REV-ving up the clock.
Circadian rhythms are generated by a transcription/translation feedback loop consisting of two limbs, one positive and one negative. The nuclear orphan receptor, REV-ERBalpha, is identified as a molecular link coupling these two limbs.
Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104, USA.
J D
JD
Alvarez
Amita
A
Sehgal
D000818:Animals; D001683:Biological Clocks / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics*; D004268:DNA-Binding Proteins; D005246:Feedback / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics / Q000378:metabolism*; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1; D014176:Protein Biosynthesis / Q000235:genetics*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*
D004268:DNA-Binding Proteins; C064353:NR1D1 protein, human; C498262:Nr1d1 protein, mouse; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1; D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors