Aging and neural control of the GI tract. II. Neural control of the aging gut: can an old dog learn new tricks?
There has been a dramatic increase in funding available for aging research, primarily due to the fact that answers to questions on aging are likely to have a major impact on the well-being and healthy aging of the world's population for decades to come. The incidence of certain gastrointestinal problems, such as dysphagia and constipation, increases dramatically with age. Changes in gastrointestinal neuromuscular function with aging have been demonstrated in both human and animal models of aging. This article focuses on recent advances in our knowledge of the effects of aging on gastrointestinal function, treatment options, and future opportunities for research.
Hall
Karen E
KE
Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Healthcare System and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. kehall@umich.edu
D000375:Aging; D001003:Anal Canal / Q000503:physiopathology; D003106:Colon / Q000503:physiopathology; D003679:Deglutition; D004064:Digestive System / Q000294:innervation* / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D009416:Nerve Regeneration; D009424:Nervous System Physiological Phenomena; D009469:Neuromuscular Junction; D009474:Neurons / Q000502:physiology