Elevated chemokine responses are maintained in lungs after clearance of viral infection.
We observed two patterns of chemokine expression in the lungs of mice infected with murine gammaherpesvirus 68: peaks of chemokine expression correlated with or occurred after the peak of viral gene expression. Chemokine expression remained elevated through 29 days postinfection.
Weinberg
Jason B
JB
Department of Epidemiology, Division of Pediatric Infectious Diseases, University of Michigan, 109 Observatory Road, Ann Arbor, MI 48109, USA.
Lutzke
Mary L
ML
Efstathiou
Stacey
S
Kunkel
Steven L
SL
Rochford
Rosemary
R
D000818:Animals; D054413:Chemokine CCL11; D018932:Chemokine CCL2 / Q000235:genetics; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000235:genetics; D054357:Chemokine CXCL10; D054426:Chemokine CXCL2; D018925:Chemokines / Q000235:genetics*; D019742:Chemokines, CC / Q000235:genetics; D019743:Chemokines, CXC / Q000235:genetics; D006566:Herpesviridae Infections / Q000276:immunology* / Q000821:virology; D007700:Kinetics; D008168:Lung / Q000276:immunology* / Q000821:virology; D019402:Macrophage Inflammatory Proteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D018144:Rhadinovirus / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology* / Q000502:physiology
C515457:Ccl11 protein, mouse; D054413:Chemokine CCL11; D018932:Chemokine CCL2; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D054426:Chemokine CXCL2; D018925:Chemokines; D019742:Chemokines, CC; D019743:Chemokines, CXC; C404915:Cxcl2 protein, mouse; C118862:M3 protein, Murine gammaherpesvirus; D019402:Macrophage Inflammatory Proteins; D014764:Viral Proteins