The relationship between the thyroid gland and the liver.
Thyroxine and tri-iodothyronine are essential for normal organ growth, development and function. These hormones regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic function; the liver in turn metabolizes the thyroid hormones and regulates their systemic endocrine effects. Thyroid dysfunction may perturb liver function, liver disease modulates thyroid hormone metabolism, and a variety of systemic diseases affect both organs. We highlight the intricate relations between the thyroid gland and the liver in health and disease.
Malik
R
R
Centre for Hepatology, Department of Medicine, Royal Free Campus, Royal Free and University College Medical School, London, UK. r.malik@rfc.ucl.ac.uk
Hodgson
H
H
D002908:Chronic Disease; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology*; D008107:Liver Diseases / Q000150:complications / Q000378:metabolism*; D015398:Signal Transduction; D013959:Thyroid Diseases / Q000150:complications / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism
D013963:Thyroid Hormones