[Effects of urapidil on cardiovascular response to tracheal intubation and incision during fentanyl co-induction].
To study the effects of urapidil (URA) on cardiovascular response to tracheal intubation and incision during fentanyl co-induction, forty-two patients (ASA I-II) were randomly divided into four groups: Group F1(n = 10), fentanyl 5 micrograms.kg-1 was given by venous injection; Group F2(n = 10), fentanyl 10 micrograms.kg-1; Group U1(n = 10), URA 0.25 mg.kg-1 plus fentanyl 5 micrograms.kg-1; Group U2(n = 12), URA 0.5 mg.kg-1 plus fentanyl 5 micrograms.kg-1. After tracheal intubation, mean arterial pressure (MAP), diastolic pressure (DP) in Group F1 and systolic pressure (SP) in Group U1 were increased more significantly than those in Group U2(P < 0.05). After incision, the values of SP, MAP, DP and rate-pressure product (RPP) in Group F1 were higher apparently than those in Group U2(P < 0.05); at the 5th minute, SP, MAP, heart rate (HR) and RPP in Group F1 were in higher than those in Group F2 (P < 0.05), and SP, MAP in Group U2 were lower than those in Group U1(P < 0.05). It is suggested that the cardiovascular response to tracheal intubation and incision may be effectively inhibited in combination URA with fentanyl, and the dosage of fentanyl might reduce.
Department of Anesthesiology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
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Yang
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Cai
D018686:Anesthetics, Intravenous; D001649:Bile Duct Diseases / Q000503:physiopathology / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects*; D005283:Fentanyl; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D010879:Piperazines / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D010879:Piperazines; D014665:Vasodilator Agents; C015568:urapidil; D005283:Fentanyl