Discovering antimalarials: a new strategy.
Recent discoveries have uncovered some key processes that occur in the food vacuole of the malarial parasite. Consequently, new families of potential antimalarials that inhibit HRP-2, a hitherto unexplored drug target, were identified using a novel screening method.
Egan
Timothy J
TJ
Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa.
D000818:Animals; D000962:Antimalarials; D015195:Drug Design; D006801:Humans; D010963:Plasmodium falciparum / Q000737:chemistry / Q000502:physiology; D011506:Proteins / Q000037:antagonists & inhibitors; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors; D000099053:Histidine-Rich Glycoprotein
D000962:Antimalarials; D011506:Proteins; D015800:Protozoan Proteins; D000099053:Histidine-Rich Glycoprotein