The case for hormone replacement: new studies that should inform the debate.
The Women's Health Initiative found that the risks of hormone replacement therapy (HRT) exceeded its benefits in a large group of older postmenopausal women, but did not consider the efficacy of HRT in relieving vasomotor symptoms. Another recent study found that low-dose HRT was as effective as standard-dose HRT while causing fewer side effects. Smaller studies suggest that HRT may improve depression. HRT is not to be used for cardiovascular risk reduction. Genetic testing may point the way to more rational use of HRT.
Thacker
Holly L
HL
Section of Women's Health, Women's Health Center, The Cleveland Clinic Foundation, OH 44195, USA. thackeh@ccf.org
D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000139:chemically induced / Q000517:prevention & control; D003863:Depression / Q000517:prevention & control; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage* / Q000627:therapeutic use; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors
D004966:Estrogens, Conjugated (USP); D017258:Medroxyprogesterone Acetate