Bilateral fronto-occipital polymicrogyria and epilepsy.
We present a clinico-pathological case report in which both cortical dysplasia and epilepsy coexisted: a 30 year old male who was dead on arrival at hospital. One and a half hours earlier he had developed complex partial status with peri-oral cyanosis. At post mortem examination his brain showed bilateral occipital frontal polymicrogyria with unlayered neuronal migration disorder; in other parts there were fourth layer migration disorders. The white matter exhibited multicystic encephalopathy. In the heart there was chronic interstitial and perivascular fibrosis, although he died of a cardiac arrest. Bilateral frontal-occipital polymicrogyria is highly epileptogenic. This was a sporadic case and we cannot define a clear aetiology. There was a pathological cardiac condition without previous vascular risk factors which might be related to repetition of seizures and possibly to his sudden death during status epilepticus.
Ribacoba Montero
R
R
Unit of Neurology, H. Alvarez Buylla, Mieres, Asturias, Spain. rribacobam@meditex.es
Garcia Pravia
C
C
Astudillo
A
A
Salas Puig
J
J
D000328:Adult; D003645:Death, Sudden; D004827:Epilepsy / Q000175:diagnosis*; D017809:Fatal Outcome; D005625:Frontal Lobe / Q000002:abnormalities* / Q000473:pathology; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000002:abnormalities* / Q000473:pathology