Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature.
The aim of this study is to report on five cases of intraoral pleomorphic adenoma (PA) in patients under 18 years of age and to review the literature. Intraoral salivary gland tumours were reviewed in two Brazilian institutions and five cases of PA in patients under 18 years of age were found. Clinical data were obtained from the medical records and paraffin-embedded tissues were sectioned for proliferating cell nuclear antigen (PCNA) and p53 immunohistochemical analysis. Four patients were female and one was male; two cases affected the palate, two the upper lip and one the tongue. All five patients were treated surgically and after long follow-up periods no recurrences were observed. Tumour cells were weakly positive for PCNA and negative for p53. PA should be considered in the differential diagnosis of submucosal nodules in young patients. In youngsters, PA seems to have similar biological characteristics as in adults, with low recurrence rates after surgical resection.
Department of Oral Pathology and Semiology, School of Dentistry of Piracicaba, University of Campinas, SP, Brazil.
J
J
Jorge
F R
FR
Pires
F A
FA
Alves
D E C
DE
Perez
L P
LP
Kowalski
M A
MA
Lopes
O P
OP
Almeila
D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53