Emm types of invasive group A streptococcal isolates from Thai patients at King Chulalongkorn Memorial Hospital from 1995-1999.
Emm (M protein gene) typing was used to analyze group A streptococcal (GAS) clinical isolates in Thailand from in-patients at Chulalongkorn University Hospital (CUH) between January 1, 1995 and December 31, 1999. Forty GAS isolates were recovered from blood and other sterile sites from 40 patients presenting with different types of infections. A variety of emm sequences (24 types) have been reported in this study including the identification of 2 novel emm variants demonstrating the diverse population of invasive GAS isolates in Thailand. The common emm types include emm1 (5 isolates, 12.5%), emm22 (4 isolates, 10%), emm25 (3 isolates, 7.5%), emm61 (3 isolates, 7.5%), and STNS1033 (3 isolates, 7.5%). No particular emm types of GAS tend to be frequently associated with specific clinical presentation, complication, or anatomic site of infection. This report provides epidemiological information from Thailand where streptococcal infections and their sequelae are important public health problems. In addition, the results are useful for the development of a suitable M protein based vaccine in the future.
Pimtanothai
Nattiya
N
The National Streptococcal Reference Center in Thailand, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok.
Orataiwun
Pattaraporn
P
Nilgate
Sumalee
S
Suankatay
Chusana
C
Nunthapisud
Pongpun
P
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology* / Q000235:genetics*; D001483:Base Sequence; D002648:Child; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D014644:Genetic Variation; D006764:Hospitals, Community; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D017678:Sex Distribution; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000235:genetics*; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000302:isolation & purification; D013785:Thailand / Q000453:epidemiology
D004269:DNA, Bacterial