Neuroradiologic screening in normal-pressure glaucoma: study results and literature review.
OBJECTIVE
To determine if there was an increased prevalence of intracranial compressive lesions in patients with clinically diagnosed normal-pressure glaucoma compared with a group of patients with progressive primary open-angle glaucoma.


METHODS
In a prospective, comparative, observational case series, the authors performed cranial magnetic resonance imaging in patients with consecutively diagnosed normal-pressure glaucoma (n = 62) and progressive primary open-angle glaucoma with controlled intraocular pressures (n = 70). The prevalence of intracranial compressive lesions, demographic data, and clinical characteristics were compared between both groups.


RESULTS
Four of the 62 (6.5%) patients with normal-pressure glaucoma had clinically relevant intracranial compressive lesions involving the anterior visual pathway, compared with none of the 70 patients with primary open-angle glaucoma (P = 0.039).


CONCLUSIONS
Intracranial compressive lesions are an important diagnostic consideration in the workup of normal-pressure glaucoma.
Ahmed
Iqbal Ike K
II
Department of Ophthalmology, University of Toronto, Toronto, Ontario, Canada.
Feldman
Fred
F
Kucharczyk
Walter
W
Trope
Graham E
GE
D000236:Adenoma / Q000150:complications / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016080:Arachnoid Cysts / Q000150:complications / Q000175:diagnosis; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D003943:Diagnostic Techniques, Neurological; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000175:diagnosis; D008579:Meningioma / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000175:diagnosis* / Q000209:etiology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis; D011446:Prospective Studies; D014794:Visual Fields; D014795:Visual Pathways / Q000473:pathology*