title: Reduced production of interferon-gamma but not interleukin-10 in bipolar mania and subsequent remission.
abstract: BACKGROUND
  Activation of inflammatory response system (IRS) is suggested by increased levels of plasma soluble interleukin-2 receptor (sIL-2R) in patients with bipolar mania. The reasons for changes in stimulated interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) production in bipolar mania along with subsequent remission remain unclear.
  
  
  METHODS
  We measured phytohemagglutinin (PHA)-stimulated IFN-gamma and IL-10 production in 20 physically healthy inpatients aged between 18 and 45 years with bipolar mania (DSM-IV) using Young Mania Rating Scale (YMRS) scores > or = 26 and in subsequent remission (YMRS < or = 12), as well as in 15 age- and sex-matched healthy normal controls.
  
  
  RESULTS
  The mean values of IFN-gamma production in patients in acute mania and in subsequent remission were significantly lower than those of healthy controls (P=0.0004, P=0.0005, respectively). There was no significant difference in IL-10 production between bipolar patients in acute mania as well as in subsequent remission and healthy controls. In acute mania, the mean values of IFN-gamma and IL-10 production in medicated patients (n = 13) did not differ from those of drug-free patients (n = 7). Other clinical variables had no effect on IFN-gamma and IL-10 production.
  
  
  CONCLUSIONS
  The uncontrolled medication, small sample size of the bipolar individuals, and some immune re-measurements prior to full remission periods, limit generalization from the data in this study.
  
  
  CONCLUSIONS
  Reduced production of IFN-gamma without alternation of IL-10 in bipolar mania and subsequent remission suggest that the immune modulation may vary in patients with different major psychiatric disorders.
authors.affiliation: Department of Psychiatry, School of Medicine, Taipei Medical University Hospital, Taipei Medical University Wang Fang Hospital, Taipei, Taiwan [corrected].
authors.forename: Kuan-Pin
authors.initials: KP
authors.lastname: Su
authors.forename: Sy-Jye C
authors.initials: SJ
authors.lastname: Leu
authors.forename: Yi-Yuan
authors.initials: YY
authors.lastname: Yang
authors.forename: Winston W
authors.initials: WW
authors.lastname: Shen
authors.forename: Yech-Mei
authors.initials: YM
authors.lastname: Chou
authors.forename: Shang-Ying M
authors.initials: SY
authors.lastname: Tsai
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000276:immunology* / Q000523:psychology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D012720:Severity of Illness Index
chemical_list: D016753:Interleukin-10; D007371:Interferon-gamma