A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection.
Waegell
W
W
Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA.
Babineau
M
M
Hart
M
M
Dixon
K
K
McRae
B
B
Wallace
C
C
Leach
M
M
Ratnofsky
S
S
Belanger
A
A
Hirst
G
G
Rossini
A
A
Appel
M
M
Mordes
J
J
Greiner
D
D
Banerjee
S
S
D000818:Animals; D000831:Animals, Newborn; D016207:Cytokines / Q000096:biosynthesis; D003921:Diabetes Mellitus, Experimental / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016038:Skin Transplantation / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
D016207:Cytokines; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)