Sirenomelia sequence: first-trimester diagnosis with both two- and three-dimensional sonography.
OBJECTIVE
To describe the sonographic findings of sirenomelia during the first trimester on both two-dimensional sonography with color Doppler imaging and three-dimensional sonography.


METHODS
Two cases of sirenomelia in primiparous patients with histories of infertility are described. The diagnosis was made on the basis of two-dimensional sonography, and three-dimensional sonography was used to further characterize the findings.


RESULTS
Both fetuses had size-date discrepancies, increased nuchal translucency, large intra-abdominal vessels, and 2-vessel umbilical cords. Both pregnancies were terminated by dilation and curettage after the patients viewed the three-dimensional pictures of the fetuses.


CONCLUSIONS
During the first trimester of pregnancy, rare and lethal anomalies can be diagnosed with a high degree of confidence if a thorough, age-dependent anatomic survey of the fetus is performed.
Monteagudo
Ana
A
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, USA.
Mayberry
Patricia
P
Rebarber
Andrei
A
Paidas
Michael
M
Timor-Tritsch
Ilan E
IE
D000025:Abortion, Eugenic; D000328:Adult; D004480:Ectromelia / Q000000981:diagnostic imaging*; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal