Formins: taking a ride on the barbed end.
Formins are an ancient family of cell polarity regulators. Until recently, they were implicated in actin cytoskeleton regulation without a specific molecular function. That may all have changed with the publication of new results from several labs.
Bear
James E
JE
Deptartment of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge 02139, USA.
D008841:Actin Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D016764:Cell Polarity / Q000502:physiology*; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D005656:Fungal Proteins / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D017434:Protein Structure, Tertiary / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000166:cytology / Q000378:metabolism
C105191:Bni1 protein, S cerevisiae; D002352:Carrier Proteins; D005656:Fungal Proteins; D008840:Microfilament Proteins; D029701:Saccharomyces cerevisiae Proteins