title: Prestimulus effects on startle magnitude: sensory or motor?
abstract: Startle may be inhibited when the startling event is preceded by a stimulus; this is called prepulse inhibition (PPI) when the prestimulus is weak and nonstartling (s) and paired pulse inhibition when the prestimulus elicits startle (S1). The authors examined the relationship of these measures across species and tested whether paired pulse inhibition--like PPI--is independent of the startling effects of the prestimulus. PPI (s-S1 configuration) and paired pulse inhibition (S1-S2 configuration) were elicited in 1 test, using similar stimulus parameters in rats and humans. The amount of PPI and paired pulse inhibition was significantly correlated within subjects in both rats and humans. Paired pulse inhibition was not diminished when the startling effects of S1 were eliminated by a weak prepulse (s-S1-S2 configuration), nor was it enhanced when these prepulse effects were eliminated by the dopamine agonist apomorphine (in rats). Despite apparent differences in the inhibitory processes mediating PPI and paired pulse inhibition, both are independent of the motoric response to the prestimulus.
authors.affiliation: Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla 92093-0804, USA. nswerdlow@ucsd.edu
authors.forename: Neal R
authors.initials: NR
authors.lastname: Swerdlow
authors.forename: Jody M
authors.initials: JM
authors.lastname: Shoemaker
authors.forename: Nora
authors.initials: N
authors.lastname: Stephany
authors.forename: Lindsay
authors.initials: L
authors.lastname: Wasserman
authors.forename: Hyun J
authors.initials: HJ
authors.lastname: Ro
authors.forename: Mark A
authors.initials: MA
authors.lastname: Geyer
mesh_terms: D000328:Adult; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003214:Conditioning, Classical; D018491:Dopamine Agonists / Q000494:pharmacology; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011931:Reactive Inhibition; D013216:Reflex, Startle / Q000502:physiology*
chemical_list: D018491:Dopamine Agonists; D001058:Apomorphine