Permeability and stability of chitosan-based capsules: effect of preparation.
Capsules were obtained by interpolymer complexation between chitosan (polycation) and sodium hexametaphosphate (oligoanion). The effect of preparation variables such as the pH, ionic strength as well as the reagent and porogen concentration on the capsule characteristics was evaluated. By decreasing the chitosan/SMP ratio, adding mannitol up to 1% or maintaining the salt concentrations below 0.15 w/v%, the diffusion characteristics can be modulated without disturbing the capsule mechanical stability. Higher concentrations of the cross-linking agent (2.25 w/v%) produced stable capsules only in the absence of electrolyte and low polyol amounts. Furthermore, by increasing the ionic strength, or the pH of the initial chitosan solution, the membrane exclusion limit shifted to higher values concomitant with a significant loss in the membrane compression resistance. The results obtained showed that the capsule characteristics could be independently controlled by manipulating the coacervation conditions.
Angelova
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Laboratory of Polyelectrolytes and BioMacromolecules, Department of Chemistry, Swiss Federal Institute of Technology, 1015, Lausanne, Switzerland. nela.anguelova@epfl.ch
Hunkeler
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D002214:Capsules; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry*; D048271:Chitosan; D003911:Dextrans / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D005079:Excipients; D006245:Hardness Tests; D008353:Mannitol / Q000737:chemistry; D008970:Molecular Weight; D010539:Permeability; D016062:Porosity
D002214:Capsules; D003911:Dextrans; D005079:Excipients; D002686:Chitin; D008353:Mannitol; D048271:Chitosan