title: Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease.
abstract: Serotonin1A receptor density and serotonin concentration were measured in the postmortem neocortex of 17 AD patients who had been prospectively assessed every four months with the Mini-Mental State Examination (MMSE) for a mean of 2.6 years till death. In the frontal cortex, serotonin levels correlated negatively with the annual rate of MMSE decline, while serotonin1A receptor density was positively correlated with the rate of MMSE decline. Our study suggests that reduced serotonin levels and increased serotonin1A receptor density are markers for accelerated cognitive decline in AD, and provides support for the use of serotonin1A antagonists in the treatment of AD.
authors.affiliation: Department of Pharmacology, University of Sydney, NSW 2006, Australia.
authors.forename: Mitchell K P
authors.initials: MK
authors.lastname: Lai
authors.forename: Shirley W Y
authors.initials: SW
authors.lastname: Tsang
authors.forename: Paul T
authors.initials: PT
authors.lastname: Francis
authors.forename: Janet
authors.initials: J
authors.lastname: Keene
authors.forename: Tony
authors.initials: T
authors.lastname: Hope
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Esiri
authors.forename: Ian
authors.initials: I
authors.lastname: Spence
authors.forename: Christopher P L-H
authors.initials: CP
authors.lastname: Chen
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D003072:Cognition Disorders / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D018450:Disease Progression; D015536:Down-Regulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D019579:Neocortex / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists; D012737:Sex Factors
chemical_list: D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin