[Analytical choices for biological tests in thrombotic pathology].
The knowledge of genetic and occurred risk factors allows us to propose laboratory investigations in patients with thromboembolism (TE) to evaluate the risk for recurrence. Beside coagulation inhibitor deficiencies accounting for less than 10% of cases, factor V Leiden and prothrombin G20210A mutations are found in around 30% and 10% respectively. Increased factor VIII and hyperhomocysteinemia resulting from interaction of genetic factors and environmental factor are also risk factors for TE. Finally, antiphospholipid antibodies, a complex family of antibodies recognizing various phospholipid or phospholipid binding proteins, are also associated with TE.
Service d'hématologie biologique A, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris, France. martine.aiach@egp.ap-hop-paris.fr
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D019411:Clinical Laboratory Techniques; D005165:Factor V / Q000235:genetics; D005169:Factor VIII / Q000378:metabolism; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D009154:Mutation; D011516:Prothrombin / Q000235:genetics; D012008:Recurrence; D012307:Risk Factors; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D005169:Factor VIII