Identification of genes affecting Salmonella enterica serovar enteritidis infection of chicken macrophages.
Screening of 7,680 Salmonella enterica serovar Enteritidis mutants for attenuation in a chicken macrophage infection model yielded a series of mutants including several with defects in previously unrecognized Salmonella virulence genes. One of the newly identified genes was the pbpA2 gene, belonging to the penicillin binding protein gene family.
Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands.
Yixian
Y
Zhao
Ruud
R
Jansen
Wim
W
Gaastra
Ger
G
Arkesteijn
Bernard A M
BA
van der Zeijst
Jos P M
JP
van Putten
D000818:Animals; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000235:genetics; D002645:Chickens; D005798:Genes, Bacterial; D006602:Hexosyltransferases; D066298:In Vitro Techniques; D008264:Macrophages / Q000382:microbiology*; D005810:Multigene Family; D002267:Muramoylpentapeptide Carboxypeptidase / Q000235:genetics; D009154:Mutation; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D019779:Salmonella enterica / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase