Absorption of calcium fumarate salts is equivalent to other calcium salts when measured in the rat model.
Calcium absorption from fumarate salts (calcium fumarate and calcium malate fumarate), which have recently been considered for use as sources for food and beverage enrichment, was compared to that from calcium citrate malate, calcium citrate, and calcium carbonate. Salts were instrinsically labeled with 45Ca and orally administered to Sprague-Dawley rats. Fractional absorption of calcium from each salt was determined using the femur uptake model. Fractional absorption from the five salts (0.30-0.27) was not significantly different (p > 0.05). Thus, when measured in the rat model, calcium from calcium fumarate and calcium malate fumarate is absorbed equally well as compared to other salts, which are common calcium sources in many foods, beverages, and supplements.
Weaver
Connie M
CM
Department of Foods and Nutrition, Purdue University, 1264 Stone Hall, West Lafayette, Indiana 47907-1264, USA.
Martin
Berdine R
BR
Costa
Neuza M B
NM
Saleeb
Fouad Z
FZ
Huth
Peter J
PJ
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D002118:Calcium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002132:Calcium Radioisotopes; D019587:Dietary Supplements; D005650:Fumarates / Q000493:pharmacokinetics*; D008293:Malates / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002132:Calcium Radioisotopes; D005650:Fumarates; D008293:Malates; D002118:Calcium