[Toxic effects of various water pollutants on structural and functional parameters of hepatocytes].
A prolonged intragastral intoxication of male and female rats by low doses of fluorine, zinc, chromium, arsenite, and combination of these compounds lead to developing cytolysis and hepatic-cellular insufficiency. These changes are more pronounced in female rats especially if chromium, arsenite and a combination of toxicants were used. They lead to developing hyper lipid peroxidation in male rats the most expressed by intoxication with arsenite and combined effect. Unlike to male rats LPO intensity in female rats was more pronounced and fixed by effect of all preparations. SOD activation was revealed to be in male rats by effect of chromium and especially zinc, in female rats by effect of fluorine and zinc. A distinctive inhibition of SOD activity determined to be by using arsenite and combination of toxicants. Activation of catalase especially in male rats was also revealed. Activation of membrane-destructive processes in the liver of experimental animals results in reducing pharmaco-metabolizing function of this organ.
Tashkent State Second Medical Institute, Uzbekistan.
Kh Ia
KhIa
Karimov
F Kh
FKh
Inoiatova
F Sh
FSh
Inoiatov
D000818:Animals; D018053:Arsenites / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D004357:Drug Synergism; D004789:Enzyme Activation; D005260:Female; D022781:Hepatocytes / Q000187:drug effects* / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017680:Potassium Compounds / Q000633:toxicity; D051381:Rats; D012737:Sex Factors; D012969:Sodium Fluoride / Q000633:toxicity; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D019287:Zinc Sulfate / Q000633:toxicity
D018053:Arsenites; D017680:Potassium Compounds; D014874:Water Pollutants, Chemical; D008315:Malondialdehyde; D019287:Zinc Sulfate; D012969:Sodium Fluoride; C032793:arsenous acid; D002374:Catalase; D013482:Superoxide Dismutase