title: Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer.
abstract: A very long half-life of paroxetine (195 h instead of the usual value of around 16 h) was measured after an overdose with 2 g paroxetine and 1 g clorazepate in a patient who was an extensive cytochrome P4502D6 metabolizer. The patient recovered well without any clinically significant complications. A consequence of the close monitoring of paroxetine levels in this patient was that it was decided not to reintroduce any other antidepressant despite her suicide attempt, until normal levels of paroxetine had been reached, which took over 1 month.
authors.affiliation: University Department of Psychiatry, Belle-Idée, Chêne-Bourg, Geneva, Switzerland.
authors.forename: Henriette
authors.initials: H
authors.lastname: Hilleret
authors.forename: Pierre
authors.initials: P
authors.lastname: Voirol
authors.forename: Philippe
authors.initials: P
authors.lastname: Bovier
authors.forename: Panteleimon
authors.initials: P
authors.lastname: Giannakopoulos
authors.forename: Daniele
authors.initials: D
authors.lastname: Zullino
authors.forename: Pierre
authors.initials: P
authors.lastname: Baumann
authors.forename: Christian
authors.initials: C
authors.lastname: Giroud
authors.forename: Laurent
authors.initials: L
authors.lastname: Rivier
authors.forename: Chin B
authors.initials: CB
authors.lastname: Eap
mesh_terms: D014151:Anti-Anxiety Agents / Q000378:metabolism* / Q000506:poisoning; D018687:Antidepressive Agents, Second-Generation / Q000378:metabolism* / Q000506:poisoning; D001007:Anxiety / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D003009:Clorazepate Dipotassium / Q000378:metabolism / Q000506:poisoning; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D004347:Drug Interactions; D062787:Drug Overdose; D005260:Female; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D017374:Paroxetine / Q000378:metabolism* / Q000506:poisoning; D013406:Suicide, Attempted
chemical_list: D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine; D003009:Clorazepate Dipotassium; D019389:Cytochrome P-450 CYP2D6