[Healing of gastric mucosal erosions induced by indomethacin and restoration of glucocorticoids levels in the blood of rats].
The study was made of the effects of low production of glucoorticoids and subsequent replacement with these hormones on healing of hemorrhagic erosions of rat gastric mucosa emerging 4 hours after administration of indomethacin (25 mg/kg percutaneously). Corticosteroid deficiency was produced by adrenalectomy or blocking function of the hypothalamo-hypophyseo-adrenocortical system by introduction of supraphysiological dose of hydrocortisone i week before indomethacin administration. Replacement therapy was conducted 4 hours after indomethacine administration by subcutaneous injection of corticosterone in a dose of 4 mg/kg. Healing was evaluated by changes in the area of damaged surface of gastric mucosa for 2 days after indomethacin administration. Plasma levels of corticosteroids were controlled. It was found that animals with corticosteroid deficiency had a larger area of mucosal lesion and slow healing vs control rats. Administration of corticosterone in physiological dose to animals with deficient production of corticosteroids stimulated healing of gastric mucosa erosions.
Podvigina
T T
TT
Bogdanov
A I
AI
Filaretova
L P
LP
D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000097:blood; D006854:Hydrocortisone / Q000494:pharmacology; D007213:Indomethacin; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D005938:Glucocorticoids; D003345:Corticosterone; D006854:Hydrocortisone; D007213:Indomethacin