New furanoid diterpenes from Caesalpinia pulcherrima.
Four new cassane-type furanoditerpenoids (1-4) were isolated from the air-dried leaves of Caesalpinia pulcherrima. Their structures were elucidated by spectral data interpretation. The exocyclic methylene compound 1 readily isomerized and oxidized to the benzofuran 4. Benzyl 2,6-dimethoxybenzoate (5) was also identified in this study. Antimicrobial tests on 1-5 indicated that they were active against several bacteria (S. aureus, E. coli, P. aeruginosa, and B. subtilis) and fungi (C. albicans and T. mentagrophytes).
Ragasa
Consolacion Y
CY
Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila, 1004 Philippines. coscyr@mail.dlsu.edu.ph
Hofileña
Joy G
JG
Rideout
John A
JA
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D029911:Caesalpinia / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000737:chemistry; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D014249:Trichophyton / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004224:Diterpenes; D005663:Furans; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; C466117:benzyl-2,6-dimethoxybenzoate