TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat carotid body.
In the present study, we investigated the immunohistochemical localization of two-pore K(+)-channels TASK-1, TASK-2, TASK-3 and TRAAK in the rat carotid body. Type I cells were positive for TASK-1, TASK-2, TASK-3 and TRAAK. Intrinsic nerve cell bodies were also strongly positive for TASK-1, TASK-2 and TRAAK, but negative for TASK-3. In addition, some type II cells, Schwann cells in the nerve bundles and fibroblast between type I cell clusters were also immunostained for TASK-1. Smooth muscle cells of the carotid body artery were intensely positive for TASK-3. Our results indicate that TASK-1 immunoreactivity was ubiquitously distributed in many cell types and immunoreactivities for TASK-2, TASK-3 and TRAAK were cell type specific distribution patterns in the rat carotid body.
Yamamoto
Yoshio
Y
Laboratory of Veterinary Anatomy, Faculty of Agriculture, Gifu University, 501-1193, Gifu, Japan. yyoshio@iwate-u.ac.jp
Kummer
Wolfgang
W
Atoji
Yasuro
Y
Suzuki
Yoshitaka
Y
D000818:Animals; D002344:Carotid Body / Q000737:chemistry* / Q000166:cytology; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis*; D015221:Potassium Channels / Q000032:analysis*; D024683:Potassium Channels, Tandem Pore Domain; D051381:Rats; D017208:Rats, Wistar
C503432:KCNK4 protein, human; C503434:Kcnk4 protein, rat; C498740:Kcnk5 protein, rat; C407082:Kcnk9 protein, rat; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain; C420132:potassium channel subfamily K member 3