[Anti-inflammatory activity of (o-cresotinate) copper and zinc aquacomplexes].
Using rat paw dextran-induced and carrageenan-induced edemas, the antiedematous activities of monohydrate of the diaquatetrakis(o-cresotato)dicopper(II) complex (CuoC) and the diaquabis(o-cresotato)zinc(II) complex (ZnoC) were assayed plethysmometrically. Dihydrate of the diaquabis(salicylato)copper(II) complex (CuS) and the diaquabis(salicylato)zinc(II) complex (ZnS) were used as the standards of comparison. All compounds were administered i.p. in a single dose of 50 mumol/kg body weight (calculated for the RCOO-fragment) 30 min before injecting the irritants. The antidextran/anticarrageenan activities of the species (expressed as a mean edema reduction) were found: CuoC 36/54%--ZnoC 59/65%--CuS 71/52%--ZnS 63/10%. The relationships between the coordination-chemical properties and the biological effects of the corresponding complexes are discussed.
Sokolík
J
J
Katedra chemickej teórie lieciv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava. sokolik@fpharm.uniba.sk
Tumová
I
I
Blahová
M
M
Bernáthová
M
M
Svec
P
P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan; D003300:Copper / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D009942:Organometallic Compounds / Q000627:therapeutic use*; D051381:Rats; D015032:Zinc / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D009942:Organometallic Compounds; D003300:Copper; D002351:Carrageenan; D015032:Zinc