[The advances in immunological research on xenotransplantation].
OBJECTIVE
To investigate the mechanism of xenotransplantation rejection and the interaction between the immunocytes.


METHODS
This review concluded the research achievements and new advances in xenotransplantation based on the relevant experimental data.


RESULTS
Transgenic pig technology and novel immunosuppressants were applied to suppress hyperacute rejection and acute vascular rejection respectively. Modulation of T cell and antigen presenting cells and induction of tolerance were taken for the prevention of acute cellular rejection.


CONCLUSIONS
In general, the technology of transgenic pig is relatively mature and effective. The mechanism and prevention of acute vascular rejection and acute cellular rejection should be further investigated.
Laboratory of Transplant Engineering & Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China 610041. feng31@sohu.com
Li
L
Feng
You-ping
YP
Li
D000818:Animals; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D013552:Swine; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous / Q000276:immunology*