No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer Disease.
Nitric oxide synthase (NOS) has been implicated in the pathogenesis of Alzheimer disease (AD). To examine the role of the neuronal NOS (nNOS) gene in AD, patients (n = 139) and control subjects (n = 101) were genotyped for the nNOS dinucleotide polymorphism. No association was demonstrated for AD and this particular nNOS polymorphism.
Liou
Ying-Jay
YJ
Section of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, Republic of China.
Hong
Chen-Jee
CJ
Liu
Hsiu-Chih
HC
Liu
Chia-Yih
CY
Liu
Tsung-Yun
TY
Chen
I-Chun
IC
Tsai
Shih-Jen
SJ
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D018900:Dinucleotide Repeats; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009474:Neurons / Q000201:enzymology / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052248:Nitric Oxide Synthase Type I; D011110:Polymorphism, Genetic
C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I