Total synthesis of proposed amphidinolide A via a highly selective ring-closing metathesis.
[structure: see text] A highly convergent synthesis of the proposed structure of amphidinolide A is reported. Instructive applications of several organometallic processes are illustrated, including a highly selective ring-closing metathesis reaction.
Maleczka
Robert E
RE
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA. maleczka@cem.msu.edu
Terrell
Lamont R
LR
Geng
Feng
F
Ward
Joseph S
JS
D000970:Antineoplastic Agents / Q000138:chemical synthesis; D003500:Cyclization; D004809:Ephedrine / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D008387:Marine Toxins / Q000138:chemical synthesis*; D000097442:Amphidinolides
D000970:Antineoplastic Agents; D004809:Ephedrine; D007783:Lactones; D018942:Macrolides; D008387:Marine Toxins; C469329:amphidinolide A; D000097442:Amphidinolides