Predictors of response to treatment for chronic fatigue syndrome.
BACKGROUND
Controlled trials have shown that psychological interventions designed to encourage graded exercise can facilitate recovery from chronic fatigue syndrome.


OBJECTIVE
To identify predictors of response to psychological treatment for chronic fatigue syndrome.


METHODS
Of 114 patients assigned to equally effective treatment conditions in a randomised, controlled trial, 95 completed follow-up assessments. Relationships between variables measured prior to randomisation and changes in physical functioning and subjective handicap at 1 year were evaluated by multiple regression.


RESULTS
Poor outcome was predicted by membership of a self-help group, being in receipt of sickness benefit at the start of treatment, and dysphoria as measured by the Hospital Anxiety and Depression scale. Severity of symptoms and duration of illness were not predictors of response.


CONCLUSIONS
Poor outcome in the psychological treatment of chronic fatigue syndrome is predicted by variables that indicate resistance to accepting the therapeutic rationale, poor motivation to treatment adherence or secondary gains from illness.
Department of Psychology, University of Manchester, Coupland I Building, Oxford Road, Manchester M13 9PL, UK.
Richard P
RP
Bentall
Pauline
P
Powell
Fred J
FJ
Nye
Richard H T
RH
Edwards
D000041:Absenteeism; D000928:Antidepressive Agents / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000523:psychology; D003866:Depressive Disorder / Q000523:psychology; D015673:Fatigue Syndrome, Chronic / Q000523:psychology / Q000628:therapy*; D006801:Humans; D008132:Loneliness; D010349:Patient Compliance / Q000523:psychology; D011613:Psychotherapy / Q000379:methods; D012657:Self-Help Groups; D016896:Treatment Outcome
D000928:Antidepressive Agents