[Correlation of histological classifications of gastric carcinomas with location and prognosis].
OBJECTIVE
To evaluate the prognostic impact of different histological classifications of gastric adenocarcinoma.


METHODS
Between 1993-2000, 94 patients with gastric adenocarcinoma were studied. Tumors were classified according to TNM staging, WHO, Lauren and Goseki classifications. Twenty five patients (27%) had a proximal tumor and 69 (73%) a distal tumor. Intestinal type according to Lauren were more often observed among the proximal carcinomas (19/25) than in distal ones (32/69) (P=0.01). According to Goseki, lymph node metastasis were less frequently found in group III (5/13) than in other groups (64/81) (P=0.033). The mean follow-up was 23 months. Survical was not influenced by WHO, Lauren, and Goseki classifications. Survival significantly varied according to the different groups of the TNM classification. The proximal location of the tumor was associated with poorer prognosis than distal location (P=0.0373). Number of metastatic lymph nodes, invasion of perineurium, and vascular invasion had significant prognostic value in proximal carcinomas.


CONCLUSIONS
The results of this study suggest that gastric carcinomas should be divided into proximal and distal tumors using the Goseki classification in addition to the Lauren classification because the Goseki classification recognizes tumor groups with different dissemination routes.
Calli Demirkan
Nese
N
Service d'Anatomie Pathologique, CHU du Pamukkale, Denizli, Turquie. nesefahir@hotmail.com
Tunçyürek
Müge
M
Ugur Ertan
Engin
E
Bülent Alkanat
Murat
M
Içöz
Gökhan
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000145:classification* / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate