title: Heart failure in patients admitted to hospital: mortality is still high.
abstract: BACKGROUND: Two separate cohorts of consecutive patients admitted to hospital with a primary diagnosis of heart failure were studied, the first in 1986 in Rochdale, and the second in 1995 in Brighton. METHODS: We observed the clinical profile, treatment and mortality during hospital admission and reviewed their status at 6 months. There were 132 patients in the Rochdale cohort and 223 in the Brighton cohort. RESULTS: The Rochdale cohort was characterised by a lower mean age and longer hospital stay. Significant differences were also observed in co-morbidity and the use of ACE inhibitors, but hospital mortality was almost identical (25% in Rochdale and 24% in Brighton). A low systolic blood pressure, hyponatraemia, hyperkalaemia and a raised blood urea at presentation were independent adverse prognostic factors. In contrast, prior treatment with ACE inhibitors in patients with congestive cardiac failure led to a more favourable hospital outcome. Age, gender and co-morbidity did not affect mortality apart from patients with acute myocardial infarction. Follow-up of these cohorts showed that mortality of the two groups remained high at 180 days after admission (40% in Rochdale and 39% in Brighton). There were marked differences in the use of ACE inhibitors in survivors, but target doses of ACE inhibitors (enalapril 20 mg/day or equivalent) were only achieved in 31%, despite direct communication between the hospital and primary care physicians. CONCLUSIONS: Although clinical and treatment profiles differed between the two periods studied, the hospital and 6-month mortality of patients with heart failure remained high. More emphasis needs to be given to optimising ACE inhibitor use in primary care.
authors.affiliation: University Department of Cardiovascular Medicine, City Hospital NHS Trust, Dudley Road, Birmingham, UK
authors.forename: P S.
authors.initials: PS
authors.lastname: Wong
authors.forename: G K.
authors.initials: GK
authors.lastname: Davidsson
authors.forename: J
authors.initials: J
authors.lastname: Timeyin
authors.forename: A
authors.initials: A
authors.lastname: Warren
authors.forename: D J.
authors.initials: DJ
authors.lastname: Watson
authors.forename: R
authors.initials: R
authors.lastname: Vincent
authors.forename: C
authors.initials: C
authors.lastname: Davidson