Yersinia high-pathogenicity island contributes to virulence in Escherichia coli causing extraintestinal infections.
The Yersinia high-pathogenicity island (HPI) encodes an iron uptake system mediated by the siderophore yersiniabactin (Ybt) and confers the virulence of highly pathogenic Yersinia species. This HPI is also widely distributed in human pathogenic members of the family of Enterobacteriaceae, above all in extraintestinal pathogenic Escherichia coli (ExPEC). In the present study we demonstrate a highly significant correlation of a functional HPI and extraintestinal virulence in E. coli. Moreover, using a mouse infection model, we show for the first time that the HPI contributes to the virulence of ExPEC.
Schubert
Sören
S
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany. schubert@pk-i.med.uni-muenchen.de
Picard
Bertrand
B
Gouriou
Stéphanie
S
Heesemann
Jürgen
J
Denamur
Erick
E
D000818:Animals; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000209:etiology* / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D007501:Iron / Q000378:metabolism; D051379:Mice; D010636:Phenols; D017262:Siderophores / Q000235:genetics / Q000378:metabolism; D013844:Thiazoles; D014774:Virulence / Q000235:genetics; D015007:Yersinia / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity*
D010636:Phenols; D017262:Siderophores; D013844:Thiazoles; C104398:yersiniabactin; D007501:Iron