Fluorouracil as a treatment for corneal papilloma in a Malayan tapir.
A 26-year-old, wild caught, male Malayan tapir at the Miami Metrozoo with bilateral corneal papillomas was serially immobilized and given subconjunctival injections of fluorouracil. Over the course of 17 weeks five bilateral injections of 25 mg fluorouracil were given. This treatment caused regression of the corneal lesions as evidenced by decreased lesion diameter, decreased corneal vascularity, increased corneal clarity, and improved visual function. No adverse drug effects were observed.
Karpinski
Lorraine G
LG
South Dade Animal Hospital, Miami, FL 33143, USA. 3hughes@worldnet.att.net
Miller
Christine L
CL
D000818:Animals; D000836:Animals, Zoo; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D003228:Conjunctiva; D003316:Corneal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D007267:Injections / Q000662:veterinary; D008297:Male; D010212:Papilloma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010527:Perissodactyla
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil