Contribution of Candida albicans ALS1 to the pathogenesis of experimental oropharyngeal candidiasis.
We investigated the contribution of Candida albicans ALS1, which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection.
Biological Research Laboratory, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan. ykamai@shina.sankyo.co.jp
Yasuki
Y
Kamai
Mikie
M
Kubota
Yoko
Y
Kamai
Tsunemichi
T
Hosokawa
Takashi
T
Fukuoka
Scott G
SG
Filler
D000818:Animals; D002176:Candida albicans / Q000235:genetics* / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D002448:Cell Adhesion / Q000235:genetics / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics* / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D009154:Mutation; D014059:Tongue / Q000382:microbiology; D014774:Virulence / Q000235:genetics / Q000502:physiology
C093538:ALS1 protein, Candida albicans; D005656:Fungal Proteins