Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain synaptic plasma membranes and microsomes.
Long-term exposure to AlCl_3 resulted in 57% phospholipid (TPL) content of synaptic plasma membranes from rat brain with significant decrease in the proportion and content of most of the phospholipid classes (32%- decreases was of lesser magnitude for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The microsomal TPL and cholesterol (CHL) content decreased by 74% composition. However, the contents of all phospholipids decreased uniformly by about 70%. fluidized in Al fed rats. The results suggest that long-term exposure of rats to Al can alter the structure/function of synaptic plasma membranes and microsomes.
Pandya
Jignesh D.
JD
Department of Biochemistry, Faculty of Science, M.S.University of Baroda, Vadodara 390 002, India.
Dave
Kunjan R.
KR
Katyare
Surendra S.
SS