Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge.
The Drosophila gene wingless encodes a secreted signalling molecule that is required for many patterning events in both embryonic and postembryonic development. In the wing wingless is expressed in a complex and dynamic pattern that is controlled by several different mechanisms. These involve the Hedgehog and Notch pathways and the nuclear proteins Pannier and U-shaped. In this report, we analyse the mechanisms that drive wingless expression in the wing hinge. We present evidence that wingless is initially activated by a secreted signal that requires the genes vestigial, rotund and nubbin. Later in development, wingless expression in the wing hinge is maintained by a different mechanism, which involves an autoregulatory loop and requires the genes homothorax and rotund. We discuss the role of wingless in patterning the wing hinge.
Rodríguez Dd
David del Alamo
Ddel A
Centro de Biología Molecular-Severo Ochoa/C.S.I.C., Facultad de Ciencias-CV, Universidad Autónoma-Cantoblanco, 28049 Madrid, Spain.
Terriente
Javier
J
Galindo
Máximo I
MI
Couso
Juan Pablo
JP
Díaz-Benjumea
Fernando J
FJ
D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D007814:Larva; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D050809:POU Domain Factors; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014921:Wings, Animal / Q000196:embryology / Q000378:metabolism*; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D050809:POU Domain Factors; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D051155:Wnt1 Protein; C108704:hth protein, Drosophila; C104121:nub protein, Drosophila; C450829:rn protein, Drosophila; C095064:vg protein, Drosophila; C074622:wg protein, Drosophila