Contraction and relaxation indices in the study of neural inotropic and loositropic influences on the heart.
The possibility of using contraction and relaxation indices for evaluation of inotropic and loositropic influences on the heart was studied in experiments on cats. Increased pre- and afterload were used as the stimuli, which are simultaneously loading and reflexogenic. Under conditions of preserved innervation both stimuli elevated the indices selected according to the highest sensitivity/specificity ratio. Ganglionic blocker arfonad potentiated the effects of these stimuli. This attests to a considerable contribution of the myogenic component to the changes in the studied indices in response to increased pre- and afterload and to the existence of negative inotropic and loositropic influences on the heart under conditions of preserved innervation. These conclusions were supported when more specific indices were used: in most cases they decreased during load tests. Thus, when the contraction and relaxation indices are used for evaluation inotropic and loositropic influences on the heart, it seems reasonable either to compare heart responses under conditions of preserved or blocked innervation, or to apply more specific indices. Analysis of changes in most widely used indices (dP/dt)max and t showed that t reliably reflects neural loositropic influences, while the use of (dP/dt)max without proper control can be erroneous.
Alipov
N N
NN
Department of Normal Physiology, Russian State Medical University, Moscow. alipov@practica.ru
Sokolov
A V
AV
Trubetskaya
L V
LV
Kuznetsova
T E
TE
D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure; D002415:Cats; D006321:Heart / Q000502:physiology*; D009200:Myocardial Contraction; D014294:Trimethaphan / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D014294:Trimethaphan; C017774:trimethaphan camsylate