EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.
EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute i.v. EP1572 administration (1.0 microg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.
Broglio
F
F
Department of Internal Medicine, University of Turin, Italy.
Boutignon
F
F
Benso
A
A
Gottero
C
C
Prodam
F
F
Arvat
E
E
Ghè
C
C
Catapano
F
F
Torsello
A
A
Locatelli
V
V
Muccioli
G
G
Boeglin
D
D
Guerlavais
V
V
Fehrentz
J A
JA
Martinez
J
J
Ghigo
E
E
Deghenghi
R
R
D000328:Adult; D000818:Animals; D001667:Binding, Competitive; D004305:Dose-Response Relationship, Drug; D054439:Ghrelin; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007211:Indoles; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D036361:Peptide Hormones / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D014364:Tryptophan / Q000031:analogs & derivatives
D054439:Ghrelin; D007211:Indoles; D009842:Oligopeptides; D036361:Peptide Hormones; C086184:hexarelin; D019382:Human Growth Hormone; C582727:macimorelin; D014364:Tryptophan; D013006:Growth Hormone