title: Phospholipid scramblase, a new effector of FcepsilonRI signaling in mast cells.
abstract: The signaling network of the high-affinity receptor for IgE in mast cells involves tyrosine phosphorylation of a number of proteins. Here we report evidence that phospholipid scramblase, a protein involved in the distribution of phospholipids between the two leaflets of the plasma membrane, is a target for tyrosine kinases in this signal. The implication of this observation is briefly discussed.
authors.affiliation: INSERM U 485, Institut Pasteur, 25 rue du Dr. Roux, 75015, Paris, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Pastorelli
authors.forename: Joël
authors.initials: J
authors.lastname: Veiga
authors.forename: Nicolas
authors.initials: N
authors.lastname: Charles
authors.forename: Emilie
authors.initials: E
authors.lastname: Voignier
authors.forename: Hélène
authors.initials: H
authors.lastname: Moussu
authors.forename: Renato
authors.initials: R
authors.lastname: Monteiro
authors.forename: Marc
authors.initials: M
authors.lastname: Benhamou
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D008407:Mast Cells / Q000201:enzymology* / Q000276:immunology; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D049294:Phospholipid Transfer Proteins; D010750:Phosphoproteins / Q000032:analysis; D017434:Protein Structure, Tertiary; D051381:Rats; D017455:Receptors, IgE / Q000378:metabolism*; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D049294:Phospholipid Transfer Proteins; D010750:Phosphoproteins; D017455:Receptors, IgE; D014443:Tyrosine