Restraint stress impaired maternal behavior in female mice lacking the neuromedin B receptor (NMB-R) gene.
Neuromedin B (NMB) is a bombesin-like peptide that exerts its function via NMB receptor (NMB-R). The NMB/NMB-R pathway is involved in the regulation of a wide variety of behaviors, such as spontaneous activity, feeding, and anxiety-related behavior. In the current study, we assessed the effects of stress on maternal behavior in female NMB-R-deficient mice. Non-stressed NMB-R-deficient and wild-type mice showed normal maternal behavior. However, immediately after undergoing restraint-induced stress (30 min) both genotypes of mice exhibited severely decreased maternal behaviors. Furthermore, 30 min after stress induction, maternal behavior in wild-type mice recovered to near normal levels whereas that of NMB-R-deficient mice remained significantly lower. These results indicate that NMB-R-deficient mice suffer more severely from stress and suggest that dysfunction in the NMB/NMB-R pathway may constitute one of the risk factors of stress vulnerability.
Yamada
Kazuyuki
K
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira-City, Tokyo 187-8502, Japan. kaz-yamada@brain.riken.go.jp
Santo-Yamada
Yuko
Y
Wada
Keiji
K
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D016009:Chi-Square Distribution; D005260:Female; D008425:Maternal Behavior / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018004:Receptors, Bombesin / Q000235:genetics / Q000502:physiology*; D012149:Restraint, Physical; D018570:Risk Assessment; D018709:Statistics, Nonparametric
D018004:Receptors, Bombesin