Antiseptic compounds still active against bacterial strains isolated from surgical wound infections despite increasing antibiotic resistance.
The in vitro activities of povidone iodine, potassium peroxymonosulfate, and dimethyldidecylammonium chloride were investigated against 379 nosocomial isolates of Staphylococcus aureus and Pseudomonas aeruginosa responsible for surgical wound infections in patients operated on between July 1995 and June 2001. Overall, the isolates were inhibited by the antiseptics at concentrations below those used routinely. In spite of increasing resistance to the various antibiotics used to treat surgical wound infections, no significant variation in the susceptibility to antiseptics was demonstrated during this 6-year study.
Giacometti
A
A
Institute of Infectious Diseases and Public Health, University of Ancona, via Conca, 60020 Ancona, Italy. anconacmi@interfree.it
Cirioni
O
O
Greganti
G
G
Fineo
A
A
Ghiselli
R
R
Del Prete
M S
MS
Mocchegiani
F
F
Fileni
B
B
Caselli
F
F
Petrelli
E
E
Saba
V
V
Scalise
G
G
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001424:Bacterial Infections / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010545:Peroxides / Q000494:pharmacology; D011206:Povidone-Iodine / Q000494:pharmacology; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000382:microbiology*; D013997:Time Factors
D000891:Anti-Infective Agents, Local; D010545:Peroxides; D000644:Quaternary Ammonium Compounds; C469893:dimethyldidecylammonium chloride; C038288:peroxymonosulfate; D011206:Povidone-Iodine