title: Sandhoff disease in a golden retriever dog.
abstract: A golden retriever dog is described with total hexosaminidase deficiency and raised GM2-ganglioside in CSF. The animal represents a model for human Sandhoff disease.
authors.affiliation: Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. osam@vetmed.hokudai.ac.jp
authors.forename: O
authors.initials: O
authors.lastname: Yamato
authors.forename: N
authors.initials: N
authors.lastname: Matsuki
authors.forename: H
authors.initials: H
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: K
authors.initials: K
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Maede
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology / Q000503:physiopathology; D012497:Sandhoff Disease / Q000235:genetics / Q000523:psychology / Q000662:veterinary*; D001619:beta-N-Acetylhexosaminidases / Q000134:cerebrospinal fluid / Q000172:deficiency
chemical_list: D001619:beta-N-Acetylhexosaminidases