Prognostic factors of secondary ovarian carcinoma.
OBJECTIVE
Although the ovaries are common sites of metastases from a variety of primary neoplasms excluding carcinomas of the genital tract, there were few reports concerning survival and prognostic factors. The objective of this study was to assess the clinical factors affecting survival.


METHODS
Fifty-three secondary ovarian carcinomas excluding metastases from genital tract carcinoma were registered by the Tokai Ovarian Tumor Study Group from 1989 to 1999. FIGO staging was set without considering the pathologic findings of the lymph nodes and the primary tumors.


RESULTS
Twenty-four patients were stage I, 11 were stage II, 16 were stage III, and 2 were stage IV. There were significant differences in the survival curves between the early stages (I and II) and advanced stages (III and IV). The 5-year survival rate for patients without residual tumors was 39.9%, while all patients with residual tumors after surgery died within 33 months. The most frequent primary tumor was large intestinal carcinoma, and the second was gastric carcinoma. The 5-year survival rate for patients with large intestinal primary tumors was significantly better than that with stomach tumors. Multivariate analysis demonstrated that tumor stage and primary tumor sites were significant prognostic factors.


CONCLUSIONS
FIGO staging without considering lymph node involvement and the primary tumor was a significant prognostic factor, and prognostic factors for primary ovarian carcinomas can be applied to secondary ovarian carcinomas. Furthermore, the primary tumor site was also an important prognostic factor for survival.
Kikkawa
Fumitaka
F
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan. kikkawaf@med.nagoya-u.ac.jp
Ino
Kazuhiko
K
Nomura
Seiji
S
Ishikawa
Hisatake
H
Kuzuya
Kazuo
K
Yamamuro
Osamu
O
Kobayashi
Iwao
I
Kawai
Michiyasu
M
Mizutani
Shigehiko
S
D001201:Ascites / Q000473:pathology; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000453:epidemiology / Q000473:pathology; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology; D015996:Survival Rate; D013997:Time Factors