title: Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes.
abstract: The genes encoding human leukocyte antigens (HLA) have shown to be associated with cervical neoplasia. To obtain reliable data on HLA associations with cervical tumors, the study should be performed within a strictly defined cohort. To investigate the population attributable risk of cervical cancer associated with the HLA class II haplotypes DR15 and DQ6 (DQA1*0102 and DQB1*0602), we performed a nested case-control study of 85 women who developed invasive cervical cancer and 120 healthy women from a population-based cohort of Swedish women. The relative risks of cervical cancer among DR15 and DQ6-positive women were 3.73 [confidence interval (CI): 1.8-7.4] and 4.33 (CI: 2.1-8.5), corresponding to population attributable proportions of 27.9% and 30.8%, respectively. A susceptibility locus in the HLA class II region is involved in a substantial fraction of the etiology of cervical cancer.
authors.affiliation: Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.
authors.forename: Mehran
authors.initials: M
authors.lastname: Ghaderi
authors.forename: Keng-Ling
authors.initials: KL
authors.lastname: Wallin
authors.forename: Fredrik
authors.initials: F
authors.lastname: Wiklund
authors.forename: Liene Nikitina
authors.initials: LN
authors.lastname: Zake
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Per
authors.initials: P
authors.lastname: Lenner
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
authors.forename: Carani B
authors.initials: CB
authors.lastname: Sanjeevi
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D015331:Cohort Studies; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D006683:HLA-DQ Antigens; C063831:HLA-DQ6 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen