Recommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group.
The National Heart, Lung, and Blood Institute (NHLBI) recently convened the Heart and Lung Xenotransplantation Working Group to identify hurdles to the clinical application of xenotransplantation, defined as the use of animal organs or tissue for transplantation, and to recommend possible solutions to these problems. The group consisted of experts in xenotransplantation from academia, industry, and federal agencies, and the discussions focused on those areas within the mission of the NHLBI. The areas covered included immunologic and physiological barriers to xenotransplantation, the limitations of the current animal models, the need for collaboration among groups, the high costs of studies using nonhuman primates and genetic engineering of pigs, and the unique problems of lung xenotransplantation. This report is a summary of those discussions.
Platt
Jeffrey
J
Department of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, Minn, USA.
DiSesa
Verdi
V
Gail
Dorothy
D
Massicot-Fisher
Judith
J
D000818:Animals; D006084:Graft Rejection; D000882:Haplorhini; D006287:Health Planning Guidelines; D016027:Heart Transplantation / Q000009:adverse effects / Q000191:economics / Q000592:standards / Q000639:trends; D006801:Humans; D007221:Industry / Q000191:economics; D017053:Infection Control; D016365:Liability, Legal; D016040:Lung Transplantation / Q000009:adverse effects / Q000191:economics / Q000592:standards / Q000639:trends; D023421:Models, Animal; D009316:National Institutes of Health (U.S.); D018570:Risk Assessment; D013552:Swine; D014183:Transplantation, Heterologous / Q000009:adverse effects / Q000191:economics / Q000592:standards / Q000639:trends; D014481:United States