[Postpartum hypercalcemia in a patient with previous thyroid carcinoma: a report of 2 cases].
We report postpartum hypercalcemia in 2 patients with previous thyroid carcinoma who had undergone total thyroidectomy and total parathyroidectomy and required vitamin D and calcium therapy to control hypoparathyroidism. Postpartum, they required less vitamin D and calcium for satisfactory control. While lactating, they maintained normal serum calcium without supplementary vitamin D or calcium. Transient remission of hypoparathyroidism symptoms has been observed during lactation. Some studies have shown that parathyroid-related protein (PTHrP) is produced by breast tissue, having an endocrine-like effect. We discuss the mechanism of postpartum hypercalcemia.
Yasumatsu
Ryuji
R
Department of Otorhinolaryngology, Fukuoka City Hospital, Fukuoka.
Nakashima
Torahiko
T
Kuratomi
Yuichiro
Y
Komiyama
Sohtaro
S
D000328:Adult; D001940:Breast / Q000378:metabolism; D002118:Calcium / Q000009:adverse effects; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007011:Hypoparathyroidism; D007774:Lactation / Q000502:physiology; D044162:Parathyroid Hormone-Related Protein; D016105:Parathyroidectomy; D036361:Peptide Hormones / Q000096:biosynthesis / Q000502:physiology; D049590:Postpartum Period; D011247:Pregnancy; D012075:Remission, Spontaneous; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy; D014807:Vitamin D / Q000009:adverse effects
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones; D014807:Vitamin D; D002118:Calcium