Quantitative structure-retention relationships of xanthines in RP HPLC systems with the new Chromolith RP-18e stationary phases.
The structural descriptors with the best potential for predicting the reversed-phase retention of xanthines and their derivatives on the new Chromolith RP-18e columns have been examined, as has the molecular mechanism of the separation. QSRR analysis was performed by simultaneous solution of a set of linear equations. The logarithms of the capacity factors were the dependent variables. Structural descriptors calculated by means of semi-empirical methods of quantum chemistry were chosen as independent variables.
Department of Analytical and General Chemistry, Silesian Technical University, ul. Strzody 7, 44-100 Gliwice, Poland. baranows@polsl.gliwice.pl
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