title: Involvement of hedgehog, wingless, and dpp in the initiation of proximodistal axis formation during the regeneration of insect legs, a verification of the modified boundary model.
abstract: To understand the mechanism of regeneration, many experiments have been carried out with hemimetabolous insects, since their nymphs possess the ability to regenerate amputated legs. We first succeeded in observing expression patterns of hedgehog, wingless (wg), and decapentaplegic (dpp) during leg regeneration of the cricket Gryllus bimaculatus. The observed expression patterns were essentially consistent with the predictions derived from the boundary model modified by Campbell and Tomlinson (CTBM). Thus, we concluded that the formation of the proximodistal axis of a regenerating leg is triggered at a site where ventral wg-expressing cells abut dorsal dpp-expressing cells in the anteroposterior (A/P) boundary, as postulated in the CTBM.
authors.affiliation: Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Jyosanjima-cho, Tokushima City 770-8506, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Mito
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Inoue
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kimura
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miyawaki
authors.forename: Nao
authors.initials: N
authors.lastname: Niwa
authors.forename: Yohei
authors.initials: Y
authors.lastname: Shinmyo
authors.forename: Hideyo
authors.initials: H
authors.lastname: Ohuchi
authors.forename: Sumihare
authors.initials: S
authors.lastname: Noji
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002455:Cell Division; D029721:Drosophila Proteins / Q000502:physiology*; D005121:Extremities / Q000033:anatomy & histology / Q000502:physiology*; D006135:Gryllidae / Q000502:physiology*; D053823:Hedgehog Proteins; D008953:Models, Anatomic; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D012038:Regeneration; D013997:Time Factors; D051155:Wnt1 Protein
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C064196:dpp protein, Drosophila; C074622:wg protein, Drosophila; C077245:hh protein, Drosophila; D001973:Bromodeoxyuridine