title: MHC/peptide tetramer-based studies of T cell function.
abstract: Direct visualization and quantification of antigen-specific T cells using major histocompatibility complex (MHC)/peptide tetramer technology offers a powerful means to study specific T cell populations of interest. In combination with functional assays, this technology has already provided many new insights into several long-standing immunological concepts in basic science as well as clinical settings.
authors.affiliation: MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK. xiaoning@molbiol.ox.ac.uk
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Xu
authors.forename: Gavin R
authors.initials: GR
authors.lastname: Screaton
mesh_terms: D017209:Apoptosis; D015551:Autoimmunity; D006084:Graft Rejection; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007167:Immunotherapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D020836:Protein Structure, Quaternary; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I