title: Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease.
abstract: OBJECTIVE
  The watershed cortical areas are the first to be deprived of sufficient blood flow in the event of cerebral hypoperfusion and will be the sites of watershed microinfarcts. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed cortical infarcts in AD is lacking.
  
  
  METHODS
  Brains of 184 autopsy cases (105 definite AD cases and 79 age-matched controls) were selected and analyzed by histochemical and immunohistochemical techniques. The 3-dimensional reconstruction of the whole cerebrum, with 3-mm spaced serial sections, was performed in 6 AD cases to study the intrahemispheric and interhemispheric distribution of the cortical microinfarcts.
  
  
  RESULTS
  A significant association (P=0.001) was found between the occurrence of watershed cortical infarcts and AD (32.4% versus 2.5% in controls). The microinfarcts were restricted to the watershed cortical zones. Congophilic angiopathy was revealed to be an important risk factor. Perturbed hemodynamic factors (eg, decreased blood pressure) may play a role in the genesis of cortical watershed microinfarcts.
  
  
  CONCLUSIONS
  In AD, cerebral hypoperfusion induces not only white matter changes but cortical watershed microinfarcts as well, further aggravating the degenerative process and worsening dementia. To prevent the formation of watershed cortical microinfarcts in AD, monitoring blood pressure and treating arterial hypotension are essential.
authors.affiliation: University Institute of Pathology, Division of Neuropathology, University Medical School, University of Lausanne, Lausanne, Switzerland.
authors.forename: Oda-Christina
authors.initials: OC
authors.lastname: Suter
authors.forename: Thanomphone
authors.initials: T
authors.lastname: Sunthorn
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kraftsik
authors.forename: Joel
authors.initials: J
authors.lastname: Straubel
authors.forename: Pushpa
authors.initials: P
authors.lastname: Darekar
authors.forename: Kamel
authors.initials: K
authors.lastname: Khalili
authors.forename: Judith
authors.initials: J
authors.lastname: Miklossy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology*; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged