5-Fluorouracil encapsulated alginate beads for the treatment of breast cancer.
Alginate beads containing 5-fluorouracil (5-FU) were prepared by the gelation of alginate with calcium cations. Alginate beads loaded with 5-FU were prepared at 1.0 and 2.0% (w/v) polymers. The effect of polymer concentration and the drug loading (1.0, 5.0 and 10%) on the release profile of 5-FU was investigated. As the drug load increased, larger beads were obtained in which the resultant beads contained higher 5-FU content. The encapsulation efficiencies obtained for 5-FU loads of 1.0, 5.0 and 10% (w/v) were 3.5, 7.4 and 10%, respectively. Scanning electron microscopy (SEM) and particle size analysis revealed differences between the formulations as to their appearance and size distribution. The amount of 5-FU released from the alginate beads increased with decreasing alginate concentrations.
Arica
B
B
Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Sihhiye-Ankara, Turkey.
Caliş
S
S
Kaş
H
H
Sargon
M
M
Hincal
A
A
D000464:Alginates; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004339:Drug Compounding; D005079:Excipients; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D012995:Solubility
D000464:Alginates; D000964:Antimetabolites, Antineoplastic; D005079:Excipients; D005472:Fluorouracil