title: Effects of the Des-F(6)-quinolone garenoxacin (BMS-284756), in comparison to those of ciprofloxacin and ofloxacin, on joint cartilage in immature rats.
abstract: We did not observe signs of chondrotoxicity in immature rats treated orally with garenoxacin (BMS-284756) at doses up to five times 600 mg/kg of body weight or with ciprofloxacin, whereas ofloxacin induced typical cartilage lesions. The peak plasma garenoxacin concentration was 25.5 mg/liter after administration of a dose of 600 mg/kg once daily for 5 days. Assuming that this model is predictive of human risk, BMS-284756 and ciprofloxacin should be more suitable for pediatric use than ofloxacin.
authors.affiliation: Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, Freie Universität Berlin, Germany.
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Kappel
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shakibaei
authors.forename: Akintunde
authors.initials: A
authors.lastname: Bello
authors.forename: Ralf
authors.initials: R
authors.lastname: Stahlmann
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000633:toxicity*; D002357:Cartilage Diseases / Q000139:chemically induced*; D002358:Cartilage, Articular / Q000473:pathology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000633:toxicity*; D024841:Fluoroquinolones; D007211:Indoles; D007719:Knee Joint / Q000473:pathology*; D015242:Ofloxacin / Q000008:administration & dosage / Q000633:toxicity*; D015363:Quinolones; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007211:Indoles; D015363:Quinolones; D002939:Ciprofloxacin; D015242:Ofloxacin; C419689:garenoxacin