Synthesis and mannose receptor-mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge.
Effect of charge and shape of multivalent lysine-based cluster glycomimetics on their mannose receptor-mediated uptake by human dendritic cells has been evaluated: The capture is strongly affected by the shape of the ligands. The effect of charge is less pronounced although positive charges on the ligands seem to favor non-specific endocytosis capture.
Angyalosi
Gerhild
G
SEDAC-Therapeutics, Parc Eurasanté, Le Galenis, Bât B, 85 rue Nelson Mandela, 59120 Loos, France.
Grandjean
Cyrille
C
Lamirand
Mélanie
M
Auriault
Claude
C
Gras-Masse
Hélène
H
Melnyk
Oleg
O
D003713:Dendritic Cells / Q000187:drug effects*; D005434:Flow Cytometry; D019793:Fluorescein; D005947:Glucose / Q000494:pharmacology*; D037181:Lectins, C-Type; D008024:Ligands; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D018716:Molecular Mimicry; D011801:Quinic Acid / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000187:drug effects*; D012765:Shikimic Acid / Q000494:pharmacology
D037181:Lectins, C-Type; D008024:Ligands; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D011801:Quinic Acid; D012765:Shikimic Acid; D005947:Glucose; D019793:Fluorescein