title: IL-17 as a potential target for modulating airway neutrophilia.
abstract: Several chronic inflammatory airway diseases are characterized by an increased number of neutrophils in the airways. There is evidence that the recruitment of these neutrophils can be controlled by certain T-lymphocytes. However, the mechanisms behind this T-cell control of airway neutrophilia are poorly understood. In this review, we summarize the evidence that interleukin (IL)-17 released from T-lymphocytes of the CD45RO+ subset can link the activation of these T-cells to the recruitment and activation of neutrophils. This evidence suggests that pharmacotherapeutical modulation of neutrophilic airway inflammation can be achieved using several different strategies, including inhibition of IL-17 production by cAMP elevating agents or certain nuclear factor inhibitors, neutralization of released IL-17 protein by specific anti-IL-17-antibodies, blockade of the IL-17 receptor as well as inhibition of certain MAP kinases mediating the post receptor effects of IL-17 in airway cells. Additional studies on animals in vivo and patients, respectively, are needed to further evaluate the pharmacotherapeutical potential of these strategies.
authors.affiliation: Lung Pharmacology Group, Department of Respiratory Medicine Allergology, Guldhedsgatan 10A, Gothenburg, SE-413 46, Sweden. martti.laan@hjl.gu.se
authors.forename: Martti
authors.initials: M
authors.lastname: Laan
authors.lastname: Lindén
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000276:immunology; D008775:Methylprednisolone / Q000494:pharmacology; D020556:Neutrophil Infiltration / Q000187:drug effects / Q000276:immunology*; D018123:Receptors, Interleukin / Q000037:antagonists & inhibitors; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D012140:Respiratory Tract Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D016207:Cytokines; C109985:IL17RA protein, human; D020381:Interleukin-17; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins; D016572:Cyclosporine; D008775:Methylprednisolone