Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity.
Two new flavonolignans, mururins A and B ( 1 and 2), and a new lignan, mururin C ( 3), were isolated from the bark of Brosimum acutifolium Huber together with three known lignans. Their structures were elucidated by spectroscopic means and chemical modifications. They were tested for protein kinase A (PKA) and protein kinase C (PKC) inhibitory activity. Mururin A showed 3 % and 63 % inhibition to PKA and PKC, respectively, at 20 microM. Mururin B showed 58 % and 38 % inhibition, respectively. Mururin C did not have significant activity.
Takashima
Junko
J
Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Takashima.Junko@me.m-pharma.co.jp
Asano
Shoichi
S
Ohsaki
Ayumi
A
D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D002942:Circular Dichroism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029586:Moraceae / Q000737:chemistry*; D047428:Protein Kinase Inhibitors
D001572:Benzofurans; D001578:Benzopyrans; D004791:Enzyme Inhibitors; D017705:Lignans; D047428:Protein Kinase Inhibitors; C464947:mururin A; C464948:mururin B; C464949:mururin C