title: New hydrogen donor: a facile method for the removal of hydrogenolysable protecting groups in Peptide synthesis.
abstract: Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and 10%Pd on carbon is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. This is more effective than hydrazine or formic acid.
authors.affiliation: Department of Studies in Chemistry, University of Mysore, Manasagangotri, Karnataka, India. dcgowda@yahoo.com
authors.forename: D Channe
authors.initials: DC
authors.lastname: Gowda
authors.forename: B
authors.initials: B
authors.lastname: Mahesh
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D005561:Formates / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D006859:Hydrogen; D007854:Lead / Q000737:chemistry*; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry
chemical_list: D000596:Amino Acids; D005561:Formates; D006834:Hydrazines; D010455:Peptides; C030544:formic acid; C007969:hydrazinium; C029424:hydrazine; D007854:Lead; D002244:Carbon; D006859:Hydrogen