A blind comparison of four non-invasive twelve-lead electrocardiogram algorithms for predicting susceptibility to ventricular tachycardia.
BACKGROUND
To reduce QT measurement error, a new method was tested in which high-gain, high-speed, simultaneous 12-lead electrocardiographic (ECG) recordings were obtained during a single cardiac cycle. To increase its predictive power, the utility of combining QTD with the QRS duration for predicting susceptibility to ventricular tachyarrhythmia (VT) was analyzed.


RESULTS
A total of 113 patients referred for electrophysiological study underwent baseline simultaneous 12-lead ECG followed by electrophysiological study to determine VT inducibility. Twenty-six patients had inducible VT while 87 patients did not. QT intervals and the width of QRS complex were measured from a single cardiac cycle with high-gain (8 times normal) and high-speed (100 mm/second) 12-lead ECG recordings. This method resulted in 100% QT interval identification throughout all 12 leads for every patient. Receiver-operator characteristic curves (ROC) and the areas under the ROC curves (AUC) were used to quantitatively analyze the performance of four ECG variables (QTD3, QTD12, QTD12 + QRS and QTD3 + QRS). All four ECG variables were significantly increased in the patients with inducible VT as compared to those without inducible VT. The QTD3 algorithm was less useful than QTD12 in predicting inducible VT; however, the addition of QRS duration to all QTD algorithms enhanced VT detection.


CONCLUSIONS
1) QRS duration has an incremental benefit in the detection of VT when combined with QTD; 2) QTD12 + QRS duration provided the highest predictive power among the four tested algorithms; 3) high-gain, high-speed 12-lead ECG recordings reduced QT measurement error.
Department of Medicine, Winthrop-University Hospital, Mineola, New York, USA.
Todd J
TJ
Cohen
Cindy
C
Quan
Bassiema
B
Ibrahim
Sincha
S
Pollack
Weilun
W
Quan
D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D019540:Area Under Curve; D004198:Disease Susceptibility; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012737:Sex Factors; D017180:Tachycardia, Ventricular / Q000175:diagnosis*