Colocalization of CA19-9 and KL-6 to epithelial cells in dilated bronchioles in a patient with idiopathic pulmonary fibrosis complicated by diffuse alveolar damage.
A 73-year-old woman with idiopathic pulmonary fibrosis (IPF) had an elevated serum CA19-9 level, but not KL-6. Her condition worsened and she subsequently died and this was associated with a rise in the serum KL-6 level. At autopsy, the lung showed a honeycomb appearance macroscopically and, microscopically, hyaline membrane formation was seen. Immunohistochemical staining revealed partial colocalization of KL-6 and CA19-9 to dilated bronchiolar cells. These features suggest that the mechanisms that cause the synthesis and release of CA19-9 and KL-6 from damaged lung tissue in IPF are likely to differ from those in diffuse alveolar damage. In addition, serum KL-6 levels may reflect the severity of disease more sensitively than CA19-9 levels.
Shimizu
Yuji
Y
Department of Internal Medicine, Nanokaichi Municipal Hospital, Tomioka, Gunma, Japan. yshimizu@med.gunma-u.ac.jp
Hamada
Tetsuya
T
Tanaka
Yoshiki
Y
Sasaki
Atsushi
A
Nemoto
Toshikazu
T
D000368:Aged; D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D001980:Bronchi / Q000378:metabolism*; D018395:CA-19-9 Antigen / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins; D006801:Humans; D007150:Immunohistochemistry; D018396:Mucin-1; D009077:Mucins; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000378:metabolism* / Q000473:pathology; D020545:Respiratory Mucosa / Q000378:metabolism*; D014018:Tissue Distribution
D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D018395:CA-19-9 Antigen; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins