title: Twenty-six week carcinogenicity study of ampicillin in CB6F1-TgrasH2 mice.
abstract: As a part of the ILSI-HESI Alternative to Carcinogenicity Testing (ACT) program, we performed a 26-week carcinogenetic study of nonmutagenic drug, ampicillin (ABPC) in Tg-rasH2 mice. ABPC was given to Tg-rasH2 mice (0, 350, 1000, 3000 mg/kg, p.o.) and Non-Tg mice (0, 3000 mg/kg, p.o.) daily for 26 weeks. As a positive control, a single dose of MNU was administered once to Tg-rasH2 mice (75 mg/kg, i.p.). In this study, Tg-rasH2 mice did not demonstrate any increases in tumor development in response to ABPC. Thus, ABPC had no carcinogenicity in the 26-week carcinogenesis study in Tg-rasH2 mice or in a 2-year carcinogenesis study in B6C3F1 mice.
authors.affiliation: Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89 Kashima, Yodogawa-ku, Osaka 532-8505, Japan.
authors.forename: Tamiko
authors.initials: T
authors.lastname: Adachi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuwamura
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tanimoto
authors.forename: Tomonari
authors.initials: T
authors.lastname: Nishimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Koguchi
authors.forename: Kinji
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Chisato
authors.initials: C
authors.lastname: Yamaguchi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Honda
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kawashima
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yuasa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Yamamura
authors.forename: Toshihide
authors.initials: T
authors.lastname: Inui
mesh_terms: D000284:Administration, Oral; D000667:Ampicillin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D011905:Genes, ras; D008136:Longevity / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D010406:Penicillins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D010406:Penicillins; D000667:Ampicillin