CD4(+) T cell levels are decreased during active CMV infection in kidney transplant recipients.
The numbers of T lymphocytes and T cell subsets (CD2(+), CD3(+), CD4(+), CD8(+)), activated T cells (CD26(+)), B cells (CD19(+)), granulocytes (CD15(+)) and natural killer cells (CD16/56) were monitored by flow cytometry in 79 kidney transplant recipients, 35 of whom had cytomegalovirus infection. The percentages of these cells were correlated with viral load, as determined by cytomegalovirus antigenemia. Development of cytomegaloviral infection coincided with a significant reduction in the percentages of CD4(+) (P < 0.005) and CD3(+) (P < 0.05) cells. Monitoring of lymphocyte subsets may provide useful information on immunological events during cytomegaloviral infection.
Essa
Sahar
S
Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Kuwait 13110, Kuwait. sahar@hsc.kuniv.edu.kw
Pacsa
Alexander S
AS
Raghupathy
Raj
R
Al-Attiyah
Raja'a
R
El-Shazly
Amany
A
Said
Tareq
T
D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000097:blood; D017252:CD3 Complex / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000276:immunology* / Q000821:virology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology
D000956:Antigens, Viral; D017252:CD3 Complex