Morphological changes in the sciatic nerve of diabetic rats treated with low molecular weight heparin OP 2123/parnaparin.
This study points out the early alterations that affect the sciatic nerve of rats with experimentally induced diabetes. It emphasizes the advantages deriving from treatment with low molecular weight heparin (LMWH) OP 2123/parnaparin and correlates these findings with observations emerging from a review of the relevant literature. In fact, the number and diameter of the capillaries within the sciatic nerve of diabetic rats appear to be increased consistent with a microangiopathy (the main characteristic of which is the fragility of new vessels), that is related to the evolution of diabetes in humans and animals. Our results suggest a possible therapeutic role for OP 2123/parnaparin in both diabetic neuropathy and microangiopathy, frequent complications of diabetes.
Artico
M
M
Human Anatomy, La Sapienza University of Rome, Italy.
Massa
R
R
Cavallotti
D
D
Franchitto
S
S
Cavallotti
C
C
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology* / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D003925:Diabetic Angiopathies / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control; D003929:Diabetic Neuropathies / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology* / Q000627:therapeutic use; D007091:Image Processing, Computer-Assisted; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; C080945:parnaparin