title: Drugs under investigation for attention-deficit hyperactivity disorder.
abstract: There has been substantial development of pharmacological treatments for attention-deficit hyperactivity disorder (ADHD) recently. The greatest change is the approval of new delivery systems for methylphenidate (MPH) and amphetamine (AMP) that permit once a day dosing. There are also a number of new compounds under development for the disorder, including several non-stimulant agents. These compounds target the noradrenergic, histaminergic and dopaminergic systems. The recent developments in the pharmacological treatment of ADHD should increase therapeutic options and the percentage of individuals with the disorder who can be effectively treated.
authors.affiliation: Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA. jschweit@mprc.umaryland.edu
authors.forename: Julie B
authors.initials: JB
authors.lastname: Schweitzer
authors.forename: Henry H
authors.initials: HH
authors.lastname: Holcomb
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D000069445:Atomoxetine Hydrochloride; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003503:Cyclobutanes / Q000627:therapeutic use; D000077265:Donepezil; D017442:Histamine Agonists / Q000627:therapeutic use; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D000077408:Modafinil; D018697:Nootropic Agents / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D011437:Propylamines / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D003503:Cyclobutanes; D017442:Histamine Agonists; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D011437:Propylamines; D000069445:Atomoxetine Hydrochloride; D000077265:Donepezil; D000077408:Modafinil; C058254:sibutramine