[Opportunities of delayed densitometry of "late (fixed) contrast" as a test for tumors in residual mediastinal lesion in primary mediastinal lymphosarcoma after polychemotherapy].
OBJECTIVE
To clarify the potential of delayed densitometry of late (fixed) contrast in differentiation between tumor and fibrosis in residual mediastinal lesion (RML).


METHODS
Computed tomography (computed tomograph of the third generation COMATOM CR-3 made in Germany, SIEMENS) has examined 12 patients with mediastinal lymphosarcomas after polychemotherapy. All of them had a RML 3 to 6 cm in diameter.


RESULTS
CT has detected 8 cases of the tumor and 4 cases of fibrosis. The criteria of the tumor were the following: increased RML density shortly after the contrast medium introduction and 30 min after urographine introduction (p < 0.01); RML density 30 min after introduction of contrast medium was higher than above the aorta (p < 0.01). Fibrosis in RML was stated if RML density before, at the high of concentration and after introduction of the contrast medium was the same (p > 0.01); aortic density was significantly higher of RML density at the height of the contrast (p < 0.01).


CONCLUSIONS
The above method differentiates the tumor with fibrosis in RML with maximal probability. This facilitates further choice of therapeutic policy in secondary resistant form of primary mediastinal lymphosarcoma.
Dzhumabaeva
B T
BT
Gotman
L N
LN
Shavlokhov
B C
BC
Kaplanskaia
I B
IB
Margolin
O V
OV
Pivnik
A V
AV
Vishnevskaia
E S
ES
D000328:Adult; D003287:Contrast Media; D003937:Diagnosis, Differential; D003974:Diatrizoate Meglumine; D004358:Drug Therapy; D005355:Fibrosis / Q000000981:diagnostic imaging; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D018365:Neoplasm, Residual; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D003974:Diatrizoate Meglumine