Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries.
In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11>pinacidil>7>2>8>3>1>4>10>6>9>5>12.
Department of Cardiovascular Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Ocal
O
Berkan
Bülent
B
Saraç
Rahime
R
Simşek
Sahin
S
Yildirim
Yusuf
Y
Sarioğlu
Cihat
C
Safak
D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008970:Molecular Weight; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010656:Phenylephrine / Q000037:antagonists & inhibitors; D020110:Pinacidil / Q000494:pharmacology; D015221:Potassium Channels / Q000819:agonists*; D011817:Rabbits; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
D000166:Acridines; D007004:Hypoglycemic Agents; D015221:Potassium Channels; D013757:Tetraethylammonium Compounds; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D010656:Phenylephrine; D020110:Pinacidil; D005905:Glyburide