Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy.
The authors investigated the segregation of two polymorphisms of the alpha2-macroglobulin gene (A2M-I/D and A2M-Ile1000Val) in patients with sporadic AD from southern Italy. The A2M-I and A2M-Val1000 alleles were more frequent in cases than in controls, and this effect was independent from the APOE-epsilon4 status as well as from the age at onset of AD. Moreover, subjects carrying the A2M genotype I/I-Val/Val had a threefold increase of risk for AD. These data support a population-based susceptibility for AD linked to A2M polymorphisms.
Zappia
M
M
Institute of Neurology, University Magna Graecia, Catanzaro, Italy.
Cittadella
R
R
Manna
I
I
Nicoletti
G
G
Andreoli
V
V
Bonavita
S
S
Gambardella
A
A
Quattrone
A
A
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D000511:alpha-Macroglobulins / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000511:alpha-Macroglobulins