title: Inhibition of IL-12 signaling Stat4/IFN-gamma pathway by rapamycin is associated with impaired dendritic [correction of dendritc] cell function.
authors.affiliation: Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15261, USA.
authors.forename: P-H
authors.initials: PH
authors.lastname: Chiang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: X
authors.initials: X
authors.lastname: Liang
authors.forename: S
authors.initials: S
authors.lastname: Qian
authors.forename: J J
authors.initials: JJ
authors.lastname: Fung
authors.forename: C A
authors.initials: CA
authors.lastname: Bonham
authors.forename: L
authors.initials: L
authors.lastname: Lu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology*; D005434:Flow Cytometry / Q000379:methods; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D016027:Heart Transplantation / Q000276:immunology; D007371:Interferon-gamma / Q000037:antagonists & inhibitors*; D018664:Interleukin-12 / Q000037:antagonists & inhibitors*; D051379:Mice; D008809:Mice, Inbred C3H; D050797:STAT4 Transcription Factor; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*; D020123:Sirolimus / Q000494:pharmacology*; D015534:Trans-Activators / Q000037:antagonists & inhibitors*
chemical_list: D004268:DNA-Binding Proteins; D050797:STAT4 Transcription Factor; C494091:Stat4 protein, mouse; D015534:Trans-Activators; D018664:Interleukin-12; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D020123:Sirolimus