Effect of physical activity on the pharmacokinetics of ceftazidime in mice.
BACKGROUND
The aim of the present work was to assess comparatively the pharmacokinetic profile of ceftazidime (CAZ) in trained and non-trained mice.


METHODS
The study was performed on 256 mice divided at random into four groups: long-term physically trained mice with (E1a) and without (E1b) physical activity prior to the administration of CAZ, and untrained mice with (E2a) and without (E2b) physical activity prior to the administration of the antibiotic. CAZ was administered intramuscularly (25 mg/kg) to all mice, and blood samples were obtained at different time points. The plasma concentrations of CAZ were determined by HPLC and analyzed by non-compartmental models.


RESULTS
The area under the curves in groups E1a and E2a (27.3 and 22.9 microg x ml(-1) x h, respectively) were different compared to the other groups [(E1b) = 11.1 and (E2b) = 15.6 microg x ml(-1) x h; p < 0.05]. Differences were observed between the concentration-time of CAZ in E1a compared to E1b, E1a versus E2a, E1a versus E2b, E1b versus E2a and E1b versus E2b (p < 0.05).


CONCLUSIONS
Physical activity performed prior to CAZ administration modified the pharmacokinetic profile of the drug administered to mice.
Rule
R
R
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, Facultad de Ciencias Médicas, UNLP, Buenos Aires, Argentina. robertorule@yahoo.com.ar
Giampieri
J
J
Marchetti
S
S
Prozzi
G
G
Buschiazzo
H
H
de Buschiazzo
P M
PM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002442:Ceftazidime / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular; D008297:Male; D051379:Mice; D009043:Motor Activity; D010805:Physical Conditioning, Animal
D000900:Anti-Bacterial Agents; D002442:Ceftazidime