Isotactic polymethoxydienes from the Philippines sponge Myriastra clavosa.
A specimen of the sponge Myriastra clavosa from the Philippines contained five new isotactic polymethoxydienes 1-5 that form a homologous series. The structures of the isotactic polymethoxydienes, which exhibited moderate cytotoxicity, were elucidated by interpretation of spectroscopic data.
Rama Rao
M
M
Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093-0212, USA.
Faulkner
D John
DJ
D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D004987:Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000475:Alkenes; D000970:Antineoplastic Agents; D004987:Ethers; D011108:Polymers