[Granulocyte sarcoma of the pancreas without extra-pancreatic location].
BACKGROUND
Granulocyte sarcoma (GS), also known as chloroma, is a localized malignant tumor composed of myeloid cells, the diagnosis of which is difficult. The pancreatic location and recurrence, aside from any context of malignant hemopathy, are exceptional.


METHODS
A 31-year-old woman developed an isolated and recurrent granulocyte sarcoma of the pancreas, without any context of a malignant hemopathy. The diagnosis retained on extemporaneous examination was an adenocarcinoma of the pancreas, because of the non-specific necrotic nature of the tumor. The immuno-histochemical exploration corrected the diagnosis. Despite local surgery, an isolated tumor recurred 6 months later. This relapse was treated with radiotherapy followed by heavy chemotherapy, identical to that applied in acute myeloblastic leukemia (AML). Ten months later, remission was stable and complete.


CONCLUSIONS
Isolated granulocyte sarcomas located in the pancreas are exceptional and have often led to initial erroneous diagnosis. Immuno-histochemical methods are essential in order to obtain correct diagnosis. Despite the localized nature of the tumor, intensive AML-type chemotherapy is necessary.
Dimicoli
S
S
Service d'Hématologie et de Médecine Interne, CHU Nancy-Brabois, Allée du Morvan, 54511 Vandoeuvre.
Feugier
P
P
Delaby
P
P
Cannard
L
L
Bland
V
V
Witz
F
F
Hulin
C
C
Guerci
A
A
Labouyrie
E
E
Lederlin
P
P
D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D011878:Radiotherapy; D023981:Sarcoma, Myeloid / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery