New approaches in the management of rectal carcinoma result in reduced local recurrence rate and improved survival.
OBJECTIVE
To find out whether total mesorectal excision (TME) technique alone or combined with preoperative radiotherapy reduces local recurrence rate and improves survival.


METHODS
Partly retrospective (the first period), partly prospective (the second period) study.


METHODS
University hospital, Helsinki, Finland.


METHODS
144 patients between 1980 and 1990 and 61 patients between 1991 and 1997 with rectal cancer, who underwent major curative surgery.


METHODS
A conventional surgical technique was used during the first period and TME alone or combined with preoperative radiotherapy when appropriate during the second period.


METHODS
Postoperative morbidity and mortality, local recurrence rate, and 5-year survival.


RESULTS
After anterior resection 4/76 of the patients (5%) during the first period and 8/43 (19%) during the second period developed anastomotic leaks. Operative 30-day mortality was 1% (n = 1) and 0, respectively. Actuarial local recurrence rate was 17% in the first period and 9% in the second period. Actuarial crude 5-year survival improved from 55% to 78% and cancer-specific survival from 67% to 86% between the two study periods.


CONCLUSIONS
Despite an increased number of anastomotic complications TME is safe. Refinement of the surgical technique together with preoperative radiotherapy yields lower local recurrence rates and an improved survival compared with conventional surgery alone.
Fourth Department of Surgery, Helsinki University Central Hospital, Finland.
Jaana H
JH
Vironen
Leena
L
Halme
Peter
P
Sainio
Lauri E J
LE
Kyllönen
Tom
T
Scheinin
Antero I
AI
Husa
Ilmo H
IH
Kellokumpu
D000206:Actuarial Analysis; D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D011183:Postoperative Complications / Q000453:epidemiology; D011300:Preoperative Care; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors