Cystic paracervical mass as an unusual sequela of graft-versus-host disease. A case report.
BACKGROUND
Bone marrow transplantation is used in the treatment of a variety of malignancies. One common sequela is graft-versus-host disease (GvHD.)


METHODS
A case of vaginal GvHD in a postmenopausal woman manifested as a 2-cm, cystic, paracervical mass. The patient was followed with consecutive pelvic ultrasounds and pelvic examinations until 27 months after transplantation, when the mass increased in size to 4 x 3 cm. Exploratory laparotomy with total abdominal hysterectomy revealed a 3 x 3-cm phlegmon within the proximal part of the vagina. Presumably, this resulted from vaginal GvHD, causing a midvaginal stricture with obstruction of cervical/uterine effluent.


CONCLUSIONS
An awareness of the gynecologic manifestations of GvHD is critical for clinicians caring for women undergoing bone marrow transplantation.
Gossett
Dana R
DR
Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Hospital and Medical Institutions, 600 North Wolfe Street, Phipps 281, Baltimore, MD 21287, USA.
Montz
F J
FJ
Bristow
Robert E
RE
D016026:Bone Marrow Transplantation; D003560:Cysts / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017698:Postmenopause; D014623:Vaginal Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery