[Neurochemical basis of ultra rapid opioid detoxication].
Ultra rapid opioid detoxification (UROD) is a new technique with the use of mu-opioid receptor antagonists to precipitate withdrawal. The scientific literature on UROD techniques in opiate addicts are reviewed, but little has been published on its neurochemical aspects. It is discussed that exposure to naloxone ore naltrexone during UROD is associated with development of increasing in opioidergic neurotransmission. On the other hand, ultra rapid opioid detoxification can be accompanied by normalization of joined brain neurotransmitter systems: noradrenergic, serotoninergic, GABAergic, cholinergic and glutamatergic neurotransmission systems. The neurochemical aspects of the new method detoxification are discussed.
Golovko
A I
AI
North-West Regional Therapeutic and Diagnostic Center Behterev, 6. Korabelnaja str., Saint Petersburg, 198096, Russia.
Leont'eva
L V
LV
Golovko
S I
SI
Zefirov
S Iu
SIu
Konoplin
D A
DA
Romanenko
O P
OP
D000818:Animals; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use; D009271:Naltrexone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D009293:Opioid-Related Disorders / Q000378:metabolism* / Q000628:therapy; D011957:Receptors, Opioid / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*; D009435:Synaptic Transmission / Q000187:drug effects*
D009292:Narcotic Antagonists; D018377:Neurotransmitter Agents; D011957:Receptors, Opioid; D009270:Naloxone; D009271:Naltrexone