title: Troponins in experimental studies.
abstract: The aim of our study was to compare the diagnostic performance of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in three groups of rabbits: 1) control (saline 1 ml/kg i.v.); 2) daunorubicin (3 mg/kg i.v.); 3) daunorubicin (3 mg/kg i.v.) + dexrazoxane (60 mg/kg i.p.). The drugs were given once a week, 10 administrations. The concentration of cTnT was measured using Elecsys Troponin T STAT Immunoassay (Roche). The concentration of cTnI was measured using AxSYM Troponin I (Abbott). The linear regression model was applied to see if there is a dependence between cTnT and cTnI. The coefficient of determination (R2 = 0.79) was acceptable only in the control group. In the remaining cases (i.e. in the daunorubicin group and in the daunorubicin + dexrazoxane treated group) R2 was too small (0.53, and 0.06). We may conclude that in rabbits after repeated administration of cardiotoxic or cardioprotective drugs meaningful dependence between cTnT and cTnI was not found. The choice of the most suitable cardiomarker in laboratory animals deserves further studies.
authors.affiliation: Department of Physiology, Charles University, Prague, Faculty of Medicine. adamcova@lfhk.cuni.cz
authors.forename: Michaela
authors.initials: M
authors.lastname: Adamcová
authors.forename: Vladimír
authors.initials: V
authors.lastname: Gersl
authors.forename: Jarmila
authors.initials: J
authors.lastname: Machácková
authors.forename: Radomír
authors.initials: R
authors.lastname: Hrdina
authors.forename: Ivona
authors.initials: I
authors.lastname: Klimtová
authors.forename: Tomás
authors.initials: T
authors.lastname: Simůnek
authors.forename: Jaroslava
authors.initials: J
authors.lastname: Vávrová
authors.forename: Josef
authors.initials: J
authors.lastname: Bukac
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000175:diagnosis; D003630:Daunorubicin / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage; D011817:Rabbits; D011929:Razoxane / Q000008:administration & dosage; D020107:Troponin T / Q000097:blood*
chemical_list: D000903:Antibiotics, Antineoplastic; D015415:Biomarkers; D020011:Protective Agents; D020107:Troponin T; D011929:Razoxane; D003630:Daunorubicin