[A case of pulmonary thromboembolism after interruption of treatment with unfractionated heparin].
Pulmonary embolism is a quite frequent event (incidence 1/10000/year), and blood stasis, endothelial lesions and coagulation disorders are predisposable factors. Elective treatment is heparin, but the use of this medication is associated with a possible ipercoagulative rebound effect. The case presented is a patient with unstable angina treated with heparin infusion, who developed pulmonary embolism after discontinuation of heparin treatment; the patient didn't present a genetic coagulopathy. Others risk factors have been analyzed and it was observed that discontinuation of heparin infusion could have a predominant role in the development of thrombosis. A MedLine research on the rebound effect of heparin and how to reduce it has been carried out.
Paglia
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Cardiologia Universitaria, Ospedale San Giovanni Battista di Torino, Università degli Studi di Torino, Turin, Italy.
Carrieri
L
L
Oliaro
E
E
Bergerone
S
S
Mangiardi
L
L
Trevi
G P
GP
D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000209:etiology* / Q000517:prevention & control
D000925:Anticoagulants; D006493:Heparin