title: Intracerebral hemorrhage triggers interleukin-6 and interleukin-10 release in blood.
abstract: OBJECTIVE
  Acute brain insult can cause systemic anti-inflammatory response, including anti-inflammatory cytokine release. The goal of this study was to determine the serum level of interleukin-6, interleukin-10, and interleukin-13 in patients with intracerebral hemorrhage and to correlate cytokine concentrations with stroke severity.
  
  
  METHODS
  Thirty patients with intraparenchymal hemorrhage and 16 control subjects were included. Serum samples were collected on the second day of hemorrhagic stroke. Cytokine level was measured with the enzyme-linked immunosorbent assay method.
  
  
  RESULTS
  Increased serum levels of interleukin-6 and interleukin-10 were detected in stroke patients. Interleukin-6 and interleukin-10 levels were significantly correlated with Glasgow Coma Scale score. In addition, interleukin-6 level correlated with blood volume and mass effect.
  
  
  CONCLUSIONS
  Intracerebral hemorrhage is associated with systemic release of anti-inflammatory cytokines.
authors.affiliation: Stroke Unit, Department of Neurology, and Second Department of Cardiology, Collegium Medicum, Jagiellonian University, Krakow, Poland. Dziedzic@neuro.cm-uj.krakow.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziedzic
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Bartus
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Klimkowicz
authors.forename: Maciej
authors.initials: M
authors.lastname: Motyl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Slowik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szczudlik
mesh_terms: D015415:Biomarkers / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005260:Female; D015600:Glasgow Coma Scale; D006406:Hematoma / Q000000981:diagnostic imaging; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D018793:Interleukin-13 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D020521:Stroke / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D018793:Interleukin-13; D015850:Interleukin-6; D016753:Interleukin-10