title: Regional radioactivity discrepancy between Tc-99m GSA and Tc-99m phytate liver scans in a patient with massive hepatic necrosis.
abstract: A 22-year-old woman with severe acute hepatitis underwent a Tc-99m galactosyl human serum albumin (GSA) scan. Intense accumulation was observed in the cephalic region of the right hepatic lobe, whereas the accumulation was reduced in the left lobe and the caudal region of the right lobe. A computed tomographic (CT) scan showed that the left lobe and the caudal region of the right posterior segment had atrophied and become hypodense, which were thought to represent postnecrotic scarring after massive hepatic necrosis. The relatively hyperdense region in the right lobe was slightly swollen and was thought to represent regenerating liver tissue or a "potato liver." Compared with the CT, the regions of elevated Tc-99m GSA accumulation correlated well with the areas of regenerating liver tissue, and the regions with reduced accumulation corresponded closely with the areas of postnecrotic scarring. On a Tc-99m phytate scan, unlike the Tc-99m GSA scan, the radiocolloid accumulation was intense in the left lobe and caudal region of the right lobe and reduced in the cephalic region of the right lobe. Together, the Tc-99m GSA scan and the Tc-99m phytate scan formed a set of exact "nega-posi" images. Biopsy specimens obtained during laparoscopy showed a few hepatocyte columns in the postnecrotic scarred left lobe. Severe disruption of the hepatocytes, prominent inflammatory cell infiltration, and obvious Kupffer cell hypertrophy and clustering were also observed.
authors.affiliation: Department of Radiology, Okayama University Medical School, Okayama, Japan. akaki@cc.okayama-u.ac.jp
authors.forename: Shiro
authors.initials: S
authors.lastname: Akaki
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Saeki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Iguchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okumura
authors.forename: Shuhei
authors.initials: S
authors.lastname: Sato
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kuroda
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Toshio
authors.initials: T
authors.lastname: Uraoka
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Baba
authors.forename: Kosaku
authors.initials: K
authors.lastname: Sakaguchi
mesh_terms: D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006505:Hepatitis / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007728:Kupffer Cells / Q000473:pathology; D010535:Laparoscopy; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; C026177:technetium phytate; D010833:Phytic Acid; D016284:Technetium Tc 99m Pentetate