[Anti-atherosclerotic action of mildronate in experiment].
Mildronate is a new antiischemic drug which inhibits biosynthesis of carnitine from butyrobetaine. We studied antiatherosclerotic and antiinflammatory effects of mildronate in guinea-pigs, rats and rabbits. We found a hypolipidemic action of this substance in rats with triton WR-1339 hyperlipidemia. A protective antiatherosclerotic effect of mildronate was observed in rabbits kept on the atherogenic diet for 3 months. Antiinflammatory efficiency of mildronate in rats was demonstrated after injection of bradykinin, carragenine or implantation of a small cotton-wool pad.
Okunevich
I V
IV
Ryzhenkov
V E
VE
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D001161:Arteriosclerosis / Q000188:drug therapy*; D001920:Bradykinin; D002317:Cardiovascular Agents / Q000494:pharmacology* / Q000633:toxicity; D006168:Guinea Pigs; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007928:Lethal Dose 50; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008763:Methylhydrazines / Q000494:pharmacology* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000633:toxicity; D011817:Rabbits; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002317:Cardiovascular Agents; D008055:Lipids; D008763:Methylhydrazines; D011092:Polyethylene Glycols; C050147:3-(2,2,2-trimethylhydrazine)propionate; D001920:Bradykinin; C016811:tyloxapol