In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.
Some quassinoids (1-6) isolated previously as plant growth inhibitors from the leaves of Eurycoma longifolia Jack. (Simaroubaceae) were subjected to in vitro tests on anti-tumor promoting, antischistosomal and plasmodicidal activities. The most active compound for inhibition of tumor promoter-induced Epstein-Barr virus activation (anti-tumor promotion) was 14,15beta-dihydroxyklaineanone (5, IC(50) = 5 microM). Longilactone (1) gave significant antischistosomal effect at a concentration of 200 microg/ml. 11-Dehydroklaineanone (3) and 15beta-O-acetyl-14-hydroxyklaineanone (6) showed potent plasmodicidal activity (IC(50) = 2 microg/ml). Thus it was suggested that E. longifolia possesses high medicinal values due to the occurrence of a variety of quassinoids.
Jiwajinda
Suratwadee
S
Central Laboratory and Greenhouse Complex, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand. rdiswj@nontri.ku.ac.th
Santisopasri
Vilai
V
Murakami
Akira
A
Sugiyama
Hiromu
H
Gasquet
Monique
M
Riad
Elias
E
Balansard
Guy
G
Ohigashi
Hajime
H
D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D001210:Asia, Southeastern; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D035701:Eurycoma / Q000737:chemistry*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D036702:Quassins / Q000737:chemistry / Q000494:pharmacology*; D012556:Schistosomicides / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects
D016588:Anticarcinogenic Agents; D000962:Antimalarials; D010936:Plant Extracts; D036702:Quassins; D012556:Schistosomicides