title: Reproductive semi-cloning respecting biparental embryo origin: embryos from syngamy between a gamete and a haploidized somatic cell.
abstract: Embryos formed by somatic cell nuclear transfer to enucleated oocytes (cloning) have given rise to viable offspring in several mammalian species. The possibility of future application of this technique to human assisted reproduction (reproductive cloning) has been widely debated. On this background there is current discussion of the potential for a cloning-derived technique, which aims at syngamy between a gamete nucleus from one parent and a somatic cell nucleus from the other. Critical analysis of the clinical indications, the current state of the art, biological concerns and ethical considerations relative to this technique, called here reproductive semi-cloning, are presented. Such a technique requires validation by further research before it can be considered as a treatment option. This debate explores issues raised by the technique.
authors.affiliation: Laboratoire d'Eylau, 55 rue Saint-Didier, 75116 Paris, France and Molecular Assisted Reproduction and Genetics, Gracia 36, 18002 Granada, Spain. rtesarik@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Tesarik
mesh_terms: D000818:Animals; D001675:Bioethics; D002467:Cell Nucleus; D002477:Cells; D020090:Chromosome Segregation; D019976:Cloning, Organism / Q000379:methods*; D018392:Genomic Imprinting; D005854:Germ Cells; D006238:Haploidy; D006801:Humans
keywords: Genetics and Reproduction