title: Thiourea-based gemfibrozil analogues as HDL-elevating agents.
abstract: A series of gemfibrozil analogues with a thiourea moiety embedded in the side chain was prepared and evaluated as HDL-elevating agents. Derivatives 8b, 9b, 9c, and 9d were found to be approximately as effective as gemfibrozil (1) for HDL cholesterol elevation.
authors.affiliation: Department of Metabolic and Cardiovascular Diseases, Novartis Institute for Biomedical Research, Summit, NJ 07901, USA. gary.coppola@pharma.novartis.com
authors.forename: Gary M
authors.initials: GM
authors.lastname: Coppola
authors.forename: Robert E
authors.initials: RE
authors.lastname: Damon
authors.forename: J Bruce
authors.initials: JB
authors.lastname: Eskesen
authors.forename: Dennis S
authors.initials: DS
authors.lastname: France
authors.forename: James R
authors.initials: JR
authors.lastname: Paterniti
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood / Q000187:drug effects; D015248:Gemfibrozil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008075:Lipoproteins, HDL / Q000097:blood / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D016632:Apolipoprotein A-I; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D013890:Thiourea; D015248:Gemfibrozil