title: [Biochemical characteristics of hepatic functions in different clinical forms of chronic opisthorchiasis].
abstract: The main biochemical indices of hepatic functions (the activities of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, alpha-amylase, choline esterase and the concentrations of total bilirubin, cholesterol, and glucose) were studied in the sera of 256 patients with chronic opisthorchiasis. It was found that with diseases manifested in different clinical forms (cholangitis, cholecystitis, cholangiocholecystitis, cholangiohepatitis, cholecystitis in combination with pancreatitis), most study indices are within the normal ranges, but significantly differ from the means in a group of apparently healthy individuals. The findings suggest that such clinical forms of opisthorchiais as cholangiocholecystitis and cholangiohepatitis are characterized by manifestations of cytolysis and cholestasis, as cholecystitis is manifested by cytolysis, as cholecystitis in combination with pancreatitis, by cholestasis, and as cholangitis, by cholestasis and hepatic cell insufficiency. It is possible that further studies will provide evidence for how to correct detected disorders during pathogenetic therapy.
authors.forename: I V
authors.initials: IV
authors.lastname: Bakshtanovskaia
authors.forename: T F
authors.initials: TF
authors.lastname: Stepanova
authors.forename: A L
authors.initials: AL
authors.lastname: Shonin
authors.forename: V K
authors.initials: VK
authors.lastname: Terekhina
authors.forename: O V
authors.initials: OV
authors.lastname: Ponomareva
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002761:Cholangitis / Q000097:blood / Q000469:parasitology; D002764:Cholecystitis / Q000097:blood / Q000469:parasitology; D002784:Cholesterol / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D002908:Chronic Disease; D004066:Digestive System Diseases / Q000097:blood / Q000378:metabolism* / Q000469:parasitology; D006521:Hepatitis, Chronic / Q000097:blood / Q000469:parasitology; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008875:Middle Aged; D009889:Opisthorchiasis / Q000097:blood / Q000378:metabolism*; D010195:Pancreatitis / Q000097:blood / Q000469:parasitology; D000516:alpha-Amylases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D000516:alpha-Amylases; D001663:Bilirubin