Age-structured formulation of cellular proliferation.
Articles concerning mathematical formulation of proliferating cells in well-mixed batch culture are reviewed. An age-structured formulation which takes varying generation times into consideration is shown to be able to explain the partial synchronization observed when the cells in the batch culture are starved. With this formulation, significance of the logarithmic phase is reconsidered. Further, the formulation is applied to describe age-structured population dynamics in fed-drained culture.
Funakoshi
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Department of Chemistry, The College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Japan.
D002452:Cell Count; D002455:Cell Division; D002478:Cells, Cultured; D016922:Cellular Senescence; D008433:Mathematics; D008954:Models, Biological