Longitudinal assessment of the development of diabetic polyneuropathy and associated risk factors.
OBJECTIVE
To longitudinally assess risk factors for diabetic polyneuropathy (DPN) severity, and to longitudinally assess risk factors for the change of DPN severity during 2-4 years of follow-up.


METHODS
From 1995 to 1999, 486 Type 2 diabetes patients in general practice were examined annually with regard to DPN severity and its possible risk factors. DPN severity was assessed with a clinical neurological examination (CNE) which included pinprick sense, light touch sense, vibration sense and ankle jerk. Longitudinal (multivariate) linear associations of (change of) CNE score and predicting variables were analysed using multilevel analyses.


RESULTS
In this population, 50% of participants were men and had a mean age of 65.4 years, almost one-third (31.7%) of the participants had a CNE score > 4 at baseline and were classified with DPN. CNE score significantly increased during follow-up. Among participants not graded with DPN at baseline, 21.3% progressed towards a CNE score > 4 after 3 years of follow-up. Longitudinal multivariate analyses showed that age, diabetes duration, HbA1c, height, body mass index and ankle-arm index together best predicted CNE score during follow-up. Change of CNE score during follow-up was best predicted by age, diabetes duration and HbA1c, with the latter being the strongest predictor.


CONCLUSIONS
Although several factors are longitudinally associated with DPN, HbA1c, age and diabetes duration were the best predictors of CNE change during follow-up. Therefore, improving glycaemia remains an important amenable factor in preventing worsening of diabetic polyneuropathy.
van de Poll-Franse
L V
LV
Institute for Research in extramural Medicine, Universiteit van Maastricht, The Netherlands. Ivdpoll@zonnet.nl
Valk
G D
GD
Renders
C M
CM
Heine
R J
RJ
van Eijk
J T M
JT
D017668:Age of Onset; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology*; D003929:Diabetic Neuropathies / Q000097:blood / Q000209:etiology*; D005194:Family Practice; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D012307:Risk Factors
D006442:Glycated Hemoglobin