A liquid-phase peptide synthesis in cyclohexane-based biphasic thermomorphic systems.
Combinations of typical organic solvents composed of cyclohexane and qualified aprotic polar organic solvents were found to realize an effective, biphasic thermomorphic system in arbitrary ratios of upper and lower phases that enable a practical application of a liquid-phase peptide synthesis.
Chiba
Kazuhiro
K
Laboratory of Bio-Organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan. chiba@cc.tuat.ac.jp
Kono
Yusuke
Y
Kim
Shokaku
S
Nishimoto
Kohsuke
K
Kitano
Yoshikazu
Y
Tada
Masahiro
M
D000596:Amino Acids; D003510:Cyclohexanes / Q000737:chemistry; D005449:Fluorenes; D008722:Methods; D010455:Peptides / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry
D000596:Amino Acids; D003510:Cyclohexanes; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides; D012997:Solvents