[Metabolic characteristics of immunocompetent cells in children with relapsing herpes].
Healthy children aged 1-6 years and patients of the same age with recurrent herpesvirus infection (RHVI) during remission were examined. The levels of NAD(P)-dependent dehydrogenases of blood lymphocytes were measured. Lymphocyte metabolism in the patients was characterized by activation of the key reaction of the pentose phosphate cycle, increased level of the mitochondrial compartment oxidoreductases, increased substrate flow through glucose-3-phosphate dehydrogenase, and inhibition of NADH-dependent dehydrogenase reactions of the cytoplasmatic compartment. A relationship between intracellular metabolism and incidence of RHVI relapses was detected. The metabolic status of blood lymphocytes did not normalize during RHVI remissions.
Kurtasova
L M
LM
Savchenko
A A
AA
Ruzaeva
L A
LA
Shmidt
A R
AR
D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D006561:Herpes Simplex / Q000201:enzymology / Q000276:immunology*; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology; D009252:NADPH Dehydrogenase / Q000097:blood*; D011379:Prognosis; D012008:Recurrence
D015415:Biomarkers; D009252:NADPH Dehydrogenase