title: Analysis of tau haplotypes in Pick's disease.
abstract: Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.
authors.affiliation: Neurogenetics, Institute of Neurology, Reta Lila Weston Institute of Neurological Research, University College London, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: Baker
authors.forename: K
authors.initials: K
authors.lastname: Yasojima
authors.forename: H
authors.initials: H
authors.lastname: Houlden
authors.forename: M N
authors.initials: MN
authors.lastname: Khan
authors.forename: N W
authors.initials: NW
authors.lastname: Wood
authors.forename: J
authors.initials: J
authors.lastname: Hardy
authors.forename: M
authors.initials: M
authors.lastname: Grossman
authors.forename: J
authors.initials: J
authors.lastname: Trojanowski
authors.forename: T
authors.initials: T
authors.lastname: Revesz
authors.forename: E H
authors.initials: EH
authors.lastname: Bigio
authors.forename: C
authors.initials: C
authors.lastname: Bergeron
authors.forename: J C
authors.initials: JC
authors.lastname: Janssen
authors.forename: P L
authors.initials: PL
authors.lastname: McGeer
authors.forename: M N
authors.initials: MN
authors.lastname: Rossor
authors.forename: A J
authors.initials: AJ
authors.lastname: Lees
authors.forename: P L
authors.initials: PL
authors.lastname: Lantos
authors.forename: M
authors.initials: M
authors.lastname: Hutton
mesh_terms: D000368:Aged; D000483:Alleles; D001921:Brain / Q000473:pathology; D016009:Chi-Square Distribution; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020774:Pick Disease of the Brain / Q000235:genetics* / Q000473:pathology; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins