title: Psychiatric and substance use disorders as risk factors for low birth weight and preterm delivery.
abstract: OBJECTIVE
  We examined the associations between psychiatric and substance use diagnoses and low birth weight (LBW), very low birth weight (VLBW), and preterm delivery among all women delivering in California hospitals during 1995.
  
  
  METHODS
  This population-based retrospective cohort analysis used linked hospital discharge and birth certificate data for 521,490 deliveries. Logistic regression analyses were conducted to assess the associations between maternal psychiatric and substance use hospital discharge diagnoses and LBW, VLBW, and preterm delivery while controlling for maternal demographic and medical characteristics.
  
  
  RESULTS
  Women with psychiatric diagnoses had a significantly higher risk of LBW (adjusted odds ratio [OR] 2.0; 95% confidence interval [CI] 1.7, 2.3), VLBW (OR 2.9; 95% CI 2.1, 3.9), and preterm delivery (OR 1.6; 95% CI 1.4, 1.9) compared with women without those diagnoses. Substance use diagnoses were also associated with higher risk of LBW (OR 3.7; 95% CI 3.4, 4.0), VLBW (OR 2.8; 95% CI 2.3, 3.3), and preterm delivery (OR 2.4; 95% CI 2.3, 2.6).
  
  
  CONCLUSIONS
  Maternal psychiatric and substance use diagnoses were independently associated with low birth weight and preterm delivery in the population of women delivering in California in 1995. Identifying pregnant women with current psychiatric disorders and increased monitoring for preterm and low birth weight delivery among this population may be indicated.
authors.affiliation: Department of Psychiatry, University of Washington, Seattle, Washington 98195, USA. rhkelly@u.washington.edu
authors.forename: Rosemary H
authors.initials: RH
authors.lastname: Kelly
authors.forename: Joan
authors.initials: J
authors.lastname: Russo
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Holt
authors.forename: Beate H
authors.initials: BH
authors.lastname: Danielsen
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Zatzick
authors.forename: Edward
authors.initials: E
authors.lastname: Walker
authors.forename: Wayne
authors.initials: W
authors.lastname: Katon
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D016015:Logistic Models; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D007752:Obstetric Labor, Premature / Q000453:epidemiology*; D016017:Odds Ratio; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*