Interdependent effect of angiotensin-converting enzyme and platelet-activating factor acetylhydrolase gene polymorphisms on the progression of immunoglobulin A nephropathy.
In order to investigate the interdependent action of the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene and polymorphism in exon 11 (C1136-->T; Ala379Val) of the platelet-activating factor acetylhydrolase (PAF-AH) gene, which encodes a functional antagonist of PAF, on the progression of immunoglobulin A (IgA) nephropathy, we analysed both polymorphisms in patients with primary IgA nephropathy, who were followed-up for longer than 3 years. During the follow-up (87.3 +/- 50.0 months), the disease progressed in 38 of the 191 patients (19.9%). The D allele of the ACE gene in the absence of the T allele of the PAF-AH gene did not affect the prognosis [odds ratio (OR), 3.6; 95% confidence interval (CI), 0.8-16.4] and neither did the T allele in the absence of the D allele (OR, 3.0; 95% CI, 0.4-24.2). However, the presence of both was a significant prognostic factor (OR, 6.6; 95% CI, 1.4-31.3). After adjusting for other risk factors, the presence of both proved to be an independent risk factor (OR, 4.5; 95% CI, 1.6-12.7). These results suggest that the interdependent effects of ACE and PAF-AH polymorphisms on the progression of IgA nephropathy might be more important than the effect of the individual polymorphisms.
Yoon
H-J
HJ
Seoul Clinical Genomics Inc, Seoul, Korea, School of Public Health, Seoul National University, Seoul, Korea.
Kim
H
H
Kim
H L
HL
Lee
S G
SG
Zheng
S-H
SH
Shin
J H
JH
Lim
C S
CS
Kim
S
S
Lee
J S
JS
Lee
D S
DS
Kim
Y S
YS
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000328:Adult; D005260:Female; D005787:Gene Frequency; D005922:Glomerulonephritis, IGA / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012044:Regression Analysis
D007070:Immunoglobulin A; D010741:Phospholipases A; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D007703:Peptidyl-Dipeptidase A