No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment.
We investigated the association between serotonergic polymorphisms and incidence of nausea, which is the most frequent side-effect of selective serotonin reuptake inhibiters (SSRIs), in 66 patients treated with fluvoxamine in a protocolized-dosing method. We focused on three polymorphisms of serotonin (5-HT) neuronal systems such as 5-HT transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), a variable number of tandem repeat (VNTR) polymorphism in the second intron of the 5-HTT gene (STin2) and tryptophan hydroxylase (TPH) gene polymorphism in intron 7 (TPH-A218C), which have been reported to possess positive association with treatment response to SSRIs. In addition to this, the relationship between development of nausea and treatment response was also analyzed. Results suggested that these three polymorphisms did not affect the development of fluvoxamine-induced nausea, and that incidence of nausea was not a phenomenon that predicts the treatment response to fluvoxamine.
Department of Psychiatry, Akita University School of Medicine, 1-1-1, Hondo, 010-8543, Akita, Japan. hito.takahashi@hotmail.com
Hitoshi
H
Takahashi
Keizo
K
Yoshida
Kenich
K
Ito
Kazuhiro
K
Sato
Mitsuhiro
M
Kamata
Hisashi
H
Higuchi
Tetsuo
T
Shimizu
Kunihiko
K
Ito
Kazuyuki
K
Inoue
Takehiko
T
Tezuka
Toshio
T
Suzuki
Tadashi
T
Ohkubo
Kazunobu
K
Sugawara
D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002352:Carrier Proteins / Q000235:genetics*; D016009:Chi-Square Distribution; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D009325:Nausea / Q000139:chemically induced*; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins; D014365:Tryptophan Hydroxylase / Q000235:genetics
D018687:Antidepressive Agents, Second-Generation; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D014365:Tryptophan Hydroxylase; D016666:Fluvoxamine