CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women.
The frequency of CYP1A1 (CYP1A1*2A), GSTM1, and GSTT1 polymorphisms, as well as the main risk factors associated with breast cancer were studied in Brazilian women, with malignant breast cancer (n=128), or age-matched controls (n=256). Only a family history of breast cancer presented a significant risk (OR=3.00, CI=1.27-7.06). Among non-whites, the CYP1A1*2A allele was underrepresented among patients. Statistical analysis indicated that this polymorphism may decrease the risk of breast cancer among these individuals, particularly after adjusting for the risk presented by selected risk factors (OR=0.30, 95% CI=0.12-0.76).
da Fonte de Amorim
Lídia
L
Departamento de Biologia Celular e Molecular, IB, Universidade Federal Fluminense, Rio de Janeiro, Brazil.
Rossini
Ana
A
Mendonça
Gulnar
G
Lotsch
Priscila
P
de Almeida Simão
Tatiana
T
de Moura Gallo
Cláudia
C
Pinto
Luis
L
D000328:Adult; D000368:Aged; D001938:Brazil; D001943:Breast Neoplasms / Q000201:enzymology* / Q000209:etiology / Q000235:genetics; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1