[Experimental study on immunization of mice with nucleic acid vaccine Sj31BIN combining IL-12 against Schistosoma japonicum].
Based on the anti-fecundity effect of Schistosoma japonicum nucleic acid vaccine Sj31BIN, we combined Sj31BIN with IL-12 in vaccination of mice to explore the role of IL-12 as an adjuvant. The result showed that immunization of the mice with Sj31BIN + IL-12 led to a significant decrease in adult worm recovery, a liver egg count reduction of 59.74%, an intestine egg count reduction of 59.60% and a liver surface egg granuloma reduction of 71.3%. In addition, vaccination of the mice with IL-12 alone also led to some but not significant decrease in adult worm recovery and the egg counts. It is concluded that Sj31BIN plus IL-12 induces significant anti-fecundity immunity.
Zeng
X Z
XZ
Department of Parasitology, Hunan Medical University, Changsha 410078.
Yi
X Y
XY
Zeng
X F
XF
Zhou
J C
JC
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D005260:Female; D018664:Interleukin-12 / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D010270:Parasite Egg Count; D011897:Random Allocation; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000517:prevention & control*; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology*
D000276:Adjuvants, Immunologic; D019444:Vaccines, DNA; D018664:Interleukin-12