Examination of the temporal relationship between smoking and major depressive disorder among low-income women in public primary care clinics.
OBJECTIVE
To determine the prevalence of major depressive disorder (MDD) by smoking status, and the temporal relationship between smoking and MDD, and explore other smoking-related variables that may be associated with MDD.


METHODS
Cross-sectional study.


METHODS
Public primary care clinics.


METHODS
Researchers studied 338 women (76% African-Americans) who were randomly selected while attending appointments in two public primary care clinics.


METHODS
Data pertaining to smoking-related variables and MDD diagnosis were obtained using the Diagnostic Interview Schedule for the Diagnostic Statistical Manual of Mental Disorder IV (DSM-IV).


RESULTS
The prevalence of a lifetime history of MDD was significantly higher for current smokers (56.6%) than among former smokers (37.5%) or never-smokers (30.3%; p < .001). Most ever-smokers (81.3%) began smoking and were nicotine-dependent (63.6%) prior to their first episode of MDD. Using logistic regression, after controlling for demographic and smoking-related variables, age of smoking onset was the strongest variable associated with MDD among ever-smokers. Specifically, the odds of having an MDD decreased by 8.2% for each year delay in smoking initiation.


CONCLUSIONS
These results suggest that smoking initiation precedes MDD and that smoking is associated with a high prevalence of MDD among low-income women attending primary care clinics. Further, the younger women start smoking the more likely they are to have MDD.
Scarinci
Isabel C
IC
University of Memphis Center for Community Health, Memphis, Tennessee, USA.
Thomas
Janet
J
Brantley
Phillip J
PJ
Jones
Glenn N
GN
D017668:Age of Onset; D000554:Ambulatory Care Facilities; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000150:complications / Q000453:epidemiology* / Q000208:ethnology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008145:Louisiana / Q000453:epidemiology; D008875:Middle Aged; D011203:Poverty; D015995:Prevalence; D011320:Primary Health Care; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology* / Q000208:ethnology; D013997:Time Factors