Linkage of chromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sample.
Several prior reports have suggested that chromosomal region 13q32 may harbor a schizophrenia susceptibility gene. In an attempt to replicate this finding, we assessed linkage between chromosome 13 markers and schizophrenia in 166 families, each with two or more affected members. The families, assembled from multiple centers by the Department of Veterans Affairs Cooperative Studies Program, included 392 sampled affected subjects and 216 affected sib pairs. By DSM-III-R criteria, 360 subjects (91.8%) had a diagnosis of schizophrenia and 32 (8.2%) were classified as schizoaffective disorder, depressed. The families had mixed ethnic backgrounds. The majority were northern European-American families (n = 62, 37%), but a substantial proportion were African-American kindreds (n = 60, 36%). Chromosome 13 markers, spaced at intervals of approximately 10 cM over the entire chromosome and 2-5 cM for the 13q32 region were genotyped and the data analyzed using semi-parametric affected only linkage analysis. For the combined sample (with race broadly defined and schizophrenia narrowly defined) the maximum LOD score was 1.43 (Z-score of 2.57; P = 0.01) at 79.0 cM between markers D13S1241 (76.3 cM) and D13S159 (79.5 cM). Both ethnic groups showed a peak in this region. The peak is within 3 cM of the peak reported by Brzustowicz et al. [1999: Am J Hum Genet 65:1096-1103].
Faraone
Stephen V
SV
Brockton/West Roxbury Veterans Affairs Medical Center, Brockton, Massachusetts, USA. sfaraone@hms.harvard.edu
Skol
Andrew D
AD
Tsuang
Debby W
DW
Bingham
Stephen
S
Young
Keith A
KA
Prabhudesai
Sarita
S
Haverstock
Susan L
SL
Mena
Felicitas
F
Menon
Aerath Sri Kumar
AS
Bisset
Darren
D
Pepple
John
J
Sautter
Fred
F
Baldwin
Charlene
C
Weiss
David
D
Collins
Joseph
J
Keith
Tim
T
Boehnke
Michael
M
Tsuang
Ming T
MT
Schellenberg
G D
GD
D000328:Adult; D001741:Black or African American; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D012559:Schizophrenia / Q000235:genetics*; D014481:United States; D014493:United States Department of Veterans Affairs
D004247:DNA