Use of plasma clearance of technetium Tc 99m pentetate to estimate renal clearance during postnatal development in pigs.
OBJECTIVE
To compare renal clearance of technetium Tc 99m pentetate with plasma clearance by use of a glomerular filtration rate technique in pigs from 3 to 24 weeks of age.


METHODS
24 female pigs.


METHODS
At the time of investigation, 5 pigs were 3 weeks old, 6 pigs were 6 weeks old, 8 pigs were 12 weeks old, and 5 pigs were 24 weeks old. Plasma clearance of technetium Tc 99m pentetate was measured by the use of a single injection technique followed by collection of multiple blood samples until 5 hours after the injection. Simultaneously, urine was collected through a urinary catheter, and the renal clearance of technetiumTc 99m pentetate was calculated. Plasma clearance of technetium Tc 99m pentetate was correlated with the renal clearance (r = 0.95). Plasma clearance was higher than renal clearance at all ages (mean, 5.8%), indicating extrarenal clearance of technetium Tc 99m pentetate or methodologic errors. Volume of distribution increased with increasing age but decreased as a fraction of body weight.


CONCLUSIONS
Plasma clearance of technetium Tc 99m pentetate estimates renal clearance with acceptable precision when using single injection technique and multiple biood samples in pigs from 3 to 24 weeks of age.
Eskild-Jensen
Anni
A
Institute of Experimental Clinical Research, University of Aarhus, Denmark.
Rehling
Michael
M
Nielsen
Asker S
AS
Nielsen
Lene E
LE
Frøkiaer
Jørgen
J
D000818:Animals; D001835:Body Weight / Q000502:physiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary; D007668:Kidney / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D013552:Swine / Q000378:metabolism*; D016284:Technetium Tc 99m Pentetate / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate