Basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy.
OBJECTIVE
To investigate the presence of basic fibroblast growth factor (bFGF), glutamine synthetase (GS), and interleukin-6 (IL-6) in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy (PVR).


METHODS
Comparative case series; experimental study.


METHODS
In a prospective study, we measured bFGF, GS, IL-6, and total protein in vitreous fluid samples from 53 eyes from 53 consecutive patients with PVR operated on in our hospital. As controls, vitreous fluid samples from eyes with a macular hole (n = 9) or pucker (n = 11) were used.


METHODS
Laboratory data of the patient group were compared with the control group and correlated with various clinical data, especially with visual recovery and redetachment.


RESULTS
For IL-6, bFGF, and total protein we found significantly higher levels in PVR patients' eyes than in control eyes (P =.03, P =.046, and P <.0001, respectively). Within the PVR group, no significant correlation was found for IL-6, bFGF, GS, or total protein with the various tested clinical variables.


CONCLUSIONS
We found increased levels of IL-6, bFGF, and total protein in vitreous fluid from patients' eyes with PVR. Whether the increased levels of IL-6, bFGF, and total protein are the result of an injury-induced upregulation of these proteins as part of a self-protective mechanism of the retina to minimize photoreceptor damage after the mechanical injury induced by retinal detachment is, at present, not known.
La Heij
Ellen C
EC
Department of Ophthalmology, University Hospital Maastricht, The Netherlands.
van de Waarenburg
Marjo P H
MP
Blaauwgeers
Harriet G T
HG
Kessels
Alfons G H
AG
Liem
Albert T A
AT
Theunissen
Charlotte
C
Steinbusch
Harry
H
Hendrikse
Fred
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000378:metabolism; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D014821:Vitrectomy; D018630:Vitreoretinopathy, Proliferative / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D014822:Vitreous Body / Q000378:metabolism*
D005136:Eye Proteins; D015850:Interleukin-6; D016222:Fibroblast Growth Factor 2; D005974:Glutamate-Ammonia Ligase