Brain repair by endogenous progenitors.
Stem cells within the adult brain can be stimulated by injury and growth factor treatment to replace damaged neurons, even neurons that are not normally generated in adults. Coupled with recent insights into the mechanism by which Nogo inhibits axonal regeneration, this discovery may inspire new treatments for central nervous system injuries and neurodegenerative diseases.
Kruger
Genevieve M
GM
Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA.
Morrison
Sean J
SJ
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development* / Q000293:injuries*; D002493:Central Nervous System Diseases / Q000628:therapy*; D006133:Growth Substances / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009185:Myelin Proteins / Q000187:drug effects / Q000378:metabolism; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D006133:Growth Substances; D009185:Myelin Proteins