title: Strain improvement studies for cephalosporin C production by Cephalosporium acremonium.
abstract: Treatment of spore suspension of Cephalosporium acremonium ATCC 48272 with UV rays and N-methyl-N-nitro-N-nitrosoguanidine (NTG) induced mutants capable of producing higher yields of cephalosporin C. Antibiotic yield was improved from 630 micrograms/ml to 1995 micrograms/ml of the broth resulting in a high yielding mutant.
authors.affiliation: Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India. adikunamneni@rediffmail.com
authors.forename: P
authors.initials: P
authors.lastname: Ellaiah
authors.forename: K
authors.initials: K
authors.lastname: Adinarayana
authors.forename: G Murali
authors.initials: GM
authors.lastname: Chand
authors.forename: G S V
authors.initials: GS
authors.lastname: Subramanyam
authors.forename: B
authors.initials: B
authors.lastname: Srinivasulu
mesh_terms: D000164:Acremonium / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D002511:Cephalosporins / Q000096:biosynthesis*; D005285:Fermentation; D009153:Mutagens / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D002511:Cephalosporins; D009153:Mutagens; C025163:cephalosporin C