Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats.
The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously fed with cholesterol (25 mg/kg b.w.) for 30 days caused lowering in the lipids and apoprotein levels of VLDL and LDL in experimental animals. The LLA of this drug is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acids excretion and enhanced plasma lecithin: cholesterol acyltransferase activity.
Khanna
A K
AK
Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India.
Rizvi
F
F
Chander
R
R
D000284:Administration, Oral; D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol; D005243:Feces / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D029803:Phyllanthus; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats
D001647:Bile Acids and Salts; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D002784:Cholesterol