The telencephalon saved by TLC.
The telencephalon is one of the most complex parts of the brain, and its patterning is still poorly understood. In this issue of Neuron, describe a novel Wnt antagonist Tlc, a member of the secreted Frizzled-related protein (sFrp) family. Secreted from the anterior boundary of the zebrafish neural plate, Tlc appears to protect the telencephalon from obliteration by a more caudal neural Wnt signal.
Grove
Elizabeth
E
Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA.
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins / Q000235:genetics / Q000302:isolation & purification*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D013687:Telencephalon / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D051153:Wnt Proteins; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D029961:Zebrafish Proteins; D000099274:Frizzled-Related Proteins
D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D000099274:Frizzled-Related Proteins; C094522:wnt8b protein, zebrafish