The effects of benzodiazepines on event-related potential indices of automatic and controlled processing in schizophrenia: a preliminary report.
The effects of benzodiazepines on cognitive function in schizophrenic patients were investigated using event-related potential (ERP) measurement during an auditory selective attention task. In this study, the authors compared the mismatch negativity (MMN) and N2b components between two subgroups of schizophrenic patients: one is comprised of patients who received no benzodiazepines (NT group, n = 7) and the other is comprised of those administered benzodiazepines in the daytime (T group, n = 7). There were no significant differences in MMN and N2b amplitudes between the two subgroups, whereas the N2b latency was significantly prolonged in the T group relative to the NT group. This suggested that benzodiazepines induce delayed stimulus classification processing in schizophrenic patients.
Department of Neuropsychiatry, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Tadashi
T
Murakami
Kazuyuki
K
Nakagome
Satoru
S
Kamio
Kiyoto
K
Kasai
Akira
A
Iwanami
Ken-Ichi
K
Hiramatsu
Masato
M
Fukuda
Akinobu
A
Hata
Makoto
M
Honda
Akira
A
Watanabe
Nobumasa
N
Kato
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001569:Benzodiazepines / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D018709:Statistics, Nonparametric
D001569:Benzodiazepines