Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells.
The adult retina is organized into three cellular layers--an outer photoreceptor, a middle interneuron and an inner retinal ganglion cell (RGC) layer. Although the retinal pigment epithelium (RPE) and Müller cells are important in the establishment and maintenance of this organization, the signals involved are unknown. Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina.
Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Ya Ping
YP
Wang
Gabriel
G
Dakubo
Paul
P
Howley
Katrina D
KD
Campsall
Chantal J
CJ
Mazarolle
Sarah A
SA
Shiga
Paula M
PM
Lewis
Andrew P
AP
McMahon
Valerie A
VA
Wallace
D000818:Animals; D019521:Body Patterning / Q000187:drug effects / Q000235:genetics*; D002450:Cell Communication / Q000187:drug effects / Q000235:genetics*; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics*; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology; D053823:Hedgehog Proteins; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010641:Phenotype; D011993:Recombinant Fusion Proteins / Q000494:pharmacology; D012160:Retina / Q000002:abnormalities* / Q000166:cytology / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D015534:Trans-Activators / Q000172:deficiency* / Q000235:genetics / Q000494:pharmacology
D006133:Growth Substances; D053823:Hedgehog Proteins; D011993:Recombinant Fusion Proteins; D015534:Trans-Activators