Principles of microbial alchemy: insights from the Streptomyces coelicolor genome sequence.
The world's most creative producers of natural pharmaceutical compounds are soil-dwelling bacteria classified as Streptomyces. The availability of the recently completed Streptomyces coelicolor genome sequence provides a link between the folklore of antibiotics and other bioactive compounds to underlying biochemical, molecular genetic and evolutionary principles.
Thompson
Charles J
CJ
Biozentrum, University of Basel, Division of Molecular Microbiology, 70 Klingelbergstrasse, 4056 Basel, Switzerland. Charles-J.Thompson@unibas.ch
Fink
Doris
D
Nguyen
Liem D
LD
D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D010860:Pigments, Biological / Q000378:metabolism; D013302:Streptomyces / Q000166:cytology / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010860:Pigments, Biological