title: Effect of prenatal administration of haloperidol, risperidone, quetiapine and olanzapine on spatial learning and retention in adult rats.
abstract: The typical antipsychotic haloperidol and atypical antipsychotics olanzapine, quetiapine and risperidone were administered to pregnant Sprague-Dawley dams in the drinking water from Days 8 to 18 of gestation. When the offspring reached adulthood (2 months), spatial learning and short-term retention were examined using the radial arm maze. Results showed that prenatal administration of haloperidol, risperidone and quetiapine impaired learning but only haloperidol and risperidone disrupted short-term retention.
authors.affiliation: Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York 10001, USA. helenrosengarten@nyu.med.edu
authors.forename: Helen
authors.initials: H
authors.lastname: Rosengarten
authors.forename: David
authors.initials: D
authors.lastname: Quartermain
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003987:Dibenzothiazepines / Q000008:administration & dosage* / Q000378:metabolism; D004326:Drinking; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage* / Q000378:metabolism; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D000069348:Quetiapine Fumarate; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000378:metabolism; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology; D018967:Risperidone / Q000008:administration & dosage* / Q000378:metabolism; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D011954:Receptors, Dopamine; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D010890:Pirenzepine; D006220:Haloperidol; D018967:Risperidone; D000077152:Olanzapine