Insulin-like growth factor-II induces hypertrophy of adult cardiomyocytes via two alternative pathways.
Insulin-like growth factor (IGF)-II is known to induce hypertrophy of isolated adult rat ventricular cardiomyocytes cultured in the absence of serum. However, it is not known how the growth factor exerts this hypertrophic effect. We show here that IGF-II induces hypertrophy of the cultured cardiomyocytes via two alternative pathways: (1) an IGF-I receptor-dependent pathway, or (2) a lysosome-dependent pathway when the IGF-I receptor-dependent pathway is blocked.
Huang
Chih-Yang
CY
Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA.
Hao
Ling-Yang
LY
Buetow
Dennis E
DE
D000818:Animals; D000906:Antibodies; D006332:Cardiomegaly / Q000378:metabolism*; D002478:Cells, Cultured; D007335:Insulin-Like Growth Factor II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017526:Receptor, IGF Type 1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D000906:Antibodies; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1