[Development of pre-hepatic portal hypertension of the rat].
OBJECTIVE
A long-term study of the prehepatic portal hypertension model by triple stenosing ligation of the portal vein in the rat.


METHODS
A cluster analysis of the animals in the different evolutive stages of portal hypertension (1 1/2, 6, 12 and 14 months) has been carried out. This analysis has made it possible to identify three homogeneous groups (A, B and C) in relationship to the liver weight.


RESULTS
The animals with liver atrophy (group C) show a decrease of body, splenic and testicular weights as well as a higher development of the portosystemic collateral circulation in relation to the A and B groups.


CONCLUSIONS
The percentage of animals belonging to the group C decrease progressively during the evolution of portal hypertension and those animals corresponding to the group A, in which is superior the liver weight, increase, while the B group does not change.
Aller Reyero
M A
MA
Facultad de Medicina, Universidad Complutense, Pza. Ramón y Cajal s/n, 28040 Madrid. maaller@med.ucm.es
Diéguez Fernández
B
B
Nava Hidalgo
M P
MP
Cuesta Alvaro
P
P
Sánchez García
M
M
Duran Giménez-Rico
H J
HJ
Llamas Matías
M A
MA
Arias Pérez
J
J
D000818:Animals; D001284:Atrophy; D003097:Collateral Circulation; D018450:Disease Progression; D006975:Hypertension, Portal / Q000503:physiopathology; D008026:Ligation; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008297:Male; D023421:Models, Animal; D009929:Organ Size; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar