Developmental regulation of somite derivatives: muscle, cartilage and tendon.
Recent research has broadened significantly our understanding of how the somite, a specialized mesodermal structure found in vertebrate embryos, gives rise to the cartilage, muscle and tendon cell lineages. The specification of somite derivatives involves the action of patterning signals secreted from adjacent tissue combined with the activation, in particular somitic compartments, of genes promoting cell lineage specification.
Brent
Ava E
AE
Harvard Medical School, Department of Genetics, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
Tabin
Clifford J
CJ
D000818:Animals; D019521:Body Patterning; D002356:Cartilage / Q000196:embryology*; D002454:Cell Differentiation; D002642:Chick Embryo; D004268:DNA-Binding Proteins; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000166:cytology; D018482:Muscle, Skeletal / Q000196:embryology*; D015398:Signal Transduction / Q000502:physiology; D019170:Somites / Q000166:cytology* / Q000378:metabolism; D013710:Tendons / Q000196:embryology*; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D014157:Transcription Factors