[Potential role of leptin and insulin resistance assessed by the glucose clamp technique in coronary artery disease].
OBJECTIVE
Leptin may correlate with insulin resistance and be an important factor in patients with coronary artery disease. Therefore, we examined whether plasma leptin levels and insulin resistance are linked with coronary artery disease.


METHODS
Plasma leptin levels and insulin resistance, assessed by the hyperinsulinemic euglycemic clamp technique, were measured in control subjects (n = 12, mean age 62 +/- 10 years), and in patients with obstructive coronary artery disease (n = 15, mean age 64 +/- 8 years) or vasospastic angina (n = 12, mean age 62 +/- 12 years).


RESULTS
Plasma leptin levels were significantly higher (p < 0.017) in patients with obstructive coronary artery disease (8.4 +/- 2.7 ng/ml) and vasospastic angina (7.9 +/- 2.1 ng/ml) than in patients without obstructive coronary artery disease (4.7 +/- 1.4 ng/ml). Mean glucose infusion rate was significantly (p < 0.017) lower in patients with obstructive coronary artery disease (4.39 +/- 1.78 mg/kg/min) and vasospastic angina (3.57 +/- 1.72 mg/kg/min) than in patients without obstructive coronary artery disease (8.74 +/- 1.05 mg/kg/min). The plasma levels of leptin were negatively correlated with mean glucose infusion rate (r = -0.67, p < 0.01). The other coronary risk factors were similar in these three groups.


CONCLUSIONS
Plasma leptin levels are correlated with insulin resistance and may be associated with coronary artery disease.
First Department of Internal Medicine, Tsurumi University School of Dental Science, Kanagawa.
Mari
M
Isoda
Kaname
K
Kiuchi
Jun
J
Nejima
Teruo
T
Takano
D000368:Aged; D000788:Angina Pectoris, Variant / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D020738:Leptin