Bone mineralisation in premature infants cannot be predicted from serum alkaline phosphatase or serum phosphate.
BACKGROUND
The bone mineral content of premature infants at term is lower than in mature infants at the same postconceptional age. Serum alkaline phosphatase and serum phosphate are often used as indicators of bone mineralisation.


OBJECTIVE
To analyse the association between bone mineral content and serum alkaline phosphatase and serum phosphate.


METHODS
Serum alkaline phosphatase and phosphate were measured at weekly intervals during admission in 108 premature infants of gestational age below 32 weeks (mean (SD) gestational age 29 (2) weeks; mean (SD) birth weight 1129 (279) g). Bone mineral content was measured at term (mean gestational age 41 weeks) by dual energy x ray absorptiometry and corrected for body size.


RESULTS
Serum alkaline phosphatase was significantly negatively associated with serum phosphate (p < 0.001). Bone mineral content was not associated with mean serum alkaline phosphatase (p = 0.8), peak serum alkaline phosphatase (p = 0.5), or mean serum phosphate (p = 0.2) at term.


CONCLUSIONS
Routine measurements of serum alkaline phosphatase and serum phosphate are of no use in predicting bone mineralisation outcome in premature infants.
Department of Paediatrics, University Clinic of Paediatrics, Hvidovre Hospital, Kettegaards allé 30, 2650 Hvidovre, Copenhagen, Denmark. jfaerk@dadlnet.dk
J
J
Faerk
B
B
Peitersen
S
S
Petersen
K F
KF
Michaelsen
D015502:Absorptiometry, Photon / Q000379:methods; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D002113:Calcification, Physiologic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000502:physiology*; D008297:Male; D010710:Phosphates / Q000097:blood*; D011446:Prospective Studies
D015415:Biomarkers; D010710:Phosphates; D000469:Alkaline Phosphatase