Cathelicidins, essential gene-encoded mammalian antibiotics.
Cathelicidins are a class of gene-encoded antibiotics found exclusively in mammals. In vitro and in vivo studies indicate they are effector molecules of mammalian innate immunity that can provide a first line of defense against an array of micro-organisms. Additional functions are described for some members of this class of antimicrobial peptides including chemotactic activity, mitogenesis, and angiogenesis. Therefore these peptides are considered to be multifunctional effector molecules. This review discusses recent progress in cathelicidin research and the functional properties of cathelicidins. Current work in this field suggests that understanding this component of the mammalian innate immune system and related natural antibiotic peptides offer an opportunity for the development of novel therapeutic agents with which to battle the continued problem of antimicrobial resistance.
Zaiou
Mohamed
M
Department of Medicine (Dermatology), University of California, San Diego, CA 92161, USA. Mohamed.Zaiou@med.va.gov
Gallo
Richard L
RL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D001770:Blood Bactericidal Activity; D017124:Conserved Sequence; D005786:Gene Expression Regulation; D020043:Genes, Essential; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D010802:Phylogeny; D011498:Protein Precursors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D011498:Protein Precursors