Effects of chronic specific urogenital infections on contractility of the human isolated pregnant myometrium.
The contractile activity of the isolated myometrium of pregnant women with mycoplasma, chlamydia and mixed infections has been studied by pharmacological organ bath method. We found that mycoplasma infection decreased while chlamydia or mixed infection increased myometrium contraction evoked by oxytocin or prostaglandin F2alpha. The results of this study could be important for the prediction of possible complications during pregnancy and labour in women with chronic specific urogenital infections.
Zefirova
Julia T
JT
Department of Pharmacology, Kazan State Medical University, Russia.
Zefirova
Tatiana P
TP
Ziganshina
Lilia E
LE
Ziganshin
Airat U
AU
D002690:Chlamydia Infections / Q000382:microbiology / Q000503:physiopathology*; D002908:Chronic Disease; D015237:Dinoprost / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D009175:Mycoplasma Infections / Q000382:microbiology / Q000503:physiopathology*; D009215:Myometrium / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology*; D009924:Organ Culture Techniques; D010121:Oxytocin / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000503:physiopathology*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects / Q000276:immunology*
D010121:Oxytocin; D011189:Potassium Chloride; D006632:Histamine; D015237:Dinoprost