[The role of specific endothelial granules in changes of myocardium microvessel reperfusion at open-heart operations under hypothermia].
For patients with congenital heart defects, a comparative analysis was carried out of specific endothelial granules and morphological properties of perfusion capacity of microvessels at various stages of reperfusion after prolonged circulatory arrest. At all stages of reperfusion, the quantity of specific granules in microvessel endothelium dramatically dropped, as compared with the control group. At the early stages of reperfusion, the level of granule exocytosis does not lead to any statistically significant changes in perfusion characteristics in the right atrium microvessels, as compared with the control group. Conversely, at the late stages of reperfusion, degranulation of endothelial cells is enhanced, and physiological mechanisms intended to remove the microvessels from circulation are replaced with pathological ones. These results suggest the existence of a threshold in exocytosis of specific endothelial granules, whose exceeding may switch on some pathological mechanisms in blood flow regulation.
Kazanskaia
G M
GM
Research Institute of Circulation Pathology, Ministry of Public Health, Russian Federation, Novosibirsk.
Volkov
A M
AM
Chasovskikh
G G
GG
D'iakonitsa
T M
TM
Gorbatykh
Iu N
IuN
D015550:Cell Degranulation; D003331:Coronary Vessels / Q000503:physiopathology* / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000502:physiology / Q000648:ultrastructure; D006321:Heart / Q000503:physiopathology*; D006324:Heart Arrest, Induced; D006325:Heart Atria; D006330:Heart Defects, Congenital / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007036:Hypothermia, Induced; D008833:Microcirculation / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000648:ultrastructure; D022142:Secretory Vesicles / Q000502:physiology / Q000648:ultrastructure