B-cell signaling: protein kinase Cdelta puts the brakes on.
The phenotype of mice lacking the delta isoform of protein kinase C reveals that this isoform curtails signaling events after engagement of the antigen-specific receptor on B cells. The result is a state of non-responsiveness, termed anergy, that represents one form of immunological self-tolerance.
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA. cbcm@joslin.harvard.edu
Diane
D
Mathis
George L
GL
King
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009113:Muramidase / Q000235:genetics / Q000276:immunology; D016328:NF-kappa B / Q000378:metabolism; D010641:Phenotype; D020033:Protein Isoforms / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011493:Protein Kinase C / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051745:Protein Kinase C-delta; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D007136:Immunoglobulins; D016328:NF-kappa B; D020033:Protein Isoforms; D011947:Receptors, Antigen, B-Cell; C497259:Prkcd protein, mouse; C497258:PRKCD protein, human; D011493:Protein Kinase C; D051745:Protein Kinase C-delta; C421864:hen egg lysozyme; D009113:Muramidase