Characterisation of new oligoglycosidic compounds in two Chinese medicinal herbs.
A series of caffeic acid derivatives (3,5-dicaffeoyl-quinic acid, 3,4-dicaffeoyl-quinic acid, and 4,5-dicaffeoyl-quinic acid), and the new compound beta,3,4-trihydroxyphenethyl-O-[beta-apiofuranosyl-(1-->4)-alpha- rhamnopyranosyl-(1-->3)]-(4-O-caffeoyl)-beta-glucopyranoside (wedelosin), as well as three known flavonoid glycosides (quercetin 3-O-beta-glucoside, kaempferol 3-O-beta-apiosyl-(1-2)-beta-glucoside, and astragalin or kaempferol 3-O-beta-glucoside) were isolated from the Chinese medicinal herb Wedelia chinensis. Wedelosin showed an inhibitory activity on both the classical and the alternative activation pathway of the complement system. Another Chinese medicinal herb, Kyllinga brevifolia, yielded two known flavonoid glycosides [kaempferol 3-O-beta-apiosyl-(1-2)-beta-glucoside and isorhamnetin 3-O-beta-apiosyl-(1-2)-beta-glucoside], and a new quercetin triglycoside [quercetin 3-O-beta-apiofuranosyl-(1-->2)-beta-glucopyranoside 7-O-alpha-rhamnopyranoside]. The latter compound showed a moderate anti-viral activity.
Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
Sandra
S
Apers
Ying
Y
Huang
Sabine
S
Van Miert
Roger
R
Dommisse
Dirk Vanden
DV
Berghe
Luc
L
Pieters
Arnold
A
Vlietinck
D000998:Antiviral Agents / Q000032:analysis / Q000494:pharmacology; D003169:Complement Inactivator Proteins / Q000032:analysis / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006027:Glycosides / Q000032:analysis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet
D000998:Antiviral Agents; D003169:Complement Inactivator Proteins; D004365:Drugs, Chinese Herbal; D006027:Glycosides