[Cardiac toxicity of carbamazepine].
Carbamazepine toxicity on cardiovascular system in the course of acute poisonings and long term therapy are observed rarely. It's toxic influence on action potential in Purkinje fibres and 4 depolarization phase expresses clinically as the His bundle and atrioventricular blocks especially in patients with cardiologic disturbances. We present case of 64-year old woman with ischaemic heart disease poisoned with carbamazepine who died because of severe arrhythmias in the course of myocardial infarction during first 24 hours of intoxication. Heightened awareness of high risk lethal cardiovascular complications in patients intoxicated with carbamazepine with history of heart diseases is needed.
Oddział Chorób Zawodowych i Toksykologii im. Wandy Błeńskiej Zakład Opieki Zdrowotnej Poznań-Jezyce Szpital im. Franciszka Raszei 60-834 Poznań, ul. Mickiewicza 2. toksy@interia.pl
Dorota
D
Klimaszyk
Magdalena
M
Łukasik-GŁebocka
D002220:Carbamazepine / Q000009:adverse effects*; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D013406:Suicide, Attempted
D002220:Carbamazepine