A novel metal iodide promoted three-component synthesis of substituted pyrrolidines.
[reaction: see text] A new one-pot procedure for the synthesis of substituted pyrrolidine derivatives with commercially available cyclopropyl ketones, aldehydes, and amines by a metal iodide promoted three-component reaction was developed.
Discovery Chemistry, ACADIA Pharmaceuticals A/S, Fabriksparken 58, DK-2600 Glostrup, Denmark.
Fabio
F
Bertozzi
Magnus
M
Gustafsson
Roger
R
Olsson
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003521:Cyclopropanes / Q000737:chemistry; D007454:Iodides / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008274:Magnesium; D011759:Pyrrolidines / Q000138:chemical synthesis*
D000447:Aldehydes; D000588:Amines; D003521:Cyclopropanes; D007454:Iodides; D007659:Ketones; D011759:Pyrrolidines; D008274:Magnesium