title: Rat visual cortical neurones express TrkA NGF receptor.
abstract: In this study we report the expression of TrkA receptor within the rat visual cortex during postnatal development and in adulthood, using a specific monoclonal antibody which recognizes the extracellular domain of TrkA receptor. TrkA was not detected by immunohistochemistry at postnatal day 13 (P13), i.e. before eye opening. At P22 TrkA was mostly localised in cortical fibre-like processes. At P39 and P90, TrkA-positive neuronal cell bodies in supragranular and infragranular layers were found. Using double immunohistochemistry, labelled cells were identified as intrinsic cholinergic neurones, and as interneurones expressing calbindin and neuropeptide Y. We conclude that TrkA is expressed in visual cortical neurones during postnatal development and in adulthood and that its pattern of expression is developmentally regulated.
authors.affiliation: Cognitive Neuroscience Sector, Neuroscience Program, International School for Advanced Studies (SISSA), Via Beirut 2-4, 34014 Trieste, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Tropea
authors.forename: Simona
authors.initials: S
authors.lastname: Capsoni
authors.forename: Sonia
authors.initials: S
authors.lastname: Covaceuszach
authors.forename: Luciano
authors.initials: L
authors.lastname: Domenici
authors.forename: Antonino
authors.initials: A
authors.lastname: Cattaneo
mesh_terms: D000367:Age Factors; D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D003423:Critical Period, Psychological; D007150:Immunohistochemistry; D009474:Neurons / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D020917:Receptor, trkA / Q000032:analysis* / Q000276:immunology; D014793:Visual Cortex / Q000166:cytology* / Q000254:growth & development
chemical_list: D000911:Antibodies, Monoclonal; D020917:Receptor, trkA