title: Detection of flat lesions in the colon with CT colonography.
abstract: BACKGROUND
  We investigated whether flat lesions of the colon could be detected on computed tomographic colonography (CTC).
  
  
  METHODS
  CTC and conventional colonoscopy were performed on 547 consecutive patients. A subset of 22 polyps was described as flat on colonoscopy (n = 16) or CTC (n = 6) and are the basis of this report. CTC was performed with a standard technique (5-mm collimation, 3-mm reconstruction intervals). Patients were scanned in supine and prone positions. Examinations were randomly assigned and reviewed in a blinded fashion by two of three radiologists. Prospective interpretations were recorded. All patients had conventional colonoscopy, which served as the gold standard.
  
  
  RESULTS
  Twenty-two flat lesions ranging from 0.4 to 3.5 cm were histologically classified as adenomatous (n = 8) or hyperplastic (n = 14). The sensitivities for detecting all flat lesions and flat adenomas by each reviewer were 43% and 100%, 65% and 100%, and 15% and 13%, respectively. "Double reading" resulted in detection of 68% of all lesions and 100% of adenomas. Of the seven hyperplastic polyps missed by both reviewers, four were identified retrospectively.
  
  
  CONCLUSIONS
  Flat lesions of the colon represent an important source of false negative CTC examinations. Awareness of their morphology can assist radiologists in finding most of these challenging lesions.
authors.affiliation: Department of Radiology, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Fidler
authors.forename: C D
authors.initials: CD
authors.lastname: Johnson
authors.forename: R L
authors.initials: RL
authors.lastname: MacCarty
authors.forename: T J
authors.initials: TJ
authors.lastname: Welch
authors.forename: A K
authors.initials: AK
authors.lastname: Hara
authors.forename: W S
authors.initials: WS
authors.lastname: Harmsen
mesh_terms: D018256:Adenomatous Polyps / Q000000981:diagnostic imaging*; D000368:Aged; D003106:Colon / Q000000981:diagnostic imaging* / Q000473:pathology*; D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged