Hematopoietic growth factors in drug-induced agranulocytosis.
Drug-induced agranulocytosis (DIA) is a potentially fatal disorder. Hematopoietic growth factors have been used in the treatment of DIA. We report nine cases of DIA treated with granulocyte macrophage - colony stimulating factor (GM-CSF) in a dose of 300 microg/day. All the patients had evidence of systemic infection. Mean time to reach an absolute neutrophil count of 0.5 x 10(9)/L was three days. One patient succumbed to the disease. The cause of death was multiorgan failure. No adverse events were observed with GM-CSF. We conclude that hematopoietic growth factors are useful in shortening the period of neutropenia and reducing morbidity and mortality in these patients.
Medical College Hospital, Trivandrum.
K
K
Pavithran
M
M
Thomas
D000293:Adolescent; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D002746:Chlorpromazine / Q000009:adverse effects; D003622:Dapsone / Q000009:adverse effects; D004177:Dipyrone / Q000009:adverse effects; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D012189:Retrospective Studies; D012460:Sulfasalazine / Q000009:adverse effects; D016896:Treatment Outcome
D012460:Sulfasalazine; D004177:Dipyrone; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003622:Dapsone; D002746:Chlorpromazine