title: Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia.
abstract: Several studies, including one from Japan, have observed an increase of Human Leukocyte Antigen (HLA)-A24 and A26 in schizophrenia, although others failed to observe the increase. No use of systematic diagnostic criteria and a not-adequately reliable typing technique might have affected the results in the previous studies. We investigated HLA-A specificities in Japanese patients with schizophrenia (DSM-IV), recruited from the same area as in the early Japanese study. A DNA-based technique (polymerase chain reaction-microtiter plate hybridization) was employed. No significant difference was observed in frequencies of any HLA-A specificities between patients and controls, including A24 and A26. No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.
authors.affiliation: Department of Psychiatry, Haryugaoka Hospital, 11 Tensyodan, Otsuki-machi, Koriyama City, Fukushima 963-0201, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Kohda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hibino
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Marui
authors.forename: Kanji
authors.initials: K
authors.lastname: Masui
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Sugahara
authors.forename: Ryo
authors.initials: R
authors.lastname: Kanamori
authors.forename: Takeo
authors.initials: T
authors.lastname: Juji
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D000939:Epitopes / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics*; D059871:HLA-A24 Antigen; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D012621:Seasons
chemical_list: D000939:Epitopes; D015234:HLA-A Antigens; C039683:HLA-A*26 antigen; D059871:HLA-A24 Antigen