[Effect of tian ma cu zhi chongji medicinal granules (TMCZCJ) on blood rheology in hypostasis rats due to stagnation of liver-qi and learning-memory disorder in cerebral ischemia-reperfusion mice].
OBJECTIVE
To investigate the effect of TMCZCJ on the blood rheology in hypostasis rats due to stagnation of the liver-qi and on the learning-memory disorder in cerebral ischemia-reperfusion mice.


METHODS
The models of hypostasis due to stagnation of the liver-qi were made by combining irritation with hypodemic injected adrenalin and ice-bath in rats, and the models of learning-memory disorder were made by repeatedly ligating-reperfusing the bilateral carotid in mice. The hypostasis rats and learning-memory disorder mice were perorally administrated TMCZCJ(7.7, 15.4 g.kg-1) once a day, for fourteen consecutive days.


RESULTS
TMCZCJ can significantly reduce plasma viscosity, blood viscosity and reduced viscosity in hypostasis rats. It can also improve the latent learning-memory capability and memory gain-repetition ability in water-maze for cerebral ischemia-reperfusion mice.


CONCLUSIONS
TMCZCJ can improve remarkably blood rheology in hypostasis rats and learning-memory disorder in cerebral ischemia-reperfusion mice.
Institute of Chinese Materia Medica, China Academy of TCM, Beijing 100700.
G
G
Du
Y
Y
Zhao
X
X
Wang
H
H
Cui
C
C
Cao
J
J
Fu
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D002545:Brain Ischemia / Q000523:psychology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018056:Hemorheology; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000523:psychology*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal