[Effect of propofol and propofol combined with ketamine on cardiovascular system].
OBJECTIVE
To prevent blood pressure from reducing caused by injection of propofol.


METHODS
Thirty patients, ASA Grade I-II, were randomly allocated into one of the two groups: Group I (Group P, n = 15) and Group II (Group K + P, n = 15), the patients received 2 mg.kg-1 propofol in Group I and 1 mg.kg-1 ketamine before equal dose of propofol in Group II. Systolic blood pressure(SBP), diastolic blood pressure(DBP), mean blood pressure and heart rate were measured before injection and 1 min, 3 min, 5 min and 10 min respectively after injection.


RESULTS
Blood pressure in Group I was significantly lower than Group II.


CONCLUSIONS
Ketamine can attenuate the hemodynamic responses to propofol.
Lü
Z P
ZP
Department of Anensthesiology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Chen
Y P
YP
Zou
D Q
DQ
D000293:Adolescent; D000328:Adult; D019162:Anesthetics, Combined; D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000187:drug effects*; D002648:Child; D005260:Female; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007022:Hypotension / Q000517:prevention & control; D007649:Ketamine; D008297:Male; D015742:Propofol / Q000009:adverse effects*
D019162:Anesthetics, Combined; D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D007649:Ketamine; D015742:Propofol