title: [Biliary stents for reconstruction in bile duct injuries. The role of bile acids].
abstract: Biliary stents, placed either surgically, endoscopically or radiologically are a frequent palliative and/or curative option for treatment of obstructive jaundice. Stones or sludge formation above or inside the stent are of major concern in that they cause dysfunction of the stent that needs prompt replacement. To evaluate the efficacy of ursodeoxycholic acid (UDCA) for long-term management of surgically placed biliary stents after iatrogenic injury, a prospective, controlled, randomized trial was conducted.
  
  
  METHODS
  Patients with biliary tract reconstruction caused by iatrogenic injury that required a transanastomotic stent were randomized into a control group (N: 29) and into a UDCA (15 mg/kg day)-treated group (N: 30). Patients were followed on an external basis and a cholangiogram was obtained to verify stent patency. Liver function tests were also analyzed.
  
  
  RESULTS
  The two groups were compared and no differences were observed. UDCA treated patients had significant elevation of transaminases and alkaline phosphatase. Two patients in the control group and four in the treated group developed lithiasis and/or sludge.
  
  
  CONCLUSIONS
  No advantages were shown with administration of UDCA to maintain the biliary stents patent and to prevent neoformation of lithiasis and/or sludge. We conclude that no benefit is obtained with administration of UDCA to patients with biliary reconstruction and a transanastomotic stent.
authors.affiliation: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, México, D.F.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Mercado
authors.forename: Carlos
authors.initials: C
authors.lastname: Chan
authors.forename: Héctor
authors.initials: H
authors.lastname: Orozco
authors.forename: Gumaro
authors.initials: G
authors.lastname: Cano-Gutiérrez
authors.forename: Erick
authors.initials: E
authors.lastname: Galindo
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Chaparro
authors.forename: Rubén Rodrigo
authors.initials: RR
authors.lastname: Lozano-Salazar
authors.forename: Alvaro
authors.initials: A
authors.lastname: López-Loredo
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000293:injuries* / Q000601:surgery*; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000627:therapeutic use*; D002758:Cholangiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007049:Iatrogenic Disease; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019651:Plastic Surgery Procedures; D015607:Stents; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid