title: ProDom: automated clustering of homologous domains.
abstract: The ProDom database is a comprehensive set of protein domain families automatically generated from the SWISS-PROT and TrEMBL sequence databases. An associated database, ProDom-CG, has been derived as a restriction of ProDom to completely sequenced genomes. The ProDom construction method is based on iterative PSI-BLAST searches and multiple alignments are generated for each domain family. The ProDom web server provides the user with a set of tools to visualise multiple alignments, phylogenetic trees and domain architectures of proteins, as well as a BLAST-based server to analyse new sequences for homologous domains. The comprehensive nature of ProDom makes it particularly useful to help sustain the growth of InterPro.
authors.affiliation: SWISSPROT Group, EBI.
authors.forename: Florence
authors.initials: F
authors.lastname: Servant
authors.forename: Catherine
authors.initials: C
authors.lastname: Bru
authors.forename: Sébastien
authors.initials: S
authors.lastname: Carrère
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Courcelle
authors.forename: Jérĵme
authors.initials: J
authors.lastname: Gouzy
authors.forename: David
authors.initials: D
authors.lastname: Peyruc
authors.forename: Daniel
authors.initials: D
authors.lastname: Kahn
mesh_terms: D030562:Databases, Protein; D016678:Genome; D007255:Information Services; D020407:Internet; D008958:Models, Molecular; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000145:classification; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D014584:User-Computer Interface
chemical_list: D011506:Proteins