Case report: somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma.
A 54-year-old woman presented with extremely fluctuating and symptomatic blood glucose levels. Very high levels of somatostatin and low levels of insulin, C-peptide, gastric inhibitory peptide (GIP), and glucagon-like peptide-1 (GLP-1) in peripheral blood were constantly present. A benign somatostatinoma was localized by meta-iodobenzyl guanidine iodine 123 (MIBG-I(123)) scintigraphy and successfully removed encapsulated in an ovarian teratoma. The patient made a complete recovery. The case described is unique with regard to clinical symptomatology and anatomic localization of the tumor.
Department of Endocrinology, Esbjerg Centralsygehus, Denmark.
Gunnar
G
Gregersen
J J
JJ
Holst
A
A
Trankjaer
F
F
Stadil
Anne M
AM
Mogensen
D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007003:Hypoglycemia / Q000209:etiology; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism*; D013004:Somatostatin / Q000096:biosynthesis*; D013005:Somatostatinoma / Q000473:pathology; D013724:Teratoma / Q000150:complications / Q000378:metabolism*
D001786:Blood Glucose; D013004:Somatostatin