Thrombocytosis associated with enzyme replacement therapy in Gaucher disease.
We describe a patient with an intact spleen and moderately severe symptoms of Gaucher disease in whom, after initiation of (low-dose) enzyme replacement therapy (ERT), thrombocytosis (720 x 10(9)/l) was documented. Checking the International Gaucher Registry database revealed that this patient is the only nonsplenectomized patient of more than 1,000 treated patients to experience ERT-induced thrombocytosis. Platelet counts dropped immediately after the discontinuation of ERT.
Dweck
Altoon
A
Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel.
Blickstein
Dorit
D
Elstein
Deborah
D
Zimran
Ari
A
D000328:Adult; D057487:Enzyme Therapy; D004798:Enzymes / Q000009:adverse effects; D005260:Female; D005776:Gaucher Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D010976:Platelet Count; D013154:Spleen; D013922:Thrombocytosis / Q000139:chemically induced*
D004798:Enzymes