title: [The use of propofol combined with nitrous oxide and fentanyl in anesthetic management of a patient with mitochondrial encephalomyopathy].
abstract: A 49-year-old female with mitochondrial encephalomyopathy underwent surgery for implantation of an artificial cochlear device. She had some characteristic clinical features, including muscle weakness, deafness and dementia. Anesthesia was induced with 5 mg.kg-1 of propofol, and the trachea was intubated without a muscle relaxant. The patient was mechanically ventilated also without a relaxant, and anesthesia was maintained with a continuous infusion of 4-8 mg.kg-1.hr-1 of propofol, a bolus injection of 50-100 micrograms of fentanyl, and nitrous oxide (66%) in oxygen (33%). Bispectral index (BIS) was monitored and maintained at approximately 40. No cardiovascular instabilities or increase in plasma lactate concentration were observed during surgery. The patient had a smooth recovery from the propofol anesthesia, and the BIS value returned to the pre-anesthetic level 10 min after completion of the anesthesia, suggesting that the use of propofol is a safe means for inducing and maintaining anesthesia in patients with mitochondrial encephalomyopathy.
authors.affiliation: Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060-8543.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Shibukawa
authors.forename: Mikito
authors.initials: M
authors.lastname: Kawamata
authors.forename: Sumihiko
authors.initials: S
authors.lastname: Seki
authors.forename: Eichi
authors.initials: E
authors.lastname: Narimatsu
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Namiki
mesh_terms: D000758:Anesthesia; D019162:Anesthetics, Combined; D019929:Cochlear Implantation; D005260:Female; D005283:Fentanyl; D006801:Humans; D008875:Middle Aged; D017237:Mitochondrial Encephalomyopathies; D016343:Monitoring, Intraoperative; D009609:Nitrous Oxide; D015742:Propofol
chemical_list: D019162:Anesthetics, Combined; D009609:Nitrous Oxide; D005283:Fentanyl; D015742:Propofol