title: Possible synergy between recombinant factor VIIa and prothrombin complex concentrate in hemophilia therapy.
abstract: Recombinant factor VIIa (rFVIIa; Novoseven) is used for treatment of hemophilia patients with inhibitors. There are poorly defined differences in clinical responsiveness between individuals. Prior to licensure in the United States, rFVIIa was available through the compassionate use program, during which two patients described in this study demonstrated an excellent response. More recently, one of these individuals showed a sub-optimal response to rFVIIa. One possible explanation for different treatment outcomes was sequential therapy with prothrombin complex concentrates (PCC) followed by rFVIIa in the compassionate use program. In support of this, an in vitro test showed that this patient had an exceptionally strong response to rFVIIa when it was added to whole blood after the patient received PCC therapy. Results with other patients supported this hypothesis. With further evaluation, a therapeutic approach combining sequential PCC and rFVIIa may prove useful for treatment of bleeding refractory to either agent used alone.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis, USA. nelse002@tc.umn.edu
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Key
authors.forename: Beverly
authors.initials: B
authors.lastname: Christie
authors.forename: Nicole
authors.initials: N
authors.lastname: Henderson
authors.forename: Gary L
authors.initials: GL
authors.lastname: Nelsestuen
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000008:administration & dosage*; D001780:Blood Coagulation Tests; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005167:Factor VII / Q000008:administration & dosage*; D015942:Factor VIIa; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy*; D006470:Hemorrhage / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011516:Prothrombin / Q000008:administration & dosage; D011994:Recombinant Proteins / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D001779:Blood Coagulation Factors; D011994:Recombinant Proteins; C025667:prothrombin complex concentrates; D005167:Factor VII; D011516:Prothrombin; C103587:recombinant FVIIa; D015942:Factor VIIa