title: [123I]-phenylpentadecanoic acid uptake in patients with dilated cardiomyopathy.
abstract: BACKGROUND
  The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM).
  
  
  METHODS
  10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions.
  
  
  RESULTS
  All patients showed non-homogeneous tracer uptake defects for 201TI and IPPA. k(1) was significantly higher in DCM patients than controls. k(1) showed significant inverse correlation between cardiac index, left-ventricular ejection fraction, left-ventricular enddiastolic pressure and echocardiographic left-ventricular ejection fraction.
  
  
  CONCLUSIONS
  We presume that an increased regional rate constant of IPPA influx into the myocardial tissue in patients with DCM reflects a compensatory mechanism of altered myocardium.
authors.affiliation: Herz-Kreislauf-Zentrum Gernsbach/Schwarzwald, Germany. cardiol@hkz-gernsbach.de
authors.forename: Eckart
authors.initials: E
authors.lastname: Miche
authors.forename: Andrea
authors.initials: A
authors.lastname: Radzewitz
authors.forename: Gunawan
authors.initials: G
authors.lastname: Notohamiprodjo
authors.forename: Detlev
authors.initials: D
authors.lastname: Baller
authors.forename: Axel
authors.initials: A
authors.lastname: Kloppe
authors.forename: Siegfried
authors.initials: S
authors.lastname: Eckert
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gleichmann
mesh_terms: D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000000981:diagnostic imaging / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; C025391:omega-(4-iodophenyl)pentadecanoic acid