title: P6 acupoint injections are as effective as droperidol in controlling early postoperative nausea and vomiting in children.
abstract: BACKGROUND
  P6 acupuncture in adults is reported to be an effective preventive treatment for postoperative nausea and vomiting (PONV). It is not clear, however, whether this technique is effective as a preventive treatment for PONV in children.
  
  
  METHODS
  Children undergoing anesthesia and surgery were randomized to four groups: (a) intravenous saline + bilateral P6 acupoint injections (n = 50); (b) intravenous droperidol + bilateral P6 sham acupuncture (n = 49); (c) intravenous saline + bilateral sham point injections (n = 43); (d) intravenous saline +bilateral P6 sham acupuncture (n = 45). The perioperative anesthetic technique was standardized in all subjects. The incidence of postoperative nausea and vomiting (PONV) was evaluated in postanesthesia care unit (PACU) and 24 h after surgery.
  
  
  RESULTS
  Incidence of nausea in the PACU was significantly lower in the acupoint group as compared with the sham point group (32% vs. 56%, P = 0.029) and P6 sham group (32% vs. 64%, P = 0.002) but not as compared with the droperidol group (32% vs. 46%, P = ns). Similarly, subjects in the acupoint group had a significantly lower incidence of vomiting in the PACU as compared with the sham point group (12% vs. 33%, P = 0.026) and P6 sham group (12% vs. 31%, P = 0.029) but not as compared with the droperidol group (12% vs. 18%, P = ns). The combined incidence of early PONV was also lower in the acupoint group as compared with the sham point group (P = 0.045) and P6 sham group (P = 0.004) but not as compared with the droperidol group (42% vs. 51%, P = ns). Finally, significantly fewer subjects in the acupoint group required intravenous ondansetron as an initial rescue therapy (P = 0.024). At 24 h after surgery, however, the incidence of late PONV was similar among the four study groups (P = ns).
  
  
  CONCLUSIONS
  In children, P6 acupoint injections are as effective as droperidol in controlling early postoperative nausea and vomiting.
authors.affiliation: Department of Anesthesiology, Pediatrics, and Child and Adolescent Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520-8051, USA. shu-ming@yale.edu
authors.forename: Shu-Ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Zeev N
authors.initials: ZN
authors.lastname: Kain
mesh_terms: D026881:Acupuncture / Q000379:methods*; D000293:Adolescent; D000768:Anesthesia, General; D000932:Antiemetics / Q000627:therapeutic use*; D002648:Child; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy* / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D004329:Droperidol