Indinavir-induced cholelithiasis in a patient infected with human immunodeficiency virus.
We report the first case of acute cholecystitis due to indinavir-induced cholelithiasis in a patient infected with human immunodeficiency virus who had been receiving indinavir for 56 months. Infrared spectroscopy demonstrated that the gallstone was composed of indinavir monohydrate (50%), calcium bilirubinate (28%), calcium palmitate (10%), cholesterol (7%), and proteins (5%). The role of high-level chronic unconjugated hyperbilirubinemia coupled with high blood concentrations of indinavir is discussed.
Verdon
Renaud
R
Unité de Maladies Infectieuses, Centre Hospitalier Universitaire Côte-de-Nacre, 14033 Caen, France. verdon-r@chu-caen.fr
Daudon
Michel
M
Albessard
Françoise
F
Brefort
Jean-Louis
JL
Bazin
Claude
C
D000208:Acute Disease; D000328:Adult; D001663:Bilirubin / Q000032:analysis; D002769:Cholelithiasis / Q000139:chemically induced* / Q000737:chemistry; D002784:Cholesterol / Q000032:analysis; D015658:HIV Infections / Q000150:complications*; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D019469:Indinavir / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D019308:Palmitic Acid / Q000032:analysis
D017320:HIV Protease Inhibitors; D019308:Palmitic Acid; D019469:Indinavir; D002784:Cholesterol; D001663:Bilirubin