title: Frontotemporal dementia.
abstract: Frontotemporal dementia is a new name for clinical Pick's disease; the eponymic term PiD has been increasingly restricted to the pathologic variant with Pick bodies. This article describes the clinical picture, pathology, and genetic mechanisms of frontal lobe dementia. Frontotemporal dementia is still under-diagnosed and underestimated, partly because the individual components of the complex are considered separately or are considered "heterogeneous," a somewhat misleading adjective used in many descriptions. This article emphasizes the considerable overlap among the different varieties of frontotemporal dementia, as well as the distinctive features of each.
authors.affiliation: Department of Clinical Neurological Sciences, St. Joseph's Hospital, University of Western Ontario, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada. andrew.kertesz@sjhc.london.on.ca
authors.forename: Andrew
authors.initials: A
authors.lastname: Kertesz
authors.forename: David G
authors.initials: DG
authors.lastname: Munoz
mesh_terms: D018888:Aphasia, Primary Progressive / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D020774:Pick Disease of the Brain / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D016875:tau Proteins / Q000302:isolation & purification
chemical_list: D016875:tau Proteins