[Effect of ethanol on intracellular Ca2+ metabolism].
The aim of this review is to summarize current thinking on ethanol effects on the Ca2+ homeostasis in the excitable tissue cells. It has been shown that acute exposure to ethanol decreases cytoplasmic Ca2+ concentration due to Ca2+ channels inhibition and Ca2+ pumps activation. Whereas chronic exposure to ethanol increases the intracellular Ca2+ concentration in cells due to activation of passive Ca2+ transport systems and inhibition of energy-dependent Ca2+ transport systems. The emphasis is place on a possible role of pharmacologic agents that preserve Ca2+ homeostasis in protecting against ethanol-induced diseases.
Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv.
L G
LG
Babich
S G
SG
Shlykov
L A
LA
Borisova
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D006706:Homeostasis
D015220:Calcium Channels; D000431:Ethanol; D000252:Calcium-Transporting ATPases; D002118:Calcium