Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy.
Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted influenza A/WSN/33 strain in pregnant mice. Viral RNA and nucleoprotein were detected in fetal brains and the viral RNA persisted for at least 90 days of postnatal life. We have, thus, obtained evidence for transplacental passage of influenza virus in mice and the persistence of viral components in the brains of these animals into young adulthood.
Aronsson
Fredrik
F
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Lannebo
Charlotta
C
Paucar
Martin
M
Brask
Johan
J
Kristensson
Krister
K
Karlsson
Håkan
H
D000818:Animals; D001921:Brain / Q000821:virology*; D001927:Brain Diseases / Q000821:virology*; D005260:Female; D018445:Infectious Disease Transmission, Vertical; D009980:Influenza A virus / Q000235:genetics / Q000302:isolation & purification*; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000150:complications* / Q000401:mortality / Q000635:transmission; D011247:Pregnancy; D012367:RNA, Viral / Q000032:analysis; D015996:Survival Rate
D012367:RNA, Viral