Severe Coxsackie virus B infection in preterm newborns treated with pleconaril.
Four preterm newborn infants with severe multisystem Coxsackie virus B infection were treated with an oral suspension of pleconaril (5 mg/kg per day). The patients had myocarditis, fulminant hepatitis, meningoencephalitis and disseminated intravascular coagulopathy. All four infants recovered, and no adverse effects of the treatment were noted.


CONCLUSIONS
pleconaril needs to be comprehensively evaluated in this population.
Neonatal Intensive Care Unit, Meir General Hospital, Kfar-Saba, The Sackler School of Medicine, Tel Aviv University, Israel.
Sofia
S
Bauer
Giora
G
Gottesman
Lea
L
Sirota
Ita
I
Litmanovitz
Shay
S
Ashkenazi
Itzhak
I
Levi
D000998:Antiviral Agents / Q000627:therapeutic use*; D003384:Coxsackievirus Infections / Q000188:drug therapy*; D004200:Diseases in Twins; D029822:Enterovirus B, Human / Q000187:drug effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010069:Oxadiazoles / Q000627:therapeutic use*; D010080:Oxazoles
D000998:Antiviral Agents; D010069:Oxadiazoles; D010080:Oxazoles; C115201:pleconaril