[Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction].
OBJECTIVE
To evaluate the effect and mechanism of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction.


METHODS
Twelve dogs were randomly divided into puerarin (Gegen su, G) group and control(C) group, the acute myocardial infarction model was built in all dogs. Puerarin or saline was administered for 21 days. Coronary angiography was performed before and after ligating coronary artery. The capillaries and distribution vessel density in tissue sections of myocardium were assessed.


RESULTS
Angiography on hour 2 and day 22 after ligating coronary artery revealed significant augmentation of collateral vessels in G group versus controls. Capillaries and distribution vessel density in ischemic and infarctive zone on day 22 revealed statistically significant augmentation in G group versus controls (P < 0.05 and P < 0.01).


CONCLUSIONS
Puerarin might improve the opening and forming of coronary collateral circulation to ischemic myocardium in dogs and protect ischemic myocardium.
Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
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Q
Liu
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L
Wang
Z
Z
Lu
S
S
Li
Y
Y
Xiong
D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D014665:Vasodilator Agents / Q000302:isolation & purification / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D007529:Isoflavones; D014665:Vasodilator Agents; C033607:puerarin