title: Pristane (2,6,10,14-Tetramethyl-pentadecane) inhibits disease progression in Leishmania-infected Balb/c mice.
abstract: The course of Leishmania infection in pristane-primed BALB/c mice infected with either Leishmania major or Leishmania donovani was examined. Pristane-primed L. donovani infected mice had spleen parasite-loads that were 13 times less than controls. Likewise pristane-primed L. major infected animals had significantly smaller footpad lesion areas than controls. Pristane-primed mice had an atypical haematology compared to controls. To the best of our knowledge, this is the first report to demonstrate that pristane inhibits progression of disease in Leishmania-infected BALB/c mice.
authors.affiliation: Biomedical Sciences Research Centre, Kenya Medical Research Institute, P.O.Box 54840, Nairobi, Kenya.
authors.forename: Peter A.
authors.initials: PA
authors.lastname: Mbati
authors.forename: Kisia
authors.initials: K
authors.lastname: Abok
authors.forename: Alloys S.
authors.initials: AS
authors.lastname: Orago
authors.forename: Christopher O.
authors.initials: CO
authors.lastname: Anjili
authors.forename: Jim M.
authors.initials: JM
authors.lastname: Kagai
authors.forename: John I.
authors.initials: JI
authors.lastname: Githure
authors.forename: Davy K.
authors.initials: DK
authors.lastname: Koech