title: In vivo active antimalarial isonitriles.
abstract: Building on the lead from antimalarial isonitriles 1-4 of marine origin, several easily accessible synthetic isonitriles were assessed for their antimalarial activity against Plasmodium falciparum (in vitro) and multidrug resistant Plasmodium yoelii in Swiss mice model (in vivo). Isonitrile 11 has shown promising activity in both these assays.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India. chandancdri@yahoo.com
authors.forename: Chandan
authors.initials: C
authors.lastname: Singh
authors.forename: Naveen Chandra
authors.initials: NC
authors.lastname: Srivastav
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Puri
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D051379:Mice; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology*; D018512:Parasitemia / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects; D010967:Plasmodium yoelii / Q000187:drug effects; D011161:Porifera / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D009570:Nitriles