Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats.
The methanol extracts of Hibiscus sabdariffa (p < 0.01) showed a significant dose dependent relaxant effect (IC50) = 350 microM) on rat ileal strip comparable to the effect shown by nifedipin and papaverine as reference compounds. Similarly, the extract when administered intraperitoneally significantly (p < 0.05-0.01) reduced the intestinal transit (13%-35%) in rats (IC50, = 250 microM). The extracts (40% +/- 04%) and nifedipin (51% +/- 05%) also potentiated the diarrhoea inducing effect of castor oil (IC50 = 350 microM). It is postulated that these effects are possibly generated by constituents such as quercetin and eugenol via a Ca2+ channel modulated mode of action.
Salah
A M
AM
National Center for Natural Product Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University 38677, USA.
Gathumbi
J
J
Vierling
W
W
D000818:Animals; D002368:Castor Oil / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005769:Gastrointestinal Motility / Q000187:drug effects*; D031584:Hibiscus; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D000432:Methanol / Q000737:chemistry; D009543:Nifedipine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D015016:Yohimbine / Q000494:pharmacology
D005765:Gastrointestinal Agents; D010936:Plant Extracts; D015016:Yohimbine; D002368:Castor Oil; D009543:Nifedipine; D000432:Methanol