Hyperpigmentation due to pyrimethamine use.
Pyrimethamine is used for the treatment of toxoplasmosis and the prophylaxis of malaria. Among the well-documented side effects are megaloblastic anemia, leukopenia, thrombopenia, rash, vomiting, and diarrhea. Hyperpigmentation is a very rare side effect. In some patients, associated HIV infection makes it difficult to distinguish the reasons for the etiology. We herein describe an HIV-negative patient who developed hyperpigmentation after pyrimethamine use.
Department of Clinical Bacteriology and Infectious Diseases, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
Recep
R
Ozturk
Aynur
A
Engin
Resat
R
Ozaras
Ali
A
Mert
Fehmi
F
Tabak
Yildirim
Y
Aktuğlu
D000328:Adult; D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D018023:HIV Seronegativity; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D011739:Pyrimethamine / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D014123:Toxoplasmosis / Q000175:diagnosis / Q000188:drug therapy
D000981:Antiprotozoal Agents; D011739:Pyrimethamine