title: Differential and Tissue-specific Expression of Mitochondrial Elongation Factor Tu and Ts during Development.
abstract: The mitochondrial elongation factors Tu and Ts (EF-Tu(mt) and EF-Ts(mt)) are nuclear gene-encoded mitochondrial proteins and play important roles in growth and development. We prepared antibodies against EF-Tu(mt) and EF-Ts(mt) using purified recombinant EF-Tu(mt) and EF-Ts(mt). Western analysis indicates EF-Tu(mt) and EF-Ts(mt) are expressed differently in various tissues. Their expression in heart and liver increased during development and reached plateau at maturation. Expression of EF-Tu(mt) and EF-Ts(mt) exhi-bited similar tissue-specificity and changed synchronically during development. These results suggest that expression levels of EF-Tu(mt) and EF-Ts(mt) may be regulated by a similar mechanism related to the metabolic state of the cells.
authors.affiliation: State Key Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai 200032, China. lanma@shmu.edu.cn
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Xu-Lei
authors.initials: XL
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Lan
authors.initials: L
authors.lastname: Ma