[Beta-thromboglobulin concentration in chosen parasitic diseases].
Blood platelets are active elements in the body defense mechanisms, e.g. in antiparasitic immunology. A platelet stimulation may result from a direct contact with a parasite, increased IgG and/or IgE concentrations, the presence of complement, CRP or lymphokins. This study was aimed at establishing whether a parasitic infection could induce a platelet activation. The study involved 35 patients (30 patients were infected with Giardia intestinalis and 5 patients with Echinococcus granulosus). Blood for analysis was collected twice--before treatment (A1) and after treatment (A2). The concentrations of beta-thromboglobulin were assayed by means of the set of ASSERA-CHROM, according to the immuno-enzymatic method with labelled antibodies. The platelet count was determined with a haematologic analyser. Although platelets do not get into a direct contact with the parasite, an increase in the concentration of b-thromboglobulin is observed, and it may indicate the involvement of platelets in the parasitic disease.
Matowicka-Karna
Joanna
J
Zakład Laboratoryjnej Diagnostyki Klinicznej, Akademii Medycznej w Białymstoku.
Kemona
Halina
H
D000328:Adult; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000276:immunology*; D016022:Case-Control Studies; D004443:Echinococcosis / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016829:Giardia lamblia / Q000276:immunology*; D005873:Giardiasis / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D013997:Time Factors; D001620:beta-Thromboglobulin / Q000378:metabolism*
D000977:Antiparasitic Agents; D001620:beta-Thromboglobulin