Severe Coxsackie virus B infection in preterm newborns treated with pleconaril.
Four preterm newborn infants with severe multisystem Coxsackie virus B infection were treated with an oral suspension of pleconaril (5 mg/kg per day). The patients had myocarditis, fulminant hepatitis, meningoencephalitis and disseminated intravascular coagulopathy. All four infants recovered, and no adverse effects of the treatment were noted.


CONCLUSIONS
pleconaril needs to be comprehensively evaluated in this population.
Bauer
Sofia
S
Neonatal Intensive Care Unit, Meir General Hospital, Kfar-Saba, The Sackler School of Medicine, Tel Aviv University, Israel.
Gottesman
Giora
G
Sirota
Lea
L
Litmanovitz
Ita
I
Ashkenazi
Shay
S
Levi
Itzhak
I
D000998:Antiviral Agents / Q000627:therapeutic use*; D003384:Coxsackievirus Infections / Q000188:drug therapy*; D004200:Diseases in Twins; D029822:Enterovirus B, Human / Q000187:drug effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010069:Oxadiazoles / Q000627:therapeutic use*; D010080:Oxazoles
D000998:Antiviral Agents; D010069:Oxadiazoles; D010080:Oxazoles; C115201:pleconaril