14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin.
This paper describes the role 14-3-3 proteins play in vertebrate photoneuroendocrine transduction. 14-3-3 proteins form a complex with arylalkylamine N-acetyltransferase (AANAT), the enzyme which turns melatonin production on during the day and off at night. Complex formation is triggered at night by cAMP-dependent phosphorylation of the enzyme, and results in activation and protection against proteolysis. This enhances melatonin production >10-fold. Light exposure results in dephosphorylation of the enzyme and disassociation from 14-3-3, leading to destruction and a rapid drop in melatonin production and release and circulating levels.
Klein
D C
DC
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480, USA. klein@helix.nih.gov
Ganguly
S
S
Coon
S
S
Weller
J L
JL
Obsil
T
T
Hickman
A
A
Dyda
F
F
D048948:14-3-3 Proteins; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D002940:Circadian Rhythm / Q000502:physiology*; D008027:Light; D008550:Melatonin / Q000502:physiology*; D008958:Models, Molecular; D009490:Neurosecretory Systems / Q000502:physiology*; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000737:chemistry / Q000502:physiology*
D048948:14-3-3 Proteins; D014446:Tyrosine 3-Monooxygenase; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin