A graft-versus-tumor effect in a patient with ependymoma who received an allogenic bone marrow transplant for therapy-related leukemia. Case report.
Graft-versus-leukemia effect is an immune-mediated antitumor phenomenon associated with allogenic bone marrow transplants (BMTs) for hematological malignancies, and recent findings have indicated that a similar effect could occur in some solid tumors such as breast cancers. The authors report on a 42-year-old man with a recurrent ependymoma who received an allogenic BMT for therapy-related leukemia. After transplantation, the patient developed chronic graft-versus-host disease, which was controlled with steroid agents. Interestingly, the recurrent ependymoma regressed steadily over the next 21 months posttransplant, until the tumor became almost undetectable on magnetic resonance images. This case indicates that the graft-versus-tumor effect, mediated by cytotoxic T cells, may be able to target intraparenchymal neuroepithelial tumors, despite the brain's generally recognized status as an immunoprivileged organ.
Tanaka
Minoru
M
Division of Neurosurgery, National Cancer Center Hospital, Tokyo, Japan. mntanaka-nsu@umin.ac.jp
Shibui
Soichiro
S
Kobayashi
Yukio
Y
Nomura
Kazuhiro
K
Nakanishi
Yukihiro
Y
D000328:Adult; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D004806:Ependymoma / Q000503:physiopathology* / Q000532:radiotherapy*; D020350:Graft vs Tumor Effect / Q000502:physiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D007953:Leukemia, Radiation-Induced / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D008297:Male