title: Computerized lesion detection on breast ultrasound.
abstract: We investigated the use of a radial gradient index (RGI) filtering technique to automatically detect lesions on breast ultrasound. After initial RGI filtering, a sensitivity of 87% at 0.76 false-positive detections per image was obtained on a database of 400 patients (757 images). Next, lesion candidates were segmented from the background by maximizing an average radial gradient (ARD) index for regions grown from the detected points. At an overlap of 0.4 with a radiologist lesion outline, 75% of the lesions were correctly detected. Subsequently, round robin analysis was used to assess the quality of the classification of lesion candidates into actual lesions and false-positives by a Bayesian neural network. The round robin analysis yielded an Az value of 0.84, and an overall performance by case of 94% sensitivity at 0.48 false-positives per image. Use of computerized analysis of breast sonograms may ultimately facilitate the use of sonography in breast cancer screening programs.
authors.forename: Karen
authors.initials: K
authors.lastname: Drukker
authors.forename: Maryellen L
authors.initials: ML
authors.lastname: Giger
authors.forename: Karla
authors.initials: K
authors.lastname: Horsch
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Kupinski
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Vyborny
authors.forename: Ellen B
authors.initials: EB
authors.lastname: Mendelson
mesh_terms: D001499:Bayes Theorem; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D019992:Databases as Topic; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008403:Mass Screening; D015233:Models, Statistical; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012984:Software; D014463:Ultrasonography / Q000379:methods*