[Intraprostatic BCG vaccine in patients with prostatic cancer. Expression of interferon gamma and interleukin 4 (a preliminary study)].
The BCG treatment in the superficial bladder cancer is utilized since 1976. There are some animal experiences with BCG intraprostatic in dogs with prostatic cancer.


OBJECTIVE
determine if insitu BCG vaccine increase the prostatic immunity in patients with prostatic cancer.


METHODS
Three patients with D stage prostatic cancer where injected with 0.3-0.5 mg of BCG vaccine in the prostate. An histological picture where made in the some place before and after the injection. A RT-PCR study was made for gamma Interferon and Interleukin-4.


RESULTS
In two patients we observed gamma interferon expression (67%) respect the control, this produce an increase of the cytotoxic T lymphocytes, natural killer cells and macrophagos, that have antitumoral action. One patient increased the interleukin-4 that means production of T helper lymphocytes and B lymphocytes. There wasn't complications.


CONCLUSIONS
The BCG vaccine injected in prostatic tissue of patients with prostatic cancer, produces an increase of cytotoxic T lymphocytes and natural killer cells, with antitumoral action.
Rivera
P
P
Servicio de Urología, Hospital Regional Temuco, Unidad de Urología, Departamento de Especialidades, Departamento de Ciencias Básicas, Universidad de la Frontera de Temuco.
Inostroza
J
J
Treulén
F
F
D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D001706:Biopsy; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D001500:BCG Vaccine; D012333:RNA, Messenger; D015847:Interleukin-4; D007371:Interferon-gamma