Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients.
We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).
Pruneri
Giancarlo
G
Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan, School of Medicine, Italy. giancarlo.pruneri@ieo.it
Ponzoni
Maurilio
M
Ferreri
Andrés J M
AJ
Decarli
Nicola
N
Tresoldi
Moreno
M
Raggi
Francesca
F
Baldessari
Chiara
C
Freschi
Massimo
M
Baldini
Luca
L
Goldaniga
Maria
M
Neri
Antonino
A
Carboni
Nadia
N
Bertolini
Francesco
F
Viale
Giuseppe
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD; D018952:Antigens, CD34 / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D000071063:Endoglin; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009101:Multiple Myeloma / Q000098:blood supply*; D015999:Multivariate Analysis; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D011956:Receptors, Cell Surface; D015996:Survival Rate; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1