title: Lack of reported mutations in a Japanese case of toxic multinodular goiter.
abstract: We describe a toxic multinodular goiter that was subjected to genomic sequencing of the thyroid-stimulating hormone receptor and the alpha-subunit of the stimulatory guanine nucleotide-binding protein. No mutation was detected in either gene. While frequent occurrence of thyroid-stimulating hormone receptor gene mutations in toxic multinodular goiters has been reported in areas such as part of Europe with a relatively high prevalence of iodine deficiency, toxic multinodular goiters in areas with an abundance of dietary iodine such as Japan seem unlikely to involve mutations of this gene.
authors.affiliation: Department of Otolaryngology, Division of Head and Neck Surgery, Shiga University of Medical Science, Otsu, Japan. hanamitu@belle.shiga-med.ac.jp
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hanamitsu
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeuchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitanishi
authors.forename: Hironori
authors.initials: H
authors.lastname: Sakurai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kitano
mesh_terms: D000368:Aged; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D006044:Goiter, Nodular / Q000150:complications / Q000235:genetics*; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology / Q000235:genetics*; D007564:Japan; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D011989:Receptors, Thyrotropin / Q000235:genetics
chemical_list: D011989:Receptors, Thyrotropin; D019205:GTP-Binding Protein alpha Subunits, Gs