title: [Pathogenesis of NSAID-induced gastric mucosal damage--search for primary events and role of COX inhibition].
authors.affiliation: Department of Pharmacology and Experimental Therapeutics.
authors.forename: Koji
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Akiko
authors.initials: A
authors.lastname: Tanaka
authors.forename: Tohru
authors.initials: T
authors.lastname: Miyazawa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects; D007527:Isoenzymes / Q000502:physiology; D008565:Membrane Proteins; D009504:Neutrophils / Q000502:physiology; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology; D051381:Rats; D013272:Stomach Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; C496513:Ptgs1 protein, rat; D007213:Indomethacin