title: Reaction of alpha,alpha-dibromo oxime ethers with Grignard reagents: alkylative annulation providing a pyrimidine core.
abstract: A convergent synthesis of a pyrimidine core has been achieved. Treatment of alpha,alpha-dibromo oxime ethers, which are easily derived from the corresponding esters, with a variety of Grignard reagents provides trisubstituted pyrimidines in good yields. This new method offers an easy access to functionalized pyrimidines.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Hirotada
authors.initials: H
authors.lastname: Kakiya
authors.forename: Kazunari
authors.initials: K
authors.lastname: Yagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shinokubo
authors.forename: Koichiro
authors.initials: K
authors.lastname: Oshima