Dehydroepiandrosterone sulfate and growth axis hormones in patients after surgery.
We selected 38 patients scheduled for cholecystectomy and studied their serum concentrations of dehydroepiandrosterone (DHEA) and growth axis hormones [growth hormone/insulin-like growth factor-1 (GH/IGF-1)]. We aimed to determine whether alterations in these concentrations resulted from surgical stress or, on the contrary, preceded surgery and were themselves a cause of chronic diseases that reduce life expectancy. We measured the serum concentrations of DHEA sulfate (DHEA-S), ACTH, cortisol, human GH (hGH), IGF-1, and IGF-1 binding protein-3 (IGFBP-3) preoperatively and then 2 and 7 days after surgery; we also compared the preoperative findings with those of a healthy control group. The results were analyzed by gender because DHEA and GH/IGF-1 are known to present sexual dimorphism. There were no significant differences between the preoperative and control results for any of the parameters studied. We found a significant reduction in the concentrations of DHEA-S and IGF-1 on days 2 and 7 after surgery versus the preoperative values. We conclude that the decrease in DHEA-S in patients after surgery is a result of surgical trauma and does not precede surgical stress. The decrease in hormone levels observed in patients with chronic disease may therefore be a result, not a cause, of disease, as some have claimed. Further studies with a later endpoint would be of interest to assess any subsequent return of DHEA-S levels to baseline measurements.
Department of Biochemistry and Molecular Biology, Clinico Hospital, University of Granada, Avenida de Madrid s/n, 180012 Granada, Spain.
Alvaro
A
Osorio
Rafael
R
Vara-Thorbeck
Jorge
J
Rosell
Carlos
C
Osorio
Esperanza
E
Ortega
Estrella
E
Ruiz-Requena
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000097:blood* / Q000601:surgery; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D013312:Stress, Physiological / Q000097:blood*
D019382:Human Growth Hormone; D019314:Dehydroepiandrosterone Sulfate; D007334:Insulin-Like Growth Factor I; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone