IL-10 in myeloma cells.
In addition to interleukin (IL)-6, IL-10 is considered as one of the most important cytokines regulating the proliferation and cellular characteristics of myeloma cells. It is still unclear from the clinical data how serum IL-10 levels of various stages of myeloma, are related to clinical manifestations of this disease. Several studies have reported that IL-10 affects myeloma cells by stimulating secondary signals for cell proliferation through oncostatin M (OSM) and IL-11. In experiments using human myeloma cell lines established at our laboratory, IL-10 seemed to be expressed in half of myelomas simultaneously with OSM, and to be correlated with c-maf, a transcription factor, which has been known to be overexpressed in myelomas with t(14;16)(q32;q23). In addition, IL-10 abolishes all trans retinoic acid (ATRA)-induced growth inhibition of myeloma cells. The expression and production of IL-10 in myeloma patients may be important for sub-categorization and the establishment of a case-oriented therapy.
Otsuki
Takemi
T
Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama, Japan. takemi@med.kawasaki-m.ac.jp
Yata
Kenichiro
K
Sakaguchi
Haruko
H
Uno
Masako
M
Fujii
Tomohiro
T
Wada
Hideho
H
Sugihara
Takashi
T
Ueki
Ayako
A
D002455:Cell Division; D016207:Cytokines / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics / Q000502:physiology*; D009101:Multiple Myeloma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D014212:Tretinoin / Q000627:therapeutic use
D016207:Cytokines; D016753:Interleukin-10; D014212:Tretinoin