title: A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection.
authors.affiliation: Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA.
authors.forename: W
authors.initials: W
authors.lastname: Waegell
authors.forename: M
authors.initials: M
authors.lastname: Babineau
authors.forename: M
authors.initials: M
authors.lastname: Hart
authors.forename: K
authors.initials: K
authors.lastname: Dixon
authors.forename: B
authors.initials: B
authors.lastname: McRae
authors.forename: C
authors.initials: C
authors.lastname: Wallace
authors.forename: M
authors.initials: M
authors.lastname: Leach
authors.forename: S
authors.initials: S
authors.lastname: Ratnofsky
authors.forename: A
authors.initials: A
authors.lastname: Belanger
authors.forename: G
authors.initials: G
authors.lastname: Hirst
authors.forename: A
authors.initials: A
authors.lastname: Rossini
authors.forename: M
authors.initials: M
authors.lastname: Appel
authors.forename: J
authors.initials: J
authors.lastname: Mordes
authors.forename: D
authors.initials: D
authors.lastname: Greiner
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016207:Cytokines / Q000096:biosynthesis; D003921:Diabetes Mellitus, Experimental / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016038:Skin Transplantation / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D016207:Cytokines; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)