title: [The electron probe microanalysis on oral precancer treated by garlic].
abstract: OBJECTIVE
  To evaluate the effect of 4 kinds of trace elements on experimental oral precancer treated by garlic.
  
  
  METHODS
  The palatal mucosae of 42 Wistar rats were painted with 0.5% of 4-nitroquinololine-1-oxide(4NQO) three times weekly for 7 weeks by coating method. Then the animals were divided randomly into two groups. The treatment group was treated three times weekly with garlic solution at the posterior hard palatal mucosae by coating method, and in the control group, the vehicle-distilled water was used instead of garlic solution. At the 5th and 8th weeks of the treatment and the 7th week after the treatment was stopped, some animals were killed. The palatal epithelial cells were prepared and surveyed by electron probe microanalysis.
  
  
  RESULTS
  During the treating period, garlic improved the levels of epithelial cells' nuclei copper, selenium, molybdenum and extranuclei selenium, molybdenum(P < 0.01), but it decreased the contents of epithelial cells' extranuclei copper and extra- and intranuclei zinc(P < 0.01).
  
  
  CONCLUSIONS
  Garlic can treat the oral precancer by improving the levels of epithelial cells' nuclei copper, selenium, and molybdenum and extranuclei selenium and molybdenum.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Tang
authors.forename: X P
authors.initials: XP
authors.lastname: Xu
authors.forename: Z H
authors.initials: ZH
authors.lastname: Shen
mesh_terms: D015112:4-Nitroquinoline-1-oxide; D000818:Animals; D003300:Copper / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004577:Electron Probe Microanalysis; D004847:Epithelial Cells / Q000473:pathology; D005737:Garlic; D008982:Molybdenum / Q000378:metabolism; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008517:Phytotherapy; D011230:Precancerous Conditions / Q000139:chemically induced / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D015112:4-Nitroquinoline-1-oxide; D003300:Copper; D008982:Molybdenum; D012643:Selenium