The A640G and C242T p22(phox) polymorphisms in patients with coronary artery disease.
Oxidative stress plays a significant role in the pathogenesis of coronary artery disease (CAD). A p22(phox)-based NAD(P)H oxidase acts as a potent superoxide-generating system in the vasculature. We studied the association of the A640G and the C242T polymorphisms with clinical risk factors, endothelial function, and severity of CAD in a cohort of 216 patients referred for coronary angiography. The frequency of p22(phox) genotypes for AA, AG, and GG was 22.5, 52.3, and 25.2%, and for CC, CT, and TT 35.5, 51.3, and 13.2%, respectively. The A640G and the C242T polymorphisms were not associated with severity of CAD and endothelial function. The frequency distribution of the genotypes among patients with or without angiographically significant CAD did not reach statistical significance. Our study does not support a functional role for the A640G or C242T polymorphisms either in the severity of CAD or in determining endothelial function in older men.
Zafari
A Maziar
AM
Division of Cardiology, Emory University, Atlanta, GA 30322, USA. azafari@emory.edu
Davidoff
Madalyn N
MN
Austin
Harland
H
Valppu
Liisa
L
Cotsonis
George
G
Lassègue
Bernard
B
Griendling
Kathy K
KK
D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000235:genetics* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D005006:Ethnicity / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D026901:Membrane Transport Proteins; D009252:NADPH Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D019255:NADPH Oxidases; D005996:Nitroglycerin / Q000494:pharmacology; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000494:pharmacology
D026901:Membrane Transport Proteins; D010750:Phosphoproteins; D014665:Vasodilator Agents; D019255:NADPH Oxidases; C086986:CYBA protein, human; D009252:NADPH Dehydrogenase; D005996:Nitroglycerin