Vasopressin induces emesis in Suncus murinus.
This paper reports that vasopressin is emetogenic in the house musk shrew Suncus murinus. Either intravenous or intracerebroventricular administration of vasopressin caused vomiting within a few minutes. The ED50 of intravenous vasopressin was as high as 4.67 microg/kg, whereas intracerebroventricularly injected vasopressin was effective at a low dose of 20 ng/brain. The emetogenic target of vasopressin may therefore be present in the central nervous system. We propose the Suncus as a useful animal for investigation of vasopressin-mediated emesis, including motion sickness.
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan. ikegaya@tk.airnet.ne.jp
Yuji
Y
Ikegaya
Norio
N
Matsuki
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D012788:Shrews / Q000502:physiology*; D014667:Vasopressins / Q000097:blood / Q000494:pharmacology*; D014839:Vomiting / Q000097:blood / Q000139:chemically induced*
D014667:Vasopressins