[Effect of new chemotherapeutic methods on the biologic tissue environment and on the immune status of patients with breast cancer].
Standard (SCT), autoplasmochemotherapy using cytostatics preincubation with autoplasma (APCT) and autoblood (autohemochemotherapy--AHCT) were compared to evaluate their effects on locally advanced breast tumors. SCT showed marked immunosuppressor effect while APCT and, particularly, AHCT--a sparing one. The use of the latter modalities involved significantly higher levels of active T-, NK- and cytotoxic CD+ 8 cells. A comparison of the latter methods also showed ABCT to yield a better subset balance between T- and B-cells and a higher level of their mitogen response.
Sidorenko
Iu S
IuS
Research Institute of Oncology, the Ministry of Health of the RF, Rostov-on-Don.
Zlatnik
E Iu
EIu
Vladimirova
L Iu
LIu
Zakora
G I
GI
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000276:immunology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008875:Middle Aged; D010949:Plasma / Q000276:immunology*
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor