The effect of plasma caeruloplasmin levels on the sensitivity for activated protein C.
The effect of caeruloplasmin levels on the sensitivity for activated protein C (APC), measured by a clotting assay based on the activated partial thromboplastin time, was investigated in a large group of healthy individuals without factor V Leiden. A modest inverse association between caeruloplasmin and normalized APC sensitivity ratio was found (regression coefficient beta = -0.33 x 10-2; 95% confidence interval, -0.42 x 10-2 to -0.24 x 10-2). After adjustment for sex and oral contraceptive use, this association weakened (beta = -0.19 x 10-2; 95% CI: -0.34 x 10-2 to -0.05 x 10-2). After additional adjustment for factor VIII levels, which are known to influence the assay, the effect of caeruloplasmin on APC sensitivity completely disappeared.
de Visser
Marieke C H
MC
Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, The Netherlands. M.C.H.de_Visser@lumc.nl
Souverijn
John H M
JH
Rosendaal
Frits R
FR
Bertina
Rogier M
RM
D020016:Activated Protein C Resistance / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000032:analysis*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood; D011486:Protein C / Q000378:metabolism; D012016:Reference Values
D003278:Contraceptives, Oral, Hormonal; D011486:Protein C; D005169:Factor VIII; D002570:Ceruloplasmin