title: Regulation of acetylcholine synthesis and storage.
abstract: Acetylcholine is one of the major modulators of brain functions and it is the main neurotransmitter at the peripheral nervous system. Modulation of acetylcholine release is crucial for nervous system function. Moreover, dysfunction of cholinergic transmission has been linked to a number of pathological conditions. In this manuscript, we review the cellular mechanisms involved with regulation of acetylcholine synthesis and storage. We focus on how phosphorylation of key cholinergic proteins can participate in the physiological regulation of cholinergic nerve-endings.
authors.affiliation: Laboratório de Neurofarmacologia, Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Avenue Antonio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. mprado@icb.ufmg.br
authors.forename: Marco A M
authors.initials: MA
authors.lastname: Prado
authors.forename: Ricardo A M
authors.initials: RA
authors.lastname: Reis
authors.forename: V F
authors.initials: VF
authors.lastname: Prado
authors.forename: Maria Christina
authors.initials: MC
authors.lastname: de Mello
authors.forename: Marcus V
authors.initials: MV
authors.lastname: Gomez
authors.forename: Fernando G
authors.initials: FG
authors.lastname: de Mello
mesh_terms: D000109:Acetylcholine / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins; D013572:Synaptic Vesicles / Q000201:enzymology / Q000378:metabolism; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins
chemical_list: D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C493459:SLC18A3 protein, human; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins; D002795:Choline O-Acetyltransferase; D000109:Acetylcholine