Is the bioreactivity of vitamin-E-modified dialyzer an expression of increased plasmatic vitamin E concentration?
The present study was designed to test the biocompatibility of a new vitamin E-modified multilayer membrane compared with highly biocompatible polysulphone dialyzer and acrylonitrile dialyzer. Thirty patients (mean age 53.2 +/- 15.3 SD years; dialytic age 36 +/- 5.6 months) were selected for the study. The study was divided into three periods of 6 months (phases A, B and C). In the first phase (from Jan. 1999 to June 1999) patients undergoing maintenance bicarbonate dialysis were randomly divided into three filter groups composed, respectively, of 10 patients: acrylonitrile group, polysulphone group and vitamin E-coated dialyzer group. In the phase B (from July 1999 to Dec. 1999) and in the phase C (from Jan. 2000 to June 2000), all three groups changed their own dialysis membranes. Vitamin E-coated dialyzer causes significant decreases in beta(2)-microglobulin, ferritin and immunoglobulin G, a normalization of complement C3 and an increase of plasmatic vitamin E compared to other filters. In the VE group homocysteine decreases but not in a significant manner. In addition, this dialyzer seems not to influence lipid pattern and protein-energy malnutrition parameters. These results clearly show a positive effect of this new filter in influencing different biochemical parameters, perhaps saving vitamin E and reducing polymorphonuclear cell activation.
Senatore
Massimimo
M
Nephrology and Dialysis Operative Unit, S. Giovanni in Fiore Hospital, Crotone, Italy.
Nicoletti
A
A
Rizzuto
G
G
D000181:Acrylonitrile; D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D018592:Cross-Over Studies; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage; D006801:Humans; D007688:Kidneys, Artificial; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis; D013450:Sulfones; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood*
D001672:Biocompatible Materials; D016166:Free Radical Scavengers; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D014810:Vitamin E; C017662:polysulfone P 1700; D000181:Acrylonitrile