title: Psychological impact of prophylactic oophorectomy in women at increased risk of developing ovarian cancer: a prospective study.
abstract: OBJECTIVE
  The objectives of this study were twofold: to prospectively assess whether expressed intention to undergo prophylactic oophorectomy translated into uptake and to evaluate the psychological impact of the procedure in a sample of unaffected women with a strong family history of breast/ovarian cancer.
  
  
  METHODS
  Ninety-five women, initially assessed at the time of their first attendance at a familial cancer clinic, were followed-up 3 years later. A total of 22 women (23.2%) in this study had undergone a prophylactic oophorectomy. Ten women (10.5%) who had undergone a prophylactic oophorectomy during the 3-year follow-up period were compared to 73 women (76.9%) who did not have a prophylactic oophorectomy. Twelve women (12.6%) who had the procedure prior to study entry were also assessed for psychological adjustment and associated information needs.
  
  
  RESULTS
  Age emerged as a significant predictor of uptake of prophylactic oophorectomy (chi(2) = 7.13, P = 0.009). Among those who had the procedure after study entry, a significant reduction in ovarian cancer anxiety was observed (Z = -2.19, P = 0.029). Of the 22 women who had undergone a prophylactic oophorectomy in total (both before and after study entry), 86.4% reported a high degree of satisfaction with their decision to have the procedure. A low level of screening uptake was also reported by women who did not have a prophylactic oophorectomy but for whom screening was recommended.
  
  
  CONCLUSIONS
  Findings demonstrate that prophylactic oophorectomy is successful in reducing anxiety about ovarian cancer. The results also suggest that women perceive that the benefit of anxiety reduction may outweigh the potentially adverse effects of the procedure, given that women expressed a high level of satisfaction with their decision.
authors.affiliation: Department of Medical Oncology, Prince of Wales Hospital, Sydney, Australia. k.tiller@unsw.edu.au
authors.forename: K
authors.initials: K
authors.lastname: Tiller
authors.forename: B
authors.initials: B
authors.lastname: Meiser
authors.forename: P
authors.initials: P
authors.lastname: Butow
authors.forename: M
authors.initials: M
authors.lastname: Clifton
authors.forename: B
authors.initials: B
authors.lastname: Thewes
authors.forename: M
authors.initials: M
authors.lastname: Friedlander
authors.forename: K
authors.initials: K
authors.lastname: Tucker
mesh_terms: D000328:Adult; D000367:Age Factors; D001007:Anxiety / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000517:prevention & control* / Q000523:psychology / Q000601:surgery*; D010052:Ovariectomy / Q000523:psychology*; D017060:Patient Satisfaction; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors