title: Human immunodeficiency virus (HIV)-specific antibody in cervicovaginal lavage specimens obtained from women infected with HIV type 1.
abstract: To evaluate correlates of anti-human immunodeficiency virus (HIV) type 1 (HIV-1) immunoglobulin (Ig) in the genital tract, anti-HIV-gp120 IgA and IgG titers in cervicovaginal lavage specimens obtained from 104 HIV-1-infected women were measured by enzyme-linked immunosorbent assay. Overall, 24% and 94% of women had detectable anti-gp120 IgA and IgG, respectively. CD4 cell count correlated negatively with total IgA concentration (r=-0.301; P=.0027) and positively with specific IgA activity (anti-gp120 IgA titer/total IgA concentration, r=0.306; P=.0023). Women with bacterial vaginosis had 5-fold lower anti-gp120 IgG titer (P=.0042), 5-fold lower total IgG concentration (P< or =.0001), and 4-fold higher specific IgG activity (P=.0474) compared with women who did not have bacterial vaginosis. Enhanced understanding of correlates of mucosal immunity to HIV-1 may assist in the design of vaccine strategies or in the prevention of vertical transmission of HIV-1.
authors.affiliation: Department of Medicine, Brown University School of Medicine, Providence, RI 02906, USA.
authors.forename: Selvi B
authors.initials: SB
authors.lastname: Williams
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Flanigan
authors.forename: Susan
authors.initials: S
authors.lastname: Cu-Uvin
authors.forename: Kenneth
authors.initials: K
authors.lastname: Mayer
authors.forename: Pepper
authors.initials: P
authors.lastname: Williams
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Ettore
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Artenstein
authors.forename: Ann
authors.initials: A
authors.lastname: Duerr
authors.forename: Thomas C
authors.initials: TC
authors.lastname: VanCott
mesh_terms: D000328:Adult; D000918:Antibody Specificity; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008875:Middle Aged; D013223:Statistics as Topic
chemical_list: D015699:HIV Envelope Protein gp120; D007070:Immunoglobulin A; D007074:Immunoglobulin G