Oiling the wheels of the endocytic pathway.
An ever more complete picture of the organization and function of the endocytic pathway is emerging. New mechanisms, and in particular lipid-based mechanisms that couple membrane dynamics and sorting, are being unraveled. But the final picture is still coming into focus as new membrane domains, cell entry pathways and compartments come into view. Of special interest are the recent findings that pathogenic agents, in contrast to scientists, seem to have long discovered how to subvert membrane specialization to their own advantage.
Dept of Genetics and Microbiology, CMU, 1 rue Michel Servet, University of Geneva, CH-1211 Geneva 4, Switzerland. Gisou.vandergoot@medecine.unige.ch
F Gisou
FG
van der Goot
Jean
J
Gruenberg
D000818:Animals; D001427:Bacterial Toxins / Q000493:pharmacokinetics; D002451:Cell Compartmentation; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains; D021381:Protein Transport; D022161:Transport Vesicles
D001427:Bacterial Toxins