Biodegradable polymer networks based on oligolactide macromers: synthesis, properties and biomedical applications.
Novel linear and star-shaped oligolactide macromers were synthesized by ring-opening oligomerization of L-lactide in the presence of suitable initiators (di- and polyols, amino acid esters) and subsequent endgroup-functionalization of the formed oligolactides with methacrylate moities. The obtained liquid macromers are valuable building blocks for the preparation of biocompatible polymer networks. Based on these macromers, the fabrication and the material properties including biodegradation behaviour of highly porous polymer network devices will be described. The application of these materials as resorbable scaffolds in tissue engineering will be discussed.
Schnabelrauch
Matthias
M
INNOVENT Technologieentwicklung e. V., Prüssingstr. 27B, 07745 Jena, Germany. ms@innovent-jena.de
Vogt
Sebastian
S
Larcher
Yves
Y
Wilke
Ingo
I
D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry*; D002460:Cell Line; D006801:Humans; D046911:Macromolecular Substances; D008422:Materials Testing / Q000379:methods; D010006:Osteoblasts / Q000378:metabolism*; D011091:Polyesters / Q000737:chemistry* / Q000493:pharmacokinetics*; D011108:Polymers / Q000737:chemistry
D001672:Biocompatible Materials; D018786:Bone Substitutes; D046911:Macromolecular Substances; D011091:Polyesters; D011108:Polymers; C033616:poly(lactide)