LAG1 puts the focus on ceramide signaling.
Longevity-assurance gene 1 (LAG 1) is a yeast longevity gene. Homologues of the Lag 1 protein can be found throughout phylogeny, although sequence similarity is very limited. The Lag 1 protein is located in the endoplasmic reticulum (ER), where it helps to accelerate the transport of glycosylphosphatidylinositol (GPI)-anchored proteins to the Golgi. This function of Lag 1 p results from its participation in ceramide synthesis. Thus, Lag 1 p and its homologues are likely to play a role in ceramide signaling, which affects growth, proliferation, stress resistance, and apoptosis. This provides a wide range of physiologic processes through which Lag 1 p may impinge upon life span.
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, PO Box P7-2, New Orleans, LA 70112, USA. sjazwi@1suhsc.edu
S Michal
SM
Jazwinski
Andreas
A
Conzelmann
D000595:Amino Acid Sequence; D000818:Animals; D002518:Ceramides / Q000378:metabolism*; D005800:Genes, Fungal; D008017:Life Expectancy; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D002518:Ceramides; C087436:LAG1 protein, S cerevisiae; D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins