title: Airway assessment by volumetric computed tomography in snorers and subjects with obstructive sleep apnea in a Far-East Asian population (Chinese).
abstract: OBJECTIVE
  To evaluate the airway dimension of simple snorers and subjects with obstructive sleep apnea (OSA) in a Far-East Asian population (Chinese).
  
  
  METHODS
  Prospective study of 117 near-consecutive patients evaluated for snoring and possible OSA from January 1998 to December 1998 in a sleep laboratory. Overnight polysomnography (PSG) was performed on all patients and the sleep parameters, including respiratory disturbance index (RDI), snoring index, minimal oxygen saturation (min O2), percentage of slow wave sleep (SWS), and rapid eye movement (REM) were recorded. Three-dimensional computerized tomography (CT) during awake periods was performed. The anteroposterior (AP) and the lateral distance of the retropalatal (RP) region in the oropharynx, the smallest area of RP, and retroglossal (RG) regions, and the total volume of the oropharynx were measured.
  
  
  RESULTS
  Ninety-eight patients were diagnosed with OSA (mean RDI, 41.48 +/- 26.45 events per hour; min O2, 72.82 +/- 12.86%), whereas 19 were simple snorers. The AP and the lateral distance of the RP region, as well as the smallest area of the RP region, are significantly smaller in subjects with OSA. However, no differences in the RG region and the total volume of the oropharynx were found between the two groups. Linear regression analysis demonstrated that the lateral dimension and the smallest RP area in overweight subjects inversely correlated with the RDI, but only the AP dimension of the RP area was found to have an inverse correlation with the RDI in the underweight subjects.
  
  
  CONCLUSIONS
  In Far-East Asians (Chinese), the RP airway was found to be the primary site of narrowing in subjects with OSA, and the narrowest RP area was inversely correlated with RDI. Furthermore, weight may influence the pattern of RP narrowing by contributing to lateral collapse.
authors.affiliation: Sleep Center, Department of Otolaryngology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Ning-Hung
authors.initials: NH
authors.lastname: Chen
authors.forename: Kasey K
authors.initials: KK
authors.lastname: Li
authors.forename: Shia-Yu
authors.initials: SY
authors.lastname: Li
authors.forename: Chao-Reng
authors.initials: CR
authors.lastname: Wong
authors.forename: Ming-Lung
authors.initials: ML
authors.lastname: Chuang
authors.forename: Chung-Chi
authors.initials: CC
authors.lastname: Hwang
authors.forename: Yao-Kaung
authors.initials: YK
authors.lastname: Wu
mesh_terms: D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009960:Oropharynx / Q000000981:diagnostic imaging*; D017286:Polysomnography; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000000981:diagnostic imaging / Q000208:ethnology*; D012913:Snoring / Q000000981:diagnostic imaging / Q000208:ethnology*; D013624:Taiwan; D014057:Tomography, X-Ray Computed / Q000379:methods