[Non-alcoholic steatohepatitis].
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease that occurs in patients with no significant alcohol consumption; it is not histologically different from alcoholic hepatitis because it presents macrovesicular steatosis, hepatocellular necrosis, mixed inflammatory infiltrate, and various stages of fibrosis in addition Mallory bodies in some patients. Some authors have even described NASH as a benign disease; however, it is presently considered a potentially serious disease that may evolve into liver cirrhosis and probably, liver cancer. It is more often related to female sex, obesity, and dyslipidemia, although it may be present in other population groups and associated with other factors. Its origin may be multifactorial, including insulin resistance, protein glycation, oxidative stress, and others. The disease may be asymptomatic and found in routine physical exams when the patient shows increased aminotransferases with no other explanation. At present the only specific diagnosis procedure is liver biopsy. The sole available current treatment is body weight control, normalizing glucose and lipid blood levels, as well as the administration of some medication, as illustrated in the subsequent article.
Alvarez-Martínez
Héctor
H
Hospital Regional Presidente Juárez, ISSSTE, Oaxaca, Oax. heloy_57@yahoo.com.mx
Pérez-Campos
Eduardo
E
D000111:Acetylcysteine / Q000008:administration & dosage / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D001622:Betaine / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D048909:Diabetes Complications; D005234:Fatty Liver / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000628:therapy; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use; D006505:Hepatitis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007333:Insulin Resistance; D008082:Lipotropic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000628:therapy; D010865:Pilot Projects; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use; D015431:Weight Loss
D000975:Antioxidants; D002756:Cholagogues and Choleretics; D016166:Free Radical Scavengers; D008082:Lipotropic Agents; D014810:Vitamin E; D001622:Betaine; D014580:Ursodeoxycholic Acid; D000111:Acetylcysteine