Conditionally immortalized cell lines as model systems for high-throughput biology in drug discovery.
There is an increasing emphasis on the need for high-quality biological data much earlier in the drug-discovery process. This has led to the development of high-throughput approaches to biology, many of which rely on the use of cell-culture models. Unfortunately, available cell-culture models often reflect poorly the characteristics of the tissue they are supposed to represent. However, the conditional-immortalization approach as applied by Xcellsyz offers the possibility of producing human cell lines on demand, which are truly representative of the tissue from which they derive.
Daniele
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N
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
Halse
R
R
Grinyo
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E
Yeaman
S J
SJ
Shepherd
P R
PR
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D002461:Cell Line, Transformed; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008954:Models, Biological