title: Effects of vincristine treatment on semen quality in a dog with a transmissible venereal tumour.
abstract: The effect of vincristine treatment on semen parameters in a male boxer with a genital transmissible venereal tumour are described. The dog was treated with vincristine intravenously at 0.5 to 0.7 mg/m2 body surface area per week for six weeks until complete regression of the tumour occurred. Semen samples were collected before each application and then at weeks 10, 12, 17, 21 and 23 after the start of therapy. There were no alterations in libido or in testicular size and consistency either during or after treatment. Total sperm count decreased to abnormally low values during weeks 4 and 5, and then began to increase up to pretreatment values. No significant alterations in the other semen parameters were found during the study period.
authors.affiliation: Institute of Theriogenology, National University of La Plata, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Gobello
authors.forename: Y
authors.initials: Y
authors.lastname: Corrada
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D004285:Dogs; D007989:Libido / Q000187:drug effects; D008297:Male; D012661:Semen / Q000187:drug effects*; D014685:Venereal Tumors, Veterinary / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine