title: A case of multiple Bowen's disease with squamous cell carcinoma of the larynx and adenocarcionoma of the prostate.
abstract: Bowen's disease, or cutaneous squamous cell carcinoma in situ, has been regarded as a cutaneous marker for internal malignancy. However, the relationship of Bowen's disease to visceral cancers remains controversial. We present a 76-year-old male with multiple lesions of Bowen's disease, who later developed laryngeal cancer and subsequent prostate cancer with distant metastases. Efforts to detect possible common etiologic agents including human papillomavirus and chronic arsenicism revealed no association between Bowen's disease and the internal malignancies. Despite the controversy, we suggest that a conservative cancer workup is ethically indicated in patients with multiple Bowen's disease.
authors.affiliation: Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Nark-Kyoung
authors.initials: NK
authors.lastname: Rho
authors.forename: Suk-Jin
authors.initials: SJ
authors.lastname: Choi
authors.forename: Eil-Soo
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma; D000368:Aged; D001913:Bowen's Disease / Q000473:pathology; D002294:Carcinoma, Squamous Cell; D006801:Humans; D007822:Laryngeal Neoplasms; D008297:Male; D009378:Neoplasms, Multiple Primary; D011471:Prostatic Neoplasms; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology