Molecular biology of blood pressure regulatory genes.
Blood pressure is determined by vascular resistance and circulating volume. Activation of vascular angiotensin II or thromboxane receptor is mostly involved in the former, and function of renal prostagalandin EP3 receptor or thiazide-sensitive sodium-chloride co-transporter is also in the latter. We have cloned rat genes for these blood pressure regulatory factors, and studied their gene expression. Here we review the molecular biology of those genes, based on our observations.
Takeuchi
Kazuhisa
K
Division of Nephrology, Endocrinology, and Vascular Biology, Tohoku University Graduate School of Medicine, Sendai, Japan. hek293@mail.cc.tohoku.ac.jp
D000804:Angiotensin II / Q000235:genetics; D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D005809:Genes, Regulator; D005819:Genetic Markers; D006973:Hypertension / Q000235:genetics*; D008967:Molecular Biology; D011379:Prognosis; D051381:Rats; D011945:Receptors, Angiotensin / Q000235:genetics*; D018078:Receptors, Prostaglandin E / Q000235:genetics*; D017482:Receptors, Thromboxane / Q000235:genetics*; D012680:Sensitivity and Specificity; D014655:Vascular Resistance
D005819:Genetic Markers; D011945:Receptors, Angiotensin; D018078:Receptors, Prostaglandin E; D017482:Receptors, Thromboxane; D000804:Angiotensin II