IL-6 and lipoprotein(a) [LP(a)] concentrations are related only in patients with high APO(a) isoforms in monoclonal gammopathy.
We have investigated the influence of apo(a) genetics on the relationship between interleukin (IL)-6, and lipoprotein (a) [Lp(a)] levels in 154 patients with monoclonal gammopathy and 189 healthy subjects. No significant differences in Lp(a) levels and distribution of subjects with different sizes of apo(a) isoforms were found between patients and healthy controls. Relationship between IL-6 and Lp(a) levels was strongly dependent on the size of apo(a) isoforms. In patients with high-size apo(a) isoforms Lp(a) levels positively correlated (r=0.475, P=0.0007) to IL-6 concentrations, whereas no correlation was found in patients with low apo(a) isoforms. Our present finding may provide a plausible explanation for the contradictory findings about the acute phase protein nature of Lp(a).
Horváth
Laura
L
3rd Department of Medicine, Faculty of Medicine, Semmelweis University Budapest, Hungary.
Császár
Albert
A
Falus
András
A
Dieplinger
Hans
H
Horváth
Anna
A
Puskás
Eva
E
Halm
Gabriella
G
Bányai
Anikó
A
Pálóczi
Katalin
K
László
Elöd
E
Kalabay
László
L
Romics
László
L
Füst
George
G
D000328:Adult; D000368:Aged; D001054:Apolipoproteins A / Q000096:biosynthesis* / Q000737:chemistry*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D017270:Lipoprotein(a) / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism; D010265:Paraproteinemias / Q000378:metabolism*; D011110:Polymorphism, Genetic; D020033:Protein Isoforms; D008258:Waldenstrom Macroglobulinemia / Q000378:metabolism
D001054:Apolipoproteins A; D015850:Interleukin-6; D017270:Lipoprotein(a); D020033:Protein Isoforms