Axon guidance: proteins turnover in turning growth cones.
Accurate navigation by a neuronal growth cone requires the modulation of the growth cone's responsiveness to spatial and temporal changes in expression of guidance cues. These adaptations involve local protein synthesis and turnover in growth cones and distal axons.
Department of Neuroscience, University of Minnesota, 6-145 Jackson Hall, 321 Church St. SE, Minneapolis, MN 55455, USA.
Gianluca
G
Gallo
Paul
P
Letourneau
D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D002465:Cell Movement; D002630:Chemotactic Factors / Q000378:metabolism; D002645:Chickens; D020439:Growth Cones / Q000378:metabolism / Q000502:physiology*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000502:physiology; D014982:Xenopus laevis
D002630:Chemotactic Factors; D011506:Proteins