Quinidine does not affect the renal clearance of moxonidine.
OBJECTIVE
To test the hypothesis that the renal clearance of moxonidine decreases when dosed with quinidine.


METHODS
A randomized, two-period study was conducted with six healthy, male subjects orally dosed with either 0.2 mg moxonidine alone or 1 h after 400 mg quinidine sulphate. Pharmacokinetic parameters were calculated using a noncompartmental analysis method.


RESULTS
When coadministered, quinidine significantly increased moxonidine AUC and t1/2 by 11% and 15%, respectively, and decreased CL/F by 10% compared with the control dosing. CLR and Aeur were not significantly different. Clinically, both treatments were well tolerated.


CONCLUSIONS
Quinidine does not affect the renal clearance of moxonidine. The decrease in apparent total clearance of moxonidine with quinidine coadministration was possibly due to metabolic inhibition, though not likely to be clinically significant.
Wise
Stephen D
SD
Lilly-NUS Centre for Clinical Pharmacology, National University of Singapore, Singapore. sdw@lilly.com
Chan
Clark
C
Schaefer
Hans G
HG
He
Minxia M
MM
Pouliquen
Isabelle J
IJ
Mitchell
Malcolm I
MI
D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004338:Drug Combinations; D004347:Drug Interactions; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D011802:Quinidine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
D000959:Antihypertensive Agents; D004338:Drug Combinations; D007093:Imidazoles; C043482:moxonidine; D011802:Quinidine