[Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson's disease].
It was established, that serotonin and dopamine content and dopamine uptake by brain nerve endings under experimental parkinsonism are decreased. Nicotinamide nicotinoyl-GABA administration leads to normalization these parameters. It was shown that NAm was more effective on serotonin content while nicotinoyl-GABA on dopamine one. Dopamine uptake was impaired at experimental parkinsonism and partially was normalized by incubation with NAD (10(-6) M). Thus, NAm, nicotinoyl-GABA and NAD are involved in the regulation of brain neurotransmission under experimental parkinsonism and can be useful in treatment of Parkinson's disease.
Kuchmerovs'ka
T M
TM
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. kuch@biochem.kiev.ua
Donchenko
H V
HV
Fomenko
H I
HI
Chichkovs'ka
H V
HV
Pakirbaieva
L V
LV
Klymenko
A N
AN
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009536:Niacinamide / Q000494:pharmacology*; D010300:Parkinson Disease / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D009536:Niacinamide; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine