Treatment of Staphylococcus epidermidis ventriculo-peritoneal shunt infection with linezolid.
Gram-positive bacterial meningitis frequently complicates ventriculo-peritoneal (VP) shunts used for hydrocephalus. Linezolid, an oxazolidinone, is active against Gram-positive cocci, and has excellent CSF penetration. We present a 22-year-old woman who was cured of a Staphylococcus epidermidis VP shunt infection via shunt removal and intravenous linezolid.
Gill
C J
CJ
Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, MA 02111, USA.
Murphy
M A
MA
Hamer
D H
DH
D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020878:Device Removal; D005260:Female; D006801:Humans; D000069349:Linezolid; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy; D023303:Oxazolidinones / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000628:therapy; D013212:Staphylococcus epidermidis; D017287:Ventriculoperitoneal Shunt
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid