Can olanzapine be implicated in causing serotonin syndrome?
The present paper describes a case of serotonin syndrome (SS), which developed in a patient with bipolar affective disorder after the addition of olanzapine to her regimen of lithium and citalopram. This appears to be the first report that implicates olanzapine with SS. Clinicians should be aware of the risk of SS when adding atypical antipsychotics, such as olanzapine, to serotonergic agents.
Department of Psychiatry, Rotorua Hospital, Rotorua, New Zealand. cdhaslett@paradise.net.nz
Christopher David
CD
Haslett
Shailesh
S
Kumar
D014150:Antipsychotic Agents / Q000627:therapeutic use; D001569:Benzodiazepines; D001714:Bipolar Disorder / Q000188:drug therapy*; D015283:Citalopram / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018021:Lithium Chloride / Q000627:therapeutic use; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012307:Risk Factors; D020230:Serotonin Syndrome / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D015283:Citalopram; D018021:Lithium Chloride; D000077152:Olanzapine; D010890:Pirenzepine; D017367:Selective Serotonin Reuptake Inhibitors