title: [18F]-Dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism.
abstract: There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of (18)F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.
authors.affiliation: Neurodegenerative Disorders Centre, Vancouver Hospital & Health Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Pal
authors.forename: Joanne
authors.initials: J
authors.lastname: Leung
authors.forename: Katya
authors.initials: K
authors.lastname: Hedrich
authors.forename: Ali
authors.initials: A
authors.lastname: Samii
authors.forename: Abraham
authors.initials: A
authors.lastname: Lieberman
authors.forename: Paul A
authors.initials: PA
authors.lastname: Nausieda
authors.forename: Donald B
authors.initials: DB
authors.lastname: Calne
authors.forename: Xandra O
authors.initials: XO
authors.lastname: Breakefield
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: A Jon
authors.initials: AJ
authors.lastname: Stoessl
mesh_terms: D000293:Adolescent; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000503:physiopathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004252:DNA Mutational Analysis; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D004292:Dominance, Cerebral / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008025:Ligases / Q000235:genetics*; D008297:Male; D009460:Neurologic Examination; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000235:genetics; D011699:Putamen / Q000000981:diagnostic imaging / Q000503:physiopathology; D014055:Tomography, Emission-Computed / Q000379:methods*; D044767:Ubiquitin-Protein Ligases
chemical_list: C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases