Understanding dorsoventral topography: backwards and forwards.
Retinal axons project to their central targets along two orthogonal topographic axes, anterior-posterior (A-P) and dorsal-ventral (D-V). While ephrin-A/EphA signaling determines A-P topography, little has been known about the molecular mechanisms guiding axons along the D-V axis. Two papers by Mann et al. and Hindges et al. in this issue of Neuron provide evidence for both forward and reverse ephrin-B/EphB signaling in regulating D-V topography.
Pittman
Andrew
A
Program in Neuroscience and Department of Neurobiology and Anatomy, University of Utah Medical Center, 20 North 1900 East, Salt Lake City, UT 84132, USA.
Chien
Chi-Bin
CB
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D036387:Ephrin-B1; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D008565:Membrane Proteins / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D036081:Receptors, Eph Family; D012160:Retina / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D013477:Superior Colliculi / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D014795:Visual Pathways / Q000166:cytology / Q000196:embryology* / Q000378:metabolism
D036387:Ephrin-B1; D008565:Membrane Proteins; D020794:Receptor Protein-Tyrosine Kinases; D036081:Receptors, Eph Family