Contribution of Candida albicans ALS1 to the pathogenesis of experimental oropharyngeal candidiasis.
We investigated the contribution of Candida albicans ALS1, which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection.
Kamai
Yasuki
Y
Biological Research Laboratory, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan. ykamai@shina.sankyo.co.jp
Kubota
Mikie
M
Kamai
Yoko
Y
Hosokawa
Tsunemichi
T
Fukuoka
Takashi
T
Filler
Scott G
SG
D000818:Animals; D002176:Candida albicans / Q000235:genetics* / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D002448:Cell Adhesion / Q000235:genetics / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics* / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D009154:Mutation; D014059:Tongue / Q000382:microbiology; D014774:Virulence / Q000235:genetics / Q000502:physiology
C093538:ALS1 protein, Candida albicans; D005656:Fungal Proteins