title: Antiplasmodial activity of labdanes from Aframomum latifolium and Aframomum sceptrum.
abstract: Bioguided fractionation of extracts of Aframomum latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-( S)-nerolidol and seven labdanes, coronarin B, galanal A and B, galanolactone, ( E)-8beta,17-epoxylabd-12-ene-15,16-dial, (+)-( E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact. The labdanes show a modest in vitro activity against a chloroquine-sensitive Plasmodium falciparum strain.
authors.forename: George
authors.initials: G
authors.lastname: Duker-Eshun
authors.forename: Jerzy W
authors.initials: JW
authors.lastname: Jaroszewski
authors.forename: William A
authors.initials: WA
authors.lastname: Asomaning
authors.forename: Francis
authors.initials: F
authors.lastname: Oppong-Boachie
authors.forename: Carl Erik
authors.initials: CE
authors.lastname: Olsen
authors.forename: S Brøgger
authors.initials: SB
authors.lastname: Christensen
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D010963:Plasmodium falciparum / Q000187:drug effects; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D004224:Diterpenes; C433017:labdane