title: Methylenedioxy- and methoxyflavones from Melicope coodeana syn. Euodia simplex.
abstract: Three new natural products, 3,8-dimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone, 3,6,8-trimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone and 3,6,8,3',4'-pentamethoxy-5,7-dihydroxyflavone were isolated from Melicope coodeana syn. Euodia simplex (Rutaceae) along with 3,6,3'-trimethoxy-5,7,4'-trihydroxyflavone and 3,3'-dimethoxy-5,7,4'-trihydroxyflavone. The structural assignments are based on (1)H and (13)C NMR data, including discussion of the chemical shifts of C-2 in 3,5-dihydroxy- and 3-methoxy-5-hydroxyflavones. The presence of highly methoxylated and methylenedioxyflavones is characteristic of the genus Melicope, and the present findings support the recent transfer of Euodia simplex to Melicope.
authors.affiliation: Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Henrik T
authors.initials: HT
authors.lastname: Simonsen
authors.forename: Michael D
authors.initials: MD
authors.lastname: Larsen
authors.forename: Merete W
authors.initials: MW
authors.lastname: Nielsen
authors.forename: Anne
authors.initials: A
authors.lastname: Adsersen
authors.forename: Carl Erik
authors.initials: CE
authors.lastname: Olsen
authors.forename: Dominique
authors.initials: D
authors.lastname: Strasberg
authors.forename: Ulla W
authors.initials: UW
authors.lastname: Smitt
authors.forename: Jerzy W
authors.initials: JW
authors.lastname: Jaroszewski
mesh_terms: D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D027821:Rutaceae / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D005419:Flavonoids