Lymphoma immunophenotyping: "borderline" lymphomas.
Immunophenotyping of B-cell lymphoproliferative disorders is indispensable, especially in disorders with CD19(+) CD5(+) B lymphocytes, where we have to make the distinction between low grade neoplasia, such as chronic lymphocytic leukemia with CD23(+) malignant lymphocytes, and aggressive neoplasia such as mantle cell lymphoma with CD23(-) malignant lymphocytes. We found some cases of CD19(+) CD5(+) lymphoproliferative disorders that do not meet all criteria for diagnosis of chronic lymphocytic leukemia or mantle cell lymphoma. For instance, we found cases with a low or no expression of CD23, asociated with absence of expression of FMC7 and surface immunoglobulins. These cases could be classified as "borderline" CD19(+) CD5(+) B cell lymphoproliferative disorders, with an intermediate neoplasic grade.
Mut-Popescu
Delia
D
Department of Hematology, "Coltea" Clinical Hospital, "Carol Davila" University of Medicine, 1, I.C. Bratianu Blvd., 70453 Bucharest, Romania. teammut@cmb.ro
Lupu
Anca
A
Bumbea
H.
H
Vladareanu
Ana-Maria
AM
Barbu
Doina
D
Angelescu
Silvana
S
Olteanu
Nicoleta
N
Colita
A.
A