Detection and analysis of hepatitis C virus sequences in cerebrospinal fluid.
Hepatitis C virus (HCV) sequences were detected in cerebrospinal fluid (CSF) in 8 of 13 HCV-positive patients. In four patients harboring different virus strains in serum and peripheral blood mononuclear cells (PBMC), CSF-derived virus was similar to that found in PBMC, which suggests that PBMC could carry HCV into the brain.
Laskus
Tomasz
T
Division of Transplantation Medicine, Mayo Clinic, Scottsdale, Arizona 85259, USA.
Radkowski
Marek
M
Bednarska
Agnieszka
A
Wilkinson
Jeffrey
J
Adair
Debra
D
Nowicki
Marek
M
Nikolopoulou
Georgia B
GB
Vargas
Hugo
H
Rakela
Jorge
J
D020121:5' Untranslated Regions / Q000737:chemistry; D000328:Adult; D001483:Base Sequence; D002555:Cerebrospinal Fluid / Q000821:virology*; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid / Q000737:chemistry; D020133:Reverse Transcriptase Polymerase Chain Reaction
D020121:5' Untranslated Regions; D012367:RNA, Viral