The increased histamine release in ischaemic heart disease patients undergoing coronaroangiography is not mediated by specific IgE.
BACKGROUND
The release of histamine by iodinated contrast media (ICM) is higher in coronary artery disease patients than in noncoronary patients during coronary angiogram.


METHODS
Eighty-eight patients who underwent a coronary angiography were classified either as having coronary artery disease or as noncoronary patients. Histamine concentration was higher than the 6.8 nM upper limit in 7 cases (group 1), of whom six were coronary artery disease patients. We compared the IgE and complement fractions in plasma of these patients to two control groups with normal histamine blood level, one (group 2) with and the other (group 3) without coronary artery disease.


RESULTS
No difference of total IgE and C(3c) and C(4) complement fractions was found among the three groups. Anti-ioxaglate IgE-RIA was positive in only one patient from group 1. The affinity of drug-IgE binding in the serum of this patient was very low (Kd: 18.7 mM). The level of anti-ICM IgE detected by ioxitalamate- and iomeprol-Sepharose RIA was significantly higher in groups 2 and 3 than in group 1.


CONCLUSIONS
The higher histamine release in ischaemic heart disease patients undergoing coronaroangiography is not mediated by IgE or complement activation. Further studies are needed to investigate the implication of histamine release factors.
Rodriguez
Rosa-Maria
RM
Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition, Equipe INSERM 0014, Faculté de Médecine, BP 184, F-54505 Vandoeuvre-lès-Nancy Cedex, France.
Guéant
J-L
JL
Aimone-Gastin
I
I
Gérard
P
P
Amoghly
F
F
Bellou
A
A
Jullière
Y
Y
Faure
G
G
Danchin
N
N
Romano
A
A
D015932:Complement C3c / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000209:etiology; D007073:Immunoglobulin E / Q000097:blood; D007485:Ioxaglic Acid / Q000009:adverse effects*; D011446:Prospective Studies
D003181:Complement C4; D003287:Contrast Media; D007073:Immunoglobulin E; D015932:Complement C3c; D007485:Ioxaglic Acid