[Effect of the substances "Ammivit" and "cerloplasmin" on lipid peroxidation products level and of antioxidant system indicators under irradiation].
It has been shown, that the total X-ray irradiation in the dozes of 0.5 and 1 Gy influences on the content of lipid peroxidation products and enzymatic activity of antioxidant system in rat spleen and thymus cells. The influence of preparations "AMMIVIT" and "Ceruloplasmin" on these processes is investigated also. So, the animals feeding by the vitamin concentrate "AMMIVIT" have lead to increase of MDA level (a final product of lipid peroxidation) and the overactivity of some antioxidant enzymes in rat spleen and thymus cells. Injection of the preparation "Ceruloplasmin" to experimental animals up 1 hour before the irradiation has normalized LPO intensity and activity of AO enzymes.
Taras Shevchenko Kyiv National University, Ukraine.
O P
OP
Hadiliia
T R
TR
Andriĭchuk
S P
SP
Merkulov
L I
LI
Ostapchenko
M E
ME
Kucherenko
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D002570:Ceruloplasmin / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects
D000975:Antioxidants; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D002570:Ceruloplasmin