Oestrogen-induced bone marrow aplasia in a dog with a Sertoli cell tumour.
A 10-year-old male Drahthaar dog with unilateral cryptorchidism was examined because of feminisation and myelotoxicity. Radiography and ultrasonography revealed an abdominal mass which was surgically removed. The mass was identified as a Sertoli cell tumour on histological examination. Findings on bone marrow examination were compatible with aplasia due to the oestrogens secreted by the tumoral cells. Treatment with fluids, antibiotics, whole blood transfusions, corticosteroids and lithium carbonate was unsuccessful. Survival time was 22 days after surgery.
Hospital Veterinari Via Aurèlia, Barcelona, Spain.
N
N
Sanpera
N
N
Masot
M
M
Janer
C
C
Romeo
R
R
de Pedro
D000818:Animals; D001855:Bone Marrow Diseases / Q000662:veterinary*; D004283:Dog Diseases / Q000503:physiopathology* / Q000601:surgery; D004285:Dogs; D004967:Estrogens / Q000009:adverse effects / Q000096:biosynthesis*; D008297:Male; D012707:Sertoli Cell Tumor / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*
D004967:Estrogens