Transmission of Y chromosomal microdeletions from father to son through intracytoplasmic sperm injection.
We conducted chromosomal analysis of three male infants fathered by severe oligozoospermic males with Y chromosomal microdeletions through intracytoplasmic sperm injection (ICSI). Two of the infants had the same Y chromosomal microdeletions as their fathers. The third infant also had a Y chromosomal microdeletion, which was longer than that found in his father. The results confirm that Y chromosomal microdeletions are transmitted from a father to a son via ICSI and also suggest that the microdeletions may be expanded during such transmission. Genetic counseling for infertile couples contemplating ICSI is important if the male carries Y chromosomal microdeletions.
Laboratory of Developmental Biology and Reproduction, Institute for Advanced Medical Sciences, Hyogo, Japan. komor615@hyo-med.ac.jp
Shinji
S
Komori
Hiroshi
H
Kato
Shin-ichiro
S
Kobayashi
Koji
K
Koyama
Shinzo
S
Isojima
D003593:Cytoplasm; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D005307:Fertilization in Vitro; D017353:Gene Deletion; D008040:Genetic Linkage; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy; D007564:Japan; D008297:Male; D008845:Microinjections; D016133:Polymerase Chain Reaction; D013094:Spermatozoa / Q000502:physiology*; D014998:Y Chromosome / Q000235:genetics*
D017931:DNA Primers