Effects of antibiotics on reactive oxygen species generation by neutrophils.
Antibiotic therapy of patients with exacerbation of chronic obstructive bronchitis exposed and not exposed to ozone did not improve oxidative metabolism in neutrophils. Cefazolin, ceftizoxime, and gentamicin normalized functional biocidal reserves of neutrophils, which correlated with pronounced therapeutic effects.
Abdrashitova
N F
NF
Russian State Medical University, Moscow.
Romanov
Y A
YA
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D029481:Bronchitis, Chronic / Q000097:blood; D002437:Cefazolin / Q000494:pharmacology; D015296:Ceftizoxime / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007221:Industry; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D016273:Occupational Exposure; D010100:Oxygen / Q000378:metabolism; D010126:Ozone; D010406:Penicillins / Q000494:pharmacology; D017382:Reactive Oxygen Species
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D017382:Reactive Oxygen Species; D010126:Ozone; D000667:Ampicillin; D015296:Ceftizoxime; D002437:Cefazolin; D010100:Oxygen