Lack of association between an estrogen receptor 1 gene polymorphism and Parkinson's disease with dementia.
OBJECTIVE
To test for an association between an estrogen receptor 1 (ESR1) gene polymorphism and Parkinson's disease with dementia (PDD) in Finnish subjects.


METHODS
Forty-one clinically demented and pathologically confirmed PDD patients and 59 cognitively intact aged individuals with normal neuropathology were genotyped for the ESR1 PvuII polymorphism.


RESULTS
We found no significant differences in the genotype or allele frequencies when the PDD patients were compared with the controls. Nor were there any significant differences in these frequencies when the PDD patients with coexisting Alzheimer's disease pathology were compared with the control group.


CONCLUSIONS
We failed to demonstrate an association between dementia-associated PD and the ESR1 PvuII polymorphism in Finnish subjects.
Mattila
K M
KM
Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland. kari.m.mattila@uta.fi
Rinne
J O
JO
Röyttä
M
M
Laippala
P
P
Lehtimäki
T
T
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000209:etiology; D016022:Case-Control Studies; D003704:Dementia / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*; D012307:Risk Factors
D011960:Receptors, Estrogen