[Red cell phospholipid composition in children with neurological pathology].
Changes of red cell membrane phospholipid composition were studied in children with different neurological disorders--cerebral palsy, organic CNS damages and perinatal encephalopathy. The percentages of phosphatidylcholin and, in some cases, of phosphoglycerides increase depending on the disease type. The above changes were determined by craniocerebral innervation disturbances and concerned mainly the content of phosphatidylcholin, phosphatidylserine and phosphatidylethanolamin. The determination analysis established that the changes of erythrocytes phospholipid content correlated with clinical state severity and intellectual development of children, and to depend on the disease type and may affect directly development/disturbance of craniocerebral innervation and intellectual development. The age changes were shown to influence phosphatid acid percentage in the patients.
Vasil'eva
E M
EM
Bakanov
M I
MI
Gordeev
G F
GF
Poddubnaia
A E
AE
Shor
T A
TA
D001921:Brain / Q000378:metabolism / Q000473:pathology; D002462:Cell Membrane; D002547:Cerebral Palsy / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007223:Infant; D010713:Phosphatidylcholines / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000097:blood*; D012886:Skull / Q000294:innervation
D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D010743:Phospholipids