Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts.
Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhibitors (e.g., transforming growth factor-beta), and genes controlling apoptosis (e.g., bax). A significant increase in DNA synthesis and intracellular mitogenic second messenger formation matched the high expression of MAP kinase family genes. These findings show that these electromagnetic fields have significant biological effects on human skin fibroblasts.
Pacini
Stefania
S
Department of Human Anatomy, Histology and Forensic Medicine, University of Firenze, Italy.
Ruggiero
Marco
M
Sardi
Iacopo
I
Aterini
Stefano
S
Gulisano
Franca
F
Gulisano
Massimo
M
D002453:Cell Cycle / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D002460:Cell Line; D040421:Cell Phone; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects / Q000648:ultrastructure; D005786:Gene Expression Regulation / Q000528:radiation effects*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011846:Radio Waves; D012867:Skin / Q000166:cytology* / Q000528:radiation effects / Q000648:ultrastructure