Sensory-predominant, painful, idiopathic neuropathy: inflammatory changes in sural nerves.
Sensory-predominant, painful, idiopathic neuropathies are a common clinical problem. In this retrospective study of 11 patients with such a neuropathy, we found axonal loss in 9, with multifocal axonal loss in 4 patients; there were large perivascular mononuclear inflammatory infiltrates (>50 cells) in 4 and smaller infiltrates (10-20 cells) in 4. These findings suggest that some cases of this neuropathy may be due to autoimmune vasculopathy and therefore may respond to immunotherapy.
Kelkar
Praful
P
Department of Neurology, 2 RCP, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242, USA. praful-kelkar@uiowa.edu
McDermott
Wendy R
WR
Parry
Gareth J
GJ
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009431:Neural Conduction; D009443:Neuritis / Q000276:immunology / Q000473:pathology*; D009475:Neurons, Afferent / Q000473:pathology* / Q000648:ultrastructure; D012189:Retrospective Studies; D013497:Sural Nerve / Q000276:immunology / Q000473:pathology*; D014657:Vasculitis / Q000276:immunology / Q000473:pathology