Current knowledge in falciparum malaria-induced acute renal failure.
Plasmodium falciparum is highly prevalent in the tropics. Acute renal failure (ARF) is a common complication in severe falciparum malaria. The disorder is usually oliguric or anuric and hypercatabolic. Acute tubular necrosis (ATN), the principal pathologic lesion in falciparum malaria-induced ARF, is mediated by a complex interaction of mechanical, immunologic, cytokine, humoral, acute phase response, non specific factors, and hemodynamics factors. Parasitized erythrocytes express a central role in all aforementioned pathogenic factors of ARF.
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Somchai
S
Eiam-Ong
D019353:Endemic Diseases; D005260:Female; D006801:Humans; D015994:Incidence; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D016778:Malaria, Falciparum / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate; D013785:Thailand / Q000453:epidemiology; D014329:Tropical Climate