[Effect of a nibentan derivative LKhT53-91 on the heart electrophysiological parameters].
The compound LKhT5391 (a derivative of nibentan) affects the electrophysiological cardiac parameters to a lower extent than does nibentan. Administered in an effective antiarrhythmogenic dose (comparable with the effective dose of nibentan), LKhT5391 produces a less pronounced and shorter negative chronotropic action than does nibentan. The negative dromotropic effect of the compound studied is manifested only in the atrioventricular node, while not influencing conductivity through the atria and ventricles.
Kotliarov
A A
AA
Department of Clinical Therapy, Mordvinian State University, ul. Ul'yanova 26, Saransk, Mordvinia, 430003 Russia.
Napalkova
S M
SM
Babin
V V
VV
Skachilova
S Ia
SIa
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001216:Asparagine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001283:Atrioventricular Node / Q000187:drug effects / Q000502:physiology; D001549:Benzamides / Q000494:pharmacology*; D002415:Cats; D003864:Depression, Chemical; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D008297:Male
D000889:Anti-Arrhythmia Agents; D001549:Benzamides; D001216:Asparagine; C105049:nibentan