HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor.
Human histocompatibility leukocyte antigen (HLA)-G is an MHC class Ib molecule that has been proposed to regulate immune responses during pregnancy. One of the possible mechanisms of that modulation is based on its interaction with immunoglobulin-like transcript (ILT) receptors. In this study, we show that HLA-G modifies the function of murine dendritic cells via interactions with the paired immunoglobulin-like inhibitory receptor, a homologue of the human inhibitory receptor ILT4. Triggering of the immune inhibitory receptors resulted in prolongation of allogeneic graft survival. This demonstration forms the basis for exploring and exploiting HLA-G molecules and immune inhibitory receptors in the development of a new therapeutic strategy to improve allogeneic graft survival.
Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta 30912, USA.
Siyuan
S
Liang
Boris
B
Baibakov
Anatolij
A
Horuzsko
D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007739:L Cells / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology*; D016038:Skin Transplantation / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D014162:Transfection; D014184:Transplantation, Homologous / Q000276:immunology*
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; C105949:Pirb protein, mouse; D011971:Receptors, Immunologic