title: Cytokine polymorphisms in silicosis and other pneumoconioses.
abstract: Silicosis and coal workers' pneumoconiosis are complex multifactorial lung diseases whose etiopathogenesis are not well defined. It is generally accepted that fibrotic lung disorders are mediated by macrophage-derived cytokines and growth factors. There is evidence showing a crucial role for tumor necrosis factor-a (TNF-alpha) and interleukin-1 (IL-1) in inflammation caused by silica dust and in the transition from simple to progressive massive fibrosis. In this review we discuss genetic polymorphisms responsible for regulating the production of these proinflammatory cytokines and their role in modifying silicosis severity.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Toxicology, Turkey.
authors.forename: Berran
authors.initials: B
authors.lastname: Yucesoy
authors.forename: Val
authors.initials: V
authors.lastname: Vallyathan
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Landsittel
authors.forename: Petia
authors.initials: P
authors.lastname: Simeonova
authors.forename: Michael I
authors.initials: MI
authors.lastname: Luster
mesh_terms: D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011009:Pneumoconiosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012829:Silicosis / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha