title: Detecting single molecules launched from liquid surfaces in a time-of-flight mass spectrometer using ultraviolet and infrared lasers.
abstract: The launch of molecules from liquid surfaces in a time of flight mass spectrometer has been investigated using different sample preparation techniques, and by exposing the liquid samples to two different laser wavelengths, 337 nm from a N2 ultraviolet laser and 10.6 microm from a CO2 infrared laser. The molecules were detected with cryodetectors measuring the energy of the individual molecules. We present insulin and lysozyme results from samples introduced into the vacuum through a micromachined silicon injector, and from samples consisting of a glycerol droplet deposited directly on the sample holder at the high voltage stage of the ion optics.
authors.affiliation: Institut de Physique, Université Neuchâtel, Switzerland. twerenbold@genspec.ch
authors.forename: Damian
authors.initials: D
authors.lastname: Twerenbold
authors.forename: Alexandre
authors.initials: A
authors.lastname: Netuschill
authors.forename: Nico
authors.initials: N
authors.lastname: de Rooij
authors.forename: Phillipe
authors.initials: P
authors.lastname: Luginbuhl
authors.forename: Daniel
authors.initials: D
authors.lastname: Gerbe
authors.forename: Dominique
authors.initials: D
authors.lastname: Gritti
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gonin
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rossel
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vuilleumier
mesh_terms: D005990:Glycerol / Q000032:analysis; D007328:Insulin / Q000032:analysis; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D008904:Miniaturization; D009113:Muramidase / Q000032:analysis; D012996:Solutions / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation / Q000379:methods
chemical_list: D007328:Insulin; D012996:Solutions; D009113:Muramidase; D005990:Glycerol