Regulation of the vasculature: clues from lupus.
Blood vessel homeostasis involves a complex interplay between inflammatory signals, hormones, and other mediators. Recent research suggests that although atherosclerosis is primarily a problem of impaired lipid regulation, the very processes of cholesterol and triglyceride metabolism are intrinsically tied to inflammatory and hormonal regulatory signals. Similarities between inflammatory and endocrine disturbances in systemic lupus and the predicted consequences for vascular regulation help explain the high incidence of premature atherosclerosis in lupus. Atherosclerosis in systemic lupus, then, may be a consequence of imbalances in what are intrinsic homeostatic mechanisms, rather than a result of externally superimposed pathologic changes.
Merrill
Joan T
JT
Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA. joan-merrill@omrf.ouhsc.edu
D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D001808:Blood Vessels / Q000503:physiopathology*; D005260:Female; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D050356:Lipid Metabolism; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008297:Male
D018836:Inflammation Mediators