Hepatobiliary excretion of dipyrrinone sulfonates in Mrp2-deficient (TR(-)) rats.
The biliary excretion of the sodium salts of 8-(2-ethanesulfonic acid)-3-ethyl-2,7,9-trimethyl-1,10-dihydro-11H-dipyrrin-1-one (xanthosulfonic acid) and a fluorescent analogue (8-desethyl-N,N'-carbonyl-kryptopyrromethenone-8-sulfonic acid) was compared in Mrp2-deficient (TR(-)) and normal rats. Both organic anions were excreted rapidly in bile in Mrp2-deficient rats, but the biliary excretion of the fluorescent sulfonate was impaired relative to normal controls. The rat clearly has efficient Mrp2-independent mechanisms for biliary efflux of these anions that are not used by bilirubin or its mono- and diglucuronides.
McDonagh
Antony F
AF
Division of Gastroenterology, S-357, Box 0538, University of California, San Francisco, CA 94143-0538, USA. tonymcd@itsa.ucsf.edu
Lightner
David A
DA
Boiadjiev
Stefan E
SE
Brower
Justin O
JO
Norona
Wilma S
WS
D000476:Alkanesulfonates / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D000818:Animals; D001647:Bile Acids and Salts; D001659:Biliary Tract / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005456:Fluorescent Dyes / Q000008:administration & dosage; D026901:Membrane Transport Proteins; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000502:physiology*; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley
D000476:Alkanesulfonates; D001647:Bile Acids and Salts; D005456:Fluorescent Dyes; D026901:Membrane Transport Proteins; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins