title: [Effect of nitric oxide on ATPase activity of smooth muscle actomyosin].
abstract: The effects of nitric oxide donor sodium nitroprusside (SNP) on ATPase activities of smooth muscle actomyosin and myosin were investigated. The effect of SNP on actomyosin ATPase activity was biphasic: the low concentration of this reagent increased the actomyosin ATPase activity while the high concentration exerted opposite effect. These effects were similar to those induced by the specific thiol-alkylating agent N-ethylmaleimide. These data demonstrate that nitric oxide exert the direct effect on smooth muscle contractile proteins. Such effect may be involved in physiological action of NO on smooth muscle.
authors.affiliation: Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv.
authors.forename: O Ia
authors.initials: OIa
authors.lastname: Andrukhov
authors.forename: V M
authors.initials: VM
authors.lastname: Danylova
authors.forename: V S
authors.initials: VS
authors.lastname: Babiĭchuk
authors.forename: V F
authors.initials: VF
authors.lastname: Sahach
mesh_terms: D000205:Actomyosin / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D009130:Muscle, Smooth / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009569:Nitric Oxide / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D013552:Swine
chemical_list: D009599:Nitroprusside; D009569:Nitric Oxide; D000205:Actomyosin; D000251:Adenosine Triphosphatases