Sustained drug release on temperature-responsive poly(N-isopropylacrylamide)-integrated hydroxyapatite.
A hybrid temperature-responsive hydroxyapatite-poly(N-isopropylacrylamide) (HAP-PNIPAAm) gel has been synthesized by the interpenetration of PNIPAAm into a sintered HAP disk through a radical-initiated polymerization of NIPAAm monomers under N2 atmosphere, and shows sustained positive thermo-responsive drug release profile over a month at PBS buffer.
Shin
Yongsoon
Y
Pacific Nortwest National Laboratory, P.O. Box 999, MSIN K2-44, Richland, WA 99352, USA. yongsoon.shin@pnl.gov
Liu
Jun
J
Chang
Jeong Ho
JH
Exarhos
Gragory J
GJ
D000180:Acrylic Resins / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002021:Buffers; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D006882:Hydroxyapatites / Q000737:chemistry*; D007213:Indomethacin / Q000493:pharmacokinetics*; D013499:Surface Properties; D013696:Temperature
D000180:Acrylic Resins; D001672:Biocompatible Materials; D002021:Buffers; D003692:Delayed-Action Preparations; D006882:Hydroxyapatites; C052970:poly-N-isopropylacrylamide; D007213:Indomethacin