Comparative in vitro activity of faropenem and 11 other antimicrobial agents against 405 aerobic and anaerobic pathogens isolated from skin and soft tissue infections from animal and human bites.
Faropenem, a new oral beta-lactam agent with a penem structure, was very active against 405 aerobic and anaerobic bite isolates. It inhibited 232 of 236 (98%) aerobic isolates, including all Pasteurella spp. and Eikenella corrodens at < or = 0.25 mg/L, and 164/169 (97%) anaerobic isolates, at < or = 1 mg/L. The 10 isolates that required > or = 2 mg/L for inhibition were one strain each of Acinetobacter lwoffi, Corynebacterium minutissimum, Bacteroides ovatus, Lactobacillus delbrueckii and Peptostreptococcus tetradius, plus Corynebacterium 'aquaticum' (two strains) and Veillonella sp. (three strains).
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center and the UCLA School of Medicine, Los Angeles, CA 90073, USA. EJCGMD@aol.com
Ellie J C
EJ
Goldstein
Diane M
DM
Citron
C Vreni
CV
Merriam
Yumi A
YA
Warren
Kerin L
KL
Tyrrell
Helen T
HT
Fernandez
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D001420:Bacteria, Aerobic / Q000187:drug effects* / Q000302:isolation & purification; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000382:microbiology*; D001733:Bites and Stings / Q000382:microbiology*; D024841:Fluoroquinolones; D006801:Humans; D007769:Lactams; D018942:Macrolides; D017192:Skin Diseases, Bacterial / Q000382:microbiology*; D013754:Tetracyclines; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007769:Lactams; D018942:Macrolides; D013754:Tetracyclines; D047090:beta-Lactams; C107057:fropenem