[Can neurotrophins help to repair an injured spinal cord?].
Basic information about neurotrophins, their receptors and distribution of these proteins in the central nervous system as well as their role in the development and maturity of the nervous system will be briefly reviewed in this chapter. Special emphasis will be given to the role of neurotrophins and their receptors after the damage of the nervous system. Finally, our recent data showing a possibility of increasing of endogenous pool of BDNF and NT-4 as well as their TrkB receptor in the spinal cord due to long-lasting, moderate locomotor training will be presented and discussed in terms of its clinical applicability.
Instytutu Biologii Doświadczalnej im. M. Nenckiego PAN w Warszawie.
Julita
J
Czarkowska-Bauch
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D005081:Exercise Therapy; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism*; D020813:Receptor, trkB / Q000378:metabolism; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000503:physiopathology / Q000534:rehabilitation
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D020813:Receptor, trkB; C073922:neurotrophin 4