N-substituted hydroxyureas as urease inhibitors.
In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl- (10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.
Uesato
Shinichi
S
Department of Biotechnology, Faculty of Engineering, Kansai Univeristy, Suita, Osaka, Japan. uesato@ipcku.kansai-u.ac.jp
Hashimoto
Yuichiro
Y
Nishino
Masaru
M
Nagaoka
Yasuo
Y
Kuwajima
Hiroshi
H
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000737:chemistry*; D007887:Fabaceae / Q000201:enzymology; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D014510:Urease / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D014510:Urease; D006918:Hydroxyurea