title: Laryngeal collagen injection as an adjunct to medialization laryngoplasty.
abstract: OBJECTIVE
  Dysphonia associated with laryngeal paralysis may be identified in the short term postoperatively or may develop years after successful medialization laryngoplasty. In selected cases, laryngeal collagen injection permits further medialization of one or both vocal folds by small increments to improve phonation after medialization thyroplasty. The study seeks to determine whether collagen injections result in measurable improvements in voice quality and vocal function when offered to select patients who have received medialization thyroplasty.
  
  
  METHODS
  Retrospective review of patient charts and voice database.
  
  
  METHODS
  Seven patients were treated with Zyderm II collagen using indirect mirror laryngoscopy and a curved injection apparatus. Changes in voice quality and function were assessed by comparing measures obtained before treatment (mean period, 5.6 d), shortly after treatment (mean period, 38.1 d), and in the long term after treatment (mean period, 226 d).
  
  
  RESULTS
  Mean self-ratings of the patient, clinician's ratings, and objective measures demonstrated measurable improvement in vocal function after collagen injection.
  
  
  CONCLUSIONS
  The office-based procedure offers a simple, efficient adjunct to open techniques of medialization laryngoplasty. Techniques of anesthesia, injection, and patient selection are discussed.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
authors.forename: Henry
authors.initials: H
authors.lastname: Hoffman
authors.forename: Daniel
authors.initials: D
authors.lastname: McCabe
authors.forename: Timothy
authors.initials: T
authors.lastname: McCulloch
authors.forename: Sung M
authors.initials: SM
authors.lastname: Jin
authors.forename: Michael
authors.initials: M
authors.lastname: Karnell
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007267:Injections; D007830:Larynx; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014826:Vocal Cord Paralysis / Q000628:therapy*; D014833:Voice Quality
chemical_list: D003094:Collagen