Do small heat shock proteins protect skeletal muscle from injury?
Prior exercise training protects skeletal muscle from contraction-induced injury. However, the mechanisms of protection are unknown. In this paper, the hypothesis is developed that exercise-induced increases in small heat shock protein activity may protect muscle cells via interactions with cytoskeletal elements and/or the glutathione system.
Koh
Timothy J
TJ
School of Kinesiology, University of Illinois, Chicago 60608, USA. tjkoh@uic.edu
D000818:Animals; D019610:Cytoprotection / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005978:Glutathione / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000293:injuries / Q000378:metabolism / Q000502:physiology*; D014481:United States; D014947:Wounds and Injuries / Q000517:prevention & control*
D006360:Heat-Shock Proteins; D005978:Glutathione