New furanoid diterpenes from Caesalpinia pulcherrima.
Four new cassane-type furanoditerpenoids (1-4) were isolated from the air-dried leaves of Caesalpinia pulcherrima. Their structures were elucidated by spectral data interpretation. The exocyclic methylene compound 1 readily isomerized and oxidized to the benzofuran 4. Benzyl 2,6-dimethoxybenzoate (5) was also identified in this study. Antimicrobial tests on 1-5 indicated that they were active against several bacteria (S. aureus, E. coli, P. aeruginosa, and B. subtilis) and fungi (C. albicans and T. mentagrophytes).
Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila, 1004 Philippines. coscyr@mail.dlsu.edu.ph
Consolacion Y
CY
Ragasa
Joy G
JG
Hofileña
John A
JA
Rideout
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D029911:Caesalpinia / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000737:chemistry; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D014249:Trichophyton / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004224:Diterpenes; D005663:Furans; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; C466117:benzyl-2,6-dimethoxybenzoate