[Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis].
OBJECTIVE
To evaluate further the nature of HLA-DQB1 alleles association with dermatomyositis/polymyositis (DM/PM).


METHODS
HLA-DQB1 typing of 52 patients with DM/PM were investigated by polymerase chain reaction-sequence  specific primer method, and the frequencies of HLA-DQB1 alleles were compared.


RESULTS
It was found that the patients with DM/PM had significantly increased frequency of HLA-DQB1*0401(RR=3.56, P=1.79  10(-3), Pc<0.05).


CONCLUSIONS
The results suggest that HLA-DQB1*0401 gene contribute to genetic susceptibility to DM/PM.
Han
Xiuping
X
Department of Dermatology, the First Hospital, China Medical University, Shenyang, Liaoning, 110001 P.R.China. nzhai@sina.com
Zhai
Ning
N
Zhang
Qingrui
Q
Li
Jiuhong
J
Liu
Jifeng
J
Du
Juan
J
Song
Fangji
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D003882:Dermatomyositis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen