Overlapping and specific patterns of GDNF, c-ret and GFR alpha mRNA expression in the developing chicken retina.
GDNF and the GDNF receptors, c-Ret, GFR alpha 1 and 2 mRNA is expressed in the developing chicken retina. GDNF labelling was mainly found in embryonic day 4-5 retina but weak labelling could also be found over scattered retinal cells at later stages. c-ret labelling was found over ganglion cells, amacrine and horizontal cells; the preferred GDNF receptor (GFR alpha 1) over amacrine and horizontal cells; and the less preferred GDNF receptor (GFR alpha 2) over ganglion cells, amacrine cells and photoreceptors.
Karlsson
Miriam
M
Department of Neuroscience, Uppsala University, Box 587, 751 23, Uppsala, Sweden.
Lindqvist
Niclas
N
Mayordomo
Raquel
R
Hallböök
Finn
F
D000818:Animals; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D029721:Drosophila Proteins; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D017403:In Situ Hybridization; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D051101:Neurturin; D010786:Photoreceptor Cells / Q000196:embryology; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D012333:RNA, Messenger / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D012160:Retina / Q000196:embryology*; D015398:Signal Transduction; D013997:Time Factors
D029721:Drosophila Proteins; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D009414:Nerve Growth Factors; D051101:Neurturin; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila