Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil.
The effects of the central-type benzodiazepine receptor antagonist flumazenil on renal vascular tone and its ability to reverse the benzodiazepine-induced vasodilation were investigated. The isolated and perfused rat kidney model was used. Flumazenil was unable to modify renal vascular resistance under basal conditions and in noradrenaline-pretreated kidneys. Relaxation induced by diazepam or clonazepam of noradrenaline-preconstricted renal vasculature was blunted by 10 microM flumazenil. These results suggest that central-type benzodiazepine receptors could be involved in benzodiazepine-induced renal vasodilation.
Monasterolo
Liliana A
LA
Farmacología, Facultad de Ciencias Bioqui;micas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina. l_monasterolo@yahoo.com
Trumper
Laura
L
Elías
M Mónica
MM
D000818:Animals; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005442:Flumazenil / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology*; D008297:Male; D009125:Muscle Relaxants, Central / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D018757:GABA Modulators; D009125:Muscle Relaxants, Central; D014662:Vasoconstrictor Agents; D005442:Flumazenil; D002998:Clonazepam; D003975:Diazepam; D009638:Norepinephrine