Reduced production of interferon-gamma but not interleukin-10 in bipolar mania and subsequent remission.
BACKGROUND
Activation of inflammatory response system (IRS) is suggested by increased levels of plasma soluble interleukin-2 receptor (sIL-2R) in patients with bipolar mania. The reasons for changes in stimulated interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) production in bipolar mania along with subsequent remission remain unclear.


METHODS
We measured phytohemagglutinin (PHA)-stimulated IFN-gamma and IL-10 production in 20 physically healthy inpatients aged between 18 and 45 years with bipolar mania (DSM-IV) using Young Mania Rating Scale (YMRS) scores > or = 26 and in subsequent remission (YMRS < or = 12), as well as in 15 age- and sex-matched healthy normal controls.


RESULTS
The mean values of IFN-gamma production in patients in acute mania and in subsequent remission were significantly lower than those of healthy controls (P=0.0004, P=0.0005, respectively). There was no significant difference in IL-10 production between bipolar patients in acute mania as well as in subsequent remission and healthy controls. In acute mania, the mean values of IFN-gamma and IL-10 production in medicated patients (n = 13) did not differ from those of drug-free patients (n = 7). Other clinical variables had no effect on IFN-gamma and IL-10 production.


CONCLUSIONS
The uncontrolled medication, small sample size of the bipolar individuals, and some immune re-measurements prior to full remission periods, limit generalization from the data in this study.


CONCLUSIONS
Reduced production of IFN-gamma without alternation of IL-10 in bipolar mania and subsequent remission suggest that the immune modulation may vary in patients with different major psychiatric disorders.
Su
Kuan-Pin
KP
Department of Psychiatry, School of Medicine, Taipei Medical University Hospital, Taipei Medical University Wang Fang Hospital, Taipei, Taiwan [corrected].
Leu
Sy-Jye C
SJ
Yang
Yi-Yuan
YY
Shen
Winston W
WW
Chou
Yech-Mei
YM
Tsai
Shang-Ying M
SY
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000276:immunology* / Q000523:psychology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D012720:Severity of Illness Index
D016753:Interleukin-10; D007371:Interferon-gamma