title: Phytotherapy for benign prostatic hyperplasia.
abstract: Phytotherapy has become a more popular treatment option among American men with benign prostatic hyperplasia (BPH). The most popular herbal agent is saw palmetto (Serenoa repens), which is derived from the berry of the American dwarf palm tree. Pygeum africanum and beta-sitosterol are also used by many patients with BPH, either alone or in combination with saw palmetto. A significant limiting factor to our understanding of the use and effectiveness of phytotherapy is the lack of standardization of these products. Despite this lack of standardization and the variation in results that may be seen with herbal products, there is growing evidence from well-conducted clinical trials that phytotherapeutic agents may lead to subjective and objective symptom improvement beyond a placebo effect in men with BPH. In addition, histologic evidence has been presented demonstrating that saw palmetto causes atrophy and epithelial contraction within the prostate gland. Overall, it is likely that herbal therapy will continue to be used by a growing number of Americans to treat a variety of ailments. Physicians should attempt to remain open-minded regarding alternative approaches and educate themselves so that they may counsel patients in an informed and credible fashion.
authors.affiliation: Section of Urology, University of Chicago, 5841 S. Maryland Avenue, MC 6038, Chicago, IL 60637, USA. ggerber@surgery.bsd.uchicago.edu
authors.forename: Glenn S
authors.initials: GS
authors.lastname: Gerber
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011058:Pollen / Q000737:chemistry; D011467:Prostate / Q000187:drug effects / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D027861:Prunus / Q000737:chemistry; D028024:Serenoa; D012855:Sitosterols / Q000494:pharmacology / Q000627:therapeutic use; D014563:Urodynamics / Q000187:drug effects
chemical_list: D000726:Androgen Antagonists; D010936:Plant Extracts; D012855:Sitosterols; C025473:gamma-sitosterol; C040972:saw palmetto extract