A prospective comparative study on IVF outcomes with either purified FSH or human menopausal gonadotrophin in downregulated normogonadotrophic women.
OBJECTIVE
In compare the use of purified follicle-stimulating hormone with that of a preparation containing follicle-stimulating hormone and luteinizing hormone in infertile females undergoing IVF.


METHODS
Open-labelled prospective controlled single-center study.


METHODS
Nile Badrawy IVF unit.


METHODS
153 infertile females undergoing their first cycle of IVF divided into 2 groups.


METHODS
Ovarian stimulation was done with either highly purified FSH for group 1 (n = 75) or human menopausal gonadotrophin group 2 (n = 78) after pituitary desensitization commenced in the midluteal phase of the preceding cycle. Monitoring was performed by ultrasound transvaginal oocyte retrieval followed by IVF and transfer of three embryos.


RESULTS
Number of oocytes >18 mm at day of hCG, fertilization rate, embryo transfer rate, clinical pregnancy rate and incidence of ovarian hyperstimulation syndrome.


RESULTS
The response to ovarian hyperstimulation was similar in both groups. The number of follicles >18 mm achieved at day of hCG was 12.3 +/- 0.9 (mean +/- SEM) following stimulation with 38.3 +/- 0.9 ampoules of Fostimon The Menogon-treated group needed 39.1 +/- 0.8 ampoules to produce 11.6 +/- 0.7 follicles. Fertilization rate (2PN/cell) was 58.6 vs. 64.2% in the Fostimon and Menogon group, respectively (p > 0.05). The number of embryos transferred per woman was 3.1 +/- 0.1 in the Fostimon group and 3.6 +/- 0.1 in the Menogon group. The pregnancy rate per woman was 33.3 vs. 25.6% in the Fostimon- and Menogon-treated groups, respectively (p > 0.05). Miscarriage rate was 16 vs 20%, respectively. However, the incidence of multiple pregnancies was significantly higher in the Fostimon-treated group (32%) vs. 10% only in the Menogon-treated group (p < 0.01).


CONCLUSIONS
Purified FSH yields similar clinical outcome to hMG in terms of oocytes retrieved and clinical pregnancies in a standard IVF regimen.
Cairo University, Cairo, Egypt.
Aboul Foutouh
AF
Ismail
Al-Inany
AI
Hesham
Zaki
Z
Salah
M
M
Khaled
Nahas
N
Fouad
Nasr
N
Ashraf
Shawky
S
Hatem
Badrawi
B
Hamdi
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000628:therapy*; D007273:Injections, Intramuscular; D008596:Menotropins / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy / Q000706:statistics & numerical data*; D011336:Probability; D011446:Prospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome
D008596:Menotropins; D005640:Follicle Stimulating Hormone