title: Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.
abstract: OBJECTIVE
  Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE.
  
  
  METHODS
  In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured.
  
  
  RESULTS
  Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness.
  
  
  CONCLUSIONS
  The DMAE formulation under investigation increased skin firmness.
authors.affiliation: Unit of Dermocosmetology, Department of Dermatopathology, University Medical Center of Liège, CHU Sart Tilman, B-4000 Liège, Belgium.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Uhoda
authors.forename: Najat
authors.initials: N
authors.lastname: Faska
authors.forename: Caroline
authors.initials: C
authors.lastname: Robert
authors.forename: Geert
authors.initials: G
authors.lastname: Cauwenbergh
authors.forename: Gérald E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D000328:Adult; D016880:Anisotropy; D003642:Deanol / Q000494:pharmacology*; D003879:Dermatologic Agents / Q000494:pharmacology*; D003880:Dermatology / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D008875:Middle Aged; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D010865:Pilot Projects; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D013396:Suction; D013718:Tensile Strength
chemical_list: D003879:Dermatologic Agents; D005782:Gels; D014677:Pharmaceutical Vehicles; D003642:Deanol