title: Issues of nutritional support for the patient with acute pancreatitis.
abstract: Management strategies in the nutritional support of the patient with acute pancreatitis have changed dramatically over the past 10 years. Prospective randomized trials show that maintaining gut integrity is equally as important as placing the pancreas at rest while inflammation within the gland resolves. In comparison to total parenteral nutrition and gut disuse, enteral feeding attenuates disease severity, reduces oxidative stress, and improves patient outcome. Nasojejunal feeds infused at or below the Ligament of Treitz should be provided to those patients with severe pancreatitis, as identified by a number of standardized scoring systems such as Ranson Criteria, APACHE II, Glasgow, and Imrie scores. Total parenteral nutrition should be reserved only for the patient with severe pancreatitis, initiated 4 to 5 days after peak inflammation in whom intolerance to enteral feeding has been shown and/or enteral access cannot be obtained. Vigilant monitoring is required to assure safe and effective delivery of enteral nutrients.
authors.affiliation: Department of Medicine, University of Louisville School of Medicine, KY 40202, USA. samcclave@louisville.edu
authors.forename: Stephen A
authors.initials: SA
authors.lastname: McClave
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Dryden
mesh_terms: D000208:Acute Disease; D000368:Aged; D006801:Humans; D008297:Male; D018529:Nutritional Support / Q000639:trends; D009765:Obesity / Q000150:complications / Q000628:therapy; D010195:Pancreatitis / Q000150:complications / Q000628:therapy*; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000628:therapy; D014057:Tomography, X-Ray Computed