Bilateral fronto-occipital polymicrogyria and epilepsy.
We present a clinico-pathological case report in which both cortical dysplasia and epilepsy coexisted: a 30 year old male who was dead on arrival at hospital. One and a half hours earlier he had developed complex partial status with peri-oral cyanosis. At post mortem examination his brain showed bilateral occipital frontal polymicrogyria with unlayered neuronal migration disorder; in other parts there were fourth layer migration disorders. The white matter exhibited multicystic encephalopathy. In the heart there was chronic interstitial and perivascular fibrosis, although he died of a cardiac arrest. Bilateral frontal-occipital polymicrogyria is highly epileptogenic. This was a sporadic case and we cannot define a clear aetiology. There was a pathological cardiac condition without previous vascular risk factors which might be related to repetition of seizures and possibly to his sudden death during status epilepticus.
Unit of Neurology, H. Alvarez Buylla, Mieres, Asturias, Spain. rribacobam@meditex.es
R
R
Ribacoba Montero
C
C
Garcia Pravia
A
A
Astudillo
J
J
Salas Puig
D000328:Adult; D003645:Death, Sudden; D004827:Epilepsy / Q000175:diagnosis*; D017809:Fatal Outcome; D005625:Frontal Lobe / Q000002:abnormalities* / Q000473:pathology; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000002:abnormalities* / Q000473:pathology