title: [A linkage analysis of quantitative trait loci for familial schizophrenia on chromosome 1].
abstract: OBJECTIVE
  To explore the molecular genetic relationship between chromosome 1 and quantitative trait loci for familial schizophrenia.
  
  
  METHODS
  A series of assessment scales included positive and negative syndrome scale (PANSS), global assessment of functional scale (GAFS), premorbid schizoid and schizotypal traits scale (PSST), premorbid social adjustment scale (PSA) were applied to quantify the phenotypes of schizophrenia. Non-parametric linkage analysis of quantitative traits was conducted in 32 multiplex pedigrees with schizophrenia by using 29 microsatellite makers on chromosome 1.
  
  
  RESULTS
  Haseman-Elston   quantitative trait analysis detected a maximum Traditional H-E Lods of 1.73 and a maximum EH H-E Lods of 1.65 of negative symptoms (PANSS-N ) at 147.64 cM, which was overlapped to the positive region of 1q21-23 in qualitative linkage analysis.
  
  
  CONCLUSIONS
  The results suggest there might be an independent quantitative trait locus of negative symptoms on 1q21-23 for familial schizophrenia.
authors.affiliation: Department of Forensic Medicine, Zhongshan Medical College   Sun Yat-Sen University, Guangzhou, Guangdong, 510080 P.R. China. caiguiqing@163.com
authors.forename: Guiqing
authors.initials: G
authors.lastname: Cai
authors.forename: Xinyao
authors.initials: X
authors.lastname: Wu
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: David A
authors.initials: DA
authors.lastname: Collier
authors.forename: Xiehe
authors.initials: X
authors.lastname: Liu
authors.forename: Bingjian
authors.initials: B
authors.lastname: Feng
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
authors.forename: Dayue
authors.initials: D
authors.lastname: Tong
authors.forename: Jianjin
authors.initials: J
authors.lastname: Li
authors.forename: Jinghua
authors.initials: J
authors.lastname: Ou
mesh_terms: D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005192:Family Health; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats; D019655:Quantitative Trait, Heritable; D012559:Schizophrenia / Q000235:genetics*