Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.
Four new naphthylisoquinoline alkaloids, ancistrocongolines A-D (4-7) were isolated from Ancistrocladus congolensis, along with the known compound korupensamine A (8). Structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Their biological activities against the pathogens of malaria, Leishmaniasis, Chagas disease, and African sleeping sickness were evaluated.
Bringmann
Gerhard
G
Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
Messer
Kim
K
Brun
Reto
R
Mudogo
Virima
V
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003223:Congo; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D009132:Muscles / Q000166:cytology / Q000187:drug effects; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D013237:Stereoisomerism; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
D000470:Alkaloids; D000962:Antimalarials; D000981:Antiprotozoal Agents; D007546:Isoquinolines; D009281:Naphthalenes; D014344:Trypanocidal Agents; C110657:korupensamine A