title: Synthesis and antitubercular activity of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazolin-2-one benzylidenehydrazones.
abstract: In this study, a new series of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazoline-2-one benzylidene hydrazones (3a-p) were synthesized. Structures of the title compounds were determined by analytical and spectral methods. 3a-p were evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Beyazit-Istanbul, Turkey. nilgunkarali@yahoo.com
authors.forename: N
authors.initials: N
authors.lastname: Karali
authors.forename: A
authors.initials: A
authors.lastname: Kocabalkanli
authors.forename: A
authors.initials: A
authors.lastname: Gürsoy
authors.forename: O
authors.initials: O
authors.lastname: Ateş
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000995:Antitubercular Agents; D003374:Coumarins; D006835:Hydrazones