Effect of jianpiyiwei capsule on gastric precancerous lesions in rats.
OBJECTIVE
To evaluate the therapeutic effect of compound Chinese drugs, Jianpiyiwei capsule (JPYW) on gastric precancerous lesions in rats and to explore its mechanism of action.


METHODS
Model of gastric precancerous lesions was constructed in male Wistar rats: a metal spring was inserted and fixed through pyloric sphincter. One week after recovery, each rat was given 50-60 degrees hot paste containing 150 g/L NaCl 2 mL orally, twice a week for 15 weeks. Then 10 normal and 11 model rats were anaesthetized, after the measurement of gastric mucosa blood flow (GMBF), the rats were killed and the mucosal hexosamines and malonic dialdehyde (MDA) were measured. The morphological changes of gastric mucosa were observed macroscopically and microscopically, and by an automatic imaging analysis system. Other rats were treated with JPYW 1.5 g/kg.d(-1) or 4.5 g/kg.d(-1), or distilled water as negative control respectively (n=10 in each group). After 12 weeks, all the rats were examined as above.


RESULTS
The gastric mucosa of model rats showed chronic atrophic gastritis with dysplasia and intestinal metaplasia (IM), GMBF and hexosamine content were reduced significantly and MDA was increased as compared to the normal group (P<0.01). After 12 weeks treatment, the pathological changes of the negative control group became worsened, while in JPYW treated groups the changes were modified with significant increase of GMBF and reduction of MDA, although the hexosamine concentration increased only mildly.


CONCLUSIONS
JPYW increases GMBF and reduces MDA content in gastric mucosa and has therapeutic effects on gastric precancerous lesions.
Shi
Xue-Ying
XY
Taiyuan Research Treatment Center of Digestive Disease, 77 Shuangta Xiejie, Taiyuan 030001, Shanxi Province China.
Zhao
Feng-Zhi
FZ
Dai
Xin
X
Ma
Lian-Sheng
LS
Dong
Xiu-Yu
XY
Fang
Jie
J
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D006595:Hexosamines / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D011230:Precancerous Conditions / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013274:Stomach Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology
D004365:Drugs, Chinese Herbal; D006595:Hexosamines; D008315:Malondialdehyde