title: Moyamoya disease and Down syndrome: case report and review of the literature.
abstract: We present the case of a 29-year-old woman with Down syndrome who developed bilateral frontal ischemic stroke. Cerebral angiography demonstrated an occlusion of the both supraclinoid internal carotid arteries associated with dilated collateral vessels, consistent with moyamoya disease. We review the clinical and radiological features of moyamoya disease associated with Down syndrome and discuss a few major physiopathologic hypotheses to explain this association.
authors.affiliation: Centre Neurologique William Lennox, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels.
authors.forename: Valérie
authors.initials: V
authors.lastname: de Borchgrave
authors.forename: Françoise
authors.initials: F
authors.lastname: Saussu
authors.forename: Anne
authors.initials: A
authors.lastname: Depre
authors.forename: Thierry
authors.initials: T
authors.lastname: de Barsy
mesh_terms: D000328:Adult; D016893:Carotid Stenosis / Q000000981:diagnostic imaging; D002533:Cerebral Angiography / Q000706:statistics & numerical data; D004314:Down Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D009072:Moyamoya Disease / Q000150:complications* / Q000000981:diagnostic imaging