The effects of inhalation of a novel nitric oxide donor, DETA/NO, in a patient with severe hypoxaemia due to acute respiratory distress syndrome.
Aerosolized NONOates have been investigated in animal models in acute pulmonary hypertension, but none have been used in humans. We report the first use of aerosolized diethylenetriamine nitric oxide adduct (DETA/NO), a NONOate, in a patient with severe acute respiratory distress syndrome. Both pulmonary vascular resistance index and mean pulmonary arterial pressure were reduced by a mean of 26% and 18% respectively after the administration of a single dose of DETA/NO (150 micromol). Intrapulmonary shunting also improved. There were no significant changes in systemic arterial pressure or arterial methaemoglobin concentration after DETA/NO inhalation. We conclude that DETA/NO aerosol produced selective pulmonary vasodilation, with an improvement in pulmonary haemodynamics and oxygenation, while having no measurable effect on the systemic circulation.
Department of Pharmacology, University of Western Australia, Perth.
C F
CF
Lam
P V
PV
van Heerden
S
S
Sviri
B L
BL
Roberts
K F
KF
Ilett
D000280:Administration, Inhalation; D000336:Aerosols; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D008297:Male; D020030:Nitric Oxide Donors / Q000008:administration & dosage* / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D011073:Polyamines / Q000008:administration & dosage* / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D014655:Vascular Resistance / Q000187:drug effects
D000336:Aerosols; D020030:Nitric Oxide Donors; D011073:Polyamines; C005391:diethylenetriamine; D010100:Oxygen