Syntheses of Metal Phthalocyanines and Their Photoinactivations on Cancer Cells.
This paper reported the syntheses of amphiphilic substituted metal phthalocyanines containig sulfonic acid groups and phthalimidomethyl groups (MPcSP, M=Zn or Al(OH), S=-SO(3)(-), P=phthalimidomethyl). We have selected zinc phthalocyanine (Zn-D) as the one with better cell killing potential by an in vitro cell survival assay. Over 90 % tumor cells were killed with 10 mg/L Zn-D, after they were exposed to 12 J/cm(2) red light.
Liu
Er-Sheng
ES
Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China.
Dai
Zhi-Fei
ZF
Huang
Jian-Dong
JD
Chen
Nai-Sheng
NS
Huang
Jin-Ling
JL
Huang
Zi-Qiang
ZQ
Sun
Jian-Cheng
JC