Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Our study aimed at examining the possible anti-inflammatory and antinociceptive effects of dantrolene sodium in rats and mice. The anti-inflammatory effect of dantrolene sodium (2.5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests. Analgesic effects of dantrolene sodium were evaluated and compared with metamizol (200 mg kg (-1)) in acetic acid-induced writhing and formalin-induced paw licking tests. It was found that dantrolene sodium significantly diminished the nociceptive response in mice, showing at the same time considerable anti-inflammatory properties in rats.
Büyükokuroğlu
Mehmet Emin
ME
Medical Faculty, Department of Pharmacology, Atatürk University, TR-25240 Erzurum, Turkey. memin@atauni.edu.tr
D019342:Acetic Acid; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan; D003620:Dantrolene / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use; D004177:Dipyrone / Q000627:therapeutic use; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005557:Formaldehyde; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D006632:Histamine; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D005557:Formaldehyde; D004177:Dipyrone; D006632:Histamine; D002351:Carrageenan; D003620:Dantrolene; D019342:Acetic Acid