Intravenous verapamil blunts hyperdynamic responses during electroconvulsive therapy without altering seizure activity.
A dose of 0.1 mg/kg of verapamil, administered immediately before anesthesia, significantly reduces the increase in peak heart rate and mean arterial blood pressure after electroconvulsive therapy. Furthermore, the administration of verapamil does not reduce the duration of the seizure.
Wajima
Zen'ichiro
Z
Department of Anesthesia, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan. HFB01245@nifty.com
Yoshikawa
Tatsusuke
T
Ogura
Akira
A
Imanaga
Kazuyuki
K
Shiga
Toshiya
T
Inoue
Tetsuo
T
Ogawa
Ryo
R
D000328:Adult; D000368:Aged; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000503:physiopathology; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D014700:Verapamil