Yoghurt biotherapy: contraindicated in immunosuppressed patients?
A fatal case of Lactobacillus rhamnosus septicaemia after prolonged oral vancomycin for recalcitrant Clostridium difficile infection is reported. The patient was immunosuppressed with cyclophosphamide and steroids for Sjögren's syndrome. The administration of Lactobacillus spp as "biotherapy" may be hazardous in such circumstances.
MacGregor
Gordon
G
Department of Respiratory Medicine, 2nd Floor OPD, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, Scotland, UK.
Smith
A J
AJ
Thakker
B
B
Kinsella
J
J
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001691:Biological Therapy; D000075202:Contraindications; D003520:Cyclophosphamide / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007778:Lactobacillus; D009894:Opportunistic Infections / Q000382:microbiology* / Q000401:mortality; D018805:Sepsis / Q000382:microbiology* / Q000401:mortality; D012859:Sjogren's Syndrome / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D014640:Vancomycin / Q000627:therapeutic use; D015014:Yogurt / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D014640:Vancomycin; D003520:Cyclophosphamide; D005438:Fludrocortisone