One-generation reproduction toxicity study of Dithane M-45 (mancozeb) and lead acetate.
The reproductive toxicity of lead acetate and of a fungicide formulation (Dithane M-45) containing 80% mancozeb was studied on rats. Lead acetate was applied in the feed in the following dose groups: control, 1,000, 5,000 and 10,000 mg/kg of diet. The three treatment groups received, in addition to the above doses of lead acetate, 4,500 mg/kg Dithane M-45 in the diet. The method was based on the OECD Guideline for Testing of Chemicals No. 415 (1981). Clinical symptoms and mortality were not found in the parent generation. The body weight of female animals decreased significantly before the pregnancy period. This tendency was also seen in males after the combination treatment. At the two high dose levels a remarkable body weight increase was seen in the female animals during the lactation period. As a result of treatment, decreased body weight of offspring was measured during the lactation period. No gross pathological changes were seen. Histological examination showed general tubulonephrosis in the experimental animals. It can be established that the administration of Dithane M-45 did not enhance the reproductive toxicity of lead acetate.
Várnagy
L
L
Department of Zoology and Toxicology, Institute of Animal Science, Georgikon Faculty of Agriculture, University of Veszprém, H-8361 Keszthely, P.O. Box 71, Hungary. h9650var@ella.hu
Budai
P
P
Molnár
E
E
Takács
I
I
Fejes
S
S
Albert
M
M
Dobos-Kovács
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D008297:Male; D008344:Maneb / Q000633:toxicity*; D009942:Organometallic Compounds / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D015038:Zineb / Q000633:toxicity*
D005659:Fungicides, Industrial; D009942:Organometallic Compounds; D008344:Maneb; C013099:mancozeb; C008261:lead acetate; D015038:Zineb