title: Dose-response stability and integrity of the dose distribution of various polymer gel dosimeters.
abstract: In this study the stability of different polymer gel dosimeters is investigated. Further to a previous chemical stability study on a (6%T, 50%C) PAG gel, the change in slope and intercept of the linear part of the R2-dose plot is recorded with time for different gel formulations. In addition to this R2-dose-response stability study, the dose edge of a half-blocked field was recorded with time. Three different PAG type polymer gels, a hydroxyethyl acrylate (HEA) gel and two different normoxic polymer gels were investigated. In the PAG type polymer gels, the relative concentration of gelatin and comonomers was varied in order to study the influence of the different components, that constitute the dosimeter, on the stability. It is shown that the R2-dose-response stability is largely determined by the chemical composition of the gel dosimeters. All the PAG gel dosimeters and the normoxic gel dosimeters are found to preserve the integrity of the dose distribution up to 22 days after irradiation. The half-life of the change in dose sensitivity of a MAGIC gel is found to be 18 h compared to 5.7 h for a (6%T, 50%C) PAG gel. A maximum relative decrease in dose sensitivity of 21% was noted for the MAGIC gel compared to an increase of 50% for a (6%T, 50%C) PAG gel. A loss of integrity of the dose distribution was found in the HEA gel.
authors.affiliation: Centre for Medical, Health and Environmental Physics, Queensland University of Technology, Brisbane, Australia. y.dedeene@qut.edu.au
authors.forename: Y
authors.initials: Y
authors.lastname: De Deene
authors.forename: A
authors.initials: A
authors.lastname: Venning
authors.forename: C
authors.initials: C
authors.lastname: Hurley
authors.forename: B J
authors.initials: BJ
authors.lastname: Healy
authors.forename: C
authors.initials: C
authors.lastname: Baldock
mesh_terms: D000180:Acrylic Resins / Q000145:classification / Q000528:radiation effects; D000447:Aldehydes; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D019544:Equipment Failure Analysis / Q000379:methods; D005782:Gels / Q000528:radiation effects*; D006207:Half-Life; D008422:Materials Testing / Q000379:methods*; D010315:Particle Accelerators; D011108:Polymers / Q000528:radiation effects*; D011134:Polysaccharides; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D000447:Aldehydes; D003037:Cobalt Radioisotopes; D005782:Gels; D011108:Polymers; D011134:Polysaccharides; C413302:poly(aldehyde guluronate); C016680:polyacrylamide gels