title: Reversing antibiotic resistance.
abstract: Over the past decade many well-tried chemotherapeutic agents have lost their effectiveness. This is due to a phenomenon referred to as multi-drug resistance. The most likely cause of multi-drug resistance is an increase in the activity of an efflux pump mediated through the actions of a P-glycoprotein. There is a continuing search, not only for new chemotherapeutic agents, but also for agents that can reverse the acquired resistance to existing agents.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Hodgkinson
authors.forename: Derek
authors.initials: D
authors.lastname: Sharples
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D002986:Clinical Trials as Topic; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D019450:Genes, MDR; D006801:Humans; D013629:Tamoxifen / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000900:Anti-Bacterial Agents; D013629:Tamoxifen