Effect of myelopeptide-2 on the development of spontaneous and urethane-induced tumors in mice.
We studied the effect of endogenous immunoregulatory myelopeptide-2 on the development of spontaneous and urethane-induced lung adenomas. Long-term treatment with myelopeptide-2 (25 injections) in parallel with urethane poisoning decreased animal mortality caused by this carcinogen. Short-term treatment with myelopeptide-2 decreased the number of spontaneous and urethane-induced lung tumors in mice. Myelopeptide-2 delayed the appearance of urethane-induced tumors irrespective of the number of injections.
Mikhailova
A A
AA
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Kirilina
E A
EA
Morozova
O V
OV
Turusov
V S
VS
D000236:Adenoma / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D008175:Lung Neoplasms / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000627:therapeutic use*; D014520:Urethane
D000970:Antineoplastic Agents; D002273:Carcinogens; D009842:Oligopeptides; C048617:myelopeptides; D014520:Urethane