[Mathematical model of trans-sarcomere exchange of calcium ions and Ca2+-dependent control of smooth muscle contractile activity].
The mathematical model of smooth muscles contractile activity Ca(2+)-dependent control has been proposed on the base of Ca ions trans-sarcomal exchange biochemical mechanisms interpretation in myocytes. While analysing the model the conclusion should be made that kinetic parameters changes (in relation to Ca ions) Mg2+, ATP-dependent calcium pump of plasma membrane--Michaelis constant Km and transport process maximal velocity Vmax-render the effect on the character of the intracellular calcium transients and profile of full mechanokinetic curve. As well one more conclusion has been made that plasma membrane Mg2+, ATP-dependent calcium pump, which kinetic parameters under the physiologic conditions are subjected to modulation as the result of metabolic, pharmacologic and physico-chemical factors fulfills the essential role in supplying Ca(2+)-dependent control of the smooth muscles contractile response full cycle.
Kosterin
S O
SO
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Miroshnychenko
M S
MS
Pryluts'kyĭ
Iu I
IuI
Davydovs'ka
T L
TL
Tsymbaliuk
O V
OV
D000255:Adenosine Triphosphate / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D009130:Muscle, Smooth / Q000378:metabolism*; D012518:Sarcomeres / Q000378:metabolism*
D000255:Adenosine Triphosphate; D002118:Calcium