Intramembrane proteolysis controls diverse signalling pathways throughout evolution.
Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.
MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK. sin@mrc-lmb.cam.ac.uk
Sinisa
S
Urban
Matthew
M
Freeman
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002450:Cell Communication; D002467:Cell Nucleus / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism; D003593:Cytoplasm / Q000502:physiology; D010450:Endopeptidases / Q000378:metabolism*; D019143:Evolution, Molecular; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D009097:Multienzyme Complexes; D014157:Transcription Factors; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex