[Analysis of retinoic acid in subretinal fluid in patients with rhegmatogenous retinal detachment].
To investigate the relationship between the level of retinoic acid (RA) in the subretinal fluid (SRF) and the extent of the vitreoretinopathy in 56 patients with rhegmatogenous retinal detachment, we studied the levels of RA in both SRF and serum using high liquid chromatography and also examined those levels in part of patients who took oral vitamin A 150,000 U.d-1. The results were that the level of RA in the SRF increased with the grade of the proliferative vitreoretinopathy (PVR); the levels of RA in both SRF and serum were significantly higher in the cases with vitamin A than those without. We conclude that retinoic acid metabolism between retinal pigment epithelial cells and neural epithelia was unbalanced after retinal detachment. Oral vitamin A is helpful to inhibit the genesis and development of the proliferative vitreoretinopathy.
Zhu
X H
XH
Department of Ophthalmology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Shi
Y X
YX
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012160:Retina / Q000378:metabolism*; D012163:Retinal Detachment / Q000188:drug therapy / Q000378:metabolism*; D014212:Tretinoin / Q000097:blood / Q000378:metabolism*; D014801:Vitamin A / Q000627:therapeutic use; D018630:Vitreoretinopathy, Proliferative / Q000097:blood / Q000378:metabolism*
D014801:Vitamin A; D014212:Tretinoin