Diastereo- and enantioselective synthesis of alpha,beta-disubstituted gamma-nitro methyl sulfonates.
A novel asymmetric synthesis of highly enantioenriched homotaurine precursors has been developed via diastereo-selective Michael addition of lithiated enantiopure sulfonates to nitroalkenes by using 1,2:5,6-di-O-isopropylidene-alpha-D-allofuranose as chiral auxiliary.
Enders
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Institut für Organische Chemie, RWTH Aachen, Professor-Pirlet-Strasse 1, D-52074 Aachen, Germany. enders@rwth-aachen.de
Berner
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OM
Vignola
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Bats
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