Diffusion MRI for prediction of response of rectal cancer to chemoradiation.
Prediction of tumour response before onset of treatment could have considerable clinical benefit. Since the apparent diffusion coefficient (ADC) of a tumour's water content can show the extent of necrosis, we looked for a possible correlation of ADC with response to treatment. We measured mean tumour water ADC before and after chemotherapy and chemoradiation in 14 patients with locally advanced rectal cancer, with a quantitative magnetic resonance diffusion imaging sequence. We found a strong negative correlation between mean pretreatment tumour water ADC and percentage size change of tumours after chemotherapy (r=-0.67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour.
Dzik-Jurasz
Andrzej
A
UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK. andrzej@icr.ac.uk
Domenig
Claudia
C
George
Mark
M
Wolber
Jan
J
Padhani
Anwar
A
Brown
Gina
G
Doran
Simon
S
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001834:Body Water / Q000187:drug effects; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D016896:Treatment Outcome
D000970:Antineoplastic Agents