Checking that replication breakdown is not terminal.
Two new studies help to clarify the relationship between checkpoint proteins, recombination, and replication fork integrity.
Carr
Antony M
AM
Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. a.m.carr@sussex.ac.uk
D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D019457:Chromosome Breakage; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D004261:DNA Replication; D004271:DNA, Fungal / Q000096:biosynthesis / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases; D011995:Recombination, Genetic; D012264:Ribonucleotide Reductases / Q000378:metabolism; D016196:S Phase; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D012568:Schizosaccharomyces / Q000378:metabolism / Q000502:physiology
D018797:Cell Cycle Proteins; D004271:DNA, Fungal; D004277:DNA, Single-Stranded; D005656:Fungal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; D004247:DNA; D012264:Ribonucleotide Reductases; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C088937:MEC1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases