Acute endothelin(A) receptor antagonism improves coronary artery compliance in coronary artery disease patients.
Endothelin (ET) exerts a tonic, stiffening effect on the common carotid artery in rats in vitro. This effect is mediated via the ET(A) receptor. The aim of this study was to examine the acute effects of ET(A) receptor antagonism on coronary artery compliance in humans. We examined 22 patients with stable angina after diagnostic coronary arteriography. Intracoronary BQ-123 (6 micromol), an ET(A) receptor antagonist (14 patients), or saline (8 patients), was infused in an artery without significant lesion over 20 min. The artery lumen area in the proximal arterial segment was measured at end diastole and end systole before and after BQ-123 or saline administration using an intravascular ultrasound catheter. Calculations were made of absolute (in mm(2)/mmHg x 10(3)) and normalized compliance index (in mmHg(-1) x 10(3)). Pulse pressure decreased from 64+/-21 to 61+/-17 mmHg after BQ-123 administration and increased from 59+/-16 to 68+/-20 mmHg after saline administration (F=9.54, P=0.006). The respective changes in absolute compliance index were from 24+/-18 to 39+/-25 and from 19+/-15 to 14+/-17 (F=6.43, P=0.02). Normalized compliance index changed from 2.5+/-2.0 to 3.6+/-2.4 and from 2.7+/-2.6 to 1.6+/-1.8 (F=11.92, P=0.002) respectively, in the two groups. Acute ET(A) receptor antagonism improves coronary artery compliance in coronary artery disease patients.
Onassis Cardiac Surgery Center, 356 Sygrou Ave, GR-17674 Athens, Greece. zskyr@otenet.gr
Zenon S
ZS
Kyriakides
Dimitrios Th
DT
Kremastinos
Fotis
F
Kolokathis
Anna
A
Kostopoulou
Michael
M
Georgiadis
David J
DJ
Webb
D000368:Aged; D000704:Analysis of Variance; D003327:Coronary Disease / Q000188:drug therapy*; D065128:Endothelin Receptor Antagonists; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D011674:Pulse; D044022:Receptor, Endothelin A; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
D065128:Endothelin Receptor Antagonists; D010456:Peptides, Cyclic; D044022:Receptor, Endothelin A; D014665:Vasodilator Agents; C072247:cyclo(Trp-Asp-Pro-Val-Leu)