[Effect of tumor necrosis factor alpha on the efficiency of anti-rabies vaccination].
Recombinant tumor necrosis factor-alpha (TNF-alpha) improved the survival of random-bred albino mice vaccinated with antirabies vaccine after infection with rabies CVS strain. The agent dose of 0.1 microgram/animal, injected 1 day postvaccination, was the most effective. Improvement of antiviral resistance of non-vaccinated mice under the effect of TNF-alpha suggests that the effect of this factor on nonspecific resistance factors is one of the probable mechanisms of its modulating effect.
Shestopalov
A M
AM
Rassadkin
Iu N
IuN
Ustinova
E N
EN
Danilenko
E D
ED
Belkina
A O
AO
Pustoshilova
N M
NM
Masycheva
V I
VI
D000818:Animals; D004347:Drug Interactions; D008297:Male; D051379:Mice; D011818:Rabies / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000008:administration & dosage; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*; D014611:Vaccination
D011819:Rabies Vaccines; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha