A new practical ketone synthesis directly from carboxylic acids: first application of coupling reagents in palladium catalysis.
A new palladium-catalyzed cross-coupling reaction between arylboronic acids and carboxylic acids, activated in situ for the oxidative addition to a tricyclohexylphosphine palladium(0) catalyst by treatment with di(N-succinimidyl) carbonate (DSC) is disclosed, which allows the high-yielding synthesis of various functionalized arylketones under mild conditions.
Goossen
L J
LJ
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany. goossen@mpi-muelheim.mpg.de
Ghosh
K
K