Effects of efonidipine on platelet and monocyte activation markers in hypertensive patients with and without type 2 diabetes mellitus.
We compared the levels of microparticles, platelet activation markers, soluble cell adhesion molecules, and soluble selectins between hypertensive patients with and without type 2 diabetes and control subjects. Binding of anti-glycoprotein IIb/IIIa and anti-glycoprotein Ib monoclonal antibodies to platelets did not differ significantly between the hypertensive patients and controls, but platelet expression of activation markers (CD62P, CD63, PAC-1, and annexin V) was higher in the hypertensive patients. Platelet-derived microparticle (PDMP) and monocyte-derived microparticle (MDMP) levels were significantly higher in the hypertensive patients than in the controls. Soluble ICAM-1, VCAM-1, P-selectin, and E-selectin levels were also higher in the hypertensive patients, and they were significantly higher in the hypertensive patients with diabetes. After treatment with efonidipine, the levels of PDMPs, CD62P-, CD63-, PAC-1-, and annexin V-positive platelets, sICAM-1, sVCAM-1, sP-selectin, and sE-selectin all decreased significantly. The MDMP levels decreased, and the decrease was significant in the hypertensive patients with diabetes. These findings suggest that administration of efonidipine to hypertension patients with diabetes may prevent the development of cardiovascular complications caused by cell adhesion molecules or activated platelets and monocytes.
Nomura
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First Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan. shosaku-n@mbp.sphere.ne.jp
Kanazawa
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Fukuhara
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D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001772:Blood Cell Count; D015815:Cell Adhesion Molecules / Q000097:blood / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D004095:Dihydropyridines / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects*; D009596:Nitrophenols / Q000494:pharmacology* / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000627:therapeutic use*; D015539:Platelet Activation / Q000187:drug effects*; D014652:Vascular Diseases / Q000097:blood / Q000209:etiology* / Q000517:prevention & control*
D000959:Antihypertensive Agents; D015815:Cell Adhesion Molecules; D004095:Dihydropyridines; D009596:Nitrophenols; D009943:Organophosphorus Compounds; C066425:efonidipine