title: [Painful edema of the feet revealing ankylosing spondylitis].
abstract: BACKGROUND
  Painful peripheral oligoarthritis can reveal ankylosing spondylitis. In some instances, an acral pitting edema can be the sign of this affection.
  
  
  METHODS
  A 39-year-old man, with no significant previous medical history, consulted in a dermatology department for acral pain and edema of both feet, which were exacerbated during the second part of the night. On examination, he had a pitting edema and a livedo of the distal part of the feet. Biological investigations revealed an inflammatory syndrome and the presence of the histocompatibility HLA-B27 antigen. Bone scintigraphy revealed distal hyperfixation on both feet. Diagnosis of ankylosing spondylitis was established.
  
  
  CONCLUSIONS
  Late-onset ankylosing spondylitis, which appears in subjects older than 35 years, can manifest as peripheral arthritis with systemic signs, often in the absence of involvement of the axial skeleton. Peripheral pitting edema of lower limbs can be the presenting sign. Since cutaneous involvement can be the presenting sign, dermatologists should be aware of this entity.
authors.affiliation: Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Marquart-Elbaz
authors.forename: D
authors.initials: D
authors.lastname: Lipsker
authors.forename: J
authors.initials: J
authors.lastname: Sibilia
authors.forename: M
authors.initials: M
authors.lastname: Faivre
authors.forename: E
authors.initials: E
authors.lastname: Grosshans
authors.forename: B
authors.initials: B
authors.lastname: Cribier
mesh_terms: D000328:Adult; D017668:Age of Onset; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis; D003937:Diagnosis, Differential; D004487:Edema / Q000209:etiology*; D004890:Erythema / Q000209:etiology*; D005534:Foot Diseases / Q000209:etiology*; D015796:HLA-B27 Antigen / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D006945:Hyperhidrosis / Q000209:etiology*; D008297:Male; D010146:Pain / Q000209:etiology*; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015796:HLA-B27 Antigen; D002097:C-Reactive Protein