title: Evaluation of isotonic sodium bicarbonate solution for alkalizing effects in conscious calves.
abstract: After intravenous (i.v.) infusion of various volumes of 1.35%-isotonic sodium bicarbonate solution (ISB), acid-base equilibrium, blood pressure, plasma volume and biochemical parameters in healthy Holstein calves were studied. Four calves each were randomly assigned to the low-dose (LD; i.v. infusion of 5 ml/kg ISB), middle-dose (MD; i.v. infusion of 10 ml/kg ISB) and the high-dose groups (HD; i.v. infusion of 15 ml/kg ISB). Administration volumes of ISB in the LD, MD and HD groups were decided based on the first half volumes of 5, 10 and 15 mEq of base requirement by the acceptable equation. Systemic, pulmonary artery and central venous pressures, cardiac output and plasma osmotic pressure were not changed by ISB infusion and remained constant throughout the experiment for all groups. There was good correlation (r(2) = 0.950) between relative changes in base excess and infused volume of bicarbonate (y=2.491x). The coefficient of distribution for bicarbonate ions was calculated to be 0.401 (=1/2.491). Therefore, it is suggested that a value of 0.4 would be most appropriate when calculating the base requirements in calves. Therefore, the first half volumes of ISB correcting base deficits of 5, 10 and 15 mEq in calves were estimated to be 6, 12 and 18 ml/kg, respectively. On the basis of the findings in this study, ISB may be used to correct metabolic acidosis without altering the plasma osmotic pressure, hemodynamic status and respiratory function in the calves.
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Izumi
authors.initials: I
authors.lastname: Abe
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Iwabuchi
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Tsumagari
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Ryuji
authors.initials: R
authors.lastname: Asano
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000628:therapy / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle; D002418:Cattle Diseases / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D005440:Fluid Therapy / Q000379:methods / Q000662:veterinary*; D007262:Infusions, Intravenous / Q000662:veterinary; D007552:Isotonic Solutions; D008297:Male; D010953:Plasma Volume / Q000187:drug effects / Q000662:veterinary; D011897:Random Allocation; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D007552:Isotonic Solutions; D017693:Sodium Bicarbonate