title: Acetaminophen (paracetamol)-induced anaphylactic shock.
abstract: Acetaminophen (paracetamol) is a widely prescribed analgesic-antipyretic drug. Adverse allergic reactions to this drug are rare. We report a case of anaphylactic shock due to acetaminophen. Results of skin prick tests and intradermal tests were negative. Oral rechallenge resulted in generalized urticaria associated with an increased plasma level of histamine. Acetaminophen should be added to the list of causes of anaphylaxis.
authors.affiliation: Département de Médecine Interne, Hôpital Laënnec, Creil, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Bachmeyer
authors.forename: Christophe
authors.initials: C
authors.lastname: Vermeulen
authors.forename: Redouane
authors.initials: R
authors.lastname: Habki
authors.forename: Frederic
authors.initials: F
authors.lastname: Blay
authors.forename: Francisque
authors.initials: F
authors.lastname: Leynadier
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D007279:Injections, Subcutaneous; D014581:Urticaria / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D006632:Histamine; D004837:Epinephrine