Intramembrane proteolysis controls diverse signalling pathways throughout evolution.
Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.
Urban
Sinisa
S
MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK. sin@mrc-lmb.cam.ac.uk
Freeman
Matthew
M
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002450:Cell Communication; D002467:Cell Nucleus / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism; D003593:Cytoplasm / Q000502:physiology; D010450:Endopeptidases / Q000378:metabolism*; D019143:Evolution, Molecular; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D009097:Multienzyme Complexes; D014157:Transcription Factors; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex