Two mechanisms of protracted reaction times mediated by dissociable cortical networks.
When people divide attention between two sensory modalities and respond rapidly to stimuli in either modality, the reaction times (RTs) are longer than when they selectively attend and respond to one sensory modality. There is a further increase in RT when subjects use different fingers to respond to stimuli from different modalities as compared to when they use the same finger for both modalities. Here we use functional magnetic resonance imaging to show that division of attention bilaterally activates the caudal prefrontal areas near the precentral sulcus and areas in the intraparietal sulcus. All RT tasks, whether different fingers for different modalities or one finger for both modalities was used, activated identical motor areas 4a, 4p, supplementary and cingulate, the basal ganglia and the ventral anterior thalami. The increased blood oxygen level-dependent signal from motor cortical areas was anatomically distinct from the prefrontal/parietal areas. These anatomically dissociable neural substrates of division of attention and motor control may be responsible for the different types of RT delays that we have found. In the brain, there were no differences in the BOLD signal irrespective of whether the effector was specified a priori or was specified only after the sensory signal was received.
Herath
Priyantha
P
Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, 171 77, Sweden. Priyantha.Herath@neuro.ki.se
Young
Jeremy
J
Roland
Per
P
D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D009068:Movement / Q000502:physiology; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D010775:Photic Stimulation; D010812:Physical Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012677:Sensation / Q000502:physiology*