[Effects of Rg1 on calcium channel of guinea pig ventricular myocytes].
OBJECTIVE
To evaluate the effect of Rg1 (purified saponin of Panax notoginseng) on L-Ca2+ channel of guinea pig ventricular myocytes.


METHODS
The whole-cell patch clamp recording technique.


RESULTS
When the holding potential was kept at -40 mV, and the cell was depolarized to +40 mV for 150 ms at a frequency of 0.5 Hz.Rg1 10 mumol.L-1 and 30 mumol.L-1 could not reduce Bay K 8644 and nifedipine-sensitive L-type Ca2+ inward current (P > 0.05, n = 5).


CONCLUSIONS
Rg1 should not be a Ca2+ channel antagonist.
ICU, Hospital of Chinese Traditional Medicine of Guangdong Province, Fu Shan 528000.
B
B
Zhang
S
S
Jin
X
X
Kuang
W
W
Yao
G
G
Xia
M
M
Jiang
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D032383:Myocytes, Cardiac / Q000378:metabolism*; D005894:Panax / Q000737:chemistry; D018408:Patch-Clamp Techniques; D010946:Plants, Medicinal / Q000737:chemistry
D015220:Calcium Channels; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides