Paraneoplastic cerebellar degeneration and nephrotic syndrome preceding Hodgkin's disease: case report and review of the literature.
A patient presented with symptoms of cerebellar degeneration and nephrotic syndrome. A work-up at that time failed to reveal an underlying disease; however, 20 months later Hodgkin's disease was diagnosed. Hodgkin's lymphadenopathy developed 2 wk after prednisone therapy for the nephrotic syndrome had been discontinued. Systemic polychemotherapy resulted in complete remission of both Hodgkin's disease and nephrotic syndrome, while the neurological deficit persisted. Patients with unexplained cerebellar degeneration and/or nephrotic syndrome demand extensive evaluation for the presence of Hodgkin's disease, and steroid therapy may delay diagnosis.
Spyridonidis
A
A
Departmentof Hematology/Oncology, University Medical Center Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany.
Fischer
K-G
KG
Glocker
F X
FX
Fetscher
S
S
Klisch
J
J
Behringer
D
D
D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use; D000328:Adult; D020234:Gait Ataxia / Q000209:etiology; D006689:Hodgkin Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013997:Time Factors
D000305:Adrenal Cortex Hormones