[Activity of cytochrome P-450 aromatase, nitric oxide synthase and level of S-nitrosothiols in rat ovaries and uterus under oxidative stress caused by cobalt chloride].
Cytochrome P-450 aromatase and nitric oxide syntase activities were established to decrease in the ovaries and uteri of CoCl2 injected Wistar female rats. Respectively the S-nitrosothiols concentration was also decreased. The quantity of malonic dialdehyde was increased in the ovaries and uteri of rats injected by CoCl2. It's assumed that reactive oxygen species formed by CoCl2 inhibit the activities of aromatase and nitric oxide syntase as haem ligands and inhibitors of it's biosynthesis.
Iasinskaia
I M
IM
Mechnikov Odessa National University, Ukraine.
Rozanov
A Ia
AIa
D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D003035:Cobalt / Q000494:pharmacology*; D005260:Female; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D026403:S-Nitrosothiols / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D026403:S-Nitrosothiols; D003035:Cobalt; D019001:Nitric Oxide Synthase; D001141:Aromatase; C018021:cobaltous chloride