title: EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.
abstract: EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute i.v. EP1572 administration (1.0 microg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.
authors.affiliation: Department of Internal Medicine, University of Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Broglio
authors.forename: F
authors.initials: F
authors.lastname: Boutignon
authors.forename: A
authors.initials: A
authors.lastname: Benso
authors.forename: C
authors.initials: C
authors.lastname: Gottero
authors.forename: F
authors.initials: F
authors.lastname: Prodam
authors.forename: E
authors.initials: E
authors.lastname: Arvat
authors.forename: C
authors.initials: C
authors.lastname: Ghè
authors.forename: F
authors.initials: F
authors.lastname: Catapano
authors.forename: A
authors.initials: A
authors.lastname: Torsello
authors.forename: V
authors.initials: V
authors.lastname: Locatelli
authors.forename: G
authors.initials: G
authors.lastname: Muccioli
authors.forename: D
authors.initials: D
authors.lastname: Boeglin
authors.forename: V
authors.initials: V
authors.lastname: Guerlavais
authors.forename: J A
authors.initials: JA
authors.lastname: Fehrentz
authors.forename: J
authors.initials: J
authors.lastname: Martinez
authors.forename: E
authors.initials: E
authors.lastname: Ghigo
authors.forename: R
authors.initials: R
authors.lastname: Deghenghi
mesh_terms: D000328:Adult; D000818:Animals; D001667:Binding, Competitive; D004305:Dose-Response Relationship, Drug; D054439:Ghrelin; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007211:Indoles; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D036361:Peptide Hormones / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D014364:Tryptophan / Q000031:analogs & derivatives
chemical_list: D054439:Ghrelin; D007211:Indoles; D009842:Oligopeptides; D036361:Peptide Hormones; C086184:hexarelin; D019382:Human Growth Hormone; C582727:macimorelin; D014364:Tryptophan; D013006:Growth Hormone