Structure and antimicrobial activity of some new norfloxacin and ofloxacin divalent metal ion complexes.
The paper presents the studies of some new complexes of norfloxacin (Nf) and ofloxacin (Of) with Cd(II) and Hg(II). The synthesis, purification and the elemental chemical analysis of the Nf and Of compounds have been performed in order to obtain the chemical formulas. These formulas are confirmed by molecular mass determinations. IR, UV-VIS reflectance spectra were recorded, as well as electric conductometric measurements. These techniques confirm that the obtained compounds are electrolytes and give some hints about their molecular structures. The antimicrobial activity was tested using plates containing Muller-Hinton cultures as well as Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. All compounds and their Nf and Of ligands exert an obvious antimicrobial activity.
Uivarosi
V
V
Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania.
Neagoe
S
S
Aldea
V
V
Niţulescu
A
A
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D002104:Cadmium / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008628:Mercury / Q000494:pharmacology; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015242:Ofloxacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D002104:Cadmium; D015242:Ofloxacin; D008628:Mercury; D009643:Norfloxacin