Performance of two commercial glycoprotein G-based enzyme immunoassays for detecting antibodies to herpes simplex viruses 1 and 2 in children and young adolescents.
In 61 patients 1 to 14 years of age, the Gull/Meridian enzyme-linked immunosorbent assay (ELISA) had a sensitivity of 100% for herpes simplex virus type 1 (HSV-1) and specificities of 74% for HSV-1 and 48% for HSV-2. In 128 similarly aged patients, the HerpeSelect ELISA (Focus Technologies) showed sensitivities of 80% for HSV-1 and 88% for HSV-2, and specificities of 97% for HSV-1 and 100% for HSV-2.
Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. leachc@uthscsa.edu
Charles T
CT
Leach
Rhoda L
RL
Ashley
Jacques
J
Baillargeon
Hal B
HB
Jenson
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006561:Herpes Simplex / Q000175:diagnosis* / Q000276:immunology; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D014759:Viral Envelope Proteins / Q000032:analysis* / Q000276:immunology
D011933:Reagent Kits, Diagnostic; D014759:Viral Envelope Proteins; C045464:glycoprotein G, herpes simplex virus type 2