Modulation of GABA-activated currents in rat isolated cerebellar neurons by lanthanum ions.
Lanthanum ions (10-1000 microM) potentiated GABA-activated currents and increased the sensitivity of GABA(A) receptors in isolated Purkinje cells from rat cerebellum. GABA receptors in Purkinje cells are comparable to receptors on other cells by their sensitivity lanthanum ions.
Kolbaev
S N
SN
Institute of Brain Research, Russian Academy of Medical Sciences, Moscow. shar@cc.nifhi.ac.ru
D000818:Animals; D002412:Cations; D002531:Cerebellum / Q000166:cytology*; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D011689:Purkinje Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D002412:Cations; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D007811:Lanthanum