title: Recruiting volunteers for a multisite phase I/II HIV preventive vaccine trial in Thailand.
abstract: Factors believed to be predictive of retention through the recruitment and screening processes for preventive HIV trials were investigated in a large multisite phase I/II HIV vaccine trial in Thailand. Retention through recruitment was equal to or greater than in previous smaller trials with similar populations. The data suggested that recruitment proceeded in a stepwise manner with different influences at each step. Demographic and motivational variables were most important in predicting retention in making and keeping screening appointments. Altruistic or mixed altruistic and nonaltruistic motives were associated with greater retention. Laboratory/medical variables appeared to be the main influence on retention during screening, although some volunteers withdrew for different reasons. The frequent presence of mixed (altruistic and nonaltruistic) motives at initial contact suggests that motivation for trials is more complex than has been previously acknowledged.
authors.affiliation: Faculty of Nursing and Research Institute of Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Darawan
authors.initials: D
authors.lastname: Thapinta
authors.forename: Richard A
authors.initials: RA
authors.lastname: Jenkins
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Morgan
authors.forename: Joseph
authors.initials: J
authors.lastname: Chiu
authors.forename: Wantanee
authors.initials: W
authors.lastname: Boenim
authors.forename: Valai
authors.initials: V
authors.lastname: Bussaratid
authors.forename: Catherine
authors.initials: C
authors.lastname: Chaddic
authors.forename: Supa
authors.initials: S
authors.lastname: Naksrisook
authors.forename: Benjaluck
authors.initials: B
authors.lastname: Phonrat
authors.forename: Nampueng
authors.initials: N
authors.lastname: Sirijongdee
authors.forename: Pornchai
authors.initials: P
authors.lastname: Sornsathapornkul
authors.forename: Auchara
authors.initials: A
authors.lastname: Sontirat
authors.forename: Prasong
authors.initials: P
authors.lastname: Srisaengchai
authors.forename: Chanmet
authors.initials: C
authors.lastname: Suwanarach
authors.forename: Siriluck
authors.initials: S
authors.lastname: Wongkamhaeng
authors.forename: Arthur E
authors.initials: AE
authors.lastname: Brown
authors.forename: Chirasak
authors.initials: C
authors.lastname: Khamboonruang
authors.forename: Sorachai
authors.initials: S
authors.lastname: Nitayaphan
authors.forename: Punnee
authors.initials: P
authors.lastname: Pitisuttithum
authors.forename: Prasert
authors.initials: P
authors.lastname: Thongchareon
mesh_terms: D016915:AIDS Vaccines; D000328:Adult; D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D017322:Clinical Trials, Phase II as Topic / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic / Q000379:methods*; D018579:Patient Selection; D013785:Thailand
chemical_list: D016915:AIDS Vaccines