title: Diastereomer method for determining ee by (1)H NMR and/or MS spectrometry with complete removal of the kinetic resolution effect.
abstract: [structure: see text] Using chiral auxiliaries, 2-methoxy-2-(1-naphthyl)propionic acid (MalphaNP acid) (S)-(+)-1 and its deuterium-labeled enantiomer (R)-(-)-1-d(n)() (n = 3 or 6), we have developed a new diastereomer method for determining enantiomeric excess (% ee) of chiral alcohols by (1)H NMR and/or MS spectrometry, where the kinetic resolution effect is completely excluded. The data of % ee determined by this method agree well with those calculated by weight, the average error being ca. +/-1.08% ee.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba, Sendai 980-8577, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Taji
authors.forename: Masataka
authors.initials: M
authors.lastname: Watanabe
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Harada
authors.forename: Hideo
authors.initials: H
authors.lastname: Naoki
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Ueda