title: Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.
abstract: Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
authors.affiliation: Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, Belgium.
authors.forename: Weidong
authors.initials: W
authors.lastname: He
authors.forename: Miroslav
authors.initials: M
authors.lastname: Cik
authors.forename: Luc
authors.initials: L
authors.lastname: Van Puyvelde
authors.forename: Jacky
authors.initials: J
authors.lastname: Van Dun
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Anne
authors.initials: A
authors.lastname: Lesage
authors.forename: Ilse
authors.initials: I
authors.lastname: Van der Lindin
authors.forename: Josée E
authors.initials: JE
authors.lastname: Leysen
authors.forename: Walter
authors.initials: W
authors.lastname: Wouters
authors.forename: Simon G
authors.initials: SG
authors.lastname: Mathenge
authors.forename: Francis P
authors.initials: FP
authors.lastname: Mudida
authors.forename: Norbert
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008958:Models, Molecular; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029645:Thymelaeaceae / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D009414:Nerve Growth Factors; D013729:Terpenes; D014315:Triterpenes; C417923:kirkinine; C011309:mezerein