title: A "bad responder" to statins.
abstract: We report the case of a man whose high-density lipoprotein cholesterol (HDL-C) and the ratios of total cholesterol to HDL-C and low-density lipoprotein cholesterol to HDL-C worsened dramatically during pravastatin treatment. After 3 years, pravastatin was replaced by fenofibrate. The result was spectacular. The HDL-C increased to at least twice the level obtained during pravastatin.
authors.affiliation: Department of General Practice, University of Brussels, Laarbeeklaan 103, B-1090 Brussels, Belgium. dirk.devroey@vub.ac.be
authors.forename: Dirk
authors.initials: D
authors.lastname: Devroey
authors.forename: W
authors.initials: W
authors.lastname: Betz
authors.forename: P
authors.initials: P
authors.lastname: Coigniez
authors.forename: R
authors.initials: R
authors.lastname: Lauwers
authors.forename: B
authors.initials: B
authors.lastname: Velkeniers
mesh_terms: D000924:Anticholesteremic Agents / Q000009:adverse effects*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000009:adverse effects*; D017211:Treatment Failure
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017035:Pravastatin