Prevention of gastric cancer by Helicobacter pylori eradication? Results from clinical intervention studies.
The incidence of gastric cancer is decreasing; however, in some parts of the world this malignancy is still the second most common cause of cancer-related deaths and recent epidemiological analysis indicates that approximately 1,000,000 individuals will die from gastric cancer every year. Therefore, finding potent mechanisms of cancer prevention is of great importance, since this disease is commonly diagnosed in advanced stages. This review will provide a short update on the mechanisms of gastric carcinogenesis and will present recent data obtained from first clinical intervention studies aimed at the prevention of gastric cancer by Helicobacter pylori eradication.
Schandl
Laslo
L
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University Magdeburg, Germany.
Malfertheiner
Peter
P
Ebert
Matthias P A
MP
D000818:Animals; D017209:Apoptosis; D002448:Cell Adhesion; D002455:Cell Division; D005753:Gastric Mucosa / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D013274:Stomach Neoplasms / Q000209:etiology / Q000517:prevention & control*