title: The Ran GTPase: theme and variations.
abstract: The small GTPase Ran has roles in multiple cellular processes, including nuclear transport, mitotic spindle assembly, the regulation of cell cycle progression and nuclear assembly. The past year has seen a remarkable unification of these different roles with respect to the effectors and mechanisms through which they function. Our emergent understanding of Ran suggests that it plays a central role in spatial and temporal organization of the vertebrate cell.
authors.affiliation: Laboratory of Gene Regulation and Development, NICHD/NIH, Bethesda, MD 20892-5431, USA. mdasso@helix.nih.gov
authors.forename: Mary
authors.initials: M
authors.lastname: Dasso
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D008941:Spindle Apparatus; D020931:ran GTP-Binding Protein / Q000378:metabolism* / Q000502:physiology
chemical_list: D020931:ran GTP-Binding Protein