Immunohistochemical confirmation of pulmonary papillary adenocarcinoma metastatic to ovaries.
Metastatic papillary adenocarcinomas of the ovary are rare compared to primary ovarian papillary serous carcinomas. We report a case of pulmonary papillary adenocarcinoma metastatic to the ovary and show how this tumor can be differentiated immunohistochemically from an ovarian primary. Paraffin blocks of the ovarian tumor were analyzed for carcinoembryonic antigen, CA 125, surfactant, E-cadherin, N-cadherin, and vimentin. These markers are useful in differentiating epithelial tumors of lung versus ovarian origin. The papillary tumor showed expression of carcinoembryonic antigen, surfactant, and E-cadherin, but was negative for CA 125, N-cadherin, and vimentin. These findings support a lung carcinoma metastatic to the ovary.
Householder
JeanMarie
J
Department of Obstetrics and Gynecology, The Reading Hospital and Medical Center, West Reading, PA 19612, USA.
Han
Aaron
A
Edelson
Mitchell I
MI
Eager
J Michael
JM
Rosenblum
Norman G
NG
D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000188:drug therapy / Q000556:secondary*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D018394:CA-125 Antigen / Q000032:analysis; D015820:Cadherins / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D011663:Pulmonary Surfactants / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D015820:Cadherins; D002272:Carcinoembryonic Antigen; D009363:Neoplasm Proteins; D011663:Pulmonary Surfactants; D014746:Vimentin