Principles of microbial alchemy: insights from the Streptomyces coelicolor genome sequence.
The world's most creative producers of natural pharmaceutical compounds are soil-dwelling bacteria classified as Streptomyces. The availability of the recently completed Streptomyces coelicolor genome sequence provides a link between the folklore of antibiotics and other bioactive compounds to underlying biochemical, molecular genetic and evolutionary principles.
Biozentrum, University of Basel, Division of Molecular Microbiology, 70 Klingelbergstrasse, 4056 Basel, Switzerland. Charles-J.Thompson@unibas.ch
Charles J
CJ
Thompson
Doris
D
Fink
Liem D
LD
Nguyen
D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D010860:Pigments, Biological / Q000378:metabolism; D013302:Streptomyces / Q000166:cytology / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010860:Pigments, Biological