vaccine "Porcilis Pesti" have been studied using the following different vaccination schedules: Group A--two vaccinations with an interval of 28 d, challenge 14 d after second vaccination (p.v2.); group B--two vaccinations with an interval of 14 d, challenge 14 d later; group C--two vaccinations with an interval of 28 d, challenge at time of booster vaccination; group D--two vaccinations with an interval of 14 d, challenge 7 d p.v2.; group E--single vaccination and infection 14 d later. After infection one sentinel pig was added to the vaccinated and infected pigs of each group. A single vaccination did not induce protective immunity against a CSFV challenge. Double vaccination at a four-week interval protected piglets from clinical infection, and neither viraemia and leukopenia nor virus excretion were detected if infected 14 d p.v2. Two vaccinations at a two-week interval followed by a challenge 7 d p.v2. led to a short viraemia on day 5 p.i. but without excretion of CSFV. Though all other vaccination schedules induced a reduction in virus shedding and a decrease in CSFV replication, in all these cases in-contact controls became infected. The results of transmission of CSFV are discussed in relation to a potential use of subunit marker vaccines in CSF control.
authors.affiliation: Bundesforschungsanstalt für Viruskrankheiten der Tiere, Institut für Infektionsmedizin der Friedrich-Loeffler-Institute Insel Riems.
authors.forename: Ute
authors.initials: U
authors.lastname: Ziegler
authors.forename: Volker
authors.initials: V
authors.lastname: Kaden
mesh_terms: D000818:Animals; D006691:Classical Swine Fever / Q000517:prevention & control* / Q000635:transmission*; D006692:Classical Swine Fever Virus / Q000276:immunology*; D007115:Immunization Schedule; D013552:Swine; D014611:Vaccination / Q000662:veterinary*; D022581:Vaccines, Marker / Q000008:administration & dosage; D022223:Vaccines, Subunit / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*; D017201:Virus Shedding
chemical_list: D022581:Vaccines, Marker; D022223:Vaccines, Subunit; D014765:Viral Vaccines