Measurement of enantiomeric excess using molecularly imprinted polymers.
[reaction: see text] A new method is presented for the measurement of enantiomeric excess (ee) utilizing molecularly imprinted polymers (MIPs). The method is demonstrated to be accurate and rapid, as the ee values can be calculated from straightforward concentration measurements. The MIP-based assay can also be adapted to measure the ee of samples of differing initial concentrations.
Chen
Yizhao
Y
University of South Carolina, Department of Chemistry and Biochemistry, Columbia, South Carolina 29208, USA.
Shimizu
Ken D
KD
D001665:Binding Sites; D002138:Calibration; D002846:Chromatography, Affinity; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism
D011108:Polymers; C060198:phenylalanine anilide; D010649:Phenylalanine