The core of bluetongue virus binds double-stranded RNA.
Double-stranded RNA (dsRNA) viruses conceal their genome from the host to avoid triggering unfavorable cellular responses. The crystal structure of the core of one such virus, bluetongue virus, reveals an outer surface festooned with dsRNA. This may represent a deliberate strategy to sequester dsRNA released from damaged particles to prevent host cell shutoff.
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Headington, Oxford OX3 7BN, United Kingdom.
J M
JM
Diprose
J M
JM
Grimes
G C
GC
Sutton
J N
JN
Burroughs
A
A
Meyer
S
S
Maan
P P C
PP
Mertens
D I
DI
Stuart
D001665:Binding Sites; D001820:Bluetongue virus / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D012330:RNA, Double-Stranded / Q000737:chemistry / Q000378:metabolism*; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism*; D014758:Viral Core Proteins / Q000737:chemistry / Q000378:metabolism*; D014961:X-Ray Diffraction
D012330:RNA, Double-Stranded; D012367:RNA, Viral; D014758:Viral Core Proteins; C066862:VP7 protein, orbivirus