Valproate-associated dysmyelopoiesis in elderly patients.
Sodium valproate is widely prescribed for patients with epilepsy and psychiatric disorders. Hematologic toxic effects have been largely described in pediatric patients, and dysmyelopoiesis is reported rarely. We describe 2 elderly patients with valproate-associated dysmyelopoiesis and postulate that this particular side effect may be much more common than currently recognized. A correct diagnosis is important for acute patient anagement and for prognostication.
So
Chi-chiu
CC
Department of Pathology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
Wong
Kit-fai
KF
D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced* / Q000473:pathology; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid