[Activation of key proenzymes of the blood coagulation system by the fibrin E fragment].
Plasminogen and prothrombin are key proenzymes of fibrinolytic and clotting system. It is known that they can be activated by indirect activators streptokinase and staphylocoagulase. In this paper it is shown that fibrin E fragment purified from DD-E complex induced catalytic activity in plasminogen and clotting activity in prothrombin. Streptokinase increased 2 times the rate of catalytic activity induction by E fragment in prothrombin. It's possibly that process is one of the factors providing for rethrombosis after thrombolytic therapy of myocardial infarction.
Platonova
T M
TM
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Slomins'kyĭ
O Iu
OIu
Chernyshenko
T M
TM
Makohonenko
Ie M
IeM
D001779:Blood Coagulation Factors / Q000378:metabolism*; D002384:Catalysis; D003030:Coagulase / Q000378:metabolism; D004792:Enzyme Precursors / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D013300:Streptokinase / Q000378:metabolism; D015912:Thrombolytic Therapy
D001779:Blood Coagulation Factors; D003030:Coagulase; D004792:Enzyme Precursors; D005338:Fibrin Fibrinogen Degradation Products; D013300:Streptokinase