title: DiffTool: building, visualizing and querying protein clusters.
abstract: DiffTool is a resource to build and visualize protein clusters computed from a sequence database. The package provides a clustering tool to construct protein families according to sequence similarities and a web interface to query the corresponding clusters. A subtractive genome analysis tool selects protein families specific for a genome or a group of genomes. For each protein cluster, DiffTool includes access to sequences, coloured multiple alignments and phylogenetic trees.
  
  
  BACKGROUND
  A cluster database built from yeast and complete prokaryotic genomes is queryable at http://bioweb.pasteur.fr/seqanal/difftool. All the Perl sources are freely available to non-profit organizations upon request.
authors.affiliation: Laboratoire Génomique des Microorganismes Pathogénes, Institut Pasteur, Département de Biologie Moléculaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France. fchetou@infobiogen.fr
authors.forename: Farid
authors.initials: F
authors.lastname: Chetouani
authors.forename: Philippe
authors.initials: P
authors.lastname: Glaser
authors.forename: Frank
authors.initials: F
authors.lastname: Kunst
mesh_terms: D016000:Cluster Analysis; D003196:Computer Graphics; D003628:Database Management Systems; D030562:Databases, Protein; D016678:Genome; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D016415:Sequence Alignment / Q000379:methods; D020539:Sequence Analysis, Protein / Q000379:methods*; D017385:Sequence Homology; D012984:Software