[Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson's disease].
It was established, that serotonin and dopamine content and dopamine uptake by brain nerve endings under experimental parkinsonism are decreased. Nicotinamide nicotinoyl-GABA administration leads to normalization these parameters. It was shown that NAm was more effective on serotonin content while nicotinoyl-GABA on dopamine one. Dopamine uptake was impaired at experimental parkinsonism and partially was normalized by incubation with NAD (10(-6) M). Thus, NAm, nicotinoyl-GABA and NAD are involved in the regulation of brain neurotransmission under experimental parkinsonism and can be useful in treatment of Parkinson's disease.
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. kuch@biochem.kiev.ua
T M
TM
Kuchmerovs'ka
H V
HV
Donchenko
H I
HI
Fomenko
H V
HV
Chichkovs'ka
L V
LV
Pakirbaieva
A N
AN
Klymenko
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009536:Niacinamide / Q000494:pharmacology*; D010300:Parkinson Disease / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D009536:Niacinamide; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine