Synthesis of lipophilic aldehydes and study of their inhibition effect on human digestive lipases.
[reaction: see text] Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.
Kotsovolou
Stavroula
S
Department of Chemistry, University of Athens, Panepistimiopolis, Greece.
Verger
Robert
R
Kokotos
George
G
D000447:Aldehydes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004064:Digestive System / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors*
D000447:Aldehydes; D004791:Enzyme Inhibitors; D008049:Lipase