[A study of Bcl-2 expression in normal endometrium and endometrial carcinoma].
To make an initial inquiry into the correlation of development and prognosis with the expression of Bcl-2 protein in endometrial carcinoma, we detected the Bcl-2 protein expression in 40 normal and 60 malignant samples of the endometrium by means of an immunohistochemical technique. We observed that Bcl-2 expression varied with menstrual cycle, becoming stronger in proliferative phase and then declining in secretory phase. Bcl-2 expression in endometrial carcinoma was much weaker than that in normal endometrium, and Bcl-2 was particularly expressed in adenoacanthoma, papillary adenocarcinoma and simple adenocarcinoma. The higher grade and stage were, the stronger Bcl-2 expression was (P < 0.01). In 5 cases of endometrial carcinoma with hyperplastic endometrium, Bcl-2 expression of carcinoma was obviously weaker than that of hyperplastic endometrium. So we conclude that Bcl-2 overexpression may contribute to the formation of hyperplastic endometrium, that obvious reduction of Bcl-2 expression in endometrial carcinoma may promote apoptosis of cells, and that Bcl-2 over-expression may be associated with good prognosis.
Department of Obstetrics and Gynecology, Second Affiliated Hospital, WCUMS, Chengdu 610041.
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Peng
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D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D017209:Apoptosis; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics
D019253:Proto-Oncogene Proteins c-bcl-2