Common and differential mechanisms of gonadotropin receptors.
The gonadotropin receptors are G-protein-coupled receptors with unique structural and functional features, consisting of two halves. The N-terminal extracellular half (exodomain) binds the hormones, whereas the C-terminal membrane-associated half (endodomain) is responsible for receptor activation. In this review, the novel ternary interactions, contact points and mutual modulations among the exodomain, endodomain and hormone for hormone binding and signal generation are described based on the latest observations. This discussion is contrary to the yiew that the exodomain and endodomain are independent, at least functionally, and provides new insights into the receptor mechanisms for the gonadotropins and other G-protein-coupled receptors.
Yi
C S
CS
Department of Chemistry, University of Kentucky, Lexington 40506-0055, USA.
Song
Y S
YS
Ryu
K S
KS
Sohn
J
J
Ji
I
I
Ji
T H
TH
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011967:Receptors, Gonadotropin / Q000737:chemistry / Q000502:physiology*; D013329:Structure-Activity Relationship
D011967:Receptors, Gonadotropin