Intra-abdominal anaerobic infections: bacteriology and therapeutic potential of newer antimicrobial carbapenem, fluoroquinolone, and desfluoroquinolone therapeutic agents.
Intra-abdominal infections are biphasic, synergistic processes with early peritonitis and bacteremia due to aerobes and a later abscess component due to anaerobes. Although Bacteroides fragilis is the most commonly recognized pathogen, other anaerobes, including other members of the B. fragilis-group species, are major components of infection. Anaerobic bacteremia is often associated with an intra-abdominal source. New antimicrobial agents with anaerobic activity are in various stages of development for the therapy of intra-abdominal infections. The in vitro activity and the currently available sparse clinical data are reviewed for a new carbapenem (ertapenem), several fluoroquinolones (trovafloxacin, moxifloxacin, and gemifloxacin), and a desfluoroquinolone (BMS-284756).
Goldstein
Ellie J C
EJ
R. M. Alden Research Laboratory, Santa Monica, CA, USA; and UCLA School of Medicine, Los Angeles, CA, USA. EJCGMD@aol.com
D018784:Abdominal Abscess / Q000188:drug therapy* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001372:Aza Compounds; D016470:Bacteremia / Q000209:etiology; D001421:Bacteria, Anaerobic; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000382:microbiology; D001441:Bacteroides fragilis / Q000302:isolation & purification*; D015780:Carbapenems / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D000077727:Ertapenem; D024841:Fluoroquinolones / Q000627:therapeutic use; D000077735:Gemifloxacin; D006801:Humans; D007211:Indoles; D007769:Lactams; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000627:therapeutic use; D011804:Quinolines; D015363:Quinolones; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D015780:Carbapenems; D024841:Fluoroquinolones; D007211:Indoles; D007769:Lactams; D009287:Naphthyridines; D011804:Quinolines; D015363:Quinolones; D047090:beta-Lactams; C080163:trovafloxacin; D000077727:Ertapenem; D000077735:Gemifloxacin; D000077266:Moxifloxacin; C419689:garenoxacin