Aptamer rivalry.
A controllable, intracellular RNA aptamer could be an invaluable therapeutic or discovery reagent. A report published in this journal shows that aptamer behavior can be regulated by a small molecule, paving the way for the development of more sophisticated ligand-regulated aptamers.
Sen
Dipankar
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Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
D000818:Animals; D006801:Humans; D008024:Ligands; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000037:antagonists & inhibitors; D012313:RNA / Q000737:chemistry* / Q000187:drug effects / Q000627:therapeutic use; D016337:RNA, Catalytic
D008024:Ligands; D011506:Proteins; D016337:RNA, Catalytic; D012313:RNA