Effects of oral continuous and transdermal cyclic 17-beta estradiol and norethindrone acetate replacement therapy on platelet aggregation in postmenopausal women.
OBJECTIVE
To evaluate the effects of an oral continuous and transdermal cyclic 17-beta estradiol and norethindrone acetate combination on platelet aggregation in post-menopausal women.


METHODS
Fifty postmenopausal women were randomly assigned to receive 17-beta estradiol and norethindrone acetate either orally continuously or transdermally cyclically and sequentially. Platelet counts and maximum platelet aggregation rates were measured before and after three months treatment.


RESULTS
At three months there were no significant changes in platelet counts or in adenosine diphosphate-induced or epinephrine-induced platelet aggregation rates in either treatment group.


CONCLUSIONS
Hormone replacement treatment with a 17-beta estradiol and norethindrone acetate combination either orally continuously or transdermally cyclically and sequentially does not affect platelet aggregation in postmenopausal women.
Kaplan
Petek Balkanli
PB
Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey.
Gücer
Fatih
F
Sayin
N Cenk
NC
Yüce
M Ali
MA
Yardim
Turgut
T
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000008:administration & dosage* / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009640:Norethindrone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000077563:Norethindrone Acetate; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D011446:Prospective Studies; D013997:Time Factors
D003692:Delayed-Action Preparations; D008055:Lipids; D004958:Estradiol; D000077563:Norethindrone Acetate; D009640:Norethindrone