Role of protease-activated receptors in neutrophil degranulation.
Inflammation is a process culminated by cellular components and soluble mediators act in concert to evolve a sustainable process to impart distress in vascularized tissue. The role of thrombin receptors in neutrophil degranulation is not fully understood. Thrombin-mediated signaling has been shown to occur at least in part by a family of G protein-coupled protease-activated receptors (PARs). Protease-activated receptors-1 (PAR1) is the prototype for understanding on the fundamental signaling mechanism and related characterization. The inference of thrombin receptors and various synthetic ligand formulations on neutrophil degranulation ascertained an enormous disparity in the response by human donors. Based on the previous reports and supposition in perpetuity, it is hypothesized that thrombin through its receptor, and its subtypes, may very improbably have any functional role in PMN degranulation.
Department of Physiology, School of Medicine, Temple University, Philadelphia, USA. Skannan22@hotmail.com
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D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D051379:Mice; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010446:Peptide Fragments / Q000502:physiology; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013917:Thrombin / Q000494:pharmacology*
D001095:Arachidonic Acids; D010446:Peptide Fragments; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin; C105295:protease-activated receptor 3; C082835:thrombin receptor peptide (42-47); D013917:Thrombin; C112908:protease-activated receptor 4