Delivery of nascent polypeptides to the mitochondrial surface.
Thousands of polypeptides with diverse biochemical properties, some of which are extremely hydrophobic, are targeted from cytoplasmic ribosomes to the surface of mitochondria. Localised synthesis, as well as transient interactions with a wide array of molecular chaperones and other cytoplasmic factors, can promote productive interaction of mitochondrial proteins with the TOM complex to initiate protein import into mitochondria.
Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
Travis
T
Beddoe
Trevor
T
Lithgow
D002352:Carrier Proteins / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005057:Eukaryotic Cells; D007425:Intracellular Membranes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D024101:Mitochondrial Proteins / Q000096:biosynthesis / Q000378:metabolism*; D018832:Molecular Chaperones / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D014176:Protein Biosynthesis; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D012270:Ribosomes / Q000378:metabolism
D002352:Carrier Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D010455:Peptides; D011498:Protein Precursors