title: Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin.
abstract: BACKGROUND
  We encountered on seven malignant hepatocellular tumors developing in older children and adolescents.
  
  
  RESULTS
  These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis.
  
  
  CONCLUSIONS
  We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions.
authors.affiliation: The Children's Memorial Health Institute, Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Prokurat
authors.forename: Przemysław
authors.initials: P
authors.lastname: Kluge
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kościesza
authors.forename: Danuta
authors.initials: D
authors.lastname: Perek
authors.forename: Andreas
authors.initials: A
authors.lastname: Kappeler
authors.forename: Arthur
authors.initials: A
authors.lastname: Zimmermann
mesh_terms: D000293:Adolescent; D002295:Carcinoma, Transitional Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D002648:Child; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D018197:Hepatoblastoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D014057:Tomography, X-Ray Computed; D015534:Trans-Activators / Q000378:metabolism*; D051176:beta Catenin
chemical_list: C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin