[Pathogenesis of pre-eclampsia: role of gamma PPAR in trophoblast invasion].
Pre-eclampsia is a major complication of human pregnancy. Its trigger is from placental origin and may involve an abnormal placentation characterized by a defect of trophoblast invasion and an absence of remodelling of the maternal spiral arteries. In this study, we have characterized and developed a model of culture of extravillous trophoblast cells involved in human implantation. We showed that these cells expressed high levels of PPAR gamma by immunocytochemistry and real-time quantitative PCR. We showed that different natural ligands potentially present at the feto-maternal interface, such as oxidised low density lipoproteins, inhibited in vitro in a concentration dependent manner extravillous cytotrophoblast invasion. These results point to a key role of PPAR gamma in the pathology of pre-eclampsia.
Evain-Brion
Danièle
D
Institut National de la Santé et de la Recherche Médicale, U427, Université René Descartes, 4 avenue de l'Observatoire, 75006 Paris, France.
Fournier
Thierry
T
Therond
Patrice
P
Tarrade
Anne
A
Pavan
Laetitia
L
D005260:Female; D006801:Humans; D008024:Ligands; D011225:Pre-Eclampsia / Q000209:etiology* / Q000473:pathology; D011247:Pregnancy; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000502:physiology*; D014157:Transcription Factors / Q000096:biosynthesis / Q000502:physiology*; D014327:Trophoblasts / Q000378:metabolism* / Q000473:pathology
D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors