Solvent abuse in pregnancy: a perinatal perspective.
OBJECTIVE
To review the scope and sequelae of solvent abuse in women presenting to a Manitoba teaching hospital.


METHODS
Fifty-six patient charts with a diagnosis of solvent abuse in pregnancy were identified through computer search in the medical records of Winnipeg Health Sciences Centre, General Hospital. These charts were reviewed and data obtained from birthing records and associated pediatric charts.


RESULTS
Renal tubular acidosis was diagnosed in three patients (5.3%). Two patients (3.6%) had adverse neurological sequelae. One patient was diagnosed with brain damage, including expressive aphasia. Twelve patients (21.4%) delivered preterm infants. Nine infants (16.1%) had major anomalies. Seven infants (12.5%) had fetal alcohol syndrome (FAS)-like facial features. Six neonates (10.7%) had hearing loss.


CONCLUSIONS
Substance abuse in pregnancy is associated with severe maternal and neonatal sequelae. Physicians must be aware of this increasing problem in the obstetrical population and assistance should be offered to each woman, ideally before a woman becomes pregnant, but at least at the first contact a pregnant woman makes with the health care community.
Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB.
Jan J
JJ
Scheeres
Albert E
AE
Chudley
D000141:Acidosis, Renal Tubular / Q000139:chemically induced; D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000139:chemically induced; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology; D006769:Hospitals, General; D006801:Humans; D007223:Infant; D008350:Manitoba / Q000453:epidemiology; D009017:Morbidity; D007744:Obstetric Labor Complications / Q000139:chemically induced; D007752:Obstetric Labor, Premature / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000517:prevention & control; D011256:Pregnancy Outcome / Q000453:epidemiology; D011253:Pregnancy in Adolescence / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012997:Solvents / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control; D014050:Toluene / Q000009:adverse effects
D012997:Solvents; D014050:Toluene