Spatial memory dissociations in mice lacking GluR1.
Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, both on the hidden platform watermaze task and on an appetitively motivated Y-maze task. In contrast, they showed a specific spatial working memory impairment during tests of non-matching to place on both the Y-maze and an elevated T-maze. In addition, successful watermaze and Y-maze reference memory performance depended on hippocampal function in both wild-type and mutant mice; bilateral hippocampal lesions profoundly impaired performance on both tasks, to a similar extent in both groups. These results suggest that different forms of hippocampus-dependent spatial memory involve different aspects of neural processing within the hippocampus.
Reisel
D
D
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK.
Bannerman
D M
DM
Schmitt
W B
WB
Deacon
R M J
RM
Flint
J
J
Borchardt
T
T
Seeburg
P H
PH
Rawlins
J N P
JN
D000818:Animals; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D017774:Long-Term Potentiation / Q000235:genetics*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009154:Mutation / Q000235:genetics; D009434:Neural Pathways / Q000503:physiopathology*; D009474:Neurons / Q000378:metabolism; D018091:Receptors, AMPA / Q000172:deficiency* / Q000235:genetics; D013028:Space Perception / Q000502:physiology*; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D018091:Receptors, AMPA