The energy-transducing NADH: quinone oxidoreductase, complex I.
The energy-transducing NADH: quinone (Q) oxidoreductase (complex I) is the largest and most complicated enzyme complex in the oxidative phosphorylation system. Complex I is a redox pump that uses the redox energy to translocate H(+) (or Na(+)) ions across the membrane, resulting in a significant contribution to energy production. The need to elucidate the molecular mechanisms of complex I has greatly increased. Many devastating neurodegenerative disorders have been associated with complex I deficiency. The structural and functional complexities of complex I have already been established. However, intricate biogenesis and activity regulation functions of complex I have just been identified. Based upon these recent developments, it is apparent that complex I research is entering a new era. The advancement of our knowledge of the molecular mechanism of complex I will not only surface from bioenergetics, but also from many other fields as well, including medicine. This review summarizes the current status of our understanding of complex I and sheds light on new theories and the future direction of complex I studies.
Yano
Takahiro
T
Department of Biochemistry and Biophysics, School of Medicine, Johnson Research Foundation, University of Pennsylvania, Philadelphia, PA 19104-6059, USA. yano@mail.med.upenn.edu
D005075:Biological Evolution; D042967:Electron Transport Complex I; D004734:Energy Metabolism; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000201:enzymology; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D009247:NADH, NADPH Oxidoreductases; D042967:Electron Transport Complex I