Increase in oxidized proteins in Theileria sergenti-infected erythrocyte membrane.
As a part of the elucidation of the pathogenesis of anemia in Theileria sergenti infection, oxidized-erythrocyte membrane proteins (OEMPs) collected from T. sergenti-infected calves were examined. The amount of OEMPs were seen to increase with the progress of the anemia and showed a maximum value around the crisis period of the infection. The increase of OEMPs coincided with band Nos. 1, 2, 2.1, 3, 4.1, 5, 6, and 7. The majority of them was located at the Triton X-100 un-extractive phase, and was confirmed as cytoskeletal proteins. This evidence indicates the enhancement of erythrocytic oxidation, and suggests that it might be one of the aggravating factors of anemia in T. sergenti infection.
Hokkaido Research Station, National Institute of Animal Health, Sapporo, Hokkaido 062-0045, Japan.
Yukio
Y
Yagi
Prasobpom
P
Thongnoon
Hiroki
H
Shiono
Yukio
Y
Chikayama
D000740:Anemia / Q000097:blood / Q000469:parasitology / Q000662:veterinary; D000818:Animals; D002417:Cattle; D004910:Erythrocyte Membrane / Q000378:metabolism* / Q000469:parasitology*; D008565:Membrane Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D016794:Theileria / Q000502:physiology*; D013801:Theileriasis / Q000097:blood* / Q000469:parasitology; D013997:Time Factors
D008565:Membrane Proteins