Regulatory T cells in transplantation.
There has recently been an explosion of renewed interest in regulatory T cells, particularly those within the CD4(+)CD25(+) population. It is becoming increasingly apparent that these cells exist not only as naturally occurring cells that may contribute to the maintenance of self-tolerance, but they also have the potential to prevent rejection of allografts in experimental models. Such cells have now been identified in humans as well as in rodents.
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, UK. mkarim@doctors.org.uk
Mahzuz
M
Karim
Andrew R
AR
Bushell
Kathryn J
KJ
Wood
D000818:Animals; D016207:Cytokines / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D007376:Interleukin-2 / Q000502:physiology; D007519:Isoantigens / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*; D014181:Transplantation Immunology
D016207:Cytokines; D007376:Interleukin-2; D007519:Isoantigens; D015375:Receptors, Interleukin-2; D017493:Leukocyte Common Antigens