Exercise-induced central retinal vein thrombosis: possible involvement of hemorheological disturbances. A case report.
Exercise-induced impairment in blood fluidity has been supposed to increase cardiovascular risk but there is no data to support this hypothesis. We report the case of a 50 yr old marathon runner who underwent a central retinal vein thrombosis after a marathon run. We investigated his rheological response to exercise compared to control subjects of previous studies. During a standardized sub-maximal exercise-test, the increase in blood viscosity (+28%) and hematocrit (+25%) exceeded the control range but the most striking differences were found for red cell aggregation (Myrenne +47%) and disaggregation thresholds (Affibio +37%). Although some of this post-exercise hyperviscosity pattern may be due to the previous vascular event, these findings may also support the hypothesis of a role for hemorheological alterations during exercise in the pathogenesis of this marathon-induced retinal thrombosis, and indicate that after such an event hemorheological adaptation to exercise remains markedly disturbed.
Gaudard
A
A
Laboratoire de Pharmacocinétique Clinique, Faculté de Pharmacie, Université Montpellier I, France.
Varlet-Marie
E
E
Monnier
J F
JF
Janbon
Ch
Ch
Quéré
I
I
Bressolle
F
F
Brun
J-F
JF
D001809:Blood Viscosity; D004903:Erythrocyte Aggregation; D015444:Exercise / Q000502:physiology*; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012420:Running / Q000293:injuries