title: Structure and function of water channels.
abstract: All aquaporins are efficient water transporters, while sustaining strict selectivity, even against protons, thereby maintaining the proton gradient across the cell membrane. Recently solved structures of these membrane channels have helped us to understand this remarkable property.
authors.affiliation: Department of Biophysics, Faculty of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo-ku, Japan. yoshi@em.biophys.kyoto-u.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiyoshi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Mitsuoka
authors.forename: Bert L
authors.initials: BL
authors.lastname: de Groot
authors.forename: Ansgar
authors.initials: A
authors.lastname: Philippsen
authors.forename: Helmut
authors.initials: H
authors.lastname: Grubmüller
authors.forename: Peter
authors.initials: P
authors.lastname: Agre
authors.forename: Andreas
authors.initials: A
authors.lastname: Engel
mesh_terms: D020346:Aquaporins / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure*; D018360:Crystallography, X-Ray; D008565:Membrane Proteins / Q000737:chemistry / Q000648:ultrastructure; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D020346:Aquaporins; D008565:Membrane Proteins; D014867:Water