title: Intracranial perineural extension of invasive mycosis: a novel mechanism of disease propagation by Aspergillus fumigatus.
abstract: We describe an immunocompetent woman who had refractory, invasive sphenoid sinus Aspergillus fumigatus infection for which there was radiologic evidence of intracranial perineural spread. The patient responded to a combination of antifungal and adjuvant recombinant cytokine therapy.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of South Carolina School of Medicine, PalmettoRichland Memorial Hospital, Columbia, SC 29203, USA. safdar@richmed.medpark.sc.edu
authors.forename: Amar
authors.initials: A
authors.lastname: Safdar
authors.forename: Martin P
authors.initials: MP
authors.lastname: Dommers
authors.forename: Rohit
authors.initials: R
authors.lastname: Talwani
authors.forename: Charlotte R
authors.initials: CR
authors.lastname: Thompson
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D001232:Aspergillus fumigatus; D016207:Cytokines / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007121:Immunocompetence; D010502:Perineum / Q000382:microbiology*; D011859:Radiography
chemical_list: D000935:Antifungal Agents; D016207:Cytokines