Strain improvement studies for cephalosporin C production by Cephalosporium acremonium.
Treatment of spore suspension of Cephalosporium acremonium ATCC 48272 with UV rays and N-methyl-N-nitro-N-nitrosoguanidine (NTG) induced mutants capable of producing higher yields of cephalosporin C. Antibiotic yield was improved from 630 micrograms/ml to 1995 micrograms/ml of the broth resulting in a high yielding mutant.
Ellaiah
P
P
Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India. adikunamneni@rediffmail.com
Adinarayana
K
K
Chand
G Murali
GM
Subramanyam
G S V
GS
Srinivasulu
B
B
D000164:Acremonium / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D002511:Cephalosporins / Q000096:biosynthesis*; D005285:Fermentation; D009153:Mutagens / Q000494:pharmacology; D014466:Ultraviolet Rays
D002511:Cephalosporins; D009153:Mutagens; C025163:cephalosporin C