title: Studies on the efficacy of cholecalciferol and derivatives for stimulating phytate utilization in broilers.
abstract: Studies were conducted to determine the effect of dietary supplementation with cholecalciferol (D3), 1,25-dihydroxycholecalciferol [1,25-(OH)2D3], 1alpha-hydroxycholecalciferol (1alpha-OHD3), and 25-hydroxycholecalciferol (25-OHD3) on utilization of phytate P by broiler chickens. Three experiments were conducted with corn-soybean meal type diets with D3 and 1,25-(OH)2D3 being tested in one experiment and 1,25-(OH)2D3, 1alpha-OHD3, and 25-OHD3 being tested in two experiments of exactly the same design. In the first experiment, high levels of D3 (110 microg and 220 microg/kg of diet) increased phytate P utilization, but the increase was not as great as that obtained from 1,25-(OH)2D3 supplementation. In the other two experiments, 1,25-(OH)2D3, D3 and 1alpha-OHD3 were consistently effective in increasing phytate P utilization as measured by plasma Ca and P, incidence of P rickets, bone ash, and retention of Ca, P, and phytate P. Supplementation with 25-OHD3 in general gave smaller and more inconsistent responses to these criteria, indicating some inconsistency in its ability to improve phytate P utilization.
authors.affiliation: Department of Poultry Science, The University of Georgia, Athens 30602, USA. hedwards@arches.uga.edu
authors.forename: H M
authors.initials: HM
authors.lastname: Edwards
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight; D002112:Calcifediol / Q000494:pharmacology; D002117:Calcitriol / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D002645:Chickens / Q000378:metabolism*; D002762:Cholecalciferol / Q000494:pharmacology*; D004032:Diet; D019587:Dietary Supplements; D006887:Hydroxycholecalciferols / Q000494:pharmacology; D008297:Male; D010758:Phosphorus / Q000097:blood; D010833:Phytic Acid / Q000493:pharmacokinetics*; D013025:Glycine max; D003313:Zea mays
chemical_list: D006887:Hydroxycholecalciferols; D002762:Cholecalciferol; D010758:Phosphorus; D010833:Phytic Acid; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium; C008088:alfacalcidol