title: Papillary solid and cystic pancreatic tumor. Genetic prediction factors for malignancy: report of three cases.
abstract: BACKGROUND
  Papillary solid and cystic pancreatic tumor (PSCPT) is a rare neoplasm of unknown pathogenesis, with an excellent overall prognosis after complete resection. The malignant potential of this tumor remains unclear and was the object of our investigation.
  
  
  METHODS
  We report three cases of PSCPT submitted to radical resection in which histological and immunohistochemical studies, as well as genetic analysis of Kirsten-ras (K-ras) oncogene mutations, p53 and Fragile Histidine Triad (FHIT) gene expression, were evaluated.
  
  
  RESULTS
  Low expression of Ki 67 was consistent with a low karyokinetic index of these tumors. Mutations of the K-ras gene were not present. Low-grade variations of p53, K-ras and FHIT genes were detected by immunohistochemistry.
  
  
  CONCLUSIONS
  PSCPT is a rare neoplasm with low malignancy. Further genetic analysis is required to predict the potential malignancy of this tumor; nevertheless combined multimodality approaches may play a suitable role in identifying more aggressive forms.
authors.affiliation: Department of Surgery P. Valdoni, University of Rome La Sapienza, Italy. antonino.cavallaro@uniroma1.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Brozzetti
authors.forename: Deborah
authors.initials: D
authors.lastname: French
authors.forename: Andrea
authors.initials: A
authors.lastname: Polistena
authors.forename: Luca
authors.initials: L
authors.lastname: Di Marzo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Pisani
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Marchese
authors.forename: Pietro
authors.initials: P
authors.lastname: Mingazzini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Mascioli
authors.forename: Aldo
authors.initials: A
authors.lastname: Vecchione
authors.forename: Antonino
authors.initials: A
authors.lastname: Cavallaro
mesh_terms: D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000601:surgery; D004247:DNA / Q000097:blood / Q000235:genetics; D005260:Female; D011905:Genes, ras; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis / Q000235:genetics; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000601:surgery; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53; D004247:DNA