Effects of rinbacin extract on rat kidney.
The aqueous leaf extract of rinbacin was tested for toxic effects on prepubertal rat kidneys following chronic administration. Two doses of rinbacin extract (26.25 g/l and 52.50 g/l) were administered in the rats' drinking water for 13 weeks, and various toxicologic indices tested. Histological study of the kidneys was also carried out at the expiration of the test period. Rinbacin at both dose sizes significantly (p<0.05) increased the absolute and relative kidney weights. Also the serum HCO3- level was significantly (p<0.05) increased, while the serum K+ level was decreased significantly at both dose levels. Only the high dose significantly (p<0.05) increased the serum urea level of the rats. Histological study showed that rinbacin at both dose sizes caused renal pathologic changes, which included necrosis and cellular infiltration of glomeruli and epithelia of the tubules. The effects were less marked in the low dose than the high dose group. Chronic administration of rinbacin extract induces nephrotoxicity in young rats.
Afonne
Onyenmechi Johnson
OJ
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University Nnewi, Anambra State, Nigeria. connice@infoweb.abs.net
Orisakwe
Orish Ebere
OE
Dioka
Chudi Emma
CE
Obi
Ejeatuluchukwu
E
Ezejiofor
Tobias
T
Asomugha
Lasbery
L
Ukoha
Ukoha
U
D000818:Animals; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009549:Nigeria; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000633:toxicity*; D051381:Rats
D010936:Plant Extracts