Development of the sensory organs.
The sensory organs--the eye, ear, and nose- are formed, in part, from ectodermal thickenings: placodes. Their development is distinct from that of other regions of the developing body and they are essential for the development of other structures. For example, the olfactory placode which gives rise to the nose is essential for the functional development of the reproductive organs and hence fertility. Recently much progress has been made in the understanding of placode development, at both a molecular and embryological level. This is important as abnormal development of placodes occurs in a number of human syndromes. Furthermore, knowledge of placode development will give insight into therapeutic strategies to prevent degenerative change such as deafness. This review highlights the current knowledge of placode development and the future challenges in unravelling the cascades of signalling interactions that control development of these unique structures.
Francis-West
Philippa H
PH
Department of Craniofacial Development, King's College London, London Bridge, SE1 9RT.
Ladher
Raj K
RK
Schoenwolf
Gary C
GC
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004475:Ectoderm / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis / Q000235:genetics; D012679:Sense Organs / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development