A randomized paired eye comparison of two techniques for treating moderately high myopia: LASIK and artisan phakic lens.
OBJECTIVE
To compare refractive performance and safety of laser in situ keratomileusis (LASIK) and Artisan phakic intraocular lens (PIOL) for moderately high myopia.


METHODS
A prospective, randomized trial with paired eye control.


METHODS
Twenty-five patients with myopia ranging from -8.00 to -12.00 diopters (D).


METHODS
For each patient, one eye received LASIK and the other one was implanted with an Artisan phakic intraocular lens. The treated eye and the surgical technique were randomized.


METHODS
Primary outcome measure was spherical equivalent refraction. Main secondary outcome measures were the change of two or more lines and safety index (ratio postoperative to preoperative best-corrected visual acuity).


RESULTS
One year after surgery, the mean spherical equivalent refraction was -0.74 +/- 0.67 D for LASIK-treated eyes and -0.95 +/- 0.45 D for Artisan-treated eyes, and the majority of LASIK-treated eyes (64%) and Artisan-treated eyes (60%) were within +/-1.00 D of the intended result. At 1 month, the mean spherical equivalent refraction was -0.28 +/- 0.71 D for LASIK and -1.07 +/- 0.59 D for Artisan (P < 0.01). The changes of two or more lines were in favor of Artisan (P < 0.05). The safety index was significantly better for Artisan (1.12 +/- 0.21) than for LASIK (0.99 +/- 0.17) at 1 year (P < 0.02).


CONCLUSIONS
In cases of moderately high myopia, LASIK and Artisan phakic intraocular lenses seemed to produce a similar predictability. The best-corrected visual acuity and subjective evaluation of quality of vision were better for Artisan.
Malecaze
François J
FJ
Service Ophtalmologie, Hôpital Purpan, Toulouse, France. INSERM U 558, Toulouse, France. malecaze.fr@chu-toulouse.fr
Hulin
Hervé
H
Bierer
Pascal
P
Fournié
Pierre
P
Grandjean
Hélène
H
Thalamas
Claire
C
Guell
José L
JL
D000328:Adult; D015350:Contrast Sensitivity; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007908:Lens, Crystalline / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular; D012449:Safety; D016896:Treatment Outcome; D015348:Vision, Binocular; D014792:Visual Acuity