[Effect of Ganoderma polysaccharides on cAMP in murine peritoneal macrophages].
OBJECTIVE
Investigating the effect of GLB7 on cAMP in murine peritoneal macrophages to provide a scientific evidence for the immunomodulatory mechanism.


METHODS
Cell culture and radio-immunological assay of cAMP were used.


RESULTS
GLB7 increased the production of cAMP in a concentration and time dependent manner in murine peritoneal macrophages.


CONCLUSIONS
The immunopotentiating effect of GLB7 may be due to the activation of macrophages that leads to the increase of cAMP.
Department of Pharmacy, Navy 401 Hospital, Shandong, Qingdao 266071, China.
M C
MC
Li
D S
DS
Liang
Z M
ZM
Xu
L S
LS
Lei
S Q
SQ
Yang
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D020940:Reishi / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; D000242:Cyclic AMP