Clopidogrel inhibits shear-induced platelet function.
We enrolled 17 healthy adult volunteers and measured platelet hemostasis time (PHT) and collagen-induced thrombus formation (CITF) before and after the oral administration of 300 mg of clopidogrel utilizing the Xylum Clot Signature Analyzer. We documented a statistically significant 30% prolongation of the PHT from 291+/-13 (SE) seconds to 376+/-31 (SE) s (P=0.037). There was a 7% prolongation of the CITF from 347+/-10 to 371+/-17 (SE) s (P=0.245). This study suggests that the Xylum Clot Signature Analyzer can measure changes in platelet function in response to a modest platelet inhibitor, and may be a useful clinical tool for the monitoring of antiplatelet therapies in patients.
Cardiac Catheterization Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA.
James L
JL
Orford
Scott
S
Kinlay
Mark R
MR
Adams
Daniel I
DI
Simon
Andrew P
AP
Selwyn
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects; D000077144:Clopidogrel; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D010477:Perfusion; D015539:Platelet Activation / Q000187:drug effects*; D010979:Platelet Function Tests; D013314:Stress, Mechanical; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*
D000077144:Clopidogrel; D013988:Ticlopidine