title: A convenient method for the synthesis of C-protected esters of BOC-/Z-alpha,alpha- dialkylamino acids by the mixed carboxylic carbonic anhydride method.
abstract: The synthesis of C-protected esters of Boc-/Z-alpha,alpha-dialkylamino acids is accomplished by using alkyl/aryl chloroformate in presence of DMAP as a catalyst. The reaction proceeds through mixed carboxylic carbonic anhydride, which was monitored by IR. The reaction was clean and complete in about 2 hr. All the esters prepared have been obtained in good yield and are fully characterized.
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, 560 001, India. hariccb@rediffmail.com
authors.forename: Vommina V Suresh
authors.initials: VV
authors.lastname: Babu
authors.forename: Kuppanna
authors.initials: K
authors.lastname: Ananda
authors.forename: Ganga-Ramu
authors.initials: GR
authors.lastname: Vasanthakumar
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D005563:Formic Acid Esters / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000596:Amino Acids; D000812:Anhydrides; D002264:Carboxylic Acids; D005563:Formic Acid Esters; C000345:t-butyloxycarbonyl group