[Prognostic value of gene expression profiling using cDNA arrays in lymphomas].
Lymphomas are the most frequent haematological malignancies in France. Their histoclinical heterogeneity reflects their complex and combinatorial nature which remains poorly elucidated at the molecular level. Today, DNA arrays allow to tackle this diversity by measuring the mRNA expression level of thousands of genes simultaneously in one sample. Recent publications show the potential of DNA arrays to improve the prognostic classification of diffuse large B cell lymphomas and of Hodgkin's lymphoma, by identifying new tumour classes unrecognised by classical factors.
Bertucci
François
F
Département d'oncologie médicale, Institut Paoli-Calmettes, IFR57, 232, boulevard de Sainte-Marguerite, 13273 Marseille, France. bertuccif@marseille.fnclcc.fr
Salas
Sébastien
S
Nasser
Valéry
V
Houlgatte
Rémi
R
Birnbaum
Daniel
D
Xerri
Luc
L
D020869:Gene Expression Profiling; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis