Recruiting volunteers for a multisite phase I/II HIV preventive vaccine trial in Thailand.
Factors believed to be predictive of retention through the recruitment and screening processes for preventive HIV trials were investigated in a large multisite phase I/II HIV vaccine trial in Thailand. Retention through recruitment was equal to or greater than in previous smaller trials with similar populations. The data suggested that recruitment proceeded in a stepwise manner with different influences at each step. Demographic and motivational variables were most important in predicting retention in making and keeping screening appointments. Altruistic or mixed altruistic and nonaltruistic motives were associated with greater retention. Laboratory/medical variables appeared to be the main influence on retention during screening, although some volunteers withdrew for different reasons. The frequent presence of mixed (altruistic and nonaltruistic) motives at initial contact suggests that motivation for trials is more complex than has been previously acknowledged.
Thapinta
Darawan
D
Faculty of Nursing and Research Institute of Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
Jenkins
Richard A
RA
Morgan
Patricia A
PA
Chiu
Joseph
J
Boenim
Wantanee
W
Bussaratid
Valai
V
Chaddic
Catherine
C
Naksrisook
Supa
S
Phonrat
Benjaluck
B
Sirijongdee
Nampueng
N
Sornsathapornkul
Pornchai
P
Sontirat
Auchara
A
Srisaengchai
Prasong
P
Suwanarach
Chanmet
C
Wongkamhaeng
Siriluck
S
Brown
Arthur E
AE
Khamboonruang
Chirasak
C
Nitayaphan
Sorachai
S
Pitisuttithum
Punnee
P
Thongchareon
Prasert
P
D016915:AIDS Vaccines; D000328:Adult; D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D017322:Clinical Trials, Phase II as Topic / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic / Q000379:methods*; D018579:Patient Selection; D013785:Thailand
D016915:AIDS Vaccines