title: Colorectal distention induces hippocampal noradrenaline release in rats: an in vivo microdialysis study.
abstract: We tested our hypothesis that noradrenaline is released in the hippocampus by colorectal distention of rats, and that it induces pain-related behavior. Noradrenaline levels with colorectal distention were significantly higher than those with restraint stress and free moving. Abdominal contractions were induced only by colorectal distention. Our results suggest that noradrenaline levels increase in the hippocampus under colorectal distention and this may relate to behavioral changes.
authors.affiliation: Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Saito
authors.forename: Motoyori
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Shin
authors.initials: S
authors.lastname: Fukudo
mesh_terms: D000009:Abdominal Muscles / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002404:Catheterization; D002851:Chromatography, High Pressure Liquid; D003106:Colon / Q000502:physiology*; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009119:Muscle Contraction / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum / Q000502:physiology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism
chemical_list: D009638:Norepinephrine