[A linkage analysis of quantitative trait loci for familial schizophrenia on chromosome 1].
OBJECTIVE
To explore the molecular genetic relationship between chromosome 1 and quantitative trait loci for familial schizophrenia.


METHODS
A series of assessment scales included positive and negative syndrome scale (PANSS), global assessment of functional scale (GAFS), premorbid schizoid and schizotypal traits scale (PSST), premorbid social adjustment scale (PSA) were applied to quantify the phenotypes of schizophrenia. Non-parametric linkage analysis of quantitative traits was conducted in 32 multiplex pedigrees with schizophrenia by using 29 microsatellite makers on chromosome 1.


RESULTS
Haseman-Elston   quantitative trait analysis detected a maximum Traditional H-E Lods of 1.73 and a maximum EH H-E Lods of 1.65 of negative symptoms (PANSS-N ) at 147.64 cM, which was overlapped to the positive region of 1q21-23 in qualitative linkage analysis.


CONCLUSIONS
The results suggest there might be an independent quantitative trait locus of negative symptoms on 1q21-23 for familial schizophrenia.
Cai
Guiqing
G
Department of Forensic Medicine, Zhongshan Medical College   Sun Yat-Sen University, Guangzhou, Guangdong, 510080 P.R. China. caiguiqing@163.com
Wu
Xinyao
X
Li
Tao
T
Collier
David A
DA
Liu
Xiehe
X
Feng
Bingjian
B
Deng
Hong
H
Tong
Dayue
D
Li
Jianjin
J
Ou
Jinghua
J
D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005192:Family Health; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats; D019655:Quantitative Trait, Heritable; D012559:Schizophrenia / Q000235:genetics*