Modest gaze-related discharge modulation in monkey dorsal premotor cortex during a reaching task performed with free fixation.
Recent studies have shown that gaze angle modulates reach-related neural activity in many cortical areas, including the dorsal premotor cortex (PMd), when gaze direction is experimentally controlled by lengthy periods of imposed fixation. We looked for gaze-related modulation in PMd during the brief fixations that occur when a monkey is allowed to look around freely without experimentally imposed gaze control while performing a center-out delayed arm-reaching task. During the course of the instructed-delay period, we found significant effects of gaze angle in 27-51% of PMd cells. However, for 90-95% of cells, these effects accounted for <20% of the observed discharge variance. The effect of gaze was significantly weaker than the effect of reach-related variables. In particular, cell activity during the delay period was more strongly related to the intended movement expressed in arm-related coordinates than in gaze-related coordinates. Under the same experimental conditions, many cells in medial parietal cortex exhibited much stronger gaze-related modulation and expressed intended movement in gaze-related coordinates. In summary, gaze direction-related modulation of cell activity is indeed expressed in PMd during the brief fixations that occur in natural oculomotor behavior, but its overall effect on cell activity is modest.
Cisek
Paul
P
Centre de Recherche en Sciences Neurologiques, Université de Montréal, C.P. 6128, Succursale Centre-ville, Quebec H3C 3J7, Canada.
Kalaska
John F
JF
D000200:Action Potentials; D000818:Animals; D005133:Eye Movements; D008253:Macaca mulatta; D009043:Motor Activity; D009044:Motor Cortex / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology