[Effect of gui xin tong on sorbitol and nerve conduction velocity in diabetic rats].
OBJECTIVE
To investigate the effect of Gui Xin Tong(GXT) on sorbitol and nerve conduction velocity in diabetic rats.


METHODS
The model rats suffering from diabetes were induced by STZ, and blood sugar levels above 16 mmol/L were chosen for observation. The rats were divided into GXT group, AG group and control group. The nerve conduction velocity, aldose reductase activity and sorbitol in STZ induced diabetic rats were investigated.


RESULTS
Compared with the control group GXT could increase the sciatic nerve conduction velocity significantly (P < 0.05), decrease the RBC and sciatic nerve, aldose reductase activity, and RBC-sorbitol content.


CONCLUSIONS
GXT has the effect of improving nerve conduction velocity significantly and reducing aldose reductase activity and sorbitol
Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730.
X
X
Liang
W
W
Hao
L
L
Jia
H
H
Xu
K
K
Zhang
S
S
Guo
H
H
Zhang
R
R
Sun
D000449:Aldehyde Reductase / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000503:physiopathology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D010946:Plants, Medicinal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000503:physiopathology*; D013012:Sorbitol / Q000097:blood*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013012:Sorbitol; D000449:Aldehyde Reductase