Hyperuricemia and gout in renal transplant recipients.
Hyperuricemia, unlike clinical gout, is extremely common in renal transplant patients. The high prevalence of hyperuricemia is related to prolonged exposure to cyclosporine rather than to its dose or serum concentration. Serum creatinine levels do not show significant correlation with hyperuricemia, behaving more like a surrogate marker for cyclosporine dose and trough level. The low incidence of gout in renal transplant patients, despite the hyperuricemia, may be related to the prolonged immunosuppression effect.
Abdelrahman
Mohammad
M
Nephrology Department, Kanoo Kidney Center, Dammam Central Hospital, Saudi Arabia. mrabdelrahman@hotmail.com
Rafi
Ali
A
Ghacha
Reda
R
Youmbissi
J T
JT
Qayyum
Tahir
T
Karkar
Ayman
A
D000328:Adult; D015415:Biomarkers / Q000097:blood; D015984:Causality; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006073:Gout / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013223:Statistics as Topic; D013997:Time Factors; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood
D015415:Biomarkers; D007166:Immunosuppressive Agents; D014527:Uric Acid; D016572:Cyclosporine; D003404:Creatinine