Norepinephrine transporter and alpha(2c) adrenoceptor allelic variants and personality factors.
It has been suggested that reward dependence, as measured by the Tridimensional Personality Questionnaire (TPQ), is related to central noradrenergic activity, a proposition supported by two studies of urinary norepinephrine metabolite. In the current investigation, 190 normal young Han Chinese were examined, with genetic polymorphisms determined for the norepinephrine transporter (1287G/A) and the alpha(2c)-adrenoceptor (Del322-325) to test the association with TPQ personality traits. No significant association was demonstrated for these two polymorphisms and any of the TPQ personality-factor scores, including reward dependence and its subscales. Our negative findings suggest that the investigated polymorphisms of the norepinephrine transporter and the alpha(2c) adrenoceptor do not play a major role in the reward-dependence personality trait as assessed by TPQ.
Tsai
Shih-Jen
SJ
Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, Republic of China. sjtsai@vghtpe.gov.tw
Wang
Ying-Chieh
YC
Hong
Chen-Jee
CJ
D000328:Adult; D000483:Alleles; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D050484:Norepinephrine Plasma Membrane Transport Proteins; D010551:Personality; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D011795:Surveys and Questionnaires; D027981:Symporters / Q000235:genetics*
C547774:ADRA2C protein, human; D050484:Norepinephrine Plasma Membrane Transport Proteins; D018341:Receptors, Adrenergic, alpha-2; C493227:SLC6A2 protein, human; D027981:Symporters; D009638:Norepinephrine