title: Applying laboratory research: drug anticipation and the treatment of drug addiction.
abstract: Basic research concerning drug tolerance and withdrawal may inform clinical practice, and vice versa. Three areas that integrate the work of the laboratory and the clinic are discussed: (a) drug overdose, (b) cue exposure treatment of addiction, and (c) pharmacological treatment of withdrawal symptoms. The areas are related in that they indicate the contribution of drug-paired cues to the effects of addictive drugs and the role of Pavlovian conditioning of drug effects in drug tolerance and withdrawal symptoms.
authors.affiliation: Department of Psychology, McMaster University, Hamilton, Ontario, Canada. siegel@mcmaster.ca
authors.forename: Shepard
authors.initials: S
authors.lastname: Siegel
authors.forename: Barbara M C
authors.initials: BM
authors.lastname: Ramos
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D003463:Cues; D062787:Drug Overdose; D005108:Extinction, Psychological; D006801:Humans; D051379:Mice; D051381:Rats; D012646:Self Administration; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000523:psychology* / Q000534:rehabilitation
chemical_list: D002766:Cholecystokinin