Uncommon vancomycin-induced side effects.
Vancomycin has been used with increased frequency during the past 15 years and the most common toxicity with this drug is the  red man syndrome . Other adverse effects include neutropenia, fever, phlebitis, nephrotoxicity, ototoxicity, thrombocytopenia, interstitial nephritis, lacrimation, linear IgA bullous dermatosis, necrotizing cutaneous vasculitis and toxic epidermal necrolysis. Only two cases of vancomycin-induced Stevens-Johnson syndrome and one case of pancytopenia have been reported in the medical literature. The treatment for both situations is based on cessation of the vancomycin therapy; in cases of Stevens-Johnson syndrome, antihistamine and/or steroid agents can be used. This article reports a case of pancytopenia and a case of erythema major associated with neutropenia.
Division of Infectious Disease, Nossa Senhora das Graças Hospital, Curitiba, Paraná, Brazil. jaimeluis@b.com.br
Jaime Luis Lopes
JL
Rocha
William
W
Kondo
Maria Inêz Domingues Kuchiki
MI
Baptista
Clovis Arns
CA
Da Cunha
Luzmila Terezinha Flenik
LT
Martins
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D004802:Eosinophilia / Q000139:chemically induced; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D005334:Fever / Q000139:chemically induced; D006622:Hip Prosthesis; D006801:Humans; D016106:Methicillin Resistance; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced*; D015242:Ofloxacin / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy; D011537:Pruritus / Q000139:chemically induced; D013210:Staphylococcus / Q000302:isolation & purification; D013577:Syndrome; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D014640:Vancomycin; D015242:Ofloxacin