title: A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles.
abstract: Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation.
authors.affiliation: Department of Pharmaceutical Sciences, University of Florence, via Gino Capponi 9, 50121 Firenze, Italy.
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Bilia
authors.forename: M Camilla
authors.initials: MC
authors.lastname: Bergonzi
authors.forename: Francesco F
authors.initials: FF
authors.lastname: Vincieri
authors.forename: Pierandrea
authors.initials: P
authors.lastname: Lo Nostro
authors.forename: Gareth A
authors.initials: GA
authors.lastname: Morris
mesh_terms: D000465:Algorithms; D037621:Artemisinins / Q000737:chemistry*; D001205:Ascorbic Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004058:Diffusion; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D009502:Neutrons; D012542:Scattering, Radiation; D012717:Sesquiterpenes / Q000737:chemistry*; D012995:Solubility
chemical_list: D037621:Artemisinins; D008823:Micelles; D012717:Sesquiterpenes; C470083:octanoyl-6-O-ascorbic acid; C031327:artemisinin; D001205:Ascorbic Acid