Anticipatory evolution and DNA shuffling.
DNA shuffling has proven to be a powerful technique for the directed evolution of proteins. A mix of theoretical and applied research has now provided insights into how recombination can be guided to more efficiently generate proteins and even organisms with altered functions.
Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.
Jamie M
JM
Bacher
Brian D
BD
Reiss
Andrew D
AD
Ellington
D004247:DNA / Q000235:genetics*; D019143:Evolution, Molecular; D011995:Recombination, Genetic / Q000235:genetics*
D004247:DNA