Trioxolanes: A new generation of compounds with wide-ranging activities.
Direct biological activity of a 1,2,4-trioxolane derivative was assessed in vitro using bacteria and fungi causing common infections. The product was found to be uniformly active against all organisms tested. In addition, it is active against certain tumour cells and protozoa and is also an immunomodulator. These observations are discussed in the light of the product's potential use in the clinical management of conditions in which its use is indicated.
Koech
Davy K.
DK
Kenya Medical Research Institute, P. O. Box 54840, Nairobi, Kenya.
Herman
James A.
JA
Kofi-Tsekpo
Mawuli W.
MW
Herman
Stephen D.
SD