title: Primary cutaneous lymphoblastic lymphoma presenting in an 8-week old infant.
abstract: BACKGROUND
  We report a case of primary cutaneous lymphoblastic lymphoma (LBL) presenting in an 8-week-old infant.
  
  
  METHODS
  Histopathology and flow cytometric analysis confirmed the diagnosis of a lymphoblastic lymphoma. The cells expressed CD19, CD20, CD34 and surface immunoglobulin (sIg).
  
  
  RESULTS
  The cells were negative for TdT and CD99. This unusual immunophenotype has been described as "transitional pre-B-cell", in that the cells express both immature markers (CD34) and mature markers (sIg).
  
  
  CONCLUSIONS
  To our knowledge, only five other cases of sIg positive precursor B-cell LBL have been reported in the literature. This may represent the youngest reported case of primary cutaneous LBL, occurring at 8weeks of age.
authors.affiliation: Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Trupiano
authors.forename: Karen
authors.initials: K
authors.lastname: Bringelsen
authors.forename: Eric D
authors.initials: ED
authors.lastname: Hsi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D008727:Methotrexate