Ontogenetic study of the effects of energetic nutrients on amino acid metabolism of rat cerebral cortex.
We studied the effect of various energetic nutrients on metabolism of L-[U-14C]leucine and [1-14C]glycine in cerebral cortex of rats at different ages. At gestational age, glucose and lactate stimulated protein synthesis from L-[U-14C]leucine and [1-14C]glycine and from L-[U-14C]leucine, respectively; glucose, beta-OH-butyrate and lactate stimulated lipid synthesis from L-[U-14C]leucine. At 10 days of age, glucose, mannose, and fructose stimulated protein synthesis, and glucose and mannose stimulated oxidation to CO2 as well as lipid synthesis from L-[U-14C]leucine. In adult rats, glucose, mannose, and fructose stimulated protein synthesis from L-[U-14C]leucine and [1-14C]glycine; glutamine also markedly decreased the oxidation of L-[U-14C]leucine and [1-14C]glycine in 10-day-old and adult rats.
Departamento de Ciências da Saúde, UNIJUI/IJUI, RS, Brazil.
Karla R
KR
de Oliveira
Liane N
LN
Rotta
Sandra C
SC
Valle
Diogo A
DA
Pilger
Cristina W
CW
Nogueira
Ana M
AM
Feoli
Elena A
EA
Bernard
Diogo O
DO
Souza
Marcos L S
ML
Perry
D000375:Aging / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004734:Energy Metabolism; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids