Prevalence of aneuploidies in South Carolina in the 1990s.
OBJECTIVE
Folate insufficiency due to nutritional deficiency or folate processing gene mutations has been proposed as a trisomy 21 risk factor. This study examined the possibility that increased folic acid intake among women of childbearing age may decrease the prevalence of trisomy 21 and other aneuploidies.


METHODS
The prevalence of aneuploidies from 1990 through 1999 was compared with folic acid use in women of childbearing age in South Carolina.


RESULTS
Folic acid use and the prevalence of all aneuploidies significantly increased during this period.


CONCLUSIONS
Increased folic acid utilization in South Carolina was not associated with decreased prevalence of trisomy 21 or other aneuploidies.
Collins
Julianne S
JS
Greenwood Genetic Center, 1 Gregor Mendel Circle, Greenwood, SC 29646, USA.
Olson
Rick L
RL
DuPont
Barbara R
BR
Wolff
Daynna J
DJ
Best
Robert G
RG
Stevenson
Roger E
RE
D000782:Aneuploidy; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000453:epidemiology; D005260:Female; D005492:Folic Acid / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D013022:South Carolina / Q000453:epidemiology
D005492:Folic Acid