title: p53 mutations and microsatellite instabilities in the subtype of intestinal metaplasia of the stomach.
abstract: To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI) both in the complete type (type I) and in the sulphomucin-secreting incomplete type (type III) intestinal metaplasia located adjacent to the gastric carcinoma. p53 mutations were observed in 13.3% of type I, in 6.6% of type III intestinal metaplasia, and in 40% of gastric carcinoma. The difference between p53 mutations observed in type I and type III intestinal metaplasia was not statistically significant. No identical mutation of the p53 gene was found in the intestinal metaplasia and carcinoma specimens from the patients. There was no case of intestinal metaplasia showing MSI. In gastric carcinomas, MSI was observed in six cases (40%). The cases harboring BAT-26 instability did not have the mutation of the p53 gene. These data suggest that intestinal metaplasia adjacent to gastric carcinoma, irrespective of its subtype, do not have the genetic alterations as showing in their carcinoma tissues.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Choon Sang
authors.initials: CS
authors.lastname: Bhang
authors.forename: Ki Ouk
authors.initials: KO
authors.lastname: Min
authors.forename: Hiun Suk
authors.initials: HS
authors.lastname: Chae
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Choi
authors.forename: Chang Don
authors.initials: CD
authors.lastname: Lee
authors.forename: Keun Woo
authors.initials: KW
authors.lastname: Lim
authors.forename: In Sik
authors.initials: IS
authors.lastname: Chung
authors.forename: Doo Ho
authors.initials: DH
authors.lastname: Park
mesh_terms: D002277:Carcinoma / Q000235:genetics / Q000473:pathology; D005091:Exons; D016158:Genes, p53; D006801:Humans; D008679:Metaplasia / Q000235:genetics / Q000473:pathology; D018895:Microsatellite Repeats; D009154:Mutation; D011230:Precancerous Conditions; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53