title: Mutagenic effects of carbosulfan, a carbamate pesticide.
abstract: The genotoxic effects of carbosulfan were evaluated using chromosome aberration (CA), bone marrow micronucleus (MN) and sperm abnormality assays in mice. All the three acute doses (1.25, 2.5 and 5mg/kg) of carbosulfan induced significant dose-dependent increase in the frequency of CA (P<0.02), micronucleated polychromatic erythrocytes (PCEs) (P<0.05) and sperm head abnormalities (P<0.05) but did not affect the total sperm count. The highest acute dose of carbosulfan induced >7-fold increase in the frequency of CA, >3.5-fold increase in the frequency of micronucleated PCEs and >4.6-fold increase in the frequency of sperms with abnormal head morphology following intraperitoneal exposure as compared to the untreated controls. The present findings suggest that carbosulfan is a potent genotoxic agent and may be regarded as a potential germ cell mutagen also.
authors.affiliation: Genetic Toxicology Laboratory, Department of Life Science, Assam University, P.O. Box 11, Silchar 788 011, India. girisarbani@yahoo.com
authors.forename: Sarbani
authors.initials: S
authors.lastname: Giri
authors.forename: Anirudha
authors.initials: A
authors.lastname: Giri
authors.forename: Gouri Dutt
authors.initials: GD
authors.lastname: Sharma
authors.forename: Surya Bali
authors.initials: SB
authors.lastname: Prasad
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D002219:Carbamates / Q000633:toxicity*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D013076:Sperm Count; D013077:Sperm Head / Q000187:drug effects
chemical_list: D002219:Carbamates; D009153:Mutagens; D010575:Pesticides; C035038:carbosulfan