Insect oostatic peptide: absence of effect on mice ovaries.
An analogue of insect oostatic peptide, the pentapeptide H-Tyr-Asp-Pro-Ala-Pro-OH (H-YDPAP-OH), was administered to female mice and its effects on reproduction and development of the ovaries were studied. Up to 0.5 mg of the peptide per mice (25 g b.w.) injected intraperitoneally did not change the rate of pregnancy, number of offsprings and histological findings in ovaries and uterus in comparison to saline treated controls.
Slaninová
Jirina
J
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague. slan@marilyn.uochb.cas.cz
Bennettová
Blanka
B
Hlavácek
Jan
J
Tykva
Richard
R
D000818:Animals; D005260:Female; D005298:Fertility; D007274:Injections, Intraperitoneal; D007301:Insect Hormones / Q000494:pharmacology*; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal
D007301:Insect Hormones; D009842:Oligopeptides; C065612:Peptide oostatic hormone