title: [Hydroxy(aryl)methylene]diphosphonic acids, a class of drugs in bone pathology treatments, crystallize as head-to-head dimers.
abstract: Two [hydroxy(aryl)methylene]diphosphonic acids have been crystallized as dimers. The first compound, [hydroxy(phenyl)methylene]diphosphonic acid monohydrate, C(7)H(10)O(7)P(2).H(2)O, crystallizes in the non-centrosymmetric space group P2(1), with the two enantiomers related by a non-crystallographic centre of inversion, while the second compound, [hydroxy(4-nitrophenyl)methylene]diphosphonic acid tetrahydrofuran disolvate, C(7)H(9)NO(9)P(2).2C(4)H(8)O, crystallizes in the centrosymmetric space group P2(1)/c and uses the centre of symmetry to form the same dimer.
authors.affiliation: Chimie Structurale et Spectroscopie Biomoléculaire, UMR 7033-CNRS, 74 rue M. Cachin, 93017 Bobigny Cedex, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Lecouvey
authors.forename: Carole
authors.initials: C
authors.lastname: Barbey
authors.forename: Alda
authors.initials: A
authors.lastname: Navaza
authors.forename: Alain
authors.initials: A
authors.lastname: Neuman
authors.forename: Thierry
authors.initials: T
authors.lastname: Prangé
mesh_terms: D001847:Bone Diseases / Q000188:drug therapy*; D018360:Crystallography, X-Ray; D004164:Diphosphonates / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular
chemical_list: D004164:Diphosphonates