[Familial transient red cell aplasia from parvovirus B-19 infection].
In our Paediatric Clinic we observed a case of transient aplastic crisis caused by Parvovirus B19 in a child and his mother, both affected by spherocytic haemolytic anemia. Anti-Parvovirus IgM antibody titre and viral search by PCR were positive. Anemia was treated with transfusion of concentrated red blood cells. In case of a family onset of hyperacute anemia it is necessary to consider a bone marrow aplastic crisis of the red series, induced by Parvovirus B19, especially if there is notice of an ongoing outbreak of erythema infectiosum.
Clinica Pediatrica dell'Università di Milano, Ospedale San Paolo, Via A. di Rudinì, 8, 20142 Milano. clinped@mailserver.unimi.it
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Salvini
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Tonella
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Carpani
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Zuccotti
D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D007231:Infant, Newborn; D008297:Male; D010322:Parvoviridae Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D012010:Red-Cell Aplasia, Pure / Q000235:genetics* / Q000821:virology*; D013103:Spherocytosis, Hereditary / Q000235:genetics*
D000914:Antibodies, Viral; D007075:Immunoglobulin M