title: Contribution of the interleukin-1beta gene polymorphism in multiple system atrophy.
abstract: We studied genetic polymorphisms in the promoter region at position -511 of the interleukin (IL) -1beta gene (IL-1B-511) and at position -889 of the IL-1alpha gene (IL-1A-889), in 111 Japanese patients with multiple system atrophy (MSA) and 160 controls. The distribution of IL-1B-511 was significantly different between MSA patients and controls, because of the under-representation of patients with homozygotes for allele 2 (IL-1B-511*2), a high producer of IL-1beta. The frequency of IL-1A-889*2, a high secretor of IL-1alpha, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA.
authors.affiliation: Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan. m_nishim@clin.med.tokushima-u.ac.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Nishimura
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Osamu
authors.initials: O
authors.lastname: Komure
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morino
authors.forename: Yuishin
authors.initials: Y
authors.lastname: Izumi
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nakamura
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
authors.forename: Sadako
authors.initials: S
authors.lastname: Kuno
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012016:Reference Values
chemical_list: D007375:Interleukin-1