Absence of canine oral papillomavirus DNA following prophylactic L1 particle-mediated immunotherapeutic delivery vaccination.
In the canine oral papillomavirus (COPV) model, following wart regression, COPV DNA was detected by PCR at the challenge site. However, following particle-mediated immunotherapeutic delivery (PMID) of COPV L1 and subsequent challenge, no COPV DNA could be detected. These data support PMID of COPV L1 as a protective vaccine and suggest that PMID of L1 may induce virus clearance.
Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK1.
R A
RA
Moore
Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK1.
P K
PK
Nicholls
Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK1.
E B
EB
Santos
Glaxo Smithkline Research and Development, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, UK2.
G W
GW
Gough
Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK1.
M A
MA
Stanley
D000278:Administration, Buccal; D000818:Animals; D004279:DNA, Viral / Q000032:analysis*; D004195:Disease Models, Animal; D004285:Dogs; D009061:Mouth Mucosa / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000627:therapeutic use; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D014860:Warts / Q000188:drug therapy / Q000517:prevention & control* / Q000821:virology
D004279:DNA, Viral; D019444:Vaccines, DNA; D014765:Viral Vaccines