Autoantibody in a patient with chronic hepatitis C virus infection showing complete remission after interferon therapy.
A 42-year-old woman was admitted to Kinashi Ohbayashi Hospital for liver dysfunction. She presented with hepatitis C viral infection accompanied by autoimmune hepatitis-like serological manifestations, such as antinuclear antibody (ANA), antismooth muscle cell antibody and especially anti-ribonucleoprotein (RNP) antibody and anti-SSB antibody. After interferon therapy, hepatitis C virus was not detected and ANA, anti-RNP antibody and anti-SSB antibody disappeared. To our knowledge, this is the first reported hepatitis C patient showing anti-RNP antibody and anti-SSB antibody, having complete remission after interferon therapy.
Akashi
Yoshihiro
Y
Department of Internal Medicine, Kinashi Ohbayashi Hospital, Kagawa, Japan. akashi@niji.or.jp
Inoh
Masayuki
M
Seto
Kunio
K
Gamo
Naoyuki
N
Kuboki
Makoto
M
Kurata
Noriyuki
N
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D012074:Remission Induction
D000998:Antiviral Agents; D001323:Autoantibodies; D016898:Interferon-alpha