Mutation of NMDA receptor subunit epsilon 1: effects on audiogenic-like seizures induced by electrical stimulation of the inferior colliculus in mice.
It has been shown that the N-methyl-D-asparate (NMDA) receptor in the inferior colliculus is involved in the induction of audiogenic seizures (AGS). In the present study we examined audiogenic-like seizure susceptibility in GluR epsilon 1 null KO adult mice (n=32) and wild-type adult mice (n=28) by electrically stimulating the inferior colliculus (IC). Threshold current intensities of the GluR epsilon 1 KO mice for wild running, clonic and tonic seizures were higher than those of wild-type mice. In addition, the incidence rates of each seizure syndrome in GluR epsilon 1 KO mice were lower than in wild-type mice at each current intensity. These results show that GluR epsilon 1 KO mice were more resistant to audiogenic-like seizures induced by stimulating the IC. Thus, our findings suggest that the GluR epsilon 1 subunit plays an important role in regulating AGS.
Laboratory for Neurobiology of Emotion, Brain Science Institute (BSI), RIKEN, Wako-city, Saitama, Japan. tsakamoto@brain.riken.go.jp
Toshiro
T
Sakamoto
Masayoshi
M
Mishina
Hiroaki
H
Niki
D000818:Animals; D002478:Cells, Cultured; D004558:Electric Stimulation; D020195:Epilepsy, Reflex / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D007245:Inferior Colliculi / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000172:deficiency* / Q000235:genetics; D012640:Seizures / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000235:genetics
C120997:NR2A NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate