title: Cerebral cortex lesions decrease the number of bromodeoxyuridine-positive subventricular zone cells in mice.
abstract: We previously showed that cortical lesions in rats increase the number of subventricular zone (SVZ) cells. Here, we examined the response of the SVZ to cortical lesions in mice from 6 h to 35 days later. Whereas the total number of cells did not change, the number of cells in S-phase (bromodeoxyuridine-positive) decreased in a biphasic manner (from 6 h to day 3, and again at days 25-35). In addition, there was a delayed (days 25-35) increase in immunoreactivity for polysialylated neural cell adhesion molecule, a marker of neuroblasts. The results suggest that in mice there are rapid as well as delayed responses in the SVZ to injury of the overlying cerebral cortex. They also show that the SVZ of different mammalian species can exhibit widely divergent responses to the same brain injury.
authors.affiliation: CMIER Neurobiology Program, Children's Memorial Hospital, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 2430 N. Halsted, No. 209, Chicago, IL 60614-3394, USA.
authors.forename: Gwendolyn E
authors.initials: GE
authors.lastname: Goings
authors.forename: Bernadeta L
authors.initials: BL
authors.lastname: Wibisono
authors.forename: Francis G
authors.initials: FG
authors.lastname: Szele
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism / Q000473:pathology; D001973:Bromodeoxyuridine / Q000378:metabolism*; D002452:Cell Count / Q000379:methods / Q000706:statistics & numerical data; D002455:Cell Division / Q000502:physiology; D002540:Cerebral Cortex / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology*; D002552:Cerebral Ventricles / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D013997:Time Factors
chemical_list: D001973:Bromodeoxyuridine