title: Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium.
abstract: The protecting effect of betulin against cadmium toxicity was investigated using 11 kinds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Japan. hiroya@mail.cc.tohoku.ac.jp
authors.forename: Kou
authors.initials: K
authors.lastname: Hiroya
authors.forename: Taisuke
authors.initials: T
authors.lastname: Takahashi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Miura
authors.forename: Akira
authors.initials: A
authors.lastname: Naganuma
authors.forename: Takao
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D002104:Cadmium / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D020011:Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D000094062:Betulinic Acid
chemical_list: D002104:Cadmium; D020011:Protective Agents; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid