Effect of NO synthase inhibitor L-NAME on DNA synthesis in the myocardium of albino rats during early postnatal ontogeny.
Effects of repeated treatment (5 times) with L-NAME, a NO synthase (eNOS) inhibitor on DNA synthesis in various zones of the heart in newborn albino rats was studied using 3H-thymidine autoradiography. This compound decreased (by 1.22-1.59 times) the count of labeled cardiomyocyte nuclei in various myocardial zones, particularly, in the myocardium of the left atrium, left ventricle, and interventricular septum. Changes in tissue proliferative activity were accompanied by activation of lipid peroxidation and inhibition of the antioxidant system in the myocardium.
Sazonova
E N
EN
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk. ElenaSazonova@lycos.ru
Pikalova
V M
VM
Timoshin
S S
SS
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006321:Heart / Q000033:anatomy & histology / Q000254:growth & development; D009206:Myocardium / Q000378:metabolism*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052250:Nitric Oxide Synthase Type III; D051381:Rats
D004791:Enzyme Inhibitors; D004247:DNA; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D019331:NG-Nitroarginine Methyl Ester