title: Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis.
abstract: To elucidate the mechanisms involved in the action of new macrolides on chronic sinusitis, we examined the effects of clarithromycin (CAM) and roxiythromycin (RXM) on the expression of adhesion molecules (L-selectin and Mac-1) on peripheral blood neutrophils of individuals with chronic sinusitis. The administration of CAM and RXM slightly inhibited the down-regulation of L-selectin expression on neutrophils induced by interleukin (IL)-8 stimulation. Furthermore, the administration of CAM strongly inhibited the IL-8-induced up-regulation of Mac-1 expression on neutrophils. These observations suggest that the new macrolides such as CAM and RXM may affect the functions of neutrophils in chronic sinusitis by modulating the expression of L-selectin and Mac-1 molecules on neutrophils, thereby attenuating the adhesion of neutrophils.
authors.affiliation: Department of Otorhinolaryngology, Junntendo University School of Medicine, 2-1-1 Hongou Bunkyou-ku, Tokyo 113-8421, Japan. fenomoto@med.juntendo.ac.jp
authors.forename: Fuyuki
authors.initials: F
authors.lastname: Enomoto
authors.forename: Ichirou
authors.initials: I
authors.lastname: Andou
authors.forename: Isao
authors.initials: I
authors.lastname: Nagaoka
authors.forename: Ginichirou
authors.initials: G
authors.lastname: Ichikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D017291:Clarithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000494:pharmacology; D019041:L-Selectin / Q000032:analysis*; D016177:Macrophage-1 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D015575:Roxithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D012852:Sinusitis / Q000188:drug therapy* / Q000276:immunology; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D016209:Interleukin-8; D016177:Macrophage-1 Antigen; D019041:L-Selectin; D015575:Roxithromycin; D017291:Clarithromycin