Study of interaction of gastrointestinal agents in the presence of cytoprotective drugs. Part II. In vitro study on the adsorption of selected spasmolytic drugs on sucralfate.
The subject of the research was the adsorption of selected musculotropic and cholinolytic spasmolytics on a cytoprotective drug--sucralfate. Adsorption evaluation was made by a static method, in vitro, the environment reaction, the concentrations of the tested drugs and the sucralfate form being taken into account. The obtained results prove that the analysed therapeutic substances are adsorbed on the sucralfate in all pH. The highest bonding capacity was observed in tests at pH=3.6, in the presence of sucralfate, which at this pH occurs in the form of suspension. The lowest capacity was at pH=1.5 in the presence of sucralfate in the paste form. In the group of the tested drugs, scopolamine butylbromide is adsorbed best, drotaverine hydrochloride little less and papaverine hydrochloride least of all.
Pluta
J
J
Department of Applied Pharmacy, Medical University of Wrocław, Poland.
Grimling
B
B
D000327:Adsorption / Q000187:drug effects; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D019610:Cytoprotection; D004347:Drug Interactions; D005765:Gastrointestinal Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D010276:Parasympatholytics / Q000737:chemistry / Q000493:pharmacokinetics*; D013392:Sucralfate / Q000737:chemistry / Q000493:pharmacokinetics*
D000897:Anti-Ulcer Agents; D005765:Gastrointestinal Agents; D010276:Parasympatholytics; D013392:Sucralfate