Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase.
Four N,N'-disubstituted perylene diimides, having different side chains, have been studied for their ability in inducing G-quadruplex DNA structures. We found that electrostatic interactions between ligands side chains and DNA grooves play a main role not only in the amount of G-quadruplex formed, but also in selecting its topology. Moreover, such compounds show also a different ability to inhibit telomerase. The correlation of these findings suggests the intriguing possibility that different G-quadruplex structures could differently inhibit the enzyme.
Dipartimento di Genetica e Biologia Molecolare, Fondazione Istituto Pasteur-Fondazione Cenci Bolognetti, Università di Roma 'La Sapienza', Piazzale A. Moro 5, 00185, Rome, Italy.
Luigi
L
Rossetti
Marco
M
Franceschin
Armandodoriano
A
Bianco
Giancarlo
G
Ortaggi
Maria
M
Savino
D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007094:Imides / Q000737:chemistry; D009690:Nucleic Acid Conformation; D010569:Perylene / Q000737:chemistry / Q000494:pharmacology*; D019098:Telomerase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D007094:Imides; D010569:Perylene; D004247:DNA; D019098:Telomerase