A case of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber's disease) with dystrophic calcinosis cutis and retinal lesions.
A 65-year-old Japanese female developed a nodule on the distal interphalangealjoint of her right thumb. She also had multiple telangiectasias on her face, oral mucosa, tongue, nasal mucosa and upper extremities. A lip biopsy showed irregularly dilated capillaries and venules lined by flat endothelial cells. The nodule in the right thumb was resected. Histopathology revealed calcium deposits in the dermis. This case was diagnosed as dystrophic calcinosis cutis within hereditary hemorrhagic telangiectasia. Ophthalmologic examination showed bilateral retinal vascular lesions with dilated and tortuous retinal venules.
Takahama
Hideto
H
Division of Dermatology, Sagamihara-kyodo Hospital, Sagamihara-shi, Japan.
Noto
Shigemitsu
S
Ito
Masaru
M
Nishimoto
Hiroyuki
H
Tadokoro
Mamoru
M
D000368:Aged; D002114:Calcinosis / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D012164:Retinal Diseases / Q000150:complications* / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications*