Numb: "Adapting" notch for endocytosis.
During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell, Berdnik et al. show that Numb recruits alpha-Adaptin and that this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch.
Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Houston, TX 77030, USA.
Hamed
H
Jafar-Nejad
Koenraad
K
Norga
Hugo
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Bellen
D000818:Animals; D033965:Adaptor Protein Complex alpha Subunits; D019521:Body Patterning / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D029721:Drosophila Proteins; D004705:Endocytosis / Q000502:physiology; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D051880:Receptors, Notch; D012679:Sense Organs / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
D033965:Adaptor Protein Complex alpha Subunits; D002352:Carrier Proteins; D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008565:Membrane Proteins; C497759:N protein, Drosophila; C060606:numb protein, Drosophila; D051880:Receptors, Notch
Non-programmatic