Hemothorax and retroperitoneal hematoma after anticoagulation with enoxaparin.
A 58-year-old woman with chronic obstructive pulmonary disease had spontaneous bilateral hemothorax and a retroperitoneal hematoma after 4 days of anticoagulation therapy with enoxaparin (1 mg/kg subcutaneously every 12 hours) for suspected pulmonary thromboembolism. The patient was successfully managed with red blood cell and plasma transfusions, multiple thoracenteses for evacuation of blood from the pleural space, short-term mechanical ventilation, and administration of bronchodilators, corticosteroids, and antibiotics. This is the first report of spontaneous hemothorax and the third report of spontaneous retroperitoneal hematoma associated with enoxaparin therapy.
Mrug
Michal
M
Department of Internal Medicine, University of South Alabama College of Medicine, Mobile, USA.
Mishra
Prashant V
PV
Lusane
Henry C
HC
Cunningham
J Martin
JM
Alpert
Martin A
MA
D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D017984:Enoxaparin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006406:Hematoma / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D006491:Hemothorax / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000188:drug therapy; D011859:Radiography; D012187:Retroperitoneal Space / Q000000981:diagnostic imaging / Q000473:pathology
D000925:Anticoagulants; D017984:Enoxaparin