title: Wnt signaling involvement in beta-amyloid-dependent neurodegeneration.
abstract: Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-beta peptide (Abeta). We have observed that Abeta-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients.
authors.affiliation: Center for Cell Regulation and Pathology, P. Catholic University of Chile, P.O. Box 114-D, Alameda 340, Santiago, Chile. ninestr@genes.bio.puc.cl
authors.forename: Nibaldo
authors.initials: N
authors.lastname: Inestrosa
authors.forename: Giancarlo V
authors.initials: GV
authors.lastname: De Ferrari
authors.forename: José L
authors.initials: JL
authors.lastname: Garrido
authors.forename: Alejandra
authors.initials: A
authors.lastname: Alvarez
authors.forename: Gonzalo H
authors.initials: GH
authors.lastname: Olivares
authors.forename: María I
authors.initials: MI
authors.lastname: Barría
authors.forename: Miguel
authors.initials: M
authors.lastname: Bronfman
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Chacón
mesh_terms: D016229:Amyloid beta-Peptides / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D006801:Humans; D009410:Nerve Degeneration / Q000503:physiopathology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D016229:Amyloid beta-Peptides; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins