Inhibition of IL-12 signaling Stat4/IFN-gamma pathway by rapamycin is associated with impaired dendritic [correction of dendritc] cell function.
Chiang
P-H
PH
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15261, USA.
Wang
L
L
Liang
Y
Y
Liang
X
X
Qian
S
S
Fung
J J
JJ
Bonham
C A
CA
Lu
L
L
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology*; D005434:Flow Cytometry / Q000379:methods; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D016027:Heart Transplantation / Q000276:immunology; D007371:Interferon-gamma / Q000037:antagonists & inhibitors*; D018664:Interleukin-12 / Q000037:antagonists & inhibitors*; D051379:Mice; D008809:Mice, Inbred C3H; D050797:STAT4 Transcription Factor; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*; D020123:Sirolimus / Q000494:pharmacology*; D015534:Trans-Activators / Q000037:antagonists & inhibitors*
D004268:DNA-Binding Proteins; D050797:STAT4 Transcription Factor; C494091:Stat4 protein, mouse; D015534:Trans-Activators; D018664:Interleukin-12; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D020123:Sirolimus