UV spectra of guanine methyl and glycosyl derivatives and their transformations induced by interactions with amino acids via carboxylic group in dimethylsulfoxide.
UV absorption spectra of guanine derivatives m9Gua, m(2)2,9Gua, m1Gua, m(2)1,7Gua, m3Gua, G, dG, m1G, m2G, m7G, as well as guanine analogue isoGua were studied in anhydrous dimethylsulfoxide (DMSO). Changes in UV absorption spectra of guanine derivatives in the presence of amino acid derivatives with neutral carboxylic group (ac-Asp, ac-Glu, ac-Gly, ac-Asp-OMe) or deprotonated carboxylic group (NaAc, f-Gly-ONa) were investigated and interpreted. The m1Gua and m7Gua derivatives were shown to exist as the N9H tautomers in anhydrous DMSO. The majority of examined guanine derivatives were determined to interact with deprotonated carboxylic group only, except of m7G, isoGua and m3Gua, which are able to form complexes with neutral carboxylic group as well.
Stepanyugin
A V
AV
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine.
Potyahaylo
A L
AL
Kolomiets
I M
IM
Samijlenko
S P
SP
Hovorun
D M
DM
D000596:Amino Acids / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D006031:Glycosylation; D006147:Guanine / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D002264:Carboxylic Acids; D006147:Guanine; D004121:Dimethyl Sulfoxide