Theileria annulata: virulence and transmission from single and mixed clone infections in cattle.
Theoretically, parasite virulence should be higher for faster growing parasites, and higher in mixed infections compared to single-clone infections. Virulence should also be positively correlated to transmission rates. Theileria annulata provides a good model system for studying such hypotheses, as parasite replication causes harm to the host, and there is evidence suggesting that the genetic complexity of an infection might affect its virulence. Two clones of T. annulata were chosen, one fast growing and one slow growing in vitro and these were used to establish cattle infections, either alone, or in a mixed infection. Virulence was measured using lymph node expansion, temperature, and blood parameters as correlates. As predicted, the faster growing clone was found to produce higher virulence. Mixed infections did not show higher virulence than single-clone infections, but interactions within mixed infections resulted in more transmission stage production than seen in either of the single-clone infections. Index Descriptors and Abbreviations. Theileria annulata, Apicomplexa, mixed infections, virulence, growth rates, red blood cell, RBC; packed cell volume, PCV.
Taylor
Louise H
LH
Centre for Tropical Veterinary Medicine, University of Edinburgh, Roslin, Midlothian, EH25 9RG Scotland, UK. louise_h_taylor@yahoo.co.uk
Welburn
Sue C
SC
Woolhouse
Mark E J
ME
D000818:Animals; D002417:Cattle; D004906:Erythrocyte Count; D005838:Genotype; D006790:Host-Parasite Interactions; D007958:Leukocyte Count; D008297:Male; D018512:Parasitemia / Q000469:parasitology; D016796:Theileria annulata / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D013801:Theileriasis / Q000469:parasitology* / Q000635:transmission*; D014774:Virulence