The genetic basis for psychiatric illness in man.
Following the influential genetic studies of Heston and Kety, there has been growing acceptance of the role of genes in determining behaviour. It is now recognized that most types of behaviour, from normal variations in traits such as personality to complex psychiatric disorders, are influenced not only by environmental factors but also by multiple genes. While twin and adoption studies have been vital in demonstrating the heritability of behaviour, the focus is now on the identification of the genes involved using the molecular genetic strategies linkage analysis and allelic association. This article will discuss techniques that have been used in psychiatric genetics, and how they have advanced our understanding of complex behaviour.
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, London SE5 8AF, UK. k.tandon@iop.kcl.ac.uk
Kopal
K
Tandon
Peter
P
McGuffin
D002874:Chromosome Mapping / Q000379:methods* / Q000639:trends; D004252:DNA Mutational Analysis / Q000379:methods*; D005787:Gene Frequency / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D008967:Molecular Biology / Q000379:methods* / Q000639:trends