Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage.
The antioxidant activity of an arabinogalactan polysaccharide (TSP) isolated from Tinospora cordifolia, an Indian medicinal plant, was studied. The polysaccharide showed good protection against iron-mediated lipid peroxidation of rat brain homogenate as revealed by the thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxide (LOOH) assays. TSP also provided significant protection to protein against gamma-ray induced damage. The protective action can possibly be explained by its very high reactivity towards DPPH, superoxide radicals and the most damaging of radicals, the hydroxyl radical.
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Mahesh
M
Subramanian
Gajanan J
GJ
Chintalwar
Subrata
S
Chattopadhyay
D000975:Antioxidants / Q000494:pharmacology*; D016166:Free Radical Scavengers; D005720:Gamma Rays; D006861:Hydrogen Peroxide; D007501:Iron / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000032:analysis; D011134:Polysaccharides / Q000494:pharmacology*; D011506:Proteins / Q000528:radiation effects*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D031610:Tinospora / Q000737:chemistry*
D000975:Antioxidants; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D011134:Polysaccharides; D011506:Proteins; D017392:Thiobarbituric Acid Reactive Substances; D006861:Hydrogen Peroxide; D007501:Iron