Induced humoral immunity and vaccination against major human fungal pathogens.
Protection against fungal pathogens can theoretically be elicited by vaccines that stimulate humoral or cellular immunity, or both. There is conclusive evidence that humoral immunity can modify the course of infection against certain pathogenic fungi such as Candida albicans and Cryptococcus neoformans. However, for other fungi, such as Aspergillus fumigatus, the notion that humoral immunity contributes to host defence is unproven. Attempts to evaluate the potential efficacy of humoral immunity using immune sera are often inconclusive, whereas consistent results can be obtained with monoclonal antibodies. Protective monoclonal antibodies can be used to identify antigens that induce useful humoral responses.
Casadevall
Arturo
A
Department of Medicine, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA. casadeva@aecom.yu.edu
Feldmesser
Marta
M
Pirofski
Liise-anne
LA
D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood*; D001232:Aspergillus fumigatus / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D003455:Cryptococcus neoformans / Q000276:immunology; D005657:Fungal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D051379:Mice; D003904:Mitosporic Fungi / Q000276:immunology*; D009181:Mycoses / Q000382:microbiology / Q000517:prevention & control*; D014611:Vaccination
D000908:Antibodies, Fungal; D005657:Fungal Vaccines