Sirolimus lowers myeloperoxidase and p-ANCA titers in a pediatric patient before kidney transplantation.
We report the case of a child with microscopic polyangiitis (myeloperoxidase-antineutrophil cytoplasmic antibody [p-ANCA]-positive vasculitis) whose disease progressed to end-stage renal failure, in whom sirolimus contributed to normalization of myeloperoxidase and ANCA titers. The disease course, various therapies, and outcome are discussed, as is the rationale for using sirolimus.
Constantinescu
Alex R
AR
Department of Pediatric Nephrology and Transplant Surgery, University of Medicine and Dentistry of New Jersey-Robert Wood Jonson Medical School, New Brunswick, NJ 08903, USA. constaar@umdnj.edu
Liang
Michael
M
Laskow
David A
DA
D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000097:blood / Q000276:immunology*; D020123:Sirolimus / Q000494:pharmacology / Q000627:therapeutic use*; D019172:Transplantation Conditioning / Q000379:methods*; D014657:Vasculitis / Q000150:complications
D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D009195:Peroxidase; D020123:Sirolimus