[A case of follicular lymphoma derived from the conjunctiva].
BACKGROUND
Follicular lymphoma, derived from ocular adnexa as defined by World Health Organization Classification of neoplastic diseases of the hematopoietic and lymphoid tissues, is quite rare in Japan.


METHODS
A 65-year-old woman visited our clinic for treatment of a conjunctival tumor in the left eye.


RESULTS
Incisional biopsy revealed that the lesion was a lymphoma with well-defined follicles, and it was L 26(CD20) and BCL-2 positive immunohistochemically. Flow cytometric analysis showed that more than 70% of the cells were double positive for CD10 and CD20. Southern blot hybridization demonstrated gene rearrangement bands in the immunoglobulin gene JH region. The chromosome had a translocation t(14, 18) (q32, q21). Systemic evaluation detected no other lymphoma.


CONCLUSIONS
The lesion was a follicular lymphoma derived from conjunctival tissue. Additional examinations such as flow cytometric analysis, gene analysis, and chromosome examination were useful for differential diagnosis of marginal zone B cell lymphoma of mucosa associated lymphoid tissue type and benign reactive lymphoid hyperplasia.
Department of Ophthalmology, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Atsushi
A
Azumi
Koji
K
Hirai
Yasushi
Y
Tamura
Kazuko
K
Saito
Hiroyuki
H
Yamamoto
Akira
A
Negi
Chiho
C
Obayashi
D000368:Aged; D003228:Conjunctiva; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D015321:Gene Rearrangement; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology