[The roles of apoptosis in lung injury].
Apoptosis serves important roles in organ development, cell differentiation, and the maintenance of homeostasis. Lung injury studies have underlined the role of fibroblast and endothelial cell apoptosis during lung repair from acute lung injuries, and demonstrated apoptosis of alveolar epithelial cells in association with diffuse alveolar damage. Pulmonary fibrosis is characterized by the loss of lung epithelial cells and the proliferation of fibroblasts. It is possible that Fas, Fas ligand, p 53, p 21, and other apoptosis-regulating proteins may play important roles in the pathophysiology of lung injury and fibrosis.
Hagimoto
Naoki
N
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan.
Kuwano
Kazuyoshi
K
Hara
Nobuyuki
N
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000502:physiology; D004847:Epithelial Cells / Q000473:pathology; D053222:Fas Ligand Protein; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000473:pathology* / Q000503:physiopathology; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D011379:Prognosis; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology / Q000503:physiopathology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D019014:fas Receptor / Q000502:physiology
C493956:CDKN1A protein, human; C493957:Cdkn1a protein, mouse; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D016159:Tumor Suppressor Protein p53; D019014:fas Receptor