title: Acute renal failure in neuroleptic malignant syndrome.
abstract: We report a patient with neuroleptic malignant syndrome (NMS) who developed acute renal failure and was successfully treated by hemodialysis. A 60-year-old man with a 26-year history of schizophrenia had been treated with thioridazine and sulpiride. He was admitted to our hospital for muscular rigidity and oliguria. After the diagnosis of NMS with acute renal failure was established, thioridazine and sulpiride were discontinued and hemodialysis was instituted. Renal function gradually improved and hemodialysis was discontinued after 17th treatment. We also reviewed 57 cases of NMS with acute renal failure reported in the literature. To our knowledge, 26 years is the longest latency between initiation of neuroleptic drug treatment and onset of NMS. Our review of reported NMS cases with acute renal failure identified those risks for poor prognosis as high level of BUN, age and female gender.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan. yyynnn@dl.dion.ne.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nishioka
authors.forename: Masanobu
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Susumu
authors.initials: S
authors.lastname: Kubo
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ozono
authors.forename: Takashi
authors.initials: T
authors.lastname: Harada
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000150:complications*; D006435:Renal Dialysis