Design of therapeutic chelating agents.
The successful design of orally active non-toxic selective metal chelators is a much sought-after goal. In order to identify an ideal chelator for clinical use, a range of specifications must be considered, such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. In this overview the comparative properties of ligands capable of endowing complexes with such properties will be discussed.
Hider
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RC
Department of Pharmacy, King's College London, London SE1 9NN, UK. robert.hider@kcl.ac.uk
D001682:Biological Availability; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D008024:Ligands; D008970:Molecular Weight; D013816:Thermodynamics; D014018:Tissue Distribution
D002614:Chelating Agents; D007502:Iron Chelating Agents; D008024:Ligands