Platelet collagen receptor GPIa (C807T/HPA-5) haplotype is not associated with an increased risk of fatal coronary events in middle-aged men.
Platelet GPIa/IIa receptors play key roles in the adhesion of platelets to collagen during the formation of coronary thrombosis. The C807T and HPA-5 polymorphisms of the gene for GPIa define three distinct alleles of GPIa which are associated with the surface expression of the protein in an allele-dependent fashion. Significance of these polymorphisms in victims of sudden cardiac death (SCD) was studied in Helsinki Sudden Death Study (HSDS) comprising 700 autopsied middle-aged Caucasian Finnish men with 288 SCD victims and 84 men with fatal acute myocardial infarction (AMI). The high-expression A1 allele was found in 36.6% of control men as opposed to 38.0% of all SCD victims and 36.9% of men with fatal AMI (P>0.4). The high-expression A1A1 genotype was found in 11.9% of men with fatal AMI and 10.0% of controls as opposed to the low-expression A2A2 genotype which was found in 29.8% of men with fatal AMI and in 31.2% of controls (OR 1.2, P>0.3). Age group (under/over 55) had no effect on the results. Our results do not support an effect of the GPIa haplotype on fatal coronary events among middle-aged men.
Mikkelsson
Jussi
J
Medical School/building B, University of Tampere and Tampere University Hospital, P.O. Box 607, FIN-33014 Tampere, Finland. jm56215@uta.fi
Perola
Markus
M
Penttilä
Antti
A
Karhunen
Pekka J
PJ
D000367:Age Factors; D000704:Analysis of Variance; D001344:Autopsy; D003328:Coronary Thrombosis / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D016757:Death, Sudden, Cardiac; D005387:Finland / Q000453:epidemiology; D005786:Gene Expression Regulation; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012494:Sampling Studies
D019038:Platelet Glycoprotein GPIb-IX Complex