Comparative study of two Ginkgo biloba extracts on the phagocytic activity and DTH response of healthy mice.
The phagocytic activity and delayed-type Hypersensitivity (DTH) response to dinitrofluorobenzene (DNFB) of healthy BALB/c mice treated orally (100 mg/kg/day for 7 days) using two Ginkgo biloba extracts were studied. The phytopharmaceuticals Gb 30 (Alban Muller International, France) and EGb 761 (Schwabe, Germany) administered orally stimulated the phagocytic activity of peritoneal and alveolar macrophages. Likewise, the DTH response was found to be increased only with Gb 30 treatment. These results suggest that Ginkgo biloba possesses immunological activity in addition to the biological activity reported. The different chemical concentration of the components of the Ginkgo biloba extracts mentioned above may be responsible for the differences in the observed findings.
Villaseño-García
Maria Martha
MM
Immunopharmacology of Natural Products Laboratory, Biomedical Research Centre in Western Area, IMSS, Guadalajara, Jalisco, Mexico. mmvilla@cucs.udg.mx
Puebla-Pérez
Ana Maria
AM
Lozoya
Xavier
X
D000818:Animals; D004139:Dinitrofluorobenzene / Q000494:pharmacology; D020441:Ginkgo biloba; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000188:drug therapy*; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000502:physiology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use
D010936:Plant Extracts; D004139:Dinitrofluorobenzene