Transdermal absorption of a liposome-encapsulated formulation of lidocaine following topical administration in cats.
OBJECTIVE
To determine plasma disposition after dermal application of a liposome-encapsulated formulation of lidocaine in cats.


METHODS
6 healthy adult cats with a mean (+/- SD) body weight of 4.1 +/- 0.44 kg.


METHODS
CBC determination and biochemical analysis of blood samples were performed for all cats. Cats were anesthetized by use of isoflurane, and catheters were placed IV in a central vein. The next day, blood samples were obtained from the catheters before and 1, 2, 3, 4, 6, 8, 10, 12, and 24 hours after applying a 4% liposome-encapsulated lidocaine cream (15 mg/kg) to a clipped area over the cephalic vein. Plasma concentrations of lidocaine were analyzed with a high-performance liquid chromatography assay. Results-Two cats had minimal transdermal absorption of lidocaine, with lidocaine concentrations below the sensitivity of the assay at all but 1 or 2 time points. In the other 4 cats, the median maximum plasma concentration was 149.5 ng/ml, the median time to maximum plasma concentration was 2 hours, and the median area under the concentration versus time curve from zero to infinity was 1014.5 ng.h/ml.


CONCLUSIONS
Maximum plasma concentrations of lidocaine remained substantially below toxic plasma concentrations for cats. On the basis of these data, topical administration of a liposome-encapsulated lidocaine formulation at a dose of 15 mg/kg appears to be safe for use in healthy adult cats.
Fransson
Boel A
BA
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164, USA.
Peck
Kenneth E
KE
Smith
Jennifer K
JK
Anthony
Janice A
JA
Mealey
Katrina L
KL
D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D019540:Area Under Curve; D002415:Cats / Q000378:metabolism*; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D008081:Liposomes / Q000008:administration & dosage*
D008081:Liposomes; D008012:Lidocaine