A method for off-line nasal nitric oxide measurement.
We conducted a study to test the accuracy of an immediate and delayed off-line technique for measuring nasal nitric oxide (NO) by comparing it with on-line measurements. With the assistance of one volunteer, we obtained these measurements during 30 sessions over a period of 2 months. Off-line measurements were made immediately following the acquisition of NO samples and 1, 2, and 4 hours later. NO samples were obtained from nasal air collected in syringes. We found that the correlation between on-line measurements and the immediate and delayed off-line measurements ranged from 95 to 98%, according to a Bland-Altman analysis. We conclude that off-line nasal NO measurements can be reliably used in clinical practice and research projects, thus obviating the need for patients/subjects to be in close proximity to the analyzer. Off-line nasal NO measurements can effectively substitute for on-line measurements when the latter technique is not practical.
Gungor
Anil
A
Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213-2583, USA. anil.gungor@chp.edu
Vural
Cetin
C
D000328:Adult; D001944:Breath Tests / Q000379:methods; D016001:Confidence Intervals; D006801:Humans; D016014:Linear Models; D008297:Male; D009296:Nasal Cavity / Q000737:chemistry*; D009569:Nitric Oxide / Q000032:analysis*; D015203:Reproducibility of Results
D009569:Nitric Oxide