[The effects of jiexinkang on the apoptosis of leukemic cells].
The effects of Chinese medicine jiexinkang(JXK) on apoptosis of leukemic cells were studied by morphology approach and electrophoresis of DNA fragments.


RESULTS
1. The apoptotic cells and apoptotic bodies were found by electrical microscopy and the typical ladders of DNA fragments were detected by electrophoresis. 2. JXK induced apoptosis of leukemic cells(HL-60 and K562) in a certain range of concentration and at appropriate time. The time to K562 cell apoptosis was longer than that of HL-60 and its dosage was larger than that of HL-60.


CONCLUSIONS
HL-60 and K562 leukemic cell apoptosis may be induced by JXK and there is correlation between dose and time. The study provides experimental evidences for the clinical treatment of leukemia.
Cao
Z H
ZH
Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Xie
Z X
ZX
Tan
D R
DR
Qin
Q
Q
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation; D004273:DNA, Neoplasm / Q000032:analysis; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018922:HL-60 Cells / Q000648:ultrastructure; D006801:Humans; D020014:K562 Cells / Q000648:ultrastructure
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal