Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.
OBJECTIVE
To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA).


METHODS
Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls.


RESULTS
None of the polymorphisms investigated showed any statistically significant associations with JIA.


CONCLUSIONS
The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.
Donn
R P
RP
Arthritis Research Campaign Epidemiology Unit (ARC/EU), Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Farhan
A
A
Stevans
A
A
Ramanan
A
A
Ollier
W E R
WE
Thomson
W
W
D000293:Adolescent; D000483:Alleles; D001141:Aromatase / Q000235:genetics; D001171:Arthritis, Juvenile / Q000235:genetics*; D002648:Child; D003346:Corticotropin-Releasing Hormone / Q000235:genetics; D047628:Estrogen Receptor alpha; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D018895:Microsatellite Repeats; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011110:Polymorphism, Genetic; D011388:Prolactin / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics; D012016:Reference Values; D014156:Transcortin / Q000235:genetics; D006113:United Kingdom; D044465:White People / Q000235:genetics
D047628:Estrogen Receptor alpha; D005819:Genetic Markers; D011960:Receptors, Estrogen; D011388:Prolactin; D014156:Transcortin; D003346:Corticotropin-Releasing Hormone; D001141:Aromatase