[The study of changes of basement membrane in gingivae of adult periodontitis].
The major components of basement membrane including laminin and type IV collagen were studied by immunohistochemistry in 20 gingival specimens from patients with moderate to severe adult periodontitis and 10 normal gingival specimens combing with electron microscopic and PAS analysis. The results showed that laminin and type IV collagen were both present and stained with a continuous liner pattern in oral sulcular epithelium of the normal gingivae, while the pocket epithelial alterations of the periodontitis occurred, which included thinning, interruption, partial or complete absence of basement membrane involving one or more rete pegs and fragmentations. All these alterations may play an important role in the pathogenesis of adult periodontitis.
Zheng
R
R
College of Stomatology, Hubei Medical University.
Wang
S
S
Shu
Q
Q
D000328:Adult; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D024141:Collagen Type IV / Q000378:metabolism; D005260:Female; D005881:Gingiva / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007797:Laminin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000473:pathology*
D024141:Collagen Type IV; D007797:Laminin