title: Pancreatic involvement during the early phase of shock.
abstract: BACKGROUND
  There is a lack of data concerning pancreatic involvement during shock.
  
  
  OBJECTIVE
  To evaluate possible pancreatic alterations in the early phase of shock.
  
  
  METHODS
  Twelve consecutive patients with shock were studied within 2 hours from the onset of illness. Seven patients died during the hospital stay: 3 within 4 hours from admission, 3 within 4-8 hours and 1 within 12 hours.
  
  
  METHODS
  Amylase, lipase, C-reactive protein, amyloid A, interleukin 6, procalcitonin and vascular cell adhesion molecule-1 serum concentrations were determined on admission and 4, 8, and 12 hours afterward. All patients underwent imaging studies of the pancreas.
  
  
  RESULTS
  None of the patients developed clinical signs or morphological alterations compatible with acute pancreatitis. Serum amylase levels were above the upper reference limit in 7 patients (58.3%) and serum lipase levels in 2 patients (16.7%; P=0.062). There were no significant differences found between survivors and non-survivors in the serum concentrations of all the proteins studied.
  
  
  CONCLUSIONS
  In patients with shock, amylase seems to be more frequently elevated than lipase. None of the patients showed pancreatic alterations at imaging techniques.
authors.affiliation: Dipartimento di Medicina Interna e Gastroenterologia, Ospedale Sant'Orsola, Università di Bologna, Bologna, Italy. pezzilli@orsola-malpighi.med.unibo.it
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pezzilli
authors.forename: Antonio Maria
authors.initials: AM
authors.lastname: Morselli-Labate
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Romboli
authors.forename: Francesco
authors.initials: F
authors.lastname: Dibenedetti
authors.forename: Margherita
authors.initials: M
authors.lastname: Massa
authors.forename: Marina
authors.initials: M
authors.lastname: Migliori
authors.forename: Bahjat
authors.initials: B
authors.lastname: Barakat
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Merlini
authors.forename: Roberto
authors.initials: R
authors.lastname: Corinaldesi
authors.forename: Gian Vico
authors.initials: GV
authors.lastname: Melzi d'Eril
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000681:Amylases / Q000097:blood; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D008297:Male; D010179:Pancreas / Q000201:enzymology / Q000503:physiopathology*; D012769:Shock / Q000097:blood / Q000201:enzymology / Q000401:mortality / Q000503:physiopathology*
chemical_list: D008049:Lipase; D000681:Amylases