[A pair-matched comparison and follow-up study of patients with euthytroid Graves ophthalmopathy and patients with hyperthyroid graves ophthalmopathy].
This study was intended to acquire a knowledge about the similarity and difference between euthyriod Graves ophthalmopathy (EGO) and hyperthyroid Graves ophthalmopathy (HGO), and about the outcome of the EGO cases. Twenty-seven EGO patients were pair-matched with 27 HGO patients, and 18 of the EGO patients were followed up for 1-6 years. The results showed that the EGO group had markedly more patients with diplopia, failure to close lids, limitation of eyeball movements, cornea involvement, and more patients with a difference of two eyes' exophthalmos degrees > or = 2 mm, but the HGO group had more patients with optic nerve involvement. No significant difference was found between the two groups' ophthalmopathic indexes by using the t-test. Drug therapy of the EGO group was more efficacious than that of the HGO group. The results of follow-up study showed that 61% of the EGO cases had hyperthyroidism and goiter within 5 months to 3 years, but 39% of the cases had no hyperthyroidism up to 6 years. These data suggest that EGO is associated with thyroid diseases and it can stand "alone" as an auto-immune disease.
Tong
N
N
Department of Endocrinology, First Affiliated Hospital, WCUMS, Chengdu 610041.
Xiao
Y
Y
Huang
H
H
Wei
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000473:pathology*; D006801:Humans; D006980:Hyperthyroidism / Q000473:pathology*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged