Caruncle tumor as the first sign of metastatic lung carcinoma.
OBJECTIVE
Report of a neuroendocrine carcinoma of the caruncle as the first sign of a metastatic lung carcinoma.


METHODS
Interventional case report.


METHODS
Excision of a rapidly growing caruncular tumor in a 76-year-old woman with a history of breast cancer.


RESULTS
Pathology revealed a large cell neuroendocrine carcinoma, consistent with metastatic lung carcinoma. Computerized tomography of chest, abdomen, and a bone scan disclosed signs of malignancy in the lungs, liver, and bones, originally considered as metastatic breast cancer. However, this diagnosis was excluded on the basis of histopathological findings and clonality analysis. A primary neuroendocrine (Merkel cell) carcinoma was ruled out on morphologic and immunohistochemical grounds.


CONCLUSIONS
We present a unique case of a metastatic large cell neuroendocrine carcinoma of the caruncle.
Lie
Angela
A
Rotterdam Eye Hospital, Oculoplastic Service & Pathology Service, The Netherlands.
Mooy
Cornelia
C
van den Bosch
Willem
W
Paridaens
Dion
D
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018287:Carcinoma, Large Cell / Q000737:chemistry / Q000556:secondary*; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000556:secondary*; D003230:Conjunctival Neoplasms / Q000737:chemistry / Q000556:secondary*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis
D014408:Biomarkers, Tumor; D016708:Synaptophysin