Prognostic implications of admission inflammatory profile in acute ischemic neurological events.
OBJECTIVE
To reveal the potential prognostic implications of admission inflammatory markers in patients with acute ischemic neurological events.


METHODS
Sixty patients with an acute ischemic neurological event who were examined within 24 h from the appearance of symptomatology. We determined the high-sensitive C-reactive protein (hs-CRP) concentrations, erythrocyte sedimentation rate (ESR), fibrinogen concentrations and degree of erythrocyte adhesiveness/aggregation.


RESULTS
A significant correlation was noted between baseline hs-CRP concentrations, ESR as well as adhesiveness/aggregation and the outcome of the ischemic neurological event as determined by the modified Rankin scale 8-12 months following the insult.


CONCLUSIONS
Admission inflammatory markers have long-term prognostic implications in patients with acute ischemic neurological events. These findings are relevant in view of the new therapeutic interventions now available for reducing the inflammatory response.
Anuk
T
T
Department of Neurology and the Stroke Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Assayag
E B
EB
Rotstein
R
R
Fusman
R
R
Zeltser
D
D
Berliner
S
S
Avitzour
D
D
Shapira
I
I
Arber
N
N
Bornstein
N M
NM
D000208:Acute Disease; D000368:Aged; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003955:Diagnostic Tests, Routine; D004903:Erythrocyte Aggregation; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012494:Sampling Studies; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology
D005340:Fibrinogen; D002097:C-Reactive Protein