Effects of Inula Britannica on the production of antibodies and cytokines and on T cell differentiation in C57BL/6 mice immunized by ovalbumin.
In this study, we investigated the effects of Inula Britannica on the production of antibodies against ovalbumin, and the differentiation of T cells, in C57BL/6 mice. The oral administration of Inula Britannica suppressed IL-4 and IL-6 production in lymphocytes collected from an inguinal lymph node in the immunized leg. On the other hand, the intraperitoneal administration of Inula Britannica suppressed IgG1 production, the ratio of IFN-gamma+IL-4-/IFN-gamma-IL-4+ cells and cytokine production of IL-6. It was presumed that the effects of Inula Britannica on the production of antibodies were induced by regulation of the balance of Th1 and Th2. Further, IL-4 and IL-6 production by lymphocytes collected from an inguinal lymph node in the immunized leg were suppressed, and therefore production of antibodies was suppressed.
Song
Qing-Hua
QH
Department of Bioregulatory Function, Graduate School of Medicine, The University of Tokyo, Japan. cyong-tky@umin.ac.jp
Kobayashi
Takao
T
Hong
Tie
T
Cyong
Jong-Chol
JC
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects*; D005260:Female; D007074:Immunoglobulin G / Q000187:drug effects / Q000276:immunology; D007274:Injections, Intraperitoneal; D038143:Inula; D007866:Leg; D008198:Lymph Nodes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000276:immunology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
D016207:Cytokines; D007074:Immunoglobulin G; D010936:Plant Extracts; D010047:Ovalbumin