title: [P53 and P16 gene mutations in non-small cell lung cancer].
abstract: The aim of this study was to assess prospectively the occurrence of p53 and p16 mutations (considered separately and together) in NSCLC in terms of their clinical and prognostic relevance. Study group included 87 patients who underwent pulmonary resection for cure. p53 and p16 mutations were found in 22 (25%) and 14 (16%) cases, respectively. In eight patients (9%) both mutations were present, and the tendency for their common occurrence was significant (p = 0.02). There was no relation between mutation and clinical characteristics. Median survival in the entire group was 17 months and the 3-year survival probability--41%. There was no correlation between the occurrence of any mutation (considered separately or together) and survival. These results indicate that p53 and p16 gene mutations tend to occur together in NSCLC, however these alterations seem not to have noteworthy clinical and prognostic significance.
authors.affiliation: Klinika Chorób Płuc i Gruźlicy, AM w Gdańsku.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jassem
authors.forename: Rodryg
authors.initials: R
authors.lastname: Ramlau
authors.forename: Rafał
authors.initials: R
authors.lastname: Dziadziuszko
authors.forename: Amelia
authors.initials: A
authors.lastname: Szymanowska
authors.forename: Joanna
authors.initials: J
authors.lastname: Jakóbkiewicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lamperska
authors.forename: Grazyna
authors.initials: G
authors.lastname: Kobierska
authors.forename: Jan
authors.initials: J
authors.lastname: Skokowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Dyszkiewicz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mackiewicz
authors.forename: Maciej
authors.initials: M
authors.lastname: Zylicz
authors.forename: Jacek
authors.initials: J
authors.lastname: Jassem
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019942:Genes, p16; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate