Structure and function of water channels.
All aquaporins are efficient water transporters, while sustaining strict selectivity, even against protons, thereby maintaining the proton gradient across the cell membrane. Recently solved structures of these membrane channels have helped us to understand this remarkable property.
Fujiyoshi
Yoshinori
Y
Department of Biophysics, Faculty of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo-ku, Japan. yoshi@em.biophys.kyoto-u.ac.jp
Mitsuoka
Kaoru
K
de Groot
Bert L
BL
Philippsen
Ansgar
A
Grubmüller
Helmut
H
Agre
Peter
P
Engel
Andreas
A
D020346:Aquaporins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure*; D018360:Crystallography, X-Ray; D008565:Membrane Proteins / Q000737:chemistry / Q000648:ultrastructure; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry* / Q000378:metabolism
D020346:Aquaporins; D008565:Membrane Proteins; D014867:Water