title: Experimental eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) from mice colonies using ivermectin.
abstract: A spray administration of ivermectin was evaluated for the treatment of pinworm infection in mice. In this study, a spray of 0.1% ivermectin injectable solution over the entire cage once a week, for three consecutive weeks (one cycle treatment), was effective in eradicating both Syphacia obvelata and Aspiculuris tetraptera from mice under experimental conditions. In addition, no acute toxicity was observed in 105 mothers or 687 neonates treated with ivermectin, indicating that ivermectin does not affect murine reproduction. Finally, we attempted to eradicate pinworms from infected mice in our institute using this method. Two cycles of treatment were administered, with a two-week pause between cycles, resulting in complete eradication for at least one year. Treating mouse colonies with spray ivermectin is inexpensive, safe, requires very little labor and is very effective at eradicating pinworms from mice.
authors.affiliation: Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Teruko
authors.initials: T
authors.lastname: Sueta
authors.forename: Ichiro
authors.initials: I
authors.lastname: Miyoshi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okamura
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kasai
mesh_terms: D000818:Animals; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D010123:Oxyuriasis / Q000188:drug therapy* / Q000662:veterinary*; D010124:Oxyuroidea; D012376:Rodent Diseases / Q000188:drug therapy*
chemical_list: D007559:Ivermectin