title: [Comparative study on the efficacy of KLH-IDT and SEA-IDT in diagnosing schistosomiasis japonica].
abstract: Thirty-three egg-positive subjects and 32 egg-negative subjects were tested synchronously by KLH-IDT and SEA-IDT in endemic area of schistosomiasis. Compared with stool examination, the positive coincidence rate of KLH-IDT and SEA-IDT were 90% and 100%, respectively, which showed no statistical significance(P > 0.05), and the negative coincidence rate of KLH-IDT and SEA-IDT were 71.9% and 25%, respectively, which showed statistical significance(P < 0.01). Of the 31 egg-negative subjects, 9 subjects showed positive by both SEA-IDT and KLH-IDT, and 15 subjects showed positive by SEA-IDT but negative by KLH-IDT. Both double positive subjects and single positive subjects were examined further by miracidium hatching test, there were 2 subjects showing positive among the 9 double positive subjects. In addition, of 27 subjects that had been treated one year before, only 6 subjects showed positive by KLH-IDT, the reversion rate was 77.8%; whereas, the reversion rate was 22.2% (6/21) by SEA-IDT. The results suggest that KLH-IDT has high value in diagnosing schistosomiasis, particularly shows a potential in assessing therapeutic efficacy of schistosomiasis.
authors.affiliation: Department of Parasitology, Hunan Medical University, Changsha 410078.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Qin
authors.forename: X Y
authors.initials: XY
authors.lastname: Yi
authors.forename: Q R
authors.initials: QR
authors.lastname: Zeng
authors.forename: X F
authors.initials: XF
authors.lastname: Zeng
authors.forename: Z B
authors.initials: ZB
authors.lastname: Liu
authors.forename: S K
authors.initials: SK
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D003429:Cross Reactions; D006433:Hemocyanins / Q000276:immunology; D006801:Humans; D007428:Intradermal Tests / Q000379:methods; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D000947:Antigens, Helminth; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin