Neuropathologic findings in a Guillain-Barré patient with strokes after IVIg therapy.
Strokes have been rarely associated with immunoglobulin G (IVIg) therapy. A 70-year-old woman with stable polycythemia vera developed Guillain-Barré syndrome and received IVIg, 8 days following which she became comatose due to bilaterally symmetric cerebral infarcts. Autopsy showed intravascular aggregates of fibrin-IgG but also platelets and a necrotizing microangiopathy in the infarcts.
Byrne
N P
NP
Department of Pathology and Laboratory Medicine (Neuropathology), School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Henry
J C
JC
Herrmann
D N
DN
Abdelhalim
A N
AN
Shrier
D A
DA
Francis
C W
CW
Powers
J M
JM
D000368:Aged; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use*; D020521:Stroke / Q000209:etiology* / Q000473:pathology*
D016756:Immunoglobulins, Intravenous