title: Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice.
abstract: To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.
authors.affiliation: Division of Life Science, Graduate School of Science and Technology, Kobe University, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nonaka
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Minato
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kawakami
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizuno
authors.forename: Itsuko
authors.initials: I
authors.lastname: Fukuda
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ashida
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000364:Agaricus / Q000737:chemistry*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D019363:Cytochrome P-450 CYP1A1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D007912:Lentinan / Q000494:pharmacology; D020074:Lentinula / Q000737:chemistry*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D011134:Polysaccharides; D007912:Lentinan; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D019363:Cytochrome P-450 CYP1A1