seco-Adianane-type triterpenoids from Dorstenia brasiliensis (Moraceae).
Two seco-adianane-type triterpenoids, dorstenic acid A and B, were isolated, along with a known isopimarane-type diterpenoid and six coumarins, from the roots of Dorstenia brasiliensis. Their structures were elucidated on the basis of their spectral data. The two triterpenoids showed moderate cytotoxicity against leukemia cells (L-1210 and HL-60).
Uchiyama
Taketo
T
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
Hara
Shoji
S
Makino
Mitsuko
M
Fujimoto
Yasuo
Y
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C470763:dorstenic acid A; C470762:dorstenic acid B