Solid-phase compound library synthesis in drug design and development.
This article is a subjective review of the literature between December 2000 and January 2002 related to the solid-phase synthesis of compound libraries for drug discovery and development. Examples of libraries yielding active compounds across a range of biological targets are presented, together with synthetic details where this is deemed of sufficient note. Background to the biological target and any structure-activity relationship, which can be discerned within members of a library series, is also discussed. A brief overview of new developments in solid-phase technology that is likely to impact upon drug discovery is also included.
Pfizer Global Research and Development, Library Design and Production Group, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK. paul_edwards@sandwich.pfizer.com
Paul J
PJ
Edwards
Andrew I
AI
Morrell
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D015195:Drug Design; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends