Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure.
The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change MVO2 and LV mechanical efficiency increased (22.4+/-2.8% to 30.9+/-3.4% (P<0.05). In contrast, dobutamine significantly increased MVO2 and did not improve mechanical efficiency. Thus, short-term treatment with ranolazine improved LV function without an increase in MO2, resulting in an increased myocardial mechanical efficiency in dogs with HF.
Department of Medicine, Henry Ford Heart and Vascular Institute, Detroit, Mich 48202, USA.
Margaret P
MP
Chandler
William C
WC
Stanley
Hideaki
H
Morita
George
G
Suzuki
Bridgette A
BA
Roth
Brent
B
Blackburn
Andrew
A
Wolff
Hani N
HN
Sabbah
D000083:Acetanilides; D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D003326:Coronary Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D004280:Dobutamine / Q000008:administration & dosage; D004285:Dogs; D004334:Drug Administration Schedule; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D019344:Lactic Acid / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010879:Piperazines / Q000008:administration & dosage*; D000069458:Ranolazine; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy / Q000503:physiopathology
D000083:Acetanilides; D002316:Cardiotonic Agents; D005230:Fatty Acids, Nonesterified; D010879:Piperazines; D019344:Lactic Acid; D004280:Dobutamine; D000069458:Ranolazine; D005947:Glucose