title: [Conjugated vaccines].
abstract: Conjugate vaccines extend the vaccinal prevention for children to more diseases. Conjugating the capsular polysaccharide to a carrier protein transforms a T-independent antigen in a T-dependent, allowing protection of the children (before 2 years of age) against Haemophilus influenzae type b, meningococcal C and pneumococcal infections. This article reviews the 3 conjugate vaccines and their results with focus on some questions: antigens interference in the immunological response, serological subrogate for protection, herd immunity and replacement of circulating serotypes.
authors.affiliation: Unité d'Epidémiologie pédiatrique et Vaccination, Ecole de Santé publique, U.L.B.
authors.forename: B
authors.initials: B
authors.lastname: Swennen
authors.forename: J
authors.initials: J
authors.lastname: Sternon
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D001530:Belgium / Q000453:epidemiology; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D006192:Haemophilus Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000276:immunology*; D019741:Haemophilus influenzae type b; D006801:Humans; D017589:Immunization Programs / Q000458:organization & administration; D008213:Lymphocyte Activation / Q000276:immunology; D008589:Meningococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000276:immunology*; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination / Q000379:methods / Q000592:standards; D018074:Vaccines, Conjugate / Q000276:immunology*
chemical_list: D018073:Haemophilus Vaccines; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate