Two kinds of endometrial neoplasia arising from different origins in the uterine corpus: comparison of p53 expression and sex steroid receptor status.
This study presents a case of endometrial clear cell adenocarcinoma complicated by complex atypical glandular hyperplasia surrounded by adenomyosis in the uterine myometrium. The former was immuno-negative for estrogen receptor (ER) and positive for p53, whereas both of the latter were immuno-positive for ER and negative for p53. Therefore, there were two kinds of neoplasia arising from different origins in the uterine corpus.
Department of Obstetrics and Gynecology, Himeji National Hospital, 68 Honmachi, Himeji, Hyogo 670-8520, Japan. kosiya@mb.infoweb.ne.jp
Masafumi
M
Koshiyama
Michio
M
Ueta
D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry* / Q000150:complications / Q000473:pathology; D000368:Aged; D004714:Endometrial Hyperplasia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000150:complications / Q000473:pathology; D004715:Endometriosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D011960:Receptors, Estrogen; D016159:Tumor Suppressor Protein p53