Preconditioning hypobaric hypoxia prevents anoxia-induced inhibition of generation of focal potentials in slices of olfactory cortex from rat brain.
We studied the effect of in vivo exposure to hypobaric hypoxia of different depth on the resistance of neurons in brain slices to 10-min anoxia in vitro. Severe hypoxia simulating ascent to 11,000 m above sea level potentiated the adverse effect of 10-min anoxia and caused profound suppression of synaptic transmission. Moderate preconditioning hypoxia simulating ascent to 5000 m above sea level produced a long-lasting protective effect on synaptic activity.
Romanovskii
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I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. anoxia@pavlov.infran.ru
Tyul'kova
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EI
Samoilov
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MO
D000531:Altitude; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D000860:Hypoxia; D019194:Ischemic Preconditioning; D008297:Male; D009474:Neurons / Q000378:metabolism; D009833:Olfactory Pathways / Q000473:pathology*; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors