Solid-phase compound library synthesis in drug design and development.
This article is a subjective review of the literature between December 2000 and January 2002 related to the solid-phase synthesis of compound libraries for drug discovery and development. Examples of libraries yielding active compounds across a range of biological targets are presented, together with synthetic details where this is deemed of sufficient note. Background to the biological target and any structure-activity relationship, which can be discerned within members of a library series, is also discussed. A brief overview of new developments in solid-phase technology that is likely to impact upon drug discovery is also included.
Edwards
Paul J
PJ
Pfizer Global Research and Development, Library Design and Production Group, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK. paul_edwards@sandwich.pfizer.com
Morrell
Andrew I
AI
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D015195:Drug Design; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends