Chlamydia pneumoniae and hyperlipidemia are co-risk factors for atherosclerosis: infection prior to induction of hyperlipidemia does not accelerate development of atherosclerotic lesions in C57BL/6J mice.
Chlamydia pneumoniae has been shown to accelerate atherosclerotic lesion development in hyperlipidemic animals. This study showed that C. pneumoniae did not accelerate lesion development in mice if a high-fat/high-cholesterol diet was started after infection, indicating that C. pneumoniae is a co-risk factor with hyperlipidemia for cardiovascular disease.
Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA.
Erwin
E
Blessing
Lee Ann
LA
Campbell
Michael E
ME
Rosenfeld
Cho-chou
CC
Kuo
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D002690:Chlamydia Infections / Q000150:complications*; D016993:Chlamydophila pneumoniae / Q000472:pathogenicity*; D004036:Diet, Atherogenic; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012307:Risk Factors; D013997:Time Factors