Study of the pathogenesis of Ebola fever in laboratory animals with different sensitivity to this virus.
Pathophysiological parameters were compared in animals with different sensitivity to Ebola virus infected with this virus. Analysis of the results showed the differences in immune reactions underlying the difference between Ebola-sensitive and Ebola-resistant animals. No neutrophil activation in response to Ebola virus injection was noted in Ebola-sensitive animal. Phagocytic activity of neutrophils in these animals inversely correlated with animal sensitivity to Ebola virus. Animal susceptibility to Ebola virus directly correlated with the decrease in the number of circulating T and B cells. We conclude that the immune system plays the key role in animal susceptibility and resistance to Ebola virus.
Chepurnov
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AA
Laboratory of Especially Dangerous Viral Infection, Vektor State Research Center for Virology and Biotechnology, Ministry of Health, Kol'tsovo, Novosibirsk Region. chepurnov@vector.nsc.ru
Dadaeva
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AA
Kolesnikov
S I
SI
D000818:Animals; D001402:B-Lymphocytes / Q000821:virology*; D029043:Ebolavirus / Q000472:pathogenicity*; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000473:pathology*; D009504:Neutrophils / Q000821:virology; D010587:Phagocytosis; D011817:Rabbits; D013601:T-Lymphocytes / Q000821:virology*