Analogues of aspartic proteases synthesized by densely covering silica gel with carboxyl groups.
Aspartic protease analogues synthesized by covering the surface of silica gel with carboxyl groups effectively hydrolyzed hemoglobin and gamma-globulin. It is proposed that the carboxyl group is involved in both complexation of the protein substrate and the catalytic cleavage of the peptide bonds of the complexed proteins.
Kim
Hyunsook
H
School of Chemistry and Center for Molecular Catalysis, Seoul National University, Republic of Korea.
Chung
Yeon-Sook
YS
Paik
Hyesun
H
Kim
Myoung-soon
MS
Suh
Junghun
J
D000327:Adsorption; D000418:Albumins / Q000737:chemistry; D016282:Aspartic Acid Endopeptidases / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006454:Hemoglobins / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D010047:Ovalbumin / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D005719:gamma-Globulins / Q000737:chemistry
D000418:Albumins; D006454:Hemoglobins; D010455:Peptides; D005719:gamma-Globulins; D058428:Silica Gel; D012822:Silicon Dioxide; D010047:Ovalbumin; D016282:Aspartic Acid Endopeptidases