Antibiofilm approaches: prevention of catheter colonization.
Bacteria frequently attach to medical devices such as intravascular catheters by forming sessile multicellular communities known as biofilms, which can be the source of persistent infections that are recalcitrant to systemic antibiotic therapy. As a result of this persistence, a number of technologies have been developed to prevent catheter-associated biofilm formation. Whereas the most straightforward approaches focus on impregnating catheter material with classical antimicrobial agents, these approaches are not universally effective, thereby underscoring the need for more potent and more sophisticated approaches to the prevention of catheter-related biofilm infections.
Danese
Paul N
PN
Microbia, Inc., One Kendall Square, Building 1400W, Cambridge, MA 02139, USA. pdanese@microbia.com
D018829:Adhesins, Bacterial / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms / Q000254:growth & development*; D002404:Catheterization / Q000009:adverse effects*; D002448:Cell Adhesion / Q000187:drug effects; D004866:Equipment Contamination / Q000517:prevention & control; D017053:Infection Control / Q000379:methods
D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents