title: Sirolimus lowers myeloperoxidase and p-ANCA titers in a pediatric patient before kidney transplantation.
abstract: We report the case of a child with microscopic polyangiitis (myeloperoxidase-antineutrophil cytoplasmic antibody [p-ANCA]-positive vasculitis) whose disease progressed to end-stage renal failure, in whom sirolimus contributed to normalization of myeloperoxidase and ANCA titers. The disease course, various therapies, and outcome are discussed, as is the rationale for using sirolimus.
authors.affiliation: Department of Pediatric Nephrology and Transplant Surgery, University of Medicine and Dentistry of New Jersey-Robert Wood Jonson Medical School, New Brunswick, NJ 08903, USA. constaar@umdnj.edu
authors.forename: Alex R
authors.initials: AR
authors.lastname: Constantinescu
authors.forename: Michael
authors.initials: M
authors.lastname: Liang
authors.forename: David A
authors.initials: DA
authors.lastname: Laskow
mesh_terms: D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000097:blood / Q000276:immunology*; D020123:Sirolimus / Q000494:pharmacology / Q000627:therapeutic use*; D019172:Transplantation Conditioning / Q000379:methods*; D014657:Vasculitis / Q000150:complications
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D009195:Peroxidase; D020123:Sirolimus