title: Magnetic resonance imaging in breast cancer recurrence.
abstract: OBJECTIVE
  To determine the sensitivity, specificity and accuracy of magnetic resonance imaging (MRI) in detecting breast cancer recurrence.
  
  
  METHODS
  Forty women conservatively treated for breast cancer underwent MRI and confirmation on histology and cytology of suspected local recurrence. In these patients both clinical and mammographic/ultrasound features of local recurrence were nonspecific or suspicious. All patients were examined at least 1 year after completion of radiation treatment. Dynamic magnetic resonance imaging was performed with a 1.5 T unit using a dedicated bilateral breast coil. Qualitative and quantitative data were obtained. Statistical analysis was also performed with the Student T-test.
  
  
  RESULTS
  Breast cancer recurrence was confirmed on histology in 22 patients. MRI identified all the 22 breast recurrent cancers. False-positive contrast enhancement was seen in only two patients. In four patients recurrence was classified as multifocal. In one patient the tumor was detected in the contralateral breast. MRI showed 95% accuracy, 100% sensitivity, 88.8% specificity with 5% false-positives and 100% negative predictive value.
  
  
  CONCLUSIONS
  Dynamic MRI appears a valuable technique for differentiation of post-treatment changes from recurrent carcinoma and for guiding the histological confirmation. Its high negative predictive value may have an impact on follow-up of treated breast.
authors.affiliation: Department of Radiology, Università Cattolica Del Sacro Cuore, Rome, Italy. belli.paolo@tiscalinet.it
authors.forename: P
authors.initials: P
authors.lastname: Belli
authors.forename: M
authors.initials: M
authors.lastname: Costantini
authors.forename: M
authors.initials: M
authors.lastname: Romani
authors.forename: P
authors.initials: P
authors.lastname: Marano
authors.forename: G
authors.initials: G
authors.lastname: Pastore
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity