Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study.
OBJECTIVE
To quantify the association between olanzapine and diabetes.


METHODS
Population based nested case-control study.


METHODS
United Kingdom based General Practice Research Database comprising 3.5 million patients followed between 1987 and 2000.


METHODS
19 637 patients who had been diagnosed as having and treated for schizophrenia. 451 incident cases of diabetes were matched with 2696 controls.


METHODS
Diagnosis and treatment of diabetes.


RESULTS
Patients taking olanzapine had a significantly increased risk of developing diabetes than non-users of antipsychotics (odds ratio 5.8, 95% confidence interval 2.0 to 16.7) and those taking conventional antipsychotics (4.2, 1.5 to 12.2). Patients taking risperidone had a non-significant increased risk of developing diabetes than non-users of antipsychotics (2.2, 0.9 to 5.2) and those taking conventional antipsychotics (1.6, 0.7 to 3.8).


CONCLUSIONS
Olanzapine is associated with a clinically important and significant increased risk of diabetes.
Koro
Carol E
CE
Pharmaceutical Health Services Research Department, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.
Fedder
Donald O
DO
L'Italien
Gilbert J
GJ
Weiss
Sheila S
SS
Magder
Laurence S
LS
Kreyenbuhl
Julie
J
Revicki
Dennis A
DA
Buchanan
Robert W
RW
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D016022:Case-Control Studies; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000139:chemically induced*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects* / Q000031:analogs & derivatives; D012044:Regression Analysis; D012307:Risk Factors; D018967:Risperidone / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D018967:Risperidone; D000077152:Olanzapine