Cancer-homing toxins.
Cancer-homing toxins are a group of man-made cytotoxic molecules targeting cancer cells. In the past decade they have demonstrated potential as cancer therapeutics. These molecules contain a toxin, natural or usually derivatized, connected to a cancer-homing module, such as a monoclonal antibody or growth factor or their derivatives. Various cancer-homing toxins have been designed and tested in cell-lines, animal-models and clinical trials. We review some of these data and discuss ways to better design cancer-homing toxins in the light of advances in cancer genomics, antibody-engineering techniques and computational algorithms.
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Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260. bchkhe@nus.edu.sg
Khoo
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D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D018941:Antigens, CD19 / Q000276:immunology / Q000378:metabolism; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000737:chemistry / Q000627:therapeutic use; D015815:Cell Adhesion Molecules; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000276:immunology / Q000628:therapy; D018432:Drug Resistance, Multiple; D066246:ErbB Receptors / Q000276:immunology / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology* / Q000627:therapeutic use; D037102:Lectins / Q000276:immunology / Q000378:metabolism; D007983:Lewis Blood Group Antigens / Q000276:immunology / Q000378:metabolism; D010940:Plant Proteins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017978:Receptors, Growth Factor / Q000276:immunology / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000378:metabolism; D051918:Sialic Acid Binding Ig-like Lectin 2
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte; D000970:Antineoplastic Agents; D001427:Bacterial Toxins; C497867:CD22 protein, human; D015815:Cell Adhesion Molecules; D000922:Immunotoxins; D037102:Lectins; D007983:Lewis Blood Group Antigens; C094162:Lewis Y antigen; D010940:Plant Proteins; D017978:Receptors, Growth Factor; D015375:Receptors, Interleukin-2; D051918:Sialic Acid Binding Ig-like Lectin 2; D066246:ErbB Receptors