Helicobacter pylori-specific immune responses of children: implications for future vaccination strategy.
We analyzed the specific anti-Helicobacter pylori immunoglobulin G (IgG) antibody profile for a sample of 824 asymptomatic schoolchildren in southern Germany (mean age, 10.7 +/- 0.65 years) with an H. pylori-specific IgG enzyme-linked immunosorbent assay and Western blot analysis. The prevalence of infection was 19.8% (95% confidence interval, 17.1 to 22.7%). The immunoresponses were characterized predominantly by antibodies against low-molecular-mass antigens of 14 and 29 kDa, with a significant difference between children of German and Turkish nationalities (P = 0.0012 and P < 0.0001, respectively).
Bode
Günter
G
Department of Epidemiology, University of Ulm, Germany.
Piechotowski
Isolde
I
Rothenbacher
Dietrich
D
Brenner
Hermann
H
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines; D002648:Child; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G