[Effect of oxidized indoles on monoamine oxidase activity in the rat brain mitochondria].
There is increasing evidence, that oxidized indoles, isatin, 5-hydroxyoxindole, 2-oxindole, play important regulatory functions in the brain. Isatin and 5-hydroxyoxindole share some common regulatory properties in cell cultures (Cane et al., 2000, BBRC, 276, 379), however, their effects on brain mitochondrial monoamine oxidases, a potential target for their action, have not been compared yet. Isatin acted as a rather selective monoamine oxidase B inhibitor, whereas 5-hydroxyoxindole was more selective monoamine oxidase A inhibitor, but it was less potent than that of 5-hydroxyisatin, a synthetic analogue of isatin.
Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow. crumeyrolle@univ-paris12.fr
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Crumeyrolle
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Tournaire
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Cane
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Medvedev
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D006801:Humans; D007211:Indoles / Q000378:metabolism* / Q000494:pharmacology; D007510:Isatin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D000078183:Oxindoles; D051381:Rats
C464900:5-hydroxy-2-oxindole; C464901:5-hydroxyisatin; D007211:Indoles; D000078183:Oxindoles; D007510:Isatin; D008995:Monoamine Oxidase