title: Protected indanones by a Heck-aldol annulation reaction.
abstract: Monoprotected 3-hydroxyindan-1-ones have been prepared in moderate to good yields by a new tandem reaction involving salicylaldehyde triflates and commercially available 2-hydroxyethyl vinyl ether. This one-pot annulation reaction proceeds in the presence of a palladium bidentate catalyst and results in the formation of two new ring systems.
authors.affiliation: Department of Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box-574, SE-751 23 Uppsala, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Bengtson
authors.forename: Mats
authors.initials: M
authors.lastname: Larhed
authors.forename: Anders
authors.initials: A
authors.lastname: Hallberg
mesh_terms: D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D008968:Molecular Conformation; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis*
chemical_list: D007189:Indans; D011480:Protease Inhibitors; C013352:indacrinone