title: [A study of the relationship between MICA gene and systemic lupus erythematosus].
abstract: OBJECTIVE
  To investigate the relationship between major histocompatibility complex class I chain-related A(MICA) gene and systemic lupus erythematosus (SLE).
  
  
  METHODS
  The alleles and frequencies of exons 4 and 5 of MICA gene were determined in 70 cases of SLE and 152 controls of Yunnan Hans by STR genotyping, polymerase chain reaction, single strand conformation polymorphism and bidirection DNA sequencing.
  
  
  RESULTS
  Five alleles of exon 5 and 10 alleles of exon 4 were found in this study. The frequency of each allele was determined in patients and controls. There was no significant difference between the two groups in exons 4 and 5 of MICA gene.
  
  
  CONCLUSIONS
  Exons 4 and 5 of MICA were not related to SLE in Yunnan Hans.
authors.affiliation: Department of Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan, 650118 P.R. China. chujy@public.km.yn.cn
authors.forename: Guihong
authors.initials: G
authors.lastname: Ban
authors.forename: Jiayou
authors.initials: J
authors.lastname: Chu
authors.forename: Changzhi
authors.initials: C
authors.lastname: Mao
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Yang
authors.forename: Shaobin
authors.initials: S
authors.lastname: Xu
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Chu
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Huang
authors.forename: Sizhong
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D002681:China; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D004247:DNA