Confirmation of a gene for multiple sclerosis (MS) to chromosome region 19q13.3.
To identify the chromosomal localizations of the multiple sclerosis (MS) genes, we conducted a genomewide linkage analysis using eighteen affected families. A MS gene is linked to markers located in the 19q13.3 region (multipoint lod-score = 2.1). Apolipoprotein E (ApoE) gene, located in this region, is an excellent candidate gene for MS because the ApoEe4 allele is acting as a severity allele in the disease.
Lucotte
G L
GL
Laboratory of Molecular Neurogenetics, Paris, France.
D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005602:France; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D010375:Pedigree
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers