Multi-component coupling reactions: synthesis of a guanidine containing analog of the hexahydropyrrolo[3,2-c]quinoline alkaloid martinelline.
A multi-component coupling reaction is used to synthesize a highly functionalized guanidine containing pyrroloquinoline analog of martinelline that displays bradykinin B2 receptor antagonist activity.
Batey
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Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6. rbatey@chem.utoronto.ca
Powell
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DA
D000818:Animals; D065168:Bradykinin Receptor Antagonists; D019791:Guanidine / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D043782:Receptor, Bradykinin B2; D013329:Structure-Activity Relationship
D065168:Bradykinin Receptor Antagonists; D011758:Pyrroles; D011804:Quinolines; D043782:Receptor, Bradykinin B2; C410408:martinelline; D019791:Guanidine