[Lipid peroxidation in the rats striatum during stress after cortisol administration].
Lipid peroxidation in the rat striatum under stress after cortisole injection was investigated. Three days cortisole injections (25 mg/kg every day) do not affect the level of lipid peroxidation products 6 days after termination of the hormone injection. However, in these periods, cortisole injected rats had a more significant response of lipid peroxidation to stress than the control animals (decrease of intermediate products and increase of Shift bases). Thus, the hormone injection induced a long-term changes in so important a regulatory system of the organisms as the lipid peroxidation, causing sensitization of its response to stress.
Flerov
M A
MA
I.P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, 199034, Nab. Makarova, 6, St. Petersburg.
Gerasimova
I A
IA
Rakitskaia
V V
VV
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D004597:Electroshock; D006854:Hydrocortisone / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology*
D006854:Hydrocortisone