title: Time trends in organ position and volume in patients receiving prostate three-dimensional conformal radiotherapy.
abstract: Using multiple computed tomography (CT) scans, 50 patients undergoing prostate radiotherapy were tested for clinically significant time trends in the target and surrounding critical structures. Significant trends were observed toward increasing bladder volume and increasing bowel-to-planning target volume separation; however, no trends were observed in the prostate, seminal vesicles, or rectum. The subset of patients undergoing hormone therapy was also tested and did not independently exhibit any significant time trends.
authors.affiliation: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Mechalakos
authors.forename: Gikas S
authors.initials: GS
authors.lastname: Mageras
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zelefsky
authors.forename: Olga
authors.initials: O
authors.lastname: Lyass
authors.forename: Marcel
authors.initials: M
authors.lastname: van Herk
authors.forename: Hanne M
authors.initials: HM
authors.lastname: Kooy
authors.forename: Steven A
authors.initials: SA
authors.lastname: Leibel
authors.forename: C Clifton
authors.initials: CC
authors.lastname: Ling
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D020360:Neoadjuvant Therapy; D016684:Prone Position; D011467:Prostate / Q000033:anatomy & histology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D020266:Radiotherapy, Conformal; D013995:Time; D014057:Tomography, X-Ray Computed; D001743:Urinary Bladder / Q000033:anatomy & histology
chemical_list: D000726:Androgen Antagonists