[Peptide-protein complexes of angiotensins in the mechanisms of thirst].
The comparative analysis of learned and natural drinking behavior under native angiotensin-I (A-I), angiotensin-II (A-II) and its protein-peptides complexes (PPC) administration in rats, was performed. Various effects of these substances on drinking behavior were observed. PPC of A-I became a dipsogenic agent as compared with the native one. Moreover, PPC of A-II facilitated selectively learned and not natural forms of drinking behavior. It's suggested that PPC of angiotensins play a specific role in endogenous mechanisms of thirst. An important function of this complexes due to their conformational properties and participation in realization of basic needs, is discussed.
Kotov
A V
AV
Anokhin Research Institute of Normal Physiology of the Russian Acad. Med. Sci., Moscow 103009, 11 Mokhovaya St., Russia.
Tolpygo
S M
SM
Pevtsova
E I
EI
Obukhova
M F
MF
D000803:Angiotensin I / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D000804:Angiotensin II / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D002417:Cattle; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D013894:Thirst / Q000502:physiology*
D000804:Angiotensin II; D012710:Serum Albumin, Bovine; D000803:Angiotensin I; D002216:Captopril