title: Effects of a high olive oil diet on the clinical behavior and histopathological features of rat DMBA-induced mammary tumors compared with a high corn oil diet.
abstract: Effects of a high virgin olive oil diet on the promotion stage of dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats were investigated in comparison with those of a high corn oil diet. Animals were randomly placed into 4 groups: control, fed a normolipidic control diet (3% corn oil); M, fed a high corn oil diet (20%); O, fed a high olive oil diet (3% corn oil plus 17% olive oil); and MO, fed the high olive oil diet after 33 days of high corn oil diet. Whereas the high corn oil diet clearly stimulated the mammary carcinogenesis, reducing the latency time and increasing the tumor incidence, multiplicity and volume, the high olive oil diet led to a lower tumor incidence than in the former group, a latency time similar to that of the control and lower tumor multiplicity and volume even than in the control group. Moreover, the histopathological features of the adenocarcinomas in olive oil groups were compatible with a greater degree of differentiation. These data suggest that the high virgin olive oil diet would have acted as a negative modulator of the experimental mammary carcinogenesis conferring to the tumors a more benign clinical behavior and a lower histopathological malignancy in comparison with the control and high corn oil diets.
authors.affiliation: Department of Cell Biology, Physiology and Immunology, Medical Physiology Unit, Medical School, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Solanas
authors.forename: Antoni
authors.initials: A
authors.lastname: Hurtado
authors.forename: Irmgard
authors.initials: I
authors.lastname: Costa
authors.forename: Raquel
authors.initials: R
authors.lastname: Moral
authors.forename: Javier Abel
authors.initials: JA
authors.lastname: Menéndez
authors.forename: Ramon
authors.initials: R
authors.lastname: Colomer
authors.forename: Eduard
authors.initials: E
authors.lastname: Escrich
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D003314:Corn Oil / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced* / Q000188:drug therapy*; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D002273:Carcinogens; D005227:Fatty Acids; D000069463:Olive Oil; D010938:Plant Oils; D015127:9,10-Dimethyl-1,2-benzanthracene; D003314:Corn Oil