Neonatal mydriasis: intravenous lidocaine adverse reaction.
Lidocaine (a sodium channel blocker) serves as an antiepilepsy drug in neonates. We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose. We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.
Berger
Itai
I
Neuro-Pediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel. itberg@szmc.org.il
Steinberg
Avraham
A
Schlesinger
Yechtiel
Y
Seelenfreund
Mordechai
M
Schimmel
Michael S
MS
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D062787:Drug Overdose; D004359:Drug Therapy, Combination; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D015878:Mydriasis / Q000139:chemically induced* / Q000175:diagnosis*; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D010672:Phenytoin; D008012:Lidocaine; D010634:Phenobarbital