Differences between rats and mice in induction of 4S beta-naphthoflavone-binding protein expression by treatment with beta-naphthoflavone.
Sprague-Dawley rats and several inbred strains of mice were compared with respect to the induction of 4S BNF-binding protein expression by treatment with beta-naphthoflavone (BNF), an aryl hydrocarbon receptor (AhR) ligand. Inbred strains of mice chosen for the study encompassed 3 allelic forms of AhR found in Mus musculus so far. As it was reported by us earlier, treating rats with BNF caused a significant induction of BNF-binding protein expression. By contrast, no BNF-binding protein was detected in mice treated with BNF in corn oil as a vehicle or with corn oil itself.
Institute of Human Genetics, Polish Academy of Sciences, ul. Strzeszyńska 32, 60-479 Poznań, Poland. brauzdam@man.poznan.pl
Damian
D
Brauze
Radosław
R
Januchowski
Krzysztof
K
Szyfter
D000818:Animals; D050938:Glycine N-Methyltransferase; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008861:Microsomes / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism; D013045:Species Specificity; D019324:beta-Naphthoflavone / Q000494:pharmacology*
D018336:Receptors, Aryl Hydrocarbon; D019324:beta-Naphthoflavone; D008780:Methyltransferases; D050938:Glycine N-Methyltransferase