title: Saline cathartics and adsorptive capacity of activated charcoal for doxycycline.
abstract: The effects of sodium chloride and sodium citrate on the in vitro adsorption of doxycycline to activated charcoal have been studied. Solutions of doxycycline alone and doxycycline with 7.5 mg/ml cathartic solutions were vortex-mixed for 30 s with different quantities of activated charcoal, incubated for 30 min at 37 degrees C and analyzed for free doxycycline spectrophotometrically at 348 nm. Addition of NaCl had a significant (p<0.05) increase while sodium citrate produced a significant (p<0.05) decrease in the adsorption of doxycycline on activated charcoal. In all, the adsorption doxycycline on activated charcoal obeyed quantity-dependent kinetics.
authors.affiliation: Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria. Connice@infoweb.abs.net
authors.forename: O J
authors.initials: OJ
authors.lastname: Afonne
authors.forename: O E
authors.initials: OE
authors.lastname: Orisakwe
authors.forename: S I
authors.initials: SI
authors.lastname: Ofuefule
authors.forename: S
authors.initials: S
authors.lastname: Tsalha
authors.forename: E
authors.initials: E
authors.lastname: Obi
authors.forename: N A
authors.initials: NA
authors.lastname: Ilondu
authors.forename: O
authors.initials: O
authors.lastname: Okorie
mesh_terms: D000327:Adsorption / Q000187:drug effects; D002400:Cathartics / Q000493:pharmacokinetics*; D002606:Charcoal / Q000493:pharmacokinetics*; D004318:Doxycycline / Q000493:pharmacokinetics*; D012965:Sodium Chloride / Q000493:pharmacokinetics*; D012996:Solutions
chemical_list: D002400:Cathartics; D012996:Solutions; D002606:Charcoal; D012965:Sodium Chloride; D004318:Doxycycline