Memory CD8(+) T cells undergo peripheral tolerance.
Memory T cells differ from naive T cells in that they respond more rapidly and in greater numbers. In addition, memory T cells are generally believed to be less susceptible to tolerance induction than naive T cells. In this study, we show that this is not the case. Using two different methods of tolerance induction, peptide-induced tolerance and crosstolerance, we present evidence that memory CD8(+) T cells are as susceptible to tolerance as naive cells. These results have a direct impact on manipulating T cell responses to self-antigens in order to improve immunotherapy of cancer and autoimmune diseases.
Kreuwel
Huub T C
HT
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Aung
Sandra
S
Silao
Cheryl
C
Sherman
Linda A
LA
D000818:Animals; D000831:Animals, Newborn; D001324:Autoantigens / Q000276:immunology; D002460:Cell Line; D002999:Clone Cells; D003920:Diabetes Mellitus / Q000276:immunology; D019672:Genes, T-Cell Receptor; D006388:Hemagglutinins / Q000276:immunology / Q000378:metabolism; D007108:Immune Tolerance; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010179:Pancreas / Q000276:immunology; D010455:Peptides / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D001324:Autoantigens; D006388:Hemagglutinins; D010455:Peptides