title: Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue.
abstract: A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5-20 fold) and in a reduced dinucleotide coenzyme (2-3 fold), while retaining reactivity towards hydride transfer.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
authors.forename: P L
authors.initials: PL
authors.lastname: Hentall
authors.forename: N
authors.initials: N
authors.lastname: Flowers
authors.forename: T D
authors.initials: TD
authors.lastname: Bugg
mesh_terms: D000143:Acids / Q000737:chemistry; D003067:Coenzymes / Q000737:chemistry; D004355:Drug Stability; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D015394:Molecular Structure; D009243:NAD / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D000143:Acids; D003067:Coenzymes; D009243:NAD