[Influence of functional groups of huatanyuxin decoction on Ca2+ transmembrane influx in rat aorta].
OBJECTIVE
To study the Ca2+ antagonistic effect of functional groups of Huatanyuxin decoction.


METHODS
The 45Ca transmembrane influx technique was used to measure the Ca2+ blocking effect of leak, receptor-operated Ca2+ channel (ROC) and potential-dependent Ca2+ channel (PDC) in rat aorta.


RESULTS
ROC and PDC could be blocked when the complex prescription was used at concentrations of 0.5-5 mg/ml. Among the functional groups, Huoxue group (activating blood) and Xinqi group (promoting and normalizing flow of vital energy) showed better Ca2+ antagonistic effect.


CONCLUSIONS
The mechanism of therapeutic effect of Huatanyuxin decoction may be related to its Ca2+ blocking effect similar to verapamil.
Institute of Nuclear Science and Technology, Sichuan Union University, Chengdu 610064.
S
S
Mo
N
N
Liu
J
J
Jin
W
W
Ding
X
X
Ruan
H
H
Qing
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats
D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; D002118:Calcium