Effect of Helicobacter pylori eradication in the glycemia of children with type 1 diabetes: a preliminary study.
BACKGROUND
We previously reported that children with diabetes and Helicobacter pylori infection had higher levels of glycated hemoglobin (HbA1c) than uninfected peers. We sought to determine whether eradication of the infection could decrease their HbA1c level.


METHODS
Eight children with type 1 diabetes and H. pylori infection (cases) were treated to eradicate the infection. Cases were matched (2:1) with uninfected diabetic children (controls), and their HbA1c levels were monitored.


RESULTS
As previously described, cases started with higher HbA1c values than controls. More than 2 years after treatment, cases showed a decreasing trend and controls an increasing trend in HbA1c values. At the end of the study, cases and controls had comparable HbA1c values.


CONCLUSIONS
These data suggest that eradication of H. pylori infection in patients with type 1 diabetes might be associated with better control of glycemia.
Department of Pediatrics, Louisiana State University Medical Center and Children's Hospital, New Orleans 70118, USA.
Rodolfo E
RE
Bégué
Ricardo
R
Gómez
Terry
T
Compton
Alfonso
A
Vargas
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D017291:Clarithromycin; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis*; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008795:Metronidazole; D013997:Time Factors
D000900:Anti-Bacterial Agents; D017291:Clarithromycin; D006442:Glycated Hemoglobin; D008795:Metronidazole