[Xymedon decreases phosphatidylserine membrane expression induced by proapoptogenic deficit of serum growth factors in Jurkat T-cells].
The effect of xymedone, a non-glucoside analog of pyridine nucleosides, on the apoptosis of human CD4+ T cells of the Jurkat line was studied by laser flow cytometry method. Xymedone decreased the membrane expression of phosphatidylserine and suppressed the increase in permeability of the cytoplasmic membrane, thus inhibiting the onset of a degradation stage of the apoptotic cascade. Possible mechanisms of the antiapoptogenic effect of xymedone within the framework of a (cytochrome C/caspase 3)-dependent signal pathway of the apoptosis are discussed.
Cherepnev
G V
GV
Clinical Flow Cytometry Laboratory, Republic Medical Diagnostic Center, ul. Chekhova la, Kazan, Tatarstan, Russia.
Kern
F
F
Garaev
R S
RS
D017209:Apoptosis / Q000187:drug effects*; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D016895:Culture Media, Serum-Free; D015536:Down-Regulation; D005434:Flow Cytometry; D006133:Growth Substances / Q000172:deficiency*; D006801:Humans; D019169:Jurkat Cells; D010718:Phosphatidylserines / Q000235:genetics / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology*
D016895:Culture Media, Serum-Free; D006133:Growth Substances; D010718:Phosphatidylserines; D011743:Pyrimidines; C069705:xymedon