title: New scaffolds for combinatorial synthesis. 1. 5-sulfamoylisatins and their reactions with 1,2-diamines.
abstract: 3,3-Dichloro-5-(4-methylpiperidinosulfonyl)-2-indolinone (3) and 5-sulfamoylisatins 4 have been synthesized from 5-chlorosulfonyl-3,3-dichloro-2-indolinone (1). Compounds 4 are promising scaffolds for the solid- and liquid-phase syntheses of new combinatorial libraries of various heterocycles. Thus, the reactions of 4 with 1,2-diamines, such as o-phenylenediamine (5) and aminoguanidine hydrochloride (6), 1,2-diaminoimidazoles (9), and thiosemicarbazide led, respectively, to new heterocycles 7 and 8 and new combinatorial libraries of triazinoindoles 10 and 15. Chemsets 4, 10, and 15 were isolated as crystalline solids that were purified by recrystallization from a suitable solvent and characterized by spectroscopic methods.
authors.affiliation: Chemical Diversity Labs, Inc., 11575 Sorrento Valley Road, Suite 211, San Diego, CA 92121, USA.
authors.forename: Alexandre V
authors.initials: AV
authors.lastname: Ivachtchenko
authors.forename: Alexey P
authors.initials: AP
authors.lastname: Il'yin
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Kobak
authors.forename: Denis A
authors.initials: DA
authors.lastname: Zolotarev
authors.forename: Larisa V
authors.initials: LV
authors.lastname: Boksha
authors.forename: Andrey S
authors.initials: AS
authors.lastname: Trifilenkov
authors.forename: Dina M
authors.initials: DM
authors.lastname: Ugoleva