An investigation of the ionophoric characteristics of destruxin A.
Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate the potential for destruxin A to form a coordination complex with calcium in which the divalent cation is bound at the center of a sandwich formed by two molecules of destruxin A. This novel calcium ion binding may help explain the diverse biological effects exhibited by the destruxins.
Hinaje
Maria
M
Centre for Molecular Design, University of Portsmouth, Portsmouth, Portsmouth, PO1 2DT, UK.
Ford
Martyn
M
Banting
Lee
L
Arkle
Steve
S
Khambay
Bhupinder
B
D002118:Calcium / Q000378:metabolism; D002412:Cations; D002614:Chelating Agents / Q000494:pharmacology; D047630:Depsipeptides; D007476:Ionophores / Q000494:pharmacology*; D007477:Ions; D008081:Liposomes / Q000378:metabolism; D008956:Models, Chemical; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000494:pharmacology*; D012984:Software; D013997:Time Factors
D002412:Cations; D002614:Chelating Agents; D047630:Depsipeptides; D007476:Ionophores; D007477:Ions; D008081:Liposomes; D010456:Peptides, Cyclic; C040423:destruxin A; D002118:Calcium