title: Inv(4)(p14q27) in a case with de novo acute nonlymphocytic leukemia.
abstract: An inversion, inv(4)(p14q27), was found as the sole karyotypic anomaly at diagnosis in the bone marrow cells from a 65-year-old male patient with an M4 acute nonlymphocytic leukemia (ANLL). To our knowledge, the breakpoints observed in this case appear to be different from other inversions of chromosome 4 previously described in ANLL. The patient we described had a poor response to chemotherapy and had a short survival.
authors.affiliation: Centro de Estudios Genéticos (CEG), Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina, Buenos Aires, Argentina. ceg@ceg.com.ar
authors.forename: Silvia
authors.initials: S
authors.lastname: Benasayag
authors.forename: Eugenia
authors.initials: E
authors.lastname: Arias
authors.forename: Edgardo
authors.initials: E
authors.lastname: Baialardo
authors.forename: Myriam
authors.initials: M
authors.lastname: Reyes
authors.forename: Sandra
authors.initials: S
authors.lastname: Sapia
authors.forename: Alicia
authors.initials: A
authors.lastname: Bistmans
authors.forename: Irma
authors.initials: I
authors.lastname: Slavutsky
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D007446:Chromosome Inversion; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics / Q000648:ultrastructure*; D003561:Cytarabine / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage
chemical_list: D003561:Cytarabine; D008942:Mitoxantrone; D015255:Idarubicin