title: Cyclosporine A protects against apoptosis in ischaemic/reperfused rat kidneys.
abstract: 1. Renal ischaemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allografts. Cyclosporine A (CsA) has been used as an immunosuppressive agent in organ transplantation. In the present study, the effect of CsA on ischaemia/reperfusion-induced apoptosis in the kidney was investigated. 2. Ischaemia/reperfusion injury caused widespread apoptosis primarily in the medulla of the kidney. At 1.5 mg/kg per day, CsA significantly reduced the number of apoptotic cells in rat kidney after ischaemia/reperfusion injury. 3. Low-dose CsA treatment did not affect the levels of creatinine in the serum of rats after ischaemia/reperfusion injury.
authors.affiliation: Department of Pharmacology and Institute of Cardiovascular Science and Medicine, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China.
authors.forename: Tongyu
authors.initials: T
authors.lastname: Zhu
authors.forename: Kathy K W
authors.initials: KK
authors.lastname: Au-Yeung
authors.forename: Yaw L
authors.initials: YL
authors.lastname: Siow
authors.forename: Guoping
authors.initials: G
authors.lastname: Wang
authors.forename: Karmin
authors.initials: K
authors.lastname: O
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology
chemical_list: D016572:Cyclosporine