An amphiphilic resin-supported palladium catalyst for high-throughput cross-coupling in water.
[reaction: see text] The Suzuki-Miyaura coupling of aryl halides (8 varieties) and aryl- or vinylboronic acids (12 varieties) took place in water in the presence of a palladium complex of an amphiphilic polystyrene-poly(ethylene glycol) copolymer resin-supported N-anchored 2-aza-1,3-bis(diphenylphosphino)propane ligand and potassium carbonate to give uniform and quantitative yields of the corresponding biaryls (96 varieties).
Uozumi
Yasuhiro
Y
Institute for Molecular Science and The Graduate University for Advanced Studies, Nishi-Gonaka 38, Myodaiji, Okazaki 444-8585, Japan. uo@ims.ac.jp
Nakai
Yasushi
Y
D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004787:Environmental Pollution / Q000517:prevention & control; D010165:Palladium / Q000737:chemistry; D012117:Resins, Synthetic / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water
D001713:Biphenyl Compounds; D012117:Resins, Synthetic; D013501:Surface-Active Agents; D014867:Water; D010165:Palladium