Adenomatous polyp recurrence and physical activity in the Polyp Prevention Trial (United States).
OBJECTIVE
To examine prospectively the association between physical activity and adenomatous polyp recurrence.


METHODS
Information on past year total physical activity was collected annually through an interview-administered questionnaire from the 1905 men and women enrolled in a randomized dietary intervention study, the Polyp Prevention Trial. Multiple logistic regression analysis was used to examine the association between physical activity and polyp recurrence in up to three years of follow-up from baseline colonoscopy.


RESULTS
There were no significant associations between moderate, vigorous, or total physical activity at the start of the trial and overall polyp recurrence in either men or women. Participants who reported consistent vigorous activity throughout the trial period had no significantly reduced risk of polyp recurrence compared to those who reported consistent sedentary activity (OR = 0.8, CI = 0.5-1.1). Consistent vigorous activity was also not significantly associated with either advanced or multiple polyps, nor with polyp recurrence at any specific anatomical location in the large bowel.


CONCLUSIONS
These prospective data suggest that recent physical activity is not associated with polyp recurrence in a three-year period.
Colbert
Lisa H
LH
National Institute on Aging, Bethesda, MD, USA. colbertl@mail.nih.gov
Lanza
Elaine
E
Ballard-Barbash
Rachael
R
Slattery
Martha L
ML
Tangrea
Joseph A
JA
Caan
Bette
B
Paskett
Electra D
ED
Iber
Frank
F
Kikendall
Walt
W
Lance
Peter
P
Shike
Moshe
M
Schoen
Robert E
RE
Daston
Cassandra
C
Schatzkin
Arthur
A
D018256:Adenomatous Polyps / Q000473:pathology*; D000368:Aged; D003110:Colonic Neoplasms / Q000473:pathology*; D003113:Colonoscopy; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010809:Physical Fitness; D011446:Prospective Studies; D012008:Recurrence; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors