Hemorrhagic shock.
OBJECTIVE
To review the clinical aspects of hemorrhagic shock and provide recommendations for therapy.


METHODS
Early recognition of hemorrhagic shock and prompt systematic intervention will help avoid poor outcomes.


RESULTS
Establish guidelines to assist in early recognition of hemorrhagic shock and to conduct resuscitation in an organized and evidence-based manner.


METHODS
Medline references were sought using the MeSH term "hemorrhagic shock." All articles published in the disciplines of obstetrics and gynaecology, surgery, trauma, critical care, anesthesia, pharmacology, and hematology between 1 January 1990 and 31 August 2000 were reviewed, as well as core textbooks from these fields. Selected references from these articles and book chapters were also obtained and reviewed. The level of evidence has been determined using the criteria described by the Canadian Task Force on the Periodic Health Examination.


CONCLUSIONS
1. Clinicians should be familiar with the clinical signs of hemorrhagic shock. (III-B) 2. Clinicians should be familiar with the stages of hemorrhagic shock. (III-B) 3. Clinicians should assess each woman's risk for hemorrhagic shock and prepare for the procedure accordingly. (III-B) 4. Resuscitation from hemorrhagic shock should include adequate oxygenation. (II-3A) 5. Resuscitation from hemorrhagic shock should include restoration of circulating volume by placement of two large-bore IVs, and rapid infusion of a balanced crystalloid solution. (I-A) 6. Isotonic crystalloid or colloid solutions can be used for volume replacement in hemorrhagic shock (I-B). There is no place for hypotonic dextrose solutions in the management of hemorrhagic shock (I-E). 7. Blood component transfusion is indicated when deficiencies have been documented by clinical assessment or hematological investigations (II-2B). They should be warmed and infused through filtered lines with normal saline, free of additives and drugs (II-3B). 8. Vasoactive agents are rarely indicated in the management of hemorrhagic shock and should be considered only when volume replacement is complete, hemorrhage is arrested, and hypotension continues. They should be administered in a critical care setting with the assistance of a multidisciplinary team. (III-B) 9. Appropriate resuscitation requires ongoing evaluation of response to therapy, including clinical evaluation, and hematological, biochemical, and metabolic assessments. (III-B) 10. In hemorrhagic shock, prompt recognition and arrest of the source of hemorrhage, while implementing resuscitative measures, is recommended. (III-B)VALIDATION: These guidelines have been reviewed by the Clinical Practice Obstetrics Committee and approved by Executive and Council of the Society of Obstetricians and Gynaecologists of Canada.


BACKGROUND
The Society of Obstetricians and Gynaecologists of Canada.
Martel
Marie-Jocelyne
MJ
MacKinnon
Katherine Jane
KJ
Arsenault
Marc-Yvon
MY
Bartellas
Elias
E
Klein
Michael C
MC
Lane
Carolyn A
CA
Sprague
Ann E
AE
Wilson
Ann Kathleen
AK
D001803:Blood Transfusion / Q000379:methods / Q000592:standards; D019317:Evidence-Based Medicine; D005260:Female; D005440:Fluid Therapy / Q000379:methods / Q000592:standards; D006176:Gynecology / Q000379:methods* / Q000592:standards; D006801:Humans; D009774:Obstetrics / Q000379:methods* / Q000592:standards; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D012107:Research Design; D012151:Resuscitation / Q000379:methods* / Q000592:standards; D012307:Risk Factors; D012771:Shock, Hemorrhagic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*