title: Valproate-associated dysmyelopoiesis in elderly patients.
abstract: Sodium valproate is widely prescribed for patients with epilepsy and psychiatric disorders. Hematologic toxic effects have been largely described in pediatric patients, and dysmyelopoiesis is reported rarely. We describe 2 elderly patients with valproate-associated dysmyelopoiesis and postulate that this particular side effect may be much more common than currently recognized. A correct diagnosis is important for acute patient anagement and for prognostication.
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
authors.forename: Chi-chiu
authors.initials: CC
authors.lastname: So
authors.forename: Kit-fai
authors.initials: KF
authors.lastname: Wong
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced* / Q000473:pathology; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid