Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats.
Alcoholic extract of Bacopa monniera was tested for its protective role on morphine-induced brain mitochondrial enzyme status in rats. The level of the brain mitochondrial enzymes was significantly lower in the morphine-treated group when compared with control animals. These enzymes were maintained at normal level when Bacopa extract was administered orally at a dose of 40 mg/kg, 2 h before the administration of morphine.
Sumathy
T
T
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, 600 025, Chennai, India.
Govindasamy
S
S
Balakrishna
K
K
Veluchamy
G
G
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D004347:Drug Interactions; D007194:India; D008297:Male; D008515:Medicine, Ayurvedic; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D009020:Morphine / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts; D020011:Protective Agents; D009020:Morphine