title: Severe periodontitis in Marfan's syndrome: a case report.
abstract: BACKGROUND
  Connective tissue disorders, such as some forms of Ehlers-Danlos syndrome, have been associated with severe periodontitis.
  
  
  METHODS
  This report describes a case of Marfan's syndrome, an inherited disorder of connective tissue caused by mutations in the fibrillin-1 gene, in which the patient presented with severe periodontitis.
  
  
  RESULTS
  At examination, an average full-mouth clinical attachment level loss of 5.6+/-2.1 mm, furcation involvement, and severe alveolar bone loss were observed in a 41-year-old Caucasian male. Tooth hypermobility was also present.
  
  
  CONCLUSIONS
  This case appears to be the first documentation of severe periodontitis in a patient with Marfan's syndrome. It supports the hypothesis that a variety of connective tissue disorders may confer increased susceptibility to periodontal tissue breakdown.
authors.affiliation: Department of Periodontology, Eastman Dental Institute, University College, London, UK.
authors.forename: Antje M
authors.initials: AM
authors.lastname: Straub
authors.forename: Rodney
authors.initials: R
authors.lastname: Grahame
authors.forename: Crispian
authors.initials: C
authors.lastname: Scully
authors.forename: Maurizio S
authors.initials: MS
authors.lastname: Tonetti
mesh_terms: D000328:Adult; D002908:Chronic Disease; D000071838:Fibrillin-1; D000071837:Fibrillins; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications*; D008840:Microfilament Proteins / Q000235:genetics; D010518:Periodontitis / Q000209:etiology*; D054392:Adipokines
chemical_list: D000071838:Fibrillin-1; D000071837:Fibrillins; D008840:Microfilament Proteins; C000605722:FBN1 protein, human; D054392:Adipokines