title: Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine.
abstract: The synthesis and characterization of new coordination compounds of some diorganotins(IV) with N-methylglycine (sarcosine) are reported; all these derivatives mainly tend to assume a chelate structure. As single crystals were not obtained, a large number of experimental techniques were used to accomplish a definitive characterization and determination of their structure. Results obtained by (1)H/(119)Sn NMR, FT-IR and (119)mSn-Mössbauer spectroscopy and thermogravimetric analysis allow us to deduce the pentacoordination for 1:1 (Sn/sarcosine) derivatives [R(2)SnCl(2)(Sar)](+)Cl(-) (R=Me, n-Bu) in a trigonal-bipyramidal structure, and the hexacoordination for 1:2 complexes [R'(2)Sn(Sar)(2)](2+)2Cl(-) (R'=Me, n-Bu, Ph) in an octahedral structure; however, the probability of partially or totally non-chelate structures for some adducts increases with the steric hindrance of the R/R' groups and the number of the sarcosine molecules bound to the tin atom, so that they give rise to fluxional equilibria in solution. Finally, the synthesized compounds have been tested for in vitro cytotoxic activity against human adenocarcinoma HeLa cells showing, in some cases, strong activity even at low concentration.
authors.affiliation: Dipartimento di Chimica Inorganica, Metallorganica ed Analitica dell'Università, via Loredan 4, 35131, Padova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ronconi
authors.forename: C
authors.initials: C
authors.lastname: Marzano
authors.forename: U
authors.initials: U
authors.lastname: Russo
authors.forename: S
authors.initials: S
authors.lastname: Sitran
authors.forename: R
authors.initials: R
authors.lastname: Graziani
authors.forename: D
authors.initials: D
authors.lastname: Fregona
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012521:Sarcosine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis; D013818:Thermogravimetry
chemical_list: D000970:Antineoplastic Agents; D009947:Organotin Compounds; D012521:Sarcosine