Severe periodontitis in Marfan's syndrome: a case report.
BACKGROUND
Connective tissue disorders, such as some forms of Ehlers-Danlos syndrome, have been associated with severe periodontitis.


METHODS
This report describes a case of Marfan's syndrome, an inherited disorder of connective tissue caused by mutations in the fibrillin-1 gene, in which the patient presented with severe periodontitis.


RESULTS
At examination, an average full-mouth clinical attachment level loss of 5.6+/-2.1 mm, furcation involvement, and severe alveolar bone loss were observed in a 41-year-old Caucasian male. Tooth hypermobility was also present.


CONCLUSIONS
This case appears to be the first documentation of severe periodontitis in a patient with Marfan's syndrome. It supports the hypothesis that a variety of connective tissue disorders may confer increased susceptibility to periodontal tissue breakdown.
Straub
Antje M
AM
Department of Periodontology, Eastman Dental Institute, University College, London, UK.
Grahame
Rodney
R
Scully
Crispian
C
Tonetti
Maurizio S
MS
D000328:Adult; D002908:Chronic Disease; D000071838:Fibrillin-1; D000071837:Fibrillins; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications*; D008840:Microfilament Proteins / Q000235:genetics; D010518:Periodontitis / Q000209:etiology*; D054392:Adipokines
D000071838:Fibrillin-1; D000071837:Fibrillins; D008840:Microfilament Proteins; C000605722:FBN1 protein, human; D054392:Adipokines