Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy.
OBJECTIVE
The long-term antiseizure effects of local convection-enhanced infusion of the excitotoxin ibotenate were examined in a rat model of temporal lobe epilepsy.


METHODS
A single injection of kainate, an epileptogenic excitatory amino acid, into the left amygdala elicited chronic spontaneous recurrent seizure activity for at least 36 days after the injection. Two weeks after the injection, infusion of ibotenate, a nonepileptogenic excitatory amino acid that is an axon-sparing neuronal cell toxin, into the left amygdala and piriform lobe induced immediate and permanent extinction of electrical and behavioral seizure activity.


CONCLUSIONS
Lesioning of an epileptic focus by convective distribution of ibotenate can produce an enduring suppression of seizure activity, indicating a chemical neurosurgical approach for epilepsy therapy.
Pace
John R
JR
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
Lonser
Russell R
RR
Kirkby
R Duncan
RD
Jeffries
Neal
N
Rogawski
Michael A
MA
Oldfield
Edward H
EH
D000679:Amygdala / Q000187:drug effects* / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000503:physiopathology*; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage* / Q000627:therapeutic use*; D007051:Ibotenic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D007267:Injections; D007608:Kainic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D009498:Neurotoxins / Q000008:administration & dosage* / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D018690:Excitatory Amino Acid Agonists; D009498:Neurotoxins; D007051:Ibotenic Acid; D007608:Kainic Acid