Emergence of an influenza B virus with antigenic change.
Influenza B virus Yamagata group strains, isolated in the 2000 to 2001 influenza epidemic season, reacted poorly to the polyclonal ferret sera prepared against strains isolated earlier. The results of genetic analysis clarified that a point mutation of the nucleotide at position 126 in the HA1 region and the corresponding one-amino-acid substitution altered viral antigenicity.
Nakagawa
Naoko
N
Department of Parasitic Agents, Kobe Institute of Health, 4-6, Minatojima-nakamachi, Japan. kih-info-1@mse.biglobe.ne.jp
Nukuzuma
Souichi
S
Haratome
Shigekazu
S
Go
Shosan
S
Nakagawa
Toshimasa
T
Hayashi
Kozaburo
K
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D000940:Antigenic Variation / Q000235:genetics*; D000956:Antigens, Viral / Q000235:genetics; D004196:Disease Outbreaks; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry / Q000235:genetics; D006801:Humans; D009981:Influenza B virus / Q000235:genetics* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D007564:Japan / Q000453:epidemiology; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D000956:Antigens, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus