title: Eruptive multiple lentigo-maligna-like lesions in a patient undergoing chemotherapy with an oral 5-fluorouracil prodrug for metastasizing colorectal carcinoma: a lesson for the pathogenesis of malignant melanoma?
abstract: Induction of multiple eruptive dermal and atypical melanocytic naevi has frequently been reported in children with malignant haematological diseases and chemotherapy-induced immunosuppression. This is the first report of an adult patient to develop multiple eruptive melanocytic skin lesions while undergoing chemotherapy with an oral 5-fluorouracil prodrug for metastasizing cancer. Our observation adds further evidence to the link between systemic (iatrogenic or intrinsic) immunosuppression and the induction of melanocyte proliferation and transformation.
authors.affiliation: Department of Dermatology, University of Regensburg Medical Center, Regensburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bogenrieder
authors.forename: Christof
authors.initials: C
authors.lastname: Weitzel
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schölmerich
authors.forename: Michael
authors.initials: M
authors.lastname: Landthaler
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Stolz
mesh_terms: D000284:Administration, Oral; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000069287:Capecitabine; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000473:pathology*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005472:Fluorouracil; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000503:physiopathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000473:pathology; D009508:Nevus, Pigmented / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D011355:Prodrugs / Q000008:administration & dosage / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil