title: Efficient delivery of siRNA for inhibition of gene expression in postnatal mice.
abstract: It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs.
authors.affiliation: Mirus Corporation, 505 South Rosa Road, Madison, Wisconsin 53719, USA. davel@genetransfer.com
authors.forename: David L
authors.initials: DL
authors.lastname: Lewis
authors.forename: James E
authors.initials: JE
authors.lastname: Hagstrom
authors.forename: Aaron G
authors.initials: AG
authors.lastname: Loomis
authors.forename: Jon A
authors.initials: JA
authors.lastname: Wolff
authors.forename: Hans
authors.initials: H
authors.lastname: Herweijer
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003063:Cnidaria; D001517:Coleoptera; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D049452:Green Fluorescent Proteins; D008099:Liver / Q000378:metabolism; D008156:Luciferases / Q000235:genetics; D008164:Luminescent Proteins / Q000235:genetics; D051379:Mice; D010957:Plasmids; D034741:RNA, Small Interfering; D022661:RNA, Untranslated / Q000008:administration & dosage*; D019076:Transgenes
chemical_list: D008164:Luminescent Proteins; D034741:RNA, Small Interfering; D022661:RNA, Untranslated; D049452:Green Fluorescent Proteins; D008156:Luciferases