Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. The application of Epitalon in Campbell rats is found to intensify the bioelectric and functional activity of the retina due to the preservation of its morphological structure. Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. The analysis of Epitalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina.
Khavinson
Vladimir
V
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Branch of the Russian Academy of Medical Sciences, 3 Dynamo Project, 197110 St. Petersburg, Russia. ibg@medport.ru
Razumovsky
Michael
M
Trofimova
Svetlana
S
Grigorian
Roman
R
Razumovskaya
Anna
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D004553:Electric Conductivity; D004596:Electroretinography; D006801:Humans; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage*; D010870:Pineal Gland / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000473:pathology / Q000502:physiology; D012174:Retinitis Pigmentosa / Q000188:drug therapy* / Q000473:pathology
D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine