title: Maternal and foetal activin A levels: associations with normal and abnormal labour.
abstract: In pregnancy the feto-placental unit is the major source of activin A. However, the role(s) of activin A in late pregnancy remain uncertain and controversial. In particular, whether activin A levels alter in association with labour is unclear. In a cross-sectional cohort study, maternal serum samples were collected from women at term prior to elective Caesarean section (n=11), during labour prior to a spontaneous vaginal delivery (n=31), an instrumental vaginal delivery (n=16) or an emergent Caesarean section (n=7). Umbilical artery blood samples were collected from 75 pregnancies, after an elective Caesarean section (n=9), a normal vaginal delivery (n=37), an instrumental vaginal delivery (n=15) or an emergent Caesarean section (n=14). Levels of activin A were measured and compared according to modes of delivery. Maternal, but not foetal, serum activin A was increased significantly in women who were delivered by an intrapartum Caesarean section compared to other modes of delivery. Foetal, but not maternal, serum activin A was significantly correlated with umbilical artery pH. Maternal serum activin A is increased in women undergoing an intrapartum Caesarean section compared to either a vaginal delivery or an elective Caesarean section. The mechanism(s) underlying this observation are not clear.
authors.affiliation: Centre for Women's Health Research, Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
authors.forename: M E
authors.initials: ME
authors.lastname: Schneider-Kolsky
authors.forename: S
authors.initials: S
authors.lastname: Tong
authors.forename: E M
authors.initials: EM
authors.lastname: Wallace
mesh_terms: D028341:Activins / Q000097:blood*; D002585:Cesarean Section; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D028322:Inhibin-beta Subunits / Q000097:blood*; D007744:Obstetric Labor Complications / Q000097:blood*; D011247:Pregnancy; D014469:Umbilical Arteries
chemical_list: C422405:activin A; D028341:Activins; D028322:Inhibin-beta Subunits