"Have you seen this?" peliosis hepatis.
Peliosis hepatis, characterized by the presence of blood-filled spaces within hepatic parenchyma, developed in C57Bl mice implanted subcutaneously with melanoma cells 23 days previously. The peliosis was associated with dilated hepatic sinusoids that were lined by prominent, proliferating endothelial cells. The development of peliosis hepatis was completely abrogated when melanoma growth was inhibited by administration of dexamethasone. These features support the concept that peliosis hepatis can be induced by a circulating tumor-derived endothelial growth factor such as vascular endothelial growth factor.
MRC Toxicology Unit, University of Leicester, United Kingdom.
Richard
R
Edwards
Tina
T
Colombo
Peter
P
Greaves
D000818:Animals; D005260:Female; D008099:Liver / Q000473:pathology; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010382:Peliosis Hepatis / Q000473:pathology*