FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system.
The Drosophila adult has a complex tracheal system that forms during the pupal period. We have studied the derivation of part of this system, the air sacs of the dorsal thorax. During the third larval instar, air sac precursor cells bud from a tracheal branch in response to FGF, and then they proliferate and migrate to the adepithelial layer of the wing imaginal disc. In addition, FGF induces these air sac precursors to extend cytoneme-like filopodia to FGF-expressing cells. These findings provide evidence that FGF is a mitogen in Drosophila, correlate growth factor signaling with filopodial contact between signaling and responding cells, and suggest that FGF can act on differentiated tracheal cells to induce a novel behavior and role.
Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA.
Makoto
M
Sato
Thomas B
TB
Kornberg
D000199:Actins / Q000378:metabolism; D000400:Air Sacs / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D000818:Animals; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology*; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D002630:Chemotactic Factors / Q000378:metabolism* / Q000494:pharmacology; D004330:Drosophila / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D029721:Drosophila Proteins; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism* / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases; D011554:Pseudopodia / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D011679:Pupa / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014132:Trachea / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism
D000199:Actins; D002630:Chemotactic Factors; D029721:Drosophila Proteins; D019476:Insect Proteins; D017468:Receptors, Fibroblast Growth Factor; C102644:bnl protein, Drosophila; D005346:Fibroblast Growth Factors; C102301:BTL protein, Drosophila; D011505:Protein-Tyrosine Kinases; C102667:htl protein, Drosophila