Neuromotor dysfunction in early psychosis.
Neuromotor dysfunction, particularly extrapyramidal signs and symptoms (EPSS), plays an important role in the assessment and treatment of patients in the early stages of psychotic disorders such as schizophrenia. By blocking dopamine D2 receptors, antipsychotic medications can produce EPSS, including tardive dyskinesia. EPSS is also observed in a third or more of patients first presenting with a psychotic disorder, prior to initiation of antipsychotic pharmacotherapy. This suggests that abnormalities in neuromotor control may be an integral component of the brain mechanisms associated with psychosis. Atypical antipsychotic agents can alleviate psychosis without inducing EPSS. Preexisting EPSS may be corrected.
Whitehorn
David
D
Nova Scotia Early Psychosis Program, Dartmouth, Canada. david.whitehorn@cdha.nshealth.ca
Kopala
Lili C
LC
D017109:Akathisia, Drug-Induced / Q000175:diagnosis / Q000209:etiology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001479:Basal Ganglia / Q000503:physiopathology; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000209:etiology; D020820:Dyskinesias / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D013577:Syndrome; D013997:Time Factors
D014150:Antipsychotic Agents