Morphologic and morphometric analyses of acetic acid-induced colitis in rats after treatment with enemas from Myracrodruon urundeuva Fr. All. (Aroeira do Sertão).
The present work showed the effects of Myracrodruon urundeuva Fr. All., popularly known as 'aroeira' (AE), in the form of enemas prepared from the stem bark, on several morphologic and morphometric parameters after acetic acid-induced colitis in rats. Enemas from 5-ASA were used as standard while the vehicle, carboxymethylcellulose, was used as a control. The results of the morphological evaluation showed that on day 1 acetic acid produced significantly more necrosis in the groups treated with AE (10% and 20%) or 5-ASA than the controls. However, on day 60, there were more caliciform and absorptive cells in the treated groups compared with the controls. A significantly higher number of eosinophil and mononuclear cells and also collagen deposition in the controls compared with the treated groups were observed on day 60. However, a higher number of polymorphonuclear cells was detected on day 60 only in the AE treated group but not in the 5-ASA group. These data indicate that animals treated with AE or 5-ASA showed complete epithelial tissue regeneration, while in the controls chronic inflammatory exudate persisted and tissue regeneration occurred through fibrosis.
Rodrigues
Lusmar Veras
LV
Department of Surgery, Federal University of Ceará, Fortaleza, Brazil.
Ferreira
Francisco Valdeci
FV
Regadas
F Sérgio P
FS
Matos
Délcio
D
Viana
Glauce Socorro de Barros
GS
D019342:Acetic Acid / Q000633:toxicity; D027926:Anacardiaceae; D000818:Animals; D001938:Brazil; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000166:cytology / Q000187:drug effects; D004733:Enema / Q000379:methods*; D004804:Eosinophils / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009336:Necrosis; D009504:Neutrophils / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D003094:Collagen; D019342:Acetic Acid