2,5-Pyridinedicarboxylic acid derivatives as non-nucleosidic reverse transcriptase inhibitors of hepatitis B virus.
2,5-Pyridinedicarboxylic acid derivatives were found to be the potent non-nucleoside inhibitors of hepatitis B virus (HBV) with IC(50) <or=0.01 microg/mL in a reverse transcriptase inhibitory effect. And they showed the low toxicity compared with the nucleoside analogues.
Lee
JinSoo
J
Central Research Laboratory, DongWha Pharm. Ind. Co. Ltd., Seoul, South Korea.
Shim
HyungSoo
H
Park
YongKyun
Y
Park
SangJin
S
Shin
JoonSu
J
Yang
WangYong
W
Lee
HakDong
H
Park
WhuiJung
W
Chung
YongHo
Y
Lee
SangWook
S
D002460:Cell Line; D006515:Hepatitis B virus / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007202:Indicators and Reagents; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*
D007202:Indicators and Reagents; D011725:Pyridines; D018894:Reverse Transcriptase Inhibitors; C043093:2,5-Pyridinedicarboxylic acid