title: Interdependent effect of angiotensin-converting enzyme and platelet-activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy.
abstract: In order to investigate the interdependent action of the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene and polymorphism in exon 11 (C1136-->T; Ala379Val) of the platelet-activating factor acetylhydrolase (PAF-AH) gene, which encodes a functional antagonist of PAF, on the progression of immunoglobulin A (IgA) nephropathy, we analysed both polymorphisms in patients with primary IgA nephropathy, who were followed-up for longer than 3 years. During the follow-up (87.3 +/- 50.0 months), the disease progressed in 38 of the 191 patients (19.9%). The D allele of the ACE gene in the absence of the T allele of the PAF-AH gene did not affect the prognosis [odds ratio (OR), 3.6; 95% confidence interval (CI), 0.8-16.4] and neither did the T allele in the absence of the D allele (OR, 3.0; 95% CI, 0.4-24.2). However, the presence of both was a significant prognostic factor (OR, 6.6; 95% CI, 1.4-31.3). After adjusting for other risk factors, the presence of both proved to be an independent risk factor (OR, 4.5; 95% CI, 1.6-12.7). These results suggest that the interdependent effects of ACE and PAF-AH polymorphisms on the progression of IgA nephropathy might be more important than the effect of the individual polymorphisms.
authors.affiliation: Seoul Clinical Genomics Inc, Seoul, Korea, School of Public Health, Seoul National University, Seoul, Korea.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Yoon
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: H L
authors.initials: HL
authors.lastname: Kim
authors.forename: S G
authors.initials: SG
authors.lastname: Lee
authors.forename: S-H
authors.initials: SH
authors.lastname: Zheng
authors.forename: J H
authors.initials: JH
authors.lastname: Shin
authors.forename: C S
authors.initials: CS
authors.lastname: Lim
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000328:Adult; D005260:Female; D005787:Gene Frequency; D005922:Glomerulonephritis, IGA / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012044:Regression Analysis
chemical_list: D007070:Immunoglobulin A; D010741:Phospholipases A; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D007703:Peptidyl-Dipeptidase A