title: Hematologic and serum biochemical changes in Salmonella ser Typhimurium-infected calves.
abstract: OBJECTIVE
  To evaluate hematologic and serum biochemical changes in Salmonella ser Typhimurium-infected calves.
  
  
  METHODS
  16 male 3- to 4-week-old dairy calves.
  
  
  METHODS
  13 calves were experimentally infected with S Typhimurium (strains IR715 and CS401, which are derivatives of ATCC 14028), and 3 calves were uninfected controls. Several hematologic and serum biochemical parameters were measured.
  
  
  RESULTS
  Hematologic changes included increases in PCV, RBC count, and hemoglobin concentration, associated with a transitory leukopenia characterized by neutropenia and lymphopenia. Biochemical findings included hypoglycemia, increased BUN, creatinine, and fibrinogen concentrations, and decreased sodium, total CO2, calcium, total protein, and albumin concentrations. Increased total bilirubin concentration associated with decreased conjugated bilirubin concentration was also observed. No significant changes in aspartate aminotransferase, gamma-glutamyltranspeptidase, alkaline phosphatase, and creatinine kinase activities were detected.
  
  
  CONCLUSIONS
  Experimental salmonellosis of calves results in marked to severe dehydration, accompanied by metabolic acidosis, hypoglycemia, and an acute inflammatory response associated with increased fibrinogen concentrations and severe neutropenia immediately after inoculation.
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station 77843-4467, USA.
authors.forename: Renato L
authors.initials: RL
authors.lastname: Santos
authors.forename: Renée M
authors.initials: RM
authors.lastname: Tsolis
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Bäumler
authors.forename: L Garry
authors.initials: LG
authors.lastname: Adams
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001774:Blood Chemical Analysis / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000201:enzymology / Q000382:microbiology*; D003402:Creatine Kinase / Q000097:blood; D004906:Erythrocyte Count / Q000662:veterinary; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D018655:Lymphocyte Count; D008297:Male; D012481:Salmonella Infections, Animal / Q000097:blood* / Q000201:enzymology / Q000382:microbiology*; D012486:Salmonella typhimurium; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D006454:Hemoglobins; D005340:Fibrinogen; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D000469:Alkaline Phosphatase