New developments in chemical library synthesis. Norbornenyl tags for use in phase-switching, sequestration, capture-release and soluble support applications.
A new, general chemical library purification platform is reviewed. This platform makes broad use of (oxa)norbornenyl-tagged reactants, reagents, catalysts, sequestration-enabling reagents and scavengers, in combination with Grubbs catalyst-mediated ring-opening metathesis polymerization (ROMP) reactions as an in situ polymerization purification technique. Extensions of this platform involve the use of preformed ROMP supports in synthesis, and polystyrene-supported Grubbs catalysts, which perform in a boomerang fashion.
Flynn
Daniel L
DL
NeoGenesis Pharmaceuticals Inc, 840 Memorial Drive, Cambridge, MA 02139, USA. dflynn@neogenesis.com
Hanson
Paul R
PR
Berk
Scott C
SC
Makara
Gergely M
GM
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D015195:Drug Design; D006801:Humans; D007202:Indicators and Reagents; D009636:Norbornanes / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends
D007202:Indicators and Reagents; D009636:Norbornanes