title: Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity.
abstract: We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1alpha (IL-1alpha), IL-1beta and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS).
authors.affiliation: Keele Multiple Sclerosis Research Group, Department of Neurology, North Staffordshire Hospital, Stoke on Trent, England, ST4 7LN, Staffordshire, UK. mann@cwcom.net
authors.forename: C L A
authors.initials: CL
authors.lastname: Mann
authors.forename: M B
authors.initials: MB
authors.lastname: Davies
authors.forename: V L
authors.initials: VL
authors.lastname: Stevenson
authors.forename: S M
authors.initials: SM
authors.lastname: Leary
authors.forename: M D
authors.initials: MD
authors.lastname: Boggild
authors.forename: C
authors.initials: C
authors.lastname: Ko Ko
authors.forename: P W
authors.initials: PW
authors.lastname: Jones
authors.forename: A A
authors.initials: AA
authors.lastname: Fryer
authors.forename: R C
authors.initials: RC
authors.lastname: Strange
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: C P
authors.initials: CP
authors.lastname: Hawkins
mesh_terms: D000276:Adjuvants, Immunologic / Q000235:genetics*; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006720:Homozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics* / Q000276:immunology; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors; D012795:Sialoglycoproteins / Q000235:genetics* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D012795:Sialoglycoproteins