title: [Activation of key proenzymes of the blood coagulation system by the fibrin E fragment].
abstract: Plasminogen and prothrombin are key proenzymes of fibrinolytic and clotting system. It is known that they can be activated by indirect activators streptokinase and staphylocoagulase. In this paper it is shown that fibrin E fragment purified from DD-E complex induced catalytic activity in plasminogen and clotting activity in prothrombin. Streptokinase increased 2 times the rate of catalytic activity induction by E fragment in prothrombin. It's possibly that process is one of the factors providing for rethrombosis after thrombolytic therapy of myocardial infarction.
authors.affiliation: Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
authors.forename: T M
authors.initials: TM
authors.lastname: Platonova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Slomins'kyĭ
authors.forename: T M
authors.initials: TM
authors.lastname: Chernyshenko
authors.forename: Ie M
authors.initials: IeM
authors.lastname: Makohonenko
mesh_terms: D001779:Blood Coagulation Factors / Q000378:metabolism*; D002384:Catalysis; D003030:Coagulase / Q000378:metabolism; D004792:Enzyme Precursors / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D013300:Streptokinase / Q000378:metabolism; D015912:Thrombolytic Therapy
chemical_list: D001779:Blood Coagulation Factors; D003030:Coagulase; D004792:Enzyme Precursors; D005338:Fibrin Fibrinogen Degradation Products; D013300:Streptokinase