Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes.
The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.
den Heijer
T
T
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands.
Oudkerk
M
M
Launer
L J
LJ
van Duijn
C M
CM
Hofman
A
A
Breteler
M M B
MM
D000368:Aged; D000679:Amygdala / Q000473:pathology*; D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001284:Atrophy; D001927:Brain Diseases / Q000235:genetics* / Q000473:pathology*; D003071:Cognition; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E