[The changes of bispectral index induced by administration of midazolam during propofol anesthesia].
The effect of the additional administration of midazolam or flumazenil on bispectral index (BIS) during propofol anesthesia was investigated in 22 scheduled surgical patients. Midazolam 10 or 30 micrograms.kg-1, or flumazenil 6 or 12 micrograms.kg-1 was injected to the patients to evaluate their effect on BIS after achieving steady state of hypnosis more than 1 hr of propofol anesthesia with 5 mg.kg-1.hr-1. The only midazolam 30 micrograms.kg-1 significantly reduced BIS value from 47.8 +/- 8.6 to 36.8 +/- 6.5. The synergistic interaction between midazolam and propofol assessed by BIS might be less clear than that assessed by hypnotic dose of propofol using psychopharmacological investigation.
Satomoto
Maiko
M
Medical Corps, 1st Air Wing, Japan Air Self Defense Force, Hamamatsu 432-8551.
Aoki
Hiroshi
H
Yamada
Shigeyuki
S
Umeda
Eiichiro
E
Adachi
Yushi
Y
Higuchi
Hideyuki
H
Watanabe
Kazuhiko
K
Satoh
Tetsuo
T
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000494:pharmacology*; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D006801:Humans; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D015742:Propofol; D013514:Surgical Procedures, Operative
D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D008874:Midazolam; D015742:Propofol