title: [Effects of complexes of alpha-fetoprotein and amphiphilic docosaenoic acid derivatives on the humoral immune response in C57BL/6 mice].
abstract: The immunotropic activity of three derivatives of docosahexaenic acid (N-docosahexaenoyl-L-serine phosphate, N-docosahexaenoyl-L-threonine phosphate, and N-docosahexaenoyl-L-tyrosine phosphate) in complexes with high-purity human alpha-fetoprotein was evaluated. The polyene compounds stimulate the humoral immunity in mice immunized with T-dependent antigen (ram red blood cells). The immunotropic activity of the alpha-fetoprotein-ligand complexes studied depends on the structure and the content of polyene ligands.
authors.affiliation: Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, ul. Akademika Kuprevicha 5/2, Minsk, 220141 Belarus.
authors.forename: D V
authors.initials: DV
authors.lastname: Arsenov
authors.forename: M B
authors.initials: MB
authors.lastname: Golubeva
authors.forename: M A
authors.initials: MA
authors.lastname: Kisel'
authors.forename: N A
authors.initials: NA
authors.lastname: Konoplia
authors.forename: B B
authors.initials: BB
authors.lastname: Kuz'mitskiĭ
authors.forename: G S
authors.initials: GS
authors.lastname: Liubin
authors.forename: O A
authors.initials: OA
authors.lastname: Strel'chenok
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004281:Docosahexaenoic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D051379:Mice; D008810:Mice, Inbred C57BL; D012694:Serine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013912:Threonine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D000509:alpha-Fetoproteins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D008024:Ligands; C465402:N-docosahexaenoylserine phosphate; C465400:N-docosahexaenoylthreonine phosphate; C465401:N-docosahexaenoyltyrosine phosphate; D000509:alpha-Fetoproteins; D004281:Docosahexaenoic Acids; D013912:Threonine; D014443:Tyrosine; D012694:Serine