title: Synthesis and cytotoxicity of the dihydrated complex of oxaliplatin.
abstract: A new way of synthesizing the dihydrated oxaliplatin complex (DOC) is presented and its cytotoxicity is compared to that of oxaliplatin and cisplatin. By hydrolyzing oxaliplatin in aqueous sodium hydroxide at 70 degrees C, DOC was formed in less than 1 h. Cytotoxicity was studied in the non-small cell lung cancer cell line A549 using the fluorescent microculture cytotoxic assay. Oxaliplatin and cisplatin had similar cytotoxicity profiles, whereas DOC was found to be considerably more toxic. The cytotoxicity of oxaliplatin might, at least in part, be mediated through the formation of DOC.
authors.affiliation: Karolinska Pharmacy, Karolinska Hospital, SE-171 76 Stockholm, Sweden.
authors.forename: Pernilla
authors.initials: P
authors.lastname: Videhult
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Yachnin
authors.forename: Elin
authors.initials: E
authors.lastname: Jerremalm
authors.forename: Rolf
authors.initials: R
authors.lastname: Lewensohn
authors.forename: Hans
authors.initials: H
authors.lastname: Ehrsson
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009944:Organoplatinum Compounds / Q000494:pharmacology; D000077150:Oxaliplatin; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin