Inflammatory signals increase Fas ligand expression by inner ear cells.
There is considerable evidence that hearing and vestibular function can be influenced by immune processes. The inner ear has evolved mechanisms, such as the blood-labyrinthine barrier that limit immune responses and autoimmune processes to reduce the potential for damage to cochlear cells. Recently, expression of Fas ligand (FasL) in some non-lymphoid tissue, as in the anterior chamber of the eye, has been hypothesized to play a role in protection of sensitive organs from activated T-cells. We show that under resting conditions, cochlear cells express little or no FasL. However, after exposure to interferon-gamma in vitro, FasL is induced in many neonatal cochlear cells. In addition, we show that FasL is upregulated in adult cochlear cells after induction of a sterile labyrinthitis in vivo. The induction of FasL by inflammation may serve to limit cochlear immune responses, and to protect sensorineural tissue from immune and autoimmune damage.
Bodmer
Daniel
D
Department of Surgery, Division of Otolaryngology, UCSD School of Medicine and VA Medical Center, La Jolla, CA 92093, USA.
Brors
Dominik
D
Pak
Kwang
K
Keithley
Elizabeth M
EM
Mullen
Lina
L
Ryan
Allen F
AF
Gloddek
Bertrand
B
D000818:Animals; D002478:Cells, Cultured; D053222:Fas Ligand Protein; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000276:immunology / Q000494:pharmacology; D007762:Labyrinthitis / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D015854:Up-Regulation / Q000187:drug effects / Q000276:immunology*; D019014:fas Receptor / Q000276:immunology*
D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D019014:fas Receptor; D007371:Interferon-gamma