Favorable response to high-dose interferon-alpha in idiopathic hypereosinophilic syndrome with restrictive cardiomyopathy--case report and literature review.
The idiopathic hypereosinophilic syndrome is characterized by a prolonged overproduction of eosinophils of unknown cause in addition to specific organ damage due to eosinophil-derivated protein toxicity. Its prognosis is correlated with heart involvement that results in a restrictive cardiomyopathy. This is frequently biventricular. Isolated left ventricular infiltration has rarely been reported. The authors report a case of idiopathic hypereosinophilic syndrome with cardiac involvement obliterating the left ventricular cavity with a favorable clinical outcome following a combination therapy with interferon-alpha, hydroxyurea and prednisone. Data from other studies dealing with the treatment of idiopathic hypereosinophilic syndrome with interferon-alpha are reviewed and discussed.
Baratta
Luigi
L
Department of Medicina Clinica, La Sapienza University, Rome, Italy. Barattal@libero.it
Afeltra
Antonella
A
Delfino
Massimo
M
De Castro
Stefano
S
Giorgino
Flavia
F
Rossi-Fanelli
Filippo
F
D000328:Adult; D002313:Cardiomyopathy, Restrictive / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000188:drug therapy*; D007155:Immunologic Factors / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D012074:Remission Induction
D007155:Immunologic Factors; D016898:Interferon-alpha