In vitro antiphagocytic effect of basil oil on mouse macrophages.
The effect of basil oil on the phagocytic capability and respiratory burst response of mouse peritoneal macrophages was studied. The oil inhibited the phagocytosis of opsonized sheep erythrocytes. This inhibition was both dose- and time-dependent and reverted 24 h after removing the extract from the culture medium. On the other hand, the oil showed no effect on concanavalin A and lipopolysaccharide-induced proliferation.
Courrèges
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MC
Experimental Pathology, Department of Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina. cecu@hotmail.com
Benencia
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D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D031339:Ocimum; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects; D012756:Sheep; D015054:Zymosan / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D010938:Plant Oils; D015054:Zymosan; C051168:basil oil