title: Mesial temporal lobe Cho to Cr(PCr) ratio asymmetry in chronic schizophrenics.
abstract: Proton magnetic resonance spectra (MRS) were acquired from 1.5 x 1.5 x 1.5-cm voxels in the left and right mesial temporal lobes of 20 schizophrenic patients and 20 non-psychiatric comparison subjects. Choline (Cho) to creatine (and phosphocreatine) (Cr(PCr)) ratios were estimated as were the percent gray matter, white matter and CSF contributing to the voxel. The Cho/Cr(PCr) metabolite ratio was significantly lower in the left temporal lobe than in the right temporal lobe for both the schizophrenia subjects and control group. This difference was greater in the schizophrenia subjects. Left temporal lobe gray matter voxel content was significantly higher and white matter content was significantly lower than in the right temporal lobe for both the schizophrenia subjects and control group. This difference was the same for the schizophrenia subjects and control group. Left voxel gray matter and white matter content correlated with Cho/Cr(PCr) metabolite ratios for the schizophrenic subjects but not for the control subjects. No such correlations were noted on the right side. No significant difference was found between Cho/Cr(PCr) in the left temporal lobe or in the right temporal lobe of the schizophrenia subjects vs. the control group.
authors.affiliation: Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. const@mclean.harvard.edu
authors.forename: Constance M
authors.initials: CM
authors.lastname: Moore
authors.forename: Christina M
authors.initials: CM
authors.lastname: Bonello
authors.forename: Andrea R
authors.initials: AR
authors.lastname: Sherwood
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Cohen
authors.forename: Perry F
authors.initials: PF
authors.lastname: Renshaw
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Yurgulen-Todd
mesh_terms: D000328:Adult; D002794:Choline / Q000378:metabolism*; D002908:Chronic Disease; D003401:Creatine / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology; D013702:Temporal Lobe / Q000378:metabolism* / Q000473:pathology
chemical_list: D010725:Phosphocreatine; D003401:Creatine; D002794:Choline