Shmoos, rafts, and uropods- the many facets of cell polarity.
The recent Juan March Foundation meeting on "Regulation and functional insights in cellular polarity" focused on cellular polarity in yeasts, Dictyostelium, epithelial cells, fibroblasts, and immune cells. The molecular systems covered included membrane rafts, actin and tubulin cytoskeleton, polarized transcription, signaling, and cell-cell adhesion. Across these diverse biological and molecular systems, important general concepts emerged, including new ideas for establishing and maintaining polarity that are likely to be applicable across models and experimental systems.
Dustin
Michael L
ML
Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA. dustin@saturn.med.nyu.edu
D000199:Actins / Q000502:physiology*; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology*; D003593:Cytoplasm / Q000502:physiology; D006801:Humans; D008563:Membrane Lipids / Q000502:physiology; D008566:Membranes / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014404:Tubulin / Q000502:physiology*; D020744:rac GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology
D000199:Actins; D008563:Membrane Lipids; D014404:Tubulin; D020744:rac GTP-Binding Proteins