title: Applications of InterPro in protein annotation and genome analysis.
abstract: The applications of InterPro span a range of biologically important areas that includes automatic annotation of protein sequences and genome analysis. In automatic annotation of protein sequences InterPro has been utilised to provide reliable characterisation of sequences, identifying them as candidates for functional annotation. Rules based on the InterPro characterisation are stored and operated through a database called RuleBase. RuleBase is used as the main tool in the sequence database group at the EBI to apply automatic annotation to unknown sequences. The annotated sequences are stored and distributed in the TrEMBL protein sequence database. InterPro also provides a means to carry out statistical and comparative analyses of whole genomes. In the Proteome Analysis Database, InterPro analyses have been combined with other analyses based on CluSTr, the Gene Ontology (GO) and structural information on the proteins.
authors.affiliation: EBI, Hinxton, Cambridge, UK.
authors.forename: Margaret
authors.initials: M
authors.lastname: Biswas
authors.forename: John F
authors.initials: JF
authors.lastname: O'Rourke
authors.forename: Evelyn
authors.initials: E
authors.lastname: Camon
authors.forename: Gill
authors.initials: G
authors.lastname: Fraser
authors.forename: Alexander
authors.initials: A
authors.lastname: Kanapin
authors.forename: Youla
authors.initials: Y
authors.lastname: Karavidopoulou
authors.forename: Paul
authors.initials: P
authors.lastname: Kersey
authors.forename: Evgenia
authors.initials: E
authors.lastname: Kriventseva
authors.forename: Virginie
authors.initials: V
authors.lastname: Mittard
authors.forename: Nicola
authors.initials: N
authors.lastname: Mulder
authors.forename: Isabelle
authors.initials: I
authors.lastname: Phan
authors.forename: Florence
authors.initials: F
authors.lastname: Servant
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology; D030562:Databases, Protein; D016678:Genome; D015894:Genome, Human; D006801:Humans; D020407:Internet; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology; D020543:Proteome / Q000032:analysis*; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D011506:Proteins; D020543:Proteome