[The distributive features of three kinds of metabolic genes polymorphisms in population of Han nationality in south area of China].
OBJECTIVE
To find out the distributive features of some metabolic genes polymorphisms in Han population of south area of China.


METHODS
Study population was obtained from the controls of a community based case-control study, which included 290 blood relatives (inner control) and 404 non-blood relatives (outer control).


RESULTS
Frequencies of CYP1A1, GSTM1 and GSTT1 polymorphisms had no significant difference among confounding factors, such as sex, living areas, stomach cancer family history and history of tobacco smoking etc. Some controls showed significant difference in age group and alcohol drinking which would be adjusted in analysis of the relationship between polymorphisms and cancers. CYP1A1 Ile/Val and Val/Val genotypes were 33.43% and 5.62% respectively, which were similar to other results from Chinese and Japanese, but higher than those from Caucasians in American, Europe and African-Americans. GSTM1 null allele frequency was 53.48% in our population, which showed difference even among Chinese in different areas. GSTT1 null allele frequency was 45.78%, which was significantly higher than that in Caucasians and African-American.


CONCLUSIONS
The frequencies of CYP1A1 Ile/Val, Val/Val and GSTT1 null in Han population in south area of China are significantly higher than those in other races, while the ethnic difference of frequency of GSTM1 null is less.
Shen
Jing
J
School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, 210029 P.R.China. jingshen@263.net
Wang
Runtian
R
Wang
Zhaoxi
Z
Xing
Houxun
H
Wang
Liwei
L
Wang
Bingyan
B
Li
Maosen
M
Hua
Zhaolai
Z
Wang
Jianming
J
Guo
Chunhua
C
Wang
Xinru
X
Xu
Xiping
X
D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005843:Geography; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D019363:Cytochrome P-450 CYP1A1; D004247:DNA; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1