title: Long term results of radiosurgery for vestibular schwannomas.
abstract: Radiosurgery is either a primary or an adjunct management approach used to treat patients with vestibular schwannomas. The goals are long-term tumour growth control, maintenance of cranial nerve function and prevention of new neurologic deficiencies. We sought to determine long-term outcomes measuring the potential benefits against the neurological risks of radiosurgery.
  
  
  METHODS
  278 patients with vestibular schwannomas underwent Gamma Knife radiosurgery as a treatment modality for from April 1992 to November 2001. The long-term results of 60 patients were evaluated who received radiosurgery as primary treatment. 12 cases presented with previously performed subtotal microsurgical resection or recurrence of disease (12-96 months, median 39). The median treatment volume was 3.8 ccm and the median dose to the tumour margin was 12 Gy. The median patient follow-up time was 88 months (range 72-114 months).
  
  
  RESULTS
  Four tumours progressed after primary radiosurgery. Tumour control rate was 93%. Useful hearing (Gardner-Robertson I/II) was preserved in 16 patients (55%). Clinical neurological improvement occurred in 36 patients (60%). Adverse effects comprised neurological symptoms (incomplete facial palsy) (House-Brackman II/III) in five cases (three recovered completely), mild trigeminal neuropathy in three cases, and morphological changes displaying rapid enlargement of preexisting macrocysts in two patients and tumour growth in two other ones. Microsurgical resection was performed in three cases (5%) and one patient underwent a shunting procedure because of hydrocephalus formation. In patients who had undergone previous microsurgery, neither new cranial nerve deficit nor any tumour growth was observed.
  
  
  CONCLUSIONS
  Radiosurgery performed with current techniques proved to be an effective method for growth control of vestibular schwannomas with both a low mortality rate and a good quality of life. An increasing percentage of patients will undergo radiosurgery as accessibility to this alternative increases, and more data regarding long-term follow-up are available. It is a post-operative complementary treatment for partially removed tumours. Accordingly, radiosurgery is a useful method for the management of properly selected patients.
authors.affiliation: Department of Neurosurgery, Karl-Franzens University, Graz, Austria. frank.unger@klinikum-graz.at
authors.forename: F
authors.initials: F
authors.lastname: Unger
authors.forename: C
authors.initials: C
authors.lastname: Walch
authors.forename: G
authors.initials: G
authors.lastname: Papaefthymiou
authors.forename: S
authors.initials: S
authors.lastname: Eustacchio
authors.forename: K
authors.initials: K
authors.lastname: Feichtinger
authors.forename: F
authors.initials: F
authors.lastname: Quehenberger
authors.forename: G
authors.initials: G
authors.lastname: Pendl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D005155:Facial Nerve Diseases / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D034381:Hearing Loss / Q000209:etiology; D006320:Hearing Tests; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000473:pathology / Q000601:surgery*; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D011183:Postoperative Complications / Q000503:physiopathology; D016634:Radiosurgery / Q000009:adverse effects; D012189:Retrospective Studies; D014012:Tinnitus / Q000209:etiology; D014277:Trigeminal Neuralgia / Q000209:etiology; D014722:Vestibule, Labyrinth / Q000473:pathology