Intratumoral fat in neurofibroma.
Three cases of a solitary neurofibroma showing focal fatty changes are reported. Fatty changes in a neurofibroma are rarely observed and have not been reported, and also, the pathogenesis of neurofibroma has not been clarified. We postulate that the fatty changes in a neurofibroma may be the result of so-called senescent change or chronic injury. The origin of adipose cells may be attributable to fatty infiltration from abutting tissues or to a metaplasia of tumor cells or resident fibroblasts.
Ahn
Sung Ku
SK
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea. ahnsk@wonju.yonsei.ac.kr
Ahn
Hyung Jin
HJ
Kim
Tae-Hyun
TH
Hwang
Sang Min
SM
Choi
Eung Ho
EH
Lee
Seung Hun
SH
D000273:Adipose Tissue / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009455:Neurofibroma / Q000737:chemistry / Q000209:etiology / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000209:etiology / Q000473:pathology*
D014408:Biomarkers, Tumor; D009418:S100 Proteins