Helicobacter pylori seropositivity and IL-1B C-31T polymorphism among Japanese Brazilians.
We reported previously that anti-Helicobacter pylori antibody seropositivity (HP+) had an association with interleukin 1B (IL-1B) C-31T genotype, especially among smokers. This study examined the association for Japanese Brazilians. In this cross-sectional study, voluntary participation was announced through Japanese Brazilian communities in Sao Paulo, Curitiba, Mogi das Cruzes, and Mirandopolis; 963 Japanese Brazilians (399 males and 564 females) aged 33-69 years participated. Lifestyle data and peripheral blood were collected. An anti-HP IgG antibody test and genotyping for IL-1B C-31T and IL-1RN 86 bp VNTR were independently conducted. The genotype frequency of the IL-1B polymorphism among 947 individuals was 23.9% for C/C genotype, 45.6% for C/T genotype, and 30.5% for T/T genotype. Sex-age-adjusted odds ratio (aOR) of HP+ was 1.30 (95% confidence interval, 0.94-1.81) for C/T genotype and 1.45 (1.02-2.07) for T/T genotype relative to C/C genotype. The aOR for 127 current smokers was 2.45 (0.91-6.55) for C/T and 3.49 (1.17-10.46) for T/T, while that for 667 never smokers was 1.21 (0.82-1.78) and 1.36 (0.90-2.05), respectively. The corresponding figures were 2.42 (1.16-5.02) and 3.00 (1.33-6.78) for 226 current drinkers, and 1.21 (0.82-1.78) and 1.36 (0.90-2.05) for 667 non-drinkers. The difference in the OR was observed for milk consumption, salty pickled vegetable eating, and physical exercise practice. 4/4 Genotype of IL-1RN 86 bp VNTR was 84.8%, and had no association with the HP seropositivity. The observed association between HP+ and IL-1B -31TT indicated that the genetic trait also influences the susceptibility to HP for Japanese in Brazil.
Uno
Miyuki
M
Department of Clinical Laboratory, Aichi Cancer Center, Kanokoden, Chikusa-ku, Nagoya, Japan.
Hamajima
Nobuyuki
N
Ito
Lucy S
LS
Oba
Sueli M
SM
Marie
Suely K N
SK
Shinjo
Samuel K
SK
Onda
Hiroyuki
H
Saito
Toshiko
T
Takezaki
Toshiro
T
Tajima
Kazuo
K
Tominaga
Suketami
S
D000328:Adult; D000367:Age Factors; D000368:Aged; D001938:Brazil; D005260:Female; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D012907:Smoking
D007375:Interleukin-1