A stable DNA duplex containing a non-hydrogen-bonding and non-shape-complementary base couple: interstrand stacking as the stability determining factor.
The stabilizing effect of a dG:dC base-pair can also be imparted to a DNA duplex by a non-hydrogen-bonding, non-shape-complementary nucleoside analogue when interstrand stacking interactions come into play. This is the case, for example, with dBP, which has a bipyridyl (BP) residue as a nucleobase surrogate (the picture shows a dBP:dBP pair).
Department of Chemistry and Biochemistry, University of Bern Freiestrasse 3, 3012 Bern, Switzerland, Fax: (+41) 31-631-3422.
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Brotschi
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Häberli
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Leumann
DNA recognition; DNA structures; N ligands; nucleobases; oligonucleotides