title: Endogenous endophthalmitis following disseminated fungemia due to Fusarium solani in a patient with acute myeloid leukemia.
abstract: We report the case of a young man with a resistant acute myeloid leukemia (AML) who developed a disseminated fungemia due to Fusarium solani involving the skin and lungs, during the neutropenic phase following a chemotherapy course. Despite continuous therapy with liposomal amphotericin B, he developed a bilateral endophthalmitis that rapidly evolved to complete blindness. The patient underwent two procedures of vitrectomy, with detection of F. solani in the vitreous fluid, and continued antifungal therapy, without any recovery of visual acuity. When he eventually died due to recurrence of leukemia and hemorrhagic shock, autopsy revealed a diffuse fusarial involvement of the central nervous system.
authors.affiliation: Division of Hematology, University of Udine, Ospedale Santa Maria della Misericordia, I-13300 Udine, Italy. ematologia@dmm.uniud.it
authors.forename: Mario
authors.initials: M
authors.lastname: Tiribelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Zaja
authors.forename: Carla
authors.initials: C
authors.lastname: Filì
authors.forename: Teresa
authors.initials: T
authors.lastname: Michelutti
authors.forename: Simonetta
authors.initials: S
authors.lastname: Prosdocimo
authors.forename: Anna
authors.initials: A
authors.lastname: Candoni
authors.forename: Renato
authors.initials: R
authors.lastname: Fanin
mesh_terms: D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000633:toxicity; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology*; D017809:Fatal Outcome; D016469:Fungemia / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D005670:Fusarium; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009181:Mycoses