Mutagenic effects of carbosulfan, a carbamate pesticide.
The genotoxic effects of carbosulfan were evaluated using chromosome aberration (CA), bone marrow micronucleus (MN) and sperm abnormality assays in mice. All the three acute doses (1.25, 2.5 and 5mg/kg) of carbosulfan induced significant dose-dependent increase in the frequency of CA (P<0.02), micronucleated polychromatic erythrocytes (PCEs) (P<0.05) and sperm head abnormalities (P<0.05) but did not affect the total sperm count. The highest acute dose of carbosulfan induced >7-fold increase in the frequency of CA, >3.5-fold increase in the frequency of micronucleated PCEs and >4.6-fold increase in the frequency of sperms with abnormal head morphology following intraperitoneal exposure as compared to the untreated controls. The present findings suggest that carbosulfan is a potent genotoxic agent and may be regarded as a potential germ cell mutagen also.
Giri
Sarbani
S
Genetic Toxicology Laboratory, Department of Life Science, Assam University, P.O. Box 11, Silchar 788 011, India. girisarbani@yahoo.com
Giri
Anirudha
A
Sharma
Gouri Dutt
GD
Prasad
Surya Bali
SB
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D002219:Carbamates / Q000633:toxicity*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D013076:Sperm Count; D013077:Sperm Head / Q000187:drug effects
D002219:Carbamates; D009153:Mutagens; D010575:Pesticides; C035038:carbosulfan