Short-term omeprazole treatment does not influence biochemical parameters of bone turnover in children.
Gastric proton pump inhibitors are widely used in the treatment of dyspeptic problems and for the eradication of H. pylori infection. Data are not available on whether omeprazole, a representative of proton pump inhibitors, influences the function of osteoclastic H+-pump in children. We studied the impact of short-term omeprazole administration on the biochemical parameters of bone turnover in pediatric patients. Urinary calcium excretion, serum total alkaline phosphatase activity, collagen type 1 crosslinked C-telopeptide, and osteocalcin levels were determined in 34 children [20 girls (9 prepubertal) and 14 boys (6 prepubertal)] before and after 2 weeks of omeprazole treatment at a dose of 20 mg/day. The measured parameters were within the healthy reference range in each patient. None of them altered during the study in any age or in any gender. We conclude that omeprazole, at a dose of 20 mg/day, does not significantly influence the investigated biochemical parameters of osteoclast and osteoblast function in pediatric patients.
First Department of Pediatrics, Semmelweis University, Budapest Bókay u. 53, H-1083, Hungary. kopist@gyer1.sote.hu
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Kocsis
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Arató
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Bodánszky
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Szönyi
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Szabó
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Tulassay
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Vásárhelyi
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001862:Bone Resorption / Q000188:drug therapy*; D002118:Calcium / Q000652:urine; D002648:Child; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D015675:Osteocalcin / Q000097:blood; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology; D010455:Peptides / Q000652:urine; D012016:Reference Values
D000897:Anti-Ulcer Agents; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase; D009853:Omeprazole; D002118:Calcium