Relationship between CD4(+)/CD8(+) T cell ratio and T cell activation in multiple myeloma: reference to IL-16.
We found that the ratio of CD4(+) to CD8(+) T cells (CD4/CD8 ratio) was decreased in patients with multiple myeloma (MM) and that this decrease was significantly related to an increase of human leukocyte antigen (HLA)-DR expression by CD8(+) (but not CD4(+)) T cells (P<0.005). In addition, the serum level of interleukin (IL)-16 was significantly higher in stage III MM patients than in healthy controls (P<0.001). The decrease of CD4(+) T cells in MM may be mediated by activation of CD8(+) T cells derived cytokine IL-16. In addition, these T cell phenotypic changes and the IL-16 level appear to be useful indicators of disease activity.
Department of Internal Medicine, Juntendo University Izu-Nagaoka Hospital, 1129 Nagaoka, Izu-Nagaoka, Tagata-gun, Shizuoka, Japan
Michiaki
M
Koike
Iwao
I
Sekigawa
Makiko
M
Okada
Michio
M
Matsumoto
Noboru
N
Iida
Hiroshi
H
Hashimoto
Kazuo
K
Oshimi
D015415:Biomarkers / Q000097:blood; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D019410:Interleukin-16 / Q000097:blood; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D009101:Multiple Myeloma / Q000097:blood* / Q000209:etiology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D015415:Biomarkers; D006684:HLA-DR Antigens; D019410:Interleukin-16