Effects of rinbacin extract on rat kidney.
The aqueous leaf extract of rinbacin was tested for toxic effects on prepubertal rat kidneys following chronic administration. Two doses of rinbacin extract (26.25 g/l and 52.50 g/l) were administered in the rats' drinking water for 13 weeks, and various toxicologic indices tested. Histological study of the kidneys was also carried out at the expiration of the test period. Rinbacin at both dose sizes significantly (p<0.05) increased the absolute and relative kidney weights. Also the serum HCO3- level was significantly (p<0.05) increased, while the serum K+ level was decreased significantly at both dose levels. Only the high dose significantly (p<0.05) increased the serum urea level of the rats. Histological study showed that rinbacin at both dose sizes caused renal pathologic changes, which included necrosis and cellular infiltration of glomeruli and epithelia of the tubules. The effects were less marked in the low dose than the high dose group. Chronic administration of rinbacin extract induces nephrotoxicity in young rats.
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University Nnewi, Anambra State, Nigeria. connice@infoweb.abs.net
Onyenmechi Johnson
OJ
Afonne
Orish Ebere
OE
Orisakwe
Chudi Emma
CE
Dioka
Ejeatuluchukwu
E
Obi
Tobias
T
Ezejiofor
Lasbery
L
Asomugha
Ukoha
U
Ukoha
D000818:Animals; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009549:Nigeria; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000633:toxicity*; D051381:Rats
D010936:Plant Extracts