A narcotic dose of carbon monoxide induces neuronal haeme oxygenase and nitric oxide synthetase in sheep.
Twelve Romney ewes were exposed to either 1% carbon monoxide (CO) in air (n=6) or room air alone for 120 min and were killed 15 days later for histological and immunohistochemical examination. This dose of CO was narcotic and induced both haeme oxygenase and nitric oxide synthetase in brain neurons, but not in endothelial cells. The mechanism of the induction is not established here, but cellular theories of CO toxicity will need to be re-examined given these results.
Gorman
Des
D
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand. desmob@attglobal.net
Huang
Y L
YL
Williams
Chris
C
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002248:Carbon Monoxide / Q000633:toxicity*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D007150:Immunohistochemistry; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052248:Nitric Oxide Synthase Type I; D012756:Sheep; D012890:Sleep / Q000187:drug effects
D002248:Carbon Monoxide; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D006419:Heme Oxygenase (Decyclizing)