Estimating risk and rate levels, ratios and differences in case-control studies.
Classic (or 'cumulative') case-control sampling designs do not admit inferences about quantities of interest other than risk ratios, and then only by making the rare events assumption. Probabilities, risk differences and other quantities cannot be computed without knowledge of the population incidence fraction. Similarly, density (or 'risk set') case-control sampling designs do not allow inferences about quantities other than the rate ratio. Rates, rate differences, cumulative rates, risks, and other quantities cannot be estimated unless auxiliary information about the underlying cohort such as the number of controls in each full risk set is available. Most scholars who have considered the issue recommend reporting more than just risk and rate ratios, but auxiliary population information needed to do this is not usually available. We address this problem by developing methods that allow valid inferences about all relevant quantities of interest from either type of case-control study when completely ignorant of or only partially knowledgeable about relevant auxiliary population information.
Department of Government, Harvard University, Global Programme on Evidence for Health Policy, World Health Organization, Center for Basic Research in the Social Sciences, 34 Kirkland Street, Harvard University, Cambridge, MA 02138, USA. King@Harvard.edu
Gary
G
King
Langche
L
Zeng
D002318:Cardiovascular Diseases / Q000453:epidemiology; D016022:Case-Control Studies; D003198:Computer Simulation; D015658:HIV Infections / Q000150:complications; D006801:Humans; D018410:Pneumonia, Bacterial / Q000150:complications; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D013223:Statistics as Topic / Q000379:methods*