title: Cyst-like cerebral lesions in tuberous sclerosis.
abstract: Known brain manifestations of tuberous sclerosis (TSC) are cortical sclerotic tubera, giant cell astrocytomas, subependymal calcified nodules in the lateral walls of the lateral ventricles, and white matter heterotopias. In addition, small cyst-like lesions in the white matter have been described. We report on three TSC patients with hitherto undescribed large cyst-like cerebral lesions in subcortical and white matter locations. We emphasize that cystoid brain degeneration is a rare but typical cerebral manifestation of TSC and suggest that, in patients with such lesions, TSC should be taken into consideration.
authors.affiliation: Institute of Human Genetics, University of Erlangen-Nuremberg, Germany. hdrott@humgenet.uni-erlangen.de
authors.forename: Hans-Dieter
authors.initials: HD
authors.lastname: Rott
authors.forename: Beate
authors.initials: B
authors.lastname: Lemcke
authors.forename: Martin
authors.initials: M
authors.lastname: Zenker
authors.forename: Walter
authors.initials: W
authors.lastname: Huk
authors.forename: Jürgen
authors.initials: J
authors.lastname: Horst
authors.forename: Karin
authors.initials: K
authors.lastname: Mayer
mesh_terms: D000328:Adult; D020863:Central Nervous System Cysts / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D013687:Telencephalon / Q000002:abnormalities* / Q000473:pathology; D014402:Tuberous Sclerosis / Q000235:genetics / Q000473:pathology*