[Immunosuppressive components of extracellular lipopolysaccharide highly virulent strain Salmonella typhimurium 1468].
Immunosuppressive activity of culture liquid substrate (CFS) of highly virulent strain Salmonella typhimurium has been studied. A model of delayed hypersensitivity (DHS) to nonbacterial antigen in mice, a method of gel-filtration through the sephadex column G-200, immunosorbents were used. Three components with immunosuppressive activity: thermolabile component and thermostable one with direct immunosuppressive action and the third thermolabile component which manifested inductive immunosuppressive activity only after redox treatment have been revealed in the strain CFS. O-specific and lipid parts were found in the composition of all the components. This allowed them to be related to lipopolysaccharide.
Taras Shevchenko Kyiv National University.
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Molozhavaia
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Borisova
D000818:Animals; D003470:Culture Media / Q000737:chemistry; D004195:Disease Models, Animal; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007164:Immunosorbents; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D019081:O Antigens / Q000302:isolation & purification / Q000494:pharmacology; D010084:Oxidation-Reduction; D012486:Salmonella typhimurium / Q000276:immunology / Q000472:pathogenicity*; D013696:Temperature; D014774:Virulence
D003470:Culture Media; D007164:Immunosorbents; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D019081:O Antigens