Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation.
This brief review presents the basic premises suggesting that insulin-like growth factor I (IGF-I), functioning in an autocrine/paracrine mode, is an important mediator of skeletal muscle adaptation. Key intracellular signaling mechanisms associated with ligation of the primary IGF-I receptor are highlighted to illustrate the mechanisms by which IGF-I may promote muscle hypertrophy. In addition, a number of recent findings are presented that highlight the potential for interactions between IGF-I-related signaling pathways and intracellular signaling mechanisms activated by cytokines or hormonal systems.
Adams
Gregory R
GR
Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA. gradams@uci.edu
D000222:Adaptation, Physiological; D000818:Animals; D019898:Autocrine Communication / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D009043:Motor Activity / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D019899:Paracrine Communication / Q000502:physiology*; D015398:Signal Transduction
D007328:Insulin; D007334:Insulin-Like Growth Factor I