[Relationship between insulin resistance and clustering of risk factors of cerebrovascular disease].
OBJECTIVE
To study the relationship between insulin resistance and clustering of risk factors of cerebrovascular disease.


METHODS
The serum concentrations of fasting glucose, insulin, lipids, the activities of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1), and the level of blood pressure were measured in 159 patients with stroke and 40 healthy control subjects.


RESULTS
All subjects were divided into 4 groups in the light of number of risk factors of cerebrovascular disease. As the number of risk factors increased, the insulin sensitivity index (ISI) in four groups gradually decreased. The ISI in the patients with cerebrovascular disease was negatively associated with increased levels of SBP, DBP, TG, APOB, and PAI-1 activity (P < 0.01) and positively with decreased level of HDL (P < 0.01).


CONCLUSIONS
Insulin resistance is associated with clustering of risk factors of cerebrovascular disease, the more resistant, the more clustered.
Du
X P
XP
Department of Neurology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Xia
J
J
Yang
Q D
QD
Xu
H W
HW
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000097:blood*; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood; D012307:Risk Factors; D020521:Stroke / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D015849:Plasminogen Inactivators