Intrathecal IgM synthesis predicts the onset of new relapses and a worse disease course in MS.
BACKGROUND
The authors have recently described that intrathecal IgM synthesis (ITMS) correlates with a higher disability in patients with clinically definite MS (CDMS).


OBJECTIVE
To follow-up a group of patients with MS in the initial stages of the disease to evaluate if the presence of ITMS correlates with a worse evolution.


METHODS
Oligoclonal IgM bands were performed in 22 patients with MS with a mean of 1.14 months of evolution. Patients were followed for a period ranging from 6 to 36 months (mean, 21.4 months). During follow-up, time to conversion to CDMS, number of relapses, and changes in Expanded Disability Status Scale (EDSS) score were evaluated.


RESULTS
Patients were divided into two groups according to the presence (Group 1, 10 patients) or absence (Group 2, 12 patients) of ITMS. No clinical differences were observed between the groups at inclusion in the study. During the follow-up, the probability of conversion to CDMS was greater in Group 1 (90% of the patients had converted to CDMS after 8 months of follow-up) than in Group 2 (51% of patients had converted to CDMS after 36 months of follow-up) (p = 0.0001). Patients from Group 1 had more relapses (mean, 2.0) than those from Group 2 (mean, 0.58) (p = 0.02). At the end of the study, patients from Group 1 had higher EDSS scores (mean, 1.70) than those from Group 2 (mean, 0.79) (p = 0.02).


CONCLUSIONS
The presence of oligoclonal IgM bands in CSF can be a prognostic marker in the early phases of MS.
Department of Immunology Hospital Ramón y Cajal, Madrid, Spain. lvillar@hrc.insalud.es
L M
LM
Villar
J
J
Masjuan
P
P
González-Porqué
J
J
Plaza
M C
MC
Sádaba
E
E
Roldán
A
A
Bootello
J C
JC
Alvarez-Cermeño
D000293:Adolescent; D000328:Adult; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid*; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000276:immunology*; D011237:Predictive Value of Tests; D055502:Secondary Prevention; D012720:Severity of Illness Index
D007075:Immunoglobulin M; D016899:Interferon-beta