Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults.
An open-label, multicenter study was performed to assess bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults. Seventy aerobic (52.2%) and 64 anaerobic (47.8%) pathogens were recovered from clinically evaluable patients at baseline (before therapy). The most commonly isolated anaerobes were Prevotella species (31.1%), anaerobic streptococci (21.9%), and Fusobacterium species (15.6%). The aerobes most frequently recovered included Streptococcus species (21.4%), Haemophilus influenzae (15.7%), Pseudomonas aeruginosa (15.7%), and Staphylococcus aureus and Moraxella catarrhalis (10.0% each). Recurrences of signs or symptoms of bacterial maxillary sinusitis associated with anaerobes were twice as frequent as were those associated with aerobes when counts of anaerobes were > or =10(3) cfu/mL. A pathogenic role for Granulicatella species in cases of chronic sinusitis was documented for the first time.
Finegold
S M
SM
Veterans Affairs Medical Center West Los Angeles, and University of California, Los Angeles, School of Medicine, CA 90073, USA. sidfinegol@aol.com
Flynn
M J
MJ
Rose
F V
FV
Jousimies-Somer
H
H
Jakielaszek
C
C
McTeague
M
M
Wexler
H M
HM
Berkowitz
E
E
Wynne
B
B
D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D001420:Bacteria, Aerobic / Q000187:drug effects; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D015523:Maxillary Sinusitis / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology
D004791:Enzyme Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination; D010400:Penicillin G