title: N-substituted hydroxyureas as urease inhibitors.
abstract: In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl- (10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.
authors.affiliation: Department of Biotechnology, Faculty of Engineering, Kansai Univeristy, Suita, Osaka, Japan. uesato@ipcku.kansai-u.ac.jp
authors.forename: Shinichi
authors.initials: S
authors.lastname: Uesato
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Nishino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuwajima
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000737:chemistry*; D007887:Fabaceae / Q000201:enzymology; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D014510:Urease; D006918:Hydroxyurea