Synthesis of functionalized 1,5-cyclooctadienes by LICKOR metalation.
1,5-Cyclooctadiene was lithiated under LICKOR superbase conditions followed by reaction with alkyl halides or ethylene oxide to yield 3-substituted 1,5-cyclooctadienes in high yield and purity. This procedure is suitable for preparation of 1,5-cyclooctadienes carrying pendant functional groups for immobilization on solid-phase resins.
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Jefferson D
JD
Revell
A
A
Ganesan