title: Aggressive antihypertensive treatment and serum lipid lowering therapy are necessary to prevent deterioration of the renal function even in elderly type 2 diabetic patients with persistent albuminuria.
abstract: BACKGROUND
  In elderly patients with diabetic nephropathy, clinical information aiming at preventing a decline of the renal function is limited.
  
  
  OBJECTIVE
  To clarify factors that could be related to changes in renal function in elderly diabetic patients with persistent albuminuria.
  
  
  METHODS
  We studied the relationships between the declining rate of creatinine clearance (Ccr) and other clinical features - glycemic control, blood pressure (BP), the degree of albuminuria, and other confounding factors - retrospectively in elderly diabetic patients with persistent albuminuria.
  
  
  RESULTS
  We analyzed 17 elderly diabetic patients with persistent albuminuria (4 men and 13 women, mean age 68.0 +/- 5.7 years at the beginning of the observation period) for 3.7 +/- 1.5 (SD) years. We found that the last value of the urinary albumin excretion (UAE) of the observation period and the individual mean values of systolic BP, mean BP, and serum cholesterol closely correlated with the rate of decline in Ccr estimated by Cockcroft's formula. The last UAE closely correlated with the individual mean values of systolic BP and mean BP. For patients such as the present subjects, adequate retardation of decline in renal function requires that the estimated goal of antihypertensive treatment should be a BP below 130/70 mm Hg. The level of glycemic control and the use of angiotensin-converting enzyme inhibitors did not correlate with the rate of decline in Ccr.
  
  
  CONCLUSIONS
  Aggressive antihypertensive treatment and serum lipid lowering therapy may be necessary to prevent deterioration of the renal function in elderly type 2 diabetic patients with persistent albuminuria.
authors.affiliation: Division of Geriatric Medicine, Akita University Hospital, Akita, Japan. narita@med.akita-u.ac.jp
authors.forename: Takuma
authors.initials: T
authors.lastname: Narita
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kakei
authors.forename: Seiko
authors.initials: S
authors.lastname: Ito
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000150:complications / Q000628:therapy; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000628:therapy*; D006973:Hypertension / Q000150:complications / Q000628:therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007668:Kidney / Q000503:physiopathology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents