CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects.
In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.
Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. katharina.buerger@psy.med.uni-muenchen.de
K
K
Buerger
S J
SJ
Teipel
R
R
Zinkowski
K
K
Blennow
H
H
Arai
R
R
Engel
K
K
Hofmann-Kiefer
C
C
McCulloch
U
U
Ptok
R
R
Heun
N
N
Andreasen
J
J
DeBernardis
D
D
Kerkman
H- J
H
Moeller
P
P
Davies
H
H
Hampel
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010766:Phosphorylation; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012307:Risk Factors; D013912:Threonine / Q000378:metabolism; D016875:tau Proteins / Q000134:cerebrospinal fluid* / Q000378:metabolism*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015415:Biomarkers; D016875:tau Proteins; D013912:Threonine