New hydrogen donor: a facile method for the removal of hydrogenolysable protecting groups in Peptide synthesis.
Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and 10%Pd on carbon is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. This is more effective than hydrazine or formic acid.
Gowda
D Channe
DC
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Karnataka, India. dcgowda@yahoo.com
Mahesh
B
B
D000596:Amino Acids / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D005561:Formates / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D006859:Hydrogen; D007854:Lead / Q000737:chemistry*; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry
D000596:Amino Acids; D005561:Formates; D006834:Hydrazines; D010455:Peptides; C030544:formic acid; C007969:hydrazinium; C029424:hydrazine; D007854:Lead; D002244:Carbon; D006859:Hydrogen