A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles.
Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation.
Bilia
Anna Rita
AR
Department of Pharmaceutical Sciences, University of Florence, via Gino Capponi 9, 50121 Firenze, Italy.
Bergonzi
M Camilla
MC
Vincieri
Francesco F
FF
Lo Nostro
Pierandrea
P
Morris
Gareth A
GA
D000465:Algorithms; D037621:Artemisinins / Q000737:chemistry*; D001205:Ascorbic Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004058:Diffusion; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D009502:Neutrons; D012542:Scattering, Radiation; D012717:Sesquiterpenes / Q000737:chemistry*; D012995:Solubility
D037621:Artemisinins; D008823:Micelles; D012717:Sesquiterpenes; C470083:octanoyl-6-O-ascorbic acid; C031327:artemisinin; D001205:Ascorbic Acid