[Subcutaneously implantable glucose sensors in patients with diabetes mellitus; still many problems].
Despite considerable scientific efforts, no clinical method is currently available for the continuous monitoring of glucose in subcutaneous tissue fluid. In general, good results were obtained during in-vitro experiments with various implantable glucose sensors. However, after implantation these devices exhibited a progressive loss of sensor function. It is evident that the tissue reaction to the implanted sensor, especially the interactions at the sensor-tissue interface, plays an important role in this loss of function. Adequate strategies to improve in-vivo sensor performance can only be developed if there is a better understanding of the processes involved in sensor inactivation.
Gerritsen
M
M
Tweesteden Ziekenhuis, afd. Interne Geneeskunde, Postbus 90.107, 5000 LA Tilburg.
Jansen
J A
JA
Lutterman
J A
JA
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000379:methods; D003920:Diabetes Mellitus / Q000097:blood*; D004867:Equipment Design; D004868:Equipment Failure; D006801:Humans; D008991:Monitoring, Physiologic; D019736:Prostheses and Implants; D012680:Sensitivity and Specificity
D001786:Blood Glucose