All signaling is local?
The mechanism of signal transmission following ligand stimulation of receptor tyrosine kinases in living cells is poorly understood. Recent studies have visualized the spatio-temporal pattern of EGF signaling, indicating that receptor density is an important factor in the mechanism of lateral propagation of local EGF signaling.
Schlessinger
Joseph
J
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.
D002467:Cell Nucleus / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D015398:Signal Transduction
D008024:Ligands; D004815:Epidermal Growth Factor; D066246:ErbB Receptors