Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase.
For growth under oxygen-free atmosphere, some strict or facultative anaerobes depend on a class III ribonucleotide reductase for the synthesis of deoxyribonucleotides, the DNA precursors. Prototypes for this class of enzymes are ribonucleotide reductases from Escherichia coli and bacteriophage T4. This review article describes their structural and mechanistic properties as well as their complex allosteric regulation. Their evolutionnary relationship to class I and class II ribonucleotide reductases is also discussed.
Laboratoire de Chimie et Biochimie des Centres Rédox Biologiques, UMR CNRS/CEA/Université Joseph DRDC-CB, CEA Grenoble, France.
Marc
M
Fontecave
Etienne
E
Mulliez
Derek T
DT
Logan
D000595:Amino Acid Sequence; D000693:Anaerobiosis; D001421:Bacteria, Anaerobic; D001426:Bacterial Proteins; D004247:DNA; D003854:Deoxyribonucleotides / Q000096:biosynthesis*; D029968:Escherichia coli Proteins; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D012313:RNA; D012264:Ribonucleotide Reductases / Q000235:genetics / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D003854:Deoxyribonucleotides; D029968:Escherichia coli Proteins; D014764:Viral Proteins; D012313:RNA; D004247:DNA; C490362:NrdG protein, E coli; D012264:Ribonucleotide Reductases; C101141:anaerobic ribonucleotide reductase; C490361:nrdG protein, Enterobacteria phage T4; C090389:nrdG protein, bacteria