title: A simple technique for the determination of salivary gland hypofunction.
abstract: OBJECTIVE
  Present volumetric or gravimetric techniques for measuring saliva output are often cumbersome and, therefore, not generally used. In the present study, a simple approach to study the weight loss of a standard hard sugar candy after 3 minutes of passive incubation between tongue dorsum and palate was tested.
  
  
  METHODS
  Subjects (n = 59), 27 of whom had a subjective complaint of dry mouth and the rest who were healthy control subjects, were tested with this procedure, together with gravimetric measurements of stimulated and unstimulated saliva output from various glands (parotid, submandibular, and sublingual). Correlations between a decrease in candy weight and salivary flow rate were determined for the 2 groups of subjects, taken separately, as well as for the entire subject population, by using the Pearson product moment correlation.
  
  
  RESULTS
  In most cases, highly significant associations were found, particularly when comparing candy weight loss with stimulated parotid and submandibular and sublingual saliva. Data were submitted to dichotomous analysis and divided according to salivary flow rate by using a cutoff 0.23 g for candy loss; the sensitivity, specificity, and positive predictive values were 92%, 85%, and 82%, respectively.
  
  
  CONCLUSIONS
  The candy weight-loss test is a simple, rapid measure of salivary hypofunction, which correlates with saliva output and reports of subjective dry mouth.
authors.affiliation: Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
authors.forename: Andy
authors.initials: A
authors.lastname: Wolff
authors.forename: Dan
authors.initials: D
authors.lastname: Herscovici
authors.forename: Mel
authors.initials: M
authors.lastname: Rosenberg
mesh_terms: D002182:Candy; D006801:Humans; D010159:Palate; D010306:Parotid Gland / Q000378:metabolism; D011237:Predictive Value of Tests; D012463:Saliva / Q000378:metabolism; D012636:Secretory Rate / Q000502:physiology; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013361:Sublingual Gland / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism; D013997:Time Factors; D014059:Tongue; D014987:Xerostomia / Q000175:diagnosis*