[Changes in the activity of elastase and its inhibitors in the aorta tissue and blood serum of rats with streptozocin-induced diabetes].
On the model of streptozocin-induced diabetes mellitus in rats an imbalance between elastase and its inhibitors--alpha 1-inhibitor of proteinase and alpha 2-macroglobulin in blood serum and aortic tissues has been established. The results obtained evidenced for significant imbalance of proteoclastic system towards enhancing the activity of proteinase and decreasing the content of its inhibitors. A decrease in anti-elastase activity of inhibitors in blood serum and aorta was due to alpha 2-macroglobulin as the most important anti-elastase protein in aortic tissue. Disturbances in the proteolytic system increased progressively at prolonging the experiment. An imbalance between elastase and its inhibitors at early stages of diabetes may be considered as an important pathogenic mechanism of such macroangiopathies as atherosclerosis and Menkeber's arteriosclerosis.
Borysiuk
M V
MV
A.A. Bogomoletz Medical University, Kiev.
D000818:Animals; D001011:Aorta / Q000201:enzymology*; D001161:Arteriosclerosis / Q000209:etiology; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000150:complications; D008297:Male; D010196:Pancreatic Elastase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010196:Pancreatic Elastase