title: [Hyperstosis in patients with intracranial meningioma--secondary changes in tumor invasion].
abstract: A comprehensive clinical, histological, and immunohistochemical evaluation was done of 42 intracranial meningiomas in patients with hyperostosis in the postoperative period. It has been ascertained that hyperostosis in meningiomas is a direct bone tumour invasion. Bone invasion is not a sign of malignant transformation of meningiomas. It is shown that meningiomas with hyperostosis are hormone-dependent tumours. In tumours, there has been detected a high concentration of progesterone and estrogen active receptors. It is shown that hyperostosis is a consequence of hormone-related abnormalities of Ca metabolism. Special stress is laid on ridding the bone of hyperostosis at tumour removal to reduce the number of tumour recurrences.
authors.forename: M S
authors.initials: MS
authors.lastname: Kvasha
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015576:Hyperostosis / Q000150:complications*; D007150:Immunohistochemistry; D008579:Meningioma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone