[Genetics of lymphedema: from Milroy's disease to cancer investigations].
New insight has recently been obtained into the molecular mechanisms regulating lymphatic development and function during embryogenesis. VEGF-C and D ligands have been shown to stimulate lymphangiogenesis and their lymphatic-specific receptor VEGFR-3 is linked to the human congenital and hereditary lymphedema in humans. Above all, new focus on lymphatic endothelial cells gives opportunities for developing innovative therapies for lymphedema and cancer metastasis.
Quéré
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I
Service de médecine interne et maladies vasculaires, hôpital Saint-Eloi, 2, avenue Bertin-Sans, 34295 Montpellier, France. i-quere@chu-montpellier.fr
Coupé
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M
Soulier-Sotto
V
V
Evrard-Bras
M
M
Laroche
J P
JP
Janbon
C
C
D016228:Endothelial Growth Factors / Q000235:genetics* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008196:Lymph; D008209:Lymphedema / Q000235:genetics* / Q000503:physiopathology*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000150:complications; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D
D016228:Endothelial Growth Factors; D008024:Ligands; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D