[Oxygen dependent metabolism of neutrophils and monocytes in patients with unstable angina and its correction with preductal].
Oxygen-dependent metabolism of neutrophils and monocytes and antioxidant defense and heparin and trimetasidine effects on them were studied in 39 patients with unstable angina. All the patients showed a significant activation of neutrophils and monocytes by NBT-test, insignificant one by chemiluminescence in active serum superoxide dismutase and reduced total antioxidative serum potential. There was also a moderate rise in the level of CIC in enhanced HBT-test. Heparin in unstable angina pectoris produced stimulation of oxygen-dependent metabolism of neutrophils and monocytes, ischemic damage to the myocardium was not changed. This was observed after treatment with preductal indicating antioxidant properties of this drug.
Romanov
V A
VA
Kratnov
A E
AE
Romanova
N V
NV
Khrustalev
O A
OA
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D006493:Heparin; D013482:Superoxide Dismutase; D014292:Trimetazidine; D010100:Oxygen