Prognostic factors of gastrointestinal stromal tumors.
Gastrointestinal stromal tumors (GIST) are rare neoplasms of unknown etiology and pathogenesis. Their clinical behavior is very unpredictable and a reliable prognostic factor is lacking. The aim of this study was to analyze some prognostic factors and estimate which one is the most reliable. Thirty-eight biopsy specimens of GIST were immunolabeled for PCNA, CD34, vimentin, NSE and actin. The greatest diameter, histological grading, mitotic count, DNA-index and S-phase were estimated for each case. All patients were followed-up for at least 24 months or to death. The data were analysed by univariate and multivariate statistical analysis using a computer program. The results showed that greatest diameter, tumor grade, mitotic count and PCNA-index are prognostic factors in univariate analysis. In multivariate analysis only the greatest diameter is a useful prognostic factor for planning further therapy.
Kovac
Drazen
D
Department of Pathology, Rijeka University School of Medicine, Croatia. drazen.kovac@medri.hr
Petrovecki
Mladen
M
Jasic
Mladen
M
Dobi-Babic
Renata
R
Ivanis
Nikola
N
Rubinic
Milivoj
M
Krizanac
Simun
S
Jonjic
Nives
N
Rizzardi
Clara
C
Melato
Mauro
M
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D015996:Survival Rate; D014746:Vimentin / Q000096:biosynthesis
D014746:Vimentin