Evaluation of the role of contact sensitization and photosensitivity in the pathogenesis of poikiloderma of Civatte.
BACKGROUND
Poikiloderma of the face and neck (Civatte) is a rather common, indolent, chronic dermatosis, most often affecting menopausal females. Cumulative excessive sun exposure, a phototoxic or a photoallergic reaction, hormonal changes of menopause and genetic factors have all been incriminated in its obscure aetiopathogenesis.


OBJECTIVE
To evaluate the role of contact sensitization and photosensitivity in the pathogenesis of poikiloderma of Civatte (PC).


METHODS
Thirty-two patients (24 females and eight males, age range 38-74 years) with PC were patch tested with the European standard series and the fragrance series, and were photopatch tested with the photoallergens series. Additionally, photo-testing with a monochromator was performed.


RESULTS
Thirteen of 32 patients (40.62%) had one or more positive reactions to allergens of the standard series. Eight patients (25%) had positive reactions to fragrance mix and/or Balsam of Peru, which are included in the standard series, or to allergens of the fragrance series. Nickel sulphate was the single most common cause of contact sensitization (18.75%) among our patients. Ninety-seven subjects, who were patch tested with the standard series for suspected allergic contact dermatitis of the face and/or neck, served as age, sex and site controls. Of these, nine (9.27%) had one or more positive reactions to fragrance compounds. Statistical analysis showed a statistically significant difference in the frequency of positive reactions to fragrances between the PC group and the control group (chi2 value = 3.91, P < 0.05). In contrast, none of the PC patients had a positive photopatch test for the allergens included in the photoallergens series. The estimated minimal erythemal dose for the PC group was in all cases within normal limits for all wavelengths of ultraviolet (UV) radiation examined.


CONCLUSIONS
Contact sensitization, mostly to perfume ingredients, may develop in PC, possibly playing a pathogenetic part, at least in a subset of patients. Despite negative results of photopatch testing, an allergic photo-contact reaction cannot be definitely excluded. PC seems not to be a photosensitivity disorder of the type of chronic actinic dermatitis. UV radiation-induced dermal connective tissue changes are the predominant histological feature of PC, leading to telangiectasia due to loss of vascular support. Reticular pigmentation may result from a delayed hypersensitivity reaction to perfume and/or cosmetic ingredients. Patch testing with the standard series and avoidance of documented allergens may be of value in patients with PC.
Katoulis
A C
AC
National and Kapodistrian University of Athens, Department of Dermatology and Venereology, 'A. Sygros' Hospital, Athens, Greece.
Stavrianeas
N G
NG
Katsarou
A
A
Antoniou
C
C
Georgala
S
S
Rigopoulos
D
D
Koumantaki
E
E
Avgerinou
G
G
Katsambas
A D
AD
D000328:Adult; D000368:Aged; D000485:Allergens / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000150:complications*; D005148:Facial Dermatoses / Q000209:etiology; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D010787:Photosensitivity Disorders / Q000150:complications*; D013684:Telangiectasis / Q000209:etiology*
D000485:Allergens; D010476:Perfume