Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue.
A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5-20 fold) and in a reduced dinucleotide coenzyme (2-3 fold), while retaining reactivity towards hydride transfer.
Hentall
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PL
Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
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D000143:Acids / Q000737:chemistry; D003067:Coenzymes / Q000737:chemistry; D004355:Drug Stability; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D015394:Molecular Structure; D009243:NAD / Q000031:analogs & derivatives* / Q000737:chemistry*
D000143:Acids; D003067:Coenzymes; D009243:NAD