title: Idiopathic scoliosis in families of children with congenital scoliosis.
abstract: Although most cases of congenital scoliosis are thought to be of sporadic etiology, it is not known whether other types of spinal deformity occur in families of individuals with this type of scoliosis. Children with congenital scoliosis were identified through a review of health records and radiographic report databases. Of 237 children with congenital scoliosis investigated, 49 (20.7%) reported a family history of spinal deformity. Detailed pedigrees were done, which showed a history of idiopathic scoliosis in 17.3% of the 237 families. This is a higher than expected rate of spinal deformity in families of children with congenital scoliosis, and the strong association of idiopathic scoliosis in families of children with congenital scoliosis has not been reported previously. Although this finding could be related to the chance occurrence of multiple genetic abnormalities or sporadic events in these families, it does raise the possibility that one genetic defect at least predisposes these families to having different types of spinal deformity develop.
authors.affiliation: Division of Orthopaedic Surgery and Program in Developmental Biology, the Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.
authors.forename: Sheila B
authors.initials: SB
authors.lastname: Purkiss
authors.forename: Brandon
authors.initials: B
authors.lastname: Driscoll
authors.forename: William G
authors.initials: WG
authors.lastname: Cole
authors.forename: Benjamin
authors.initials: B
authors.lastname: Alman
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D012600:Scoliosis / Q000151:congenital* / Q000235:genetics*