Molecular evolution of FOXP2, a gene involved in speech and language.
Language is a uniquely human trait likely to have been a prerequisite for the development of human culture. The ability to develop articulate speech relies on capabilities, such as fine control of the larynx and mouth, that are absent in chimpanzees and other great apes. FOXP2 is the first gene relevant to the human ability to develop language. A point mutation in FOXP2 co-segregates with a disorder in a family in which half of the members have severe articulation difficulties accompanied by linguistic and grammatical impairment. This gene is disrupted by translocation in an unrelated individual who has a similar disorder. Thus, two functional copies of FOXP2 seem to be required for acquisition of normal spoken language. We sequenced the complementary DNAs that encode the FOXP2 protein in the chimpanzee, gorilla, orang-utan, rhesus macaque and mouse, and compared them with the human cDNA. We also investigated intraspecific variation of the human FOXP2 gene. Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution.
Enard
Wolfgang
W
Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D-04103 Leipzig, Germany.
Przeworski
Molly
M
Fisher
Simon E
SE
Lai
Cecilia S L
CS
Wiebe
Victor
V
Kitano
Takashi
T
Monaco
Anthony P
AP
Pääbo
Svante
S
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D051858:Forkhead Transcription Factors; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007802:Language; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D010802:Phylogeny; D011323:Primates / Q000235:genetics; D012641:Selection, Genetic; D013060:Speech; D013064:Speech Disorders / Q000235:genetics*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; D014157:Transcription Factors