New therapies and vaccines for bacterial meningitis.
Acute bacterial meningitis remains an important cause of morbidity and mortality worldwide. There have recently been major advances in the prevention of the major causes of bacterial meningitis following improvements in vaccinology. The success of immunisation against Haemophilus influenzae type b infection is being mirrored with serogroup C conjugated meningococcal vaccine and pneumococcal conjugate vaccine. However, there remain major challenges, notably, serogroup B meningococcal infection and shifts in epidemiology caused by vaccine introduction. In addition, much of the world's population is unvaccinated. Therefore, improvements in management of acute bacterial meningitis are vital. In this review we attempt to summarise important advances in both prevention and treatment of acute bacterial meningitis.
Foster
Caroline
C
Department of Paediatrics, Imperial College School of Medicine at St. Mary's Hospital, Praed Street, London, W2 1NY, UK.
Nadel
Simon
S
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002648:Child; D018073:Haemophilus Vaccines / Q000008:administration & dosage; D019741:Haemophilus influenzae type b / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D008583:Meningitis, Haemophilus / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D008585:Meningitis, Meningococcal / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines; D018073:Haemophilus Vaccines; D022401:Meningococcal Vaccines