Mitotic exit: the Cdc14 double cross.
The release of Cdc14 from the nucleolus occurs in two waves in early and late anaphase, controlled by the FEAR and MEN pathways, respectively. Two new papers report the localisation at the spindle pole body of the Cdc14 released in early anaphase and, surprisingly, show that the two pulses of released Cdc14 have opposite effects on MEN activation.
Geymonat
Marco
M
Division of Yeast Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
Jensen
Sanne
S
Johnston
Leland H
LH
D000705:Anaphase; D018797:Cell Cycle Proteins / Q000502:physiology*; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases; D012441:Saccharomyces cerevisiae / Q000166:cytology; D029701:Saccharomyces cerevisiae Proteins
C074860:CDC14 protein, S cerevisiae; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D017027:Protein Tyrosine Phosphatases