title: Memory CD8(+) T cells undergo peripheral tolerance.
abstract: Memory T cells differ from naive T cells in that they respond more rapidly and in greater numbers. In addition, memory T cells are generally believed to be less susceptible to tolerance induction than naive T cells. In this study, we show that this is not the case. Using two different methods of tolerance induction, peptide-induced tolerance and crosstolerance, we present evidence that memory CD8(+) T cells are as susceptible to tolerance as naive cells. These results have a direct impact on manipulating T cell responses to self-antigens in order to improve immunotherapy of cancer and autoimmune diseases.
authors.affiliation: Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Huub T C
authors.initials: HT
authors.lastname: Kreuwel
authors.forename: Sandra
authors.initials: S
authors.lastname: Aung
authors.forename: Cheryl
authors.initials: C
authors.lastname: Silao
authors.forename: Linda A
authors.initials: LA
authors.lastname: Sherman
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001324:Autoantigens / Q000276:immunology; D002460:Cell Line; D002999:Clone Cells; D003920:Diabetes Mellitus / Q000276:immunology; D019672:Genes, T-Cell Receptor; D006388:Hemagglutinins / Q000276:immunology / Q000378:metabolism; D007108:Immune Tolerance; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010179:Pancreas / Q000276:immunology; D010455:Peptides / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D001324:Autoantigens; D006388:Hemagglutinins; D010455:Peptides