title: Eosinophilic lung disease under chemotherapy with oxaliplatin for colorectal cancer.
abstract: A 60-year-old woman with a history of unresectable colon adenocarcinoma was treated by chemotherapy with a combination of oxaliplatin with leucovorin and fluorouracil. Progressive dyspnea and bilateral pulmonary interstitial infiltrates developed. Bronchoscopy with bronchoalveolar lavage confirmed pulmonary eosinophilia. Clinical and radiologic aspects of eosinophilic lung disease cleared after cessation of this combination of chemotherapy and did not recur after reintroduction of leucovorin/fluorouracil alone, suggesting that oxaliplatin was the causative agent. Care was taken to rule out other possible causes for eosinophilic pneumonia.
authors.affiliation: Department of Pulmonary Medicine, Hôpital Saint-Antoine, Paris, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Gagnadoux
authors.forename: Cecile
authors.initials: C
authors.lastname: Roiron
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Carrie
authors.forename: Laurence
authors.initials: L
authors.lastname: Monnier-Cholley
authors.forename: Bernard
authors.initials: B
authors.lastname: Lebeau
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil