Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia.
Several studies, including one from Japan, have observed an increase of Human Leukocyte Antigen (HLA)-A24 and A26 in schizophrenia, although others failed to observe the increase. No use of systematic diagnostic criteria and a not-adequately reliable typing technique might have affected the results in the previous studies. We investigated HLA-A specificities in Japanese patients with schizophrenia (DSM-IV), recruited from the same area as in the early Japanese study. A DNA-based technique (polymerase chain reaction-microtiter plate hybridization) was employed. No significant difference was observed in frequencies of any HLA-A specificities between patients and controls, including A24 and A26. No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.
Tochigi
Mamoru
M
Department of Psychiatry, Haryugaoka Hospital, 11 Tensyodan, Otsuki-machi, Koriyama City, Fukushima 963-0201, Japan.
Ohashi
Jun
J
Umekage
Tadashi
T
Kohda
Kazuhisa
K
Hibino
Hiroyuki
H
Otowa
Takeshi
T
Marui
Tetsuya
T
Masui
Kanji
K
Sugahara
Yuriko
Y
Kanamori
Ryo
R
Juji
Takeo
T
Kato
Nobumasa
N
Tokunaga
Katsushi
K
Sasaki
Tsukasa
T
D000328:Adult; D016009:Chi-Square Distribution; D000939:Epitopes / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics*; D059871:HLA-A24 Antigen; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D012621:Seasons
D000939:Epitopes; D015234:HLA-A Antigens; C039683:HLA-A*26 antigen; D059871:HLA-A24 Antigen