A rare association of primary biliary cirrhosis and pernicious anemia.
Primary biliary cirrhosis is often associated with autoimmune diseases. However, an association between primary biliary cirrhosis and pernicious anemia has rarely been reported. We report a patient with primary biliary cirrhosis associated with pernicious anemia and autoimmune gastritis. The patient was a 64-year-old Japanese woman who had been diagnosed as having primary biliary cirrhosis 5 years previously. She was readmitted with jaundice and macrocytic anemia. The diagnosis of pernicious anemia was confirmed by the low level of serum vitamin B12 and the presence of anti-parietal cell antibody and anti-intrinsic factor antibody. Pernicious anemia should be regarded as a possible complication of primary biliary cirrhosis.
Aoyama
Hajime
H
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Sakugawa
Hiroshi
H
Nakasone
Hiroki
H
Nakayoshi
Tomofumi
T
Kinjo
Akiko
A
Tamayose
Maki
M
Higa
Hajime
H
Uema
Eriko
E
Chinen
Takayuki
T
Tomiyama
Ryosaku
R
Uchima
Nobufumi
N
Kugai
Yukino
Y
Kinjo
Fukunori
F
Saito
Atsushi
A
Kinjo
Mitsuru
M
D000752:Anemia, Pernicious / Q000150:complications*; D001327:Autoimmune Diseases / Q000150:complications; D005260:Female; D005756:Gastritis / Q000150:complications; D006801:Humans; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008875:Middle Aged; D013270:Stomach / Q000473:pathology