title: [Diagnostic utility of Osler's nodules in infectious endocarditis among parenteral drug users].
abstract: BACKGROUND
  The objective of study is to describe of clinic, microbiological and histological data of five cases of infective endocarditis (IE) with Osler's nodes in intravenous drug users. PATIENTS Y METHODS: Prospectively, 43 cases of IE in intravenous drugs users was revised. In 4 patients, a aspirate puncture of Osler's node was performed and in one patient a biopsy of Osler's node was done with Gram's stain and culture of specimen.
  
  
  RESULTS
  From 43 episodes of IE, 33 were right-side IE, 9 left-side y 1 right and left side. No patients with right-side IE presented Osler's nodes, however five of 10 (50%) patients with left-side endocarditis. In all of cases gram positive cocci were observed in Gram's strain and Staphylococcus aureus growth on culture of lesion with the same antibiotype than isolated from blood culture. One case a cutaneous biopsy was performed, and inflammatory infiltrate with necrosis was found.
  
  
  CONCLUSIONS
  The Gram's strain and culture of specimen aspirated from Osler's nodes were of high utility in the diagnosis of IE in intravenous drugs users. The presence of Osler's nodes in a patient with infective endocarditis must be suggest that the location in left-side. These data suggest that Osler's nodes in infective endocarditis by S. aureus in intravenous drugs users was originated by microvascular septic emboli.
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario J.M. Morales Meseguer, Murcia.
authors.forename: F J
authors.initials: FJ
authors.lastname: Espinosa Parra
authors.forename: J M
authors.initials: JM
authors.lastname: Ramos Rincón
authors.forename: F
authors.initials: F
authors.lastname: Herrero Huerta
authors.forename: L
authors.initials: L
authors.lastname: Pretel Serrano
authors.forename: A A
authors.initials: AA
authors.lastname: Lorenzo
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D001706:Biopsy; D004617:Embolism / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000209:etiology; D004890:Erythema / Q000209:etiology* / Q000382:microbiology; D005260:Female; D005385:Fingers / Q000098:blood supply / Q000382:microbiology / Q000473:pathology*; D005840:Gentian Violet; D006801:Humans; D008297:Male; D010619:Phenazines; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000150:complications / Q000175:diagnosis*; D013207:Staphylococcal Skin Infections / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D015819:Substance Abuse, Intravenous / Q000150:complications*; D014034:Toes / Q000098:blood supply / Q000382:microbiology / Q000473:pathology*
chemical_list: C035863:Gram's stain; D010619:Phenazines; D005840:Gentian Violet