title: Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of scavenger receptor BI without affecting bile acid biosynthesis in hamsters.
abstract: The purpose of this study was to analyze the effects of increasing amounts of dietary myristic acid (0.03 to 4.2% of the total dietary energy) on the plasma and hepatic cholesterol metabolism. Six groups of hamsters received semi-purified diets containing 0.05% cholesterol and 12.5% lipids and differing only by the nature of the triglycerides (Safflower oil, lard, lard/coconut oil (1:1), milk fat, milk fat/coconut oil (1:1), coconut oil) for 3 weeks. A positive regression between the plasma cholesterol level and the dietary myristic acid level was observed (r = 0.60, P < 0.0001). However, it is noteworthy that the increase in plasma total cholesterol only reflects an increase in the level of HDL-cholesterol. In parallel, the mass SR-BI decreased linearly with the increased level of myristic acid in the diet, whereas the LDL-R did not change. This study shows that increasing amounts of myristic acid (0.03 to 4.2%) do not alter the cholesterol or bile acid metabolism and increase only the HDL-C.
authors.affiliation: Laboratoire de Physiologie de la Nutrition, Université Paris-Sud, Centre d'Orsay, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Loison
authors.forename: François
authors.initials: F
authors.lastname: Mendy
authors.forename: Colette
authors.initials: C
authors.lastname: Serougne
authors.forename: Claude
authors.initials: C
authors.lastname: Lutton
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D018955:CD36 Antigens / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D006224:Cricetinae; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins; D008647:Mesocricetus; D019814:Myristic Acid / Q000008:administration & dosage* / Q000378:metabolism; D011897:Random Allocation; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
chemical_list: D001647:Bile Acids and Salts; D018955:CD36 Antigens; D008076:Cholesterol, HDL; D004041:Dietary Fats; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D019814:Myristic Acid; D002784:Cholesterol