Antimicrobial flavonoids from Bolusanthus speciosus.
A new isoflavanone namely 3,5,7,2',4'-pentahydroxy-8,3'-di(gamma,gamma-dimethylallyl)isoflavanone (bolusanthin II) and four new pterocarpans identified as 3-hydroxy-6',6'-dimethylpyrano[2',3':1,2] [6a R,11a R]-8,9-methylenedioxypterocarpan (bolucarpan A), 3-hydroxy-6',6'-dimethyl-4',5'-dihydropyrano[2',3':1,2][6a R,11a R]- 8,9-methylenedioxypterocarpan (bolucarpan B), 3-hydroxy-9-methoxy-6',6'-dimethylpyrano-[2',3':1,2][6a R,11a R]-pterocarpan (bolucarpan C) and 3-hydroxy-9-methoxy-6',6'-dimethyl-4',5'-dihydropyrano[2',3':1,2][6a R,11a R]-pterocarpan (bolucarpan D) and three known isoflavonoids were isolated from the methanolic extracts of the root bark, while eight known isoflavonoids were isolated from the stem bark of Bolusanthus speciosus. These compounds showed antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae and Candida mycoderma using the agar overlay technique.
Bojase
Gomotsang
G
Department of Chemistry, University of Botswana, Gaborone, Botswana.
Majinda
Runner R T
RR
Gashe
Berhanu A
BA
Wanjala
Cornelius C W
CC
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005419:Flavonoids