Polymeric membrane ion-selective electrode for determination of bismuth (III) in pharmaceutical substances.
A PVC-based membrane of tridecylmethylammonium chloride reveals a Nernstian potentiometric response (with slope of 55 mV/decade and a correlation coefficient of 0.99) for complex of bismuth (III) with ethylenediaminetetraacetate-anion [Bi(EDTA)](-) over a wide concentration range (1 x 10(-1) to 3 x 10(-5) mol/l). The potential of this electrode is independent of pH in the range of 4.0-11.0. It has a fast response time of about 30 s and was used for a period of 3 months with good reproducibility. The detection limit of this membrane electrode was 1 x 10(-5) M. This sensor exhibits a very good selectivity for [Bi(EDTA)] over a wide variety of complex metal ions with ethylenediaminetetraacetic acid. The proposed electrode has been used in the direct potentiometric monitoring of bismuth (III) in stomach anti-acids.
Kharitonov
Sergey
S
Department of Inorganic and Analytical Chemistry, Tver State University, P.O. Box 26144, Tver 170026, Russia. sergey.kharitonov@tversu.ru
D001729:Bismuth / Q000032:analysis* / Q000737:chemistry; D004492:Edetic Acid / Q000032:analysis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes / Q000706:statistics & numerical data; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000138:chemical synthesis; D011108:Polymers / Q000032:analysis / Q000737:chemistry
D004364:Pharmaceutical Preparations; D011108:Polymers; D004492:Edetic Acid; D001729:Bismuth