[Study on the pharmacokinetics of the liver targeted mitoxantrone polylactic acid extended-release nanoparticles in rabbits].
HPLC was used to analyse the drug concentrations in blood. The 3p87 (practical pharmacokinetic program-version) was used to calculate the parameters of DHAQ-PLA-NP lyophilization injection and DHAQ injection through i.v. administration in rabbit blood. The concentration-time curves of the two kinds of preparations were in keeping with the three-compartment model. The drug concentrations were calculated according to the selecting pharmaceutical model and parameters. The calculated drug concentrations agreed well with the observed. The lyophilization injection sustained the eliminating process in vivo.
Xu
C
C
Lab of Pharmaceutics, School of Pharmacy, WCUMS, Chengdu 610041.
Liao
G
G
Wang
S
S
Zhang
Z
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D019344:Lactic Acid / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism*; D008942:Mitoxantrone / Q000493:pharmacokinetics*; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000493:pharmacokinetics; D011817:Rabbits
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D008942:Mitoxantrone