[5'-Nucleotidase and adenosine deaminase activity in the rat brain upon prolonged effect of low radiation doses].
The effect of combined low radiation doses (0.2-50.8 cGy) on the 5'-nucleotidase and adenosine deaminase activities in the rat hypothalamus, hippocamp and cerebral cortex during 45, 120 and 365 days was examined. It has been shown that the changes in the 5'-nucleotidase activity of the hypothalamus and hippocamp have a phase character. The direction of the changes in enzyme activity of the hypothalamus and hippocamp adenosine forming was dependent on the zone stay period and had the exactly opposite character depending on the early and prolonged stay period in the zone. 5'-nucleotidase activity was changed under the influence of mean and lesser doses with an increase of the zone stay period. No changes in the 5'-nucleotidase activity of the cerebral cortex were noted. No changes in the hypothalamic adenosine deaminase activity of rats that stayed in a zone during 45 days were revealed; under the effect of mean dose during 120 days the activity decreased and also in case of a higher dosage during one year. The adenosine deaminase activity in animal hippocamp decreased in rats only under the influence of the lesser dose, for 45-day period. The decrease in adenosine deaminase activity of the cerebral cortex that was noted under the effect of all the three doses during 45 days, the higher and mean doses during 120 days disappeared in a year.
Komisarenko Institute of Endocrinology and Metabolism of AMS, Ukraine.
L I
LI
Pil'kevykh
V Ia
VIa
Kononenko
M Iu
MIu
Alesina
D015720:5'-Nucleotidase / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D015720:5'-Nucleotidase; D000243:Adenosine Deaminase