Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever.
A 14-year-old girl was seen at a community clinic with a chief complaint of abdominal pain and fevers and was treated with oral ciprofloxacin for presumed pyelonephritis. She became tachycardic and hypotensive after her first dose of antibiotic, and she developed disseminated intravascular coagulation. She was admitted to our hospital for presumed sepsis. Her outpatient peripheral blood smear was reviewed, revealing spirochetes consistent with Borrelia sp. To our knowledge this is the first reported case of the Jarisch-Herxheimer reaction to ciprofloxacin.
Webster
Gregory
G
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
Schiffman
Joshua D
JD
Dosanjh
Amarjit S
AS
Amieva
Manuel R
MR
Gans
Hayley A
HA
Sectish
Theodore C
TC
D000293:Adolescent; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001898:Borrelia / Q000302:isolation & purification; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D004318:Doxycycline / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012061:Relapsing Fever / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D012772:Shock, Septic / Q000209:etiology
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D004318:Doxycycline