title: Gross and microscopic findings in patients submitted to nonablative full-face resurfacing using intense pulsed light: a preliminary study.
abstract: BACKGROUND
  Intense pulsed light (IPL) is a noncoherent, nonlaser, filtered flashlamp emitting a broadband visible light that has been shown to be effective in photoepilation, as well as in a number of vascular and pigmented lesions of the skin. Their efficacy has also been reported recently in the treatment of photodamaged facial skin. In the last condition, however, there are few studies showing the clinical and microscopic changes produced by IPL.
  
  
  OBJECTIVE
  To assess the gross and microscopic changes that occur in photodamaged skin submitted to nonablative full-face resurfacing (NAFFR) using IPL.
  
  
  METHODS
  Five women were submitted to five NAFFR sessions using IPL, one every 2 weeks. Skin biopsies and photographs were taken on all of the patients before the first procedure and after the last one, as well as weekly clinical assessment. Data concerning skin features (wrinkles, oiliness, thickness, dilated pores, and general appearance) were all assessed. Microscopic improvement of the aging features in the epidermis and dermis were all assessed. For the statistical analysis a t test for small samples was used.
  
  
  RESULTS
  All the patients showed clinical and microscopic improvement in every one of the parameters assessed. The t test for small samples showed a statistically significant difference (P < 0.01) in epidermal thickness.
  
  
  CONCLUSIONS
  Facial photodamage was clinically and microscopically improved using IPL. Use of IPL as a rejuvenating method seems to be promising, with minimal side effects, a wide safety margin, and minimal downtime.
authors.affiliation: Center for Dermatology and Cosmetic Surgery, San Salvador, El Salvador. enrimar@vip.telesal.net
authors.forename: Enrique
authors.initials: E
authors.lastname: Hernández-Pérez
authors.forename: Erick Valencia
authors.initials: EV
authors.lastname: Ibiett
mesh_terms: D000328:Adult; D005145:Face; D005260:Female; D006801:Humans; D008875:Middle Aged; D010789:Phototherapy; D015361:Rhytidoplasty / Q000379:methods*; D012867:Skin / Q000473:pathology*; D015595:Skin Aging / Q000528:radiation effects*; D016896:Treatment Outcome