A simple and advantageous protocol for the oxidation of alcohols with O-iodoxybenzoic acid (IBX).
[reaction: see text] An efficient, user-friendly procedure for the oxidation of alcohols using IBX is described. Simply heating a solution of the alcohol in the presence of suspended IBX followed by filtration and removal of the solvent gives excellent yields of the corresponding carbonyl compounds. We illustrate this procedure with a panel of primary and secondary alcohol substrates and note that it allows recycling and reuse of the oxidant.
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Jesse D
JD
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
Finney
Nathaniel S
NS
D000438:Alcohols / Q000737:chemistry; D004787:Environmental Pollution / Q000517:prevention & control; D017743:Equipment Reuse; D007462:Iodobenzenes; D007463:Iodobenzoates / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis*; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D012997:Solvents
D000438:Alcohols; D007462:Iodobenzenes; D007463:Iodobenzoates; D007659:Ketones; D016877:Oxidants; D012997:Solvents; C476101:o-iodoxybenzoic acid