Mechanisms underlying geroprotective effects of peptides.
We review the role of peptides in aging and the mechanisms underlying the geroprotective effect of peptide preparations. Geroprotective properties of peptides are associated with their influence on systems maintaining homeostasis in the body and regulation of mechanisms underlying aging. Peptides normalize synthesis of tissue-specific proteins and regulate expression of genes responsible for proliferation and differentiation of cells. Thus, peptides maintain normal physiological functions and decelerate aging.
Khavinson
V Kh
VKh
St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences.
Malinin
V V
VV
D000375:Aging / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D005853:Geriatrics; D006801:Humans; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000502:physiology / Q000627:therapeutic use; D010455:Peptides / Q000502:physiology* / Q000627:therapeutic use
D009842:Oligopeptides; D010455:Peptides