Membrane transport: a coat for ubiquitin.
Lysosomally directed receptors are concentrated at a 'bilayered' clathrin coat on the face of sorting endosomes. This coat is highly enriched in Hrs protein, which can potentially serve as an adaptor between ubiquitinated receptors and clathrin.
Clague
Michael J
MJ
Physiological Laboratory, University of Liverpool, Crown Street, L69 3BX, Liverpool, UK. clague@liv.ac.uk
D000818:Animals; D011992:Endosomes / Q000502:physiology; D008247:Lysosomes / Q000502:physiology; D026901:Membrane Transport Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D026901:Membrane Transport Proteins; D025801:Ubiquitin