title: Metachronous bilateral mammary metaplastic and infiltrating duct carcinomas: a molecular study for clonality.
abstract: Mammary metaplastic carcinoma is uncommon. In this study, both carcinoma and sarcoma components of a metaplastic carcinoma and a subsequent metachronous contralateral infiltrating ductal carcinoma were analyzed by microsatellite analysis for the loss of heterozygosity (LOH) patterns at multiple sites on chromosome arms 3p, 6q, 8, 9p, 11, 13q, 14q, 16q, and 17p. The LOH patterns between the carcinoma and sarcoma components in the first tumor were similar, indicating clonality. The LOH patterns between the first and second tumors were different at all chromosome arms, indicating different clonality and a second primary. We demonstrated a second primary carcinoma in a patient with previous metaplastic carcinoma rather than a metastasis with carcinoma component only.
authors.affiliation: Department of Anatomical and Cellular Pathology, Prince of Wales Hospital and P.H. Chan Medical Laboratories Limited, Hong Kong SAR.
authors.forename: Fred Y L
authors.initials: FY
authors.lastname: Kung
authors.forename: Gary M K
authors.initials: GM
authors.lastname: Tse
authors.forename: Kwok-Wai
authors.initials: KW
authors.lastname: Lo
authors.forename: Bonita K B
authors.initials: BK
authors.lastname: Law
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Chang
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Chen
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000473:pathology*; D002875:Chromosomes; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012509:Sarcoma / Q000473:pathology