title: Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam.
abstract: The aqueous extract of Centranthus longiflorus ssp. longiflorus (CLE) was investigated for sedative, anticonvulsant and behaviour modifying activity using thiopental sleeping, caffeine induced convulsion and forced swimming depression tests. When the effects of the aqueous extract of CLE (100 mg/kg) was compared to diazepam, it showed similar sedative and anticonvulsant effects to those produced by diazepam (5 mg/kg).
authors.affiliation: Department of Pharmacology, Atatürk University, Faculty of Medicine, Erzurum, Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Büyükokuroğlu
authors.forename: L O
authors.initials: LO
authors.lastname: Demirezer
authors.forename: Z
authors.initials: Z
authors.lastname: Güvenalp
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine; D000697:Central Nervous System Stimulants; D003863:Depression / Q000517:prevention & control; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D013550:Swimming / Q000523:psychology; D013874:Thiopental / Q000494:pharmacology; D014421:Turkey; D028161:Valerianaceae / Q000737:chemistry* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D002110:Caffeine; D005680:gamma-Aminobutyric Acid; D013874:Thiopental; D000241:Adenosine; D003975:Diazepam