Effects of human recombinant calcitonin on a rat osteopenia model induced by TPTX and arotinoid.
Recombinant human calcitonin (rh-CT) has been developed as an agent for patients with excessive bone resorption to replace calcitonins from animal species, which are associated with tolerance problems. In this study, inhibitory effects of rh-CT against bone resorption were examined in thyroparathyroidectomized (TPTX) rats, the animal model of accelerated bone resorption induced by administering a synthetic retinoid (arotinoid). The arotinoid-treated TPTX rats exhibited signs of stimulated bone resorption, such as hypercalcemia, reduced bone mineral density, and inferior bone strength. Significant improvements were seen in all of these changes after a daily treatment with rh-CT (30, 300 U/kg s.c.) for 1 week. A histomorphometrical analysis showed that the treatment with rh-CT markedly suppressed the reduction of trabecular bone volume and that of cortical thickness in the femur of arotinoid-treated TPTX rats. These results suggest that rh-CT may prevent osteopenia caused by accelerated bone resorption.
Fukuda
C
C
Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Oizumi
K
K
Ohhata
K
K
Kiyokawa
A
A
Katsumata
M
M
Ishikawa
H
H
Miyamoto
M
M
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000652:urine; D004195:Disease Models, Animal; D006801:Humans; D006934:Hypercalcemia / Q000503:physiopathology*; D016105:Parathyroidectomy; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D012176:Retinoids / Q000494:pharmacology*; D013965:Thyroidectomy
D011994:Recombinant Proteins; D012176:Retinoids; D002116:Calcitonin; D002118:Calcium