Ionic liquid acceleration of solid-phase suzuki-miyaura cross-coupling reactions.
[reaction: see text] Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects are translatable to solid-phase reactions. The Suzuki-Miyaura cross-coupling of 4-iodophenol immobilized on polystyrene-Wang resin with various arylboronic acids was significantly accelerated by the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF(4)(-)]).
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, United Kingdom.
Jefferson D
JD
Revell
A
A
Ganesan
D001881:Borates / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000592:standards*; D004787:Environmental Pollution / Q000517:prevention & control; D017743:Equipment Reuse; D007093:Imidazoles / Q000737:chemistry; D007220:Industrial Waste / Q000517:prevention & control*; D007462:Iodobenzenes / Q000737:chemistry; D007477:Ions; D010165:Palladium; D012117:Resins, Synthetic; D012997:Solvents
C419324:1-butyl-3-methylimidazolium tetrafluoroborate; D001881:Borates; D001897:Boronic Acids; D007093:Imidazoles; D007220:Industrial Waste; D007462:Iodobenzenes; D007477:Ions; D012117:Resins, Synthetic; D012997:Solvents; C050181:4-iodophenol; D010165:Palladium