Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide.
A series of pharmaceutically active compounds including diclofenac, gemfibrozil, ibuprofen, naproxen, 2-propylpentanoic acid, 4-biphenylacetic acid and tolfenamic acid can be reversibly intercalated into a layered double hydroxide, initial studies suggest that these materials may have application as the basis of a novel tuneable drug delivery system.
Khan
A I
AI
Inorganic Chemistry Laboratory, South Parks Road, Oxford, UK OX1 3QR.
Lei
L
L
Norquist
A J
AJ
O'Hare
D
D
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004008:Diclofenac / Q000493:pharmacokinetics; D015248:Gemfibrozil / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000737:chemistry*; D007052:Ibuprofen / Q000493:pharmacokinetics; D009288:Naproxen / Q000493:pharmacokinetics; D010648:Phenylacetates / Q000493:pharmacokinetics; D014635:Valproic Acid / Q000493:pharmacokinetics; D062367:ortho-Aminobenzoates / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D006878:Hydroxides; D010648:Phenylacetates; D062367:ortho-Aminobenzoates; D004008:Diclofenac; C009500:tolfenamic acid; C012776:biphenylylacetic acid; D009288:Naproxen; D014635:Valproic Acid; D015248:Gemfibrozil; D007052:Ibuprofen