[Center of multidrug-resistant malaria in a forest zone of Cameroon revisited after 14 years].
In vitro sensitivity of Plasmodium falciparum to chloroquine, amodiaquine, quinine and pyronaridine was assessed using the DELI microtest method in 2000. Isolates were collected on the La Nyé'eté rubber plantations located in a forest zone 45 km southeast of Kribi, Cameroon. Comparison with results of the last survey in 1986 showed that chloroquine resistance has remained stable (61% versus 56%). Sensitivity to amodiaquine and pyronaridine was high (76.5% and 89.5% respectively) in all isolates including chloroquine-resistant isolates. Despite intensive use in the area, quinine remained highly effective (sensitivity, 80%). These results indicate that chloroquine sensitivity has remained relatively stable in this resistant zone and that little cross-resistance with amodiaquine and pyronaridine has developed. These findings hold the promise for an alternative treatment of uncomplicated Plasmodium falciparum malaria in chloroquine-resistance areas.
Laboratoire de Parasitologie de la Faculté de Médecine et Pharmacie de Rouen, 22 boulevard Gambetta, 76183 Rouen, France. patrice.agnamey@wanadoo.fr
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Agnamey
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Moyou
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Galega
D000655:Amodiaquine / Q000627:therapeutic use; D000818:Animals; D002163:Cameroon / Q000453:epidemiology; D002738:Chloroquine / Q000627:therapeutic use; D018432:Drug Resistance, Multiple; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology*; D009287:Naphthyridines / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000627:therapeutic use; D014197:Trees
D009287:Naphthyridines; D000655:Amodiaquine; D002738:Chloroquine; D011803:Quinine; C027871:pyronaridine