title: The effect of fluoride and hypothermia on the in vitro metabolism of mivacurium.
abstract: The fluoride inhibition of mivacurium hydrolysis by pseudocholinesterase increases in hypothermia, but it will very rarely occur in clinical practice because it requires rather large fluoride concentrations (>50 micromol/L) and very low temperatures (<28 degrees C).
authors.affiliation: Department of Anesthesiology, University of Regensburg, Regensburg, Germany. michael.gruber@klinik.uni-regensburg.de
authors.forename: Michael
authors.initials: M
authors.lastname: Gruber
authors.forename: Regina
authors.initials: R
authors.lastname: Lindner
authors.forename: Christopher
authors.initials: C
authors.lastname: Prasser
authors.forename: Gunther
authors.initials: G
authors.lastname: Wiesner
mesh_terms: D000328:Adult; D002091:Butyrylcholinesterase / Q000097:blood / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007036:Hypothermia, Induced; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D000077590:Mivacurium; D003473:Neuromuscular Nondepolarizing Agents / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002091:Butyrylcholinesterase; D005459:Fluorides