Toxicity of tannins towards the free-living nematode Caenorhabditis elegans and the brine shrimp Artemia salina.
Toxicities of gallo- and condensed tannins towards the free-living nematode Caenorhabditis elegans is dependent on the tannins' molecular sizes. In the present paper we investigate the toxicity of ellagitannins to C elegans and the toxicity of ellagi-, gallo-, and condensed tannins to the brine shrimpArtemia salina. Ellagitannins 1 and 2 were isolated from Euphorbia supina and identified as tellimagrandin I and rugosin A methyl ester, respectively. An ellagitannin preparation from Cornus officinalis was chromatographically fractionated into ellagitannins A through H, having different molecular weights and specific rotations. Three of the ten ellagitannins, 2, G, and H produced significant toxicity towards C. elegans, showing the presence of an activity-structure relationship, as opposed to the results from tests of gallo- and condensed tannins. Ellagi-, gallo-, and condensed tannins also produced toxicity in A. salina.
Yamasaki
Toru
T
yamasaki@ag.kagawa-u.ac.jp
Sato
Masashi
M
Mori
Tomoaki
T
Mohamed
Ahmed S A
AS
Fujii
Kyoko
K
Tsukioka
Junko
J
D000818:Animals; D001156:Artemia; D017173:Caenorhabditis elegans; D007928:Lethal Dose 50; D008970:Molecular Weight; D013329:Structure-Activity Relationship; D013634:Tannins / Q000633:toxicity*
D013634:Tannins