title: Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice.
abstract: OBJECTIVE
  We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases).
  
  
  METHODS
  The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured.
  
  
  RESULTS
  Only tyrphostins and NS-398 administered 2 h before LPS successfully delayed preterm birth (p < 0.05).
  
  
  CONCLUSIONS
  Both tyrphostins AG126 and AG1288 as well as NS-398 inhibited LPS induced preterm birth to the time of normal birth.
authors.affiliation: Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Mijovic
authors.forename: Tamas
authors.initials: T
authors.lastname: Zakar
authors.forename: Dean B
authors.initials: DB
authors.lastname: Zaragoza
authors.forename: David M
authors.initials: DM
authors.lastname: Olson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009578:Nitrobenzenes / Q000494:pharmacology; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013047:Specific Pathogen-Free Organisms; D013449:Sulfonamides / Q000494:pharmacology; D020032:Tyrphostins / Q000494:pharmacology*
chemical_list: D008070:Lipopolysaccharides; D009578:Nitrobenzenes; D013449:Sulfonamides; D020032:Tyrphostins; C069028:AG 127; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D011505:Protein-Tyrosine Kinases