title: Efficacy of linezolid against methicillin-resistant or vancomycin-insensitive Staphylococcus aureus in a model of hematogenous pulmonary infection.
abstract: We investigated the activities of linezolid, vancomycin, and teicoplanin in a murine model of hematogenous pulmonary infection with Staphylococcus aureus. Our results demonstrate that linezolid clearly reduced bacterial numbers in the methicillin-resistant S. aureus hematogenous infection model and significantly improved the survival rate of immunocompromised mice infected with vancomycin-insensitive S. aureus compared with vancomycin and teicoplanin. The pharmacokinetic profiles also reflected the effectiveness of linezolid.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Japan. kyana-ngs@umin.ac.jp
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Toyomitsu
authors.initials: T
authors.lastname: Sawai
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakata
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tomono
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Ikuo
authors.initials: I
authors.lastname: Murata
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000081:Acetamides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000069349:Linezolid; D008297:Male; D016106:Methicillin Resistance; D051379:Mice; D023303:Oxazolidinones / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D013211:Staphylococcus aureus / Q000187:drug effects*; D017334:Teicoplanin / Q000493:pharmacokinetics / Q000627:therapeutic use; D014640:Vancomycin / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D017334:Teicoplanin; D014640:Vancomycin; D000069349:Linezolid