Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.
Studies have shown that bone marrow cells have the potential to differentiate into a variety of cell types. Here we show that bone marrow cells can repopulate the epithelia of the human gastrointestinal tract. Epithelial cells of male donor origin were distributed in every part of the gastrointestinal tract of female bone marrow transplant recipients. Donor-derived epithelial cells substantially repopulated the gastrointestinal tract during epithelial regeneration after graft-versus-host disease or ulcer formation. Regeneration of gastrointestinal epithelia with donor-derived cells in humans shows a potential clinical application of bone marrow-derived cells for repairing severely damaged epithelia, not only in the gastrointestinal tract but also in other tissues.
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan.
Ryuichi
R
Okamoto
Tomoharu
T
Yajima
Motomi
M
Yamazaki
Takanori
T
Kanai
Makio
M
Mukai
Shinichiro
S
Okamoto
Yasuo
Y
Ikeda
Toshifumi
T
Hibi
Johji
J
Inazawa
Mamoru
M
Watanabe
D000328:Adult; D001706:Biopsy; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D004064:Digestive System / Q000166:cytology* / Q000473:pathology; D004068:Digestive System Physiological Phenomena; D004848:Epithelium / Q000473:pathology / Q000502:physiology; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D012038:Regeneration; D014019:Tissue Donors; D014998:Y Chromosome