Potential methods to circumvent blocks in apoptosis in lymphomas.
We review our current understanding of the molecular determinants and mechanisms of lymphocyte apoptosis and identify the key regulators of these death-signaling pathways. In addition, we describe the key molecular aberrations that underlie the resistance of lymphomas to conventional therapy, and highlight the enormous promise of potential therapeutic strategies that could circumvent or overcome these genetic impediments to apoptosis.
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Rajani
R
Ravi
Atul
A
Bedi
D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D002470:Cell Survival; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007107:Immune System / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology*; D008223:Lymphoma / Q000188:drug therapy* / Q000503:physiopathology*; D008928:Mitochondria / Q000502:physiology; D015398:Signal Transduction