title: Adult Henoch-Schönlein purpura with glomerulonephritis and paroxysmal nocturnal haemoglobinuria: an uncommon association.
abstract: Henoch-Schönlein purpura (HSP) is considered to be a small blood vessel systemic vasculitis. Numerous microorganisms have been implicated in triggering HSP. We describe an unusual case of HSP with glomerulonephritis and renal failure requiring haemodialysis in a young adult man who subsequently developed paroxysmal nocturnal haemoglobinuria (PNH) with several haemolytic episodes. Bacterial infections, especially those of the respiratory and urinary tract, might trigger both the diseases.
authors.affiliation: University of Padua, Padua, Italy. franco.cozzi@unipd.it
authors.forename: F
authors.initials: F
authors.lastname: Cozzi
authors.forename: C
authors.initials: C
authors.lastname: Botsios
authors.forename: P
authors.initials: P
authors.lastname: Ostuni
authors.forename: P
authors.initials: P
authors.lastname: Sfriso
authors.forename: E
authors.initials: E
authors.lastname: Piva
authors.forename: P
authors.initials: P
authors.lastname: Marson
authors.forename: L
authors.initials: L
authors.lastname: Punzi
authors.forename: S
authors.initials: S
authors.lastname: Todesco
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000328:Adult; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D017707:Erythrocyte Transfusion; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D018570:Risk Assessment; D016896:Treatment Outcome