Growth hormone therapy for adults: not ready for prime time?
Human growth hormone is now readily available and approved for treatment of the growth hormone deficiency syndrome in adults. However, physicians have been slow to adopt this therapeutic modality. Reasons for skepticism about the use of growth hormone for the growth hormone deficiency syndrome include doubts about whether growth hormone deficiency causes increased morbidity and mortality in patients with hypopituitarism; availability of highly efficacious, easier to use, and less expensive agents for certain aspects of the growth hormone deficiency syndrome, especially cardiovascular disease; and concerns about possible toxicity in adults. Long-term studies in patients receiving appropriate comprehensive management for other hormonal deficiencies and for concomitant abnormalities will be required to convince physicians of the utility and safety of growth hormone replacement therapy.
Isley
William L
WL
University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA. wisley@saint-lukes.org
D000328:Adult; D001823:Body Composition / Q000187:drug effects; D003362:Cost-Benefit Analysis; D005260:Female; D020249:Hormone Replacement Therapy / Q000191:economics; D019382:Human Growth Hormone / Q000172:deficiency* / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000188:drug therapy / Q000401:mortality; D008055:Lipids / Q000097:blood; D008297:Male; D011306:Prescription Fees; D012307:Risk Factors; D013577:Syndrome
D008055:Lipids; D019382:Human Growth Hormone