Fluconazole therapy for Candida albicans urinary tract infections in infants.
Candiduria is rare in newborns and infants, occurring most often in patients with risk factors. When associated with a candidal bezoar in the urinary tract, candiduria is usually treated by systemic amphotericin B and flucytosine plus local irrigation with amphotericin B. We describe the successful treatment of five newborns with a urinary tract infection, on major urological malformations, due to Candida albicans (including three with a candidal bezoar) by fluconazole alone. No adverse effects or recurrences were observed. Fluconazole therapy permits early discharge from the hospital and seems suitable for infants and newborns with a C. albicans urinary tract infection.
Triolo
Valérie
V
Département de Pédiatrie, Hôpital de l'Archet 2, 151 avenue de Saint Antoine de Ginestière, BP 3079, 06202 Nice Cedex, France.
Gari-Toussaint
Martine
M
Casagrande
Florence
F
Garraffo
Rodolphe
R
Dageville
Christian
C
Boutté
Patrick
P
Bérard
Etienne
E
D000935:Antifungal Agents / Q000097:blood / Q000627:therapeutic use*; D001630:Bezoars / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy*; D015725:Fluconazole / Q000097:blood / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000935:Antifungal Agents; D015725:Fluconazole