Reduced grey and white matter volumes in the temporal lobe of male patients with chronic schizophrenia.
Magnetic resonance imaging (MRI) and tissue segmentation were used to quantify grey matter, white matter and cerebrospinal fluid (CSF) volumes in the brains of 32 males with chronic schizophrenia and 32 healthy males. Tissue volumes in the frontal, temporal, parietal, and occipital regions were measured separately. Males with schizophrenia had significant reductions of grey and white matter volumes in the temporal regions compared with controls. Patients also had significantly smaller white matter volumes in the cerebrum and increased CSF volumes in the frontal and the temporal regions as well as the cerebrum. The findings of the present study suggest that volumes of grey and white matter are reduced in the temporal region of males with chronic schizophrenia. The volume of white matter in the whole brain also appears to be reduced. Among the different brains regions, grey matter reduction was significant only in the temporal region.
Department of Clinical Neuroscience, Human Brain Informatics (HUBIN), Psychiatry Section, Karolinska Institute and Hospital, 17176 Stockholm, Sweden. okugawa@takii.kmu.ac.jp
Gaku
G
Okugawa
Göran C
GC
Sedvall
Ingrid
I
Agartz
D000328:Adult; D000704:Analysis of Variance; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D010054:Brief Psychiatric Rating Scale; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012680:Sensitivity and Specificity; D013702:Temporal Lobe / Q000473:pathology*