Precursor B-cell lymphoblastic lymphoma/leukemia presenting as osteoblastic bone lesions.
Lymphoblastic lymphoma is a neoplasm of precursors lymphoid cells morphologically indistinguishable from those of acute lymphoblastic leukemia. Approximately 10% to 20% of cases are of the precursor B-cell (P-BLL) phenotype. This type of lymphoma most often manifests in the skin and lymph nodes. In recent years more case reports of P-BLL presenting as lytic bone lesions have appeared in the literature. We describe an interesting case of P-BLL/leukemia that initially presented as an osteoblastic bone lesion and discuss the differential diagnosis from a pathologic-radiologic standpoint.
Recine
Monica
M
Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
Castellano-Sanchez
Amilcar A
AA
Sheldon
Jerome
J
Schwartz
Michael
M
Cabello-Inchausti
Beria
B
D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010006:Osteoblasts / Q000000981:diagnostic imaging / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed