title: Alternative splicing in the testes.
abstract: Germ-cell differentiation is an ideal process for studying the effects of alternative splicing and there are examples of alternative splicing of genes involved in gene regulation and signal transduction at every stage of the spermatogenic pathway. A network of testes-specific splicing factor interactions has been uncovered and combining our knowledge of these RNAs and proteins should lead to an understanding of the regulation of alternative splicing and male fertility.
authors.affiliation: Institute of Human Genetics, University of Newcastle upon Tyne, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK. j.venables@ncl.ac.uk
authors.forename: Julian P
authors.initials: JP
authors.lastname: Venables
mesh_terms: D017398:Alternative Splicing; D002454:Cell Differentiation; D005298:Fertility / Q000235:genetics; D005544:Forecasting; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics; D012322:RNA Precursors; D012733:Sex Differentiation; D013091:Spermatogenesis; D013737:Testis / Q000166:cytology / Q000196:embryology / Q000502:physiology*
chemical_list: D009687:Nuclear Proteins; D012322:RNA Precursors