Synthesis and cytotoxic activity of pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents.
Several new pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives were synthesised from beta-carboline derivatives and their cytotoxic activity and effect on the cell cycle were evaluated against L1210 cancer cells.
Departamento de Qui;mica Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.
Alberto
A
Fontana
Enrique J
EJ
Benito
M Justina
MJ
Martín
Nuria
N
Sánchez
Ramón
R
Alajarín
J José
JJ
Vaquero
Julio
J
Alvarez-Builla
Stéphanie
S
Lambel-Giraudet
Stéphane
S
Leonce
Alain
A
Pierré
Daniel
D
Caignard
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles