title: Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.
abstract: The importance of CD8 T cells in the pathogenesis of organ-specific autoimmune diseases has not previously been well recognized. Recent evidence, however, indicates that autoreactive CD8 T cells can contribute substantially to tissue damage in both murine and human autoimmune disorders. As such, these T cells now become an attractive target for therapeutic intervention.
authors.affiliation: INSERM U563 and Immunology Laboratory, Toulouse University Hospital, France.
authors.forename: Roland S
authors.initials: RS
authors.lastname: Liblau
authors.forename: F Susan
authors.initials: FS
authors.lastname: Wong
authors.forename: Lennart T
authors.initials: LT
authors.lastname: Mars
authors.forename: Pere
authors.initials: P
authors.lastname: Santamaria
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D015551:Autoimmunity; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016503:Drug Delivery Systems; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D009928:Organ Specificity