Investigation of 4,5-epoxymorphinan degradation during analysis by HPLC.
Compounds of the 4,5-epoxymorphinan series have been shown to degrade in solution to the corresponding 2,2'-dimers when stored in amber glass HPLC vials. A colorant in the glass has been shown to catalyze the degradation. Although amber glass is routinely used to protect solutions from light degradation, it should not be used without evaluating its effect on sample stability.
Quarry
Mary Ann
MA
DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880, USA. maquarry@alum.villanova.edu
Sebastian
Dolores S
DS
Diana
Frank
F
D002614:Chelating Agents; D002851:Chromatography, High Pressure Liquid; D004349:Drug Packaging; D004355:Drug Stability; D004492:Edetic Acid; D004852:Epoxy Compounds / Q000032:analysis*; D005898:Glass; D007202:Indicators and Reagents; D007501:Iron / Q000032:analysis; D009019:Morphinans / Q000032:analysis*; D009266:Nalbuphine / Q000032:analysis; D009270:Naloxone / Q000032:analysis; D010111:Oxymorphone / Q000032:analysis; D012015:Reference Standards; D013056:Spectrophotometry, Ultraviolet
D002614:Chelating Agents; D004852:Epoxy Compounds; D007202:Indicators and Reagents; D009019:Morphinans; D009270:Naloxone; D004492:Edetic Acid; D010111:Oxymorphone; D007501:Iron; D009266:Nalbuphine