title: WASp in immune-system organization and function.
abstract: The regulation of many immunological events depends on systems that mediate dynamic actin reorganization in response to signals from the cell membrane. The Wiskott-Aldrich syndrome protein (WASp) is the founding member of a family of proteins that have emerged as crucial effectors of Rho GTPases and activators of the cytoskeletal-organizing complex Arp2/3. Now, WASp has been shown to be intimately involved in many pathways that influence the function of the immune system. Disturbances in these systems result in the complex immunodysregulation of Wiskott-Aldrich syndrome.
authors.affiliation: Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. a.thrasher@ich.ucl.ac.uk
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Thrasher
mesh_terms: D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000378:metabolism; D000818:Animals; D001773:Blood Cells / Q000502:physiology; D002462:Cell Membrane / Q000276:immunology; D003598:Cytoskeletal Proteins / Q000096:biosynthesis; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008840:Microfilament Proteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000276:immunology / Q000502:physiology; D010587:Phagocytosis; D011506:Proteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction; D014923:Wiskott-Aldrich Syndrome / Q000097:blood / Q000276:immunology* / Q000628:therapy; D051316:Wiskott-Aldrich Syndrome Protein; D051300:Wiskott-Aldrich Syndrome Protein Family; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; D020741:rho GTP-Binding Proteins / Q000096:biosynthesis
chemical_list: C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D003598:Cytoskeletal Proteins; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D011506:Proteins; C495767:WAS protein, human; C495771:WASL protein, human; D051316:Wiskott-Aldrich Syndrome Protein; D051300:Wiskott-Aldrich Syndrome Protein Family; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; D020741:rho GTP-Binding Proteins