Histometric study of socket healing after tooth extraction in rats treated with diclofenac.
The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors and 21 rats received saline. The animals were sacrificed 7, 14 and 21 days after tooth extraction. Progressive new bone formation and a decrease in the volume fraction of blood clot and connective tissue from 1 to 3 weeks after tooth extraction was quantified using the histometric point-counting method. Diclofenac treatment caused a significant delay in new bone formation in association with an impairment of blood clot remission/organization.
Yugoshi
Luciana Ibara
LI
Department of Morphology, Stomatology and Physiology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Brazil.
Sala
Miguel Angel
MA
Brentegani
Luiz Guilherme
LG
Lamano Carvalho
Teresa Lúcia
TL
D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D010012:Osteogenesis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac