Daphmanidin A, a novel hexacyclic alkaloid from Daphniphyllum teijsmanii.
A novel alkaloid with an unprecedented fused-hexacyclic skeleton, daphmanidin A (1), and a new pentacyclic alkaloid, daphmanidin B (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was determined by combination of NOESY correlations and a modified Mosher method.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
Jun'ichi
J
Kobayashi
Satoshi
S
Ueno
Hiroshi
H
Morita
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D007938:Leukemia; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006576:Heterocyclic Compounds, 4 or More Rings; C472465:daphmanidin A; C472466:daphmanidin B