title: [Surgical treatment for advanced gallbladder cancer: indications and limitations].
abstract: We have aggressively performed extensive surgery including major liver resection for advanced gallbladder cancer since 1979. The 5-year survival rates for stage IVa and IVb patients after curative resection were 19% and 6%, respectively. Seven patients in the stage IVa group (n = 69) and one in stage IVb (n = 16) have survived for more than 5 years. The hospital mortality rate including all deaths within and over 30 days of curative operation for stage IV gallbladder cancer was 19%. Although radical resection is the only treatment of choice for advanced gallbladder cancer to obtain long-term survival, there are serious problems in extensive surgery. The most important issue is reduction of the hospital mortality rate. Elucidation of the clinical and molecular characteristics leading to potential long-term survival and development of new strategies for the treatment of recurrent tumors are also important issues.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Nagoya University, Graduate School of Medicine, Nagoya, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Uesaka
authors.forename: Naokazu
authors.initials: N
authors.lastname: Hayakawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Kamiya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kondo
authors.forename: Masato
authors.initials: M
authors.lastname: Nagino
authors.forename: Michio
authors.initials: M
authors.lastname: Kanai
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sano
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Arai
authors.forename: Norihiro
authors.initials: N
authors.lastname: Yuasa
authors.forename: Koji
authors.initials: K
authors.lastname: Oda
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishio
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nimura
mesh_terms: D005706:Gallbladder Neoplasms / Q000401:mortality / Q000601:surgery*; D006801:Humans; D015996:Survival Rate