[Analysis on polymorphism in exons 2,3 and 4 of the MICA gene in three different Chinese populations].
OBJECTIVE
To detect genetic polymorphism in the exons 2 to 4 of the MICA gene in Chinese Han population in Shanghai, Dai population in Yunnan province and Uygur population in Xinjiang province respectively.


METHODS
DNA samples from 183 random healthy individuals in Han population, 41 in Dai population and 66 in Uygur population were genotyped by using the polymerase chain reaction (PCR) and sequence-specific oligonucleotide probing (SSOP) method.


RESULTS
In total, 10, 7 and 9 alleles of MICA were observed in Han, Dai and Uygur population respectively. MICA*008 was the most common allele in the population of both Han and Uygur, whereas MICA*010 was the most popular one in Dai population. Han and Dai had a bit similar distribution pattern (Chi-square=12.809  P=0.046), in contrast with Han to Uygur (Chi-square=58.499  P=0) and Dai to Uygur (Chi-square=49.273  P=0).


CONCLUSIONS
MICA gene displayed different allele distributions in different populations.
Gong
Weijuan
W
Shanghai Second Medical University, Shanghai Institute of Immunology, Shanghai,200025 P.R.China. Lian-Fan@online.sh.cn
Fan
Li'an
L
Yang
Jueqin
J
Xu
Lingdi
L
Yao
Fangjuan
F
D000483:Alleles; D002681:China; D005091:Exons / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D005843:Geography; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A