Juvenile idiopathic arthritis genetics - what's new? What's next?
Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis (JIA). JIA is a complex genetic condition and the genes that influence susceptibility are actively being sought. A candidate gene approach is being used by several groups. MHC-, cytokine- and T-cell-related genes have all been positively associated with JIA. Here we review some of the latest genetic data, and discuss ways in which JIA genetic research might proceed.
Thomson
Wendy
W
Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, UK. wendy@fs1.ser.man.ac.uk
Donn
Rachelle
R
D001171:Arthritis, Juvenile / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D005838:Genotype; D014943:Global Health; D006801:Humans; D007391:International Cooperation; D017720:Molecular Epidemiology