title: Increased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase.
abstract: In the present study, we flow cytometrically analyzed the intracellular production of interleukin (IL)-5 and IL-13 in peripheral blood CD4(+) and CD8(+) T cells from patients with multiple sclerosis (MS), human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and healthy controls. IL-13-producing T cells were significantly increased in both T cell subsets in MS at relapse, markedly in the conventional form of MS and modestly in the optocospinal form of MS, and returned to normal at remission. However, IL-5-producing T cells did not vary regardless of clinical phase or type. HAM/TSP showed no significant change in the number of IL-5- and IL-13-producing cells. A distinct profile of IL-13 and IL-5 production by disease and by phase of MS suggests an active involvement of these type 2 cytokines in central nervous system (CNS) inflammation.
authors.affiliation: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ochi
authors.forename: Manabu
authors.initials: M
authors.lastname: Osoegawa
authors.forename: Xiao-Mu
authors.initials: XM
authors.lastname: Wu
authors.forename: Motozumi
authors.initials: M
authors.lastname: Minohara
authors.forename: Izumi
authors.initials: I
authors.lastname: Horiuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Murai
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Furuya
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kira
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D018793:Interleukin-13 / Q000378:metabolism*; D015848:Interleukin-5 / Q000378:metabolism*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology*; D015493:Paraparesis, Tropical Spastic / Q000276:immunology; D012008:Recurrence
chemical_list: D018793:Interleukin-13; D015848:Interleukin-5