Identification of the Xenopus laevis cDNA for EXT1: a phylogenetic perspective.
The EXT family of genes is involved in the developmentally important biosynthesis of heparan sulfate molecules. Members of the EXT family have a demonstrated role in gastrulation, wing formation in flies, and proper bone development in vertebrates. EXT family members have been isolated from several phylogenetically diverse species. We report here, the isolation of the first Xenopus laevis EXT1 family member and discuss the evolutionary origins of this gene family.
Biology Department, Bannow Science Center, Fairfield University, North Benson Road, Fairfield, CT 06430-5195, USA. ahill@fair1.fairfield.edu
A L
AL
Hill
N
N
Brown
M S
MS
Hill
D E
DE
Wells
D000595:Amino Acid Sequence; D000818:Animals; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics*; D010802:Phylogeny; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D014982:Xenopus laevis; D000099058:Exostosin 1
D018076:DNA, Complementary; D017351:N-Acetylglucosaminyltransferases; D000099058:Exostosin 1