Ligand-free palladium catalysis of the Suzuki reaction in water using microwave heating.
[reaction: see text] We report the ligand-free palladium catalysis of the Suzuki reaction in water using microwave heating. Our methodology uses low palladium loadings (0.4 mol %), is fast (5-10 min reaction time), and is useful for couplings involving boronic acids and aryl iodides, bromides, and chlorides.
Department of Chemistry, King's College London, Strand, London WC2R 2LS, UK. nicholas.leadbeater@kcl.ac.uk
Nicholas E
NE
Leadbeater
Maria
M
Marco
D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D004787:Environmental Pollution / Q000517:prevention & control; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D008872:Microwaves; D010165:Palladium / Q000737:chemistry; D014867:Water
D001897:Boronic Acids; D006841:Hydrocarbons, Aromatic; D006846:Hydrocarbons, Halogenated; D014867:Water; D010165:Palladium