title: Absence of Kaposi sarcoma among Ethiopian immigrants to Israel despite high seroprevalence of human herpesvirus 8.
abstract: OBJECTIVE
  To determine the prevalence of Kaposi sarcoma (KS) and human herpesvirus 8 (HHV-8) seropositivity in Ethiopian Jewish immigrants to Israel.
  
  
  METHODS
  A Western blot assay was used to determine the seroprevalence of HHV-8 in serum samples from 202 randomly selected human immunodeficiency virus (HIV)-negative and 47 HIV-positive Ethiopian immigrants; samples were obtained on arrival of the immigrants in Israel. The Israel Cancer Registry provided comprehensive data on the occurrence of KS among Ethiopian immigrants and in the non-Ethiopian population of Israel.
  
  
  RESULTS
  A total of 39.1% and 57% of the HIV-negative and HIV-positive Ethiopians, respectively, were infected with HHV-8 (P<.03). However, none of the Ethiopians examined and none of the other HIV-negative Ethiopians among about 45,000 immigrants had KS. Moreover, only 1 (0.85%) of 118 Ethiopian patients with acquired immunodeficiency syndrome (AIDS) developed KS compared with 49 (12.5%) of 391 non-Ethiopian AIDS patients (P<.001).
  
  
  CONCLUSIONS
  Although HHV-8 infection is common in Ethiopian Jewish immigrants to Israel, these patients almost never develop KS, in marked contrast to the strong association usually observed. The mechanism behind this population's unique protection requires further study.
authors.affiliation: Central Virology Laboratory, PHL, Tel Hashomer, Israel.
authors.forename: Zehava
authors.initials: Z
authors.lastname: Grossman
authors.forename: Jose
authors.initials: J
authors.lastname: Iscovich
authors.forename: Fidi
authors.initials: F
authors.lastname: Schwartz
authors.forename: Esther
authors.initials: E
authors.lastname: Azizi
authors.forename: Avraham
authors.initials: A
authors.lastname: Klepfish
authors.forename: Ami
authors.initials: A
authors.lastname: Schattner
authors.forename: Ronit
authors.initials: R
authors.lastname: Sarid
mesh_terms: D000293:Adolescent; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D015153:Blotting, Western; D002648:Child; D016001:Confidence Intervals; D004641:Emigration and Immigration; D005002:Ethiopia / Q000208:ethnology; D005260:Female; D015658:HIV Infections / Q000150:complications; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012514:Sarcoma, Kaposi / Q000453:epidemiology* / Q000821:virology*; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral