Efficient and selective catalytic oxidative cleavage of alpha-hydroxy ketones using vanadium-based HPA and dioxygen.
The combination of H3 + n[PMo12 - nVnO 40].aq (HPA-n, n = 3) and dioxygen proides a clean and regioselective reagent for the homolytic cleavage of various representative alpha-hydroxy ketones (primaryto tertiary) and turns out to be as efficient for the catalytic ring opening of chiral natural products.
el Aakel
L
L
Laboratoire des Systèmes Interfaciaux à l'Echelle Nanométrique, Université Pierre et Marie Curie, unité CNRS 2312, case 196, 4 place Jussieu, 75252 Paris, France.
Launay
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F
Atlamsani
A
A
Brégeault
J M
JM