Insulin, insulin-like growth factor-1, and insulin resistance in women with pregnancy-induced hypertension.
OBJECTIVE
The purpose of this study was to assess insulin, insulin sensitivity, and insulin-like growth factor-I in women with preeclampsia and gestational hypertension.


METHODS
Insulin resistance was measured with the short insulin-tolerance test in 20 women with preeclampsia, in 18 women with gestational hypertension, and in 20 normotensive control subjects. Sex hormone binding globulin, insulin-like growth factor-I, glucose, fructosamine, glycosylated hemoglobin, insulin, C-peptide, and lipids were measured in the fasting state.


RESULTS
Women with gestational hypertension had a significant lower insulin sensitivity index (0.13 +/- 0.1) and a higher level of insulin-like growth factor-I (333.71 +/- 107.6 ng/mL) than women in the control group (0.21 +/- 0.1 [P <.05]; 218.11 +/- 82.3 ng/mL [P <.01]) and women with preeclampsia (0.21 +/- 0.12 [P <.05]; 234.78 +/- 92.76 ng/mL [P <.01]). There were no significant correlations between insulin sensitivity index and insulin-like growth factor-I.


CONCLUSIONS
Insulin resistance is present in women with gestational hypertension but not in women with preeclampsia and did not correlate with insulin-like growth factor-I.
Bartha
Jose L
JL
Department of Obstetrics and Gynecology University Hospital of Puerto Real, Spain.
Romero-Carmona
Raquel
R
Torrejon-Cardoso
Rafael
R
Comino-Delgado
Rafael
R
D000328:Adult; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008055:Lipids / Q000097:blood; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism*; D011446:Prospective Studies
D007328:Insulin; D008055:Lipids; D007334:Insulin-Like Growth Factor I