title: Point mutation in the alpha helix of the HLA-C alpha2 domain generates a novel HLA-C allele,HLA-Cw*0106, in a Han Chinese individual in Taiwan.
abstract: We report herein the identification of a new HLA-C allele using sequence-based typing (SBT). This novel allele, HLA-Cw*0106, was found in a Han Chinese individual from Taiwan. This individual was typed using SBT as having a class I HLA genotype of HLA-A*0206/0207, HLA-B*4601/5601, and HLA-Cw*0102/0106. This new allele differs from HLA-Cw*0102 in one of the nucleotides of the polymorphic exon 3 at codon 152 (GAG-->GTG; E152V). This residue is located in the alpha helix of the HLA-C alpha2 domain and may have the potential to affect the binding of HLA-C molecules with antigenic peptides and/or the interactions with the T cell receptor. This new allele was detected in a few individuals of Han Chinese in Taiwan, but has not yet been observed in the aboriginal populations in Taiwan.
authors.affiliation: Tzu Chi University, Taiwan, ROC. shaokee@mail.tcu.edu.tw
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.forename: C-Y
authors.initials: CY
authors.lastname: Lai
authors.forename: S-M
authors.initials: SM
authors.lastname: Lai
authors.forename: S-P
authors.initials: SP
authors.lastname: Chen
authors.forename: F-C
authors.initials: FC
authors.lastname: Chou
authors.forename: Y-M
authors.initials: YM
authors.lastname: Shiao
authors.forename: C-S
authors.initials: CS
authors.lastname: Huang
mesh_terms: D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D015236:HLA-C Antigens / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D017433:Protein Structure, Secondary; D013624:Taiwan
chemical_list: D015236:HLA-C Antigens; C471431:HLA-C*01:06 antigen