Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer.
A very long half-life of paroxetine (195 h instead of the usual value of around 16 h) was measured after an overdose with 2 g paroxetine and 1 g clorazepate in a patient who was an extensive cytochrome P4502D6 metabolizer. The patient recovered well without any clinically significant complications. A consequence of the close monitoring of paroxetine levels in this patient was that it was decided not to reintroduce any other antidepressant despite her suicide attempt, until normal levels of paroxetine had been reached, which took over 1 month.
Hilleret
Henriette
H
University Department of Psychiatry, Belle-Idée, Chêne-Bourg, Geneva, Switzerland.
Voirol
Pierre
P
Bovier
Philippe
P
Giannakopoulos
Panteleimon
P
Zullino
Daniele
D
Baumann
Pierre
P
Giroud
Christian
C
Rivier
Laurent
L
Eap
Chin B
CB
D014151:Anti-Anxiety Agents / Q000378:metabolism* / Q000506:poisoning; D018687:Antidepressive Agents, Second-Generation / Q000378:metabolism* / Q000506:poisoning; D001007:Anxiety / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D003009:Clorazepate Dipotassium / Q000378:metabolism / Q000506:poisoning; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D004347:Drug Interactions; D062787:Drug Overdose; D005260:Female; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D017374:Paroxetine / Q000378:metabolism* / Q000506:poisoning; D013406:Suicide, Attempted
D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine; D003009:Clorazepate Dipotassium; D019389:Cytochrome P-450 CYP2D6