Expression of metastasis suppressor gene (KAI1/CD82) in oral squamous cell carcinoma and its clinico-pathological significance.
In this study, we investigated the expression of the KAI1/CD82 gene in oral squamous cell carcinoma (oral SCC). We studied 43 oral SCC patients. Reverse transcription-polymerase chain reaction (RT-PCR) analysis was performed to evaluate expression of this gene, and results were compared to the clinico-pathological findings. Twenty-five specimens (58.1%) were KAI1/CD82-positive, and 18 (41.9%) were negative. There were statistically significant relationships between gene expression and both histological malignancy (P=0.0205) and mode of invasion (P=0.0315). But there were no correlations of expression with tumor status, regional lymph node metastasis, pathological lymph node metastasis or histological differentiation. No significant relationship was observed between patient survival and expression of KAI1/CD82 by tumors. The results of this study suggest that the KAI1/CD82 gene may not be a useful predictor of prognosis, although decreased gene expression may be associated with increased invasive ability of oral SCC.
Imai
Y
Y
Department of Oral and Maxillofacial Surgery, Dokkyo University School of Medicine, 880 Kita-kobayashi, Mibu, Tochigi, Japan. yimai@dokkyomed.ac.jp
Sasaki
T
T
Shinagawa
Y
Y
Akimoto
K
K
Fujibayashi
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051861:Kangai-1 Protein; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011518:Proto-Oncogene Proteins; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate
D015703:Antigens, CD; D014408:Biomarkers, Tumor; C497688:CD82 protein, human; D018076:DNA, Complementary; D004273:DNA, Neoplasm; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins