Contribution of the interleukin-1beta gene polymorphism in multiple system atrophy.
We studied genetic polymorphisms in the promoter region at position -511 of the interleukin (IL) -1beta gene (IL-1B-511) and at position -889 of the IL-1alpha gene (IL-1A-889), in 111 Japanese patients with multiple system atrophy (MSA) and 160 controls. The distribution of IL-1B-511 was significantly different between MSA patients and controls, because of the under-representation of patients with homozygotes for allele 2 (IL-1B-511*2), a high producer of IL-1beta. The frequency of IL-1A-889*2, a high secretor of IL-1alpha, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA.
Nishimura
Masataka
M
Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan. m_nishim@clin.med.tokushima-u.ac.jp
Kawakami
Hideshi
H
Komure
Osamu
O
Maruyama
Hirofumi
H
Morino
Hiroyuki
H
Izumi
Yuishin
Y
Nakamura
Shigenobu
S
Kaji
Ryuji
R
Kuno
Sadako
S
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012016:Reference Values
D007375:Interleukin-1