Value of mucin detection in distinguishing mucoepidermoid carcinoma from Warthin's tumor on fine needle aspiration.
OBJECTIVE
To examine the validity of the presence of mucin, utilizing a semiquantitative, statistical approach, as a criterion for distinguishing low to intermediate grade mucoepidermoid carcinoma (ME) from Warthin's tumor (WT).


METHODS
We selected histologically established fine needle aspiration (FNA) cases of ME (26) and WT (30) from a six-year period (January 1995-January 2001). Mucicarmine staining was performed on the FNA preparations. The amount of mucin detected was rated on a scale of 1-3, as follows: 1 = no mucin present, 2 = mucin present in the background and < 5% of tumor cells, and 3 = mucin present in the background and > or = 5% tumor cells. The scores for the 30 WTs and 26 MEs were tabulated and analyzed for statistical significance utilizing the Student t test.


RESULTS
The mean mucin score for the 26 MEs was 1.81, SD .63. The mean mucin score for the 30 WTs was 1.52, SD .74. There was no statistically significant difference (P = .122) in the amount of mucin present between MEs and WTs in the 56 aspirate specimens examined.


CONCLUSIONS
Based on the results of this study, the presence of extracellular or intracellular mucin in FNA specimens of salivary gland tumors may not be a reliable criterion for distinguishing WT from ME.
Goonewardene
Shanth A
SA
Cytopathology and Cytometry Section, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street/6 Founders Pavilion, Philadelphia, Pennsylvania 19104, USA.
Nasuti
Joseph F
JF
D000235:Adenolymphoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001707:Biopsy, Needle; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D009077:Mucins / Q000032:analysis*; D015203:Reproducibility of Results
D014408:Biomarkers, Tumor; D009077:Mucins