Properties of polyethylene glycol 660 12-hydroxy stearate at a triglyceride/water interface.
This study proposed a method to understand the surfactant role in the first step of the formulation of a novel generation of lipidic nanocapsules. A dynamic rheological protocol was applied using a pendant drop tensiometer in order to determine the interfacial properties of the initial mixture implied in the first formulation step. The response, in terms of interfacial elasticities, described how this mixture led to monodisperse nanometer size range structures after a physico-chemical constraint.
Heurtault
B
B
Inserm ERIT-M 0104, Ingénierie de la Vectorisation Particulaire, Immeuble IBT, 10, rue A. Boquel, 49100, Angers, France.
Saulnier
P
P
Pech
B
B
Proust
J E
JE
Benoît
J P
JP
D002214:Capsules; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004655:Emulsions; D011092:Polyethylene Glycols / Q000737:chemistry; D012212:Rheology; D013228:Stearates / Q000737:chemistry; D013500:Surface Tension; D013501:Surface-Active Agents; D014280:Triglycerides / Q000737:chemistry*; D014867:Water
D002214:Capsules; D004655:Emulsions; D013228:Stearates; D013501:Surface-Active Agents; D014280:Triglycerides; C466738:polyethylene glycol 660 12-hydroxy stearate; D014867:Water; D011092:Polyethylene Glycols