The Light Shall Show the Way-Or: The Conformational Changes of the Retinal Chromophore in Rhodopsin upon Light Activation.
The visual pigment rhodopsin constitutes the interface between the physical event of light absorption and the biochemical process of visual transduction within the photoreceptor cells. The signal transduction is initiated by an 11-cis→all-trans photoisomerization of the retinal chromophore of rhodopsin which causes a series of thermally driven conformational changes of the chromophore and the protein moiety. A rhodopsin conformation is generated which allows interaction with a heterotrimeric G-protein. Two recent publications follow the chromophore motions after light absorption by cross-linking experiments and by solid-state NMR spectroscopy.
Max-Planck-Institut für Strahlenchemie Stiftstrasse 34-36, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-3951. gaertner@mpi-muelheim.mpg.de.
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NMR spectroscopy; photochemistry; retinal; rhodopsin; signal transduction