[Use of recombinant human TSH for stimulation of iodine radioisotope uptake in metastases of thyroid cancer during therapy with 131I].
The diagnostics with the use of recombinant human TSH for the follow-up of differentiated thyroid carcinoma (DTC) has been already approved. In more than 400 diagnostic scans, rhTSH proved to be effective in promoting 131I uptake in thyroid remnants and DTC metastases in patients receiving suppressive doses of thyroxine. However, information about its application in radioiodine treatment of DTC are scarce, especially with respect to patients with metastatic disease. In this review we have described our own results obtained during rhTSH aided radioiodine treatment of 42 patients with advanced DTC with reference to current literature data about diagnostic and therapeutic application of rhTSH.
Roskosz
J
J
Zakładu Medycyny Nuklearnej i Endokrynologii Onkologicznej, Centrum Onkologii-Instytut im. M. Skłodowskiej-Curie, Oddział w Gliwicach.
Handkiewicz-Junak
D
D
Turska
M
M
Wygoda
Z
Z
Jurecka-Tuleja
B
B
Jarzab
B
B
D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D009362:Neoplasm Metastasis; D011878:Radiotherapy / Q000379:methods*; D011994:Recombinant Proteins; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D013972:Thyrotropin / Q000008:administration & dosage*
D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin