title: Expression of CD4 on peripheral blood granulocytes. a novel finding in a case of myelodysplastic syndrome in association with t(5;12).
abstract: Myelodysplastic syndromes (MDS) are associated with cell maturation defects that can manifest as abnormal surface antigen expression. We describe a patient with refractory anemia with excess blasts, who presented with infection and extensive dysplastic features in peripheral blood granulocytes. The granulocytes expressed CD11b, CD13, CD15, CD33, and CD43. The granulocytes also expressed CD4 antigen. Cytogenetic analysis showed a clonal t(5;12)(q33;p13). The patient improved on antibiotics with partial improvement in the dysplastic features. However, shortly after, the patient experienced paravertebral extramedullary blast transformation followed by a leukemia phase of acute monoblastic leukemia. The patient died a few days later. This is the first report describing anomalous expression of CD4 on granulocytes in MDS. Since the breakpoint on chromosome 12 is near the CD4 gene, which is mapped to 12p12, we hypothesize that dysregulation of the CD4 gene may have occurred resulting in its persistent expression on mature and maturing granulocytes.
authors.affiliation: Department of Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, USA.
authors.forename: M Tarek
authors.initials: MT
authors.lastname: Elghetany
authors.forename: Claudia P
authors.initials: CP
authors.lastname: Molina
authors.forename: Jyoti
authors.initials: J
authors.lastname: Patel
authors.forename: Joe
authors.initials: J
authors.lastname: Martinez
authors.forename: Hanna
authors.initials: H
authors.lastname: Schwab
authors.forename: Gopalrao V N
authors.initials: GV
authors.lastname: Velagaleti
mesh_terms: D015704:CD4 Antigens / Q000096:biosynthesis*; D002881:Chromosomes, Human, Pair 12; D002895:Chromosomes, Human, Pair 5; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D015704:CD4 Antigens