title: Pseudocapillaria tomentosa, a nematode pathogen, and associated neoplasms of zebrafish (Danio rerio) kept in research colonies.
abstract: Infections with capillarid nematodes were observed in zebrafish (Danio rerio) kept at several research facilities and in a large carcinogen exposure study previously conducted at Oregon State University. We report a morphologic description that identifies the worm as Pseudocapillaria tomentosa, a common nematode of cyprinid and other fishes. Pathologic lesions associated with the infection ranged from inflammatory changes to aggressive neoplasms of the intestine (i.e., intestinal carcinomas and mixed malignant neoplasms). Capillarid nematodes may have intermediate or paratenic hosts. Using a laboratory transmission study, we confirmed that the parasite has a direct life cycle.
authors.affiliation: Center for Fish Disease Research, Department of Microbiology, Oregon State University, Corvallis 97331-3804, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kent
authors.forename: Janell K
authors.initials: JK
authors.lastname: Bishop-Stewart
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Matthews
authors.forename: Jan M
authors.initials: JM
authors.lastname: Spitsbergen
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D007414:Intestinal Neoplasms / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009348:Nematoda / Q000033:anatomy & histology / Q000502:physiology*; D009349:Nematode Infections / Q000473:pathology / Q000662:veterinary*; D015027:Zebrafish / Q000469:parasitology*