New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities.
Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan.
Atta-Ur-Rahman
Muhammad Nadeem
MN
Akhtar
Muhammad Iqbal
MI
Choudhary
Yoshisuke
Y
Tsuda
Bilge
B
Sener
Assad
A
Khalid
Masood
M
Parvez
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D031410:Fritillaria / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D013256:Steroids