Clinical efficacy of an optimized stannous fluoride dentifrice, Part 5: A 3-month study of extrinsic tooth staining, northeast USA.
The objective of this 3-month, double-blind clinical study was to investigate the level of tooth staining associated with the use of Colgate Optimized Stannous Fluoride (COSF) dentifrice compared to the tooth staining associated with two commercially available dentifrices. The results of this clinical study support the conclusion that the intensity and extent of extrinsic tooth stain associated with the use of the COSF dentifrice are significantly lower than that associated with Crest Gum Care Toothpaste. Further, this study provided no indication that the use of the COSF dentifrice is associated with a greater level of stain than that associated with the use of Crest Regular Toothpaste, a standard 0.243% sodium fluoride/silica dentifrice.
Bosma
M L
ML
Hill Top Research, Inc. East Brunswick, New Jersey, USA.
Besho
R W
RW
Walley
D
D
Mankodi
S
S
Petrone
M E
ME
Chaknis
P
P
DeVizio
W
W
Volpe
A R
AR
Proskin
H M
HM
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001628:Beverages; D002626:Chemistry, Pharmaceutical; D002951:Citrates / Q000737:chemistry; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005502:Food; D005942:Gluconates / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009515:New Jersey; D012822:Silicon Dioxide / Q000737:chemistry; D012907:Smoking; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D013223:Statistics as Topic; D017971:Tin Compounds / Q000737:chemistry; D014002:Tin Fluorides / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D014003:Tin Polyphosphates / Q000737:chemistry; D014075:Tooth Discoloration / Q000139:chemically induced* / Q000145:classification
D002951:Citrates; D003802:Dentifrices; D005942:Gluconates; D017971:Tin Compounds; D014002:Tin Fluorides; D014003:Tin Polyphosphates; C023599:stannous chloride; D012822:Silicon Dioxide; D012969:Sodium Fluoride; C030691:gluconic acid