Radiosensitivity in Fanconi's anemia patients.
The risks of radiation therapy in patients with Fanconi's anemia who have cancer are not clear. Possible toxicity was reported in six of 14 patients: 1/1 with vaginal cancer, 4/10 with head and neck or esophageal cancer, and 1/3 with oral cancer following bone marrow transplant.
Alter
Blanche P
BP
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7020, Rockville, MD 20852, USA.
D000293:Adolescent; D000328:Adult; D002648:Child; D004938:Esophageal Neoplasms / Q000150:complications / Q000532:radiotherapy*; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000175:diagnosis; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000150:complications / Q000532:radiotherapy*