[Gastroprotective effect of lycopene in acute gastritis induced by hydrocortisone].
Lycopine in a daily dose of 0.2 mg/kg produced a gastroprotector effect on the model of hydrocortisone-induced gastritis in rats. A change in the dosage (toward significant increase or decrease) significantly reduces the gastroprotector effect.
Krylov
I A
IA
Pharmacology Department, Northern State Medical University, Troitskii pr. 51, Archangelsk 163051, Russia.
Buiuklinskaia
O V
OV
Uteshev
D B
DB
Shashkina
M Ia
MIa
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D006854:Hydrocortisone; D007958:Leukocyte Count; D000077276:Lycopene; D008297:Male; D009504:Neutrophils / Q000473:pathology; D051381:Rats
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D002338:Carotenoids; D000077276:Lycopene; D006854:Hydrocortisone