Cytometric evaluation of peripheral blood lymphocytes in dogs with lymphoma during chemotherapy.
Twenty dogs with clinically diagnosed multicentric lymphoma were evaluated for percentages of peripheral blood lymphocyte subpopulations. Cytometric analysis was performed before and during chemotherapy. The results were compared to those obtained from a control group of healthy dogs. The percentages of CD5+, CD4+ and CD8+ cells were markedly decreased and CD21-like+ cells markedly increased in dogs with lymphoma in comparison with the control group. During the course of chemotherapy these values returned to ranges observed in healthy animals.
Winnicka
A
A
Department of Internal Diseases, Faculty of Veterinary Medicine, Warsaw, Poland. winnicka@amaltea.sggw.waw.pl
Jagielski
D
D
Hoffmann-Jagielska
M
M
Lechowski
R
R
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016022:Case-Control Studies; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D004285:Dogs; D005260:Female; D005434:Flow Cytometry / Q000662:veterinary; D016130:Immunophenotyping / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*; D008223:Lymphoma / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone