title: Selenium intakes, absorption, retention, and status in adolescent girls.
abstract: OBJECTIVE
  To assess selenium intakes, absorption, retention, and status in healthy adolescent girls and the effect of calcium supplementation on selenium parameters.
  
  
  METHODS
  Annual 2-week study conducted each year for 3 consecutive years in which yearly selenium intakes, absorption, and retention and blood selenium status were measured.
  
  
  METHODS
  A metabolic unit in a large metropolitan hospital located in Columbus, Ohio--a low selenium region of the United States.
  
  
  METHODS
  Healthy white girls aged 11 to 14 years (n=16) enrolled in a calcium balance study and randomly assigned to receive a placebo of methylcellulose (n=9) or a calcium supplement containing 1,000 mg supplemental calcium as calcium citrate malate (n=7).
  
  
  METHODS
  Each subject consumed a diet with approximately 100 microg selenium/day during the yearly 2-week balance studies.
  
  
  RESULTS
  Selenium status measurements (serum and erythrocyte selenium and glutathione peroxidase activity) were all within normal ranges for adults during the study. Apparent selenium absorption averaged 71%, 76%, and 74% for years 1, 2, and 3 of the study, respectively, and did not vary significantly (P>.05). Average daily selenium retention did not differ among the years of the study (P>.05) and indicated that the usual selenium intake was approximately 100 microg daily. Measurements of selenium status and retention did not differ between calcium-supplemented and placebo groups.
  
  
  CONCLUSIONS
  An intake of approximately 100 microg selenium/day is the typical intake of the mineral among the subjects and appeared adequate to maintain selenium status in these healthy adolescent girls; in addition, calcium supplementation of 1,000 mg daily does not have a negative impact on selenium parameters.
authors.affiliation: Department of Human Nutrition and Food Management, The Ohio State University, Columbus, USA. holben@ohio.edu
authors.forename: David H
authors.initials: DH
authors.lastname: Holben
authors.forename: Anne M
authors.initials: AM
authors.lastname: Smith
authors.forename: Jasminka Z
authors.initials: JZ
authors.lastname: Ilich
authors.forename: John D
authors.initials: JD
authors.lastname: Landoll
authors.forename: John P
authors.initials: JP
authors.lastname: Holcomb
authors.forename: Velimir
authors.initials: V
authors.lastname: Matkovic
mesh_terms: D000293:Adolescent; D017195:Adolescent Nutritional Physiological Phenomena; D001682:Biological Availability; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D002648:Child; D015930:Diet Records; D019587:Dietary Supplements; D004912:Erythrocytes / Q000737:chemistry / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D008137:Longitudinal Studies; D015596:Nutrition Assessment; D009752:Nutritional Status; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D002136:Calcium, Dietary; D005979:Glutathione Peroxidase; D012643:Selenium