Pharmacological studies and synthesis of morpholino alkyl derivatives.
Seven morpholin derivatives were synthesized (compounds 1-7) and their behavioural effects were evaluated; the elements considered were locomotor activity, motor coordination, catalepsy, stereotyped behaviour and antinociception. All the compounds, at doses of 10-20-40 mg/kg/i.p., induced a reduction of all behavioural elements without a significant antinociceptive effect. These results indicate that these morpholin derivatives affect the central nervous system.
Saturnino
Carmela
C
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano-Salerno, Italy.
Capasso
Anna
A
Lancelot
Jean-Chanles
JC
Rault
Sylvain
S
Buonerba
Mariafrancesca
M
De Martino
Giovanni
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D006120:Grooming / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D002491:Central Nervous System Agents; D007202:Indicators and Reagents; D009025:Morpholines