title: Solid-phase synthesis of alkyl aryl ethers via the Ullmann condensation.
abstract: Alkyl aryl ether formation is a frequently employed reaction in organic synthesis. Ullmann condensation is an alternative method to the widely used Mitsunobu reaction and is very useful in situations where application of the Mitsunobu reaction is limited. By application of this reaction to solid-phase synthesis of a series of alkyl aryl ethers, reaction conditions (catalyst, solvent, temperature, time, etc.) for a sterically hindered class of alcohols were investigated and optimized. A range of aryl halides was used to explore the scope of the reaction in solid phase.
authors.affiliation: Bristol-Myers Squibb Company, Experimental Station, E500-4206, Route 141 & Henry Clay Road, Wilmington, DE 19880-0500, USA. xiao-yi.xiao@syrrx.com
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Xiao
authors.forename: Rongshi
authors.initials: R
authors.lastname: Li
authors.forename: David
authors.initials: D
authors.lastname: Hurst
authors.forename: Hui
authors.initials: H
authors.lastname: Zhuang
authors.forename: Shuhao
authors.initials: S
authors.lastname: Shi
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Czarnik
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Robichaud
authors.forename: Dean A
authors.initials: DA
authors.lastname: Wacker
authors.forename: David W
authors.initials: DW
authors.lastname: Robertson