No difference in clinical progression between patients infected with the predominant human immunodeficiency virus type 1 circulating recombinant form (CRF) 02_AG strain and patients not infected with CRF02_AG, in Western and West-Central Africa: a four-year prospective multicenter study.
To compare human immunodeficiency virus (HIV) type 1 disease progression in patients infected by the predominant strain circulating recombinant form (CRF) 02_AG in western and west-central Africa and in patients infected by other strains, a prospective multicenter cohort study was conducted in Cameroon and Senegal. Among the 335 patients, a broad HIV-1 group M subtype diversity was observed in the envelope V3-V5 region, but strain CRF02_AG predominated in both Cameroon and Senegal (61.2% and 62.9%, respectively; P<.8). Multivariate analyses showed no difference between patients infected by CRF02 strains and those infected by other strains in terms of survival (adjusted hazards ratio [HR], 1.16; 95% confidence interval [CI], 0.76-1.78; P=.5), clinical disease progression (HR, 0.79; 95% CI, 0.50-1.25; P=.3), or square root CD4 cell decline (regression coefficient, -0.01; 95% CI, -0.82 to 0.81; P=.9). This study suggests that the predominance of HIV-1 CRF02_AG strain in western and west-central Africa should have no major clinical consequences.
Laurent
Christian
C
Institut de Recherche pour le Développement (IRD-UR 36) and Department of International Health, University of Montpellier, France. christian.laurent@mpl.ird.fr
Bourgeois
Anke
A
Faye
Mame Awa
MA
Mougnutou
Rose
R
Seydi
Moussa
M
Gueye
Mandoumbé
M
Liégeois
Florian
F
Kane
Coumba Touré
CT
Butel
Christelle
C
Mbuagbaw
Josephine
J
Zekeng
Léopold
L
Mboup
Souleymane
S
Mpoudi-Ngolé
Eitel
E
Peeters
Martine
M
Delaporte
Eric
E
D000328:Adult; D018791:CD4 Lymphocyte Count; D002163:Cameroon / Q000453:epidemiology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000401:mortality* / Q000503:physiopathology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D011995:Recombination, Genetic; D012675:Senegal / Q000453:epidemiology; D016019:Survival Analysis