A new one-pot three-component condensation reaction for the synthesis of 5-deaza-5,8-dihydropterins.
The one-pot cyclocondensation of 2,6-diaminopyrimidin-4-one, an aromatic or aliphatic aldehyde and a beta-ketoester in acetic acid, or dimethyl sulfoxide in the presence of zinc(II) bromide, under thermal conditions provided dihydropyrido[2,3-d]pyrimidin-4(3H)-ones in good yield and with total regiocontrol.
Bagley
M C
MC
Department of Chemistry, Cardiff University, PO Box 912, Cardiff, UK CF10 3TB. bagleymc@cf.ac.uk
Singh
N
N