Transcript elongation on a nucleoprotein template.
Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and histone modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and biochemical studies of transcription have identified a set of accessory factors for transcript elongation by RNA polymerase II (Pol II) that appear to function in the context of chromatin. The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin.
Hartzog
Grant A
GA
Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. hartzog@biology.ucsc.edu
Speer
Jennifer L
JL
Lindstrom
Derek L
DL
D002843:Chromatin / Q000235:genetics; D005786:Gene Expression Regulation; D009698:Nucleoproteins / Q000235:genetics*; D009707:Nucleosomes / Q000737:chemistry / Q000378:metabolism; D010441:Peptide Chain Elongation, Translational; D010442:Peptide Chain Initiation, Translational; D012319:RNA Polymerase II / Q000737:chemistry / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D013698:Templates, Genetic; D035165:Transcription Factors, General / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*; D035602:Transcriptional Elongation Factors / Q000737:chemistry / Q000378:metabolism
D002843:Chromatin; D009698:Nucleoproteins; D009707:Nucleosomes; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors; D012319:RNA Polymerase II