Chromosomal aberrations in peripheral lymphocytes of children as biomarkers of environmental exposure and life style.
The original purpose of our study was to determine if the detection of chromosomal aberrations in peripheral lymphocytes of children might be used as a biomarker of environmental pollution and life style. We compared the results of cytogenetic analyses performed in children and adolescents in the periods 1984-1993 and 1994-1999, in a total of 3402 subjects. The frequency of aberrant cells (AB.C.) markedly decreased in the period 1994-1999 compared with the period 1984-1993. The decreases in AB.C. were significant in the age groups 7-15 and 16-19 years: 1.63% AB.C. versus 1.14% AB.C. and 2.02% AB.C. versus 1.08% AB.C., respectively (P<0.01). No difference in the frequency of AB.C. was observed in newborns. Based on our experience, we believe that monitoring the spontaneous level of chromosomal aberrations in children over 5 year periods may be used to examine the general changes in environmental pollution in larger geographic areas.
Laboratory of Genetic Toxicology, National Institute of Public Health, Prague, Czech Republic. pavel.rossner@szu.cz
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D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D018153:Czech Republic; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008019:Life Style; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology; D008297:Male; D019216:Metals, Heavy / Q000032:analysis
D015415:Biomarkers; D019216:Metals, Heavy