Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.
OBJECTIVE
To compare the efficacy and tolerability of bisoprolol, enalapril and nifedipine retard in the treatment of mild to moderate essential hypertension.


METHODS
This is a randomized, double-blind, multicenter clinical trial. 331 patients with mild to moderate hypertension in the army troop were randomly allocated to receive domestic bisoprolol (  n  =110,5 mg/d),enalapril (  n  =111,10 mg/d) and nifedipine retard (  n  =110,20 mg/day). Total duration of active drug treatment was 4 weeks.


RESULTS
The total efficacy rates of domestic bisoprolol, enalapril and nifedipine retard were 80.0%, 82.0% and 81.8% respectively  P > 0.05  . The incidences of adverse events were 4.5%, 8.1% and 19.1% (P < 0.01 ) in patients of bisoloprol, enalapril and nifedipine retard groups respectively. The adverse effects were mild in all the three groups.


CONCLUSIONS
Domestic bisoprolol, enalapril and nifedipine retard are effective and well-tolerated in patients with mild to moderate essential hypertension. The occurrence of adverse effects were least in the bisoprolol group and most in the nifedipine retard group.
Department of Cardiology, The General Hospital of PLA, Beijing 100853, China.
Guoshu
G
Liu
Mingfeng
M
Li
Xiangyun
X
Shi
Et Al
D017298:Bisoprolol; D001794:Blood Pressure / Q000187:drug effects; D002681:China; D004311:Double-Blind Method; D004656:Enalapril; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009543:Nifedipine
D004656:Enalapril; D009543:Nifedipine; D017298:Bisoprolol