title: Diffusion MRI for prediction of response of rectal cancer to chemoradiation.
abstract: Prediction of tumour response before onset of treatment could have considerable clinical benefit. Since the apparent diffusion coefficient (ADC) of a tumour's water content can show the extent of necrosis, we looked for a possible correlation of ADC with response to treatment. We measured mean tumour water ADC before and after chemotherapy and chemoradiation in 14 patients with locally advanced rectal cancer, with a quantitative magnetic resonance diffusion imaging sequence. We found a strong negative correlation between mean pretreatment tumour water ADC and percentage size change of tumours after chemotherapy (r=-0.67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour.
authors.affiliation: UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK. andrzej@icr.ac.uk
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dzik-Jurasz
authors.forename: Claudia
authors.initials: C
authors.lastname: Domenig
authors.forename: Mark
authors.initials: M
authors.lastname: George
authors.forename: Jan
authors.initials: J
authors.lastname: Wolber
authors.forename: Anwar
authors.initials: A
authors.lastname: Padhani
authors.forename: Gina
authors.initials: G
authors.lastname: Brown
authors.forename: Simon
authors.initials: S
authors.lastname: Doran
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001834:Body Water / Q000187:drug effects; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents