Reflections on a novel therapeutic candidate.
Aptamers composed of L-nucleic acids, Spiegelmers, were selected to specifically bind GnRH. Spiegelmer inhibition of GnRH activity was demonstrated in both cellular and animal models. Rabbit studies showed minimal immunogenic response to the agents.
Sooter
Letha J
LJ
Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, University of Texas at Austin, 78712, USA.
Ellington
Andrew D
AD
D000818:Animals; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D015723:Gene Library; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D009696:Nucleic Acids / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D009696:Nucleic Acids; D007987:Gonadotropin-Releasing Hormone