MHC restriction in contact hypersensitivity to dicyclohexylcarbodiimide.
Mouse ear swelling tests were performed using different strains of mice with dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), di-p-tolylcarbodiimide (DTC), and positive control chemicals, such as dinitrochlorobenzene (DNCB) and oxazolone (OXA). The chemicals were examined at different doses up to the minimal irritating concentration determined in a irritancy assay. While BALB/c mice exhibited strong responses for the carbodiimide compounds, C3H/HeN mice demonstrated no reactions. Other strains, C57BL/6 and DBA/1, also showed responses to DCC, but CBA/J mice with the same haplotype as C3H/HeN (H-2(k)) did not. Based on our present findings, there may be a specific unresponsiveness to DCC dependent on the H-2(k) haplotype.
Kato
H
H
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 3-1-98 Kasugadenaka Konohana-ku, Osaka 554-8558, Japan. katoh5@sc.sumimoto-chem.co.jp
Hayashi
M
M
Fukumori
Y
Y
Kaneko
H
H
D000818:Animals; D017951:Antigen Presentation; D002234:Carbodiimides / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000276:immunology*; D004024:Dicyclohexylcarbodiimide / Q000276:immunology / Q000633:toxicity*; D004423:Ear; D006183:H-2 Antigens; D006239:Haplotypes; D006241:Haptens / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA
D002234:Carbodiimides; D006183:H-2 Antigens; D006241:Haptens; D004024:Dicyclohexylcarbodiimide