title: Nasopharyngeal amyloidosis.
abstract: OBJECTIVE
  To discuss the presentation of localized amyloidosis affecting the nasopharynx and discuss the management options. Amyloidosis in the head and neck is a rare and benign condition that usually takes the form of localized amyloidosis. Because systemic amyloidosis markedly shortens life expectancy owing to its involvement with vital organs, rectal biopsy or fat aspiration of the anterior abdominal wall must be carried out to exclude systemic involvement. Localized amyloidosis in the head and neck can involve the orbit, sinuses, nasopharynx, oral cavity, salivary glands, and larynx.
  
  
  METHODS
  We present the case of a patient with conductive hearing loss and serous otitis media with effusion secondary to nasopharyngeal amyloidosis, as well as present a review of the literature.
  
  
  RESULTS
  Only a few cases of nasopharyngeal amyloidosis have thus far been reported. Patients with this disease can also present with recurrent epistaxis, postnasal drip, nasal obstruction, and eustachian tube dysfunction. Localized amyloidosis of the nasopharynx, which is slow growing, has proved difficult to treat because it can persist or recur despite surgical treatment. Furthermore, bleeding may be a major complication in treating patients with nasopharyngeal amyloidosis by transpalatal excision because the amyloid deposits cause vascular wall fragility. Finally, there is no evidence that surgical treatment of nasopharyngeal amyloidosis can prolong survival or that localized amyloidosis can progress to systemic amyloidosis. For these reasons, we elected to treat our patient with a tympanostomy tube and observation.
  
  
  CONCLUSIONS
  In the absence of systemic disease, localized amyloidosis of the nasopharynx may be treated conservatively.
authors.affiliation: Department of ENT and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Alpen
authors.initials: A
authors.lastname: Patel
authors.forename: Stefan
authors.initials: S
authors.lastname: Pambuccian
authors.forename: Robert
authors.initials: R
authors.lastname: Maisel
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D009302:Nasopharyngeal Diseases / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D011859:Radiography