The prognostic value of a single hepatitis C virus RNA load measurement taken early after human immunodeficiency virus seroconversion.
Hepatitis C virus (HCV) RNA loads are measured sporadically in HCV-positive individuals. However, the prognostic value of these isolated measurements for predicting progression to acquired immune deficiency syndrome (AIDS) and all-cause mortality in coinfected individuals remains unclear. In this study, the prognostic value of a single HCV RNA load measurement taken early after human immunodeficiency virus (HIV) seroconversion was investigated in a cohort of 96 male patients with inherited bleeding disorders. Dates of HIV seroconversion had been estimated for all patients, and at least 4 HCV RNA load measurements per patient were done retrospectively after HIV seroconversion. HCV RNA load stabilized at 4 years after HIV seroconversion, and this point was used for analysis. There was a significant correlation between increased age and early HCV RNA load (r=0.25; P=.01). Adjusting for HIV RNA levels, CD4 cell counts, and the age effect, HCV RNA load >5.90 log(10) copies/mL was predictive of progression to AIDS and all-cause mortality over a period of at least 15 years.
Department of Virology, Royal Free and University College Medical School, Royal Free Hospital, London, United Kingdom. e.herrero@rfc.ucl.ac.uk
Esteban
E
Herrero-Martínez
Caroline A
CA
Sabin
Jamie G
JG
Evans
Anja
A
Griffioen
Christine A
CA
Lee
Vincent C
VC
Emery
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005838:Genotype; D006679:HIV Seropositivity / Q000150:complications* / Q000503:physiopathology*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology; D006467:Hemophilia A / Q000150:complications*; D016174:Hepacivirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012367:RNA, Viral / Q000097:blood*; D019562:Viral Load
D012367:RNA, Viral