Quantitative LC/MS-MS determination of sulfonamides and some other antibiotics in honey.
A simple and rapid method was developed for the determination of 20 antibiotics (sulfonamides, tetacyclines, and flumequine) in honey by liquid chromatography tandem mass spectrometry. The proposed method is sensitive (limit of detection 0.5 to 10 ppb for the various antibiotics) and selective. A hydrolysis step ensures the liberation of sugar-bound sulfonamides. The approach has been used to analyze some 300 honey samples. A number of them were found to have exceeded the Swiss limit of 50 ppb.
Official Food Control Authority of the Canton of Zurich (Kantonales Labor Zürich), Switzerland. anton.kaufmann@klzh.ch
Anton
A
Kaufmann
Sven
S
Roth
Bianca
B
Ryser
Mirjam
M
Widmer
Domink
D
Guggisberg
D000890:Anti-Infective Agents / Q000032:analysis* / Q000592:standards; D002853:Chromatography, Liquid / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D006722:Honey / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D012015:Reference Standards; D013449:Sulfonamides / Q000032:analysis* / Q000592:standards; D013557:Switzerland
D000890:Anti-Infective Agents; D013449:Sulfonamides