Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis.
A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.
Department of Hematology, Toranomon Hospital, Tokyo, Japan.
T
T
Hamaki
H
H
Katori
M
M
Kami
T
T
Yamato
H
H
Yamakado
T
T
Itoh
E
E
Kusumi
M
M
Igarashi
J
J
Ueyama
Y
Y
Kanda
S
S
Miyakoshi
S
S
Mineishi
S
S
Morinaga
M
M
Mukai
M
M
Hayashi
Y
Y
Takaue
S
S
Hara
Y
Y
Mutou
D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000633:toxicity; D003428:Cross Infection / Q000517:prevention & control; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D015182:Lymphatic Irradiation; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000150:complications / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous
D008558:Melphalan