Reaction of glycosyl isothiocynates with 3-indolylaminomethyl-ketone hydrochloride.
Reaction of glycosyl isothiocyanate la-c with 3-indolylaminomethylketone hydrochloride(2) yielded glycosylthiourea derivatives 3a-c. Cyclodehydration of 3a-c with acetic anhydride afforded 5-(indol-3-yl)-2-[N-per-O-acetyl-D-glycopyranosyl)amino]thiazoles 4a-c. Deacetylation of 4a-c gave 5-(indol-3-yl)-2-[N-(D-glycopyranosyl) amino] thiazoles 5a-c.
Chemistry Department, Faculty of Science, Tanta University, Egypt. mahsaleh@hotmail.com
Mohamed A
MA
Saleh
D002712:Chlorides / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D017879:Isothiocyanates / Q000737:chemistry* / Q000378:metabolism; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis; D011487:Protein Conformation; D013055:Spectrophotometry, Infrared; D013696:Temperature
D002712:Chlorides; D017879:Isothiocyanates; D007659:Ketones; D009705:Nucleosides