Effects of antenatal glucocorticoids on outcomes of very low birth weight multifetal gestations.
OBJECTIVE
The purpose of this study was to test the hypothesis that benefits of antenatal glucocorticoids to reduce death or major morbidities are similar in very low birth weight multiple and singleton infants.


METHODS
Infants with birth weight of 401 to 1500 g who were born from May 1991 through December 1999 were evaluated with the use of the National Institute for Child Health and Human Development Neonatal Research Network registry data. The generalized estimating equations approach to multivariable logistic regression was used, with interaction between multifetal gestation and antenatal glucocorticoids as the primary independent variable.


RESULTS
Mothers of multiple infants were more likely to receive antenatal glucocorticoids than mothers of singleton infants (66% vs 56%; P <.01). No interaction between multifetal gestation and antenatal glucocorticoids was noted for any study outcomes. The odds of death or major morbidity was decreased by antenatal glucocorticoids, advancing gestational age, increasing birth weight, female gender, and nonwhite race.


CONCLUSIONS
If exposed to antenatal glucocorticoids, very low birth weight infants of multifetal gestations and very low birth weight singleton infants have similar risks of death or major morbidity.
Hashimoto
Laura Nickles
LN
Division of Neonatology, Cincinnati Children's Hospital Medical Center, OH 45229-3039, USA.
Hornung
Richard W
RW
Lindsell
Christopher J
CJ
Brewer
David E
DE
Donovan
Edward F
EF
D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D005333:Fetus / Q000187:drug effects*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D009017:Morbidity; D011247:Pregnancy; D011272:Pregnancy, Multiple; D012737:Sex Factors
D005938:Glucocorticoids