Influence of the APOC3 -2854T>G polymorphism on plasma lipid levels: effect of age and gender.
The APOC3 -2854T>G polymorphism lies in the APOC3-A4 intergenic region. In a group of healthy adults, this polymorphism was associated with circulating triglycerides, with 55% lower fasting levels in the homozygous wild-type (TT) compared to the homozygous rare allele (GG) genotype. Age and gender had a significant impact on genotype-triglyceride interactions.
Minihane
Anne Marie
AM
The Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Whiteknights, UK. a.m.minihane@reading.ac.uk
Finnegan
Yvonne E
YE
Talmud
Philippa
P
Leigh-Firbank
Elizabeth C
EC
Williams
Christine M
CM
D000328:Adult; D000367:Age Factors; D000368:Aged; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics*; D001835:Body Weight / Q000235:genetics; D021901:DNA, Intergenic; D005215:Fasting; D005260:Female; D006720:Homozygote; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D021901:DNA, Intergenic; D008055:Lipids; D014280:Triglycerides