title: [Life expectancy and aging, scientific and medical aspects].
abstract: STUDIES ON THE BIOLOGY OF AGING: According to species demonstrate the role of certain synchronizers, such as calory restrictions, genetic modifications and environmental and living conditions. FUNCTIONAL OR PROTEIN GENOMICS: Are aimed at listing the human proteins and their localization. Study of the variations in proteome according to age has also been envisaged. Research on chronic (cardiovascular, and neurodegenerative or metabolic) diseases with multifactor causes (related both to environmental conditions and genetic sensitivity) must be accelerated. CELL SENESCENCE: Is expressed by the blocking of the mitosis signal, with modification in gene expression, and alteration in phenotype; it could be an anti-cancer mechanism, like apoptosis. THERE IS AN OBVIOUS RELATIONSHIP BETWEEN AGING AND CANCER: However the latter is not a consequence of aging, even if the absence of telomerase (enzyme maintaining DNA length) is observed in both cases. TO PERMIT HARMONIOUS AND GOOD QUALITY AGING: It is essential to intensify the screening and prevention of deficiencies and pathological phenomena in elderly subjects, notably cerebral aging and dementia, cardiovascular aging, osteo-articular diseases....
authors.forename: Marie
authors.initials: M
authors.lastname: Solignac
mesh_terms: D000375:Aging / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D008017:Life Expectancy / Q000639:trends*; D008136:Longevity; D008938:Mitosis; D009369:Neoplasms / Q000453:epidemiology; D020543:Proteome; D011788:Quality of Life
chemical_list: D020543:Proteome