Mechanisms of transplant tolerance induction using costimulatory blockade.
The potential use of costimulation-blocking reagents to induce transplantation tolerance has recently created considerable excitement. Recent evidence has begun to delineate the mechanisms by which these powerful effects occur. It has become increasingly clear, firstly, that T cell costimulation is mediated by a delicate network of signaling pathways and, secondly, that interference with these systems can lead to numerous different tolerance mechanisms, including immune regulation, anergy and deletion.
The Division of Transplantation, Department of Surgery, Vienna General Hospital, University of Vienna, Waehringer Guertel 18, A 1090 Vienna, Austria. Thomas.Wekerle@akh-wien.ac.at
Thomas
T
Wekerle
Josef
J
Kurtz
Sinda
S
Bigenzahn
Yasuo
Y
Takeuchi
Megan
M
Sykes
D000069594:Abatacept; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000938:Antigen-Presenting Cells / Q000502:physiology; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000627:therapeutic use*; D017209:Apoptosis; D023201:CD40 Ligand / Q000502:physiology*; D060908:CTLA-4 Antigen; D006084:Graft Rejection; D006801:Humans; D018796:Immunoconjugates; D007165:Immunosuppression Therapy / Q000379:methods*; D013950:Thymus Gland / Q000502:physiology; D014181:Transplantation Immunology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018796:Immunoconjugates; D023201:CD40 Ligand; D000069594:Abatacept