title: Comment: CAPN10 alleles are associated with polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation infertility, hyperandrogenemia, and frequently insulin resistance. This study investigated whether polymorphisms in the CAPN10 gene are related with PCOS etiology. The allelic frequencies and genotypes of CAPN10 polymorphisms UCSNP-44, 43, 19, and 63 were determined in 55 well characterized women with polycystic ovaries and 93 unrelated healthy controls using spectrofluorimetric analyses and real-time PCR. Our data indicate that CAPN10 UCSNP-44 allele is associated with PCOS in the Spanish population (P = 0.01). These results support a role of Calpain 10 gene in PCOS susceptibility in humans.
authors.affiliation: Centro Avanzado de Fertilidad, Unidad de Reproducción y Genética Humana, Instituto Medico Serman, Jerez de la Frontera, Cádiz, Spain. alejandro.gonzalez@caf-jerez.com
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gonzalez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Abril
authors.forename: Alfredo
authors.initials: A
authors.lastname: Roca
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Aragón
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Figueroa
authors.forename: Pilar
authors.initials: P
authors.lastname: Velarde
authors.forename: José Luis
authors.initials: JL
authors.lastname: Royo
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Real
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D002154:Calpain / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D002154:Calpain; C415197:calpain 10