Effects of xenon on acetylcholine release in the rat cerebral cortex in vivo.
BACKGROUND
We have reported previously the effects of several anaesthetics on cholinergic activity in the central nervous system (CNS). In this study, we report the effects of xenon on cholinergic cell activity.


METHODS
Using in vivo brain microdialysis, we measured acetylcholine (ACh) release in the rat cerebral cortex in vivo during xenon anaesthesia.


RESULTS
Xenon induced an initial increase in ACh release, followed by a gradual decrease. The level of Ach release at 40 min of xenon administration was significantly higher than the control.


CONCLUSIONS
Xenon activates CNS cholinergic cell activity followed by development of acute tolerance.
Shichino
T
T
Department of Anesthesia, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Murakawa
M
M
Adachi
T
T
Miyazaki
Y
Y
Segawa
H
H
Fukuda
K
K
Mori
K
K
D000109:Acetylcholine / Q000378:metabolism*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D051381:Rats; D017208:Rats, Wistar; D014978:Xenon / Q000494:pharmacology*
D018685:Anesthetics, Inhalation; D014978:Xenon; D000109:Acetylcholine