Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells.
Khare
L
L
Astrinidis
A
A
Senapedis
W
W
Adams
P D
PD
Henske
E Petri
EP
D000595:Amino Acid Sequence; D002453:Cell Cycle / Q000502:physiology; D002460:Cell Line; D005434:Flow Cytometry / Q000379:methods; D016193:G1 Phase / Q000502:physiology*; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010957:Plasmids / Q000235:genetics; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D012097:Repressor Proteins / Q000235:genetics* / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D014162:Transfection; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins
D011506:Proteins; D012097:Repressor Proteins; C000624650:TSC1 protein, human; C000624653:TSC2 protein, human; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins