title: Effect of AGEs on human disc herniation: intervertebral disc hernia is also effected by AGEs.
abstract: Currently, extracellular matrix MMP has been discussed in relation to the extrusion and spontaneous regression of the herniated mass observed in lumbar disc herniation. However, the question remains as to whether degenerated protein is really the cause of this condition's pathogenesis. We confirmed immunologically by means of electron microscopy that extrusion is caused by the AGEs (advanced glycation end products)-induced cross-linking of collagen, and that spontaneous regression is due to AGE receptors on macrophages. Further, AGEs were found to be already exposed during histogenesis, suggesting a relation to apoptosis. In lumbar disc herniation and aging, glucose-derived AGEs cross-link proteins and cause vascular tissue damage.
authors.affiliation: Department of Orthopaedic Surgery, Kurume University School of Medicine, Kurume 830-0011, Japan. michiyo@med.kurume-u.ac.jp
authors.forename: Michiyo
authors.initials: M
authors.lastname: Tsuru
authors.forename: Kensei
authors.initials: K
authors.lastname: Nagata
authors.forename: Atsuo
authors.initials: A
authors.lastname: Jimi
authors.forename: Kouji
authors.initials: K
authors.lastname: Irie
authors.forename: Akira
authors.initials: A
authors.lastname: Yamada
authors.forename: Ryoji
authors.initials: R
authors.lastname: Nagai
authors.forename: Seikoh
authors.initials: S
authors.lastname: Horiuchi
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D001483:Base Sequence; D017931:DNA Primers; D017127:Glycation End Products, Advanced / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D007405:Intervertebral Disc Displacement / Q000503:physiopathology*; D008159:Lumbar Vertebrae; D008854:Microscopy, Electron; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D017127:Glycation End Products, Advanced