Corneal ulcer caused by the new fungal species Sarcopodium oculorum.
We describe a case of keratitis caused by a new species of the hyphomycetous genus Sarcopodium, S. oculorum. The corneal ulcer developed after 5 months of treatment with corticosteroids in a Brazilian boy diagnosed with allergic conjunctivitis. Fungal hyphae and conidia were detected in corneal scrapings, and repeated cultures were positive for this fungus. The infection was resolved with natamycin and ketoconazole. Eleven antifungals were tested against this fungus, and all except flucytosine and fluconazole showed in vitro activity.
Guarro
Josep
J
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, 43201 Reus, Tarragona, Spain. umb@fmcs.urv.es
Höfling-Lima
Ana Luisa
AL
Gené
Josepa
J
De Freitas
Denise
D
Godoy
Patricio
P
Zorat-Yu
Maria Luisa
ML
Zaror
Luis
L
Fischman
Olga
O
D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D003320:Corneal Ulcer / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000382:microbiology*; D006801:Humans; D007634:Keratitis / Q000382:microbiology; D007654:Ketoconazole / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000145:classification* / Q000302:isolation & purification*; D009181:Mycoses / Q000382:microbiology*; D010866:Natamycin / Q000494:pharmacology / Q000627:therapeutic use
D000935:Antifungal Agents; D010866:Natamycin; D007654:Ketoconazole