title: Desmoplastic astrocytoma of infancy: a case report with histopathologic and immunohistochemistry profile.
abstract: The clinicopathological features and immunohistochemistry profile of desmoplastic cerebral astrocytoma of infancy are discussed in a 4 month old male infant who presented with an increasing head circumference more pronounced in the last two weeks prior to admission to the University Pediatric Hospital. This is a rare tumor that occurs in infants within the first two years of life and it is characterized by a massive, often cystic, supratentorial lesion usually in the frontoparietal region. It has a biphasic histologic pattern with an astrocytic and desmoplastic component and a good prognosis after total or near total surgical resection. This patient represents the first case of desmoplastic cerebral astrocytoma of infancy diagnosed in the Puerto Rico Medical Center.
authors.affiliation: Department of Pathology and Laboratory Medicine, Medical Sciences Campus, University of Puerto Rico, PO Box 365067, San Juan, Puerto Rico 00936-5067.
authors.forename: Edda L
authors.initials: EL
authors.lastname: Rodriguez-Morales
authors.forename: Maria S
authors.initials: MS
authors.lastname: Correa Rivas
authors.forename: Castillo E
authors.initials: CE
authors.lastname: Colon
mesh_terms: D001254:Astrocytoma / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D003399:Craniotomy; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011379:Prognosis; D011506:Proteins / Q000032:analysis; D011647:Puerto Rico / Q000453:epidemiology; D016708:Synaptophysin / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D011506:Proteins; D016708:Synaptophysin; D014746:Vimentin; C055324:phospholipase A2-activating protein; D010751:Phosphopyruvate Hydratase