Hole is a novel gene product expressed in the developing heart and brain.
Hole is a novel gene product isolated from a chick heart subtractive hybridization. Hole is a six-transmembrane protein (predicted size 311 and 317 amino acids in chick and mouse) expressed in the cardiac crescent and later in the myocardium of the developing chick heart, as well as in the fusing neural tube and ganglia. Mouse hole is not expressed in the developing heart, although it does share neural expression seen in the chick.
Stahlman Cardiovascular Laboratories, Program for Developmental Biology and The Division of Cardiovascular Medicine, Vanderbilt University, 2220 Pierce Avenue, MRBII 338, Nashville, TN 37232, USA. anna.nesset@mcmail.vanderbilt.edu
Anna L
AL
Nesset
David M
DM
Bader
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D002642:Chick Embryo; D018076:DNA, Complementary / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D011506:Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D011506:Proteins