Sulfonamides and sulfonylated derivatives as anticancer agents.
The sulfonamides constitute an important class of drugs, with several types of pharmacological agents possessing antibacterial, anti-carbonic anhydrase, diuretic, hypoglycemic and antithyroid activity among others. A host of structurally novel sulfonamide derivatives have recently been reported to show substantial antitumor activity in vitro and/or in vivo. Although they have a common chemical motif of aromatic/heterocyclic sulfonamide, there are a variety of mechanisms of their antitumor action, such as carbonic anhydrase inhibition, cell cycle arrest in the G1 phase, disruption of microtubule assembly, functional suppression of the transcriptional activator NF-Y, and angiogenesis (matrix metalloproteinase, MMP) inhibition among others. Some of these compounds selected via elaborate preclinical screenings or obtained based on computer-aided drug design, are currently being evaluated in clinical trials. This review summarizes recent classes of sulfonamides and related sulfonyl derivatives disclosed ultimately as effective tumor cell growth inhibitors, or for the treatment of different types of cancer.
Università degli Studi di Firenze, Dipartimento di Chimica, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, Florence, I-50121, Italy.
Angela
A
Casini
Andrea
A
Scozzafava
Antonio
A
Mastrolorenzo
Laudiu T
LT
Supuran
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry; D002256:Carbonic Anhydrases / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D013424:Sulfanilamides / Q000737:chemistry / Q000627:therapeutic use; D013429:Sulfatases / Q000037:antagonists & inhibitors; D013449:Sulfonamides / Q000737:chemistry / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D013424:Sulfanilamides; D013449:Sulfonamides; D013429:Sulfatases; C020121:estrone sulfatase; D002256:Carbonic Anhydrases