title: Radiation treatment of T1-T4 squamous cell carcinoma of the larynx: a retrospective analysis and long-term follow-up of 135 patients.
abstract: OBJECTIVE
  To evaluate the long-term outcome of radiation therapy for patients with histologically verified squamous cell glottic carcinoma.
  
  
  METHODS
  A retrospective study was performed on patients who had received radiation treatment at the Department of Oncology, Uppsala University, Uppsala, Sweden, between 1978 and 1987 Patients with a documented follow-up for at least five years, or to time of death, were studied. Radiation treatment was delivered utilising daily fractions of 1.8-20 over 6-7 weeks, totalling 60-70 Gy. Patients whose tumours were not controlled by radiation therapy, or whose tumours recurred, were offered surgical intervention.
  
  
  RESULTS
  The study included 135 patients. Five-year survival rates adjusted to death due to laryngeal carcinoma were: T1, 95%; T2, 87%; T3, 72% and T4, 25%.
  
  
  CONCLUSIONS
  Primary radiotherapy achieves a high rate of cure for T1-T2 laryngeal carcinoma. Tumour-related morbidity and death continued beyond the standard five-year follow-up, especially for patients with T1/T2 laryngeal carcinomas.
authors.affiliation: Department of Oncology, University Hospital, Uppsala, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Bergqvist
authors.forename: Ola
authors.initials: O
authors.lastname: Brodin
authors.forename: Anki
authors.initials: A
authors.lastname: Pouzon
authors.forename: Arne
authors.initials: A
authors.lastname: Linder
authors.forename: Patrik
authors.initials: P
authors.lastname: Hesselius
authors.forename: Erik
authors.initials: E
authors.lastname: Blomquist
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome