[Artemisinine and artesunate in the treatment of malaria in Vietnam (1984-1999)].
The long history of the use of Artemisia annua L. to treat malaria (called Quinghao in China and Thanh hao in Vietnam) has led Vietnamese scientists to manufacture locally preparations of artemisinine and artesunate, to test their tolerance for human beings as well as their efficiency in treating P. falciparum and P. vivax infections. Associating these drugs with antibiotics (such as tetracycline or doxycycline) could be an interesting topic for future research. Under the auspices of the National Program against Malaria, specialists will try to prevent the occurrence of drug resistance in Plasmodium and to propose new associations of drugs.
Phan
Vu Thi
VT
L'Institut national de malariologie, de parasitologie et d'entomologie Conseiller, programme national de lutte antipaludique 6 av. Ly Thuong-Kiet, Hanoï, Vietnam.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D037621:Artemisinins; D000077332:Artesunate; D002648:Child; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D004351:Drug Resistance; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000517:prevention & control; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000517:prevention & control; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use; D014744:Vietnam
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D000077332:Artesunate; C031327:artemisinin; D013752:Tetracycline; D004318:Doxycycline