[Hpv cofactors in cervical carcinogenesis].
Human papillomavirus (HPV) plays a central rule in uterine cervix carcinogenesis. Other factors direct or indirectly influence the installation of this mechanism in cervical squamous epithelium. Investigations regarding mechanisms of interaction of these factors with viral elements are found in the literature of the last 20 years. The present review article discusses possible co-factors of HPV in the genesis of the squamous carcinoma of uterine cervix, taking into account only the factors whose association with the virus or cervical cancer has been documented by experimental studies, and not based just on clinical or epidemiological data. Among the approached parameters are immunological factors (local and humoral immune response), the association with Acquired Immune Deficiency Syndrome, genetic factors as protein p53 polymorphism, tabagism and the use of oral contraceptives. All these factors interact in variable intensity with oncoproteins and other HPV elements, increasing and facilitating the virus action in host cells, leading to the development of immortalization and carcinogenesis.
Pinto
Alvaro P
AP
Serviço de Anatomia Patológica, Hospital de Clínicas da UFPR e Laboratório de Citopatologia, Anatomia Patológica e Patológia Molecular ANNALAB, Curitiba, PR.
Tulio
Siumara
S
Cruz
Olívia Russo
OR
D002294:Carcinoma, Squamous Cell / Q000821:virology*; D005260:Female; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000032:analysis; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications*; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014412:Tumor Virus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000821:virology*
D009856:Oncogene Proteins, Viral; D016159:Tumor Suppressor Protein p53