DNA oxidation by peroxo-chromium(v) species: oxidation of guanosine to guanidinohydantoin.
Reactions of peroxo-chromium(v) complexes with DNA afforded mainly guanine oxidation yielding, a four-electron oxidation product, guanidinohydantoin, and exhibited extensive base labile strand scission.
Joudah
Lamis
L
Department of Chemistry, Kent State University, Kent, OH 44242, USA.
Moghaddas
Shadi
S
Bose
Rathindra N
RN
D000080242:8-Hydroxy-2'-Deoxyguanosine; D002273:Carcinogens / Q000737:chemistry* / Q000494:pharmacology; D017608:Chromium Compounds / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry / Q000378:metabolism; D006151:Guanosine / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D016273:Occupational Exposure; D010084:Oxidation-Reduction
D002273:Carcinogens; D017608:Chromium Compounds; D006146:Guanidines; C417602:guanidinohydantion; D006151:Guanosine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D006861:Hydrogen Peroxide; D003849:Deoxyguanosine