[Gene expression of Interleukin 1 in vitamin A and proteins deficiency].
The influence of low levels of protein and vitamin A on indicators of the immune response was assayed in rats. The levels of protein and vitamin A intake of the Cuban population affected by epidemic neuropathy in 1993 was reproduced in 4 diets: control, protein deficiency (DP), vitamin A deficiency (DA), protein and vitamin A deficiency (DAP). The Peyer's patches evaluated the Interleukin 1 expression gene and was related with corporal weight, food intake, serum protein, vitamin A, immunology indicators and histology evaluation (spleen, thymus and liver). Protein deficiency generated a significant decrease of the expression gene of Interleukin 1. Atrophy signs in lymphoid tissues and morphologic changes in the liver were associated with the dietary protein utilization. Protein and vitamin A deficiency generated significant stimulation of the Interleukin 1 expression gene with increase of the level of the inflammatory state indicators as serum alpha protein, total complement and neutrophils. This stimulation could be generated by a deficient retinol mobilization to tissues. These results support the hypothesis of the function of cytokines as mediators of subclinical symptoms of the immune system during the nutritional affectations.
Sánchez Alvarez
Vivian
V
Departamento de Bioquímica y Fisiología Instituto de Nutrición e Higiene de los Alimentos-Cuba.
Hernández Triana
Manuel
M
Abreu Peñate
Mario
M
de las Cagigas Reig
Ada
A
Tam Hurtado
Miguel
M
Reboso Pérez
José
J
Noa Puig
Miriam
M
Arias Verdé
José
J
Fernández Carriera
Rebeca
R
González Calderín
Soraya
S
Sigarroa González
Antonio
A
D000818:Animals; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage; D004195:Disease Models, Animal; D004435:Eating; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D009752:Nutritional Status; D011488:Protein Deficiency / Q000235:genetics / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014801:Vitamin A / Q000097:blood / Q000378:metabolism; D014802:Vitamin A Deficiency / Q000235:genetics / Q000276:immunology*
D004044:Dietary Proteins; D007375:Interleukin-1; D014801:Vitamin A