Efficiency and structure-activity relationship of the antioxidant action of resveratrol and its analogs.
Resveratrol and its analogs, six other polyhydroxystilbenes, were synthesized and their antioxidative activities were evaluated in vitro by determination of the levels of malondialdehyde and hydrogen peroxide. Results clearly exhibited that resveratrol and its analogs had various potencies in inhibiting lipid peroxidation in rat brain, kidney, and liver homogenates and rat erythrocyte hemolysis. Several polyhydroxystilbenes were found to be more active than resveratrol in these models, and structure-activity relationship studies on polyhydroxystilbenes are described in this paper.
Lu
M
M
National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, GanSu, P.R. China.
Cai
Y J
YJ
Fang
J G
JG
Zhou
Y L
YL
Liu
Z L
ZL
Wu
L M
LM
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006461:Hemolysis; D006861:Hydrogen Peroxide / Q000378:metabolism; D007202:Indicators and Reagents; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000975:Antioxidants; D007202:Indicators and Reagents; D013267:Stilbenes; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid; D000077185:Resveratrol