Inhibition of angiogenesis by propolis.
Propolis, obtained from honeybee hives, has been used in Oriental folk medicine as an anti-inflammatory, anti-carcinogenic, and immunomodulatory agent. There is considerable evidence suggesting that angiogenesis and chronic inflammation are codependent. Blockage of angiogenesis results in an anti-inflammatory effect. Ethanol (EEP) and ether extracts of propolis (REP), and caffeic acid phenethyl ester (CAPE), an active component of propolis, were examined for their anti-angiogenic activities using the chick embryo chorioallantoic membrane (CAM), and the calf pulmonary arterial endothelial (CPAE) cell proliferation, assays. The presence of EEP, REP and CAPE inhibited angiogenesis in the CAM assay and the proliferation of CPAE cells. The results suggest that anti-angiogenic activities of EEP, REP and CAPE are also responsible for their anti-inflammatory effect.
Song
Yun Seon
YS
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
Park
Eun-Hee
EH
Jung
Kyung Ja
KJ
Jin
Changbae
C
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002109:Caffeic Acids / Q000494:pharmacology; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D002823:Chorion / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D000431:Ethanol; D007641:Keratolytic Agents / Q000494:pharmacology; D008566:Membranes / Q000187:drug effects; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011429:Propolis / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000166:cytology / Q000187:drug effects; D012997:Solvents; D013778:Tetrazolium Salts; D013844:Thiazoles; D014212:Tretinoin / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D002109:Caffeic Acids; D007641:Keratolytic Agents; D012997:Solvents; D013778:Tetrazolium Salts; D013844:Thiazoles; D000431:Ethanol; D014212:Tretinoin; D011429:Propolis; C022616:thiazolyl blue; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol