[Ventricular tachycardia and long QT associated with clarithromycin administration in a patient with HIV infection].
Prolongation of the QT interval is associated with a high risk of serious ventricular tachyarrhythmias, usually torsade de pointes (TdP) polymorphic ventricular tachycardia, although monomorphic ventricular tachycardia may also develop. Both congenital and acquired forms have been reported, acquired forms being much more prevalent. An association between human immunodeficiency virus (HIV) infection and a higher rate of dilated cardiomyopathy has also been recognized. The severity of immunodeficiency seems to influence both the incidence and severity of cardiomyopathy. A higher prevalence of QT prolongation has been reported among hospitalized HIV-positive patients with HIV infection, possibly related to drugs prescribed for such patients or to an acquired form of long QT syndrome arising from HIV infection. We report a case of QT prolongation and development of ventricular arrhythmia in one HIV patient that started with intravenous clarithromycin and cotrimoxazole therapy.
Servicios de Cardiología, Hospital General Vall d'Hebron, Barcelona, Spain.
Nuria
N
Vallejo Camazón
Dolors
D
Rodríguez Pardo
Antonio
A
Sánchez Hidalgo
María Pilar
MP
Tornos Mas
Esteban
E
Ribera
Jordi
J
Soler Soler
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D017291:Clarithromycin / Q000009:adverse effects*; D004562:Electrocardiography; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D017180:Tachycardia, Ventricular / Q000139:chemically induced*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D017291:Clarithromycin