Dermatomyositis associated with membranous nephropathy in a 43-year-old female.
A 43-year-old woman was admitted to our hospital for myalgic pain and erythema of the face and thighs. She had been diagnosed with dermatomyositis at another hospital 8 years earlier and proteinuria had developed suddenly. Renal histological examination revealed membranous nephropathy. Membranous nephropathy associated with dermatomyositis is very rare. To date, malignant disease has not been detected in our patient, but the serum level of CA125, a tumor marker, has been elevated to 1,097 U/ml. The increased CA125 level is related to the degree of proteinuria and after prednisolone and cyclosporine therapy, proteinuria and the CA125 level gradually decreased.
Akashi
Yoshihiro
Y
Department of Internal Medicine, Kinashi Ohbayashi Hospital, Kagawa, Japan. akashi16@excite.co.jp
Inoh
Masayuki
M
Gamo
Naoyuki
N
Kinashi
Makoto
M
Ohbayashi
Seiichi
S
Miyake
Hayashi
H
Kurata
Noriyuki
N
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011507:Proteinuria / Q000097:blood / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone