title: BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model.
abstract: To develop a better animal model for studying the effects of the host environment in neoplasia, we injected various genetically well-characterized H-2(d) RI strains of BXD mice with syngeneic breast cancer cells (TS/A) and monitored the growth of tumors over time. There was a marked difference in the growth of the implanted breast cancer cells among the 14 BXD RI strains, with 4 patterns of tumor development being observed: in type I, the implanted tumor cells grew rapidly in the first 2 weeks, necrosis of the tumors was observed and metastases to the intestinal lymph nodes and pancreas was observed, causing death; in type II, the implanted tumor cells grew slowly and attained a size after day 50 that required killing the animal, with tumor necrosis being rare and metastases absent; in type III, the implanted tumor cells grew initially but underwent a slow decline after 4 weeks; and in type IV, the implanted tumor cells failed to develop. Apoptosis of the implanted tumor cells was responsible for the regression of tumor nodules. The T-cell immune response minimized tumor development in types III and IV since T-cell depletion of the BXD RI mice resulted in aggressively growing tumors in these strains.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, AL 35294-0007, USA.
authors.forename: William E
authors.initials: WE
authors.lastname: Grizzle
authors.forename: John D
authors.initials: JD
authors.lastname: Mountz
authors.forename: Ping-Ar
authors.initials: PA
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Sheher
authors.initials: S
authors.lastname: Sun
authors.forename: Gary E
authors.initials: GE
authors.lastname: Van Zant
authors.forename: Robert W
authors.initials: RW
authors.lastname: Williams
authors.forename: Hui-Chen
authors.initials: HC
authors.lastname: Hsu
authors.forename: Huang-Ge
authors.initials: HG
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D020022:Genetic Predisposition to Disease; D007111:Immunity, Cellular; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*; D014185:Transplantation, Isogeneic; D014407:Tumor Cells, Cultured