title: Plasma nitrotyrosine concentration relates to prognosis in human septic shock.
abstract: Interrelation of plasma nitrotyrosine (NT) concentrations in patients of septic shock and their prognosis was examined. Blood samples were obtained from 12 patients during the first episode of septic shock at hospitalization, and their plasma NT concentrations were measured. Five patients died within five days after hospitalization, but seven patients recovered. Plasma NT concentrations (means +/- SE) of the non-survivors and survivors were 0.68 +/- 0.13 nmol/mL (n = 7), and 0.21 +/- 0.05 nmol/mL (n = 5), respectively, the former being significantly higher than the latter. The present results suggest that plasma concentration of NT relates to prognosis in human septic shock, although further studies with a larger patient population are necessary for confirmation of the suggestion.
authors.affiliation: Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Munehiko
authors.initials: M
authors.lastname: Ohya
authors.forename: Seishiro
authors.initials: S
authors.lastname: Marukawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
authors.forename: Naoko
authors.initials: N
authors.lastname: Ueno
authors.forename: Katsushi
authors.initials: K
authors.lastname: Hosohara
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Terada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kosaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D016638:Critical Illness; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D011336:Probability; D011379:Prognosis; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D016019:Survival Analysis; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide; C002744:3-nitrotyrosine; D014443:Tyrosine