Progress toward the total synthesis of ciguatoxins: a convergent synthesis of the FGHIJKLM ring fragment.
[structure: see text] A highly convergent synthetic route to the FGHIJKLM ring fragment of ciguatoxins has been developed, which relied on extensive use of the B-alkyl Suzuki-Miyaura coupling reaction.
Takakura
Hiroyuki
H
Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Japan.
Sasaki
Makoto
M
Honda
Shugo
S
Tachibana
Kazuo
K
D000595:Amino Acid Sequence; D002922:Ciguatoxins / Q000138:chemical synthesis* / Q000737:chemistry; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry
D010446:Peptide Fragments; D002922:Ciguatoxins