The neuroanatomical substrate of sound duration discrimination.
We investigated the neuroanatomical substrate of sound duration discrimination, using the same experimental design as in a previous study on sound intensity discrimination [J. Neurosci. 18 (16) (1998) 6388]. Seven normal subjects were trained to detect deviant sounds presented with a slightly longer duration than a 300 ms long standard harmonic sound, using a Go/No Go paradigm. Individual psychometric curves were assessed using a three-step psychoacoustic procedure. Subjects were then scanned while passively listening to the standard sound, and while discriminating changes in sound duration at four different performance levels (d'=1.5, 2.5, 3.5 and 4.5). Analysis of regional cerebral blood flow (rCBF) data outlined activation, during the discrimination conditions, of a right hemispheric fronto-parietal network very similar to the one previously observed for intensity discrimination, as well as additional activation in the right prefrontal cortex (Brodmann Area (BA) 10), bilateral basal ganglia and cerebellar hemispheres. These findings suggest that discrimination of sound duration, as for discrimination of sound intensity, involves two cerebral networks: a supramodal right fronto-parietal cortical network responsible for allocation of sensory attentional resources, and a network of regions such as the basal ganglia, cerebellum, and right prefrontal cortex, more specifically involved in the temporal aspects of the discrimination task.
Belin
Pascal
P
Groupe de Neurologie, CEA-SHFJ, DRM, 4 place du Général Leclerc, F-91406 Orsay Cedex, France. pascal.belin@umontreal.ca
McAdams
Stephen
S
Thivard
Lionel
L
Smith
Bennett
B
Savel
Sophie
S
Zilbovicius
Monica
M
Samson
Séverine
S
Samson
Yves
Y
D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001309:Auditory Threshold / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology*; D004192:Discrimination, Psychological / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D009474:Neurons / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D013998:Time Perception / Q000502:physiology; D014055:Tomography, Emission-Computed