C-H activation and palladium migration within Biaryls under Heck reaction conditions.
[reaction: see text] Biaryl bromides such as 1 (R=NO(2), H, OMe) undergo the Heck reaction to give both the expected products 3 ("retention") as well as "crossover" products 4 derived from a migration of Pd and net transfer of reactivity from one aryl ring to the other. Under the conditions used, crossover is increasingly favored when electron-deficient arenes are involved. Crossover products derived from transfer onto the pyridine ring have also been observed.
School of Chemistry, University of Bristol, UK.
Gunter
G
Karig
Maria-Teresa
MT
Moon
Nopporn
N
Thasana
Timothy
T
Gallagher