The two hats of SOS.
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be recruited to different cellular locations through interactions with the adaptor proteins Grb2 and E3b1.
Nimnual
Anjaruwee
A
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.
Bar-Sagi
Dafna
D
D000818:Animals; D002384:Catalysis; D004789:Enzyme Activation / Q000502:physiology; D006801:Humans; D020837:SOS1 Protein / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D020839:Son of Sevenless Protein, Drosophila / Q000502:physiology; D020664:Son of Sevenless Proteins / Q000502:physiology*
D020837:SOS1 Protein; C485509:SOS2 protein, human; D020839:Son of Sevenless Protein, Drosophila; D020664:Son of Sevenless Proteins