Molecular mechanism of autoimmune hearing loss.
Molecules considered as autoantigens in autoimmune sensorineural hearing loss and Meniere's diseases are type II collagens, type IX collagens, 30 kD proteins of inner ear membranes, laminin, 68 kD proteins of inner ear, PO protein, Raf I protein and beta-tubulin are reviewed in relation to molecular mechanisms of autoimmune injury of inner ear resulting in hearing loss.
Yoo
T J
TJ
Department of Medicine, University of Tennessee Health Science Center, Memphis 38163, USA. tyoo@utmem.edu
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Kwon
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000032:analysis; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology*; D003094:Collagen / Q000276:immunology; D007758:Ear, Inner / Q000276:immunology; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology; D006319:Hearing Loss, Sensorineural / Q000276:immunology*; D006801:Humans; D007797:Laminin / Q000276:immunology; D008575:Meniere Disease / Q000276:immunology*; D018993:Myelin P0 Protein / Q000276:immunology; D011506:Proteins / Q000276:immunology; D019908:Proto-Oncogene Proteins c-raf / Q000276:immunology; D014404:Tubulin / Q000276:immunology
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001324:Autoantigens; D018840:HSP70 Heat-Shock Proteins; D007797:Laminin; D018993:Myelin P0 Protein; D011506:Proteins; D014404:Tubulin; D003094:Collagen; D019908:Proto-Oncogene Proteins c-raf