The immune development in a child born to a cyclosporin A-treated woman with systemic lupus erythematosus/polymyositis.
The case of a woman affected by an overlap syndrome systemic lupus erythematosus/polymyositis (PM), who presented with active myositis at the start of the pregnancy, is reported. Therapy with cyclosporin, corticosteroids, hydroxychloroquine and high-dose intravenous immunoglobulin induced a progressive remission of clinical and laboratory signs of myositis. At 33 weeks of gestation, after a premature pre-term rupture of membrane, a male child was delivered. Although premature, and small for gestational age, he had a normal growth, and did not show any clinical sign suggestive of immune deficiency. Lymphocyte phenotypical and functional studies, as well as response to vaccination, were also normal.
Division of Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy. cattaneo@master.cci.unibs.it
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Airò
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Antonioli
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Motta
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Faden
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Chirico
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Cattaneo
A
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Tincani
D000293:Adolescent; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007107:Immune System / Q000002:abnormalities* / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007231:Infant, Newborn; D007234:Infant, Premature; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology; D017285:Polymyositis / Q000188:drug therapy / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000276:immunology; D011297:Prenatal Exposure Delayed Effects
D007166:Immunosuppressive Agents; D016572:Cyclosporine