Rapid renewal of auditory hair bundles.
Stereocilia, also known as hair bundles, are mechanosensitive organelles of the sensory hair cells of the inner ear that can detect displacements on a nanometre scale and are supported by a rigid, dense core of actin filaments. Here we show that these actin-filament arrays are continuously remodelled by the addition of actin monomers to the stereocilium tips, and that the entire core of the stereocilium is renewed every 48 hours. This unexpected dynamic feature of stereocilia will help our understanding of how auditory sensory function develops and is maintained.
Schneider
Mark E
ME
Belyantseva
Inna A
IA
Azevedo
Ricardo B
RB
Kachar
Bechara
B
D000161:Acoustic Stimulation; D008841:Actin Cytoskeleton / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D002923:Cilia / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D003638:Deafness; D049452:Green Fluorescent Proteins; D006199:Hair Cells, Auditory, Inner / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D009622:Noise / Q000009:adverse effects*; D051381:Rats; D012038:Regeneration
D000199:Actins; D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins