Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tü 6075. I. Taxonomy, fermentation, isolation and biological activities.
New lipopeptide antibiotics, colourless arylomycins A series and yellow arylomycins B series were detected in the culture filtrate and mycelium extracts of Streptomyces sp. Tü 6075 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. Arylomycins are a family of lipohexapeptide antibiotics, which represent the first examples of biaryl-bridged lipopeptides. They show antibiotic activities against Gram-positive bacteria.
Schimana
Judith
J
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
Gebhardt
Klaus
K
Höltzel
Alexandra
A
Schmid
Dietmar G
DG
Süssmuth
Roderich
R
Müller
Johannes
J
Pukall
Rüdiger
R
Fiedler
Hans-Peter
HP
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000737:chemistry / Q000235:genetics; D017422:Sequence Analysis, DNA; D012988:Soil Microbiology; D013302:Streptomyces / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D010456:Peptides, Cyclic; D012336:RNA, Ribosomal, 16S