Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia.
Tranexamic acid (an antifibrinolytic agent) is of proven benefit in the treatment of bleeding in patients with congenital and acquired coagulation disorders. We report the case of a patient with an acquired Factor VIII inhibitor, who was on a prophylactic dose of tranexamic acid because of recurrent bleeding episodes and developed a pulmonary embolism. Although studies using tranexamic acid have not shown a definite increased risk for the development of venous thrombosis, this is the likely cause of the pulmonary embolism in this patient.
Taparia
Minakshi
M
Department of Hematology, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia.
Cordingley
Frank T
FT
Leahy
Michael F
MF
D000328:Adult; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D005169:Factor VIII / Q000276:immunology; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006470:Hemorrhage / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000139:chemically induced*; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000009:adverse effects*
D000933:Antifibrinolytic Agents; D001323:Autoantibodies; D014148:Tranexamic Acid; D005169:Factor VIII