Nutrition in early life. How important is it?
While few would argue the importance of nutrition during adult life, temporary excess or deficiency has typically been thought to be of little long-term consequence. Recent data, summarized above, suggests that this may not be the case during in utero life, when alterations in the quantity or quality of nutrients provided may have life-long consequences. Perhaps even more surprisingly, decisions made in the neonatal period, such as whether to breastfeed or bottle feed, may have impacts on later health that, while small individually, have huge public health implications. Clarification of the links between adult health and fetal/neonatal nutrition are clearly required. Prospective studies, though difficult because of the time involved, will play a key role in this process, as will more basic research on the mechanisms underlying both normal and pathologic fetal development.
Novak
Donald
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Division of Pediatric Gastroenterology, Department of Pediatrics, Box 100296, University of Florida College of Medicine, Gainesville, FL 32610-0296, USA. novakda@peds.ufl.edu
D000596:Amino Acids / Q000378:metabolism; D001724:Birth Weight; D002352:Carrier Proteins / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007228:Infant Nutrition Disorders / Q000150:complications*; D007231:Infant, Newborn; D050356:Lipid Metabolism; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D010927:Placental Insufficiency / Q000150:complications*; D011247:Pregnancy; D012307:Risk Factors
D000596:Amino Acids; D002352:Carrier Proteins; D005947:Glucose