The prognostic value of pre-operative serum tetranectin, CA-125 and a combined index in women with primary ovarian cancer.
OBJECTIVE
To study the prognostic value of pre-operative serum tetranectin (TN), CA125 levels and a mathematical formula (Index1) in primary ovarian cancer.


METHODS
The study group consisted of sixty-six patients with varying FIGO stages I-IV. The end-point was death from ovarian cancer. Evaluation was by univariate life-tables analyses and the multivariate Cox analysis. In the Cox analyses, the variables were tested respectively in actual values and as dichotomy variables with different cut-off levels: 6.7, 7.3 and 8.2 mg/l for TN, 35, 65, 100 and 165 U/ml for CA125.


RESULTS
In stages I+II only CA125 was found to be significantly prognostic, whereas TN was of no prognostic value by univariate statistics. For stages III+IV patients significantly better survivals were found for patients with TN levels above the respective cut-offs compared to patients with low TN levels, whereas no significant value was found for CA125 by univariate statistics. In the Cox analyses, FIGO stage was the strongest and TN the second most prognostic variable, followed by age. CA125, Index1 and tumor types were of no prognostic value. The strongest prognostic value for TN was found at the cut-off level 8.2 mg/l (relative hazard for FIGO stages = 3.3 and for TN = 2.6).


CONCLUSIONS
TN was a strong prognostic variable in patients with advanced ovarian cancer. To the contrary, CA125 was a strong prognostic factor in patients with a localised ovarian cancer and of no prognostic value in patients with advanced cancer. The variables may be useful in the selection of patients with a poor outcome for new treatment strategies.
Høgdall
Claus K
CK
Department of Obstetrics and Gynecology, The Gynecologic Clinic, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Denmark. hogdall@dadlnet.dk
Nørgaard-Pedersen
Bent
B
Mogensen
Ole
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D037181:Lectins, C-Type; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D018394:CA-125 Antigen; D037181:Lectins, C-Type; C048648:tetranectin