Metabolic characteristics of women who developed ovarian hyperstimulation syndrome.
BACKGROUND
The aim of this study was to investigate whether a higher incidence of hyperinsulinism is found in women who have suffered from ovarian hyperstimulation syndrome (OHSS) as compared with other IVF patients. Additionally, we also assessed whether any abnormalities in the haemostatic system were more frequent in women with a past history of OHSS.


METHODS
A pilot study was carried out involving OHSS patients and matched IVF patients. Homeostasis model assessment (HOMA) of insulin sensitivity was calculated. The main outcome measures were: insulin sensitivity, coagulation anomalies, factor V Leiden mutations, methylene tetrahydrofolate reductase (MTHFR) polymorphism and prothrombin gene mutation, protein C and protein S deficiency.


RESULTS
No increased incidence in hyperinsulism nor in abnormalities of the haemostatic system were observed.


CONCLUSIONS
This pilot study does not provide evidence for an increased prevalence of hyperinsulinism among women who have developed OHSS in the past.
Delvigne
Annick
A
Departments of Obstetrics and Gynaecology, IVF and Haematology, St Pierre University Hospital, Free University of Brussels, Rue Haute, 322, 1000 Brussels, Belgium. annickdelvigne@swing.be
Kostyla
Karol
K
De Leener
Anne
A
Lejeune
Bernard
B
Cantiniaux
Brigitte
B
Bergmann
Pierre
P
Rozenberg
Serge
S
D000328:Adult; D005165:Factor V / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D012720:Severity of Illness Index; D013927:Thrombosis / Q000209:etiology / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)