Surface properties of calcium phosphate particles for self setting bone cements.
Calcium phosphate cements (CPC), consist of multicomponent powder mixtures of calcium orthophosphates with grain sizes in the region of 1-20 microm. Due to the small particle sizes surface properties as the zeta potential and adsorption processes play a significant role during manufacturing and application. In the context of this work zeta potentials of different calcium phosphates, like dicalcium phosphate anhydride (DPCA) tetracalcium phosphate (TTCP) and hydroxyapatite were measured in various organic/aqueous media with different pH values. The results show a strong dependency of the zeta potential on the kind of suspension medium used associated with different milling properties. The addition of sodium phosphate leads to a pH value dependent stabilization of the particles in the liquid phase; the zeta potential of the surface increases from about -15 to -18 mV in water and from -35 to -45 mV in 0.05 mol/l sodium phosphate solution. Besides the interaction of particles with various antibiotics was determined on the basis of the zeta potential of the surface. The substances partly cause a tremendous change of the surface load. This is accompanied by a change of the rheological properties of the cement paste, the morphology of the hardened cement matrix and a significant deterioration of the application-relevant properties as setting time or mechanical strength.
Gbureck
U
U
Functional Materials in Medicine and Dentistry, University of Würzburg, Am Pleicherwall 2, D-97070 Würzburg, Germany. uwe.gbureck@ezm.uni-wuerzburg.de
Probst
J
J
Thull
R
R
D000900:Anti-Bacterial Agents / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002484:Cementation / Q000379:methods; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing / Q000379:methods*; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry; D055672:Static Electricity; D013499:Surface Properties; D013718:Tensile Strength; D014867:Water / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D002130:Calcium Phosphates; D010710:Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D014867:Water; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; C018279:sodium phosphate