The possible relationship between onco/suppressor gene expression and carcinogen exposure in vivo: evaluation of a potential biomarker in preventive and predictive medicine.
An understanding of the molecular changes occuring during exposure to a carcinogen enhances the possibility of cancer prevention. Molecular genetic-biological screening methods offer the potential for early diagnosis of high-risk groups, and identification of specific signals, as a major step in primary prevention. Recent investigations have suggested that oncogene or oncosuppressor gene expression investigation at the RNA level is a proper and early molecular epidemiological biomarker of carcinogen exposure and a tool for risk assessment. This is one way by which the high-risk groups could be recognized. At the protein level, the investigation of gene expression is very useful in molecular diagnosis and in molecular pathology.
Ember
István
I
Department of Public Health, Faculty of Medicine, University of Sciences, Pécs, Hungary. ember@pubhealth.pote.hu
Gyöngyi
Zoltán
Z
Kiss
István
I
Ghodratollah
Nowrasteh
N
Arany
István
I
D014408:Biomarkers, Tumor / Q000032:analysis; D002273:Carcinogens / Q000633:toxicity*; D004781:Environmental Exposure; D016147:Genes, Tumor Suppressor / Q000187:drug effects; D006801:Humans; D009857:Oncogenes / Q000187:drug effects; D011237:Predictive Value of Tests; D012307:Risk Factors
D014408:Biomarkers, Tumor; D002273:Carcinogens