A new trigger for T cells.
Understanding the early events in T cell activation and signaling is an active area of research. A recent study has described a new trigger for T cell activation, involving a TCR-ligand-induced conformational change in CD3epsilon that permits binding of the adaptor protein Nck.
Davis
Mark M
MM
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. mdavis@cmgm.stanford.edu
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017252:CD3 Complex; D002462:Cell Membrane / Q000276:immunology / Q000648:ultrastructure; D006801:Humans; D007107:Immune System / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D015513:Oncogene Proteins / Q000235:genetics / Q000276:immunology*; D011485:Protein Binding / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D017252:CD3 Complex; C115335:CD3E protein, human; C078332:Nck protein; D015513:Oncogene Proteins; D011948:Receptors, Antigen, T-Cell