Electroretinographic changes in the inner retinal layers of the retained eyes of patients with sporadic unilateral retinoblastoma.
OBJECTIVE
Examination of retinal function as measured by flash electroretinogram (ERG) including oscillatory potentials (OPs) and pattern electroretinogram (PERG) in a series of patients with unilateral sporadic retinoblastoma.


METHODS
Studies were undertaken in the retained eye (without clinical evidence of retinoblastoma) of 13 patients with sporadic unilateral retinoblastoma and in 13 healthy controls.


METHODS
Standard flash ERG including scotopic OPs and PERG recordings were performed in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) standards.


RESULTS
Statistically significant differences between the studied and the control groups were observed with flash ERG (OP1 amplitude increase, p < 0.003; photopic flicker amplitude increase, p < 0.05) and PERG (P50 latency increase, p < 0.008).


CONCLUSIONS
Inner retinal layer dysfunction may be a characteristic feature of individuals with unilateral sporadic retinoblastoma.
Clinic of Ophthalmology, Pomeranian Academy of Medicine, Szczecin, Poland. lubinski@pro.onet.pl
Wojciech
W
Lubiński
Stanisław
S
Zajaczek
Zbigniew
Z
Sych
Krzysztof
K
Penkala
Olgierd
O
Palacz
Jan
J
Lubiński
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004596:Electroretinography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010364:Pattern Recognition, Visual; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology; D012160:Retina / Q000503:physiopathology*; D019572:Retinal Neoplasms / Q000503:physiopathology*; D012175:Retinoblastoma / Q000503:physiopathology*