Mast cells: a cellular link between autoantibodies and inflammatory arthritis.
Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.
Lee
David M
DM
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Friend
Daniel S
DS
Gurish
Michael F
MF
Benoist
Christophe
C
Mathis
Diane
D
Brenner
Michael B
MB
D000818:Animals; D001168:Arthritis / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000276:immunology*; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D015550:Cell Degranulation; D007596:Joints / Q000276:immunology* / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000276:immunology* / Q000637:transplantation; D051379:Mice; D008810:Mice, Inbred C57BL
D001323:Autoantibodies