title: Marine pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, anti-inflammatory, antiplatelet, antiprotozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action.
abstract: This review, a sequel to the 1998 review, classifies 63 peer-reviewed articles on the basis of the reported preclinical pharmacological properties of marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria. In all, 21 marine chemicals demonstrated anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antituberculosis or antiviral activities. An additional 23 compounds had significant effects on the cardiovascular, sympathomimetic or the nervous system, as well as possessed anti-inflammatory, immunosuppressant or fibrinolytic effects. Finally, 22 marine compounds were reported to act on a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. Thus, during 1999 pharmacological research with marine chemicals continued to contribute potentially novel chemical leads in the ongoing global search for therapeutic agents for the treatment of multiple disease categories.
authors.affiliation: Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA. amayer@midwestern.edu
authors.forename: Alejandro M S
authors.initials: AM
authors.lastname: Mayer
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D001685:Biological Factors / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002317:Cardiovascular Agents / Q000494:pharmacology / Q000627:therapeutic use; D002491:Central Nervous System Agents / Q000494:pharmacology / Q000627:therapeutic use; D004702:Endocrine Glands / Q000187:drug effects; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008386:Marine Biology; D010600:Pharmacology / Q000639:trends*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D001685:Biological Factors; D002317:Cardiovascular Agents; D002491:Central Nervous System Agents; D010975:Platelet Aggregation Inhibitors