title: A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers.
abstract: Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.
authors.affiliation: Department of Molecular Human Genetics, Ruhr-University, Universitätsstrasse 150, 44780 Bochum, Germany. rene.goedde@ruhr-uni-bochum.de
authors.forename: Rene
authors.initials: R
authors.lastname: Goedde
authors.forename: Stephen
authors.initials: S
authors.lastname: Sawcer
authors.forename: Stefan
authors.initials: S
authors.lastname: Boehringer
authors.forename: Bianca
authors.initials: B
authors.lastname: Miterski
authors.forename: Eckhart
authors.initials: E
authors.lastname: Sindern
authors.forename: Michael
authors.initials: M
authors.lastname: Haupts
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schimrigk
authors.forename: Alastair
authors.initials: A
authors.lastname: Compston
authors.forename: Joerg T
authors.initials: JT
authors.lastname: Epplen
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005820:Genetic Testing; D015894:Genome, Human; D005858:Germany; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology*
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains