Silicone granuloma of the facial tissues: a report of seven cases.
The liquid form of silicone, called dimethicone (dimethylpolysiloxane), has been used extensively in some countries during the past 4 decades for soft tissue augmentation. Although considered biologically inert, this material has been reported as potentially inducing, after tissue injection, a granulomatous inflammatory response of variable severity. Interestingly, a remarkable paucity of reports exists about the development of complications after injections of liquid silicone into the facial tissues, especially considering its high frequency of use. The purpose of this article is to describe the clinical and microscopic features of 7 cases of silicone-induced granulomas that developed after injection of the facial tissues for cosmetic purposes and to discuss the differential diagnosis and management of this condition.
Section of Oral Pathology and Medicine, Dept of Odontology and Stomatology, Azienda Ospedaliera Careggi and University of Florence, Via Morgagni 85, 50234 Florence, Italy. gificarr@tin.it
Giuseppe
G
Ficarra
Adalberto
A
Mosqueda-Taylor
Roman
R
Carlos
D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D008047:Lip Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012841:Simethicone / Q000008:administration & dosage / Q000009:adverse effects*; D015626:Tissue Expansion / Q000009:adverse effects
D012841:Simethicone