Effect of Ginkgo biloba extract on beta-adrenergic receptors in different rat brain regions.
The effect of oral administration of Ginkgo biloba extract at a dose of 90 mg/kg for 7 consecutive days on rat brain beta-adrenergic receptors in the frontal cortex, hippocampus, striatum and hypothalamus was studied. Ginkgo biloba treatment induced a significant decrease in the density (B(max)) of beta-adrenoreceptors in the frontal cortex and hippocampus. It has been suggested that modulation of the beta-adrenergic system is implicated in the favourable effects of Ginkgo biloba extracts on learning and memory.
Hadjiivanova
Ch I
ChI
Department of Chemistry and Biochemistry, Faculty of Ecology, University of Forestry, 10 Kliment Ohridski Avenue, Sofia 1756, Bulgaria.
Petkov
V V
VV
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D020441:Ginkgo biloba; D007858:Learning / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D010936:Plant Extracts; D011943:Receptors, Adrenergic, beta