[Dependence of mode of DNA binding to benzo crown derivatives of actinocin on the size and distance from the chromophore of crown fragments].
Complexes of DNA with benzocrown derivatives of actinocin were studied by viscometry and dynamic birefringence. Changes in the macromolecular structure of DNA caused by complex formation were determined. Models of DNA binding to the studied compounds were suggested on the basis of data obtained. The intercalation of actinocin chromophore of benzocrown derivatives of actinocin was shown to occur only when benzocrown groups were bound to the chromophore via glycine fragment. A change in the distance between the crown group and the chromophore prevents ligand intercalation. Increase in medium ionic strength results in appearance of new nonintercalational binding mode for crown-containing compounds with DNA caused by interaction of the crown groups with DNA.
Moroshkina
E B
EB
St. Petersburg State University, St. Petersburg, 198904 Russia. evmorosh@mail.ru
Zagoruĭko
N E
NE
Ovchinnikov
D V
DV
Plekhanova
N G
NG
Glibin
E N
EN
D000409:Alanine / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D005998:Glycine / Q000737:chemistry; D008024:Ligands; D009994:Osmolar Concentration; D010078:Oxazines / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014783:Viscosity
D008024:Ligands; D010078:Oxazines; C006401:actinocin; D004247:DNA; D000409:Alanine; D005998:Glycine