title: Resin dynamics contributes to the NMR line broadening of organic molecules grafted onto a polystyrene resin.
abstract: Despite the use of high resolution magic angle spinning NMR, the NMR linewidth of anchored molecules on the commonly used Merrifield solid phase resins remains larger than that of the corresponding molecules in solution. We investigate the different mechanisms that might be at the origin of this line broadening. Experimentally, we use the CPMG method to determine the (15)N relaxation times of a tethered tripeptide and show that the slow resin dynamics significantly contributes to the transverse relaxation.
authors.affiliation: CNRS, Université de Lille 2 UMR 8525, Institut Pasteur de Lille and Institut de Biologie de Lille, 1 rue du Professeur Calmette, BP447, 59019 Lille Cedex, France.
authors.forename: Guy
authors.initials: G
authors.lastname: Lippens
authors.forename: Gianni
authors.initials: G
authors.lastname: Chessari
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Wieruszeski
mesh_terms: D016880:Anisotropy; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D015394:Molecular Structure; D010455:Peptides / Q000378:metabolism*; D011137:Polystyrenes / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*
chemical_list: D010455:Peptides; D011137:Polystyrenes; D012116:Resins, Plant