Rare mesenchymal lesions: Hamartoma of the chest wall and juvenile active ossifying fibroma in siblings.
Mesenchymal hamartomas of the thorax are known as rare dysontogenetic tumorous non-neoplastic lesions. The juvenile active ossifying fibroma (JAOF) also is considered as a benign tumor like lesion of the mesenchymal connective tissue. The authors report the cases of 2 siblings-a 2-year-old girl with a hamartoma of the chest wall and her 4-year-old brother with a JAOF. The girl had bilocular mesenchymal hamartoma in the area of the 8(th) rib diagnosed in the first year of life, which was surgically removed completely. Her brother had been treated for JAOF of the right nasal sinus area diagnosed at the age of 15 months. Both lesions are extremely rare mutations of the local tissue, which occur typically in early childhood and continue benignly after surgical resection, but such a familial occurrence in siblings has not yet been reported. Furthermore, according to the histologic findings, the JAOF also could be seen as a hamartomatous lesion.
Departments of Pediatric Surgery, Charité Medical Center, Virchow Hospital, Humboldt University, Berlin, Germany.
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S
Golla
J
J
Wit
M
M
Guschmann
E
E
Lübbert
T
T
Kerner
D001859:Bone Neoplasms / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D018214:Fibroma, Ossifying / Q000473:pathology*; D006222:Hamartoma / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000473:pathology*; D008648:Mesoderm; D012272:Ribs / Q000000981:diagnostic imaging; D013896:Thoracic Diseases / Q000175:diagnosis*; D014463:Ultrasonography