High correlation between salivary MHPG and CSF MHPG.
BACKGROUND
Determination of 3-methoxy-4-hydroxy-phenylglycol (MHPG) as a major metabolite of noradrenaline may reflect changes in noradrenergic activity dependent on psychiatric illness and drug therapy.


OBJECTIVE
This study was designed to investigate the relationship between CSF and salivary MHPG, and thus the utility of saliva MHPG as a marker for CSF MHPG.


METHODS
Twenty-one paired samples of saliva and CSF were assayed for MHPG by solid-phase extraction and HPLC-ED.


RESULTS
Salivary MHPG was highly positively correlated with CSF MHPG ( P<0.001).


CONCLUSIONS
This finding supports the use of salivary MHPG as an index for CSF MHPG, and enhances the usefulness of salivary MHPG measurements as a non-invasive approach for clinical studies investigating noradrenergic systems.
Reuster
Thomas
T
Department of Psychiatry, Neurobiological Section, Carl Gustav Carus Hospital, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany. Thomas.Reuster@mailbox.tu-dresden.de
Rilke
Olaf
O
Oehler
Jochen
J
D002855:Chromatography, Thin Layer / Q000379:methods; D006801:Humans; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis / Q000134:cerebrospinal fluid*; D012016:Reference Values; D015203:Reproducibility of Results; D012463:Saliva / Q000378:metabolism*
D008734:Methoxyhydroxyphenylglycol