title: [Effect of chronic stress during prepubertal period of life on development of inherited arterial hypertension].
abstract: The immediate and long-lasting effects of environmental stress during prepubertal life on arterial blood pressure (AP) were studied in rats with inherited stress-induced arterial hypertension (ISIAH) and normotensive Wistar rats. Two models of chronic stress (the 21st-32nd postnatal days) were used: repeated handling and unpredictable stress of daily exposures to a variety of mild physical or psychoemotional stressors. Chronic prepubertal stress did not affect the basal or stress-induced AP levels in young or adult Wistar rats. In ISIAH rats, chronic stress during the early phase of hypertension development did not accelerate its formation and did not augment its manifestation in adults. Moreover, the basal AP was decreased in young and adult ISIAH rats exposed to prepubertal stress as compared to the age-matched controls. AP elevation under acute stress conditions was lower in young ISIAH rats exposed to unpredictable stress. No long-lasting effect of prepubertal stress on acute stress-induced AP elevation in adults was found. The conclusion was drawn that moderate physical and psychoemotional training at prehypertensive stage can positively affect the development of inherited arterial hypertension.
authors.affiliation: Institute of Cytology and Genetics of the Russian Acad. Sci., Siberian Branch, 10 Pr. Lavrentyeva, Novosibirsk 630090, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslova
authors.forename: V V
authors.initials: VV
authors.lastname: Bulygina
authors.forename: A L
authors.initials: AL
authors.lastname: Markel'
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002908:Chronic Disease; D005260:Female; D006234:Handling, Psychological; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012054:Reinforcement, Psychology; D013045:Species Specificity; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*