Mathematical analysis of solid-liquid mass transfer in a batch reactor for the enzymatic transformation of testosterone to 4AD.
A previous mathematical analysis of mass transfer in a two-phase (solid-liquid) batch reactor for enzymatic transformation of testosterone to 4AD (Pereira et al., 1987) is extended to incorporate the effect of convective mixing. The results of the analysis showed that for a given enzyme loading, the mass transfer resistance in the solid (a function of the bead size) and the intensity of convective mixing (as embodied in the mass transfer coefficient) are two parameters that can be varied such that the overall mass transfer rate from the solid to the liquid phase ensures optimal reactor performance.
Patel
Shwetal
S
Department of Chemical Engineering, Indian Institute of Technology, Bombay, Powai, Bombay 400076, India.
Mehra
Anurag
A
D015067:17-Hydroxysteroid Dehydrogenases; D000734:Androstenediols / Q000378:metabolism*; D019149:Bioreactors; D020604:Comamonas testosteroni / Q000201:enzymology*; D003198:Computer Simulation; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D008954:Models, Biological; D008956:Models, Chemical; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods; D012680:Sensitivity and Specificity; D013739:Testosterone / Q000378:metabolism*
D000734:Androstenediols; C021287:4-androstene-3,17-diol; D013739:Testosterone; D015067:17-Hydroxysteroid Dehydrogenases; D006913:Hydroxysteroid Dehydrogenases; C032690:3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))