Cyclosporine A protects against apoptosis in ischaemic/reperfused rat kidneys.
1. Renal ischaemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allografts. Cyclosporine A (CsA) has been used as an immunosuppressive agent in organ transplantation. In the present study, the effect of CsA on ischaemia/reperfusion-induced apoptosis in the kidney was investigated. 2. Ischaemia/reperfusion injury caused widespread apoptosis primarily in the medulla of the kidney. At 1.5 mg/kg per day, CsA significantly reduced the number of apoptotic cells in rat kidney after ischaemia/reperfusion injury. 3. Low-dose CsA treatment did not affect the levels of creatinine in the serum of rats after ischaemia/reperfusion injury.
Zhu
Tongyu
T
Department of Pharmacology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China.
Au-Yeung
Kathy K W
KK
Siow
Yaw L
YL
Wang
Guoping
G
O
Karmin
K
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology
D016572:Cyclosporine