title: Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats.
abstract: OBJECTIVE
  To investigate the effects and the possible mechanism of sesame oil on multiple organ failure induced by lipopolysaccharide in rats.
  
  
  METHODS
  Laboratory in vivo study of the effects of sesame oil on serum aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, lipid peroxide, and nitric oxide concentrations. To assess the effect of sesame oil on xanthine oxidase, serum uric acid was measured. Furthermore, lipid peroxide concentrations in liver and kidney were determined.
  
  
  METHODS
  University laboratory.
  
  
  METHODS
  Male Wistar rats.
  
  
  METHODS
  Blood testing.
  
  
  RESULTS
  Serum aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, and uric acid concentrations were determined. Lipid peroxide was analyzed by using a commercial kit. Nitric oxide production was estimated by Griess reaction. Sesame oil ameliorated hepatic and renal damage in a dose-dependent manner and increased animal survival in lipopolysaccharide-treated rats. Sesame oil decreased lipid peroxide concentration in serum but not in liver and kidney. Serum nitrite production was unaffected by sesame oil ingestion. Furthermore, the activity of xanthine oxidase was reduced by sesame oil in lipopolysaccharide-challenged rats.
  
  
  CONCLUSIONS
  Sesame oil ameliorated multiple organ failure and mortality via its inhibition of xanthine oxidase in lipopolysaccharide-dosed rats. Xanthine oxidase may play a critical role in sesame oil-associated organ protection during endotoxemia in rats.
authors.affiliation: Graduate Institute of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019446:Endotoxemia / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D007668:Kidney / Q000098:blood supply / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood; D008070:Lipopolysaccharides / Q000009:adverse effects; D008099:Liver / Q000098:blood supply / Q000378:metabolism; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D009569:Nitric Oxide / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012715:Sesame Oil / Q000494:pharmacology*; D016019:Survival Analysis; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D008054:Lipid Peroxides; D008070:Lipopolysaccharides; D014527:Uric Acid; D009569:Nitric Oxide; D012715:Sesame Oil