The biosynthesis of beta-carboline and quinolizidine alkaloids of Alangium lamarckii.
The incorporation of tryptamine, dopamine, N-deacetylisoipecoside, N-deacetylipecoside into alangimarckine, deoxytubulosine and ankorine and of strictosidine and vincoside into alangimarckine and deoxytubulosine in young Alangium lamarckii Thw. (Alangiaceae) has been studied and specific utilisation of N-deacetylisoipecoside demonstrated. Parallel experiments with nordeoxytubulosine and deoxytubulosine suggested that O-methylation precedes condensation of protoemetine with tryptamine and further the reduction of ethylene side chain takes place before condensation. Hydroxylation at C-8 in the trans-quinolizidine moiety is the terminal step in the biosynthesis of alangimarckine.
Jain
Sudha
S
Department of Chemistry, Lucknow University, Lucknow, 226 007, India. jainsudha2@rediffmail.com
Sinha
Archana
A
Bhakuni
Dewan S
DS
D032604:Alangiaceae / Q000737:chemistry* / Q000378:metabolism; D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry; D002243:Carbolines / Q000737:chemistry*; D015394:Molecular Structure; D011807:Quinolizines / Q000737:chemistry*; D013057:Spectrum Analysis
D000470:Alkaloids; D002243:Carbolines; D011807:Quinolizines