title: Neuropathologic findings in a Guillain-Barré patient with strokes after IVIg therapy.
abstract: Strokes have been rarely associated with immunoglobulin G (IVIg) therapy. A 70-year-old woman with stable polycythemia vera developed Guillain-Barré syndrome and received IVIg, 8 days following which she became comatose due to bilaterally symmetric cerebral infarcts. Autopsy showed intravascular aggregates of fibrin-IgG but also platelets and a necrotizing microangiopathy in the infarcts.
authors.affiliation: Department of Pathology and Laboratory Medicine (Neuropathology), School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
authors.forename: N P
authors.initials: NP
authors.lastname: Byrne
authors.forename: J C
authors.initials: JC
authors.lastname: Henry
authors.forename: D N
authors.initials: DN
authors.lastname: Herrmann
authors.forename: A N
authors.initials: AN
authors.lastname: Abdelhalim
authors.forename: D A
authors.initials: DA
authors.lastname: Shrier
authors.forename: C W
authors.initials: CW
authors.lastname: Francis
authors.forename: J M
authors.initials: JM
authors.lastname: Powers
mesh_terms: D000368:Aged; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use*; D020521:Stroke / Q000209:etiology* / Q000473:pathology*
chemical_list: D016756:Immunoglobulins, Intravenous