GH-IGF-I axis in non-obese women with functional hyperandrogenism.
The study was conducted to assess the GH-IGF-I axis in non-obese women with functional hyperandrogenism (FH). Eighteen FH women aged 18-35 yr with a body weight within 20% of ideal body weight and 10 weight-matched controls were included in the study. Basal serum GH, GH-binding protein (GHBP), IGF-I, IGF-binding protein-3 (IGFBP-3) levels were determined as well as GH levels during GHRH stimulation. In addition, basal serum androgens [free T (FT), delta4 and DHEAS], insulin and glucose levels were determined. The group of non-obese patients with FH differed from controls in GHBP (1.21+/-0.37 vs 0.93+/-0.25 nmol/l; p<0.05) and androgen levels (FT: 8.0+/-3.2 vs 1.9+/-1.2 pmol/l, p<0.001; delta4: 10.5+/-3.2 vs 5.9+/-2.1 nmol/l, p<0.001; DHEAS: 9.3+/-3.0 vs 5.1+/-1.8 micromol/l, p<0.001). GH (r=0.365; p<0.05) and IGF-I (r=0.508, p<0.01) serum levels were significantly correlated to serum DHEAS levels in a combined group of patients and controls. Our results support the suggestion that the GH-IGF-I axis plays an important role in the evolution of hormonal and metabolic derangement in non-obese FH women.
Legan
M
M
Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Slovenia. mateja.legan@mf.uni-lj.si
Kocijancic
A
A
Prezelj
J
J
Osredkar
J
J
Fisker
S
S
D000328:Adult; D001835:Body Weight; D002352:Carrier Proteins / Q000097:blood; D035061:Control Groups; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000473:pathology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*
D002352:Carrier Proteins; D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D019314:Dehydroepiandrosterone Sulfate; D007334:Insulin-Like Growth Factor I; D013007:Growth Hormone-Releasing Hormone; C051815:somatotropin-binding protein