title: (+)-Tiliarine, a selective in vitro inhibitor of human melanoma cells.
abstract: Five diphenylbisbenzylisoquinoline (DBBI) alkaloids, tiliacorinine, tiliacorine, nor- tiliacorinine A, tiliarine and tiliamosine were isolated from the ethanol extract of the roots of Tiliacora racemosa Colebr. and identified by spectral techniques. Of these (+)-tiliarine is the only one which exhibited a selective inhibitory effect against human melanoma cells (G 361) and had no activity on normal human fibroblasts (CCD 974 SK). The activity of (+)-tiliarine against the human melanoma cell line was not much modified in the presence of calcium chloride.
authors.affiliation: Botanical Survey of India, Indian Botanic Garden, Shibpur, Howrah 711 103, India.
authors.forename: Tapan
authors.initials: T
authors.lastname: Seal
authors.forename: Biswapati
authors.initials: B
authors.lastname: Mukherjee
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D029583:Menispermaceae; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006576:Heterocyclic Compounds, 4 or More Rings; D010936:Plant Extracts; C468758:tiliarine; D002122:Calcium Chloride