Atroviridins A-C and neoatroviridins A-D, novel peptaibol antibiotics produced by Trichoderma atroviride F80317. I. Taxonomy, fermentation, isolation and biological activities.
Seven new peptaibols, atroviridins A-C composed of 20 residue amino acids and neoatroviridins A-D with 18 residues, were isolated from the culture broth of fungal strain F80317. The strain F80317 was identified as Trichoderma atroviride from its morphological and cultural characteristics. These compounds showed antimicrobial activity against Gram-positive bacteria and phytopathogenic fungi, and exhibited significant cytotoxicity to human cancer cell lines in vitro. Atroviridins showed significant membrane-perturbing activity responsible to their antibiotic action.
Oh
Seung-Uk
SU
Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
Yun
Bong-Sik
BS
Lee
Sang-Jun
SJ
Kim
Jung-Han
JH
Yoo
Ick-Dong
ID
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D020014:K562 Cells; D008826:Microbial Sensitivity Tests; D010455:Peptides; D014242:Trichoderma / Q000737:chemistry* / Q000166:cytology / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010455:Peptides