Battle for the bulge: directing small molecules to DNA and RNA defects.
Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.
Department of Chemistry, Pennsylvania State University, 152 Davey Laboratory, University Park 16802, USA.
Philip C
PC
Bevilacqua
D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D015195:Drug Design; D008024:Ligands; D009690:Nucleic Acid Conformation / Q000187:drug effects; D012313:RNA / Q000737:chemistry* / Q000187:drug effects
D008024:Ligands; D012313:RNA; D004247:DNA