title: [One case of locally advanced breast cancer in which multidisciplinary treatment, chiefly, therapy with preoperative intraarterial infusion of docetaxel (TXT), was successful].
abstract: We herein report 1 case in which hormone therapy and neoadjuvant chemotherapy by local intraarterial infusion were conducted for locally advanced breast cancer, and were revealed to be useful in terms of local control. Administration of doxifluridine (5'-DFUR: Furtulon) (1,200 mg/day, 5 day continuous dosing followed by 2 day washout) and medroxyprogesterone acetate (MPA: Hysron H) (1,200 mg/day) was followed by chemotherapy consisting of intraarterial infusion of 100 mg of docetaxel (TXT: Taxotere), once monthly, via the left internal thoracic artery and left lateral thoracic artery. As a result, marked shrinkage of tumors was confirmed. Under these circumstances, left standard radical mastectomy plus skin grafting were performed. While under treatment, no serious adverse events were observed, and the patient made satisfactory progress after surgical procedure. She thus left hospital in a positive frame of mind.
authors.affiliation: Dept. of Digestive/General Surgery, Saiseikai-Affiliated Suita Hospital.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Harada
authors.forename: Akinori
authors.initials: A
authors.lastname: Hara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsunematsu
authors.forename: Chie
authors.initials: C
authors.lastname: Matsubara
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Izumi
authors.forename: Shinji
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Kazunari
authors.initials: K
authors.lastname: Satake
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy* / Q000601:surgery; D000077143:Docetaxel; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D017239:Paclitaxel / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D043823:Taxoids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D005467:Floxuridine; D000077143:Docetaxel; D017258:Medroxyprogesterone Acetate; D017239:Paclitaxel; C025034:doxifluridine