[Genetic polymorphisms, function and clinical effect of HLA-G].
HLA-G is a non-classical major histocompatibility complex class I molecule that differs from the classical HLA I class molecules by (1) a limited polymorphism, (2) a tissue-restricted distribution and (3) a transcription of spliced messenger RNAs encoding for at least four membrane-bound and two soluble HLA-G isoforms. Extensive studies over the past few years have identified HLA-G as a molecule involved in immune tolerance. In this review, attempts were made to summarize the current state of knowledge of the polymorphisms, expression, function, the effects of HLA-G on immuno-associated disease, evolution of HLA-G and its utility in disease therapy.
Meng
Haiying
H
School of Forensic and Pre-clinical Medicine, Sichuan University, Chengdu, Sichuan, 610041 P.R.China. forensic@mail.sc.cninfo.net
Hou
Yiping
Y
D000483:Alleles; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D011110:Polymorphism, Genetic; D013602:T-Lymphocytes, Cytotoxic; D014327:Trophoblasts / Q000276:immunology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I