Bioavailability studies on fast release formulations of indomethacin.
Indomethacin-nicotinamide solid dispersions were prepared by fusion method. Drug-carrier interaction in the liquid and solid states were studied using phase solubility data and differential scanning colorimetry (DSC). DSC revealed the formation of an eutectic mixture of indomethacin and nicotinamide. Tablets and capsules, formulated from the solid dispersions showed significantly better dissolution and enhanced absorption rate in human volunteers, compared to commercial capsule of indomethacin.
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.
M M
MM
Verma
M T
MT
Kumar
J
J
Balasubramaniam
J K
JK
Pandit
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000032:analysis / Q000493:pharmacokinetics*; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D002214:Capsules; D006207:Half-Life; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics*; D008297:Male; D012995:Solubility; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D013607:Tablets; D007213:Indomethacin