title: Simultaneous presentation of silicone and silica granuloma: a case report.
abstract: We report a case of a 45-year-old woman who presented a simultaneous foreign-body granuloma reaction to silicone in her face and to silica in the elbow and knee. The patient had received silicone injections in her face 7 years earlier and had suffered a motorcycle accident when she was young. Changes suggestive of silicone were observed in the biopsy obtained from the face, and silica was detected in the biopsy taken from the elbow, confirmed by polarized light and X-ray microanalysis. The presence of polarizable foreign matter in cutaneous epithelioid granulomas should alert to the diagnosis of sarcoidosis.
authors.affiliation: Department of Dermatology, Hospital Santa Creu i Sant Pau, Universitat Autónoma de Barcelona, España, Barcelona, Spain. lpimentel@hsp.sanpau.es
authors.forename: Lucía
authors.initials: L
authors.lastname: Pimentel
authors.forename: Maria
authors.initials: M
authors.lastname: Barnadas
authors.forename: David
authors.initials: D
authors.lastname: Vidal
authors.forename: Francisco
authors.initials: F
authors.lastname: Sancho
authors.forename: Ramon
authors.initials: R
authors.lastname: Fontarnau
authors.forename: Agustín
authors.initials: A
authors.lastname: Alomar
mesh_terms: D003357:Cosmetic Techniques / Q000009:adverse effects; D004577:Electron Probe Microanalysis; D005121:Extremities; D005145:Face; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007267:Injections; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D012822:Silicon Dioxide / Q000009:adverse effects*; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects*; D012867:Skin / Q000473:pathology*
chemical_list: D012828:Silicones; D012822:Silicon Dioxide