Serum interleukin 1 alpha and interleukin 2 levels in patients with schizophrenia.
It has been suggested that altered interleukin (IL) regulation may be involved in the pathogenesis of schizophrenia. In this cross-sectional, case-controlled study, patients with schizophrenia and a control group of healthy subjects, matched by age, sex and body mass index, were evaluated. The levels of IL-1 alpha and IL-2 in blood serum were measured by enzyme-linked immunosorbent assay. The fasting serum IL-2 levels were significantly higher in patients with schizophrenia compared with the control subjects, but there was no difference between the fasting serum levels of IL-1 alpha in patients with schizophrenia and the control subjects. Our results suggest that patients with schizophrenia have altered IL-2, but not IL-1 alpha, regulation.
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Department of Psychiatry, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Istanbul, Turkey. tpcihan@superonline.com
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Oncül
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Başoğlu
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Cavuşlu
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Cetin
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D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D012559:Schizophrenia / Q000097:blood*
D007375:Interleukin-1; D007376:Interleukin-2