The treatment of parental height as a biological factor in studies of birth weight and childhood growth.
Parental height is frequently treated as a biological variable in studies of birth weight and childhood growth. Elimination of social variables from multivariate models including parental height as a biological variable leads researchers to conclude that social factors have no independent effect on the outcome. This paper challenges the treatment of parental height as a biological variable, drawing on extensive evidence for the determination of adult height through a complex interaction of genetic and social factors. The paper firstly seeks to establish the importance of social factors in the determination of height. The methodological problems associated with treatment of parental height as a purely biological variable are then discussed, illustrated by data from published studies and by analysis of data from the 1958 National Childhood Development Study (NCDS). The paper concludes that a framework for studying pathways to pregnancy and childhood outcomes needs to take account of the complexity of the relation between genetic and social factors and be able to account for the effects of multiple risk factors acting cumulatively across time and across generations. Illustrations of these approaches are given using NCDS data.
School of Postgraduate Medical Education, University of Warwick, Coventry CV4 7AL, UK. n.j.spencer@warwick.ac.uk
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D001724:Birth Weight / Q000235:genetics*; D001827:Body Height / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005220:Fathers / Q000706:statistics & numerical data*; D005260:Female; D006128:Growth / Q000235:genetics*; D006801:Humans; D008297:Male; D009035:Mothers / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012923:Social Class