title: [A case of perforative peritonitis complicated with lung and intestinal severe tuberculosis].
abstract: A 27-year-old man was admitted to our hospital in September 18, 2000, complaining of fever, cough, appetite loss and body weight loss. He was diagnosed as advanced lung tuberculosis, because of chest X-ray findings and positive acid-fast bacilli in his sputum. He was administrated rifampicin (RFP), isoniazid (INH) and ethambutol (EB). Two days after starting treatment he complained of abdominal pain and the signs of perforating peritonitis. Emergency laparotomy was performed and we observed multiple ulcers and a perforation of ileum. We resected a part of distal ileum and ascending colon and made ileostomy. Histopathologic examination of resected ileum and colon showed multiple ulcers and epithelioid cell granulomas with caseous necrosis. Many acid bacilli were identified from the lesion by specially stained tissue sections. He was administrated streptomycin and INH by injection post-operatively while oral administration was impossible. Six days after the first operation, we found the signs of perforation in another part of the ileum. So we were obliged to perform second laparotomy and resect the part involved. Five days after the second operation, he was able to take RFP, INH, and levofloxacin per oral route. On February 8, 2001 we performed ileocolonal reconstruction with side to side anastomosis and closed ileostomy at the third laparotomy. He had continued chemotherapy and went back to Korea in April 7, 2001. Although intestinal tuberculosis has sharply declined in Japan thanks to development of effective antituberculous drugs, we should keep in mind that it could be a possible cause of the acute abdomen.
authors.affiliation: Department of Chest Medicine, School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-shi, Chiba 260-8677, Japan. fkuroda@insei.m.chiba-u.ac.jp
authors.forename: Fuminobu
authors.initials: F
authors.lastname: Kuroda
authors.forename: Takenori
authors.initials: T
authors.lastname: Yagi
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamagishi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hamaoka
authors.forename: Hiromi
authors.initials: H
authors.lastname: Higurashi
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D003106:Colon / Q000601:surgery; D006801:Humans; D007081:Ileostomy; D007082:Ileum / Q000601:surgery*; D007416:Intestinal Perforation / Q000209:etiology* / Q000601:surgery*; D007564:Japan; D007723:Korea / Q000208:ethnology; D007813:Laparotomy; D008297:Male; D014395:Peritonitis, Tuberculous / Q000209:etiology*; D012008:Recurrence; D012086:Reoperation; D012720:Severity of Illness Index; D014385:Tuberculosis, Gastrointestinal / Q000150:complications*; D014397:Tuberculosis, Pulmonary / Q000150:complications*
chemical_list: D000995:Antitubercular Agents