Respiratory depression in the acute management of seizures.
The incidence of respiratory depression following treatment of prolonged seizures with benzodiazepines is variable in the literature. We retrospectively reviewed the charts of children treated for prolonged seizure over a one year period. Of the 56 seizures treated, 30 received lorazepam, 19 diazepam, and seven both drugs. Twenty two episodes (39%) of prolonged seizure were treated with multiple doses of benzodiazepines. In eight events (14%), there was documented respiratory depression following the administration of one or more doses of benzodiazepine; in six of these, multiple doses were given. The doses used were often at the low end or less than the recommended dose for treatment of status epilepticus. These data support suggestions that multiple doses of benzodiazepines increase the risk of respiratory depression.
Department of Pediatrics, Division of Pediatric Neurology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada. wastewar@is.dal.ca
W A
WA
Stewart
R
R
Harrison
J M
JM
Dooley
D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003975:Diazepam / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D008140:Lorazepam / Q000009:adverse effects*; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D012307:Risk Factors; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D008140:Lorazepam; D003975:Diazepam