[Fluoroquinolones in children].
The only currently recommended pediatric use of fluoroquinolones involves ciprofloxacine for treatment of pyocyanic infection in children with cystic fibrosis. The main contraindication for use of fluoroquinolones in children is arthrotoxicity. Notwithstanding they are occasionally used for serious infections when there is no other therapeutic alternative. In addition to cystic fibrosis, potential pediatric indications include multidrug-resistant salmonella and shigellosis, certain enterobacterial infections in newborns, complicated urinary tract infections, and severe multidrug-resistant bacterial infection especially in immunocompromised subjects. The availability of new quinolones against pneumococcus should have little impact on current therapeutic strategies for upper or lower respiratory tract infections since potential indications in children are limited. However when the new generation reaches the market, fluoroquinolones should offer new alternatives for treatment of penicillin-resistant pneumococcal meningitis. Studies comparing children and adults have shown that arthrotoxicity is approximately the same or only slightly higher. The main problem for assessment of adverse effects is that pediatricians often fail to report the limited number of cases in which fluoroquinoles have been prescribed. Regardless fluoroquinolones must remain a second or third line agent for treatment of severe infection in cases in which no other alternative especially by the oral route is available. Use must be restricted to situations in which the risks are outweighed by potential benefits. Limiting pediatric use will slow down the emergence of resistant bacteria.
Gendrel
D
D
Hôpital Saint Vincent de Paul, 82 Av Denfert-Rochereau, 75014 Paris, France. dominique.gendrel@svp.ap-hop-paris.fr
D002648:Child; D003550:Cystic Fibrosis / Q000150:complications; D004405:Dysentery, Bacillary / Q000188:drug therapy; D024841:Fluoroquinolones / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000188:drug therapy; D007592:Joint Diseases / Q000139:chemically induced; D016920:Meningitis, Bacterial / Q000188:drug therapy; D009164:Mycobacterium Infections / Q000188:drug therapy; D012480:Salmonella Infections / Q000188:drug therapy
D024841:Fluoroquinolones