Effects of central opiate and serotoninergic structures on heart rhythm during acute myocardial ischemia.
Electrostimulation of the central gray matter in the sylvian aqueduct and nucleus raphe magnus produced an antiarrhythmic effect during acute myocardial ischemia. Stimulation and blockade of opiate receptors in the central amygdaloid nucleus and lateral hypothalamus with dalargin and naloxone induced the same effect. Destruction of the central gray matter in the sylvian aqueduct and nucleus raphe magnus decreased electrical stability of ischemic myocardium.
Prokop'eva
E V
EV
Department of Pathophysiology, Irkutsk State Medical University. prokopyeva@ismu.baikal.ru
Pivovarov
Y I
YI
D000679:Amygdala / Q000473:pathology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D007031:Hypothalamus / Q000473:pathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D009292:Narcotic Antagonists; D009294:Narcotics; D012701:Serotonin; D009270:Naloxone; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-