Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease.
The Stroop Color-Word Test (SCWT; C. Golden, 1978) was examined in 59 patients with probable Alzheimer's disease (AD) and in 51 demographically comparable normal control (NC) participants. AD patients produced significantly larger Stroop interference effects than NC participants, and level of dementia severity significantly influenced SCWT performance. Principal-components analyses demonstrated a dissociation in the factor structure of the Stroop trials between NC participants and AD patients, suggesting that disruption of semantic knowledge and speeded verbal processing in AD may be a major contributor to impairment on the incongruent trial. Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance.
Bondi
Mark W
MW
Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California 92161, USA. mbondi@ucsd.edu
Serody
Adam B
AB
Chan
Agnes S
AS
Eberson-Shumate
Sonja C
SC
Delis
Dean C
DC
Hansen
Lawrence A
LA
Salmon
David P
DP
D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis*; D003118:Color Perception / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis; D016015:Logistic Models; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000503:physiopathology; D012660:Semantics; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000503:physiopathology