Modeling the dynamics of DNA electrophoresis on a flat surface.
We use molecular dynamics simulations to study the mechanism by which a flat, homogeneous surface can serve as an electrophoretic separation medium for DNA. We find that the mobility of DNA on the surface is a function of the conformation of the adsorbed DNA molecule, and that this mobility is controlled by the attraction between the DNA and the surface. Our results will provide guidelines for the fabrication of surfaces that can be used to separate DNA in a wide size range.
Luo
Haobin
H
Department of Materials Science and Engineering, SUNY at Stony Brook, Stony Brook, NY 11794, USA.
Gersappe
Dilip
D
D000327:Adsorption; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D004586:Electrophoresis; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D013499:Surface Properties
D004247:DNA