35 years of experimental research in transmyocardial revascularization: what have we learned?
In the past 35 years many experimental studies have been performed to investigate the revascularization potential of transmyocardial revascularization and the possible working mechanisms underlying the observed clinical improvement in angina pectoris after this treatment. In this review of the experimental literature, the various methods that have been used to create transmyocardial channels and the most supported hypotheses on the working mechanism (channel patency, angiogenesis and myocardial denervation) are discussed and evaluated.
Huikeshoven
Menno
M
Laser Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.huikeshoven@amc.uva.nl
Beek
Johan F
JF
van der Sloot
Jos A P
JA
Tukkie
Raymond
R
van der Meulen
Jan
J
van Gemert
Martin J C
MJ
D000818:Animals; D006352:Heart Ventricles / Q000601:surgery*; D006801:Humans; D053685:Laser Therapy; D017202:Myocardial Ischemia / Q000601:surgery*; D009204:Myocardial Revascularization / Q000379:methods*; D010043:Outcome and Process Assessment, Health Care