A combined effect of molecular electrostatic potential and N7 accessibility explains sequence-dependent binding of cis-[Pt(NH3)2(H2O)2]2+ to DNA duplexes.
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université René Descartes 45, rue des Saints-Pères, 75270 Paris, France.
Véronique
V
Monjardet-Bas
Miguel-Angel
MA
Elizondo-Riojas
Jean-Claude
JC
Chottard
Jirí
J
Kozelka
D001482:Base Composition; D001483:Base Sequence; D001665:Binding Sites; D002945:Cisplatin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D055672:Static Electricity
D009838:Oligodeoxyribonucleotides; D004247:DNA; D002945:Cisplatin