[Clinical significance of P-glycoprotein and CD34 expression of acute leukemia].
The expression of P-glycoprotein(P-170) and CD34 was detected in the bone marrow mononuclear cells of 30 patients with acute leukemia by immunocytochemical technique using JSB-1 and Tük 3 monoclonal antibody. The results were that expression of P-170 and CD34 had no significant difference between acute nonlymphoblastic leukemia and acute lymphoblastic leukemia(P > 0.05). The clinical therapeutic effect was poor in P-170 or CD34 positive patients and had significant difference compared with those negative patients(P < 0.05). Judgments of therapeutic effect for acute leukemia can be improved by detecting the expression of P-170 and CD34 simultaneously.
Lin
X M
XM
Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Xie
Z X
ZX
Zhu
P A
PA
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis*; D002648:Child; D005260:Female; D019450:Genes, MDR; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018952:Antigens, CD34