Innate and acquired resistance to amebiasis in bangladeshi children.
Entamoeba histolytica infection and colitis occurred in 55% and 4%, respectively, of a cohort of Bangladeshi preschool children observed for 2 years. DNA typing demonstrated that infecting E. histolytica isolates were genetically diverse. Innate resistance to infection in children was linked to the absence of serum anti-trophozoite IgG. Most children who lacked serum anti-trophozoite IgG failed to develop it in response to a new infection. The serum anti-trophozoite IgG response clustered in families, which is consistent with genetic inheritance. Acquired resistance to infection was linked to intestinal IgA against the carbohydrate-recognition domain of the E. histolytica galactose N-acetyl-d-galactosamine lectin. This was associated with an 86% reduction in new infection over 1 year. Amebiasis is a common and potentially serious infection in children from Dhaka, and both innate and acquired immune responses limit infection.
Haque
Rashidul
R
Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. rhaque@icddrb.org
Duggal
Priya
P
Ali
Ibnekarim M
IM
Hossain
Mohammad Bakthiar
MB
Mondal
Dinesh
D
Sack
R Bradley
RB
Farr
Barry M
BM
Beaty
Terri H
TH
Petri
William A
WA
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis / Q000097:blood; D001459:Bangladesh / Q000453:epidemiology; D002675:Child, Preschool; D004748:Entamoeba histolytica / Q000254:growth & development / Q000276:immunology*; D004749:Entamoebiasis / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000097:blood; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D007413:Intestinal Mucosa / Q000276:immunology; D037102:Lectins / Q000276:immunology
D000913:Antibodies, Protozoan; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D037102:Lectins