[Expression of C-erbB-2 protein in breast cancer and its clinical significance].
In order to understand the expression of C-erbB-2 protein in breast cancer and its clinical significance, we examined the expression of C-erbB-2 protein in 106 breast carcinomas by using the immunohistochemical techniques LSAB. The results showed that the positive rate of C-erbB-2 expression was 63.21% (67/106). The overexpression of C-erbB-2 protein related negatively with survival. 81.63% of the cases with overexpression of C-erbB-2 protein survived < or = 5 years and 34.29% survived > 10 years. There were significant associations of C-erbB-2 overexpression with advanced clinical stage, high histological grade, and positive axillary node status in breast cancers. All of these findings suggested that overexpression of C-erbB-2 protein might be an important prognostic factor and the detection of C-erbB-2 protein might be arranged as a regular pathological examination in the cases of breast cancer.
Department of General Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041.
J
J
Yang
T
T
Xing
R
R
Hu
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics
D018719:Erb-b2 Receptor Tyrosine Kinases