title: Enantioselective synthesis of no-carrier-added (NCA) 6-[18F]fluoro-L-DOPA.
abstract: The application of a chiral phase-transfer-catalyst (PTC) in the synthesis of N.C.A. 6-[18F]fluoro-L-DOPA has been recently developed. The 6-trimethylammoniumveratraldehyde triflate precursor and PTC (O-allyl-N-(9)-anthracenylcinchonidinium bromide) were synthesized and successful synthesis route was developed for the preparation of 6-[18F]fluoro-L-DOPA with high radiochemical yields (4-9%, decay uncorrected) and short synthesis time (80min). The radiochemical purity was over 99% and no D-isomer was detected by HPLC analysis using a chiral mobile phase.
authors.affiliation: Shanghai Institute of Nuclear Research, Chinese Academy of Sciences. zhangl@sina.com
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Ganhua
authors.initials: G
authors.lastname: Tang
authors.forename: Duanzhi
authors.initials: D
authors.lastname: Yin
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Tang
authors.forename: Yonxian
authors.initials: Y
authors.lastname: Wang