Effect of nitrous oxide on myogenic motor evoked potentials during hypothermia in rabbits anaesthetized with ketamine/fentanyl/propofol.
BACKGROUND
A number of authors have reported that anaesthetics suppress myogenic motor evoked potentials (MEPs). However, the influence of hypothermia on these effects is unknown. Therefore we investigated the effects of hypothermia on nitrous oxide-induced suppression of myogenic MEPs.


METHODS
Twenty-two rabbits anaesthetized with ketamine, fentanyl and propofol were randomly allocated to one of three groups, with oesophageal temperatures of 40 degrees C (n = 8), 35 degrees C (n = 7) and 30 degrees C (n = 7). Myogenic MEPs in response to electrical stimulation of the motor cortex with a train of five pulses were recorded from the soleus muscle. Following the control recording, nitrous oxide was administered at concentrations of 30%, 50%, and 70% in random order, and MEPs were recorded. Control MEP amplitudes and percentage of control MEP amplitudes (%MEP amplitude) during the administration of nitrous oxide were compared between the three groups.


RESULTS
Control MEP amplitudes were similar between the three groups. Nitrous oxide suppressed MEPs in a dose-dependent manner in all groups. During the administration of nitrous oxide, % MEP amplitudes at 35 degrees C and 30 degrees C (hypothermia) were significantly lower than those at 40 degrees C (normothermia).


CONCLUSIONS
These results suggest that nitrous oxide-induced suppression of MEPs may be augmented during hypothermia.
Kakimoto
M
M
Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Kawaguchi
M
M
Sakamoto
T
T
Inoue
S
S
Takahashi
M
M
Furuya
H
H
D019162:Anesthetics, Combined / Q000494:pharmacology; D000778:Anesthetics, Dissociative / Q000494:pharmacology; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature; D004305:Dose-Response Relationship, Drug; D019054:Evoked Potentials, Motor / Q000187:drug effects*; D005283:Fentanyl / Q000494:pharmacology; D007036:Hypothermia, Induced; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods*; D009609:Nitrous Oxide / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology; D011817:Rabbits
D019162:Anesthetics, Combined; D000778:Anesthetics, Dissociative; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007649:Ketamine; D009609:Nitrous Oxide; D005283:Fentanyl; D015742:Propofol