title: [Food phytosterol ester efficiency on the plasma lipid reduction in moderate hypercholesterolemic subjects].
abstract: OBJECTIVE
  This study aimed at relating the pattern of response to dietary plant sterol ester (PSE) treatment of plasma lipids concentrations and apo E polymorphisms.
  
  
  METHODS
  Patients (20-60y old: 50 women; 10 men) with primary moderate hypercholesterolemia were fed margarine (20g/d), received no treatment (placebo), and were fed PSE (2.8g/d = 1.68 phytosterols), during 3 periods of 4 weeks each, in a crossover, double-blind study. DNA was extracted from white blood cells for the apo E polymorphisms.
  
  
  RESULTS
  PSE treatment significantly lowered TC and LDL-C 10% and 12%, respectively, in relation to the baseline, and 6% and 8% in relation to the placebo phase, but HDL-C and TG levels were not modified. In regard to the apo E genotyping, no significant difference occurred between apo E 3/3 and apo E (3/4).
  
  
  CONCLUSIONS
  Dietary plant sterol ester (PSE) treatment reduced cholesterolemia, and the reduction of LDL-C in absolute values was more pronounced when the initial LDL - C concentration were elevated.
authors.affiliation: Laboratorio de Lipides do Hospital das Clinicas da FMUSP, Sao Paulo, Brazil.
authors.forename: Ana M P
authors.initials: AM
authors.lastname: Lottenberg
authors.forename: Valéria S
authors.initials: VS
authors.lastname: Nunes
authors.forename: Edna R
authors.initials: ER
authors.lastname: Nakandakare
authors.forename: Mônica
authors.initials: M
authors.lastname: Neves
authors.forename: Márcia
authors.initials: M
authors.lastname: Bernik
authors.forename: José E
authors.initials: JE
authors.lastname: Santos
authors.forename: Eder C R
authors.initials: EC
authors.lastname: Quintao
mesh_terms: D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004311:Double-Blind Method; D004952:Esters; D005260:Female; D005838:Genotype; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008383:Margarine; D008875:Middle Aged; D010840:Phytosterols / Q000494:pharmacology*; D008517:Phytotherapy; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004952:Esters; D010840:Phytosterols; D014280:Triglycerides; D008383:Margarine; D002784:Cholesterol