Partial synthesis of 23-hydroxyursolic acid isolated from medicinal plants of the Rubiaceae family.
23-Hydroxyursolic acid (2), previously isolated from medicinal plants of the Rubiaceae family, was synthesized in ten steps via methyl 23-hydroxy-3-oxours-12-en-28-oate (5) from commercially available ursolic acid (6).
Bore
Lothar
L
Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755-3564, USA.
Honda
Tadashi
T
Gribble
Gordon W
GW
D007259:Infrared Rays; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D000097245:Ursolic Acid
D009828:Oleanolic Acid; D014315:Triterpenes; D000097245:Ursolic Acid; C469885:23-hydroxyoleanolic acid; C469886:methyl 23-hydroxy-3-oxours-12-en-28-oate; C469884:23-hydroxyursolic acid