Administration of low molecular weight heparin within two hours before caesarean section increases the risk of wound haematoma.
A retrospective analysis of the relation between time interval from prophylactic administration of low molecular weight heparin (LMWH) to delivery and the occurrence of wound haematoma was performed in all women, who had a caesarean section in 1998. After administration of LMWH within 2 hours of surgery, the percentage of women with a wound haematoma was significantly larger (12% vs 3%). Multivariate regression analysis, including other risk factors for wound haematoma, indicated administration of LMWH within 2 hours prior to delivery as the only statistically significant factor, which influenced the development of wound haematoma (odds ratio = 5.3, 95% CI = 1.2-22.8).
Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Room H4-205, PO Box 22660, 1100 DD Amsterdam, The Netherland.
F H
FH
van Wijk
H
H
Wolf
J M J
JM
Piek
H R
HR
Büller
D000925:Anticoagulants / Q000009:adverse effects*; D002585:Cesarean Section / Q000009:adverse effects*; D005260:Female; D006406:Hematoma / Q000139:chemically induced*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D016015:Logistic Models; D019106:Postoperative Hemorrhage / Q000139:chemically induced*; D011247:Pregnancy; D011300:Preoperative Care / Q000009:adverse effects; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight