title: Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease.
abstract: The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.
authors.affiliation: Minden BioPharmaceuticals, Ltd, Jerusalem, Israel. pbendheim@mindset.co.il
authors.forename: Paul E
authors.initials: PE
authors.lastname: Bendheim
authors.forename: Burkhard
authors.initials: B
authors.lastname: Poeggeler
authors.forename: Eyal
authors.initials: E
authors.lastname: Neria
authors.forename: Vivi
authors.initials: V
authors.lastname: Ziv
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Pappolla
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Chain
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D016874:Neurofibrillary Tangles / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D007211:Indoles; D018696:Neuroprotective Agents; C015292:indolepropionic acid