Screening of South American plants against human immunodeficiency virus: preliminary fractionation of aqueous extract from Baccharis trinervis.
Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.
Sanchez Palomino
Sonsoles
S
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Abad
Maria José
MJ
Bedoya
Luis Miguel
LM
García
Javier
J
Gonzales
Eduardo
E
Chiriboga
Ximena
X
Bermejo
Paulina
P
Alcami
José
J
D031175:Baccharis; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D013020:South America
D010936:Plant Extracts