Intratympanic ciprofloxacin and the human labyrinthine sampling model.
OBJECTIVE
The aim of the study was to investigate the potential absorption of intratympanic ciprofloxacin through the human round window membrane.


METHODS
A prospective study.


METHODS
Ciprofloxacin was instilled into the middle ear of 10 patients undergoing acoustic tumor removal. The lateral semicircular canal and vestibule were subsequently opened and, using a microsyringe, labyrinthine fluid was aspirated. A sample each of serum and cerebrospinal fluid was also drawn.


RESULTS
Into each middle ear, 0.5 mL ciprofloxacin (0.3%) was instilled. The time interval between the ciprofloxacin application to the round window membrane and sampling of labyrinthine fluid and plasma ranged from 9 to 120 minutes. There was no measurable ciprofloxacin in the labyrinthine fluid, cerebrospinal fluid, or serum of 10 patients.


CONCLUSIONS
The lack of measurable absorption of intratympanic ciprofloxacin into the inner ear indicates that the chance of ototoxicity when ciprofloxacin is used clinically, even in the presence of a tympanic membrane perforation, is low.
Becvarovski
Zoran
Z
Michigan Ear Institute, Farmington Hills, USA. zb@ent.com.au
Kartush
Jack M
JM
Bojrab
Dennis I
DI
D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007758:Ear, Inner / Q000378:metabolism; D005260:Female; D006801:Humans; D007761:Labyrinthine Fluids / Q000737:chemistry; D008297:Male; D011446:Prospective Studies; D012405:Round Window, Ear; D014432:Tympanic Membrane
D000890:Anti-Infective Agents; D002939:Ciprofloxacin