HIV-1 genetic diversity in Western Brittany, France.
We describe human immunodeficiency virus type 1 (HIV-1) diversity in Western Brittany, France, and trace the dissemination of HIV-1 non-B subtype infection. The strategy for HIV-1 subtyping used involved subtype specific enzyme immunoassays, heteroduplex mobility assays and phylogenetic analysis of the sequences of env encoding the V3 loop region. Samples were obtained from 567 patients: 465 (82%) were of subtype B and 66 (11.6%) were not (20 were subtype A, 11 subtype C, four subtype D, seven subtype F, five subtype G and 19 others with circulating recombinant forms: 4CRF01_AE, 11CRF02_AG, 1H, 3CRF11_cpx). These findings are consistent with other studies of French populations. There is an epidemiological correlation between subtype B and homosexual or heterosexual contamination in France and between non-B subtype and heterosexual contamination in Africa.
Vallet
Sophie
S
Laboratoire de Microbiologie, CHU Morvan, Brest, France. sophie.vallet@univ-brest.fr
Legrand-Quillien
Marie-Christine
MC
Roger
Christine
C
Bellein
Veronique
V
Perfezou
Pascale
P
de Saint-Martin
Luc
L
Garre
Michel
M
Brun-Vezinet
Francoise
F
Picard
Bertrand
B
D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005602:France / Q000453:epidemiology; D015752:Genes, env; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D010802:Phylogeny; D012703:Serotyping
D004279:DNA, Viral