title: Insulin resistance and glomerular hemodynamics in essential hypertension.
abstract: BACKGROUND
  Arterial hypertension is an important cause of end-stage renal failure. Insulin has been shown to modify glomerular hemodynamics in hypertensive subjects. The aim of this work, therefore, was to observe the relationships between renal hemodynamics and insulin resistance in arterial hypertension.
  
  
  METHODS
  Sixty-two non-diabetic hypertensive patients and 25 healthy normal subjects were studied. Renal plasma flow and the glomerular filtration fraction were determined by renoscintigraphy and the insulin sensitivity by an oral glucose test.
  
  
  RESULTS
  Renal plasma flow in hypertensive subjects was lower than expected and was related to pressure values, whereas the mean glomerular filtration rates were not different in the two groups. In most patients the filtration fraction was higher than expected. A lower glomerular filtration rate and lower filtration fraction were found in patients with higher insulin resistance.
  
  
  CONCLUSIONS
  The progressive decrease of glomerular function in subjects with hypertension is linked with insulin-resistance.
authors.affiliation: Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Università degli Studi di Palermo, via Lenin Mancuso 15, 90129 Palermo, Italy. androp@unipa.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Andronico
authors.forename: Rosella
authors.initials: R
authors.lastname: Ferraro-Mortellaro
authors.forename: Maria T
authors.initials: MT
authors.lastname: Mangano
authors.forename: Maria
authors.initials: M
authors.lastname: Romé
authors.forename: Francesco
authors.initials: F
authors.lastname: Raspanti
authors.forename: Antonio
authors.initials: A
authors.lastname: Pinto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Licata
authors.forename: Giovanna
authors.initials: G
authors.lastname: Seddio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mulé
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cerasola
mesh_terms: D000328:Adult; D001794:Blood Pressure; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007333:Insulin Resistance; D007678:Kidney Glomerulus / Q000098:blood supply / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation