Growth of rotaviruses in primary pancreatic cells.
Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.
Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010, Australia. barbarac@unimelb.edu.au
Barbara S
BS
Coulson
Paul D
PD
Witterick
Yan
Y
Tan
Marilyn J
MJ
Hewish
Joanne N
JN
Mountford
Leonard C
LC
Harrison
Margo C
MC
Honeyman
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D006801:Humans; D007515:Islets of Langerhans / Q000821:virology*; D008251:Macaca; D051379:Mice; D016688:Mice, Inbred NOD; D010179:Pancreas / Q000166:cytology / Q000821:virology*; D012401:Rotavirus / Q000254:growth & development*; D013552:Swine; D014779:Virus Replication