title: Dopamine modulation of activity of cat sensorimotor cortex neurons during conditioned reflexes.
abstract: The effects of iontophoretic application of dopamine and selective D1 or D2 dopamine receptor agonists and antagonists on impulse activity of neurons of the deep layers of the sensorimotor cortex of cat were investigated during performance of a conditioned paw movement task. The application of dopamine, Quinpirole (selective D2 receptor agonist) or SKF 38393 (selective D1 receptor agonist) increased both background (P<0.001) and evoked impulse activity (P<0.05 for selective agonists). Selective D2 and D1 receptor antagonists (Sulpiride and SKF 83566, respectively) both increased the latency of neural responses and significantly increased the latency of the conditioned paw movements (P<0.01). These data suggest that during natural physiological functions subcortical dopamine neurons provide facilitation of activity pyramidal neurons of sensorimotor cortex.
authors.affiliation: Bogomoletz Institute of Physiology, Bogomoletz str. 4, 01024, Kyiv, Ukraine. torvik@serv.kiev.ua
authors.forename: V M
authors.initials: VM
authors.lastname: Storozhuk
authors.forename: V I
authors.initials: VI
authors.lastname: Khorevin
authors.forename: N M
authors.initials: NM
authors.lastname: Rozumna
authors.forename: A E P
authors.initials: AE
authors.lastname: Villa
authors.forename: I V
authors.initials: IV
authors.lastname: Tetko
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004347:Drug Interactions; D004576:Electromyography / Q000187:drug effects; D008297:Male; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D019257:Quinpirole / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D004298:Dopamine; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D019257:Quinpirole; D013469:Sulpiride; C044846:SKF83566