title: Field trials in Norway with SLICE (0.2% emamectin benzoate) for the oral treatment of sea lice infestation in farmed Atlantic salmon Salmo salar.
abstract: Four commercial salmon farms on the West coast of Norway were recruited to a programme of field trials in which the efficacy of SLICE (0.2% emamectin benzoate; Schering-Plough Animal Health) was compared with a commercially available product, EKTOBANN (teflubenzuron 2 g kg(-1); Skretting A/S) in treating natural sea lice Lepeophtheirus salmonis infections in Atlantic salmon Salmo salmar L. At each test site, 3 fish pens were treated with each product. In total, nearly 1.2 million first-year-class fish were included in the trial, of which approximately 561,000 received emamectin benzoate at a dosage of 50 microg kg(-1) body wt d(-1), while approximately 610,000 received teflubenzuron at a dosage of 10 mg kg(-1) body wt d(-1). Medicated feed was provided at 0.5% body wt d(-1) over 7 consecutive days. Feed containing emamectin benzoate was generally well accepted by the fish and no problems were encountered in feeding the medicated diet at the desired dose. Lice numbers were counted 2 d before and 1, 7, 14 and 21 d after commencement of treatment. While treatment with both substances rapidly reduced lice numbers, pens treated with emamectin benzoate were found to harbour significantly fewer lice 14 and 21 d post-treatment. Twenty-one days following treatment with emamectin benzoate the lice abundance was reduced on average by 94%. Limited sampling outside the main study period indicated that emamectin benzoate protects against sea-lice infestation over longer periods.
authors.affiliation: VESO Vikan AkvaVet, Namsos, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Ramstad
authors.forename: D J
authors.initials: DJ
authors.lastname: Colquhoun
authors.forename: R
authors.initials: R
authors.lastname: Nordmo
authors.forename: I H
authors.initials: IH
authors.lastname: Sutherland
authors.forename: R
authors.initials: R
authors.lastname: Simmons
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017756:Aquaculture; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use; D003445:Crustacea; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary*; D005393:Fish Diseases / Q000188:drug therapy*; D007306:Insecticides / Q000008:administration & dosage* / Q000627:therapeutic use; D007559:Ivermectin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009664:Norway; D020317:Salmo salar / Q000469:parasitology*; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D007306:Insecticides; D007559:Ivermectin; C052595:teflubenzuron; C108024:emamectin benzoate