The nitration of proteins in platelets: significance in platelet function.
Exogenous peroxynitrite has been shown to inhibit or activate platelets according to the concentration added and, at the same time, nitrate platelet proteins. Here, recent evidence is discussed which indicates that nitration of proteins may also occur during normal platelet activation by collagen, by mechanical stimulation during isolation and by exposure to low levels of hydrogen peroxide. Furthermore, this nitration appears to be transient. The implications of these findings are discussed in terms of platelet biology and cell signaling processes.
Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, University College London, London, UK.
Mojhgan
M
Sabetkar
Sylvia Y
SY
Low
Khalid M
KM
Naseem
K Richard
KR
Bruckdorfer
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism*; D030421:Peroxynitrous Acid / Q000494:pharmacology; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D015398:Signal Transduction; D013997:Time Factors; D014443:Tyrosine / Q000378:metabolism*
D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D014443:Tyrosine; D009584:Nitrogen