Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope.
GM(1)- and GD(1a)-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD(1a)-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD(1a)-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283, USA. nachamki@mail.med.upenn.edu
Irving
I
Nachamkin
Jirong
J
Liu
Ming
M
Li
Huong
H
Ung
Anthony P
AP
Moran
Martina M
MM
Prendergast
Kazim
K
Sheikh
D000942:Antigens, Bacterial / Q000235:genetics; D001483:Base Sequence; D016123:Campylobacter jejuni / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D004269:DNA, Bacterial / Q000235:genetics; D000939:Epitopes / Q000235:genetics; D005677:G(M1) Ganglioside / Q000235:genetics / Q000276:immunology; D005732:Gangliosides / Q000235:genetics / Q000276:immunology*; D015870:Gene Expression; D005798:Genes, Bacterial; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D018716:Molecular Mimicry; D012307:Risk Factors; D014774:Virulence / Q000235:genetics / Q000276:immunology
D000942:Antigens, Bacterial; D004269:DNA, Bacterial; D000939:Epitopes; D005732:Gangliosides; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides; C021298:ganglioside, GD1a; D005677:G(M1) Ganglioside