title: Short-term effect of nasal intermittent positive-pressure ventilation in patients with restrictive thoracic disease.
abstract: BACKGROUND
  The use of nasal intermittent positive pressure ventilation (NIPPV) would be expected to ameliorate dyspnea, ventilatory capacity and exercise tolerance durability in individuals with hypercapnic respiratory failure secondary to restrictive thoracic disease.
  
  
  OBJECTIVE
  The purpose of this study was to determine the short-term effect of NIPPV on respiratory muscle endurance, exercise capacity and respiratory functions in patients with chronic respiratory failure due to restrictive thoracic disease.
  
  
  METHODS
  Twelve patients with chronic ventilatory failure due to restrictive thoracic disease underwent nasal bilevel positive airway pressure (BiPAP) ventilation for 2 h a day during 15 consecutive days. The effects were assessed by spirometry, arterial blood gas analysis, 6-min walking test, sensation of dyspnea according to the American Thoracic Society dyspnea scoring scales (ATS) and surface electromyogram of the diaphragm (EMGdi) before and after the study (on day 15).
  
  
  RESULTS
  Nasal BiPAP reduced the ATS dyspnea score from 2.5 +/- 0.9 to 1.6 +/- 0.4 (p < 0.01). Distances walked in 6 min increased from 320.66 +/- 93.56 to 382.41 +/- 121.20 m (p < 0.05). Comparison of baseline with levels after nasal BiPAP ventilation showed a statistically significant improvement in PaCO(2) (p < 0.05). Forced vital capacity increased from 35 to 50% of the predicted value (p < 0.01). There were no statistically significant reductions in the amplitude of EMGdi after the therapy.
  
  
  CONCLUSIONS
  These results indicate that NIPPV delivered via nasal BiPAP improves respiratory functions, exercise capacity, and reduces dyspnea in the short term in patients with chronic respiratory failure due to restrictive thoracic disease. Whether such short-term improvements can be sustained merits further study.
authors.affiliation: Atatürk Chest Diseases and Chest Surgery Center, Kirikkale Medical University, Kirikkale, Turkey. pinarerg@hotmail.com
authors.forename: Pinar
authors.initials: P
authors.lastname: Ergün
authors.forename: Gülümser
authors.initials: G
authors.lastname: Aydin
authors.forename: Ulkü Yilmaz
authors.initials: UY
authors.lastname: Turay
authors.forename: Yurdanur
authors.initials: Y
authors.lastname: Erdoğan
authors.forename: Atalay
authors.initials: A
authors.lastname: Cağlar
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Biber
mesh_terms: D000368:Aged; D002908:Chronic Disease; D004576:Electromyography; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D007738:Kyphosis / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D012132:Respiratory Muscles / Q000503:physiopathology; D012600:Scoliosis / Q000150:complications / Q000503:physiopathology; D016896:Treatment Outcome; D014797:Vital Capacity