title: The vaccinia virus I7L gene product is the core protein proteinase.
abstract: Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.
authors.affiliation: Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Chelsea M
authors.initials: CM
authors.lastname: Byrd
authors.forename: Tove' C
authors.initials: TC
authors.lastname: Bolken
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Hruby
mesh_terms: D000818:Animals; D002460:Cell Line; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D005816:Genetic Complementation Test; D016297:Mutagenesis, Site-Directed; D011498:Protein Precursors / Q000378:metabolism; D014162:Transfection; D014616:Vaccinia virus / Q000201:enzymology* / Q000235:genetics; D014758:Viral Core Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D011498:Protein Precursors; D014758:Viral Core Proteins; C080700:protein I7, vaccinia virus; D003546:Cysteine Endopeptidases