[Dual role of nitric oxide in the pathogenesis of diabetic nephropathy].
Nitric oxide (NO) is a key mediator in renal physiology and pathology. In diabetic nephropathy, NO may exert destructive effects (hyperfiltration, peroxynitrate-mediated tissue injury) as well as exhibit certain protective properties (reduced TGF-beta expression and extracellular matrix expansion, inhibition of platelet aggregation). Here, we briefly review the biochemistry and pathophysiology of NO, and discuss the mechanisms underlying the contrasting effects of NO in diabetic nephropathy.
Katedra Patofizjologii Akademii Medycznej, im. Karola Marcinkowskiego w Poznaniu.
Krzysztof
K
Ksiazek
Janusz
J
Witowski
D003928:Diabetic Nephropathies / Q000378:metabolism*; D018450:Disease Progression; D016166:Free Radical Scavengers / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D009569:Nitric Oxide / Q000009:adverse effects / Q000096:biosynthesis / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism
D016166:Free Radical Scavengers; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase