title: Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents.
abstract: N-Benzyl pyrrolidinyl sordaricin derivatives have been synthesized from cis-4-hydroxy-D-proline in a stereocontrolled manner. These compounds maintained moderate antifungal activity against several pathogenic fungal strains. Their MIC values against Candida albicans were in the range of 0.25-2 microg/mL.
authors.affiliation: Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 2-58, Hiromachi 1-chome, Shinagawa-ku, Tokyo, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Arai
authors.forename: Tamako
authors.initials: T
authors.lastname: Harasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuoka
authors.forename: Satoru
authors.initials: S
authors.lastname: Kaneko
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Konosu
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004224:Diterpenes; D015725:Fluconazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes; D007202:Indicators and Reagents; D011760:Pyrrolidinones; C116705:sordaricin; D015725:Fluconazole