Five new labdane diterpenes from Aster oharai.
Five new labdane diterpenes (1-5) together with seven known diterpenes have been isolated from a methanol extract of the aerial parts of Aster oharai. Five new structures were determined as 7alpha-hydroperoxylabda-8(17),14-dien-13(R)-ol-4-O-acetyl-alpha-L-6-deoxyidopyranoside (1), 7alpha-hydroperoxylabda-8,14-dien-13(R)-ol-4-O-acetyl-alpha-L-6-deoxyidopyranoside (2), labda-7,14-dien-13(R)-ol-4-O-acetyl-alpha-L-rhamnopyranoside (3), labda-7,14-dien-13(R)-ol-3-O-acetyl-alpha-L-rhamnopyranoside (4), and labda-7,14-dien-13(R)-ol-2-O-acetyl-alpha-L-rhamnopyranoside (5), on the basis of spectroscopic methods. Compound 1 showed moderate cytotoxicity against four cultured human tumor cell lines with ED(50) values ranging from 1.1 to 7.7 microg/mL.
Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon 440-746, Republic of Korea.
Sang Zin
SZ
Choi
Hak Cheol
HC
Kwon
Sang Un
SU
Choi
Kang Ro
KR
Lee
D019659:Asteraceae / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D015179:Colorectal Neoplasms; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007723:Korea; D008175:Lung Neoplasms; D008968:Molecular Conformation; D015394:Molecular Structure; D009423:Nervous System Neoplasms; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D010946:Plants, Medicinal / Q000737:chemistry*; D012878:Skin Neoplasms; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects; D001617:beta-Glucosidase / Q000378:metabolism
D004224:Diterpenes; C433017:labdane; D001617:beta-Glucosidase