The possible role of the cerebellum in autism/PDD: disruption of a multisensory feedback loop.
Autism and pervasive developmental disorder (PDD) are characterized by impairments in socialization and communication, and by restricted and stereotypic patterns of behavior. Associated symptoms or features of autism/PDD include problems with attention and orientation, and an odd response to the environment and sensory stimuli. Persons with autism/PDD can over or under respond or react to sensation. Evidence suggests that there is aberrant brain structure in this disorder, particularly in the cerebellum. This paper will attempt to show a possible relationship between the pathology in the cerebellum and the symptomatology seen in autism/PDD with an emphasis on the sensory issues.
Kern
J K
JK
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9101, USA. janet.kern@utsouthwestern.edu
D000328:Adult; D000344:Afferent Pathways / Q000503:physiopathology; D001321:Autistic Disorder / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D001931:Brain Mapping; D002452:Cell Count; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000648:ultrastructure; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D004192:Discrimination, Psychological / Q000502:physiology; D004525:Efferent Pathways / Q000503:physiopathology; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D008960:Models, Psychological; D011597:Psychomotor Performance / Q000502:physiology; D011689:Purkinje Cells / Q000473:pathology; D012678:Sensation Disorders / Q000503:physiopathology