title: Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever.
abstract: In Iquitos, Peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by American genotype dengue-2 (American dengue-2) virus. We assayed serum samples collected in Iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two American dengue-2 viruses, and two Asian dengue-2 viruses. Sera positive for the dengue-1 antibody neutralised dengue-1 viruses and American dengue-2 viruses much more effectively than Asian dengue-2 viruses. Neutralisation of American dengue-2 virus by sera positive for dengue-1 antibodies may account for the absence of dengue haemorrhagic fever in individuals infected with dengue-1 in 1990-91 followed by American dengue-2 virus in 1995 in Iquitos, Peru.
authors.affiliation: Department of Virology, Naval Medical Research Centre Detachment, Lima, Peru. Kochel@namrid.sld.pe
authors.forename: Tadeusz J
authors.initials: TJ
authors.lastname: Kochel
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Watts
authors.forename: Scott B
authors.initials: SB
authors.lastname: Halstead
authors.forename: Curtis G
authors.initials: CG
authors.lastname: Hayes
authors.forename: Angelica
authors.initials: A
authors.lastname: Espinoza
authors.forename: Vidal
authors.initials: V
authors.lastname: Felices
authors.forename: Roxana
authors.initials: R
authors.lastname: Caceda
authors.forename: Christian T
authors.initials: CT
authors.lastname: Bautista
authors.forename: Ysabel
authors.initials: Y
authors.lastname: Montoya
authors.forename: Susan
authors.initials: S
authors.lastname: Douglas
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Russell
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D003715:Dengue / Q000276:immunology; D003716:Dengue Virus / Q000145:classification* / Q000276:immunology; D006801:Humans; D010568:Peru; D016133:Polymerase Chain Reaction; D012703:Serotyping; D019595:Severe Dengue / Q000276:immunology
chemical_list: D000914:Antibodies, Viral