[Effect of taixian tablet on hamster buccal pouch carcinogenesis].
Eighty syrian hamsters were divided into 4 equal groups. The right buccal pouches of hamsters in group I and group II were painted three times weekly with 0.5% DMBA dissolved in acetone, but the hamsters in group I received 0.45 g Taixian tablet daily by mouth. The animals in group III only received 0.45 g Taixian tablet daily and group IV was control group. After 9, 12 weeks, animals were killed with their pouches excised, and tumors were counted and measured. The results showed; 1. Comparing with group II, the malignant rate of group I was lower after 9 weeks and the tumor volume was smaller after 12 weeks (P < 0.01); 2. It was found histologically many inflammatory cells locating in the epithelial layer and lamina propria of group I after 9 weeks, while only a few inflammatory cells in group II. The high differentiated squamous cell carcinoma could be seen in group I and group II after 12 weeks, but no abnormal changes in cervical lymphnodes and organs (lung, liver, spleen, et al) of all animals in 4 groups. It suggests that Taixian tablet can restrain the development of oral carcinogenesis.
Duan
K
K
College of Stomatology, West China University of Medical Sciences.
Zheng
G
G
Li
B
B
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006224:Cricetinae; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007971:Leukoplakia / Q000150:complications / Q000473:pathology*; D008297:Male; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013607:Tablets
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D013607:Tablets; D015127:9,10-Dimethyl-1,2-benzanthracene