Selectins: lectins that initiate cell adhesion under flow.
Interactions of selectins with cell-surface glycoconjugates mediate tethering and rolling adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped elucidate the molecular details of selectin-ligand interactions, the biosynthetic pathways for constructing selectin ligands, and the biophysical and cell biological features that modulate selectin-dependent rolling under flow.
McEver
Rodger P
RP
Oklahoma Medical Research Foundation, and Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA. rodger-mcever@omrf.ouhsc.edu
D020816:Amino Acid Motifs; D000818:Animals; D002448:Cell Adhesion; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008024:Ligands; D008954:Models, Biological; D011485:Protein Binding; D019087:Selectins / Q000378:metabolism* / Q000502:physiology*
D008024:Ligands; D019087:Selectins