title: Advances in polycystic ovary syndrome treatment: metformin and ovarian diathermy.
abstract: Polycystic ovary syndrome (PCOS) affects approximately 6% of women in their reproductive years. The symptoms of the syndrome are chronic anovulation and androgen excess. Infertility due to ovulatory dysfunction is a common problem for women with PCOS. Metformin, an antihyperglycemic agent, can correct the metabolic dysfunction that occurs with PCOS, and also stimulate folliculogenesis. The drug is effective alone and in combination with clomiphene citrate. An alternative option, ovarian diathermy, also promotes ovulation through changes in the intraovarian hormonal environment. Both techniques provide promising and effective alternatives for women with PCOS who do not respond to traditional oral ovulation induction agents.
authors.affiliation: Department of Obstetrics & Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. leclairc@ohsu.edu
authors.forename: Catherine
authors.initials: C
authors.lastname: Leclair
authors.forename: Phillip E
authors.initials: PE
authors.lastname: Patton
mesh_terms: D000465:Algorithms; D000858:Anovulation / Q000209:etiology / Q000628:therapy; D002996:Clomiphene / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003972:Diathermy; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use*; D006080:Ovarian Follicle / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy*
chemical_list: D007004:Hypoglycemic Agents; D002996:Clomiphene; D008687:Metformin