title: Update in immunosuppression.
abstract: This article briefly reviews the current status of renal transplantation and the current focus of immunosuppression in the prevention of chronic rejection. Four paradigms involved in the understanding of the immune system and their role in rejection are discussed. The paradigms are co-stimulation, quantifying immunosuppression, changing the direction of lymphocytes, and inhibition of antibody. Examples of each of these paradigms are given.
authors.affiliation: University of Alberta Hospital, Edmonton, Alberta, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Huizinga
mesh_terms: D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects / Q000379:methods* / Q000639:trends; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents