[A study on characteristics of transdermal absorption of Radix Angelieae Sinensis and its compound formula].
OBJECTIVE
To investigate the characteristics of transdermal absorption of Radix Angelieae Sinensis and its compound formula.


METHODS
Using Valia-Chien diffusion cell in vitro, and HPLC to determine the content of ferulic acid(FA).


RESULTS
The transdermal permeability coefficient (PC)pf FA, which is the main ingredient of Radix Angelieae Sinensis, is greater than that of the monomer (P < 0.01): the PC of FA is decreased when Radix Angelieae Sinensis and Salviae Miltiorrhizae are used together (P < 0.01): borneol helps enhance the permeation of Radix Angelisas Sinensis (P < 0.01); the PC of the compound formula is greater than that of the compatibility (P < 0.01).


CONCLUSIONS
The transdermal absorption of an ingredient of a traditional Chinese drug is affected not by compatibility, but also by other ingredients of the drug. The transdermal absorption of a monomer or a single drug could not fully mirror the absorption of a compound formula.
Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China.
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D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D003373:Coumaric Acids / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012869:Skin Absorption
D003373:Coumaric Acids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C004999:ferulic acid