Allogeneic peripheral blood stem cell transplantation in beta-thalassemia.
Six transfusion-dependent beta-thalassemia major patients were treated with allogeneic peripheral blood stem cell (PBSC) transplant. The donors were HLA identical siblings except one donor who was a father with one-antigen mismatch of HLA-B loci. The donors were mobilized with G-CSF and PBSC was infused without manipulation. Engraftment was documented in all patients. Acute graft versus host disease (GvHD) was present in 4 patients but could be controlled with steroid or/and ATG. One patient died of hepatic veno-occlusive disease (HVOD) and survivors were all transfusion independent (ex-thalassemia). Chronic GvHD occurred in one patient. Allogeneic PBSC transplantation could achieve disease-free survival in beta-thalassemia major patients.
Fang
Jianpei
J
Department of Pediatrics, Sun Yat-sen Memorial Hospital, Zhong Shan (Sun Yat-sen) University, Guangzhou, People's Republic of China. infor@gdtc.net
Huang
Shaoling
S
Chen
Chun
C
Zhou
Dunhua
D
Wu
Yanfeng
Y
Bao
Rong
R
D000293:Adolescent; D000328:Adult; D001782:Blood Donors / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006648:Histocompatibility; D006801:Humans; D008297:Male; D009679:Nuclear Family; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D012189:Retrospective Studies; D014184:Transplantation, Homologous / Q000276:immunology / Q000379:methods; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000150:complications / Q000628:therapy*