title: Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.
abstract: Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.
authors.affiliation: Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. tallen2@partners.org
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
authors.forename: Peicheng
authors.initials: P
authors.lastname: Jing
authors.forename: Briana
authors.initials: B
authors.lastname: Calore
authors.forename: Helen
authors.initials: H
authors.lastname: Horton
authors.forename: David H
authors.initials: DH
authors.lastname: O'Connor
authors.forename: Tomas
authors.initials: T
authors.lastname: Hanke
authors.forename: Marian
authors.initials: M
authors.lastname: Piekarczyk
authors.forename: Richard
authors.initials: R
authors.lastname: Ruddersdorf
authors.forename: Bianca R
authors.initials: BR
authors.lastname: Mothé
authors.forename: Carol
authors.initials: C
authors.lastname: Emerson
authors.forename: Nancy
authors.initials: N
authors.lastname: Wilson
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lifson
authors.forename: Igor M
authors.initials: IM
authors.lastname: Belyakov
authors.forename: Jay A
authors.initials: JA
authors.lastname: Berzofsky
authors.forename: Chenxi
authors.initials: C
authors.lastname: Wang
authors.forename: David B
authors.initials: DB
authors.lastname: Allison
authors.forename: David C
authors.initials: DC
authors.lastname: Montefiori
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Desrosiers
authors.forename: Steven
authors.initials: S
authors.lastname: Wolinsky
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Kunstman
authors.forename: John D
authors.initials: JD
authors.lastname: Altman
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: McMichael
authors.forename: David I
authors.initials: DI
authors.lastname: Watkins
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002455:Cell Division; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology*; D008253:Macaca mulatta; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination
chemical_list: D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015395:Histocompatibility Antigens Class I; D016056:Immunodominant Epitopes; C110764:Mamu-A 01 antigen