title: Insulin-like growth factor-II induces hypertrophy of adult cardiomyocytes via two alternative pathways.
abstract: Insulin-like growth factor (IGF)-II is known to induce hypertrophy of isolated adult rat ventricular cardiomyocytes cultured in the absence of serum. However, it is not known how the growth factor exerts this hypertrophic effect. We show here that IGF-II induces hypertrophy of the cultured cardiomyocytes via two alternative pathways: (1) an IGF-I receptor-dependent pathway, or (2) a lysosome-dependent pathway when the IGF-I receptor-dependent pathway is blocked.
authors.affiliation: Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
authors.forename: Ling-Yang
authors.initials: LY
authors.lastname: Hao
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Buetow
mesh_terms: D000818:Animals; D000906:Antibodies; D006332:Cardiomegaly / Q000378:metabolism*; D002478:Cells, Cultured; D007335:Insulin-Like Growth Factor II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017526:Receptor, IGF Type 1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D000906:Antibodies; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1