title: The activity of p-methoxybenzylisothiocyanate against Neisseria gonorrhoeae, Haemophilus ducreyi, and other microorganisms.
abstract: p-Methoxybenzylisothiocyanate was isolated from Lepidium bonariense and found to be responsible for the plants antimicrobial and STD activity. MIC determinations were conducted for p-methoxybenzylisothiocyanate on Haemophilus ducreyi, Neisseria gonorrheae, Candida albicans, Bacillus subtilus, Micrococcus luteus, Staphylococcus aureus, Enterobacter sp., Escherichia coli, Klebsiella pneumoniae, and Psuedomanas aeruginosa. An in vitro cellular toxicity assay showed that at 100 microM (17,9 microg/mL) p-methoxybenzylisothiocyanate is not toxic to living cells.
authors.affiliation: Pharmaceutical Chemistry, Potchefstroomse Universiteit vir Christelike Hoër Onderwys, Potchefstroom, South Africa. fchhs@puknet.puk.ac.za
authors.forename: Henk
authors.initials: H
authors.lastname: Swart
authors.forename: Sandra
authors.initials: S
authors.lastname: Van Dyk
authors.forename: Sarel F
authors.initials: SF
authors.lastname: Malan
mesh_terms: D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006191:Haemophilus ducreyi / Q000187:drug effects*; D017879:Isothiocyanates / Q000302:isolation & purification / Q000494:pharmacology*; D029686:Lepidium / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D028321:Plant Preparations / Q000494:pharmacology
chemical_list: D017879:Isothiocyanates; D028321:Plant Preparations; C475723:p-methoxybenzylisothiocyanate