[Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure].
OBJECTIVE
To observe the effect of puerarin on heart function and serum oxidized-LDL(ox-LDL) in patients with chronic cardiac failure.


METHODS
Seventy-eight patients with chronic cardiac failure were randomly divided into two groups, regular group (R) and regular + puerarin group (P). All patients in two groups received conventional treatment with inotropic agents, diuretic, and vasodilator, etc. The patients in the P group took puerarin 400 mg.d-1 for 10 days.


RESULTS
After treatment, the clinical heart function of the patients in the two groups was improved, but there was no significant difference between them; the left ventricular ejection fraction (EF) of patients in the P group was higher than that in the R group(P < 0.05); and serum ox-LDL level was significantly decreased in the P group patients, but that was no change in the R group patients(P < 0.05).


CONCLUSIONS
Puerarin may improve the clinical heart function, increase the left ventricular ejection, meanwhile, it may decrease the level of ox-LDL.
Duan
S
S
Department of Cardiovascular Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Li
Y F
YF
Luo
X L
XL
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007529:Isoflavones / Q000627:therapeutic use*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000502:physiology*
D007529:Isoflavones; D008077:Lipoproteins, LDL; D014665:Vasodilator Agents; C099252:oxidized low density lipoprotein; C033607:puerarin