[Antimicrobial, echinococcidial and immunostimulating properties of the drug Cheblin-SK-1].
The antimicrobial properties of the drug Cheblin-CK-1 (CCK-1) were determined in mice intraabdominally inoculated with Proteus mirabilis-4691 in a dose of 140-200 million daily cultured microbial bodies. Its comparison agent was ampicillin. CCK-1 was found to act as an antibiotic similar to ampicillin in its effects. The antimicrobial activity of CCK-1 against Staphylococcus aureus and Escherichia coli isolated from the contents of echinococcal cysts from patients operated on was also established. Its echinococcidial activity was found in experiments on the cotton rats and piglets inocculated with echinococci. CCK-1 was also tested on volunteers. Before surgery, 186 patients with echinococcosis took the drug and 26 patients with the same disease did not and they served as controls. At first the drug suppressed the growth of parasitic larvocysts with destruction and death of 85-95% of germinal elements of larvocysts and then killed parasites. In patients receiving a complete course of its therapy, protein and amino acid metabolisms restored, followed by immunity recovery.
Chebyshev
N V
NV
Streliaeva
A V
AV
Sadykov
V M
VM
Buniatian
N D
ND
Sabirov
B U
BU
Samylina
I A
IA
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D004195:Disease Models, Animal; D004443:Echinococcosis / Q000188:drug therapy* / Q000276:immunology; D004446:Echinococcus / Q000187:drug effects*; D006805:Human Experimentation; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D008297:Male; D051379:Mice; D009754:Nuts; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D011512:Proteus Infections / Q000188:drug therapy; D011513:Proteus mirabilis; D051381:Rats; D016205:Sigmodontinae; D013552:Swine
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D007155:Immunologic Factors; D010936:Plant Extracts