Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants.
4-Hydroxyphenylacetic acid amides and 4-hydroxycinnamamides were synthesized and their antioxidant and neuroprotective activities were evaluated. Among the prepared compounds, 8b, and exhibited potent inhibition of lipid peroxidation in rat brain homogenates, and marked DPPH radical scavenging activities. Furthermore, and exhibited neuroprotective action against the oxidative damage induced by the exposure of primary cultured rat cortical cells to H(2)O(2), xanthine/xanthine oxidase, or Fe(2+)/ascorbic acid. Based on these results, we found that was the most potent antioxidant among the compounds tested.
Jung
Young-Sik
YS
Medicinal Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-606, Republic of Korea.
Kang
Tae-Souk
TS
Yoon
Joong-Ho
JH
Joe
Bo-Young
BY
Lim
Hee-Jong
HJ
Seong
Churl-Min
CM
Park
Woo-Kyu
WK
Kong
Jae-Yang
JY
Cho
Jungsook
J
Park
No-Sang
NS
D000577:Amides / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011422:Propionates; D051381:Rats
D000577:Amides; D000975:Antioxidants; D003373:Coumaric Acids; D010648:Phenylacetates; D011422:Propionates; C008070:4-hydroxyphenylacetic acid; C495469:p-coumaric acid