Synthesis of cholesterol-carborane conjugate for targeted drug delivery.
The cholesterol-carborane conjugate has been designed and synthesized to selectively deliver boron to tumor cells by means of reconstituted low-density lipoprotein. The chemical stability and cytotoxicity of the new compound have been examined. Several methods have been evaluated for incorporation of the compound into LDL.
Ji
Bingqing
B
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, GA 30602, Athens, USA
Peacock
Gina
G
Lu
D Robert
DR
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001896:Boron Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D016754:Boron Neutron Capture Therapy / Q000379:methods; D016923:Cell Death / Q000187:drug effects; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology*; D016503:Drug Delivery Systems; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008077:Lipoproteins, LDL; D008081:Liposomes; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001896:Boron Compounds; D008077:Lipoproteins, LDL; D008081:Liposomes; D002784:Cholesterol