Olfactory axon pathfinding: who is the pied piper?
Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate the stereotyped olfactory bulb map are the same as those needed for appropriate expression of the OR.
Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
Rajesh
R
Ranganathan
Linda B
LB
Buck
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005818:Genetic Engineering / Q000379:methods; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009830:Olfactory Bulb / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D009833:Olfactory Pathways / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D018035:Receptors, Odorant / Q000235:genetics*; D019076:Transgenes / Q000235:genetics*
D018035:Receptors, Odorant