[Activity of nitric oxide synthase, poly-(ADP-ribose)-polymerase, protein kinase C, protein kinase ASK 1 and internucleosome fragmentation of DNA in HER-2 cells during molybdenum-induction of xanthine oxidase].
It was established that Mo-dependent induction of xanthine oxidase activity caused the decrease of NO aerobic oxidation products as well as S-nitrosothiols concentrations in the HEP-2 cells. The ASK 1 activity in these cells strongly increased and respectively poly-(ADP-ribose)-polymerase as well as protein kinase C activities evidently decreased. The internucleosomal DNA fragmentation in the Mo treated cells increased.
Sumbaev
V V
VV
Mechnikov Odessa National University. sumbayev@rambler.ru
Karpova
O V
OV
Studinskaia
T B
TB
D002460:Cell Line; D053938:DNA Fragmentation; D048848:MAP Kinase Kinase Kinase 5; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism*; D008982:Molybdenum / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000096:biosynthesis*
D009707:Nucleosomes; D008982:Molybdenum; D019001:Nitric Oxide Synthase; D014969:Xanthine Oxidase; D011065:Poly(ADP-ribose) Polymerases; D011493:Protein Kinase C; D048848:MAP Kinase Kinase Kinase 5; D020930:MAP Kinase Kinase Kinases