Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.
Subtilisin/kexin isozyme-1 (SKI-1), otherwise known as Site-1 protease (S1P), is a Golgi proteinase mediating the proteolytic activation of the precursor to sterol-regulated element-binding proteins (SREBPs) 1 and 2, two transcriptional factors that regulate expression of a variety of genes involved in cholesterol and lipid metabolism. Using PCR and RFLP analysis on a panel of genomic DNA from a mouse intersubspecific back-cross, we have mapped the SK1-/S1P gene (locus symbol: Mbtps1) to the distal part of mouse chromosome 8, in a region that exhibits synteny homology to the human chromosome 16q24 region where its orthologue had been previously mapped.
Diseases of Aging Program, Ottawa Health Research Institute, University of Ottawa, 725 Parkdale Avenue, Ottawa, Ont., Canada K1Y 4K9.
Haidy
H
Tadros
Nabil G
NG
Seidah
Michel
M
Chrétien
Majambu
M
Mbikay
D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D051379:Mice; D043484:Proprotein Convertases; D012697:Serine Endopeptidases / Q000235:genetics*; D026801:Synteny
D043484:Proprotein Convertases; D012697:Serine Endopeptidases; C115575:membrane-bound transcription factor peptidase, site 1