title: Molecular changes track recurrence and progression of bronchial precancerous lesions.
abstract: Diagnosis of lung cancer is reached when the disease had grown to advanced stages in its natural history. Thus, novel molecular markers for early detection and risk assessment are needed. Here we performed a longitudinal study of 20 morphological lesions occurred in the bronchial tree of high-risk patients. The lesions were subjected to LIFE (laser-induced fluorescence endoscopy) bronchoscopy and molecular follow-up over a 4 year period. The presence and the persistence of specific genetic alterations were correlated with recurrence or progression of the disease on follow-up. Molecular lesions considered as highly predictive of invasion could be prospectively used as diagnostic markers of high risk for lung cancer in exposed patients.
authors.affiliation: Unit of Molecular Cytogenetics, Department of Experimental Oncology, Via G Venezian 1, 20133 Milano, Italy. sozzi@institutotumori.mi.it
authors.forename: Gabriella
authors.initials: G
authors.lastname: Sozzi
authors.forename: Maria
authors.initials: M
authors.lastname: Oggionni
authors.forename: Loredana
authors.initials: L
authors.lastname: Alasio
authors.forename: Davide
authors.initials: D
authors.lastname: Conte
authors.forename: Luca
authors.initials: L
authors.lastname: Tavecchio
authors.forename: Silvana
authors.initials: S
authors.lastname: Pilotti
authors.forename: Pasquale
authors.initials: P
authors.lastname: Spinelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Calarco
mesh_terms: D017766:Acid Anhydride Hydrolases; D000368:Aged; D001999:Bronchoscopy; D018450:Disease Progression; D005819:Genetic Markers; D006801:Humans; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis*; D009364:Neoplasm Recurrence, Local; D011230:Precancerous Conditions / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D018570:Risk Assessment; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D005819:Genetic Markers; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53; D000099170:Bis(5'-adenosyl)triphosphatase