title: [Utility of pravastin in cardiac transplant dyslipidemia].
abstract: Patients undergoing cardiac transplantation are at increased risk of dyslipidemia (60% to 80%). Lipid-lowering treatment in these patients should be aggressive given the known role of dyslipidemia in chronic transplant rejection. The objective of this study was to evaluate the efficacy and safety of pravastatina therapy and its effect upon cyclosporine levels in a population of dyslipidemic cardiac transplant patients.A total of 20 cardiac transplant patients were enrolled in this 39-week length prospective observational study. Patients had serum cholesterol levels exceeding 200 mg/dl, and received pravastatin therapy at the adequate dose to obtain an optimal lipid profile without significant adverse effects. Pravastatin, at a mean dose of 50 18 mg/day, produced a significant reduction in total cholesterol levels (from 291 32 to 203 25 mg/dl, p < 0.05), LDL cholesterol (from 187 34 to 102 15 mg/dl, p < 0.05) and an increase in HDL-cholesterol levels (from 48 16 to 55 14, p < 0.05). A slight asymptomatic increase in CPK levels was observed but no differences in cyclosporine levels. Pravastatin has shown to be an effective and safe therapy in dyslipidemic cardiac transplant patients.
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Fe, Valencia, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Martínez-Dolz
authors.forename: L
authors.initials: L
authors.lastname: Almenar Bonet
authors.forename: M A
authors.initials: MA
authors.lastname: Arnau Vives
authors.forename: J
authors.initials: J
authors.lastname: Rueda Soriano
authors.forename: A
authors.initials: A
authors.lastname: Osa Sáez
authors.forename: F
authors.initials: F
authors.lastname: Dicenta Gisbert
authors.forename: M
authors.initials: M
authors.lastname: Palencia Pérez
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000097:blood / Q000627:therapeutic use; D016027:Heart Transplantation; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D017035:Pravastatin