A general, norbornyl based approach to anti-Bredt alkenes via sequential RCM-fragmentation strategy.
A general protocol for the synthesis of bicyclo[n.3.1]frameworks with bridgehead double bond (anti-Bredt alkenes), from a common, readily available norbornyl precursor, involving sequential ring closure metathesis (RCM) and Wharton fragmentation is outlined.
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.
Goverdhan
G
Mehta
R Senthil
RS
Kumaran