The importance of patient-specific radiation dose calculations for the administration of radionuclides in therapy.
This paper advocates patient-specific approaches to radiation dose calculations for radionuclides used in therapy and outlines strategies for implementing such approaches. The use of a simple approaches to radionuclide therapy, e.g. a single amount of activity for all patients or the same amount of activity administered per unit body weight do not permit the optimization of individual patient therapy. While limitations in current models and logistic problems prevent dose calculations of the quality currently enjoyed with external radiation therapy approaches, improvements can be made, and models are constantly evolving. Specific suggestions regarding the extension of current models, and of the use of new models which use image data from individual patients, are discussed in the context of allowing radiotherapy with internal emitters to employ the kind of patient-specific approaches that are used in other therapeutic modalities, which are clearly in the patients' best interests.
Siegel
Jeffry A
JA
Nuclear Physics Enterprises, Cherry Hill, NJ, USA.
Stabin
Michael G
MG
Brill
A Bertrand
AB
D001853:Bone Marrow / Q000528:radiation effects; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy; D011868:Radioisotopes / Q000008:administration & dosage / Q000592:standards / Q000633:toxicity; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000592:standards / Q000633:toxicity; D011879:Radiotherapy Dosage / Q000592:standards
D011868:Radioisotopes; D019275:Radiopharmaceuticals