title: Relationships between seasonality and alcohol use: a genetic hypothesis.
abstract: Seasonal changes in mood and behavior (seasonality) are common throughout the population. Alcohol use and alcohol-related problems are also very common in society. Recent data suggest that seasonality is closely related to alcoholism. Some patients with alcoholism have a seasonal pattern to their alcohol abuse. Patients with alcoholism may be self-medicating an underlying seasonal affective disorder (SAD) with alcohol or manifesting a seasonal pattern to alcohol-induced depression. Family studies also suggest that there is a relationship between alcoholism and SAD. The author proposes that there is a genetic link between seasonality and alcoholism. This relationship is complex and involves various factors. It could be an inherited personality dimension, i.e., certain personality types may predispose to both seasonality and excessive alcohol consumption. SAD may be a subtype of mood disorder that is closely related to alcoholism. More studies are needed to better understand the mechanisms involved in the relationship between seasonality and alcohol use.
authors.forename: Leo
authors.initials: L
authors.lastname: Sher
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics; D000437:Alcoholism / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012307:Risk Factors; D016574:Seasonal Affective Disorder / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D012621:Seasons; D050486:Serotonin Plasma Membrane Transport Proteins; D019966:Substance-Related Disorders / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins