Defolliculated (dfl): a dominant mouse mutation leading to poor sebaceous gland differentiation and total elimination of pelage follicles.
Defolliculated is a novel spontaneous mouse mutation that maps to chromosome 11 close to the type I keratin locus. Histology shows abnormal differentiation of the sebaceous gland, with the sebocytes producing little or no sebum and undergoing abnormal cornification. The hair follicles fail to regress during catagen leading to abnormally long follicles. In contrast the hair shafts are shorter than normal, suggesting altered differentiation or proliferation of matrix cells during anagen. The shafts emerge from the follicle with cornified material still attached. The dermis contains increased numbers of immune cells, including T cells (CD4-positive), macrophages, and mast cells, at all time points examined. Complete elimination of all pelage and tail follicles occurs after two to three hair cycles, apparently by necrosis. Defolliculated may be a useful model for determining further functions of the sebaceous gland, and for understanding the regulation of catagen and hair follicle immunology.
Porter
Rebecca M
RM
Cancer Research UK Cell Structure Research Group, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH, Scotland, U.K. rmporter@dux.dundee.ac.uk
Jahoda
Colin A B
CA
Lunny
Declan P
DP
Henderson
Gayle
G
Ross
Jane
J
McLean
W H Irwin
WH
Whittock
Neil V
NV
Wilson
Neil J
NJ
Reichelt
Julia
J
Magin
Thomas M
TM
Lane
E Birgitte
EB
D000505:Alopecia / Q000235:genetics* / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002875:Chromosomes; D004817:Epidermis / Q000002:abnormalities / Q000276:immunology / Q000473:pathology; D005799:Genes, Dominant; D018859:Hair Follicle / Q000002:abnormalities* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains / Q000002:abnormalities*; D010641:Phenotype; D012627:Sebaceous Glands / Q000002:abnormalities* / Q000276:immunology / Q000473:pathology