title: [The changes of bispectral index induced by administration of midazolam during propofol anesthesia].
abstract: The effect of the additional administration of midazolam or flumazenil on bispectral index (BIS) during propofol anesthesia was investigated in 22 scheduled surgical patients. Midazolam 10 or 30 micrograms.kg-1, or flumazenil 6 or 12 micrograms.kg-1 was injected to the patients to evaluate their effect on BIS after achieving steady state of hypnosis more than 1 hr of propofol anesthesia with 5 mg.kg-1.hr-1. The only midazolam 30 micrograms.kg-1 significantly reduced BIS value from 47.8 +/- 8.6 to 36.8 +/- 6.5. The synergistic interaction between midazolam and propofol assessed by BIS might be less clear than that assessed by hypnotic dose of propofol using psychopharmacological investigation.
authors.affiliation: Medical Corps, 1st Air Wing, Japan Air Self Defense Force, Hamamatsu 432-8551.
authors.forename: Maiko
authors.initials: M
authors.lastname: Satomoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoki
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yamada
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Umeda
authors.forename: Yushi
authors.initials: Y
authors.lastname: Adachi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Higuchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Satoh
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000494:pharmacology*; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D006801:Humans; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D015742:Propofol; D013514:Surgical Procedures, Operative
chemical_list: D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D008874:Midazolam; D015742:Propofol