title: Chemopreventive potential of cyclic diarylheptanoids.
abstract: Eleven cyclic diarylheptanoids and seven related compounds were screened as potential antitumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. In addition, the cyclic diarylheptanoid myricanone (2) was examined for antitumor initiating activity in a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA as a promoter. Myricanone (2) exhibited significant antitumor-initiating effect on mouse skin. These data suggest that cyclic, as well as linear, diarylheptanoids might be valuable chemopreventors.
authors.affiliation: Hoshi University, 2-4-41, Ebara, Shinagawa-ku, 142-8501, Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Ishida
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Kozuka
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Seiji
authors.initials: S
authors.lastname: Nagumo
authors.forename: Kuo Hsiung
authors.initials: KH
authors.lastname: Lee
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagai
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000187:drug effects; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015197:Carcinogenicity Tests; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000956:Antigens, Viral; D000970:Antineoplastic Agents; C033305:Epstein-Barr virus early antigen