title: Enantioselective addition of diethylzinc to aldehydes catalyzed by optically active C2-symmetrical bis-beta-amino alcohols.
abstract: The syntheses of new optically active C(2)-symmetrical bis-beta-amino alcohols 1-6 from (S)-2-(1-hydroxy-1,1-diphenylmethyl)-pyrrolidine are described. Especially attention is focused on bridges, which link the two beta-amino alcohol units. These new chiral ligands have been successfully applied in the catalytic enantioselective addition of diethylzinc to aldehydes to give sec-alcohols in good yields with up to 95% enantiomeric excess.
authors.affiliation: Northwest Institute of Nuclear Technology, Xi'an, PR China. nintzhang@hz163.net
authors.forename: Qianyong
authors.initials: Q
authors.lastname: Xu
authors.forename: Guangming
authors.initials: G
authors.lastname: Zhu
authors.forename: Xinfu
authors.initials: X
authors.lastname: Pan
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan