title: Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid.
abstract: L-731,988 inhibits human immunodeficiency virus (HIV) replication through integrase. In this study, approximately 600 nM L-731,988 inhibited the replication of 12 HIV type 1 isolates from multiple clades, including primary isolates and cloned viruses. These data suggest that diketo acids or their derivatives may prove useful on a worldwide basis in treating HIV infection.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California, Irvine 92697, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Reinke
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Lee
authors.forename: W Edward
authors.initials: WE
authors.lastname: Robinson
mesh_terms: D000090:Acetoacetates / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D019427:HIV Integrase / Q000187:drug effects / Q000235:genetics; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D017422:Sequence Analysis, DNA; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000090:Acetoacetates; D019428:HIV Integrase Inhibitors; C403886:L 731988; D011758:Pyrroles; D019427:HIV Integrase