The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?
Villin plays a key role in the maintenance of the brush border organization by bundling F-actin into a network of parallel filaments. Our previous in vivo data on villin knockout mice showed that, although this protein is not necessary for the bundling of F-actin, it is important for the reorganization of the actin cytoskeleton elicited by stress conditions. We further investigated villin property to initiate actin remodeling in cellular processes such as hepatocyte growth factor-induced motility, morphogenesis, and bacterial infection. Our data suggest that villin is involved in actin remodeling necessary for many cellular processes requiring the actin cytoskeleton plasticity.
Athman
Rafika
R
Laboratoire de morphogénèse et signalisation cellulaires, Institut Curie UMR 144, 75248 Paris cedex 05, France.
Louvard
Daniel
D
Robine
Sylvie
S
D000199:Actins / Q000502:physiology; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000502:physiology*; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology*; D013329:Structure-Activity Relationship
D000199:Actins; D002352:Carrier Proteins; D008840:Microfilament Proteins; C026615:villin