The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies.
Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines.
Cellular Parasitology Programme, Department of Zoology, University of Ibadan, Ibadan, Nigeria.
Roseangela I
RI
Nwuba
Olugbemiro
O
Sodeinde
Chiaka I
CI
Anumudu
Yusuf O
YO
Omosun
Alexander B
AB
Odaibo
Anthony A
AA
Holder
Mark
M
Nwagwu
D000293:Adolescent; D000818:Animals; D019138:Antibodies, Blocking / Q000097:blood; D000913:Antibodies, Protozoan / Q000097:blood*; D017951:Antigen Presentation; D001667:Binding, Competitive; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D017780:Malaria Vaccines / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology / Q000517:prevention & control; D020066:Merozoite Surface Protein 1 / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*
D019138:Antibodies, Blocking; D000913:Antibodies, Protozoan; D017780:Malaria Vaccines; D020066:Merozoite Surface Protein 1