Massive triiodothyronine intoxication: efficacy of hemoperfusion?
A case of massive accidental triiodothyronine intoxication (1000-fold the usual therapeutic dose, for 8 days) is reported with important disturbances of cardiovascular and central nervous systems that required intensive care support. Serum free triiodothyronine levels were 4789 pmol L(-1) on admittance (normal values, 3.5-6.5 pmol x L(-1)). In the absence of a specific treatment, hemoperfusions were performed but failed to accelerate significantly the decay of blood levels of free triiodothyronine (apparent half-life 25.9 hours; 95% confidence interval: 19.8-37.4 hours). The patient, a young woman, made a satisfactory recovery, in spite of important clinical complications.
Endocrinology Department, University Hospital Dr. Peset, University of Valencia, Valencia, Spain.
Eva
E
Solá
Marcelino
M
Gómez-Balaguer
Carlos
C
Morillas
Sandra
S
Garzón
Santiago
S
García
Esteban J
EJ
Morcillo
Antonio
A
Hernández-Mijares
D000328:Adult; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000628:therapy; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000628:therapy; D003422:Critical Care; D005260:Female; D006464:Hemoperfusion / Q000592:standards*; D006801:Humans; D011041:Poisoning / Q000628:therapy; D014284:Triiodothyronine / Q000506:poisoning*
D014284:Triiodothyronine