[Blood coagulation factor XIII: activation, substrates and structure of a transglutaminase].
For a long time blood coagulation factor XIII did not get the attention it deserves, and research in the field of transglutaminases was neglected. The interesting results obtained in recent years demonstrate the importance of this protein for the stabilization of a blood clot. The accurate regulation of activation and of localization of factor XIII is not fully understood. Yet the proposed mechanisms suggest a high degree of complexity. In this review, recent biochemical and structural results on factor XIII are discussed.
Sicker
T
T
Institut für Molekulare Biotechnologie, Jena.
Hilgenfeld
R
R
D005176:Factor XIII / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D013379:Substrate Specificity; D011503:Transglutaminases / Q000378:metabolism*
D005176:Factor XIII; D011503:Transglutaminases