A New Computer-imitated Model of Spatial Interaction between Interleukin-2 and Interleukin-2 Receptor Complex.
It is very meaningful to construct the spatial model of ligand-receptor interaction between interleukin-2 (IL-2) and interleukin-2 receptor (IL-2R) complex for the further studies in the structure-function relationship of IL-2 or IL-2R. In our study of the IL-2 molecule, we have found that Glu62 residue takes part in the binding to IL-2R alpha subunit and have confirmed that Glu126 residue in the residue bound to the IL-2R gamma subunit. In consideration with these discoveries and the progress in IL-2R subunits study, we have suggested a new model of the spatial interaction between IL-2 and IL-2R.
Wang
Zhi-Yong
ZY
Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China.
Wang
Yi-Fei
YF
Zheng
Zhong-Cheng
ZC
Liu
Xin-Yuan
XY