title: ent-trachyloban-3beta-ol, a new cytotoxic diterpene from Croton zambesicus.
abstract: The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 microg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.
authors.forename: S
authors.initials: S
authors.lastname: Block
authors.forename: C
authors.initials: C
authors.lastname: Stévigny
authors.forename: M-C
authors.initials: MC
authors.lastname: De Pauw-Gillet
authors.forename: E
authors.initials: E
authors.lastname: de Hoffmann
authors.forename: G
authors.initials: G
authors.lastname: Llabrès
authors.forename: V
authors.initials: V
authors.lastname: Adjakidjé
authors.forename: J
authors.initials: J
authors.lastname: Quetin-Leclercq
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C464952:trachyloban-3-ol