title: Preconditioning hypobaric hypoxia prevents anoxia-induced inhibition of generation of focal potentials in slices of olfactory cortex from rat brain.
abstract: We studied the effect of in vivo exposure to hypobaric hypoxia of different depth on the resistance of neurons in brain slices to 10-min anoxia in vitro. Severe hypoxia simulating ascent to 11,000 m above sea level potentiated the adverse effect of 10-min anoxia and caused profound suppression of synaptic transmission. Moderate preconditioning hypoxia simulating ascent to 5000 m above sea level produced a long-lasting protective effect on synaptic activity.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. anoxia@pavlov.infran.ru
authors.forename: D Y
authors.initials: DY
authors.lastname: Romanovskii
authors.forename: E I
authors.initials: EI
authors.lastname: Tyul'kova
authors.forename: M O
authors.initials: MO
authors.lastname: Samoilov
mesh_terms: D000531:Altitude; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D000860:Hypoxia; D019194:Ischemic Preconditioning; D008297:Male; D009474:Neurons / Q000378:metabolism; D009833:Olfactory Pathways / Q000473:pathology*; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors