title: The structure-activity relationship of flavonoids as scavengers of peroxynitrite.
abstract: Peroxynitrite is a cytotoxic intermediate produced by the reaction between a superoxide anion radical and nitric oxide. The scavenging activities of flavonoids on peroxynitrite were investigated to illustrate the structure-activity relationship. Peroxynitrite was scavenged by the presence of various flavonoids, whose structures seem to be closely related to the degree of scavenging. Of 31 compounds tested, the most active was quercetin, with an IC50 value of 0.93 microM. Others had IC50 values ranging from 0.96 to more than 10 microM. The scavenging activity was postulated to be governed by the position of the hydroxyl group. Ortho-hydroxyl structures increased the scavenging activity on peroxynitrite.
authors.affiliation: Faculty of Food Science and Biotechnology, Pukyong National University, Pusan, Korea. choijs@pknu.ac.kr
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Mee Jung
authors.initials: MJ
authors.lastname: Jung
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: No
authors.forename: Hyun Ah
authors.initials: HA
authors.lastname: Jung
mesh_terms: D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D044948:Flavonols; D016166:Free Radical Scavengers / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D010396:Penicillamine / Q000494:pharmacology; D030421:Peroxynitrous Acid / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology
chemical_list: D044950:Flavanones; D005419:Flavonoids; D044948:Flavonols; D016166:Free Radical Scavengers; D030421:Peroxynitrous Acid; D011794:Quercetin; D010396:Penicillamine; C028610:flavanone