8-Aryl xanthines potent inhibitors of phosphodiesterase 5.
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in many cases, high levels of selectivity versus other PDE isoforms.
Novartis Horsham Research Centre, Wimblehurst Road, West Sussex RH12 5AB, Horsham, UK.
Ruth
R
Arnold
David
D
Beer
Gurdip
G
Bhalay
Urs
U
Baettig
Stephen P
SP
Collingwood
Sarah
S
Craig
Nicholas
N
Devereux
Andrew
A
Dunstan
Angela
A
Glen
Sylvie
S
Gomez
Sandra
S
Haberthuer
Trevor
T
Howe
Stephen
S
Jelfs
Heinz
H
Moser
Reto
R
Naef
Paul
P
Nicklin
David
D
Sandham
Rowan
R
Stringer
Katharine
K
Turner
Simon
S
Watson
Mauro
M
Zurini
D008958:Models, Molecular; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000187:drug effects*; D014970:Xanthines / Q000737:chemistry / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D010727:Phosphoric Diester Hydrolases