Further halotyrosine derivatives from the marine sponge Suberea aff. praetensa.
Reexamination of the marine sponge Suberea aff. praetensa, (Row) from the Gulf of Thailand furnished in addition to bromotyrosine derivatives found previously 5-bromo- and 5-chlorocavernicolin, cavernicolins 1 and 2, two other brominated tyrosine metabolites, a known bisoxazolidone and a new unusual rearranged tyrosine metabolite subereatensin. Several of the metabolites exhibited significant inhibitory effects against five human cancer cell lines.
Kijjoa
Anake
A
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Portugal.
Watanadilok
Rawiwan
R
Sonchaeng
Pichai
P
Sawangwong
Pichan
P
Pedro
Madalena
M
Nascimento
Maria São José
MS
Silva
Artur M S
AM
Eaton
Graham
G
Herz
Werner
W
D000818:Animals; D001943:Breast Neoplasms; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry* / Q000254:growth & development; D013785:Thailand; D014020:Tissue Extracts / Q000737:chemistry / Q000302:isolation & purification; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology
D014020:Tissue Extracts; D014443:Tyrosine