Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex.
Shiotsu
Yukimasa
Y
Kyowa Hakko Kogyo, Pharmaceutical Laboratories, Suntoh-gun, Shizuoka, Japan. yukimasa.shiotsu@kyowa.co.jp
Soga
Shiro
S
Akinaga
Shiro
S
D016044:Fusion Proteins, bcr-abl / Q000187:drug effects* / Q000502:physiology; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D007783:Lactones / Q000494:pharmacology* / Q000627:therapeutic use; D007938:Leukemia / Q000188:drug therapy
D018841:HSP90 Heat-Shock Proteins; C456099:KF58333; D007783:Lactones; D016044:Fusion Proteins, bcr-abl