[Nasolacrimal ducts and the dry eye].
BACKGROUND
The knowledge regarding the pathogenesis, diagnosis, and treatment of dry eye has made large advances in recent years. However, many questions are still unanswered. Although the nasolacrimal ducts are part of the tear system they have been paid nearly no attention regarding dry eye.


METHODS
The present knowledge about the nasolacrimal ducts is presented and discussed in a context with dry eye. A PubMED search was conducted for articles published from 1966 to the present; in addition, review articles as well as book chapters were considered and discussions with investigators in the field were performed.


RESULTS
As a draining and secretory system, the nasolacrimal ducts play a role in tear transport and non-specific immune defense. Moreover, components of tear fluid are absorbed in the nasolacrimal passage and are transported into a vascular system that surrounds the nasolacrimal sac and nasolacrimal duct. This system is comparable to a cavernous body and it is connected to the blood vessels of the outer eye. Also it is subject to vegetative control. Organized mucosa-associated lymphoid tissue (MALT) is present in the nasolacrimal ducts displaying the cytomorphological and immunophenotypic features of MALT.


CONCLUSIONS
The normally constant absorption of tear fluid components into the blood vessels of the surrounding cavernous body that are connected to the blood vessels of the outer eye, could be a feedback signal for tear fluid production, which comes to a halt if these tear components are not absorbed. Thus, dry eye could be initiated. Defective stimulation of tear duct-associated lymphoid tissue (TALT) could result in abnormal immune deviation at the ocular surface leading to an autoimmunological response that causes dry eye pathology.
Paulsen
F
F
Anatomisches Institut, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, 24098 Kiel.
Thale
A
A
Schaudig
U
U
D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015352:Dry Eye Syndromes / Q000276:immunology* / Q000473:pathology; D005246:Feedback / Q000502:physiology; D006801:Humans; D008208:Lymphatic System / Q000276:immunology* / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D009301:Nasolacrimal Duct / Q000276:immunology* / Q000473:pathology; D017634:Self Tolerance / Q000276:immunology; D013666:Tears / Q000276:immunology