No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment.
We investigated the association between serotonergic polymorphisms and incidence of nausea, which is the most frequent side-effect of selective serotonin reuptake inhibiters (SSRIs), in 66 patients treated with fluvoxamine in a protocolized-dosing method. We focused on three polymorphisms of serotonin (5-HT) neuronal systems such as 5-HT transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), a variable number of tandem repeat (VNTR) polymorphism in the second intron of the 5-HTT gene (STin2) and tryptophan hydroxylase (TPH) gene polymorphism in intron 7 (TPH-A218C), which have been reported to possess positive association with treatment response to SSRIs. In addition to this, the relationship between development of nausea and treatment response was also analyzed. Results suggested that these three polymorphisms did not affect the development of fluvoxamine-induced nausea, and that incidence of nausea was not a phenomenon that predicts the treatment response to fluvoxamine.
Takahashi
Hitoshi
H
Department of Psychiatry, Akita University School of Medicine, 1-1-1, Hondo, 010-8543, Akita, Japan. hito.takahashi@hotmail.com
Yoshida
Keizo
K
Ito
Kenich
K
Sato
Kazuhiro
K
Kamata
Mitsuhiro
M
Higuchi
Hisashi
H
Shimizu
Tetsuo
T
Ito
Kunihiko
K
Inoue
Kazuyuki
K
Tezuka
Takehiko
T
Suzuki
Toshio
T
Ohkubo
Tadashi
T
Sugawara
Kazunobu
K
D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002352:Carrier Proteins / Q000235:genetics*; D016009:Chi-Square Distribution; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D009325:Nausea / Q000139:chemically induced*; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins; D014365:Tryptophan Hydroxylase / Q000235:genetics
D018687:Antidepressive Agents, Second-Generation; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D014365:Tryptophan Hydroxylase; D016666:Fluvoxamine