Hormone profile of Kuwaiti women with hyperemesis gravidarum.
OBJECTIVE
To evaluate the incidence of hyperemesis gravidarum among pregnant women in Kuwait and the status of HCG, TSH, Total T4 and Free T4 in the serum of patients with hyperemesis gravidarum compared with a control group of women.


METHODS
During a 6-month period all patients admitted to Maternity Hospital with features of hyperemesis gravidarum (excessive vomiting and ketonuria) were enlisted into the study. In fifty of these patients and their fifty normal controls, the status of serum total (beta)hCG, TSH, total T4 and freeT4 were evaluated with AXSYM micro particle enzyme immunoassay.


RESULTS
The incidence of hyperemesis in the maternity population was 45 per 1000 deliveries. Total (beta)hCG and Total T4 and FreeT4 were significantly higher in the hyperemesis patients than in the normal controls (p<0.0001, p=0.004 and p=0.01 respectively). TSH levels were significantly lower in hyperemesis patients than in their normal controls (p<0.0001). There was a strong positive correlation between the total (beta)hCG and the gestational age (r=0.8).


CONCLUSIONS
There is a high incidence of hyperemesis gravidarum in the Kuwaiti population. Total (beta)hCG, Total T4 and Free T4 titers were significantly higher in patients with hyperemesis gravidarum, but none of the patients showed signs of hyperthyroidism.
Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Safat. sobha@hsc.kuniv.edu.kw
M
M
Al-Yatama
M
M
Diejomaoh
M
M
Nandakumaran
R A
RA
Monem
A E
AE
Omu
F
F
Al Kandari
D000328:Adult; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D005865:Gestational Age; D006728:Hormones / Q000097:blood*; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood* / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D007730:Kuwait / Q000453:epidemiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D018997:Chorionic Gonadotropin, beta Subunit, Human; D006728:Hormones; D013972:Thyrotropin; D013974:Thyroxine