title: Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis.
abstract: Twelve taxane diterpenes (1-12), which were isolated previously from the EtOH extract of the aerial parts of Taxus yunnanensis or Taxus chinensis, were evaluated for cytotoxicity against the multidrug resistant cancer cells KB-VIN and KB-7d. Compounds and showed significant cytotoxicity in these cell lines. Compounds and also demonstrated significant activity against KB-7d. The biflavonoid isolated from T. yunnanensis was only marginally cytotoxic against the A549 (lung) cell line, but a simple methoxylated analogue (14) was inactive.
authors.affiliation: Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Shinozaki
authors.forename: Narihiko
authors.initials: N
authors.lastname: Fukamiya
authors.forename: Chieko
authors.initials: C
authors.lastname: Uchiyama
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Okano
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tagahara
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019441:Plant Epidermis / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D043823:Taxoids; D020946:Taxus / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D004224:Diterpenes; D005419:Flavonoids; D043823:Taxoids; C080625:taxane