title: Inducible AmpC beta-lactamase of a new member Enterobacteriaceae.
abstract: Extensive biochemical testing and 16S rRNA and rpoB sequence analysis revealed that clinical strain CF01Ent1, initially identified as Buttiauxella agrestis by the use of Api 32 biochemical strips, is a new organism in the Enterobacteriaceae family. It produced an inducible AmpC-type beta-lactamase whose sequence shares 69 to 72% identity with those of the other AmpC-type beta-lactamases of ENTEROBACTERIACEAE: This enzyme exhibits an atypical high affinity for all beta-lactams tested.
authors.affiliation: Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, France. richard.bonnet@u-clermont1.fr
authors.forename: Richard
authors.initials: R
authors.lastname: Bonnet
authors.forename: Catherine
authors.initials: C
authors.lastname: Chanal
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ageron
authors.forename: Danielle
authors.initials: D
authors.lastname: Sirot
authors.forename: Christophe
authors.initials: C
authors.lastname: De Champs
authors.forename: Patrick
authors.initials: P
authors.lastname: Grimont
authors.forename: Jacques
authors.initials: J
authors.lastname: Sirot
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D001483:Base Sequence; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004755:Enterobacteriaceae / Q000145:classification* / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004790:Enzyme Induction; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012336:RNA, Ribosomal, 16S; D047090:beta-Lactams; C071526:AmpR protein, Bacteria; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit; C048795:AmpC beta-lactamases; D001618:beta-Lactamases