Successful tolerance induction to spiramycin in pregnancy.
We report the cases of 2 pregnant patients, suffering from toxoplasmosis, who developed an erythematous, maculopapular rash during spiramycin therapy that disappeared with discontinuation of the drug. The 2 patients underwent a tolerance induction protocol with spiramycin and were able to continue therapy with this drug until the end of their pregnancies, with no side-effects.
Nucera
Eleonora
E
Department of Allergology, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Rome, Italy.
Roncallo
Chiara
C
Masini
Lucia
L
Buonomo
Alessandro
A
De Pasquale
Tiziana
T
Pollastrini
Emanuela
E
Schiavino
Domenico
D
Patriarca
Giampiero
G
D000328:Adult; D003049:Coccidiostats / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D015572:Spiramycin / Q000008:administration & dosage / Q000627:therapeutic use*; D014123:Toxoplasmosis / Q000188:drug therapy*
D003049:Coccidiostats; D015572:Spiramycin