Molecular characterization confirms the presence of a divergent strain of canine coronavirus (UWSMN-1) in Australia.
Canine coronavirus (CCV) UWSMN-1 was originally identified from an outbreak of fatal gastroenteritis in breeding colonies. In this report, we examined whether UWSMN-1 represents a novel divergent strain or is the result of recombination events between canine and feline coronavirus strains. Sequencing of various regions of the spike and polymerase genes confirms that UWSMN-1 is widely divergent from other CCV and feline coronavirus strains. These data raise the possibility that this strain is the first member of a novel third subtype of CCV.
Naylor
Matthew J
MJ
School of Science, Food and Horticulture, University of Western Sydney, Penrith South DC, New South Wales, Australia. m.naylor@garvan.org.au
Walia
Charanjiv S
CS
McOrist
Steven
S
Lehrbach
Philip R
PR
Deane
Elizabeth M
EM
Harrison
Gavan A
GA
D000818:Animals; D001315:Australia; D001483:Base Sequence; D018352:Coronavirus Infections / Q000662:veterinary* / Q000821:virology; D017939:Coronavirus, Canine / Q000145:classification* / Q000235:genetics*; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D015751:Genes, pol / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics*
D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins