Methylenedioxy- and methoxyflavones from Melicope coodeana syn. Euodia simplex.
Three new natural products, 3,8-dimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone, 3,6,8-trimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone and 3,6,8,3',4'-pentamethoxy-5,7-dihydroxyflavone were isolated from Melicope coodeana syn. Euodia simplex (Rutaceae) along with 3,6,3'-trimethoxy-5,7,4'-trihydroxyflavone and 3,3'-dimethoxy-5,7,4'-trihydroxyflavone. The structural assignments are based on (1)H and (13)C NMR data, including discussion of the chemical shifts of C-2 in 3,5-dihydroxy- and 3-methoxy-5-hydroxyflavones. The presence of highly methoxylated and methylenedioxyflavones is characteristic of the genus Melicope, and the present findings support the recent transfer of Euodia simplex to Melicope.
Simonsen
Henrik T
HT
Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Larsen
Michael D
MD
Nielsen
Merete W
MW
Adsersen
Anne
A
Olsen
Carl Erik
CE
Strasberg
Dominique
D
Smitt
Ulla W
UW
Jaroszewski
Jerzy W
JW
D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D027821:Rutaceae / Q000737:chemistry*; D013057:Spectrum Analysis
D005419:Flavonoids