Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome.
Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
R P
RP
Allen
E
E
Mignot
B
B
Ripley
S
S
Nishino
C J
CJ
Earley
D017668:Age of Onset; D000368:Aged; D002352:Carrier Proteins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D017286:Polysomnography; D012016:Reference Values; D012148:Restless Legs Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012720:Severity of Illness Index; D013997:Time Factors
D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins