Isotactic polymethoxydienes from the Philippines sponge Myriastra clavosa.
A specimen of the sponge Myriastra clavosa from the Philippines contained five new isotactic polymethoxydienes 1-5 that form a homologous series. The structures of the isotactic polymethoxydienes, which exhibited moderate cytotoxicity, were elucidated by interpretation of spectroscopic data.
Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093-0212, USA.
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Rama Rao
D John
DJ
Faulkner
D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D004987:Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000475:Alkenes; D000970:Antineoplastic Agents; D004987:Ethers; D011108:Polymers