Angiolymphoid hyperplasia with eosinophilia: a classic clinical presentation with histologic features of angiosarcoma.
BACKGROUND
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease manifested by the proliferation of morphologically distinct endothelial cells.


OBJECTIVE
To illustrate by a case report the clinical and varied histopathologic findings of ALHE.


METHODS
A 29-year-old woman presented with a clinical picture of ALHE but had several histologic features of angiosarcoma.


RESULTS
Management of this patient included repeat biopsies of the lesions, excision of the involved areas, careful histologic examination of the entire specimen, and appropriate follow-up.


CONCLUSIONS
ALHE may present with various histologic features. Knowledge of the spectrum of benign and malignant vascular neoplasms helps manage these challenging cases.
Zeitouni
Nathalie C
NC
Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. zeitouni@roswellpark.org
Hanna
Sameh
S
Loree
Thom R
TR
Brooks
John
J
Cheney
Richard T
RT
D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology; D006801:Humans; D012536:Scalp Dermatoses / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology