Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine.
Spectroscopic evidence is presented for the formation of a carbinolamine interchain cross-link in 5'-CpG-3' sequences, arising from the acrolein adduct gamma-OH-PdG. This may be important in understanding biological processing of acrolein-induced DNA damage in CpG sequences.
Kim
Hye-Young H
HY
Department of Chemistry, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA.
Voehler
Markus
M
Harris
Thomas M
TM
Stone
Michael P
MP
D000171:Acrolein / Q000737:chemistry*; D018899:CpG Islands; D018736:DNA Adducts / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011688:Purinones / Q000737:chemistry*
D018736:DNA Adducts; D011688:Purinones; D000171:Acrolein