title: A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine.
abstract: Cyclosporine A (CsA), the most frequently used immunosuppressive drug, has been reported to induce cancer by a cell-autonomous mechanism. Herein, we report that FTY720, a novel immunosuppressant, prevents CsA-induced alterations in both morphology and cell motility at a low concentration (0.1 microM) and induces the CsA-treated cancer cells to undergo apoptosis at a higher concentration (more than 5 microM). The inhibitory activity of FTY720 is unrelated to the decrease of TGF-beta. We believe that a combination treatment with FTY720 and CsA not only results in a synergistic effect on allografts, but also, reduces the incidence of cancer in transplant patients.
authors.affiliation: Department of Urology, Gunma University School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shiro
authors.initials: S
authors.lastname: Takahara
authors.forename: Motoaki
authors.initials: M
authors.lastname: Hatori
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Ichimaru
authors.forename: Seiichi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kunio
authors.initials: K
authors.lastname: Morozumi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okuyama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yamanaka
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D016572:Cyclosporine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology*; D013110:Sphingosine / Q000031:analogs & derivatives; D016212:Transforming Growth Factor beta / Q000502:physiology; D014407:Tumor Cells, Cultured
chemical_list: D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D016212:Transforming Growth Factor beta; D016572:Cyclosporine; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine