title: Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
abstract: Fifty-eight curcumin analogues were prepared and evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Compound was the most potent analogue against several cell lines, including HOS (bone cancer) and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 microg/mL, respectively.
authors.affiliation: Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Ishida
authors.forename: Hironori
authors.initials: H
authors.lastname: Ohtsu
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tachibana
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagai
authors.forename: Hui-Kang
authors.initials: HK
authors.lastname: Wang
authors.forename: Hideji
authors.initials: H
authors.lastname: Itokawa
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006865:Hydrogenation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D003474:Curcumin