Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment.
The purpose of this study was to investigate the relationship of changes in the enzyme-inducing anticonvulsant daily dosage (drug score) to variations in urinary D-glucaric acid excretion and gamma-glutamyltransferase and beta-glucuronidase serum activities. These biochemical determinations were carried out before and after a mean period of 5.0 years in 16 adult epileptic patients (8 men and 8 women) treated with phenobarbital, phenytoin and/or carbamazepine and with a good therapeutic compliance. A significant correlation between D-glucaric acid excretion and drug score was obtained (r=0.508, p<0.001). When the interindividual variation was diminished by assessing the changes of these variables in the same subjects, the correlation was better (r=0.836, p<0.001). However, a statistical significance was not attained between the gamma-glutamyltransferase or beta-glucuronidase and drug score changes. Therefore the urinary excretion of D-glucaric acid appears to be more sensitive to changes in anticonvulsant drug score than serum gamma-glutamyltransferase and beta-glucuronidase.
Hermida
Jesús
J
Laboratorio Central, Hospital Clínico Universitario, Santiago de Compostela, Spain.
Fernández
M Pilar
MP
Tutor
J Carlos
JC
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D002220:Carbamazepine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D005937:Glucaric Acid / Q000652:urine*; D005966:Glucuronidase / Q000097:blood / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D010672:Phenytoin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D012737:Sex Factors; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000187:drug effects
D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin; D005723:gamma-Glutamyltransferase; D005966:Glucuronidase; D005937:Glucaric Acid; D010634:Phenobarbital