Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption.
Hepcidin is an anti-microbial peptide predicted to be involved in the regulation of intestinal iron absorption. We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response. In each case, elevated hepcidin expression correlated with reduced iron absorption and depressed levels of iron-transport molecules. These data are consistent with hepcidin playing a role as a negative regulator of intestinal iron absorption.
Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Queensland 4029, Australia. gregA@qimr.edu.au
G J
GJ
Anderson
D M
DM
Frazer
S J
SJ
Wilkins
E M
EM
Becker
K N
KN
Millard
T L
TL
Murphy
A T
AT
McKie
C D
CD
Vulpe
D000209:Acute-Phase Proteins / Q000235:genetics; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics*; D064451:Hepcidins; D007408:Intestinal Absorption / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007501:Iron / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000209:Acute-Phase Proteins; D023181:Antimicrobial Cationic Peptides; D002352:Carrier Proteins; C578703:Hamp protein, rat; D064451:Hepcidins; D007501:Iron