[Specific parameters for the calculation of dose after aerosol inhalation of transuranium elements].
A review on specific parameter measurements to calculate doses per unit of incorporation according to recommendations of the International Commission of Radiological Protection has been performed for inhaled actinide oxides. Alpha activity distribution of the particles can be obtained by autoradiography analysis using aerosol sampling filters at the work places. This allows us to characterize granulometric parameters of "pure" actinide oxides, but complementary analysis by scanning electron microscopy is needed for complex aerosols. Dissolution parameters with their standard deviation are obtained after rat inhalation exposure, taking into account both mechanical lung clearance and actinide transfer to the blood estimated from bone retention. In vitro experiments suggest that the slow dissolution rate might decrease as a function of time following exposure. Dose calculation software packages have been developed to take into account granulometry and dissolution parameters as well as specific physiological parameters of exposed individuals. In the case of poorly soluble actinide oxides, granulometry and physiology appear as the main parameters controlling dose value, whereas dissolution only alters dose distribution. Validation of these software packages are in progress.
Laboratoire de Radiotoxicologie, CEA/DSV/DRR/SRCA, Bruyères le Châtel, France.
B
B
Ramounet-Le Gall
P
P
Fritsch
M C
MC
Abram
G
G
Rateau
G
G
Grillon
K
K
Guillet
S
S
Baude
P
P
Bérard
E
E
Ansoborlo
J
J
Delforge
D008671:Actinoid Series Elements / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D000280:Administration, Inhalation; D000336:Aerosols; D011874:Radiometry / Q000379:methods*; D012995:Solubility
D008671:Actinoid Series Elements; D000336:Aerosols