Distribution of kerosene components in rats following dermal exposure.
The systemic distribution of kerosene components in blood and tissues was analysed in rats following dermal exposure. Four types of trimethylbenzenes (TMBs) and aliphatic hydrocarbons (AHCs) with carbon numbers 9-16 (C(9)-C(16)) were analysed as major kerosene components by capillary gas chromatography/mass spectrometry (GC/MS). The kerosene components were detected in blood and all tissues after a small piece of cotton soaked with kerosene was applied to the abdominal skin. The amounts of TMBs detected were higher than those of AHCs. Greater increases in TMB levels were found in adipose tissue in an exposure duration-dependent manner. The amounts of TMBs detected were only at trace levels following post-mortem dermal exposure to kerosene. These findings suggest that kerosene components were absorbed percutaneously and distributed to various organs via the blood circulation. Post-mortem or ante-mortem exposure to kerosene could be distinguished when the exposure duration was relatively long. Adipose tissue would seem to be the most useful for estimating the degree of kerosene exposure.
Department of Dermatology, Shimane Medical University, 89-1 Enya, Izumo, Shimane 693-8501, Japan.
Y
Y
Tsujino
Y
Y
Hieda
K
K
Kimura
H
H
Eto
T
T
Yakabe
K
K
Takayama
S
S
Dekio
D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D006838:Hydrocarbons / Q000032:analysis / Q000493:pharmacokinetics*; D007648:Kerosene / Q000032:analysis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption; D014018:Tissue Distribution
D006838:Hydrocarbons; D007648:Kerosene