title: Novel statistical classification model of type 2 diabetes mellitus patients for tailor-made prevention using data mining algorithm.
abstract: To estimate the usefulness of data mining algorithms for extracting risk predictors of diabetic vascular complications in proper order in the future, we tried applying the Classification and Regression Trees (CART) method to the prevalence data of 165 type 2 diabetic outpatients and already known risk factors. Among the 6 categorical and 15 continuous risk factors, age (cutoff: 65.4) was the best predictor for classifying patients into groups with and without macroangiopathy (p=0.000). Body weight (cutoff: 53.9) was the best predictor (p=0.006) in the older group (age >65.4), whereas systolic blood pressure (cutoff: 144.5) was the best predictor in the remaining group (p=0.002). Age (cutoff: 64.8) was also the best predictor for categorizing them into groups with and without microangiopathy (p=0.000). In the older group (age >64.8), BMI (cutoff: 21.5) was the best predictor (p=0.001), whereas morbidity term (cutoff: 15.5) was the best predictor in the other group (p=0.01 0). Because the orders and values of all risk factors and cutoff points mined were reasonable clinically, this method may have the potential to highlight predictors in order of importance to apply tailor-made prevention of diabetic vascular complications.
authors.affiliation: Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Miyaki
authors.forename: Izumi
authors.initials: I
authors.lastname: Takei
authors.forename: Kenji
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Omae
mesh_terms: D000465:Algorithms; D003924:Diabetes Mellitus, Type 2 / Q000145:classification* / Q000150:complications / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors