Increased expression of mRNAs for microtubule disassembly molecules during nerve regeneration.
The mRNA expression of the microtubule disassembly molecules (SCG10, stathmin, SCLIP and RB3) in response to nerve injury was examined using a rat hypoglossal nerve injury model. After nerve injury prominent increase in mRNA expression of SCG10, stathmin and RB3 was observed, while only slight increase in SCLIP mRNA was observed in injured motor neurons. The increase in SCG10 and RB3 mRNA expression was quicker than that of stathmin and SCLIP. All the elevated signals decreased gradually to control levels by 4 weeks after nerve injury.
Department of Anatomy, Asahikawa Medical College, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Japan.
Tatsuya
T
Iwata
Kazuhiko
K
Namikawa
Masaru
M
Honma
Nozomu
N
Mori
Sunao
S
Yachiku
Hiroshi
H
Kiyama
D000818:Animals; D002352:Carrier Proteins; D020209:Cranial Nerve Injuries / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D020439:Growth Cones / Q000378:metabolism / Q000648:ultrastructure; D007002:Hypoglossal Nerve / Q000254:growth & development* / Q000378:metabolism; D061228:Hypoglossal Nerve Injuries; D008297:Male; D008565:Membrane Proteins; D008868:Microtubule Proteins; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D008870:Microtubules / Q000235:genetics / Q000378:metabolism; D009414:Nerve Growth Factors / Q000235:genetics; D009416:Nerve Regeneration / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D050777:Stathmin; D013997:Time Factors; D015854:Up-Regulation / Q000235:genetics*
D002352:Carrier Proteins; D008565:Membrane Proteins; D008868:Microtubule Proteins; D008869:Microtubule-Associated Proteins; D009414:Nerve Growth Factors; D010750:Phosphoproteins; D012333:RNA, Messenger; D050777:Stathmin; C512848:Stmn2 protein, rat; C491792:Stmn3 protein, rat; C112286:Stmn4 protein, rat