Unilateral generalized morphea in childhood.
We report a 6-year-old boy with unilateral generalized morphea distributing on the right side of his lower leg, trunk, and upper arm. A skin biopsy from the right thigh showed accumulation of thick collagen bundles extending from the middle dermis to the subcutaneous fat tissue. The levels of antinuclear antibodies, rheumatoid factor, and anti single-stranded DNA antibody were elevated. No severe deformity or functional disabilities were noted. With topical corticosteroid therapy, the sclerotic skin became gradually softer, and no progression of sclerosis has been noted for one year.
Nagai
Yayoi
Y
Division of Dermatology, Tone Central Hospital, Numata, Gunma, Japan.
Hattori
Tomoyasu
T
Ishikawa
Osamu
O
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000974:Antibodies, Antinuclear / Q000032:analysis; D001707:Biopsy, Needle; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D007866:Leg; D008297:Male; D012594:Scleroderma, Localized / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear