Determinants of plasminogen activator inhibitor-1 in South Asians with ischaemic stroke.
To investigate the relationship of circulating plasminogen activator inhibitor-1 (PAI-1) levels with features of insulin resistance and genotype at a single nucleotide insertion/deletion (4G/5G) polymorphism in the promoter region of the PAI-1 gene in 101 South Asian ischaemic stroke patients and 102 symptom-free reference subjects. The allele frequencies were 4G-0.51, 5G-0.49 and 4G-0.61, 5G-0.39 in patients and reference subjects, respectively. There was a significant association between PAI-1 promoter genotype and PAI-1 antigen levels in patients. Regression analysis with significant correlates in the model demonstrated age, gender and triglycerides in patients and fasting insulin and HDL cholesterol in reference subjects as independent predictors of PAI-1 antigen.
Academic Unit of Molecular Vascular Medicine (University of Leeds), Leeds General Infirmary, Leeds, UK. k.kain@leeds.ac.uk
Kirti
K
Kain
John
J
Young
John
J
Bamford
John
J
Bavington
Peter J
PJ
Grant
Andrew J
AJ
Catto
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001211:Asia, Western / Q000453:epidemiology; D001824:Body Constitution; D015992:Body Mass Index; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics / Q000378:metabolism; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics; D011237:Predictive Value of Tests; D011401:Promoter Regions, Genetic / Q000235:genetics; D017384:Sequence Deletion / Q000235:genetics; D012737:Sex Factors; D013223:Statistics as Topic; D020521:Stroke / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides