Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies.
To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n=365) or low-grade squamous epithelial lesions (LSILs; n=275) or who were cytologically normal (control subjects; n=681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.
Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7234, USA. wangso@mail.nih.gov
Sophia S
SS
Wang
Allan
A
Hildesheim
Xiaojiang
X
Gao
Mark
M
Schiffman
Rolando
R
Herrero
M Concepcion
MC
Bratti
Mark E
ME
Sherman
Willard A
WA
Barnes
Mitchell D
MD
Greenberg
Larry
L
McGowan
Rodrigue
R
Mortel
Peter E
PE
Schwartz
Richard J
RJ
Zaino
Andrew G
AG
Glass
Robert D
RD
Burk
Peter
P
Karacki
Mary
M
Carrington
D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D015331:Cohort Studies; D003364:Costa Rica; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D009922:Oregon; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology; D030361:Papillomavirus Infections / Q000235:genetics / Q000276:immunology; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000276:immunology* / Q000821:virology
D004279:DNA, Viral; D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I