title: Plant development: regulation by protein degradation.
abstract: Many aspects of eukaryotic development depend on regulated protein degradation by the ubiquitin-proteasome pathway. This highly conserved pathway promotes covalent attachment of ubiquitin to protein substrates through the sequential action of three enzymes called a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin-protein ligase (E3). Most ubiquitinated proteins are then targeted for degradation by the 26S proteasome. Recent studies have also shown that the ubiquitin-related protein RUB/Nedd8 and the proteasome-related COP9 signalosome complex cooperate with the ubiquitin-proteasome pathway to promote protein degradation. Most of these components are conserved in all three eukaryotic kingdoms. However, the known targets of the pathway in plants, and the developmental processes they regulate, are specific to the plant kingdom.
authors.affiliation: Molecular Cell and Developmental Biology, University of Texas, Austin, TX 78712, USA.
authors.forename: Hanjo
authors.initials: H
authors.lastname: Hellmann
authors.forename: Mark
authors.initials: M
authors.lastname: Estelle
mesh_terms: D000075686:COP9 Signalosome Complex; D007210:Indoleacetic Acids / Q000494:pharmacology; D008027:Light; D009024:Morphogenesis / Q000187:drug effects; D046912:Multiprotein Complexes; D010447:Peptide Hydrolases / Q000378:metabolism*; D063245:Plant Development; D018521:Plant Physiological Phenomena / Q000187:drug effects; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000378:metabolism; D025801:Ubiquitin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007210:Indoleacetic Acids; D046912:Multiprotein Complexes; D010940:Plant Proteins; D011506:Proteins; D025801:Ubiquitin; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease