[The in vitro release kinetics of Daunorubicin polybutylcyanoacrylate nanoparticles].
The in vitro release kinetics of Daunorubicin Polybutylcyanoacrylate Nanoparticles(DNR-PBCA-NP) was studied by dynamic dialysis system. The concentration of Daunorubicin was determined by spectrophotometry. The result showed the in vitro release kinetics of DNR-PBCA-NP could be well characterized by a biexponential equation. There were two phases in the process of drug release. The initial phase was a fast release phase (the burst effect). The second phase was a slow release phase.
Peng
Y
Y
Department of Pharmaceutics, School of Pharmacy, WCUMS, Chengdu 610041.
Liao
G
G
Zhang
Z
Z
D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics*; D003630:Daunorubicin / Q000493:pharmacokinetics*; D004659:Enbucrilate / Q000493:pharmacokinetics*; D008962:Models, Theoretical; D010316:Particle Size
D000903:Antibiotics, Antineoplastic; D004659:Enbucrilate; D003630:Daunorubicin