Natural products as trypanocidal, antileishmanial and antimalarial drugs.
Parasitic diseases caused by protozoa as Leishmania, Trypanosome or Plasmodium are responsible for more than three millions deaths annually throughout the developing countries. This review covers recent studies on plant-secondary metabolites isolated from medicinal plants and that have demonstrated moderate to high activity in in vitro and in vivo bioassays against these protozoa. The biological activity of the last promising antiparasitic leads are described.
Fournet
Alain
A
Laboratoire de Pharmacognosie, IRD (Institut de recherche pour le développement), Faculté de Pharmacie, rue Jean-Baptiste Clément, Chacric;tenay-Malabry, 92296, France. ALAIN.FOURNET@wanadoo.fr
Muñoz
Victoria
V
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy / Q000469:parasitology; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014352:Trypanosomiasis / Q000188:drug therapy / Q000469:parasitology
D000962:Antimalarials; D000981:Antiprotozoal Agents; D001688:Biological Products; D014344:Trypanocidal Agents