[Concentration of C-reactive protein, procalcitonin and alpha-1-antitrypsin in blood of neonates and infants with signs of inflammation].
We determined the concentration of C-reactive protein (CRP), procalcilonin (PCT) and alpha-1-antitrypsin (AAT) in blood of neonates and infants with suspected infection. Investigations were carried out in 88 children. Increased concentrations of CRP (>5mg/L). procalcitonin (>0.5ng/ml) and AAT (> 200mg/dl) were observed in: CRP - 24%. PCT- 46%, AAT - 49% of neonates in 70, 60 and 70% of infants. We concluded, that the examined parameters are good and sensitive markers of inflammation in neonates and infants.
Zaklad Biochemii i Diagnostyki Laboratoryjnej, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211 Warszawa, Poland.
Teresa
T
Laskowska-Klita
Barbara
B
Czerwińska
D001424:Bacterial Infections / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000097:blood; D007232:Infant, Newborn, Diseases / Q000097:blood* / Q000175:diagnosis; D007249:Inflammation / Q000097:blood; D011498:Protein Precursors / Q000097:blood*; D012680:Sensitivity and Specificity; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D000515:alpha 1-Antitrypsin; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide