Effects of stress on nonassociative learning processes in male and female rats.
In this study we assessed habituation and sensitization of the acoustic startle response (ASR) to discern whether intense, inescapable stress affects nonassociative learning differently in male and female rats. Rats were inescapably stressed 2 hours per day over 3 consecutive days. ASR magnitudes were measured at several times post-stress (1, 4, 8, and 15 days after cessation). Females generally showed greater ASR magnitudes (compared to males), but both sexes exhibited short and long-term habituation across the testing days. ASR magnitudes were only affected by stress in male subjects. The effect in males was an increase in short-term sensitization of the ASR on post-stress day-4. The results suggest that stressed males and females react differently to ASR testing, in that stress males appear to develop an exaggerated ASR response over repeated test sessions due to short-term sensitization. The source of the short-term sensitization is discussed with regards to possible stress-induced enhanced contextual learning during ASR testing on post-stress day-1.
Neurobehavioral Research Laboratory, Veterans Affairs New Jersey Health Care System, East Orange 07018, USA.
Kevin D
KD
Beck
Francis X
FX
Brennan
Richard J
RJ
Servatius
D000161:Acoustic Stimulation; D000818:Animals; D005260:Female; D006185:Habituation, Psychophysiologic; D007858:Learning / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013216:Reflex, Startle / Q000502:physiology*; D012737:Sex Factors; D013315:Stress, Psychological / Q000523:psychology*; D013997:Time Factors