Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies.
The two experimental designs (quantal and bracketing) used for population minimum alveolar anesthetic concentration studies give equivalent results. An expression relating variability in terms of Hill coefficients and SD is presented. Evolutionary implications of low population variability in anesthetic phenotypes is discussed.
Department of Anesthesia and Perioperative Care, Room S-455i, Box 0464, University of California, San Francisco, CA 94143-0464, USA. sonnerj@anesthesia.ucsf.edu
James M
JM
Sonner
D000465:Algorithms; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D003627:Data Interpretation, Statistical; D000077335:Desflurane; D007530:Isoflurane / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D016011:Normal Distribution; D010147:Pain Measurement / Q000187:drug effects; D010597:Pharmacogenetics; D011153:Population; D011650:Pulmonary Alveoli / Q000378:metabolism*; D012044:Regression Analysis; D012107:Research Design
D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane