Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.
The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay. Generally, only a small proportion of prenatally exposed children are affected. The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome. The risk for recurrence in a subsequent pregnancy may be high and should be taken into account in the counseling of parents and in considering drug treatment.
Malm
H
H
Teratology Information Service, Department of Medical Genetics, Family Federation of Finland, Helsinki.
Kajantie
E
E
Kivirikko
S
S
Kääriäinen
H
H
Peippo
M
M
Somer
M
M
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis; D000015:Abnormalities, Multiple / Q000139:chemically induced* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000139:chemically induced* / Q000175:diagnosis; D004827:Epilepsy / Q000188:drug therapy; D005145:Face / Q000002:abnormalities*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D013577:Syndrome; D014635:Valproic Acid / Q000009:adverse effects*
D014635:Valproic Acid