title: Norepinephrine transporter and alpha(2c) adrenoceptor allelic variants and personality factors.
abstract: It has been suggested that reward dependence, as measured by the Tridimensional Personality Questionnaire (TPQ), is related to central noradrenergic activity, a proposition supported by two studies of urinary norepinephrine metabolite. In the current investigation, 190 normal young Han Chinese were examined, with genetic polymorphisms determined for the norepinephrine transporter (1287G/A) and the alpha(2c)-adrenoceptor (Del322-325) to test the association with TPQ personality traits. No significant association was demonstrated for these two polymorphisms and any of the TPQ personality-factor scores, including reward dependence and its subscales. Our negative findings suggest that the investigated polymorphisms of the norepinephrine transporter and the alpha(2c) adrenoceptor do not play a major role in the reward-dependence personality trait as assessed by TPQ.
authors.affiliation: Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, Republic of China. sjtsai@vghtpe.gov.tw
authors.forename: Shih-Jen
authors.initials: SJ
authors.lastname: Tsai
authors.forename: Ying-Chieh
authors.initials: YC
authors.lastname: Wang
authors.forename: Chen-Jee
authors.initials: CJ
authors.lastname: Hong
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D050484:Norepinephrine Plasma Membrane Transport Proteins; D010551:Personality; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D011795:Surveys and Questionnaires; D027981:Symporters / Q000235:genetics*
chemical_list: C547774:ADRA2C protein, human; D050484:Norepinephrine Plasma Membrane Transport Proteins; D018341:Receptors, Adrenergic, alpha-2; C493227:SLC6A2 protein, human; D027981:Symporters; D009638:Norepinephrine