Chlamydia pneumoniae seropositivity and early carotid atherosclerosis in a suburban Japanese population.
To evaluate the association between Chlamydia pneumoniae (C. pneumoniae) infection and carotid atherosclerosis (CA), we investigated CA assessed by carotid B-mode ultrasound and known or suspected atherosclerotic risk factors including C. pneumoniae IgG and IgA antibodies in 2410 residents (mean age 54.5+/-13.6 years, 697 men) of a suburban Japanese town. CA was found in 30.1% of men and in 14.0% of women, IgG in 59.4% and in 51.4%, and IgA in 36.9% and in 32.4%, respectively. In univariate analysis, most conventional atherosclerotic risk factors and IgA antibody were significantly associated with CA in both sexes, but not IgG. In multivariate logistic regression analysis, independent risk factors for CA were confirmed with age and triglycerides (TG) in men and age, systolic blood pressure, pack-years of smoking, and low-density lipoprotein cholesterol (LDL-C) in women, but not IgG and IgA in either sex. These results do not support C. pneumoniae infection as an important risk factor for CA in this Japanese population.
Department of Environmental Medicine and Infectious Diseases, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Naoyasu
N
Maeda
Yasunori
Y
Sawayama
Masafumi
M
Tatsukawa
Chie
C
Shimizu
Seizaburo
S
Kashiwagi
Jun
J
Hayashi
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis*; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D023521:Chlamydophila Infections / Q000175:diagnosis* / Q000453:epidemiology*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011159:Population Surveillance; D011336:Probability; D012044:Regression Analysis; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D012720:Severity of Illness Index; D017678:Sex Distribution; D013383:Suburban Population; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
D000907:Antibodies, Bacterial