title: In vitro activities of newer quinolones against bacteroides group organisms.
abstract: The activities of BMS-284576, clinafloxacin, moxifloxacin, sitafloxacin, trovafloxacin, imipenem, cefoxitin, and clindamycin against 589 Bacteroides fragilis group isolates were determined. The activity of BMS-284576 was comparable to that of trovafloxacin. Sitafloxacin and clinafloxacin were the most active quinolones, and moxifloxacin was the least active. B. fragilis was the most susceptible of the species, and Bacteroides vulgatus was the most resistant. Association of specific antibiotic resistance with Bacteroides species was noted for all quinolones.
authors.affiliation: Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. dsnydman@lifespan.org
authors.forename: D R
authors.initials: DR
authors.lastname: Snydman
authors.forename: N V
authors.initials: NV
authors.lastname: Jacobus
authors.forename: L A
authors.initials: LA
authors.lastname: McDermott
authors.forename: R
authors.initials: R
authors.lastname: Ruthazer
authors.forename: E
authors.initials: E
authors.lastname: Goldstein
authors.forename: S
authors.initials: S
authors.lastname: Finegold
authors.forename: L
authors.initials: L
authors.lastname: Harrell
authors.forename: D W
authors.initials: DW
authors.lastname: Hecht
authors.forename: S
authors.initials: S
authors.lastname: Jenkins
authors.forename: C
authors.initials: C
authors.lastname: Pierson
authors.forename: R
authors.initials: R
authors.lastname: Venezia
authors.forename: J
authors.initials: J
authors.lastname: Rihs
authors.forename: S L
authors.initials: SL
authors.lastname: Gorbach
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D001439:Bacteroides / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones; D006801:Humans; D007211:Indoles; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology; D011804:Quinolines; D015363:Quinolones
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D007211:Indoles; D009287:Naphthyridines; D011804:Quinolines; D015363:Quinolones; C057477:clinafloxacin; C080163:trovafloxacin; C076246:sitafloxacin; D000077266:Moxifloxacin; C419689:garenoxacin