DRB1*14 diversity and DRB3 associations in four major population groups in the United States.
At least 59 DRB1*14 positive individuals from each of four U.S. population groups, Caucasoids, African Americans, Asians/Pacific Islanders, and Hispanics, were randomly selected from a database of 82,979 individuals. DRB1*14 alleles were identified by DNA sequence analysis using intron-specific primers to obtain complete exon 2 sequences. Only 23% of the known DRB1*14 alleles were detected. DRB1*14011 was the predominant DRB1*14 allele in three populations while Hispanics carried DRB1*1402 and DRB1*1406 more frequently. Asians/Pacific Islanders were the most diversified carrying seven alleles. DRB3*0101, DRB3*02021 and DRB3*0210 were detected in a subset of individuals typed for this locus and 15 DRB1-DRB3 haplotypes were defined. This study completes the exon 2 sequences of previously identified alleles, DRB1*1405-*1408, including the identification of two silent codon 90 variants of DRB1*1407. In addition, two new DRB1*14 alleles, DRB1*1441 and DRB1*1442, are described.
Gans
C P
CP
Georgetown University Medical Center, Washington, DC 20057, USA.
Tang
T F
TF
Slack
R
R
Ng
J
J
Hartzman
R J
RJ
Hurley
C K
CK
D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D005091:Exons; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D014481:United States; D044465:White People / Q000235:genetics; D001741:Black or African American
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains