Cytogenetic abnormalities in a hemangiopericytoma of the spleen.
To date, only 16 cytogenetically abnormal hemangiopericytomas (HP) have been reported. Despite this low number, some characteristic karyotypic features have already emerged: most HP are near-diploid and breakpoints in 12q13, 12q24, and 19q13 seem to be common, with t(12;19)(q13;q13) being a recurrent translocation. Here, we report the first case of a probably benign splenic HP with chromosomal abnormalities. The abnormal karyotype was 47,XX,t(5;22;11)(q31;q11;q13),+10. None of these abnormalities have previously been reported in HP, suggesting that the karyotypic pattern of splenic HP may differ from soft tissue HP.
Hallén
Magnus
M
Department of Surgery, University Hospital, SE-221 85, Lund, Sweden. magnus.hallen@skane.se
Parada
Luis A
LA
Gorunova
Ludmila
L
Pålsson
Birger
B
Dictor
Michael
M
Johansson
Bertil
B
D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006393:Hemangiopericytoma / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008297:Male; D013160:Splenic Neoplasms / Q000235:genetics*