Biosynthesis of cobalamin (vitamin B(12)).
The biosynthesis of vitamin B(12) is summarized, emphasizing the differences observed between the aerobic and anaerobic pathways. The biosynthetic route to adenosylcobalamin from its five-carbon precursor, 5-aminolaevulinic acid, can be divided into three sections: (1) the biosynthesis of uroporphyrinogen III from 5-aminolaevulinic acid, which is common to both pathways; (2) the conversion of uroporphyrinogen III into the ring-contracted, deacylated intermediate precorrin 6 or cobalt-precorrin 6, which includes the primary differences between the two pathways; and (3) the transformation of this intermediate to form adenosylcobalamin.
Scott
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Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA. scott@mail.chem.tamu.edu
Roessner
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D000622:Aminolevulinic Acid / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D003038:Cobamides / Q000096:biosynthesis / Q000737:chemistry; D014577:Uroporphyrinogens / Q000096:biosynthesis / Q000378:metabolism; D014805:Vitamin B 12 / Q000096:biosynthesis* / Q000737:chemistry
D003038:Cobamides; D014577:Uroporphyrinogens; D000622:Aminolevulinic Acid; C000913:cobamamide; D014805:Vitamin B 12