Velo-cardio-facial syndrome: clinical report of a 70-year-old woman.
A clinical report is presented of a 70-year-old female in whom, after more than 40 years residential psychiatric care, the diagnosis of velo-cardio-facial syndrome (VCFS) was ultimately established; the patient has a 46, XX.ish del (22)(q11.2q11.2)(D(22)S(75)-) karyotype. It is advocated that a rather specific psychopathological profile is present in patients with VCFS, for which the term psychopathological phenotype is introduced, that should include data from genetics, neuropathology, development, psychology, and psychiatry.
Verhoeven
W M A
WM
Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands. wverhoeven@vvgi.nl
Tuinier
S
S
Engelen
J J M
JJ
Hollanders-Crombach
H T M
HT
Curfs
L M G
LM
D000368:Aged; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D001523:Mental Disorders / Q000235:genetics*; D017384:Sequence Deletion