Gastric emptying in myotonic dystrophic patients.
BACKGROUND
Myotonic dystrophy is often associated with digestive symptoms that can precede the clinical appearance of skeletal muscle involvement. Although motility disorders may be observed in these patients at any level of the gastrointestinal tract, upper gastrointestinal symptoms have up to now usually been considered to be due to oesophageal rather than gastric dysmotility.


OBJECTIVE
To evaluate: a) gastric emptying in myotonic dystrophic patients without dyspeptic symptoms, and b) relationship between gastric emptying and severity and duration of the disease.


METHODS
Gastric emptying was evaluated in 11 non-dyspeptic dystrophic patients and in 22 healthy volunteers by means of computerised ultrasound scan, assessing the variation in the antral area over time after ingestion of a meal.


RESULTS
The final emptying time was higher in patients than in healthy volunteers (373' +/- 35' vs 270' +/- 47'; p < 0.001). Basal and maximal post-prandial antral areas were similar in the two groups. There was a significant correlation between gastric emptying and the duration of the disease (rs = 0.62; p = 0.04). No relationship was found between gastric emptying and severity of the disease.


CONCLUSIONS
Gastric emptying may be abnormally delayed in myotonic dystrophy patients, even in absence of dyspeptic symptoms. This delay is correlated with duration but not with severity of the disease. However there is no difference in either basal or maximal postprandial antral areas between myotonic dystrophy patients and healthy volunteers.
Bellini
M
M
mbellini@int.med.unipi.it
Alduini
P
P
Costa
F
F
Tosetti
C
C
Pasquali
L
L
Pucciani
F
F
Tornar
A
A
Mammini
C
C
Siciliano
G
G
Maltinti
G
G
Marchi
S
S
D000328:Adult; D004415:Dyspepsia / Q000150:complications / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000150:complications / Q000503:physiopathology*; D011706:Pyloric Antrum / Q000503:physiopathology; D012720:Severity of Illness Index; D013997:Time Factors