Oxygen transport across vasa recta in the renal medulla.
In this model of oxygen transport in the renal medullary microcirculation, we predicted that the net amount of oxygen reabsorbed from vasa recta into the interstitium is on the order of 10(-6) mmol/s, i.e., significantly lower than estimated medullary oxygen requirements based on active sodium reabsorption. Our simulations confirmed a number of experimental findings. Low medullary PO(2) results from the countercurrent arrangement of vessels and an elevated vasa recta permeability to oxygen, as well as high metabolic needs. Diffusional shunting of oxygen between descending vasa recta (DVR) and ascending vasa recta also explains why a 20-mmHg decrease in initial PO(2) at the corticomedullary junction only leads to a small drop in papillary tip PO(2) (<2 mmHg with baseline parameter values). Conversely, small changes in the consumption rate of DVR-supplied oxygen, in blood flow rate, in hematocrit, or in capillary permeability to oxygen, beyond certain values sharply reduce interstitial PO(2). Without erythrocytes, papillary tip PO(2) cannot be maintained above 10 mmHg, even when oxygen consumption is zero.
Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts 02155, USA.
Wensheng
W
Zhang
Aurélie
A
Edwards
D000818:Animals; D002199:Capillary Permeability / Q000502:physiology; D006400:Hematocrit; D000860:Hypoxia / Q000378:metabolism; D007679:Kidney Medulla / Q000098:blood supply / Q000378:metabolism*; D008322:Mammals; D008833:Microcirculation / Q000502:physiology; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D012079:Renal Circulation / Q000502:physiology
D010100:Oxygen