title: Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.
abstract: (5-Azidonaphthalene-1-sulfonamidoethyl)-5-O-(alpha-arabinofuranosyl)-alpha-D-arabinofuranoside 1 was synthesized as a photoaffinity probe for the determination of arabinosyl transferase activity and for the identification of binding and functional sites in Mycobacterium tuberculosis.
authors.affiliation: Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35255, USA.
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Pathak
authors.forename: Vibha
authors.initials: V
authors.lastname: Pathak
authors.forename: Sudagar S
authors.initials: SS
authors.lastname: Gurcha
authors.forename: Gurdyal S
authors.initials: GS
authors.lastname: Besra
authors.forename: Robert C
authors.initials: RC
authors.lastname: Reynolds
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D004187:Disaccharides / Q000138:chemical synthesis*; D004977:Ethambutol / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology*; D010430:Pentosyltransferases / Q000378:metabolism*; D019920:Photoaffinity Labels / Q000138:chemical synthesis*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: C471467:(5-azidonaphthalene-1-sulfonamidoethyl)-5-O-(arabinofuranosyl)-arabinofuranoside; D000995:Antitubercular Agents; D004187:Disaccharides; D019920:Photoaffinity Labels; D004977:Ethambutol; D010430:Pentosyltransferases; C101967:arabinosyltransferase