title: A case of cold-dependent exercise-induced anaphylaxis.
abstract: Exercise-induced anaphylaxis (EIA) is a form of physical urticaria that is induced by exercise. A 16-year-old Japanese boy had a 4-year history of recurrent wealing and dyspnoea after physical exercise such as jogging, playing handball or riding a bicycle in winter. The episodes were not associated with ingestion of foods including wheat or soya bean. A provocation test, with 15 min of exercise and 2 min of cold stimulation immediately before or immediately after the exercise, elicited a weal that was localized to the test area. A challenge test with ingestion of boiled soya beans and exercise did not elicit a weal. Therefore, in this case, cold exposure, but not food ingestion, was essential for inducing EIA. Cold-dependent EIA is different from cold urticaria, food-dependent EIA, cholinergic urticaria and cold-induced cholinergic urticaria, and may be a distinct entity.
authors.affiliation: Department of Dermatology, Ehime University School of Medicine, Shigenobucho, Ehime 791-0295, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ii
authors.forename: K
authors.initials: K
authors.lastname: Sayama
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000293:Adolescent; D003080:Cold Temperature / Q000009:adverse effects*; D003937:Diagnosis, Differential; D015444:Exercise; D005080:Exercise Test / Q000009:adverse effects; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D010323:Passive Cutaneous Anaphylaxis; D012882:Skin Tests