An effective procedure for the acylation of azaindoles at C-3.
Conditions for attachment of acetyl chloride, benzoyl chloride, and chloromethyl oxalate to the 3-position of 4-, 5-, 6-, or 7-azaindoles were explored. Best results were achieved with an excess of AlCl(3) in CH(2)Cl(2) followed by the addition of an acyl chloride at room temperature.
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
Zhongxing
Z
Zhang
Zhong
Z
Yang
Henry
H
Wong
Juliang
J
Zhu
Nicholas A
NA
Meanwell
John F
JF
Kadow
Tao
T
Wang