Solid phases of tenoxicam.
In this report we describe the preparation and characterization of four polymorphic forms of tenoxicam; they are, three 1:1 stoichiometric solvates with acetonitrile, dioxane, and N,N-dimethylformamide, and an amorphous phase obtained by recrystallization in various solvents. Polymorph IV and solvates with dioxane and N,N-dimethylformamide are reported for the first time in this paper. In addition, three solvates were crystallized in acetone, ethyl acetate, and isopropyl alcohol. These solid forms were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy, thermogravimetry, optical microscopy, and elemental analysis. Solid-state properties, intrinsic dissolution rate, and dissolution kinetics from formulated tablets are also provided.
Cantera
Rodrigo G
RG
The Galenic Center, University of Navarra, Irunlarrea s/n, E-31080 Pamplona, Spain. r.cantera@inabonos.com
Leza
María G
MG
Bachiller
Carmen M
CM
D020001:1-Butanol; D019840:2-Propanol / Q000737:chemistry; D000081:Acetamides; D000085:Acetates / Q000737:chemistry; D000096:Acetone / Q000737:chemistry; D000097:Acetonitriles / Q000737:chemistry; D001554:Benzene; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002725:Chloroform; D018360:Crystallography, X-Ray; D004126:Dimethylformamide / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000737:chemistry*; D012995:Solubility; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000081:Acetamides; D000085:Acetates; D000097:Acetonitriles; D004146:Dioxanes; D012997:Solvents; D000096:Acetone; D010894:Piroxicam; C007650:ethyl acetate; D002725:Chloroform; D004126:Dimethylformamide; D020001:1-Butanol; D001554:Benzene; C013959:dimethylacetamide; D019840:2-Propanol; C032159:acetonitrile; C032801:tenoxicam