Pro-inflammatory and anti-inflammatory cytokine increases after spinal instrumentation surgery.
We investigated the effects of instrumentation on postoperative inflammatory reaction and identified standard changes in serum cytokine concentrations after spinal surgery. Pro-inflammatory cytokines [interleukin (IL)-6 and IL-8] and anti-inflammatory cytokines [IL-10, IL-1 receptor antagonist (ra), and soluble tumor necrosis factor receptors (sTNF-R) I and II] were assayed in serum from seven patients with lumbar spinal posterior decompression, six with spinal decompression and posterolateral fusion without instrumentation and seven with spinal decompression and posterolateral fusion with instrumentation. All cytokines after spinal instrumentation increased significantly more than in other groups on postoperative days 0 and 1. Seven days after SI, IL-6, -8, and -10 had normalized, but IL-1ra and sTNF-RI and sTNF-RII remained elevated. Both pro-inflammatory and anti-inflammatory cytokines were enhanced by implants in the acute phase, whereas only anti-inflammatory cytokines were enhanced by instruments in the subacute phase.
Department of Orthopaedic Surgery, Shinshu University, School of Medicine, Shinshu University Hospital, Matsumo-City, Nagano, Japan. jtaka@hsp.md.shinshu-u.ac.jp
Jun
J
Takahashi
Sohei
S
Ebara
Mikio
M
Kamimura
Tetsuya
T
Kinoshita
Hiromichi
H
Misawa
Mitsuhiko
M
Shimogata
Minoru
M
Tozuka
Kunio
K
Takaoka
D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D053590:Interleukin 1 Receptor Antagonist Protein; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D019736:Prostheses and Implants / Q000009:adverse effects*; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D012795:Sialoglycoproteins / Q000097:blood; D013122:Spinal Diseases / Q000097:blood* / Q000601:surgery*; D013123:Spinal Fusion; D013997:Time Factors
D015703:Antigens, CD; D016207:Cytokines; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6; D016209:Interleukin-8; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D012795:Sialoglycoproteins; D016753:Interleukin-10; D002097:C-Reactive Protein