Histamine-dependent changes in free radical processes during coronary heart disease.
Histamine is involved in the pathogenesis of coronary heart disease, intensifies generation of reactive oxygen species by blood leukocytes, and causes mobilization followed by exhaustion of antioxidant reserves. The prooxidant effect of histamine on free radical processes in patients with coronary heart disease determines the rate of recurrences and is associated with poorer prognosis and more severe course of the disease.
Stremoukhov
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Department of Internal Diseases No 2, Therapeutic Faculty, I. M. Sechenov Moscow Medical Academy.
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology; D003327:Coronary Disease / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005609:Free Radicals; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000494:pharmacology; D011379:Prognosis; D017382:Reactive Oxygen Species; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals; D016877:Oxidants; D017382:Reactive Oxygen Species; D006632:Histamine