Peritoneal infection: a possible redox disease.
In a recent report, pertaining to Bacteroidesfragilis peritonitis, the influence of oxidation-reduction (redox) potential provided experimental evidence for B. fragilis penetration into Hela cell monolayers (using 3D imaging techniques). Bacteria grown under oxidizing conditions (+mV redox) penetrated into tissue cells unlike that of reducing conditions (-mV redox). The present results emphasise the significance of the level of redox potential during infection with an interpretation based on anaerobe/aerobe environmental flux, triggering the invasive mechanism.
Goldner
M
M
Département de biologie médicale, Faculté de Médecine, Université Laval, Québec, Canada.
Grousson
S
S
Jourlin
M
M
D001442:Bacteroides Infections / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D001441:Bacteroides fragilis / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D006367:HeLa Cells; D006801:Humans; D007834:Lasers; D010084:Oxidation-Reduction; D010538:Peritonitis / Q000378:metabolism / Q000382:microbiology*