8-Aryl xanthines potent inhibitors of phosphodiesterase 5.
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in many cases, high levels of selectivity versus other PDE isoforms.
Arnold
Ruth
R
Novartis Horsham Research Centre, Wimblehurst Road, West Sussex RH12 5AB, Horsham, UK.
Beer
David
D
Bhalay
Gurdip
G
Baettig
Urs
U
Collingwood
Stephen P
SP
Craig
Sarah
S
Devereux
Nicholas
N
Dunstan
Andrew
A
Glen
Angela
A
Gomez
Sylvie
S
Haberthuer
Sandra
S
Howe
Trevor
T
Jelfs
Stephen
S
Moser
Heinz
H
Naef
Reto
R
Nicklin
Paul
P
Sandham
David
D
Stringer
Rowan
R
Turner
Katharine
K
Watson
Simon
S
Zurini
Mauro
M
D008958:Models, Molecular; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000187:drug effects*; D014970:Xanthines / Q000737:chemistry / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D010727:Phosphoric Diester Hydrolases