title: Action of carriers on Carbamazepine dissolution.
abstract: It is well known that carriers can affect the dissolution of poorly soluble drugs. In this study, our aim was to investigate the dissolution enhancement of carbamazepine solid dispersed or mixed at different loading ratios in crospovidone, polyvinylpyrrolidone, and sodium starch glycolate. The physical state of the drug and the drug-polymer interactions in the solid state were investigated using differential scanning calorimetry (DSC) and x-ray diffraction analysis (XRD). Through the solubilization kinetics and dissolution rates studies, the in vitro drug availability of the systems was evaluated. An improved in vitro dissolution of the drug was obtained in all the binary systems that increased as the polymer content increased.
authors.affiliation: Department of Pharmaceutical Sciences, University of Trieste, via Weiss 9, 34127 Trieste, Italy. moneghin@univ.trieste.it
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Moneghini
authors.forename: Dario
authors.initials: D
authors.lastname: Voinovich
authors.forename: Beatrice
authors.initials: B
authors.lastname: Perissutti
authors.forename: Francesco
authors.initials: F
authors.lastname: Princivalle
mesh_terms: D002152:Calorimetry, Differential Scanning; D002220:Carbamazepine / Q000032:analysis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004337:Drug Carriers; D007700:Kinetics; D012995:Solubility; D012997:Solvents
chemical_list: D004337:Drug Carriers; D012997:Solvents; D002220:Carbamazepine