title: Objective assessment of photoageing effects using high-frequency ultrasound in PUVA-treated psoriasis patients.
abstract: BACKGROUND
  Skin ageing can be differentiated into intrinsic (chronological) ageing, and photoageing due to chronic sun exposure. Photoageing is the superimposition of photodamage on the ageing process.
  
  
  OBJECTIVE
  The aim of the study was to investigate possible differences between the skin of photochemotherapy (PUVA)-treated psoriasis patients and of untreated normal subjects using a high-frequency ultrasound system.
  
  
  METHODS
  A total of 124 volunteers (aged 21-88 years, median 52 years, 62 female, 62 male), 62 psoriasis patients who had received PUVA therapy and 62 healthy controls, were investigated. Skin thickness and a subepidermal low-echogenic band (SLEB), a parameter for photodamage, were measured in 12 different areas.
  
  
  RESULTS
  Female skin is thinner than male skin. The skin thickness values of PUVA patients were more markedly decreased than those of the controls for the older patients. There was a clear dependence of the occurrence of SLEB on PUVA therapy in psoriasis patients.
  
  
  CONCLUSIONS
  Long-term PUVA treatment in psoriasis patients accelerates thinning of the skin in comparison to age-matched controls. The results show that ultrasonography is a sensitive method to investigate the effects of PUVA-induced skin ageing.
authors.affiliation: Department of Special and Environmental Dermatology, University of Vienna, General Hospital, Währinger Gürtel 18-20, A-1090 Vienna, Austria. paul.sator@khl.magwien.gv.at
authors.forename: P-G
authors.initials: PG
authors.lastname: Sator
authors.forename: J B
authors.initials: JB
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Hönigsmann
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy / Q000473:pathology*; D012044:Regression Analysis; D012189:Retrospective Studies; D017678:Sex Distribution; D012867:Skin / Q000000981:diagnostic imaging* / Q000473:pathology; D015595:Skin Aging; D013997:Time Factors; D014463:Ultrasonography