title: [Systemic sclerosis and pregnancy].
abstract: OBJECTIVE
  Pregnancy in a patient with systemic sclerosis (SSc) may pose a double problem to the medical team: influence of SSc on pregnancy and consequences of pregnancy to SSc manifestations.
  
  
  BACKGROUND
  Concepts have evolved. SSc was considered for a long time not only as not very propitious for pregnancy but also as a strict contraindication for procreation because risks for the mother and the baby were thought to be major. Currently, fertility is thought to be normal. Miscarriages and small-for-gestation age infants rate do not seem to be higher in SSc. Maternal and perinatal mortality is also not higher in SSc without severe visceral manifestations, i.e. without either pulmonary hypertension, or cardiac or respiratory insufficiency. Conversely, there is a significantly higher frequency of premature infants in SSc. As regards influence of pregnancy on SSc, the greatest fear is the occurrence of renal crisis, which may be life threatening for both mother and child. Each elevation of blood pressure, even if this increase is mild, should be considered as potentially very serious. However, pregnancy itself does not seem to increase the risk of renal crisis. Consequences of pregnancy to SSc manifestations are various but usually mild.
  
  
  CONCLUSIONS
  SSc is not a strict contraindication for pregnancy only if severe organ involvement, diffuse subset of SSc or recent onset of the disease has been ruled out. Physicians should be aware of specific problems, which SSc is possibly posing during pregnancy. Finally, it has been recently suggested that pregnancies could be involved in the pathogenesis of SSc through persisting microchimerism of fetal origin.
authors.affiliation: Service de médecine interne, hôpital Claude-Huriez, CHRU Lille, rue Michel-Polonovski, 59037 Lille, France. dlaunay@caramail.com
authors.forename: D
authors.initials: D
authors.lastname: Launay
authors.forename: M
authors.initials: M
authors.lastname: Hebbar
authors.forename: A S
authors.initials: AS
authors.lastname: Valat
authors.forename: A S
authors.initials: AS
authors.lastname: Ducloy
authors.forename: E
authors.initials: E
authors.lastname: Hachulla
authors.forename: P Y
authors.initials: PY
authors.lastname: Hatron
authors.forename: T
authors.initials: T
authors.lastname: Ouk
authors.forename: B
authors.initials: B
authors.lastname: Devulder
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007247:Infertility, Female / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012595:Scleroderma, Systemic / Q000150:complications*; D012720:Severity of Illness Index