Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
He
Weidong
W
Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, Belgium.
Cik
Miroslav
M
Van Puyvelde
Luc
L
Van Dun
Jacky
J
Appendino
Giovanni
G
Lesage
Anne
A
Van der Lindin
Ilse
I
Leysen
Josée E
JE
Wouters
Walter
W
Mathenge
Simon G
SG
Mudida
Francis P
FP
De Kimpe
Norbert
N
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008958:Models, Molecular; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029645:Thymelaeaceae / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D009414:Nerve Growth Factors; D013729:Terpenes; D014315:Triterpenes; C417923:kirkinine; C011309:mezerein