title: New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa.
abstract: A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.
authors.affiliation: School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Iwashima
authors.forename: Ikuo
authors.initials: I
authors.lastname: Terada
authors.forename: Kazuo
authors.initials: K
authors.lastname: Iguchi
authors.forename: Takao
authors.initials: T
authors.lastname: Yamori
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001156:Artemia; D002384:Catalysis; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D006865:Hydrogenation; D007564:Japan; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D013256:Steroids; D004875:Ergosterol