title: Prognostic factors of gastrointestinal stromal tumors.
abstract: Gastrointestinal stromal tumors (GIST) are rare neoplasms of unknown etiology and pathogenesis. Their clinical behavior is very unpredictable and a reliable prognostic factor is lacking. The aim of this study was to analyze some prognostic factors and estimate which one is the most reliable. Thirty-eight biopsy specimens of GIST were immunolabeled for PCNA, CD34, vimentin, NSE and actin. The greatest diameter, histological grading, mitotic count, DNA-index and S-phase were estimated for each case. All patients were followed-up for at least 24 months or to death. The data were analysed by univariate and multivariate statistical analysis using a computer program. The results showed that greatest diameter, tumor grade, mitotic count and PCNA-index are prognostic factors in univariate analysis. In multivariate analysis only the greatest diameter is a useful prognostic factor for planning further therapy.
authors.affiliation: Department of Pathology, Rijeka University School of Medicine, Croatia. drazen.kovac@medri.hr
authors.forename: Drazen
authors.initials: D
authors.lastname: Kovac
authors.forename: Mladen
authors.initials: M
authors.lastname: Petrovecki
authors.forename: Mladen
authors.initials: M
authors.lastname: Jasic
authors.forename: Renata
authors.initials: R
authors.lastname: Dobi-Babic
authors.forename: Nikola
authors.initials: N
authors.lastname: Ivanis
authors.forename: Milivoj
authors.initials: M
authors.lastname: Rubinic
authors.forename: Simun
authors.initials: S
authors.lastname: Krizanac
authors.forename: Nives
authors.initials: N
authors.lastname: Jonjic
authors.forename: Clara
authors.initials: C
authors.lastname: Rizzardi
authors.forename: Mauro
authors.initials: M
authors.lastname: Melato
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D015996:Survival Rate; D014746:Vimentin / Q000096:biosynthesis
chemical_list: D014746:Vimentin