title: D-dimer and platelet aggregability are related to thrombotic events in patients with peripheral arterial occlusive disease.
abstract: OBJECTIVE
  To evaluate the frequency of arterial thrombotic events in patients with peripheral arterial occlusive disease during 3-5 years of follow-up and to determine whether baseline levels of haemostatic factors were related to the risk of future thrombotic events.
  
  
  RESULTS
  One hundred and twenty-three patients, mean age 56 years, with peripheral arterial occlusive disease and intermittent claudication were followed prospectively for an average of 4.2 years. Fibrinogen, prothrombin fragment 1+2, D-dimer, tissue plasminogen activator, plasminogen activator inhibitor type I antigen and activity, plasmin-alpha(2)-antiplasmin complex, beta thromboglobulin and ADP-induced platelet aggregation were measured at the recruitment. Thirty-eight new vascular events (15 fatal) were identified. Age- (and other clinical and laboratory variables) -adjusted relative risks (RR) of thrombotic events were significantly elevated (P<0.05) per higher value of D-dimer (RR: 14.1, 95% CI 1.7;115.8) and platelet aggregation was low (RR: 4.6, 95% CI 1.3;16.3). Diabetes mellitus, cerebrovascular disease, and continuing deterioration of intermittent claudication at the recruitment were also independently associated with risk of thrombotic events in the multiple regression model (RR: 5.2, 95% CI 1.5;17.5; RR: 8.6, 95% CI 2.7;27.4; RR: 2.6, 95% CI 1.2;5.7 respectively).
  
  
  CONCLUSIONS
  Elevated level of D-dimer and low platelet aggregation are independent haemostatic predictors of thrombotic events in patients with peripheral arterial occlusive disease.
authors.affiliation: Department of Atherothrombosis, Cardiology Research Center, Moscow, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Komarov
authors.forename: E
authors.initials: E
authors.lastname: Panchenko
authors.forename: A
authors.initials: A
authors.lastname: Dobrovolsky
authors.forename: Yu
authors.initials: Y
authors.lastname: Karpov
authors.forename: A
authors.initials: A
authors.lastname: Deev
authors.forename: E
authors.initials: E
authors.lastname: Titaeva
authors.forename: K
authors.initials: K
authors.lastname: Davletov
authors.forename: A
authors.initials: A
authors.lastname: Eshkeeva
authors.forename: L
authors.initials: L
authors.lastname: Markova
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000150:complications; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000150:complications; D010974:Platelet Aggregation; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D