The Effect of Tunicamycin on the Interaction of Fibronectin and HT1080 Cells.
We have found that the binding affinity of human plasma Fn to HT1O80 cell treated with TM was 2.61x1O(-8) M, the number of binding sites was 4.24x1O(4)/cell, while those of the control group was 2.50x1O(-8) M and 2.13x1O(5)/cell respectively. These results indicate that, the Fn binding sites on the cell surface decreased by 80% after TM treatment. The binding affinity of FnR in the TM-treated cell did not alter.
Cao
Li-Huan
LH
Department of Biochemistry, Shanghai Medical University, Shanghai 200032, China.
Zha
Xi-Liang
XL