Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure.
After an initial safety study in 7 normal volunteers, a randomized double-blind comparison was made between 3,5-diiodothyropropionic acid (DITPA) and placebo in 19 patients with moderately severe congestive failure. In heart failure patients receiving the drug for 4 weeks, cardiac index was increased (p = 0.04) and systemic vascular resistance index was decreased (p = 0.02). Systolic cardiac function was unchanged but isovolumetric relaxation time was decreased significantly, suggesting improvement in diastolic function. Total serum cholesterol (p = 0.005) and triglycerides (p = 0.01) also were decreased significantly. DITPA could represent a useful new agent for treatment of congestive heart failure.
Morkin
Eugene
E
Department of Cardiology, Southern Arizona Veterans Administration Health Care System and Sarver Heart Center, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA. emorkin@u.arizona.edu
Pennock
Gregory
G
Spooner
Peter H
PH
Bahl
Joseph J
JJ
Underhill Fox
Katherine
K
Goldman
Steven
S
D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D004104:Diiodothyronines / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011422:Propionates / Q000627:therapeutic use*; D013963:Thyroid Hormones / Q000097:blood / Q000627:therapeutic use*; D013972:Thyrotropin / Q000097:blood / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004104:Diiodothyronines; D011422:Propionates; D013963:Thyroid Hormones; C082182:3,5-diiodothyropropionic acid; D013972:Thyrotropin