title: [Predictive value of changes in the hemostasis system in patients with ischemic brain diseases].
abstract: The aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D-dimer, PAI-1, antithrombin III, protein C and protein S, factor VII and factor VIII, fibrin degradation products, euglobulin test and th activated partial thromboplastin time--aPTPV) in relation to the level of the severity of ischaemic brain disorders (IBD) and the level of neurological and functional deficiency in the beginning of IBD manifestation from 7 to 10 days, 19 to 21 day, and after 3 to 6 months. The research results confirmed significant predictive value of changes of hemostatic system with the predomination of procoagulant factors, together with the insufficiency of fibrinolisys. Concerning the IBD severity and it's outcome, the significant predictive value was shown in the higher levels of PAI-1 and the lower level of antithrombin III, and borderline significant value was shown in the accelerated aggregation of thrombocytes and the increased concentration of D-dimer. It could be concluded that the tracking of the dynamics of changes in parameters of hemostatic system proved to be an easily accessible method with the significant predictive value regarding the development of more severe. IBD cases and the outcome of the disease itself.
authors.affiliation: Vojnomedicinska akademija, Klinika za neurologiju, Beograd.
authors.forename: Ranko
authors.initials: R
authors.lastname: Raicević
authors.forename: Aco
authors.initials: A
authors.lastname: Jovicić
authors.forename: Slavka
authors.initials: S
authors.lastname: Mandić-Radić
authors.forename: Dragana
authors.initials: D
authors.lastname: Dordević
authors.forename: Bratisłav
authors.initials: B
authors.lastname: Magdić
authors.forename: Ljubo
authors.initials: L
authors.lastname: Marković
authors.forename: Dragana
authors.initials: D
authors.lastname: Veljancić
authors.forename: Evica
authors.initials: E
authors.lastname: Dincić
authors.forename: Slobodan
authors.initials: S
authors.lastname: Obradović
mesh_terms: D001798:Blood Proteins / Q000032:analysis; D002545:Brain Ischemia / Q000097:blood*; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D010974:Platelet Aggregation; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D001798:Blood Proteins