title: Potential impact of in situ liver splitting on the number of available grafts.
abstract: BACKGROUND
  The potential increase in the number of liver grafts gained from systematically using the technique of splitting optimal organs is still unknown. This study investigates the proportion of donors that should be considered for in situ split-liver harvesting according to strict criteria on which a consensus could be reached easily.
  
  
  METHODS
  The records of 407 consecutive donors during a 4-year period in Switzerland were analyzed. Non-heart-beating donors and donors with missing data were excluded, leaving 338 donors as the study population. Liver splitting was considered feasible when the following criteria were met: age> or =14 and < or =50 years; weight> or =45 kg; body mass index< or =26 kg/m2; intensive care stay< or =3 days; mean arterial pressure> or =60 mm Hg; Na< or =160 mmol/L; serum glutamic pyruvic transaminase< or =60 U/L; gamma-glutamyl transpeptidase< or =50 U/L; no steatosis at ultrasonography. Organs from donors> or =70 kg were considered suitable for a split, producing organs for two adults.
  
  
  RESULTS
  Fifty-two (15%) donors fulfilled all the conditions for a split-liver procedure, of whom 29 (8.6%) were donors for 2 adults. The number of donors suitable for splitting increased to 145 (43%) if donors with only one missing criterion were included (77 [23%] for 2 adults).
  
  
  CONCLUSIONS
  Even if the technique is restricted to optimal donors, splitting could appreciably increase the number of liver grafts. A wider use of the technique could reduce the patient's time on the waiting list and the need for living-donor procedures, and should be encouraged.
authors.affiliation: Transplantation Unit, Clinic of Digestive and Transplantation Surgery, University Hospitals, Geneva, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Toso
authors.forename: Frederic
authors.initials: F
authors.lastname: Ris
authors.forename: Gilles
authors.initials: G
authors.lastname: Mentha
authors.forename: Jose
authors.initials: J
authors.lastname: Oberholzer
authors.forename: Philippe
authors.initials: P
authors.lastname: Morel
authors.forename: Pietro
authors.initials: P
authors.lastname: Majno
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors