Comparison of the Growth Promoting Effects of Serum Transferrins from Different Animals on Mouse Mammary Tumor Cell Line GR2H6.
The growth promoting effects of seven animal serum transferrins from mammalian, aves, reptilia, amphibian and osteichthyes on mouse mammary tumor cell line GR2H6 in serum-free medium were compared by MTT assays. The results indicated that the mitogenic activities of the transferrins from different species were different, and this discrepancy was approximately parallel to their binding capacities with transferrin receptors on human placenta and GR2H6 cells.
Shi
Min
M
State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China.
Jing
Nai-He
NH
Feng
You-Min
YM