[Effects of ethanol on the pulmonary artery endothelium in rats].
Effects of ethanol on membrane potential and intracellular calcium concentration in intact endothelium of isolated pulmonary arteries were investigated. Ethanol evoked hyperpolarization and biphasic increase in [Ca2+]i in the endothelium due to both Ca2+ release from intracellular stores and Ca2+ entry from extracellular solution. These data allow endothelium-dependent dilation of pulmonary artery evoked by ethanol to be explained.
Marchenko
S M
SM
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D051381:Rats
D000431:Ethanol; D002118:Calcium