Modulatory activity of sildenafil on copulatory behaviour of both intact and castrated male rats.
The first experiment of the present study investigates the effects induced by sildenafil (1 or 10 mg/kg po) on the copulatory behaviour of intact male rats, categorized, on the basis of seven consecutive mating pretests, as sluggish or normal ejaculators (SE or NE, respectively). The data obtained show that sildenafil modifies both sexual arousal and the ejaculatory mechanisms of copulation, diminishing ejaculation latency in both categories and increasing copulatory efficacy in SE rats; in addition, it reduced the inter-intromission interval in both SE and NE animals and the post-ejaculatory interval only in SE animals. The second experiment, conducted on rats 3 weeks after their castration, shows that sildenafil alone (1 or 10 mg/kg) did not modify copulatory failure. However, 3 months after castration, and 24 h after the last injection of testosterone (25 microg/kg sc) given twice weekly for 4 weeks, sildenafil (1 or 10 mg/kg) ameliorated rat copulatory performance.
Ottani
A
A
Department of Biomedical Sciences, Division of Pharmacology, University of Modena and Reggio Emilia, Via G. Campi 287, Italy.
Giuliani
D
D
Ferrari
F
F
D000818:Animals; D003307:Copulation / Q000187:drug effects* / Q000502:physiology; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology; D005260:Female; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D051381:Rats; D017208:Rats, Wistar; D000068677:Sildenafil Citrate; D013450:Sulfones
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate