Corticotropin-releasing hormone receptors.
Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors.
Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. EHillhouse@bio.warwick.ac.uk
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Hillhouse
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Randeva
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Ladds
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Grammatopoulos
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism; D015398:Signal Transduction
D018019:Receptors, Corticotropin-Releasing Hormone; D011994:Recombinant Proteins; D019204:GTP-Binding Proteins