Pathophysiology, signs, and symptoms of acute tumor lysis syndrome.
OBJECTIVE
To provide a review of the pathophysiology and corresponding signs and symptoms of tumor lysis syndrome (TLS); to review clinical and laboratory monitoring parameters.


METHODS
Primary and tertiary literature and clinical experience.


CONCLUSIONS
An understanding of the pathophysiology of TLS, meticulous assessment for signs and symptoms and monitoring of laboratory data, as well as early recognition of problems are essential for optimal patient outcomes.


CONCLUSIONS
Knowledge of the pathophysiology of TLS will assist the oncology nurse in better understanding the overall syndrome and allow improved patient care management through close clinical and laboratory monitoring of signs and symptoms, and, ideally, promote a proactive approach to managing TLS.
Nell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Rd, Atlanta, GA 30322-4207, USA.
Roberta
R
Kaplow
D000208:Acute Disease; D003937:Diagnosis, Differential; D006801:Humans; D008659:Metabolic Diseases / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D009859:Oncology Nursing / Q000379:methods*; D015275:Tumor Lysis Syndrome / Q000150:complications / Q000451:nursing / Q000503:physiopathology