title: [Chronic bronchial dilatations in different colonies of laboratory rats].
abstract: Bronchiectasis occurred naturally in 12-month-old spontaneously diabetic eSS male rats. The lungs of 3 and 6-month-old eSS rats were compared in eumetabolic eSS rats from three inbred lines consisting of inbred spontaneously diabetic eSS derived from IIM strain; these were compared with eumetabolic, outbred Wistar rats, paired by sex and age. Acrylic casts of bronchial tree were obtained after injection of a plastic substance. The casts were pruned to focus on the first four bronchial branchings. Diameter and volume of the conductive bronchial tree were determined using a binocular magnifier. Histological sections were obtained. All lines showed multiple bronchiectasis, mostly fusiform, bronchial dilatation and inflammatory response with lymphocytic infiltrates. These symptoms were much more severe in 180-day-old eSS males. Bacteria were isolated from the lungs in 70% of cases (n = 32), except in eSS rats. Pseudomonas spp. (38%) and Gram-positive cocci as coagulase-negative Staphylococcus spp. (20%) were detected. Neither pathogenic bacteria nor saprophyte fungi were found. Although all lines were affected, diabetes in eSS appears to be an aggravating factor.
authors.affiliation: Museo de Anatomía Normal, Facultad de Ciencias Médicas, Rosario, Argentina.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Miguel
authors.forename: Ariana
authors.initials: A
authors.lastname: Erazo
authors.forename: Fernanda
authors.initials: F
authors.lastname: Beduino
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Picena
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Luciano
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pizzutti
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Tarrés
authors.forename: Silvana
authors.initials: S
authors.lastname: Montenegro
authors.forename: Stella Maris
authors.initials: SM
authors.lastname: Martínez
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001987:Bronchiectasis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D011549:Pseudomonas / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013210:Staphylococcus / Q000302:isolation & purification