Polyvinylalcohol substituted with triethyleneglycolmonoethylether as a new material for preparation of solid dispersions of hydrophobic drugs.
Among the different methods used to increase the aqueous drug solubility, the preparation of a solid dispersion with a soluble carrier represents an interesting formulative approach. We substituted polyvinylalcohol with triethyleneglycolmonoethylether and obtained a suitable material for the formulation of a solid dispersion of progesterone, by spray-drying. In particular, we evaluated the influence of the polyvinylalcohol substitution degree and the polymer-drug weight ratios in the preparative mixture on the progesterone dissolution rate in the aqueous environment.
Orienti
Isabella
I
Department of Pharmaceutical Sciences, Bologna University, Bologna, Italy. Orienti@biocfarm.unibo.it
Bigucci
Federica
F
Luppi
Barbara
B
Cerchiara
Teresa
T
Zuccari
Guendalina
G
Giunchedi
Paolo
P
Zecchi
Vittorio
V
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D004339:Drug Compounding; D004344:Drug Incompatibility; D012739:Gonadal Steroid Hormones / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D010592:Pharmaceutic Aids / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers; D011142:Polyvinyl Alcohol / Q000138:chemical synthesis / Q000737:chemistry*; D011374:Progesterone / Q000737:chemistry; D012995:Solubility; D013997:Time Factors
D004337:Drug Carriers; D012739:Gonadal Steroid Hormones; D010592:Pharmaceutic Aids; D011108:Polymers; D011092:Polyethylene Glycols; C035053:triethylene glycol monoethyl ether; D011374:Progesterone; D011142:Polyvinyl Alcohol