title: Sarcolemmal K(ATP) channel triggers opioid-induced delayed cardioprotection in the rat.
abstract: Recently, the involvement of sarcolemmal K(ATP) (sarcK(ATP)) channels in ischemic and pharmacological preconditioning (IPC and PPC) has been minimized by numerous studies suggesting a primary role for mitochondrial K(ATP) (mitoK(ATP)) channels in early and delayed cardioprotection. Although the mitoK(ATP) channel has clearly been shown to be a distal effector of delayed IPC and PPC, studies implicating it as a trigger of protection in delayed IPC are lacking. Accordingly, we characterized the role of cardiac K(ATP) channels as triggers or distal effectors of delayed cardioprotection induced by opioids in rats, and the data suggest that the sarcK(ATP) channel triggers and that the mitoK(ATP) channel is a distal effector of opioid-induced delayed cardioprotection.
authors.affiliation: Medical College of Wisconsin, Department of Pharmacology and Toxicology, Milwaukee, Wis 53226, USA.
authors.forename: Hemal H
authors.initials: HH
authors.lastname: Patel
authors.forename: Anna K
authors.initials: AK
authors.lastname: Hsu
authors.forename: Jason N
authors.initials: JN
authors.lastname: Peart
authors.forename: Garrett J
authors.initials: GJ
authors.lastname: Gross
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001549:Benzamides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D019157:Ischemic Preconditioning, Myocardial; D007700:Kinetics; D008297:Male; D009203:Myocardial Infarction / Q000517:prevention & control*; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017465:Receptors, Opioid, delta / Q000819:agonists*; D012508:Sarcolemma / Q000378:metabolism
chemical_list: D001549:Benzamides; D002316:Cardiotonic Agents; D010879:Piperazines; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D017465:Receptors, Opioid, delta; C102990:SNC 121; D000255:Adenosine Triphosphate