B cells and immunoglobulins dependent mechanisms in rheumatoid arthritis: a possible rationale of the extracorporeal immunomodulation for rheumatoid arthritis.
Patients with rheumatoid arthritis (RA) have several options for treatment nowadays, although we do not know what types of therapies are effective for these patients because RA is a very heterogenous disease. We discuss several possible mechanisms of RA in this review and explain one possible scenario of autoantibodies dependent arthritis confirmed by anti-glucose-6-phosphate isomerase antibodies. We also propose several efficacious treatments for treating these patients as made-to-order therapies.
Matsumoto
Isao
I
Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. ismatsu@md.tsukuba.ac.jp
Sumida
Takayuki
T
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000628:therapy; D001402:B-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D007136:Immunoglobulins / Q000276:immunology*; D051379:Mice
D007136:Immunoglobulins