A case of Sézary's syndrome associated with granulomatous lesions, myelodysplastic syndrome and transformation into CD30-positive large-cell pleomorphic lymphoma.
Sézary's syndrome (SS) is a leukaemic variant of mycosis fungoides, a cutaneous T-cell lymphoma showing distinct clinical, histological, immunological, and genotypic features. We report a 10-year follow-up of a patient with SS exhibiting unusual features such as granulomatous skin lesions, transformation to a CD30-positive large-cell pleomorphic T-cell lymphoma, and development of myelodysplastic syndrome and review the cases of SS reported in the literature with these unusual and rare complications.
Department of Dermatology, University of Zurich Medical School, Gloriastr. 31, CH-8091 Zurich, Switzerland.
P M
PM
Carrozza
W
W
Kempf
D V
DV
Kazakov
R
R
Dummer
G
G
Burg
D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000473:pathology; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology; D012751:Sezary Syndrome / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D017730:Ki-1 Antigen