Combinatorial and rational strategies to develop nonpeptidic alpha4beta7-integrin antagonists from cyclic peptides.
Gottschling
Dirk
D
Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85 747 Garching, Germany.
Boer
Jürgen
J
Schuster
Anja
A
Holzmann
Bernhard
B
Kessler
Horst
H
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D016023:Integrins / Q000037:antagonists & inhibitors*; D008968:Molecular Conformation; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*
D016023:Integrins; D010456:Peptides, Cyclic; C071777:integrin alpha4beta7