[The influence of nitric synthase inhibitor (L-NAME) on the intraocular pressure in endotoxin induced uveitis in rats].
We studied the influence of the nitric synthase inhibitor (L-NAME) on the induction of uveitis in Wistar rats. The inflammation was induced by a footpad injection of endotoxin in rat. The clinical signs were evaluated in a slit-lamp, the intraocular pressure was measured using Tono Pen tonometer. We showed, that in endotoxin-induced uveitis the intraocular pressure elevation was observed and that L-NAME application reduced the inflammation and the level of the intraocular pressure.
Szymaniec
Stanisław
S
Zakładu Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej Polskiej Akademii Nauk, Wrocławiu.
Misiuk-Hojło
Marta
M
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy*
D004731:Endotoxins; D004791:Enzyme Inhibitors; D019331:NG-Nitroarginine Methyl Ester