Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types.
Kluyvera ascorbata produces a beta-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, bla(KLUA), were obtained and were found to have minor variations (96 to 100%). Otherwise, bla(KLUA) was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type beta-lactamases. Finally, mobilization of bla(KLUA) on a plasmid was found to be mediated probably by a genetic mobile element like ISEcp1.
Service de Bactériologie, CHU Cochin, Paris, France.
Christel
C
Humeniuk
Guillaume
G
Arlet
Valerie
V
Gautier
Patrick
P
Grimont
Roger
R
Labia
Alain
A
Philippon
D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D005838:Genotype; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
D001618:beta-Lactamases; C471027:beta-lactamase bla(KLUA), Klyvera ascorbata