title: [Phase I study of biweekly paclitaxel and carboplatin administration in patients with advanced non-small cell lung cancer].
abstract: A phase I study of a biweekly outpatient regimen composed of carboplatin (CBDCA) and paclitaxel (TXL) was conducted for advanced non-small cell lung cancer. TXL was given in combination with a fixed dose of CBDCA (AUC 3) every 2 weeks. The starting dose of TXL was 100 mg/m2, and the dose was escalated in increments of 20 mg/m2. Three to six patients were allocated to each level. Toxicities were evaluated in the first 4 courses to determine the maximum tolerated dose (MTD). TXL 160 mg/m2 dosages proved to be MTD, and the dose limiting toxicity (DLT) was hematotoxicity (neutropenia). The patients, however, recovered from neutropenia using G-CSF immediately, when G-CSF was used. Gastrointestinal toxicity was well-tolerated. A response was found in 9 out of 20 patients who received 4 courses or more (45%). These results suggest that the recommended dose would be CBDCA (AUC 3) + TXL 140 mg/m2. The biweekly regimen has a high level clinical activity and excellent tolerability, and is suitable for outpatients. We started a phase II study because of these results.
authors.affiliation: First Dept. of Medicine, Kurume University, School of Medicine.
authors.forename: Masao
authors.initials: M
authors.lastname: Ichiki
authors.forename: Toru
authors.initials: T
authors.lastname: Rikimaru
authors.forename: Rumi
authors.initials: R
authors.lastname: Gohara
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oshita
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kamimura
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Hoashi
authors.forename: Takeharu
authors.initials: T
authors.lastname: Koga
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D043823:Taxoids
chemical_list: D043823:Taxoids; D016190:Carboplatin; D017239:Paclitaxel