On a model-based approach to radiation protection.
There is a preoccupation with linearity and absorbed dose as the basic quantifiers of radiation hazard. An alternative is the fluence approach, whereby radiation hazard may be evaluated, at least in principle, via an appropriate action cross section. In order to compare these approaches, it may be useful to discuss them as quantitative descriptors of survival and transformation-like endpoints in cell cultures in vitro--a system thought to be relevant to modelling radiation hazard. If absorbed dose is used to quantify these biological endpoints, then non-linear dose-effect relations have to be described, and, e.g. after doses of densely ionising radiation, dose-correction factors as high as 20 are required. In the fluence approach only exponential effect-fluence relationships can be readily described. Neither approach alone exhausts the scope of experimentally observed dependences of effect on dose or fluence. Two-component models, incorporating a suitable mixture of the two approaches, are required. An example of such a model is the cellular track structure theory developed by Katz over thirty years ago. The practical consequences of modelling radiation hazard using this mixed two-component approach are discussed.
Waligórski
M P R
MP
Centre of Oncology, Garncarska 11, 31-115 Kraków, Poland. z5waligo@cyf-kr.edu.pl
D008962:Models, Theoretical; D011835:Radiation Protection / Q000379:methods*; D011874:Radiometry / Q000379:methods; D012680:Sensitivity and Specificity