New approach to the stereoselective synthesis of metalated dienes via an isomerization-elimination sequence.
Treatment of Cp2ZrBu2 with enol ether containing a remote double bond lead to conjugated metalated diene as single isomer via a tandem isomerization-elimination sequence. 2-Arylsulfonyl 1,3-dienes can also be used as a source of dienyl zirconocene derivatives, and the stereochemistry of the diene is dependent on the transmetalation reaction.
Department of Chemistry and Institute of Catalysis Science and Technology, Technion-Israel Institute of Technology, Technion City, 32000 Haifa, Israel.
Nicka
N
Chinkov
Swapan
S
Majumdar
Ilan
I
Marek