title: New steroidal saponins from Agave lophantha Schiede and their pharmacological evaluation.
abstract: The structures of one new monodesmosidic spirostanoside and one new bisdesmosidic furanostanol glycoside isolated from leaves of Agave lophantha Schiede have been determined by means of spectroscopic and chemical methods as (25R)-5 beta-spirostan-3 beta-ol-3-O-(beta-D-apiofuranosyl(1-->4)beta-D -glucopyranosyl(1-->3)[beta-D-glucopyranosyl(1-->2)]beta-D -galactopyranoside) and 26-O-beta-D-glucopyranosyl(25R)-5 beta-furost-20(22)-ene-3 beta, 26-diol-3-O-(beta-D-xylopyranosyl(1-->3)-[beta-D-glucopyranosyl(1--2)] beta-D-galactopyranoside), respectively. The 1H and 13C NMR resonances of the two compounds were assigned by NMR (1H, 13C, HOHAHA, 1H-1H COSY, HMQC, HMBC, NOE difference) studies. The pharmacological activities of the saponin containing fraction are discussed.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Egypt.
authors.forename: S M
authors.initials: SM
authors.lastname: Abdel-Khalik
authors.forename: T
authors.initials: T
authors.lastname: Miyase
authors.forename: F R
authors.initials: FR
authors.lastname: Melek
authors.forename: O A
authors.initials: OA
authors.lastname: el-Shabraway
authors.forename: I I
authors.initials: II
authors.lastname: Mahmoud
authors.forename: S A
authors.initials: SA
authors.lastname: Mina
mesh_terms: D027882:Agave / Q000737:chemistry*; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D002351:Carrageenan; D002492:Central Nervous System Depressants; D000431:Ethanol; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010998:Pleurisy / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids; D000431:Ethanol; D002351:Carrageenan