title: Ramosetron for the prevention of cisplatin-induced acute emesis: a prospective randomized comparison with granisetron.
abstract: Control of nausea and vomiting is very important in determining patient compliance with cisplatin chemotherapy. A multicentre, randomized, single-blind study was conducted to compare the tolerability and efficacy of ramosetron with those of granisetron over 24 h following cisplatin administration to cancer patients. In eight study centres, a total of 194 adult patients were randomly assigned to receive either intravenous ramosetron 0.3 mg or intravenous granisetron 3.0 mg. The anti-emetic effect of ramosetron determined from the no-vomiting rate lasted longer, but there was no significant difference in the number of acute vomiting episodes or the severity of nausea between the two groups. In the tolerability evaluation, there were no statistically significant differences between the two groups, except for a higher incidence of dull headache in the granisetron group. Ramosetron and granisetron appear to have equivalent efficacy and tolerability profiles, but the effects of ramosetron on the prevention of acute vomiting in patients undergoing cisplatin chemotherapy were longer lasting.
authors.affiliation: Department of Internal Medicine, Korea Cancer Centre Hospital, Seoul, Korea. ykkang@amc.seoul.kr
authors.forename: Y K
authors.initials: YK
authors.lastname: Kang
authors.forename: Y H
authors.initials: YH
authors.lastname: Park
authors.forename: B Y
authors.initials: BY
authors.lastname: Ryoo
authors.forename: Y J
authors.initials: YJ
authors.lastname: Bang
authors.forename: K S
authors.initials: KS
authors.lastname: Cho
authors.forename: D B
authors.initials: DB
authors.lastname: Shin
authors.forename: H C
authors.initials: HC
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: Y S
authors.initials: YS
authors.lastname: Park
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
authors.forename: D S
authors.initials: DS
authors.lastname: Heo
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: E K
authors.initials: EK
authors.lastname: Cho
authors.forename: H Y
authors.initials: HY
authors.lastname: Lim
authors.forename: W K
authors.initials: WK
authors.lastname: Kim
authors.forename: J A
authors.initials: JA
authors.lastname: Lee
authors.forename: T Y
authors.initials: TY
authors.lastname: Kim
authors.forename: J C
authors.initials: JC
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Yoon
authors.forename: N K
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000855:Anorexia / Q000517:prevention & control; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D016037:Single-Blind Method; D014839:Vomiting / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D002945:Cisplatin; D017829:Granisetron; D012702:Serotonin Antagonists; C071315:ramosetron