Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs.
OBJECTIVE
To determine whether routine vaccination induces antibodies against bovine thyroglobulin and autoantibodies against canine thyroglobulin in dogs.


METHODS
Prospective study.


METHODS
20 healthy research Beagles and 16 healthy pet dogs.


METHODS
For the research Beagles, 5 dogs were vaccinated with a multivalent vaccine and a rabies vaccine, 5 dogs received only the multivalent vaccine, 5 dogs received only the rabies vaccine, and 5 dogs were unvaccinated controls. The multivalent vaccine was administered at 8, 10, 12, 16, 20, 26, and 52 weeks of age and every 6 months thereafter. The rabies vaccine was administered at 16 and 52 weeks of age and then once per year. Blood was collected from all dogs at 8, 16, and 26 weeks of age and then 4 times yearly. Assays for antibodies directed against bovine and canine thyroglobulin were performed prior to and 2 weeks after each yearly vaccination. For the pet dogs, blood was collected prior to and 2 weeks after 1 vaccination.


RESULTS
In the research Beagles, there was a significant increase in anti-bovine thyroglobulin antibodies in all vaccinated dogs, compared with control dogs. There was a significant increase in anti-canine thyroglobulin antibodies in the 2 groups of dogs that received the rabies vaccine but not in the group that received the multivalent vaccine alone. In the pet dogs, there was a significant increase in anti-canine thyroglobulin antibodies after vaccination but no significant change in anti-bovine thyroglobulin antibodies.


CONCLUSIONS
Recent vaccination may result in increased anti-canine thyroglobulin antibodies. Whether these antibodies have a deleterious effect on canine thyroid function is unknown.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
J Catharine
JC
Scott-Moncrieff
Juan
J
Azcona-Olivera
Nita W
NW
Glickman
Lawrence T
LT
Glickman
Harm
H
HogenEsch
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D002417:Cattle; D004283:Dog Diseases / Q000276:immunology / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D007037:Hypothyroidism / Q000139:chemically induced / Q000662:veterinary*; D007115:Immunization Schedule; D011446:Prospective Studies; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary; D011819:Rabies Vaccines / Q000276:immunology; D013954:Thyroglobulin / Q000096:biosynthesis / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary*; D017778:Vaccines, Combined / Q000276:immunology
D001323:Autoantibodies; D011819:Rabies Vaccines; D017778:Vaccines, Combined; C006606:anti-thyroglobulin; D013954:Thyroglobulin