A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers.
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.
Goedde
Rene
R
Department of Molecular Human Genetics, Ruhr-University, Universitätsstrasse 150, 44780 Bochum, Germany. rene.goedde@ruhr-uni-bochum.de
Sawcer
Stephen
S
Boehringer
Stefan
S
Miterski
Bianca
B
Sindern
Eckhart
E
Haupts
Michael
M
Schimrigk
Sebastian
S
Compston
Alastair
A
Epplen
Joerg T
JT
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005820:Genetic Testing; D015894:Genome, Human; D005858:Germany; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology*
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains