title: [Properties of endoribonuclease activity of proteasomes from K562 cells. III. The specific endonuclease activity of ribonucleoprotein particles (alpha-RNP) tightly bound to chromatin and containing 20S proteosomes].
abstract: The present work demonstrates the ability of 20S proteasome-containing, tightly bound to chromatin RNP-particles (alpha-RNP) to endonucleolyse specific messenger RNAs (in particular, human mRNA for p53 gene and mRNA for luciferase from Renilla sp.). The dependence of individual mRNA endonucleolysis by alpha-RNP particles on both the substrate and enzyme was found.
authors.affiliation: Institute of Cytology RAS, St. Petersburg. agm@mail.cytspb.rssi.ru
authors.forename: A G
authors.initials: AG
authors.lastname: Mittenberg
authors.forename: V A
authors.initials: VA
authors.lastname: Kulichkova
authors.forename: L N
authors.initials: LN
authors.lastname: Gauze
authors.forename: I M
authors.initials: IM
authors.lastname: Konstantinova
mesh_terms: D002843:Chromatin / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000032:analysis / Q000378:metabolism*; D004722:Endoribonucleases / Q000378:metabolism*; D016158:Genes, p53; D006801:Humans; D020014:K562 Cells / Q000201:enzymology*; D008156:Luciferases / Q000235:genetics; D009097:Multienzyme Complexes / Q000032:analysis / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D012333:RNA, Messenger / Q000378:metabolism; D020736:Ribonucleoproteins, Small Cytoplasmic / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002843:Chromatin; D009097:Multienzyme Complexes; D012333:RNA, Messenger; D020736:Ribonucleoproteins, Small Cytoplasmic; D008156:Luciferases; D004722:Endoribonucleases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex