title: Signalling shortcuts: cell-surface receptors in the nucleus?
abstract: Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there and what function do they serve in this location? Recent advances have provided tantalizing hints to the answers to these questions, and hold the key to identifying a new mode of signal transduction.
authors.affiliation: Department of Pathology, 713 Scaife, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. wellsa@msx.upmc.edu
authors.forename: Alan
authors.initials: A
authors.lastname: Wells
authors.forename: Ulrich
authors.initials: U
authors.lastname: Marti
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D011956:Receptors, Cell Surface; D066246:ErbB Receptors