Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.
We studied here the long-term maintenance of distinct populations of T helper type 1 (T(H)1)-lineage cells in vivo and found that effector T(H)1 cells, defined by their secretion of interferon-gamma (IFN-gamma), are short-lived and do not efficiently develop into long-term memory T(H)1 cells. In contrast, a population of activated T(H)1-lineage cells that did not secrete IFN-gamma after primary antigenic stimulation persisted for several months in vivo and developed the capacity to secrete IFN-gamma upon subsequent stimulation. These data suggest that a linear differentiation pathway, as defined by the transition from IFN-gamma-producing to resting memory cells, is relatively limited in vivo and support a revised model for T(H)1 memory differentiation.
Wu
Chang-You
CY
Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3005, USA.
Kirman
Joanna R
JR
Rotte
Masashi J
MJ
Davey
Dylan F
DF
Perfetto
Steve P
SP
Rhee
Elizabeth G
EG
Freidag
Brenda L
BL
Hill
Brenna J
BJ
Douek
Daniel C
DC
Seder
Robert A
RA
D000818:Animals; D016923:Cell Death; D019070:Cell Lineage; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000502:physiology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D018417:Th1 Cells / Q000276:immunology* / Q000502:physiology
D007371:Interferon-gamma