Putative drug-related pemphigus foliaceus in four dogs.
Four dogs developed cutaneous lesions following the administration of various antibiotics. Histopathology of the lesions was compatible with pemphigus foliaceus, although apoptotic cells suggestive of erythema multiforme were seen in two cases. In two dogs the lesions resolved after 7.5-8.5 months of immune-suppressive treatment. No recurrence was seen during the follow-up period (3 and 4.5 years). The lesions in the other two dogs resolved within 3 weeks to 3 months following discontinuation of the antibiotic. No recurrence of clinical signs occurred during the follow-up period (1 and 4 years, respectively).
White
Stephen D
SD
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA. sdwhite@ucdavis.edu
Carlotti
Didier N
DN
Pin
Didier
D
Bonenberger
Terri
T
Ihrke
Peter J
PJ
Monet
Eric
E
Nishifuji
Koji
K
Iwasaki
Toshiroh
T
Papich
Mark G
MG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D003875:Drug Eruptions / Q000175:diagnosis / Q000662:veterinary*; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D010392:Pemphigus / Q000175:diagnosis / Q000662:veterinary*
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents