Surveillance in Barrett's oesophagus: a personal view.
Barrett's oesophagus is defined as columnar-lined oesophagus of any length containing specialised intestinal metaplasia. Diagnosis depends on close corroboration between the endoscopist and histopathologist. It occurs in 10% of patients presenting endoscopically with reflux symptoms and has an adenocarcinoma incidence of 0.4% to 2%. Surveillance is performed to detect precancerous change (dysplasia) and early stage disease has a good surgical prognosis. Computer models suggest cost efficacy comparable to other health measures. However most patients with Barrett's do not die of oesophageal cancer and elective oesophagectomy has an appreciable mortality. Endoscopic ablation techniques and improved definition of high risk subgroups will help shape future surveillance programmes.
Basu
K K
KK
Department of Integrated Medicine, Glenfield Hospital, Leicester, UK. kumarbasu@netscapeonline.co.uk
de Caestecker
J S
JS
D000230:Adenocarcinoma / Q000175:diagnosis*; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000628:therapy; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D006801:Humans; D011159:Population Surveillance / Q000379:methods*; D011230:Precancerous Conditions / Q000175:diagnosis*; D012307:Risk Factors