Mitomycin C as adjunct therapy in correcting punctal stenosis.
OBJECTIVE
To assess the efficacy of intraoperative mitomycin C in improving the success rate of the posterior punctectomy procedure.


METHODS
The charts of all patients who underwent posterior punctectomy between the years 1997 and 2000 were reviewed. The procedure was done without mitomycin C (n = 26 eyes, group A) until the end of 1998 and with mitomycin C (n = 25 eyes, group B) starting in 1999. The Kaplan-Meier curve was used for statistical evaluation.


RESULTS
In group A, 5 of 26 (19.2%) eyes had complete anatomic obstruction and scarring of their puncta after surgery, compared with 0 of 25 (0.0%) eyes in group B. The difference was statistically significant (P<0.02). No significant complications were observed.


CONCLUSIONS
Mitomycin C appears to be a safe and effective adjunct therapy in correcting punctal stenosis.
Ma'luf
Riad N
RN
Department of Ophthalmology, American University of Beirut-Medical Center, Beirut, Lebanon. RMALUF@cyberia.net.lb
Hamush
Nicolas G
NG
Awwad
Shady T
ST
Noureddin
Baha' N
BN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005141:Eyelid Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D014945:Wound Healing
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin