A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis.
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Paul N
PN
Newton
Le Hung
le H
Thai
Nguyen Quoc
NQ
Tip
Jennifer M
JM
Short
Wirongrong
W
Chierakul
Adul
A
Rajanuwong
Punnee
P
Pitisuttithum
Sanchai
S
Chasombat
Benjaluck
B
Phonrat
Wirach
W
Maek-A-Nantawat
Reungsilp
R
Teaunadi
David G
DG
Lalloo
Nicholas J
NJ
White
D000086:Acetazolamide / Q000627:therapeutic use*; D000138:Acidosis / Q000209:etiology; D000284:Administration, Oral; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000188:drug therapy; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D019586:Intracranial Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged
D000935:Antifungal Agents; D004232:Diuretics; D000666:Amphotericin B; D000086:Acetazolamide