Progress of Cell Adhesion Mediated Signal-Focal Adhesion Kinase.
Focal adhesion kinase (FAK) is an important component in integrin mediated cell adhesion. It has tyrosine kinase activity and is capable of self-phosphorylation. New members of FAK family have been found recently with similar function of FAK. FAK can suppress cell apoptosis and also is a substrate of caspase. As a signaling molecule, FAK takes crosstalk with other signal transduction pathways within cell. It regulates various cell effects directly.
Zha
Xi-Liang
XL
Department of Biochemistry, Ministry of Health Key Laboratory of Glycoconjugate, Shanghai Medical University, Shanghai 200032, China. xlzha@shmu.edu.cn