Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells.
We studied 55 patients with stage-IIB osteosarcoma around the knee with respect to the expression of matrix metalloproteinase (MMP)-9 in the surviving tumour cells in surgical resection specimens. They were followed up for a minimum of 2.5 years. Factors significantly associated with poor overall survival were a high serum level of alkaline phosphatase at diagnosis and tumour cells expressing MMP-9 in the resection specimens. The only factor strongly associated with disease-free survival was the immunohistochemical status of tumour cells for MMP-9 in the resection specimens. The percentage of necrosis after chemotherapy failed marginally to reach statistical significance. On Cox regression analysis only MMP-9 remained significant for overall and disease-free survival.
Royal Orthopaedic Hospital, Birmingham, England.
A F
AF
Foukas
N S
NS
Deshmukh
R J
RJ
Grimer
D C
DC
Mangham
E G
EG
Mangos
S
S
Taylor
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001859:Bone Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D002648:Child; D019902:Chondrocytes / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D005266:Femoral Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D012516:Osteosarcoma / Q000378:metabolism* / Q000601:surgery; D011379:Prognosis; D013977:Tibia
D000469:Alkaline Phosphatase; D020780:Matrix Metalloproteinase 9