title: Effect of Hypericum extract on the hypothalamic-pituitary-adrenal system in rats.
abstract: We studied the effect of Hypericum extract on activity of the hypothalamic-pituitary-adrenal system in rats. In rats exposed to stress after a 30-day daily oral treatment with Hypericum extract, the weight of the adrenals and ACTH concentration were lower than in controls. Hence, treatment with Hypericum extract improved resistance to stress and prevented exhausting of the hypothalamic-pituitary-adrenal system.
authors.affiliation: I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
authors.forename: D M
authors.initials: DM
authors.lastname: Makina
authors.forename: A G
authors.initials: AG
authors.lastname: Taranukhin
authors.forename: E V
authors.initials: EV
authors.lastname: Chernigovskaya
authors.forename: V V
authors.initials: VV
authors.lastname: Kuzik
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects* / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000818:Animals; D020902:Hypericum / Q000737:chemistry*; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D010936:Plant Extracts; D000324:Adrenocorticotropic Hormone