Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity.
We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1alpha (IL-1alpha), IL-1beta and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS).
Mann
C L A
CL
Keele Multiple Sclerosis Research Group, Department of Neurology, North Staffordshire Hospital, Stoke on Trent, England, ST4 7LN, Staffordshire, UK. mann@cwcom.net
Davies
M B
MB
Stevenson
V L
VL
Leary
S M
SM
Boggild
M D
MD
Ko Ko
C
C
Jones
P W
PW
Fryer
A A
AA
Strange
R C
RC
Thompson
A J
AJ
Hawkins
C P
CP
D000276:Adjuvants, Immunologic / Q000235:genetics*; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006720:Homozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics* / Q000276:immunology; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors; D012795:Sialoglycoproteins / Q000235:genetics* / Q000276:immunology
D000276:Adjuvants, Immunologic; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D012795:Sialoglycoproteins