Cell polarity: posterior Par-1 prevents proteolysis.
The Par-1 kinase is required for anterior-posterior axis formation in Drosophila. New work has identified the posterior determinant, Oskar, as a Par-1 substrate. Phosphorylation stabilises Oskar, revealing a novel mechanism controlling its asymmetric distribution.
Benton
Richard
R
Wellcome Trust/Cancer Research UK Institute, Department of Genetics, University of Cambridge, Tennis Court Road, UK. rrb20@cam.ac.uk
St Johnston
Daniel
D
D000818:Animals; D029742:Caenorhabditis elegans Proteins; D016764:Cell Polarity; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D006868:Hydrolysis; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics
D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D012333:RNA, Messenger; C091675:osk protein, Drosophila; D017346:Protein Serine-Threonine Kinases