Healing of fresh tibial fractures with OP-1. A preliminary report.
Osteogenic proteins (OP) are elements of a class of natural growth factors called Bone Morphogenetic Proteins (BMP). A specific member of this class is OP-1, a human recombinant protein that has osteogenic properties. The osteoinductive and osteoconductive properties of OP-1, with its specific collagen matrix, promote the generation of new functionally active, biologically and biomechanically mature bone. We carried out a clinical study to verify the potential of this protein in fresh tibial closed fractures, using OP-1 associated with osteosynthesis by means of a monolateral external fixator.
Maniscalco
Pietro
P
Dipartimento di Scienze Radiologiche ed Ortopedico-Riabilitative Clinica Ortopedica e Traumatologica, Università degli Studi di Siena. maniscalco@unisi.it
Gambera
Dario
D
Bertone
Celeste
C
Rivera
Fabrizio
F
Crainz
Edoardo
E
Urgelli
Stefano
S
D000328:Adult; D000368:Aged; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016267:External Fixators; D005260:Female; D005592:Fracture Fixation; D005596:Fractures, Closed / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D013978:Tibial Fractures / Q000188:drug therapy* / Q000601:surgery; D016212:Transforming Growth Factor beta; D016896:Treatment Outcome
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011993:Recombinant Fusion Proteins; D016212:Transforming Growth Factor beta