title: Use of plasma clearance of technetium Tc 99m pentetate to estimate renal clearance during postnatal development in pigs.
abstract: OBJECTIVE
  To compare renal clearance of technetium Tc 99m pentetate with plasma clearance by use of a glomerular filtration rate technique in pigs from 3 to 24 weeks of age.
  
  
  METHODS
  24 female pigs.
  
  
  METHODS
  At the time of investigation, 5 pigs were 3 weeks old, 6 pigs were 6 weeks old, 8 pigs were 12 weeks old, and 5 pigs were 24 weeks old. Plasma clearance of technetium Tc 99m pentetate was measured by the use of a single injection technique followed by collection of multiple blood samples until 5 hours after the injection. Simultaneously, urine was collected through a urinary catheter, and the renal clearance of technetiumTc 99m pentetate was calculated. Plasma clearance of technetium Tc 99m pentetate was correlated with the renal clearance (r = 0.95). Plasma clearance was higher than renal clearance at all ages (mean, 5.8%), indicating extrarenal clearance of technetium Tc 99m pentetate or methodologic errors. Volume of distribution increased with increasing age but decreased as a fraction of body weight.
  
  
  CONCLUSIONS
  Plasma clearance of technetium Tc 99m pentetate estimates renal clearance with acceptable precision when using single injection technique and multiple biood samples in pigs from 3 to 24 weeks of age.
authors.affiliation: Institute of Experimental Clinical Research, University of Aarhus, Denmark.
authors.forename: Anni
authors.initials: A
authors.lastname: Eskild-Jensen
authors.forename: Michael
authors.initials: M
authors.lastname: Rehling
authors.forename: Asker S
authors.initials: AS
authors.lastname: Nielsen
authors.forename: Lene E
authors.initials: LE
authors.lastname: Nielsen
authors.forename: Jørgen
authors.initials: J
authors.lastname: Frøkiaer
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary; D007668:Kidney / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D013552:Swine / Q000378:metabolism*; D016284:Technetium Tc 99m Pentetate / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate