title: Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine.
abstract: 3,5-dihydroxyphenylacetate, a precursor for the non-proteinogenic amino acid 3,5-dihydroxyphenylglycine occurring in glycopeptide antibiotics, is determined to be catalysed by a type III polyketide synthase using malonyl-CoA as a starter unit.
authors.affiliation: Cambridge Centre for Molecular Recognition, Department of Chemistry, Cambridge University, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: T L
authors.initials: TL
authors.lastname: Li
authors.forename: O W
authors.initials: OW
authors.lastname: Choroba
authors.forename: H
authors.initials: H
authors.lastname: Hong
authors.forename: D H
authors.initials: DH
authors.lastname: Williams
authors.forename: J B
authors.initials: JB
authors.lastname: Spencer
mesh_terms: D000192:Actinomycetales / Q000235:genetics / Q000378:metabolism; D002849:Chromatography, Gas; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005998:Glycine / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000737:chemistry; D013058:Mass Spectrometry; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012118:Resorcinols / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000737:chemistry
chemical_list: D009097:Multienzyme Complexes; D012118:Resorcinols; C079215:3,5-dihydroxyphenylglycine; D014640:Vancomycin; D005998:Glycine