On the Molecular Mechanism of the Tumor Suppressor Function of cDNA Clone p14-6.
Interactions between the RNA transcript of the tumor suppressor cDNA clone, p14-6 (the 3'untranslated region of the nuclear factor for human interleukin-6; NF-IL6 3'UTR), and the reversion-related proteins BNF, were investigated. It was found that: (1) the recognition site of the RNA for BNFs was a 24-nucleotide segment located within the 3'-proximal U-rich sequence; (2) the BNFs were a group of proteins which may interact with each other before interacting with a site on the RNA as a protein complex; (3) possibly only one protein in the complex, namelyR62, directly bound to the RNA site.
Li
Zhao-Hui
ZH
Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China.
Liu
Ding-Gan
DG
Li
Zai-Ping
ZP