Psychophysiological index during auditory selective attention correlates with visual continuous performance test sensitivity in normal adults.
The continuous performance test (CPT) provides a reliable index of cognitive function, but it is still unclear what aspects of processing this test measures. This study aimed to investigate the contribution of different aspects of cognitive function to the performance on degraded stimulus CPT (DSCPT), which requires a higher level of mental effort than the conventional CPT. Event-related potential (ERP) components, MMN, N2b, and early and late Nds were measured at 16 electrode sites in 19 right-handed normal volunteers using an auditory selective attention task. The association between CPT sensitivity ratings (sensitivity A') and amplitudes of each component was examined for each electrode site. The CPT sensitivity A' showed a significant positive correlation with the N2b amplitude in the fronto-central and temporal regions, predominantly in the right hemisphere and specifically to the right ear of stimulation. This finding suggests that the controlled deviance detection process was related to DSCPT performance.
Department of Psychiatry, Harvard Medical School, Brockton VA Medical Center, Department of Psychiatry-116A, 940 Belmont Street Brockton, Boston, MA 02301, USA.
Kiyoto
K
Kasai
Kazuyuki
K
Nakagome
Ken-Ichi
K
Hiramatsu
Masato
M
Fukuda
Makoto
M
Honda
Akira
A
Iwanami
D000161:Acoustic Stimulation / Q000379:methods / Q000523:psychology*; D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D011603:Psychophysiology; D018709:Statistics, Nonparametric