Comparison of the significance of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon cuniculi infection.
The role of T lymphocyte subpopulations in the protection against intraperitoneal (i.p.) and peroral Encephalitozoon cuniculi infections was compared in adoptive-transfer experiments using severe combined immunodeficient mice. Whereas CD8+ T cell-depleted, but not CD4+ T cell-depleted, BALB/c splenocytes failed to protect the mice against i.p. infection, only SCID mice reconstituted with both CD4+ T lymphocyte- and CD8+ T lymphocyte-depleted splenocytes succumbed to peroral infection. The results indicate that whereas CD8+ T cells are critical for the protection against an i.p. E. cuniculi infection, both CD4+ and CD8+ T lymphocyte subpopulations play a substantive protective role in a peroral infection, i.e., natural route of infection.
Braunfuchsová
Pavlína
P
Institute of Parasitology, Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Branisovská 31, 370 05 Ceské Budĕjovice, Czech Republic.
Salát
Jirí
J
Kopecký
Jan
J
D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D009670:Encephalitozoon cuniculi; D016890:Encephalitozoonosis / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D013154:Spleen / Q000276:immunology