[Hydroxy(aryl)methylene]diphosphonic acids, a class of drugs in bone pathology treatments, crystallize as head-to-head dimers.
Two [hydroxy(aryl)methylene]diphosphonic acids have been crystallized as dimers. The first compound, [hydroxy(phenyl)methylene]diphosphonic acid monohydrate, C(7)H(10)O(7)P(2).H(2)O, crystallizes in the non-centrosymmetric space group P2(1), with the two enantiomers related by a non-crystallographic centre of inversion, while the second compound, [hydroxy(4-nitrophenyl)methylene]diphosphonic acid tetrahydrofuran disolvate, C(7)H(9)NO(9)P(2).2C(4)H(8)O, crystallizes in the centrosymmetric space group P2(1)/c and uses the centre of symmetry to form the same dimer.
Lecouvey
Marc
M
Chimie Structurale et Spectroscopie Biomoléculaire, UMR 7033-CNRS, 74 rue M. Cachin, 93017 Bobigny Cedex, France.
Barbey
Carole
C
Navaza
Alda
A
Neuman
Alain
A
Prangé
Thierry
T
D001847:Bone Diseases / Q000188:drug therapy*; D018360:Crystallography, X-Ray; D004164:Diphosphonates / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular
D004164:Diphosphonates