title: Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies.
abstract: OBJECTIVE
  To assess the outcome of intensive care unit (ICU) treatment in patients with hematological malignancies.
  
  
  METHODS
  Retrospective cohort study in the medical ICU of a university hospital.
  
  
  METHODS
  104 critically ill patients after receiving conventional chemotherapy or autologous hematopoietic stem cell transplantation.
  
  
  METHODS
  We analyzed demographic data, underlying disease, intensity of antineoplastic regimen, cause of admission, need for mechanical ventilation, and hemofiltration, ICU survival, and survival after discharge, furthermore neutrophil count, C-reactive protein (<or=150 vs. >150 mg/l), antithrombin III, prothrombin time, and SAPS II (<or=50 vs. >50) at ICU admission. All recorded variables were evaluated for prognostic relevance by univariate and multivariate analyses.
  
  
  RESULTS
  Overall ICU mortality was 44%, with significantly higher mortality in ventilated patients (74% vs. 12% in nonventilated patients, p<0.001). Overall survival for the entire group 6 months and 1 year after ICU admission was 33% and 29%, respectively. Multivariate analysis revealed mechanical ventilation and SAPS II as independent prognostic factors of both ICU mortality and long-term survival, while C-reactive protein predicted only ICU mortality.
  
  
  CONCLUSIONS
  The outcome of patients not requiring ventilatory support in this study was encouraging, while invasive ventilation was again confirmed as predicting a dismal prognosis in this population. Efforts should be directed to avoiding this procedure by reducing the pulmonary toxicity of antineoplastic treatment and to making ventilatory support more tolerable.
authors.affiliation: Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Technische Universität, Fetscherstrasse 74, 01307 Dresden, Germany. kroschinsky@mk1.med.tu-dresden.de
authors.forename: Frank
authors.initials: F
authors.lastname: Kroschinsky
authors.forename: Matthias
authors.initials: M
authors.lastname: Weise
authors.forename: Thomas
authors.initials: T
authors.lastname: Illmer
authors.forename: Mathias
authors.initials: M
authors.lastname: Haenel
authors.forename: Martin
authors.initials: M
authors.lastname: Bornhaeuser
authors.forename: Gert
authors.initials: G
authors.lastname: Hoeffken
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ehninger
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schuler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005858:Germany; D019337:Hematologic Neoplasms / Q000145:classification / Q000628:therapy*; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends*; D016896:Treatment Outcome