5-hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios.
Indonesian specimens of the marine sponges Hyrtios erectus and H. reticulatus were found to contain 5-hydroxytryptamine-derived alkaloids. Their structures were determined on the basis of their spectral properties. H. erectus contained hyrtiosulawesine (4), a new beta-carboline alkaloid, together with the already known alkaloids 5-hydroxyindole-3-carbaldehyde (1), hyrtiosin B (2), and 5-hydroxy-3-(2-hydroxyethyl)indole (3). H. reticulatus contained the novel derivative 1,6-dihydroxy-1,2,3,4-tetrahydro-beta-carboline (11) together with serotonin (5), 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline (7), and 6-hydroxy-3,4-dihydro-1-oxo-beta-carboline (9).
Laboratory of Bio-organic Chemistry, Department of Organic Chemistry, Faculty of Sciences, CP 160/06, University of Brussels, 50 Av. F.D. Roosevelt, Belgium.
Mostafa
M
Salmoun
Christine
C
Devijver
Désiré
D
Daloze
Jean-Claude
JC
Braekman
Rob W M
RW
van Soest
D000818:Animals; D002855:Chromatography, Thin Layer; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D007214:Indonesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
C466377:5-hydroxyindole-3-carbaldehyde; D026121:Indole Alkaloids; C466378:hyrtiosin B; C466374:hyrtiosulawesine; D012701:Serotonin; C466375:5-hydroxy-3-(2-hydroxyethyl)indole