Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer.
A boron-rich, water-soluble porphyrin conjugate was synthesized by coupling of two carboranyl alcohols with 2-chlorophenoxyphosphorus dichloride, followed by conjugation to an amine-functionalized tetraphenyl-porphyrin via an amide linkage.
Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.
Andreas
A
Maderna
Ramon
R
Huertas
M Frederick
MF
Hawthorne
Raymond
R
Luguya
M Graça H
MG
Vicente
D001896:Boron Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy; D005453:Fluorescence; D010755:Organophosphates / Q000138:chemical synthesis* / Q000627:therapeutic use; D011166:Porphyrins; D012995:Solubility
D001896:Boron Compounds; D010755:Organophosphates; D011166:Porphyrins