Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope.
GM(1)- and GD(1a)-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD(1a)-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD(1a)-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.
Nachamkin
Irving
I
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283, USA. nachamki@mail.med.upenn.edu
Liu
Jirong
J
Li
Ming
M
Ung
Huong
H
Moran
Anthony P
AP
Prendergast
Martina M
MM
Sheikh
Kazim
K
D000942:Antigens, Bacterial / Q000235:genetics; D001483:Base Sequence; D016123:Campylobacter jejuni / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D004269:DNA, Bacterial / Q000235:genetics; D000939:Epitopes / Q000235:genetics; D005677:G(M1) Ganglioside / Q000235:genetics / Q000276:immunology; D005732:Gangliosides / Q000235:genetics / Q000276:immunology*; D015870:Gene Expression; D005798:Genes, Bacterial; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D018716:Molecular Mimicry; D012307:Risk Factors; D014774:Virulence / Q000235:genetics / Q000276:immunology
D000942:Antigens, Bacterial; D004269:DNA, Bacterial; D000939:Epitopes; D005732:Gangliosides; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides; C021298:ganglioside, GD1a; D005677:G(M1) Ganglioside