Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs.
The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mgkg(-1) b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t(1/2beta) was 271.3 min, V(d) 14.6 Lkg(-1), V(ss) 9.7 Lkg(-1) and CL 26.8 mLmin(-1)kg(-1). After i.m. administration, a C(max) of 1 microgmL(-1) was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%.
Departament de Farmacologia, Terapèutica i Toxicologia, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain. carme.prats@uab.es
C
C
Prats
G
G
El Korchi
R
R
Francesch
M
M
Arboix
B
B
Pérez
D000818:Animals; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006262:Health; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008657:Metabolic Clearance Rate; D013552:Swine / Q000378:metabolism*; D014018:Tissue Distribution; D015645:Tylosin / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D015645:Tylosin