Immunotherapy as a means to induce transplantation tolerance.
There have been several recent advances in the use of immunotherapy to induce transplantation tolerance. These include newer and safer protocols to create hematopoietic chimerism, the development of more-powerful T cell depleting antibodies, the identification of additional costimlulatory pathways as molecular targets and the identification of a role for suppressor cells in transplant tolerance.
Adler
Scott H
SH
University of Pennsylvania Department of Medicine, Renal-Electrolyte and Hypertension Division, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA. shadler@mail.med.upenn.edu
Turka
Laurence A
LA
D000069594:Abatacept; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000627:therapeutic use; D023201:CD40 Ligand / Q000502:physiology; D060908:CTLA-4 Antigen; D006801:Humans; D007108:Immune Tolerance; D018796:Immunoconjugates; D007165:Immunosuppression Therapy / Q000379:methods*; D007167:Immunotherapy / Q000379:methods*; D008212:Lymphocyte Depletion; D014181:Transplantation Immunology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018796:Immunoconjugates; D023201:CD40 Ligand; D000069594:Abatacept