Chemotherapy of Chagas' disease: status and new developments.
Chagas' disease is a major parasitic problem in developing countries in Central and South America. Chemotherapy for such disease is still insufficient and not effective in its chronic part. Many efforts have been made in recent years to know more about possible new biochemical targets to design new selective drugs. This paper reviews old therapeutic approaches -Nifurtimox, Benznidazole and related compounds- and the latest rationally developed drugs that prove to be active against different parasitic forms.
Cerecetto
Hugo
H
Departamento de Qu mica Orgánica. Facultad de Química y Facultad de Ciencias, Universidad de la República. Avda. Gral. Flores 2124 CC 1157, Montevideo, 11800, Uruguay. hcerecet@bilbo.edu.uy
González
Mercedes
M
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D009547:Nifurtimox / Q000627:therapeutic use; D009593:Nitroimidazoles / Q000627:therapeutic use; D019764:Phosphoenolpyruvate Carboxykinase (ATP) / Q000037:antagonists & inhibitors; D019163:Reducing Agents / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000201:enzymology
D004791:Enzyme Inhibitors; D009593:Nitroimidazoles; D019163:Reducing Agents; D014344:Trypanocidal Agents; D019764:Phosphoenolpyruvate Carboxykinase (ATP); D009547:Nifurtimox; C009999:benzonidazole