Human herpesvirus 8 gene encodes a functional thymidylate synthase.
We demonstrate that human herpesvirus 8, obtained from the lymphoma cell line BC-3 as well as from Kaposi's sarcoma lesions, carries a gene that encodes a functional thymidylate synthase (TS). The particular characteristics of this enzyme are studied and compared to the characteristics of TSs encoded by other organisms.
Gáspár
Gábor
G
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
De Clercq
Erik
E
Neyts
Johan
J
D000595:Amino Acid Sequence; D003856:Deoxyuracil Nucleotides / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005468:Fluorodeoxyuridylate / Q000494:pharmacology; D005814:Genes, Viral; D014645:Herpesvirus 3, Human / Q000201:enzymology / Q000235:genetics; D019288:Herpesvirus 8, Human / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D008223:Lymphoma; D008969:Molecular Sequence Data; D012514:Sarcoma, Kaposi / Q000473:pathology / Q000821:virology*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D003856:Deoxyuracil Nucleotides; D004791:Enzyme Inhibitors; D005468:Fluorodeoxyuridylate; C056075:iododeoxyuridylate; D013940:Thymidylate Synthase