title: Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury.
abstract: We have studied and compared the antinociceptive and anti-hyperalgesic effect of the partial opioid receptor agonist buprenorphine in normal and neuropathic rats. In normal rats, systemic buprenorphine produced dose-dependent antinociception on the hot plate test. In rats with peripheral nerve or spinal cord injury, buprenorphine markedly alleviated neuropathic pain-related behaviors, including mechanical and cold allodynia/hyperalgesia at doses comparable to that producing antinociception. The results suggest that buprenorphine may be a useful analgesic for treating neuropathic pain and thus is an atypical opioid since morphine tends to be less potent after nerve injury.
authors.affiliation: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden.
authors.forename: Poli Francois
authors.initials: PF
authors.lastname: Kouya
authors.forename: Jing-Xia
authors.initials: JX
authors.lastname: Hao
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Xu
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000818:Animals; D002047:Buprenorphine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007278:Injections, Spinal; D007279:Injections, Subcutaneous; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries*; D013119:Spinal Cord Injuries / Q000150:complications*; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine