title: Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction.
abstract: Aged Wistar rats are characterized by leptin and insulin resistance. The expression of SOCS-3 in hypothalamus increases with ageing. Food restriction during 3 months decreases obesity Lee index in aged rats with respect to their ad libitum aged-mates and brings serum leptin concentrations to values close to those of young rats. Food restriction partially reverts the increases in SOCS-3 mRNA levels associated with ageing. These results suggest that SOCS-3 may be a mediator of hypothalamic leptin resistance in the aged Wistar rat and that the hyperleptinemia associated with ageing is, at least in part, responsible for the increase of SOCS-3 expression in hypothalamus.
authors.affiliation: Faculty of Environmental Sciences, Regional Center of Biomedical Research, University of Castilla-La Mancha, Toledo, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Peralta
authors.forename: J M
authors.initials: JM
authors.lastname: Carrascosa
authors.forename: N
authors.initials: N
authors.lastname: Gallardo
authors.forename: M
authors.initials: M
authors.lastname: Ros
authors.forename: C
authors.initials: C
authors.lastname: Arribas
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D005508:Food Deprivation; D007031:Hypothalamus / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D008297:Male; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012097:Repressor Proteins; D015398:Signal Transduction / Q000502:physiology; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D014157:Transcription Factors
chemical_list: D020738:Leptin; D011506:Proteins; D012097:Repressor Proteins; C491410:Socs3 protein, rat; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D014157:Transcription Factors