[Parvovirus B19 myocarditis in a young man with previous non-bacterial meningitis].
METHODS
A 22-year old man presented with fatigue, dyspnea NYHA III and presyncopes that had persisted since a non-bacterial meningitis 3 months before.


METHODS
Transthoracic echocardiography revealed a dilated left ventricle with an ejection fraction (EF) reduced to 35-40 % due to global hypokinesia. No pericardial effusion was seen; ECG and lung function test were normal. Serological, immunological and microbiological tests as well as nested PCR analysis of blood leucocytes for detection of cardiotropic pathogens were inconclusive. In endomyocardial biopsies retrieved from the left ventricular posterolateral wall, a chronic macro-phage-rich myocarditis was shown by histopathology and, in addition, Parvovirus B19 was identified as specific pathogen by use of nested PCR analysis.


METHODS
At physical rest and with ACE inhibitor therapy (2.5 mg ramipril/day), heart failure decreased steadily. Follow-up echocardiography 1 month later revealed a left ventricle that was only slightly dilated with an EF of 50 %. 3 months later, the patient was markedly more load-bearing; the EF amounted to 55-60 %.


CONCLUSIONS
Parvovirus B19 should be regarded as potential pathogen in case of suspected myocarditis in adulthood. Whether the previous non-bacterial meningitis was also attributable to this specific pathogen, remains open. Of note, however, the present case report by demonstrating a localized myocardial Parvovirus B19 infection without detectable systemic infection underscores the importance of molecular tests for diagnostic accuracy in manifest organ failure.
Düx
S
S
Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn.
Lentini
S
S
Bock
C T
CT
Klingel
K
K
Kandolf
R
R
Bauriedel
G
G
D000328:Adult; D001706:Biopsy; D004279:DNA, Viral / Q000235:genetics; D004699:Endocardium / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D009205:Myocarditis / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D009206:Myocardium / Q000473:pathology; D010322:Parvoviridae Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000473:pathology / Q000821:virology
D004279:DNA, Viral