A new synthesis of 1-chloroalkynes.
4-Unsubstituted isoxazolinones derived from the corresponding beta-ketoesters can be chlorinated and converted into 1-chloroalkynes upon treatment with sodium nitrite and ferrous sulfate in aqueous acetic acid.
Huppé
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Laboratoire de Syntèse Organique associé au CNRS, Ecole Polytechnique, 91128 Palaiseau, France.
Rezaei
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Zard
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