Tool-use learning induces BDNF expression in a selective portion of monkey anterior parietal cortex.
Learning but not execution of tool-use induced expression of brain-derived neurotrophic factor (BDNF). The expression was highest in the anterior bank of the intraparietal sulcus, especially in the region posteriorly adjacent to the somatosensory shoulder and forearm region in area 3b, suggesting that BDNF plays a role in altering the body image of the hand to include the repeatedly used tool as its extension.
Section of Cognitive Neurobiology, Department of Maxillofacial Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8549, Tokyo, Japan. ishibashi.cnb@tmd.ac.jp
Hidetoshi
H
Ishibashi
Sayaka
S
Hihara
Mariko
M
Takahashi
Toshio
T
Heike
Takashi
T
Yokota
Atsushi
A
Iriki
D000818:Animals; D001931:Brain Mapping; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D006225:Hand / Q000294:innervation / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008251:Macaca; D009048:Motor Skills / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010296:Parietal Lobe / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D013003:Somatosensory Cortex / Q000166:cytology / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D019208:Brain-Derived Neurotrophic Factor; D012333:RNA, Messenger