Non-peptide opioid receptor ligands - recent advances. Part II - antagonists.
This paper is the second part of the review on opioid receptor ligands and deals with the progress in the field of non-peptide opioid receptor antagonists (starting from the pioneering opiate studies in the early seventies) with particular stress on the last decade accomplishments. As X-ray high resolution structure determination of the ligand-receptor systems for G protein-coupled receptors meets with considerable experimental obstacles, the knowledge about ligand interactions with the membrane-bound receptors traditionally derives from structure-activity studies. Hence, such a concise summary, collecting chemically distinct but pharmalogically relative compounds, may be a convenient information source for any research concerning ligand-opioid receptor binding or rational drug design.
Kaczor
Agnieszka
A
Department of Synthesis and Technology of Drugs, Faculty of Pharmacy, Medical University at Lublin, 6 Staszica Str., Lublin, PL-20081, Poland. darek@eskulap.am.lublin.pl
Matosiuk
Dariusz
D
D000818:Animals; D001665:Binding Sites; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D009020:Morphine / Q000737:chemistry / Q000494:pharmacology; D009292:Narcotic Antagonists; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology; D011957:Receptors, Opioid / Q000737:chemistry / Q000145:classification; D013329:Structure-Activity Relationship
D007546:Isoquinolines; D008024:Ligands; D009292:Narcotic Antagonists; D010879:Piperazines; D010880:Piperidines; D011804:Quinolines; D011957:Receptors, Opioid; D009020:Morphine