A new synthetic route towards the mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside.
Novel synthetic approach to mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside was attained from the coupling of lithiated 2,4-dimethoxy-6-methylpyrimidine with 1-benzyloxy-3-(tert-butyldiphenylsilyloxy)propan-2-one, followed by the sequential reactions of methylthiomethylation, cyclization, hydroxylation, and dealkylation.
Liu
Chi-Tsan
CT
School of Pharmacy, National Defense Medical Center, Neihu, Taipei, Taiwan, ROC.
Tu
Tsu-Chiang
TC
Hsu
Ling-Yih
LY
D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D006839:Hydrocarbons, Acyclic; D009841:Oligonucleotides; D011741:Pyrimidine Nucleosides