Esthesioneuroblastoma in children.
Esthesioneuroblastoma (olfactory neuroblastoma) is a rare tumor of the olfactory epithelium. Approximately 1,000 cases have been described in the literature since the original description in 1924. It occurs in older individuals and is rare in children. The authors describe the clinicopathologic presentation in a series of five children treated with neoadjuvant/adjuvant chemotherapy and review the English literature for previously described patients younger than 18 years to assess clinical presentation, mode of treatment, and outcome in this age group.
Kumar
Manjusha
M
Departments of Pediatrics and Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5225, USA. mkumar@iupui.edu
Fallon
Robert J
RJ
Hill
James S
JS
Davis
Mary M
MM
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D018304:Esthesioneuroblastoma, Olfactory / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D010255:Paranasal Sinus Neoplasms / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D011878:Radiotherapy; D016896:Treatment Outcome