Platelet reactivity in spontaneously diabetic rats is independent from blood glucose and insulin levels.
Diabetes is associated with thrombotic disorders. Chemically induced and spontaneously induced diabetic animals and various in vitro tests have been used to reveal the prothrombotic state of diabetic patients. However, the results are not consistent. In the present study, platelet reactivity of spontaneously diabetic Goto-Kakizaki rats in vivo and in vitro was evaluated by laser-induced and shear-induced thrombosis models, which are physiologically relevant to thrombosis. Both results showed platelet hyperreactivity.
Taka
Tomomi
T
Laboratory of Physiology, Faculty of Nutrition, and High Technology Research Centre, Kobe Gakuin University, Kobe, Japan.
Ono
Hiroaki
H
Sasaki
Yasuto
Y
Seki
Junji
J
Yamamoto
Junichiro
J
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001792:Blood Platelets / Q000473:pathology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D015539:Platelet Activation; D010979:Platelet Function Tests; D051381:Rats; D011919:Rats, Inbred Strains; D019851:Thrombophilia / Q000097:blood / Q000209:etiology; D013927:Thrombosis / Q000097:blood / Q000209:etiology
D001786:Blood Glucose; D007328:Insulin