Hypoglycaemia and lactic acidosis in a MALT non Hodgkin's lymphoma.
Hypoglycaemia associated with lactic acidosis is a rare complication of lymphomas; only four cases have been previously reported. Recent studies provide evidence of direct consumption of glucose by the tumour cells, leading to lactic acidosis. We report the case of a 64-year-old patient with a gastric diffuse large B cell non-Hodgkin's lymphoma transformed from an indolent mucosa associated lymphoid tissue (MALT) lymphoma, admitted to our department for acute renal failure due to a tumour lysis syndrome. After recovery from renal failure, she developed severe hypoglycaemia and lactic acidosis refractory to therapy. She died after the onset of shock and coma.
Di Comite
Gabriele
G
Department of Internal Medicine DIMER, IRCCS H. San Raffaele, Milan, Italy.
Dagna
Lorenzo
L
Piatti
Piero M
PM
Monti
Lucilla D
LD
Tantardini
Francesca
F
Praderio
Luisa
L
D000140:Acidosis, Lactic / Q000209:etiology*; D058186:Acute Kidney Injury / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000378:metabolism; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications* / Q000378:metabolism; D015275:Tumor Lysis Syndrome / Q000150:complications