Expression of p27(Kip1) in bladder cancers: immunohistochemical study and prognostic value in a series of 95 cases.
Prognostic value of p27(Kip1) immunohistochemical expression was evaluated in a series of 95 bladder carcinomas. Low p27(Kip1) expression was correlated with higher tumor grade (P=0.01) and stage (P=0.009), associated with poor overall survival (P=0.01) and, for superficial cancers, with disease-free survival (P=0.05). Thirty-five cases exhibited a heterogeneous expression related in some instances to tumoral architecture. Seventeen cases showed a cytoplasmic reactivity related to low nuclear expression (P=0.057). Loss of p27(Kip1) expression is a pejorative event in bladder tumors and inhibition of p27(Kip1) degradation could offer new therapeutic ways.
Department of Pathology, CHU Rangueil, 31403 Toulouse Cedex 4, France.
Laetitia
L
Lacoste-Collin
Anne
A
Gomez-Brouchet
Ghislaine
G
Escourrou
Marie-Bernadette
MB
Delisle
Thierry
T
Levade
Emmanuelle
E
Uro-Coste
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018797:Cell Cycle Proteins / Q000032:analysis*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D025521:Tumor Suppressor Proteins / Q000032:analysis*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology
D018797:Cell Cycle Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27