title: Use of recombinant tissue-plasminogen activator in a dog with chylothorax secondary to catheter-associated thrombosis of the cranial vena cava.
abstract: A 4-year-old, castrated male Maltese developed cranial vena caval thrombosis and chylothorax following central venous catheterization for treatment of postoperative sepsis. Vena caval thrombolysis was attempted using recombinant human tissue-plasminogen activator (t-PA). Thrombolytic therapy led to an acute reduction in the size of the caval thrombus and was followed by prompt resolution of the chylothorax. Hemorrhage at the entry sites of a jugular catheter and esophagostomy tube placed at the time of treatment was a dose-limiting complication of t-PA therapy in this dog.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA.
authors.forename: Stuart P
authors.initials: SP
authors.lastname: Bliss
authors.forename: Susan K
authors.initials: SK
authors.lastname: Bliss
authors.forename: H Jay
authors.initials: HJ
authors.lastname: Harvey
mesh_terms: D000007:Abdominal Injuries / Q000601:surgery / Q000662:veterinary; D000818:Animals; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000662:veterinary*; D002916:Chylothorax / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D008297:Male; D011183:Postoperative Complications / Q000662:veterinary; D018805:Sepsis / Q000150:complications / Q000628:therapy / Q000662:veterinary; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014683:Vena Cava, Superior; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D014949:Wounds, Nonpenetrating / Q000601:surgery / Q000662:veterinary
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator