Cardiovascular effects of orally administered HNS-32, an originally synthesized azulene-1-carboxamidine derivative, assessed in the in vivo rat model.
HNS-32, an azulene-1-carboxamidine derivative, is an originally synthesized antiarrhythmic compound. Its cardiovascular effects after oral administration (1-10 mg/kg) were assessed using the pentobarbital-anesthetized in vivo rat model in comparison with those of verapamil (3 mg/kg, p.o.). Verapamil decreased the heart rate and mean blood pressure and prolonged the PR interval without changing the QRS width (n = 6). Similar results were observed for HNS-32 except that the QRS width was prolonged by the highest dose and the effects occurred slowly and lasted longer. These results suggest that HNS-32 is an orally active slowly-acting calcium plus sodium channel blocker.
Department of Pharmacology, Yamanashi Medical University, Nakakoma-gun, Japan.
Masaki
M
Saitoh
Atsushi
A
Sugiyama
Tomoo
T
Nakazawa
Keitaro
K
Hashimoto
D000284:Administration, Oral; D000818:Animals; D052176:Azulenes; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects*; D003508:Cycloheptanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D026941:Sodium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology
D052176:Azulenes; D002121:Calcium Channel Blockers; D003508:Cycloheptanes; D011725:Pyridines; D026941:Sodium Channel Blockers; C108264:HNS 32; C005525:azulene