Bioactive saponins from Dioscorea futschauensis.
A new anti-neoplastic spirostanol saponin, (25S)-spirost-5-en-3 beta, 27-diol-3O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranoside and three known compounds viz. prosapogenin A of dioscin, dioscin and gracilin were isolated from Dioscorea futschauensis by bioactivity-guided fractionation. Their structures were elucidated mainly by means of spectroscopic analysis. Their bioactivity against Pyricularia oryzae and cytotoxic activity on ts-FT210 cell line was evaluated.
Liu
H W
HW
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, China.
Hu
K
K
Zhao
Q C
QC
Cui
C B
CB
Kobayashi
H
H
Yao
X S
XS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D027742:Dioscorea / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006868:Hydrolysis; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012997:Solvents; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D012997:Solvents