title: The reaction of nitric oxide with glutathionylcobalamin.
abstract: UV-vis stopped-flow results show that glutathionylcobalamin can react with nitric oxide at pH 7 to form nitrosylcob(II)alamin in a reaction second-order overall. From kinetic studies we suggest that nitric oxide attacks glutathionylcobalamin to form a caged transition state followed by formation of the nitrosylcob(II)alamin.
authors.affiliation: Department of Chemistry and Center for Analysis of Structures and Interfaces (CASI), The City College of New York, and The Graduate School and University Center of The City University of New York, New York, New York 10031, USA.
authors.forename: Donghong
authors.initials: D
authors.lastname: Zheng
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Birke
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D005978:Glutathione / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000737:chemistry*; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C064617:glutathionylcobalamin; D009569:Nitric Oxide; D005978:Glutathione; D014805:Vitamin B 12