Coronary active perfusion system can maintain myocardial blood flow and tissue oxygenation.
OBJECTIVE
To avoid myocardial ischemia in off-pump coronary artery bypass, we developed a coronary active perfusion system (CAPS). The purposes of this study were to investigate the changes in myocardial blood flow and tissue oxygenation during CAPS perfusion, and to validate the ventricular arrhythmias and hemodynamic deterioration preventing the effect.


METHODS
Sixteen pigs were divided into a CAPS perfusion group (group C) and a simple coronary occlusion group (group O). The left anterior descending coronary artery was snared in both groups and 30 min of CAPS perfusion was performed in group C.


RESULTS
Ventricular arrhythmias were not observed in group C, but occurred in seven out of eight pigs in group O (P=0.003). None of the hemodynamic variables changed in group C, but they deteriorated in group O. Myocardial blood flow, saturation, and hemoglobin plus myoglobin concentration were maintained with a baseline level in group C, but decreased significantly in group O (P<0.001).


CONCLUSIONS
CAPS is a reliable method to avoid myocardial ischemia during coronary occlusion and it may be useful for off-pump coronary artery bypass
Department of Surgery (I), Kanazawa University School of Medicine, Takaramachi 13-1, Kanazawa 920-8641, Japan. h.kamiya@trition.ocn.ne.jp
Hiroyuki
H
Kamiya
Go
G
Watanabe
Toshio
T
Doi
Taro
T
Saito
Masao
M
Takahashi
Shigeyuki
S
Tomita
Toshihide
T
Tsukioka
Taro
T
Kanamori
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D001026:Coronary Artery Bypass; D003326:Coronary Circulation; D006439:Hemodynamics; D006454:Hemoglobins / Q000032:analysis; D009206:Myocardium / Q000378:metabolism*; D009211:Myoglobin / Q000032:analysis; D010100:Oxygen / Q000378:metabolism*; D011673:Pulsatile Flow; D013552:Swine
D006454:Hemoglobins; D009211:Myoglobin; D010100:Oxygen