A case of Sézary's syndrome associated with granulomatous lesions, myelodysplastic syndrome and transformation into CD30-positive large-cell pleomorphic lymphoma.
Sézary's syndrome (SS) is a leukaemic variant of mycosis fungoides, a cutaneous T-cell lymphoma showing distinct clinical, histological, immunological, and genotypic features. We report a 10-year follow-up of a patient with SS exhibiting unusual features such as granulomatous skin lesions, transformation to a CD30-positive large-cell pleomorphic T-cell lymphoma, and development of myelodysplastic syndrome and review the cases of SS reported in the literature with these unusual and rare complications.
Carrozza
P M
PM
Department of Dermatology, University of Zurich Medical School, Gloriastr. 31, CH-8091 Zurich, Switzerland.
Kempf
W
W
Kazakov
D V
DV
Dummer
R
R
Burg
G
G
D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000473:pathology; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology; D012751:Sezary Syndrome / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D017730:Ki-1 Antigen