The importance of growth hormone (GH) and GH secretagogues for bone mass and density.
Potent antiresorptive agents have been developed for the treatment of osteoporosis and bone disorders. There are few agents available that stimulate bone formation. Recently, treatment with parathyroid hormone was found to induce a potent increase in hip and lumbar bone mineral density (BMD). The present review focus on growth hormone (GH)/ growth hormone secretagogues (GHSs). GH/GHSs stimulates bone turnover, thereby increasing bone mass and density.
Svensson
Johan
J
Research Centre for Endocrinology and Metabolism, Gröna Sträket 8, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden. Johan.Svensson@medic.gu.se
D000172:Acromegaly / Q000188:drug therapy; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001846:Bone Development / Q000187:drug effects; D001847:Bone Diseases / Q000188:drug therapy* / Q000503:physiopathology; D001862:Bone Resorption / Q000188:drug therapy / Q000503:physiopathology; D001842:Bone and Bones / Q000187:drug effects* / Q000502:physiology; D050723:Fractures, Bone / Q000503:physiopathology / Q000517:prevention & control; D013006:Growth Hormone / Q000378:metabolism* / Q000494:pharmacology* / Q000627:therapeutic use; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy / Q000517:prevention & control; D011986:Receptors, Somatotropin / Q000378:metabolism
D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D013006:Growth Hormone