[Effect of po li gan capsule on immunofunction in mice].
This study aimed at the immune response of mice to Po Li Gan Capsule (PLGC). The effects of PLGC on phagocytosis of phagocyte, on serum hemolysin, and on IL-1, IL-2 in mice were investigated. The results showed that the coefficient and index of phagocytosis obviously increased in the experiment group, compared with that in the control group (P < 0.01); the serum hemolysin in the experiment group increased too (P < 0.01). The results also showed that PLGC could restore the capacity of macrophage for secreting IL-1 that had been inhibited by cyclophosphamide and PLGC could enhance the release of IL-2 from spleen cell in the experiment group (P < 0.05-0.01). These suggest that PLGC enhances both cellular and humoral immunity function in mice.
Department of Pharmacology, School of Basic Medical Sciences, WCUMS, Chengdu 610041.
J
J
Chen
S
S
Cai
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D
Bao
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry; D027885:Astragalus propinquus; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006460:Hemolysin Proteins / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D005894:Panax / Q000737:chemistry; D010587:Phagocytosis; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation
D000276:Adjuvants, Immunologic; D002214:Capsules; D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; D007375:Interleukin-1; D007376:Interleukin-2; D011134:Polysaccharides; C027492:Huang Qi