title: Disruption of protein-protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase.
abstract: Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1:1 Cc:1 complex with a binding constant of (3 +/- 1) x 10(8) M-1, and to disrupt Cc: Apaf-1 complex, a key adduct in apoptosis.
authors.affiliation: Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA. weiyen@drexel.edu
authors.forename: Y
authors.initials: Y
authors.lastname: Wei
authors.forename: G L
authors.initials: GL
authors.lastname: McLendon
authors.forename: A D
authors.initials: AD
authors.lastname: Hamilton
authors.forename: M A
authors.initials: MA
authors.lastname: Case
authors.forename: C B
authors.initials: CB
authors.lastname: Purring
authors.forename: Q
authors.initials: Q
authors.lastname: Lin
authors.forename: H S
authors.initials: HS
authors.lastname: Park
authors.forename: C S
authors.initials: CS
authors.lastname: Lee
authors.forename: T
authors.initials: T
authors.lastname: Yu
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D053477:Apoptotic Protease-Activating Factor 1; D001667:Binding, Competitive / Q000187:drug effects; D002352:Carrier Proteins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D003574:Cytochrome c Group / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003578:Cytochrome-c Peroxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics
chemical_list: D053477:Apoptotic Protease-Activating Factor 1; D002352:Carrier Proteins; D003574:Cytochrome c Group; D011506:Proteins; D003578:Cytochrome-c Peroxidase