title: Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults.
abstract: An open-label, multicenter study was performed to assess bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults. Seventy aerobic (52.2%) and 64 anaerobic (47.8%) pathogens were recovered from clinically evaluable patients at baseline (before therapy). The most commonly isolated anaerobes were Prevotella species (31.1%), anaerobic streptococci (21.9%), and Fusobacterium species (15.6%). The aerobes most frequently recovered included Streptococcus species (21.4%), Haemophilus influenzae (15.7%), Pseudomonas aeruginosa (15.7%), and Staphylococcus aureus and Moraxella catarrhalis (10.0% each). Recurrences of signs or symptoms of bacterial maxillary sinusitis associated with anaerobes were twice as frequent as were those associated with aerobes when counts of anaerobes were > or =10(3) cfu/mL. A pathogenic role for Granulicatella species in cases of chronic sinusitis was documented for the first time.
authors.affiliation: Veterans Affairs Medical Center West Los Angeles, and University of California, Los Angeles, School of Medicine, CA 90073, USA. sidfinegol@aol.com
authors.forename: S M
authors.initials: SM
authors.lastname: Finegold
authors.forename: M J
authors.initials: MJ
authors.lastname: Flynn
authors.forename: F V
authors.initials: FV
authors.lastname: Rose
authors.forename: H
authors.initials: H
authors.lastname: Jousimies-Somer
authors.forename: C
authors.initials: C
authors.lastname: Jakielaszek
authors.forename: M
authors.initials: M
authors.lastname: McTeague
authors.forename: H M
authors.initials: HM
authors.lastname: Wexler
authors.forename: E
authors.initials: E
authors.lastname: Berkowitz
authors.forename: B
authors.initials: B
authors.lastname: Wynne
mesh_terms: D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D001420:Bacteria, Aerobic / Q000187:drug effects; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D015523:Maxillary Sinusitis / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination; D010400:Penicillin G