title: Wnt6 marks sites of epithelial transformations in the chick embryo.
abstract: In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm, we have isolated a novel chick Wnt gene, chick Wnt6. This gene encodes the first pan-epidermal Wnt signalling molecule. Further sites of expression are the boundary of the early neural plate and surface ectoderm, the roof of mesencephalon, pretectum and dorsal thalamus, the differentiating heart, and the otic vesicle. The precise sites of Wnt6 expression coincide with crucial changes in tissue architecture, namely epithelial remodelling and epithelial-mesenchymal transformation (EMT). Moreover, the expression of Wnt6 is closely associated with areas of Bmp signalling.
authors.affiliation: MRC Centre for Developmental Neurobiology, King's College London, 4th Floor New Hunt's House, Guy's Campus, London SE1 1UL, UK.
authors.forename: Frank R
authors.initials: FR
authors.lastname: Schubert
authors.forename: Roy C
authors.initials: RC
authors.lastname: Mootoosamy
authors.forename: Esther H
authors.initials: EH
authors.lastname: Walters
authors.forename: Anthony
authors.initials: A
authors.lastname: Graham
authors.forename: Loretta
authors.initials: L
authors.lastname: Tumiotto
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Münsterberg
authors.forename: Andrew
authors.initials: A
authors.lastname: Lumsden
authors.forename: Susanne
authors.initials: S
authors.lastname: Dietrich
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002490:Central Nervous System / Q000196:embryology; D002642:Chick Embryo; D003001:Cloning, Molecular; D007758:Ear, Inner / Q000196:embryology; D004475:Ectoderm / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D015870:Gene Expression; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D010802:Phylogeny; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D011518:Proto-Oncogene Proteins; D012313:RNA