Metastatic pulmonary adenocarcinoma in a llama (Lama glama).
An adult female llama with a comminuted fracture of the left femoral head was necropsied. A firm multinodular mass infiltrated skeletal muscle adjacent to the fracture. Multiple, firm, white nodules were in the pulmonary parenchyma and pleura. A single nodule was in the liver. Microscopically, transition from nonneoplastic bronchiolar epithelium to neoplastic epithelium that formed acinar structures was evident at bronchioloalveolar junctions. A diagnosis of pulmonary adenocarcinoma was made. Similar neoplastic tissue was in the liver and in the perifemoral mass. Immunohistochemically, neoplastic cells were positive for pan-cytokeratin, cytokeratin 7, and cytokeratin 5/6 antibodies and negative for vimentin and cytokeratins 8/18 and 20.
Ramos-Vara
José A
JA
Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia 65205, USA.
Miller
Margaret A
MA
D000230:Adenocarcinoma / Q000556:secondary / Q000662:veterinary*; D000818:Animals; D002161:Camelids, New World; D005260:Female; D005264:Femoral Fractures / Q000662:veterinary; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary / Q000662:veterinary*; D008175:Lung Neoplasms / Q000473:pathology / Q000662:veterinary*; D019042:Muscle Neoplasms / Q000556:secondary / Q000662:veterinary*