[Effects of complexes of alpha-fetoprotein and amphiphilic docosaenoic acid derivatives on the humoral immune response in C57BL/6 mice].
The immunotropic activity of three derivatives of docosahexaenic acid (N-docosahexaenoyl-L-serine phosphate, N-docosahexaenoyl-L-threonine phosphate, and N-docosahexaenoyl-L-tyrosine phosphate) in complexes with high-purity human alpha-fetoprotein was evaluated. The polyene compounds stimulate the humoral immunity in mice immunized with T-dependent antigen (ram red blood cells). The immunotropic activity of the alpha-fetoprotein-ligand complexes studied depends on the structure and the content of polyene ligands.
Arsenov
D V
DV
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul. Akademika Kuprevicha 5/2, Minsk, 220141 Belarus.
Golubeva
M B
MB
Kisel'
M A
MA
Konoplia
N A
NA
Kuz'mitskiĭ
B B
BB
Liubin
G S
GS
Strel'chenok
O A
OA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004281:Docosahexaenoic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D051379:Mice; D008810:Mice, Inbred C57BL; D012694:Serine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013912:Threonine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D000509:alpha-Fetoproteins / Q000737:chemistry / Q000494:pharmacology*
D008024:Ligands; C465402:N-docosahexaenoylserine phosphate; C465400:N-docosahexaenoylthreonine phosphate; C465401:N-docosahexaenoyltyrosine phosphate; D000509:alpha-Fetoproteins; D004281:Docosahexaenoic Acids; D013912:Threonine; D014443:Tyrosine; D012694:Serine