[Allergic vasculitis following ingestion of celecoxib?].
A 76-year-old patient developed cutaneous vasculitis on the lower legs on the 8th day of treatment with the selective cox-2-inhibitor celecoxib (Celebrex((R))) and the proton-pump inhibitor omeprazole. The patient had no history of allergic reactions. The patient had already been treated previously with omeprazole without any side effects. A cutaneous biopsy confirmed the diagnosis of leucocytoclastic vasculitis. The purpuric skin lesions regressed within 3 weeks after withdrawing the two newly introduced drugs. We discuss the potential role of Celecoxib in triggering this vasculitis.
Gscheidel
D
D
Clinique Dermatologique, Strasbourg Cedex, Frankreich, Germany.
Daspet
M K
MK
Le Coz
C J
CJ
Lipsker
D
D
D000284:Administration, Oral; D000368:Aged; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D009853:Omeprazole / Q000008:administration & dosage / Q000009:adverse effects; D054328:Proton Pump Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
D016861:Cyclooxygenase Inhibitors; D054328:Proton Pump Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib; D009853:Omeprazole