Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae.
On the basis of functional and phylogenetic criteria, we have identified a total of 229 subfamilies and 111 singletons predicted to carry out transport or other membrane functions in Saccharomyces cerevisiae. We have extended the Transporter Classification (TC) and created a Membrane Classification (MC) for non-transporter membrane proteins. Using the preliminary phylogenetic digits X, Y, Z (for new families, subfamilies, and clusters, respectively), we allocated a five-digit number to 850 proteins predicted to contain more than two transmembrane domains. Compared with a previous TC of the yeast genome, we classified an additional set of 538 membrane proteins (transporters and non-transporters) and identified 111 novel phylogenetic subfamilies.
De Hertogh
Benoît
B
Unité de Génétique, Faculté d'Agronomie, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Carvajal
Elvira
E
Talla
Emmanuel
E
Dujon
Bernard
B
Baret
Philippe
P
Goffeau
André
A
D008565:Membrane Proteins / Q000145:classification* / Q000378:metabolism; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000145:classification* / Q000378:metabolism
D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins