title: Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer.
abstract: A pivotal study reveals a long-sought-after mechanism for gene amplification and provides important implications for oncogenesis.
authors.affiliation: Department of Pathology, UCSF Comprehensive Cancer Center, University of California at San Francisco, 94143, USA. ttlsty@itsa.ucsf.edu
authors.forename: Thea D
authors.initials: TD
authors.lastname: Tlsty
mesh_terms: D016923:Cell Death / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D005784:Gene Amplification; D016158:Genes, p53; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D011995:Recombination, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: Non-programmatic