Different effects of methionine-enkephalin on paw edema in two inbred rat strains.
The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (kappa opioid receptors antagonist) and beta-funaltrexamine (mu opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains.
Stanojević
Stanislava
S
Branislav Janković Immunology Research Center, Torlak Institute of Immunology and Virology, 458 Vojvode Stepe, 11152 Belgrade, Yugoslavia. canac@eunet.yu
Radulović
Jelena
J
Kovacević-Jovanović
Vesna
V
Vujić
Vesna
V
Dimitrijević
Mirjana
M
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy; D007700:Kinetics; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D005938:Glucocorticoids; D009292:Narcotic Antagonists; D009270:Naloxone; C051844:norbinaltorphimine; D004744:Enkephalin, Methionine; D009271:Naltrexone; C024524:beta-funaltrexamine; D003907:Dexamethasone; C055382:naltrindole