title: Bionic technology revitalizes native baroreflex function in rats with baroreflex failure.
abstract: BACKGROUND
  We developed a bionic technology for the treatment of baroreflex failure and tested its efficacy in restoration of arterial pressure against head-up tilt (HUT) in rats with baroreflex failure.
  
  
  RESULTS
  The bionic baroreflex system (BBS) was a negative feedback system controlled by a computer, the artificial vasomotor center. It sensed systemic arterial pressure (SAP) through a micromanometer placed in the aortic arch and automatically computed the frequency of a pulse train to stimulate sympathetic efferent nerves. We selected the celiac ganglion as the sympathetic vasomotor interface. To make this system bionic, the operational rule of the artificial vasomotor center (H(BRP-->STM); BRP indicates baroreceptor pressure; STM, electrical stimulation) was actively matched to that of the native center. First, we identified the open-loop transfer functions of the native baroreflex control of SAP (H(Native)) and the response of SAP to electrical stimulation of the celiac ganglion (H(STM-->SAP)). We computed H(BRP-->STM) from H(Native)/H(STM-->SAP) and transplanted the operational rule into the computer. In 10 rats with baroreflex failure, we evaluated the performance of the BBS during rapid hypotension induced by HUT. Abrupt HUT dropped SAP by 34+/-6 mm Hg in 2 seconds and by 52+/-5 mm Hg in 10 seconds. During real-time execution of the BBS, on the other hand, the fall in SAP was 21+/-5 mm Hg at 2 seconds and 15+/-6 mm Hg at 10 seconds after HUT. These arterial responses controlled by the BBS were indistinguishable from those by the native baroreflex.
  
  
  CONCLUSIONS
  We concluded that the BBS revitalized the native baroreflex function in rats with baroreflex failure.
authors.affiliation: Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Japan. tacsato-kochimed@umin.ac.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sato
authors.forename: Toru
authors.initials: T
authors.lastname: Kawada
authors.forename: Masaru
authors.initials: M
authors.lastname: Sugimachi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001701:Bionics / Q000379:methods*; D001794:Blood Pressure; D004558:Electric Stimulation; D005728:Ganglia, Sympathetic / Q000503:physiopathology; D007024:Hypotension, Orthostatic / Q000503:physiopathology* / Q000628:therapy; D007700:Kinetics; D008297:Male; D008955:Models, Cardiovascular; D011187:Posture; D051381:Rats; D017207:Rats, Sprague-Dawley; D014666:Vasomotor System / Q000503:physiopathology