Multisubstrate analogue inhibitors of glucosamine-6-phosphate synthase from Candida albicans.
Compounds 1-6 were designed as multisubstrate inhibitors of glucosamine synthase. These compounds are also useful probes for measuring the distances between the two active sites in the multidomain protein. Our data suggest that the two binding pockets are in close proximity to each other.
Chittur
Sridar
S
Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 26505, Morgantown, WV, USA. schittur@myomatric.com
Griffith
Robert
R
D001665:Binding Sites; D002176:Candida albicans / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)