Stem cell plasticity?
Cells differentiate according to stereotype pedigrees, or at least so we thought. Several studies have challenged this dogma and suggested that stem cells in several tissues may be plastic and switch lineages, but many of the results are open to other interpretations. Is there solid evidence for stem cell plasticity and should we rewrite the textbooks just yet?
Frisén
Jonas
J
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden. jonas.frisen@cmb.ki.se
D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism* / Q000648:ultrastructure; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D023421:Models, Animal; D009473:Neuronal Plasticity / Q000502:physiology*; D010641:Phenotype; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
D015415:Biomarkers