Large-scale Homologous Analysis of Genome Sequence.
We described a new method for the large-scale homologous analysis of genome sequences, which used hashing technique combined with sparse dynamic programming to get a sequence alignment. Three examples, the plant chloroplast genomes, the mammalian T-cell receptors C(alpha)/C(delta) gene loci and the mammalian gamma-crystallin gene clusters were analysed. The results showed that the method was more rapid to obtain accurate enough data and might be useful in genome analysis.
Tang
Hai-Xu
HX
Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China.
Ding
Da-Fu
DF