The synthesis of substituted fluorenes as novel non-imidazole histamine h(3) inhibitors.
A novel non-imidazole fluorene oxime 1a has been identified as a histamine H(3) inhibitor, and its structure-activity relationship has been evaluated.
Ting
Pauline
P
The Schering Plough Research Institute, 2015 Galloping Hill Road, 07033, Kenilworth, NJ, USA. pauline.ting@spcorp.com
Lee
Joe
J
Albanese
Margaret
M
Tom
Wing
W
Solomon
Daniel
D
Aslanian
Robert
R
Shih
Neng
N
West
Robert
R
D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D013329:Structure-Activity Relationship
D005449:Fluorenes; D006634:Histamine H1 Antagonists; D018100:Receptors, Histamine H3