title: [Research on inhibition of sodium fluoride on five subgingival bacteria in vitro].
abstract: This in vitro study was aimed at observing inhibition action of fluoride on 5 common periodontal bacteria in subgingival microflora. The liquid media two-fold dilution method was used to determine the minimal inhibition concentration (MIC) of sodium fluoride (NaF) to 9 strains of bacteria representing the main periodontopathic species(P. gingivalis, A. actinomycetemcomitans, P. intermedius) and the periodontal beneficial species (S. sanguis) and 1 strain of S. sorbrinus. The results showed that all the bacteria were inhibited at different concentration of NaF. The MIC values ranged from 128 micrograms/ml for P. gingivalis and A. actinomycetemcomitans, 256 micrograms/ml for S. sorbrinus, 1024 micrograms/ml for P. intermedius to 2048-4096 micrograms/ml for S. sanguis. The results suggest that NaF can also be used as a periodontal anti-bacterium agent and those preparations containing about 1000 micrograms/ml fluoride can be used effectively against the periodontopathic bacteria without disturbing the local ecological balance.
authors.affiliation: College of Stomatology, West China University of Medical Sciences.
authors.forename: W
authors.initials: W
authors.lastname: Qian
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Xiao
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology; D005881:Gingiva / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010518:Periodontitis / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000187:drug effects* / Q000302:isolation & purification; D012969:Sodium Fluoride / Q000494:pharmacology*; D013298:Streptococcus sanguis / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D012969:Sodium Fluoride