From counting neurons to the preclinical diagnosis of Alzheimer's disease.
This article is a review of scientific work on Alzheimer neurofibrillary degeneration and Ass-amyloidosis that was done in collaboration with Dr. Henryk Wisniewski, in part at the Institute for Basic Research in Developmental Disabilities. Our work on paired helical filaments and the tau protein spans from basic immunocytochemical analyses of brain tissue to clinical application as a biological marker used in diagnostic tests. Even though only a small part of Dr. Wisniewski's scientific oeuvre, these data illustrate how a great scientist opens the field to his student, collaborator and friend, how basic science can evolve, and how results can be applied in clinical practice to the benefit of our patients.
Bancher
Christian
C
Ludwig Boltzmann Institute of Clinical Neurobiology, Vienna, Austria. Department of Neurology, Waldviertelklinikum Horn, Austria.