title: In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.
abstract: Some quassinoids (1-6) isolated previously as plant growth inhibitors from the leaves of Eurycoma longifolia Jack. (Simaroubaceae) were subjected to in vitro tests on anti-tumor promoting, antischistosomal and plasmodicidal activities. The most active compound for inhibition of tumor promoter-induced Epstein-Barr virus activation (anti-tumor promotion) was 14,15beta-dihydroxyklaineanone (5, IC(50) = 5 microM). Longilactone (1) gave significant antischistosomal effect at a concentration of 200 microg/ml. 11-Dehydroklaineanone (3) and 15beta-O-acetyl-14-hydroxyklaineanone (6) showed potent plasmodicidal activity (IC(50) = 2 microg/ml). Thus it was suggested that E. longifolia possesses high medicinal values due to the occurrence of a variety of quassinoids.
authors.affiliation: Central Laboratory and Greenhouse Complex, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand. rdiswj@nontri.ku.ac.th
authors.forename: Suratwadee
authors.initials: S
authors.lastname: Jiwajinda
authors.forename: Vilai
authors.initials: V
authors.lastname: Santisopasri
authors.forename: Akira
authors.initials: A
authors.lastname: Murakami
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Monique
authors.initials: M
authors.lastname: Gasquet
authors.forename: Elias
authors.initials: E
authors.lastname: Riad
authors.forename: Guy
authors.initials: G
authors.lastname: Balansard
authors.forename: Hajime
authors.initials: H
authors.lastname: Ohigashi
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D001210:Asia, Southeastern; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D035701:Eurycoma / Q000737:chemistry*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D036702:Quassins / Q000737:chemistry / Q000494:pharmacology*; D012556:Schistosomicides / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects
chemical_list: D016588:Anticarcinogenic Agents; D000962:Antimalarials; D010936:Plant Extracts; D036702:Quassins; D012556:Schistosomicides