Influence of the drying technique on theophylline pellets prepared by extrusion-spheronization.
Extrusion-spheronization is frequent method for pellet production and especially extrusion stage has been studied for its influence on pellet properties. However, the formation of pellet structure is not finished before drying stage. The possible influence of different drying methods and used temperatures on some properties of pellets, containing theophylline as active ingredient and Avicel CL-611 as spheronizing agent, is the object of this paper.
Pérez
J
J
Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42, Brno, Czech Republic.
Rabisková
M
M
D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000737:chemistry; D002482:Cellulose; D003890:Desiccation / Q000379:methods; D004339:Drug Compounding / Q000379:methods*; D005079:Excipients; D006244:Hardness; D010316:Particle Size; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry
D001993:Bronchodilator Agents; D005079:Excipients; D002482:Cellulose; D013806:Theophylline