Analysis of the distribution of binding sites for the plant lectin Bandeiraea simplicifolia I-isolectin B4 on primary sensory neurones in seven mammalian species.
The purpose of the present study was to investigate the binding patterns of the plant lectin Bandeiraea simplicifolia I-isolectin B(4) (BSI-B(4)) to sensory neurones in seven mammalian species. The dorsal root ganglia and spinal cords of three rats, mice, guinea pigs, rabbits, flying foxes, cats, and marmoset monkeys were screened for BSI-B(4) using lectin histochemistry. BSI-B(4) binding was associated with the soma of predominantly small-diameter primary sensory neurones in the dorsal root ganglia and their axon terminals within laminae I and II of the superficial dorsal horn in all seven species. The similarities of lectin binding patterns in each of these species suggest that the glycoconjugate to which BSI-B(4) binds has a ubiquitous distribution in mammals, and supports the proposal that this lectin may preferentially bind to a subpopulation of sensory neurones with a similar functional role in each of these species.
Gerke
Michelle B
MB
Neuroscience Laboratory, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia.
Plenderleith
Mark B
MB
D000818:Animals; D002144:Callithrix; D002415:Cats; D002685:Chiroptera; D005727:Ganglia, Spinal / Q000166:cytology; D006168:Guinea Pigs; D051379:Mice; D009475:Neurons, Afferent / Q000378:metabolism*; D009619:Nociceptors / Q000378:metabolism; D010146:Pain; D037121:Plant Lectins / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013116:Spinal Cord / Q000166:cytology
C045475:Griffonia simplicifolia lectins; D037121:Plant Lectins