[Clinical significance of erythrocyte ferritin in refractory anemia and chronic myeloid leukemia].
OBJECTIVE
To find out if the RBC ferritin elevation can serve as an additional criterion of inefficient erythropoiesis during progression of chronic myeloid leukemia (CML) and in various types of refractory anemia.


METHODS
The study group consisted of 56 MDS patients and 73 patients at various stages of CML. 20 healthy donors and 105 patients with verified inefficient erythropoiesis (20--with B12 deficiency before and after the treatment, 85--with beta-thalassemia) were the controls. A ferritin level was measured by radioimmunoassay in RBC hemolysates.


RESULTS
The RBC ferritin level in all types of refractory anemia was elevated throughout the disease course, increasing with the development of transfusion dependency. The CML progression was also accompanied by RBC ferritin level elevation associated with abnormal erythroid cell accumulation and elevation of intracellular PAS-positive substance (p < 0.05).


CONCLUSIONS
RBC ferritin level elevation can be considered as an additional biochemical criterion of inefficient erythropoiesis that may be useful in differentiation of anemias, adequate therapy selection and follow-up of erythropoiesis.
Tsvetaeva
N V
NV
Vinogradova
O Iu
OIu
Levina
A A
AA
Tsibul'skaia
M M
MM
Diagileva
O A
OA
Sokolova
M A
MA
Kuznetsov
S V
SV
Turkina
A G
AG
Khoroshko
N D
ND
D000328:Adult; D000368:Aged; D000753:Anemia, Refractory / Q000097:blood / Q000175:diagnosis*; D004912:Erythrocytes / Q000737:chemistry*; D004920:Erythropoiesis; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D005293:Ferritins