[Susceptibility to antifungal agents of Cryptococcus species of clinical interest].
BACKGROUND
Studies on the susceptability of Cryptococcus species to antifungal agents are scarce.


METHODS
We investigate the susceptibility of 54 clinical and environmental strains from six different species using the Sensititre and the NCCLS methods.


RESULTS
Environmental strains were less susceptible than clinical strains. We found MICs >= 64 mg/l for fluconazole, MICs >= 1 mg/l for itraconazole and MICs >= 32 mg/l for 5-fluorocytosine in C. albidus, C. neoformans and C. uniguttulatus.


CONCLUSIONS
These findings point at the importance of determining the antifungal susceptibility of Cryptococcus species.
Hospital Universitario Puerta del Mar, Cádiz, Spain. mcaicoya@hmn.es
Pedro
P
García-Martos
Juan Francisco
JF
Noval
Ana
A
García-Tapia
Pilar
P
Marín
José Luis
JL
Puerto
Antonio
A
Sepúlveda
D000935:Antifungal Agents / Q000627:therapeutic use*; D003124:Colorimetry; D003453:Cryptococcosis / Q000188:drug therapy* / Q000235:genetics* / Q000382:microbiology; D015725:Fluconazole / Q000627:therapeutic use*; D020022:Genetic Predisposition to Disease; D006801:Humans
D000935:Antifungal Agents; D015725:Fluconazole