title: Dancing with the host; flow-dependent bacterial adhesion.
abstract: Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flow of blood over endothelium or mucous over the surface of the epithelium.
authors.affiliation: Howard Hughes Medical Institute, Boston, MA 02111, USA. ralph.isberg@tufts.edu
authors.forename: Ralph R
authors.initials: RR
authors.lastname: Isberg
authors.forename: Penelope
authors.initials: P
authors.lastname: Barnes
mesh_terms: D018829:Adhesins, Bacterial / Q000378:metabolism*; D018830:Adhesins, Escherichia coli; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D036781:Fimbriae Proteins; D010861:Fimbriae, Bacterial / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology; D012212:Rheology
chemical_list: D018829:Adhesins, Bacterial; D018830:Adhesins, Escherichia coli; D011956:Receptors, Cell Surface; C058769:fimH protein, E coli; D036781:Fimbriae Proteins