Fatty acid composition of serum lipids in atopic and healthy dogs.
Fatty acids are increasingly used in the treatment of canine atopic dermatitis and their beneficial effects are documented in several prospective, controlled studies. Results from recent studies have indicated that atopic dogs have disordered fat metabolism, due to decreased desaturase activity. To further clarify these possible abnormalities, we examined serum fatty acid patterns in dogs with atopic dermatitis and normal controls. Atopic dermatitis was diagnosed according to the diagnostic criteria proposed by Willemse, after elimination of other possible causes of pruritic dermatitis. Both the relative and the absolute amounts of fatty acids in sera were determined by gas chromatography. Differences in the serum fatty acid pattern indicating a reduction in desaturase activity were not detected in atopic dogs when compared with controls.
Department of Small Animal Clinical Sciences, The Norwegian School of Veterinary Science, P.O. Box 8146, Dep., N-0033 Oslo, Norway. bente.k.saevik@veths.no
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Saevik
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Thoresen
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Taugbøl
D000818:Animals; D003876:Dermatitis, Atopic / Q000097:blood* / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D006262:Health; D008055:Lipids / Q000097:blood* / Q000737:chemistry*; D008297:Male
D005227:Fatty Acids; D008055:Lipids