Transformation of myeloid cells with atypical renewal.
The paper discusses malignant transformation of myeloid precursors that had atypical renewal in vivo. Their in vitro transformation rate disproportionates clinical incidences. Besides composition differences of transforming agents, this is due to quali-quantitative deficiencies of multitask growth factors added to empirical cultures. In combination these anomalies perturb the web of differentiation path, whose robustness minimizes clonal transformation in vivo.
Matioli
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GT
USC Medical School, 2011 Zonal Avenue, Los Angeles, CA, USA.
D001854:Bone Marrow Cells / Q000473:pathology*; D002455:Cell Division; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic; D006801:Humans