title: Post-partum cerebral angiopathy: repetitive TCD, MRI, MRA, and EEG examinations.
abstract: We report of a woman with post-partum cerebral angiopathy (PCA), in whom we repetitively performed transcranial Doppler sonography (TCD), MR imaging (MRI), and MR angiography (MRA) to evaluate the underlying pathophysiology. A 31-year-old woman, Gemini pregnant, complained of severe throbbing frontal headache four days after an uneventful delivery by Cesarean section. Blurred vision occurred eight days after delivery, followed by three generalized tonic-clonic seizures. Neurological examination revealed a somnolent woman without focal neurological deficits. At the day of the seizures increased flow velocities and disturbed flow were observed in the right posterior and anterior cerebral artery on transcranial Doppler (TCD). MRI showed infra- and supratentorial patchy hyperintensities in T2-weighted images and in the FLAIR sequence. Diffusion-weighted imaging revealed corresponding multi-focal hyperintense areas indicating increased diffusion and MRA showed a diffuse multisegmental narrowing of all pial arteries. MRI at day 10 was completely normal, but MRA still revealed vascular narrowing in the right posterior cerebral artery. General slight flow accelerations in all basal arteries occurred after 10 days and lasted for three weeks. PCA is apparently associated with a vascular narrowing causing cerebral ischemia with increased diffusion. Later reactive cerebral hyperperfusion is observed. Vascular narrowing and cerebral hyperperfusion still persist after MRI has normalized.
authors.affiliation: Department of Neurology, Kiel University Hospital, Germany. peter.zunker@wegmanklinik.ch
authors.forename: Peter
authors.initials: P
authors.lastname: Zunker
authors.forename: Kirstin
authors.initials: K
authors.lastname: Golombeck
authors.forename: Joachim
authors.initials: J
authors.lastname: Brossmann
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Georgiadis
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000328:Adult; D000588:Amines; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001929:Brain Edema / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000473:pathology* / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D002560:Cerebrovascular Circulation; D003509:Cyclohexanecarboxylic Acids; D004453:Echoencephalography; D004461:Eclampsia / Q000175:diagnosis / Q000209:etiology; D005260:Female; D000077206:Gabapentin; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D010121:Oxytocin / Q000627:therapeutic use; D049590:Postpartum Period; D011247:Pregnancy; D012680:Sensitivity and Specificity; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D010121:Oxytocin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D001241:Aspirin