title: Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes.
abstract: Two conformationally restricted analogues of (-)-indolactam-V (1) (cis and trans amides) were examined for their binding selectivity to the synthetic C1 peptides of all protein kinase C (PKC) isozymes. Although the binding constants of the cis amide-restricted analogue (2) were equal to those of 1, the trans amide-restricted analogue (3) bound significantly only to the novel PKC (delta, epsilon, eta, theta) isozymes.
authors.affiliation: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Masuda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Irie
authors.forename: Yu
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Ohigashi
mesh_terms: D007211:Indoles / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D007769:Lactams / Q000378:metabolism*; D011487:Protein Conformation; D011493:Protein Kinase C / Q000378:metabolism*
chemical_list: D007211:Indoles; D007527:Isoenzymes; D007769:Lactams; C043969:indolactam V; D011493:Protein Kinase C