[Induction of insulin-like growth factor I expression to mandibular advancement in growing rat condylar cartilage].
It was studied effects of functional mandibular advancement on IGF-I peptide of condylar cartilage of 60 5-week-old male rats. Animals were randomly divided into the experimental and control groups, and the mimic functional appliances were used in experimental group. The rats were killed after 1, 3, 7, 14, 21 and 28 days. The results showed that the condylar cartilage of growing rats expressed IGF-I the strongest in the germinal layer, medial in the transitional layer, and the least in the maturational layer. IGF-I positive cells and their immunoreactive levels increased after 1 week of functional mandibular advancement, and reached the peak level at 2 weeks. The results suggest IGF-I in mandibular condyle of rat is related to its growth and differentiation activity, and changes of condylar IGF-I after functional protrusion are relevant to the histologic changes and cellular functions which indicate their involvement with active bone growth and remodeling.
Luo
S
S
College of Stomatology, West China University of Medical Sciences.
Zhou
Z
Z
D000818:Animals; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008297:Male; D019186:Mandibular Advancement; D008335:Mandibular Condyle / Q000254:growth & development* / Q000378:metabolism; D017289:Orthodontic Appliances, Functional; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D007334:Insulin-Like Growth Factor I