Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus.
Prior research has revealed that treatments that elevate the level of the pro-inflammatory cytokine IL-1beta in the brain, if given after training, impair contextual but not auditory-cue fear conditioning. The present experiments add to these finding by showing that, (a) IL-1beta exerts its effect on contextual fear conditioning by impairing consolidation processes that support the storage of the memory representation of the context; (b) the dorsal hippocampus is a critical site for the effect of IL-1beta; (c) the effect of IL-1beta cannot be attributed to its effect on glucocorticoid levels; and (d) IL-1beta injected into dorsal hippocampus either, immediately, 3, or 24 h, but not 48 h, after training produces this impairment. At this time the mechanisms responsible for this impairment are not understood, but may involve late-phase protein synthesis processes associated with LTP, because later consolidation processes are being disrupted.
Department of Psychology and The Center for Neuroscience, University of Colorado at Boulder, CB345, Boulder, CO 80309, USA. rbarr@psych.colorado.edu
Ruth M
RM
Barrientos
Emily A
EA
Higgins
David B
DB
Sprunger
Linda R
LR
Watkins
Jerry W
JW
Rudy
Steven F
SF
Maier
D000818:Animals; D003345:Corticosterone / Q000097:blood; D005239:Fear / Q000523:psychology; D006624:Hippocampus / Q000187:drug effects*; D006801:Humans; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology
D007375:Interleukin-1; D011994:Recombinant Proteins; D003345:Corticosterone