A liquid-phase peptide synthesis in cyclohexane-based biphasic thermomorphic systems.
Combinations of typical organic solvents composed of cyclohexane and qualified aprotic polar organic solvents were found to realize an effective, biphasic thermomorphic system in arbitrary ratios of upper and lower phases that enable a practical application of a liquid-phase peptide synthesis.
Laboratory of Bio-Organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan. chiba@cc.tuat.ac.jp
Kazuhiro
K
Chiba
Yusuke
Y
Kono
Shokaku
S
Kim
Kohsuke
K
Nishimoto
Yoshikazu
Y
Kitano
Masahiro
M
Tada
D000596:Amino Acids; D003510:Cyclohexanes / Q000737:chemistry; D005449:Fluorenes; D008722:Methods; D010455:Peptides / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry
D000596:Amino Acids; D003510:Cyclohexanes; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides; D012997:Solvents