title: Corneal ulcer caused by the new fungal species Sarcopodium oculorum.
abstract: We describe a case of keratitis caused by a new species of the hyphomycetous genus Sarcopodium, S. oculorum. The corneal ulcer developed after 5 months of treatment with corticosteroids in a Brazilian boy diagnosed with allergic conjunctivitis. Fungal hyphae and conidia were detected in corneal scrapings, and repeated cultures were positive for this fungus. The infection was resolved with natamycin and ketoconazole. Eleven antifungals were tested against this fungus, and all except flucytosine and fluconazole showed in vitro activity.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, 43201 Reus, Tarragona, Spain. umb@fmcs.urv.es
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Höfling-Lima
authors.forename: Josepa
authors.initials: J
authors.lastname: Gené
authors.forename: Denise
authors.initials: D
authors.lastname: De Freitas
authors.forename: Patricio
authors.initials: P
authors.lastname: Godoy
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Zorat-Yu
authors.forename: Luis
authors.initials: L
authors.lastname: Zaror
authors.forename: Olga
authors.initials: O
authors.lastname: Fischman
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D003320:Corneal Ulcer / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000382:microbiology*; D006801:Humans; D007634:Keratitis / Q000382:microbiology; D007654:Ketoconazole / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000145:classification* / Q000302:isolation & purification*; D009181:Mycoses / Q000382:microbiology*; D010866:Natamycin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D010866:Natamycin; D007654:Ketoconazole