[Acquired ichthyosis disclosing Hodgkin's disease. Simultaneous recurrence].
BACKGROUND
Hodgkin's lymphoma is rarely evidenced by dermatological signs or symptoms.


METHODS
A 37 year-old man progressively developed widespread cutaneous roughness, with small parallel lines producing fish-like scales. A skin biopsy confirmed the diagnosis of acquired ichthyosis, as evidenced by the absence of the epidermal granular layer. The patient's condition was assessed to be satisfactory. However, two months later, his general condition had gradually deteriorated (night sweats, weight loss, axillary and scalp alopecia, and adenopathies). Hodgkin's lymphoma was diagnosed. After treatment with adriamycin, bleomycin, vincristine and dacarbazine, complete remission of the lymphoma was obtained, and concomitantly, the symptoms of acquired ichthyosis resolved; this was confirmed by serial skin biopsies that evidenced the progressive complete restoration of the granular layer. The level of plasmatic vitamin A and carotene, which had decreased before the treatment, returned to normal values. A subsequent relapse of Hodgkin's lymphoma was preceded by the recurrence of ichthyosis; this time vitamin A and carotene levels were not decreased.


CONCLUSIONS
As a paraneoplastic syndrome, acquired ichthyosis as a first sign of Hodgkin's lymphoma is discussed. In the presence of acquired ichthyosis, repeated monitoring of the patient is required since clinical symptoms of Hodgkin lymphoma are often delayed. Acquired ichthyosis is also an early marker of lymphoma recurrence.
Ghislain
P D
PD
Service de dermatologie, Cliniques universitaires Saint-Luc, Université catholique de Louvain, 10 avenue Hippocrate B-1200 Bruxelles. PierreDominique.Ghislain@advalvas.be
Roussel
S
S
Marot
L
L
Tennstedt
D
D
Michaux
L
L
Lachapelle
J M
JM
D000328:Adult; D006689:Hodgkin Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D012008:Recurrence