title: [An elderly non-Hodgkin lymphoma patient with a massive tumor of the heart].
abstract: We report on an elderly patient with a malignant lymphoma forming a huge mass in the heart. An 82-year-old woman became aware of general fatigue and a cough in August 1999. Her right supraclavicular, bilateral axillary, and right inguinal lymph nodes were swollen. A hypodermical mass in the right frontal chest was detected. Her left axillary lymph node was biopsied. She was diagnosed as having non-Hodgkin lymphoma, diffuse large cell type, B-cell type. Computed tomography scans showed a markedly thickened right ventricular wall of the heart, swollen lymph nodes of the mediastinum, bilateral pleural effusions, and a tumor in the spleen. Lymphoma cells were found in the pleural effusion, and the lymphoma was diagnosed as clinical stage IV. Hypofunction of the heart, ejection fraction (EF) 49%, was demonstrated with transthoracic echocardiography. EF increased to 70% after 3 courses of chemotherapy with CHOP regimen. All lesions disappeared after 6 courses of chemotherapy were completed. After consolidative radiotherapy with a total dose of 37 Gy to the mediastinum and heart, bilateral pleural effusions, elevation of the patient's lactate dehydrogenase level and soluble IL-2 receptor value were recognized, which suggested relapse of the lymphoma, although histopathological confirmation could not be realized.
authors.affiliation: Department of Hematology, Sapporo National Hospital.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Shirai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Mishina
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nakata
authors.forename: Keiko
authors.initials: K
authors.lastname: Aikawa
authors.forename: Kohki
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006338:Heart Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000628:therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000628:therapy*