[Autoantibodies and anti-factor VIII and Chlamydia pneumoniae infection].
We report the case of a 64-year-old man without hemorrhagic history experiencing epistaxis. The standard hemostasis assessment including prothrombin index, activated partial thromboplastin time (APTT) and platelet count found an isolated abnormal APTT (105 sec vs 33 sec). Therefore, coagulation factors were explored. An acquired factor VIII deficiency (5%) with anti-FVIII antibody (4.5 Bethesda unit.mL-1) was recognised. This anti-FVIII antibody was related to a Chlamydia pneumoniae pulmonary infection. Treatment consisted of: i) Four successive anterior packing and activated factor VII infusion (Novoseven); ii) steroids injection and bi-antibiotherapy. The time course of the epistaxis was favourable under treatment.
Département d'anesthésie-réanimation chirurgicale II, hôpital Claude-Huriez, rue Michel Polonowski, CHRU de Lille, 59037 Lille, France.
L
L
Da Mata
M
M
Costecalde
J
J
François
L
L
Carpentier
E
E
Wiel
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology*; D001780:Blood Coagulation Tests; D002690:Chlamydia Infections / Q000276:immunology*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D004844:Epistaxis / Q000150:complications / Q000188:drug therapy; D005169:Factor VIII / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D013256:Steroids
D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D013256:Steroids; D005169:Factor VIII