Expression of collagen type II, S100B, S100A2 and osteocalcin in chondroblastoma and chondromyxoid fibroma.
Chondroblastoma and chondromyxoid fibroma (CMF) has been investigated in numerous histological studies, but its biological nature and histogenetic origin are still a matter of debate. We evaluated the expression of type II collagen, S100A2, S100B, and osteocalcin to study the matrix biochemistry and phenotype of the neoplastic cells in these tumors. Immunohistochemically, the expression of type II collagen was diffuse in 15 cases (75%) among total 20 chondroblastomas and 12 (85.7%) among total 14 CMFs. The expression of S100B was also diffuse in all cases (100%) of chondroblastomas and 12 cases (85.7%) of CMFs. We were able to obtain the expression of S100A2, focally. The expression of osteocalcin was focally noted in 18 cases (90%) of chondroblastomas and 8 cases (57.1%) of CMFs. In conclusion, our data support that chondroblastoma and CMF are a distinct tumor entity with the basic expression of chondroid markers. But these tumors also show histologic diversity with focal co-expression of osteoid markers.
Park
Hye-Rim
HR
Department of Pathology, College of Medicine, Hallym University, Anyang, Korea.
Park
Yong-Koo
YK
Jang
Kee Taek
KT
Unni
K Krishnan
KK
D001859:Bone Neoplasms / Q000378:metabolism*; D002630:Chemotactic Factors / Q000096:biosynthesis*; D002804:Chondroblastoma / Q000378:metabolism*; D024043:Collagen Type II / Q000096:biosynthesis*; D005350:Fibroma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D015675:Osteocalcin / Q000096:biosynthesis*; D010641:Phenotype; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000096:biosynthesis*
D002630:Chemotactic Factors; D024043:Collagen Type II; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C098997:S100A2 protein, human; C579160:S100B protein, human; D015675:Osteocalcin