Novel magnified endoscopic findings of microvascular architecture in intramucosal gastric cancer.
BACKGROUND
The color change observed endoscopically in early gastric cancer is thought to correlate with vascular density and architecture. This study investigated the endoscopic microvascular architecture in intramucosal gastric carcinoma in vivo.


METHODS
Intramucosal gastric carcinomas without ulceration in 27 patients were studied by using a new magnifying upper endoscope with attention to microvascular findings. The carcinomas were divided into two major types histologically: differentiated (18) and undifferentiated (9).


RESULTS
A regular subepithelial capillary network was demonstrated in noncancerous mucosa. The appearance of the carcinomas differed depending on histologic differentiation. With all of the differentiated carcinomas, there was a well-demarcated area where the regular capillary pattern of noncancerous mucosa had disappeared and irregular microvessels were proliferating. In contrast, with undifferentiated carcinomas there was only an ill-defined area with disappearance or a reduction in the density of capillaries in the noncancerous mucosa.


CONCLUSIONS
Magnified endoscopic observation of microvessels may be of assistance in the identification of intramucosal gastric carcinomas that exhibit only subtle changes in color and shape at standard endoscopy.
Yao
Kenshi
K
Department of Gastroenterology, Fukuoka University, Chikushi Hospital, Fukuoka, Japan.
Oishi
Tatsuhiro
T
Matsui
Toshiyuki
T
Yao
Tsuneyoshi
T
Iwashita
Akinori
A
D019723:Endoscopes; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D008833:Microcirculation; D008853:Microscopy; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology