title: Metabolic characteristics of women who developed ovarian hyperstimulation syndrome.
abstract: BACKGROUND
  The aim of this study was to investigate whether a higher incidence of hyperinsulinism is found in women who have suffered from ovarian hyperstimulation syndrome (OHSS) as compared with other IVF patients. Additionally, we also assessed whether any abnormalities in the haemostatic system were more frequent in women with a past history of OHSS.
  
  
  METHODS
  A pilot study was carried out involving OHSS patients and matched IVF patients. Homeostasis model assessment (HOMA) of insulin sensitivity was calculated. The main outcome measures were: insulin sensitivity, coagulation anomalies, factor V Leiden mutations, methylene tetrahydrofolate reductase (MTHFR) polymorphism and prothrombin gene mutation, protein C and protein S deficiency.
  
  
  RESULTS
  No increased incidence in hyperinsulism nor in abnormalities of the haemostatic system were observed.
  
  
  CONCLUSIONS
  This pilot study does not provide evidence for an increased prevalence of hyperinsulinism among women who have developed OHSS in the past.
authors.affiliation: Departments of Obstetrics and Gynaecology, IVF and Haematology, St Pierre University Hospital, Free University of Brussels, Rue Haute, 322, 1000 Brussels, Belgium. annickdelvigne@swing.be
authors.forename: Annick
authors.initials: A
authors.lastname: Delvigne
authors.forename: Karol
authors.initials: K
authors.lastname: Kostyla
authors.forename: Anne
authors.initials: A
authors.lastname: De Leener
authors.forename: Bernard
authors.initials: B
authors.lastname: Lejeune
authors.forename: Brigitte
authors.initials: B
authors.lastname: Cantiniaux
authors.forename: Pierre
authors.initials: P
authors.lastname: Bergmann
authors.forename: Serge
authors.initials: S
authors.lastname: Rozenberg
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D012720:Severity of Illness Index; D013927:Thrombosis / Q000209:etiology / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)