Do duration of exposure, proximity to electronic manufacturing plants, and involvement in a lawsuit affect chlorinated solvent toxicity?
The author examined the effects of duration of residence, proximity to microchip plants, and being a party in litigation involving neurobehavioral functioning in individuals who had been chronically exposed to trichloroethylene-associated solvents from the environment. The author compared duration of exposure for the 236 residents, all of whom were located in 3 proximity zones in Phoenix, Arizona; some of the individuals had been in the process of solvent-related litigation for fewer than 10 yr, whereas some had been involved for more than 10 yr. The 236 residents were compared with 58 nonclaimants in 3 residential areas within the exposure zones. Neurobehavioral function testing was described in the study that appears prior to this study in this issue. Prior to comparisons, test scores were adjusted for age, sex, education level, and other significant factors. Individuals who had been exposed for fewer than 10 yr were not different from individuals who had been exposed for longer periods. Proximity to microchip plants produced no statistically significant effects. Among the 169 exposed subjects (i.e., exposure for 15 yr to trichloroethylene-associated solvents), of whom some were parties in lawsuits, those who lived in the near west area (Zone A) of Phoenix did not differ with respect to results of the 14 neurobehavioral tests that were administered. However, Zone B subjects, located to the north of the plant, differed with respect to 2 of the tests; and Zone C subjects, located beyond Zone A, Phoenix, differed with respect to 3 of the tests. In conclusion, duration of residence, proximity to microchip plants, and being a party to a lawsuit had no significant effects on neurobehavioral functioning, but, in this study, parties in the lawsuit were subjects who experienced more frequent symptoms.
University of Southern California, Keck School of Medicine, Environmental Sciences Laboratory, Los Angeles, California, USA.
Kaye H
KH
Kilburn
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona / Q000453:epidemiology; D016022:Case-Control Studies; D004522:Educational Status; D004581:Electronics / Q000331:legislation & jurisprudence*; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis / Q000331:legislation & jurisprudence*; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D007221:Industry / Q000331:legislation & jurisprudence*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012111:Residence Characteristics / Q000706:statistics & numerical data*; D012997:Solvents / Q000032:analysis / Q000506:poisoning*; D013997:Time Factors; D014241:Trichloroethylene / Q000032:analysis / Q000506:poisoning*; D014504:Urban Health; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000506:poisoning*
D012997:Solvents; D014874:Water Pollutants, Chemical; D014241:Trichloroethylene