Silica-based artificial protease exploiting aldehyde groups as catalytic elements.
An artificial protease synthesized by covering the surface of silica gel with aldehyde and indole groups effectively hydrolyzed albumin and gamma-globulin. It is proposed that the aldehyde group is involved in both complexation of the protein substrate and the catalytic cleavage of the peptide bonds of the complexed proteins.
Kim
Hyunsook
H
School of Chemistry and Center for Molecular Catalysis, Seoul National University, 151-747, Seoul, Republic of Korea.
Paik
Hyesun
H
Kim
Myoung-soon
MS
Chung
Yeon
Y
Suh
Junghun
J
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D012822:Silicon Dioxide / Q000737:chemistry*
D000447:Aldehydes; D012822:Silicon Dioxide; D010450:Endopeptidases