Competition and compensation: coupled to death in development and cancer.
Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "losers" in this process.
Abrams
John M
JM
Department of Cell Biology, University of Texas Southwestern Medical Center, 75390, USA. john.abrams@utsouthwestern.edu
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D019521:Body Patterning / Q000235:genetics; D002450:Cell Communication / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D002455:Cell Division / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
D029721:Drosophila Proteins