Diterpenoids from Isodon adenantha.
Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha. The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X-ray crystallographic analysis of 11. Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC(50) values less than 4.0 microg/mL, respectively.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Republic of China.
Bei
B
Jiang
Hui
H
Yang
Ma-Lin
ML
Li
Ai-Jun
AJ
Hou
Quan-Bin
QB
Han
Su-Jun
SJ
Wang
Sheng-Hong
SH
Li
Han-Dong
HD
Sun
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia; D008518:Medicine, East Asian Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014057:Tomography, X-Ray Computed; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004224:Diterpenes; C466222:adenanthin F; C466118:calcicolin B; C466221:weisiensin A