Dopaminergic receptors: a new antihypertensive mechanism.
The neutrotransmitter dopamine, precursor of noradrenaline, induces a variety of cardiovascular and renal physiological responses, including an increase in myocardial contractility and cardiac output without changes in heart rate, passive and active vasodilatation, diuresis and natriuresis. These responses result from its interaction with the dopamine receptors D1, D2, D3, D4 and D5. In addition, recent findings suggest the existence of D6 and D7 receptors. In some types of hypertension dopamine is known to influence the control of arterial pressure by influencing the central and peripheral nervous system and target organs such as the kidneys and adrenal glands. Since dopamine and its derivatives have been shown to have antihypertensive effects, it is important to review the physiological and pharmacological aspects of dopamine and its receptors, and the clinical uses that they could have in the therapy of arterial hypertension.
Clinical Pharmacology Unit, Vargas School of Medicine, Universidad Central de Venezuela, Caracas, Venezuela. velascom@cantu.net
Manuel
M
Velasco
Freddy
F
Contreras
Gloria A
GA
Cabezas
Alejandra
A
Bolívar
Christian
C
Fouillioux
Rafael
R
Hernández
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D018491:Dopamine Agonists / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000737:chemistry / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D011954:Receptors, Dopamine / Q000032:analysis / Q000502:physiology*; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D000959:Antihypertensive Agents; D018491:Dopamine Agonists; D011954:Receptors, Dopamine; D017923:Sodium-Hydrogen Exchangers; D011493:Protein Kinase C; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine