Synthesis and antioxidative properties of novel thiazolidinedione/imidazolidinedione compounds as retinoids.
The general term "retinoids" refers to both naturally occurring as well as synthetic compounds which exhibit biological activity similar to vitamin A (retinol). Vitamin A and its two metabolites, retinaldehyde and retinoic acid, are fat-soluble unsaturated isoprenoids necessary for the growth, differentiation and maintenance of epithelial tissues. In this study, we have synthesized thiazolidinedione/imidazolidinedione compounds as retinoids. Their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels and superoxide anion formation were determined.
Dundar
B
B
Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Tandogan, Ankara, Turkey.
Bozdag-Dundar
O
O
Can-Eke
B
B
Coban
T
T
Iscan
M
M
Buyukbingol
E
E
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D003574:Cytochrome c Group / Q000737:chemistry; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D051381:Rats; D012176:Retinoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000975:Antioxidants; D003574:Cytochrome c Group; D007202:Indicators and Reagents; D012176:Retinoids; D013844:Thiazoles; D013481:Superoxides; D009249:NADP