[Skin diseases in organ transplant patients].
In Germany 3273 visceral organs were transplanted in the year 2000. Together with patients grafted abroad, it is estimated that between 70,000 and 100,000 organ transplant patients are currently living in Germany. With the provision of lifelong immunosuppression the survival-time of these patients can exceed more than 20 years. In the first year following transplantation special emphasis is given to the prevention of viral, bacterial and fungal infections. Regular dermatological screening can provide early diagnosis of even systemic infections. An increased incidence of skin cancer parallels the extended survival rates of grafted patients. Within the first 5 years of immunosuppression 40% of these patients develop pre-malignant skin tumors such as actinic keratoses, dysplastic nevi, squamous cell carcinomas and basal cell carcinomas. Squamous cell carcinomas show an aggressive biology and an uncommon clinical morphology. The increased incidence of cancer is now responsible for a mortality rate of 5-8% in grafted patients. Against a background of lifelong immunosuppression, other risk factors include sun exposure and infections with oncogenic viruses. The rapidly growing numbers of allograft recipients as well as the rising long term survival rates of these patients demand the provision of high quality interdisciplinary and dermatological care in this field.
Ulrich
C
C
Klinik für Dermatologie, Venerologie und Allergologie, Charité, Humboldt-Universität Berlin, Germany.
Christophers
E
E
Sterry
W
W
Meyer
T
T
Stockfleth
E
E
D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D009894:Opportunistic Infections / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D012307:Risk Factors; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D014181:Transplantation Immunology / Q000276:immunology
D007166:Immunosuppressive Agents