title: The behavioral spectrum of tic disorders: a community-based study.
abstract: BACKGROUND
  Tourette syndrome (TS) and related tic disorders are commonly associated with obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD). It has been argued, however, that any observed association between TS and these and other psychopathologies may be due to ascertainment bias in that individuals with multiple problems are more likely to be referred for medical evaluation.
  
  
  METHODS
  In order to overcome the potential confounding by ascertainment bias, the authors conducted a community-based study of school children using direct interviews to determine the prevalence of tic disorders and any comorbid psychopathology. A standard psychiatric interview and standardized rating scales were utilized to diagnose childhood behavioral disorders.
  
  
  RESULTS
  Of the 1,596 children interviewed, 339 were identified as having tics. The following psychopathologies were found more commonly (p < 0.05) in the children with tics: OCD, ADHD, separation anxiety, overanxious disorder, simple phobia, social phobia, agoraphobia, mania, major depression, and oppositional defiant behavior.
  
  
  CONCLUSIONS
  The behavioral spectrum of tic disorders includes OCD, other anxiety disorders, a mood disorder, and attention-deficit and disruptive behavior disorders.
authors.affiliation: Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642-8673, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kurlan
authors.forename: P G
authors.initials: PG
authors.lastname: Como
authors.forename: B
authors.initials: B
authors.lastname: Miller
authors.forename: D
authors.initials: D
authors.lastname: Palumbo
authors.forename: C
authors.initials: C
authors.lastname: Deeley
authors.forename: E M
authors.initials: EM
authors.lastname: Andresen
authors.forename: S
authors.initials: S
authors.lastname: Eapen
authors.forename: M P
authors.initials: MP
authors.lastname: McDermott
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001526:Behavioral Symptoms / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D016009:Chi-Square Distribution; D002648:Child; D003625:Data Collection / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D016017:Odds Ratio; D013981:Tic Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D005879:Tourette Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology