Longitudinal personality changes among presymptomatic Huntington disease gene carriers.
OBJECTIVE
To determine whether longitudinal changes in personality as measured by the Minnesota Multiphasic Personality Inventory (MMPI) can be detected among clinically presymptomatic individuals carrying the expanded Huntington disease (HD) allele.


BACKGROUND
Emotional symptoms are considered one of the cardinal features of HD. However, the literature is replete with conflicting reports of psychiatric symptoms in presymptomatic HD gene carriers.


METHODS
A longitudinal, case-control, double-blind study comparing presymptomatic gene carriers and nongene carriers at risk for HD evaluated with an abbreviated MMPI and a quantified neurologic rating scale examined an average of 3.7 years apart.


RESULTS
Presymptomatic gene carriers (PSGC) had a greater increase in abnormality over time for the MMPI scales, cynical hostility (repeated-measures ANOVA, = 0.04) and irritability (repeated measures ANOVA, = 0.005), when compared with the nongene carriers (NGC). Among both the PSGCs and NGCs, no significant correlation was found between the number of CAG repeats and the change in MMPI score between visits.


CONCLUSIONS
This study provides significant evidence for increasing irritability and cynical hostility in presymptomatic gene carriers before the onset of overt clinical symptoms.
Kirkwood
Sandra Close
SC
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA.
Siemers
Eric
E
Viken
Richard
R
Hodes
M E
ME
Conneally
P Michael
PM
Christian
Joe C
JC
Foroud
Tatiana
T
D000328:Adult; D016022:Case-Control Studies; D004311:Double-Blind Method; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology*; D008137:Longitudinal Studies; D008950:MMPI; D008297:Male; D008875:Middle Aged; D010551:Personality; D013997:Time Factors