NSAIDs in dermatologic therapy: review and preview.
BACKGROUND
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been an important therapy in the treatment of a large number of cutaneous pathologies for more than three decades.


OBJECTIVE
In this retrospective review, we document the use of NSAIDs in more than 15 common and uncommon dermatoses, including acne, psoriasis, sunburn, erythema nodosum, cryoglobulinemia, Sweet's syndrome, systemic mastocytosis, as well as urticarial, livedoid, and nodular vasculitis. NSAIDs act mainly by inhibiting prostaglandin synthesis by the cyclooxygenase (COX) pathway.


CONCLUSIONS
Recent studies link prostaglandin to cutaneous carcinogenesis, thus expanding the dermatologic use of NSAIDs. They may be effective in the treatment and prevention of non-melanoma skin cancer, and specific COX-2 inhibitors promise safer, broader, long-term use of these pharmacologically innovative drugs.
Department of Dermatology, Columbia-Presbyterian Medical Center, New York, New York, USA.
Edward S
ES
Friedman
Nicole
N
LaNatra
Matthew J
MJ
Stiller
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D003880:Dermatology / Q000379:methods; D006801:Humans; D011453:Prostaglandins / Q000096:biosynthesis / Q000378:metabolism; D012189:Retrospective Studies; D012871:Skin Diseases / Q000188:drug therapy / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins