The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat.
Glucocorticoid receptor activation inhibits granule cell proliferation in the hippocampus, but little is known about the role of mineralocorticoid receptors in this process. Here we administered aldosterone to adrenalectomized (ADX) rats, and monitored neurogenesis by BrdU immunohistochemistry. ADX significantly increased the number of BrdU-positive cells and aldosterone replacement further augmented BrdU-positivity. Our results indicate that aldosterone, most probably acting through mineralocorticoid receptors, may positively influence the proliferation and survival of newly-generated granule cells.
Fischer
Anja K
AK
Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
von Rosenstiel
Philipp
P
Fuchs
Eberhard
E
Goula
Daniel
D
Almeida
Osborne F X
OF
Czéh
Boldizsár
B
D000315:Adrenalectomy; D000450:Aldosterone / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D018891:Dentate Gyrus / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018161:Receptors, Mineralocorticoid / Q000187:drug effects / Q000378:metabolism
D018161:Receptors, Mineralocorticoid; D000450:Aldosterone