Effects of oral contraceptives with low-dose estrogen and desogestrel on leptin concentrations.
OBJECTIVE
To evaluate short-term leptin concentrations in women who use low-dose oral contraceptives.


METHODS
From 15 women without medical problems, venous blood samples were taken: basal, between days 3 and 5 of menstruation, and in the third month. The Human Leptin Radioimmunassay Kit (Linco Research, Inc., St. Charles, Missouri) was used for leptin measurement. Statistical analysis was done with the Wilcoxon test.


RESULTS
The average patient age was 30.1 +/- 6.7 years. The basal leptin concentrations and leptin concentrations at the third month were 22.17 +/- 8.85 and 23.04 +/- 6.77 ng/mL, respectively. This increase was not statistically significant.


CONCLUSIONS
Oral contraceptives with low-dose estrogen and desogestrel do not affect leptin concentrations in a three-month period.
Sağsöz
Nevin
N
Department of Obstetrics and Gynecology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey. nsagsoz@isbank.net.tr
Akçay
Fatih
F
Bayram
Merih
M
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage* / Q000097:blood; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000097:blood; D017135:Desogestrel / Q000008:administration & dosage; D004967:Estrogens / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004967:Estrogens; D007328:Insulin; D020738:Leptin; D017135:Desogestrel