title: Modulation of natural killer cell activity affected by electroacupuncture through lateral hypothalamic area in rats.
abstract: Electroacupuncture (EA) has been reported to modulate natural killer cell (NK cell) activities. Also it is well known that hypothalamus directly mediates the effects of EA on analgesia. Especially lateral hypothalamic area (LHA) is related to splenic NK cell activities. In order to investigate the relationship between hypothalamus and effects of EA on NK cell activity, lesions have been made bilaterally at LHA of Spraque-Dawley rats. Subsequently, NK cell cytotoxities of normal and lesioned rats were measured with (51)Cr release immunoassay after EA stimulation for 2 and 14 days. NK cell activity of EA group was significantly higher than sham group. In addition, lesions abolished effects of EA on NK cell activity. These results strongly suggest that LHA is closely related to increase of NK cell activity induced by EA.
authors.affiliation: Department of East-West Medicine, Graduate School, Kyung Hee University, Seoul, South Korea.
authors.forename: G S
authors.initials: GS
authors.lastname: Choi
authors.forename: S D
authors.initials: SD
authors.lastname: Oha
authors.forename: J B
authors.initials: JB
authors.lastname: Han
authors.forename: H S
authors.initials: HS
authors.lastname: Bae
authors.forename: Y W
authors.initials: YW
authors.lastname: Cho
authors.forename: Y S
authors.initials: YS
authors.lastname: Yun
authors.forename: W K
authors.initials: WK
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Ahn
authors.forename: B I
authors.initials: BI
authors.lastname: Min
mesh_terms: D000818:Animals; D002860:Chromium Radioisotopes; D015671:Electroacupuncture; D007026:Hypothalamic Area, Lateral / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D002860:Chromium Radioisotopes