A mitochondrial Achilles' heel in cancer?
Mitochondria are principal actors in apoptosis as central hubs for diverse apoptotic signals. A new paper demonstrates the therapeutic potential of directly engaging these apoptotic pathways by identifying a mitochondrial toxin selective for tumor cells.
Hockenbery
David M
DM
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. dhockenb@fhcrc.rog
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D007211:Indoles / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000187:drug effects; D011726:Pyridinium Compounds / Q000378:metabolism* / Q000494:pharmacology; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D007211:Indoles; D024101:Mitochondrial Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011726:Pyridinium Compounds; C471842:4-(2-(indol-3-yl)vinyl)-1-methylpyridinium