title: [Initial scleromyxedema. Successful treatment with melphalan].
abstract: Scleromyxedema is a rare mucinous disease without thyroid dysfunction, associated with a monoclonal gammopathy. The deposits of mucin in the skin and other organs such as the cardiovasculary system, determine the prognosis of the disease. A 74-year old patient with initial scleromyxedema is described, in whom a pulse therapy with melphalan was initiated already in the early stages of the disease. Four cycles of melphalan in combination with prednisolon led to a complete and sofar stable remission of the disease.
authors.affiliation: Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Schubert
authors.forename: A
authors.initials: A
authors.lastname: Stein
authors.forename: M
authors.initials: M
authors.lastname: Meurer
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005148:Facial Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D017512:Lichenoid Eruptions / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008558:Melphalan / Q000008:administration & dosage* / Q000009:adverse effects; D009230:Myxedema / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D012867:Skin / Q000473:pathology
chemical_list: D011239:Prednisolone; D008558:Melphalan