Synthesis and biological evaluation of novel D-2'-azido-2',3'-dideoxyarabinofuranosyl-4'-thiopyrimidines and purines.
Novel D-2'-azido-2',3'-dideoxyarabinofuranosyl-4'-thiopyrimidines and purines have been synthesized, starting from L-xylose via azidation at the 2'-position as a key step. Most of the final nucleosides exhibited toxicity-dependent anti-HIV-1 activity, among which D-alpha-adenine analogue was found to be the most cytotoxic.
Kim
Hea Ok
HO
Division of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Republic of Korea.
Park
Yong Hee
YH
Moon
Hyung Ryong
HR
Jeong
Lak Shin
LS
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001386:Azides; D002455:Cell Division / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D011687:Purines; D011743:Pyrimidines; D013329:Structure-Activity Relationship; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
D019380:Anti-HIV Agents; D001386:Azides; D011687:Purines; D011743:Pyrimidines; D013872:Thionucleosides