The synthesis of some triazolylphenothiazine derivatives and their antidepressant and anxiolytic activities.
10-[2-(4-Amino-5-mercapto-1,2,4-triazol-3-yl)ethyl]phenothiazine was prepared starting from 3-(10-phenothiaziniyl)propionic acid. This new triazole was employed in the synthesis of some Schiff bases and N-bridged heterocycles. All the newly synthesized compounds were characterized by analytical, IR, 1H-NMR and MASS Spectral studies. Some of the newly synthesized compounds were screened for their antidepressant and anxiolytic activities.
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskişehir, Turkey.
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Turan-Zitouni
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Kaplancikli
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Kiliç
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Erol
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013550:Swimming / Q000523:psychology; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D007202:Indicators and Reagents; D013843:Thiazines; C465485:triazolylphenothiazine