Genetic variability in response to infection: malaria and after.
Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity. And there is growing evidence that other infectious agents have, or are, having the same effect. By integrating further studies of human populations with genetic analyses of susceptibility to murine malaria it should now be possible to determine some of the mechanisms involved in the variation of susceptibility to infectious disease, information which may have important practical implications for both the diagnosis and better management of these conditions.
Weatherall
D J
DJ
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. david.weatherall@imm.ox.ac.uk
Clegg
J B
JB
D000818:Animals; D005075:Biological Evolution; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000502:physiology*; D030342:Genetic Diseases, Inborn; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics*; D006801:Humans; D007239:Infections / Q000235:genetics; D008288:Malaria / Q000235:genetics*; D051379:Mice
D006680:HLA Antigens; D006454:Hemoglobins