In vitro glucocorticoid resistance in childhood leukemia correlates with receptor affinity determined at 37 degrees C, but not with affinity determined at room temperature.
Haarman
E G
EG
Kaspers
G J L
GJ
Pieters
R
R
Rottier
M M A
MM
Den Boer
M L
ML
Janka-Schaub
G E
GE
Veerman
A J P
AJ
D000208:Acute Disease; D018931:Antineoplastic Agents, Hormonal / Q000378:metabolism*; D001853:Bone Marrow / Q000737:chemistry; D002648:Child; D003907:Dexamethasone / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D066298:In Vitro Techniques; D007951:Leukemia, Myeloid / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013696:Temperature
D018931:Antineoplastic Agents, Hormonal; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone