Molecular evidence for the role of a ferric reductase in iron transport.
Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.
Division of Life Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK. andrew.t.mckie@kcl.ac.uk
A T
AT
McKie
G O
GO
Latunde-Dada
S
S
Miret
J A
JA
McGregor
G J
GJ
Anderson
C D
CD
Vulpe
J M
JM
Wrigglesworth
R J
RJ
Simpson
D001692:Biological Transport; D002460:Cell Line; D002462:Cell Membrane / Q000201:enzymology; D018076:DNA, Complementary / Q000235:genetics; D004386:Duodenum; D038181:FMN Reductase / Q000235:genetics* / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology; D007501:Iron / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D018076:DNA, Complementary; D007501:Iron; D038181:FMN Reductase; C023903:ferric citrate iron reductase