Emerging indications for MARS dialysis.
MARS stands for Molecular Adsorbent Recirculating System and represents an interesting option in treating patients with liver disease. There is still little known about the best time point of initiating this treatment and the exact selection criteria for patients who may benefit from this therapy. The list of potential applications using this procedure is expanding. We report on the experience in seven patients being treated with MARS dialysis for chronic cholestatic liver disease and acute on chronic liver failure. From August 2000 to October 2001 seven patients received 27 MARS treatments in our clinic, ranging from 2 to 12 treatments per subject. Presented cases were diagnosed as steatohepatitis because of alcoholism (n = 3), vanishing bile duct disease (n = 1), metabolic liver disease (n = 1), primary biliary cirrhosis (n = 1) and drug-induced hepatitis (n = 1). Based on this experience, we discuss the ongoing questions of various indications and the decision to initiate MARS dialysis.
Schachschal
G
G
Charité (CCM), Medzinische Klinik mit Schwerpunkt für Gastroenterologie und Hepatology, Medzinische Fakultät der Humboldt-Universität zu Berlin, Germany. schachschal@web.de
Morgera
S
S
Küpferling
S
S
Neumayer
H H
HH
Lochs
H
H
Schmidt
H H-J
HH
D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000628:therapy; D005235:Fatty Liver, Alcoholic / Q000628:therapy; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000628:therapy; D017114:Liver Failure, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D016060:Sorption Detoxification