Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice.
To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.
Hashimoto
Takashi
T
Division of Life Science, Graduate School of Science and Technology, Kobe University, Japan.
Nonaka
Yuji
Y
Minato
Ken-ichiro
K
Kawakami
Sachiko
S
Mizuno
Masashi
M
Fukuda
Itsuko
I
Kanazawa
Kazuki
K
Ashida
Hitoshi
H
D000363:Agaricales / Q000737:chemistry*; D000364:Agaricus / Q000737:chemistry*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D019363:Cytochrome P-450 CYP1A1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D007912:Lentinan / Q000494:pharmacology; D020074:Lentinula / Q000737:chemistry*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*
D065607:Cytochrome P-450 Enzyme Inhibitors; D011134:Polysaccharides; D007912:Lentinan; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D019363:Cytochrome P-450 CYP1A1