1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands.
A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT(7) receptor ligands.
Isaac
Methvin B
MB
NPS Pharmaceuticals Inc., Mississauga, ON, Canada. misaac@npsp.com
Xin
Tao
T
O'Brien
Anne
A
St-Martin
David
D
Naismith
Angela
A
MacLean
Neil
N
Wilson
Julie
J
Demchyshyn
Lidia
L
Tehim
Ashok
A
Slassi
Abdelmalik
A
D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007211:Indoles; D008024:Ligands; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C104425:serotonin 7 receptor