title: Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth.
abstract: The antidiarrhoeal activity of the seed extract of Albizzia lebbeck (Benth.) was investigated employing conventional rodent models of diarrhoea, i.e. castor oil-induced diarrhoea, upper gastrointestinal transit (u.g.t.) and fluid secretion. It was found that the aqueous methanol extract of Albizzia lebbeck seeds (2.5-5 mg/kg i.p.) possessed antidiarrhoeal activity which strengthens the earlier use of the seeds in the treatment of diarrhoea and dysentery. The antidiarrhoeal dose of the extract was at least 10-30 times less than the LD(50) dose. The extract (2.5-5 mg/kg i.p.) potentiated the antidiarrhoeal activity of loperamide (1 mg/kg i.p.). Nalaxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract.
authors.affiliation: Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta 700 032, India.
authors.forename: S E
authors.initials: SE
authors.lastname: Besra
authors.forename: A
authors.initials: A
authors.lastname: Gomes
authors.forename: L
authors.initials: L
authors.lastname: Chaudhury
authors.forename: J R
authors.initials: JR
authors.lastname: Vedasiromoni
authors.forename: D K
authors.initials: DK
authors.lastname: Ganguly
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000627:therapeutic use*; D002368:Castor Oil / Q000008:administration & dosage; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D007887:Fabaceae; D005772:Gastrointestinal Transit / Q000187:drug effects; D007928:Lethal Dose 50; D008139:Loperamide / Q000494:pharmacology; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D023382:Toxicity Tests, Acute
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D009270:Naloxone; D008139:Loperamide; D002368:Castor Oil