title: Circadian blood pressure overswinging in a physically fit, normotensive African American woman.
abstract: Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian BP variation, which exceeded gender- and age-specified limits, indicative of circadian hyperamplitude tension (CHAT). A 12-week treatment with the beta1-adrenoceptor blocker atenolol, 14 months post-training, normalized CHAT and HR variability and further reduced BP and HR. These results suggest beta1-adrenergic mediation of CHAT and its refractoriness to exercise training.
authors.affiliation: Division of Kinesiology, University of Michigan, Ann Arbor 48109-2214, USA. katarina@umich.edu
authors.forename: Katarina T
authors.initials: KT
authors.lastname: Borer
authors.forename: Germaine
authors.initials: G
authors.lastname: Cornelissen
authors.forename: Franz
authors.initials: F
authors.lastname: Halberg
authors.forename: Robert
authors.initials: R
authors.lastname: Brook
authors.forename: Sanjay
authors.initials: S
authors.lastname: Rajagopalan
authors.forename: William
authors.initials: W
authors.lastname: Fay
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use*; D044383:Black People; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D017698:Postmenopause; D001741:Black or African American
chemical_list: D000319:Adrenergic beta-Antagonists; D001262:Atenolol