title: The Interleukin 1-beta exonic (+3953) polymorphism does not alter in vitro protein secretion.
abstract: Several studies have described polymorphisms in the genes encoding interleukin-1alpha (IL-1alpha) and IL-1beta cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-beta exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays.
authors.affiliation: Institute of Biomedical Sciences, Department of Neurology, Ospedale Luigi Sacco, Milan, Italy
authors.forename: Roberto
authors.initials: R
authors.lastname: Dominici
authors.forename: Giulia
authors.initials: G
authors.lastname: Malferrari
authors.forename: Claudio
authors.initials: C
authors.lastname: Mariani
authors.forename: Luigi
authors.initials: L
authors.lastname: Grimaldi
authors.forename: Ida
authors.initials: I
authors.lastname: Biunno
mesh_terms: D015331:Cohort Studies; D005091:Exons; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D011110:Polymorphism, Genetic; D013997:Time Factors
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides