Postnatal growth and circulating ACTH and cortisol concentrations during the first month of life in cloned lambs.
Recent studies have indicated that there is a decrease in perinatal survival of apparently normal animals produced by somatic-cell nuclear transfer. Here we report that the cortisol and adrenocorticotrophic hormone (ACTH) profiles of cloned lambs in the first 4 weeks of life are significantly different to that of control lambs. The growth of cloned lambs however was not different to controls. These findings demonstrate that endocrine development may be altered in apparently "normal" clones.
Department of Physiology, University of Adelaide, Adelaide, SA 5005, Australia.
Lisa
L
Edwards
Teija
T
Peura
Katrina
K
Hartwich
Skye
S
Rudiger
I Caroline
IC
McMillen
Simon
S
Walker
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D019976:Cloning, Organism; D004624:Embryo Transfer; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D053652:Nuclear Transfer Techniques; D011247:Pregnancy; D012756:Sheep / Q000097:blood* / Q000254:growth & development*
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone