title: [Goseki classification in adenocarcinoma of the cardia].
abstract: BACKGROUND
  To assess an additional prognostic value of Goseki histological classification to TNM staging system in adenocarcinoma of the cardia.
  
  
  METHODS
  Sixty-one patients curatively resected for advanced (T2, T3 and T4) cardia cancer at the I Division of General Surgery, University of Verona were classified in four different grades according to Goseki. Survival curves were estimated with Kaplan-Meier method and compared by the log-rank test. Multivariate analysis was performed by Cox regression model. c2 test was used to compare Goseki to Lauren classification and grading. After discharge from hospital all patients were followed with a mean follow-up of 39.5 months.
  
  
  RESULTS
  Lauren classification and grading were significantly related to tubular differentiation (p<0.01). Kaplan-Meier estimates of survival showed a better 5-year outcome for tumors with good tubular differentiation (19%), even though the difference with poor tubular differentiated tumors was not statistically significant (p'0.06). Diffuse type carcinomas and tumors with poor cytological differentiation showed a worse prognosis at univariate analysis (p<0.01). Multivariate analysis showed no additional prognostic significance of any of the histological classification analyzed. Only T (p<0.02; RR 2.2; IC 1.2-4) and N (p<0.01; RR 5; IC 2.4-11) were independent prognostic factors.
  
  
  CONCLUSIONS
  In adenocarcinoma of the cardia, Goseki classification did not add any information to Lauren classification and to TNM staging system.
authors.affiliation: I Divisione CLinicizzata di Chirurgia Generale, Università degli Studi, Verona, Italy. chirurgia.urgenza@univr.it
authors.forename: G
authors.initials: G
authors.lastname: De Manzoni
authors.forename: C
authors.initials: C
authors.lastname: Pedrazzani
authors.forename: A
authors.initials: A
authors.lastname: Di Leo
authors.forename: M
authors.initials: M
authors.lastname: Bonfiglio
authors.forename: G
authors.initials: G
authors.lastname: Zerman
authors.forename: S
authors.initials: S
authors.lastname: Tasselli
authors.forename: G
authors.initials: G
authors.lastname: Borzellino
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002299:Cardia / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000145:classification / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis; D013997:Time Factors