Checking cell size in yeast.
To remain viable, cells have to coordinate cell growth with cell division. In yeast, this occurs at two control points: the boundaries between G1 and S phases, also known as Start, and between G2 and M phases. Theoretically, coordination can be achieved by independent regulation of growth and division, or by participation of surveillance mechanisms in which cell size feeds back into cell-cycle control. This article discusses recent advances in the identification of sizing mechanisms in budding and in fission yeast, and how these mechanisms integrate with environmental stimuli. A comparison of the G1-S and G2-M size-control modules in the two species reveals a degree of conservation higher than previously thought. This reinforces the notion that internal sizing could be a conserved feature of cell-cycle control throughout eukaryotes.
Rupes
Ivan
I
Department of Biology, Queen's University, Kingston, Ontario, Canada K7L 3N6. rupesi@biology.queensu.ca
D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division; D048429:Cell Size / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000254:growth & development*; D013045:Species Specificity
D018797:Cell Cycle Proteins