Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease.
Neuronal intranuclear rodlets were described in normal brain over a century ago, but their functional significance and pathological relevance is unknown. Here, we show co-localization of tubulin and glucocorticoid receptor-like immunoreactivity in these intranuclear inclusions in human brain. In addition, we provide evidence for a massive reduction in their areal density in Alzheimer's disease brain, but not in another common neurodegenerative condition, dementia with Lewy bodies. The marked reduction of these inclusions in Alzheimer's disease may support the concept of a role for stress hormones in Alzheimer's pathogenesis.
Woulfe
John M
JM
Department of Pathology and Laboratory Medicine, The University of Ottawa, The Ottawa Hospital, Ontario, Canada. jwoulfe@ottawahospital.on.ca
Hammond
Robert
R
Richardson
Bryan
B
Sooriabalan
Danushan
D
Parks
William
W
Rippstein
Peter
P
Munoz
David G
DG
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D016022:Case-Control Studies; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000648:ultrastructure*; D020961:Lewy Body Disease / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D019636:Neurodegenerative Diseases / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013347:Subcellular Fractions / Q000648:ultrastructure; D014404:Tubulin / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D014404:Tubulin