title: Cystic metastasis versus branchial cleft carcinoma: a diagnostic challenge.
abstract: OBJECTIVE
  There is controversy regarding the existence of branchial cleft carcinomas. The objectives are to familiarize the clinician with the presentation and treatment of cystic metastases from head and neck primary sites and differentiate these from primary branchial cleft cyst carcinomas.
  
  
  METHODS
  Retrospective case study and literature review.
  
  
  METHODS
  Published reports of branchial cleft carcinomas were reviewed in conjunction with a unique case presenting at the University of Texas Medical Branch (Galveston, TX).
  
  
  RESULTS
  Most cases of branchial cleft carcinomas are probably cystic metastases from head and neck primary sites. Cutaneous involvement with primary branchial cleft carcinomas is rare but may occur in recurrent lesions.
  
  
  CONCLUSIONS
  The diagnosis of a primary branchial cleft cyst carcinoma requires the fulfillment of strict criteria. Cystic metastases from head and neck primaries can mimic branchial cleft carcinomas histologically. Correct diagnosis is important so that appropriate surgical and radiotherapeutic treatment can be delivered.
authors.affiliation: Department of Otolaryngology, University of Texas Medical Branch, Galveston 77555-0521, USA.
authors.forename: Russell D
authors.initials: RD
authors.lastname: Briggs
authors.forename: Anna M
authors.initials: AM
authors.lastname: Pou
authors.forename: Vicki J
authors.initials: VJ
authors.lastname: Schnadig
mesh_terms: D001935:Branchioma / Q000473:pathology*; D003937:Diagnosis, Differential; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies