Annexin 6 immunoreactivity in select cell populations in the rat brain.
We examined the distribution of annexin 6 (ANX6) in rat brain with immunohistochemistry (IHC). Several neuronal cell populations were intensely labeled with the ANX6 monoclonal antibody (MAb), including layer 5 of neocortex, the lateral septum, the lateral hypothalamic area, the red nucleus, and the Purkinje cell layer in cerebellum. Neuronal immunolabeling was localized to the nucleus and the cytosol. Darkly stained ANX6-immunoreactive glia, with the morphology characteristic of astrocytes, were abundant in the hippocampus, substantia nigra reticulata, and cerebellum. Evidence suggests that ANX6 may function in neuronal and glial calcium-dependent processes.
Terre Haute Center for Medical Education, Indiana University School of Medicine, Terre Haute, Indiana 47809, USA. mmoga@medicine.indstate.edu
Margaret M
MM
Moga
Dan
D
Zhou
D000818:Animals; D017317:Annexin A6 / Q000276:immunology / Q000378:metabolism*; D000911:Antibodies, Monoclonal; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D051381:Rats
D017317:Annexin A6; D000911:Antibodies, Monoclonal