title: Pulmonary iron overload in thalassemia major presenting as small airway disease.
abstract: Lung function abnormalities that are associated with thalassemia major are variable with etiology that is yet undetermined. Some studies have suggested that pulmonary iron deposition is a probable cause for these lung defects although there has been no antemortem histopathological and radiological evidence for this. We report a case of thalassemia major with biopsy-proven pulmonary iron overload, in which thoracic high-resolution computed tomography revealed a morphological-functional correlation consistent with small airway disease.
authors.affiliation: Department of Diagnostic Radiology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China. cgcooi@hkucc.hku.hk
authors.forename: G C
authors.initials: GC
authors.lastname: Ooi
authors.forename: P L
authors.initials: PL
authors.lastname: Khong
authors.forename: W K
authors.initials: WK
authors.lastname: Lam
authors.forename: N J
authors.initials: NJ
authors.lastname: Trendell-Smith
authors.forename: K W T
authors.initials: KW
authors.lastname: Tsang
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000209:etiology*; D001706:Biopsy; D015913:Chelation Therapy; D003131:Combined Modality Therapy; D003676:Deferoxamine / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D007328:Insulin / Q000627:therapeutic use; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D007674:Kidney Diseases / Q000150:complications; D008171:Lung Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D008264:Macrophages / Q000737:chemistry / Q000473:pathology; D010349:Patient Compliance; D013156:Splenectomy; D014057:Tomography, X-Ray Computed; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000150:complications* / Q000601:surgery / Q000628:therapy
chemical_list: D007328:Insulin; D007502:Iron Chelating Agents; D006485:Hemosiderin; D003676:Deferoxamine