Quantitative EEG changes in Alzheimer patients during long-term donepezil therapy.
Twenty patients affected with probable mild-to-moderate Alzheimer's disease (AD; NINCDS-ADRDA criteria; 14 women and 6 men, mean age 75.2 +/- 7.1 years) who regularly received an oral acetylcholinesterase inhibitor (AChEI; donepezil 5 mg/day; Dz group) were compared with a control group of 11 AD patients (6 women and 5 men, mean age 73.5 +/- 6.0 years) diagnosed and followed up in the pre-AChEIs era (C group). At basal evaluation (t(0)), the 2 groups were comparable for age, education, and severity of disease (Global Deterioration Scale). All patients underwent quantitative EEG (qEEG, average reference, 10-20 International System), and were reexamined about 1 year later (t(1); i.e., after 12.3 +/- 3.6 months the Dz group, and after 13.7 +/- 3.9 months the C group). Log-transformed values of two qEEG bands, i.e. 2-6 and 6.5-12 Hz, were averaged between adjacent channels (frontal F3 and F7, F4 and F8; parietotemporal P3 and T7, P4 and T8) to obtain a qEEG ratio (6.5-12/2-6 Hz.) from one frontal and one temporoparietal region in each hemisphere. Neuropsychological impairment was summarized by the Mini-Mental Status Examination (MMSE). At t(0), both the MMSE score and the qEEG ratio values were somewhat higher in the C than in the Dz group, although nonsignificantly. Between t(0) and t(1), the MMSE score decreased significantly (p < 0.01) more in the C group (-4.36 +/- 2.25) than in the Dz group (-1.45 +/- 2.16), as did the qEEG ratio in the right frontal region (p < 0.01), whereas in the left frontal region the significance level was not reached (p = 0.02). Between t(0) and t(1), the qEEG ratio difference in both frontal regions and in the right temporoparietal region significantly correlated with the MMSE difference (p < 0.01), but neither with time between examinations nor with the difference on the Visual Search Test score. Long-term treatment with Dz led to a lesser deterioration of qEEG, paralleling a milder neuropsychological decline. The effect was significant in frontal regions, possibly because they are relatively spared during the mild-to-moderate phases of the disease.
Clinical Neurophysiology, Department of Internal Medicine, University of Genoa, Genoa, Italy. guido@unige.it
Guido
G
Rodriguez
Paolo
P
Vitali
Caterina
C
De Leo
Fabrizio
F
De Carli
Nicola
N
Girtler
Flavio
F
Nobili
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D000077265:Donepezil; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D007189:Indans / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology*; D011569:Psychiatric Status Rating Scales
D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil