Comparison of the Inhibitory Effects of Quercetin and Rutin on the Oxidative Modification of LDL induced By Fe(2+)Cu(2+).
Using the oxidative modification of low density lipoprotein (LDL) as a model and the content of thiobabituric acid reactive substances (TBARS) s an index, the inhibitory effects of quercetin and rutin on oxidative modification of LDL induced by Fe(2+) and Cu(2+) were compared. The results showed that the rates of oxidative modification of LDL induced by Fe(2+) and Cu(2+) were similar in 0.15 mM NaCl (pH 7.4). The inhibitory action of quercetin on the oxidative modification of LDL induced by Cu(2+) was slightly more effective than in the case of induction by Fe(2+), and the action of rutin on the oxidation modification induced by Fe(2+) was significantly more effective than in the case of induction by Cu(2+).
Yan
Dao-Guang
DG
Research Laboratory of Free Radical Medicine, the First Military Medical University, Guangzhou 510515, China.
Zhou
Mei
M
Chen
Yuan
Y