Initial report of bladder carcinoma following combined bladder-drained pancreas and kidney transplantation.
Although long-term survival of a functional allograft requiring long-term immunosuppressive therapy is responsible for higher incidence of non-urothelial cancers in renal allograft recipients than in normal population, the incidence of bladder cancer is uncommon and carcinoma of the bladder in the setting of combined kidney-pancreas transplantation has not been reported to date. We herein report a case of poorly differentiated invasive adeno-squamous cell carcinoma of the bladder following renal and bladder-drained pancreatic transplantation in a 44-yr-old lady with long-standing insulin dependent diabetes mellitus, which necessitated radical extirpation. Management implications are reviewed.
Highshaw
Ralph A
RA
Department of Urology, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
Tunuguntla
Hari S G R
HS
Perez
Richard V
RV
Gandour-Edwards
Regina
R
Evans
Christopher P
CP
D000328:Adult; D018196:Carcinoma, Adenosquamous / Q000150:complications / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000379:methods; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000209:etiology* / Q000628:therapy