title: Angiolymphoid hyperplasia with eosinophilia: a classic clinical presentation with histologic features of angiosarcoma.
abstract: BACKGROUND
  Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease manifested by the proliferation of morphologically distinct endothelial cells.
  
  
  OBJECTIVE
  To illustrate by a case report the clinical and varied histopathologic findings of ALHE.
  
  
  METHODS
  A 29-year-old woman presented with a clinical picture of ALHE but had several histologic features of angiosarcoma.
  
  
  RESULTS
  Management of this patient included repeat biopsies of the lesions, excision of the involved areas, careful histologic examination of the entire specimen, and appropriate follow-up.
  
  
  CONCLUSIONS
  ALHE may present with various histologic features. Knowledge of the spectrum of benign and malignant vascular neoplasms helps manage these challenging cases.
authors.affiliation: Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. zeitouni@roswellpark.org
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Zeitouni
authors.forename: Sameh
authors.initials: S
authors.lastname: Hanna
authors.forename: Thom R
authors.initials: TR
authors.lastname: Loree
authors.forename: John
authors.initials: J
authors.lastname: Brooks
authors.forename: Richard T
authors.initials: RT
authors.lastname: Cheney
mesh_terms: D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology; D006801:Humans; D012536:Scalp Dermatoses / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology