Malignant pheochromocytoma with cutaneous metastases presenting with hemolytic anemia and pyrexia of unknown origin.
We describe a 43 year old female who presented with pyrexia of unknown origin associated with Coomb's negative hemolytic anemia and impaired liver function tests of six months duration. A routine abdominal computerised tomographic scan showed a mass in the left adrenal which was excised at laparotomy and histologically diagnosed as pheochromocytoma. The hemolysis continued to worsen with development of resistance to steroid therapy. Subsequently she developed multiple firm to hard painless cutaneous nodules which were aspirated for cytologic examination. The cytology picture was that of a neuroendocrine tumour with cell morphology similar to that of the adrenal pheochromocytoma. Such an association of hemolytic anemia, pyrexia and cutaneous metastases in a case of malignant pheochromocytoma has not been described earlier in the medical literature.
Srinivasan
R
R
Department of Pathology, Dermatology and General Medicine, St John's Medical College and Hospital, Bangalore, India.
Kini
Usha
U
Babu
M K
MK
Jayaseelan
Elizabeth
E
Pradeep
Rekha
R
D000005:Abdomen / Q000473:pathology; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000473:pathology*; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D009362:Neoplasm Metastasis; D010673:Pheochromocytoma / Q000150:complications / Q000556:secondary*; D012878:Skin Neoplasms / Q000150:complications / Q000556:secondary*; D014057:Tomography, X-Ray Computed