ZntB is a novel Zn2+ transporter in Salmonella enterica serovar Typhimurium.
A Zn2+ transport system encoded by the zntB locus of Salmonella enterica serovar Typhimurium has been identified. The protein encoded by this locus is homologous to the CorA family of Mg2+ transport proteins and is widely distributed among the eubacteria. Mutations at zntB confer an increased sensitivity to the cytotoxic effects of Zn2+ and Cd2+, a phenotype that suggests that the encoded protein mediates the efflux of both cations. A direct analysis of transport activity identified a capacity for Zn2+ efflux. These data identify ZntB as a zinc efflux pathway in the enteric bacteria and assign a new function to the CorA family of cation transporters.
Worlock
Ashley J
AJ
Department of Biology, The University of Texas at Arlington, Arlington, Texas 76019, USA.
Smith
Ronald L
RL
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008969:Molecular Sequence Data; D016296:Mutagenesis / Q000502:physiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*; D015037:Zinc Radioisotopes
D001426:Bacterial Proteins; D002352:Carrier Proteins; D015037:Zinc Radioisotopes; D008274:Magnesium; D015032:Zinc