Comparison of subjective and objective measures in recurrently wheezy infants.
OBJECTIVE
The aim of this study was to compare subjective measures (overall health assessment both by the study physician and the child's mother) with objective measurements of forced expiratory volumes (FEV(t)) and maximal flow at functional residual capacity V(max)FRC) in recurrently wheezy infants.


METHODS
Sixteen wheezy infants (12 boys) aged 8-26 months were studied. A clinical assessment at visit 1 was followed by the run-in period during which day- and nighttime asthma symptom scores were obtained. The actual study period consisted of 2 visits when patient's lung function was assessed. The first of which was during an acute exacerbation (visit 2), while the second was when the infant was asymptomatic (visit 3). FEV(t) were obtained by the raised volume rapid thoracic compression technique (RVRTC) and V(max)FRC by the tidal volume rapid thoracic compression technique (TVRTC).


RESULTS
Mean FEV(t) but not mean V(max)FRC were significantly lower at visit 2 compared to visit 3 (FEV(0.5): p = 0.005, and FEV(0.75): p = 0.002; V(max)FRC: p = 0.15) and correlated well with overall health assessment by the study physician (FEV(0.5): r = 0.82, and FEV(0.75): r = 0.84), but not with the overall health assessment by the mother.


CONCLUSIONS
We have shown in the present study that objective measurements of FEV(t) from a raised lung volume correlate well with the overall health assessment by the study physician; this was in contrast to measurements of V(max)FRC in the tidal volume range. We therefore conclude that the RVRTC technique is a feasible method to assess and monitor obstructive lung disease in infancy.
Wildhaber
Johannes H
JH
Swiss Paediatric Respiratory Physiology Research Group, Department of Respiratory Medicine, University Children's Hospital, Zürich, Switzerland. johannes.wildhaber@kispi.unizh.ch
Dore
Nigel D
ND
Devadason
Sunalene G
SG
Hall
Graham L
GL
Hamacher
Jürg
J
Arheden
Lars
L
LeSouëf
Peter N
PN
D001993:Bronchodilator Agents; D002675:Child, Preschool; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000502:physiology*; D005652:Functional Residual Capacity / Q000502:physiology*; D006801:Humans; D007223:Infant; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D008297:Male; D009035:Mothers; D015588:Observer Variation; D010820:Physicians; D012135:Respiratory Sounds / Q000209:etiology / Q000502:physiology*; D012720:Severity of Illness Index; D013726:Terbutaline
D001993:Bronchodilator Agents; D013726:Terbutaline