[Morphofunctional organization of lymphoepithelial organs of the human pharynx].
We present the current concepts of morphofunctional organization of the lymphoepithelial organs in the human pharynx based on the published data and authors' results. Functional compartmentation of palatine and pharyngeal tonsils is considered, which reflects cooperative cell interactions in the immune response; B- and T-areas have been structurally isolated and functionally substantiated. A special attention is paid to the fine structure of cryptal epithelium and its interactions with lymphoid cells infiltrating the epithelial sheet: lymphoepithelial symbiosis. Attention is also paid to structural homology of the lymphoepithelial compartment of palatine tonsils and thymus. The problem concerns the place of lymphoepithelial organs in hierarchy of the immune system as secondary organs with their own immunoregulatory area and having the functions of a regional center controlling the mucosal immunity.
Research-Clinical Center of Otorhinolaryngology, Ministry of Health of Russian Federation, 2-i Botkinskii per. 5/14, Moscow, 125101 Russia.
V P
VP
Bykova
G P
GP
Satdykova
D004848:Epithelium / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D008221:Lymphoid Tissue / Q000033:anatomy & histology / Q000502:physiology; D010614:Pharynx / Q000033:anatomy & histology / Q000502:physiology*