Increased urine phenylethylamine after methylphenidate treatment in children with ADHD.
The urine levels of beta-phenylethylamine, 3-methoxy-4-hydroxyphenyl glycol, homovanillic acid, and 5-hydroxyindoleacetic acid were measured to clarify the neurochemical mechanism in attention deficit hyperactivity disorder. beta-Phenylethylamine levels were significantly lower in attention deficit hyperactivity disorder individuals (n = 37) than in controls (n = 21). The 22 children with attention deficit hyperactivity disorder were treated with methylphenidate, and they were further divided into methylphenidate responders (n = 18) and nonresponders (n = 4). beta-Phenylethylamine levels significantly increased after methylphenidate therapy in responders, whereas they did not increase in nonresponders.
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Japan.
Akira
A
Kusaga
Yushiro
Y
Yamashita
Tastuya
T
Koeda
Michio
M
Hiratani
Mika
M
Kaneko
Shigeto
S
Yamada
Toyojiro
T
Matsuishi
D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy* / Q000652:urine*; D001321:Autistic Disorder / Q000652:urine; D015415:Biomarkers; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008774:Methylphenidate / Q000627:therapeutic use*; D010627:Phenethylamines / Q000652:urine*; D011237:Predictive Value of Tests
D015415:Biomarkers; D000697:Central Nervous System Stimulants; D010627:Phenethylamines; D008774:Methylphenidate