title: [Postpartum hypercalcemia in a patient with previous thyroid carcinoma: a report of 2 cases].
abstract: We report postpartum hypercalcemia in 2 patients with previous thyroid carcinoma who had undergone total thyroidectomy and total parathyroidectomy and required vitamin D and calcium therapy to control hypoparathyroidism. Postpartum, they required less vitamin D and calcium for satisfactory control. While lactating, they maintained normal serum calcium without supplementary vitamin D or calcium. Transient remission of hypoparathyroidism symptoms has been observed during lactation. Some studies have shown that parathyroid-related protein (PTHrP) is produced by breast tissue, having an endocrine-like effect. We discuss the mechanism of postpartum hypercalcemia.
authors.affiliation: Department of Otorhinolaryngology, Fukuoka City Hospital, Fukuoka.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Yasumatsu
authors.forename: Torahiko
authors.initials: T
authors.lastname: Nakashima
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kuratomi
authors.forename: Sohtaro
authors.initials: S
authors.lastname: Komiyama
mesh_terms: D000328:Adult; D001940:Breast / Q000378:metabolism; D002118:Calcium / Q000009:adverse effects; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007011:Hypoparathyroidism; D007774:Lactation / Q000502:physiology; D044162:Parathyroid Hormone-Related Protein; D016105:Parathyroidectomy; D036361:Peptide Hormones / Q000096:biosynthesis / Q000502:physiology; D049590:Postpartum Period; D011247:Pregnancy; D012075:Remission, Spontaneous; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy; D014807:Vitamin D / Q000009:adverse effects
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones; D014807:Vitamin D; D002118:Calcium