Prevalence of inherited thrombophilia in young thrombosis patients from the East Bohemian region.
Venous thromboembolism is a multifactorial disease that is defined by multiple interactions between genetic and environmental components. Inherited thrombophilia may result in a hypercoagulable state that causes an increased tendency to thrombosis. We assessed the prevalence of factor V Leiden, factor II 20210A, antithrombin III, protein C and protein S deficiency, and the presence of antiphospholipid syndrome among 325 thrombosis patients from the East Bohemian region with a first episode of thrombosis under the age of 45 years. The average age of the first thrombotic event was 34 years (age range, 14-45 years). These data are not known yet from this part of the Czech Republic. Factor V Leiden was found in 40%, factor II 20210A in 6%, antithrombin III deficiency in 4%, protein C deficiency in 6%, and protein S deficiency in 11% in this cohort. Lupus anticoagulant was detected in 8% and anticardiolipin antibodies in 6%. Our results confirm the usefulness of thrombophilia work-up in patients with venous thrombosis before the age of 45 years in our region. The diagnosis of inherited thrombophilia is important for further management of these patients.
Dulícuek
P
P
Department of Hematology, University Hospital, Hradec Králové, Czech Republic. dulicpet@fnhk.cz
Malý
J
J
Pesuavová
L
L
Pecka
M
M
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000453:epidemiology; D020152:Antithrombin III Deficiency / Q000150:complications / Q000453:epidemiology; D018153:Czech Republic / Q000453:epidemiology; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D015995:Prevalence; D020151:Protein C Deficiency / Q000150:complications / Q000453:epidemiology; D018455:Protein S Deficiency / Q000150:complications / Q000453:epidemiology; D011516:Prothrombin / Q000235:genetics; D012008:Recurrence; D012307:Risk Factors; D019851:Thrombophilia / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology* / Q000209:etiology
D011516:Prothrombin