title: The effect of the primary structure of the polypeptide catalyst on the enantioselectivity of the Juliá-Colonna asymmetric epoxidation of enones.
abstract: Epoxidation of chalcone (1), using basic hydrogen peroxide, catalysed by polypeptides with defined primary structures demonstrates that the residues in the chain near to the N-terminus determine the stereochemical outcome of the reaction.
authors.affiliation: Department of Chemistry, University of Liverpool, Liverpool, UK L69 7ZD.
authors.forename: P A
authors.initials: PA
authors.lastname: Bentley
authors.forename: R W
authors.initials: RW
authors.lastname: Flood
authors.forename: S M
authors.initials: SM
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Skidmore
authors.forename: C B
authors.initials: CB
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Smith
mesh_terms: D000595:Amino Acid Sequence; D002384:Catalysis; D002599:Chalcone / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D010455:Peptides; D002599:Chalcone; D006861:Hydrogen Peroxide