Fibroblast growth factors and their receptors in oligodendrocyte development: implications for demyelination and remyelination.
Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses. This review focuses on the fibroblast growth factors signaling in oligodendrocyte development, function and discusses implications for demyelination/remyelination.
Bansal
Rashmi
R
Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030-3401, USA. bansal@neuron.uchc.edu
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation; D019070:Cell Lineage; D003711:Demyelinating Diseases / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000145:classification / Q000235:genetics / Q000502:physiology*; D009185:Myelin Proteins / Q000096:biosynthesis / Q000235:genetics; D009186:Myelin Sheath / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009836:Oligodendroglia / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects
D009185:Myelin Proteins; D009419:Nerve Tissue Proteins; D017468:Receptors, Fibroblast Growth Factor; D016222:Fibroblast Growth Factor 2; D005346:Fibroblast Growth Factors