title: Enhanced contact activity of fluconazole in association with antioxidants against fluconazole-resistant organisms.
abstract: Fluconazole alone does not demonstrate any contact activity against resistant organisms. Phenolic antioxidants, such as butylated hydroxyanisole, appear to promote fluconazole activity resulting in the killing of 10(4) cfu/mL of 11 resistant Candida albicans strains within 3-15 min and of 10(4) cfu/mL of 10 resistant Escherichia coli strains within 6-15 min. Fluconazole activity was increased by the addition of ethyl alcohol (20%). Antioxidants appear to promote fluconazole activity by increasing cell membrane permeability. This combination has potential advantages in the administration of topical fluconazole.
authors.affiliation: University of Rome La Sapienza, Institute of Microbiology, Faculty of Pharmacy, Piazzale Aldo Moro 5, 00185 Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
authors.forename: A
authors.initials: A
authors.lastname: Villa
authors.forename: N
authors.initials: N
authors.lastname: Simonetti
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D025141:Drug Resistance, Fungal / Q000502:physiology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans
chemical_list: D000975:Antioxidants; D015725:Fluconazole