Non-stop decay--a new mRNA surveillance pathway.
Gene expression is an inherently complex process and errors often occur during the transcription and processing of mRNAs. Several surveillance mechanisms have evolved to check the fidelity at each step of mRNA manufacture. Two recent reports describe the identification of a novel pathway in eukaryotes that recognizes and degrades mRNAs that lack a stop codon. The non-stop decay mechanism releases ribosomes stalled at the 3' end of a mRNA and stimulates the exosome to rapidly degrade the transcript.
Vasudevan
Shobha
S
Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Peltz
Stuart W
SW
Wilusz
Carol J
CJ
D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; D001665:Binding Sites; D002467:Cell Nucleus / Q000378:metabolism; D018388:Codon, Terminator; D003593:Cytoplasm / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D019204:GTP-Binding Proteins; D008954:Models, Biological; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; D018388:Codon, Terminator; D005656:Fungal Proteins; D012333:RNA, Messenger; C118668:SKI7 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D019204:GTP-Binding Proteins