Catalytic diastereoselective reductive claisen rearrangement.
[reaction: see text] A catalytic amount of [(cod)RhCl](2) and MeDuPhos initiates an ester enolate Claisen rearrangement with good yields and diastereocontrol. Reaction conditions are mild and tolerant of base-sensitive functionality.
Miller
Steven P
SP
Department of Chemistry, Venable and Kenan Laboratories, The University of North Carolina at Chapel Hill, 27599-3290, USA.
Morken
James P
JP
D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism
D001555:Benzene Derivatives