[Heat shock protein 70 expression following transient ischemia in the gerbil].
OBJECTIVE
To study the expression of heat shock protein 70(HSP70) following transient ischemia in the gerbil.


METHODS
Immunohistochemistry(IHC) was used to determine the expression of the HSP70 protein in the forebrain during different periods after post-ischemic reperfusion in the gerbil, and the neuronal damage was examined with microscope.


RESULTS
The HSP70 protein was only expressed at the 1st day of reperfusion(P < 0.01); and most of the neurons showed damage on the 7th day of reperfusion; heat-preconditioning could increase the expression of HSP70 protein(P < 0.01) and decrease the neuronal damage(P < 0.001) after 6 min of ischemia.


CONCLUSIONS
Heat-preconditioning could protect neural cells from damage by increasing the expression of the HSP70 protein.
Institute of Neurology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
W P
WP
Gu
Q D
QD
Yang
G J
GJ
Xie
D000818:Animals; D001921:Brain / Q000473:pathology; D005849:Gerbillinae; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D018869:Heat-Shock Response / Q000502:physiology*; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000473:pathology; D051381:Rats
D018840:HSP70 Heat-Shock Proteins