Gastrointestinal microflora studies in late-onset autism.
Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridium not found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found. In gastric and duodenal specimens, the most striking finding was total absence of non-spore-forming anaerobes and microaerophilic bacteria from control children and significant numbers of such bacteria from children with autism. These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder.
Finegold
Sydney M
SM
Infectious Diseases Section, Veterans Affairs Medical Center, West Los Angeles, CA, USA. sidfinegol@aol.com
Molitoris
Denise
D
Song
Yuli
Y
Liu
Chengxu
C
Vaisanen
Marja-Liisa
ML
Bolte
Ellen
E
McTeague
Maureen
M
Sandler
Richard
R
Wexler
Hannah
H
Marlowe
Elizabeth M
EM
Collins
Matthew D
MD
Lawson
Paul A
PA
Summanen
Paula
P
Baysallar
Mehmet
M
Tomzynski
Thomas J
TJ
Read
Erik
E
Johnson
Eric
E
Rolfe
Rial
R
Nasir
Palwasha
P
Shah
Haroun
H
Haake
David A
DA
Manning
Patricia
P
Kaul
Ajay
A
D017668:Age of Onset; D001321:Autistic Disorder / Q000382:microbiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003013:Clostridium / Q000145:classification / Q000302:isolation & purification*; D004064:Digestive System / Q000382:microbiology*; D006801:Humans