[Comparative study between midazolam and diazepam in upper gastrointestinal endoscopy premedication].
A prospective study evaluated and compared midazolam versus diazepam in the upper gastrointestinal endoscopy. Patients were excluded if they had experienced any of the following: intolerance to benzodiazepines, pregnancy, alcohol or drug addiction, and weakness chronic disease. Seventy one patients were assigned to two groups: 36 received diazepam (0,15 Mg/Kg. intravenous) and 35 midazolam (0,07 mg/kg.). Patients in the two study group were similar in regard to demographic data (sex, age, and weight). Midazolam resulted in a marked improvement of conscious sedation and the anxiolysis as compared with the group receiving diazepam (p<0.001). Amnesia were significantly more frequent in the midazolam group (total 77,14% and partial 17,14%) compared with diazepam group (total 11,11% and partial 2,77%). The present study show that midazolam improves patient tolerance lo endoscopy compared with diazepam (p<0.001).The selection of patients is very important, no clinically adverse events related to cardiopulmonary changes ocurred in any group.
Frisancho Velarde
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O
Departamento de Enfermedades del Aparato Digestivo, Hospital Nacional Edgardo Rabagliati Martins, Perú.
Contardo Zambrano
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C
D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D016292:Procedural Sedation; D003975:Diazepam / Q000494:pharmacology; D004384:Duodenoscopy; D005260:Female; D005773:Gastroscopy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D018579:Patient Selection; D011292:Premedication; D012119:Respiration / Q000187:drug effects
D018712:Analgesics, Non-Narcotic; D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D003975:Diazepam; D008874:Midazolam