Stereoselective preparation of highly functionalized (Z)-3-magnesiated enoates by an iodine-magnesium exchange reaction.
3-Iodoenoates are converted into the corresponding alkenylmagnesium species with complete retention of configuration of the double bond; both direct reaction and copper(I)-mediated reactions with various electrophiles provide polyfunctional enoates.
Sapountzis
I
I
Department Chemie, Ludwig-Maximilians-Universität München, Butenandstr. 5-13, Haus F, D-81377 München, Germany.
Dohle
W
W
Knochel
P
P