The relationship between the thyroid gland and the liver.
Thyroxine and tri-iodothyronine are essential for normal organ growth, development and function. These hormones regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic function; the liver in turn metabolizes the thyroid hormones and regulates their systemic endocrine effects. Thyroid dysfunction may perturb liver function, liver disease modulates thyroid hormone metabolism, and a variety of systemic diseases affect both organs. We highlight the intricate relations between the thyroid gland and the liver in health and disease.
Centre for Hepatology, Department of Medicine, Royal Free Campus, Royal Free and University College Medical School, London, UK. r.malik@rfc.ucl.ac.uk
R
R
Malik
H
H
Hodgson
D002908:Chronic Disease; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology*; D008107:Liver Diseases / Q000150:complications / Q000378:metabolism*; D015398:Signal Transduction; D013959:Thyroid Diseases / Q000150:complications / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism
D013963:Thyroid Hormones