Measurement of enantiomeric excess using molecularly imprinted polymers.
[reaction: see text] A new method is presented for the measurement of enantiomeric excess (ee) utilizing molecularly imprinted polymers (MIPs). The method is demonstrated to be accurate and rapid, as the ee values can be calculated from straightforward concentration measurements. The MIP-based assay can also be adapted to measure the ee of samples of differing initial concentrations.
University of South Carolina, Department of Chemistry and Biochemistry, Columbia, South Carolina 29208, USA.
Yizhao
Y
Chen
Ken D
KD
Shimizu
D001665:Binding Sites; D002138:Calibration; D002846:Chromatography, Affinity; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism
D011108:Polymers; C060198:phenylalanine anilide; D010649:Phenylalanine