The role of genomic instabilities in affecting treatment responses of colorectal cancer.
Colorectal cancer is one of the most common tumors worldwide. The knowledge gained on its biology and molecular changes is helping us to choose the best chemotherapeutic treatment. Two different pathways, i.e. the chromosomal and microsatellite instabilities, give the same result but with totally different biological behaviors. In fact, the response to treatment with 5-FU or platinum compounds is dramatically different in both settings. In the future, the use of these compounds should require molecular testing of the specimen prior to treatment.
Ricciardiello
Luigi
L
Dipartimento di Medicina Interna e Gastroenterologia, Università di Bologna, Italy. ricciard@md.unibo.it
Bazzoli
Franco
F
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male
D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil