ABCG4: a novel human white family ABC-transporter expressed in the brain and eye.
White family transporters are a group of ATP-binding cassette (ABC) proteins that show sequence homology to the Drosophila white gene product. The Drosophila protein is a subunit of heterodimeric transporters of precursors for eye-pigment synthesis. A novel, human member of this family (ABCG4) has been identified. Northern blotting shows that ABCG4 is expressed specifically in the brain and the eye.
University Research Centre for Neuroendocrinology, BRI, University of Bristol, Marlborough Street, Bristol BS2 8HW, UK. s.oldfield@bristol.ac.uk
Susan
S
Oldfield
Christopher
C
Lowry
Jon
J
Ruddick
Stafford
S
Lightman
D000070996:ATP Binding Cassette Transporter, Subfamily G; D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis* / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism*; D029721:Drosophila Proteins / Q000737:chemistry; D005123:Eye / Q000378:metabolism*; D005136:Eye Proteins / Q000737:chemistry; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
C439766:ABCG4 protein, human; D000070996:ATP Binding Cassette Transporter, Subfamily G; D018528:ATP-Binding Cassette Transporters; D029721:Drosophila Proteins; D005136:Eye Proteins; C059254:w protein, Drosophila