[Correlation between sex hormone receptors in normal and cancerous target tissues].
According to the classic model of regulation of sex hormone receptors biosynthesis in target tissues, oestrogen stimulates and progesterone inhibits biosynthesis in both receptors. One of the consequences of this model is a direct correlation between oestrogen (ER) and progesterone receptors (PR) in target tissues. Here we investigate a correlation between ER and PR in calf endometrium and breast cancer (BC) tissues of women. A direct correlation was found between receptors in the calf endometrium (r = +0.70; p < 0.01). There were three variants of BC tissues: without correlation, with positive correlation (r = +0.49; p < 0.01), and with non-linear negative correlation between ER and PR. The last variant of samples were detected exclusively in patients operated in spring and fall. The non-linear negative correlation between ER and PR in BC tissues in spring and fall may indicate disregulation of sex hormone receptors biosynthesis under the influence of external factors.
Borisenkov
M F
MF
Institute of Physiology of the Komi Research Centre, Ural Division of the Russian Acad. Sci., 167982 Syktyvkar, 50 Pervomaiskaya St., Russia.
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D002417:Cattle; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D011959:Receptors, Estradiol / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000096:biosynthesis*; D012621:Seasons
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone