[Th1-cytokines in chronic hepatitis B and C].
Forty-four patients with chronic HBV and HCV were observed. Serum levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and soluble IL-2 receptor (IL-2r) were measured by enzyme immunoassay in 29 patients divided into 3 groups: group 1 (n = 9) with chronic HBV, group 2 (n = 9) with chronic HCV, and group 3 (n = 11) with mixed HBV + HCV infection. Control group consisted of 10 normal subjects without HBV, HCV, or HIV infection markers. The most informative of Th1 cytokines was IL-2r: its concentration was increased significantly (p < 0.01) in all patients with hepatitis B and/or C in comparison with the control. In addition, there was a trend to an increase in the mean concentrations of IL-2r from group 1 to groups 2 and 3. The concentrations of IFH-gamma and IL-2 did not differ significantly in the patients and controls. However, the concentrations of IFN-gamma were increased significantly (p < 0.01) in comparison with the control in 3 patients from group 1 and 4 patients from group 3 with more pronounced inflammation.
Priĭmiagi
L S
LS
Tefanova
V T
VT
Tallo
T G
TG
Shmidt
E V
EV
Solomonova
O V
OV
Tuĭsk
T P
TP
Kikosh
G V
GV
Krupskaia
L M
LM
Lisitsyna
S A
SA
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology*; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma