title: [Influence of an oscillating physiotherapy device (RC-Cornet trade mark) on the regional distribution of the pulmonary aerosol deposition in patients with COPD].
abstract: BACKGROUND
  The inhalation of ipratropium bromide via a jet nebulizer obtained a significantly higher bronchodilation, if the oscillating physiotherapy device RC-Cornet trade mark was integrated into the exaspiratory limb of the nebulizer. Therefore we investigated the influence of the RC-Cornet trade mark on the central pulmonary radioaerosol deposition as well as the relationship between central and peripheral lung deposition in patients with chronic obstructive lung disease in a controlled study.
  
  
  METHODS
  Lung ventilation scintigraphy was performed routinely in 14 pat. with COPD (Nebulizer: PARI VECTOR trade mark, radioaerosol 500 MBq tin-colloid). At first all pat. inhaled a single breath from the nebulizer, afterwards the lungs were scanned with a planar gamma camera. Both groups (biometric and lung function data were identical) then inhaled another 5 breaths. In group A the RC-Cornet trade mark was inserted into the exaspiratory limb, in group B a normal exaspiratory valve. Once more lung scans were collected. Evaluation of the scans by means of a "region of interest" technique, dividing the lungs in a central and a peripheral area. Measuring of the radioactivity (impulse) per pixel and determination of the penetration index (PI).
  
  
  RESULTS
  The following 5 breaths led to a significant increase of the central aerosol deposition (i. e. decrease of PI) in comparison with the measuring after the first breath in both groups (A 0,41 +/- 0,07 to 0,38 +/- 0,08, p = 0,04; B 0,38 +/- 0,08 to 0,34 +/- 0,11, p = 0,02). However, no difference could be recognized between the groups. No significant difference was seen with respect to the impulses per pixel.
  
  
  CONCLUSIONS
  Neither the aerosol deposition in the central region of the lung nor the relation between central and peripheral deposition (PI) differs between the both groups. The effect of the RC-Cornet trade mark mentioned in the introduction seems to be caused by physiotherapeutic induced changes of the mucus transport and not by an enhanced central drug deposition.
authors.affiliation: Krankenhaus Kloster Grafschaft, Zentrum für Pneumologie, Schlaf- und Beatmungsmedizin, Allergologie, Schmallenberg. p.haidl@t-online.de
authors.forename: P
authors.initials: P
authors.lastname: Haidl
authors.forename: G
authors.initials: G
authors.lastname: Rickert
authors.forename: U H
authors.initials: UH
authors.lastname: Cegla
authors.forename: D
authors.initials: D
authors.lastname: Köhler
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000368:Aged; D001993:Bronchodilator Agents / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage; D008297:Male; D026741:Physical Therapy Modalities; D026761:Physical Therapy Specialty / Q000295:instrumentation / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D009241:Ipratropium