Residue study of ivermectin in plasma, milk, and mozzarella cheese following subcutaneous administration to buffalo (Bubalus bubalis).
The distribution of ivermectin in buffalo plasma and milk after administration of a single subcutaneous dose (0.2 mg kg(-)(1) b.w.) was studied. Ivermectin reached the maximal concentration in plasma (28.5 +/- 1.7 ng mL(-)(1)) and milk (23.6 +/- 2.6 ng mL(-)(1)) after 2.4 +/- 0.32 and 2.8 +/- 0.44 days, respectively. The drug showed a parallel disposition in milk and plasma, with a ratio of 1.12 +/- 0.16. Ivermectin concentrations were detected in mozzarella cheese obtained from milk collected on days 1, 3, 4, and 20 following administration. The highest values (81.4 +/- 3.26 ng g(-)(1)) were found in the cheese produced on day 3 and were 4-fold higher than those present in the milk.
Dipartimento of Scienze Zootecniche e Ispezione degli Alimenti, Facoltá di Medicina Veterinaria, Universitá degli Studi di Napoli, Federico II, Via F. Delpino, 1, Italy. anastasi@unina.it
Aniello
A
Anastasio
Mauro
M
Esposito
Michele
M
Amorena
Paolo
P
Catellani
Luigi
L
Serpe
Maria Luisa
ML
Cortesi
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D002020:Buffaloes; D002611:Cheese / Q000032:analysis*; D005260:Female; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007700:Kinetics; D008892:Milk / Q000737:chemistry*
D000871:Anthelmintics; D007559:Ivermectin