title: Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge.
abstract: The Drosophila gene wingless encodes a secreted signalling molecule that is required for many patterning events in both embryonic and postembryonic development. In the wing wingless is expressed in a complex and dynamic pattern that is controlled by several different mechanisms. These involve the Hedgehog and Notch pathways and the nuclear proteins Pannier and U-shaped. In this report, we analyse the mechanisms that drive wingless expression in the wing hinge. We present evidence that wingless is initially activated by a secreted signal that requires the genes vestigial, rotund and nubbin. Later in development, wingless expression in the wing hinge is maintained by a different mechanism, which involves an autoregulatory loop and requires the genes homothorax and rotund. We discuss the role of wingless in patterning the wing hinge.
authors.affiliation: Centro de Biología Molecular-Severo Ochoa/C.S.I.C., Facultad de Ciencias-CV, Universidad Autónoma-Cantoblanco, 28049 Madrid, Spain.
authors.forename: David del Alamo
authors.initials: Ddel A
authors.lastname: Rodríguez Dd
authors.forename: Javier
authors.initials: J
authors.lastname: Terriente
authors.forename: Máximo I
authors.initials: MI
authors.lastname: Galindo
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Couso
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Díaz-Benjumea
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D007814:Larva; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D050809:POU Domain Factors; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014921:Wings, Animal / Q000196:embryology / Q000378:metabolism*; D051155:Wnt1 Protein
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D050809:POU Domain Factors; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D051155:Wnt1 Protein; C108704:hth protein, Drosophila; C104121:nub protein, Drosophila; C450829:rn protein, Drosophila; C095064:vg protein, Drosophila; C074622:wg protein, Drosophila