title: Clinical implications of statin event trials.
abstract: Event trials using statin therapy have shown a beneficial effect on rates of cardiovascular events. The three statins that have been used in long-term trials have shown generally similar effects on rates of myocardial infarction, stroke, revascularizations, and mortality. Safety data appear to be comparable for lovastatin, pravastatin, and simvastatin. Long-term trials of other statins are in progress or pending. The question of how much low-density lipoprotein cholesterol should be lowered may be answered by studies currently in progress.
authors.affiliation: Lipid Research Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8046, St. Louis, MO 63110, USA. agoldber@im.wustl.edu
authors.forename: Anne Carol
authors.initials: AC
authors.lastname: Goldberg
mesh_terms: D003327:Coronary Disease / Q000401:mortality / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D011322:Primary Prevention / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors