Schizopeptin 791, a new anabeanopeptin-like cyclic peptide from the cyanobacterium Schizothrix sp.
Schizopeptin 791 (1), a new trypsin inhibitor, related in structure to the anabeanopeptins, was isolated from the hydrophilic extract of the cultured terrestrial cyanobacterium Schizothrix sp. Homo- and heteronuclear 2D NMR techniques as well as HRFABMS determined the gross structure of 1. The relative and absolute stereochemistry of 1 was deduced from a combination of spectral data and Marfey's method for HPLC. Prior to this finding, anabeanopeptins have been isolated only from water-bloom-forming strains of cyanobacteria.
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Israel.
Vered
V
Reshef
Shmuel
S
Carmeli
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D007557:Israel; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D010456:Peptides, Cyclic; D014361:Trypsin Inhibitors; C466482:schizopeptin 791