title: In vitro susceptibility of 120 strains of Neisseria gonorrhoeae isolated in Kyrghyzstan.
abstract: BACKGROUND
  The World Health Organization has established a worldwide program for gonococcal antimicrobial surveillance, but so far no data on gonococcal susceptibility in Central Asia are available.
  
  
  OBJECTIVE
  The need for biological data on the susceptibility of Neisseria gonorrhoeae in Kyrghyzstan, to enable adaptation of the national treatment protocol for gonococcal infections, led Médecins Sans Frontières and Epicentre to conduct a survey in collaboration with the Alfred Fournier Institute in Paris and the health authorities in Bishkek.
  
  
  METHODS
  In vitro susceptibility of N gonorrhoeae strains was determined with use of the reference agar-plate dilution technique.
  
  
  RESULTS
  Results for 11 antibiotics tested on 120 strains of gonococci showed a low proportion (11.7%) of penicillinase-producing N gonorrhoeae and high proportions of intermediate or resistant strains to the majority of the antibiotics tested, including fluoroquinolones (>or=25% of strains resistant). All the strains were susceptible to spectinomycin, and only two strains had decreased susceptibility to cefixime.
  
  
  CONCLUSIONS
  The therapeutic choices available in Kyrghyzstan appear to be limited to cephalosporins and spectinomycin.
authors.affiliation: Epicentre, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Dorlencourt
authors.forename: C
authors.initials: C
authors.lastname: Boireaux
authors.forename: P
authors.initials: P
authors.lastname: Sednaoui
authors.forename: N V
authors.initials: NV
authors.lastname: Danilenko
authors.forename: D
authors.initials: D
authors.lastname: Legros
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001209:Asia, Central / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D006069:Gonorrhea / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents