A new approach to functionalized spiropiperidines through tandem RCM and nitrogen-directed reactions.
The synthesis of a functionalized spiropiperidine via a tandem ring closing metathesis strategy is described, furthermore, the regio- and stereoselective functionalization of this compound has been achieved through a novel nitrogen-directed epoxidation reaction.
Edwards
Andrew S
AS
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UK S3 7HF.
Wybrow
Robert A J
RA
Johnstone
Craig
C
Adams
Harry
H
Harrity
Joseph P A
JP