Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship.
In our endeavor to design and synthesize novel anticancer agents, a new series of indoloquinazoline compounds were prepared and tested initially for anticancer activity in vitro against a panel of human cancer cell lines. Most of these compounds exhibited cytotoxic activity in in vitro screens. Compounds were selected and further evaluated using a modified Hollow Fiber Assay for their preliminary in vivo activity against 12 cell lines implanted in the subcutaneous and intraperitoneal compartments in mice. The results indicate that these compounds may constitute a new class of anticancer agents.
Sharma
Vedula M
VM
Discovery Chemistry (Natural Products), Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India. sarmavm@drreddys.com
Prasanna
P
P
Seshu
K V Adi
KV
Renuka
B
B
Rao
C V Laxman
CV
Kumar
G Sunil
GS
Narasimhulu
C Prasad
CP
Babu
P Aravind
PA
Puranik
R C
RC
Subramanyam
D
D
Venkateswarlu
A
A
Rajagopal
Sriram
S
Kumar
K B Sunil
KB
Rao
C Seshagiri
CS
Mamidi
N V S Rao
NV
Deevi
Dhanvanthri S
DS
Ajaykumar
R
R
Rajagopalan
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000737:chemistry; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011799:Quinazolines / Q000737:chemistry; D013329:Structure-Activity Relationship; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles; D011799:Quinazolines; C475704:indolo(2,1-b)quinazoline; C046243:tryptanthrine