[Myocardial fatty acid imaging with 123I-BMIPP in patients with chronic right ventricular pressure overload: clinical significance of reduced uptake in interventricular septum].
Regionally reduced 123I-BMIPP uptake in the interventricular septum (SEP) is observed in some patients with chronic right ventricular (RV) pressure overload. We studied the significance of this finding by comparing it with mean pulmonary arterial pressure (mPAP). 123I-BMIPP SPECT imaging was carried out in 21 patients with pulmonary hypertension (PH; 51(+)-14 years; 11 men and 10 women; 7 with primary pulmonary hypertension, 11 with pulmonary thromboembolism, and 3 with atrial septal defect). mPAP ranged from 25 to 81 mmHg (49 +/- 16 mmHg). Using a midventricular horizontal long-axis plane, regional BMIPP distributions in the RV free wall and SEP were estimated by referring to those in the LV free wall. Count ratios of the RV free wall and SEP to the LV free wall (RV/LV, SEP/LV) were determined by ROI analysis. RV/LV showed a linear correlation with mPAP (r = 0.42). However, SEP/LV was inversely correlated with mPAP (r = -0.49). When SEP/RV was compared among three regions of SEP in each patient, basal SEP/RV was most sensitively decreased in response to increased mPAP (r = -0.70). These results suggest that the assessment of septal tracer uptake in 123I-BMIPP SPECT imaging is useful for evaluating the severity of RV pressure overload in patients with PH.
Yoshiro
Y
Hori
Yoshio
Y
Ishida
Kazuki
K
Fukuchi
Kouhei
K
Hayashida
Makoto
M
Takamiya
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006346:Heart Septum / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon; D017725:Ventricular Pressure
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid