Arsenic carcinogenicity: relevance of c-Src activation.
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.
Simeonova
Petia P
PP
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA. phs9@cdc.gov
Luster
Michael I
MI
D001151:Arsenic / Q000494:pharmacology* / Q000633:toxicity*; D002273:Carcinogens / Q000494:pharmacology* / Q000633:toxicity*; D066246:ErbB Receptors / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D016391:Genes, src / Q000235:genetics*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D015688:Oncogene Protein pp60(v-src) / Q000235:genetics* / Q000378:metabolism*
D002273:Carcinogens; D066246:ErbB Receptors; D015688:Oncogene Protein pp60(v-src); D020928:Mitogen-Activated Protein Kinases; D001151:Arsenic