Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro.
The effects of lamivudine (3TC) on in vitro infection of peripheral blood mononuclear cells (PBMC) from healthy donors with human T-cell lymphotropic virus type 1 (HTLV-1) were investigated. Direct measures of viral replication (viral DNA, RNA, and protein) all gave similar, very high 50% inhibitory concentrations in comparison with those previously reported for zidovudine. Nevertheless, 3TC inhibited HTLV-1-driven long-term growth of infected PBMC in vitro at concentrations (6.25 micro M) which had poor or no direct antiviral effects, suggesting that another mechanism may be playing a role.
Department of Microbiological, Genetic and Molecular Science, University of Messina, Messina, Italy.
Emanuela
E
Balestrieri
Giancarlo
G
Forte
Claudia
C
Matteucci
Antonio
A
Mastino
Beatrice
B
Macchi
D019380:Anti-HIV Agents / Q000494:pharmacology*; D018920:Coculture Techniques; D004279:DNA, Viral / Q000096:biosynthesis / Q000235:genetics; D006800:Deltaretrovirus Infections / Q000517:prevention & control / Q000635:transmission* / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects*; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology*; D009000:Monocytes / Q000821:virology*; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D004279:DNA, Viral; D019259:Lamivudine