title: Dexamethazone-induced acute tumor lysis syndrome in a T-cell malignant lymphoma.
abstract: We report a case of steroid-induced acute tumor lysis syndrome and review the literature. A 60-year-old woman was started on steroid therapy for dyspnea due to bilateral pleural effusion and a large mass involving the anterior mediastinum. The final diagnosis was precursor T-lymphoblastic lymphoma-leukemia. Following steroid therapy, the patient developed acute renal failure and laboratory evidence of metabolic changes induced by massive cytolysis. She received vigorous hydration, diuretic and allopurinol therapy, and haemodialysis. Her diuresis, renal function and laboratory data returned to normal within 2 weeks. A review of the medical literature on T-cell lymphoma revealed only one similar case of steroid-induced acute tumor lysis syndrome, a life-threatening metabolic emergency. This risk should be kept into account in the management of patients with lymphoproliferative disorders.
authors.affiliation: Department of Internal Medicine, University of Genoa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Lerza
authors.forename: M
authors.initials: M
authors.lastname: Botta
authors.forename: B
authors.initials: B
authors.lastname: Barsotti
authors.forename: E
authors.initials: E
authors.lastname: Schenone
authors.forename: M
authors.initials: M
authors.lastname: Mencoboni
authors.forename: G
authors.initials: G
authors.lastname: Bogliolo
authors.forename: I
authors.initials: I
authors.lastname: Pannacciulli
authors.forename: E
authors.initials: E
authors.lastname: Arboscello
mesh_terms: D000208:Acute Disease; D003907:Dexamethasone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy*; D008875:Middle Aged; D015275:Tumor Lysis Syndrome / Q000209:etiology*
chemical_list: D003907:Dexamethasone