Synthesis and antiaggregant properties of Stabilized analogues of polyunsaturated fatty acid metabolites.
New aromatic and heteroaromatic analogues of polyunsaturated fatty acid metabolites have been prepared using short and versatile strategies. Preliminary studies of their activity as inhibitors of platelet aggregation are reported.
ENSCR, Synthèses et Activations de Biomolécules, CNRS UMR 6052, Avenue du Gal Leclerc, 35700, Rennes, France.
Ali
A
Hachem
Patrick
P
Roussel
Eric
E
Ménager
Danielle
D
Grée
Yves
Y
Le Floc'h
René
R
Grée
Chiara
C
Cerletti
Yves
Y
Rolland
Serge
S
Simonet
Tony
T
Verbeuren
D000818:Animals; D002478:Cells, Cultured; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits
D005231:Fatty Acids, Unsaturated; D010975:Platelet Aggregation Inhibitors