title: High intake, but not low intake, of CLA impairs weight gain in growing mice.
abstract: CLA has a range of biological properties, including effects on lipid metabolism and body composition in experimental animals. The prevalent isomer of CLA found in the human diet is 9c,11 t-CLA, and it is predominantly found in products containing fat from ruminant animals. This study investigated the effect of dietary CLA on energy balance in mice. Synthetic CLA reduced body fat in growing male BALB/c mice in a dose-dependent manner over the range 0.25-1.0% w/w CLA in the diet. Weight gain was also reduced at the highest levels of dietary CLA, being only 5.88 +/- 2.68 g/4 mice (mean +/- 1 SD) after 4 wk of 2.0% CLA in the diet, compared with weight gains of 7.51 +/- 2.22 to 8.17 +/- 2.34 g/4 mice in the 0-0.5% CLA groups. There was no significant effect on weight gain if diets contained 0.5% synthetic CLA or less. These results suggest that high levels of a synthetic mixture of CLA isomers modify energy metabolism and body composition and that high levels of synthetic CLA impair weight gain and reduce body fat pad mass in growing mice.
authors.affiliation: Milk and Health Research Centre, Massey University, Palmerston North, New Zealand.
authors.forename: Ann
authors.initials: A
authors.lastname: Hayman
authors.forename: Alastair
authors.initials: A
authors.lastname: MacGibbon
authors.forename: Rodger J
authors.initials: RJ
authors.lastname: Pack
authors.forename: Kay
authors.initials: K
authors.lastname: Rutherfurd
authors.forename: J Hilary
authors.initials: JH
authors.lastname: Green
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D019787:Linoleic Acid / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D004041:Dietary Fats; D019787:Linoleic Acid