title: Hemorrhage and VEGF expression in a case of primary CNS lymphoma.
abstract: Hemorrhage at presentation in primary CNS lymphoma is exceedingly rare. We describe a patient with primary CNS lymphoma who presented with seizures and was found to have an intracerebral hemorrhage which prompted a cerebral angiogram. Ultimately pathologic evaluation of the lesion revealed a highly cellular B-cell lymphoma with marked hypervascularity and intense expression of vascular endothelial growth factor (VEGF). A review of four other recent cases of primary CNS lymphoma at our institution revealed less-intense VEGF immunoreactivity. This is the first report of VEGF expression in primary CNS lymphoma. The potential significance of VEGF expression with respect to the biology of this tumor is discussed.
authors.affiliation: Division of Hematology/Oncology, University of California, San Francisco 94143, USA. jamesr@medicine.ucsf.edu
authors.forename: James
authors.initials: J
authors.lastname: Rubenstein
authors.forename: Nancy
authors.initials: N
authors.lastname: Fischbein
authors.forename: Ken
authors.initials: K
authors.lastname: Aldape
authors.forename: Eric
authors.initials: E
authors.lastname: Burton
authors.forename: Marc
authors.initials: M
authors.lastname: Shuman
mesh_terms: D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology*; D016228:Endothelial Growth Factors / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors