Metal insertion into NiFe-hydrogenases.
The synthesis and the insertion of the metallocentre of NiFe-hydrogenases is a complex process, in which seven maturation enzymes plus ATP, GTP and carbamoyl phosphate are involved. The review summarizes what is known about the properties and activities of these auxiliary proteins, and postulates a pathway along which maturation may take place.
Department Biologie I, Mikrobiologie, Universität München, Maria-Ward-Strasse 1a, D-80638 München, Germany.
M
M
Blokesch
A
A
Paschos
E
E
Theodoratou
A
A
Bauer
M
M
Hube
S
S
Huth
A
A
Böck
D004926:Escherichia coli / Q000201:enzymology; D006864:Hydrogenase / Q000096:biosynthesis*; D007501:Iron / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D009532:Nickel / Q000378:metabolism*; D021122:Protein Subunits / Q000378:metabolism
D008024:Ligands; D021122:Protein Subunits; D009532:Nickel; D007501:Iron; C043296:nickel-iron hydrogenase; D006864:Hydrogenase