Hepatitis e virus infection in fulminant hepatitis patients and an apparently healthy population in Bangladesh.
This is the first study comparing hepatitis E virus (HEV) infection in Bangladesh in fulminant hepatitis (FH) patients presumed to have a viral cause and in the apparently healthy population. Sera from 22 FH patients were analyzed for antibodies to hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C and D viruses, and HEV and for hepatitis B surface antigen (HBsAg). Anti-HEV immunoglobulin M (IgM) was detected in the sera of 63.6% of patients, whereas 35.7% were positive for HBsAg. A high prevalence of HEV infection (83.3%) was noted in the HBV carriers. Serum samples from 273 apparently healthy individuals were tested for antibodies to HAV and HEV. Anti-HEV IgM was detected in 7.3% of the samples. The seroprevalence of HAV differed from that of HEV in the same population because all samples were negative for anti-HAV IgM. These data indicate that HEV infection is highly endemic in Bangladesh.
Sheikh
Aleemuzzaman
A
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan. sheikh@med.nihon-u.ac.jp
Sugitani
Masahiko
M
Kinukawa
Noriko
N
Moriyama
Mitsuhiko
M
Arakawa
Yasuyuki
Y
Komiyama
Kazuo
K
Li
Tian-Cheng
TC
Takeda
Naokazu
N
Ishaque
Shamsuddin M
SM
Hasan
Mahmud
M
Suzuki
Koyu
K
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001459:Bangladesh / Q000453:epidemiology; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000175:diagnosis / Q000453:epidemiology*; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics
D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral