title: Analogues of aspartic proteases synthesized by densely covering silica gel with carboxyl groups.
abstract: Aspartic protease analogues synthesized by covering the surface of silica gel with carboxyl groups effectively hydrolyzed hemoglobin and gamma-globulin. It is proposed that the carboxyl group is involved in both complexation of the protein substrate and the catalytic cleavage of the peptide bonds of the complexed proteins.
authors.affiliation: School of Chemistry and Center for Molecular Catalysis, Seoul National University, Republic of Korea.
authors.forename: Hyunsook
authors.initials: H
authors.lastname: Kim
authors.forename: Yeon-Sook
authors.initials: YS
authors.lastname: Chung
authors.forename: Hyesun
authors.initials: H
authors.lastname: Paik
authors.forename: Myoung-soon
authors.initials: MS
authors.lastname: Kim
authors.forename: Junghun
authors.initials: J
authors.lastname: Suh
mesh_terms: D000327:Adsorption; D000418:Albumins / Q000737:chemistry; D016282:Aspartic Acid Endopeptidases / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006454:Hemoglobins / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D010047:Ovalbumin / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D005719:gamma-Globulins / Q000737:chemistry
chemical_list: D000418:Albumins; D006454:Hemoglobins; D010455:Peptides; D005719:gamma-Globulins; D058428:Silica Gel; D012822:Silicon Dioxide; D010047:Ovalbumin; D016282:Aspartic Acid Endopeptidases