Parasympathetic nervous system modulates effects of hyperpolarization-activated channel blockade.
Bilateral vagotomy eliminating extracardiac parasympathetic influences on the heart modulates the changes in variational pulsogram during blockade of hyperpolarization-activated currents, but has no significant effect on stroke volume after the blockade.
Ziyatdinova
N I
NI
Department of Normal Physiology, Kazan State Medical University.
Zefirov
T L
TL
D000818:Animals; D001919:Bradycardia / Q000209:etiology / Q000503:physiopathology; D002317:Cardiovascular Agents / Q000494:pharmacology; D054815:Cyclic Nucleotide-Gated Cation Channels; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000037:antagonists & inhibitors*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D015221:Potassium Channels; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D013318:Stroke Volume / Q000187:drug effects; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
D002317:Cardiovascular Agents; D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D015221:Potassium Channels; D011743:Pyrimidines; C082246:ICI D2788