Relationship between obsessive-compulsive disorder and chaos.
Pharmacological treatment using serotonin reuptake inhibitors is often useful for patients with obsessive-compulsive disorder (OCD). Brain imaging studies indicated that hyperactivity of the striatum observed in OCD patients is normalized after successful pharmacological treatment. But, so far, there is no available model, which can explain both of these phenomena. This report proposes a hypothesis that serotonin reuptake inhibitors can induce chaos in the activity of striatal neurons and this chaotic behavior is essential to improve OCD symptoms and normalize the hyperactivity in the striatum. Moreover, it can be explained also by this model that there exists a subtype of patients for whom pharmacological treatment is not useful. As a method, simulation using the Hodgkin-Huxley equations and the chaotic neural network, which can reproduce the chaotic behavior in the real neuron, are used.
Kubota
S
S
Mitsubishi Motors Corporation, Kanagawa, Japan.
Sakai
K
K
D003342:Corpus Striatum / Q000473:pathology; D006801:Humans; D017711:Nonlinear Dynamics; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012701:Serotonin / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors