Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies.
A selective heteromeric supramolecular assembly process is devised to create functional single channels of altered ion conductance, charge selectivity, and rectification. The hollow transmembrane tubular structure produced spontaneously from the self-assembly of cyclic-d,l-alpha-peptides in lipid bilayers is modified by designer cyclic peptide "cap" subunits that bind site-selectively at the mouth of the channel assembly.
Sánchez-Quesada
Jorge
J
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
Isler
Markus P
MP
Ghadiri
M Reza
MR
D004553:Electric Conductivity; D004563:Electrochemistry; D007473:Ion Channels / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology; D008565:Membrane Proteins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D036103:Nanotechnology / Q000379:methods; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism
D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins; D010456:Peptides, Cyclic; D010713:Phosphatidylcholines