In vitro activity of Melaleuca alternifolia (tea tree) oil against dermatophytes and other filamentous fungi.
The in vitro activity of Melaleuca alternifolia (tea tree) oil against dermatophytes (n = 106) and filamentous fungi (n = 78) was determined. Tea tree oil MICs for all fungi ranged from 0.004% to 0.25% and minimum fungicidal concentrations (MFCs) ranged from <0.03% to 8.0%. Time-kill experiments with 1-4 x MFC demonstrated that three of the four test organisms were still detected after 8 h of treatment, but not after 24 h. Comparison of the susceptibility to tea tree oil of germinated and non-germinated Aspergillus niger conidia showed germinated conidia to be more susceptible than non-germinated conidia. These data demonstrate that tea tree oil has both inhibitory and fungicidal activity.
Hammer
K A
KA
Department of Microbiology, The University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia. khammer@cyllene.uwa.edu.au
Carson
C F
CF
Riley
T V
TV
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects* / Q000302:isolation & purification; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D031650:Melaleuca; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D008517:Phytotherapy / Q000379:methods; D020947:Tea Tree Oil / Q000494:pharmacology*
D000935:Antifungal Agents; D020947:Tea Tree Oil