title: [The usefulness of 11C-Choline-positron emission tomography in the diagnosis of sclerosing hemangioma of the lung--a case report].
abstract: A 64-year-old woman was admitted to our hospital for further examination of an abnormal shadow in the left lung, that had grown slowly for 9 years. Bronchial brushing cytology was performed under bronchoscopy, but was negative for malignancy and for other significant findings. 11C-Choline-positron emission tomography (11C-Choline-PET) showed medium-level uptake in the mass lesion in the S 6 lobe of the left lung, but 18F-fluorodeoxyglucose-positron emission tomography (18FDG-PET) did not yield any such result. These findings suggested the presence of a slowly growing benign tumor, or a neoplastic disease, such as a potentially malignant tumor or a low-grade malignancy. To arrive at a diagnosis, a left partial lobectomy was performed on January 29, 2001. The microscopic findings of this mass lesion showed a solid, hemorrhagic pattern; papillary projections into spaces covered or lined by cuboidal cells, and sheets of round to polygonal cells. The histological diagnosis of this tumor was a sclerosing hemangioma. Recently, 18FDG-PET has been proven to be a clinically useful tool for the detection and staging of malignant tumors, and the follow-up of malignant diseases after treatment; while 11C-choline was recently reported to be a new PET tracer used to visualize various malignancies. The uptake of 11C-choline in tumors represents the rate of tumor cell duplication. It is suggested that 11C-choline-PET may be useful in the diagnosis of sclerosing hemangioma, as in this case.
authors.affiliation: Department of Respiratory Medicine, International Medical Center of Japan, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
authors.forename: Etsu
authors.initials: E
authors.lastname: Tsuduki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawana
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kudo
authors.forename: Tomokiyo
authors.initials: T
authors.lastname: Nomura
authors.forename: Takatomo
authors.initials: T
authors.lastname: Morita
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Morita
mesh_terms: D002250:Carbon Radioisotopes; D002794:Choline; D005260:Female; D019788:Fluorodeoxyglucose F18; D006391:Hemangioma / Q000000981:diagnostic imaging*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008875:Middle Aged; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D002794:Choline