To ERR in the estrogen pathway.
Estrogens control a variety of physiological and disease-linked processes, most notably reproduction, bone remodeling and breast cancer, and their effects are transduced through classic unclear receptors referred to as estrogen receptor-alpha (ER alpha) and ER beta. Recent results obtained using the estrogen-related receptors (ERR alpha, -beta and -gamma), a subfamily of orphan nuclear receptors closely related to the ERs, have shown that the ERRs share target genes, coregulatory proteins, ligands and sites of action with the ERs. In addition, the ERRs can actively influence the estrogenic response, suggesting that pharmacological modulation of ERR activity will be clinically useful to prevent and/or treat a variety of conditions related to women's health.
McGill University Health Center, 687 Pine Avenue West, Montréal, Québec, Canada H3A 1A1. vgiguere@dir.molonc.mcgill.ca
Vincent
V
Giguère
D016723:Bone Remodeling / Q000502:physiology; D001943:Breast Neoplasms / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D000097983:ERRalpha Estrogen-Related Receptor
D004958:Estradiol; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor; C490918:ESRRB protein, human; C490917:ESRRG protein, human; C107914:estrogen receptor-related receptor beta