title: Eliminating spurious lipid sidebands in 1H MRS of breast lesions.
abstract: Detecting metabolites in breast lesions by in vivo (1)H MR spectroscopy can be difficult due to the abundance of mobile lipids in the breast which can produce spurious sidebands that interfere with the metabolite signals. Two-dimensional J-resolved spectroscopy has been demonstrated in the brain as a means to eliminate these artifacts from a large water signal; coherent sidebands are resolved at their natural frequencies, leaving the noncoupled metabolite resonances in the zero-frequency trace of the 2D spectrum. This work demonstrates that using the zero-frequency trace-or equivalently the average of spectra acquired with different echo times-can be used to separate noncoupled metabolite signals from the lipid-induced sidebands. This technique is demonstrated with simulations, phantom studies, and in several breast lesions. Compared to the conventional approach using a single echo time, echo time averaging provides increased sensitivity for the study of small and irregularly shaped lesions.
authors.affiliation: Center for Magnetic Resonance Research, University of Minnesota School of Medicine, Minneapolis 55455, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Bolan
authors.forename: Lance
authors.initials: L
authors.lastname: DelaBarre
authors.forename: Eva H
authors.initials: EH
authors.lastname: Baker
authors.forename: Hellmut
authors.initials: H
authors.lastname: Merkle
authors.forename: Lenore I
authors.initials: LI
authors.lastname: Everson
authors.forename: Douglas
authors.initials: D
authors.lastname: Yee
authors.forename: Michael
authors.initials: M
authors.lastname: Garwood
mesh_terms: D016477:Artifacts; D001940:Breast / Q000737:chemistry*; D001943:Breast Neoplasms / Q000737:chemistry*; D002794:Choline / Q000032:analysis; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D008055:Lipids; D002794:Choline