Cranial nerve function in workers exposed to polychlorinated dioxins and furans.
OBJECTIVE
To look for possible effects of polychlorinated dioxins and furans (PCDD/F) on cranial nerve function.


METHODS
Clinical and neurophysiological examinations [visual and brainstem auditory evoked potentials (VEP and BAEP), blink reflex] in 121 PCDD/F exposed workers of one pesticide producing plant.


RESULTS
BAEP abnormalities were more frequent in workers with chloracne (6 of 33 workers, 18.2%) than in those without chloracne (7 of 84, 8.3%), but this was not statistically significant (chi2: 2.33). VEP abnormalities were seen in one worker with and two without chloracne. Clinically visual functions were normal except in one worker, who was amaurotic since birth. Blink reflex abnormalities without corresponding clinical findings were observed in two patients without chloracne.


CONCLUSIONS
Severe exposure to PCDD/F is not followed by clinical signs of cranial nerve dysfunction but may create an increased risk for abnormal BAEP findings, which were more than twice as common in workers with chloracne. Although this difference did not reach statistical significance, it cannot exclude a toxic effect of PCDD/F, as statistical significance is difficult to achieve with such small numbers of workers. In none of the workers, BAEP abnormalities were accompanied by clinical signs of hearing dysfunction.
Thömke
F
F
Department of Neurology, University of Mainz, Germany. thoemke@neurologie.klinik.uni-mainz.de
Jung
D
D
Besser
R
R
Röder
R
R
Konietzko
J
J
Hopf
H C
HC
D000328:Adult; D000368:Aged; D001767:Blinking; D002617:Chemical Industry; D003391:Cranial Nerves / Q000503:physiopathology*; D004147:Dioxins / Q000009:adverse effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D005663:Furans / Q000009:adverse effects*; D006309:Hearing / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000150:complications; D016273:Occupational Exposure; D012018:Reflex / Q000187:drug effects
D004147:Dioxins; D005663:Furans