Variable hemodynamic fluctuations during resection of multicentric extraadrenal pheochromocytomas.
OBJECTIVE
To report the perioperative management and the serious hemodynamic fluctuations during manipulation of an organ of Zuckerkandl tumour in a patient undergoing resection of multicentric extraadrenal pheochromocytomas.


RESULTS
A 28-yr-old man who had undergone at age 12 a laparotomy for excision of an extraadrenal pheochromocytoma complained of paroxysmal headache, occasional sweating and palpitations. The arterial blood pressure (BP) was 200/100 mmHg. A 24-hr-urine collection showed catecholamines 5076 microg x 24 hr(-1) (normal < 25 microg x 24 hr(-1)). Computed tomography of the abdomen revealed two retroperitoneal masses, one adjacent to the lower pole of the right kidney and a second larger mass located at the aortic bifurcation in the region of the organ of Zuckerkandl. The patient was scheduled for excision of multiple extraadrenal pheochromocytomas. He was prepared preoperatively for two weeks with prazosin 1 mg po q six hours and propranolol 10 mg tid. Manipulation of the infrarenal tumour was uneventful but manipulation of the Zuckerkandl tumour resulted in severe hypertensive episodes with BP ranging from 200/100 to 320/120 mmHg. Surgery was interrupted temporarily; the hypertensive crisis was controlled by the infusion of sodium nitroprusside and by iv phentolamine and esmolol.


CONCLUSIONS
In a patient undergoing resection of recurrent multicentric extraadrenal pheochromoctyomas, severe hypertensive episodes occurred during manipulation of one tumour but not during manipulation of the other. This may be attributed to inadequate preparation of the patient, difficult surgical dissection of the large Zuckerkandl pheochromocytoma, and/or secondary to an excessive and different pattern of release of catecholamines during manipulation of the Zuckerkandl tumour.
Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon. abaraka@aub.edu.lb
Anis
A
Baraka
Sahar
S
Siddik-Sayyid
Maya
M
Jalbout
Chadi
C
Yaacoub
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D019439:Chromaffin Cells; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000628:therapy*; D007431:Intraoperative Complications / Q000517:prevention & control; D007668:Kidney / Q000473:pathology / Q000601:surgery*; D008297:Male; D009364:Neoplasm Recurrence, Local; D010236:Paraganglioma, Extra-Adrenal / Q000503:physiopathology / Q000601:surgery*; D010673:Pheochromocytoma / Q000503:physiopathology / Q000601:surgery*; D011224:Prazosin / Q000627:therapeutic use*; D011292:Premedication; D011433:Propranolol / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D011433:Propranolol; D011224:Prazosin