[Expression of bcl-2 in acute leukemia patients and its significance].
RT-PCR method was used to detect the expression level of bcl-2 gene in 38 patients of acute leukemia.


RESULTS
Expression level of bcl-2 in the patients with clinical refractoriness increased more obviously than previously untreated and CR patients, and the expression level of bcl-2 was obviously correlated with clinical refractoriness(r = 0.83, P < 0.01), which indicated that high expression of bcl-2 was one of the factors in clinical refractoriness. It was also a sensitive method for predicting the effect of anti-tumor agents and prognosis in clinic work.
Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Z F
ZF
Jian
Y H
YH
Zhou
F P
FP
Chen
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D015870:Gene Expression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D019253:Proto-Oncogene Proteins c-bcl-2