title: [Successful treatment of hairy cell leukemia prolymphocytic variant with 2'-deoxycoformycin].
abstract: The hairy cell leukemia prolymphocytic variant, a subtype of hairy cell leukemia, is an extremely rare disease, especially in Japan. We report a case in which treatment with 2'-deoxycoformycin (DCF) improved the clinical features of the disease. The patient, a 70-year-old female, was first treated with 2-chlorodeoxyadenosine, but showed only transient improvement in the hematological findings. DCF was then administered every week. Following the start of this treatment, the leukemia cell count rapidly decreased and the platelet count simultaneously increased. This effect of DCF has so far been long term. More clinical studies are needed to confirm the therapeutic value of DCF.
authors.affiliation: Department of Hematology and Oncology, Osaka University School of Medicine.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nagai
authors.forename: Tohru
authors.initials: T
authors.lastname: Izumi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Noborio
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takatoku
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Machii
authors.forename: Norio
authors.initials: N
authors.lastname: Komatsu
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy*; D015463:Leukemia, Prolymphocytic / Q000188:drug therapy*; D015649:Pentostatin / Q000627:therapeutic use*
chemical_list: D000903:Antibiotics, Antineoplastic; D015649:Pentostatin