Mixed periodontal Th1-Th2 cytokine profile in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)- mediated alveolar bone destruction in vivo.
The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo.
Division of Periodontics and Department of Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Canada. yateng@uwo.ca
Yen-Tung A
YT
Teng
D000189:Actinobacillus Infections / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D016976:Aggregatibacter actinomycetemcomitans / Q000472:pathogenicity*; D016301:Alveolar Bone Loss / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002678:Chimera; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D017708:Leukocyte Transfusion; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D010518:Periodontitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D002352:Carrier Proteins; D016207:Cytokines; D008562:Membrane Glycoproteins; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human; C505687:Tnfrsf11a protein, mouse; C505689:Tnfsf11 protein, mouse