Amelioration of relapsing polychondritis in a child treated with oral collagen.
Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a role in the pathogenesis of the disease. RP is so rare that controlled therapeutic trials have not been carried out. We describe herein a child with RP who had amelioration of symptoms and a deviation in the cellular immune response to CII after being treated with daily oral CII as a toleragen.
Navarro
M J
MJ
Department of Pediatrics, University of Tennessee, Memphis, USA.
Higgins
G C
GC
Lohr
K M
KM
Myers
L K
LK
D000284:Administration, Oral; D015551:Autoimmunity; D002648:Child; D024043:Collagen Type II / Q000008:administration & dosage* / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D011081:Polychondritis, Relapsing / Q000188:drug therapy* / Q000276:immunology*; D011347:Procollagen / Q000008:administration & dosage* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome
D024043:Collagen Type II; D016207:Cytokines; D011347:Procollagen