The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties.
BACKGROUND
The evaluation of organized mammographic service screening programs is a major challenge in public health. In particular, there is a need to evaluate the effect of the screening program on the mortality of breast carcinoma, uncontaminated in the screening epoch by mortality from 1) cases diagnosed in the prescreening period and 2) cases diagnosed among unscreened women (i.e., nonattenders) after the initiation of organized screening.


METHODS
In the current study, the authors ascertained breast carcinoma deaths in the prescreening and screening epochs in 7 Swedish counties from tumors diagnosed in these epochs and in the age group 40-69 years in 6 counties and 50-69 years in 1 county. Data regarding deaths were obtained from the Uppsala Regional Oncologic Center in conjunction with the National Cause of Death Register. The total number of women in the eligible age range living in each county was obtained from the annual population data of Statistics Sweden. Detailed screening data were provided by the screening centers in the seven counties, including the number of invited, the number attended, and whether each individual breast carcinoma case was exposed (screen-detected and interval cases combined) or unexposed (not-invited or nonattenders) to mammographic screening. There were 2044 breast carcinoma deaths from 14,092 incident tumors diagnosed in the prescreening and screening epochs, and the total number of person-years was 7.5 million. Data were analyzed using Poisson regression with corrections for self-selection bias and lead-time bias when appropriate.


RESULTS
The mortality reduction for breast carcinoma in all 7 counties combined for women actually exposed to screening compared with the prescreening period was 44% (relative risk [RR] = 0.56; 95% confidence interval [95% CI], 0.50-0.62). When all incident tumors were considered, both those exposed and those unexposed to screening combined, counties with > 10 years of screening were found to demonstrate a significant 32% mortality reduction (RR = 0.68; 95% CI, 0.60-0.77) and counties with < or = 10 years of screening showed a significant 18% reduction in breast carcinoma mortality (RR = 0.82; 95% CI, 0.72-0.94) for the screening epoch compared with the prescreening epoch. Within the screening epoch, after adjustment for self-selection bias, a 39% mortality reduction (RR = 0.61; 95%CI, 0.55-0.68) was observed in association with invitation to screening.


CONCLUSIONS
Organized service screening in 7 Swedish counties, covering approximately 33% of the population of Sweden, resulted in a 40-45% reduction in breast carcinoma mortality among women actually screened. The policy of offering screening is associated with a mortality reduction in breast carcinoma of 30% in the invited population, exposed and unexposed combined. The results of the current study indicate that the majority of the breast carcinoma mortality reduction is indeed due to the screening.
Duffy
Stephen W
SW
Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX, United Kingdom. stephen.duffy@cancer.org
Tabár
Laszlo
L
Chen
Hsiu-Hsi
HH
Holmqvist
Marit
M
Yen
Ming-Fang
MF
Abdsalah
Shahim
S
Epstein
Birgitta
B
Frodis
Ewa
E
Ljungberg
Eva
E
Hedborg-Melander
Christina
C
Sundbom
Ann
A
Tholin
Maria
M
Wiege
Mika
M
Akerlund
Anders
A
Wu
Hui-Min
HM
Tung
Tao-Shin
TS
Chiu
Yueh-Hsia
YH
Chiu
Chen-Pu
CP
Huang
Chih-Chung
CC
Smith
Robert A
RA
Rosén
Måns
M
Stenbeck
Magnus
M
Holmberg
Lars
L
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors