Loss of capacity to elevate plasma cortisol in rainbow trout (Oncorhynchus mykiss) treated with a single injection of o,p'-dichlorodiphenyldichloroethane.
The organochlorine o,p'- dichlorodiphenyldichloroethane (o,p'-DDD) is a metabolite of dichlorodiphenyltrichloroethane (DDT), known for its adrenolytic actions in birds and mammals. The effects of o,p'-DDD on the cortisol stress response were investigated in rainbow trout, Oncorhynchus mykiss, in a dose-response study in vivo. A dose-dependent decrease in plasma cortisol levels was observed on days 7 and 14 after a single i.p. injection of o,p'-DDD. Treatment with o,p'-DDD had no effect on weight gain, hematocrit, and gonado- or hepatosomatic index but decreased liver glycogen reserves. The results indicate that o,p'-DDD is an adrenotoxic compound in rainbow trout and that its effects can be detected even 14 d postinjection.
Benguira
Sandrine
S
Département des Sciences Biologiques, Université du Québec à Montréal, TOXEN Research Centre, Canada.
Leblond
Vincent S
VS
Weber
Jean-Philippe
JP
Hontela
Alice
A
D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D001835:Body Weight; D006003:Glycogen / Q000378:metabolism; D006400:Hematocrit; D006854:Hydrocortisone / Q000097:blood*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000737:chemistry; D008939:Mitotane / Q000494:pharmacology*; D017686:Oncorhynchus mykiss / Q000502:physiology*
D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane; D006003:Glycogen; D006854:Hydrocortisone