The hepatic immune system.
The liver regulates T-cell homeostasis, induces T-cell tolerance, and supports intrahepatic T-cell responses against hepatotropic pathogens. Many data from clinical and preclinical systems provide supportive evidence for these diverse roles of the liver in modulating peripheral (systemic, mucosal, and intrahepatic) T-cell immunity. Little information is available on the cellular and molecular mechanisms that mediate the dual role of the liver in tolerizing T-cell responses and in supporting intrahepatic priming of T-cell responses. Understanding these immunoregulatory effects in the liver may offer insight into clinically relevant immunopathologies of this organ.
Wick
Mary Jo
MJ
Department of Clinical Immunology, University of Göteborg, Sweden.
Leithäuser
Frank
F
Reimann
Jörg
J
D017951:Antigen Presentation; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology*; D006505:Hepatitis / Q000276:immunology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000276:immunology*; D017634:Self Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*