[Effects of acute hypobaric hypoxia on the distribution of somatostatin contents in lower gastrointestinal tract of rats].
OBJECTIVE
To examine the effects of acute hypobaric by hypoxia on the distribution of Somatostatin (SS) contains in lower gastrointestinal tract of rats.


METHODS
36 Wistar [correction of Wister] male rats were divided into 6 groups. Three were control groups, three were ulcerous groups. Each group contains ground, 5000 m above sea level and 10000 m above sea level. SS contents were determined with radioimmunoassay [correction of radioimmunoassy] methods.


RESULTS
Statistically significant difference was exhibited among each group. There was no significant difference of SS contents in each altitude between model and control. SS contents were significantly increased in intestine of control in 5000 m groups, in caecum in 5000 m groups, compared with that in ground (P<0.05). It was also significantly increased in intestine of model in 5000 m groups, in caecum in 5000 m groups, compared with that in ground (P<0.01). SS contents was significantly increased in caecum of model in 10000 m groups compared with that in ground (P<0.05). Except this, There was no significant difference of ss contents in lower gastrointestinal tract among each group.


CONCLUSIONS
SS contents in lower gastrointestinal tract were significantly increased in acute hypobaric hypoxia rats. This result suggested that ss contents in lower gastrointestinal tract may play an important protective role in acute hypobaric hypoxia rats.
Wu
Z J
ZJ
Department of gastroenterology, 456th hospital of PLA, Jinaa, China.
Zhong
X J
XJ
Sun
Y P
YP
Xu
G
G
Xu
K G
KG
Tian
G Q
GQ
D000531:Altitude; D000818:Animals; D001274:Atmospheric Pressure; D002432:Cecum / Q000378:metabolism* / Q000502:physiology; D004064:Digestive System / Q000378:metabolism / Q000503:physiopathology; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin