[The treatment of peptic ulcer in elderly CRF patients].
It is well known that CRF patients may suffer from various types of upper GI tract lesions such as esophagitis, erosive or atrophic gastritis, gastro-duodenal ulcers and polyps. Above all, acute gastric mucosal lesion with atrophic changes has been complicated with elderly CRF patients in relatively high frequency in recent years. A number of causes for upper GI tract lesions in CRF patients have been raised, which include mental and physical stresses, hypergastrinemia associated with lower renal metabolic clearance rate, secondary hyperparathyroidism, hypoperfusion in gastric mucosal blood flow, malnutrition, and also H. pylori recently. The treatments for these upper GI tract lesions are directed toward both suppression of offensive factors and strengthening of defensive factors in gastro-duodenal mucosae. It is needless to say that special attentions should be always paid for doses, intervals or durations in any drugs prescribed for elderly CRF patients because of lower renal metabolic clearance rates for drugs.
Department of Internal Medicine, Tsurumi Westside Hospital.
Hitoshi
H
Iwabuchi
Kenzo
K
Matsuzaki
D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000863:Antacids / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy; D006635:Histamine H2 Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008657:Metabolic Clearance Rate; D010437:Peptic Ulcer / Q000209:etiology / Q000628:therapy*; D054328:Proton Pump Inhibitors
D000863:Antacids; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D000658:Amoxicillin; D017291:Clarithromycin