title: [Myoclonic-astatic epilepsy in early childhood: review of clinical signs, EEG features, etiology, and therapy].
abstract: Myoclonic-astatic epilepsy in early childhood: review of topical knowledge of clinical signs, electroencephalographic characteristics, etiology and therapy. The classification of epilepsy in childhood is discussed continuously. On the basis of some selected cases, the clinical and electrophysiological characteristics of myoclonic-astatic epilepsy in early childhood are described. On the one side we describe similarities of this entity and on the contrary side variabilities of the individual cases. New molecular results are described as possible reasons of the individual course of this disease. The topical options regarding therapy are prescribed.
authors.affiliation: Universitäts-Kinderspital beider Basel (UKBB) Abteilung für Neuropädiatrie. weberp1@tiscalinet.ch
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: B
authors.initials: B
authors.lastname: Tillmann
authors.forename: J-C
authors.initials: JC
authors.lastname: Minet
authors.forename: U
authors.initials: U
authors.lastname: Blauenstein
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D004831:Epilepsies, Myoclonic / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006867:Hydrolases / Q000235:genetics; D007223:Infant; D008297:Male; D009154:Mutation / Q000235:genetics; D062550:NAV1.1 Voltage-Gated Sodium Channel; D062551:NAV1.2 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins / Q000235:genetics; D015222:Sodium Channels / Q000235:genetics
chemical_list: D000927:Anticonvulsants; D062550:NAV1.1 Voltage-Gated Sodium Channel; D062551:NAV1.2 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins; C568242:SCN1A protein, human; C568251:SCN2A protein, human; D015222:Sodium Channels; D006867:Hydrolases; C074369:thiocyanate hydrolase