Efficacy of chamomile-extract spray for prevention of post-operative sore throat.
A randomized, double-blind study was carried out to assess the effect of 111 mg of Chamomile extract spray compared with normal saline spray (placebo) administered before intubation on post-operative sore throat and hoarseness. One hundred and sixty-one ASA (American Society of Anesthesiologists) physical status I, II elective surgical patients were recruited. Forty-two out of 80 patients (52.5%) in the Chamomile group scored no post-operative sore throat in the post-anesthesia care unit compared with 41 out of 81 patients (50.6%) in the placebo group, p=0.159. Post-operative sore throat and hoarseness both in the post-anesthesia care unit and 24 hour after operation were not statistically different. There was no statistically significant relationship between sore throat or hoarseness and ASA physical status, sex, history of smoking, grade of laryngoscopic view, number of intubation attempts, condition during intubation and condition of extubation. However, there was significant correlation between use of oral airway and sore throat in the post-anesthesia care unit and 24 hours after operation (p=0.031 and 0.002 respectively). Chamomile extract spray administered before intubation, therefore, can not prevent post-operative sore throat and hoarseness.
Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Oranuch
O
Kyokong
Somrat
S
Charuluxananan
Vorasri
V
Muangmingsuk
Oraluxna
O
Rodanant
Kaew
K
Subornsug
Wasan
W
Punyasang
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D020843:Chamomile; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D006685:Hoarseness / Q000517:prevention & control; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010612:Pharyngitis / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods; D011322:Primary Prevention / Q000379:methods; D011336:Probability; D012016:Reference Values; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D010936:Plant Extracts