Is there a "bladder sex"? The relation of different sex hormones and sex hormone receptors in bladder in childhood.
The aim of this study was to review the classical concept of bladder physiology in regard to sex hormone effects and to focus on a new concept. Sex hormones affect bladder functions and the classical concept tries to explain these effects via alpha and beta adrenoreceptors. The effects of hormones had been investigated in this understanding. To obtain a biological response to steroids in target tissues, specific proteins--so-called receptors--are warranted. After the demonstration of the sex hormone receptors in bladder first in adults and in children urge questioning the effects of hormones in this regard. The hypothesis is based on the fact that, if a special receptor is present, the direct (via sex hormone receptors) effect is more likely to occur as an indirect effect (via alpha and beta adrenoreceptors). There is evidence that there is a sex difference and the sex receptors and hormones play an important role in some bladder disorders. Therefore we stress the importance of investigating especially the pediatric patients with bladder problems in regard to sex hormone receptors and hormonal status.
Department of Pediatric Surgery, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey. scelayir@escortnet.com
Sinan
S
Celayir
D002648:Child; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D011987:Receptors, Steroid / Q000502:physiology*; D012737:Sex Factors; D001743:Urinary Bladder / Q000502:physiology*
D012739:Gonadal Steroid Hormones; D011987:Receptors, Steroid