title: Treatment of metastatic rhabdoid tumor of the kidney.
abstract: Metastatic rhabdoid tumor of the kidney (RTK) is a highly lethal malignancy; only one survivor with stage 4 disease has been reported. The authors reviewed the cases of two patients with metastatic RTK who had excellent responses to therapy. Both patients were treated with radiation therapy and alternating courses of ifosfamide, carboplatin, and etoposide (ICE) and vincristine, doxorubicin, and cyclophosphamide (VDC). The patients are without evidence of disease at 24 months and 12 months from the detection of metastasis. Alternating courses of ICE and VDC have activity against metastatic RTK. This combination of agents warrants prospective investigation in clinical trials.
authors.affiliation: Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
authors.forename: Lars
authors.initials: L
authors.lastname: Wagner
authors.forename: D Ashley
authors.initials: DA
authors.lastname: Hill
authors.forename: Christine
authors.initials: C
authors.lastname: Fuller
authors.forename: Márcia
authors.initials: M
authors.lastname: Pedrosa
authors.forename: Manoo
authors.initials: M
authors.lastname: Bhakta
authors.forename: Arie
authors.initials: A
authors.lastname: Perry
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dome
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D009367:Neoplasm Staging; D018335:Rhabdoid Tumor / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D016190:Carboplatin; D007069:Ifosfamide