Genetic analysis of xanthogranulomatous cholecystitis: precancerous lesion of gallbladder cancer?
Xanthogranulomatous Cholecystitis is a chronic inflammatory disease of the gallbladder, a variant of the chronic cholecystitis. As xanthogranulomatous cholecystitis is occasionally seen with carcinoma of the gallbladder, the association with cancer is a controversial issue. A focal type of xanthogranulomatous cholecystitis is found simultaneously with gastric cancer diagnosed preoperatively. The resected specimen was genetically studied. Polymerase chain reaction amplification, single-strand conformational polymorphism analysis for mutation of p53 showed no abnormality indicating that less association with cancer in which the mutation of p53 is often seen. Etiopathologic factors of xanthogranulomatous cholecystitis might have relation with cancer, but xanthogranulomatous cholecystitis itself may not be the direct cause for cancer.
Takada
Moriatsu
M
Department of Surgery, Sanda City Hospital, 3-1-1, Keyaki-dai, Sanda, Hyogo, Japan.
Horita
Yoshiki
Y
Okuda
Saori
S
Okumoto
Satoru
S
Samizo
Masahiro
M
Wada
Takahiro
T
Kuroda
Yoshikazu
Y
Maeda
Sakan
S
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D002764:Cholecystitis / Q000235:genetics* / Q000473:pathology; D004252:DNA Mutational Analysis; D005091:Exons; D005704:Gallbladder / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000235:genetics* / Q000473:pathology; D006099:Granuloma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D014973:Xanthomatosis / Q000235:genetics* / Q000473:pathology
D016159:Tumor Suppressor Protein p53