Ageing: repair and transcription keep us from premature ageing.
Trichothiodystrophy (TTD) is a complex disorder caused by mutations in the XPD gene which affect both DNA repair and transcription. A mouse with a TTD mutation has now been found to display remarkable signs of premature ageing.
Genome Damage and Stability Centre, University of Sussex, Falmer, BN1 9RQ, Brighton, UK. arlehmann@sussex.ac.uk
Alan
A
Lehmann
D000015:Abnormalities, Multiple; D000375:Aging / Q000502:physiology*; D019588:Aging, Premature / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D003057:Cockayne Syndrome / Q000235:genetics; D004249:DNA Damage; D004265:DNA Helicases; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D006197:Hair / Q000002:abnormalities; D006801:Humans; D051379:Mice; D009154:Mutation; D010641:Phenotype; D011506:Proteins / Q000235:genetics; D014157:Transcription Factors; D014158:Transcription, Genetic; D051760:Xeroderma Pigmentosum Group A Protein; D051759:Xeroderma Pigmentosum Group D Protein
D004268:DNA-Binding Proteins; D011506:Proteins; D014157:Transcription Factors; C497314:XPA protein, human; D051760:Xeroderma Pigmentosum Group A Protein; C497315:Xpa protein, mouse; D004265:DNA Helicases; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human; C497293:Ercc2 protein, mouse