Intragenomic conflict and cancer.
Intragenomic conflict occurs when some elements within the genome produce effects that enhance their own probability of replication or transmission at the expense of other elements within the same genome. Here it is proposed that mutations involved in intragenomic conflict are particularly likely to be co-opted by evolving lineages of cancer cells, and hence should be associated with the occurrence of cancer. We discuss several types of intragenomic conflict that are associated with various forms of cancer.
Summers
K
K
Department of Biology, East Carolina University, Greenville, NC 27858, USA. summersk@mail.ecu.edu
da Silva
J
J
Farwell
M
M
D003593:Cytoplasm / Q000378:metabolism; D004251:DNA Transposable Elements; D015894:Genome, Human; D018392:Genomic Imprinting; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D012730:Sex Chromosomes
D004251:DNA Transposable Elements; D006133:Growth Substances