Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein.
The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections.
Martin
Denis
D
Unité de Recherche en Vaccinologie, Centre Hospitalier Universitaire de Québec et Université Laval, Ste-Foy, Canada. Denis.Martin@crchul.ulaval.ca
Rioux
Stéphane
S
Gagnon
Edith
E
Boyer
Martine
M
Hamel
Josée
J
Charland
Nathalie
N
Brodeur
Bernard R
BR
D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000008:administration & dosage; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology; D013290:Streptococcal Infections / Q000276:immunology* / Q000517:prevention & control*; D013292:Streptococcus agalactiae / Q000145:classification / Q000276:immunology*; D014611:Vaccination
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D011994:Recombinant Proteins; C414463:SIP protein, Streptococcus group B