title: Recurrent pneumococcal meningitis in homozygous C3 deficiency.
abstract: Congenital deficiencies of complement system proteins are rare. A 4-year-old girl was admitted for meningitis. She had had repeated attacks of pneumococcal meningitis and otitis media at the age of 3 years. Analysis of cerebrospinal fluid showed that this meningitis was due to pneumococcal infection. Complement 3 and CH50 values of the proband and her brother were low, while her parents were normal. The patient was given polyvalent pneumococcal and anti-haemophilus vaccines plus ceftriaxone. Recovery was complete after 15 days of antibiotic therapy. This is the first description of a case of recurrent meningitis with C3 and CH50 deficiency in a Turkish family.
authors.affiliation: Department of Pediatrics, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey. mtotan@omu.edu.tr
authors.forename: Mehmet
authors.initials: M
authors.lastname: Totan
mesh_terms: D002675:Child, Preschool; D003176:Complement C3 / Q000172:deficiency*; D015941:Complement Hemolytic Activity Assay; D005260:Female; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000276:immunology*; D012008:Recurrence; D014421:Turkey
chemical_list: D003176:Complement C3