title: Increased cerebral blood flow after brain arteriovenous malformation resection is substantially independent of changes in cardiac output.
abstract: Brain arteriovenous malformation (BAVM) resection can result in an acute increase in cerebral blood flow (CBF) of unclear etiology. This observational study investigated the relationship between changes in CBF and cardiac output (CO) in patients undergoing microsurgical resection of BAVMs. In 20 patients undergoing a BAVM resection during an isoflurane-based anesthesia, we measured CBF and systemic cardiovascular parameters immediately before and after BAVM resection. CBF was measured on the hemisphere ipsilateral to the lesions and on the contralateral side, using intravenous cold 133Xe washout. Cardiac output was measured using thermodilution technique via a pulmonary artery catheter. There was an increase in global CBF after resection (25 +/- 8 versus 31 +/- 13 mL/100 g/min, preresection versus postresection, mean +/- SD, P =.002), ipsilateral CBF (25 +/- 8 versus 31 +/- 13 mL/100 g/min, P =.002), and contralateral CBF (24 +/- 7 versus 30 +/- 13 mL/100 g/min, P =.003). There was no change in CO, mean systemic arterial pressure, central venous pressure, or pulmonary artery diastolic pressure. The change in CBFGLOBAL was not correlated with changes in CO (r =.154, P =.517). BAVM resection resulted in global increases in CBF that was not substantially related to changes in CO or other systemic parameters.
authors.affiliation: Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94110, USA.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Hashimoto
authors.forename: William L
authors.initials: WL
authors.lastname: Young
authors.forename: Isak
authors.initials: I
authors.lastname: Prohovnik
authors.forename: Dhanesh K
authors.initials: DK
authors.lastname: Gupta
authors.forename: Noeleen D
authors.initials: ND
authors.lastname: Ostapkovich
authors.forename: Eugene
authors.initials: E
authors.lastname: Ornstein
authors.forename: Alexander X
authors.initials: AX
authors.lastname: Halim
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Quick
mesh_terms: D000328:Adult; D002302:Cardiac Output / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D016343:Monitoring, Intraoperative; D019635:Neurosurgical Procedures; D011651:Pulmonary Artery / Q000503:physiopathology; D013815:Thermodilution; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes