The influence of physicochemical properties of amino acid on their release from the Zn(II)-amino acid complexes in suspension.
The release processes of selected amino acids, for the parenteral administration, from the Zn(II)-Amino acid complexes in suspension were investigated in vitro. The Zn(II)-Amino acid complex dissociated and Zn(II) ions and amino acid were released. Tyrosin, possessing the highest affinity vs. the Zn(II) was released from the complexes in a continuous (monotonous) manner. Histidine, cysteine and alanine were released in a pulsating manner. The molar ratio Zn(II)-Amino acid determined the release rate and the manner of pulsating or continuous release of amino acids studied. The lower the molar ratio Zn(II)-Amino acid was, the longer was the amino acid release time form the complex. Molecular weight of the amino acids and their affinity vs. Zn(II) considerably influenced the continuous release rate from the complex. The higher the molecular weight of an amino acid, the lower was its extent of the release from the complex. The amino acids possessing higher affinity vs. Zn(II) were more slowly released too. The slowest release was observed for tyrosine which possessed the aromatic chemical structure, and the quickest release was in the case of the aliphatic amino acid--alanine. The obtained complexes were characterised by the moderated release of the amino acids in vitro.
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, Sosnowiec, Kasztanowa, Poland.
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B
Dolińska
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F
Ryszka
D000596:Amino Acids / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008970:Molecular Weight; D013056:Spectrophotometry, Ultraviolet; D013535:Suspensions; D015032:Zinc / Q000737:chemistry*
D000596:Amino Acids; D013535:Suspensions; D015032:Zinc