Chronic obstructive pulmonary disease. 1: Susceptibility factors for COPD the genotype-environment interaction.
Genetic factors including alpha(1)-antitrypsin deficiency are important in COPD. Candidate gene association studies in COPD are reviewed. Efforts to identify interactions between genetic factors and environmental determinants such as smoking may lead to improved understanding of the pathogenesis of the disease.
Sandford
A J
AJ
University of British Columbia McDonald Research Laboratories/iCAPTURE Center, St Paul's Hospital, Vancouver, BC, Canada. asandford@mrl.ubc.ca
Silverman
E K
EK
D000975:Antioxidants / Q000378:metabolism; D010450:Endopeptidases / Q000235:genetics; D005541:Forced Expiratory Volume / Q000502:physiology; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D012907:Smoking / Q000235:genetics; D014797:Vital Capacity / Q000502:physiology; D019896:alpha 1-Antitrypsin Deficiency / Q000235:genetics
D000975:Antioxidants; D005982:Glutathione Transferase; D010450:Endopeptidases