title: [Effect of risk on the child of an older mother (case-control study)].
abstract: BACKGROUND
  During the last decades the number of births in women with 35 or more years of age has increased approximately 35-50%.
  
  
  OBJECTIVE
  To establish the neonatal morbidity associated with advanced maternal age, compared with mothers in the optimal reproductive stage.
  
  
  METHODS
  This is a retrospective case-control survey. In 1999 we revised 210 records from neonates and mothers with 35 or more years of age (cases) and 210 records of neonates and mothers with age between 18 and 34 years (controls). The variability significance was established with t-student, X2 and risk with the probabilistic risk ratio.
  
  
  RESULTS
  There was a significant difference in the socioeconomic and educational level. Advanced maternal age predisposed 2.43 times indication for cesarean section, increased the risk for gestational diabetes (11.35), toxemia (4.11) and in its severe form (2 times). Miscarriage menace (5.65 times). Lower birth weight (p < 0.007) and wet lung syndrome were more frequent in the advanced age group (p < 0.02). Risk for hypoglycemia was 1.62. There was also an increase in the risk for Trisomy 21 (p < 0.05) with an OR of 4 in cases. Genetic service evaluated 35 patients in the maternal advanced age group with an OR of 35.
  
  
  CONCLUSIONS
  Advance maternal age increases maternal morbidity and the risk for preterm delivery, low birth weight, asymptomatic hypoglycemia, wet lung syndrome and risk for chromosomopathies.
authors.forename: Silvia
authors.initials: S
authors.lastname: Romero-Maldonado
authors.forename: Claudia Angélica
authors.initials: CA
authors.lastname: Quezada-Salazar
authors.forename: Mario David
authors.initials: MD
authors.lastname: López Barrera
authors.forename: Leyla María
authors.initials: LM
authors.lastname: Arroyo Cabrales
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D025063:Chromosome Disorders / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D007234:Infant, Premature; D008297:Male; D008423:Maternal Age; D008800:Mexico / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018566:Pregnancy, High-Risk; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology; D012189:Retrospective Studies; D012306:Risk; D012959:Socioeconomic Factors