Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia.
The influence of haptoglobin polymorphisms on severe malaria occurrence was assessed in 1183 individuals from The Gambia. No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribonucleic acid-based haptoglobin typing method are discussed.
Aucan
Christophe
C
Wellcome Trust Centre For Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. aucan@well.ox.ac.uk
Walley
Andrew J
AJ
Greenwood
Brian M
BM
Hill
Adrian V S
AV
D016022:Case-Control Studies; D005714:Gambia; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D016778:Malaria, Falciparum / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic
D006242:Haptoglobins