Identification of HLA-B*1566.
A novel polymorphism was identified in a B*15 allele. B*1566 possesses a nucleotide substitution of C to G at nucleotide 272. This polymorphism encodes an amino acid difference from serine in B*1501101 to cysteine in B*1566 at residue 67. Residue 67 is a constituent of the B pocket and is situated on the alpha1 helix facing into the groove. This mutation may have arisen through interallelic recombination as it has been seen in other B*15 alleles and is also present in most B*14, B*27, B*38, B*39 alleles and in B*7301.
Cox
S T
ST
The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom.
Prokupek
B
B
Baker
F
F
Holman
R
R
Leung
V T C
VT
Wong
A S W
AS
Madrigal
J A
JA
Little
A-M
AM
D019943:Amino Acid Substitution / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
D015235:HLA-B Antigens