Molecular imprinted polymer coated QCM for the detection of nandrolone.
An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively screen for nandrolone in the liquid phase. A highly specific covalently imprinted polymer (MIP) was spin coated onto one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the nandrolone was observed as a frequency shift in the QCM for concentrations up to 0.2 ppm with the sensor binding shown to favour nandrolone over analogous compounds.
Department of Chemistry and Physics, The Nottingham Trent University, Clifton Lane, Nottingham, UK NG11 8NS.
C J
CJ
Percival
S
S
Stanley
A
A
Braithwaite
M I
MI
Newton
G
G
McHale
D045930:Anabolic Agents / Q000652:urine*; D004563:Electrochemistry; D004586:Electrophoresis / Q000295:instrumentation; D004845:Epitestosterone / Q000652:urine; D017022:Flow Injection Analysis; D006801:Humans; D009277:Nandrolone / Q000652:urine*; D011108:Polymers; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*; D013739:Testosterone / Q000652:urine
D045930:Anabolic Agents; D011108:Polymers; D013739:Testosterone; D004845:Epitestosterone; D009277:Nandrolone