Biodegradation and drug release studies of BSA loaded gelatin microspheres.
Certain variations in the process parameters (emulsification time, surfactant concentration) were performed in order to prepare BSA-loaded gelatin microspheres with high loading efficacy and particle size ranging from 1 to 10 microm using a procedure originally employed by Tabata and Ikada. The mathematical modelling of drug release in the presence of collagenase showed a biphasic release pattern, where the rate constant for the initial time release confirmed the influence of the particle size and/or enzymatic degradation rate on drug release rate.
Mladenovska
K
K
Institute of Pharmaceutical Technology, Department of Biopharmacy, Faculty of Pharmacy, University Ss Cyril and Methodious, Vodnjanska 17, 1000, Skopje, Macedonia.
Kumbaradzi
E
E
Dodov
G
G
Makraduli
L
L
Goracinova
K
K
D017364:Collagenases / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions; D005079:Excipients; D005780:Gelatin; D005976:Glutaral / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D008962:Models, Theoretical; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents
D004655:Emulsions; D005079:Excipients; D013501:Surface-Active Agents; D012710:Serum Albumin, Bovine; D005780:Gelatin; D017364:Collagenases; D005976:Glutaral