Decreased levels of coenzyme Q(10) in patients with bronchial asthma.
BACKGROUND
The contribution of free oxygen radicals in the pathogenesis of bronchial asthma is generally accepted. The modulation of antioxidative defence by supplementation with antioxidants represents additive therapy in complex management of disease. The aim of the study was to assess the levels of coenzyme Q10, alpha-tocopherol, and beta-carotene both in plasma and whole blood, and malondialdehyde (MDA) and eosinophil cationic protein (ECP) in plasma of asthmatics (As).


METHODS
Fifty-six As (15 males and 41 females) aged from 19 to 72 years (mean age 46 years) suffering from allergic asthma were enrolled into the study. The control group comprised 25 healthy volunteers (16 males, 9 females) aged 25-50 years.


RESULTS
The concentrations of CoQ10 decreased significantly both in plasma and whole blood, compared with healthy volunteers (0.34 +/- 0.15 micromol/l vs. 0.52 +/- 0.15 micromol/l, 0.33 +/- 0.14 micromol/l vs. 0.50 +/- 0.13 micromol/l, P < 0.001, P< 0.001, respectively). The levels of alpha-tocopherol were decreased both in plasma and whole blood in comparison with controls [24.10 micromol/l (19.8; 30.5), vs. 33.20 micromol/l (28.25; 38.05), 17.22 +/- 6.45 micromol/l vs. 21.58 +/- 7.92 micromol/l, P= 0.006, P = 0.01, respectively]. The levels of MDA were elevated over the reference range in both groups (reference range < 4.5 micromol/l). No changes were seen in beta-carotene concentrations. Positive correlation was found between whole blood CoQ10 and alpha-tocopherol concentrations.


CONCLUSIONS
Results of the study suggest a possible contribution of suboptimal concentrations of CoQ10 on antioxidative dysbalance in As and provide a rationale for its supplementation.
Gazdík
F
F
Department of Clinical Immunology, Institute of Preventive and Clinical Medicine, Bratislava.
Gvozdjáková
A
A
Nádvorníková
R
R
Repická
L
L
Jahnová
E
E
Kucharská
J
J
Piják
M R
MR
Gazdíková
K
K
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D001249:Asthma / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D003067:Coenzymes; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D012260:Ribonucleases; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood*; D024502:alpha-Tocopherol / Q000097:blood; D019207:beta Carotene / Q000097:blood
D000975:Antioxidants; D001798:Blood Proteins; D003067:Coenzymes; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D019207:beta Carotene; D014451:Ubiquinone; D008315:Malondialdehyde; D012260:Ribonucleases; C024989:coenzyme Q10; D024502:alpha-Tocopherol