Risk factors for subsequent cervicovaginal human papillomavirus (HPV) infection and the protective role of antibodies to HPV-16 virus-like particles.
A high incidence of initial infection with human papillomavirus (HPV) was previously reported in a cohort of 608 women monitored at 6-month intervals for 3 years. Risk factors for subsequent infections with different HPV types and whether antibodies against HPV-16 virus-like particles (VLPs) protected against these infections were examined. Subsequent infections with HPV are very common. Seventy percent of women acquired a different HPV type within 24 months of the initial infection. Risk factors included being nonwhite, having an increased number of male sex partners, and having had a new male sex partner. Use of oral contraceptive pills was protective. A sustained high level of IgG antibody to HPV-16 VLPs was associated with reduced risk for subsequent infection with HPV-16 and its genetically related types (i.e., HPV-31, -33, -35, -52, and -58).
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. ho@aecom.yu.edu
Gloria Y F
GY
Ho
Yevgeniy
Y
Studentsov
Charles B
CB
Hall
Robert
R
Bierman
Leah
L
Beardsley
Michele
M
Lempa
Robert D
RD
Burk
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002584:Cervix Uteri / Q000821:virology*; D003276:Contraceptives, Oral; D005006:Ethnicity; D005260:Female; D005814:Genes, Viral; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000209:etiology* / Q000276:immunology* / Q000821:virology; D012307:Risk Factors; D012725:Sexual Behavior / Q000502:physiology; D012747:Sexual Partners; D014412:Tumor Virus Infections / Q000209:etiology* / Q000276:immunology* / Q000821:virology; D014621:Vagina / Q000821:virology*
D000914:Antibodies, Viral; D003276:Contraceptives, Oral