Lymphangiogenesis and cancer metastasis.
Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced metastatic process.
Stacker
Steven A
SA
Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia.
Achen
Marc G
MG
Jussila
Lotta
L
Baldwin
Megan E
ME
Alitalo
Kari
K
D000818:Animals; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008208:Lymphatic System / Q000254:growth & development / Q000378:metabolism / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction; D042643:Vascular Endothelial Growth Factor D
D006133:Growth Substances; D042643:Vascular Endothelial Growth Factor D