title: Resolution of psoriasis following allogeneic bone marrow transplantation for chronic myelogenous leukemia: case report and review of the literature.
abstract: We describe a case of a 49-year-old man with chronic myelogenous leukemia (CML) whose coincidental psoriasis resolved following allogeneic bone marrow transplantation (BMT). The patient had suffered from psoriasis for 20 years and was treated with corticosteroid ointment. He was diagnosed as having CML in 1998, and his psoriasis deteriorated following interferon therapy. In March 1999, he received a BMT from an HLA-identical sister after undergoing a conditioning regimen involving busulfan, cytosine arabinoside, and cyclophosphamide. Prophylaxis of acute graft-versus-host disease was done using short-term methotrexate and cyclosporin A. His psoriasis improved immediately and disappeared completely on day 70 after BMT. For 2.5 years, his CML remains in remission and he is free of psoriasis without undergoing immunosuppressive therapy. This case suggests the potential benefits of the treatment of immune-mediated diseases with allogeneic BMT.
authors.affiliation: First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan. heiwak@med.yokohama-cu.ac.jp
authors.forename: Heiwa
authors.initials: H
authors.lastname: Kanamori
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaji
authors.forename: Katsumichi
authors.initials: K
authors.lastname: Fujimaki
authors.forename: Naoto
authors.initials: N
authors.lastname: Tomita
authors.forename: Shin
authors.initials: S
authors.lastname: Fujisawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000628:therapy*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications / Q000628:therapy*; D012074:Remission Induction; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents