title: The GH-IGF-I axis in children with idiopathic short stature.
abstract: Idiopathic short stature (ISS) is a term used for children in whom the etiology of the short stature is undefined. Investigations of the growth hormone (GH)-insulin-like growth factor I axis have revealed several molecular and endocrinological defects in ISS patients. Abnormalities of GH secretion and action, although not frequent, will help to categorize some children with ISS. Because most diagnostic methods remain crude, however, their modification might be necessary to identify more subtle and yet functionally significant abnormalities of this endocrine axis.
authors.affiliation: Section of Paediatric Endocrinology, Dept of Endocrinology, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK EC1A 7BE.
authors.forename: Joanne C
authors.initials: JC
authors.lastname: Blair
authors.forename: Martin O
authors.initials: MO
authors.lastname: Savage
mesh_terms: D001827:Body Height; D002648:Child; D006130:Growth Disorders / Q000209:etiology*; D019382:Human Growth Hormone / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D009154:Mutation; D011986:Receptors, Somatotropin / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
chemical_list: D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I