Two new triterpenoids from Azadirachta indica and their insecticidal activity.
Two new triterpenoids, 22,23-dihydronimocinol (1) and desfurano-6alpha-hydroxyazadiradione (2), were isolated from a methanolic extract of the fresh leaves of Azadirachta indica (neem) along with a known meliacin, 7alpha-senecioyl-(7-deacetyl)-23-O-methylnimocinolide. The structures of 1 and 2 were elucidated through spectral and chemical studies. Compounds 1 and 2 showed mortality for fourth instar larvae of the mosquito (Anopheles stephensi), with LC(50) values of 60 and 43 ppm, respectively.
H.E.J. Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Pakistan. bina@khi.comsats.net.pk
Bina S
BS
Siddiqui
Farhana
F
Afshan
Shaheen
S
Faizi
Syed
S
Naeem-Ul-Hassan Naqvi
Rajput M
RM
Tariq
D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C466700:22,23-dihydronimocinol; D007306:Insecticides; D014315:Triterpenes; C466701:desfurano-6alpha-hydroxyazadiradione