Effects of inhaled 1-bromopropane vapor on rat metabolism.
Wistar male rats were exposed to 1-bromopromane (1-BP) vapor for 6 h a day, 5 days a week, for 3 and 4 weeks (1500 ppm) and 1 day, and 4 and 12 weeks (700 ppm). After the exposures, 1-BP and its metabolites were measured temporally. In the samples obtained from the 700 ppm exposures, hematological and biochemical examinations in blood and measurements of hepatic cytochromes P450 were carried out. 1-BP in blood decreased rapidly to the detection limit within 0.7 h. On the other hand, bromine ion persisted longer in both blood and urine; the biological half-life of bromine ion was 4.7-15.0 days in blood and 5.0-7.5 days in urine. Glycidol was detected in the urine samples. Based on the experimental results, the metabolic pathway of 1-BP was discussed. Hepatic cytochromes P450, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in blood decreased significantly with 1-BP exposure, but other enzyme activities did not differ significantly.
Department of Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
Toru
T
Ishidao
Naoki
N
Kunugita
Yukiko
Y
Fueta
Keiichi
K
Arashidani
Hajime
H
Hori
D000280:Administration, Inhalation; D000410:Alanine Transaminase / Q000096:biosynthesis / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000096:biosynthesis / Q000097:blood; D019963:Clinical Chemistry Tests; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D006403:Hematologic Tests; D006842:Hydrocarbons, Brominated / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014835:Volatilization
D006842:Hydrocarbons, Brominated; D003577:Cytochrome P-450 Enzyme System; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C118559:1-bromopropane