Wnt signaling involvement in beta-amyloid-dependent neurodegeneration.
Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-beta peptide (Abeta). We have observed that Abeta-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients.
Inestrosa
Nibaldo
N
Center for Cell Regulation and Pathology, P. Catholic University of Chile, P.O. Box 114-D, Alameda 340, Santiago, Chile. ninestr@genes.bio.puc.cl
De Ferrari
Giancarlo V
GV
Garrido
José L
JL
Alvarez
Alejandra
A
Olivares
Gonzalo H
GH
Barría
María I
MI
Bronfman
Miguel
M
Chacón
Marcelo A
MA
D016229:Amyloid beta-Peptides / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D006801:Humans; D009410:Nerve Degeneration / Q000503:physiopathology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D016229:Amyloid beta-Peptides; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins