Recent advances in chemical library synthesis methodology.
The first part of this review highlights recent advances in polymer-supported reagents, catalysts, reactants and sequestrants. Particular attention is given to recent advances in polymer-supported oxidants, transition metal catalysts and polymer-supported reactants, including acyl groups, guanidinyl groups, alkyl groups and various classes of nucleophiles. This second part of the review highlights recent advances made in the areas of chemical tagging and phase-trafficking techniques, all of which have enabled further advances in the methodology of solution-phase chemical library synthesis.
Flynn
Daniel L
DL
NeoGenesis Pharmaceuticals Inc, 840 Memorial Drive, Cambridge, MA 02139, USA. dflynn@neogenesis.com
Berk
Scott C
SC
Makara
Gergely M
GM
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods / Q000639:trends*; D006801:Humans; D011108:Polymers / Q000138:chemical synthesis; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends
D011108:Polymers