[Variation of blood lipids and circulatory endocrine factors in patients with acute myocardial infarction].
OBJECTIVE
To observe the dynamic variations of blood lipids and circulatory endocrine factors in acute myocardial infarction(AMI) patients.


METHODS
We determined plasma levels of ET-1, ANP, insulin and serum lipids on the 1st, 3rd, 7th and 14th day in 41 patients with acute myocardial infarction.


RESULTS
The serum levels of TC, LDL-C obviously decreased from the 3rd to the 7th day, and gradually elevated on the 14th day. The serum level of TG elevated gradually and showed significant difference after one week. HDL-C had no significant difference. The levels of ET-1 and insulin increased to highest level on the 1st day and decreased gradually since then. However, ANP reached the highest value on the 3rd day, and decreased markedly in fourteen days later. On the 1st day, only the concentration of insulin was negatively related with serum levels of TC, LDL-C(r = -0.376, -0.388, respectively, P < 0.05). The concentrations of blood lipids weren't related with circulatory endocrine factors during other phases.


CONCLUSIONS
The primary characteristics of blood lipids dynamic variations are the decrement of TC, LDL-C and the increment of TG during acute phase of AMI. Meanwhile, the concentrations of ET-1, ANP and insulin present dynamic variations and may effect the metabolism of blood lipids through some cytokines.
Li
Y F
YF
Department of Cardiology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Li
X P
XP
Zhao
S P
SP
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D019332:Endothelin-1; D007328:Insulin; D014280:Triglycerides; D009320:Atrial Natriuretic Factor