title: Hypersensitivity reactions to carboplatin in children.
abstract: Hypersensitivity reactions to carboplatin are rare but sometimes life-threatening events may occur requiring discontinuation of treatment. In our study, we describe clinical features and diagnostic procedures of carboplatin-associated reactions in children affected by low-grade astrocytoma and treated with multiple courses of carboplatin. In 6 out of 29 children, we reported allergic events. We also report a desensitization protocol for carboplatin administration, which allowed the patients to receive effective treatment without adverse reactions.
authors.affiliation: Division of Pediatric Oncology, Catholic University of Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lazzareschi
authors.forename: Antonio
authors.initials: A
authors.lastname: Ruggiero
authors.forename: Riccardo
authors.initials: R
authors.lastname: Riccardi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Attinà
authors.forename: Cesare
authors.initials: C
authors.lastname: Colosimo
authors.forename: Anna
authors.initials: A
authors.lastname: Lasorella
mesh_terms: D018926:Anti-Allergic Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001254:Astrocytoma / Q000175:diagnosis / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D002744:Chlorpheniramine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D002744:Chlorpheniramine; D016190:Carboplatin; D006854:Hydrocortisone; D004837:Epinephrine