[A clinical research on oxymatrine for the treatment of chronic hepatitis B].
OBJECTIVE
To investigate the clinical effect of oxymatrine on chronic viral hepatitis B and to look for new methods for treating hepatitis B.


METHODS
Multi-center, controlled study was used. In this study, 196 patients were allocated to oxymatrine, oxymatrine with Ara-AMP, IFN-a1b, and glucose groups to observe ALT, AST and viral marker changes.


RESULTS
At the end of treatment, the rate of normal ALT, the negative rate of HBV DNA and HBeAg, and the positive rate of HBeAb were similar in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups. It was higher than that of glucose group. After 12 months follow up, the total effective rate is 40.8%, 60.8% and 43.1% in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups, respectively.


CONCLUSIONS
Oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b are effective to treat hepatitis B with a good negative rate of HBV DNA and HBeAg and positive rate of HBeAb.
Yu
Yan Yan
YY
Department of Infectious Diseases, First Teaching Hospital, Peking University, Beijing 100034, China.
Wang
Qin Huan
QH
Zhu
Li Min
LM
Zhang
Qing Bo
QB
Xu
Dao Zhen
DZ
Guo
Yan Bin
YB
Wang
Chao Quan
CQ
Guo
Shu Hua
SH
Zhou
Xia Qiu
XQ
Zhang
Ling Xia
LX
D000293:Adolescent; D000328:Adult; D000470:Alkaloids / Q000009:adverse effects / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011807:Quinolizines; D000093842:Matrines
D000470:Alkaloids; D000998:Antiviral Agents; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines