Is the male dog comparable to human? A histological study of the muscle systems of the lower urinary tract.
Because of their superficial anatomical resemblance, the male dog seems to be suitable for studying the physiologic and pathological alterations of the bladder neck of human males. The present study was carried out to compare and contrast the muscular anatomy of the male dog lower urinary tract with that of humans. The complete lower urinary tract, including the surrounding organs (bulb of penis, prostate, rectum and musculature of the pelvic floor) were removed from adult and newborn male dogs and histologically processed using serial section technique. Based on our own histological investigations, three-dimensional (3D)-models of the anatomy of the lower urinary tract were constructed to depict the corresponding structures and the differences between the species. The results of this study confirm that the lower urinary tract of the male dog bears some anatomical resemblance (musculus detrusor vesicae, prostate, prostatic and membranous urethra) to man. As with human males, the two parts of the musculus sphincter urethrae (glaber and transversostriatus) are evident in the canine bladder neck. Nevertheless, considerable differences in formation of individual muscles should be noted. In male dogs, no separate anatomic entity can be identified as vesical or internal sphincter. The individual course of the ventral and lateral longitudinal musculature and of the circularly arranged smooth musculature of the urethra is different to that of humans. Differences in the anatomy of individual muscles of the bladder neck in the male dog and man suggest that physiological interpretations of urethral functions obtained in one species cannot be attributed without qualification to the other.
Stolzenburg
Jens-Uwe
JU
Department of Urology, University of Leipzig, Stephanstr. 11, Germany. stolj@medizin.uni-leipzig.de
Schwalenberg
Thilo
T
Do
Minh
M
Dorschner
Wolfgang
W
Salomon
Franz-Viktor
FV
Jurina
Konrad
K
Neuhaus
Jochen
J
D000818:Animals; D004285:Dogs / Q000033:anatomy & histology* / Q000502:physiology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D018482:Muscle, Skeletal / Q000033:anatomy & histology* / Q000166:cytology; D009130:Muscle, Smooth / Q000033:anatomy & histology* / Q000166:cytology; D013045:Species Specificity; D014521:Urethra / Q000033:anatomy & histology / Q000502:physiology; D001743:Urinary Bladder / Q000033:anatomy & histology / Q000502:physiology; D014551:Urinary Tract / Q000033:anatomy & histology* / Q000166:cytology; D014553:Urinary Tract Physiological Phenomena