title: Congenital estrogen deficiency in men: a new syndrome with different phenotypes; clinical and therapeutic implications in men.
abstract: The report focuses on the role of estrogens in human male, dealing with two human models of congenital estrogen deficiency: estrogen resistance and aromatase deficiency. Similarities and differences of clinical phenotypes of these models are described and progresses of estrogen treatment of aromatase-deficient men are reported. Finally, the putative use of estrogen in men and the use of aromatase inhibitors and antiestrogen for male disorders are discussed.
authors.affiliation: Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo, 71, 41100 Modena, Italy. rochira.vincenzo@unimo.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rochira
authors.forename: Antonio
authors.initials: A
authors.lastname: Balestrieri
authors.forename: Bruno
authors.initials: B
authors.lastname: Madeo
authors.forename: Antonio
authors.initials: A
authors.lastname: Spaggiari
authors.forename: Cesare
authors.initials: C
authors.lastname: Carani
mesh_terms: D001141:Aromatase / Q000172:deficiency; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D047628:Estrogen Receptor alpha; D004967:Estrogens / Q000172:deficiency* / Q000502:physiology / Q000627:therapeutic use; D006130:Growth Disorders / Q000188:drug therapy; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000188:drug therapy; D008954:Models, Biological; D010641:Phenotype; D011960:Receptors, Estrogen / Q000172:deficiency; D013577:Syndrome
chemical_list: D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D047628:Estrogen Receptor alpha; D004967:Estrogens; D011960:Receptors, Estrogen; D001141:Aromatase