DNB: a partial D with anti-D frequent in Central Europe.
To improve routine D typing and define transfusion strategy, it is important to establish the frequency of partial D alleles and their susceptibility to anti-D alloimmunization due to transfusion or pregnancy. We identified the partial D DNB that was caused by an RHD(G355S) allele associated with a CDe haplotype and whose phenotype presented a normal D in routine typing. The antigen density was about 6000 D antigens per red blood cell, and the Rhesus index was 0.02. Five anti-D immunization events with allo-anti-D titers up to 128 were observed. Twelve carriers of DNB were whites of Central Europe; the only Danish proband had Austrian ancestry. DNB was the most frequent partial D recognized so far in whites, occurring with frequencies of up to 1:292 in Switzerland. DNB was the underlying partial D phenotype in a relevant fraction of anti-D immunizations occurring in whites.
Department of Transfusion Medicine, University of Ulm, DRK (German Red Cross) Blood Donation Service Baden-Württemberg-Hessen, Institute Ulm, Heimholtzstrasse 10, D-89081 Ulm, Germany. waf@ucsd.edu
Franz F
FF
Wagner
Nicole I
NI
Eicher
Jan R
JR
Jørgensen
Cornelie B
CB
Lonicer
Willy A
WA
Flegel
D000483:Alleles; D019943:Amino Acid Substitution; D001788:Blood Grouping and Crossmatching; D005060:Europe / Q000453:epidemiology / Q000208:ethnology; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008969:Molecular Sequence Data; D017354:Point Mutation; D012203:Rh Isoimmunization / Q000209:etiology; D012204:Rh-Hr Blood-Group System / Q000097:blood / Q000235:genetics* / Q000276:immunology; D018029:Rho(D) Immune Globulin
D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin; C026410:Rho(D) antigen