Preparation and spectroscopic studies of an inclusion complex of adenine with beta-cyclodextrin in solution and in the solid state.
The interaction between adenine and beta-CD has been investigated in solution and in the solid state by several analytical techniques, primarily by 1H-NMR, 2D ROESY and fluorescence spectra, and secondarily by other important techniques, for example, Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The association constant and 1:1 nature of the complex between adenine and beta-CD in solution were determined by fluorescence spectroscopy. A spatial configuration for the complex in solution is proposed from analysis of the 1H-NMR and 2D ROESY data. The Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) data are consistent with the formation of an inclusion complex. In addition, a solid inclusion complex of adenine with beta-CD was synthesized by the coprecipitation method.
Hao
Xu
X
The Test and Analysis Center of Shanxi University, Taiyuan, PR China. xuhao16@hotmail.com
Liang
Chen
C
Jian-Bin
Chao
C
D000225:Adenine / Q000032:analysis / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000032:analysis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D000225:Adenine; C031215:betadex