A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish.
Krx-20, a zinc finger protein, plays an essential role in hindbrain segmentation of vertebrates. Zebrafish gene frb35 encodes a novel zinc finger protein that shares a high homology with Krx-20. The expression domains of frb35 overlap those of krx-20. The expression of frb35 first occurs in the 3rd rhombomere primordium at the onset of segmentation, which is soon followed by expression in the 5th rhombomere. From mid-segmentation onward, the 5th rhombomere has a higher frb35 expression level than the 3rd rhombomere. Unlike krx20, frb35 expression persists in the 5th rhombomere until the end of pharyngula period.
Sun
Zhihui
Z
Department of Biological Sciences and Biotechnology, Protein Science Laboratory of the MOE, Tsinghua University, Beijing 100084, People's Republic of China.
Shi
Kehui
K
Su
Ying
Y
Meng
Anming
A
D000595:Amino Acid Sequence; D000818:Animals; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000737:chemistry*; D051767:Early Growth Response Protein 2; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis* / Q000737:chemistry* / Q000235:genetics; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000096:biosynthesis* / Q000737:chemistry* / Q000235:genetics; D016335:Zinc Fingers
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D051767:Early Growth Response Protein 2; D014157:Transcription Factors; D029961:Zebrafish Proteins; C470834:egr2a protein, zebrafish