Fixed-effect versus random-effect models for evaluating therapeutic preferences.
A preference trial is a special form of cross-over trial where clinical conditions determine when patients change treatment, in a prescribed order. This leads to binary responses with variable lengths. In cross-over trials with normal responses, patient effect may be treated as either fixed or random. However, with binary responses, random- and fixed-effect assumptions may lead to very different conclusions, so that one is no longer an alternative to the other.
Lee
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Department of Statistics, Seoul National University, Kwanakgu, Sinrimdong, Seoul, Korea.
D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods*; D018592:Cross-Over Studies; D006801:Humans; D015233:Models, Statistical
D001993:Bronchodilator Agents