An ESCRT into the endosome.
Multivesicular endosomes sort ubiquitinated membrane proteins for degradation by incorporating them into inwardly budding vesicles. The recent identification of two new oligomeric components of the sorting machinery gives us a detailed view of the complex protein-protein interactions driving this process.
Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Elizabeth
E
Conibear
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000378:metabolism; D021381:Protein Transport; D025801:Ubiquitin / Q000378:metabolism
D002352:Carrier Proteins; D002966:Clathrin; D046911:Macromolecular Substances; D008565:Membrane Proteins; D025801:Ubiquitin