[Phenomenology of patients with early and adult onset obsessive-compulsive disorder].
OBJECTIVE
To evaluate potential differences in socio-demographic and clinical characteristics (obsessive-compulsive symptomatology, axis I and II comorbidity) between OCD adults with an early age at onset (< 18 years) and later onset, (> or = 18 yrs).


METHODS
Clinical controlled study.


METHODS
Anxiety and Mood Disorders Unit, Department of Neuroscience, University of Turin.


METHODS
We included 149 subjects with a principal diagnosis of OCD (DSM-IV) and a Y-BOCS total score > or = 16. All patients underwent a semistructured clinical interview aimed at investigating sociodemographic characteristics and clinical features of the disorder. Lifetime Axis I comorbidity, according to DSM-IV criteria, was investigated with a structured interview following Othmer & Othmer guidelines (1994; 1999). Personality disorders were assessed using the Structured Clinical Interview for DSM-IV Axis II Disorders (SCID-II).


RESULTS
39 patients referred age at onset of OCD before 18 years (early-onset group) and 110 patients at 18 years or later (later-onset group). Significant differences were found between the two groups: early-onset subjects are characterized by a preponderance of males, a chronic course of illness and a strong association with Schizotypal Personality Disorder.


CONCLUSIONS
When subtyping OCD according to age at onset we found significant differences which suggest a possible heterogeneity of the disorder. Our results seem to confirm that early-onset OCD may represent a more severe subgroup, with clinical characteristics such as the chronic course and the high association with Schizotypal PD which are significant in order to apply specific therapeutic strategies.
Albert
Umberto
U
Servizio per i disturbi depressivi e d'ansia, Dipartimento di Neuroscienze, Università degli Studi di Torino, Torino.
Picco
Chiara
C
Maina
Giuseppe
G
Forner
Federica
F
Aguglia
Eugenio
E
Bogetto
Filippo
F
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D012720:Severity of Illness Index; D017678:Sex Distribution; D012959:Socioeconomic Factors