title: Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine.
abstract: Spectroscopic evidence is presented for the formation of a carbinolamine interchain cross-link in 5'-CpG-3' sequences, arising from the acrolein adduct gamma-OH-PdG. This may be important in understanding biological processing of acrolein-induced DNA damage in CpG sequences.
authors.affiliation: Department of Chemistry, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA.
authors.forename: Hye-Young H
authors.initials: HY
authors.lastname: Kim
authors.forename: Markus
authors.initials: M
authors.lastname: Voehler
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Harris
authors.forename: Michael P
authors.initials: MP
authors.lastname: Stone
mesh_terms: D000171:Acrolein / Q000737:chemistry*; D018899:CpG Islands; D018736:DNA Adducts / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011688:Purinones / Q000737:chemistry*
chemical_list: D018736:DNA Adducts; D011688:Purinones; D000171:Acrolein