Positron emission tomography: measurement of the activity of second messenger systems.
Phosphoinositide turnover is closely connected to modulation of synaptic function and is part of an important second messenger-producing system. New radioligands for imaging second messenger systems by positron emission tomography have been developed: carbon-11-labeled 1,2-diacylglycerols. The theoretical background of second messenger imaging is described in detail and the relation between the biologically active compounds and potential tracers for imaging second messenger systems is discussed. We report informative findings on postsynaptic biological responses in the living human brain of healthy normal subjects and with various diseases.
Department of Neurosurgery, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo 602-8566, Kyoto, Japan. imahori@koto.kpu-m.ac.jp
Yoshio
Y
Imahori
Ryou
R
Fujii
Hitoshi
H
Tujino
Minoru
M
Kimura
Katsuyoshi
K
Mineura
D000328:Adult; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D004075:Diglycerides / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D011849:Radioactive Tracers; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D015290:Second Messenger Systems / Q000502:physiology*; D014055:Tomography, Emission-Computed / Q000379:methods* / Q000592:standards
D002250:Carbon Radioisotopes; D004075:Diglycerides; D010716:Phosphatidylinositols; D011849:Radioactive Tracers