Smad about E2F. TGFbeta repressionof c-Myc via a Smad3/E2F/p107 complex.
Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and the Rb-related factor p107.
Kowalik
Timothy F
TF
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D050704:E2F4 Transcription Factor; D005786:Gene Expression Regulation / Q000187:drug effects*; D046911:Macromolecular Substances; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D051900:Smad3 Protein; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D004268:DNA-Binding Proteins; D050704:E2F4 Transcription Factor; D046911:Macromolecular Substances; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc; D051900:Smad3 Protein; D015534:Trans-Activators; D014157:Transcription Factors; D016212:Transforming Growth Factor beta