title: Protective role of Bacopa monniera on morphine-induced brain mitochondrial enzyme activity in rats.
abstract: Alcoholic extract of Bacopa monniera was tested for its protective role on morphine-induced brain mitochondrial enzyme status in rats. The level of the brain mitochondrial enzymes was significantly lower in the morphine-treated group when compared with control animals. These enzymes were maintained at normal level when Bacopa extract was administered orally at a dose of 40 mg/kg, 2 h before the administration of morphine.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, 600 025, Chennai, India.
authors.forename: T
authors.initials: T
authors.lastname: Sumathy
authors.forename: S
authors.initials: S
authors.lastname: Govindasamy
authors.forename: K
authors.initials: K
authors.lastname: Balakrishna
authors.forename: G
authors.initials: G
authors.lastname: Veluchamy
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D004347:Drug Interactions; D007194:India; D008297:Male; D008515:Medicine, Ayurvedic; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D009020:Morphine / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D009020:Morphine