Studies on the synthesis and Antithrombosis Activity of the Analogue of Fibrin Decomposed Product-Related Peptide.
HPA of 85.5% purity was synthesized by the solid phase method on HPLC. The data obtained from amino acid analysis and fast atom bombardment were in good agreement with the theoretical values. The studies on the biological activity demonstrated the peptide inhibited efficiently the in vitro ADP-induced human platelet aggregation. In vivo, the peptide increased evidently the activity of plasmin and inhibited experimental thrombosis in the rabbit.
Yang
Guo-Ling
GL
Department of Biology, Lanzhou University, Lanzhou 730000, China.
Li
Ke-Ging
KG
Hu
Xiao-Yu
XY