Genetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment.
Clozapine treatment frequently causes body weight gain that may impair health and may affect patient compliance. While the histamine-1 (H1) receptor may play a major role in the mechanism of the clozapine-induced body weight change, we tested the relationship between the genetic variant (Glu349Asp) of the H1 receptor and the clozapine-induced body weight change. Eighty-eight schizophrenic patients treated with clozapine were included in this study. Analysis of body weight change after 4 months of clozapine treatment showed no relationship with the H1 genotype. Further exploration of the other H1 genotypes and the antipsychotic-induced body weight change may help in the understanding of the mechanisms of antipsychotic-induced body weight gain and in the choice of patient's antipsychotic regimens.
Hong
Chen-Jee
CJ
Department of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan. cjhong@vghtpe.go.tw
Lin
Ching-Hua
CH
Yu
Younger W-Y
YW
Chang
Su-Chen
SC
Wang
Shu-Ying
SY
Tsai
Shih-Jen
SJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D001835:Body Weight / Q000187:drug effects*; D003024:Clozapine / Q000627:therapeutic use*; D017931:DNA Primers; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011969:Receptors, Histamine H1 / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy*; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D017931:DNA Primers; D011969:Receptors, Histamine H1; D012702:Serotonin Antagonists; D003024:Clozapine