Three-dimensional myocardial strains at end-systole and during diastole in the left ventricle of normal humans.
This paper presents the three-dimensional strains in the normal human left ventricle (LV) at end-systole and during diastole. Magnetic resonance tissue tagging was used to measure strain in the left-ventricular heart wall in 10 healthy volunteers aged between 28 and 61 years. The three-dimensional motion was calculated from the displacement of marker points in short- and long-axis cine images, with a time resolution of 30 msec. Homogeneous strain analysis of small tetrahedrons was used to calculate deformation in 18 regions of the LV over a time span of 300 msec starting at end systole. End-systolic radial strain was largest near the heart base, and circumferential and longitudinal strains were largest near the apex. During diastole, the circumferential-longitudinal shear strain (associated with LV torsion) was found to recover earlier than the axial strains. Assessment of three-dimensional diastolic strain is possible with MR tagging. Comparison of patient strain against normal strain may permit early detection of regional diastolic dysfunction.
Kuijer
Joost P A
JP
Department of Clinical Physics and Informatics, Institute for Cardiovascular Research ICaR-VU, Vrije Universiteit, Amsterdam, The Netherlands. jpa.kuijer@vumc.nl
Marcus
J Tim
JT
Götte
Marco J W
MJ
van Rossum
Albert C
AC
Heethaar
Robert M
RM
D000328:Adult; D003971:Diastole / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D015588:Observer Variation; D012016:Reference Values; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*