title: Dose-response relationships of intranasal cholecystokinin and the P300 event-related brain potential.
abstract: The gut and brain peptide cholecystokinin (CCK) has been found to improve controlled stimulus processing and attention as indicated by the late positive complex (LPC) of the event-related brain potentials (ERPs). A direct nose-brain pathway for cortical effects of intranasally administered CCK-8S has been described, although the precise transmission within this pathway is still unknown. The present study compared the effects of two doses of CCK-8S (10 and 20 microg) and placebo after intranasal administration on the LPC of the ERP in healthy male and female subjects to further elucidate mechanisms of this nose-brain pathway. ERPs were recorded in an oddball-paradigm. Results showed that both doses of CCK-8S induced a positive shift of the ERP. This effect did not differ between the 10 and 20 microg dosage of CCK-8S. The results indicate that a saturable mechanism may be responsible for the transmission of CCK-8S from the nose into the brain, since both doses of CCK-8S induced comparable increases of the ERP subcomponents.
authors.affiliation: Clinical Psychology, Heinrich-Heine University of Duesseldorf, Germany. denecke@uni-duesseldorf.de
authors.forename: Heide
authors.initials: H
authors.lastname: Denecke
authors.forename: Nadine
authors.initials: N
authors.lastname: Czehak
authors.forename: Reinhard
authors.initials: R
authors.lastname: Pietrowsky
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D001519:Behavior / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male
chemical_list: D002766:Cholecystokinin; D006854:Hydrocortisone