Adipogenesis and fat-cell function in obesity and diabetes.
Normal metabolic balance is maintained by a complex homeostatic system involving multiple tissues and organs. Acquired or inherited defects in any part of this system can lead to metabolic disorders, such as diabetes and obesity. Adipose tissue, once thought to function primarily as a passive depot for the storage of excess lipid, is now understood to play a much more active role in metabolic regulation, secreting a variety of metabolic hormones and actively functioning to prevent deleterious lipid accumulation in other tissues. Here, we review new advances in our understanding of adipogenesis and fat-cell function, primarily from the perspective of the transcription factor peroxisome proliferator-activated receptor gamma.
Camp
Heidi S
HS
Department of Molecular Sciences and Technology, Pfizer Global Research and Development, 2800 Plymouth Rd, Ann Arbor, MI 48105, USA. heidi.camp@pfizer.com
Ren
Delin
D
Leff
Todd
T
D017667:Adipocytes / Q000378:metabolism* / Q000473:pathology; D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D009765:Obesity / Q000378:metabolism* / Q000473:pathology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors