title: Morphologic and morphometric analyses of acetic acid-induced colitis in rats after treatment with enemas from Myracrodruon urundeuva Fr. All. (Aroeira do Sertão).
abstract: The present work showed the effects of Myracrodruon urundeuva Fr. All., popularly known as 'aroeira' (AE), in the form of enemas prepared from the stem bark, on several morphologic and morphometric parameters after acetic acid-induced colitis in rats. Enemas from 5-ASA were used as standard while the vehicle, carboxymethylcellulose, was used as a control. The results of the morphological evaluation showed that on day 1 acetic acid produced significantly more necrosis in the groups treated with AE (10% and 20%) or 5-ASA than the controls. However, on day 60, there were more caliciform and absorptive cells in the treated groups compared with the controls. A significantly higher number of eosinophil and mononuclear cells and also collagen deposition in the controls compared with the treated groups were observed on day 60. However, a higher number of polymorphonuclear cells was detected on day 60 only in the AE treated group but not in the 5-ASA group. These data indicate that animals treated with AE or 5-ASA showed complete epithelial tissue regeneration, while in the controls chronic inflammatory exudate persisted and tissue regeneration occurred through fibrosis.
authors.affiliation: Department of Surgery, Federal University of Ceará, Fortaleza, Brazil.
authors.forename: Lusmar Veras
authors.initials: LV
authors.lastname: Rodrigues
authors.forename: Francisco Valdeci
authors.initials: FV
authors.lastname: Ferreira
authors.forename: F Sérgio P
authors.initials: FS
authors.lastname: Regadas
authors.forename: Délcio
authors.initials: D
authors.lastname: Matos
authors.forename: Glauce Socorro de Barros
authors.initials: GS
authors.lastname: Viana
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D027926:Anacardiaceae; D000818:Animals; D001938:Brazil; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000166:cytology / Q000187:drug effects; D004733:Enema / Q000379:methods*; D004804:Eosinophils / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009336:Necrosis; D009504:Neutrophils / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D003094:Collagen; D019342:Acetic Acid