Hypolipidaemic activity of seaweed from Karachi coast.
During the present study, ethanol extracts of five seaweed species Solieria robusta, Iyengaria stellata, Colpomenia sinuosa, Spatoglossum asperum and Caulerpa racemosa at 10 mg/ 200 g body weight were tested for their hypolipidaemic activity. All the species significantly decreased the serum total cholesterol, triglyceride and low density lipoprotein cholesterol levels in normal, triton-induced and diet-induced hyperlipidaemic rats. Solieria robusta was found to be the most effective in reducing the lipid profile, particularly in diet-induced hyperlipidaemic rats. A beneficial effect of the ethanol extract of S. asperum was also found on cardiac and liver enzymes in diet-induced hyperlipidaemic rats.
Ara
Jehan
J
Department of Food Science and Technology, University of Karachi, Karachi-75270, Pakistan.
Sultana
Viqar
V
Qasim
Rashida
R
Ahmad
Viqar Uddin
VU
D000284:Administration, Oral; D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010154:Pakistan; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D012624:Seaweed / Q000737:chemistry*
D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D011092:Polyethylene Glycols; C016811:tyloxapol