[The protective effect of basic fibroblast growth factor (bFGF) and electroacupuncture on neurons against cerebral ischemia].
Transient cerebral ischemia/reperfusion rat model was adopted, and the method of HE staining, TUNEL staining (TdT-mediated dUTP Nick End Labeling) were used to observe the effect of electroacupuncture (EA) and basic fibroblast growth factor (bFGF) on neuronal death. The results evinced that the combination of EA and bFGF could evidently reduce the neuronal death, including both necrosis and apoptosis, compared with EA or bFGF application alone. It is suggested that bFGF and EA can complement each other and enhance the protective effect following cerebral ischemia.
National Key Laboratory of Medical Neurobiology, Institute of Acupuncture Research, Shanghai Medical College, Fudan University, Shanghai 200032.
Rong
R
Li
Jing-Chun
JC
Guo
Jie-Shi
JS
Cheng
D000818:Animals; D017209:Apoptosis; D002545:Brain Ischemia / Q000628:therapy*; D015671:Electroacupuncture; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D020287:In Situ Nick-End Labeling; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats
D018696:Neuroprotective Agents; D016222:Fibroblast Growth Factor 2