Synthesis and antifungal and antioxidant properties of some new 5-substituted-4-amino(or aryl)-3-mercapto-4(H)-1,2,4-triazoles.
The synthesis and antifungal and antimicrobial evaluation of some new 5-substituted-4-amino(or aryl)-3-mercapto-4(H)-1,2,4-triazoles is reported. The involvement of the new compounds in free radical processes is also investigated and their lipophilicity is calculated and related to the determined antioxidant activity. Compounds 7a, 7b and 7c exhibited interesting antioxidant properties at concentration 0.01 mmol/l, expressed by their capacity to inhibit Fe2+/ascorbate induced hepatic microsomal lipid peroxidation, to scavenge OH.and to interact with nitrogen centered radicals such as 1,1-diphenyl-2-picrylhydrazyl stable free radical (DPPH). Moreover, compound 6a showed activity against Aspergillus versicolor, possessing a MIC of 82 micrograms/ml.
Marakos
Panagiotis
P
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Athens, Greece.
Papakonstantinou-Garoufalias
Spyroula
S
Tani
Ekaterini
E
Kourounakis
Panos N
PN
Athanasiou
George
G
Chytyroglou-Lada
Aikaterini
A
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D017665:Hydroxyl Radical / Q000737:chemistry; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016877:Oxidants / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D007202:Indicators and Reagents; D016877:Oxidants; D010851:Picrates; D013438:Sulfhydryl Compounds; D013844:Thiazoles; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl; D004121:Dimethyl Sulfoxide