Cotylenin A--a plant growth regulator as a differentiation-inducing agent against myeloid leukemia.
Acute myeloid leukemia (AML) is characterized by the arrest of differentiation leading to the accumulation of immature cells. This maturation arrest can be reversed by certain agents. Although differentiation therapy for patients with acute promyelocytic leukemia (APL) using all-trans retinoic acid (ATRA) has been established, the clinical response of AML patients other than those with APL to ATRA is limited. We must consider novel therapeutic drugs against other forms of AML for the development of a differentiation therapy for leukemia. Regulators that play an important role in the differentiation and development of plants or invertebrates may also affect the differentiation of human leukemia cells through a common signal transduction system, and might be clinically useful for treating AML. Cotylenin A, a plant growth regulator, is a potent and novel inducer of the monocytic differentiation of human myeloid leukemia cell lines and leukemia cells freshly isolated from AML patients.
Honma
Yoshio
Y
Saitama Cancer Center Research Institute, Ina, Japan. honma@cancer-c.pref.saitama.jp
D000818:Animals; D000943:Antigens, Differentiation / Q000096:biosynthesis; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects*; D002762:Cholecalciferol / Q000627:therapeutic use; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D018922:HL-60 Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000473:pathology; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology; D012176:Retinoids / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014212:Tretinoin / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000943:Antigens, Differentiation; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D012176:Retinoids; C423222:cotylenin A; D002762:Cholecalciferol; D014212:Tretinoin