title: The incidence of lymphoma in the UK haemophilia population between 1978 and 1999.
abstract: OBJECTIVE
  To determine the incidence of non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) in the UK haemophilia population during the 22 year period 1978-1999.
  
  
  METHODS
  An analysis of patient data included on the UK Haemophilia Centre Doctors' Organisation lymphoma register. The number of cases of NHL and HD occurring in HIV-positive and negative patients in each 3-year period were compared with the expected incidence in the general male population.
  
  
  RESULTS
  Eighty-nine cases of lymphoma were identified. Seventy-two cases (81%) occurred in HIV-positive patients (67 NHL, five HD), and 17 cases (19%) in HIV-negative patients (nine NHL, eight HD). The incidence of NHL in the HIV-positive cohort was significantly increased, with a ratio of observed to expected cases of 83.92 (P < 0.001) in the period 1985-1996. The ratio reduced to 42.15 during the period 1997-1999, presumably as a consequence of the introduction of highly active antiretroviral therapy (HAART). There was a significant excess of HD in HIV-positive patients, with an observed to expected ratio of 10.50 between 1985 and 1999 (based on five cases, P < 0.001). During the whole observation period, there was a significant excess of HD in HIV-negative patients, with an observed to expected ratio of 2.66 (based on eight cases, P < 0.05).
  
  
  CONCLUSIONS
  The incidence of lymphoma is significantly higher in HIV-positive UK haemophilia patients compared with HIV-negative individuals. Since the introduction of HAART, the incidence of lymphoma has tended to fall in the HIV-positive group.
authors.affiliation: Department of Haematology, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham B15 2TH, UK. jonathan.wilde@university-b.wmids.nhs.uk
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Wilde
authors.forename: Christine A
authors.initials: CA
authors.lastname: Lee
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Darby
authors.forename: Sau Wan
authors.initials: SW
authors.lastname: Kan
authors.forename: Paul
authors.initials: P
authors.lastname: Giangrande
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Phillips
authors.forename: Mark
authors.initials: M
authors.lastname: Winter
authors.forename: Rosemary
authors.initials: R
authors.lastname: Spooner
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Ludlam
mesh_terms: D015658:HIV Infections / Q000150:complications*; D006467:Hemophilia A / Q000150:complications*; D006689:Hodgkin Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology*; D008297:Male; D012042:Registries; D006113:United Kingdom / Q000453:epidemiology