Efficient synthesis of antihyperglycemic (S)-alpha-aryloxy-beta-phenylpropionic acid using a bifunctional asymmetric catalyst.
Antihyperglycemic (S)-alpha-aryloxy-beta-phenylpropionic acid was prepared using catalytic asymmetric cyanosilylation as a key reaction to construct alpha-oxycarboxylic acid moiety.
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd, takamu@shina.sankyo.co.jp
Makoto
M
Takamura
Hiroaki
H
Yanagisawa
Motomu
M
Kanai
Masakatsu
M
Shibasaki
D002384:Catalysis; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D006943:Hyperglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
D003432:Cross-Linking Reagents; D007004:Hypoglycemic Agents; D010666:Phenylpropionates