Toxic and carcinogenic effects of parenteral and percutaneous ATP and its iron complex.
The long term effects of percutaneous, subcutaneous and intraperitoneal administration of sodium-ATP (NaATP) and ferric iron-ATP (FeATP) were studied on an animal model. Both compounds induce a generalized lymphoadenitis which in the case of FeATP led to lymphomas. The analytical study of the involved target tissues showed intracellular composition changes that result from the impairment of the cell membrane permeability. The morbidity and mortality rate were higher with FeATP which seems to be the result of two different, in intensity and duration, interactions with the cell plasma membrane. The influence of the changes in cellular calcium homeostasis, and its relationship with carcinogenesis and immuno response are discussed.
Anghileri
Leopold J
LJ
Biophysics Laboratory, Faculty of Medicine, University of Nancy Medical Center, University of Nancy, Nancy, France. leopoldanghileri@wana.doo.fr
Mayayo
Emilio
E
Domingo
José L
JL
Thouvenot
Pierre
P
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000633:toxicity*; D000279:Administration, Cutaneous; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry / Q000633:toxicity*; D007263:Infusions, Parenteral; D007279:Injections, Subcutaneous; D051379:Mice; D010539:Permeability; D012964:Sodium
D005290:Ferric Compounds; D000255:Adenosine Triphosphate; D012964:Sodium