title: Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1.
abstract: ZNF333 is a novel human KRAB-zinc finger protein gene on chromosome 19p13.1 encompassing 14 exons. ZNF333 is highly expressed in heart and encodes a 665 amino acid protein that contains a rare combination of double KRAB-domains, each consisting of a classical KRAB-A and a highly divergent KRAB-B box at the N-terminus. ZNF333 further contains 10 C2H2 zinc finger motifs at the C-terminus.
authors.affiliation: Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Tian
authors.forename: Guido J
authors.initials: GJ
authors.lastname: Breedveld
authors.forename: Shangzhi
authors.initials: S
authors.lastname: Huang
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Peter
authors.initials: P
authors.lastname: Heutink
authors.forename: Wilson H Y
authors.initials: WH
authors.lastname: Lo
mesh_terms: D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D005091:Exons; D006801:Humans; D007438:Introns; D051741:Kruppel-Like Transcription Factors; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000096:biosynthesis; D016415:Sequence Alignment; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D016335:Zinc Fingers
chemical_list: D002352:Carrier Proteins; D051741:Kruppel-Like Transcription Factors; D012333:RNA, Messenger; D014157:Transcription Factors; C465632:ZNF333 protein, human