Comparison of sensory testing on different toe surfaces: implications for neuropathy screening.
Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients with a broad range of diabetic sensorimotor neuropathy, we show that the predictive value of either test for diabetic sensorimotor neuropathy depends on the toe surface tested. These results establish the importance of standardized screening methods for diabetic sensorimotor neuropathy in the clinic and in clinical research trials.
Dimitrakoudis
Dimitri
D
University Health Network, Toronto General Hospital, University of Toronto, Ontario, Canada.
Bril
Vera
V
D048909:Diabetes Complications; D003929:Diabetic Neuropathies / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005189:False Positive Reactions; D006801:Humans; D008403:Mass Screening / Q000295:instrumentation / Q000379:methods*; D009460:Neurologic Examination / Q000295:instrumentation / Q000379:methods*; D011237:Predictive Value of Tests; D011312:Pressure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012684:Sensory Thresholds; D014034:Toes / Q000502:physiology / Q000503:physiopathology; D014110:Touch; D014732:Vibration