Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever.
In Iquitos, Peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by American genotype dengue-2 (American dengue-2) virus. We assayed serum samples collected in Iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two American dengue-2 viruses, and two Asian dengue-2 viruses. Sera positive for the dengue-1 antibody neutralised dengue-1 viruses and American dengue-2 viruses much more effectively than Asian dengue-2 viruses. Neutralisation of American dengue-2 virus by sera positive for dengue-1 antibodies may account for the absence of dengue haemorrhagic fever in individuals infected with dengue-1 in 1990-91 followed by American dengue-2 virus in 1995 in Iquitos, Peru.
Kochel
Tadeusz J
TJ
Department of Virology, Naval Medical Research Centre Detachment, Lima, Peru. Kochel@namrid.sld.pe
Watts
Douglas M
DM
Halstead
Scott B
SB
Hayes
Curtis G
CG
Espinoza
Angelica
A
Felices
Vidal
V
Caceda
Roxana
R
Bautista
Christian T
CT
Montoya
Ysabel
Y
Douglas
Susan
S
Russell
Kevin L
KL
D000914:Antibodies, Viral / Q000097:blood*; D003715:Dengue / Q000276:immunology; D003716:Dengue Virus / Q000145:classification* / Q000276:immunology; D006801:Humans; D010568:Peru; D016133:Polymerase Chain Reaction; D012703:Serotyping; D019595:Severe Dengue / Q000276:immunology
D000914:Antibodies, Viral