Sesquiterpenes and alkaloids from Lindera chunii and their inhibitory activities against HIV-1 integrase.
Three new eudesmane type sesquiterpenoid lindenanolides E (1), F (2) and G (3), and two new aporphine alkaloid lindechunines A (18) and B (20) were isolated from roots of Lindera chunii MERR., together with seven known sesquiterpenes including a new naturally-occurring lindenanolide H (4) and eight known aporphine alkaloids. The structures of these compounds were determined by spectroscopic means. Of the isolated compounds, hernandonine (14), laurolistine (16), 7-oxohernangerine (17) and lindechunine A (18) showed significant anti-human immunodeficiency virus type 1 (HIV-1) integrase activity with IC(50) values of 16.3, 7.7, 18.2 and 21.1 microM, respectively. The major alkaloids presented in the roots of L. chunii were quantitatively analyzed by an HPLC method.
Zhang
Chao-feng
CF
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.
Nakamura
Norio
N
Tewtrakul
Supinya
S
Hattori
Masao
M
Sun
Qi-shi
QS
Wang
Zheng-tao
ZT
Fujiwara
Tamio
T
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D019427:HIV Integrase / Q000737:chemistry*; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D027443:Lindera / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D019428:HIV Integrase Inhibitors; D010936:Plant Extracts; D012717:Sesquiterpenes; D019427:HIV Integrase