title: Expression of DNA topoisomerase IIalpha in oligodendroglioma.
abstract: BACKGROUND
  DNA Topoisomerase ha (Topo flu) is a nuclear enzyme whose expression levels are related to tumor cell growth and to resistance to anticancer chemotherapy.
  
  
  METHODS
  Topo ha expression was assessed immunohistochemically in 60 surgical specimens of 47 consecutive oligodendroglioma patients. Expression levels were correlated with the MIB-1 proliferation index and with patient outcome.
  
  
  RESULTS
  Topo flu expression ranges from 0.3 to 40.1% and is significantly associated with MIB-) staining. There is a weak trend to a higher expression of Topo flu in anaplastic oligodendrogliomas (p = 0.08). Topo ha expression is not related to patient outcome.
  
  
  CONCLUSIONS
  Topo flu expression appears to serve as a marker for tumor growth in human oligodendrogliomas. The widely vaiying expression levels of Topo ha in oligodendroglioma suggest this enzyme could be used for targeted selection of patients for Topo flu-interfering chemotherapy.
authors.affiliation: Institute of Neurology, Department of Neurosurgery, University of Vienna, Wien, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Bredel
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gatterbauer
authors.forename: Peter
authors.initials: P
authors.lastname: Birner
authors.forename: Christine
authors.initials: C
authors.lastname: Haberler
authors.forename: Thomas
authors.initials: T
authors.lastname: Ströbel
authors.forename: Herbert
authors.initials: H
authors.lastname: Budka
authors.forename: Karl
authors.initials: K
authors.lastname: Rössler
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Hainfellner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D001932:Brain Neoplasms / Q000201:enzymology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004250:DNA Topoisomerases, Type II / Q000096:biosynthesis*; D004268:DNA-Binding Proteins; D006801:Humans; D008875:Middle Aged; D009837:Oligodendroglioma / Q000201:enzymology* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D000951:Antigens, Neoplasm; D004268:DNA-Binding Proteins; D004250:DNA Topoisomerases, Type II