Aqueous One-Pot Synthesis of Derivatized Cyclopentadienyl-Tricarbonyl Complexes of (99m) Tc with an In Situ CO Source: Application to a Serotonergic Receptor Ligand.
Instant radiopharmaceuticals-just add [(99m) TcO4 ](-) in water! Half-sandwich complexes of the type [(RCOCp)(99m) Tc(CO)3 ] (e.g. 1) were synthesized in a single step in water from [(99m) TcO4 ](-) . The acidification of the Cp ring by a carbonyl substituent and the use of K2 [H3 BCO2 ] as a reducing agent and in situ source of CO are instrumental in the synthesis.
Wald
J
J
Institute of Inorganic Chemistry, University of Zürich Winterthurerstrasse 190, 8057 Zürich, Switzerland, Fax: (+41) 1-635-68-03.
Alberto
R
R
Ortner
K
K
Candreia
L
L
carbonylation; cyclopentadienyl ligands; radiopharmaceuticals; rhenium; technetium