title: Platelets and anticoagulant capacity in patients with inflammatory bowel disease.
abstract: Patients with inflammatory bowel disease (IBD) are susceptible to thromboembolic complications. Several mechanisms can be responsible, including abnormal regulation of coagulation activity, disturbances of fibrinolysis, inflammatory reactions and thrombocytosis. The aim of this study was to assess hemostatic alterations in these parameters during exacerbation of disease. We studied disease activity in 99 IBD patients receiving anti-inflammatory therapy, in relation to: procoagulant markers, i.e. prothrombin fragment F1 + 2 (F1 + 2), D-dimer and platelet count, anticoagulant markers, i.e. protein C, protein S and antithrombin, and a mediator of inflammation (IL-6). Coagulation activity and platelet count were increased during active disease in IBD patients compared with those in a state of remission. The IL-6 concentrations were positively correlated with disease activity and thrombocytosis in patients with ulcerative colitis, but no association with the anticoagulant capacity could be demonstrated except for a decrease in protein C during high disease activity.
authors.affiliation: Department of Clinical Biochemistry, Section for Thrombosis and Hemostasis, Aalborg Hospital, Aalborg, Denmark. tblarsen@dadlnet.dk
authors.forename: Torben Bjerregaard
authors.initials: TB
authors.lastname: Larsen
authors.forename: Jens Nederby
authors.initials: JN
authors.lastname: Nielsen
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Fredholm
authors.forename: Erik D
authors.initials: ED
authors.lastname: Lund
authors.forename: Ivan
authors.initials: I
authors.lastname: Brandslund
authors.forename: Pia
authors.initials: P
authors.lastname: Munkholm
authors.forename: Henrik
authors.initials: H
authors.lastname: Hey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D019774:Blood Coagulation Factor Inhibitors / Q000032:analysis / Q000502:physiology*; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013923:Thromboembolism / Q000209:etiology; D019851:Thrombophilia / Q000097:blood
chemical_list: D015415:Biomarkers; D019774:Blood Coagulation Factor Inhibitors; D015850:Interleukin-6