title: HLA class II markers and clinical heterogeneity in Swedish patients with primary biliary cirrhosis.
abstract: Genetic susceptibility to PBC can, at least in part, be ascribed to the major histocompatibility complex. The relevance of immunogenetic markers for the clinical presentation and course, however, is unclear. Thus, the aim of this study was to investigate the contribution of HLA class II genes to susceptibility, clinical presentation and course of disease in PBC patients. HLA genotyping for HLA-DRB1, -DQB1 and -DPB1 was carried out in a total of 99 Swedish PBC patients and 158 controls. Clinical parameters including epidemiologic variables, signs and symptoms of PBC-related liver disease and histologic data were collected and analyzed in 92 patients at study entry and at follow-up five years later. Significant clinical heterogeneity was seen among PBC patients upon study entry. Although a significant disease association was seen for HLA DRB1*08 and DQB1*0402, immunogenetic markers identified neither a particular subset of patients nor an association with the clinical course of the disease. HLA-DRB1*08 and DQB1*0402 provide the strongest immunogenetic influence in PBC. However, this association is not restricted to any particular, clinically defined subgroup of patients and it is not predictive for the course of the disease.
authors.affiliation: 1Institute for Clinical Immunology, Department of Medicine III, University of Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Wassmuth
authors.forename: F
authors.initials: F
authors.lastname: Depner
authors.forename: A
authors.initials: A
authors.lastname: Danielsson
authors.forename: R
authors.initials: R
authors.lastname: Hultcrantz
authors.forename: L
authors.initials: L
authors.lastname: Lööf
authors.forename: R
authors.initials: R
authors.lastname: Olson
authors.forename: H
authors.initials: H
authors.lastname: Prytz
authors.forename: H
authors.initials: H
authors.lastname: Sandberg-Gertzen
authors.forename: S
authors.initials: S
authors.lastname: Wallerstedt
authors.forename: S
authors.initials: S
authors.lastname: Lindgren
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013548:Sweden
chemical_list: D000949:Histocompatibility Antigens Class II