Cytomegalovirus-induced glomerular vasculopathy in renal allografts: a report of two cases.
Cytomegalovirus (CMV) remains a major viral pathogen complicating renal transplantation. Tubulointerstitial nephritis is the commonly acknowledged and well-characterized pathologic feature of renal allograft CMV disease. There is controversy about whether there is a distinct entity as a CMV glomerulopathy in the absence of tubulointerstitial disease. We describe two patients with renal allograft dysfunction who displayed distinct features of CMV glomerular vasculopathy, in the absence of overt viral cytopathic changes involving the tubules.
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA. monuigbo27@hotmail.com
Macaulay
M
Onuigbo
Abdolreza
A
Haririan
Emilio
E
Ramos
David
D
Klassen
Ravinder
R
Wali
Cynthia
C
Drachenberg
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology* / Q000821:virology; D016030:Kidney Transplantation / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology* / Q000821:virology
D000914:Antibodies, Viral