FAIR and dynamic susceptibility contrast-enhanced perfusion imaging in healthy subjects and stroke patients.
OBJECTIVE
To compare dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) and the flow-sensitive alternating inversion recovery (FAIR) technique for measuring brain perfusion.


METHODS
We investigated 12 patients with acute stroke, and 10 healthy volunteers with FAIR and DSC maps of regional cerebral blood volume (rCBV), mean transit time (MTT), and regional cerebral blood flow (rCBF).


RESULTS
In volunteers good gray/white-matter contrast was observed in FAIR, rCBF, and rCBV maps. Regions with high signal intensities in FAIR matched well with high values of rCBV and rCBF. In ischemic stroke patients a high correlation (r = 0.78) of the ipsi- to contralateral signal intensity ratios in FAIR and rCBF was observed in areas with perfusion abnormalities. In contrast, FAIR and rCBV (r = 0.50), and FAIR and MTT (r = -0.22) correlated only modestly. Furthermore, FAIR and rCBF demonstrated similar sizes of perfusion abnormality.


CONCLUSIONS
This study demonstrates for the first time that FAIR and rCBF depict similar relations of perfusion in ischemic stroke patients and healthy subjects.
Hunsche
Stefan
S
Department for Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany. s.hunsche@uni-koeln.de
Sauner
Dieter
D
Schreiber
Wolfgang G
WG
Oelkers
Peter
P
Stoeter
Peter
P
D000208:Acute Disease; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D020521:Stroke / Q000503:physiopathology*
D003287:Contrast Media