Phase 1 clinical study of cyclophilin B peptide vaccine for patients with lung cancer.
Cyclophilin B (CypB) possesses two antigenic epitopes (CypB(84-92) and CypB(91-99) ) recognized by HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes (CTLs). To determine the safety of CypB-derived peptides and its ability to generate antitumor immune responses, patients with advanced lung cancer received subcutaneous vaccinations of these peptides or their modified peptides. All 16 patients were vaccinated with CypB(91-99) or its modified peptide, whereas only two patients were vaccinated with the modified CypB(84-92), as immediate-type hypersensitivity to CypB(84-92) or its modified peptide was observed in the remaining patients. No severe adverse events were associated with the vaccination. No significant increase in cellular responses to either peptides or tumor cells was observed in the postvaccination PBMCs by the conventional CTL assays in any patients tested. These results suggest that the vaccination of CypB(91-99) peptide was safe, but failed to induce objective immune responses at this regimen.
Gohara
Rumi
R
Department of Internal Medicine, Kurume University School of Medicine, Japan.
Imai
Nobue
N
Rikimaru
Toru
T
Yamada
Akira
A
Hida
Naoya
N
Ichiki
Masao
M
Kawamoto
Mayumi
M
Matsunaga
Kazuko
K
Ashihara
Junko
J
Yano
Sayoko
S
Tamura
Mayumi
M
Ohkouchi
Shinya
S
Yamana
Hideaki
H
Oizumi
Kotaro
K
Itoh
Kyogo
K
D000328:Adult; D000368:Aged; D019496:Cancer Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D021983:Cyclophilins / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008175:Lung Neoplasms / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019696:Peptidylprolyl Isomerase; D012449:Safety; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000627:therapeutic use
D019496:Cancer Vaccines; D014614:Vaccines, Synthetic; C081786:cyclophilin B; D021983:Cyclophilins; D019696:Peptidylprolyl Isomerase