Older adults with acute myeloid leukemia.
Acute myeloid leukemia (AML) occurs most frequently in older adults, with a median age range from 65 to 70 years. Both the disease and its treatment are distinct from their counterparts in young patients. Herein we characterize the intrinsic biologic features of AML as it occurs in the older population, review currently available therapeutic approaches, and discuss therapeutic strategies in development.
Sekeres
Mikkael A
MA
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Stone
Richard
R
D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D000375:Aging; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use; D004361:Drug Tolerance; D006133:Growth Substances / Q000627:therapeutic use; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D012008:Recurrence; D012074:Remission Induction
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D006133:Growth Substances; D003561:Cytarabine