title: An active intervention on flap vasculature: flap prefabrication by pedicle implantation, delay, pre-expansion, pre-grafting, tissue engineering, biomaterials and perforators surgery.
abstract: The technology of flap prefabrications is a new, powerful tool in plastic and reconstructive surgery. It is based on an old idea, while applying the latest innovations in surgery. It involves any modification of a surgical flap done before its transfer to the final donor site, including surgical delay, pre-expansion, pre-grafting, the use of tissue engineering, biomaterials and perforators surgery, or the creation of a new pedicle by staged transfer of a vascular bundle. The different possibilities are discussed, with special reference to their biologic basis.
authors.affiliation: Divisione di Chirurgia Plastica Ricostruttiva, Università di Messina.
authors.forename: M R
authors.initials: MR
authors.lastname: Colonna
authors.forename: L
authors.initials: L
authors.lastname: Teot
authors.forename: U M
authors.initials: UM
authors.lastname: Giovannini
authors.forename: F
authors.initials: F
authors.lastname: Quatra
authors.forename: F Stagno
authors.initials: FS
authors.lastname: d'Alcontres
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D016207:Cytokines / Q000502:physiology; D006801:Humans; D008866:Microsurgery; D051381:Rats; D012106:Research; D013524:Surgical Flaps / Q000098:blood supply; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D016207:Cytokines