title: Enhanced sensitisation of mice with diphtheria tetanus acellular pertussis vaccine to local swelling reaction to the booster immunisation.
abstract: Severe local swelling has been regarded as a serious safety problem for the booster immunisations of diphtheria tetanus acellular pertussis combined (DTaP) vaccine and DT combined toxoids (DT-td). We attempted to search for the factor of DTaP vaccines possibly contributing to the enhanced local reaction by using the mouse hind paw swelling reaction. Mice were immunised intramuscularly with DTaP vaccine twice at 1-month interval and were challenged their hind paw with one of the antigens of DTaP vaccine 2 weeks later. D-td was shown to elicit the strongest swelling among the vaccine antigens. No causal relationship was found between the swelling and the level of immunoglobulin G (IgG) or IgE in mice. Residual pertussis toxin (PT) activity of DTaP vaccines for immunisation was shown to play a role in the enhanced sensitisation of mice to the D-td-related hind paw swelling.
authors.affiliation: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan. yama-aki@nih.go.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Noriyo
authors.initials: N
authors.lastname: Nagata
authors.forename: Masaki
authors.initials: M
authors.lastname: Ochiai
authors.forename: Michiyo
authors.initials: M
authors.lastname: Kataoka
authors.forename: Hiromi
authors.initials: H
authors.lastname: Toyoizumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Okada
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Horiuchi
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D004167:Diphtheria Toxin / Q000276:immunology / Q000633:toxicity*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology / Q000633:toxicity*; D004487:Edema / Q000209:etiology*; D005260:Female; D007114:Immunization; D007117:Immunization, Secondary / Q000009:adverse effects*; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007213:Indomethacin / Q000494:pharmacology; D007273:Injections, Intramuscular; D051379:Mice; D008807:Mice, Inbred BALB C; D037342:Pertussis Toxin / Q000276:immunology / Q000633:toxicity*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004167:Diphtheria Toxin; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D037342:Pertussis Toxin; D007213:Indomethacin