Antibiotic resistance among gram-negative bacteria of lower respiratory tract secretions in hospitalized patients.
Data on antibiotic resistance pattern of gram-negative bacterial isolates of lower respiratory tract secretions of hospitalized patients were fed into WHONET computer and analyzed for the year 1999. Out of 860 samples, 269 (31.2%) were culture positive. Gram-negative bacteria (GNB) accounted for 238 (88.4%) positive samples. Non-fermenting gram-negative bacteria (NFGNB) were found in 34% samples, the other common ones being Klebsiella spp (29.8%) and Pseudomonas spp (17.2%). GNB isolates from tracheal aspirates and sputum were 132 (55.4%) and 106 (44.5%) respectively. Adults (32.7%) and elderly patients (24.3%) recorded higher isolation of GNB as compared to pediatric patients (1.6%). The highest mean resistance among predominant GNB in both tracheal aspirate (96.6%) and sputum (86.9%) was noted to ampicillin while the lowest mean resistance in tracheal aspirate (28%) and sputum (14.3%) was to amikacin. NFGNB of tracheal aspirates and sputum showed highest resistance of 50% and 32% to amikacin, respectively. Pseudomonas spp showed the highest variation in the resistance pattern between tracheal aspirates and sputum samples. Overall mean resistance was highest among tracheal aspirate isolates compared to sputum isolates.
Department of Microbiology, M.S. Ramaiah Medical College and Teaching Hospital, Bangalore. navam1@rediffmail.com
B V
BV
Navaneeth
M R Sandhya
MR
Belwadi
D000328:Adult; D000368:Aged; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006760:Hospitalization; D006801:Humans; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology*; D013183:Sputum / Q000382:microbiology; D013396:Suction; D014132:Trachea