title: [Mathematical model of trans-sarcomere exchange of calcium ions and Ca2+-dependent control of smooth muscle contractile activity].
abstract: The mathematical model of smooth muscles contractile activity Ca(2+)-dependent control has been proposed on the base of Ca ions trans-sarcomal exchange biochemical mechanisms interpretation in myocytes. While analysing the model the conclusion should be made that kinetic parameters changes (in relation to Ca ions) Mg2+, ATP-dependent calcium pump of plasma membrane--Michaelis constant Km and transport process maximal velocity Vmax-render the effect on the character of the intracellular calcium transients and profile of full mechanokinetic curve. As well one more conclusion has been made that plasma membrane Mg2+, ATP-dependent calcium pump, which kinetic parameters under the physiologic conditions are subjected to modulation as the result of metabolic, pharmacologic and physico-chemical factors fulfills the essential role in supplying Ca(2+)-dependent control of the smooth muscles contractile response full cycle.
authors.affiliation: Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
authors.forename: S O
authors.initials: SO
authors.lastname: Kosterin
authors.forename: M S
authors.initials: MS
authors.lastname: Miroshnychenko
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Pryluts'kyĭ
authors.forename: T L
authors.initials: TL
authors.lastname: Davydovs'ka
authors.forename: O V
authors.initials: OV
authors.lastname: Tsymbaliuk
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D009130:Muscle, Smooth / Q000378:metabolism*; D012518:Sarcomeres / Q000378:metabolism*
chemical_list: D000255:Adenosine Triphosphate; D002118:Calcium