title: Enhancement of dissolution rate and anti-inflammatory effects of piroxicam using solvent deposition technique.
abstract: Piroxicam solid depositions were prepared by means of the solvent deposition technique using different concentrations of microcrystalline cellulose as carrier material. The solvent deposition system (SDS) with drug to carrier ratio of 1:9 had a rapid dissolution rate in vitro. When this SDS was administered perorally to rats with a previous experimentally induced inflammation in their paws, it exhibited a pronounced anti-inflammatory action. X-ray diffraction and infrared (IR) spectroscopy showed no differences in the crystal state of piroxicam in SDS formulation and physical mixture of piroxicam and carrier. The increase in the dissolution rate and consequent enhancement of anti-inflammatory effect of piroxicam in SDS were attributed to the reduced particle size of drug deposited on the carrier and enhanced wettability of the particles brought about by the carrier.
authors.affiliation: Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Barzegar-Jalali
authors.forename: N
authors.initials: N
authors.lastname: Maleki
authors.forename: A
authors.initials: A
authors.lastname: Garjani
authors.forename: A A
authors.initials: AA
authors.lastname: Khandar
authors.forename: M
authors.initials: M
authors.lastname: Haji-Hosseinloo
authors.forename: R
authors.initials: R
authors.lastname: Jabbari
authors.forename: S
authors.initials: S
authors.lastname: Dastmalchi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D002482:Cellulose; D005260:Female; D005534:Foot Diseases / Q000188:drug therapy / Q000662:veterinary; D007249:Inflammation; D010316:Particle Size; D010894:Piroxicam / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051381:Rats; D012995:Solubility; D012997:Solvents; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012997:Solvents; D010894:Piroxicam; D002482:Cellulose