RNA silencing: small RNAs as ubiquitous regulators of gene expression.
'RNA silencing' is the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by RNA. Initially identified as an immune system that is targeted against transposons and viruses, RNA silencing is emerging as a fundamental regulatory process that is likely to affect many layers of endogenous gene expression in most, if not all, eukaryotes.
Voinnet
Olivier
O
The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK. Olivier.voinnet@ibmp-ulp.u-strasbg.fr
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D020868:Gene Silencing; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity; D014158:Transcription, Genetic / Q000235:genetics*
D035683:MicroRNAs; D034741:RNA, Small Interfering