[The role of endogenous modulators of chemoreactivity in the regulation of coronary blood flow].
32 circulatory bands of coronary arteries of 5 pigs were studied. It has been revealed that the bands develop long-term tonic contraction activity in Krebs's solution (30 mM of KCl). In this case adrenalin in concentration of 10(-7) g/ml causes mild relaxation. In concentration of 10(-6) g/ml, it causes obvious relaxation. Trimetazidin and mildronat do not affect tonic contraction of the bands. They can quickly and reversibly increase relaxation effects of adrenaline. The preparations can increase ten-fold beta-adrenoreactivity of smooth muscles. This shows an important role of endogenic sensibilizers of beta-adrenoreceptors in regulation of coronary blood flow in humans.
Sizova
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EN
Viatka State Pedagogical University, 610002, Kirov, 111 Lenin St., Russia.
Tsirkin
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VI
Dvorianskiĭ
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SA
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008763:Methylhydrazines / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000097:blood; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D011247:Pregnancy; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology*; D013552:Swine; D014292:Trimetazidine / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D008763:Methylhydrazines; D018727:Muscarinic Antagonists; D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; C050147:3-(2,2,2-trimethylhydrazine)propionate; D014292:Trimetazidine; D004837:Epinephrine