Chromosome positioning in the interphase nucleus.
Chromosomes occupy distinct territories in the interphase cell nucleus. These chromosome territories are non-randomly arranged within the nuclear space. We are only just uncovering how chromosome territories are organized, what determines their position and how their spatial organization affects the expression of genes and genomes. Here, we discuss emerging models of non-random nuclear chromosome organization and consider the functional implications of chromosome positioning for gene expression and genome stability.
Parada
Luis
L
National Cancer Inst., NIH, 20892, Bethesda, MD, USA.
Misteli
Tom
T
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D007399:Interphase / Q000502:physiology*; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D014178:Translocation, Genetic