Enantioselective Michael addition of beta-keto esters to methyl vinyl ketone employing a chiral N,N'-dioxide-scandium trifluoromethanesulfonate complex as a catalyst.
An enantioselective Michael addition of beta-keto esters to methyl vinyl ketone exploiting a chiral N,N'-dioxide-scandium trifluoromethanesulfonate complex as a catalyst affords the corresponding Michael adducts in high yields and with enantioselectivities of up to 80% ee.
Nakajima
M
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. nakajima@pharm.hokudai.ac.jp
Yamaguchi
Y
Y
Hashimoto
S
S