title: Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship.
abstract: In our endeavor to design and synthesize novel anticancer agents, a new series of indoloquinazoline compounds were prepared and tested initially for anticancer activity in vitro against a panel of human cancer cell lines. Most of these compounds exhibited cytotoxic activity in in vitro screens. Compounds were selected and further evaluated using a modified Hollow Fiber Assay for their preliminary in vivo activity against 12 cell lines implanted in the subcutaneous and intraperitoneal compartments in mice. The results indicate that these compounds may constitute a new class of anticancer agents.
authors.affiliation: Discovery Chemistry (Natural Products), Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India. sarmavm@drreddys.com
authors.forename: Vedula M
authors.initials: VM
authors.lastname: Sharma
authors.forename: P
authors.initials: P
authors.lastname: Prasanna
authors.forename: K V Adi
authors.initials: KV
authors.lastname: Seshu
authors.forename: B
authors.initials: B
authors.lastname: Renuka
authors.forename: C V Laxman
authors.initials: CV
authors.lastname: Rao
authors.forename: G Sunil
authors.initials: GS
authors.lastname: Kumar
authors.forename: C Prasad
authors.initials: CP
authors.lastname: Narasimhulu
authors.forename: P Aravind
authors.initials: PA
authors.lastname: Babu
authors.forename: R C
authors.initials: RC
authors.lastname: Puranik
authors.forename: D
authors.initials: D
authors.lastname: Subramanyam
authors.forename: A
authors.initials: A
authors.lastname: Venkateswarlu
authors.forename: Sriram
authors.initials: S
authors.lastname: Rajagopal
authors.forename: K B Sunil
authors.initials: KB
authors.lastname: Kumar
authors.forename: C Seshagiri
authors.initials: CS
authors.lastname: Rao
authors.forename: N V S Rao
authors.initials: NV
authors.lastname: Mamidi
authors.forename: Dhanvanthri S
authors.initials: DS
authors.lastname: Deevi
authors.forename: R
authors.initials: R
authors.lastname: Ajaykumar
authors.forename: R
authors.initials: R
authors.lastname: Rajagopalan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000737:chemistry; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011799:Quinazolines / Q000737:chemistry; D013329:Structure-Activity Relationship; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011799:Quinazolines; C475704:indolo(2,1-b)quinazoline; C046243:tryptanthrine