title: Won't you be my neighbor? Local induction of arteriogenesis.
abstract: Two recent papers in Cell and Developmental Cell provide evidence that VEGF directs arterial differentiation. Evidence that sensory nerves direct arteriogenesis and that the membrane-spanning Notch signaling system is downstream of VEGF emphasize the paracrine regulation of vessel formation.
authors.affiliation: Schepens Eye Research Institute and Harvard Medical School, Boston, MA 02114, USA. pdamore@vision.eri.harvard.edu
authors.forename: Patricia A
authors.initials: PA
authors.lastname: D'Amore
authors.forename: Yin-Shan
authors.initials: YS
authors.lastname: Ng
mesh_terms: D000818:Animals; D001158:Arteries / Q000196:embryology* / Q000294:innervation* / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D004627:Embryonic Induction / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D008222:Lymphokines / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000235:genetics*; D019899:Paracrine Communication / Q000235:genetics; D010525:Peripheral Nerves / Q000196:embryology* / Q000378:metabolism; D051880:Receptors, Notch; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D008565:Membrane Proteins; D051880:Receptors, Notch; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors