Evaluation of pulse corticosteroid therapy for vogt-koyanagi-harada disease assessed by optical coherence tomography.
OBJECTIVE
To evaluate the rapid effects of pulse corticosteroid therapy on the serous retinal detachment found at the acute phase of Vogt-Koyanagi-Harada disease.


METHODS
Interventional case series.


METHODS
Nine Japanese patients determined to be at the acute phase of Vogt-Koyanagi-Harada disease with serous retinal detachment were treated with pulse corticosteroid therapy. Optical coherence tomography was used to follow the resolution of the retinal detachment.


RESULTS
Optical coherence tomography images showed a marked decrease in the retinal detachment immediately after the first intravenous injection of corticosteroid and subsequent resolution.


CONCLUSIONS
The rapid improvement of serous retinal detachment associated with Vogt-Koyanagi-Harada disease following pulse corticosteroid therapy supports an early therapeutic mechanism related to improved permeability of capillaries and permeability of the blood-retinal barrier rather than an anti-inflammatory or immunosuppressive action.
Department of Ophthalmology, Osaka University Medical School, Japan.
Emiko
E
Yamanaka
Nobuyuki
N
Ohguro
Shuji
S
Yamamoto
Yayoi
Y
Nakagawa
Yoshiko
Y
Imoto
Yasuo
Y
Tano
D000208:Acute Disease; D003941:Diagnostic Techniques, Ophthalmological; D004341:Drug Evaluation; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D007368:Interferometry; D008027:Light; D008775:Methylprednisolone / Q000627:therapeutic use*; D020551:Pulse Therapy, Drug; D012163:Retinal Detachment / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014054:Tomography; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D005938:Glucocorticoids; D008775:Methylprednisolone