Polymorphous low-grade adenocarcinoma of the salivary glands: clinicopathological and immunohistochemical study of a case.
Polymorphous low-grade adenocarcinoma (PLGA) is a distinctive salivary gland neoplasm with a predilection for intraoral sites. Histological and immunohistochemical analyses were used to study a case involving the minor salivary glands of the buccal mucosa in a 68-year-old woman. Histologically, the tumor was characterized by unenca-psulated, progressing and focally-infiltrative borders and showed variable growth patterns including solid, tubular, microcystic and cribriform; papillary and papillary-cystic areas of more than focal extent were present. Cytologically the neoplasm was composed of uniform, round to cuboidal cells with bland, round to oval nuclei. Immunohistochemical analysis showed that the tumor cells were positive for cytokeratin, S-100 protein, vimentin, focally-positive for EMA and actin and negative for CEA. The significance of the papillary component and the possible relationship to other salivary gland tumors is discussed.
Tralongo
V
V
Servizio di Anatomia ed Istologia Patologica e Citopatologia, Presidio Ospedaliero G.F. Ingrassia-Azienda, Palermo, Italy. vtralongo@hotmail.com
Becchina
G
G
Genovese
F
F
Nagar
C
C
Ottoveggio
G
G
Pinto
G
G
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009061:Mouth Mucosa / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology