title: Lymphangioma circumscriptum of the vulva following surgical and radiological therapy of cervical cancer.
abstract: BACKGROUND
  Lymphangioma circumscriptum of the vulva rarely develops after postoperative pelvic irradiation.
  
  
  OBJECTIVE
  The goal was to describe two cases of lymphangioma circumscriptum and their treatment and present a brief review of the literature.
  
  
  METHODS
  Two female patients, aged 75 years and 46 years, presented with persistent edema, papules, and vesicles of the labia majora, which had developed 15 and 9 years after hysterectomy, lymph node dissection, and subsequent irradiation of cervical cancer. The external diagnosis was genital warts.
  
  
  RESULTS
  In both cases histology revealed lymphangioma circumscriptum of the vulva. Whereas the older woman's condition responded well to laser treatment, keloids developed in the second patient at the site of carbon dioxide laser vaporization.
  
  
  CONCLUSIONS
  CO2 laser treatment recently has been recommended for vulvar lymphangioma circumscriptum and is effective in vaporizing the communicating vessels to deeper cisterns. To our knowledge this is the first description of keloid development after laser therapy for vulvar lymphangioma circumscriptum, and such an effect should be considered before CO2 laser surgery is applied for this particular entity.
authors.affiliation: Department of Dermatology and Venereology, University of Heidelberg, Germany. Uta_Jappe@med.uni-heidelberg.de
authors.forename: Uta
authors.initials: U
authors.lastname: Jappe
authors.forename: Thomas
authors.initials: T
authors.lastname: Zimmermann
authors.forename: Birgit
authors.initials: B
authors.lastname: Kahle
authors.forename: Detlef
authors.initials: D
authors.lastname: Petzoldt
mesh_terms: D000368:Aged; D002245:Carbon Dioxide; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007627:Keloid / Q000209:etiology; D053685:Laser Therapy / Q000009:adverse effects; D008202:Lymphangioma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D014844:Vulva / Q000473:pathology / Q000601:surgery; D014845:Vulvar Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery; D014846:Vulvar Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery
chemical_list: D002245:Carbon Dioxide