title: Anomalously high cooperativity of oligodeoxycytidylic acid for luminescence resonance energy transfer to lanthanide ions.
abstract: The luminescence of terbium(III) and europium(III) through luminescence resonance energy transfer from mononucleotides and oligodeoxynucleotides is examined. Among mononucleotides, dGMP gives the strongest luminescence of terbium(III), while dTMP and dCMP yield a luminescence intensity of europium(III) that is larger than the other two cases. In the homodeoxydecamers, decadeoxycytidylic acid (dC10) produces the highest intensity for both metals. The anomalously large cooperativity of dC10 is explained by the easiness of deformation of the helical structure to bind lanthanide ions, and a circular dichroism study supports this explanation.
authors.affiliation: Center for Integrated Molecular Systems, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31, Hyoja-Dong, Pohang 790-784, Korea.
authors.forename: Jihee
authors.initials: J
authors.lastname: Lee
authors.forename: Minyoung
authors.initials: M
authors.lastname: Park
authors.forename: Hyung Su
authors.initials: HS
authors.lastname: Son
authors.forename: Sang Bum
authors.initials: SB
authors.lastname: Lee
authors.forename: Hee Cheon
authors.initials: HC
authors.lastname: Lee
authors.forename: Ja Kang
authors.initials: JK
authors.lastname: Ku
authors.forename: Joon Won
authors.initials: JW
authors.lastname: Park
mesh_terms: D002942:Circular Dichroism; D004735:Energy Transfer; D005063:Europium; D007700:Kinetics; D028581:Lanthanoid Series Elements; D008163:Luminescent Measurements; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000032:analysis* / Q000737:chemistry*; D013725:Terbium
chemical_list: D028581:Lanthanoid Series Elements; D009838:Oligodeoxyribonucleotides; C033539:oligodeoxycytidylic acid; D013725:Terbium; D005063:Europium