Theoretical modeling of oral absorption of barbiturates.
The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.
Ghafourian
Taravat
T
School of Pharmacy, Tabriz Medical Sciences University, Iran. ghafourt@tbzmed.ac.ir
Barzegar-Jalali
Mohammad
M
D000042:Absorption; D001463:Barbiturates / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D009061:Mouth Mucosa / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship
D001463:Barbiturates