title: Oxygen saturation as a screening test for critical congenital heart disease: a preliminary study.
abstract: The aim of this study was to assess the utility of arm and leg oxygen saturation as a candidate screening test for the early detection of ductal-dependent left heart obstructive disease. We measured arm and leg oxygen saturation in 2876 newborns admitted to well baby nurseries and 32 newborns with congenital heart disease. Fifty-seven newborns in the well baby nurseries (0.02%) had an abnormal test (leg saturation less than 92% in room air or 7% lower saturation in the leg than in the arm). Four of the 57 had critical congenital heart disease, including 1 with coarctation of the aorta. Of the 32 newborns with congenital heart disease, 11/13 (85%) with left heart obstructive disease had abnormal oxygen saturation tests, as did 15/19 (79%) with other forms of congenital heart disease. Pulse oximetry deserves further study as a screening test for critical congenital heart disease.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Hoke
authors.forename: P K
authors.initials: PK
authors.lastname: Donohue
authors.forename: P K
authors.initials: PK
authors.lastname: Bawa
authors.forename: R D
authors.initials: RD
authors.lastname: Mitchell
authors.forename: A
authors.initials: A
authors.lastname: Pathak
authors.forename: P C
authors.initials: PC
authors.lastname: Rowe
authors.forename: B J
authors.initials: BJ
authors.lastname: Byrne
mesh_terms: D015142:Baltimore / Q000453:epidemiology; D001724:Birth Weight / Q000502:physiology; D016022:Case-Control Studies; D015331:Cohort Studies; D004452:Echocardiography; D005121:Extremities / Q000098:blood supply; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007229:Infant Welfare; D007231:Infant, Newborn; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D015995:Prevalence; D012680:Sensitivity and Specificity; D018881:Suburban Health; D014504:Urban Health
chemical_list: D010100:Oxygen