Differential pulse adsorption voltammetry for determination of procaine hydrochloride at a pumice modified carbon paste electrode in pharmaceutical preparations and urine.
Procaine hydrochloride was determined by the differential pulse voltammetry (DPV) using a 6% (m/m) pumice modified carbon paste electrode in 1.25 x 10(-3) mol x l(-1) KH(2)PO(4) and Na(2)HPO(4) buffer solution (pH 6.88, 25 degrees C). The anodic peak potential used was +0.980 V (vs. SCE). A good linear relationship was realized between the anodic peak current and procaine concentration in the range of 9.0 x 10(-7)-2.6 x 10(-5) mol x l(-1) with the detection limit of 5.0 x 10(-8) mol x l(-1). The recovery was 95.2-104.8% with the relative standard deviation of 3.2% (n=10). The pharmaceutical preparations, procaine hydrochloride injection and the urine samples were determined with the desirable results.
Wang
Cheng Yin
CY
Department of Chemistry and Chemical Engineering, Yangzhou University, 225002, Yangzhou, People's Republic of China.
Hu
Xiao Ya
XY
Jin
Gen Di
GD
Leng
Zong Zhou
ZZ
D000779:Anesthetics, Local / Q000032:analysis* / Q000652:urine; D002138:Calibration; D002244:Carbon; D004563:Electrochemistry; D004566:Electrodes; D006801:Humans; D007202:Indicators and Reagents; D011343:Procaine / Q000032:analysis* / Q000652:urine; D015203:Reproducibility of Results; D017640:Silicates / Q000737:chemistry*
D000779:Anesthetics, Local; D007202:Indicators and Reagents; D017640:Silicates; D011343:Procaine; D002244:Carbon; C005144:pumice