New genomic avenues in behavioural neuroendocrinology.
Neuroendocrine systems play a key role not only in the maintenance of whole-body homeostasis but also as the link between behavioural, endocrine and autonomic responses to environmental stimuli. It is becoming increasingly clear that neuroendocrine regulatory mechanisms are under the control of a combination of factors including genetic background, environment and early-life programming. Patterns of gene expression are increasingly being used to provide information on the genotypes associated with particular behaviours, and modulation of specific parts of the genome allow investigation of the contribution of particular genes. The sequencing of the genome provides a unique opportunity to elucidate the genetic contribution to neuroendocrine and behavioural processes, and to investigate the interactions between genetic and environmental factors. Although drugs can be used to activate or inhibit neurotransmitters and receptors, they lack specificity. New technologies now permit the activation or inactivation of both neurotransmitters and receptors in specific areas of the brain for defined periods, including crucially important developmental windows when activation appears to have long-term consequences. The future challenges are to define the critical mechanisms through which the genetic constitution of an individual human or experimental animal interacts with environmental cues to result in altered physiological or even pathological behaviour and endocrine function.
University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, UK. stafford.lightman@bristol.ac.uk
S L
SL
Lightman
T R
TR
Insel
C D
CD
Ingram
D000818:Animals; D001519:Behavior / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D004777:Environment; D005786:Gene Expression Regulation / Q000235:genetics*; D016678:Genome; D023281:Genomics / Q000639:trends*; D005838:Genotype; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D009490:Neurosecretory Systems / Q000502:physiology*