Glycoconjugate libraries accessed by multicomponent reactions.
Glycobiology opens a wide field for new therapeutic approaches. However, the complexity and unavailability of various carbohydrate test compounds has excluded this class of natural products from modern screening systems. Alternatively, glycomimetics are considered to be more drug-like candidates for development. By means of multicomponent condensations (MCCs) utilizing suitable carbohydrate synthons, rapid and effective access to glycoconjugate libraries can be obtained. The flexibility of MCCs allows the assembly of diverse carbohydrate containing libraries. It may be assumed that MCCs containing carbohydrate moieties will play an important role in glycomimetic chemistry and biology.
Bayer AG, Central Research, ZF-WF, Q18, Simon Fraser University, D-51368 Leverkusen, Germany. oswald.lockhoff.ol@bayer-ag.de
Oswald
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Lockhoff
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D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D002264:Carboxylic Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003486:Cyanides / Q000737:chemistry; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D013698:Templates, Genetic
D000447:Aldehydes; D000588:Amines; D002264:Carboxylic Acids; D003486:Cyanides; D006001:Glycoconjugates