The role of beta-amyloid in Alzheimer's disease.
The current understanding of the role of amyloid in AD has been established by a remarkable congruence of multiple disciplines: neuropathology, biochemistry, molecular biology, and epidemiologic genetics. Although the precise etiology of AD still remains poorly understood, the identification of the key biochemical players in the A beta generation (APP, PS-1 and -2, and BACE), and the development of transgenic models exhibiting progressive disease pathology, provide a strong framework on which to build a better understanding of the molecular events that lead to progressive neurodegeneration in AD.
Sinha
Sukanto
S
Elan Biopharmaceuticals, 800 Gateway Boulevard, South San Francisco, CA 94080, USA. sukanto.sinha@elan.com
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D017772:Amyloid Neuropathies / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics; D006801:Humans; D008954:Models, Biological
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor