title: Effect of lithium on dopamine uptake by brain synaptosomes.
abstract: Lithium chloride exerts two opposite effects on dopamine uptake by synaptosomes isolated from rat caudate nucleus. Added in vitro, it inhibits dopamine uptake; whereas administered chronically in vivo, it enhances dopamine uptake in vitro. Thus, in vitro, 1, 2.5, 5 and 10 meqiv.l-1 of lithium chloride decrease [3H]dopamine uptake by 13, 17, 25 and 31%, respectively. Synaptosomes isolated from rats treated with lithium chloride for 20 days, show a 23% increase in [3H]dopamine uptake with respect to synaptosomes isolated from control rats. It is suggested that chronic lithium treatment stimulates a compensatory mechanism which overcomes its direct inhibitory effect on [3H]dopamine uptake.
authors.affiliation: Institute of Pharmacology, University of Cagliari, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Stefanini
authors.forename: A
authors.initials: A
authors.lastname: Argiolas
authors.forename: G L
authors.initials: GL
authors.lastname: Gessa
authors.forename: F
authors.initials: F
authors.lastname: Fadda
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000737:chemistry; D004298:Dopamine / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D007274:Injections, Intraperitoneal; D018021:Lithium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D013574:Synaptosomes / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D013995:Time; D014316:Tritium
chemical_list: D018759:Adrenergic Uptake Inhibitors; D014316:Tritium; D013395:Sucrose; D012110:Reserpine; D018021:Lithium Chloride; D004298:Dopamine