title: Design of Protein Cores by Screening Combinatorial Sequence Library.
abstract: We have developed a new method, heterogeneous self-consistent ensemble optimization (hetero-SCEO), to select appropriate hydrophobic cores of proteins. It has been tested with five kinds of proteins: lambda-repressor, phage 434 CRO protein, interleukin-4, thioredoxin and ubiquitin. The results show that the method can be used for the de novo desigh of the hydrophobic cores of proteins.
authors.affiliation: Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. dingdafu@server.shcnc.ac.cn
authors.forename: Yu-Zhen
authors.initials: YZ
authors.lastname: Ye
authors.forename: Hai-Xu
authors.initials: HX
authors.lastname: Tang
authors.forename: Da-Fu
authors.initials: DF
authors.lastname: Ding