[A study of the relationship between MICA gene and systemic lupus erythematosus].
OBJECTIVE
To investigate the relationship between major histocompatibility complex class I chain-related A(MICA) gene and systemic lupus erythematosus (SLE).


METHODS
The alleles and frequencies of exons 4 and 5 of MICA gene were determined in 70 cases of SLE and 152 controls of Yunnan Hans by STR genotyping, polymerase chain reaction, single strand conformation polymorphism and bidirection DNA sequencing.


RESULTS
Five alleles of exon 5 and 10 alleles of exon 4 were found in this study. The frequency of each allele was determined in patients and controls. There was no significant difference between the two groups in exons 4 and 5 of MICA gene.


CONCLUSIONS
Exons 4 and 5 of MICA were not related to SLE in Yunnan Hans.
Ban
Guihong
G
Department of Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan, 650118 P.R. China. chujy@public.km.yn.cn
Chu
Jiayou
J
Mao
Changzhi
C
Yang
Zhaoqing
Z
Xu
Shaobin
S
Chu
Zhengtao
Z
Huang
Xiaoqin
X
Zhang
Sizhong
S
D000483:Alleles; D002681:China; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D004247:DNA