title: Metastatic cutaneous melanoma to the vitreous cavity masquerading as intermediate uveitis.
abstract: OBJECTIVE
  To report a patient with metastatic cutaneous melanoma (MCM) presenting as intermediate uveitis.
  
  
  METHODS
  We examined a 49-year-old man with malignant cutaneous melanoma and central nervous system (CNS) metastasis who was initially treated for bilateral intermediate uveitis. Biomicroscopic examination disclosed a normal anterior segment and vitreous organization with red blood cells (RBC) and some non-pigmented cells in both eyes. Funduscopy disclosed a retinal metastasis in the right eye, but vitreous organization precluded visualization of the retina in the left eye.
  
  
  RESULTS
  The first diagnostic vitrectomy was negative for malignant cells in the left eye. However, progressive worsening of the condition persuaded us to repeat vitrectomy in the left eye and to do it in the right eye too. Vitreous samples were positive for malignant melanoma cells in both eyes.
  
  
  CONCLUSIONS
  Metastatic cutaneous melanoma to the vitreous cavity is exceedingly rare and may masquerade as intermediate uveitis. It should be considered in the differential diagnosis of unusual uveitis and masquerade syndromes.
authors.affiliation: Ophthalmology Department and Eye Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Labbafi@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Soheilian
authors.forename: F
authors.initials: F
authors.lastname: Mirbabai
authors.forename: M
authors.initials: M
authors.lastname: Shahsavari
authors.forename: M
authors.initials: M
authors.lastname: Parvin
authors.forename: F
authors.initials: F
authors.lastname: Manieei
mesh_terms: D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008545:Melanoma / Q000556:secondary*; D008875:Middle Aged; D019572:Retinal Neoplasms / Q000556:secondary*; D012878:Skin Neoplasms / Q000473:pathology*; D015867:Uveitis, Intermediate / Q000175:diagnosis*; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology*