title: Fluoroquinolone-resistant Streptococcus pneumoniae strains occur frequently in elderly patients in Japan.
abstract: We identified and genetically characterized seven fluoroquinolone-resistant Streptococcus pneumoniae strains among 293 clinical strains isolated from 1999 to 2001 in Japan. The resistant strains were isolated only from adults, and 7 of 31 isolates (22.6%) were from patients more than 20 years old. Resistant strains were not found in 262 isolates from children under age 10.
authors.affiliation: Department of Microbiology, Sapporo Medical University School of Medicine, Chuo-ku, Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Yokota
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Osamu
authors.initials: O
authors.lastname: Kuwahara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Habadera
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Hironori
authors.initials: H
authors.lastname: Ohuchi
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Akizawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Himi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fujii
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D017422:Sequence Analysis, DNA; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase