title: [Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis].
abstract: OBJECTIVE
  To evaluate further the nature of HLA-DQB1 alleles association with dermatomyositis/polymyositis (DM/PM).
  
  
  METHODS
  HLA-DQB1 typing of 52 patients with DM/PM were investigated by polymerase chain reaction-sequence  specific primer method, and the frequencies of HLA-DQB1 alleles were compared.
  
  
  RESULTS
  It was found that the patients with DM/PM had significantly increased frequency of HLA-DQB1*0401(RR=3.56, P=1.79  10(-3), Pc<0.05).
  
  
  CONCLUSIONS
  The results suggest that HLA-DQB1*0401 gene contribute to genetic susceptibility to DM/PM.
authors.affiliation: Department of Dermatology, the First Hospital, China Medical University, Shenyang, Liaoning, 110001 P.R.China. nzhai@sina.com
authors.forename: Xiuping
authors.initials: X
authors.lastname: Han
authors.forename: Ning
authors.initials: N
authors.lastname: Zhai
authors.forename: Qingrui
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jiuhong
authors.initials: J
authors.lastname: Li
authors.forename: Jifeng
authors.initials: J
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Fangji
authors.initials: F
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D003882:Dermatomyositis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen