A "bad responder" to statins.
We report the case of a man whose high-density lipoprotein cholesterol (HDL-C) and the ratios of total cholesterol to HDL-C and low-density lipoprotein cholesterol to HDL-C worsened dramatically during pravastatin treatment. After 3 years, pravastatin was replaced by fenofibrate. The result was spectacular. The HDL-C increased to at least twice the level obtained during pravastatin.
Devroey
Dirk
D
Department of General Practice, University of Brussels, Laarbeeklaan 103, B-1090 Brussels, Belgium. dirk.devroey@vub.ac.be
Betz
W
W
Coigniez
P
P
Lauwers
R
R
Velkeniers
B
B
D000924:Anticholesteremic Agents / Q000009:adverse effects*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000009:adverse effects*; D017211:Treatment Failure
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017035:Pravastatin