Predominance of CRF02-AG and CRF06-cpx in Niger, West Africa.
A total of 110 HIV-1-positive samples obtained in 1997 (n = 44) and 2000 (n = 66) were genetically characterized in the V3-V5 envelope region and the p24 gag region. The majority of the strains were CRF02-AG (54.3%) or CRF06-cpx (18.1%) in env and gag. More than 9% of the samples were recombinants between CRF02 and CRF06; 9 were CRF06 in env but CRF02 in gag, and for one sample the opposite was seen. Overall for 23 (20.9%) samples, the subtype designation was different between env and gag, and in 20 of these 23 samples a CRF was involved in the recombination event. No significant differences were seen between subtype distributions in 1997 and 2000, except that the proportion of recombinants increased from 13.6% in 1997 to 27.2% in 2000.
Mamadou
Saidou
S
National Hospital of Niamey, Niamey, Niger.
Montavon
Celine
C
Ben
Aminata
A
Djibo
Ali
A
Rabiou
Sanata
S
Mboup
Souleymane
S
Delaporte
Eric
E
Peeters
Martine
M
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D005260:Female; D015752:Genes, env; D015750:Genes, gag; D016655:HIV Core Protein p24 / Q000235:genetics; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009549:Nigeria
D016655:HIV Core Protein p24