Mode of action of gabapentin in chronic neuropathic pain syndromes. A short review about its cellular mechanisms in nociceptive neurotransmission.
Gabapentin (GBP, CAS 60142-96-3) has anticonvulsant and antinociceptive properties; the latter relate especially to chronic neuropathic pain. The mode of action of GBP, possibly different in epilepsy and chronic pain syndromes, is only poorly understood. This minireview is aimed at compiling the different mechanisms by which GBP may diminish the nociceptive transmission in the dorsal horn of the spinal cord.
Surges
Rainer
R
Sektion Klinische Neuropharmakologie, Neurologische Universitätsklinik Freiburg/Breisgau, Germany.
Feuerstein
Thomas J
TJ
D000085:Acetates / Q000494:pharmacology / Q000627:therapeutic use*; D000588:Amines; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D015220:Calcium Channels / Q000187:drug effects; D002908:Chronic Disease; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000077206:Gabapentin; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000085:Acetates; D000588:Amines; D015306:Biogenic Monoamines; D015220:Calcium Channels; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin