title: Orientational diffusion reflects fiber structure within a voxel.
abstract: Several new MR techniques have been introduced to infer direction through diffusion in multiple nerve fiber bundles within a voxel. To date, however, there has been no physical model reported to evaluate these methodologies and their ability to determine fiber orientation. In this article a model of diffusion analogous to nerve fibers is presented. Diffusion measurements at multiple closely spaced angles of 15 degrees in samples with different fiber orientations are compared with theoretical calculations for restricted diffusion in cylindrical geometry. Orientational diffusion measurements are shown to reflect fiber geometry and theoretical predictions to within 10%. Simulations of fiber crossings within a voxel suggest fiber orientation does not correspond to the direction of the largest measured diffusion coefficient, but theoretical knowledge of signal decay curves can predict the shape of these diffusion coefficient contours for given fiber orientation probabilities.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Elisabeth A H
authors.initials: EA
authors.lastname: von dem Hagen
authors.forename: R Mark
authors.initials: RM
authors.lastname: Henkelman
mesh_terms: D016880:Anisotropy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008854:Microscopy, Electron; D008953:Models, Anatomic; D009412:Nerve Fibers / Q000648:ultrastructure*