title: A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia.
abstract: OBJECTIVE
  To determine the effects of long-term transdermal administration (range, 4-30 days; mean +/- SD, 11.1+/-7.2 days) of isosorbide dinitrate, a nitric oxide donor, in preeclamptic women.
  
  
  METHODS
  We studied uterine and fetoplacental circulation of 12 preeclamptic women with oligohydramnios and an elevated pulsatility index in the uterine arteries.
  
  
  RESULTS
  Transdermal isosorbide dinitrate significantly suppressed the blood pressure of patients. Pulsed Doppler ultrasonography revealed that the average pulsatility index in the uterine arteries was significantly reduced by treatment with isosorbide dinitrate (P < .003). The average pulsatility index in the umbilical artery was also significantly reduced (P < .004). Furthermore, the size of the amniotic fluid pocket increased approximately 4-fold by treatment with isosorbide dinitrate.
  
  
  CONCLUSIONS
  Long-term transdermal administration of isosorbide dinitrate improves fetoplacental circulation and may be effective therapy for avoiding maternal hypertension and oligohydramnios in some preeclamptic women.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
authors.forename: Mikiya
authors.initials: M
authors.lastname: Nakatsuka
authors.forename: Masayo
authors.initials: M
authors.lastname: Takata
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tada
authors.forename: Kazuo
authors.initials: K
authors.lastname: Asagiri
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Habara
authors.forename: Soichi
authors.initials: S
authors.lastname: Noguchi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kudo
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000627:therapeutic use*; D020030:Nitric Oxide Donors / Q000008:administration & dosage / Q000627:therapeutic use*; D021041:Placental Circulation / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011673:Pulsatile Flow / Q000187:drug effects; D013997:Time Factors
chemical_list: D020030:Nitric Oxide Donors; D007548:Isosorbide Dinitrate