In vitro and in vivo effects of [Ni(M5FTSC)2Cl2] complex in cancer: preliminary tests.
The human colon adenocarcinoma-derived cell line CaCo-2 male Swiss mice and male Sprague-Dawley rats were used as model systems to study the effects of nickel (II), 5-methyl-2-furaldehyde thiosemicarbazone ligand and their complex. The stimulation effect of the complex was obtained with low concentrations from 3.7 x 10(-7) to 3.7 x 10(-6) M, while inhibiting effects occurred from 3.7 x 10(-5) to 3.7 x 10(-4) M. This study showed that Ni (II) is toxic for cultured cells. Our data suggest that the comple; according to the toxicity assays in mice and carcinogenesis assays in rats, could be used as an antimitotic agent.
Jouad
El Mostapha
el M
Laboratoire de chimie de coordination, Faculte de Pharmacie, Angers, France.
Thanh
Xuan Do
XD
Bouet
Gilles
G
Bonneau
Stephanie
S
Khan
Mustayeen A
MA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D018938:Caco-2 Cells / Q000187:drug effects; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D008770:Methylnitrosourea; D051379:Mice; D009532:Nickel / Q000494:pharmacology* / Q000633:toxicity; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013882:Thiosemicarbazones / Q000494:pharmacology* / Q000633:toxicity
D000970:Antineoplastic Agents; D002273:Carcinogens; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C465020:dichloro(5-methyl-2-furaldehyde thiosemicarbazone)nickel(II); D008770:Methylnitrosourea; D009532:Nickel