title: [Biodemes of Trypanosoma cruzi strains isolated from humans from three endemic areas in Minas Gerais State].
abstract: In order to study the biological behavior of T. cruzi strains and to determine a putative association between their biodeme and the clinical forms of Chagas disease, 14 strains isolated from humans were evaluated. The individuals were from the municipalities of Pains, Iguatama and Berilo (Minas Gerais State). The biological behavior was evaluated in albino swiss mice, weighing 10 to 15 grams, which were infected with 1x10(4) blood tripomastigotes. The infectivity, parasitemia, tripomastigote morphology, virulence and the tissue distribution of the protozoan were analyzed. A behavior similar to biodeme II (São Felipe strain) was observed in 9 strains, while 5 stocks were characterized as belonging to biodeme III. It was not possible to establish a relationship between the biodeme strain and the severity of the disease in the patients.
authors.affiliation: Departamento de Medicina Tropical, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ. rdevera@gene.dbbm.fiocruz.br
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Devera
authors.forename: Ximena
authors.initials: X
authors.lastname: Illarramendi
authors.forename: Roberto
authors.initials: R
authors.lastname: Montoya-Araújo
authors.forename: Claude
authors.initials: C
authors.lastname: Pirmez
authors.forename: Octavio
authors.initials: O
authors.lastname: Fernandes
authors.forename: José Rodrigues
authors.initials: JR
authors.lastname: Coura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D009928:Organ Specificity; D018512:Parasitemia / Q000469:parasitology*; D013045:Species Specificity; D014349:Trypanosoma cruzi / Q000145:classification / Q000472:pathogenicity*; D014352:Trypanosomiasis / Q000401:mortality / Q000469:parasitology*; D014774:Virulence