Synthesis and effects on intracellular calcium of some 1,3-bis-(heteroaryl substituted)benzene derivatives.
A series of 1,3-bis-(heteroaryl substituted)benzene derivatives was designed as promising molecules which might increase intracellular Ca2+ level in F2408 fibroblast-like cells by affecting the Ca2+ channels on plasma membrane. Mentioned compounds were obtained by the treatment of isophtalaldehyde with benzil or 1,2-phenylenediamine derivatives. In this way, 13 compounds were synthesised and their structure elucidations were performed by IR, 1H NMR and mass spectroscopic data and elemental analysis results. Some of the compounds showed Ca2+ being released from the intact cells.
Meriç
Asiye
A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu, Eskişehir, Turkey.
Incesu
Zerrin
Z
Işikdağ
Ilhan
I
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D001555:Benzene Derivatives; D015220:Calcium Channels; D006571:Heterocyclic Compounds; D002118:Calcium