title: IL-10 in myeloma cells.
abstract: In addition to interleukin (IL)-6, IL-10 is considered as one of the most important cytokines regulating the proliferation and cellular characteristics of myeloma cells. It is still unclear from the clinical data how serum IL-10 levels of various stages of myeloma, are related to clinical manifestations of this disease. Several studies have reported that IL-10 affects myeloma cells by stimulating secondary signals for cell proliferation through oncostatin M (OSM) and IL-11. In experiments using human myeloma cell lines established at our laboratory, IL-10 seemed to be expressed in half of myelomas simultaneously with OSM, and to be correlated with c-maf, a transcription factor, which has been known to be overexpressed in myelomas with t(14;16)(q32;q23). In addition, IL-10 abolishes all trans retinoic acid (ATRA)-induced growth inhibition of myeloma cells. The expression and production of IL-10 in myeloma patients may be important for sub-categorization and the establishment of a case-oriented therapy.
authors.affiliation: Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama, Japan. takemi@med.kawasaki-m.ac.jp
authors.forename: Takemi
authors.initials: T
authors.lastname: Otsuki
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yata
authors.forename: Haruko
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: Masako
authors.initials: M
authors.lastname: Uno
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Fujii
authors.forename: Hideho
authors.initials: H
authors.lastname: Wada
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugihara
authors.forename: Ayako
authors.initials: A
authors.lastname: Ueki
mesh_terms: D002455:Cell Division; D016207:Cytokines / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics / Q000502:physiology*; D009101:Multiple Myeloma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D016207:Cytokines; D016753:Interleukin-10; D014212:Tretinoin