title: Drosophila germline invasion by the endogenous retrovirus gypsy: involvement of the viral env gene.
abstract: The endogenous retrovirus gypsy is expressed at high levels in mutant flamenco female flies. Gypsy viral particles extracted from such flies can infect naive flamenco individuals raised in the presence of these extracts mixed into their food. This results in the integration of new proviruses into the germline genome. These proviruses can then increase their copy number by (1) expression in the flamenco female somatic cells, (2) transfer into the oocyte and (3) integration into the genome of the progeny. Surprisingly, unlike the infection observed in the feeding experiments, this strategy of endogenous proviral multiplication does not seem to involve the expression of the viral env gene.
authors.affiliation: I.G.H. du CNRS (UPR 1142), 141 rue de la Cardonille, Montpellier, France. alain.pelisson@igh.cnrs.fr
authors.forename: A
authors.initials: A
authors.lastname: Pelisson
authors.forename: L
authors.initials: L
authors.lastname: Mejlumian
authors.forename: V
authors.initials: V
authors.lastname: Robert
authors.forename: C
authors.initials: C
authors.lastname: Terzian
authors.forename: A
authors.initials: A
authors.lastname: Bucheton
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004331:Drosophila melanogaster / Q000235:genetics*; D020077:Endogenous Retroviruses / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D015752:Genes, env; D005854:Germ Cells; D006801:Humans; D011533:Proviruses / Q000235:genetics / Q000502:physiology; D014779:Virus Replication