Increased vulnerability of auditory system to noise exposure in mdx mice.
OBJECTIVE
Dystrophin is a cytoskeletal protein mainly found just beneath the sarcolemma. Lack of dystrophin is known to be the cause of Duchenne muscular dystrophy (DMD). Other tissues, including the brain, retina, and cochlear hair cells, also express dystrophin. Recently, a gene (Xp21.2) associated with sensorineural hearing impairment has been mapped within the localization site for dystrophin in two families. Thus, it is reasonable to assume that dystrophin may play a role in auditory function. However, animal studies have produced conflicting results.


METHODS
An attempt was made to clarify the differences between the auditory systems of dystrophin-deficient mdx mice and control B-10 mice by exposure to noise.


METHODS
In the present study, mdx mice and B-10 mice were used. Animals were exposed daily to noise for 1 month, and their auditory functions were evaluated by recording the brainstem auditory evoked potentials (BAEPs).


RESULTS
Before noise exposure, the mdx mouse demonstrated normal BAEP threshold when compared with the B-10 mouse. After 1 month of noise exposure, the B-10 mouse showed no apparent change in hearing threshold and BAEP latencies. In contrast, significantly increased hearing threshold and prolonged BAEP peak and interpeak latencies were observed in the mdx mouse after noise exposure.


CONCLUSIONS
These results indicate that the mdx mice are more vulnerable to noise damage. This involves not only the peripheral auditory system, but also the brainstem central auditory pathway. Therefore, a significant role for dystrophin in the auditory system, especially under noise stress, is suggested.
Chen
Tsan-Ju
TJ
Department of Physiology, Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan. tsanju@cc.kmu.edu.tw
Chen
Shun-Sheng
SS
Wang
Dean-Chuan
DC
Hsieh
Yueh-Ling
YL
D000704:Analysis of Variance; D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem; D006319:Hearing Loss, Sensorineural / Q000150:complications* / Q000503:physiopathology; D051379:Mice; D018101:Mice, Inbred mdx; D009137:Muscular Dystrophy, Animal / Q000150:complications* / Q000503:physiopathology; D009622:Noise / Q000009:adverse effects*; D018709:Statistics, Nonparametric