[Apoptosis-inducing and anti-tumor effect of cyclophosphamide, cisplatin and adriamycin used separately or combined in murine lymphosarcoma LS].
The investigation deals with antitumor effect of cyclophosphamide, platin and adriamycin on transplantable mouse lymphosarcoma LS. It was found that the effect of the most potent drug cyclophosphamide is mediated mostly by apoptosis, while those of platin and adriamycin--by apoptosis and necrosis of tumor cells. When a combination of two or three drugs was used the necrotic effect increased proportionally, while the apoptotic one decreased. However, the overall antitumor effect did not exceed that of the one drug which induced apoptosis most effectively.
Nikolin
V P
VP
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk.
Kaledin
V I
VI
Baĭmak
T Iu
TIu
Galiamova
M R
MR
Popova
N A
NA
Voĭtsitskiĭ
V E
VE
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009336:Necrosis; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin