Effect of Ginkgo biloba extract on beta-adrenergic receptors in different rat brain regions.
The effect of oral administration of Ginkgo biloba extract at a dose of 90 mg/kg for 7 consecutive days on rat brain beta-adrenergic receptors in the frontal cortex, hippocampus, striatum and hypothalamus was studied. Ginkgo biloba treatment induced a significant decrease in the density (B(max)) of beta-adrenoreceptors in the frontal cortex and hippocampus. It has been suggested that modulation of the beta-adrenergic system is implicated in the favourable effects of Ginkgo biloba extracts on learning and memory.
Department of Chemistry and Biochemistry, Faculty of Ecology, University of Forestry, 10 Kliment Ohridski Avenue, Sofia 1756, Bulgaria.
Ch I
ChI
Hadjiivanova
V V
VV
Petkov
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D020441:Ginkgo biloba; D007858:Learning / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D010936:Plant Extracts; D011943:Receptors, Adrenergic, beta