title: From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction.
authors.affiliation: Ludwig Institute for Cancer Research, SE-751 24 Uppsala, Sweden. Aris.Moustakas@licr.uu.se
authors.forename: Aristidis
authors.initials: A
authors.lastname: Moustakas
authors.forename: Carl-Henrik
authors.initials: CH
authors.lastname: Heldin
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D004705:Endocytosis; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D046911:Macromolecular Substances; D010766:Phosphorylation; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D017434:Protein Structure, Tertiary; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta; D012697:Serine Endopeptidases; D015398:Signal Transduction / Q000502:physiology*; D051900:Smad3 Protein; D051901:Smad4 Protein; D013329:Structure-Activity Relationship; D015534:Trans-Activators / Q000737:chemistry / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D046911:Macromolecular Substances; D018125:Receptors, Transforming Growth Factor beta; C497790:SMAD3 protein, human; C497796:SMAD4 protein, human; D051900:Smad3 Protein; D051901:Smad4 Protein; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D020794:Receptor Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C116420:ZFYVE16 protein, human; D012697:Serine Endopeptidases