title: Association between preheparin serum lipoprotein lipase mass and acute myocardial infarction in Japanese men.
abstract: A sensitive immunoassay system using a specific monoclonal antibody against lipoprotein lipase (LPL) recently demonstrated the presence of an LPL mass in preheparin serum. We reported that a preheparin serum LPL mass (pre-LPL mass) reflected the level of functioning LPL activity in the whole body and could be deeply involved in the progression of coronary atherosclerosis of stable organic angina pectoris. We examined the relation between the pre-LPL mass and acute myocardial infarction (AMI). We studied 44 males with AMI (AMI group) and 16 males with a normal coronary artery (NCA group), and measured the pre-LPL mass by enzyme-linked immunosorbent assay. Coronary risk factors including the pre-LPL mass were compared between the two groups and multiple regression analysis was performed for AMI. There were no significant differences in the lipid data, but the pre-LPL mass level was significantly low in the AMI group (52 +/- 16 vs 41 +/- 14 ng/ml, p = 0.01), and a low pre-LPL mass concentration was observed in the small sized LDL group and/or the Midband positive group. Multiple regression analysis revealed that a low pre-LPL mass and hypertriglyceridemia were independent risk factors for AMI (t value = 2.1, 2.4). The result indicates that a low pre-LPL mass may be an important risk factor for AMI and stable organic angina pectoris.
authors.affiliation: Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University, Sakura-City, Chiba, Japan. ddda@cc.rim.or.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hitsumoto
authors.forename: Kunio
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Kaneyuki
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sakurai
authors.forename: Masahito
authors.initials: M
authors.lastname: Kanai
authors.forename: Takashi
authors.initials: T
authors.lastname: Uchi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Noike
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Ohsawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Kohji
authors.initials: K
authors.lastname: Shirai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008071:Lipoprotein Lipase / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology*; D010316:Particle Size; D012044:Regression Analysis; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D008077:Lipoproteins, LDL; D008071:Lipoprotein Lipase