Oxidative induction of beta-turn conformations in cyclic peptidomimetics: conformational analyses as indicators of configuration.
Solid-phase syntheses of the cyclic peptidomimetics 1-4 were performed. Sulfide 1 and sulfoxide 3 did not tend to exist in beta-turn conformations in solution, but the sulfone 2 and the epimeric sulfoxide 4 did. The assignment of configuration of the sulfoxides is based on the conformational analyses.
Jiang
Luyong
L
Department of Chemistry, Texas A&M University, PO Box 30012, College Station, Texas 77842-3012, USA.
Burgess
Kevin
K
D002942:Circular Dichroism; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008715:Methionine / Q000737:chemistry; D008958:Models, Molecular; D018716:Molecular Mimicry; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation
D007202:Indicators and Reagents; D010455:Peptides; D008715:Methionine