Chemopreventive potential of cyclic diarylheptanoids.
Eleven cyclic diarylheptanoids and seven related compounds were screened as potential antitumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. In addition, the cyclic diarylheptanoid myricanone (2) was examined for antitumor initiating activity in a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA as a promoter. Myricanone (2) exhibited significant antitumor-initiating effect on mouse skin. These data suggest that cyclic, as well as linear, diarylheptanoids might be valuable chemopreventors.
Ishida
Junko
J
Hoshi University, 2-4-41, Ebara, Shinagawa-ku, 142-8501, Tokyo, Japan.
Kozuka
Mutsuo
M
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Nagumo
Seiji
S
Lee
Kuo Hsiung
KH
Nagai
Masahiro
M
D000818:Animals; D000956:Antigens, Viral / Q000187:drug effects; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015197:Carcinogenicity Tests; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000956:Antigens, Viral; D000970:Antineoplastic Agents; C033305:Epstein-Barr virus early antigen