The effect of fluoride and hypothermia on the in vitro metabolism of mivacurium.
The fluoride inhibition of mivacurium hydrolysis by pseudocholinesterase increases in hypothermia, but it will very rarely occur in clinical practice because it requires rather large fluoride concentrations (>50 micromol/L) and very low temperatures (<28 degrees C).
Gruber
Michael
M
Department of Anesthesiology, University of Regensburg, Regensburg, Germany. michael.gruber@klinik.uni-regensburg.de
Lindner
Regina
R
Prasser
Christopher
C
Wiesner
Gunther
G
D000328:Adult; D002091:Butyrylcholinesterase / Q000097:blood / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007036:Hypothermia, Induced; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D000077590:Mivacurium; D003473:Neuromuscular Nondepolarizing Agents / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002091:Butyrylcholinesterase; D005459:Fluorides