Stochastic sensing of IP(3) has far-reaching consequences.
Hagan Bayley's group at Texas A&M University has devised a stochastic sensing methodology for the quantitation of the second messenger inositol 1,4,5-trisphosphate. The unique sensing scheme is very selective and has the potential to measure cytosolic concentrations of IP(3).
Anslyn
Eric V
EV
Department of Chemistry and Biochemistry, The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78737, USA.
Shear
Jason B
JB
D001692:Biological Transport; D015374:Biosensing Techniques; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D019791:Guanidine / Q000737:chemistry; D006460:Hemolysin Proteins / Q000737:chemistry; D015544:Inositol 1,4,5-Trisphosphate / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D007477:Ions; D012680:Sensitivity and Specificity; D015398:Signal Transduction
D006460:Hemolysin Proteins; D007477:Ions; D015544:Inositol 1,4,5-Trisphosphate; D019791:Guanidine