Antiviral and cytotoxic activities of some Indonesian plants.
Ten methanolic extracts from eight Indonesian medicinal plants were phytochemically screened and evaluated for antiviral (HSV-1 and Poliovirus) and cytotoxic activities on murine and human cancer lines (3LL, L1210, K562, U251, DU145, MCF-7). Besides Melastoma malabathricum (Melastomataceae), the Indonesian Loranthaceae species among which Elytranthe tubaeflora, E. maingayi, E. globosa and Scurrula ferruginea exhibited attractive antiviral and cytotoxic activities. Piper aduncum (Piperaceae) was found active on Poliovirus. S. ferruginea was selected for further studies because of its activity on the U251 glioblastoma cells.
Lohézic-Le Dévéhat
F
F
Laboratoire de Pharmacognosie et de Mycologie, UPRES 2234, Avenue du Pr Léon Bernard, 35043, Rennes cedex, France. lohezic.francoise@libertysurf.fr
Bakhtiar
A
A
Bézivin
C
C
Amoros
M
M
Boustie
J
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D007214:Indonesia; D010946:Plants, Medicinal / Q000737:chemistry*; D017955:Poliovirus / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents