title: The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis.
abstract: BACKGROUND
  The systemic anaphylaxis reaction comprises various symptoms, including hypotension, changes in respiration pattern, and hypothermia.
  
  
  OBJECTIVE
  To elucidate the role of histamine in each of these symptoms, we induced the passive systemic anaphylaxis reaction in histidine decarboxylase gene knockout (HDC [-/-]) mice, which lack histamine.
  
  
  METHODS
  HDC(-/-) mice were generated by knocking out the HDC gene, which codes for the unique histamine-synthesizing enzyme. Twenty-four hours after the injection of IgE, HDC(+/+) and HDC(-/-) mice were injected with allergen and body temperature, blood pressure, and respiratory function were monitored in each mouse.
  
  
  RESULTS
  Blood pressure dropped in both the HDC(-/-) mice and the HDC(+/+) mice. In contrast, respiratory frequency dropped and the expiratory respiration time was elongated only in the HDC(+/+) mice. Body temperature was decreased in the HDC(+/+) mice and was practically unchanged in the HDC(-/-) mice. Histamine receptor antagonists blocked the body temperature drop in the HDC(+/+) mice. Intravenous histamine induced similar patterns of body temperature decrease in the HDC(+/+) mice and the HDC(-/-) mice. Mast cell-deficient W/W (v) mice did not show the decrease in body temperature; this suggests that the histamine that contributed to the decrease in body temperature was derived from mast cells.
  
  
  CONCLUSIONS
  According to the results of this investigation, in the passive systemic anaphylaxis reaction, respiratory frequency, expiratory time, and body temperature are shown to be controlled by the activity of histamine, but its contribution to blood pressure is negligible.
authors.affiliation: Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine, Seiryo-cho 2-1, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Makabe-Kobayashi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hori
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Adachi
authors.forename: Satsuki
authors.initials: S
authors.lastname: Ishigaki-Suzuki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kagaya
authors.forename: Kunio
authors.initials: K
authors.lastname: Shirato
authors.forename: András
authors.initials: A
authors.lastname: Nagy
authors.forename: Azusa
authors.initials: A
authors.lastname: Ujike
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takai
authors.forename: Takehiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtsu
mesh_terms: D000485:Allergens / Q000276:immunology*; D000707:Anaphylaxis / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002927:Cimetidine / Q000494:pharmacology; D006632:Histamine / Q000097:blood / Q000276:immunology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000235:genetics / Q000502:physiology; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000008:administration & dosage / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D011738:Pyrilamine / Q000494:pharmacology; D012129:Respiratory Function Tests; D013990:Tidal Volume; D014301:Trinitrobenzenes / Q000276:immunology*
chemical_list: D000485:Allergens; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D014301:Trinitrobenzenes; D007073:Immunoglobulin E; D002927:Cimetidine; D006632:Histamine; D006640:Histidine Decarboxylase; D011738:Pyrilamine