title: Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia.
abstract: Tranexamic acid (an antifibrinolytic agent) is of proven benefit in the treatment of bleeding in patients with congenital and acquired coagulation disorders. We report the case of a patient with an acquired Factor VIII inhibitor, who was on a prophylactic dose of tranexamic acid because of recurrent bleeding episodes and developed a pulmonary embolism. Although studies using tranexamic acid have not shown a definite increased risk for the development of venous thrombosis, this is the likely cause of the pulmonary embolism in this patient.
authors.affiliation: Department of Hematology, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia.
authors.forename: Minakshi
authors.initials: M
authors.lastname: Taparia
authors.forename: Frank T
authors.initials: FT
authors.lastname: Cordingley
authors.forename: Michael F
authors.initials: MF
authors.lastname: Leahy
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D005169:Factor VIII / Q000276:immunology; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006470:Hemorrhage / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000139:chemically induced*; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000933:Antifibrinolytic Agents; D001323:Autoantibodies; D014148:Tranexamic Acid; D005169:Factor VIII