A practical guide to targeted therapy for bone pain palliation.
Targeted radionuclide therapy is an effective and cost efficient treatment for multi-site metastatic bone pain. This paper discusses the physical characteristics of the licensed radiopharmaceuticals (153)Sm ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acid) ((153)Sm-EDTMP), (186)Re 1,1-hydroxyethylidenediphosphonate ((186)Re-HEDP) and (89)SrCl(2) and considers the factors influencing treatment choice in specific clinical settings. The advantages and practical limitations of this approach are discussed, with emphasis on defining criteria for patient selection and response monitoring. Opportunities for future research and development are outlined.
Lewington
V J
VJ
Nuclear Medicine Department, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK. vjlewington@hotmail.com
D001859:Bone Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000556:secondary*; D006801:Humans; D010146:Pain / Q000209:etiology; D059408:Pain Management; D010166:Palliative Care / Q000379:methods*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D016896:Treatment Outcome
D019275:Radiopharmaceuticals