title: Primipaternity and duration of exposure to sperm antigens as risk factors for pre-eclampsia.
abstract: OBJECTIVE
  To establish whether primipaternity and duration of unprotected sexual cohabitation is associated with an increased risk of pre-eclampsia.
  
  
  METHODS
  At a tertiary referral center, the study had a case and control group of 60 multigravid women each, as well as a case and control group of 50 primigravid women each. Information was compiled by means of a confidential questionnaire.
  
  
  RESULTS
  After multiple logistic regression analysis using age, smoking, hypertension in previous pregnancies, change of paternity and duration of unprotected sexual cohabitation as predictors, the regression coefficients for change of paternity and sexual cohabitation of longer than 6 months in multigravid women were -0.4 (P = 0.15) and -1.4 (P = 0.03), respectively.
  
  
  CONCLUSIONS
  Multigravid women with a period of unprotected sexual cohabitation of longer than 6 months had a decreased risk of pre-eclampsia. Primipaternity was not a significant risk factor for pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Tygerberg Hospital and Stellenbosch University, Tygerberg, South Africa.
authors.forename: G R
authors.initials: GR
authors.lastname: Verwoerd
authors.forename: D R
authors.initials: DR
authors.lastname: Hall
authors.forename: D
authors.initials: D
authors.lastname: Grové
authors.forename: J S
authors.initials: JS
authors.lastname: Maritz
authors.forename: H J
authors.initials: HJ
authors.lastname: Odendaal
mesh_terms: D000328:Adult; D000954:Antigens, Surface / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D020073:Gravidity / Q000276:immunology; D006801:Humans; D008297:Male; D010334:Paternity; D011225:Pre-Eclampsia / Q000209:etiology* / Q000276:immunology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012044:Regression Analysis; D012307:Risk Factors; D021841:Safe Sex; D012747:Sexual Partners; D013094:Spermatozoa / Q000276:immunology*; D013997:Time Factors
chemical_list: D000954:Antigens, Surface