Transferrin-mediated iron acquisition by pathogenic Neisseria.
The pathogenic Neisseria have a siderophore-independent iron-uptake system reliant on a direct interaction between the bacterial cell and transferrin. In the meningococcus this uptake system is dependent on two surface-exposed transferrin-binding proteins. This short account will review our current knowledge of the transferrin-mediated iron-acquisition system of pathogenic Neisseria.
Metalloprotein Research Group, The Randall Centre for Molecular Mechanisms of Cell Function, King's College London, 3.6A New Hunt's House, Guy's Campus, London SE1 1UL, UK. robert.evans@kcl.ac.uk
R W
RW
Evans
J S
JS
Oakhill
D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D007501:Iron / Q000378:metabolism*; D009345:Neisseria meningitidis / Q000378:metabolism* / Q000472:pathogenicity; D011990:Receptors, Transferrin / Q000737:chemistry / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*; D033863:Transferrin-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D014774:Virulence
D011990:Receptors, Transferrin; D014168:Transferrin; D033863:Transferrin-Binding Proteins; D007501:Iron