Haemophilus influenzae type b vaccine formulation and risk of childhood leukaemia.
Incidence of childhood leukaemia was studied among subjects of a vaccine trial in Finland comparing the polysaccharide-diptheria toxoid conjugate and oligosaccharide-CRM197 conjugate Haemophilus influenzae type b conjugate vaccine formulations. Eighty cases of childhood leukaemia were detected: 35 among children on the polysaccharide-diptheria toxoid conjugate arm, and 45 among children on the oligosaccharide-CRM197 conjugate arm, which was not statistically significant.
Groves
F
F
Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, SC 29425-0835, USA. grovesf@musc.edu
Sinha
D
D
Auvinen
A
A
D000293:Adolescent; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D018073:Haemophilus Vaccines / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D009313:National Health Programs / Q000706:statistics & numerical data; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000209:etiology; D011446:Prospective Studies; D012306:Risk; D013745:Tetanus Toxoid / Q000009:adverse effects*; D014611:Vaccination / Q000009:adverse effects; D018074:Vaccines, Conjugate / Q000009:adverse effects
D001426:Bacterial Proteins; D018073:Haemophilus Vaccines; C055753:Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate; C028581:CRM197 (non-toxic variant of diphtheria toxin); C061963:HibTITER protein, Haemophilus influenzae