Two new triterpenoids from Azadirachta indica and their insecticidal activity.
Two new triterpenoids, 22,23-dihydronimocinol (1) and desfurano-6alpha-hydroxyazadiradione (2), were isolated from a methanolic extract of the fresh leaves of Azadirachta indica (neem) along with a known meliacin, 7alpha-senecioyl-(7-deacetyl)-23-O-methylnimocinolide. The structures of 1 and 2 were elucidated through spectral and chemical studies. Compounds 1 and 2 showed mortality for fourth instar larvae of the mosquito (Anopheles stephensi), with LC(50) values of 60 and 43 ppm, respectively.
Siddiqui
Bina S
BS
H.E.J. Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Pakistan. bina@khi.comsats.net.pk
Afshan
Farhana
F
Faizi
Shaheen
S
Naeem-Ul-Hassan Naqvi
Syed
S
Tariq
Rajput M
RM
D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C466700:22,23-dihydronimocinol; D007306:Insecticides; D014315:Triterpenes; C466701:desfurano-6alpha-hydroxyazadiradione