title: Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loss patients.
abstract: Normal pregnancy requires a series of immunological, metabolic, vascular and endocrine regulating processes. However, the specific genes and proteins involved in these processes are not well defined. Aberration of these processes may lead to problems in pregnancy. One of these problems may be recurrent pregnancy loss (RPL). Little information is available on the level of expression of genes that may play a role in normal pregnancy. Therefore, this study determined whether different levels of gene expression at the feto-maternal interface could be associated with factors for RPL. The expression patterns of genes isolated from subtractive hybridization analysis performed with chorionic villi from normal and abnormal pregnancies were investigated. Eight genes classified into groups, including immunosuppression-related, embryo attachment-related and angiogenesis-related, were isolated.
authors.affiliation: College of Medicine, Pochon CHA University, Infertility Medical Center, CHA General Hospital, Kangnam-Gu, Seoul, Korea. baek@cha.ac.kr
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Baek
authors.forename: Bum Chae
authors.initials: BC
authors.lastname: Choi
authors.forename: Jin-Hie
authors.initials: JH
authors.lastname: Lee
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Choi
authors.forename: Sook-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Jung-Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hill
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Chung
authors.forename: Jung Jae
authors.initials: JJ
authors.lastname: Ko
authors.forename: Kwang Yul
authors.initials: KY
authors.lastname: Cha
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D006063:Chorionic Gonadotropin / Q000235:genetics; D002824:Chorionic Villi / Q000737:chemistry; D010064:Embryo Implantation / Q000235:genetics; D005260:Female; D005353:Fibronectins / Q000235:genetics; D015870:Gene Expression; D005914:Globins / Q000235:genetics; D000071816:Glycodelin; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000235:genetics; D018396:Mucin-1 / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000235:genetics; D009693:Nucleic Acid Hybridization / Q000379:methods; D010446:Peptide Fragments / Q000235:genetics; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D006063:Chorionic Gonadotropin; D005353:Fibronectins; D000071816:Glycodelin; D006023:Glycoproteins; C116055:MUC1 tandem repeat peptide; D018396:Mucin-1; C045246:PAEP protein, human; D010446:Peptide Fragments; D011257:Pregnancy Proteins; D012333:RNA, Messenger; D005914:Globins; D020778:Matrix Metalloproteinase 2