The scientific rationale and development of an optimized stannous fluoride dentifrice, Part 1.
Stannous fluoride has been recognized as an effective anticavity therapeutic agent since the early 1950s. There has recently been a resurgence in activity to discover ways to fully exploit its documented antimicrobial activity. Through the use of targeted in vitro methodology to predict in vivo efficacy, a highly optimized stannous fluoride dentifrice has been developed. Careful selection of stabilizing agents formulated into a unique system has resulted in a Colgate Optimized Stannous Fluoride (COSF) dentifrice that has been proven to simultaneously help control supragingival plaque, gingivitis, supragingival calculus, and caries. Furthermore, the COSF dentifrice has been clinically shown not to cause the traditional stannous fluoride staining of dentition.
Colgate-Palmolive Technology Center, Piscataway, New Jersey, USA.
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Williams
D001419:Bacteria / Q000187:drug effects; D001422:Bacterial Adhesion; D001682:Biological Availability; D002327:Cariostatic Agents / Q000737:chemistry / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D003728:Dental Calculus / Q000517:prevention & control; D003731:Dental Caries / Q000517:prevention & control; D003741:Dental Deposits / Q000382:microbiology; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D005079:Excipients / Q000737:chemistry; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D012463:Saliva / Q000382:microbiology / Q000502:physiology; D017971:Tin Compounds / Q000737:chemistry; D014002:Tin Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D014003:Tin Polyphosphates / Q000737:chemistry; D014075:Tooth Discoloration / Q000517:prevention & control
D002327:Cariostatic Agents; D003802:Dentifrices; D005079:Excipients; D017971:Tin Compounds; D014002:Tin Fluorides; D014003:Tin Polyphosphates; C023599:stannous chloride