Forebrain circumventricular organs mediate salt appetite induced by intravenous angiotensin II in rats.
Two circumventricular organs, the subfornical organ (SFO) and organum vasculosum laminae terminalis (OVLT), may mediate salt appetite in response to acute intravenous infusions of angiotensin (ANG) II. Fluid intakes and mean arterial pressures were measured in rats with sham lesions or electrolytic lesions of the SFO or OVLT during an intravenous infusion of 30 ng/min ANG II. Beginning 21 h before the 90-min infusion, the rats were depleted of sodium with furosemide and given a total of 300 mg/kg captopril in 75 ml/kg water in three spaced gavages to block the usual salt appetite and to hydrate the rats. No other food or fluids were available for ingestion. Sham-lesioned rats drank 9.3+/-1.2 ml if 0.3 M NaCl alone was available and drank 8.9+/-1.6 ml of saline and 3.7+/-1.6 ml of water if both were available. Either SFO or OVLT lesions reduced the intakes of saline to <5 ml in both conditions and of water to <1 ml. Mean arterial pressure did not differ among the groups and was maintained above 100 mmHg after the depletion and captopril treatments because of the large doses of water. Thus, a full expression of salt appetite in response to an acute intravenous infusion of ANG II requires the integrity of both the SFO and OVLT.
Morris
Michael J
MJ
Department of Psychology, University of Washington, Box 351525, Seattle, WA 98195-1525, USA.
Wilson
Wendy L
WL
Starbuck
Elizabeth M
EM
Fitts
Douglas A
DA
D000804:Angiotensin II / Q000494:pharmacology* / Q000502:physiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007031:Hypothalamus / Q000293:injuries / Q000502:physiology*; D007275:Injections, Intravenous; D008297:Male; D016548:Prosencephalon / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D012965:Sodium Chloride; D017673:Sodium Chloride, Dietary; D013356:Subfornical Organ / Q000293:injuries / Q000502:physiology*; D013997:Time Factors; D014867:Water
D000806:Angiotensin-Converting Enzyme Inhibitors; D017673:Sodium Chloride, Dietary; D014867:Water; D000804:Angiotensin II; D012965:Sodium Chloride; D002216:Captopril