Relaxation induced by milrinone and rolipram in human penile arteries and veins.
We studied the relaxant effects of milrinone, an inhibitor of phosphodiesterase 3, and rolipram, an inhibitor of phosphodiesterase 4, on contracted human penile dorsal artery and deep dorsal vein. Vascular rings from 12 multi-organ donors were suspended in organ baths for isometric recording of tension. Both milrinone and rolipram inhibited (100%) the contraction induced by noradrenaline and shifted the relaxation-response curves to the cAMP forming agents prostaglandin E(1) and forskolin to the left. The findings indicate that the cAMP pathway appears to be a main determinant of relaxation in human penile vessels.
Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, School of Medicine, Blasco Ibáñez, 17, 46010, Valencia, Spain. gsegarra@post.uv.es
Gloria
G
Segarra
Pascual
P
Medina
José M
JM
Vila
Juan B
JB
Martinez-León
Cristina
C
Domenech
Fernando
F
Prieto
Salvador
S
Lluch
D000328:Adult; D002648:Child; D005576:Colforsin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D020105:Milrinone / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010413:Penis / Q000098:blood supply; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D020889:Rolipram / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*
D010726:Phosphodiesterase Inhibitors; D005576:Colforsin; D020105:Milrinone; D020889:Rolipram