title: Suprasellar melanocytoma: a case of primary radiotherapy and review of the literature.
abstract: Meningeal melanocytoma is a rare benign neoplasm of the central nervous system. Approximately 50% of the tumors are located intracranially with a preference for posterior fossa. We report a new case of intracranial suprasellar melanocytoma in a 57-year-old male patient treated with primary high-dose conformal radiotherapy to 50.4 Gy. Fourty-two months subsequent to treatment the tumor is well under control without neither deterioration of clinical symptoms nor progression of gross tumor volume on MR imaging. No late sequelae of treatment have been observed. A review of the literature is presented indicating that resection of melanocytoma is the treatment of first choice hampered by a relapse rate of approximately 30% depending on resection status. The role of adjuvant radiotherapy in patiens with complete resection of melanocytoma has not yet been defined. These patients carry a risk of relapse of approximately 15%, and adjuvant irradiation is currently not recommended. Primary high-dose radiotherapy has been shown to be effective in long-term control of the neoplasm in patients where no resection of the tumor could be accomplished. In case of incomplete resection of melanocytoma, data of the literature indicate that adjuvant radiotherapy may in fact increase long-term local control of the tumor. Requirements for optimal treatment results of radiotherapy are sufficiently high doses of, at least, 50 Gy for intracranial lesions and three-dimensional treatment planning guaranting precise targeting of the tumor volume with only a low-risk of late sequalae to the surrounding tissues.
authors.affiliation: Department of Radiation Oncology, Tübingen University, Germany. johannes.classen@med.uni-tuebingen.de
authors.forename: Johannes
authors.initials: J
authors.lastname: Classen
authors.forename: Thomas
authors.initials: T
authors.lastname: Hehr
authors.forename: Werner
authors.initials: W
authors.lastname: Paulus
authors.forename: Karl
authors.initials: K
authors.lastname: Plate
authors.forename: Michael
authors.initials: M
authors.lastname: Bamberg
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy*; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy*; D008875:Middle Aged; D012658:Sella Turcica