Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent North American isolates of Streptococcus pneumoniae.
The activity of AZD2563 against 250 highly resistant pneumococci and 267 drug-susceptible isolates was determined. The AZD2563 MICs for 50 and 90% of the strains tested were 1 and 2 micro g/ml and 0.5 and 1 micro g/ml, respectively, for the two isolate groups. These MICs were within 1 log(2) dilution of those of linezolid.
Infectious Disease Service of Brooke Army Medical Center, San Antonio, Texas, USA.
Sue E
SE
Baum
Sharon A
SA
Crawford
M L
ML
McElmeel
Cynthia G
CG
Whitney
James H
JH
Jorgensen
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009656:North America; D023303:Oxazolidinones / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; C453362:posizolid; D000069349:Linezolid