Transrectal core biopsy trauma may increase cell proliferation in prostate tumors.
Whilst analyzing the morphological effects of a 3-week dietary intervention in patients with prostate cancer, we made an unexpected observation to the effect that prostate biopsy trauma may, at least transiently, increase prostate tumor cell proliferation. Further studies are needed to evaluate the clinical significance of this observation.
Bergh
A
A
Department of Pathology, Umeå University, Umeå, Sweden. anders.bergh@pathol.umu.se
Bylund
A
A
Lundin
E
E
Hallmans
G
G
Stattin
P
P
D001707:Biopsy, Needle / Q000009:adverse effects*; D002455:Cell Division; D019587:Dietary Supplements; D004311:Double-Blind Method; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007529:Isoflavones; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology*; D048789:Phytoestrogens; D010865:Pilot Projects; D028321:Plant Preparations; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000178:diet therapy* / Q000473:pathology*; D018570:Risk Assessment; D016896:Treatment Outcome
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D017430:Prostate-Specific Antigen