Salivary duct carcinoma: cytokeratin 14 as a marker of in-situ intraductal growth.
OBJECTIVE
The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth.


RESULTS
We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and alpha-smooth muscle actin) in five cases of salivary duct carcinoma. This panel is currently used for identification of different components of salivary gland tumours in our laboratory. All tumour cells were positive for cytokeratins 7 and 8. Few neoplastic structures expressed cytokeratin 14 in cells surrounding tumour islands.


CONCLUSIONS
The finding of cytokeratin 14 was important to confirm the in-situ intraductal growth, which probably characterizes this low-grade neoplasm.
de Araújo
V C
VC
Oral Pathology Department, School of Dentistry, University of São Paulo, Universidade Estadual de Pernambuco, and Cancer Hospital AC Camargo, São Paulo, Brazil.
Kowalski
L P
LP
Soares
F
F
de Araújo
N S
NS
Loducca
S V L
SV
Sobral
A P V
AP
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000378:metabolism* / Q000473:pathology*
D014408:Biomarkers, Tumor; D007633:Keratins