Bone and ceramic interaction in the bone union process.
This study applied an experimental rat model and ceramic as an artificial matrix to explore the ultrastructural development of new bone production in tibia defects. By X-ray diffraction control or energy-dispersive X-ray analysis the nature of ceramic was verified and routine histology and TEM investigation were used to demonstrate bone - ceramic interaction. The results show that biphasic ceramic can promote bone growth in an osseous defect and is therefore an alternative to autogenous bone matrix. The porousity and bioactivity of the biphasic ceramic enhanced bone formation and provided a scaffold for new lamellar bone invasion.
Department of Orthopedics, University Hospital Tzaritza Ioannina, Sofia, Bulgaria. ltzvetanov@yahoo.com
Lubomir
L
Tzvetanov
Sasha
S
Nikolaeva
Ivan
I
Michailov
Petar
P
Tivchev
D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002516:Ceramics; D005260:Female; D008854:Microscopy, Electron; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis; D051381:Rats; D013977:Tibia / Q000293:injuries* / Q000648:ultrastructure*
D018786:Bone Substitutes