Subincanadines A-C, novel quaternary indole alkaloids from Aspidosperma subincanum.
Three novel quaternary indole alkaloids with an unprecedented 1-azoniatricyclo[4.3.3.0(1,5)]undecane moiety, subincanadines A-C (1-3), as well as two new indole alkaloids with a 1-azabicyclo[5.2.2]undecane moiety, subincanadines D (4) and E (5), and a new indole alkaloid with a 1-azabicyclo[4.3.1]decane moiety, subincanadine F (6), have been isolated from the barks of Aspidosperma subincanum Mart, and the structures of 1-6 and the stereochemistry of 1-3 were elucidated by spectroscopic data and chemical means.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
Jun'ichi
J
Kobayashi
Mitsuhiro
M
Sekiguchi
Sayaka
S
Shimamoto
Hideyuki
H
Shigemori
Haruaki
H
Ishiyama
Ayumi
A
Ohsaki
D030009:Aspidosperma / Q000737:chemistry*; D001938:Brazil; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D026121:Indole Alkaloids; C472460:subincanadine A; C472461:subincanadine B; C472462:subincanadine C