Increasing incidence of candidemia: results from a 20-year nationwide study in Iceland.
A nationwide study on candidemia was conducted in Iceland from 1980 to 1999. The annual incidence increased from 1.4 cases/100,000 inhabitants/year between 1980 and 1984 to 4.9 cases/100,000 inhabitants/year between 1995 and 1999 (P < 0.0001). Candidemia episodes at university hospitals increased from 0.15/1,000 admissions to 0.55/1,000 admissions (P < 0.0001). Candida albicans was the predominant species responsible (64.4%). The national import of fluconazole increased approximately fourfold during the second half of the study, but increased resistance to this agent was not observed.
University of Iceland, Reykjavik, Iceland.
Lena Rós
LR
Asmundsdóttir
Helga
H
Erlendsdóttir
Magnús
M
Gottfredsson
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology; D001769:Blood / Q000382:microbiology; D002175:Candida / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003470:Culture Media; D016469:Fungemia / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D015994:Incidence; D007223:Infant; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
D000935:Antifungal Agents; D003470:Culture Media