Rapamycin blocks the generation of regulatory T cells facilitated by posttransplant infusion of donor T cells through increasing the apoptosis of thymic CD4(+)CD25(+) cells.
Tsui
Tung-Yu
TY
Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road 102, Hong Kong, China.
Lau
C-K
CK
Schlitt
H J
HJ
Fan
S-T
ST
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D015704:CD4 Antigens / Q000276:immunology*; D007165:Immunosuppression Therapy / Q000379:methods; D017710:Lymphocyte Transfusion; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D020123:Sirolimus / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D015704:CD4 Antigens; D015375:Receptors, Interleukin-2; D020123:Sirolimus