Use of Vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles.
The solid-phase synthesis of novel imidazolines and dihydroimidazolylbenzimidazoles is described. Resin-bound diamines, derived from resin-bound N-acylated amino acid amides, were cyclized using Vilsmeier reagent to yield imidazolines following cleavage. Similarly, cyclization of resin-bound tetraamines having two secondary amines and an o-dianiline yielded dihydroimidazolylbenzimidazoles following cleavage.
Acharya
Achyuta N
AN
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA.
Thai
Cattram
C
Ostresh
John M
JM
Houghten
Richard A
RA
D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*
D007093:Imidazoles; D007202:Indicators and Reagents