title: Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man.
abstract: Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits.
authors.affiliation: Centre de Biologie du Développement, Université Paul Sabatier, 31062, Toulouse Cedex, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Boube
authors.forename: Laurent
authors.initials: L
authors.lastname: Joulia
authors.forename: David L
authors.initials: DL
authors.lastname: Cribbs
authors.forename: Henri-Marc
authors.initials: HM
authors.lastname: Bourbon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D005057:Eukaryotic Cells; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D012319:RNA Polymerase II / Q000737:chemistry / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics
chemical_list: D005656:Fungal Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II