Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors.
On the basis of molecular modelling studies, five new compounds were synthesised and studied in an attempt to design new lead structures as selective COX-2 inhibitors.
Park
Chang Ha
CH
Yang Ji Chemical Co., Ltd. 638-6, Sungkok-Dong, Ansan-City, Kyunggi-Do, South Korea.
Siomboing
Xavier
X
Yous
Saïd
S
Gressier
Bernard
B
Luyckx
Michel
M
Chavatte
Philippe
P
D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins; D008958:Models, Molecular; D008968:Molecular Conformation; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry / Q000378:metabolism*; D021281:Quantitative Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology; D013929:Thromboxane B2 / Q000378:metabolism
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007202:Indicators and Reagents; D007527:Isoenzymes; D008565:Membrane Proteins; D013449:Sulfonamides; D013929:Thromboxane B2; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; C012655:nimesulide