Genes and orthopedics: from gene to clinic and vice versa.
Recent advances in molecular biology have greatly helped in understanding the mechanisms involved in normal skeletal morphogenesis. Multiple genes involved in normal skeletal development have been identified, but several others still await discovery. Mutations in these genes are often responsible for the congenital skeletal malformations that we see in the orthopedic clinics. In this overview we would like to emphasize the importance of the interaction between orthopaedic surgeons, molecular biologists and geneticists.
Debeer
Ph
P
Department of Orthopedics, University Hospital Pellenberg, Weligerveld 1, B-3212 Lubbeek, Pellenberg, Belgium.
De Smet
L
L
Van De Ven
W J M
WJ
Fabry
G
G
Fryns
J P
JP
D001848:Bone Diseases, Developmental / Q000175:diagnosis / Q000235:genetics*; D005817:Genetic Counseling; D005820:Genetic Testing; D006801:Humans; D008967:Molecular Biology; D009139:Musculoskeletal Abnormalities / Q000175:diagnosis / Q000235:genetics*; D009985:Orthopedics