Designer glucocorticoids.
Glucocorticoids are the most effective anti-inflammatory agents known. However, the use of these powerful molecules is plagued by a host of serious, sometimes life-threatening side-effects. The search for new compounds that maintain the efficacy of the steroids without some of the side-effects has entered a new phase. New approaches are leading to novel kinds of steroidal and non-steroidal compounds with unique profiles that may represent the next generation of safer glucocorticoids.
Miner
Jeffrey N
JN
Department of Molecular and Cellular Biology, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA. jminer@ligand.com
D002626:Chemistry, Pharmaceutical; D015198:Designer Drugs; D015195:Drug Design; D005938:Glucocorticoids / Q000009:adverse effects / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011987:Receptors, Steroid / Q000378:metabolism
D015198:Designer Drugs; D005938:Glucocorticoids; D011987:Receptors, Steroid