Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas.
[reaction: see text] Microwave-assisted O-alkylations of several carboxylic acids have been performed with three different O-alkylisoureas. All reactions are significantly faster compared to conventionally heated reactions, while retaining high chemoselectivity. The combination of microwave technology with the use of the solid-supported isourea 3 enables the synthetic chemist to obtain the pure methyl esters starting from the corresponding acids in less than an hour.
Combinatorial Centre of Excellence, Chemistry Department, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Stefano
S
Crosignani
Peter D
PD
White
Bruno
B
Linclau