Acute and subacute nephrotoxicity of 2-bromophenol in rats.
The present report aims at providing broader information on the acute nephrotoxicity of 2-bromophenol (2-BP) (a bromobenzene (BB) metabolite), due to its action on the kidneys, after repeated administration. Investigations were performed on female rats. Following a single dose, the most pronounced changes involved: concentrations and rates of excretion of proteins in urine, the number of epithelial cells excreted in urine, creatinine and urea clearance and reduced glutathione in renal tissue. Immediate effects could be ascribed to both renal tubules and glomeruli, mirrored in the level of urinary proteins and intensified excretion of renal epithelial cells. Less pronounced changes of the indicator values were noted under repeated dosing of 2-BP. The results obtained in a single exposure study confirm earlier reports on the mild nephrotoxicity of 2-BP following exposure to high doses. However, the transition from single to repeated exposure does not result in enhanced nephrotoxicity.
Department of Toxicology, Faculty of Pharmacy, Medical University, Muszynskiego 1, 90-151 Lodz, Poland. ebruchajzer@pharm.am.lodz.pl
Elzbieta
E
Bruchajzer
Jadwiga A
JA
Szymanska
Jerzy K
JK
Piotrowski
D000284:Administration, Oral; D000818:Animals; D021461:Animals, Outbred Strains; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity*; D011507:Proteinuria; D051381:Rats; D014508:Urea / Q000378:metabolism
D010636:Phenols; D014508:Urea; C032038:2-bromophenol; D003404:Creatinine; D005978:Glutathione