An ion conductor that recognizes osmotically-stressed phospholipid bilayers.
A synthetic ion conductor (1), derived from cholic acid and spermine, has been found capable of recognizing osmotic stress in liposomes made from 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine [(C16:1)PC]. Thus, when large unilamellar vesicles of (C16:1)PC are placed under hypotonic conditions, the Na+/Li+ transport activity of 1 increases by as much as 1 order of magnitude, relative to isotonic conditions
Bandyopadhyay
Prasun
P
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
Bandyopadhyay
Punam
P
Regen
Steven L
SL
D017920:Antiporters / Q000737:chemistry* / Q000378:metabolism; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D009994:Osmolar Concentration; D010743:Phospholipids / Q000737:chemistry*; D010767:Phosphorylcholine / Q000737:chemistry
D017920:Antiporters; D008051:Lipid Bilayers; D008081:Liposomes; D010743:Phospholipids; C045885:sodium-lithium countertransporter; D010767:Phosphorylcholine