[Immunoprophylaxis of postoperative inflammatory complications in thoracic and abdominal wounds].
Immune system (IS) was studied in 228 wounded with penetrating knife and shotgun wounds of the thorax and abdomen complicated by hemorrhage more than 1000 ml. Six variants of IS reaction to trauma, hemorrhage, surgical stress and intensive therapy 1-2 days after surgery were registered. Comparative analysis of laboratory and clinical efficacy of prophylactic use of leukinferon in 99 patients (test group) was carried out. Control group consisted of 129 patients matched by gender, age, type of wound, hemorrhage volume and fluid therapy. High immunoprophylactic efficacy of leukinferon was demonstrated. Period of immunorehabilitation (normalization of leukogram, correction of immune imbalance) in patients of the test group was shortened twice. Purulent complications rate reduced from 24.9 to 1.0%, hospital stay--from 41.7 +/- 3.6 to 16.3 +/- 1.1 days.
Bulava
G V
GV
Abakumov
M M
MM
Danielian
Sh N
ShN
Nikulina
V P
VP
Khvatov
V B
VB
D000007:Abdominal Injuries; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000276:immunology*; D016207:Cytokines / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000276:immunology* / Q000517:prevention & control*; D013898:Thoracic Injuries; D014948:Wounds, Gunshot / Q000601:surgery*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; C062252:leukinferon