title: Determining depth of invasion by VN pit pattern analysis in submucosal colorectal carcinoma.
abstract: The aim of this study was to clarify whether the pit pattern on the surface of submucosal colorectal carcinoma is associated with level of invasion. We examined the VN pit-pattern (loss or decrease of pits with an amorphous structure) area of the tumor surface in 18 submucosal carcinomas that were classified based on gross appearance as either superficial or broad based sessile polypoid tumors. Pit pattern determination was made according to a previously reported system. We then evaluated the relation between the VN pit-pattern area, the maximum diameter of the VN pit-pattern area obtained stereoscopically after resection, and the depth of submucosal invasion. There was a significant correlation between the area and maximum diameter of the VN pit-pattern segment. There was also significant correlation between the maximum diameter of the VN pit-pattern area and the depth of submucosal invasion. Lesions with a maximum VN pit-pattern area diameter <5 mm showed a depth of submucosal invasion of <1500 microm. In submucosal colorectal carcinoma of the superficial or broad based sessile polypoid type in gross appearance, measurement of the maximum VN pit-pattern area diameter allows estimation of the depth of submucosal invasion.
authors.affiliation: Department of Endoscopy, Hiroshima University Medical Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. colon@hiroshima-u.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagata
authors.forename: Shiro
authors.initials: S
authors.lastname: Oka
authors.forename: Toshio
authors.initials: T
authors.lastname: Kuwai
authors.forename: Tadamasa
authors.initials: T
authors.lastname: Tamura
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kitadai
authors.forename: Masaharu
authors.initials: M
authors.lastname: Sumii
authors.forename: Masaharu
authors.initials: M
authors.lastname: Yoshihara
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
mesh_terms: D002277:Carcinoma / Q000145:classification / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000145:classification / Q000473:pathology*; D004724:Endoscopy; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000379:methods*