title: Coronary Doppler measurements do not predict progression of cardiac allograft vasculopathy: analysis by serial intracoronary Doppler, dobutamine stress echocardiography, and intracoronary ultrasound.
abstract: Coronary flow velocity reserve (CFVR) (maximum/baseline flow velocity, 16 microg adenosine) was compared with dobutamine stress echocardiography (DSE) (5 to 40 microg/kg/min) to assess the progression of angiographically silent cardiac allograft vasculopathy (CAV). As a reference for the morphologic assessment of CAV, serial intracoronary ultrasound (ICUS) measurements were performed. An increase in CFVR could be observed in all transplant patients despite morphologic or functional progression of CAV or non-progressive CAV as assessed by ICUS or DSE. Thus, serial intracoronary Doppler flow analysis is not useful to predict morphologic or functional progression of CAV.
authors.affiliation: Department of Cardiology, Medizinische Klinik-Innenstadt, University of Munich, Germany. andreas.koenig@medinn.med.uni-muenchen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: König
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Spes
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Schiele
authors.forename: Johannes
authors.initials: J
authors.lastname: Rieber
authors.forename: Hans U
authors.initials: HU
authors.lastname: Stempfle
authors.forename: Bruno
authors.initials: B
authors.lastname: Meiser
authors.forename: Karl
authors.initials: K
authors.lastname: Theisen
authors.forename: Harald
authors.initials: H
authors.lastname: Mudra
authors.forename: Bruno
authors.initials: B
authors.lastname: Reichart
authors.forename: Volker
authors.initials: V
authors.lastname: Klauss
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D018450:Disease Progression; D015150:Echocardiography, Doppler; D025401:Echocardiography, Stress; D016027:Heart Transplantation; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D018084:Ultrasonography, Interventional