title: Massive OxyContin ingestion refractory to naloxone therapy.
abstract: OxyContin (oxycodone hydrochloride controlled release) is a long-acting preparation of oxycodone that is used as an opioid analgesic to treat chronic pain conditions. We report a patient who ingested a massive quantity of OxyContin and had altered mental status, noncardiogenic pulmonary edema, and hypoventilation that proved refractory to naloxone administration. She required mechanical ventilation for 3 days before recovering completely. The severity and length of poisoning was likely related both to the quantity and formulation of the oxycodone ingested.
authors.affiliation: Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego Medical Center, 92103-8925, USA. aschneir@ucsd.edu
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Schneir
authors.forename: Tyler F
authors.initials: TF
authors.lastname: Vadeboncoeur
authors.forename: Steven R
authors.initials: SR
authors.lastname: Offerman
authors.forename: James D
authors.initials: JD
authors.lastname: Barry
authors.forename: Binh T
authors.initials: BT
authors.lastname: Ly
authors.forename: Saralyn R
authors.initials: SR
authors.lastname: Williams
authors.forename: Richard F
authors.initials: RF
authors.lastname: Clark
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D009294:Narcotics / Q000506:poisoning*; D010098:Oxycodone / Q000037:antagonists & inhibitors / Q000506:poisoning*; D012121:Respiration, Artificial; D012720:Severity of Illness Index; D013406:Suicide, Attempted; D016896:Treatment Outcome
chemical_list: D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D010098:Oxycodone