Isradipine enhancement of cerebral blood flow in abstinent cocaine abusers with and without chronic perfusion deficits.
Nine cocaine abusers with cerebral blood flow (CBF) deficits (hypo-perfused areas) on HMPAO SPECT scans were compared to six without these deficits after six doses of isradipine (5 mg TID). When comparing the scan before isradipine to that after using SPM analysis, the ratio of hypo- to hyper-fusion showed a 16% increase in the maximum Z scores and 30% fewer areas of hypo-perfusion among those cocaine abusers with deficits. These deficits may represent segmental cerebral vasospasm that was reversed by this vasodilating agent in cocaine abusers with areas of hypo-perfusion (deficits) as baseline.
Department of Psychiatry, Yale University School of Medicine and the VA Connecticut Healthcare System, West Haven, Conn 06516, USA.
P C H
PC
Gottschalk
Thomas R
TR
Kosten
D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D002908:Chronic Disease; D019970:Cocaine-Related Disorders / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D017275:Isradipine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D010091:Oximes; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*
D010091:Oximes; D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; C068296:hexamethylpropyleneamine oxime; D017275:Isradipine