Arsenic keratosis and pigmentation accompanied by multiple Bowen's disease and genitourinary cancer in a psoriasis patient.
We report a case of arsenic keratosis and pigmentation accompained by multiple Bowen's disease and genitourinary cancer in a 64-year-old man. He was a psoriasis patient with a history of herbal medication for about thirty years. He showed multiple hyperkeratotic plaques on the bilateral palms, soles, and multiple, brownish, scaly, elevated papules on the back in addition to diffuse hyperpigmentation. Biopsy confirmed arsenic keratosis and Bowen's disease. Transitional cell carcinoma was also detected on his ureter and bladder during follow-up. The skin lesions were treated with topical 5-fluorouracil, etretinate, and excision with improvement.
Department of Dermatology, Seoul National University College of Medicine, Korea.
Je Young
JY
Park
Jong Hyun
JH
Rim
Yong Beom
YB
Choe
Jai Il
JI
Youn
D001151:Arsenic / Q000009:adverse effects*; D001913:Bowen's Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006229:Hand Dermatoses / Q000139:chemically induced; D006801:Humans; D007150:Immunohistochemistry; D007641:Keratolytic Agents / Q000008:administration & dosage; D007642:Keratosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery; D014565:Urogenital Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy
D007641:Keratolytic Agents; D001151:Arsenic