[Antihypertensive study of xingnao qingxuan recipe].
OBJECTIVE
To observe the effect of decreasing blood pressure of Xingnao Qingxuan Casuples.


METHODS
The blood pressure in normal and anesthetised cats was examined with direct method, the blood pressure in the conscious SHR was obtained by indirect method.


RESULTS
Duodenuos administration(id) of XQC of 2.8 g/kg produced a decrease of blood pressure in normal cats; XQC of 1.4, 2.8 and 5.6 g/kg once a day for 14 days produced a dose-dependent reduction of blood pressure in SHR, 3-4 days after administration the blood pressure returned to the level before but the change was not significant. With gastric administration of XQC of 2.8 and 5.6 g/kg for 3 times, the incubation period of eyeball tremor induced by chloroform by dropping into the ear was prolonged by 14.4% and 13.0%, and the keeping time shortened by about 33.3% and 23.3% respectively. Brain basic arterial spasm induced by KCl or 5-HT in dog was relaxed obviously by XQC in vitro experiment.


CONCLUSIONS
XQC has the effect of reducing blood pressure resisting dizziness, which is related to the diastole of brain blood vessel.
National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050.
Y
Y
Zhou
X
X
Hu
Z
Z
Zhao
X
X
He
Q
Q
Peng
X
X
Peng
L
L
Huang
B
B
Sun
R
R
Cao
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001488:Basilar Artery / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002214:Capsules; D002415:Cats; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009759:Nystagmus, Pathologic / Q000188:drug therapy; D010946:Plants, Medicinal; D051381:Rats; D011918:Rats, Inbred SHR; D014661:Vasoconstriction / Q000187:drug effects
D000959:Antihypertensive Agents; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal