Survival-promoting functions of 14-3-3 proteins.
The 14-3-3 proteins are a family of phosphoserine/phosphothreonine-binding molecules that control the function of a wide array of cellular proteins. We suggest that one function of 14-3-3 is to support cell survival. 14-3-3 proteins promote survival in part by antagonizing the activity of associated proapoptotic proteins, including Bad and apoptosis signal-regulating kinase 1 (ASK1). Indeed, expression of 14-3-3 inhibitor peptides in cells is sufficient to induce apoptosis. Interestingly, these 14-3-3 antagonist peptides can sensitize cells for effective killing by anticancer agents such as cisplatin. Thus, 14-3-3 may be part of the cellular machinery that maintains cell survival, and targeting 14-3-3-ligand interactions may be a useful strategy to enhance the efficacy of conventional anticancer agents.
Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.
S C
SC
Masters
R R
RR
Subramanian
A
A
Truong
H
H
Yang
K
K
Fujii
H
H
Zhang
H
H
Fu
D048948:14-3-3 Proteins; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D020935:MAP Kinase Signaling System; D010750:Phosphoproteins / Q000502:physiology; D010766:Phosphorylation; D015398:Signal Transduction; D014446:Tyrosine 3-Monooxygenase / Q000502:physiology*
D048948:14-3-3 Proteins; D010750:Phosphoproteins; D014446:Tyrosine 3-Monooxygenase