title: Toward the total synthesis of disorazole A(1) and C(1): asymmetric synthesis of a masked southern segment.
abstract: [reaction: see text] A highly convergent asymmetric synthesis of the masked southern segment of the antimitotic agent disorazole A(1) involves a Sonogashira coupling between a C1'-C10' enyne and a suitably protected C11'-C19' vinyl iodide. The central E,Z,Z-triene moiety is masked as a more stable ynediene.
authors.affiliation: Department of Organic Chemistry, University of Hannover, Schneiderberg 1B, Germany.
authors.forename: Ingo V
authors.initials: IV
authors.lastname: Hartung
authors.forename: Barbara
authors.initials: B
authors.lastname: Niess
authors.forename: Lars Ole
authors.initials: LO
authors.lastname: Haustedt
authors.forename: H Martin R
authors.initials: HM
authors.lastname: Hoffmann
mesh_terms: D018942:Macrolides; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D018942:Macrolides; D010080:Oxazoles; C436383:disorazole C1; C467922:disorazpole A1