[Fructose-bisphosphatase of microorganisms].
Data from modern scientific literature concerning general characteristics of fructose-bisphosphatase--the key enzyme of microorganisms gluconeogenesis pathway have been analyzed in the survey. The conditions of fructose-bisphosphatase functioning in the cell--activation and repression, have been described. Regulation of prokaryotes enzyme activity by fructose-1.6-bisphosphate, fructose-2.6-bisphosphate, phosphoenol pyruvate, metal cation, etc., is discussed. Absolute dependence of fructose-bisphosphatase activity on cations of bivalent metals (Mg2+, Mn2+) and AMP is shown. Special attention was given to the functioning and characteristics of the enzyme in prokaryotes and eukaryotes: their similarity and differences. Data about the basic enzyme of gluconeogenesis pathway in Gram-positive and Gram-negative microorganisms, conditions of its functioning in autotrophs and heterotrophs have been generalized for the first time. Genetical and molecular biological properties of fructose-bisphosphatase in microorganisms have been considered. At the same time, the fact is established that the above enzyme has not been investigated in numerous microorganisms.
Skrypal'
I G
IG
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
Iastrebova
O V
OV
D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000737:chemistry / Q000235:genetics; D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D005057:Eukaryotic Cells / Q000378:metabolism; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005943:Gluconeogenesis; D008969:Molecular Sequence Data; D011387:Prokaryotic Cells / Q000201:enzymology
D001426:Bacterial Proteins; D002352:Carrier Proteins; C112406:fibrinogen-binding protein, Streptococcus equi; D006597:Fructose-Bisphosphatase