Alterations in acetylcholinesterase isoenzyme pattern of hippocampus after septal lesions in rat brain.
The effect of septal lesions upon the AChE (EC 3.1.1.7) isoenzymic pattern in the hippocampus of the rat brain was studied 1-3 months after surgery by means of polyacrylamide disc electrophoresis. Alterations in the isoenzymic pattern were found in the membrane-bound but not in the soluble fraction of the enzyme. In addition to the two slowly migrating bands seen in the membrane-bound AChE fraction of the normal hippocampus, the fast-migrating isoenzyme becomes visible.
Oderfeld-Nowak
B
B
Department of Biochemistry of Nervous System and Muscle, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Skangiel-Kramska
J
J
D000110:Acetylcholinesterase / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D006624:Hippocampus / Q000737:chemistry / Q000201:enzymology*; D007527:Isoenzymes / Q000032:analysis / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D020665:Septum of Brain / Q000502:physiology* / Q000601:surgery; D013995:Time
D007527:Isoenzymes; D000110:Acetylcholinesterase