Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation.
Our aim was to investigate the effect of motilin on postprandial proximal gastric motor and sensory function in healthy volunteers. Ten fasted, healthy volunteers were infused intravenously with synthetic motilin or placebo over 90 min. A liquid meal (200 ml) was ingested within 2 min at the start of the infusion. Proximal gastric volume was measured with a barostat device. Abdominal symptoms were scored by visual analog scales. Plasma motilin concentrations were measured using RIA. Endogenous motilin levels were not affected by meal ingestion. After meal intake, gastric relaxation was similar for motilin and placebo. After postprandial relaxation, motilin resulted in a faster return of gastric volume to baseline (P = 0.007). Motilin significantly increased postprandial feelings of nausea (P = 0.03) and tended to increase abdominal pain and abdominal tension. In conclusion, after normal postprandial gastric relaxation, motilin accelerated the return of gastric volume to baseline. In addition, motilin increased postprandial feelings of nausea.
Centre for Human Drug Research, Leiden, The Netherlands.
I M C
IM
Kamerling
A D
AD
van Haarst
J
J
Burggraaf
M
M
de Kam
I
I
Biemond
R
R
Jones
A F
AF
Cohen
A A M
AA
Masclee
D015746:Abdominal Pain / Q000139:chemically induced; D000328:Adult; D004435:Eating; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D009325:Nausea / Q000139:chemically induced; D012677:Sensation / Q000187:drug effects*; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
D009037:Motilin