HLA in Egyptian children with biliary atresia.
We studied the human leukocytes antigens in 18 Egyptian children with biliary atresia (BA) without extrahepatic congenital malformations. There was a significant increased frequency of both B8 and DR3 (83.3% and 94.4% in patients with BA compared with 6.5% and 14.9% in the general population, respectively). Ten patients had the B8/DR3 haplotype. Our results support the hypothesis that genetic factors may play a role in susceptibility to BA.
A-Kader
Hassan H
HH
Department of Pediatrics, Upstate Medical University, Syracuse, New York 13210, USA.
El-Ayyouti
Moustafa
M
Hawas
Samia
S
Abdalla
Ahmed
A
Al-Tonbary
Yousif
Y
Bassiouny
Mohammed
M
Boneberg
Anna
A
El-Sallab
Shadia
S
D001656:Biliary Atresia / Q000235:genetics / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006680:HLA Antigens / Q000097:blood* / Q000235:genetics; D015795:HLA-B8 Antigen / Q000097:blood / Q000235:genetics; D015803:HLA-DR3 Antigen / Q000097:blood / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D012306:Risk
D006680:HLA Antigens; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen