title: Genetic analysis of rabies virus isolates in the Philippines.
abstract: To determine the genetic characteristics of the rabies virus in the Philippines, 59 rabies virus isolates were obtained from domestic rabid dogs and their partial nucleotide sequences of nucleoprotein (N) gene were compared. Based on comparison with reported sequences, phylogenetic analysis revealed that all isolates from the Philippines had close genetic relations and formed two subgroups. The Philippines isolates belonged to a different lineage from other Asian isolates but were closer to them than to terrestrial isolates and laboratory strains. Several specific nucleotide and amino acid substitutions were observed among the Philippines isolates. Our results suggest that rabies viruses in the Philippines might have a characteristic evolution.
authors.affiliation: Department of Microbiology, Oita Medical University, Japan. a24zono@oita-med.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Nishizono
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mannen
authors.forename: Luningning P
authors.initials: LP
authors.lastname: Elio-Villa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kang-sheng
authors.initials: KS
authors.lastname: Li
authors.forename: Kumato
authors.initials: K
authors.lastname: Mifune
authors.forename: Benito F
authors.initials: BF
authors.lastname: Arca
authors.forename: Arturo
authors.initials: A
authors.lastname: Cabanban
authors.forename: Benjamin
authors.initials: B
authors.lastname: Martinez
authors.forename: Arlito
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Victor C
authors.initials: VC
authors.lastname: Atienza
authors.forename: Rolando
authors.initials: R
authors.lastname: Camba
authors.forename: Nilo
authors.initials: N
authors.lastname: Resontoc
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004283:Dog Diseases / Q000453:epidemiology / Q000821:virology*; D004285:Dogs; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins / Q000737:chemistry / Q000235:genetics; D010679:Philippines / Q000453:epidemiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000235:genetics* / Q000302:isolation & purification; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D019590:Nucleocapsid Proteins; D012367:RNA, Viral