RNA silencing: small RNAs as ubiquitous regulators of gene expression.
'RNA silencing' is the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by RNA. Initially identified as an immune system that is targeted against transposons and viruses, RNA silencing is emerging as a fundamental regulatory process that is likely to affect many layers of endogenous gene expression in most, if not all, eukaryotes.
The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK. Olivier.voinnet@ibmp-ulp.u-strasbg.fr
Olivier
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Voinnet
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D020868:Gene Silencing; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity; D014158:Transcription, Genetic / Q000235:genetics*
D035683:MicroRNAs; D034741:RNA, Small Interfering