Powerful Claisen condensation and Claisen-aldol tandem reaction of alpha,alpha-dialkylated esters promoted by ZrCl4-iPr2NEt.
Powerful Claisen ester condensations of alpha,alpha-dialkylated esters mediated by ZrCl4-iPr2NEt were performed to give the corresponding thermodynamically unfavorable alpha,alpha-dialkylated beta-ketoesters, and Claisen-aldol tandem reactions between an intermediary Zr-enolate of a alpha,alpha-dialkylated beta-ketoester and aldehydes also proceeded.
Tanabe
Y
Y
School of Science, Kwansei Gakuin University, 1-1-155 Uegahara, Nishinomiya, Hyogo 622-8501, Japan.
Hamasaki
R
R
Funakoshi
S
S