[The prevalence of serum IgG antibodies against HTLV viruses type I and II in sarcoidosis patients].
The pathogenesis of sarcoidosis remains still unknown. Among numerous factors viruses are considered as potential causes. The aim of the study was investigation of human T-cell lymphotopic virus type I (HTLV-I) in sarcoidosis patients. Studied group (I) consisted of 52 patients: 29 women and 23 men aged from 24 to 62 years; mean age 40 years. The diagnosis of sarcoidosis was confirmed by histologic examination in 46 patients and on the base of clinical, HRCT--chest scan and BAL findings in 6 patients. Control group (II) consisted of 92 various pulmonary disorders patients and healthy subjects in the aged from 20 to 83 years; mean age 54 years. In both groups the ELISA test detecting antibodies against HTLV-I/II was performed with the use the diagnostic kit produced by Organon Teknika, Belgium. Results were interpreted by measuring the optical density (OD). The cut-off point 0.386 was established according to the rule defined by kit's producent. The values of OD ranged in group I from 0.061 to 0.384 and in group II from 0.047 to 0.213; thus, no positive results of the test were observed. The values of OD did not differ significantly in both groups (p = 0.59).


CONCLUSIONS
In our region the participation of HTLV-I in the pathogenesis of sarcoidosis is doubtful.
Siemińska
Alicja
A
Katedry i Kliniki Chorób Płuc i Gruźlicy AM w Gdańsku.
Jassem
Ewa
E
Dziadziuszko
Rafał
R
Wolska-Goszka
Ludwika
L
Słomiński
Jan Marek
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood*; D015482:HTLV-II Antibodies / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000276:immunology / Q000821:virology*; D018709:Statistics, Nonparametric
D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies; D007074:Immunoglobulin G