A photochemical route for efficient cyclopeptide formation with a minimum of protection and activation chemistry.
An elaborated protocol is described which allows the efficient transformation of di-, tri-, and tetrapeptides into cyclopeptides with a minimum of protection and activation chemistry using the photoinduced electron transfer initiated decarboxylation of N-phthaloyl peptides resulting in C-C coupling between the initially formed carbon radicals.
Griesbeck
Axel G
AG
Institute of Organic Chemistry, University of Cologne, Greinstrasse 4, D-50939 Köln, Germany. griesbeck@unikoeln.de
Heinrich
Thomas
T
Oelgemöller
Michael
M
Lex
Johann
J
Molis
Arne
A
D003500:Cyclization; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D010777:Photochemistry
D009842:Oligopeptides; D010456:Peptides, Cyclic