Identification and localization of glycine in the inner core lipopolysaccharide of Neisseria meningitidis.
The amino acid glycine is identified as a component of the inner core oligosaccharide in meningococcal lipopolysaccharide (LPS). Ester-linked glycine residues were consistently found by mass spectrometry experiments to be located on the distal heptose residue (HepII) in LPS from several strains of Neisseria meningitidis. Nuclear magnetic resonance studies confirmed and extended this observation locating the glycine residue at the 7-position of the HepII molecule in L3 and L4 immunotype strains.
Institute for Biological Sciences, National Research Council, Ottawa, Ontario K1A 0R6, Canada. Andrew.Cox@nrc.ca
Andrew D
AD
Cox
Jianjun
J
Li
James C
JC
Richards
D005998:Glycine / Q000032:analysis* / Q000737:chemistry; D008070:Lipopolysaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009345:Neisseria meningitidis / Q000737:chemistry*; D010446:Peptide Fragments / Q000378:metabolism
D008070:Lipopolysaccharides; D010446:Peptide Fragments; D005998:Glycine