title: Gonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosus.
abstract: OBJECTIVE
  To evaluate gonadal function in male adolescents and young men with juvenile onset systemic lupus erythematosus (SLE).
  
  
  METHODS
  Four young men with SLE underwent clinical and laboratory evaluation, testicular ultrasound, follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, and anti-sperm antibody determination. The semen analyses were performed according to the WHO guidelines and Kruger strict criteria. All patients were asked to provide 3 semen samples over a period of 2 months. A new sample was collected 6 months later.
  
  
  RESULTS
  The median disease duration was 6.6 years. The median age at initial ejaculation was 13.5 years. All 4 patients had severe disease with renal involvement (WHO class IV or V). The SLICC/ACR damage index at the time of study entry ranged between 0 and 3. The patients' Tanner stage was P5G5; all reported normal erection and libido. Gonadal evaluation by thorough examination of the genitalia and ultrasound was normal. Anti-sperm antibodies were negative in all patients. Only one patient showed high FSH and LH levels. The initial and final semen evaluations of the 4 patients were abnormal (azoospermia, oligoastenoteratospermia, or teratospermia). One patient was receiving azathioprine and 2 were receiving cyclophosphamide at the time of study entry.
  
  
  CONCLUSIONS
  Although these patients had normal sexual activity and normal external genitalia, their fertility was decreased based on the sperm abnormalities. Serial semen analyses in larger study populations will be necessary to clarify the degree and duration of sperm abnormalities in male patients with SLE in general.
authors.affiliation: Department of Pediatrics, Children's Institute, University of São Paulo, SP, Brazil. clovisaas@icr.hcnet.usp.br
authors.forename: Clovis A A
authors.initials: CA
authors.lastname: Silva
authors.forename: Jorge
authors.initials: J
authors.lastname: Hallak
authors.forename: Fabio F
authors.initials: FF
authors.lastname: Pasqualotto
authors.forename: Mário F
authors.initials: MF
authors.lastname: Barba
authors.forename: Maria I
authors.initials: MI
authors.lastname: Saito
authors.forename: Maria H B
authors.initials: MH
authors.lastname: Kiss
mesh_terms: D000293:Adolescent; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000032:analysis; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000209:etiology; D007248:Infertility, Male / Q000175:diagnosis / Q000209:etiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D007986:Luteinizing Hormone / Q000032:analysis; D008297:Male; D009845:Oligospermia / Q000175:diagnosis / Q000209:etiology*; D011379:Prognosis; D018570:Risk Assessment; D012494:Sampling Studies; D012661:Semen / Q000166:cytology*; D013076:Sperm Count; D013081:Sperm Motility; D013739:Testosterone / Q000032:analysis
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone