Tuberous sclerosis with cystic renal disease and multifocal renal cell carcinoma in a baby girl.
An infant, in whom the prenatal diagnosis of tuberous sclerosis complex was made, presented with extreme bilateral nephromegaly owing to diffuse cystic changes. Histology of the resected non-functioning left kidney revealed, in addition to the characteristic cysts, two foci of renal cell carcinoma not visible on US or MRI. This infant is exceptional given the extensive cystic transformation of both kidneys and the presence of malignant lesions at this young age.
Breysem
Luc
L
Department of Radiology, University Hospitals, Herestraat 49, 3000 Leuven, Belgium. luc.brevsem@uz.kuleuven.ac.be
Nijs
Els
E
Proesmans
Willem
W
Smet
Maria-Helena
MH
D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D008279:Magnetic Resonance Imaging; D007690:Polycystic Kidney Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D014402:Tuberous Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014463:Ultrasonography