Two new minor polybrominated dibenzo-p-dioxins from the marine sponge Dysidea dendyi.
Two new minor tribromodibenzo-p-dioxins, spongiadioxin C (1) and its methyl ether (2), were isolated from an Australian marine sponge Dysidea dendyi, together with the known minor metabolites methyl ethers of spongiadioxins A (4) and B (6) and polybrominated diphenyl ethers (7-9). The structures of the new compounds were established by 1D and 2D NMR spectroscopy and confirmed by synthesis of 2 from diphenyl ether 9. All isolated compounds inhibited the cell division of fertilized sea urchin eggs.
Utkina
Natalia K
NK
Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok, Russia. utkinan@mail.ru
Denisenko
Vladimir A
VA
Virovaya
Marina V
MV
Scholokova
Olga V
OV
Prokof'eva
Nina G
NG
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004147:Dioxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004531:Eggs; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008745:Methylation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010647:Phenyl Ethers; D011161:Porifera / Q000737:chemistry*; D012617:Sea Urchins / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization
D004147:Dioxins; D006842:Hydrocarbons, Brominated; D010647:Phenyl Ethers; C433568:spongiadioxin A; C433569:spongiadioxin B; C466698:spongiadioxin C; C466699:spongiadioxin C, methyl ether; C031538:phenyl ether