title: Relation of the G protein beta3-subunit polymorphism with left ventricle structure and function.
abstract: The G protein beta3-subunit C825T polymorphism results in a truncated splice variant protein that is associated with enhanced transmembrane signaling, increased proliferative activity, and arterial hypertension. The aim of the present study was to further investigate the association of this polymorphism with left ventricular (LV) structure and function. A total of 2052 individuals from a large-scale population-based sample were investigated for the G protein beta3-subunit C825T polymorphism and echocardiographic parameters of LV structure and function. Complete genotyping and echocardiographic data were available in 1720 individuals (829 men and 891 women). The mean LV mass indices in men with CC (n=384) and TT (n=84) genotypes were 98.3+/-1.2 g/m2 and 100.0+/-2.8 g/m2, respectively (P=0.64). In women, the corresponding values were 83.1+/-1.0 g/m2 for the CC genotype (n=397) and 83.8+/-2.1 g/m2 for the TT genotype (n=91, P=0.32). Likewise, LV dimensions or parameters of the diastolic function and serologic markers of LV mass were not associated with the C825T variant. Finally, multivariate analyses accounting for potentially confounding factors failed to show any influence of this polymorphism on echocardiographic parameters. In conclusion, we were not able to confirm the previously published associations of the G protein beta3-subunit C825T polymorphism with LV structure and diastolic function.
authors.affiliation: Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, Germany.
authors.forename: Kamil
authors.initials: K
authors.lastname: Sedlácek
authors.forename: Marcus
authors.initials: M
authors.lastname: Fischer
authors.forename: Jeanette
authors.initials: J
authors.lastname: Erdmann
authors.forename: Christian
authors.initials: C
authors.lastname: Hengstenberg
authors.forename: Stephan
authors.initials: S
authors.lastname: Holmer
authors.forename: Susanne
authors.initials: S
authors.lastname: Kürzinger
authors.forename: Michael
authors.initials: M
authors.lastname: Muscholl
authors.forename: Andreas
authors.initials: A
authors.lastname: Luchner
authors.forename: Günter A
authors.initials: GA
authors.lastname: Riegger
authors.forename: Hans-Werner
authors.initials: HW
authors.lastname: Hense
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
mesh_terms: D000367:Age Factors; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D004452:Echocardiography; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006352:Heart Ventricles / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012737:Sex Factors
chemical_list: D020962:Heterotrimeric GTP-Binding Proteins