Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies.
To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n=365) or low-grade squamous epithelial lesions (LSILs; n=275) or who were cytologically normal (control subjects; n=681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.
Wang
Sophia S
SS
Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7234, USA. wangso@mail.nih.gov
Hildesheim
Allan
A
Gao
Xiaojiang
X
Schiffman
Mark
M
Herrero
Rolando
R
Bratti
M Concepcion
MC
Sherman
Mark E
ME
Barnes
Willard A
WA
Greenberg
Mitchell D
MD
McGowan
Larry
L
Mortel
Rodrigue
R
Schwartz
Peter E
PE
Zaino
Richard J
RJ
Glass
Andrew G
AG
Burk
Robert D
RD
Karacki
Peter
P
Carrington
Mary
M
D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D015331:Cohort Studies; D003364:Costa Rica; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D009922:Oregon; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology; D030361:Papillomavirus Infections / Q000235:genetics / Q000276:immunology; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000276:immunology* / Q000821:virology
D004279:DNA, Viral; D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I