Follicular lymphoma with PAS-positive amorphous material: report of two cases.
Extracellular, PAS-positive material has been described in various lymphoproliferative disorders, but is rare in malignant lymphomas. We report two such cases of grade 2 follicular lymphoma that were investigated by routine H&E histology, immunohistochemistry, flow cytometry, and molecular pathology. Ancillary studies confirmed the monoclonality in each case and the antigenic similarity to the neoplastic cells, with the exception of bcL-2. One possible pathogenic mechanism for this extracellular material may be the exocytosis of overproduced cell membranes.
Harris
James
J
Department of Pathology, White Memorial Medical Center, Los Angeles, California, USA.
Cherry
Daniel
D
Lazarchick
John
J
D004396:Coloring Agents; D004801:Eosine Yellowish-(YS); D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008224:Lymphoma, Follicular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008967:Molecular Biology; D010503:Periodic Acid-Schiff Reaction
D004396:Coloring Agents; D005456:Fluorescent Dyes; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin