Regulatory T cells in transplantation.
There has recently been an explosion of renewed interest in regulatory T cells, particularly those within the CD4(+)CD25(+) population. It is becoming increasingly apparent that these cells exist not only as naturally occurring cells that may contribute to the maintenance of self-tolerance, but they also have the potential to prevent rejection of allografts in experimental models. Such cells have now been identified in humans as well as in rodents.
Karim
Mahzuz
M
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, UK. mkarim@doctors.org.uk
Bushell
Andrew R
AR
Wood
Kathryn J
KJ
D000818:Animals; D016207:Cytokines / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D007376:Interleukin-2 / Q000502:physiology; D007519:Isoantigens / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*; D014181:Transplantation Immunology
D016207:Cytokines; D007376:Interleukin-2; D007519:Isoantigens; D015375:Receptors, Interleukin-2; D017493:Leukocyte Common Antigens