Probiotics and intestinal health effects: a clinical perspective.
Probiotics are viable non-pathogenic micro-organisms which, when ingested, exert a positive influence on host health or physiology. We have critically analysed the evidence for the efficacy of specific probiotic strains in human gastrointestinal diseases. The best evidence can be obtained with randomised controlled trials which avoid bias. Good evidence has been obtained with several strains in the prevention or treatment of antibiotic-associated disorders, in the treatment (and to a lesser extent prevention) of gastroenteritis and acute diarrhoea and in the alleviation of lactose intolerance. We also analysed the recent randomised controlled trials performed in patients with Clostridium difficile or Helicobacter pylori, inflammatory bowel disease, irritable bowel syndrome, non-ulcer dyspepsia and colon cancer.
Marteau
P
P
Gastroenterology Department, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, 20 rue Leblanc, 75908 CEDEX 15, France. philippe.matteau@egp.ap-hop-paris.fr
Seksik
P
P
Jian
R
R
D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003967:Diarrhea / Q000139:chemically induced / Q000178:diet therapy; D005759:Gastroenteritis / Q000178:diet therapy; D005767:Gastrointestinal Diseases / Q000178:diet therapy*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000178:diet therapy; D019936:Probiotics / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents