[Levels of plasma TF and TFPI activities in patients with acute leukemia].
OBJECTIVE
To investigate the changes of plasma tissue factor(TF) and tissue factor pathway inhibitor(TFPI) activities in the patients with acute leukemia.


METHODS
TF and TFPI activities were measured by using chromogenic assays.


RESULTS
Plasma TF activity in the patients with acute leukemia was higher and TFPI activity was lower than those in normal(P < 0.01). In 7 patients who underwent the first chemotherapy, the plasma TF activity was decreased after chemotherapy(P < 0.01), while TFPI activity increased(P < 0.05).


CONCLUSIONS
The unbalance between plasma TF and TFPI activities contributes to the coagulant disorders in acute leukemia.
Department of Haemotology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Y
Y
Zhu
Z X
ZX
Xie
X F
XF
He
J Z
JZ
Han
J C
JC
Li
S L
SL
He
D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*; D013925:Thromboplastin / Q000378:metabolism*
D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin