Synthesis and structure of a stabilized 10-membered cyclic enediyne.
The synthesis and structure of an acetal protected 10-membered cyclic enediyne-1,2-diol rac-10 is reported. The conformational constrain of the unsaturated macrocycle by the acetal protection group prevents the thermal cyclization reaction of the endiyne during synthesis and purification.
Pitsch
Wolfgang
W
Institut für Organische Chemie, Universität Regensburg, D-93040 Regensburg, Germany.
Klein
Michael
M
Zabel
Manfred
M
König
Burkhard
B