title: BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.
abstract: BCL8 is a novel human gene family initially identified through cloning of BCL8A, located at the t(14;15)(q32;q11-q13) translocation breakpoint, in a case of diffuse large B-cell lymphoma. Multiple copies of BCL8A map to the 1-Mb proximal duplicated region at 15q. We identified additional copies on human chromosomes 13 (BCL8B), 22 (BCL8C), 2 (BCL8D), and 10 (BCL8E) by cDNA cloning and sequence analysis. BCL8A, BCL8C, BCL8D, and BCL8E are truncated at the genomic level and are presumably pseudogenes or sterile transcripts. BCL8B is expressed predominantly in human brain and encodes a 327-kDa protein with extensive homology to the Drosophila melanogaster protein kinase A anchoring protein RG. LRBA, a human gene with a ubiquitous expression pattern mapping to 4q32, encodes a protein closely related to BCL8. The phylogenetically conserved BCL8 gene family evolved by transchromosomal and intrachromosomal duplications within the human genome.
authors.affiliation: Cell Biology Program, Sloan-Kettering Institute and the Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
authors.forename: Vadim G
authors.initials: VG
authors.lastname: Dyomin
authors.forename: Seeta R
authors.initials: SR
authors.lastname: Chaganti
authors.forename: Katerina
authors.initials: K
authors.lastname: Dyomina
authors.forename: Nallasivam
authors.initials: N
authors.lastname: Palanisamy
authors.forename: Vundavalli V V S
authors.initials: VV
authors.lastname: Murty
authors.forename: Riccardo
authors.initials: R
authors.lastname: Dalla-Favera
authors.forename: R S K
authors.initials: RS
authors.lastname: Chaganti
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics; D017124:Conserved Sequence; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D018076:DNA, Complementary; D019143:Evolution, Molecular; D018628:Gene Dosage; D020440:Gene Duplication; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D018076:DNA, Complementary; C106193:NBEAP1 protein, human; D009363:Neoplasm Proteins; C428703:LRBA protein, human; D017868:Cyclic AMP-Dependent Protein Kinases