The effect on vision of associated treatments in patients taking vigabatrin: carbamazepine versus valproate.
OBJECTIVE
To evaluate the effect on visual function of a concomitant antiepileptic drug (AED) in patients treated with vigabatrin (VGB).


METHODS
Sixty-four consecutive patients with a history of partial seizures currently treated with VGB with either carbamazepine (CBZ) or valproate (VPA) were examined with automated kinetic perimetry, static perimetry, electrooculogram (EOG), and electroretinogram (ERG). An original device based on kinetic perimetry was developed to quantify the area of perception for each isopter.


RESULTS
Fifty-two patients were finally included. The results showed a significant difference in patients treated with VGB-VPA compared with patients treated with VGB-CBZ concerning the mean defect of static perimetry and the peripheral and midperipheral isopter (III 4e and III 1a Goldmann equivalent, respectively) in kinetic perimetry. EOG and ERG results did not differ significantly between the two groups.


CONCLUSIONS
The visual impairment due to visual field constriction was more important in patients treated with VGB and VPA compared with patients treated with VGB and CBZ. The origin of this difference between the two associations could not be related to any particular retinal electrophysiologic abnormality.
Service d'Explorations Fonctionnelles de la Vision, Département de Physiologie EA 2689, and Clinique Neurologique, Hôpital Roger Salengro, Lille, France. carcdt@chru-lille.fr
Carl F
CF
Arndt
Marc
M
Salle
Philippe H
PH
Derambure
Sabine
S
Defoort-Dhellemmes
Jean-Claude
JC
Hache
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004585:Electrooculography; D004596:Electroretinography; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000627:therapeutic use*; D020888:Vigabatrin / Q000627:therapeutic use*; D014785:Vision, Ocular / Q000187:drug effects*; D014794:Visual Fields / Q000187:drug effects
D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid; D020888:Vigabatrin