[Effect of nitric oxide on ATPase activity of smooth muscle actomyosin].
The effects of nitric oxide donor sodium nitroprusside (SNP) on ATPase activities of smooth muscle actomyosin and myosin were investigated. The effect of SNP on actomyosin ATPase activity was biphasic: the low concentration of this reagent increased the actomyosin ATPase activity while the high concentration exerted opposite effect. These effects were similar to those induced by the specific thiol-alkylating agent N-ethylmaleimide. These data demonstrate that nitric oxide exert the direct effect on smooth muscle contractile proteins. Such effect may be involved in physiological action of NO on smooth muscle.
Andrukhov
O Ia
OIa
Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv.
Danylova
V M
VM
Babiĭchuk
V S
VS
Sahach
V F
VF
D000205:Actomyosin / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D009130:Muscle, Smooth / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009569:Nitric Oxide / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D013552:Swine
D009599:Nitroprusside; D009569:Nitric Oxide; D000205:Actomyosin; D000251:Adenosine Triphosphatases