title: Chronic diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome associated with HEp-2 adherent Escherichia coli in adults infected with human immunodeficiency virus in Bangui, Central African Republic.
abstract: In human immunodeficiency virus (HIV)-infected adults from the Central African Republic, the occurrence of chronic diarrhea due to HEp-2 adherent Escherichia coli (EAEC) harboring virulence markers (eaeA, BFP, EAF, astA determinant of EAST/1, positive FAS test, enteropathogenic E. coli O serogroup) was shown to be associated with AIDS. We also show that EAEC that produce verotoxin (Stx2) but do not harbor the genetic markers for classical enterohemorrhagic E. coli are involved in hemorrhagic colitis and hemolytic-uremic syndrome in patients with HIV.
authors.affiliation: Unité des Maladies Infectieuses Opportunistes, Institut Pasteur de Bangui, Central African Republic.
authors.forename: Christian
authors.initials: C
authors.lastname: Mossoro
authors.forename: Philippe
authors.initials: P
authors.lastname: Glaziou
authors.forename: Simon
authors.initials: S
authors.lastname: Yassibanda
authors.forename: Nguyen Thi Phuong
authors.initials: NT
authors.lastname: Lan
authors.forename: Claudine
authors.initials: C
authors.lastname: Bekondi
authors.forename: Pierre
authors.initials: P
authors.lastname: Minssart
authors.forename: Christine
authors.initials: C
authors.lastname: Bernier
authors.forename: Chantal
authors.initials: C
authors.lastname: Le Bouguénec
authors.forename: Yves
authors.initials: Y
authors.lastname: Germani
mesh_terms: D000328:Adult; D001422:Bacterial Adhesion; D002460:Cell Line; D002488:Central African Republic; D002908:Chronic Disease; D003092:Colitis / Q000382:microbiology*; D003967:Diarrhea / Q000382:microbiology*; D004926:Escherichia coli / Q000472:pathogenicity* / Q000502:physiology; D004927:Escherichia coli Infections / Q000382:microbiology; D006471:Gastrointestinal Hemorrhage / Q000382:microbiology; D015658:HIV Infections / Q000150:complications*; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology*; D006801:Humans