title: Clinical and microbiological analysis of periodontally diseased sites after renal transplant.
abstract: This study compared the clinical and microbiological status of periodontally diseased sites in 42 patients who had a renal transplant and were undergoing immunosuppressive therapy (21 taking azathioprin and corticosteroids [Az-C] and 21 taking cyclosporin-A [Cy-A] with those of 21 systemically healthy matched controls. Probing pocket depth (PPD), bleeding on probing (BOP) and gingival hyperplasia (GH) were measured at 339 sites. Subgingival plaque samples were analyzed for the presence of Porphyromonas gingivalis, Treponema denticola and/or Bacteroides forsythus using the BANA test. Our findings suggest that immunosuppressed patients showed significantly less inflammation and fewer putative anaerobic pathogens using the BANA test, and that patients undergoing therapy with cyclosporin-A have a higher frequency of sites with gingival hyperplasia when compared with patients medicated with azathioprin or corticosteroids.
authors.affiliation: School of Dentistry, University of Ribeirão Preto, São Paulo, Brazil.
authors.forename: Mara L S O
authors.initials: ML
authors.lastname: Vieira
authors.forename: Walter Júnior
authors.initials: WJ
authors.lastname: Martins
authors.forename: Marcio F M
authors.initials: MF
authors.lastname: Grisi
authors.forename: Arthur B Júnior
authors.initials: AB
authors.lastname: Novaes
authors.forename: Sergio L S
authors.initials: SL
authors.lastname: Souza
authors.forename: Sérgio L
authors.initials: SL
authors.lastname: Salvador
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000704:Analysis of Variance; D001379:Azathioprine / Q000627:therapeutic use; D001439:Bacteroides / Q000302:isolation & purification; D001587:Benzoylarginine-2-Naphthylamide; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003124:Colorimetry; D016572:Cyclosporine / Q000627:therapeutic use; D003773:Dental Plaque / Q000382:microbiology; D005260:Female; D005884:Gingival Hemorrhage / Q000145:classification / Q000382:microbiology; D005885:Gingival Hyperplasia / Q000145:classification / Q000382:microbiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000145:classification* / Q000382:microbiology; D010514:Periodontal Pocket / Q000145:classification / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D014208:Treponema / Q000302:isolation & purification
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D001587:Benzoylarginine-2-Naphthylamide; D016572:Cyclosporine; D001379:Azathioprine