Processing emotional information in Alzheimer's disease: effects on memory performance and neurophysiological correlates.
BACKGROUND
There is some impairment of the ability of patients with Alzheimer's disease (AD) to perceive emotions, but this ability seems relatively preserved compared to the impairment of other cognitive domains. Few studies have focused on the link between emotional processing and other cognitive functions, such as memory or attention.


OBJECTIVE
This study was designed to investigate whether the emotional content of a text can influence memory in patients affected by AD and whether this effect is related to attentional processes as measured by event-related potentials (ERP).


METHODS
All subjects were administered neuropsychological tests and a logical memory test including emotional and nonemotional material. ERP were recorded during an attention task.


RESULTS
AD patients had better immediate recall of sad and, to a lesser extent, happy stories than of neutral stories. This difference also affected multiple choice recognition and identification (immediate and delayed) of emotional content. The amplitude of both P300 and mismatch negativity was significantly decreased in the group as a whole. There was no correlation between P300 parameters and performance on the memory tasks, whatever their emotional content.


CONCLUSIONS
The results show relatively preserved emotional processing in patients with AD and suggest that the emotional content of a context can influence memory performance. We found no evidence that this effect is mediated by attention as measured by ERP.
Boller
François
F
Unité 324 INSERM, Centre Paul Broca, Paris, France. boller@broca.inserm.fr
El Massioui
Farid
F
Devouche
Emanuel
E
Traykov
Latchezar
L
Pomati
Simone
S
Starkstein
Sergio E
SE
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology*; D001288:Attention / Q000502:physiology; D001519:Behavior; D004644:Emotions; D018913:Event-Related Potentials, P300; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008606:Mental Processes; D011939:Mental Recall; D009420:Nervous System / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011795:Surveys and Questionnaires; D013997:Time Factors