Spontaneous IL-8 production by CD4(+), CD7(+) leukemia cells in erythrodermic Sézary syndrome.
Sézary syndrome has been described as the leukemic form of cutaneous T-cell lymphoma, defined by the presence of CD4(+) T-cells with cerebriform nuclei in the peripheral blood, erythroderma and lymphadenopathy with occasional involvement to lymph nodes, and visceral organs according to course. We report a 48-year-old woman with Sézary syndrome. Most of peripheral blood mononuclear cells (PBMC) showed CD4(+), CD7(+) surface marker while infiltrating cells to the skin consisted of the same percentage of CD4/CD8 cells. CD4(+) cells predominantly expressed IL-8 both in PBMC and the skin, and generated significant amount of IL-8. In contrast, lesional keratinocytes showed only a trace amount of IL-8 when compared to strong expression by infiltrating CD4(+) and CD8(+) cells. These studies suggested that leukemia cell-derived cytokines such as IL-8 might play some role in the induction of erythrodermic features of Sézary syndrome.
Ogawa
Fumihide
F
Department of Dermatology, Nagasaki University School of Medicine, Japan. fogawa-ngs@umin.ac.jp
Shimizu
Kazuhiro
K
Hamasakia
Yo-ichiro
Y
Tanaka
Yoichi
Y
Katayama
Ichiro
I
Yamada
Yasuaki
Y
Tomonaga
Masao
M
D019011:Antigens, CD7 / Q000032:analysis*; D015704:CD4 Antigens / Q000032:analysis*; D016516:CD4-CD8 Ratio; D016207:Cytokines / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000096:biosynthesis*; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D012751:Sezary Syndrome / Q000276:immunology* / Q000473:pathology
D019011:Antigens, CD7; D015704:CD4 Antigens; D016207:Cytokines; D016209:Interleukin-8; D012333:RNA, Messenger