CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?
During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.
Department of Genetics University of Cambridge, Downing Street, CB2 3EH, Cambridge, UK. ama11@cus.cam.ac.uk
Alfonso
A
Martinez Arias
Vincent
V
Zecchini
Keith
K
Brennan
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051880:Receptors, Notch; D015398:Signal Transduction; D014921:Wings, Animal / Q000196:embryology*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch