Susceptibility of some clinical isolates of Staphylococcus aureus to bioactive column fractions from the lichen Ramalina farinacea (L.) Ach.
The antimicrobial activities of two bioactive column chromatographic fractions (RF1 and RF2) from the lichen Ramalina farinacea (L.) were evaluated against 15 clinical isolates of Staphylococcus aureus. The susceptibility pattern of the isolates towards tetracycline (TCN) and ampicillin (AMP) was similarly -evaluated for comparison purposes. The results show that RF1 and RF2 with an MIC(90) ( minimum -inhibitory concentration against 90% of the isolates) of 535.5 and 317 microg/mL respectively, performed generally better than TCN and AMP with an MIC(90) of 976.5 and 357 microg/mL respectively.
Division of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
C O
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Esimone
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Adikwu
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D018942:Macrolides; D010406:Penicillins; D010936:Plant Extracts; D000667:Ampicillin; D013752:Tetracycline