Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (gamma-GTP) activity in non-drinkers.
To understand the significance of elevated serum gamma-GTP levels, factors relevant to the serum gamma-GTP level were studied using data of health check-ups for the employees of a Japanese corporation. The gamma-GTP level was positively correlated with levels of various liver function tests including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Except for them, the gamma-GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index. The correlation between the gamma-GTP level and LDL cholesterol was also observed only when subjects who drank more than 5 times a week were selectively studied. When non-drinkers and opportunity drinkers were selectively studied, 63.6% of subjects whose gamma-GTP level was more than 120 IU/liter showed elevated insulin resistance levels. Multiple factors including insulin resistance may affect serum gamma-GTP activity in clinical subjects.
Yokoyama
Hirokazu
H
Health Center, Keio University, Tokyo, Japan. yokoyama@sc.itc.keio.ac.jp
Hirose
Hiroshi
H
Moriya
Susumu
S
Saito
Ikuo
I
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000437:Alcoholism / Q000201:enzymology; D001219:Aspartate Aminotransferases / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000201:enzymology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000175:diagnosis / Q000201:enzymology; D007333:Insulin Resistance / Q000502:physiology*; D007564:Japan; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood*
D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase