Human Meissner corpuscles express Bcl-2 but not Bax protein.
Bcl-2 and Bax proteins play major roles in the control of apoptosis. The Bcl-2/Bax ratio is considered a marker of a cell's susceptibility to apoptotic stimuli. Immunohistochemical expression of Bcl-2 and Bax in Meissner corpuscles was investigated in 30 human skin samples. All of the Meissner corpuscles showed immunoreactivity for Bcl-2 and Bax was negative. These data support a role for Bcl-2 as a resistance mechanism of these mechanoreceptors to apoptosis.
Ortiz-Rey
José A
JA
Department of Pathology, POVISA Centro Médico, Vigo (Pontevedra), Spain. jaortiz@povisa.es
Alvarez-Alvarez
Carlos
C
Antón-Badiola
Iosu
I
San Miguel-Fraile
Pilar
P
De la Fuente-Buceta
Ana
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008465:Mechanoreceptors / Q000378:metabolism*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein