Lipid peroxidation and antioxidant status in cervical cancer patients.
The present study examined the relationship between lipid peroxidation and antioxidant status in plasma, erythrocyte and erythrocyte membrane of cervical cancer patients and an equal number of age and sex matched normal subjects as well as patients with cervicitis. Lipid peroxidation was significantly increased with concomitant decrease in antioxidant levels in cervical cancer patients as compared to normal subjects and patients with cervicitis. The elevated lipid peroxidation and disturbed antioxidant status was also noticed in cervicitis patients as compared to normal subjects. This increase in lipid peroxidation can be attributed to possible breakdown of antioxidant mechanisms in cervicitis and cervical cancer patients.
Faculty of Science, Department of Biochemistry, Annamalai University, Tamil Nadu, India. manshi2001in@yahoo.com
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Manoharan
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Kolanjiappan
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Kayalvizhi
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Sethupathy
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008875:Middle Aged; D018384:Oxidative Stress; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D002575:Uterine Cervicitis / Q000378:metabolism
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances