Self-assisted tandem Michael-aldol reactions of alpha,beta-unsaturated ketones with aldehydes.
The tandem Michael-aldol reaction of 1-[2-(methylsulfanyl)-phenyl]prop-2-en-1-one (1) or the seleno congener 4 with p-nitrobenzaldehyde in the presence of BF3.Et2O gave the Baylis-Hillman adduct 2 or 5 and onium salt 3 or 6, respectively, and selenochromanone 7 from 4.
Kataoka
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T
Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan. kataoka@gifu-pu.ac.jp
Kinoshita
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S
Kinoshita
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Fujita
M
M
Iwamura
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T
Watanabe
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S