14-3-3s are DNA-replication proteins.
14-3-3 proteins are conserved multifunctional molecules, involved in many biological processes. Several 14-3-3 isoforms were recently shown to be cruciform DNA-binding proteins, which is a new activity ascribed to the 14-3-3 family. As cruciform-binding proteins, 14-3-3 proteins are putatively involved in the regulation of DNA replication. Inverted repeat sequences that are able to extrude into cruciform structures are a common feature of replication origins in both prokaryotes and eukaryotes. The involvement of cruciform structures in the initiation of DNA replication has been demonstrated. A leading model of 14-3-3 function proposes that they facilitate critical protein-protein interactions, thus serving as a central component of a wide variety of cellular processes.
McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. maria.zannis@mcgill.ca
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D048948:14-3-3 Proteins; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D004261:DNA Replication; D006801:Humans; D018741:Replication Origin; D015398:Signal Transduction / Q000502:physiology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D048948:14-3-3 Proteins; D014446:Tyrosine 3-Monooxygenase