Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-Bissau.
OBJECTIVE
To evaluate the impact of Mycoplasma genitalium on the outcome of pregnancy.


METHODS
Cervical samples from women who had previously participated in a case-control study (designed to assess the impact of syphilis and HIV-2 on the outcome of pregnancy in Guinea-Bissau) were processed using a PCR assay to detect the presence of M genitalium. Controls were women who had delivered a term neonate with a birth weight over 2500 g. Cases were classified into four groups of mothers according to the outcome of pregnancy: stillbirths, spontaneous abortions, premature deliveries, and small for gestational age (SGA) babies.


RESULTS
Among the 1014 women included in this study, 6.2% were infected with M genitalium. M genitalium infection was not significantly associated with any of the adverse outcomes of pregnancy studied. Odds ratios (OR) for premature or SGA delivery in the presence of M genitalium infection were 1.37 (95% CI 0.69 to 2.60) and 0.44 (95% CI 0.01 to 2.75), respectively. For abortions and stillbirths, OR were respectively 0.61 (95% CI 0.07 to 2.51) and 1.07 (95% CI 0.42 to 2.42).


CONCLUSIONS
M genitalium appears not to have a deleterious impact on the outcome of pregnancy.
Centre for International Health, University of Sherbrooke, Canada. labbeac@yahoo.fr
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Labbé
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Frost
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Deslandes
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Mendonça
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Alves
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Pépin
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006169:Guinea-Bissau / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D009175:Mycoplasma Infections / Q000150:complications* / Q000453:epidemiology; D019535:Mycoplasma hominis / Q000302:isolation & purification; D010298:Parity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000382:microbiology*; D011256:Pregnancy Outcome; D015995:Prevalence; D002577:Uterine Cervical Diseases / Q000382:microbiology*