The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development.
The Drosophila C(2)-H(2)-type zinc-finger transcription factor CF2 has been shown to regulate follicular cell fate determination during oogenesis. Here we show that CF2 is also expressed in the developing muscles of the embryo where it first appears at stage 12 at the time of skeletal myoblast fusion. Later it is expressed in all muscle lineages including skeletal, visceral and cardiac. Epistatic analysis showed that CF2 expression is dependent on the myogenic factor MEF2.
European Molecular Biology Laboratory, Heidelberg, D-69117, Germany. bagni@uniroma2.it
Claudia
C
Bagni
Sarah
S
Bray
Joseph A
JA
Gogos
Fotis C
FC
Kafatos
Tien
T
Hsu
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000196:embryology* / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D007150:Immunohistochemistry; D064326:MEF2 Transcription Factors; D009132:Muscles / Q000196:embryology* / Q000378:metabolism*; D018006:Myogenic Regulatory Factors; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D016335:Zinc Fingers / Q000235:genetics
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D064326:MEF2 Transcription Factors; C499409:Mef2 protein, Drosophila; D018006:Myogenic Regulatory Factors; D014157:Transcription Factors; C076904:Cf2 protein, Drosophila