Altering prion replication for therapy and diagnosis of transmissible spongiform encephalopathies.
Transmissible spongiform encephalopathies, also known as prion-related diseases, are a group of fatal neurodegenerative disorders associated with the misfolding of the prion protein. In this article, the potential use of the principles of prion replication to develop novel therapeutic and diagnostic strategies for these devastating diseases are described.
Soto
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Serono International, Geneva, Switzerland. Claudio.Soto@serono.com
D006801:Humans; D017096:Prion Diseases / Q000175:diagnosis* / Q000628:therapy*; D011328:Prions / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D011487:Protein Conformation; D012106:Research / Q000639:trends
D011328:Prions