Structural effects of dinotefuran and analogues in insecticidal and neural activities.
The insecticidal potencies of dinotefuran and analogues against the adult male American cockroach, Periplaneta americana (L) were measured by injection with or without metabolic inhibitors. The potency of dinotefuran was close to those of clothianidin and imidacloprid under the conditions used. The nerve-excitatory and nerve-blocking activities were measured with central nerve cords of P americana. The nerve-excitatory activity of dinotefuran was lower than that of imidacloprid, but was comparable with that of clothianidin. The nerve-blocking activity of dinotefuran was comparable with that of imidacloprid and slightly higher than that of clothianidin. Quantitative analyses showed that variations in the insecticidal activity were better correlated with variations in the nerve-blocking activity than with those in the nerve-excitatory activity when the contribution of the hydrophobic factor was allowed for.
Kiriyama
Kazuhisa
K
Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan. kiri@biochem.osakafu-u.ac.jp
Nishimura
Keiichiro
K
D000818:Animals; D006146:Guanidines / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D016015:Logistic Models; D015394:Molecular Structure; D000073943:Neonicotinoids; D009420:Nervous System / Q000187:drug effects*; D009574:Nitro Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D010526:Periplaneta / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D013997:Time Factors
D006146:Guanidines; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C465368:dinotefuran