Conditionally immortalized cell lines as model systems for high-throughput biology in drug discovery.
There is an increasing emphasis on the need for high-quality biological data much earlier in the drug-discovery process. This has led to the development of high-throughput approaches to biology, many of which rely on the use of cell-culture models. Unfortunately, available cell-culture models often reflect poorly the characteristics of the tissue they are supposed to represent. However, the conditional-immortalization approach as applied by Xcellsyz offers the possibility of producing human cell lines on demand, which are truly representative of the tissue from which they derive.
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
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N
Daniele
R
R
Halse
E
E
Grinyo
S J
SJ
Yeaman
P R
PR
Shepherd
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D002461:Cell Line, Transformed; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008954:Models, Biological