Pseudostructural inhibitors of G protein signaling during development.
Heterotrimeric G proteins mediate signal transduction pathways to control development in fungal, plant, and animal cells. A recent study in the July issue of Molecular Cell identifies three proteins that, while not displaying sequence similarity to G protein subunits, appear to act as structural mimics of a Gbetagamma dimer to negatively regulate pseudohyphal growth in budding yeast.
Biology Department, Boston College, Massachusetts 02467, USA.
F Douglas
FD
Ivey
Charles S
CS
Hoffman
D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002455:Cell Division / Q000502:physiology*; D044387:GTP-Binding Protein beta Subunits; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D046911:Macromolecular Substances; D020836:Protein Structure, Quaternary / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000254:growth & development / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000254:growth & development / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins; D015398:Signal Transduction / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; C427883:GPB-2 protein, C elegans; D044387:GTP-Binding Protein beta Subunits; D015801:Helminth Proteins; D046911:Macromolecular Substances; D029702:Schizosaccharomyces pombe Proteins; C101525:git5 protein, S pombe; D020962:Heterotrimeric GTP-Binding Proteins