An artificial guanine that binds cytidine through the cooperative interaction of metal coordination and hydrogen bonding.
Cd(II) complex of L binds selectively to cytidine in DMSO with an equilibrium constant of 117 M-1 (where LH is 2-aminomethyl-8-hydroxyquinoline). In contrast, the Zn(II) complex of L does not bind appreciably to any of the four nucleobases under the same condition used for the Cd(II) complex.
Mancin
Fabrizio
F
Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, Canada M5S 3H6.
Chin
Jik
J
D002104:Cadmium / Q000737:chemistry* / Q000378:metabolism; D003562:Cytidine / Q000737:chemistry* / Q000378:metabolism; D006147:Guanine / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D007700:Kinetics; D008958:Models, Molecular; D018716:Molecular Mimicry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism
D009942:Organometallic Compounds; D002104:Cadmium; D003562:Cytidine; D006147:Guanine