Two kinds of endometrial neoplasia arising from different origins in the uterine corpus: comparison of p53 expression and sex steroid receptor status.
This study presents a case of endometrial clear cell adenocarcinoma complicated by complex atypical glandular hyperplasia surrounded by adenomyosis in the uterine myometrium. The former was immuno-negative for estrogen receptor (ER) and positive for p53, whereas both of the latter were immuno-positive for ER and negative for p53. Therefore, there were two kinds of neoplasia arising from different origins in the uterine corpus.
Koshiyama
Masafumi
M
Department of Obstetrics and Gynecology, Himeji National Hospital, 68 Honmachi, Himeji, Hyogo 670-8520, Japan. kosiya@mb.infoweb.ne.jp
Ueta
Michio
M
D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry* / Q000150:complications / Q000473:pathology; D000368:Aged; D004714:Endometrial Hyperplasia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000150:complications / Q000473:pathology; D004715:Endometriosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D011960:Receptors, Estrogen; D016159:Tumor Suppressor Protein p53