title: Evoked otoacoustic emissions in patients with Ménière's disease.
abstract: OBJECTIVE
  This study investigated whether otoacoustic emissions (OAEs) in patients with Ménière's disease show abnormal properties.
  
  
  BACKGROUND
  Patients with Ménière's disease experience vertigo, tinnitus, and hearing loss. OAEs are sounds generated in the inner ear, and their presence is associated with normal hearing.
  
  
  METHODS
  Click-evoked OAEs and distortion product OAEs were measured in 100 patients with Ménière's disease.
  
  
  RESULTS
  The incidence of the emissions in affected ears (56%) was lower than in unaffected (i.e., contralateral) ears (85%). The mean emission amplitude in affected ears was also significantly lower (2.6 dB), and the mean amplitude in unaffected ears was lower than in normal-hearing ears (5.3 dB). These differences were likely caused by the hearing loss involved. Further, ears with OAEs clearly showed smaller hearing losses than ears without OAEs (24-dB difference). The average hearing loss showed correlations with the emission amplitudes, although this correlation was not very strong; when plotted against the smallest hearing loss, a certain upper boundary for the emission amplitude was present. Also, the amplitude of click-evoked OAEs showed a considerable correlation with the largest of the three distortion product OAEs.
  
  
  CONCLUSIONS
  OAEs in patients with Ménière's disease differed from those in normal-hearing ears but did not differ from those in non-Ménière's ears with equivalent hearing loss. This was best observed by comparing emission amplitude with smallest hearing loss instead of mean hearing loss.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors.forename: Emile
authors.initials: E
authors.lastname: de Kleine
authors.forename: Dionisius J M
authors.initials: DJ
authors.lastname: Mateijsen
authors.forename: Hero P
authors.initials: HP
authors.lastname: Wit
authors.forename: Frans W J
authors.initials: FW
authors.lastname: Albers
mesh_terms: D000161:Acoustic Stimulation; D001299:Audiometry; D001309:Auditory Threshold; D003638:Deafness / Q000209:etiology / Q000503:physiopathology; D004423:Ear / Q000503:physiopathology; D005260:Female; D006309:Hearing; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D010469:Perceptual Distortion