Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants.
4-Hydroxyphenylacetic acid amides and 4-hydroxycinnamamides were synthesized and their antioxidant and neuroprotective activities were evaluated. Among the prepared compounds, 8b, and exhibited potent inhibition of lipid peroxidation in rat brain homogenates, and marked DPPH radical scavenging activities. Furthermore, and exhibited neuroprotective action against the oxidative damage induced by the exposure of primary cultured rat cortical cells to H(2)O(2), xanthine/xanthine oxidase, or Fe(2+)/ascorbic acid. Based on these results, we found that was the most potent antioxidant among the compounds tested.
Medicinal Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-606, Republic of Korea.
Young-Sik
YS
Jung
Tae-Souk
TS
Kang
Joong-Ho
JH
Yoon
Bo-Young
BY
Joe
Hee-Jong
HJ
Lim
Churl-Min
CM
Seong
Woo-Kyu
WK
Park
Jae-Yang
JY
Kong
Jungsook
J
Cho
No-Sang
NS
Park
D000577:Amides / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011422:Propionates; D051381:Rats
D000577:Amides; D000975:Antioxidants; D003373:Coumaric Acids; D010648:Phenylacetates; D011422:Propionates; C008070:4-hydroxyphenylacetic acid; C495469:p-coumaric acid