Diterpenoids from Cascarilla (Croton eluteria Bennet).
Cascarilla is a commercially available and cheap source of polyfunctionalized diterpenoids belonging to the clerodane structural type. In addition to the bitter triol cascarillin, 10 additional new diterpenoids (eluterins A-J) have been isolated and characterized by spectroscopic means. Structural diversity within cascarilla clerodanes involves mainly the linkage between the carbocyclic and the heterocyclic moieties and the functionalization of C-3, C-4, and C-6 of the decalin core. Cascarillin was shown to be a mixture of interconverting gamma-lactols and not a gamma-hydroxyaldehyde as previously reported.
Fattorusso
Ernesto
E
Dipartimento di Chimica delle Sostanze Naturali, Università Degli Studi di Napoli Federico II, Via Montesano 49, Italy. fattoru@unina.it
Taglialatela-Scafati
Orazio
O
Campagnuolo
Claudio
C
Santelia
Federico U
FU
Appendino
Giovanni
G
Spagliardi
Paola
P
D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D013057:Spectrum Analysis
D004224:Diterpenes; D010936:Plant Extracts