Unusual cytomegalovirus complications after autologous stem cell transplantation for large B cell lymphoma: massive gastrointestinal hemorrhage followed by a communicating hydrocephalus.
Unusual cytomegalovirus (CMV)-related complications were seen after autologous stem cell transplantation (SCT) in a 50-year-old patient with diffuse large B cell lymphoma. One month after SCT, the patient developed life-threatening upper gastrointestinal tract (GIT) bleeding with several episodes of hemorrhagic shock. Endoscopy and subsequent explorative laparotomy revealed deep-seated bleeding ulcers containing intracellular CMV inclusion bodies distributed extensively in the GIT, from the lower esophagus to the small bowel. Later, she developed gradual loss of consciousness with communicating hydrocephalus which was possibly secondary to CMV-induced ventriculitis. She recovered completely after insertion of a ventriculostomy and subsequent V-P shunt.
Department of Hematology Hadassah University Hospital, Jerusalem, Israel 91120.
Y
Y
Cohen
O
O
Paltiel
G
G
Amir
N
N
Da'as
D
D
Engelhard
A
A
Polliack
D002552:Cerebral Ventricles; D003586:Cytomegalovirus Infections / Q000209:etiology*; D004660:Encephalitis / Q000209:etiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000601:surgery; D016393:Lymphoma, B-Cell / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000628:therapy; D008875:Middle Aged; D014182:Transplantation, Autologous; D017287:Ventriculoperitoneal Shunt