Dancing with the host; flow-dependent bacterial adhesion.
Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flow of blood over endothelium or mucous over the surface of the epithelium.
Isberg
Ralph R
RR
Howard Hughes Medical Institute, Boston, MA 02111, USA. ralph.isberg@tufts.edu
Barnes
Penelope
P
D018829:Adhesins, Bacterial / Q000378:metabolism*; D018830:Adhesins, Escherichia coli; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D036781:Fimbriae Proteins; D010861:Fimbriae, Bacterial / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology; D012212:Rheology
D018829:Adhesins, Bacterial; D018830:Adhesins, Escherichia coli; D011956:Receptors, Cell Surface; C058769:fimH protein, E coli; D036781:Fimbriae Proteins