title: Toll and interleukin-1 receptor (TIR) domain-containing proteins in plants: a genomic perspective.
abstract: Toll and interleukin-1 receptor (TIR) domains were originally described from comparisons of proteins found in mammals and Drosophila. They are now known to occur in several organisms, with the most TIR proteins being found in Arabidopsis: our analysis of the sequenced Arabidopsis genome has revealed the presence of at least 135 proteins containing TIR domains. Several novel types of TIR-domain-containing proteins are found in Arabidopsis that are not found in other genomes. Here, we discuss the roles of TIR-domain-containing proteins in pathogen resistance and as candidate signaling modules.
authors.affiliation: Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Jebanathirajah
authors.forename: Suraj
authors.initials: S
authors.lastname: Peri
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
mesh_terms: D000818:Animals; D017487:Ankyrins / Q000235:genetics; D017360:Arabidopsis / Q000235:genetics*; D029681:Arabidopsis Proteins / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D018745:Genome, Plant; D006801:Humans; D000090263:Leucine-Rich Repeat Proteins; D008562:Membrane Glycoproteins / Q000235:genetics*; D010935:Plant Diseases / Q000235:genetics; D010940:Plant Proteins / Q000235:genetics; D011506:Proteins / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics*; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D051193:Toll-Like Receptors
chemical_list: D017487:Ankyrins; D029681:Arabidopsis Proteins; D029721:Drosophila Proteins; D000090263:Leucine-Rich Repeat Proteins; D008562:Membrane Glycoproteins; C089425:N protein, Nicotiana glutinosa; D010940:Plant Proteins; D011506:Proteins; D011956:Receptors, Cell Surface; D017472:Receptors, Interleukin-1; D051193:Toll-Like Receptors