[Evaluation of bone density in women after thyroid cancer surgery and treatment with suppressive doses of L-thyroxine].
The aim of this work was to evaluate the degree of bone resorption and incidence of osteoporosis in female postmenopausal patients with differentiated thyroid cancer treated with suppressive doses of thyroxine. During the regular follow-up of women with differentiated thyroid cancer, densitometry of lumbar spine (L2-L4) and femoral head were performed. urine concentration of deoxypyridinoline and calcium-phosphate metabolism were also evaluated. Osteoporosis was diagnosed in 11% of patients, all without hormone replacement therapy (HRT). Mean bone density was significantly higher in patients treated with HRT. A decrease in bone mass was related to the duration of thyroxine therapy. The best results of bone mass density were obtained in patients on HRT and with short duration of thyroxine therapy. Deoxypiridinoline estimation did not exhibit significant differences between groups, however it was useful in the individual evaluation of bone resorption.
Zakładu Medycyny Nuklearnej i Endokrynologii Onkologicznej, Centrum Onkologii-Instytut im. M. Skłodowskiej-Curie, Oddział w Gliwicach.
B
B
Jurecka-Tuleja
R
R
August
A
A
Kukulska
W
W
Bartnikowa
R
R
Deja
E
E
Czernik
D
D
Handkiewicz-Junak
D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced*; D011859:Radiography; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D013974:Thyroxine / Q000009:adverse effects* / Q000627:therapeutic use
D013974:Thyroxine