Microwave-assisted solid-phase synthesis of 5-carboxamido-N-acetyltryptamine derivatives.
[reaction: see text] The synthesis of the indole skeleton of new melatoninergic analogues was realized using solid-phase methodology in association with microwave irradiation. This combination speeds up the solid-phase drug discovery process in rigorously established conditions.
Fînaru
Adriana
A
Institut de Chimie Organique et Analytique, UMR-CNRS 6005, Université d'Orléans, rue de Chartres, BP 6759, France.
Berthault
Aurélie
A
Besson
Thierry
T
Guillaumet
Gérald
G
Berteina-Raboin
Sabine
S