Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats.
In the present study, we have investigated the microsomal linoleic acid desaturation steps into arachidonic acid in 10- and 30-day-old spontaneously hypertensive rats (SHR), as compared to their normotensive control rats, Wistar Kyoto (WKY). Suckled by adoptive Wistar normotensive female, the SHR and WKY were fed the same diet. Our results show lower Delta 6 and Delta 5 desaturase activities (the limiting steps in the bioconversion of linoleic acid into arachidonic acid) in the young SHR, as compared to the WKY normotensive rats. The fatty acid composition of liver microsomal total lipids evidences a higher proportion of linoleic acid in SHR than in WKY, in agreement with the partially depleted desaturase activities. Such a loss of desaturase activities may be under the control of hormones involved in the regulation of SHR blood pressure.
Savelli
J L
JL
Université de Corse, BP 52, Corté, France.
Narce
M
M
Fustier
V
V
Poisson
J-P
JP
D000818:Animals; D016718:Arachidonic Acid / Q000096:biosynthesis; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003627:Data Interpretation, Statistical; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005260:Female; D006973:Hypertension / Q000201:enzymology*; D008041:Linoleic Acids / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors; D014886:Weaning
D001786:Blood Glucose; D008041:Linoleic Acids; D016718:Arachidonic Acid; D044943:Fatty Acid Desaturases