[Effect of Boschniakia rossica extract on antioxidative activities in rat hepatic preneoplasia induced by diethylnitrosamine].
OBJECTIVE
To study the antioxidative effect of aqueous fraction of Boschniakia rossica(BR) extracted with methanol and fractionated with dichloromethane and water.


METHODS
Serum activities of superoxide dismutase(SOD), malondialdehyde(MDA), glutathione peroxidase (GSH-PX) and glutathione S-transferase (GST) were investigated in rat with preneoplasia induced by Solt-Farber protocol under administration with BR extract for 6 weeks.


RESULTS
Serum activities of SOD and GSH-PX rose again in rats administered with BR extract, and the increase of GST activity and content of MDA due to hepatic preneoplasia was decreased by the extract of BR, thus the pathological changes of tissues and cells can be reduced.


CONCLUSIONS
BR extract has antioxidative effect which may be a part of the antitumor mechanism of B. rossica.
Shen
M
M
Biochemistry Laboratory for Cancer Research, College of Medicine, Yanbian University, Yanji 133000.
Yin
Z
Z
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004052:Diethylnitrosamine; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood* / Q000139:chemically induced; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010946:Plants, Medicinal / Q000737:chemistry; D011230:Precancerous Conditions / Q000097:blood* / Q000139:chemically induced; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D004052:Diethylnitrosamine; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase