The effects of benzodiazepines on event-related potential indices of automatic and controlled processing in schizophrenia: a preliminary report.
The effects of benzodiazepines on cognitive function in schizophrenic patients were investigated using event-related potential (ERP) measurement during an auditory selective attention task. In this study, the authors compared the mismatch negativity (MMN) and N2b components between two subgroups of schizophrenic patients: one is comprised of patients who received no benzodiazepines (NT group, n = 7) and the other is comprised of those administered benzodiazepines in the daytime (T group, n = 7). There were no significant differences in MMN and N2b amplitudes between the two subgroups, whereas the N2b latency was significantly prolonged in the T group relative to the NT group. This suggested that benzodiazepines induce delayed stimulus classification processing in schizophrenic patients.
Murakami
Tadashi
T
Department of Neuropsychiatry, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Nakagome
Kazuyuki
K
Kamio
Satoru
S
Kasai
Kiyoto
K
Iwanami
Akira
A
Hiramatsu
Ken-Ichi
K
Fukuda
Masato
M
Hata
Akinobu
A
Honda
Makoto
M
Watanabe
Akira
A
Kato
Nobumasa
N
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001569:Benzodiazepines / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D018709:Statistics, Nonparametric
D001569:Benzodiazepines