Herpes viral proteins manipulating the peptide transporter TAP.
The peptide transporter associated with antigen processing (TAP) is crucial for class I-restricted antigen presentation because it transfers cytosolic peptides into the endoplasmic reticulum (ER) lumen for class I binding. It is therefore not surprising that TAP is targeted for inactivation by many viruses. Herpesviruses have been very successful in designing various proteins that inactivate TAP. We summarise current knowledge on the class I antigen presentation pathway and the function, structure and action of TAP and its viral inhibitors.
Reits
E
E
Division of Tumor Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Griekspoor
A
A
Neefjes
J
J
D000818:Animals; D001693:Biological Transport, Active / Q000276:immunology; D003600:Cytosol / Q000378:metabolism; D006564:Herpesviridae / Q000276:immunology / Q000378:metabolism*; D006566:Herpesviridae Infections / Q000276:immunology* / Q000821:virology; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins; D021381:Protein Transport / Q000276:immunology; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D026901:Membrane Transport Proteins; D014764:Viral Proteins; C043912:peptide permease