The effects of asphyxia on 5-hydroxytryptamine metabolism in the immature rat brain.
Five-day-old rats subjected to prolonged asphyxia at 37 degrees C show a slower rate of synthesis of 5-HT as measured by the accumulation of the amine after inhibition of monoamine oxidase. During recovery from asphyxia 5-HT synthesis is markedly stimulated when measured over a 50 or 90 min period. No change in 5-HT synthesis was observed in 5-day-old rats during recovery from cold exposure or immobilization. The results indicate that the persistent increase in synthesis that follows resuscitation may be related to asphyxia per se rather than to the stress component of the treatment.
Tricklebank
M D
MD
Department of Child Health, Medical School, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
Pickard
F J
FJ
Dobbing
J
J
D000818:Animals; D001237:Asphyxia / Q000188:drug therapy / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D003080:Cold Temperature; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D012151:Resuscitation; D012701:Serotonin / Q000378:metabolism*; D014191:Tranylcypromine / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D014191:Tranylcypromine