New microencapsulated sunscreens: technology and comparative evaluation.
The aim of this work is to obtain new technologically improved microencapsulated sunscreens characterised by UV-radiation stability, good substantivity, low toxicity, a better tolerability and easiness to formulation. For this purpose we prepared two different systems using semisynthetic Hyaluronic Acid (HA) benzyl ester and a synthetic polymer (patent pending). We obtained these systems using two different methodologies: emulsification/solvent evaporation and emulsification/solvent extraction. The comparison between the two formulated systems was carried out in terms of their chemical-physical and biological properties.
Anselmi
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Dipartimento Farmaco Chimico Tecnologico and Scuola di Specializzazione in Scienza e Tecnologia Cosmetiche, Università di Siena, Via della Diana 2, 53100, Siena, Italy. anselmic@unisi.it
Centini
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Rossi
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Ricci
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Rastrelli
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Andreassi
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Buonocore
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La Rosa
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D002214:Capsules; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004655:Emulsions; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000737:chemistry; D010316:Particle Size; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D013818:Thermogravimetry; D014466:Ultraviolet Rays
D002214:Capsules; D004655:Emulsions; D013473:Sunscreening Agents; D006820:Hyaluronic Acid