title: Endogenous regulation of the acute inflammatory response.
abstract: The acute inflammatory response has been triggered in rat lungs by deposition of IgG immune complexes. The inflammatory reaction triggered is highly tissue damaging and requires activation of NF-kappaB with ensuing generation of chemokines and cytokines. Endogenous generation of IL- 10 and IL- 13 as well as secretory leukocyte protease inhibitor (SLPI), significantly regulates this inflammatory response. IL-10 and IL-13 attenuate NF-kappaB activation by interfering with breakdown of IkappaBalpha, while SLPI likewise suppresses NF-kappaB activation, but by interfering with breakdown of IkappaBbeta. Antibody induced blockade of IL-10, IL-13 or SLPI enhances NF-KB activation in lung and exacerbates the lung inflammatory response and injury. These data indicate that endogenous IL-10, IL-13 and SLPI are important regulators of the inflammatory response by reducing gene activation with resultant generation of peptide mediators/cytokines and chemokines.
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor 48109, USA. pward@umich.edu
authors.forename: Peter A
authors.initials: PA
authors.lastname: Ward
authors.forename: Alex B
authors.initials: AB
authors.lastname: Lentsch
mesh_terms: D000208:Acute Disease; D000818:Animals; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology*; D016753:Interleukin-10 / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D008168:Lung / Q000378:metabolism / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000378:metabolism; D051381:Rats; D053481:Secretory Leukocyte Peptidase Inhibitor
chemical_list: D018793:Interleukin-13; D016328:NF-kappa B; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D053481:Secretory Leukocyte Peptidase Inhibitor; C506816:Slpi protein, rat; D016753:Interleukin-10