title: Crow-Fukase syndrome associated with high-output heart failure.
abstract: A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome.
authors.affiliation: Department of Internal Medicine, Saiseikai Kanazawa Hospital, Kanazawa.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Araki
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Konno
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Soma
authors.forename: Akikatsu
authors.initials: A
authors.lastname: Nakashima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takimoto
authors.forename: Yohei
authors.initials: Y
authors.lastname: Tofuku
authors.forename: Masami
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D016534:Cardiac Output, High / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016228:Endothelial Growth Factors / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D008222:Lymphokines / Q000097:blood; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors