Regulation of surface expression of the human pre-T cell receptor complex.
Considerable progress has recently been made in defining the role that pre-antigen receptor complexes, namely the pre-T and pre-B cell receptors, play in lymphocyte development. It is now established that these receptors direct, in a similar way, the survival, expansion, clonality and further differentiation of pre-T and pre-B lymphocytes, respectively. However, less is known about the mechanisms which ensure that only minute amounts of pre-TCR and pre-BCR reach the plasma membrane of developing lymphocytes. In this review, we discuss the implications of recent experimental approaches which address the developmental regulation of human pre-TCR expression and the molecular mechanisms that control surface pre-TCR expression levels.
Carrasco
Yolanda R
YR
Centro de Biología Molecular Severo Ochoa, CSIC, Facultad de Biología, Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain.
Navarro
María N
MN
de Yébenes
Virginia G
VG
Ramiro
Almudena R
AR
Toribio
María L
ML
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D002462:Cell Membrane / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology*; D011499:Protein Processing, Post-Translational; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D014158:Transcription, Genetic / Q000235:genetics
D008562:Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; C090377:pre-T cell receptor alpha