[Role of antiphospholipid antibodies in 147 patients with spontaneous abortions and stillbirths: a retrospective and prospective analysis].
Antiphospholipid antibodies (aPL) are a family of autoantibodies including lupus anticoagulant (LA), anticardiolipin antibodies (aCL), and ect. That appear to react with negatively charged phospholipids. These antibodies induce thrombosis and pregnancy complications including recurrent spontaneous abortions (RSA), recurrent stillbirth (SB), preeclampsia and intra-uterine growth retardation, although their exact pathogenic mechanisms remain poorly defined. The aim of this study was to investigate the frequency and the role of a aPL women with a history of RSA and SB due to positive aPL. The study included 147 women with a history of RSA and 48 women with a history of SB and to investigate the histological changes in the heams and stillborn fetuses in aCL positive women. We established that: 1, aCL were significantly increased in 62.2% (n = 92) in women with history of RSA and in 71% (n = 34) in women with history of SB; 2. aTr antibodies were positive in 22.7% (n = 5) in women with history of SB; 3. Tr activation status was increased in 77.3% (n = 17) in women with history of SB.


CONCLUSIONS
The investigation of aPL in women with history of RSA and SB provides new insights into the disease and offers promise for prophylaxis and treatment in subsequent pregnancies.
Ivanova
I
I
Konova
E
E
Popov
I
I
Petrova
P
P
Beer
A
A
D000026:Abortion, Habitual / Q000150:complications / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000502:physiology*; D005260:Female; D005313:Fetal Death / Q000276:immunology* / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies
D017152:Antibodies, Antiphospholipid