Presence of integron-associated resistance in the community is widespread and contributes to multidrug resistance in the hospital.
Integrons are strongly associated with the multidrug resistance seen in gram-negative bacilli in the hospital environment. No data, however, are available on their prevalence in the community. This study is the first to show that integrons are widespread in Enterobacteriaceae in the community and that integron-associated resistance genes in the community constitute a substantial reservoir for multidrug resistance in the hospital.
Leverstein-Van Hall
M A
MA
Eijkman-Winkler Institute for Microbiology, Infectious Diseases & Inflammation, University Medical Center, Utrecht, The Netherlands. M.LeversteinvHall@lab.azu.nl
Paauw
A
A
Box
A T A
AT
Blok
H E M
HE
Verhoef
J
J
Fluit
A C
AC
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission*; D006761:Hospitals; D006801:Humans; D019426:Integrases / Q000235:genetics*; D015995:Prevalence
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D019426:Integrases