Profile of monocyte chemoattractant protein-1 circulating levels in gastric cancer patients.
BACKGROUND
Monocyte chemoattractant protein-1 (MCP-1) has been shown to act as a chemokine in the recruitment of monocyte/macrophages during inflammation states. It acts as an important factor in the cytokine network, which regulates tumor proliferation, whereas the association between serum MCP-1 level and gastric cancer has not yet been clarified.


METHODS
The serum concentration of MCP-1 in 76 gastric cancer patients and in 45 normal controls was determined using an immunoradiometric assay. The concentration of MCP-1 in the 47 cancer tissue samples was also determined.


RESULTS
The serum concentration of MCP-1 in patients with advanced carcinoma was significantly lower than that in controls. The serum concentration of MCP-1 in patients with advanced carcinoma was significantly lower than that in patients with early carcinoma. The serum concentration of MCP-1 was associated with clinicopathological factors including lymph node metastasis, serosal invasion and histological differentiation of the tumor. In patients who underwent palliative surgery, the serum MCP-1 level significantly decreased postoperatively, whereas in patients who underwent curative surgery the serum MCP-1 level tended to increase. The 4-year survival rate in patients whose serum MCP-1 levels were lower than or equal to the median value was significantly lower than that in patients whose MCP-1 levels were higher than the median value. The tissue concentration of MCP-1 in the cancer tended to decrease in accordance with disease progression.


CONCLUSIONS
The serum level of MCP-1 decreased in accord with disease progression, which reflects local consumption in gastric cancer. Serum MCP-1 may be a useful marker that reflects the host's local resistance to the tumor.
Dept of Innovative Surgery, Mie University Medical School, Tsu, Japan. tonouchi@clin.medic.mie-u.ac.jp
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Tonouchi
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Miki
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Tanaka
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Kusunoki
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D018932:Chemokine CCL2 / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005743:Gastrectomy; D006801:Humans; D015592:Immunoradiometric Assay; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000097:blood*; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D018932:Chemokine CCL2; D009363:Neoplasm Proteins