title: DRB1 alleles in relation to severity of liver disease in patients with chronic hepatitis C.
abstract: The aim of our study was analysis of relation between HLA class II antigens and the liver disease severity in chronic hepatitis C (CHC) patients. The subject of analysis was data obtained from 134 CHC patients with disease confirmed by histopathologic test (F/M: 62/72; age 16-74; average age 41.4 +/- 12.7 yrs), HCV RNA-positive, HbsAg- and HIV-negative with no coexistence of any other liver diseases. Liver biopsy specimens were estimated according to Ishak's criterions (grading 0-18; staging 0-6). HLA DRB1 alleles were determined by a commercial method INNOLiPA DRB (Innogenetics, Belgium). Statistical analysis considered alleles occurring with frequency higher than 10%. The necroinflammatory activity (average grading score) was compared in groups of patients with- and without particular allele. The frequency of each allele's occurrence was analyzed according to patients sex, age and staging score of liver fibrosis. In statistical analysis t-Student test and chi-squared test with or without Yates' correction were applied. Statistically significant correlation was found between occurrence of DRB1*13 and DRB1*07 alleles and necroinflammatory activity intensification, and between occurrence of DRB1*13 allele and progression of liver disease. Mild liver damage, instead, expresses statistically significant relation with DRB1*11 allele.
authors.affiliation: Probationary Infectious Diseases Department, Voivod Hospital, ul. Radiowa 7, 25-317 Kielce, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Kryczka
authors.forename: E
authors.initials: E
authors.lastname: Brojer
authors.forename: A
authors.initials: A
authors.lastname: Kalińska
authors.forename: A
authors.initials: A
authors.lastname: Urbaniak
authors.forename: D
authors.initials: D
authors.lastname: Zarebska-Michaluk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005355:Fibrosis; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains