Silica-based artificial protease exploiting aldehyde groups as catalytic elements.
An artificial protease synthesized by covering the surface of silica gel with aldehyde and indole groups effectively hydrolyzed albumin and gamma-globulin. It is proposed that the aldehyde group is involved in both complexation of the protein substrate and the catalytic cleavage of the peptide bonds of the complexed proteins.
School of Chemistry and Center for Molecular Catalysis, Seoul National University, 151-747, Seoul, Republic of Korea.
Hyunsook
H
Kim
Hyesun
H
Paik
Myoung-soon
MS
Kim
Yeon
Y
Chung
Junghun
J
Suh
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D012822:Silicon Dioxide / Q000737:chemistry*
D000447:Aldehydes; D012822:Silicon Dioxide; D010450:Endopeptidases