Synthesis of new 1-(but-2-ynyl)pyrazoles: containing a pyrrolidine or diethylamine moiety and their muscarinic properties.
The synthesis of two series of 1-(but-2-ynyl)pyrazole containing a pyrrolidine or a diethylamine moiety, respectively, is described, together with their muscarinic receptor affinities.
Rodríguez-Franco
María Isabel
MI
Instituto de Química Médica (C.S.I.C.), Madrid, Spain. IsabelRguez@iqm.csic.es
Dorronsoro
Isabel
I
Badía
Albert
A
Baños
Josep E
JE
D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D018721:Muscarinic Agonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000378:metabolism
D018721:Muscarinic Agonists; D011720:Pyrazoles; D011976:Receptors, Muscarinic