[Preeclampsia-eclampsia: a change in utero-placental microcirculation. Immunologic, histologic, and biochemical features].
BACKGROUND
To know the alterations in the microcirculation of the placenta, umbilical cord, as well as the immune and hemorrheologic disorders in preeclampsia-eclampsia.


METHODS
Two groups were conformed, 30 patients each, all of them with pregnancy of more than 24-week gestation. Group A included patients with preeclampsia-eclampsia and group B (control group) included women with normal pregnancy. In all patients determinations of levels of platelets, fibrinogen, antinuclear antibodies, IgG and IgM anticardiolipin, VDRL were made; clotting times were determined, and histopathologic analyses (placenta, umbilical cord and uterus-placenta membranes) were performed.


RESULTS
Platelet levels in the group A were normal in 40% and low in 60%. In group B they were normal in 83.3% and low in 16.7%. with p < 0.05. In group A fibrinogen was normal in 10% and high in 90%; in the group B it was normal in 62.1% and high 37.9%, with p < 0.05. In group A prothrombin time (PT) was normal in 40% and high in 60%; in group B it was normal in 76.7% and low in 23.3%, with p < 0.05. in group TPT was normal in 36.7% and high in 62.1%, with p > 0.05. VDRL was negative in the 100% of the women of group A and positive in the 3.3% of the controls with p > 0.05. The antinuclear antibodies were positive in 6.7% in group A, and in 23.3% in group B, p < 0.05. IgG anticardiolipin antibodies were negatives in the 100% in both groups and IgM antibodies were negative in 96.7% in the group B and 3.3% in group A, p > 0.05. Analysis of histopathologic and immune changes did not show statistic significance when comparing both groups.


CONCLUSIONS
Statistical and clinical significance was observed only in the hemorrheologic changes (PT, TPT, fibrinogen and platelets) and in the newborn weight.
Servicio de Medicina Interna, Hospital General de Pachuca, SSH.
Lilia Hortensia
LH
Zendejas Cervantes
Hilda
H
Romero Romero
Alejandro
A
Lechuga Martín del Campo
Diana
D
Lechuga Martín del Campo
Javier
J
de la Rosa Bayón
Ma Isabel
MI
Castrejón Vázquez
Alfonso Javier
AJ
Miranda Feria
D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D001780:Blood Coagulation Tests; D002308:Cardiolipins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004461:Eclampsia / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D005321:Extraembryonic Membranes / Q000473:pathology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008833:Microcirculation; D010298:Parity; D010713:Phosphatidylcholines / Q000097:blood; D010920:Placenta / Q000098:blood supply* / Q000473:pathology; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D014470:Umbilical Cord / Q000473:pathology; D014599:Uterus / Q000098:blood supply*
D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D002308:Cardiolipins; D010713:Phosphatidylcholines; C054448:VDRL antigen; D005340:Fibrinogen; D002784:Cholesterol