Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats.
The aim of this study was to evaluate the effect of multiple acamprosate (500.0 mg/kg, p.o.) administration on short-term memory, using the social recognition test in rats. Ifenprodil (1.0 mg/kg, i.p.), arcaine (5.0 mg/kg, i.p.) and spermidine (20.0 mg/kg, i.p.) were chosen as polyamine ligands and their action or interaction with acamprosate was also studied. The doses used did not show any sedative activity, which was assessed by measuring locomotor activity and the hypnotic effect of ethanol. The findings suggest that acute acamprosate treatment did not impair short-term memory. Multiple acamprosate and a single spermidine or arcaine administration led to better performance in the memory test, whereas no significant difference was observed in ifenprodil-treated rats. Co-administration of a single arcaine or spermidine dose with multiple acamprosate produced worse results. This means that the effect of repeated acamprosate administration can be changed by the co-administration of other polyamine ligands, so that care should be taken in interpreting.
Department of Pharmacology, K. Marcinkowski University of Medical Sciences in Poznan, Fredry 10, 61-701, Poznan, Poland.
Przemyslaw
P
Mikolajczak
Irena
I
Okulicz-Kozaryn
Ewa
E
Kaminska
Lidia
L
Niedopad
Anna
A
Polanska
Joanna
J
Gebka
D000077443:Acamprosate; D000284:Administration, Oral; D000818:Animals; D001645:Biguanides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects; D013095:Spermidine / Q000494:pharmacology; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D001645:Biguanides; D010880:Piperidines; D011073:Polyamines; D016194:Receptors, N-Methyl-D-Aspartate; D013654:Taurine; C006624:arcaine; D000077443:Acamprosate; C010739:ifenprodil; D013095:Spermidine