Adapting arrays and lab-on-a-chip technology for proteomics.
The impact of proteomics as a discovery engine in life science and in drug discovery has increased tremendously over the last seven years. At the same time, proteomics has expanded from the initial trust as a two-dimensional gel based approach to cover more functional and structural properties of proteins. The development of lab-on-a-chip and protein arrays for proteomics will have to evolve with the changes in proteomics to stay relevant. Here, we review the changes in the field of proteomics and their impact on the development in protein arrays and lab-on-a-chip.
Figeys
Daniel
D
MDS-Proteomics, Toronto, Ontario, Canada. d.figeys@mdsp.com
D000906:Antibodies; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D040081:Protein Array Analysis; D011506:Proteins / Q000032:analysis* / Q000737:chemistry; D040901:Proteomics / Q000295:instrumentation / Q000379:methods; D020539:Sequence Analysis, Protein
D000906:Antibodies; D011506:Proteins