title: Influence of chemical structure of amphiphilic beta-cyclodextrins on their ability to form stable nanoparticles.
abstract: The aim of the study was to establish a correlation between the chemical structure of amphiphilic beta-cyclodextrins (beta-CDa) and their ability to form stable nanospheres. Amphiphilic derivatives were obtained according to an optimized well-known three-step synthesis. The selective acylation of the secondary face of beta-CD being well controlled, several beta-CDa presenting different substitution degree were synthesized. The self-organization properties of the derivatives were evaluated. The peracylated beta-CD, i.e. bearing 14 alkyl chains on the secondary hydroxyl groups, does not yield stable nanosphere suspension, even in the presence of a non ionic surfactant in the aqueous phase. However, the presence of partially acylated derivatives within the beta-CDa allows self-assembly into stable nanosphere suspension.
authors.affiliation: Département de Pharmacochimie Moléculaire, UMR CNRS 5063, UFR Pharmacie, Université Joseph Fourier-Grenoble I, 5 av. de Verdun, F 38243 Cedex, Meylan, France.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Gèze
authors.forename: Soad
authors.initials: S
authors.lastname: Aous
authors.forename: Isabelle
authors.initials: I
authors.lastname: Baussanne
authors.forename: JeanLuc
authors.initials: J
authors.lastname: Putaux
authors.forename: Jacques
authors.initials: J
authors.lastname: Defaye
authors.forename: Denis
authors.initials: D
authors.lastname: Wouessidjewe
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004339:Drug Compounding; D009682:Magnetic Resonance Spectroscopy; D008854:Microscopy, Electron; D008863:Microspheres; D010316:Particle Size; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D047392:beta-Cyclodextrins; C031215:betadex