Transferrin-mediated iron acquisition by pathogenic Neisseria.
The pathogenic Neisseria have a siderophore-independent iron-uptake system reliant on a direct interaction between the bacterial cell and transferrin. In the meningococcus this uptake system is dependent on two surface-exposed transferrin-binding proteins. This short account will review our current knowledge of the transferrin-mediated iron-acquisition system of pathogenic Neisseria.
Evans
R W
RW
Metalloprotein Research Group, The Randall Centre for Molecular Mechanisms of Cell Function, King's College London, 3.6A New Hunt's House, Guy's Campus, London SE1 1UL, UK. robert.evans@kcl.ac.uk
Oakhill
J S
JS
D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D007501:Iron / Q000378:metabolism*; D009345:Neisseria meningitidis / Q000378:metabolism* / Q000472:pathogenicity; D011990:Receptors, Transferrin / Q000737:chemistry / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*; D033863:Transferrin-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D014774:Virulence
D011990:Receptors, Transferrin; D014168:Transferrin; D033863:Transferrin-Binding Proteins; D007501:Iron