title: [Optic coherent tomography: a new high-resolution technology of visualization of tissue structures. Part 1. Principle of the technique. Objects of OCT applications and technical decisions for their study].
abstract: The authors present a series of three papers dedicated to studies made in Russia in the field of optic coherent tomography (OCT), the latest noninvasive high-resolution technology of visualization of the structure of biological tissues. A group of medical specialists of different disciplines has been examined over 2,000 patients for 8 years of the use of an original class of the Russian OCT devices developed at the Institute of Applied Physics, Russian Academy of Sciences, and awarded a RF State Prize in the field of science and technology in 1999. The first paper discusses the basic aspects of OCT, the objects of study, and technical decisions for the clinical application of the technique. The paper shows a place of OCT, whose resolving capacity is close to the cellular level (approximately 10-15 microns), among classical methods for imaging biological tissues. The optical images of different types of normal tissues and the method of their identification are demonstrated. It has been found that different optical properties of investing tissues and dentin permit their tomographic differentiation by showing their regular bedded structure. The tomographic pattern of investing tissues is affected by their specific features, such as the type of the lining epithelium, its keratosic processes, and the architecture of the basilar membrane.
authors.affiliation: Nizhni Novgorod Medical Academy, Institute of Applied Physics, Russian Academy of Sciences, Semashko Nizhni Novgorod Regional Clinical Hospital, Nizhni Novgorod.
authors.forename: N D
authors.initials: ND
authors.lastname: Gladkova
authors.forename: N M
authors.initials: NM
authors.lastname: Shakhova
authors.forename: B E
authors.initials: BE
authors.lastname: Shakhov
authors.forename: G V
authors.initials: GV
authors.lastname: Gelikonov
mesh_terms: D004848:Epithelium / Q000000981:diagnostic imaging; D004947:Esophagus / Q000033:anatomy & histology / Q000166:cytology / Q000000981:diagnostic imaging; D006801:Humans; D007830:Larynx / Q000033:anatomy & histology / Q000166:cytology / Q000000981:diagnostic imaging; D036103:Nanotechnology; D055095:Optics and Photonics; D011859:Radiography; D014054:Tomography / Q000295:instrumentation* / Q000379:methods*; D014070:Tooth / Q000166:cytology / Q000000981:diagnostic imaging; D001743:Urinary Bladder / Q000033:anatomy & histology / Q000166:cytology / Q000000981:diagnostic imaging