Necrotizing granulomatous vasculitis associated with cocaine use.
Cocaine abuse may be associated with a destructive nasal and pharyngeal process felt to be due to ischemia secondary to vasoconstriction. This report is the first to document a necrotizing granulomatous vasculitis associated with nasal destruction and an oronasal fistula in a chronic cocaine user. Cocaine is an environmental insult that may play a role in triggering cerebral and non-cerebral vasculitis including a necrotizing granulomatous vasculitis of the respiratory tract.
Gertner
Elie
E
Department of Otolaryngology/Head and Neck Surgery, University of Minnesota Medical School, St. Paul, USA
Hamlar
Dave
D
D003042:Cocaine; D019970:Cocaine-Related Disorders / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D009336:Necrosis; D009668:Nose Diseases / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D016155:Oral Fistula / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D010256:Paranasal Sinuses / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery
D003042:Cocaine