The K469E polymorphism of the ICAM-1 gene is a risk factor for peripheral arterial occlusive disease.
Intercellular adhesion molecule-1 (ICAM-1) plays a crucial role in lymphocyte migration and activation, and is considered important in the pathogenesis of atherosclerosis. K469E is a common polymorphism of the ICAM-1 gene with potential functional significance. The aim of the present case-control study was to evaluate the association between this polymorphism and peripheral arterial occlusive disease (PAOD). ICAM-1 gene polymorphism was examined by polymerase chain reaction and restriction enzyme analysis in 75 Italian subjects affected by PAOD and 227 controls. The distribution of ICAM-1 genotypes in patients affected by PAOD was 32.1% EE, 50.6% EK, and 17.3% KK. The distribution of ICAM-1 genotypes in control subjects was 17.2% EE, 55.1% EK, and 27.7% KK. The EE genotype was significantly more common in patients than controls (P = 0.006). Logistic regression analysis indicated that the presence of the EE genotype significantly increases the risk of PAOD (odds ratio, 3.5; 95% confidence interval, 1.5-8.4; P = 0.004). This is the first study documenting a role of the ICAM-1 gene polymorphism in the pathogenesis of a cardiovascular disease, such as PAOD. Our data support the hypothesis that inflammatory mechanisms are important in the pathophysiology of vascular diseases with an atherosclerotic basis.
Gaetani
E
E
Department of Internal Medicine and Angiology, Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy. egaetani@hotmail.com
Flex
A
A
Pola
R
R
Papaleo
P
P
De Martini
D
D
Pola
E
E
Aloi
F
F
Flore
R
R
Serricchio
M
M
Gasbarrini
A
A
Pola
P
P
D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012307:Risk Factors
D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1