Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients.
In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.
Xu
Li
L
PHLS Antiviral Susceptibility Unit, Division of Immunity and Infection, University of Birmingham Medical School, Birmingham, UK.
Hué
Stéphane
S
Taylor
Stephen
S
Ratcliffe
Daina
D
Workman
Judith A
JA
Jackson
Susan
S
Cane
Patricia A
PA
Pillay
Deenan
D
D019380:Anti-HIV Agents / Q000378:metabolism*; D001483:Base Sequence; D017931:DNA Primers; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000737:chemistry / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism*
D019380:Anti-HIV Agents; D017931:DNA Primers; D015700:HIV Envelope Protein gp41; D010446:Peptide Fragments; D000077560:Enfuvirtide