Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives.
A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P3 . Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis.
Institut für Organische Chemie, Universität Bremen, UFT Leobener Strasse, 28359 Bremen, Germany.
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Dinkel
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Moody
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Traynor-Kaplan
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Schultz
cyclitols; cystic fibrosis; phosphoinositides; secretion; signal transduction