Oxaliplatin loaded PLAGA microspheres: design of specific release profiles.
Oxaliplatin loaded PLAGA microspheres have been prepared by solvent extraction process. Parameters affecting the release kinetics in vitro have been studied in order to design specific release profiles suitable for direct intra-tumoral injection. By varying the nature and the relative proportions of different polymers we managed to prepare microspheres with good encapsulation efficiency (75-90%) and four different release profiles: zero order kinetics (type II) and the classical sigmoïd release profile with three different sizes of plateau and burst. These results, if correlated with in vivo activity, are promising to enhance effectiveness of local tumor treatment.
Lagarce
F
F
INSERM ERIT-M 0104, Batiment IBT, 10, rue A. Boquel, 49100, Angers, France.
Cruaud
O
O
Deuschel
C
C
Bayssas
M
M
Griffon-Etienne
G
G
Benoit
J
J
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005079:Excipients; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D000077150:Oxaliplatin; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D012995:Solubility
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D009944:Organoplatinum Compounds; D011108:Polymers; D000077150:Oxaliplatin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid