title: [Pneumonia due to Legionella pneumophila in an immunocompromised child].
abstract: A one-year-and-seven-months-old boy was hospitalised because of fever, cough and general malaise. A diagnosed tonsillitis and pneumonia were treated with intravenous antibiotics. His clinical condition worsened despite antibiotic therapy. After immunologic investigations revealed both a cellular and a humoral immune disorder, a broncho-alveolar lavage was performed. The culture revealed Legionella pneumophila. Antibiotic treatment was then changed to erythromycin in combination with rifampicin, with a good response. Although rarely described in childhood, one should consider L. pneumophila as a possible pathogen in immunocompromised children presenting with pneumonia.
authors.affiliation: Afd. Algemene Pediatrie en Infectieziekten, Universitair Medisch Centrum, Wilhelmina Kinderziekenhuis, Postbus 85.090, 3508 GA Utrecht.
authors.forename: K
authors.initials: K
authors.lastname: van Dijk
authors.forename: S
authors.initials: S
authors.lastname: Kamphuis
authors.forename: S P M
authors.initials: SP
authors.lastname: Geelen
authors.forename: N M
authors.initials: NM
authors.lastname: Wulffraat
authors.forename: J P J
authors.initials: JP
authors.lastname: van Gestel
authors.forename: T F W
authors.initials: TF
authors.lastname: Wolfs
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D024841:Fluoroquinolones; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D016952:Legionella pneumophila / Q000302:isolation & purification; D007877:Legionnaires' Disease / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000188:drug therapy; D012293:Rifampin / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D024841:Fluoroquinolones; D004917:Erythromycin; D012293:Rifampin