All signaling is local?
The mechanism of signal transmission following ligand stimulation of receptor tyrosine kinases in living cells is poorly understood. Recent studies have visualized the spatio-temporal pattern of EGF signaling, indicating that receptor density is an important factor in the mechanism of lateral propagation of local EGF signaling.
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.
Joseph
J
Schlessinger
D002467:Cell Nucleus / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D015398:Signal Transduction
D008024:Ligands; D004815:Epidermal Growth Factor; D066246:ErbB Receptors