Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.
(5-Azidonaphthalene-1-sulfonamidoethyl)-5-O-(alpha-arabinofuranosyl)-alpha-D-arabinofuranoside 1 was synthesized as a photoaffinity probe for the determination of arabinosyl transferase activity and for the identification of binding and functional sites in Mycobacterium tuberculosis.
Pathak
Ashish K
AK
Department of Organic Chemistry, Southern Research Institute, Birmingham, AL 35255, USA.
Pathak
Vibha
V
Gurcha
Sudagar S
SS
Besra
Gurdyal S
GS
Reynolds
Robert C
RC
D000995:Antitubercular Agents / Q000494:pharmacology; D004187:Disaccharides / Q000138:chemical synthesis*; D004977:Ethambutol / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology*; D010430:Pentosyltransferases / Q000378:metabolism*; D019920:Photoaffinity Labels / Q000138:chemical synthesis*; D016339:Spectrometry, Mass, Fast Atom Bombardment
C471467:(5-azidonaphthalene-1-sulfonamidoethyl)-5-O-(arabinofuranosyl)-arabinofuranoside; D000995:Antitubercular Agents; D004187:Disaccharides; D019920:Photoaffinity Labels; D004977:Ethambutol; D010430:Pentosyltransferases; C101967:arabinosyltransferase