title: Effect of chitosan oligosaccharide on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in mice.
abstract: The abilities of two types of chitosan oligosaccharides, chitosan oligosaccharide I (1-kDa<MW<3-kDa) and chitosan oligosaccharide II (3-kDa<MW<5-kDa), to prevent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress were examined in ICR mice. Chitosan oligosaccharide I had no effect on TCDD-induced alterations in lipid peroxidation and glutathione S-transferase activity or liver weight change. However, mice treated with chitosan oligosaccharide II were protected from TCDD-induced lipid peroxidation, inhibition of glutathione peroxidase and glutathione S-transferase activities, and losses in body and liver weights. These results suggest that chitosan oligosaccharide might be a potential agent for combating TCDD-induced pathogenesis.
authors.affiliation: Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University, Kyongju, Korea.
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Shon
authors.forename: In-Kook
authors.initials: IK
authors.lastname: Park
authors.forename: Il-Soo
authors.initials: IS
authors.lastname: Moon
authors.forename: Hyeun Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: In-Kyung
authors.initials: IK
authors.lastname: Park
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Nam
mesh_terms: D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D048271:Chitosan; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D009844:Oligosaccharides / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*
chemical_list: D009844:Oligosaccharides; D000072317:Polychlorinated Dibenzodioxins; D002686:Chitin; D048271:Chitosan