title: [Occupational asthma due to hard metals hypersensitivity].
abstract: The authors report the case of a worker in the hard metal industry presenting with asthma due to cobalt and nickel. The diagnosis was supported by the history, positive skin tests and lymphocyte activation as well as elevated levels of the metals in the urine and BAL. Challenge led to a delayed asthmatic reaction occurring 3.5 to 24 hours after exposure. The BAL contained high levels of tungsten and cobalt, the level of the latter doubling 48 hours after exposure. After the provocation test a nasal and broncho-alveolar eosinophilia was observed. The possibility of a delayed hypersensitivity reaction to metals is discussed by the authors.
authors.affiliation: Service de Médecine Interne, Immunologie Clinique et Allergologie, Hôpital central, 29 avenue Maréchal de Lattre de Tassigny, 54000 Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: De Hauteclocque
authors.forename: M
authors.initials: M
authors.lastname: Morisset
authors.forename: G
authors.initials: G
authors.lastname: Kanny
authors.forename: C
authors.initials: C
authors.lastname: Kohler
authors.forename: B
authors.initials: B
authors.lastname: Mouget
authors.forename: D A
authors.initials: DA
authors.lastname: Moneret-Vautrin
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D003035:Cobalt / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000209:etiology; D009532:Nickel / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced*; D014414:Tungsten / Q000009:adverse effects*
chemical_list: D003035:Cobalt; D009532:Nickel; D014414:Tungsten