Inflammatory reaction and alterations of pulmonary surfactant in Pseudomonas Aeruginosa pneumonia in immunocompromised rats.
Pulmonary surfactant ( PS ) compromises lipids and surfactant proteins (SP) and lines on the alveolar air-liquid interface. It can reduce surface tension, prevent alveoli from collapse and reduce alveoli edema by disaturated dipalmitoylphosphatidylcholine. It also modulates the pulmonary immunology by SP-A and SP-D. In this study,we established a rat model of immunocompromised host (ICH) with pulmonary infection of Pseudomonas aeruginosa (P. aeruginosa), then studied its pulmonary inflammatory reaction and analyzed the concentration of lipids and SP-A in bronchoalveolar lavage fluid (BALF) during infection.
Qu
Jieming
J
Department of Pulmonary Medicine, Zhongshan Hospital, Institute of Respiratory Diseases, Fudan University, Shanghai 200032, China. jiemingc@online.sh.cn
Li
Zhuozhe
Z
He
Lixian
L
Sun
Bo
B
Chen
Xuehua
X
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000382:microbiology; D008055:Lipids / Q000032:analysis; D008168:Lung / Q000382:microbiology; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000378:metabolism; D011510:Proteolipids / Q000032:analysis*; D011552:Pseudomonas Infections / Q000276:immunology* / Q000378:metabolism; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008055:Lipids; D011510:Proteolipids; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants