A hepatitis B surface antigen mutant that lacks the antigenic loop region can self-assemble and interact with the large hepatitis delta antigen.
A novel hepatitis B virus surface antigen mutant harboring a deletion of most of the major antigenic loop region was competent for self-assembly and secretion. Although the mutant protein was competent for interaction with and incorporation of free large hepatitis delta antigen, it was partially defective in hepatitis delta virus RNP incorporation.
Department of Molecular Biology and Microbiology and the Raymond and Beverly Sackler Research Foundation Laboratory, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Brendan
B
O'Malley
David
D
Lazinski
D000595:Amino Acid Sequence; D018963:Hepatitis Antigens / Q000737:chemistry*; D006514:Hepatitis B Surface Antigens / Q000737:chemistry*; D003698:Hepatitis Delta Virus / Q000502:physiology*; D035923:Hepatitis delta Antigens; D008969:Molecular Sequence Data; D009154:Mutation; D012261:Ribonucleoproteins / Q000737:chemistry; D014771:Virion / Q000502:physiology*; D019065:Virus Assembly
D018963:Hepatitis Antigens; D006514:Hepatitis B Surface Antigens; D035923:Hepatitis delta Antigens; D012261:Ribonucleoproteins; C442244:hepatitis delta virus large antigen