NO-ergic mechanisms are implicated in a disturbed cardiac rhythm after systemic application of lipopolysaccharide E. coli to rats.
In acute experiments on nembutal-urethan-anaesthetized rats, a slow infusion of subseptic dose of lipopolysaccharide (LPS) Escherichia coli (1 mg/ml) via the right jugular vein immediately led to bradycardia and extrasystoles. Preliminary administration of 20 mg/kg N(G)-nitro-L-arginine methyl ester (L-NAME) or 30 mg/kg aminoguanidine hydrochloride prevented the LPS-induced extrasystoles but did not affect the pattern of bradycardia. We conclude that nitric oxide (NO)-ergic mechanisms are involved in provoking electrical instability of the heart in conditions of endotoxemia.
Koulchitsky
Stanislav V
SV
Institute of Physiology, National Academy of Sciences, Minsk, Belarus. stas@fizio.bas-net.by
Subbotin
Oleg V
OV
Azev
Oleg A
OA
Kulchitsky
Vladimir A
VA
D000818:Animals; D001919:Bradycardia / Q000139:chemically induced; D005117:Cardiac Complexes, Premature / Q000139:chemically induced / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004926:Escherichia coli; D006146:Guanidines / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology*; D007275:Injections, Intravenous; D007601:Jugular Veins; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D004791:Enzyme Inhibitors; D006146:Guanidines; D008070:Lipopolysaccharides; D009569:Nitric Oxide; C004479:pimagedine; D019331:NG-Nitroarginine Methyl Ester