[Effect of enoxacin on pharmacokinetics of theophylline in rats].
In order to obtain an experimental evidence for Enoxacin(ENX) to be correctly used in clinical treatment, we studied the effect of ENX on the pharmacokinetic parameters of theophylline(TP). A single oral dose of TP 20 mg/kg was given to rats and ENX(300 mg/kg, 450 mg/kg) was co-administered orally three times to those rats. The plasma concentrations of TP were determined by HPLC after TP was administered 1, 2, 3, 5, 7, 12 and 24 hrs. The results showed that TP was eliminated by one compartment model. TP plasma concentrations and AUC were significantly increased. T1/2 beta of TP was prolonged. The total clearance of TP was decreased when compared with the control. This interaction was dose-dependent. It was concluded that the interaction between ENX and TP existed. Concomitant use of ENX with TP should be avoided.
Kuang
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X
Department of Pharmacology, School of Basic Medical Sciences, WCUMS, Chengdu 610041.
Liu
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D
Bao
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D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D015365:Enoxacin / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013806:Theophylline / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D015365:Enoxacin; D013806:Theophylline