title: Hemodynamic effects of exogenous adrenomedullin in healthy and endotoxemic sheep.
abstract: Adrenomedullin (AM) is a vasodilatory peptide hormone, playing a key role in the regulation of cardiovascular homeostasis. In view of the circulatory failure in sepsis, it is still debated as to whether the occurrence of vascular hyporeactivity against AM plays a causative or protective role. This study was designed as a prospective, controlled trial to elucidate the hemodynamic response following a titrating infusion of human AM in healthy and endotoxemic sheep. ANOVA demonstrated that AM infusion produced hypotension and tachycardia, and increased cardiac index in a dose-dependent manner, both in healthy and endotoxemic sheep. In addition, AM application reduced pulmonary vascular resistance index in ovine endotoxemia (P=0.02). These findings confirm that AM produces a hyperdynamic circulation, in the presence and absence of systemic inflammation. Further, exogenous AM could possibly be a useful adjunct in the common setting of sepsis-associated pulmonary hypertension.
authors.affiliation: Department of Anaesthesiology and Intensive Care, University of Münster, Albert-Schweitzer-Strasse 33, 48149, Münster, Germany. mwestpha@uni-muenster.de
authors.forename: Martin
authors.initials: M
authors.lastname: Westphal
authors.forename: Henning
authors.initials: H
authors.lastname: Stubbe
authors.forename: Hans Georg
authors.initials: HG
authors.lastname: Bone
authors.forename: Fritz
authors.initials: F
authors.lastname: Daudel
authors.forename: Sebastian
authors.initials: S
authors.lastname: Vocke
authors.forename: Hugo
authors.initials: H
authors.lastname: Van Aken
authors.forename: Michael
authors.initials: M
authors.lastname: Booke
mesh_terms: D053607:Adrenomedullin; D000818:Animals; D019446:Endotoxemia / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D012756:Sheep
chemical_list: D010455:Peptides; D053607:Adrenomedullin