[Mechanisms of atrial fibrillation].
Atrial fibrillation occurs because of a complex interaction between an arrhythmogenic substrate, triggers factors and the autonomic nervous system. Underlying fundamental mechanisms are multiple, can cohabit and include schematically: multiple wavelet, stable microreentry, macro single meandering spiral wave reentry and focal atrial fibrillation arising from the pulmonary veins. More over, new concepts have emerged like the atrial fibrillation-induced electrical and structural remodeling which favors its own perpetuation. Experimental studies have shown a complex interaction between anatomical particularities of the atria and the activation fronts dynamic. All this recent progress open new and more efficient therapeutic perspectives for patients enduring atrial fibrillation.
Fareh
Samir
S
Groupe de rythmologie interventionnelle Polyclinique de Rillieux 69140 Rillieux-la-Pape. samirfareh@yahoo.com
Atallah
Georges
G
D001281:Atrial Fibrillation / Q000503:physiopathology* / Q000628:therapy; D001341:Autonomic Nervous System / Q000502:physiology; D017147:Defibrillators, Implantable; D006325:Heart Atria / Q000473:pathology; D006801:Humans