title: A possible mechanism for the exchange of transferrin-67Ga complex to heparan sulfate-67Ga complex.
abstract: We attempted to identify the exchange mechanism of transferrin-67Ga complex to heparan sulfate-67Ga complex. The effect of phosphate on the binding ability of 67Ga to transferrin and heparan sulfate was studied by the dialysis method. The phosphate inhibited the binding ability of 67Ga to transferrin, while the phosphate enhanced the 67Ga binding ability to heparan sulfate. The results suggest that the phosphate is involved in the translocation of 67Ga from the transferrin to the heparan sulfate.
authors.affiliation: Department of Radiopharmacy, Tohoku Pharmaceutical University, Sendai, Japan. shin-abe@tohoku-pharm.ac.jp
authors.forename: Shinya
authors.initials: S
authors.lastname: Abe
authors.forename: Yositaka
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Junko
authors.initials: J
authors.lastname: Ohtsuki
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Ohkubo
mesh_terms: D001665:Binding Sites / Q000502:physiology; D005710:Gallium Radioisotopes / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
chemical_list: D005710:Gallium Radioisotopes; D006497:Heparan Sulfate; D014168:Transferrin