Short communication: milk fat response to low doses of tran-10, cis-12 conjugated linoleic acid (CLA).
Trans-10, cis-12 conjugated linoleic acid (CLA) is a potent inhibitor of milk fat synthesis. We examined the effect of low doses of trans-10, cis-12 CLA using Holstein cows in a 4 x 4 Latin square design. Milk yield and milk protein were unaffected, but abomasal infusion of 1.25, 2.5, and 5.0 g/d of trans-10, cis-12 CLA reduced milk fat yield by 7, 16, and 29%, respectively. When combined with previous data, the reduction in milk fat yield was curvilinear, relating to both quantity infused and milk fat content of trans-10, cis-12 CLA (R2 = 0.99 and 0.96, respectively). Further, changes in milk fatty acid composition indicated the mechanism involved inhibition of de novo fatty acid synthesis and the utilization of circulating fatty acids.
Peterson
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DG
Department of Animal Science, Cornell University, Ithaca, NY 14853, USA.
Baumgard
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LH
Bauman
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DE
D000018:Abomasum; D000818:Animals; D002417:Cattle / Q000378:metabolism / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D007774:Lactation; D019787:Linoleic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D008055:Lipids / Q000032:analysis / Q000096:biosynthesis*; D008892:Milk / Q000737:chemistry* / Q000378:metabolism; D011897:Random Allocation; D013237:Stereoisomerism
D005231:Fatty Acids, Unsaturated; D008055:Lipids; D019787:Linoleic Acid