Changes in mRNA for VAMPs following facial nerve transection.
Vesicle-associated membrane proteins (VAMPs) are involved in synaptic vesicle recycling and exocytosis in neurons. Here we report the changes in mRNA expression for VAMPs (VAMP1, -2 and -3) in the facial motor nucleus of adult rats following axotomy by in situ hybridization. Signals for VAMP2 and -3 mRNAs in the facial nucleus were increased from 3 to 28 days after axotomy. On the contrary, VAMP1 mRNA, which was abundantly expressed in the control facial nucleus, was transiently decreased from 3 to 21 days after axotomy. Differential regulation of VAMPs may reflect distinct roles in nerve regeneration.
Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan.
Yong Ho
YH
Che
Toshihide
T
Yamashita
Masaya
M
Tohyama
D000818:Animals; D019771:Axotomy / Q000706:statistics & numerical data; D005154:Facial Nerve / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D009416:Nerve Regeneration / Q000502:physiology*; D050683:R-SNARE Proteins; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008565:Membrane Proteins; D050683:R-SNARE Proteins; D012333:RNA, Messenger