title: Detection of measles virus genome in bone-marrow aspirates from adults.
abstract: We investigated the presence of the measles virus genome in order to identify asymptomatic infections in the adult population. Bone-marrow aspirates were obtained from 179 patients, 20-96 years of age, for the diagnosis of malignant diseases (29 with malignant lymphoma, 28 with acute leukaemia, 21 with myelodysplastic syndrome, five with multiple myeloma and 96 with other diseases). The measles virus genome was detected in 17 (9.5%) of 179 individuals by RT-PCR and 28 (15.6%) through hybridization. The genomes detected in bone marrow were all in the same cluster, D5, the strain circulating during the study period, and no evidence of persistent infection was obtained. We conclude that asymptomatic infections of measles virus are common in adults and the presence of the measles virus genome would not be related to the pathogenesis of illness.
authors.affiliation: Laboratory of Viral Infection, Kitasato Institute for Life Sciences, Shirokane 5-9-1, Minato-ku Tokyo 108-8641, Japan3.|Department of Pediatrics, School of Medicine, Keio University, Shinano-Machi 35, Shinjyuku-ku, Tokyo 160-8582, Japan1.
authors.forename: Satomi
authors.initials: S
authors.lastname: Sonoda
authors.affiliation: Department of Internal Medicine, Saiseikai Central Hospital, Mita 1-4-17, Minato-ku, Tokyo 108-0073, Japan2.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kitahara
authors.affiliation: Laboratory of Viral Infection, Kitasato Institute for Life Sciences, Shirokane 5-9-1, Minato-ku Tokyo 108-8641, Japan3.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000821:virology*; D016679:Genome, Viral; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000821:virology; D008223:Lymphoma / Q000150:complications / Q000821:virology; D008457:Measles / Q000150:complications / Q000821:virology; D008459:Measles virus / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000821:virology; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000821:virology; D012367:RNA, Viral / Q000032:analysis
chemical_list: D012367:RNA, Viral