Quinoline alkaloids, coumarins and volatile constituents of Helietta longifoliata.
A new quinoline alkaloid named helietidine ( 1), and seven known compounds ( 2 - 8) have been isolated from the stem barks of Helietta longifoliata. The structures of the new and the known compounds were established on the basis of spectral evidence, especially by 2D NMR ( 1H- 1H COSY, NOESY, HMQC, HMBC). In addition, the volatile constituents of H. longifoliata leaves were analysed by gas chromatography-mass spectrometry (GC-MS). Twenty-five constituents were identified representing ca. of 96 % of the oil, and limonene (17.50 %), germacrene D (16.60 %), elemol (11.81 %), bicyclogermacrene (11.67 %), guaiol (11.53), and epi-alpha-bisabolol (7.24 %) were the most abundant components. The oil was bioactive against some Gram-positive and Gram-negative bacteria, as revealed by bioautography.
de Moura
Neusa F
NF
Departamento de Química, Universidade Federal de Santa Maria, RS, Brazil.
Simionatto
Euclésio
E
Porto
Carla
C
Hoelzel
Solange C
SC
Dessoy
Emilia C
EC
Zanatta
Nilo
N
Morel
Ademir F
AF
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*; D013210:Staphylococcus / Q000187:drug effects
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D003374:Coumarins; D011804:Quinolines; C464950:helietidine