Selectivity via cooperative interactions: detection of dicarboxylates in water by a pinwheel chemosensor.
The recognition properties of a cooperative pinwheel chemosensor for dicarboxylates are described. The sensor possesses four guanidinium recognition elements to cooperatively bind two dicarboxylates of varying size. The effect of cooperativity and the read-out mechanism contributes to favorable binding constants for dicarboxylates in water, as well as a high degree of selectivity over monocarboxylates. Appropriate methods of reporting affinity for cooperative systems are discussed.
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Joseph
J
Raker
Timothy E
TE
Glass
D000465:Algorithms; D000596:Amino Acids; D001665:Binding Sites; D015374:Biosensing Techniques; D003998:Dicarboxylic Acids / Q000737:chemistry* / Q000493:pharmacokinetics*; D005456:Fluorescent Dyes; D019791:Guanidine / Q000737:chemistry; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000596:Amino Acids; D003998:Dicarboxylic Acids; D005456:Fluorescent Dyes; D011084:Polycyclic Aromatic Hydrocarbons; D014867:Water; D019791:Guanidine