InlB, a surface protein of Listeria monocytogenes that behaves as an invasin and a growth factor.
Molecules from some pathogenic bacteria mimic natural host cell ligands and trigger engulfment of the bacterium after specifically interacting with cell-surface receptors. The leucine-rich repeat (LRR)-containing protein InlB of Listeria monocytogenes is one such molecule. It triggers bacterial entry by interacting with the hepatocyte growth factor receptor (HGF-R or Met) and two other cellular components: gC1q-R and proteoglycans. Recent studies point to significant similarities between the molecular mechanisms underlying InlB-mediated entry into cells and classic phagocytosis. In addition, InlB, in common with HGF, activates signaling cascades that are not involved in bacterial entry. Therefore, studies of InlB may help us to analyze the previously noticed similarities between growth factor receptor activation and phagocytosis.
Bierne
Hélène
H
Unité des Interactions Bactéries-Cellules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris cedex 15, France.
Cossart
Pascale
P
D000199:Actins / Q000378:metabolism; D018829:Adhesins, Bacterial / Q000378:metabolism*; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D002352:Carrier Proteins; D003599:Cytoskeleton / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D018960:Hyaluronan Receptors; D008089:Listeria monocytogenes / Q000378:metabolism*; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D024101:Mitochondrial Proteins; D010587:Phagocytosis / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017433:Protein Structure, Secondary; D011509:Proteoglycans / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D011951:Receptors, Complement / Q000378:metabolism
D000199:Actins; D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C087299:C1QBP protein, human; D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011509:Proteoglycans; D011951:Receptors, Complement; C032402:complement 1q receptor; C095768:inlB protein, Listeria monocytogenes; C053476:invasin, Yersinia; D017228:Hepatocyte Growth Factor; D019869:Phosphatidylinositol 3-Kinases; D019859:Proto-Oncogene Proteins c-met