Biological responses of tight junction to ionizing radiation and electromagnetic field expostion.
The tight junctions form and regulate the paracellular barrier in the intercellular spaces between epithelial and endothelial cells. They play important roles in the cellular and pathological processes, which follow exposure to radiation. Therefore, analysis of their changes upon different kind of irradiation may help to understand the basic events governing their function and give important information for the radiobiological research and clinical practice as well. The immunohistochemical data on the distribution of occludin presented here demonstrate the breakdown of tight junctions in Madin Darby kidney cells exposed to ionizing irradiation and show, on the other hand that magnetic field exposures upon 100 microT leave the occludin staining pattern intact.
Somosy
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Fodor József National Center of Public Health, National Frédéric Joliot-Curie Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary. somosy@hp.osski.hu
Bognár
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Thuróczy
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Köteles
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D000818:Animals; D002460:Cell Line; D004285:Dogs; D004574:Electromagnetic Fields; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000032:analysis / Q000528:radiation effects; D062793:Occludin; D011839:Radiation, Ionizing; D019108:Tight Junctions / Q000528:radiation effects*
D008565:Membrane Proteins; D062793:Occludin