[Chronic bronchial dilatations in different colonies of laboratory rats].
Bronchiectasis occurred naturally in 12-month-old spontaneously diabetic eSS male rats. The lungs of 3 and 6-month-old eSS rats were compared in eumetabolic eSS rats from three inbred lines consisting of inbred spontaneously diabetic eSS derived from IIM strain; these were compared with eumetabolic, outbred Wistar rats, paired by sex and age. Acrylic casts of bronchial tree were obtained after injection of a plastic substance. The casts were pruned to focus on the first four bronchial branchings. Diameter and volume of the conductive bronchial tree were determined using a binocular magnifier. Histological sections were obtained. All lines showed multiple bronchiectasis, mostly fusiform, bronchial dilatation and inflammatory response with lymphocytic infiltrates. These symptoms were much more severe in 180-day-old eSS males. Bacteria were isolated from the lungs in 70% of cases (n = 32), except in eSS rats. Pseudomonas spp. (38%) and Gram-positive cocci as coagulase-negative Staphylococcus spp. (20%) were detected. Neither pathogenic bacteria nor saprophyte fungi were found. Although all lines were affected, diabetes in eSS appears to be an aggravating factor.
Miguel
Juan Carlos
JC
Museo de Anatomía Normal, Facultad de Ciencias Médicas, Rosario, Argentina.
Erazo
Ariana
A
Beduino
Fernanda
F
Picena
Juan Carlos
JC
Luciano
María Isabel
MI
Pizzutti
Gustavo
G
Tarrés
María Cristina
MC
Montenegro
Silvana
S
Martínez
Stella Maris
SM
D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001987:Bronchiectasis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D011549:Pseudomonas / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013210:Staphylococcus / Q000302:isolation & purification