Molecular prognostic indicators in breast cancer.
Here we review a panel of oncogene products, proteases and markers of proliferation that have shown potential as prognostic indicators in primary breast cancer. The relative merits of specific genetic mutations as well as alterations at the protein level are discussed. Finally an assessment is made of the transfer of knowledge from the laboratory to the bed-side.
Rogers
C E
CE
University of Hull Academic Surgical Unit, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 5JQ, UK.
Loveday
R L
RL
Drew
P J
PJ
Greenman
J
J
D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007202:Indicators and Reagents; D009154:Mutation / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D011379:Prognosis; D016387:Women's Health
D014408:Biomarkers, Tumor; D007202:Indicators and Reagents; D009363:Neoplasm Proteins