Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H(1) receptors.
The purpose of this study was to investigate the involvement of chemical mediators other than histamine in nasal allergic signs using histamine H(1) receptor-deficient mice. In passively sensitized mice, antigen instillation into the nasal cavity induced significant increases in sneezing and nasal rubbing in wild-type mice, but no such increases were observed in histamine H(1) receptor-deficient mice. In actively sensitized mice, both sneezing and nasal rubbing were also significantly increased in a dose-dependent manner in both wild-type and histamine H(1) receptor-deficient mice. Histamine H(1) receptor antagonists such as cetirizine and epinastine significantly inhibited antigen-induced nasal allergic signs in wild-type mice, although the effects were incomplete. In addition, the thromboxane A(2) receptor antagonist ramatroban also inhibited these responses in wild-type mice. However, the leukotriene receptor antagonist zafirlukast showed no effects in wild-type mice. These results suggested that in the acute allergic model (passive sensitization), only histamine H(1) receptors are related to nasal signs induced by antigen, whereas in the chronic allergic model (active sensitization), both histamine H(1) receptors and thromboxane A(2) receptors were involved in the responses.
Kayasuga
Ryoji
R
Department of Pharmacology, Faculty of Pharmaceutical Science, Okayama University, Okayama 700-8530, Okayama, Japan.
Sugimoto
Yukio
Y
Watanabe
Takeshi
T
Kamei
Chiaki
C
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology; D000941:Antigens / Q000276:immunology; D001522:Behavior, Animal / Q000502:physiology; D002227:Carbazoles / Q000494:pharmacology; D017332:Cetirizine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D007202:Indicators and Reagents; D007211:Indoles; D020024:Leukotriene Antagonists / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D048448:Phenylcarbamates; D011969:Receptors, Histamine H1 / Q000235:genetics / Q000502:physiology*; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D012912:Sneezing / Q000502:physiology; D013449:Sulfonamides / Q000494:pharmacology; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors; D014105:Tosyl Compounds / Q000494:pharmacology
D018926:Anti-Allergic Agents; D000941:Antigens; D002227:Carbazoles; D006634:Histamine H1 Antagonists; D007202:Indicators and Reagents; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D011969:Receptors, Histamine H1; D013449:Sulfonamides; D014105:Tosyl Compounds; D007073:Immunoglobulin E; D013928:Thromboxane A2; D010047:Ovalbumin; C063119:ramatroban; C062735:zafirlukast; D017332:Cetirizine