Synthesis and anticancer evaluation of vitamin K(3) analogues.
Novel vitamin K(3) analogues were synthesized and evaluated for their anticancer activity. Compound 6, 9, 10, 11, 14, and (+/-)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, SW-480, and TW-039. Compound (+/-)15 displayed potent tumor cell cytotoxicity, and compound 14 selectively affected MCF7, even though it did not influence normal cells Detroit551 and WI-38. Compound (+/-)15 inhibited MES-SA and MES-SA/Dx5, and this specific result shows that compound (+/-)15 may become a good anticancer drug candidate.
Chen
Chinpiao
C
Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien, Taiwan, ROC. chinpiao@mail.ndhu.edu.tw
Liu
Yi-Zhong
YZ
Shia
Kak-Shan
KS
Tseng
Huan-Yi
HY
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D019450:Genes, MDR; D006801:Humans; D007202:Indicators and Reagents; D014407:Tumor Cells, Cultured; D024483:Vitamin K 3 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D024483:Vitamin K 3