Dicoumarol toxicity in cattle associated with ingestion of silage containing sweet vernal grass (Anthoxanthum odoratum).
A diagnosis of dicoumarol toxicity in a herd of Friesian cattle was made following investigation of the deaths of three mature cows and eleven yearling heifers. Affected stock had been fed wrapped, bailed silage containing approximately 90% sweet vernal grass (Anthoxanthum odoratum). Sweet vernal grass contains coumarin, which can be converted to dicoumarol, a vitamin K antagonist, through the action of moulds. Most deaths were preceded by lethargy, severe anaemia and subcutaneous and internal haemorrhage. Dicoumarol toxicosis was suspected based on clinical signs, necropsy findings and prolonged prothrombin and activated partial thromboplastin times. Dicoumarol analysis of blood from affected animals and silage confirmed the diagnosis. Activated partial thromboplastin time Haemoglobin Packed cell volume Prothrombin time Red cell count
Runciman
D J
DJ
Maffra Veterinary Centre, Victoria.
Lee
A M
AM
Reed
K F M
KF
Walsh
J R
JR
D000821:Animal Feed / Q000506:poisoning; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology*; D001728:Dicumarol / Q000097:blood / Q000506:poisoning*; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D008297:Male; D010939:Plant Poisoning / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D006109:Poaceae / Q000506:poisoning*; D014739:Victoria / Q000453:epidemiology
D001728:Dicumarol