Effect of prenatal administration of haloperidol, risperidone, quetiapine and olanzapine on spatial learning and retention in adult rats.
The typical antipsychotic haloperidol and atypical antipsychotics olanzapine, quetiapine and risperidone were administered to pregnant Sprague-Dawley dams in the drinking water from Days 8 to 18 of gestation. When the offspring reached adulthood (2 months), spatial learning and short-term retention were examined using the radial arm maze. Results showed that prenatal administration of haloperidol, risperidone and quetiapine impaired learning but only haloperidol and risperidone disrupted short-term retention.
Rosengarten
Helen
H
Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York 10001, USA. helenrosengarten@nyu.med.edu
Quartermain
David
D
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003987:Dibenzothiazepines / Q000008:administration & dosage* / Q000378:metabolism; D004326:Drinking; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage* / Q000378:metabolism; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D000069348:Quetiapine Fumarate; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000378:metabolism; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology; D018967:Risperidone / Q000008:administration & dosage* / Q000378:metabolism; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D011954:Receptors, Dopamine; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D010890:Pirenzepine; D006220:Haloperidol; D018967:Risperidone; D000077152:Olanzapine