[Effects of urapidil on cardiovascular response to tracheal intubation and incision during fentanyl co-induction].
To study the effects of urapidil (URA) on cardiovascular response to tracheal intubation and incision during fentanyl co-induction, forty-two patients (ASA I-II) were randomly divided into four groups: Group F1(n = 10), fentanyl 5 micrograms.kg-1 was given by venous injection; Group F2(n = 10), fentanyl 10 micrograms.kg-1; Group U1(n = 10), URA 0.25 mg.kg-1 plus fentanyl 5 micrograms.kg-1; Group U2(n = 12), URA 0.5 mg.kg-1 plus fentanyl 5 micrograms.kg-1. After tracheal intubation, mean arterial pressure (MAP), diastolic pressure (DP) in Group F1 and systolic pressure (SP) in Group U1 were increased more significantly than those in Group U2(P < 0.05). After incision, the values of SP, MAP, DP and rate-pressure product (RPP) in Group F1 were higher apparently than those in Group U2(P < 0.05); at the 5th minute, SP, MAP, heart rate (HR) and RPP in Group F1 were in higher than those in Group F2 (P < 0.05), and SP, MAP in Group U2 were lower than those in Group U1(P < 0.05). It is suggested that the cardiovascular response to tracheal intubation and incision may be effectively inhibited in combination URA with fentanyl, and the dosage of fentanyl might reduce.
Yang
H B
HB
Department of Anesthesiology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Cai
H W
HW
D018686:Anesthetics, Intravenous; D001649:Bile Duct Diseases / Q000503:physiopathology / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects*; D005283:Fentanyl; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D010879:Piperazines / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D010879:Piperazines; D014665:Vasodilator Agents; C015568:urapidil; D005283:Fentanyl