Recombinant human osteogenic protein-1 (bone morphogenetic protein-7) as an osteoinductive agent in spinal fusion.
METHODS
The data related to spinal applications of osteogenic protein-1 presented at national meetings or published in peer-reviewed literature are reviewed.


OBJECTIVE
To review the available data related to the use of osteogenic protein-1 for spinal arthrodesis. REVIEW OF BACKGROUND DATA: Osteogenic protein-1 (bone morphogenetic protein-7) is a member of the bone morphogenetic protein family and has shown strong osteoinductivity in vivo.


METHODS
The background related to osteogenic protein-1 for spinal applications and the known studies presented at national meetings or published in the peer-reviewed literature are reviewed.


RESULTS
Osteogenic protein-1 is able to achieve solid bony fusion of the spine in both the anterior and posterolateral environments in animal studies and has a good safety profile. Early human trials appear to be promising.


CONCLUSIONS
Animal studies support the ability of osteogenic protein-1 to enhance or replace autograft for spinal arthrodesis in both the posterolateral and interbody environment. Human trials ultimately will provide data to clarify the optimal role of osteogenic protein-1 in human spinal surgery.
Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Alexander R
AR
Vaccaro
D Greg
DG
Anderson
Carol A
CA
Toth
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D002986:Clinical Trials as Topic; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D023421:Models, Animal; D010012:Osteogenesis / Q000187:drug effects*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013123:Spinal Fusion / Q000379:methods*; D016212:Transforming Growth Factor beta; D016896:Treatment Outcome
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta