title: Metabolic effects of infection and postnatal steroids.
abstract: Optimal development of the newborn depends on rapid accretion of substrate in the neonatal period, particularly in the premature infant. Steroids and infection not only induce catabolism, but associated endogenous responses reprioritize crucial substrate to restore homeostasis. The result is a protein/energy deficit and concomitant delay in growth and development. Innovative feeding strategies and novel therapies are needed to reduce the impact of catabolism in this population.
authors.affiliation: Department of Pediatrics, University of Minnesota, MMC 185, Minneapolis, MN 55455, USA. schwa005@tc.umn.edu
authors.forename: Sarah Jane
authors.initials: SJ
authors.lastname: Schwarzenberg
authors.forename: Andras
authors.initials: A
authors.lastname: Kovacs
mesh_terms: D002657:Child Development / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D007239:Infections / Q000378:metabolism*; D050356:Lipid Metabolism; D018977:Micronutrients / Q000378:metabolism; D009751:Nutritional Requirements; D011506:Proteins / Q000378:metabolism*; D018805:Sepsis / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D018977:Micronutrients; D011506:Proteins