[Effects of Chinese patent medicine tongfugushen on adenine-induced chronic renal failure in rats].
OBJECTIVE
To observe the effects of Tongfugushen(TFGS) on adenine-induced chronic renal failure in rats.


METHODS
The model of chronic renal failure was made by feeding rats with food containing 0.5% adenine. Two weeks later, along with the above food, the treated group was administered the Chinese patent medicine TFGS, and the control group was given NS. Blood tests including urea nitrogen(BUN), serum creatinine(Scr), red blood cell(RBC), hemoglobin (Hb), hematocrit(HCT) and renal pathological tests were performed at the end of the fourth week.


RESULTS
In the TFGS treated group, the mean levels of BUN and Scr were lower and the mean values of RBC, Hb and HCT were higher than those in the control group, and the deposited crystals of adenine metabolite and the proliferation of fibroid tissue in kidney were decreased.


CONCLUSIONS
TFGS is helpful in improving the symptoms of chronic renal failure in rats.
Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515.
H
H
Deng
Y
Y
Chen
J
J
Chen
A
A
Yu
D000225:Adenine; D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007676:Kidney Failure, Chronic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D000225:Adenine