A novel strategy for the synthesis of medium-sized lactams.
[reaction: see text] A novel method for the synthesis of medium-sized lactams based on an auxiliary-mediated combined tethered/templated strategy is presented. Cyclization by a tethered ring-closing metathesis reaction was followed by a templated transannular aminolysis reaction to give seven- to ten-membered lactams in good yields.
Bieräugel
Hans
H
Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, The Netherlands.
Jansen
T Paul
TP
Schoemaker
Hans E
HE
Hiemstra
Henk
H
van Maarseveen
Jan H
JH