Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3(-)CD4(+)CD45(+) inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.
Fukuyama
Satoshi
S
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Hiroi
Takachika
T
Yokota
Yoshifumi
Y
Rennert
Paul D
PD
Yanagita
Manabu
M
Kinoshita
Naotoshi
N
Terawaki
Seigo
S
Shikina
Takashi
T
Yamamoto
Masafumi
M
Kurono
Yuichi
Y
Kiyono
Hiroshi
H
D019264:Adoptive Transfer; D000818:Animals; D000831:Animals, Newborn; D000954:Antigens, Surface / Q000032:analysis / Q000502:physiology; D017252:CD3 Complex / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D051797:Inhibitor of Differentiation Protein 2; D019041:L-Selectin / Q000502:physiology; D017493:Leukocyte Common Antigens / Q000032:analysis; D008221:Lymphoid Tissue / Q000033:anatomy & histology / Q000254:growth & development*; D053259:Lymphotoxin beta Receptor; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018448:Models, Immunological; D009305:Nasopharynx / Q000033:anatomy & histology / Q000254:growth & development / Q000276:immunology*; D010581:Peyer's Patches / Q000033:anatomy & histology / Q000254:growth & development; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D020395:Receptors, Interleukin-7 / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D012097:Repressor Proteins; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D000097782:NF-kappaB-Inducing Kinase
D000954:Antigens, Surface; D017252:CD3 Complex; D004268:DNA-Binding Proteins; D051797:Inhibitor of Differentiation Protein 2; D019041:L-Selectin; D017493:Leukocyte Common Antigens; D053259:Lymphotoxin beta Receptor; D008565:Membrane Proteins; D017346:Protein Serine-Threonine Kinases; D020395:Receptors, Interleukin-7; D018124:Receptors, Tumor Necrosis Factor; D012097:Repressor Proteins; D014157:Transcription Factors; D000097782:NF-kappaB-Inducing Kinase; C497452:Idb2 protein, mouse; C069886:L-selectin counter-receptors; C505699:Ltbr protein, mouse