Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.
Subtilisin/kexin isozyme-1 (SKI-1), otherwise known as Site-1 protease (S1P), is a Golgi proteinase mediating the proteolytic activation of the precursor to sterol-regulated element-binding proteins (SREBPs) 1 and 2, two transcriptional factors that regulate expression of a variety of genes involved in cholesterol and lipid metabolism. Using PCR and RFLP analysis on a panel of genomic DNA from a mouse intersubspecific back-cross, we have mapped the SK1-/S1P gene (locus symbol: Mbtps1) to the distal part of mouse chromosome 8, in a region that exhibits synteny homology to the human chromosome 16q24 region where its orthologue had been previously mapped.
Tadros
Haidy
H
Diseases of Aging Program, Ottawa Health Research Institute, University of Ottawa, 725 Parkdale Avenue, Ottawa, Ont., Canada K1Y 4K9.
Seidah
Nabil G
NG
Chrétien
Michel
M
Mbikay
Majambu
M
D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D051379:Mice; D043484:Proprotein Convertases; D012697:Serine Endopeptidases / Q000235:genetics*; D026801:Synteny
D043484:Proprotein Convertases; D012697:Serine Endopeptidases; C115575:membrane-bound transcription factor peptidase, site 1