Novel intracellular proteins associated with cellular vitamin D action.
Work with vitamin D-resistant New World primates has revealed novel cellular proteins involved in vitamin D action. An "intracellular vitamin D-binding protein" functions to bind vitamin D metabolites in the cell and enhances vitamin D action. By contrast, a "vitamin D response element-binding protein" inhibits vitamin D receptor binding to the DNA and is responsible for vitamin D resistance in New World primates.
Angelo
Giana
G
Mineral Bioavailability Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Wood
Richard J
RJ
Mayer
Jean
J
D000818:Animals; D002427:Cebidae / Q000502:physiology; D018167:Receptors, Calcitriol / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000235:genetics* / Q000378:metabolism*; D014809:Vitamin D-Binding Protein / Q000235:genetics* / Q000378:metabolism*
D018167:Receptors, Calcitriol; D014809:Vitamin D-Binding Protein; D014807:Vitamin D