Age effects on body fluid distribution during exercise in the heat.
BACKGROUND
The purpose was to study the effects of age on body fluid distribution during exercise and exercise combined with heat stress.


METHODS
Ten young (Y; 23.2 +/-0.7 yr) and eight older (O; 65.3 +/- 1.0 yr) men performed two 80-min intermittent exercise bouts on a cycle ergometer at 50% VO2peak, one in a thermoneutral (N), 22 degrees C environment, the other in a hot (H), 40 degrees C environment. For each condition, changes in serum protein, albumin, and electrolytes (Cl-, Na+, K+); total body water (TBW); plasma volume (PV); and interstitial (ISF), extracellular (ECF), and intracellular (ICF) fluids were determined.


RESULTS
During exercise, [Cl-] responses increased more in O than Y (p < or = 0.05) while albumin (g) increased in Y and decreased in O (p < or = 0.05). There were no age-related differences in total protein changes nor any of the other blood parameters. PV decreased similarly for all subjects in both conditions with larger decreases in the H environment (241.8 +/- 40.3 vs. 478.3 +/- 46.0 mL). Loss of TBW was exacerbated in the H condition and significantly different (p < 0.05) between the groups (N: Y = -1.03 +/- 0.076 L, O = -0.88 +/- 0.12 L; H: Y = -1.65 +/- 0.12 L, O = -1.85 +/- 0.14 L). The O group lost more ICF (p < 0.05) (N: Y = -510.4 +/- 86.8 mL, O = -631.7 +/- 115.1 mL; H: Y = -529.3 +/- 118.0 mL, O = -928.6 +/- 118.9 mL) and less ISF (p < 0.05) (N: Y = -295.5 +/- 101.1 mL, O = 15.8 +/- 77.6 mL; H: Y = -684.6 +/- 134.5 mL, O = -397.9 +/- 165.5 mL) in both conditions.


CONCLUSIONS
There was an interactive effect between age and heat stress in TBW loss. In addition, older individuals lost more ICF and less ISF than younger individuals during prolonged exercise. These findings suggest that the utilization of ICF, rather than ISF, to preserve PV during cycling exercise at or near 50% VO2max may be an age-related compensation.
Morgan
Amy L
AL
Applied Physiology Research Laboratory, School of Exercise, Leisure, and Sport, Kent State University, OH, USA.
Sinning
Wayne E
WE
Weldy
David L
DL
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001823:Body Composition; D001826:Body Fluids / Q000502:physiology*; D001827:Body Height; D015992:Body Mass Index; D003681:Dehydration / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D018495:Fluid Shifts / Q000502:physiology*; D018882:Heat Stress Disorders / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010953:Plasma Volume
D006454:Hemoglobins