[Proarrhythmic effects of propafenone in a woman with hepatopathy: is it always a simple drug in clinical practice?].
A 65-year-old woman with a history of alcoholic liver disease and presenting with fever and vomiting was admitted to an internal medicine unit. In view of recent atrial fibrillation with inadequate heart rate control, digoxin and propafenone were included in the therapeutic regimen. After a few days sinus rhythm was restored but suddenly ventricular arrhythmias with the characteristics of a non-responsive electrical storm arose shortly following the appearance of clinical symptoms of drug intoxication.
Hrovatin
Enzo
E
U.O. di Cardiologia, Dipartimento di Emergenza, Azienda Ospedaliera S. Maria degli Angeli, Via Montereale, 24, 33170 Pordenone. e.hrovatin@tin.it
Piazza
Rita
R
Brieda
Marco
M
Dametto
Ermanno
E
Zardo
Fabio
F
Burelli
Claudio
C
Cassin
Matteo
M
Nicolosi
Gian Luigi
GL
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis / Q000401:mortality; D001281:Atrial Fibrillation / Q000188:drug therapy; D004077:Digoxin / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000150:complications*; D011405:Propafenone / Q000009:adverse effects*
D000889:Anti-Arrhythmia Agents; D011405:Propafenone; D004077:Digoxin