Consideration on the formulation of benzoyl peroxide at ambient temperature: choice of non-polar solvent and preparation of submicron emulsion gels.
The aim of this study performed at ambient temperature was first to determine the solubility of benzoyl peroxide in various solvents with a large range of polarity. All these solvents can be used in the dermatological field. Then, using the most suitable solvent, a new drug vehicle submicron oil-in-water emulsion was formulated. Correlation between dielectric constant (epsilon) and drug solubility in various solvents and different binary mixtures was verified. An original ternary diagram with surfactant-co-surfactant/oil/water was performed at low temperature to determine the regions of submicron emulsions. A dramatic change in the magnitude of benzoyl peroxide solubility occurred above a dielectric constant value of about 20. The solubility of this drug can be enhanced by the replacement of polar solvent by a vehicle of lower dielectric constant. A stable submicron emulsion gel was made with cremophor EL, glycerol, caprilic-capric triglycerides, and water in the proportion of 20-20/35/25, respectively; 1.5% benzoyl peroxide was also added. This submicron emulsion vehicle consisted of oil droplets, with a mean diameter of approximately 100-150 nm, dispersed in a continuous water phase. These studies confirm the potential of benzoyl peroxide incorporation into submicron emulsion gel and the stability of this formulation.
Nielloud
Francoise
F
Laboratoire de Technique Pharmaceutique Industrielle, Faculté de Pharmacie, Université de Montpellier I, France.
Mestres
Jean Paul
JP
Marti-Mestres
Gilberte
G
D001585:Benzoyl Peroxide; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004655:Emulsions; D005782:Gels; D012997:Solvents; D013696:Temperature
D004655:Emulsions; D005782:Gels; D012997:Solvents; D001585:Benzoyl Peroxide