title: Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO2 by using sequential administration of 15O-labeled compounds.
abstract: The purpose of this study was to develop a reliable and practical strategy that generates quantitative CBF and OEF maps accurately from PET data sets obtained with 15O-tracers. Sequential sinogram data sets were acquired after the administration of 15O-tracers, and combined single-frame images were obtained. The delay time between sampled input function and the brain was estimated from the H2(15)O study with the whole brain and the arterial time-activity curves (TACs). The whole-brain TACs were obtained from the reconstructed images (image-base method) and the sinogram data (sinogram-base method). Six methods were also evaluated for the dead-time and decay correction procedures in the process of generating a single-frame image from the dynamic sinogram. The estimated delay values were similar with both the sinogram-based and image-based methods. A lumped correction factor to a previously added single-frame sinogram caused an underestimation of CBF, OEF and CMRO2 by 16% at maximum, as compared with the correction procedure for a short sinogram. This suggested the need for a dynamic acquisition of a sinogram with a short interval. The proposed strategy provided an accurate quantification of CBF and OEF by PET with 15O-tracers.
authors.affiliation: Department of Investigative Radiology, National Cardio-Vascular Center, Research Institute, Suita, Osaka, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Shidahara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watabe
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Hisashi
authors.initials: H
authors.lastname: Oka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Sago
authors.forename: Takuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Miyake
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ishida
authors.forename: Kohei
authors.initials: K
authors.lastname: Hayashida
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Iida
mesh_terms: D000328:Adult; D000465:Algorithms; D001811:Blood Volume Determination / Q000379:methods; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000502:physiology*; D002560:Cerebrovascular Circulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D010104:Oxygen Radioisotopes / Q000145:classification; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods
chemical_list: D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D010100:Oxygen