title: Effect of delavirdine on plasma lipids and lipoproteins in patients receiving antiretroviral therapy.
abstract: Plasma lipid and lipoprotein levels were measured at baseline and after 8 weeks of highly active antiretroviral therapy among patients receiving delavirdine with or without a protease inhibitor (PI). In patients receiving nucleoside reverse transcriptase inhibitors (NRTI) plus delavirdine, there was a statistically significant increase in cholesterol and HDL levels, whereas those receiving NRTI plus a PI had no significant change in their HDL levels. When delavirdine was combined with a PI, there was a more dramatic increase in both cholesterol and HDL concentrations.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, The George Washington University Medical Center, Washington DC, USA.
authors.forename: Afsoon D
authors.initials: AD
authors.lastname: Roberts
authors.forename: Angelike P
authors.initials: AP
authors.lastname: Liappis
authors.forename: Chris
authors.initials: C
authors.lastname: Chinn
authors.forename: David M
authors.initials: DM
authors.lastname: Parenti
authors.forename: Richard A
authors.initials: RA
authors.lastname: Muesing
authors.forename: Suzanne Z
authors.initials: SZ
authors.lastname: Schuck
authors.forename: Judy
authors.initials: J
authors.lastname: Hsia
authors.forename: Gary L
authors.initials: GL
authors.lastname: Simon
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D020008:Delavirdine / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D015497:HIV-1; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D018894:Reverse Transcriptase Inhibitors; D002784:Cholesterol; D020008:Delavirdine