[Prenatal diagnosis for hereditary predisposition to mammary and ovarian carcinoma--defining a position].
Prenatal testing for a BRCA mutation, the hereditary trait for mammary and ovarian carcinoma, with the intention of selective termination of pregnancy in case of a female carrier is a controversial ethical issue. Based on a review of the (limited) medical literature as well as of Dutch policy statements relating to this subject, the following conclusions and recommendations are proposed: (a) the decision to opt for prenatal BRCA testing and selective termination of pregnancy in case of a BRCA mutation in the foetus cannot immediately be judged unacceptable from an ethical point of view; (b) prenatal BRCA testing is morally defensible only in case of a female foetus and if the parents at least have the intention to terminate the pregnancy if the foetus is a carrier, although the final decision is in any case up to the parents only; (c) prental testing for a BRCA mutation should only be done after extensive counselling of the parents, during which not only the medical genetic aspects but also the ethical aspects of prenatal BRCA testing are discussed.
VU Medisch Centrum, polikliniek Klinische Genetica, De Boelelaan 1117, 1081 HV Amsterdam. jm.cobben@vumc.nl
J M
JM
Cobben
A H J T
AH
Bröcker-Vriends
N J
NJ
Leschot
D000025:Abortion, Eugenic / Q000941:ethics; D001943:Breast Neoplasms / Q000235:genetics*; D026690:Ethics, Clinical; D005260:Female; D019398:Genes, BRCA1 / Q000941:ethics; D024522:Genes, BRCA2 / Q000941:ethics; D005817:Genetic Counseling / Q000941:ethics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000941:ethics; D006801:Humans; D008495:Medical Oncology / Q000941:ethics; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000941:ethics* / Q000523:psychology