New and easy route to primary cyclopropylamines from nitriles.
Starting from readily available substrates, we have developed a new synthesis of primary cyclopropylamines. The reaction involves a cooperative Ti(II)- and Lewis acid-mediated coupling of alkanenitriles with Grignard reagents.
Bertus
P
P
CNRS (UMR 6519), Université de Reims Champagne Ardenne, 51687 Reims, France.
Szymoniak
J
J