title: Alkaloids from Narcissus angustifolius subsp. transcarpathicus (Amaryllidaceae).
abstract: Seven alkaloids have been isolated from fresh bulbs of Narcissus angustifolius subsp. transcarpathicus (Amaryllidaceae). Nangustine, reported here for the first time, is the first 5,11-methanomorphanthridine alkaloid with a C-3/C-4 substitution. The structure and stereochemistry of this new alkaloid, as well as those previously known, have been determined by physical and spectroscopic methods. Spectroscopic data of pancracine have been completed. The in vitro assay activity against the parasitic protozoa Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani and Plasmodium falciparum was carried out with the compounds nangustine and pancracine.
authors.affiliation: Departament de Productes Naturals, Facultat de Farmàcia, Universitat de Barcelona, Avda. Diagonal 643, E-08028 Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Labraña
authors.forename: Alex King'ori
authors.initials: AK
authors.lastname: Machocho
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kricsfalusy
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Carles
authors.initials: C
authors.lastname: Codina
authors.forename: Francesc
authors.initials: F
authors.lastname: Viladomat
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D066298:In Vitro Techniques; D007893:Leishmania donovani / Q000187:drug effects; D015394:Molecular Structure; D031427:Narcissus / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013057:Spectrum Analysis; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000981:Antiprotozoal Agents