[Mechanisms of radio-induced apoptosis].
A general overview of the activation mechanisms of programmed cell death or apoptosis following an irradiation is given in this review. First, are summarized the main induction pathways of radiation-induced apoptosis by which extracellular (tumor necrosis factor (TNF), Fas ligand, TNF-related apoptosis-inducing ligand (TRAIL)) and intracellular (mitochondria and caspases) signals are integrated. A second part is then devoted to the importance of p53 and of its regulators (ATR, ATM, DNA-PKcs) in the process of radiation-induced apoptosis. Thereafter, signal transduction pathways and more specially the role of some protein kinases (MEKK, SAPK/JNK, p38-MAPK) is treated. At last, a chapter concerns the clinical interest of radiation-induced apoptosis and the implication of apoptosis in the treatment of certain diseases.
Laboratoire de Radiobiologie, Centre d'Etude de l'Energie Nucléaire, SCK-CEN, Mol, Belgique. sbaatout@sckcen.be
Sarah
S
Baatout
Hanane
H
Derradji
Olivier
O
Petitfour
Hanna
H
von Suchodoletz
Max
M
Mergeay
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D006801:Humans; D011878:Radiotherapy; D015398:Signal Transduction / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000528:radiation effects
D016159:Tumor Suppressor Protein p53