title: Lymphoma immunophenotyping: "borderline" lymphomas.
abstract: Immunophenotyping of B-cell lymphoproliferative disorders is indispensable, especially in disorders with CD19(+) CD5(+) B lymphocytes, where we have to make the distinction between low grade neoplasia, such as chronic lymphocytic leukemia with CD23(+) malignant lymphocytes, and aggressive neoplasia such as mantle cell lymphoma with CD23(-) malignant lymphocytes. We found some cases of CD19(+) CD5(+) lymphoproliferative disorders that do not meet all criteria for diagnosis of chronic lymphocytic leukemia or mantle cell lymphoma. For instance, we found cases with a low or no expression of CD23, asociated with absence of expression of FMC7 and surface immunoglobulins. These cases could be classified as "borderline" CD19(+) CD5(+) B cell lymphoproliferative disorders, with an intermediate neoplasic grade.
authors.affiliation: Department of Hematology, "Coltea" Clinical Hospital, "Carol Davila" University of Medicine, 1, I.C. Bratianu Blvd., 70453 Bucharest, Romania. teammut@cmb.ro
authors.forename: Delia
authors.initials: D
authors.lastname: Mut-Popescu
authors.forename: Anca
authors.initials: A
authors.lastname: Lupu
authors.forename: H.
authors.initials: H
authors.lastname: Bumbea
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Vladareanu
authors.forename: Doina
authors.initials: D
authors.lastname: Barbu
authors.forename: Silvana
authors.initials: S
authors.lastname: Angelescu
authors.forename: Nicoleta
authors.initials: N
authors.lastname: Olteanu
authors.forename: A.
authors.initials: A
authors.lastname: Colita