title: Hypotension, renal failure, and pulmonary complications in leptospirosis.
abstract: During a recent outbreak of leptospirosis in northeastern Thailand, 148 patients with serologically diagnosed leptospirosis were seen in Loei hospital. The common serotypes were L. pyrogenes, and L. sejroe. Hypotension with a mean arterial pressure less than 70 mmHg upon admission or within 24 h after admission was observed in 94 patients or 64%. 30 patients had normal renal function; 30 patients had prerenal azotemia with mild pulmonary complication in 2; and 34 patients had acute renal failure. 29 patients with acute renal failure had pulmonary complications including pulmonary hemorrhage in 8, pulmonary edema in 3, acute respiratory distress syndrome (ARDS) in 14 and interstitial pneumonitis in 4. 54 patients had normal blood pressure. In this group 5 patients had acute renal failure; 16 had prerenal azotemia and 33 had normal renal function. Interstitial pneumonitis was noted in one patient with prerenal azotemia. Less renal complication and minimal pulmonary complication were seen in leptospirosis patients with normal blood pressure. The patients with normal renal function had no pulmonary complication. Good association existed between hypotension, renal failure and pulmonary complications.
authors.affiliation: Department of Medicine, Loei Hospital, Thailand.
authors.forename: Kannika
authors.initials: K
authors.lastname: Niwattayakul
authors.forename: Janthira
authors.initials: J
authors.lastname: Homvijitkul
authors.forename: Surachai
authors.initials: S
authors.lastname: Niwattayakul
authors.forename: Orawan
authors.initials: O
authors.lastname: Khow
authors.forename: Visith
authors.initials: V
authors.lastname: Sitprija
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D001806:Blood Urea Nitrogen; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D007022:Hypotension / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D007922:Leptospirosis / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D008171:Lung Diseases / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016019:Survival Analysis; D013785:Thailand / Q000453:epidemiology; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014511:Uremia / Q000209:etiology / Q000401:mortality / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D003404:Creatinine