Minor steroidal alkaloids from the marine sponge Corticium sp.
Four new steroidal alkaloids, plakinamine G (1), plakinamine H (2), 4alpha-hydroxydemethylplakinamine B (3), and tetrahydroplakinamine A (4), along with three known compounds, were isolated from the marine sponge Corticium sp. The structures of these metabolites were elucidated largely by 1D and 2D NMR methods and accurate mass measurements (HR-EIMS). Compounds 1, 2, and 4 show significant in vitro cytotoxicity.
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano, Italy.
Nicola
N
Borbone
Simona
S
De Marino
Maria
M
Iorizzi
Franco
F
Zollo
Cecile
C
Debitus
Giuseppe
G
Esposito
Teresa
T
Iuvone
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005910:Glioma; D020128:Inhibitory Concentration 50; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009514:Vanuatu
D000470:Alkaloids; D000970:Antineoplastic Agents; D013256:Steroids