Insights into antigen processing gained by direct analysis of the naturally processed class I MHC associated peptide repertoire.
MHC class I molecules are responsible for the presentation of antigenic peptides to CD8+ T lymphocytes. Based on their relatively promiscuous binding of peptides, these molecules display information derived from a large fraction of proteins that are made inside the cell. This review describes our characterization of the peptides comprising this repertoire, with particular attention given to their complexity and quantities, their post-translational modification, and the pathways leading to their expression.
Engelhard
Victor H
VH
Carter Immunology Center and Department of Microbiology, School of Medicine, University of Virginia, P.O. Box 801386, Charlottesville, VA 22908, USA. bhe@virginia.edu
Brickner
Anthony G
AG
Zarling
Angela L
AL
D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D003546:Cysteine Endopeptidases / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D015778:Minor Histocompatibility Antigens / Q000378:metabolism; D008969:Molecular Sequence Data; D014442:Monophenol Monooxygenase / Q000378:metabolism; D009097:Multienzyme Complexes / Q000502:physiology; D010455:Peptides / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D011499:Protein Processing, Post-Translational
D015395:Histocompatibility Antigens Class I; D015778:Minor Histocompatibility Antigens; D009097:Multienzyme Complexes; D010455:Peptides; D014442:Monophenol Monooxygenase; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex