[Immune and metabolic effects of carnitine and biotin in hemolytic anemia].
Single (80 mg/kg) or multiple (3 mg/kg) intramuscular introduction of phenylhydrazine decreases the functional activity of mononuclear blood cells and the immunological reactivity of the organism. Carnitine and biotin do not significantly influence the immunological response to a single administration of phenylhydrazine but noticeably reduce the expression of changes produced by repeated injections of the hemolytic toxin.
Lazareva
G A
GA
Biochemistry Department, Kursk State Medical University, ul. K. Marksa 3a, Kursk, 305033 Russia.
Prokopenko
L G
LG
Uteshev
B S
BS
D000743:Anemia, Hemolytic / Q000097:blood* / Q000139:chemically induced / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001710:Biotin / Q000494:pharmacology*; D002331:Carnitine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D010659:Phenylhydrazines / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar
D010659:Phenylhydrazines; C030299:phenylhydrazine; D001710:Biotin; D002331:Carnitine