[Inhibitory effect of paeonol on experimental atherosclerosis in quails].
OBJECTIVE
To study the effect of paeonol on experimental atherosclerosis in quails caused by high lipid feeding.


METHODS
The effects of oral administration of 300 and 600 mg/kg of paeonol on lipid levels in serum, hemorrheology and aortic intimal abnormalities were investigated.


RESULTS
Paeonol decreased TC, TG, LDL, vLDL, APOB100 levels in serum and TC levels in aorta and liver. The ratios of HDL/TC, HDL2/HDL3, apoA1/apoB100 were elevated. In addition, the drug reduced the whole blood viscosity, Plasma viscosity and plasma fibrinogen, and inhibited erythrocyte aggregation.


CONCLUSIONS
Oral administration of paeonol can reduce the development of atherosclerosis.
Dai
M
M
Anhui College of Traditional Chinese Medicine, Hefei 230038.
Zhi
X
X
Peng
D
D
Liu
Q
Q
D000098:Acetophenones / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000473:pathology; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011784:Quail; D014280:Triglycerides / Q000097:blood
D000098:Acetophenones; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D004365:Drugs, Chinese Herbal; D008077:Lipoproteins, LDL; D014280:Triglycerides; C013638:paeonol