Technology and physico-chemical evaluation of solid ocular inserts containing sulfadicramide and hyaluronic acid.
Synthetic lipophilic membranes, containing sulfadicramide (SDC), disodium salt of hyaluronic acid and disodium salt of taurolithocholic acid were prepared as described (Fürst et al.). Rate constants of SDC release from the above membranes and its apparent permeability coefficients through the comea isolated from the pig's eyes were determined.
Department of Physical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
E
E
Grześkowiak
D
D
Partyka
M
M
Simon
M
M
Zgrabczyńska
A
A
Wiśniewska
D000577:Amides / Q000493:pharmacokinetics*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003315:Cornea / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006820:Hyaluronic Acid / Q000493:pharmacokinetics*; D008567:Membranes, Artificial; D013552:Swine
D000577:Amides; D008567:Membranes, Artificial; C116461:sulphadicramide; D006820:Hyaluronic Acid