The road less traveled: transport of Legionella to the endoplasmic reticulum.
Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in transporting Legionella to the ER.
Roy
Craig R
CR
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA. craig.roy@yale.edu
Tilney
Lewis G
LG
D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology / Q000378:metabolism*; D018870:Endoplasmic Reticulum, Rough / Q000378:metabolism / Q000382:microbiology* / Q000648:ultrastructure; D006801:Humans; D016952:Legionella pneumophila / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D007877:Legionnaires' Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology* / Q000648:ultrastructure; D010587:Phagocytosis / Q000276:immunology; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology* / Q000648:ultrastructure; D021381:Protein Transport / Q000276:immunology*; D014617:Vacuoles / Q000378:metabolism / Q000382:microbiology / Q000648:ultrastructure
D001426:Bacterial Proteins