Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting.
In an ongoing molecular epidemiology study, human immunodeficiency virus-negative patients with first-time pulmonary tuberculosis from a high-incidence community were enrolled. Mycobacterium tuberculosis strains were identified by restriction fragment length polymorphism analysis with two fingerprinting probes. Of 131 patients, 3 (2.3%) were shown to have a mixture of strains in one or two of their serial cultures. This study further investigated these cases with disease caused by multiple M. tuberculosis strains in the context of the molecular epidemiology of the study setting.
Richardson
Madalene
M
MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Carroll
Nora M
NM
Engelke
Erica
E
Van Der Spuy
Gian D
GD
Salker
Faeeza
F
Munch
Zahn
Z
Gie
Robert P
RP
Warren
Robin M
RM
Beyers
Nulda
N
Van Helden
Paul D
PD
D000328:Adult; D003470:Culture Media; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D014644:Genetic Variation; D006801:Humans; D015994:Incidence; D008297:Male; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012150:Polymorphism, Restriction Fragment Length; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology*
D003470:Culture Media; D004251:DNA Transposable Elements; D004269:DNA, Bacterial