Effects of a monophasic pill containing 20 microg ethinylestradiol and 150 microg desogestrel on lipid metabolism in Thai women.
OBJECTIVE
To investigate the effects of a monophasic oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel (Mercilon) on lipid metabolism in Thai women.


METHODS
The study was carried out at the Family Planning Clinic of King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Twenty women of fertile age were enrolled and treated with the study oral contraceptives for 12 cycles. Lipid parameters were assessed before treatment and periodically during treatment.


RESULTS
There was a significant increase in triglyceride, high desity lipoprotein-cholesterol, apolipoproteins AI and AII. No significant changes were found in total cholesterol, low density lipoprotein-cholesterol and apolipoprotein B.


CONCLUSIONS
The effects of the oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel on lipid parameters in Thai women appear to be favorably beneficial.
Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Unnop
U
Jaisamrarn
Surasak
S
Taneepanichskul
Rachanee
R
Wongwathanavikromn
Damrong
D
Reinprayoon
D000293:Adolescent; D000328:Adult; D001055:Apolipoproteins B / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage*; D017135:Desogestrel / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D011446:Prospective Studies; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D013785:Thailand; D014280:Triglycerides / Q000378:metabolism
D001055:Apolipoproteins B; D003277:Contraceptives, Oral, Combined; D014280:Triglycerides; D004997:Ethinyl Estradiol; D017135:Desogestrel; D002784:Cholesterol