The effect of CoCl2 on xanthine oxidase, nitric oxide synthase, and protein kinase C activity as well as cytochrome P450 1A1, 1A2 and 1B1 quantities in rat liver.
Established that CoCl2 induced oxidative stress activates xanthine oxidase, inhibit nitric oxide synthase and cytochrome P450 in the rat liver in vivo. The concentration of S-nitrosothiols was respectively decreased and PKC was activated. The quantities of general cytochrome P450 as well as its 1A1, 1A2 and 1B1 isoforms were decreased.
Mechnikov Odessa National University. sumbayev@rambler.ru
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Yasinska
D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D018384:Oxidative Stress; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D026403:S-Nitrosothiols / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
D026403:S-Nitrosothiols; D017392:Thiobarbituric Acid Reactive Substances; D003035:Cobalt; D003577:Cytochrome P-450 Enzyme System; D019001:Nitric Oxide Synthase; D014969:Xanthine Oxidase; D011493:Protein Kinase C; C018021:cobaltous chloride