title: [Analysis on polymorphism in exons 2,3 and 4 of the MICA gene in three different Chinese populations].
abstract: OBJECTIVE
  To detect genetic polymorphism in the exons 2 to 4 of the MICA gene in Chinese Han population in Shanghai, Dai population in Yunnan province and Uygur population in Xinjiang province respectively.
  
  
  METHODS
  DNA samples from 183 random healthy individuals in Han population, 41 in Dai population and 66 in Uygur population were genotyped by using the polymerase chain reaction (PCR) and sequence-specific oligonucleotide probing (SSOP) method.
  
  
  RESULTS
  In total, 10, 7 and 9 alleles of MICA were observed in Han, Dai and Uygur population respectively. MICA*008 was the most common allele in the population of both Han and Uygur, whereas MICA*010 was the most popular one in Dai population. Han and Dai had a bit similar distribution pattern (Chi-square=12.809  P=0.046), in contrast with Han to Uygur (Chi-square=58.499  P=0) and Dai to Uygur (Chi-square=49.273  P=0).
  
  
  CONCLUSIONS
  MICA gene displayed different allele distributions in different populations.
authors.affiliation: Shanghai Second Medical University, Shanghai Institute of Immunology, Shanghai,200025 P.R.China. Lian-Fan@online.sh.cn
authors.forename: Weijuan
authors.initials: W
authors.lastname: Gong
authors.forename: Li'an
authors.initials: L
authors.lastname: Fan
authors.forename: Jueqin
authors.initials: J
authors.lastname: Yang
authors.forename: Lingdi
authors.initials: L
authors.lastname: Xu
authors.forename: Fangjuan
authors.initials: F
authors.lastname: Yao
mesh_terms: D000483:Alleles; D002681:China; D005091:Exons / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D005843:Geography; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A