Thyrotoxicosis due to metastatic papillary thyroid cancer in a patient with Graves' disease.
Thyrotoxicosis resulting from functional thyroid cancer metastases is extremely rare, and is mostly caused by follicular cancer. The lesions causing thyrotoxicosis are usually bulky and extensive. We report here a patient with Graves' disease and concomitant papillary thyroid cancer who developed metastases causing symptomatic thyrotoxicosis. His serum titers of thyroid stimulating Ig (TSIs) were elevated. We believe that TSIs were responsible for thyrotoxicosis by stimulating hormonogenesis in the metastatic lesions.
Basaria
S
S
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Salvatori
R
R
D000368:Aged; D013956:Antithyroid Agents / Q000627:therapeutic use; D002291:Carcinoma, Papillary / Q000150:complications* / Q000556:secondary / Q000628:therapy; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D009362:Neoplasm Metastasis / Q000276:immunology; D011441:Propylthiouracil / Q000627:therapeutic use; D011859:Radiography; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000150:complications* / Q000628:therapy; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D013974:Thyroxine / Q000627:therapeutic use
D013956:Antithyroid Agents; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes; D011441:Propylthiouracil; D013974:Thyroxine