title: [Mucormycosis. Report of 3 cases].
abstract: Mucormycosis is an acute and often fatal infection caused by a fungus of the Mucorales order of the Zygomycetes class. There are various clinical types, usually associated with an underlying disorder. The rhinocerebral mucormycosis is usually seen in diabetics, especially in ketoacidosis, but may also appear in healthy people. We report three cases of mucormycosis diagnosed since april 1987 through january 2001 at the Dr. Domingo Luciani Hospital, Caracas, Venezuela. Two of them had diabetes and one was apparently healthy. The most common clinical presentation of mucormycosis was the rhinocerebral infection, seen in the two diabetic patients, both of them had cavernous sinus thrombosis one with involvement of the carotid artery. The other patient with sinus involvement had no predisposing factors. All patients were treated with amphotericin B and two of them had surgical debridement of involved tissue. We emphasize the importance of an early clinical diagnosis and treatment with surgical debridement of infected tissue combined with amphotericin B.
authors.affiliation: Servicio de Medicina Interna, Hospital Dr. Domingo Luciani, Caracas, Venezuela. mjtristano@cantv.net
authors.forename: Antonio
authors.initials: A
authors.lastname: Tristano
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Chollet
authors.forename: María
authors.initials: M
authors.lastname: Willson
authors.forename: Marcos
authors.initials: M
authors.lastname: Troccoli
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D016893:Carotid Stenosis / Q000209:etiology; D020226:Cavernous Sinus Thrombosis / Q000209:etiology; D003131:Combined Modality Therapy; D003389:Cranial Nerve Diseases / Q000209:etiology; D048909:Diabetes Complications; D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D004803:Eosinophilic Granuloma / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D009669:Nose Neoplasms / Q000175:diagnosis; D010254:Paranasal Sinus Diseases / Q000150:complications / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D010291:Paresis / Q000209:etiology; D012189:Retrospective Studies; D014786:Vision Disorders / Q000209:etiology
chemical_list: D000935:Antifungal Agents