Point mutation in the alpha helix of the HLA-C alpha2 domain generates a novel HLA-C allele,HLA-Cw*0106, in a Han Chinese individual in Taiwan.
We report herein the identification of a new HLA-C allele using sequence-based typing (SBT). This novel allele, HLA-Cw*0106, was found in a Han Chinese individual from Taiwan. This individual was typed using SBT as having a class I HLA genotype of HLA-A*0206/0207, HLA-B*4601/5601, and HLA-Cw*0102/0106. This new allele differs from HLA-Cw*0102 in one of the nucleotides of the polymorphic exon 3 at codon 152 (GAG-->GTG; E152V). This residue is located in the alpha helix of the HLA-C alpha2 domain and may have the potential to affect the binding of HLA-C molecules with antigenic peptides and/or the interactions with the T cell receptor. This new allele was detected in a few individuals of Han Chinese in Taiwan, but has not yet been observed in the aboriginal populations in Taiwan.
Wu
S
S
Tzu Chi University, Taiwan, ROC. shaokee@mail.tcu.edu.tw
Lai
C-Y
CY
Lai
S-M
SM
Chen
S-P
SP
Chou
F-C
FC
Shiao
Y-M
YM
Huang
C-S
CS
D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D015236:HLA-C Antigens / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D017433:Protein Structure, Secondary; D013624:Taiwan
D015236:HLA-C Antigens; C471431:HLA-C*01:06 antigen