Synthesis and antiaggregant properties of Stabilized analogues of polyunsaturated fatty acid metabolites.
New aromatic and heteroaromatic analogues of polyunsaturated fatty acid metabolites have been prepared using short and versatile strategies. Preliminary studies of their activity as inhibitors of platelet aggregation are reported.
Hachem
Ali
A
ENSCR, Synthèses et Activations de Biomolécules, CNRS UMR 6052, Avenue du Gal Leclerc, 35700, Rennes, France.
Roussel
Patrick
P
Ménager
Eric
E
Grée
Danielle
D
Le Floc'h
Yves
Y
Grée
René
R
Cerletti
Chiara
C
Rolland
Yves
Y
Simonet
Serge
S
Verbeuren
Tony
T
D000818:Animals; D002478:Cells, Cultured; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits
D005231:Fatty Acids, Unsaturated; D010975:Platelet Aggregation Inhibitors