Hb G Makassar (beta 6:Glu-Ala) in a Thai family.
Hemoglobin G Makassar was identified in a family of Thai origin, which was found to share identical properties with hemoglobin S in routine hemoglobin separation both by cellulose acetate electrophoresis and cation-exchange HPLC. It is, therefore, subjects with hemoglobin G Makassar and hemoglobin S who may sometimes be mistakenly identified for each other. In this study, identification of hemoglobin G Makassar was achieved by DNA sequence analysis, which revealed a single nucleotide substitution GAG-->GCG at codon 6 of the beta-globin gene. The hemoglobin variant was hemoglobin G Makassar [beta 6:Glu-->Ala]. This is the first report of hemoglobin G Makassar in Thailand.
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Siripakorn
S
Sangkitporn
Budsaba
B
Rerkamnuaychoke
Somchai
S
Sangkitporn
Chartchai
C
Mitrakul
Yavamal
Y
Sutivigit
D000328:Adult; D000409:Alanine / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005914:Globins / Q000235:genetics*; D018698:Glutamic Acid / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D017422:Sequence Analysis, DNA; D013785:Thailand
D006455:Hemoglobins, Abnormal; D018698:Glutamic Acid; D005914:Globins; D000409:Alanine