title: Structure-activity relationships in the acronycine series.
abstract: Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships demonstrated the crucial role of the 1,2-double bond. A hypothesis of bioactivation into 1,2-epoxide led to the development of a series of 1,2-dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diesters that exhibited an increased potency when compared with the parent compound.
authors.affiliation: Laboratoire de Pharmacognosie de l'Université René Descartes, U.M.R. / C.N.R.S. Faculté des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, Paris, F-75006, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Seguin
authors.forename: Fraņois
authors.initials: F
authors.lastname: Tillequin
mesh_terms: D000175:Acronine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D000175:Acronine