title: 1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands.
abstract: A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT(7) receptor ligands.
authors.affiliation: NPS Pharmaceuticals Inc., Mississauga, ON, Canada. misaac@npsp.com
authors.forename: Methvin B
authors.initials: MB
authors.lastname: Isaac
authors.forename: Tao
authors.initials: T
authors.lastname: Xin
authors.forename: Anne
authors.initials: A
authors.lastname: O'Brien
authors.forename: David
authors.initials: D
authors.lastname: St-Martin
authors.forename: Angela
authors.initials: A
authors.lastname: Naismith
authors.forename: Neil
authors.initials: N
authors.lastname: MacLean
authors.forename: Julie
authors.initials: J
authors.lastname: Wilson
authors.forename: Lidia
authors.initials: L
authors.lastname: Demchyshyn
authors.forename: Ashok
authors.initials: A
authors.lastname: Tehim
authors.forename: Abdelmalik
authors.initials: A
authors.lastname: Slassi
mesh_terms: D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D008024:Ligands; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C104425:serotonin 7 receptor