Invasive airway aspergillosis with new airflow obstruction mimicking post-BMT bronchiolitis obliterans.
A 52-year-old male with severe gastrointestinal graft-versus-host disease (GVHD), developed dyspnea and irreversible airflow obstruction, 11 weeks post-allogeneic bone marrow stem cell transplantation. Based on the clinical picture and presence of 'mosaic attenuation' pattern on chest high-resolution computerized tomography (HRCT), he was presumed to have bone marrow transplantation-related bronchiolitis obliterans. Post-mortem examination revealed invasive airway aspergillosis with no evidence of bronchiolitis obliterans.
Institute of Pulmonology, Hadassah University Hospital and Hebrew University-Hadassah School of Medicine, PO Box 12072, Jerusalem, Israel, 91120.
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S
Nusair
G
G
Amir
R
R
Or
R
R
Breuer
D000402:Airway Obstruction / Q000209:etiology*; D001228:Aspergillosis / Q000175:diagnosis / Q000209:etiology*; D001989:Bronchiolitis Obliterans / Q000175:diagnosis; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000628:therapy; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous