[Cerebral protective effects of some compounds isolated from traditional Chinese herbs].
OBJECTIVE
To study the cerebral protective effects of some compounds isolated from traditional Chinese herbs.


METHODS
Laser microcirculation dynamic analyzer and cultured rat cortical neurons were used.


RESULTS
Pueraria lobata flavonoids(LPF), Panax notoginseng saponins(PNS), oxymatrine, anisodamine and berberine could dilate microvessels and increase the cerebral blood flow of anesthetized mice's meninges. LPF, PNS, oxymatrine, and anisodamine also accelerated the flow of blood. Oxymatrine, like anisodamine, increased quantities of erythrocytes in high frequency movements. PNS could protect cultured rat cortical neurons from glutamate neurotoxicity.


CONCLUSIONS
LPF, PNS, oxymatrine, anisodamine and berberine have certain protective effects on brain, but differ in mechanisms of action.
Institute of Medicinal Plants, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094.
L
L
Ma
P
P
Xiao
B
B
Guo
J
J
Wu
F
F
Liang
S
S
Dong
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D001599:Berberine / Q000494:pharmacology; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008833:Microcirculation / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029908:Pueraria / Q000737:chemistry; D011807:Quinolizines; D051381:Rats; D012991:Solanaceous Alkaloids / Q000494:pharmacology; D000093842:Matrines
D000470:Alkaloids; D001599:Berberine; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D036145:Ginsenosides; D018696:Neuroprotective Agents; D011807:Quinolizines; D012991:Solanaceous Alkaloids; C003922:anisodamine; C037573:oxymatrine; D000093842:Matrines