Adsorption of ligands on macromolecules in the fluctuating medium.
In the present work fluctuations of number of ligands adsorbed on macromolecule are investigated. We have taken into account the adsorption and desorption of ligands under the circumstance of some adsorption centers fluctuations affected by medium fluctuation. The correlation function and spectral density of number of ligands adsorbed on macromolecule are calculated. The properties of these fluctuations which allow identifying a noisemaker are determined. It has been shown, thatfas andsluggis adsorption can be distinguished by properties of dispersion and spectral density. It has been also shown, that comparison of experimental and theoretical correlation functions (or spectral densities) allows to calculate constants of ligand - adsorption center binding and unbinding.
Arakelyan
Valeri B
VB
Yerevan Physics Institute, Alikhanyan Br. Str. 2, Armenia.
Haroutiunian
Samvel G
SG
Arakelyan
Hakob V
HV
Haroutiunian
Tigran S
TS
D000327:Adsorption; D055592:Biophysical Phenomena; D001703:Biophysics; D008024:Ligands; D008962:Models, Theoretical; D011485:Protein Binding
D008024:Ligands