[Neurophysiological analysis of the effects of antihypoxic versus psychotropic agents].
The Fourie EEG spectral analysis of thr sensomotor cortex and dorsal hypocampus in freely moving rats could reveal the common pharmacological EEG effects of different antihypoxic agents (gutimin, amtizole, emoxipine, and 3-OPK). All the agents decreased the total EEG power (they all reduced the absolute power in all frequency bands) and simultaneously enhanced (2 relative power. The former suggests that there was a decrease in the energetic level of bioelectric fluctuations, which may indicate that the brain reduces its energetic functioning level. The latter means that antihypoxic drugs activate the central nervous system. This effect may normalize EEG activity during hypoxic conditions, which causes the enhancement of slow-wave activity and reduces fast EEG activity. The pharmacological EEG effects of different groups of psychotropic drugs (nootropic drugs, psychostimulants, antidepressants, benzodiazepine tranquilizers, etc.) versus antihypoxants are discussed.
Krapivin
S V
SV
Malyshev
A Iu
AIu
Kharitonov
A V
AV
Ermishina
O S
OS
Shubin
S N
SN
Luk'ianova
L D
LD
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D005583:Fourier Analysis; D006164:Guanylthiourea / Q000494:pharmacology* / Q000627:therapeutic use; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013830:Thiadiazoles / Q000494:pharmacology* / Q000627:therapeutic use
D010847:Picolines; D011619:Psychotropic Drugs; D013830:Thiadiazoles; C044365:amtizol; D006164:Guanylthiourea; C009820:6-methyl-2-ethyl-3-hydroxypyridine