Nuclear factor k B is activated in myelodysplastic bone marrow cells.
We describe a significant increase in the DNA binding activity of nuclear factor-kappa B (NF kappa B) in bone marrow cells from patients with myelodysplastic syndrome (MDS) compared with normal donor cells. Furthermore, MDS samples with increased NFkappaB activity consistently showed higher mRNA levels of NFkappaB-regulated cytokines.
Sanz
Cristina
C
Richard
Carlos
C
Prosper
Felipe
F
Fernandez-Luna
Jos Luis
JL
D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D016207:Cytokines / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D005786:Gene Expression Regulation; D006801:Humans; D008894:Milk Proteins; D009190:Myelodysplastic Syndromes / Q000378:metabolism* / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D050796:STAT3 Transcription Factor; D050799:STAT5 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism
D016207:Cytokines; D004268:DNA-Binding Proteins; D008894:Milk Proteins; D016328:NF-kappa B; D012333:RNA, Messenger; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050799:STAT5 Transcription Factor; D015534:Trans-Activators