Location of quinacrine pellets in different positions of non-surgical female sterilization.
OBJECTIVE
To compare quinacrine pellets distribution in the uterine cavity between women standing up promptly after insertion and those lying down for a further 30-minutes.


METHODS
Randomized controlled trial


METHODS
Twenty women who, desired interval female sterilization, were equally randomized into 2 groups. Quinacrine pellets were inserted twice, one month apart in both groups. Transvaginal ultrasonography (TVS) was performed after insertion in order to locate the position of the quinacrine pellets. In group I, the TVS was performed after the women stood up promptly. In group II, the TVS was performed after the women lay down for 30-minute. The distribution of quinacrine pellets, measured from the uterine fundus to the lowest pellet, were compared.


RESULTS
There was no difference at the baseline and 30 minutes measurement of both groups. In the first insertion, there was statistical difference of the distance of the quinacrine pellets when compared in the same group immediately and the 30-minute measurement (Gr 1: 19.10+/-3.28 mm vs 22.30+/-3.50 mm); (Gr 2: 18.70+/-3.40 mm vs 24.40+/-5.95 mm). In the same manner, the authors found statistical difference in the same group of the second insertion (Gr 1: 21.80+/-5.39 mm vs 24.70+/-7.24 mm); (Gr 2 : 20.89+/-4.78 mm vs 28.30+/-7.59 mm)


CONCLUSIONS
There was statistical difference of quinacrine pellet distribution in uterine cavity after time. However, body movement did not effect the position of the pellets. The failure rate of quinacrine pellet insertion for non-surgical female sterilization may not be explained by the changes of position after insertion.
Wisawasukmongchol
Wirach
W
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Bunyavejchevin
Suvit
S
Veeranarapanich
Somnuek
S
Reinprayoon
Damrong
D
D000328:Adult; D004334:Drug Administration Schedule; D004343:Drug Implants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019160:Endosonography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011187:Posture; D011336:Probability; D011796:Quinacrine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013245:Sterilization, Reproductive / Q000379:methods*; D016683:Supine Position; D013785:Thailand; D013997:Time Factors; D016896:Treatment Outcome; D014599:Uterus / Q000000981:diagnostic imaging / Q000187:drug effects*
D004343:Drug Implants; D011796:Quinacrine