title: Cell surface immunoglobulin receptors in B cell development.
abstract: Expression of surface immunoglobulin (sIg) related receptors has been conserved in phylogenetically distinct species as a critical checkpoint in B cell development. The sIg receptor comprises extracellular IgM heavy and light chains, with the potential for ligand binding, complexed to the Igalpha/Igbeta heterodimer that is responsible for signal transduction through sIg. Experimental systems, from both avian and murine models of B cell development, have been designed to identify the function of individual receptor components in B cell development. In this review, we assess the regulatory functions of different components of the sIg receptor complex during early development in experimental systems from evolutionarily distinct species.
authors.affiliation: Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ont., Canada M5S 1A8.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Pike
authors.forename: Michael J H
authors.initials: MJ
authors.lastname: Ratcliffe
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D019281:Dimerization; D018507:Gene Expression Regulation, Developmental / Q000276:immunology; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000235:genetics / Q000276:immunology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology*; D054420:Pre-B Cell Receptors; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013045:Species Specificity
chemical_list: D007075:Immunoglobulin M; D008562:Membrane Glycoproteins; D054420:Pre-B Cell Receptors; D011947:Receptors, Antigen, B-Cell