title: ACE gene polymorphism and renal scar in children with acute pyelonephritis.
abstract: The pathogenesis of renal scarring after acute pyelonephritis (APN) in children is multifactorial. In addition to well-known risk factors (young age, high grade of vesicoureteral reflux, P-fimbriated Escherichia coli, and treatment delay), a role for genetic predisposition has been suggested. Since the ACE gene deletion polymorphism is a known risk factor for progressive glomerulosclerosis in chronic renal diseases, we have investigated the relationship between the ACE genotypes and the development of renal scarring after APN. Fifty-nine children (43 males and 16 females) with APN diagnosed by urine culture and technetium-99m-dimercaptosuccinic acid ((99)Tc-DMSA) renal scan were studied. ACE genotypes were determined as II, ID, and DD using the polymerase chain reaction technique. A follow-up (99)Tc-DMSA renal scan was performed to evaluate the development of renal scars 3-6 months after treatment. The distribution of ACE genotypes and the allele frequencies were compared in the renal scar-positive ( n=39) and -negative group ( n=20). ACE genotype frequency after stratification by risk factors was also evaluated. The distribution of ACE genotypes did not differ between the renal scar-positive (II 25.9%, ID 35.9%, DD 28.2%) and -negative group (II 35.0%, ID 45.0%, DD 20.0%), before and after stratification by each risk factor. ACE gene deletion polymorphism did not affect the development of renal scar as an independent variable in children with APN.
authors.affiliation: Department of Pediatrics, Division of Nephrology, Medical Research Center, Ewha Woman's University Mokdong Hospital, 911-1 MokDong, YangChoen-Ku, Seoul, Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Cho
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D002921:Cicatrix / Q000473:pathology; D004927:Escherichia coli Infections / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011704:Pyelonephritis / Q000235:genetics* / Q000473:pathology*; D014552:Urinary Tract Infections / Q000473:pathology; D014718:Vesico-Ureteral Reflux / Q000235:genetics / Q000382:microbiology / Q000473:pathology
chemical_list: D007703:Peptidyl-Dipeptidase A