[Malignant atrophic papulosis (Köhlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin].
A 45 year old female patient presented with the cutaneous manifestations of malignant atrophic papulosis (Köhlmeier-Degos disease) for two years. The typical papules with central porcelain-white atrophy correspond histologically to wedge-shaped necrosis of the connective tissue due to thrombotic occlusion of small vessels in the corium. The pathogenesis of malignant atrophic papulosis and effective treatment modalities are unknown. A slow virus infection has been suggested by some authors. Therefore, we attempted an immune therapy with interferon alpha-2a over a period of 11 months, but failed to cause a significant effect on the appearance and progression of the skin lesions. Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months.
Melnik
B
B
Dermatologie, Umweltmedizin und Gesundheitstheorie, Universität Osnabrück, Germany. Melnik@t-online.de
Hariry
H
H
Vakilzadeh
F
F
Gropp
C
C
Sitzer
G
G
D001241:Aspirin / Q000008:administration & dosage*; D001284:Atrophy; D003238:Connective Tissue / Q000098:blood supply / Q000473:pathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008875:Middle Aged; D010431:Pentoxifylline / Q000008:administration & dosage*; D011994:Recombinant Proteins; D012867:Skin / Q000098:blood supply / Q000473:pathology; D017444:Skin Diseases, Papulosquamous / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D017445:Skin Diseases, Vascular / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012897:Slow Virus Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013927:Thrombosis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D017211:Treatment Failure
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D001241:Aspirin; D010431:Pentoxifylline