title: Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza.
abstract: The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 microg/ml and 11.1 microg/ml. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 microg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity.
authors.affiliation: Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.
authors.forename: Jeong Suk
authors.initials: JS
authors.lastname: Ko
authors.forename: Shi Young
authors.initials: SY
authors.lastname: Ryu
authors.forename: Young Sup
authors.initials: YS
authors.lastname: Kim
authors.forename: Mi Yeon
authors.initials: MY
authors.lastname: Chung
authors.forename: Jong Seong
authors.initials: JS
authors.lastname: Kang
authors.forename: Mun-Chual
authors.initials: MC
authors.lastname: Rho
authors.forename: Hyun Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Young Kook
authors.initials: YK
authors.lastname: Kim
mesh_terms: D045784:Abietanes; D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000818:Animals; D051048:Diacylglycerol O-Acyltransferase; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D027544:Salvia / Q000737:chemistry*; D013624:Taiwan
chemical_list: D045784:Abietanes; D004791:Enzyme Inhibitors; D010616:Phenanthrenes; C021751:tanshinone; D000217:Acyltransferases; D051048:Diacylglycerol O-Acyltransferase