Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.
We analyzed the expression of high in normal-1 (HIN-1), a putative breast tumor suppressor gene, and uteroglobin related protein-1 (UGRP-1), a homologue of HIN-1, in adult and developing mouse tissues. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands. The expression of both genes was detected only at E17.5-18.5 and the HIN-1 messenger RNA was localized to the epithelia of the trachea, bronchi, and uterine glands. The expression of HIN-1 is up-regulated during retinoic acid induced differentiation of bronchial epithelial cells. We also identified two putative Drosophila HIN-1 homologues. The expression of HIN-1 is restricted to terminally differentiated airway epithelial cells in vivo and in vitro implicating HIN-1 in the acquisition or maintenance of terminally differentiated epithelial phenotype.
Porter
Dale
D
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Lahti-Domenici
Jaana
J
Torres-Arzayus
Marisa
M
Chin
Lynda
L
Polyak
Kornelia
K
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D001980:Bronchi / Q000166:cytology; D002352:Carrier Proteins; D002454:Cell Differentiation; D016207:Cytokines / Q000096:biosynthesis*; D004847:Epithelial Cells / Q000166:cytology; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D008168:Lung / Q000196:embryology* / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D010641:Phenotype; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D060765:Secretoglobins; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis*; D014212:Tretinoin / Q000494:pharmacology; D025521:Tumor Suppressor Proteins; D015854:Up-Regulation; D014598:Uteroglobin
D002352:Carrier Proteins; D016207:Cytokines; C434732:SCGB3A1 protein, human; C449940:SCGB3A2 protein, human; D060765:Secretoglobins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D014212:Tretinoin; D014598:Uteroglobin