Synthesis, structure, and DNA cleavage activity of new trinuclear Zn(3) and Zn(2)Cu complexes of a chiral macrocycle: structural correlation with the active center of P1 nuclease.
New homo trinuclear Zn(II) complexes [Zn(3)L(1)(micro-OAc)](ClO(4))(2).3CHCl(3).H(2)O, 1, and [Zn(3)L(1)(micro-OAc)].ClO(4).PF(6).5CH(3)OH.H(2)O, 2, and hetero trinuclear complex [Zn(2)CuL(1)(micro-OAc)](ClO(4))(2).3CHCl(3).H(2)O,3, of optically active hexaaza triphenolic macrocycle H(3)L(1) were synthesized and crystallographically characterized. The cation [Zn(3)L(1)(micro-OAc)](+) structure of 1 and 2 closely resembles the trinuclear Zn(II) active site of P1 nuclease. The distorted tetrahedral geometry of Zn3 was successfully reproduced at Cu1 in complex 3. The complexes 2 and 3 cleave CT DNA at 37 and 50 degrees C.
Korupoju
Srinivas R
SR
School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
Mangayarkarasi
Nagarathinam
N
Zacharias
Panthapally S
PS
Mizuthani
Jun
J
Nishihara
Hiroshi
H
D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000187:drug effects*; D008956:Models, Chemical; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D009942:Organometallic Compounds; D003300:Copper; D004247:DNA; D015719:Single-Strand Specific DNA and RNA Endonucleases; D015032:Zinc