Cholinergic modulation of experience-dependent plasticity in human auditory cortex.
The factors that influence experience-dependent plasticity in the human brain are unknown. We used event-related functional magnetic resonance imaging (fMRI) and a pharmacological manipulation to measure cholinergic modulation of experience-dependent plasticity in human auditory cortex. In a differential aversive conditioning paradigm, subjects were presented with high (1600 Hz) and low tones (400 Hz), one of which was conditioned by pairing with an electrical shock. Prior to presentation, subjects were given either a placebo or an anticholinergic drug (0.4 mg iv scopolamine). Experience-dependent plasticity, expressed as a conditioning-specific enhanced BOLD response, was evident in auditory cortex in the placebo group, but not with scopolamine. This study provides in vivo evidence that experience-dependent plasticity, evident in hemodynamic changes in human auditory cortex, is modulated by acetylcholine.
Thiel
Christiane M
CM
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1 3BG, United Kingdom. c.thiel@fz-juelich.de
Friston
Karl J
KJ
Dolan
Raymond J
RJ
D000109:Acetylcholine / Q000378:metabolism*; D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001303:Auditory Cortex / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D001307:Auditory Perception / Q000187:drug effects / Q000502:physiology*; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D020532:Basal Nucleus of Meynert / Q000187:drug effects / Q000502:physiology*; D001931:Brain Mapping; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D018727:Muscarinic Antagonists; D012601:Scopolamine; D000109:Acetylcholine