Hypertension: a microvascular and tubulointerstitial disease.
The vast majority of patients with essential hypertension have structural changes in their kidneys consisting of preglomerular vascular disease ('arteriolosclerosis') and tubulointerstitial injury. Most authorities have assumed that these structural changes occur secondary to hypertensive renal injury. However, Goldblatt proposed that primary renal microvascular disease might be the cause of some forms of hypertension. In this paper we present recent studies from our group that support a role for both preglomerular vascular disease as well as the tubulointerstitial inflammatory response in mediating salt-sensitivity. We propose that subtle acquired renal injury may underlie the etiology of some forms of salt-sensitive hypertension.
Johnson
Richard J
RJ
Division of Nephrology, Department of Medicine, Baylor College of Medicine, SM-1273, 6550 Fannin Street, Houston, Texas 77030, USA. rjohnson@bcm.tmc.edu
Rodríguez-Iturbe
Bernardo
B
Schreiner
George F
GF
Herrera-Acosta
Jaime
J
D000818:Animals; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007511:Ischemia / Q000150:complications; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications*; D009399:Nephrons / Q000473:pathology; D012965:Sodium Chloride / Q000494:pharmacology; D014652:Vascular Diseases / Q000150:complications*
D012965:Sodium Chloride