[Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL].
OBJECTIVE
To investigate the effect of sodium ferulate on the proliferation and lipid peroxidation of aortic smooth muscle cells(SMC).


METHODS
Using experimental models of proliferation of cultured rabbit aortic SMC induced by oxidized-low density lipoprotein, the level of lipoperoxide(LPO) was determined by thiobarbituric acid reactive substance(TBARS) method and 3H-thymidine(3H-TdR) incorporation was used to observe DNA synthesis.


RESULTS
SF markedly reduced the increase of medium LPO and inhibited the 3H-TdR incorporation in a dose-dependent manner.


CONCLUSIONS
SF can inhibit the proliferation of SMC. The inhibitory effect may be related to the inhibition of lipid peroxidation.
Yu
H
H
Basic Medical School of Hubei Medical University, Wuhan 430071.
Hong
J
J
Wu
D
D
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D001013:Aorta, Thoracic; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003373:Coumaric Acids / Q000302:isolation & purification / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits
D003373:Coumaric Acids; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D004247:DNA; C004999:ferulic acid