title: InterPro: an integrated documentation resource for protein families, domains and functional sites.
abstract: The exponential increase in the submission of nucleotide sequences to the nucleotide sequence database by genome sequencing centres has resulted in a need for rapid, automatic methods for classification of the resulting protein sequences. There are several signature and sequence cluster-based methods for protein classification, each resource having distinct areas of optimum application owing to the differences in the underlying analysis methods. In recognition of this, InterPro was developed as an integrated documentation resource for protein families, domains and functional sites, to rationalise the complementary efforts of the individual protein signature database projects. The member databases - PRINTS, PROSITE, Pfam, ProDom, SMART and TIGRFAMs - form the InterPro core. Related signatures from each member database are unified into single InterPro entries. Each InterPro entry includes a unique accession number, functional descriptions and literature references, and links are made back to the relevant member database(s). Release 4.0 of InterPro (November 2001) contains 4,691 entries, representing 3,532 families, 1,068 domains, 74 repeats and 15 sites of post-translational modification (PTMs) encoded by different regular expressions, profiles, fingerprints and hidden Markov models (HMMs). Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL (2,141,621 InterPro hits from 586,124 SWISS-PROT and TrEMBL protein sequences). The database is freely accessible for text- and sequence-based searches.
authors.affiliation: EMBL Outstation, European Bioinformatics Institute, Hinxton, Cambridge, UK. mulder@ebi.ac.uk
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Mulder
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
authors.forename: Terri K
authors.initials: TK
authors.lastname: Attwood
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Alex
authors.initials: A
authors.lastname: Bateman
authors.forename: David
authors.initials: D
authors.lastname: Binns
authors.forename: Margaret
authors.initials: M
authors.lastname: Biswas
authors.forename: Paul
authors.initials: P
authors.lastname: Bradley
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
authors.forename: Phillip
authors.initials: P
authors.lastname: Bucher
authors.forename: Richard
authors.initials: R
authors.lastname: Copley
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Courcelle
authors.forename: Richard
authors.initials: R
authors.lastname: Durbin
authors.forename: Laurent
authors.initials: L
authors.lastname: Falquet
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Fleischmann
authors.forename: Jerome
authors.initials: J
authors.lastname: Gouzy
authors.forename: Sam
authors.initials: S
authors.lastname: Griffith-Jones
authors.forename: Daniel
authors.initials: D
authors.lastname: Haft
authors.forename: Henning
authors.initials: H
authors.lastname: Hermjakob
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hulo
authors.forename: Daniel
authors.initials: D
authors.lastname: Kahn
authors.forename: Alexander
authors.initials: A
authors.lastname: Kanapin
authors.forename: Maria
authors.initials: M
authors.lastname: Krestyaninova
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Lopez
authors.forename: Ivica
authors.initials: I
authors.lastname: Letunic
authors.forename: Sandra
authors.initials: S
authors.lastname: Orchard
authors.forename: Marco
authors.initials: M
authors.lastname: Pagni
authors.forename: David
authors.initials: D
authors.lastname: Peyruc
authors.forename: Chris P
authors.initials: CP
authors.lastname: Ponting
authors.forename: Florence
authors.initials: F
authors.lastname: Servant
authors.forename: Christian J A
authors.initials: CJ
authors.lastname: Sigrist
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D007255:Information Services; D020407:Internet; D011506:Proteins / Q000737:chemistry / Q000145:classification; D012984:Software
chemical_list: D011506:Proteins