Successful salvage therapy of irinotecan for relapsed Hodgkin's lymphoma.
A 30-year-old man, who had a repeated history of relapsed Hodgkin's lymphoma over 7 years, developed bilateral pleural effusion and chest wall involvement. He was treated with weekly irinotecan hydrochloride (CPT-11; 80 mg/m2/week). Partial response was observed after two cycles of irinotecan. Neutropenia and diarrhea were tolerable. This case demonstrated that irinotecan has a therapeutic effect in patients with relapsed Hodgkin's lymphoma.
Urushihata
Kazuhisa
K
First Department of Medicine, Shinshu University, Matsumoto.
Koizumi
Tomonobu
T
Kaneki
Toshimichi
T
Yamaguchi
Shinji
S
Fujimoto
Keisaku
K
Kubo
Keishi
K
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D000077146:Irinotecan; D008297:Male; D011859:Radiography; D012008:Recurrence; D016879:Salvage Therapy; D059004:Topoisomerase I Inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; D000077146:Irinotecan; D002166:Camptothecin