Spectrophotometric determination of phenylephrine hydrochloride in pharmaceuticals by flow injection analysis exploiting the reaction with potassium ferricyanide and 4-aminoantipyrine.
This paper presents a method for the determination of phenylephrine hydrochloride in pharmaceuticals by spectrophotometric flow injection analysis exploiting the reaction with potassium ferricyanide and 4-aminoantipyrine, which leads to the formation of a condensation product with strong absorptivity at 500 nm. The linear dynamic range was between 0.95 and 9 mg/L, with a limit of detection of 0.2 mg/L and a sampling throughput of 120 samples per hour. The method was applied to eyewashes and nasal decongestant liquid medicines.
Rocha
José R C
JR
Universidade de São Paulo, Instituto de Química, SP, Brazil.
Galhardo
Cristiane X
CX
Natividade
Maria Auxiliadora E
MA
Masini
Jorge C
JC
D000675:Ampyrone; D003124:Colorimetry; D005292:Ferricyanides; D017022:Flow Injection Analysis / Q000379:methods*; D014663:Nasal Decongestants / Q000032:analysis; D009883:Ophthalmic Solutions / Q000032:analysis; D019999:Pharmaceutical Solutions / Q000032:analysis; D010656:Phenylephrine / Q000031:analogs & derivatives* / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods*
D005292:Ferricyanides; D014663:Nasal Decongestants; D009883:Ophthalmic Solutions; D019999:Pharmaceutical Solutions; D000675:Ampyrone; D010656:Phenylephrine; C028033:potassium ferricyanide; C426872:phenylephrone