The erythrocyte adhesiveness/aggregation test for the detection of an acute phase response and for the assessment of its intensity.
We have developed a simple slide test and image analysis to reveal the state of erythrocyte adhesiveness/aggregation in the peripheral blood of patients with various degrees of the humoral acute phase response. The significant correlation between the results of the erythrocyte adhesiveness/aggregation test (EAAT), the erythrocyte sedimentation rate and fibrinogen concentration support the notion that it is possible to use the EAAT as a marker for the intensity of the acute phase response. Within a group of 860 individuals, we were able to differentiate effectively between groups of patients with a different intensity of humoral acute phase response. The present study confirms previous observations that support the applicability of the EAAT to routine clinical practice.
Department of Internal Medicine 'D', Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel.
N
N
Maharshak
I
I
Shapira
R
R
Rotstein
J
J
Serov
S
S
Aharonov
T
T
Mardi
A
A
Twig
A
A
Rubinstein
M
M
Kofler
S
S
Berliner
D
D
Zeltser
D000210:Acute-Phase Reaction / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D016022:Case-Control Studies; D002448:Cell Adhesion; D003952:Diagnostic Imaging / Q000379:methods* / Q000592:standards; D004903:Erythrocyte Aggregation; D004912:Erythrocytes / Q000166:cytology*; D005240:Feasibility Studies; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007249:Inflammation / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D005340:Fibrinogen