Stimulated cortisol secretion is not correlated with prednisone dose or with steroid side-effects in children after renal transplantation.
Impairment of adrenocortical function and other adverse effects have to be considered whenever corticosteroids are applied for a prolonged period of time. We hypothesized that the assessment of adrenal function with adrenocortiocotropin (ACTH) stimulation reflects the sensitivity to corticosteroids and would predict the development of side-effects in pediatric patients on triple immunosuppression after renal transplantation.
Revermann
T
T
Departments of Pediatrics and Surgery, Philipps-University, Marburg, Germany.
Soergel
M
M
Hellinger
A
A
Klaus
G
G
D000293:Adolescent; D000309:Adrenal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone; D000328:Adult; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D012044:Regression Analysis; D018709:Statistics, Nonparametric
D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D011241:Prednisone; D006854:Hydrocortisone