title: [Construction of an artificial digenic network with epigenetic properties].
abstract: A model of the simplest epigene was constructed to have two alternative states, which proved to be stable and transmittable through Escherichia coli cell generations. A switch from one to another state was induced by thermal and chemical external signals. The results gave further insight into the dynamic mechanism of preservation, coding, and transmission of the genetic information.
authors.affiliation: Institute of Biology, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054 Russia.
authors.forename: T S
authors.initials: TS
authors.lastname: Tropynina
authors.forename: O V
authors.initials: OV
authors.lastname: Golubev
authors.forename: E E
authors.initials: EE
authors.lastname: Stupak
authors.forename: R N
authors.initials: RN
authors.lastname: Churaev
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D005818:Genetic Engineering / Q000379:methods*; D007544:Isopropyl Thiogalactoside / Q000494:pharmacology; D056968:Lac Repressors; D010957:Plasmids / Q000235:genetics; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D013696:Temperature; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; D001616:beta-Galactosidase / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D056968:Lac Repressors; C539064:LacI protein, E coli; D012097:Repressor Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C016649:phage repressor proteins; D007544:Isopropyl Thiogalactoside; D001616:beta-Galactosidase