In vivo active antimalarial isonitriles.
Building on the lead from antimalarial isonitriles 1-4 of marine origin, several easily accessible synthetic isonitriles were assessed for their antimalarial activity against Plasmodium falciparum (in vitro) and multidrug resistant Plasmodium yoelii in Swiss mice model (in vivo). Isonitrile 11 has shown promising activity in both these assays.
Singh
Chandan
C
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India. chandancdri@yahoo.com
Srivastav
Naveen Chandra
NC
Puri
Sunil K
SK
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D051379:Mice; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology*; D018512:Parasitemia / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects; D010967:Plasmodium yoelii / Q000187:drug effects; D011161:Porifera / Q000737:chemistry; D013329:Structure-Activity Relationship
D000962:Antimalarials; D009570:Nitriles