B-cell development and antigen receptor signalling.
B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis. At the molecular level, Vav proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux.
Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. martin.turner@bbsrc.ac.uk
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D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D018797:Cell Cycle Proteins; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D015513:Oncogene Proteins / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000235:genetics / Q000276:immunology; D051567:Proto-Oncogene Proteins c-vav; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D018797:Cell Cycle Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D011947:Receptors, Antigen, B-Cell; C496618:VAV1 protein, human; C093651:VAV2 protein, human; C496619:Vav1 protein, mouse; C490565:Vav2 protein, mouse