Mechanisms of immune privilege for tumor cells by regulatory cytokines produced by innate and acquired immune cells.
In murine tumors, innate immunity act as a trigger for the development of acquired immunity. The innate immune cells, natural killer (NK) and natural T (NKT) cells, generate the acquired immune cells, cytotoxic T lymphocytes (CTLs) and T helper (Th) 1 cells, by releasing interferon (IFN)-gamma. Regulatory T cells co-infiltrate with these tumoricidal effectors. In the innate phase, T cell receptor (TCR) gammadelta-bearing T (gammadelta T) and TCRalphabeta intermediate T cells are the regulators that suppress NK and NKT cells by elaborating interleukin (IL)-4, IL-10 and transforming growth factor (TGF)-beta. The acquired phase has Th3/T regulatory 1-like cells that inhibit CTLs and Th1 cells by TGF-beta. Thus, cytokines from regulatory T cells exert profound effects on tumor growth.
Seo
Naohiro
N
Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handa-Yama, Hamamatsu, Shizuoka 431-3192, Japan. seo445@hama-med.ac.jp
Hayakawa
Satoshi
S
Tokura
Yoshiki
Y
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines