Microdosimetric characteristics of the clinical proton beams at JINR, Dubna.
High-energy proton radiotherapy beams give rise to secondary heavy charged particles with elevated linear energy transfer (LET), which contribute to the dose in a patient. This contribution to the characteristics of radiotherapy proton beams was experimentally studied by means of a LET spectrometer based on a track detector. The spectrometer permits LET spectra to be established in the region above 10 keV.micron-1 in tissue. Sets of track detectors were exposed in the various depths of a phantom irradiated with protons of two energies, 150 and 205 MeV. It was observed that the contribution of particles with the values of LET mentioned increases with the depth, representing from about 2 (at the surface) up to few tens% close to Bragg peak region of the total dose. There, some of primary protons contribute also above 10 keV.micron-1. Using the 'biological weighted function' proposed, the clinical RBE was calculated, it could approach 1.3. This effect has to be taken into account during the clinical beam production and the radiotherapy.
Molokanov
A G
AG
Joint Institute of Nuclear Research (JINR), Dubna, Russia.
Bĕgusová
M
M
Spurný
F
F
Vlcek
B
B
D018499:Linear Energy Transfer; D011522:Protons; D011874:Radiometry / Q000379:methods; D012426:Russia; D012680:Sensitivity and Specificity; D013816:Thermodynamics
D011522:Protons