Increased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase.
In the present study, we flow cytometrically analyzed the intracellular production of interleukin (IL)-5 and IL-13 in peripheral blood CD4(+) and CD8(+) T cells from patients with multiple sclerosis (MS), human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and healthy controls. IL-13-producing T cells were significantly increased in both T cell subsets in MS at relapse, markedly in the conventional form of MS and modestly in the optocospinal form of MS, and returned to normal at remission. However, IL-5-producing T cells did not vary regardless of clinical phase or type. HAM/TSP showed no significant change in the number of IL-5- and IL-13-producing cells. A distinct profile of IL-13 and IL-5 production by disease and by phase of MS suggests an active involvement of these type 2 cytokines in central nervous system (CNS) inflammation.
Ochi
Hirofumi
H
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan
Osoegawa
Manabu
M
Wu
Xiao-Mu
XM
Minohara
Motozumi
M
Horiuchi
Izumi
I
Murai
Hiroyuki
H
Furuya
Hirokazu
H
Kira
Jun-ichi
J
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D018793:Interleukin-13 / Q000378:metabolism*; D015848:Interleukin-5 / Q000378:metabolism*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology*; D015493:Paraparesis, Tropical Spastic / Q000276:immunology; D012008:Recurrence
D018793:Interleukin-13; D015848:Interleukin-5