title: The aging bladder--a significant but underestimated role in the development of lower urinary tract symptoms.
abstract: There are three major areas in which bladder dysfunction causes considerable losses in quality of life: detrusor instability, impaired detrusor function and detrusor reaction on bladder outlet obstruction. Considerable changes in detrusor morphology, detrusor innervation and bladder metabolism are seen with aging and obstruction. This causes dysfunction and lower urinary tract symptoms. The relation between aging per se and external influence on the detrusor from diseases in the nervous system, in the vascular supply and in the lower urinary tract itself is poorly understood. To improve our ability to prevent and treat these conditions we need more insight in these pathophysiological conditions.
authors.affiliation: Department of Urology, H110 Herlev Hospital, University of Copenhagen, DK2730 Herlev, Denmark. jnordling@dadlnet.dk
authors.forename: Jørgen
authors.initials: J
authors.lastname: Nordling
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D011469:Prostatic Diseases / Q000209:etiology*; D001743:Urinary Bladder / Q000294:innervation / Q000473:pathology / Q000502:physiology*; D001745:Urinary Bladder Diseases / Q000209:etiology*