Dihydroquinolines as novel n-NOS inhibitors.
Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring.
Jaroch
Stefan
S
Department of Medicinal Chemistry, Corporate Research, Schering AG, D-13342-Berlin, Germany. stefan.jaroch@schering.de
Hölscher
Peter
P
Rehwinkel
Hartmut
H
Sülzle
Detlev
D
Burton
Gerardine
G
Hillmann
Margrit
M
McDonald
Fiona M
FM
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D011804:Quinolines; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I