[Concentration of sVAP in serum of patients with different forms of Lyme borreliosis].
OBJECTIVE
The aim of our work was to assess the serum concentration of soluble VAP-1 (sVAP-1) in patients with arthral type of borreliosis and erythema migrans.


METHODS
We included in our study 30 patients in the age of 17-53 years who were treated for erythema migrans and 30 patients in the age of 25-63 years who were diagnosed with arthral type of borreliosis. The control group consisted of 30 healthy blood donors. The diagnosis of borreliosis was made on the basis of anamnesis, physical examination and additional tests, one of which proved the existence of IgM and IgG antibodies against Borrelia burgdorferi antigen present in the serum of patients. All samples for investigations were taken in a single collection manner. The serum concentration of sVAP-1 protein was assessed with ELISA method. All data were analysed statistically. We assumed 5% risk of conclusion error.


CONCLUSIONS
1. We did not observe an increase in serum sVAP-1 concentration in patients with erythema migrans compared to the control group. All observed differences in the serum level of this protein seemed to be random ones. 2. We showed a statistically important increase in soluble sVAP-1 serum concentration in patients with arthral type of borreliosis compared to the control group.
Katedra i Klinika Chorób Zakaźnych A.M. w Lublinie.
Hanna
H
Fota-Markowska
Roma
R
Modrzewska
Dariusz
D
Bielec
Joanna
J
Lis
Anna
A
Przbyła
D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D000907:Antibodies, Bacterial / Q000097:blood; D001170:Arthritis, Infectious / Q000097:blood* / Q000382:microbiology*; D025065:Borrelia burgdorferi / Q000276:immunology; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D015787:Erythema Chronicum Migrans / Q000097:blood*; D005260:Female; D016468:Forestry; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged
D000907:Antibodies, Bacterial; D015815:Cell Adhesion Molecules; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)