Effects of DDT on paracetamol half-life in highly exposed mothers in Zimbabwe.
After assessment of the levels of DDT residues in the milk samples, 1 g paracetamol was administered p.o. to 28 breastfeeding mothers selected from a population of 116, according to DDT residues in their milk (the 14 with the highest values and the 14 least exposed). Post dose blood samples were taken from the basilic veins of the mothers at time intervals up to 4 h, post dose. The paracetamol blood concentrations were determined. A significantly shorter paracetamol half-life was found in mothers with higher DDT body burden, who also exhibited lower paracetamol concentrations in blood. The results highlighted concern for the highly exposed mothers taking paracetamol (NSAID) as an analgesic, or as an antipyretic.
Department of Clinical Pharmacology, School of Medicine, University of Zimbabwe, PO Box A 178, Avondale, Harare, Zimbabwe. ochikuni@healthnet.zw
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D000082:Acetaminophen / Q000493:pharmacokinetics*; D000293:Adolescent; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics*; D001942:Breast Feeding; D003634:DDT / Q000494:pharmacology*; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006207:Half-Life; D006801:Humans; D008895:Milk, Human / Q000737:chemistry; D015030:Zimbabwe
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D003634:DDT