title: Familial aggregation of uterine myomas in Japanese women.
abstract: To assess the familial aggregation of uterine myomas in Japanese women with myomas, one hundred forty four women requiring surgery for myomas and 288 age-matched healthy controls were studied in Hokkaido, Japan. The incidence of positive first-degree family history of myomas among women aged 45-54 years with myomas was greater than that among controls (31.5% versus 15.2%, respectively, p < 0.01). Analyses categorized by the status of parity and familiality among subjects showed that the risk for myomas was the greatest in women who had both fewer births (parity = 0 or 1) and the positive family history of myomas as compared with those who had both more births (parity > or = 2) and the negative familiality of myomas (odds ratio = 5.8, 95% confidence interval = 2.3 - 14.6). The results of this study suggest that Japanese middle-aged women with myomas have the familial predisposition of uterine myomas. Furthermore, nulliparous women with the familial aggregation of myomas may be at increased risk of the disease.
authors.affiliation: Department of Public Health, School of Medicine, Sapporo Medical University, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Sato
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Mori
authors.forename: Motoi
authors.initials: M
authors.lastname: Nishi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kudo
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Miyake
mesh_terms: D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D007889:Leiomyoma / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D010298:Parity; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000235:genetics*