Effects of energostim on the sympathoadrenal system and contents of pyridine nucleotides during acute myocardial infarction.
The contents of myofibrillar creatine phosphokinase and cytochrome c, the key enzyme of the mitochondrial respiratory chain, increased, while the content of nicotinamide coenzymes and redox potential (NAD/NADH ratio) sharply decreased over the first 6 h of acute myocardial infarction. The contents of norepinephrine and epinephrine increased by 51 and 49%, respectively, 6 h after onset of acute myocardial infarction. By contrast, dopamine concentration decreased by 116% during this period. The increase in the content of cytochrome c directly correlated with the concentration of myofibrillar creatine phosphokinase and Peel index. No correlations were found between norepinephrine/epinephrine and dopamine/(norepinephrine+epinephrine) ratios. The antihypoxant with direct action energostim normalized the content of cytochrome c, increased NAD and dopamine concentrations and NAD/NADH ratio, and decreased the content of norepinephrine and epinephrine to the baseline level in patients with acute myocardial infarction. These results indicate that energostim possesses not only antihypoxic and antioxidant activities, but also pronounced antisympathomimetic properties.
Sukoyan
G V
GV
Republican Research Center for Medical Biophysics and Implementation of New Biomedical Technologies, Tbilsi.
Chikobava
E A
EA
Tatulashvili
D R
DR
Andriadze
N A
NA
Karsanov
N V
NV
D000311:Adrenal Glands / Q000378:metabolism*; D000975:Antioxidants / Q000494:pharmacology*; D002395:Catecholamines / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D003574:Cytochrome c Group / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D002395:Catecholamines; D003574:Cytochrome c Group; D011725:Pyridines; D003402:Creatine Kinase; D004837:Epinephrine