[Secondary medullary aplasia from accidental radiation:therapeutic options and evolution of the concept].
Bone marrow grafting following accidental irradiation exposure should be viewed in the perspective of a severe myeloablative syndrome linked to high medullary damage for a dose range higher than 6-8 Gy, resulting in very late or no recovery. Prognosis will depend on the presence or absence of radio-combined injuries, the toxicity of the transplant procedure, and the risk of rejection induced by insufficient percritical immunosuppression. It is in this context that new cell therapy modalities, which combine enhanced peripheral hematopoietic cell engraftment and high immunosuppressive conditioning regimen with low extrahematological toxicity, inducing early and stable mixed lymphomyeloid chimerism with minimal morbidity, can be considered. Such an approach is being evaluated in the treatment of patients with hematological malignancies at high risk of transplant-related mortality using conventional bone marrow methods.
Service d'Hématologie, HIA Percy, Fontenay-aux-Roses, France. hematologie.percy@wanadoo.fr
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T
de Revel
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Fagot
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B
Souleau
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D
Dormont
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Nedellec
D016026:Bone Marrow Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D018788:Radioactive Hazard Release; D012010:Red-Cell Aplasia, Pure / Q000601:surgery*