Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports.
The differential diagnosis between brain abscesses and necrotic tumors such as glioblastomas is sometimes difficult to establish by conventional computed tomography and magnetic resonance imaging. Combined proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted magnetic resonance imaging (DWI) were used to establish the preoperative diagnosis of brain abscess and glioblastoma. DWI visualized the brain abscess as a homogeneous hyperintense lesion and 1H-MRS revealed the presence of acetate, lactate, and amino acids and the absence of the normal brain components. DWI sometimes shows glioblastoma as a hyperintense lesion, but 1H-MRS reveals markedly increased lactate and decreased N-acetyl-aspartate. Combined DWI and 1H-MRS findings can distinguish brain abscess and glioblastoma.
Department of Neurosurgery, School of Medicine, The University of Tokushima, Japan.
Mami
M
Nakaiso
Masaaki
M
Uno
Masafumi
M
Harada
Teruyoshi
T
Kageji
Osamu
O
Takimoto
Shinji
S
Nagahiro
D000085:Acetates / Q000378:metabolism; D000328:Adult; D000596:Amino Acids / Q000378:metabolism; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001922:Brain Abscess / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004058:Diffusion; D005625:Frontal Lobe / Q000473:pathology; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement; D019344:Lactic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009778:Occipital Lobe / Q000473:pathology; D012016:Reference Values
D000085:Acetates; D000596:Amino Acids; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate