[Effects on ang II receptor antagonist on experimental glomerulosclerosis].
OBJECTIVE
To observe the effects of angiotensin II receptor antagonist losartan in experimental glomerulosclerosis.


METHODS
The 5/6 nephrectomized rats were randomly divided into losartan treatment group and control group, the rats with sham operation served as normal control. Urine proteins were measured in the 2nd, 4th and 6th week after operation, and serum BUN, creatinine, total protein and albumin were measured in the 6th week following operation. Renal pathologic changes were evaluated in the 6th week.


RESULTS
Losartan not only reduced urine protein, serum creatinine and BUN(P < 0.01), but also significantly ameliorated glomerular mesangial proliferation and glomerular sclerosis.


CONCLUSIONS
The results suggest that losartan can retard progression of glomerulosclerosis in 5/6 nephrectomized rats.
Yuan
S G
SG
Department of Nephrology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Liu
R H
RH
Xia
Y C
YC
D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001806:Blood Urea Nitrogen; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000473:pathology; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D009392:Nephrectomy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D057911:Angiotensin Receptor Antagonists; D019808:Losartan