title: 35 years of experimental research in transmyocardial revascularization: what have we learned?
abstract: In the past 35 years many experimental studies have been performed to investigate the revascularization potential of transmyocardial revascularization and the possible working mechanisms underlying the observed clinical improvement in angina pectoris after this treatment. In this review of the experimental literature, the various methods that have been used to create transmyocardial channels and the most supported hypotheses on the working mechanism (channel patency, angiogenesis and myocardial denervation) are discussed and evaluated.
authors.affiliation: Laser Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.huikeshoven@amc.uva.nl
authors.forename: Menno
authors.initials: M
authors.lastname: Huikeshoven
authors.forename: Johan F
authors.initials: JF
authors.lastname: Beek
authors.forename: Jos A P
authors.initials: JA
authors.lastname: van der Sloot
authors.forename: Raymond
authors.initials: R
authors.lastname: Tukkie
authors.forename: Jan
authors.initials: J
authors.lastname: van der Meulen
authors.forename: Martin J C
authors.initials: MJ
authors.lastname: van Gemert
mesh_terms: D000818:Animals; D006352:Heart Ventricles / Q000601:surgery*; D006801:Humans; D053685:Laser Therapy; D017202:Myocardial Ischemia / Q000601:surgery*; D009204:Myocardial Revascularization / Q000379:methods*; D010043:Outcome and Process Assessment, Health Care