Advanced waldenström's macroglobulinemia: a case of possible cure after systemic chemotherapy, splenic radiation and splenectomy.
A 41-year-old man with advanced Waldenström's macroglobulinemia (WM) associated with the hyperviscosity syndrome, massive splenomegaly and with IgM concentration of 10 g/dl, was treated in January 1984 with plasmapheresis, systemic chemotherapy (M2 protocol) and splenic radiotherapy. He rapidly improved and was discharged 1 month later. Fourteen months later he underwent splenectomy since a mild splenomegaly persisted though the normalization of bone marrow, peripheral blood and electrophoresis with an IgM concentration of 140 mg/dl. However, at this time immunofixation and immunoelectrophoresis showed a small IgM-kappa monoclonal component. The histological and immunohistochemical analysis showed minimal splenic involvement by WM. Two months after splenectomy, immunofixation and immunoelectrophoresis showed no monoclonal component. The spleen was the probable site of minimal residual disease. The patient was treated with monthly chlorambucil and prednisone for 2 years. Subsequently clinical and laboratory tests persisted within normal limits. The last control performed in January 2002 showed that the patient was in good health; bone marrow examination (aspiration, biopsy with immunohistochemical analysis) and immunofixation persisted normally. This interesting case report, with advanced WM, alive, in good health and without signs of disease 18 years from diagnosis, is presented here and the role of splenectomy is debated.
Medical Oncology and Hematology, Civic Hospital, Piacenza, Italy. l.cavanna@ausl.pc.it
Luigi
L
Cavanna
Raffaella
R
Bertè
Antonio
A
Lazzaro
Daniele
D
Vallisa
Carlo Filippo
CF
Moroni
Giuseppe
G
Civardi
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D018365:Neoplasm, Residual / Q000175:diagnosis; D010956:Plasmapheresis; D013156:Splenectomy; D013163:Splenomegaly / Q000532:radiotherapy; D008258:Waldenstrom Macroglobulinemia / Q000628:therapy*
D000970:Antineoplastic Agents