title: Coexistence of impairment of endothelium-derived nitric oxide and platelet-derived nitric oxide in patients with coronary risk factors.
abstract: Impairment of endothelium-derived nitric oxide (EDNO) has been demonstrated in patients with coronary risk factors in some studies, as well as impaired platelet-derived nitric oxide (PDNO) in other studies. However, no study has examined whether these impairments coexist. In 24 patients with coronary risk factors, femoral vascular endothelial function was assessed with acetylcholine (ACh: 50, 100, 200 and 400 microg/min) and endothelium-independent vascular function with nitroglycerin (NTG; 50, 100, 200 microg/min) using a Doppler flow-wire technique, as well as ADP (5 micromol/L)-induced PDNO release with an NO-specific electrode. The ACh-mediated percent change in femoral vascular resistance index (% change of FVRI) and PDNO release had a significant correlation with the number of risk factors. The ACh-mediated % change of FVRI, but not that with NTG, significantly correlated with the PDNO release. Both EDNO and PDNO bioactivities are impaired in patients with coronary risk factors and there is a common mechanism.
authors.affiliation: Department of Internal Medicine III, Cardiovascular Research Institute, Kurume University School of Medicine, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Katoh
authors.forename: Hisao
authors.initials: H
authors.lastname: Ikeda
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takajo
authors.forename: Nobuya
authors.initials: N
authors.lastname: Haramaki
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shintani
authors.forename: Seiji
authors.initials: S
authors.lastname: Kanaya
authors.forename: Shinji
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ueno
authors.forename: Tomoki
authors.initials: T
authors.lastname: Honma
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Imaizumi
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005263:Femoral Artery / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D012307:Risk Factors; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide; D000109:Acetylcholine