Antioxidant enzyme determination and a study of lipid peroxidation in renal transplantation.
The aim of this study was to evaluate the antioxidant enzymes, catalase (CAT) and superoxide dismutase (SOD), in renal transplant patients and at the same time to report on the degree of lipid peroxidation observed in these patients. In order to do so we measured erythrocyte malondialdehyde (MDA), a product of lipid peroxidation. These measurements were made at different times: before the transplant, 48 h after the transplant, a week after the transplant and two weeks after the transplant. The values reported were compared with a control group. The results showed that there was a higher MDA level in the transplant group than in the control group one week after the transplant. In addition, two weeks after the transplant, the activities of CAT and SOD were higher in the transplant group than in the control group.
Pérez Fernandez
R
R
Department of Biochemistry, Science School, University of Valladolid, Spain.
Martín Mateo
M C
MC
De Vega
L
L
Bustamante Bustamante
J
J
Herrero
Mendiluce
M
Bustamante Munguira
E
E
D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000201:enzymology / Q000628:therapy; D016030:Kidney Transplantation; D015227:Lipid Peroxidation / Q000502:physiology*; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D012189:Retrospective Studies; D013030:Spain; D013482:Superoxide Dismutase / Q000378:metabolism*; D016896:Treatment Outcome
D000975:Antioxidants; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase