title: RNA interference: the new somatic cell genetics?
abstract: RNAi is evolving into a powerful tool for manipulating gene expression in mammalian cells with potential utility for investigating gene function, for high-throughput, function-based genetic screens and potentially for development as a therapeutic tool.
authors.affiliation: Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Paddison
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Hannon
mesh_terms: D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D020732:Cytogenetic Analysis; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D015870:Gene Expression; D020868:Gene Silencing; D006801:Humans; D008957:Models, Genetic; D012330:RNA, Double-Stranded / Q000737:chemistry / Q000235:genetics; D034741:RNA, Small Interfering / Q000138:chemical synthesis / Q000235:genetics* / Q000378:metabolism; D014764:Viral Proteins
chemical_list: D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering; D014764:Viral Proteins; C062210:bacteriophage T7 RNA polymerase; D012321:DNA-Directed RNA Polymerases