Decrease in minimum alveolar concentration of sevoflurane during anaesthesia and arthroscopy.
OBJECTIVE
Although the MACtetanus (minimum alveolar concentration that prevents movement in response to electrical tetanus stimulation in 50% of patients) of isoflurane decreases during anaesthesia and surgery, it is not known whether this occurs to the same extent with other inhalational anaesthetics. We determined the MACtetanus of sevoflurane before and after surgery.


METHODS
Eleven patients who underwent arthroscopy of the shoulder underwent inhalational induction of anaesthesia with sevoflurane and tracheal intubation by succinylcholine. MACtetanus was determined in each patient by testing the response to a 10 s, 50 Hz, 80 mA transcutaneous tetanic electrical stimulus to the ulnar nerve at varying concentrations of sevoflurane. The end-tidal concentration of sevoflurane was kept constant for 15 min before each stimulus and the concentration of sevoflurane varied in increments of 0.1% until a sequence of three alternate responses (move, not move, move) or (not move, move, not move) was obtained. After arthroscopy of the shoulder, individual MACtetanus were measured as described above.


RESULTS
The mean MACtetanus decreased from 2.22 +/- 0.29% before arthroscopy to 1.82 +/- 0.26% after arthroscopy (P < 0.01).


CONCLUSIONS
It is concluded that the MACtetanus of sevoflurane decreases during anaesthesia and surgery.
Self Defense Force Hanshin Hospital, Department of Anaesthesia, 4-1-50 Kushiro, Kawanishi, Hyogo 666-0024, Japan. higu-chi@ka2.so-net.ne.jp
H
H
Higuchi
Y
Y
Adachi
D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001182:Arthroscopy; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011650:Pulmonary Alveoli / Q000378:metabolism*; D000077149:Sevoflurane; D012782:Shoulder / Q000601:surgery
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane