title: Synthesis and anticancer evaluation of vitamin K(3) analogues.
abstract: Novel vitamin K(3) analogues were synthesized and evaluated for their anticancer activity. Compound 6, 9, 10, 11, 14, and (+/-)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, SW-480, and TW-039. Compound (+/-)15 displayed potent tumor cell cytotoxicity, and compound 14 selectively affected MCF7, even though it did not influence normal cells Detroit551 and WI-38. Compound (+/-)15 inhibited MES-SA and MES-SA/Dx5, and this specific result shows that compound (+/-)15 may become a good anticancer drug candidate.
authors.affiliation: Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien, Taiwan, ROC. chinpiao@mail.ndhu.edu.tw
authors.forename: Chinpiao
authors.initials: C
authors.lastname: Chen
authors.forename: Yi-Zhong
authors.initials: YZ
authors.lastname: Liu
authors.forename: Kak-Shan
authors.initials: KS
authors.lastname: Shia
authors.forename: Huan-Yi
authors.initials: HY
authors.lastname: Tseng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D019450:Genes, MDR; D006801:Humans; D007202:Indicators and Reagents; D014407:Tumor Cells, Cultured; D024483:Vitamin K 3 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D024483:Vitamin K 3