title: Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using pi-allyltricarbonyliron lactone complexes.
abstract: The synthesis of taurospongin A has been achieved using, as a key step, a pi-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hollowood
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yamanoi
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis*; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D004952:Esters / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D058085:Iron Compounds; D007783:Lactones; D009682:Magnetic Resonance Spectroscopy; D019384:Nucleic Acid Synthesis Inhibitors; D011161:Porifera / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D004791:Enzyme Inhibitors; D004952:Esters; D007202:Indicators and Reagents; D058085:Iron Compounds; D007783:Lactones; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; C464964:taurospongin A