Plasma agouti-related protein level: a possible correlation with fasted and fed states in humans and rats.
We measured plasma concentrations of agouti-related protein (AGRP) in humans and rats and determined whether these were affected by ingestion of a meal after fasting. In 17 healthy human subjects, the mean plasma concentration of AGRP was lower in the fed state than in the fasted state. Two hours after a breakfast meal, AGRP levels dropped by 39%. By contrast, a continued fast for 2 h increased the average AGRP concentration by 73%. In rats with diet-induced obesity, refeeding resulted in a 50% decrease in plasma AGRP concentrations following a fasting-refeeding protocol. Our results support the notion that plasma AGRP may serve as a biomarker for the transition from a fasted to the satiated state.
Shen
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CP
Department of Obesity and Metabolic Research, Merck Research Laboratories, Rahway, NJ 07065, USA. chunpyn_shen@merck.com
Wu
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KK
Shearman
L P
LP
Camacho
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Tota
M R
MR
Fong
T M
TM
Van der Ploeg
L H T
LH
D000328:Adult; D054369:Agouti-Related Protein; D000704:Analysis of Variance; D000818:Animals; D004435:Eating / Q000502:physiology; D005215:Fasting / Q000097:blood; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D011506:Proteins / Q000032:analysis*; D051381:Rats; D013997:Time Factors
C515198:AGRP protein, human; C515197:AGRP protein, rat; D054369:Agouti-Related Protein; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins