Embarrassed, but not depressed: eye opening lessons for cerebellar learning.
Cellular mechanisms of plasticity must be linked to circuit mechanisms of behavior to understand learning and memory. Studies of how learning occurs in cerebellar circuits for classical conditioning of eyeblinks are meeting this challenge admirably. Several recent papers have added to the richness of our understanding of cerebellar learning by correlating complex aspects of learned behaviors with hitherto underappreciated properties of the cerebellar circuit.
Carey
Megan
M
W.M. Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program and Department of Physiology, University of California, San Francisco, CA 94143, USA. mcarey@phy.ucsf.edu
Lisberger
Stephen
S
D000818:Animals; D002531:Cerebellum / Q000166:cytology / Q000502:physiology*; D003215:Conditioning, Eyelid / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008959:Models, Neurological; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*