Plasticity and reprogramming of differentiated cells in amphibian regeneration.
Adult urodele amphibians, such as the newt, can regenerate their limbs and various other structures. This is the result of the plasticity and reprogramming of residual differentiated cells, rather than the existence of a 'reserve-cell' mechanism. The recent demonstrations of plasticity in mouse myotubes should facilitate comparative studies of the pathways that underlie the regenerative response, as well as proposing new approaches to promote mammalian regeneration.
Brockes
Jeremy P
JP
Department of Biochemistry & Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. j.brockes@ucl.ac.uk
Kumar
Anoop
A
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D005121:Extremities / Q000502:physiology; D006321:Heart / Q000502:physiology; D007498:Iris / Q000502:physiology; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology; D010802:Phylogeny; D011687:Purines / Q000378:metabolism; D012038:Regeneration / Q000502:physiology*; D014562:Caudata / Q000196:embryology / Q000502:physiology*
D011687:Purines; C407365:myoseverin