Extravascular necrotizing palisaded granulomas as the presenting skin sign of systemic lupus erythematosus.
We recently examined a patient who presented clinically with tender, erythematous papules associated with a febrile illness and polyarthralgias. Histopathological examination revealed extravascular palisaded neutrophilic granulomas, a skin reaction pattern originally described in Churg-Strauss disease but subsequently observed in a variety of other systemic disorders characterized by immune complex generation. A diagnosis of systemic lupus erythematosus (SLE) was established. To our knowledge, this is the first report of extravascular necrotizing palisaded granulomas as the presenting skin sign of SLE.
Obermoser
G
G
Department of Dermatology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. gerlinde.obermoser@uibk.ac.at
Zelger
B
B
Zangerle
R
R
Sepp
N
N
D000328:Adult; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
D003176:Complement C3