title: 2,5-Pyridinedicarboxylic acid derivatives as non-nucleosidic reverse transcriptase inhibitors of hepatitis B virus.
abstract: 2,5-Pyridinedicarboxylic acid derivatives were found to be the potent non-nucleoside inhibitors of hepatitis B virus (HBV) with IC(50) <or=0.01 microg/mL in a reverse transcriptase inhibitory effect. And they showed the low toxicity compared with the nucleoside analogues.
authors.affiliation: Central Research Laboratory, DongWha Pharm. Ind. Co. Ltd., Seoul, South Korea.
authors.forename: JinSoo
authors.initials: J
authors.lastname: Lee
authors.forename: HyungSoo
authors.initials: H
authors.lastname: Shim
authors.forename: YongKyun
authors.initials: Y
authors.lastname: Park
authors.forename: SangJin
authors.initials: S
authors.lastname: Park
authors.forename: JoonSu
authors.initials: J
authors.lastname: Shin
authors.forename: WangYong
authors.initials: W
authors.lastname: Yang
authors.forename: HakDong
authors.initials: H
authors.lastname: Lee
authors.forename: WhuiJung
authors.initials: W
authors.lastname: Park
authors.forename: YongHo
authors.initials: Y
authors.lastname: Chung
authors.forename: SangWook
authors.initials: S
authors.lastname: Lee
mesh_terms: D002460:Cell Line; D006515:Hepatitis B virus / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007202:Indicators and Reagents; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D007202:Indicators and Reagents; D011725:Pyridines; D018894:Reverse Transcriptase Inhibitors; C043093:2,5-Pyridinedicarboxylic acid