title: [Effect of antibiotic therapy on levels of proinflammatory cytokines: interleukin IL-1, IL-6 and tumor necrosis factor TNF-alpha in serum of patients with Lyme borreliosis].
abstract: We estimated serum concentrations of cytokines: IL-1, IL-6, TNF-alpha in patients with diagnosed Lyme disease treated for 14 days with antibiotics. The detection of proinflammatory cytokines was performed by ELISA tests. The examination was carried out before and after the treatment. The comparison with control group stated statistically significant higher concentration of IL-1, IL-6 and TNF-alpha before and after the treatment. Comparing the concentrations of cytokines after treatment with control group showed normalization only in a few cases. In the majority of cases serum cytokines concentrations remained significantly higher. That is why we conclude that 14-day-therapy with antibiotic in patients with Lyme disease may not be sufficient.
authors.affiliation: Kliniki Chorób Zakaźnych i Neuroinfekcji Akademii Medycznej w Białymstoku.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kondrusik
authors.forename: Renata
authors.initials: R
authors.lastname: Swierzbińska
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Zajkowska
authors.forename: Sławomir A
authors.initials: SA
authors.lastname: Pancewicz
authors.forename: Sambor
authors.initials: S
authors.lastname: Grygorczuk
authors.forename: Teresa
authors.initials: T
authors.lastname: Hermanowska-Szpakowicz
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016207:Cytokines / Q000097:blood*; D004334:Drug Administration Schedule; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008193:Lyme Disease / Q000188:drug therapy* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha