Soy and its isoflavones: a review of their effects on bone density.
Menopausal hormone decline contributes significantly to the risk of osteoporosis. Therapies for treating osteoporosis, such as hormone replacement therapy (estrogen or combination estrogen-progestins), inhibit bone resorption. Both animal and human studies demonstrate phytoestrogenic soy isoflavones favorably impact bone health. The exact mechanism is still unclear. Additional research is needed to determine if isoflavones are an effective alternative to hormone replacement therapy for the prevention and treatment of osteoporosis. This paper reviews in vitro, animal, and human studies involving isoflavones and bone health.
Southern California University of Health Sciences, 16200 East Amber Valley Drive, Whittier, CA 90609, USA.
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D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007529:Isoflavones / Q000494:pharmacology* / Q000627:therapeutic use; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000517:prevention & control*; D013025:Glycine max
D007529:Isoflavones