title: Hepatitis e virus infection in fulminant hepatitis patients and an apparently healthy population in Bangladesh.
abstract: This is the first study comparing hepatitis E virus (HEV) infection in Bangladesh in fulminant hepatitis (FH) patients presumed to have a viral cause and in the apparently healthy population. Sera from 22 FH patients were analyzed for antibodies to hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C and D viruses, and HEV and for hepatitis B surface antigen (HBsAg). Anti-HEV immunoglobulin M (IgM) was detected in the sera of 63.6% of patients, whereas 35.7% were positive for HBsAg. A high prevalence of HEV infection (83.3%) was noted in the HBV carriers. Serum samples from 273 apparently healthy individuals were tested for antibodies to HAV and HEV. Anti-HEV IgM was detected in 7.3% of the samples. The seroprevalence of HAV differed from that of HEV in the same population because all samples were negative for anti-HAV IgM. These data indicate that HEV infection is highly endemic in Bangladesh.
authors.affiliation: Department of Pathology, Nihon University School of Medicine, Tokyo, Japan. sheikh@med.nihon-u.ac.jp
authors.forename: Aleemuzzaman
authors.initials: A
authors.lastname: Sheikh
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sugitani
authors.forename: Noriko
authors.initials: N
authors.lastname: Kinukawa
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Moriyama
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Komiyama
authors.forename: Tian-Cheng
authors.initials: TC
authors.lastname: Li
authors.forename: Naokazu
authors.initials: N
authors.lastname: Takeda
authors.forename: Shamsuddin M
authors.initials: SM
authors.lastname: Ishaque
authors.forename: Mahmud
authors.initials: M
authors.lastname: Hasan
authors.forename: Koyu
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001459:Bangladesh / Q000453:epidemiology; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000175:diagnosis / Q000453:epidemiology*; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral