title: Supplementing bovine milk immunoglobulin G prevents rats fed on a vitamin E-deficient diet from developing peroxidation stress.
abstract: OBJECTIVE
  Bovine milk whey, which mainly includes beta-lactoglobulin (58%), alpha-lactalbumin (22%) and immunoglobulin G (IgG; 11%), is a source of a wide range of proteins with a useful nutritional and physiological function. We previously demonstrated antiperoxidative effects of whey-derived alpha-lactalbumin and beta-lactoglobulin in rats. The aim of the present study was to investigate the role of the IgG in antiperoxidative properties.
  
  
  METHODS
  Four-week-old, male Sprague-Dawley rats were fed a vitamin E-deficient diet (control) or a diet supplemented with 2.5% of an IgG-rich fraction for 4 weeks. Different antiperoxidative parameters were measured in blood and liver from the rats.
  
  
  RESULTS
  In comparison to the rats fed the control diet, those fed the IgG-containing diet were resistant to peroxidation stress. The IgG diet resulted in a decreased concentration of thiobarbituric acid-reactive substances in red blood cells (RBC) and plasma, and increased activities of catalase, superoxide dismutase and glutathione peroxidase in the RBC and liver. The plasma density (d) < 1.063 g/ml lipoproteins from the IgG group were more resistant against the induced lipid peroxidation.
  
  
  CONCLUSIONS
  These results demonstrate antiperoxidative properties of IgG. The underlying mechanism(s) remain to be determined.
authors.affiliation: Graduate School of Bioresource and Bioenvironmental Sciences, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, Japan.
authors.forename: Mohsen A
authors.initials: MA
authors.lastname: Zommara
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Toubo
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imaizumi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000097:blood; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006454:Hemoglobins / Q000187:drug effects; D007074:Immunoglobulin G / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000201:enzymology* / Q000378:metabolism*; D008297:Male; D008892:Milk; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000150:complications*; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D006454:Hemoglobins; D007074:Immunoglobulin G; D008055:Lipids; D008074:Lipoproteins; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D024502:alpha-Tocopherol