title: LINE drive. retrotransposition and genome instability.
abstract: The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.
authors.affiliation: Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA. kazazian@mail.med.upenn.edu
authors.forename: Haig H
authors.initials: HH
authors.lastname: Kazazian
authors.forename: John L
authors.initials: JL
authors.lastname: Goodier
mesh_terms: D000818:Animals; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D019143:Evolution, Molecular; D017353:Gene Deletion; D015894:Genome, Human; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D020084:Long Interspersed Nucleotide Elements / Q000235:genetics*; D051379:Mice; D016297:Mutagenesis, Site-Directed / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*
chemical_list: D036022:Capsid Proteins; D006023:Glycoproteins; D018626:Retroelements