A delay in CD4 cell response after initiation of highly active antiretroviral therapy is associated with the presence of anti-cytomegalovirus but not with anti-herpes simplex virus antibodies.
After the successful initiation of highly active antiretroviral therapy (HAART) in HIV-1-infected patients, the mean CD4 cell response was lower in cytomegalovirus (CMV)-seropositive patients than in CMV-seronegative patients (P < 0.05). The difference between the mean CD4 cell counts of CMV-seronegative and CMV-seropositive patients was maximal (163 x 10(6)/l) at 76 weeks after the start of HAART, and decreased gradually thereafter. No association was found between herpes simplex virus types 1 and 2 serostatus and CD4 cell response.
Goossens
Valère J
VJ
Department of Medical Microbiology, University Hospital Maastricht, Maastricht, the Netherlands.
Schreij
Gerrit
G
van der Geest
Siebe
S
Van Leeuwen
Danitsja M
DM
Baas
Dominique C
DC
Bruggeman
Cathrien A
CA
van der Ven
André J
AJ
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003587:Cytomegalovirus / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D018139:Simplexvirus / Q000276:immunology*
D000914:Antibodies, Viral