Surrogate estimates of insulin sensitivity in Chinese diabetic patients and their offspring.
OBJECTIVE
To evaluate the relationship between surrogate measures of insulin sensitivity and results from euglycaemic insulin clamp in Chinese diabetic patients and their offspring.


METHODS
The study included 59 volunteers from 20 diabetic families. Each participant completed a 75-g oral glucose tolerance test (OGTT) and a euglycaemic insulin clamp. We tested the correlation of surrogate measures of insulin sensitivity with M-values and M/I ratios (the amount of glucose infused during 90-120 min of the clamp was defined as M, and the mean values of plasma insulin during 90-120 min as I) from the euglycaemic insulin clamp. These measures included fasting insulin (FPI), insulin at 120 min of OGTT, insulin area under the curve of OGTT, fasting glucose-to-insulin ratio, homeostasis model assessment for insulin sensitivity (HOMA-IR and HOMA %S) and the Matsuda-DeFronzo index from OGTT.


RESULTS
The Matsuda-DeFronzo index closely correlated to M-value and M/I in 21 diabetic, 38 non-diabetic individuals and the 59 participants overall (with M-value, r = 0.68, 0.84 and 0.84; with M/I, r = 0.71, 0.72 and 0.75, respectively, all P < 0.001). Without OGTT, HOMA %S was a good surrogate index for diabetic (correlated to M-value and M/I, r = 0.71 and 0.68, P = 0.001) and for non-diabetic subjects (to M-value, r = 0.73; to M/I, r = 0.55, both P < 0.001). FPI was as good as HOMA %S and Matsuda-DeFronzo index.


CONCLUSIONS
The Matsuda-DeFronzo index, HOMA %S and FPI are good surrogate estimates of insulin sensitivity in Chinese diabetic subjects and their offspring.
Kuo
C S
CS
Section of Endocrinology and Metabolism, Department of Medicine, Tapei Veterans Hospital, Tapei, Taiwan.
Hwu
C M
CM
Kwok
C F
CF
Hsiao
L C
LC
Weih
M J
MJ
Lee
S H
SH
Lee
Y S
YS
Ho
L T
LT
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000208:ethnology / Q000235:genetics; D005215:Fasting / Q000097:blood; D005260:Female; D015309:Glucose Clamp Technique / Q000379:methods / Q000592:standards; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012680:Sensitivity and Specificity
D015415:Biomarkers; D007004:Hypoglycemic Agents; D007328:Insulin