Effect of ursodeoxycholate-3,7-disulfate on biliary excretion of lithocholate-3-O-glucuronide in Eisai hyperbilirubinemic rat (EHBR).
Biliary excretion of lithocholate-3-O-glucuronide and ursodeoxycholate-3,7-disulfate is markedly impaired in EHBR, in which the multidrug resistance protein 2 (Mrp2), a major ATP-dependent canalicular organic anion transporter, is impaired. We previously reported that biliary excretion of lithocholate-3-sulfate was enhanced by ursodeoxycholate-3,7-disulfate in Eisai hyperbilirubinemic rat (EHBR). In the present study, we examined the effect of ursodeoxycholate-3,7-disulfate infusion on biliary excretion of lithocholate-3-O-glucuronide. Although in control rats, ursodeoxycholate-3,7-disulfate infusion had no effect on biliary lithocholate-3-O-glucuronide excretion, in EHBR it enhanced biliary lithocholate-3-O-glucuronide excretion. These findings indicate that ursodeoxycholate-3,7-disulfate may interact to the excretory pathway of lithocholate-3-O-glucuronide and enhances biliary excretion of lithocholate-3-O-glucuronide in EHBR.
Department of Medicine, Teikyo University School of Medicine, Itabashi-ku, 173-8605, Tokyo, Japan
Yasumasa
Y
Hasegawa
Hajime
H
Takikawa