Synthesis of [5-(4-pyrrol-1-yl-benzoyl)-1 H-pyrrol-2-yl)]-acetic acid and in vitro study of its inhibitory activity on aldose reductase enzyme and on protein glycation.
[5-(4-Pyrrol-1-yl-benzoyl)-1H-pyrrol-2-yl)]-acetic acid was synthesized in a Vilsmeier-Haack process and by other methods. The compound was found to inhibit the enzyme aldose reductase as well as the glycation process of proteins and could therefore be useful for the treatment of various pathological conditions.
Anagnostou
C
C
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece.
Nicolaou
I
I
Demopoulos
V J
VJ
D000085:Acetates / Q000494:pharmacology*; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D007202:Indicators and Reagents; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D011506:Proteins / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C464619:(5-(4-pyrrol-1-yl-benzoyl)-1 H-pyrrol-2-yl)acetic acid; D000085:Acetates; D004791:Enzyme Inhibitors; D017127:Glycation End Products, Advanced; D007202:Indicators and Reagents; D011506:Proteins; D011758:Pyrroles; D012710:Serum Albumin, Bovine; D000449:Aldehyde Reductase