Acetylated, methylated, remodeled: chromatin states for gene regulation.
The activity state of a gene is determined not only by sequence-specific regulatory factors but also by a complex network of co-acting proteins. Many of these proteins directly or indirectly affect the structure of the chromatin environment into which the gene is embedded. Recent studies of histone and DNA modifications support and refine the concept of the chromatin environment being key to the establishment and maintenance of transcriptional activity or repression.
Department of Molecular Biology, University of Innsbruck, Fritz-Pregl Strasse 3, A-6020 Innsbruck, Austria. alexandra.lusser@uibk.ac.at
Alexandra
A
Lusser
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000595:Amino Acid Sequence; D002843:Chromatin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D019175:DNA Methylation; D004734:Energy Metabolism; D018506:Gene Expression Regulation, Plant; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D010944:Plants / Q000235:genetics* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
D002843:Chromatin; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases