title: [Endothelium-dependent contractile reactions of vascular smooth muscles and content of oxygen free radicals in aging rats].
abstract: Endothelium-dependent and endothelium-independent reactions of vascular smooth muscles were studied in isolated preparations of thoracic part of aorta and portal vein of rats of two age groups--6.8 mo. (control) and 24-26 mo. (old animals). In old rats the disturbances occurred primarily in endothelium-dependent vascular reactions. This age-related dysfunction of endothelium resulted in inhibition of NO-dependent regulation of vascular tone. Age-related changes in the state of plasmic membranes of erythrocytes were established using a method of acid hemolysis. Age-related changes in the levels of active forms of oxygen (.O2-, H2O2, .OH-) and nitrogen (NO2-, NO3-) were determined in the myocardium, aorta, blood plasma and erythrocytes of adult and old animals.
authors.affiliation: A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
authors.forename: M M
authors.initials: MM
authors.lastname: Tkachenko
authors.forename: V F
authors.initials: VF
authors.lastname: Sahach
authors.forename: A V
authors.initials: AV
authors.lastname: Kotsiuruba
authors.forename: O V
authors.initials: OV
authors.lastname: Baziliuk
authors.forename: O M
authors.initials: OM
authors.lastname: Bukhanevych
authors.forename: O F
authors.initials: OF
authors.lastname: Mehed'
authors.forename: L H
authors.initials: LH
authors.lastname: Stepanenko
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D009569:Nitric Oxide / Q000096:biosynthesis*; D011169:Portal Vein / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D014661:Vasoconstriction / Q000502:physiology*
chemical_list: D005609:Free Radicals; D009569:Nitric Oxide