Brain protection during neurosurgery.
The initial concept of brain protection during neurosurgery is based on research done in the 1970s-1980 which established the concept that by decreasing cerebral metabolic rate the brain could survive longer periods of ischemia. The first section of this chapter reviews some of this initial research that promoted the use of barbiturates for cerebral protection. The second section reviews current anesthetic drugs and their potential for cerebral protection in addition to the benefits of blood pressure, temperature and glucose control. The final section discusses the "new mechanisms of cerebral protection" and the role old and new drugs may play in the future for brain protection during neurosurgery.
Baughman
Verna L
VL
Division of Neuroanesthesiology, Departments of Anesthesiology and Neurosurgery, University of Illinois at Chicago, Suite 3200, 1740 W. Taylor Street (M/C 515), Chicago, IL 60612, USA. vbaughma@uic.edu
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D002560:Cerebrovascular Circulation; D003864:Depression, Chemical; D006801:Humans; D007036:Hypothermia, Induced; D018696:Neuroprotective Agents / Q000627:therapeutic use; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D018377:Neurotransmitter Agents / Q000378:metabolism
D000777:Anesthetics; D001786:Blood Glucose; D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents