title: seco-Adianane-type triterpenoids from Dorstenia brasiliensis (Moraceae).
abstract: Two seco-adianane-type triterpenoids, dorstenic acid A and B, were isolated, along with a known isopimarane-type diterpenoid and six coumarins, from the roots of Dorstenia brasiliensis. Their structures were elucidated on the basis of their spectral data. The two triterpenoids showed moderate cytotoxicity against leukemia cells (L-1210 and HL-60).
authors.affiliation: College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
authors.forename: Taketo
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Shoji
authors.initials: S
authors.lastname: Hara
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Makino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fujimoto
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C470763:dorstenic acid A; C470762:dorstenic acid B