Signal transduction and endocytosis: close encounters of many kinds.
Binding of hormones, growth factors and other cell modulators to cell-surface receptors triggers a complex array of signal-transduction events. The activation of many receptors also accelerates their endocytosis. Endocytic transport is important in regulating signal transduction and in mediating the formation of specialized signalling complexes. Conversely, signal-transduction events modulate specific components of the endocytic machinery. Recent studies of protein tyrosine kinases and G-protein-coupled receptors have shed new light on the mechanisms and functional consequences of this bidirectional interplay between signalling and membrane-transport networks.
Sorkin
Alexander
A
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80111, USA. alexander.sorkin@uchsc.edu
Von Zastrow
Mark
M
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism; D008024:Ligands; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D046911:Macromolecular Substances; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch