[Fentanyl administration during sevoflurane anesthesia suppresses spike waves from epileptic focus on electrocorticogram].
A 36-year-old man with intractable epileptic seizures underwent insertion of subdural electrodes on bilateral temporal lobes under air-oxygen-sevoflurane anesthesia. After the completion of the operation, we measured electrocorticogram at end-tidal sevoflurane concentration of 2.5%, 1.5%, and 1.5% with 0.1 mg intravenous fentanyl. When sevoflurane concentration was reduced to 1.5%, the incidence and voltage of the spike waves on electrocorticogram were reduced. When 0.1 mg fentanyl was intravenously administrated during 1.5% sevoflurane anesthesia, the frequency of the spike waves was further reduced. Caution should be taken when using sevoflurane-fentanyl anesthesia because this combination may interrupt identification of epileptic focus on intraoperative electrocorticogram.
Koyama
Shinichi
S
Department of Anesthesiology, Osaka City University Medical School, Osaka 545-8586.
Makino
Yuriko
Y
Tanaka
Kazuo
K
Morino
Michiharu
M
Nishikawa
Kiyonobu
K
Asada
Akira
A
D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000328:Adult; D000769:Anesthesia, Inhalation; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000503:physiopathology* / Q000601:surgery; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D000077149:Sevoflurane
D000759:Adjuvants, Anesthesia; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D005283:Fentanyl