Submicronparticles from biodegradable polymers.
The objective was to prepare small particles in the nm range with poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) applying the spontaneous emulsification process. Polymer parameters as well as process parameters were investigated. The results show that spontaneous emulsification is a simple method to produce small particles in the 200-1000 nm range. A major drawback is the limitation to very restricted conditions, e.g. molecular weight up to 30.000 g/mole, glycolide content in the copolymer up to 30 mole% and concentration of the polymer solution lower than or equal to 1% (w/v).
Jobmann
Monika
M
Fraunhofer-Institut für Angewandte Polymerforschung, Geiselbergstrasse 69, 14476, Golm, Germany. jobmann@iap.fhg.de
Rafler
Gerald
G
D001673:Biodegradation, Environmental; D004355:Drug Stability; D004655:Emulsions; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D008970:Molecular Weight; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*
D004655:Emulsions; D011091:Polyesters; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)