title: Volume of rat lungs measured throughout the respiratory cycle using 19F NMR of the inert gas SF6.
abstract: The lung volumes of mechanically ventilated rats were measured over the course of the respiratory cycle using the NMR signal strength from inhaled sulfurhexafluoride. Rats with elastase-induced emphysema showed larger lung volumes and slower exhalation than control rats. For humans the technique should be able to provide lung volume measurements at least 20 times a second.
authors.affiliation: Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA. dkuethe@nmr.org
authors.forename: Dean O
authors.initials: DO
authors.lastname: Kuethe
authors.forename: Volker C
authors.initials: VC
authors.lastname: Behr
authors.forename: Stephanie
authors.initials: S
authors.lastname: Begay
mesh_terms: D000818:Animals; D005461:Fluorine; D008176:Lung Volume Measurements; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010196:Pancreatic Elastase; D011656:Pulmonary Emphysema / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013459:Sulfur Hexafluoride / Q000008:administration & dosage
chemical_list: D005461:Fluorine; D010196:Pancreatic Elastase; D013459:Sulfur Hexafluoride