title: Evaluation of vision-related quality of life of patients wearing photochromic lenses.
abstract: OBJECTIVE
  A two-period, crossover study was undertaken comparing next-generation gray photochromic Transitions Lenses (Transitions Optical, Inc., Pinellas Park, FL) with clear lenses and a study purple-colored photochromic lens to evaluate enhancement to vision-related quality of life (VRQOL).
  
  
  METHODS
  Fifty-two patients were randomized into one of four lens crossover groups: gray-->clear; clear-->gray; gray-->purple; and purple-->gray. Each lens was worn for 30 days. VRQOL was measured using a previously administered questionnaire, the Transitions Vision Related Quality of Life' (TVRQOL) survey instrument (see Appendix to this article). Differences in responses related to each lens worn in the comparison were recorded.
  
  
  RESULTS
  Overall, next-generation gray Transitions Lenses were associated with the greatest improvement in VRQOL compared to clear or purple lenses. The gray lens proved statistically superior to the clear lens, across four of the five subscales. When given the choice of which lens they would like to continue to wear, 85% (23 of 27) of the patients preferred the gray lens. No statistically significant difference was observed between the gray lens and the study purple lens.
  
  
  CONCLUSIONS
  Next-generation gray Transitions Lenses offer patients significant and clinically meaningful improvements in VRQOL, and are superior to clear lenses. A patient's overall visual experience is best served by proper product selection to provide optimal visual acuity and VRQOL performance.
authors.affiliation: Department of Ophthalmology, New York University School of Medicine, NY, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Stenson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Scherick
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Baldy
authors.forename: Karen A F
authors.initials: KA
authors.lastname: Copeland
authors.forename: Joel
authors.initials: J
authors.lastname: Solomon
authors.forename: Carol
authors.initials: C
authors.lastname: Bratteig
mesh_terms: D000293:Adolescent; D000328:Adult; D018592:Cross-Over Studies; D005139:Eyeglasses; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D055095:Optics and Photonics; D017060:Patient Satisfaction; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014792:Visual Acuity