Vitamin C induced decomposition of lipid hydroperoxides: direct evidence of genotoxin-DNA binding detected by QCRS.
We report direct evidence for human DNA-binding to precursors of mutagenic lesion-inducing compounds, produced form the vitamin C induced decomposition of lipid hydroperoxides, using a quartz crystal resonant sensor assay.
Pavey
K D
KD
School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, UK BN2 4GJ. K.D.Pavey@bton.ac.uk
Miah
M
M
Fucassi
F
F
Paul
F
F
Cragg
P J
PJ
D001205:Ascorbic Acid / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D011791:Quartz; D013997:Time Factors
D008054:Lipid Peroxides; D009153:Mutagens; D011791:Quartz; D004247:DNA; D001205:Ascorbic Acid