title: Experimental substantiation of the possibility of developing selenium- and iodine-containing pharmaceuticals based on blue-green algae Spirulina platensis.
abstract: The great potential of using blue-green algae Spirulina platensis as a matrix for the production of selenium- and iodine-containing pharmaceuticals is shown experimentally. The background levels of 31 major, minor and trace elements (Na, Mg, Al, Cl, K, Ca, Sc, V, Cr, Mn, Fe, Co, Ni (using (n,p) reaction), As, Br, Zn, Rb, Mo, Ag, Sb, I, Ba, Sm, Tb, Tm, Hf, Ta, W, Au, Hg, Th) in S. platensis biomass were determined by means of epithermal neutron activation analysis. The dependence of selenium and iodine accumulation in spirulina biomass on a nutrient medium loading of the above elements was characterized. To demonstrate the possibilities of determining toxic element intake by spirulina biomass, mercury was selected. The technological parameters for production of iodinated treatment-and-prophylactic pills are developed.
authors.affiliation: EL Andronikashvili Institute of Physics, Georgian Academy of Sciences, Tamarashvili str 6, 380077, Tbilisi, Georgia.
authors.forename: L M
authors.initials: LM
authors.lastname: Mosulishvili
authors.forename: E I
authors.initials: EI
authors.lastname: Kirkesali
authors.forename: A I
authors.initials: AI
authors.lastname: Belokobylsky
authors.forename: A I
authors.initials: AI
authors.lastname: Khizanishvili
authors.forename: M V
authors.initials: MV
authors.lastname: Frontasyeva
authors.forename: S S
authors.initials: SS
authors.lastname: Pavlov
authors.forename: S F
authors.initials: SF
authors.lastname: Gundorina
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis*; D018533:Biomass; D002138:Calibration; D000458:Cyanobacteria / Q000737:chemistry* / Q000254:growth & development; D007455:Iodine / Q000737:chemistry*; D019216:Metals, Heavy / Q000032:analysis; D009501:Neutron Activation Analysis; D011786:Quality Control; D012643:Selenium / Q000737:chemistry*; D053545:Spirulina; D013607:Tablets; D014131:Trace Elements / Q000032:analysis
chemical_list: D001426:Bacterial Proteins; D019216:Metals, Heavy; D013607:Tablets; D014131:Trace Elements; D007455:Iodine; D012643:Selenium