Synthesis of 1-(2-hydroxy-3-methoxypropyl)uracils and their activity against L1210 and macrophage raw 264.7 cells.
The title compounds were obtained from appropriate 5-substituted uracil derivatives and 1,2-oxy-3-methoxypropane in the presence of sodium hydride. Under similar conditions 5-iodouracil gave 2-methoxymethyl-2,3-dihydro-oxazolo[3,2-c]pyrimidine-5,7-dione as a result of intramolecular cine type nucleophilic substitution. Cytotoxicity of 1-(2-hydroxy-3-methoxypropyl)-5-substituted uracil derivatives against L1210 and macrophage RAW 264.7 cells in vitro was examined.
Institute of Organic Chemistry and Technology, Silesian University of Technology, Krzywoustego, Poland.
Alicja
A
Copik
Jerzy
J
Suwinski
Krzysztof
K
Walczak
Joanna
J
Bronikowska
Zenon
Z
Czuba
Wojciech
W
Król
D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D004396:Coloring Agents / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000188:drug therapy*; D008264:Macrophages / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008956:Models, Chemical; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014498:Uracil / Q000138:chemical synthesis* / Q000494:pharmacology*
D004396:Coloring Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D014498:Uracil; C022616:thiazolyl blue