[Polycystic ovary syndrome: recent genetic contributions].
Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age. It is characterized by hyperandrogenism, chronic anovulation and it is often associated with hyperinsulinemia, insulin resistance and dyslipidaemia. The pathophysiology of polycystic ovary syndrome seems to implicate primary defects in ovarian steroidogenesis, influenced by environment, insulin action and obesity. Polycystic ovary syndrome is probably both a multigenetic and environmental disease. Knowing the genes of polycystic ovary syndrome would be helpful to develop therapeutics and prevention. Genes of gonadotrophins, steroid hormone synthesis and insulin resistance seem not to be directly involved, except perhaps the CYP 11 a gene. On the other hand, identification of the signal transduction pathways involved in these genes may provide valuable information that can be applied to other clinical manifestations of polycystic ovary syndrome (follicular growth arrest, insulin resistance, obesity and endometrial cancer...).
Jonard
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Service d'endocrinologie et de diabétologie, clinique Marc-Linquette, USN A, CHU, 6, rue du professeur Laguesse, 59037 Lille, France.
Dewailly
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D
D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000235:genetics; D016889:Endometrial Neoplasms / Q000150:complications / Q000235:genetics; D005260:Female; D006062:Gonadotropins / Q000235:genetics; D006728:Hormones / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D009765:Obesity / Q000150:complications / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000235:genetics*; D015398:Signal Transduction; D013256:Steroids / Q000096:biosynthesis
D006062:Gonadotropins; D006728:Hormones; D013256:Steroids; D002786:Cholesterol Side-Chain Cleavage Enzyme