Reproductive toxicity of gamma-ethyl-gamma-phenyl-butyrolactone, a new anticonvulsant and hypnotic drug, in mice. Fertility and peri- and post-natal studies.
The reproductive toxicity of gamma-ethyl-gamma-phenyl-butyrolactone (EPBL, CAS 53380-21-5), a new anticonvulsant and hypnotic drug, was investigated by performing fertility and peri- and post-natal studies in mice. In both studies, EPBL was administered by gavage at 0, 50, 10, or 200 mg/kg doses. The first study found parent toxicity as measured by reduced body weight at the higher dose. At the same dose, the number of live fetuses was decreased. However, neither male or female fertility nor the reproductive performance of mice were affected. The results of the second study showed that the only negative effects were a depression of maternal weight gain and a decrease in body weight of the litter at birth which was 200 mg/kg. A reduction in the survival rate was also seen. There was no evidence that treatment of F0 females from day 15 of pregnancy to day 21 post-partum affected either the reproductive capacity of the F1 offspring or the development of F2 progenies. The non observed effects levels (NOEL) for both studies can be estimated at 100 mg/kg.
Department of Toxicology, National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico. gchamcev@hotmail.com
Germán
G
Chamorro
Fernando
F
Vega
Eduardo
E
Madrigal
María
M
Salazar
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000633:toxicity*; D001724:Birth Weight / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000633:toxicity*; D008297:Male; D051379:Mice; D019055:No-Observed-Adverse-Effect Level; D011247:Pregnancy; D013723:Teratogens / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D013723:Teratogens; C465476:gamma-ethyl-gamma-phenyl-butyrolactone; D015107:4-Butyrolactone