title: The development of an improved carrier system for sunscreen formulations based on crystalline lipid nanoparticles.
abstract: The aim of this study was the in vitro evaluation of the efficacy of two different carrier systems for the molecular sunscreen benzophenone-3. One carrier system was a conventional o/w emulsion, the other consisted of highly crystalline lipid nanoparticles (CLN). It was observed that CLN act as physical sunscreens themselves and show improved photoprotection compared with a placebo emulsion with the same lipid content. Incorporation of a molecular sunscreen further improves the protection level in a synergistic way. This in vitro study based on the Transpore test by Diffey showed that the amount of molecular sunscreen can be decreased by up to 50% while maintaining the UV protection efficacy. Therefore, the use of CLN as an active carrier for sunscreens is a promising innovation.
authors.affiliation: Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Kelchstr. 31, 12169, Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Wissing
authors.forename: R
authors.initials: R
authors.lastname: Müller
mesh_terms: D001577:Benzophenones / Q000008:administration & dosage* / Q000737:chemistry; D003460:Crystallization; D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D001577:Benzophenones; D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D013473:Sunscreening Agents; C047723:benzophenone