The comparison between Behçet's disease and spondyloarthritides: does Behçet's disease belong to the spondyloarthropathy complex?
This study was to clarify whether Behcet's disease (BD) could be classified into the spondyloarthropathy (SpA) complex. It was undertaken on 58 patients with BD (BD group), 56 patients with SpA (SpA group), and 3 patients who concurrently satisfied the criteria for BD and SpA (BDSpA group). The clinical parameters and known susceptible HLA antigens were compared between BD group and SpA group. In addition, 3 patients in BDSpA group were reviewed. The prevalence of definitive sacroiliitis (SI) in BD group and SpA group was 46.4% and 5.2%, respectively. However, none had a definitive SI in healthy controls. Enthesitis was observed in 3.4% of BD group and in 50% of SpA group. The patterns of eye involvement were different between these two groups. HLA-B27 was negative in all 49 patients of BD group, whereas it was positive in 67.9% of SpA group. The prevalence of HLA-B51 was 51.7% in BD group, and that in SpA group was 21.4%. One patient in BDSpA group was considered to have concurrent BD and ankylosing spondylitis (AS). Another patient was closer to AS, and the third to BD. Conclusively, it seems that BD could not be classified into the SpA complex.
Chang
Hyun Kyu
HK
Division of Rheumatology, Department of Internal Medicine, Dankook University Hospital, Cheonan, Korea. hanks22@dankook.ac.kr
Lee
Deok Hee
DH
Jung
Seung Mun
SM
Choi
Soo Jung
SJ
Kim
Jeong Uk
JU
Choi
Young Joon
YJ
Baek
Seung Ki
SK
Cheon
Kyeong Soo
KS
Cho
Eun Hee
EH
Won
Kyoung Sook
KS
D000328:Adult; D001528:Behcet Syndrome / Q000145:classification* / Q000276:immunology / Q000473:pathology; D005123:Eye / Q000473:pathology; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis / Q000276:immunology; D015796:HLA-B27 Antigen / Q000032:analysis / Q000276:immunology; D059949:HLA-B51 Antigen; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D011849:Radioactive Tracers; D011859:Radiography; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging / Q000473:pathology; D025241:Spondylarthritis / Q000276:immunology / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D059949:HLA-B51 Antigen; D011849:Radioactive Tracers