Increased urine phenylethylamine after methylphenidate treatment in children with ADHD.
The urine levels of beta-phenylethylamine, 3-methoxy-4-hydroxyphenyl glycol, homovanillic acid, and 5-hydroxyindoleacetic acid were measured to clarify the neurochemical mechanism in attention deficit hyperactivity disorder. beta-Phenylethylamine levels were significantly lower in attention deficit hyperactivity disorder individuals (n = 37) than in controls (n = 21). The 22 children with attention deficit hyperactivity disorder were treated with methylphenidate, and they were further divided into methylphenidate responders (n = 18) and nonresponders (n = 4). beta-Phenylethylamine levels significantly increased after methylphenidate therapy in responders, whereas they did not increase in nonresponders.
Kusaga
Akira
A
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Japan.
Yamashita
Yushiro
Y
Koeda
Tastuya
T
Hiratani
Michio
M
Kaneko
Mika
M
Yamada
Shigeto
S
Matsuishi
Toyojiro
T
D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy* / Q000652:urine*; D001321:Autistic Disorder / Q000652:urine; D015415:Biomarkers; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008774:Methylphenidate / Q000627:therapeutic use*; D010627:Phenethylamines / Q000652:urine*; D011237:Predictive Value of Tests
D015415:Biomarkers; D000697:Central Nervous System Stimulants; D010627:Phenethylamines; D008774:Methylphenidate