Calcium-D-glucarate.
Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables. Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers. Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent.
D000818:Animals; D016588:Anticarcinogenic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D004967:Estrogens / Q000378:metabolism; D005937:Glucaric Acid / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy / Q000517:prevention & control; D008113:Liver Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D008175:Lung Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D012878:Skin Neoplasms / Q000188:drug therapy / Q000517:prevention & control
D016588:Anticarcinogenic Agents; D000924:Anticholesteremic Agents; D004967:Estrogens; D005937:Glucaric Acid