[Eosinophil inflammation of the nasal mucosa].
BACKGROUND
Inflammatory diseases are very frequent and cause reasonable mortality. They are the major part in upper airway diseases in ENT. Eosinophil inflammation is a key feature in allergic rhinitis, asthma, nasal polyps and non-allergic rhinitis. The mechanism and the consequences of eosinophil inflammation are described in this review.


RESULTS
Eosinophils mature in bone marrow, mainly under the influence of IL-5 and eotaxin. Once mobilised to circulation, they accumulate in inflammatory sites by specific adhesion. VCAM-1 and other adhesion molecules are involved in this process. In the tissue, eosinophils get activated by different stimuli like immunoglobulin receptors and cytokines like IL-5. Activated eosinophils release toxic proteins, mediators and cytokines and thus trigger further inflammatory response. This leads to the late phase reaction and continuing inflammatory reaction. Eosinophils also interact with virus infections and have effects on nerve endings with the M2 receptor.


CONCLUSIONS
Eosinophil inflammation may be monitored via the determination of cationic proteins in nasal secretions. Corticosteroids are very effective in the treatment of eosinophil inflammation, and anti-IL-5 and anti-IL-4 antibodies seem to be effective, too.
Rasp
G
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Klinik und Poliklinik für Hals-, Nasen-, Ohrenkranke der Ludwig-Maximilians-Universität München. Rasp@hno.med.uni-muenchen.de
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D004802:Eosinophilia / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004804:Eosinophils / Q000187:drug effects / Q000473:pathology; D006801:Humans; D015847:Interleukin-4 / Q000037:antagonists & inhibitors; D015848:Interleukin-5 / Q000037:antagonists & inhibitors; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D012220:Rhinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D015848:Interleukin-5; D015847:Interleukin-4