A multicomponent reaction for the one-pot synthesis of 4-aza-2,3-didehydropodophyllotoxin and derivatives.
[reaction: see text] A convergent method has been found to prepare 4-aza-2,3-didehydropodophyllotoxin and derivatives in a one-pot procedure. The mechanism of the reaction between tetronic acid, anilines, and benzaldehydes is discussed.
Tratrat
Christophe
C
Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à l'Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France.
Giorgi-Renault
Sylviane
S
Husson
Henri-Philippe
HP
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000737:chemistry*; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry*
C467920:4-aza-2,3-didehydropodophyllotoxin; D000970:Antineoplastic Agents; D011034:Podophyllotoxin