Cell proliferation and DNA fragmentation (apoptosis) on FNABs of breast invasive ductal carcinomas and their relationship to clinicopathological variables and prognosis.
The purpose of this study was to investigate cell proliferation and apoptosis in ductal breast invasive carcinomas and their relationship to prognosis. Fifty cases, from the same number of operable female patients, were diagnosed cytologically on FNA biopsies as invasive ductal breast carcinomas and confirmed histologically after oncectomy. In the same cases, to evaluate the cell proliferation and apoptosis, the MIB1 and the TUNEL method were used respectively. Furthermore the relationship between proliferative activity and apoptosis to other factors such as menopausal status, tumor size, axillary lymph node status and tumor grade was studied. Cell proliferation and apoptosis were found to be significantly related to the menopausal status of the patients (p < 0.001) and to the grade of the tumor (p < 0.01), while no significant relationship to axillary lymph node status and tumor size was found.
Kalogeraki
A M
AM
Department of Surgical Oncology and Pathology-Cytopathology, Medical School University of Crete, Greece.
Antoniou
Ch G
ChG
Askoxylakis
J P
JP
Darivianaki
B M
BM
Stathopoulos
E N
EN
Delides
G S
GS
Tsiftsis
D D
DD
D000328:Adult; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D002455:Cell Division; D053938:DNA Fragmentation; D005260:Female; D006801:Humans; D020287:In Situ Nick-End Labeling; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis