Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana.
Goodyerin is a flavonol glycoside isolated from the whole plants of Goodyera schlechtendaliana which has been used as a substitute for the crude drug, Anoectochilus formosanus. The pharmacological properties of goodyerin were assayed for effects on spontaneous locomotor activity, on pentobarbital-induced hypnosis, and on anticonvulsant activity against picrotoxin-induced seizures in rodents. Goodyerin exhibited a significant and dose-dependent sedative and anticonvulsant effect.
Du
Xiao-Ming
XM
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Sun
Ning-Yi
NY
Takizawa
Nanako
N
Guo
Yong-Tian
YT
Shoyama
Yukihiro
Y
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D003292:Convulsants / Q000494:pharmacology; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D044948:Flavonols; D006027:Glycosides / Q000494:pharmacology / Q000627:therapeutic use; D006993:Hypnotics and Sedatives / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D029595:Orchidaceae; D010424:Pentobarbital / Q000494:pharmacology; D008517:Phytotherapy; D010852:Picrotoxin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D012893:Sleep Wake Disorders / Q000139:chemically induced / Q000188:drug therapy
D000927:Anticonvulsants; D003292:Convulsants; D004187:Disaccharides; D005419:Flavonoids; D044948:Flavonols; D006027:Glycosides; D006993:Hypnotics and Sedatives; D010424:Pentobarbital; D010852:Picrotoxin; D010936:Plant Extracts; C470020:3-((6-O-(6-deoxymannopyranosyl)glucopyranosyl)oxy)-5,7-dihydroxy-8-((4-hydroxy-3,5-dimethoxyphenyl)methyl)-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one