Effect of citalopram treatment on relationship between platelet serotonin functions and the Karolinska scales of personality in panic patients.
Using the Karolinska Scales of Personality (KSP), we investigated the effect of the selective serotonin reuptake inhibitor citalopram on personality traits and the relationship between personality traits and peripheral indexes for central serotonergic function in patients with panic disorder at baseline and after 6 months of treatment. The degree of anxiety and depression was assessed using the Beck Anxiety Inventory, the Beck Depression Inventory, the Clinical Anxiety Scale, and the Montgomery Asberg Depression Rating Scale. A reduction in anxiety and depression scores of 75% was observed after treatment in two thirds of the patients. Mean changes of 12% in the direction of normalization were observed in all KSP anxiety-related items (Somatic Anxiety, Muscular Tension, Psychic Anxiety, and Psychasthenia), the aggression and hostility related items (Inhibition of Aggression, Irritability, and Guilt) and the item of Socialisation. A positive correlation was found between Vmax for the platelet [14C]-serotonin uptake and Inhibition of Aggression before treatment, and a negative correlation was found between the affinity of serotonin uptake and Inhibition of Aggression after treatment. Negative childhood experiences influenced enhanced scores on some KSP items but not the serotonergic function. In panic patients treated with citalopram, effects were seen on personality traits, confirming an association between serotonergic activity and aggression.
Neuger
Jolanta
J
Karolinska Institute, Institution of Clinical Neuroscience, Department of Psychiatry, St. Göran's Hospital, Stockholm, Sweden. Jolanta.Neuger@spo.sll.se
Wistedt
Börje
B
Aberg-Wistedt
Anna
A
Stain-Malmgren
Rigmor
R
D000328:Adult; D000704:Analysis of Variance; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D015283:Citalopram / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology*; D010552:Personality Assessment / Q000706:statistics & numerical data; D010979:Platelet Function Tests / Q000706:statistics & numerical data; D012044:Regression Analysis; D012701:Serotonin / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D018709:Statistics, Nonparametric
D015283:Citalopram; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors