Enantioselective total synthesis of (+)-testudinariol a using a new nickel-catalyzed allenyl aldehyde cyclization.
An enantioselective total synthesis of (+)-testudinariol A was completed. A new nickel-catalyzed allenyl aldehyde cyclization was developed in the approach. In addition, an asymmetric anti aldol reaction and a two-directional oxocarbenium ion/vinyl silane condensation were employed as key steps.
Amarasinghe
Kande K D
KK
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Montgomery
John
J
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000138:chemical synthesis*
D000447:Aldehydes; D014315:Triterpenes; C465964:testudinariol A; D009532:Nickel