Interleukin-10 promoter polymorphisms in patients with multiple sclerosis.
The expression level of interleukin-10 (IL-10) is related to polymorphisms -1082 (G/A), -819 (T/C) and -592 (A/C) in the promoter region of the IL-10 gene. The distribution of these polymorphisms was analyzed to determine whether they could influence disease susceptibility or clinical course in multiple sclerosis (MS). The -1082 (G/A), -819 (T/C) and -592 (A/C) genotypes were similarly distributed between MS patients and the controls. The primary progressive MS patients with the low IL-10 expression haplotype showed a trend towards a worse clinical outcome than did patients with medium- or high-expression haplotypes (P = 0.056). The polymorphisms did not influence the clinical course in patients with relapsing-remitting MS.
Myhr
Kjell-Morten
KM
The Multiple Sclerosis National Competence Centre, Department of Neurology, Haukeland Hospital, University of Bergen, N-5021 Bergen, Norway. kjmy@haukland.no
Vågnes
Kari S
KS
Marøy
Tove H
TH
Aarseth
Jan H
JH
Nyland
Harald I
HI
Vedeler
Christian A
CA
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D020528:Multiple Sclerosis, Chronic Progressive / Q000235:genetics* / Q000276:immunology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D016753:Interleukin-10