Fas function and tumor progression: use it and lose it.
Recent studies have provided evidence that Fas and FasL interactions are important in the control of malignant disease and that changes in the level of Fas expression can determine immune escape and therapeutic responses.
Owen-Schaub
Laurie B
LB
Department of Biomedical Sciences, University of California, Riverside, Riverside, California 92521, USA. laurie.owen-schaub@ucr.edu
D000818:Animals; D017209:Apoptosis; D018450:Disease Progression; D053222:Fas Ligand Protein; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D019014:fas Receptor / Q000378:metabolism*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D019014:fas Receptor