Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine.
Nonalcoholic steatotic hepatitis (NASH), the most prevalent form of progressive liver disease in the United States, is considered to be a manifestation of insulin resistance syndrome. There is increasing evidence that steatosis in NASH is a result of the pathology in fat metabolism occurring in obesity and insulin resistance. For steatosis to progress to necroinflammation and fibrosis, however, the theory of mitochondrial oxidative-stress induced cellular damage is receiving wide acceptance. Treatment approaches that address these etiologies are reviewed: betaine, magnesium, and vitamin E.
Patrick
Lyn
L
lpatrick@frontier.net
D000975:Antioxidants / Q000627:therapeutic use*; D001622:Betaine / Q000627:therapeutic use*; D005234:Fatty Liver / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008082:Lipotropic Agents / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008274:Magnesium / Q000627:therapeutic use*; D009765:Obesity / Q000378:metabolism; D018384:Oxidative Stress; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D008082:Lipotropic Agents; D014810:Vitamin E; D001622:Betaine; D008274:Magnesium