title: The influence of the acetabular labrum seal, intact articular superficial zone and synovial fluid thixotropy on squeeze-film lubrication of a spherical synovial joint.
abstract: A model of synovial fluid (SF) filtration by articular cartilage (AC) in a step-loaded spherical synovial joint at rest is presented. The effects of joint pathology (such as a depleted acetabular labrum, a depleted cartilage superficial zone consistent with early osteoarthritis and an inflammatory SF) on the squeezed synovial film are also investigated. Biphasic mixture models for AC (ideal fluid and elastic porous transversely isotropic two-layer matrix) and for SF (ideal and thixotropic fluids) are applied and the following results are obtained. If the acetabular labrum is able to seal the pressurised SF between the articular surfaces (as in the normal hip joint), the fluid in the synovial film and in the cartilage within the labral ring is homogeneously pressurised. The articular surfaces remain separated by a fluid film for minutes. If the labrum is destroyed or absent and the SF can escape across the contact edge, the fluid pressure is non-homogeneous and with a small jump at the articular surface at the very moment of load application. The ensuing synovial film filtration by porous cartilage is lower for the normal cartilage (with the intact superficial zone) than if this zone is already depleted or rubbed off as in the early stage of primary osteoarthritis. Compared with the inflammatory (Newtonian) SF, the normal (thixotropic) fluid applies favourably in the squeezed film near the contact centre only, yielding a thicker SF film there, but not affecting the minimum thickness in the fluid film profile at a fixed time. For all that, in the unsealed case for both the normal and pathological joint, the macromolecular concentration of the hyaluronic acid-protein complex in the synovial film quickly increases due to the filtration in the greater part of the contact. A stable synovial gel film, thick on the order of 10(-7)m, protecting the articular surfaces from the intimate contact, is formed within a couple of seconds. Boundary lubrication by the synovial gel is established if sliding motion follows until a fresh SF is entrained into the contact. This theoretical prediction is open for experimental verifications.
authors.affiliation: Institute of Theoretical and Applied Mechanics, Academy of Sciences of the Czech Republic, Prosecká 76, Prague, Czech Republic. hlavacek@itam.cas.cz
authors.forename: M
authors.initials: M
authors.lastname: Hlavácek
mesh_terms: D000077:Acetabulum / Q000502:physiology; D002358:Cartilage, Articular / Q000502:physiology*; D003198:Computer Simulation; D005374:Filtration; D006621:Hip Joint / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011312:Pressure; D012212:Rheology / Q000379:methods*; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013582:Synovial Fluid / Q000502:physiology*; D013583:Synovial Membrane / Q000502:physiology; D014783:Viscosity; D016474:Weight-Bearing / Q000502:physiology