Catalytic Enantioselective Addition of Nitro Compounds to Imines-A Simple Approach for the Synthesis of Optically Active β-Nitro-α-Amino Esters.
The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to α-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave β-nitro-α-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient conditions.
Center for Metal-Catalyzed Reactions Department of Chemistry, Aarhus University 8000 Aarhus C, Denmark, Fax: (+45) 8619-6199.
N
N
Nishiwaki
K
K
Rahbek Knudsen
K V
KV
Gothelf
K A
KA
Jørgensen
Lewis acids; amino acids; asymmetric catalysis; imines; nitro compounds