title: [Bladder choriocarcinoma: retrospective analysis of the de-differentiation of a transitional-cell papillary bladder carcinoma. Apropos of a case].
abstract: OBJECTIVE
  To report a case of choriocarcinoma of the bladder during the different periods of its evolution. The anatomopathological study showing dedifferentiation of a transitional cell tumor is presented and the histogenesis of this rare tumor is discussed.
  
  
  METHODS
  A case of a rapidly progressing transitional cell tumor of the bladder that dedifferentiated into choriocarcinoma is presented. The pathological findings of the first resections of the transitional cell tumor that progressed to choriocarcinoma are presented and the histogenesis is discussed.
  
  
  CONCLUSIONS
  Choriocarcinoma of the bladder is very rare, highly malignant and carries a poor prognosis. Its origin is widely accepted to be in the dedifferentiation of a transitional cell tumor. The use of immunohistochemistry and the positivity of HCG support the diagnosis.
authors.affiliation: Servicio de Urología, Hospital Universitario Juan Canalejo, La Coruña, España.
authors.forename: Enrique
authors.initials: E
authors.lastname: Fernández Rosado
authors.forename: Germán
authors.initials: G
authors.lastname: Suárez Pascual
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodríguez Gómez
authors.forename: Antonio
authors.initials: A
authors.lastname: Blanco Díez
authors.forename: Luis
authors.initials: L
authors.lastname: Alvarez Castelo
authors.forename: F
authors.initials: F
authors.lastname: Gomez Veiga
authors.forename: S
authors.initials: S
authors.lastname: Novas Castro
authors.forename: Marcelino
authors.initials: M
authors.lastname: González Martín
authors.forename: L
authors.initials: L
authors.lastname: Valbuena Rubira
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D002822:Choriocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000556:secondary; D006063:Chorionic Gonadotropin / Q000032:analysis; D015653:Cystectomy; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D011468:Prostatectomy; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014547:Urinary Diversion
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D009363:Neoplasm Proteins