Pentahaem cytochrome c nitrite reductase: reaction with hydroxylamine, a potential reaction intermediate and substrate.
The pentahaem enzyme cytochrome c nitrite reductase catalyses the reduction of nitrite to ammonia, a key reaction in the biological nitrogen cycle. The enzyme can also transform nitrogen monoxide and hydroxylamine, two potential bound reaction intermediates, into ammonia. Structural and mechanistic aspects of the multihaem enzyme are discussed in comparison with hydroxylamine oxidoreductase, a trimeric protein with eight haem molecules per subunit.
Rudolf
M
M
Fachbereich Biologie, Universität Konstanz, Fach M665, D-78457 Konstanz, Germany.
Einsle
O
O
Neese
F
F
Kroneck
P M H
PM
D045263:Cytochromes a1; D003575:Cytochromes c1; D019811:Hydroxylamine / Q000378:metabolism*; D007700:Kinetics; D009565:Nitrate Reductases / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
D019811:Hydroxylamine; D045263:Cytochromes a1; D003575:Cytochromes c1; D009565:Nitrate Reductases; C054690:nitrate reductase (cytochrome)