T-bet and mucosal Th1 responses in the gastrointestinal tract.
T cells play an essential role in regulating mucosal immune responses in the gastrointestinal tract. Recent observations on T helper cell differentiation and activation by regulatory transcription factors-especially T-bet-in chronic inflammatory diseases have provided new perspectives for understanding mucosal immunity. Here we summarise recent advances in the field of transcription factors and discuss the implications of these findings for future therapeutic approaches in inflammatory bowel diseases. In particular, we have focused on the role of T-bet in controlling mucosal Th1 responses in the gastrointestinal tract.
Weigmann
B
B
Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany.
Neurath
M F
MF
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004064:Digestive System / Q000276:immunology*; D005753:Gastric Mucosa / Q000276:immunology; D015870:Gene Expression; D006801:Humans; D007111:Immunity, Cellular; D018928:Immunity, Mucosal; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology; D051379:Mice; D020825:T-Box Domain Proteins; D018417:Th1 Cells / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology*; D014158:Transcription, Genetic / Q000276:immunology; D000098815:T-bet Transcription Factor
D016207:Cytokines; D007375:Interleukin-1; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014157:Transcription Factors; D007371:Interferon-gamma