title: Partial laryngectomy to treat early glottic cancer after failure of radiation therapy.
abstract: OBJECTIVE
  To evaluate the role of partial laryngectomy to treat glottic cancer after failure of radiation therapy.
  
  
  METHODS
  A 12-year retrospective outcome analysis.
  
  
  METHODS
  University referral center.
  
  
  METHODS
  A total of 19 patients who underwent partial laryngectomy to treat glottic cancer after failure of radiation therapy.
  
  
  RESULTS
  The follow-up period in this group ranged from 31 to 144 months. After surgery, a laryngocutaneous fistula was observed in 4 cases, and flap necrosis occurred in 2, but these complications were successfully managed. Maximum phonation time after surgery ranged from 3 to 28 seconds (median phonation time, 10.2 seconds). Of these 19 patients, 3 developed local recurrence. These cases were successfully treated with total laryngectomy. A surgical margin of less than 1 mm was found to be a significant risk factor for local recurrence after partial laryngectomy.
  
  
  CONCLUSIONS
  These results indicate that partial laryngectomy is a useful option for the treatment of irradiation failure in the treatment of stage I and stage II vocal cord carcinomas. However, careful follow-up is mandatory for patients with a small surgical margin.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Japan. makiko@jd5.so-net.ne.jp
authors.forename: Makiko
authors.initials: M
authors.lastname: Toma
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Nibu
authors.forename: Kazunari
authors.initials: K
authors.lastname: Nakao
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: Masato
authors.initials: M
authors.lastname: Mochiki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yuge
authors.forename: Atsuro
authors.initials: A
authors.lastname: Terahara
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugasawa
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D005500:Follow-Up Studies; D005931:Glottis / Q000503:physiopathology / Q000528:radiation effects* / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D007825:Laryngectomy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D010043:Outcome and Process Assessment, Health Care; D011183:Postoperative Complications; D020127:Recovery of Function / Q000502:physiology; D012189:Retrospective Studies; D016879:Salvage Therapy; D015996:Survival Rate; D013997:Time Factors; D017211:Treatment Failure