Changes in fetoplacental vessel flow velocity waveforms following maternal administration of betamethasone.
OBJECTIVE
To determine the timing of the onset of the umbilical artery flow velocity waveform changes following maternal administration of betamethasone in pregnancies complicated by umbilical artery absent end-diastolic flow, and to explore whether these changes are associated with flow velocity waveform changes in other fetoplacental vessels.


METHODS
This was a prospective study of 12 women with pregnancies complicated by umbilical artery absent end-diastolic flow. Flow velocity waveforms were recorded from the umbilical artery, fetal middle cerebral artery, renal artery, aorta and ductus venosus, before and after maternal betamethasone administration, using real-time pulsed wave Doppler.


RESULTS
In all 12 pregnancies, the administration of maternal betamethasone was followed by the return of end-diastolic flow within 24 h. End-diastolic flow was first observed at 4 h and was present in all women studied at 8 h. In addition, there was a statistically significant decrease in the pulsatility index in the fetal aorta at 8 h and the middle cerebral artery at 24 h. No change was observed in the ductus venosus or the renal artery flow velocity waveforms.


CONCLUSIONS
The findings suggest that, in pregnancies complicated by absent end-diastolic flow in the umbilical artery, maternally administered betamethasone induces a return in umbilical artery end-diastolic flow as early as 4 h, along with widespread vasodilatation throughout the fetoplacental vasculature.
Edwards
A
A
Maternal Fetal Medicine Unit, Monash Medical Centre, Clayton, Victoria, Australia.
Baker
L S
LS
Wallace
E M
EM
D001623:Betamethasone / Q000627:therapeutic use*; D001783:Blood Flow Velocity / Q000187:drug effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D021041:Placental Circulation / Q000187:drug effects*; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D014469:Umbilical Arteries
D005938:Glucocorticoids; D001623:Betamethasone