[123I]-phenylpentadecanoic acid uptake in patients with dilated cardiomyopathy.
BACKGROUND
The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM).


METHODS
10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions.


RESULTS
All patients showed non-homogeneous tracer uptake defects for 201TI and IPPA. k(1) was significantly higher in DCM patients than controls. k(1) showed significant inverse correlation between cardiac index, left-ventricular ejection fraction, left-ventricular enddiastolic pressure and echocardiographic left-ventricular ejection fraction.


CONCLUSIONS
We presume that an increased regional rate constant of IPPA influx into the myocardial tissue in patients with DCM reflects a compensatory mechanism of altered myocardium.
Miche
Eckart
E
Herz-Kreislauf-Zentrum Gernsbach/Schwarzwald, Germany. cardiol@hkz-gernsbach.de
Radzewitz
Andrea
A
Notohamiprodjo
Gunawan
G
Baller
Detlev
D
Kloppe
Axel
A
Eckert
Siegfried
S
Gleichmann
Ulrich
U
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000000981:diagnostic imaging / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; C025391:omega-(4-iodophenyl)pentadecanoic acid