title: [Effect of hyperventilation on the cerebral blood flow and metabolism in patients with craniocerebral trauma].
abstract: Cerebral blood flow and metabolism were studied in 44 patients with acute severe craniocerebral injuries (contusions of the brain and removal of intracranial hematomas) with consciousness depression (moderate coma), hospitalized in intensive neurological care wards. Oxygen supply to the brain was repeatedly evaluated (acid-base status of the jugular vein blood, oxygen arterio-venous difference, oxygen extraction coefficient), oxymetry of the brain was repeatedly carried out, and vital functions were monitored over the entire period of disease. Cerebral blood flow was monitored by rheoencephalography, which helped timely detect the changes in cerebral blood flow in patients with craniocerebral injuries during different ventilation protocols used in intensive care. All studies were carried out during three stages: 1) initial stage, when the patients were brought to intensive neurological care wards after surgical intervention, and during normoventilation (paCO2 36-40 mm Hg; 2) moderate hyperventilation (paCO2 35-26 mm Hg); and 3) pronounced hyperventilation (paCO2 25-20 mm Hg). Specific changes in the cerebral blood flow during the acute period of craniocerebral injury were detected during different ventilation regimens in 2 groups of patients: group 1 with lethal outcomes and group 2 with positive changes.
authors.forename: I G
authors.initials: IG
authors.lastname: Bobrinskaia
authors.forename: E M
authors.initials: EM
authors.lastname: Levité
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Iminova
authors.forename: A P
authors.initials: AP
authors.lastname: Zemskov
authors.forename: D V
authors.initials: DV
authors.lastname: Nikolaev
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D006259:Craniocerebral Trauma / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006985:Hyperventilation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism
chemical_list: D010100:Oxygen