Two new minor polybrominated dibenzo-p-dioxins from the marine sponge Dysidea dendyi.
Two new minor tribromodibenzo-p-dioxins, spongiadioxin C (1) and its methyl ether (2), were isolated from an Australian marine sponge Dysidea dendyi, together with the known minor metabolites methyl ethers of spongiadioxins A (4) and B (6) and polybrominated diphenyl ethers (7-9). The structures of the new compounds were established by 1D and 2D NMR spectroscopy and confirmed by synthesis of 2 from diphenyl ether 9. All isolated compounds inhibited the cell division of fertilized sea urchin eggs.
Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok, Russia. utkinan@mail.ru
Natalia K
NK
Utkina
Vladimir A
VA
Denisenko
Marina V
MV
Virovaya
Olga V
OV
Scholokova
Nina G
NG
Prokof'eva
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004147:Dioxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004531:Eggs; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008745:Methylation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010647:Phenyl Ethers; D011161:Porifera / Q000737:chemistry*; D012617:Sea Urchins / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization
D004147:Dioxins; D006842:Hydrocarbons, Brominated; D010647:Phenyl Ethers; C433568:spongiadioxin A; C433569:spongiadioxin B; C466698:spongiadioxin C; C466699:spongiadioxin C, methyl ether; C031538:phenyl ether