Bcr-Abl variants: biological and clinical aspects.
Bcr-Abl is an oncogene that arises from fusion of the Bcr gene with the c-Abl proto-oncogene. Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias. Examination of the signaling pathways differentially regulated by the Bcr-Abl proteins will help us gain better insight into Bcr-Abl mediated leukemogenesis.
Advani
Anjali S
AS
Departments of Hematology and Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Pendergast
Ann Marie
AM
D016313:Genes, abl / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics; D010677:Philadelphia Chromosome; D000090063:Proto-Oncogene Mas