title: No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer Disease.
abstract: Nitric oxide synthase (NOS) has been implicated in the pathogenesis of Alzheimer disease (AD). To examine the role of the neuronal NOS (nNOS) gene in AD, patients (n = 139) and control subjects (n = 101) were genotyped for the nNOS dinucleotide polymorphism. No association was demonstrated for AD and this particular nNOS polymorphism.
authors.affiliation: Section of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, Republic of China.
authors.forename: Ying-Jay
authors.initials: YJ
authors.lastname: Liou
authors.forename: Chen-Jee
authors.initials: CJ
authors.lastname: Hong
authors.forename: Hsiu-Chih
authors.initials: HC
authors.lastname: Liu
authors.forename: Chia-Yih
authors.initials: CY
authors.lastname: Liu
authors.forename: Tsung-Yun
authors.initials: TY
authors.lastname: Liu
authors.forename: I-Chun
authors.initials: IC
authors.lastname: Chen
authors.forename: Shih-Jen
authors.initials: SJ
authors.lastname: Tsai
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D018900:Dinucleotide Repeats; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009474:Neurons / Q000201:enzymology / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052248:Nitric Oxide Synthase Type I; D011110:Polymorphism, Genetic
chemical_list: C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I