title: Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients.
abstract: In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.
authors.affiliation: PHLS Antiviral Susceptibility Unit, Division of Immunity and Infection, University of Birmingham Medical School, Birmingham, UK.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Stéphane
authors.initials: S
authors.lastname: Hué
authors.forename: Stephen
authors.initials: S
authors.lastname: Taylor
authors.forename: Daina
authors.initials: D
authors.lastname: Ratcliffe
authors.forename: Judith A
authors.initials: JA
authors.lastname: Workman
authors.forename: Susan
authors.initials: S
authors.lastname: Jackson
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Cane
authors.forename: Deenan
authors.initials: D
authors.lastname: Pillay
mesh_terms: D019380:Anti-HIV Agents / Q000378:metabolism*; D001483:Base Sequence; D017931:DNA Primers; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000737:chemistry / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism*
chemical_list: D019380:Anti-HIV Agents; D017931:DNA Primers; D015700:HIV Envelope Protein gp41; D010446:Peptide Fragments; D000077560:Enfuvirtide