The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies.
Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines.
Nwuba
Roseangela I
RI
Cellular Parasitology Programme, Department of Zoology, University of Ibadan, Ibadan, Nigeria.
Sodeinde
Olugbemiro
O
Anumudu
Chiaka I
CI
Omosun
Yusuf O
YO
Odaibo
Alexander B
AB
Holder
Anthony A
AA
Nwagwu
Mark
M
D000293:Adolescent; D000818:Animals; D019138:Antibodies, Blocking / Q000097:blood; D000913:Antibodies, Protozoan / Q000097:blood*; D017951:Antigen Presentation; D001667:Binding, Competitive; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D017780:Malaria Vaccines / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology / Q000517:prevention & control; D020066:Merozoite Surface Protein 1 / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*
D019138:Antibodies, Blocking; D000913:Antibodies, Protozoan; D017780:Malaria Vaccines; D020066:Merozoite Surface Protein 1