The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis.
OBJECTIVE
To clarify the mechanism of decreased serum uric acid (SUA) concentrations during acute gouty arthritis.


METHODS
Data from patients with acute gouty arthritis during and after an attack were investigated retrospectively. Other investigations, including changes in urinary excretion and biochemical markers, were performed prospectively.


RESULTS
SUA was significantly lower in the acute phase (7.5 +/- 1.4 mg/dl) than in the intercritical phase (8.5 +/- 0.9 mg/dl) (p < 0.0001). During the acute gout phase, a normal SUA level was found in 20 of 41 patients (49%). C-reactive protein (CRP) during acute attacks was significantly correlated with plasma interleukin 6 (IL-6) and cortisol (r = 0.645, p < 0.005; r = 0.460, p < 0.05). Percentage change in SUA at onset of attack correlated with CRP and IL-6 (r = 0.762, p < 0.0001; r = 0.630, p < 0.005), as well as with increased urinary excretion of uric acid, estimated by percentage change in fractional excretion of uric acid (FEua) during attack (r = 0.447, p < 0.05). Further, change in FEua was correlated with plasma cortisol levels during the acute attack (r = 0.534, p < 0.05).


CONCLUSIONS
Decrease in SUA during acute gouty arthritis is associated with increased urinary excretion of uric acid; an inflammatory process may play a role in the mechanism.
Urano
Wako
W
The Institute of Rheumatology, Tokyo Women's Medical University, Japan. wako@ior.twmu.ac.jp
Yamanaka
Hisashi
H
Tsutani
Hiroshi
H
Nakajima
Hiroshi
H
Matsuda
Yuko
Y
Taniguchi
Atsuo
A
Hara
Masako
M
Kamatani
Naoyuki
N
D000208:Acute Disease; D000328:Adult; D000368:Aged; D015210:Arthritis, Gouty / Q000097:blood* / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D018836:Inflammation Mediators / Q000032:analysis*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011336:Probability; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
D018836:Inflammation Mediators; D015850:Interleukin-6; D014527:Uric Acid; D002097:C-Reactive Protein; D006854:Hydrocortisone