title: Biophysical and microscopic analysis of homologous dermal and fascial materials for facial aesthetic and reconstructive uses.
abstract: OBJECTIVE
  To evaluate the microscopic structure and physical properties of homologous tissue grafts commonly used in aesthetic and reconstructive facial plastic surgery in order to determine specific properties of these materials that may affect their performance in vivo.
  
  
  METHODS
  Two decellularized dermal materials (AlloDerm and DuraDerm) and 2 fascia lata tissue grafts (Tutoplast and cadaveric fascia lata) were examined by light microscopy (hematoxylin-eosin and Movat staining) and scanning electron microscopy. The physical properties of these materials were also examined for thickness, maximum sustainable load, strain, conformability, and elasticity.
  
  
  RESULTS
  Significant differences in microscopic appearance existed between the 2 dermal materials and the 2 fascial materials. AlloDerm and Tutoplast fascia lata retained architecture closer to that of untreated tissue than did DuraDerm and cadaveric fascia lata, respectively. Tutoplast fascia lata and AlloDerm were also stronger than cadaveric fascia lata and DuraDerm, respectively. AlloDerm retained significantly more elasticity than DuraDerm.
  
  
  CONCLUSIONS
  AlloDerm and Tutoplast fascia lata retain more natural architecture and physical properties than do DuraDerm and cadaveric fascia lata, respectively. These differences clearly show the effect of the specific processing of these materials. The alteration in architecture and the degradation of the physical properties of DuraDerm and cadaveric fascia lata may hinder the performance of these grafts in vivo. Further studies on these materials in humans are currently under way.
authors.affiliation: Division of Facial Plastic and Reconstructive Surgery, The New York Eye & Ear Infirmary, 310 E 14th St, Sixth Floor, New York, NY 10003, USA. drsclafani@nyfacialsurgery.com
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Sclafani
authors.forename: Steven A
authors.initials: SA
authors.lastname: McCormick
authors.forename: Rubina
authors.initials: R
authors.lastname: Cocker
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D003094:Collagen / Q000627:therapeutic use / Q000648:ultrastructure*; D020405:Dermis / Q000473:pathology / Q000637:transplantation*; D005145:Face; D005206:Fascia Lata / Q000473:pathology / Q000637:transplantation*; D006801:Humans; D008853:Microscopy; D008855:Microscopy, Electron, Scanning; D019651:Plastic Surgery Procedures / Q000379:methods*; D019737:Transplants
chemical_list: D001672:Biocompatible Materials; D003094:Collagen