Assessment of repeatability and correlates of arterial compliance.
OBJECTIVE
The aim of these studies was to assess repeatability of large (C1) and small (C2) arterial elasticity indices over various time intervals using the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System (Hypertension Diagnostics, Inc., Eagan, Minnesota, USA). Non-invasive hemodynamic parameters using this device were compared to invasive measurements.


METHODS
After a 5-min period of rest, 31 healthy hospital employees underwent cardiovascular profiling on two occasions within 1 h apart. Another 59 healthy hospital employees underwent cardiovascular profiling on two occasions, an average 52 days apart. An additional group of 23 patients underwent right and left heart catheterizations for routine clinical indications and hemodynamic assessment was performed invasively and non-invasively.


RESULTS
For short-term repeatability, the mean difference of C1 was +0.25 +/- 2.83 ml/mmHg x 10 (P = NS) and C2 was -0.14 +/- 1.86 ml/mmHg x 100 (P = NS). For intermediate test repeatability, the mean difference of C1 was -0.415 +/- 2.97 ml/mmHg x 10 (P = NS) and C2 was -0.19 +/- 2.67 ml/mmHg x 100 (P = NS). In the invasive protocol, both aortic diastolic blood pressure (-4.74 +/- 9.7 mmHg) and systemic vascular resistance (-194 +/- 264 dyne x s x cm(-5)) were significantly lower invasively.


CONCLUSIONS
Measurements with the HDI/Pulsewave CR-2000 Research CardioVascular Profiling System are repeatable over both a short and intermediate period of observation. Furthermore, non-invasive hemodynamic parameters reasonably agree with invasive measurements.
Prisant
L Michael
LM
Hypertension and Clinical Pharmacology, Medical College of Georgia, Augusta 30912, USA. mprisant@mail.mcg.edu
Pasi
Mohit
M
Jupin
Dena
D
Prisant
Michelle E
ME
D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001827:Body Height; D001835:Body Weight; D006328:Cardiac Catheterization; D004548:Elasticity; D005260:Female; D005845:Georgia; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010564:Personnel, Hospital; D044469:Racial Groups; D015203:Reproducibility of Results; D013318:Stroke Volume; D014655:Vascular Resistance