A novel approach for the adsorption of iodine-125 on silver wire as matrix for brachytherapy source for the treatment of eye and prostate cancer.
The adsorption of iodine-125 on silver wire bits coated with palladium to be sealed in titanium capsules as brachytherapy sources was studied. A method was optimized to obtain quantitative adsorption of 125I on the palladium treated silver wires. A comparative evaluation of palladium coated and uncoated (bare) silver wires on the adsorption of 125I was made. While, the adsorption of bare silver wires showed low, inconsistent uptake (approximately 60%) of 125I with high leachability (approximately 4%), the Pd coated silver wires showed quantitative and consistent uptake of 125I (approximately 90%) and exhibited low leachability (0.01%). 125I adsorbed on Pd coated silver wires could be used as a matrix for the preparation of interstitial sources in eye and prostate cancer therapy.
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
C
C
Mathew
M A
MA
Majali
S A
SA
Balakrishnan
D000327:Adsorption; D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D005134:Eye Neoplasms / Q000532:radiotherapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008297:Male; D010165:Palladium; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D012834:Silver; D014025:Titanium
D007457:Iodine Radioisotopes; D012834:Silver; D010165:Palladium; D014025:Titanium