The effect of plasma caeruloplasmin levels on the sensitivity for activated protein C.
The effect of caeruloplasmin levels on the sensitivity for activated protein C (APC), measured by a clotting assay based on the activated partial thromboplastin time, was investigated in a large group of healthy individuals without factor V Leiden. A modest inverse association between caeruloplasmin and normalized APC sensitivity ratio was found (regression coefficient beta = -0.33 x 10-2; 95% confidence interval, -0.42 x 10-2 to -0.24 x 10-2). After adjustment for sex and oral contraceptive use, this association weakened (beta = -0.19 x 10-2; 95% CI: -0.34 x 10-2 to -0.05 x 10-2). After additional adjustment for factor VIII levels, which are known to influence the assay, the effect of caeruloplasmin on APC sensitivity completely disappeared.
Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, The Netherlands. M.C.H.de_Visser@lumc.nl
Marieke C H
MC
de Visser
John H M
JH
Souverijn
Frits R
FR
Rosendaal
Rogier M
RM
Bertina
D020016:Activated Protein C Resistance / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000032:analysis*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood; D011486:Protein C / Q000378:metabolism; D012016:Reference Values
D003278:Contraceptives, Oral, Hormonal; D011486:Protein C; D005169:Factor VIII; D002570:Ceruloplasmin