Enhanced mutation and neoplastic transformation in human cells by 29 kVp relative to 200 kVp X rays indicating a strong dependence of RBE on photon energy.
The fundamental assumption implicit in the use of the atomic bomb survivor data to derive risk estimates for occupational and medical exposures is that the gamma rays of Hiroshima and Nagasaki are considered as equal efficiencies to other low LET radiations up to an LET of 10 keV.micron-1. For breast cancer induction, neoplastic cell transformation, mutation, reciprocal translocations and dicentrics in human lymphocytes, a strong and very similar dependence of the RBE values on photon energy or on LET is observed. Experimental data on mutation induction and neoplastic cell transformation in human cells show that 29 kVp X rays are by a factor of 4 and 3.4, respectively, more effective compared with 200 kVp X rays. These data are in excellent agreement with the data in the literature.
Department of Clinical Radiobiology and Clinical Radiation Physics, University of Goettingen, von-Siebold Str. 3, D-37075, Goettingen, Germany. dfrank@med.uni-goettingen.de
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Frankenberg
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Kelnhofer
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Garg
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Bär
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Frankenberg-Schwager
D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D015971:Gene Expression Regulation, Enzymologic / Q000528:radiation effects; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D007564:Japan; D018499:Linear Energy Transfer; D016296:Mutagenesis; D009689:Nuclear Warfare; D017741:Survivors; D014965:X-Rays
D007041:Hypoxanthine Phosphoribosyltransferase