A universal role for MyD88 in TLR/IL-1R-mediated signaling.
The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases. Although originally identified as a myeloid-differentiation marker, MyD88 is now known to play an essential role in the innate immune response of insects and mammals. The generation of MyD88-deficient mice, as well as the identification of MyD88-related proteins and regulators of MyD88 signaling, has revealed new and important insights into the function of MyD88.
Janssens
Sophie
S
Dept of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Ghent University-VIB, K.L. Ledeganckstraat 35, B-9000 Gent, Belgium.
Beyaert
Rudi
R
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D053594:Myeloid Differentiation Factor 88; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D017472:Receptors, Interleukin-1 / Q000378:metabolism / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation; D001425:Bacterial Outer Membrane Proteins; C507779:MYD88 protein, human; D053594:Myeloid Differentiation Factor 88; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; C419843:TLR protein, bacteria