Empirical model for the molar rotations of syn-2,2-dimethyl-1,3-dioxanes.
[structure: see text] A useful method for the prediction of molar rotation ([Phi]) of syn-2,2-dimethyl-1,3-dioxanes (acetonides) is described. A series of acetonides were prepared by standard methods. A simple additive relationship between the substituents (R, R') and molar rotation was realized.
Department of Chemistry, 516 Rowland Hall, University of California-Irvine, 92697-2025, USA.
Christopher D
CD
Anderson
Scott D
SD
Rychnovsky
D001685:Biological Factors / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry*; D008722:Methods; D008958:Models, Molecular; D009904:Optical Rotation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001685:Biological Factors; D004146:Dioxanes; C002483:dimethyldioxane