[Fructose-bisphosphatase of microorganisms].
Data from modern scientific literature concerning general characteristics of fructose-bisphosphatase--the key enzyme of microorganisms gluconeogenesis pathway have been analyzed in the survey. The conditions of fructose-bisphosphatase functioning in the cell--activation and repression, have been described. Regulation of prokaryotes enzyme activity by fructose-1.6-bisphosphate, fructose-2.6-bisphosphate, phosphoenol pyruvate, metal cation, etc., is discussed. Absolute dependence of fructose-bisphosphatase activity on cations of bivalent metals (Mg2+, Mn2+) and AMP is shown. Special attention was given to the functioning and characteristics of the enzyme in prokaryotes and eukaryotes: their similarity and differences. Data about the basic enzyme of gluconeogenesis pathway in Gram-positive and Gram-negative microorganisms, conditions of its functioning in autotrophs and heterotrophs have been generalized for the first time. Genetical and molecular biological properties of fructose-bisphosphatase in microorganisms have been considered. At the same time, the fact is established that the above enzyme has not been investigated in numerous microorganisms.
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
I G
IG
Skrypal'
O V
OV
Iastrebova
D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000737:chemistry / Q000235:genetics; D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D005057:Eukaryotic Cells / Q000378:metabolism; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005943:Gluconeogenesis; D008969:Molecular Sequence Data; D011387:Prokaryotic Cells / Q000201:enzymology
D001426:Bacterial Proteins; D002352:Carrier Proteins; C112406:fibrinogen-binding protein, Streptococcus equi; D006597:Fructose-Bisphosphatase