Localization of [14C]clarithromycin in rat gastric tissue when administered with lansoprazole and amoxicillin.
After oral and intravenous administration of [14C]clarithromycin to rats, c. 60-70% of the radioactivity in the gastric tissue was found to be distributed in the mucosal layer. Co-administration of lansoprazole and amoxicillin had no apparent effect on this distribution pattern of [14C]clarithromycin. The amount of unchanged [14C]clarithromycin in gastric contents increased with co-administration of lansoprazole and amoxicillin. Microautoradiograms of the gastric mucosa showed that [14C]clarithromycin was highly distributed in the mucous layer and in surface epithelial cells following oral administration. Homogeneous distribution of radioactivity was evident in the fundic gland. With iv administration, [14C]clarithromycin seemed to be secreted by both secreting cells in the gland base and surface epithelial cells.
Endo
H
H
Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403 Yoshino-cho 1-chome, Saitama-shi, Saitama 330-8530, Japan. hiromi.endou@po.rd.taisho.co.jp
Yoshida
H
H
Ohmi
N
N
Ohta
K
K
Higuchi
S
S
Suga
T
T
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism; D017291:Clarithromycin / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics; D004347:Drug Interactions / Q000502:physiology; D005753:Gastric Mucosa / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D007441:Intubation, Gastrointestinal; D064747:Lansoprazole; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000737:chemistry / Q000187:drug effects
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002250:Carbon Radioisotopes; D064747:Lansoprazole; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole