Caffeine microparticles for nasal administration obtained by spray drying.
This study investigated the possibility to use spray drying technique to prepare powders formulations containing caffeine intended for nasal delivery. Spray dried powders containing caffeine and excipients, as filler and shaper agents, were prepared. Powders were investigated for particle size, morphology and delivery properties from Monopowder P nasal insufflator, assessing the influence of each excipient on microparticles characteristics. The results showed that the excipients strongly affected microparticle properties. Size, shape and agglomeration tendency are relevant characteristics of spray dried nasal powder.
Sacchetti
C
C
Department of Pharmacy, University of Parma, Parco Area delle Scienze 27/A, Parma, Italy.
Artusi
M
M
Santi
P
P
Colombo
P
P
D000281:Administration, Intranasal; D002110:Caffeine / Q000008:administration & dosage*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D004339:Drug Compounding; D005079:Excipients; D007785:Lactose / Q000031:analogs & derivatives*; D008353:Mannitol; D008747:Methylcellulose / Q000031:analogs & derivatives*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010078:Oxazines; D010316:Particle Size; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D011208:Powders
D000697:Central Nervous System Stimulants; D005079:Excipients; D010078:Oxazines; D014677:Pharmaceutical Vehicles; D011208:Powders; D002110:Caffeine; D008353:Mannitol; D011092:Polyethylene Glycols; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose