title: Clinical profile of leptospirosis in South gujarat.
abstract: BACKGROUND
  South Gujarat has been witnessing increasing incidence of leptospirosis for the last few years.
  
  
  OBJECTIVE
  To study the clinical profile of leptospirosis in South Gujarat.
  
  
  METHODS
  Prospective study during July-September 2000 at the New Civil Hospital, Surat, Gujarat.
  
  
  METHODS
  All the consecutive cases with clinical suspicion of leptospirosis were screened for lgM antileptospira antibody on the first and the fourteenth day. A four fold or greater increase in agglutinin antibody titre on paired samples was considered diagnostic. If the patient died before the fourteenth day then initial titre greater than 1:15 was considered diagnostic.
  
  
  RESULTS
  Total number of patients referred to the hospital were fifty, of which thirty-eight [33 males, with age 14-50 (30 +/- 10.51)] were diagnosed as having leptospirosis. Most common organs involved were liver (27, 71.05%) and kidney (24, 63.15%). Cardio-vascular (12, 31.5%), pulmonary (10, 26.35%), neurological (2, 5.26%) and haematological (8, 21%) involvements were less common. Six patients died because of pulmonary involvement in the form of alveolar haemorrhage, while one died because of cardiac involvement.
  
  
  CONCLUSIONS
  Liver and kidney were the most commonly involved organs in severe leptospirosis. Pulmonary involvement, though uncommon, led to high mortality.
authors.affiliation: Department of Medicine, Government Medical College, Surat - 395 001, Gujarat, India.
authors.forename: A M
authors.initials: AM
authors.lastname: Clerke
authors.forename: A C
authors.initials: AC
authors.lastname: Leuva
authors.forename: C
authors.initials: C
authors.lastname: Joshi
authors.forename: S V
authors.initials: SV
authors.lastname: Trivedi
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007922:Leptospirosis / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012424:Rural Population; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis; D014895:Weil Disease / Q000175:diagnosis / Q000453:epidemiology