Intracranial perineural extension of invasive mycosis: a novel mechanism of disease propagation by Aspergillus fumigatus.
We describe an immunocompetent woman who had refractory, invasive sphenoid sinus Aspergillus fumigatus infection for which there was radiologic evidence of intracranial perineural spread. The patient responded to a combination of antifungal and adjuvant recombinant cytokine therapy.
Safdar
Amar
A
Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, PalmettoRichland Memorial Hospital, Columbia, SC 29203, USA. safdar@richmed.medpark.sc.edu
Dommers
Martin P
MP
Talwani
Rohit
R
Thompson
Charlotte R
CR
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D001232:Aspergillus fumigatus; D016207:Cytokines / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007121:Immunocompetence; D010502:Perineum / Q000382:microbiology*; D011859:Radiography
D000935:Antifungal Agents; D016207:Cytokines