title: A new synthesis of Neu5Ac from D-glucono-delta-lactone.
abstract: A new route to Neu5Ac methyl ester (23) with a readily available sugar D-glucono-delta-lactone as starting material has been developed. A diastereoselective propargylation of alpha-acetamino aldehyde and a subsequent KMnO(4) oxidation of the terminal alkyne served as the key steps.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, China.
authors.forename: Ke-Gang
authors.initials: KG
authors.lastname: Liu
authors.forename: Shi
authors.initials: S
authors.lastname: Yan
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Wu
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Yao