BNAs: novel nucleic acid analogs with a bridged sugar moiety.
This article deals with our recent studies on the synthesis of BNAs (Bridged Nucleic Acids), novel nucleic acid analogs bearing a preorganized sugar conformation by a bridged structure. Duplex- and triplex-forming abilities of the BNA modified oligonucleotides are also described.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. imanishi@phs.osaka-u.ac.jp
Takeshi
T
Imanishi
Satoshi
S
Obika
D020029:Base Pairing; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020319:Oligodeoxyribonucleotides, Antisense / Q000737:chemistry; D010429:Pentoses / Q000138:chemical synthesis* / Q000737:chemistry
D019086:Bridged Bicyclo Compounds, Heterocyclic; D009696:Nucleic Acids; D020319:Oligodeoxyribonucleotides, Antisense; D010429:Pentoses