The physiological role of dehydroascorbic acid.
Dehydroascorbic acid (DHA) is abundant in the human diet and also is generated from vitamin C (ascorbic acid, AA) in the lumen of the gastrointestinal tract. DHA is absorbed from the lumen of the small intestine and reduced to AA, which subsequently circulates in the blood. Utilization of AA as an antioxidant and enzyme cofactor causes its oxidation to DHA in extracellular fluid and cells. DHA has an important role in many cell types because it can be used to regenerate AA. Both physiological (e.g. insulin, insulin-like growth factor I, cyclic AMP) and pathological (e.g. oxidative stress, diabetes, sepsis) factors alter the transport and metabolic mechanisms responsible for this DHA recycling.
Wilson
John X
JX
Department of Physiology, Faculty of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5C1. john.wilxon@fmd.uwo.ca
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001692:Biological Transport; D003683:Dehydroascorbic Acid / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D010084:Oxidation-Reduction; D015427:Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D018805:Sepsis / Q000378:metabolism* / Q000503:physiopathology
D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid