Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries.
The organisation of the animal body into distinct tissues requires adhesive mechanisms that promote and maintain the physical segregation, the sorting, of different cell populations. Signals that control differential cell affinities across tissue boundaries have been identified, including Hedgehog, Notch, and EGF receptor signalling. Further, several examples demonstrate that cell sorting in vivo can be driven by Eph/ephrin signalling and by the differential expression of cadherins that modulate cell adhesion and motility.
Tepass
Ulrich
U
Department of Zoology, University of Toronto, 25 Harbord Street, Ontario M5S 3G5, Toronto, Canada. utepass@zoo.utoronto.ca
Godt
Dorothea
D
Winklbauer
Rudolf
R
D000818:Animals; D015820:Cadherins; D002448:Cell Adhesion; D002450:Cell Communication; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D002465:Cell Movement; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000254:growth & development* / Q000502:physiology; D036342:Ephrins / Q000502:physiology*; D066246:ErbB Receptors / Q000378:metabolism; D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*
D015820:Cadherins; D029721:Drosophila Proteins; D036342:Ephrins; D053823:Hedgehog Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases