Voltammetric determination of fenbendazole in veterinarian formulations.
A versatile voltammetric method for quantitative determination of fenbendazole (FBZ) in commercial tablets has been proposed, where direct dissolution of tablets is carried out in 0.1 mol l(-1) tetrabutylamoniun tetrafluorborate containing dimethylformamide solutions. Linear sweep (LSV), square wave (SWV) and differential pulse (DPV) voltammetry techniques were applied to study FBZ at a glassy carbon electrode, exhibiting a well defined irreversible oxidation peak at 1.15 V vs. SCE. This methodology allows a precise quantitative determination of FBZ presenting detection limits of 5.2 x 10(-5) (LSV), 5.0 x 10(-6) (DPV) and 5.0 x 10(-5) mol l(-1) (SWV).
Instituto de Química, UNESP, 14801-970 Araraquara, SP, Brazil. marcelex@posgrad.iq.unesp.br
Marcelo Firmino
MF
de Oliveira
Nelson Ramos
NR
Stradiotto
D004563:Electrochemistry; D005273:Fenbendazole / Q000032:analysis* / Q000737:chemistry; D019155:Veterinary Drugs / Q000032:analysis / Q000737:chemistry
D019155:Veterinary Drugs; D005273:Fenbendazole