title: HEC-1 cells.
abstract: HEC-1 cell line was the first in vitro cell line of a human endometrial adenocarcinoma which enabled us to perform research work on the endometrium and endometrial carcinoma at a simplified cellular system, contributing cell and molecular biological studies on endometrial carcinoma. Once a cell line is established, it provides a stable experimental system that facilitates and progresses in the study of the tissues and/or neoplasias from which they are derived. In this article we report how HEC-1 cells have been established and cleared the proposed requirements to characterize the established cell line. Also to show the usefulness of the cell line for research work, once it was established, we illustrate these concepts by recalling results obtained with HEC-1 cells and reviewing the literature on what has been achieved by using these cells.
authors.affiliation: Department of Clinical Cytology Graduate School of Medical Sciences, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan. kuramoto@cc.ahs.kitasato-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kurarmoto
authors.forename: Mieko
authors.initials: M
authors.lastname: Hamano
authors.forename: Manami
authors.initials: M
authors.lastname: Imai
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D054304:Anti-Mullerian Hormone; D004268:DNA-Binding Proteins / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D000074008:MDS1 and EVI1 Complex Locus Protein; D011519:Proto-Oncogenes; D011960:Receptors, Estrogen / Q000378:metabolism; D017978:Receptors, Growth Factor / Q000378:metabolism; D013735:Testicular Hormones; D014157:Transcription Factors; D014407:Tumor Cells, Cultured
chemical_list: D004268:DNA-Binding Proteins; D004967:Estrogens; D006023:Glycoproteins; D006131:Growth Inhibitors; D006133:Growth Substances; D000074008:MDS1 and EVI1 Complex Locus Protein; C063575:MECOM protein, human; D011960:Receptors, Estrogen; D017978:Receptors, Growth Factor; D013735:Testicular Hormones; D014157:Transcription Factors; D054304:Anti-Mullerian Hormone; D000469:Alkaline Phosphatase