Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins.
An intrauterine origin of childhood acute lymphoblastic leukaemia (ALL) was proven by the identical clonotypic gene rearrangement in the concordant leukaemias of monozygotic twins, arising from a single clonogenic progeny. The monozygotic twins, presented at the age of 22 months with acute megakaryoblastic leukaemia (AML-M7) in one and myelodysplasia transformed to AML-M7 in the other. Leukaemic cells in both twins carried trisomy 21 and additional different clonal evolution changes of del(20q) in the first twin and trisomy 8 in the second. AML-M7 of late infancy with trisomy 21 may be included in the leukaemias of intrauterine origin, possibly a result of genotoxic insult.
Cancer Cytogenetic Laboratory and Centre of Paediatric Haematology/Oncology, Schneider Children's Medical Centre of Israel, Petah Tiqva, Israel. dnaomi@clalit.org.il
Batia
B
Stark
Marta
M
Jeison
Claude
C
Preudhomme
Pierre
P
Fenaux
Shifra
S
Ash
Yifat
Y
Korek
Jerry
J
Stein
Rina
R
Zaizov
Issac
I
Yaniv
D020732:Cytogenetic Analysis; D018450:Disease Progression; D004314:Down Syndrome / Q000196:embryology* / Q000235:genetics; D005260:Female; D005330:Fetofetal Transfusion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000196:embryology* / Q000235:genetics; D011247:Pregnancy; D014430:Twins, Monozygotic