title: [A method for estimating penetrance of pathogenic mutations in a mitochondrial genome].
abstract: Variation in the manifestation age is typical of many mitochondrial diseases. The estimation of penetrance of pathogenic mutations causing such diseases is usually conducted on samples of individuals whose age exceeds the maximum age of the disease manifestation. In the case of rare diseases, samples of sufficient size sometimes cannot be formed. In this study, we propose a method for estimating penetrance involving individuals of any age. The efficiency of the method is demonstrated using Leber hereditary optic neuropathy as an example. It is shown that the method provides an unbiased estimate of penetrance and considerably reduces the error of this estimate in comparison with a sample including individuals whose age exceeds the maximum age of disease manifestation.
authors.affiliation: Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kirichenko
authors.forename: S I
authors.initials: SI
authors.lastname: Zhadanov
authors.forename: T I
authors.initials: TI
authors.lastname: Aksenovich
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D004272:DNA, Mitochondrial; D020022:Genetic Predisposition to Disease; D006801:Humans; D028361:Mitochondrial Diseases / Q000235:genetics*; D008957:Models, Genetic; D009154:Mutation; D029242:Optic Atrophy, Hereditary, Leber / Q000453:epidemiology / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial