Effect of CaF2 on densification and properties of hydroxyapatite-zirconia composites for biomedical applications.
Hydroxyapatite (HA) composites with zirconia (ZrO2) up to 40 vol% were fabricated with the addition of CaF2. The sinterability of the composites was found to be enhanced markedly by the addition of small amounts of CaF2 (< 5 vol%). Decomposition of HA to beta-TCP was suppressed due to the substitution of F- for OH-, consequently forming fluor-hydroxyapatite (FHA) solid solution. This suppression of decomposition allowed the production of a fully dense body, which retained both high flexural strength and fracture toughness. The osteoblast-like cell (MG63) response to these F- ion-containing composites displayed comparable cell viability to pure-HA by in vitro proliferation test.
Kim
Hae-Won
HW
School of Materials Science and Engineering, Seoul National University, South Korea.
Noh
Yoon-Jung
YJ
Koh
Young-Hag
YH
Kim
Hyoun-Ee
HE
Kim
Hyun-Man
HM
D001672:Biocompatible Materials; D002124:Calcium Fluoride / Q000737:chemistry*; D002455:Cell Division; D002460:Cell Line; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology; D015040:Zirconium / Q000737:chemistry*
D001672:Biocompatible Materials; D017886:Durapatite; D015040:Zirconium; D002124:Calcium Fluoride; C028541:zirconium oxide