title: Therapeutic aspects of brain tissue pO2 monitoring after subarachnoid hemorrhage.
abstract: Prolonged phases of brain tissue hypoxia (ptiO2 < 10 mmHg) lead to cerebral infarction. Therefore, the present study investigates the role of ptiO2--monitoring to guide hypervolemic hypertensive therapy in patients suffering from severe subarachnoid hemorrhage (SAH). Besides transcranial doppler, neuromonitoring of ICP/CPP was supplemented by ptiO2 monitoring. The ptiO2 catheter was inserted into viable tissue in the vascular territory with the highest risk for vasospasm. Patients were divided in an infarction (n = 21) and a non-infarction group (n = 11). Critical CPP (< 70 mmHg) as well as hypoxic ptiO2 (< 10 mmHg) was significantly more frequent in the infarction group (CPP: 25 vs 13%, p < 0.001; ptiO2: 16 vs 7%, p < 0.001). In both groups, over 25% of the critical ptiO2 values occurred at a CPP > 90 mmHg. In the infarction group, 13 patients showed transient phases of hypoxia which normalized under induced hypervolemic hypertension and 5 patients developed persistent hypoxia. In the non-infarction group 6 patients showed transient hypoxia and in 5 patients no hypoxic values could be found. In conclusion, monitoring of ptiO2 provides an additional independent parameter to detect hypoxic events and to guide therapy.
authors.affiliation: Department of Neurosurgery, University of Würzburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Väth
authors.forename: E
authors.initials: E
authors.lastname: Kunze
authors.forename: K
authors.initials: K
authors.lastname: Roosen
authors.forename: J
authors.initials: J
authors.lastname: Meixensberger
mesh_terms: D015687:Cell Hypoxia; D002544:Cerebral Infarction / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D002534:Hypoxia, Brain / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D007427:Intracranial Pressure / Q000502:physiology*; D008991:Monitoring, Physiologic / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D013997:Time Factors; D020301:Vasospasm, Intracranial / Q000517:prevention & control
chemical_list: D010100:Oxygen