[The expression and significance of VEGF mRNA and bFGF mRNA in the malignant neoplasms of ovary].
The expression and significance of VEGF mRNA and bFGF mRNA in the malignant neoplasms of ovary were studied by in situ hybridization technique. The results were that the positive rates of VEGF mRNA and bFGF mRNA were higher in the serous adenocarcinoma and embryonal carcinoma than that in the mucous adenocarcinoma and granulosa cell tumor. The positive rates of VEGF mRNA and bFGF mRNA were lower in the cases of clinical Stage I and without metastasis than that of clinical Stage III-IV and with metastasis. The results suggest that the expressions of VEGF mRNA and bFGF mRNA might be related to the pathological types, clinical stages, and metastasis of the malignant neoplasms of ovary and the patients who have positive expression of VEGF mRNA and bFGF mRNA might have a poor prognosis.
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics / Q000378:metabolism; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000235:genetics; D008222:Lymphokines / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2