Circulating levels of insulin-like growth factor-I and risk of ovarian cancer.
Insulin-like growth factor (IGF)-I, a mitogenic and anti-apoptotic peptide, has been implicated in the development of several cancers. We hypothesized that high circulating IGF-I concentrations may be associated with an increased risk of ovarian cancer. A case-control study was nested within 3 prospective cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). One hundred thirty-two women with primary invasive epithelial ovarian cancer diagnosed at least 1 year after blood donation were case subjects. For each case, 2 control subjects were selected, matching the case subject on cohort, menopausal status, age and date of recruitment (n = 263). Only women who did not use exogenous hormones at blood donation were included in the study. There was no association between IGF-I concentrations and ovarian cancer risk in the study group as a whole. In analyses restricted to subjects who had developed ovarian cancer at a young age (<55), circulating IGF-I was directly and strongly associated with ovarian cancer risk (OR = 4.97; 95% CI = 1.22-20.2 for the top vs. the bottom IGF-I tertile after adjustment for parity, BMI categories and smoking). There was no significant association of IGF binding protein-3 with ovarian cancer risk. We found a strong direct relationship between circulating IGF-I levels and risk of developing ovarian cancer before age 55. Additional, larger studies of this association are needed to provide more precise estimates of effect.
Lukanova
Annekatrin
A
Hormones and Cancer Group, International Agency for Research on Cancer, Lyon, France.
Lundin
Eva
E
Toniolo
Paolo
P
Micheli
Andrea
A
Akhmedkhanov
Arslan
A
Rinaldi
Sabina
S
Muti
Paola
P
Lenner
Per
P
Biessy
Carine
C
Krogh
Vittorio
V
Zeleniuch-Jacquotte
Anne
A
Berrino
Franco
F
Hallmans
Göran
G
Riboli
Elio
E
Kaaks
Rudolf
R
D000367:Age Factors; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I