Effects of D2-dopamine and alpha-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice.
The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms.
Fiserová
Anna
A
Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Prague 4, Czech Republic. fiserova@biomed.cas.cz
Starec
Miroslav
M
Kuldová
Markéta
M
Kovárů
Hana
H
Páv
Marek
M
Vannucci
Luca
L
Pospísil
Miloslav
M
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D001921:Brain / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D002395:Catecholamines / Q000276:immunology; D018492:Dopamine Antagonists / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D019204:GTP-Binding Proteins / Q000276:immunology; D007107:Immune System / Q000187:drug effects / Q000276:immunology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000276:immunology; D009490:Neurosecretory Systems / Q000187:drug effects / Q000276:immunology*; D010641:Phenotype; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000276:immunology*; D017448:Receptors, Dopamine D2 / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013312:Stress, Physiological / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D000317:Adrenergic alpha-Antagonists; D002395:Catecholamines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D011942:Receptors, Adrenergic, alpha; D017448:Receptors, Dopamine D2; D019204:GTP-Binding Proteins