Integrin alpha(v)beta6-associated ERK2 mediates MMP-9 secretion in colon cancer cells.
There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin alpha(v)beta6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the beta6 integrin subunit and extracellular signal-regulated kinase 2. Targetting either beta6 or its interaction with extracellular signal-regulated kinase in order to inhibit matrix metalloproteinase activity may offer a useful therapeutic approach in preventing growth and spread of colon cancer.
Newcastle Bowel Cancer Research Collaborative, Hunter Medical Research Institute, John Hunter Hospital and The University of Newcastle, NSW 2308, Australia.
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Gu
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Niu
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Dorahy
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Scott
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Agrez
D000951:Antigens, Neoplasm; D001665:Binding Sites; D003110:Colonic Neoplasms / Q000201:enzymology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D019950:Mitogen-Activated Protein Kinase 1 / Q000502:physiology*; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D016023:Integrins; C073878:integrin alphavbeta6; D019950:Mitogen-Activated Protein Kinase 1; D020780:Matrix Metalloproteinase 9