Long-term follow-up of globus pallidus chronic stimulation in advanced Parkinson's disease.
To assess the long-term follow-up of the globus pallidus internus (GPi) stimulation, six patients were evaluated every year by using the Unified Parkinson's Disease Rating Scale (UPDRS). Three years postoperatively, GPi stimulation led to a significant improvement of dyskinesia severity (50%, P = 0.05) and activities of daily living (subscore of quality of life scale, 9%, P = 0.05). However, the improvement induced by chronic pallidal stimulation on the mean daily duration in the off state was lost at the last assessment.
Durif
Franck
F
Fédération de Neurologie, Hôpital Gabriel Montpied, Clermont Ferrand, France. fdurif@chu-clermontferrand.fr
Lemaire
Jean-Jacques
JJ
Debilly
Bérengère
B
Dordain
Gérard
G
D000203:Activities of Daily Living / Q000145:classification; D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004292:Dominance, Cerebral / Q000502:physiology; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011788:Quality of Life
D000978:Antiparkinson Agents; D007980:Levodopa