Evidence that the ratio of donor kidney weight to recipient body weight, donor age, and episodes of acute rejection correlate independently with live-donor graft function.
BACKGROUND
We demonstrated that higher donor kidney weight-to-recipient body weight (KW/BW) ratio showed better graft function in acute rejection-free renal recipients.


METHODS
We investigated the impacts of KW/BW ratios on the graft function including acute rejection and donor's age in 259 live-donor renal recipients. Renal parameters were measured yearly. Correlations between the variables and each parameter were assessed by mixed regression and analysis of variance.


RESULTS
Renal function showed a positive correlation with the KW/BW ratio, but an inverse correlation with the rejection episodes and donor's age. The regression slope for serum creatinine or creatinine clearance by these covariants was consistent each year. On comparing the lower KW/BW ratios (<3.0) with higher ratios (> or =4.5), the higher was associated with better graft function. Increased donor's age was associated with worse graft function.


CONCLUSIONS
KW/BW ratio, donor's age, and the number of acute rejections are independent covariants for graft function.
Seun Kim
Yu
Y
Departments of Surgery, Internal Medicine, Biostatistics, and the BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. yukim@yumc.yonsei.ac.kr.
Soo Kim
Myoung
M
Suk Han
Dae
D
Kee Kim
Dong
D
Min Myoung
Sung
S
Il Kim
Soon
S
Park
Kiil
K
D000328:Adult; D000367:Age Factors; D001835:Body Weight; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology / Q000503:physiopathology*; D016030:Kidney Transplantation; D008297:Male; D009929:Organ Size; D015996:Survival Rate; D014019:Tissue Donors
D003404:Creatinine