A novel route to substituted 4-methylene-4,5-dihydroisoxazoles mediated by hafnium(IV) chloride.
Heating alkyl vinyl ketones and N-tert-butylarylmethylideneamine N-oxides in the presence of HfCl4 results in the formation of 4-methylene-4,5-dihydroisoxazoles in good yield.
Dunn
P J
PJ
Pfizer Global Research & Development (UK), Sandwich, Kent, UK CT13 9NJ.
Graham
A B
AB
Grigg
R
R
Higginson
P
P
Sridharan
V
V
Thornton-Pett
M
M