Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man.
Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits.
Boube
Muriel
M
Centre de Biologie du Développement, Université Paul Sabatier, 31062, Toulouse Cedex, France.
Joulia
Laurent
L
Cribbs
David L
DL
Bourbon
Henri-Marc
HM
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D005057:Eukaryotic Cells; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D012319:RNA Polymerase II / Q000737:chemistry / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics
D005656:Fungal Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II