Vitamin E and neurodegenerative disorders associated with oxidative stress.
Several neurodegenerative disorders are associated with oxidative stress that is manifested by lipid peroxidation, protein oxidation and other markers. Included in these disorders in which oxidative stress is thought to play an important role in their pathogenesis are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof.
Butterfield
D Allan
DA
Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington 40506, USA. dabcns@uky.edu
Castegna
Alessandra
A
Drake
Jennifer
J
Scapagnini
Giovanni
G
Calabrese
Vittorio
V
D000544:Alzheimer Disease; D000690:Amyotrophic Lateral Sclerosis; D001682:Biological Availability; D020820:Dyskinesias; D006801:Humans; D006816:Huntington Disease; D007408:Intestinal Absorption; D015227:Lipid Peroxidation; D009103:Multiple Sclerosis; D019636:Neurodegenerative Diseases; D018384:Oxidative Stress; D010300:Parkinson Disease; D014810:Vitamin E / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000502:physiology
D014810:Vitamin E