Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: new selective ligands of the 5-HT(7) receptor.
The synthesis and the affinity for the 5-HT(7) receptor and other receptors of a novel series of fused-ring tetrahydropyridine derivatives are described. Some of the compounds showed high affinity for the 5-HT(7) receptor. Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles and are potent ligands for the 5-HT(7) receptor, with high selectivity over the 5-HT(2) receptor and other receptors. These compounds should be useful tools for clarifying the biological role of the 5-HT(7) receptor.
Kikuchi
Chika
C
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760Morooka-cho, Kohoku-ku, 222-8567, Yokohama, Japan. chika_kikuchi@meiji.co.jp
Hiranuma
Toyokazu
T
Koyama
Masao
M
D006801:Humans; D007211:Indoles / Q000378:metabolism*; D008024:Ligands; D011985:Receptors, Serotonin / Q000378:metabolism*
D007211:Indoles; D008024:Ligands; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor