title: Effect of ligand structure on the zinc-catalyzed Henry reaction. Asymmetric syntheses of (-)-denopamine and (-)-arbutamine.
abstract: [reaction: see text] Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the beta-receptor agonists (-)-denopamine and (-)-arbutamine.
authors.affiliation: Department of Chemistry, Stanford University, California 94305-5080, USA. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Vince S C
authors.initials: VS
authors.lastname: Yeh
authors.forename: Hisanako
authors.initials: H
authors.lastname: Ito
authors.forename: Nadine
authors.initials: N
authors.lastname: Bremeyer
mesh_terms: D002395:Catecholamines / Q000138:chemical synthesis* / Q000378:metabolism; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000378:metabolism; D008024:Ligands; D015032:Zinc / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D004983:Ethanolamines; D008024:Ligands; C076559:arbutamine; D015032:Zinc; C037293:denopamine