[Protective electrophysiological effects of somatostatin in patients with paroxysmal atrioventricular reciprocal tachycardias].
Within 30 seconds after intravenous injection of somatostatin (sandostatin, 0.1 mg) we observed restoration of sinus rhythm in patients with atrioventricular (AV) junctional or orthodromic reciprocal tachycardias. This action was associated with interruption of re-entry on anterograde direction of AV conductivity. Somatostatin elicited pronounced cardiac electrophysiological effects which were due to activation of parasympathetic nervous system. Besides, it evoked transient elevation of systolic (+12.6%) and diastolic (+13.5%) blood pressures. High efficacy and good tolerance of somatostatin allow to consider this peptide as an alternative to adenosine and verapamil in the treatment of AV reciprocal tachycardias.
Kanorskií
S G
SG
Osadchií
O E
OE
Skibitskií
V V
VV
Pokrovskií
V M
VM
D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004594:Electrophysiology / Q000379:methods; D005260:Female; D006321:Heart / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000627:therapeutic use*; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000188:drug therapy; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy*
D000889:Anti-Arrhythmia Agents; D013004:Somatostatin