Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.
The importance of CD8 T cells in the pathogenesis of organ-specific autoimmune diseases has not previously been well recognized. Recent evidence, however, indicates that autoreactive CD8 T cells can contribute substantially to tissue damage in both murine and human autoimmune disorders. As such, these T cells now become an attractive target for therapeutic intervention.
Liblau
Roland S
RS
INSERM U563 and Immunology Laboratory, Toulouse University Hospital, France.
Wong
F Susan
FS
Mars
Lennart T
LT
Santamaria
Pere
P
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D015551:Autoimmunity; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016503:Drug Delivery Systems; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D009928:Organ Specificity