title: The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum.
abstract: We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this gene is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit.
authors.affiliation: MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
authors.forename: Robindra N
authors.initials: RN
authors.lastname: Gogoi
authors.forename: Frank R
authors.initials: FR
authors.lastname: Schubert
authors.forename: Juan-Pedro
authors.initials: JP
authors.lastname: Martinez-Barbera
authors.forename: Dario
authors.initials: D
authors.lastname: Acampora
authors.forename: Antonio
authors.initials: A
authors.lastname: Simeone
authors.forename: Andrew
authors.initials: A
authors.lastname: Lumsden
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology*; D002645:Chickens; D003001:Cloning, Molecular; D004475:Ectoderm / Q000378:metabolism; D004707:Endoderm / Q000378:metabolism; D018398:Homeodomain Proteins / Q000096:biosynthesis* / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D008636:Mesencephalon / Q000196:embryology*; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D051857:Otx Transcription Factors; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017434:Protein Structure, Tertiary; D014018:Tissue Distribution; D015534:Trans-Activators / Q000096:biosynthesis
chemical_list: D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051857:Otx Transcription Factors; C497660:Otx2 protein, mouse; D015534:Trans-Activators