Naturally occurring cembranes from an Australian sarcophyton species.
Naturally occurring cembranes 1-4 have been isolated from a Sarcophyton sp. These compounds have not previously been found to occur in nature but had been obtained as intermediates in a synthetic modification from tobacco. The absolute stereochemistries of 3 and 4 were determined. Compounds 1 and 2 inhibited the binding of [(3)H]8-cyclopentyl-1,3-dipropylxanthine to rat-brain adenosine A(1) receptors.
AstraZeneca R&D Griffith University, Brisbane, Australia 4111.
Ngoc Bich
NB
Pham
Mark S
MS
Butler
Ronald J
RJ
Quinn
D000818:Animals; D001315:Australia; D001921:Brain / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria / Q000737:chemistry*; D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000187:drug effects; D013237:Stereoisomerism; D014970:Xanthines / Q000494:pharmacology
C466241:11,12-epoxy-2,6-cembrane-4,8-diol; D004224:Diterpenes; D018047:Receptors, Purinergic P1; D014970:Xanthines; C037071:cembrane; C051360:1,3-dipropyl-8-cyclopentylxanthine