title: Transmural gradients of cardiac myofiber shortening in aortic valve stenosis patients using MRI tagging.
abstract: Aortic valve stenosis impairs subendocardial perfusion with a risk of irreversible subendocardial tissue damage. A likely precursor of damage is subendocardial contractile dysfunction, expressed by the parameter TransDif, which is defined as epicardial minus endocardial myofiber shortening, normalized to the mean value. With the use of magnetic resonance tagging in two short-axis slices of the left ventricle (LV), TransDif was derived from LV torsion and contraction during ejection. TransDif was determined in healthy volunteers (control, n = 9) and in patients with aortic valve stenosis before (AVSten, n = 9) and 3 mo after valve replacement (AVRepl, n = 7). In the control group, TransDif was 0.00 +/- 0.14 (mean +/- SD). In the AVSten group, TransDif increased to 0.96 +/- 0.62, suggesting impairment of subendocardial myofiber shortening. In the AVRepl group, TransDif decreased to 0.37 +/- 0.20 but was still elevated. In eight of nine AVSten patients, the TransDif value was elevated individually (P < 0.001), suggesting that the noninvasively determined parameter TransDif may provide important information in planning of treatment of aortic valve stenosis.
authors.affiliation: Department of Biophysics, Maastricht University, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Van Der Toorn
authors.forename: P
authors.initials: P
authors.lastname: Barenbrug
authors.forename: G
authors.initials: G
authors.lastname: Snoep
authors.forename: F H
authors.initials: FH
authors.lastname: Van Der Veen
authors.forename: T
authors.initials: T
authors.lastname: Delhaas
authors.forename: F W
authors.initials: FW
authors.lastname: Prinzen
authors.forename: J
authors.initials: J
authors.lastname: Maessen
authors.forename: T
authors.initials: T
authors.lastname: Arts
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D018485:Muscle Fibers, Skeletal / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D014102:Torsion Abnormality; D016277:Ventricular Function, Left