Monocarboxylate transporters and lactate metabolism in equine athletes: a review.
Lactate is known as the end product of anaerobic glycolysis, a pathway that is of key importance during high intensity exercise. Instead of being a waste product lactate is now regarded as a valuable substrate that significantly contributes to the energy production of heart, non-contracting muscles and even brain. The recent cloning of monocarboxylate transporters, a conserved protein family that transports lactate through biological membranes, has given a new insight into the role of lactate in whole body metabolism. This paper reviews current literature on lactate and monocarboxylate transporters with special reference to horses.
Pösö
A R
AR
Department of Basic Veterinary Sciences, University of Helsinki, Finland. reeta.poso@helsinki.fi
D000818:Animals; D001692:Biological Transport; D004734:Energy Metabolism / Q000502:physiology; D006736:Horses / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology*
D007773:Lactates; D027501:Monocarboxylic Acid Transporters