Chemokines, their receptors, and transplant outcome.
Organ transplant rejection is mediated largely by circulating peripheral leukocytes induced to infiltrate the graft by various inflammatory stimuli. Of these, chemotactic cytokines called chemokines, expressed by inflamed graft tissues, as well as by early innate-responding leukocytes that infiltrate the graft, are responsible for the recruitment of alloreactive leukocytes. This report discusses the impact of these leukocyte-directing proteins on transplant outcome and novel therapeutic approaches for antirejection therapy based on targeting of chemokines and/or their receptors.
Colvin
Bridget L
BL
Thomas E. Starzl Transplantation Institute and Departments of Surgery, Molecular Genetics and Biochemistry, and Inmunology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Thomson
Angus W
AW
D000818:Animals; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D019707:Receptors, Chemokine / Q000502:physiology*; D014184:Transplantation, Homologous / Q000276:immunology
D018925:Chemokines; D019707:Receptors, Chemokine