Multifocal ERG in multiple evanescent white dot syndrome.
OBJECTIVE
To investigate the electrophysiological findings of a multifocal ERG in multiple evanescent white dot syndrome (MEWDS).


METHODS
Multifocal electroretinograms (mf-ERG) were recorded from four patients with MEWDS. The stimulus array consisted of 61 hexagons and was presented according to a binary m-sequence. We analyzed the N1- and P1-wave amplitudes as well as P1 latencies of the first-order kernels. Local responses and concentric ring averaged responses were compared to 20 age-matched normal subjects. All patients underwent fluorescein angiography and indocyanine green angiography.


RESULTS
In two patients, first-order kernel of N1- and P1-wave amplitudes showed supernormal results at the very beginning (day 1 to day 7) of the disease. By 2 weeks later, N1- and P1-wave amplitudes had decreased to either normal or subnormal values. The two patients who presented 2 weeks after the onset of clinical signs showed subnormal or decreased amplitudes. The P1 implicit times were within normal limits in all patients.


CONCLUSIONS
Our mf-ERG findings show different results during the course of the disease. First-order kernel amplitudes seem to reflect early disturbances of the photoreceptors in MEWDS and are therefore useful in detecting early stages and following up the disease.
Feigl
Beatrix
B
Department of Ophthalmology, Karl-Franzens University, Auenbruggerplatz 4, 8036 Graz, Austria. b.feigi@qut.edu.au
Haas
Anton
A
El-Shabrawi
Yosuf
Y
D000328:Adult; D004396:Coloring Agents; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D012160:Retina / Q000502:physiology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology*; D013577:Syndrome
D004396:Coloring Agents; D007208:Indocyanine Green