Is the relationship between spondyloarthropathy and Sjögren's syndrome in women coincidental? A study of 13 cases.
OBJECTIVE
To determine the prevalence of Sjogren's syndrome (SS) in women with spondyloarthropathy (SpA).


METHODS
Forty-one women with SpA manifesting as inflammatory back pain and/or peripheral arthritis were diagnosed as having ankylosing spondylitis, undifferentiated spondyloarthropathy, psoriatic arthritis, or enteropathic arthropathy based on accepted criteria. A validated questionnaire was used to look for sicca symptoms in the SpA group and in 102 controls with degenerative rheumatic diseases. Women with SpA and sicca symptoms and/or positive antinuclear antibodies (ANA) were investigated for SS by minor salivary gland biopsy. In the SpA group, the following tests were done: HLA B27; HLA DR, DQ; ENA; and serology for CMV, EBV, HIV, hepatitis B, and hepatitis C.


RESULTS
Thirteen women (31.7%) met European criteria for SS, compared to three (2.9%) of the controls. Of the 41 women with SpA, 16 (39%) were ANA-positive. ANA were detected in eight of the 16 (50%) patients with SS. HLA B27 was present in 11 of the 13 (84.6%) SS patients. HLA DR 04.04 and DQ 03.03 seemed more common in SS patients, but the difference was not statistically significant.


CONCLUSIONS
SS was far more common in the women with SpA (31.7%) than in the controls (2.9%), suggesting that the SpA-SS association may not be coincidental.
Scotto di Fazano
Claire
C
Department of Rheumatology and Therapeutic, University Hospital Dupuytren, Limoges, France.
Grilo
Rose-Marie
RM
Vergne
Pascale
P
Coyral
Damien
D
Inaoui
Richard
R
Bonnet
Christine
C
Bertin
Philippe
P
Trèves
Richard
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications*; D013122:Spinal Diseases / Q000150:complications* / Q000276:immunology
D000974:Antibodies, Antinuclear; D015796:HLA-B27 Antigen; D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen; D006684:HLA-DR Antigens