[Is insertion/deletion polymorphism angiotensin-converting enzyme gene responsible for long-life?].
I/D polymorphism of ACE gene is the most frequent examined polymorphism and probably very strongly connected to pathology. The majority of studies describe negative influence of allele D on frequency and course of given diseases. The result of negative effect of this allele should be visible in people with long life expectancy. To answer the question: is I/D polymorphism ACE gene responsible for long-life, a comparison was made of the genotype map of a group of 101 long-life subjects with a group of 494 younger persons. The examination used polymerase chain reaction methods. The results were calculated using the programme Statistica 5.1 PL. One used the independent chi 2 test and Odds Ratio to compare the genotype map and localisation of alleles. After having made comparative examination no connection was made between I/D polymorphism ACE gene and long-life.
Grzeszczak
Władysław
W
Katedra i Klinika Chorób Wewnetrznych, Diabetologii Wydziału Lekarskiego w Zabrzu,  Slaskiej Akademii Medycznej, 41-800 Zabrze, ul. 3 Maja 13/15.
Misztalski
Tomasz
T
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D017353:Gene Deletion; D015971:Gene Expression Regulation, Enzymologic; D005838:Genotype; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A