title: Preferential involvement of larger vessels in a rat model of diabetes-induced graft vasculopathy.
abstract: Using previously described models of diabetes-induced transplant coronary artery atherosclerosis (TxCAD), we quantitatively assessed TxCAD using computer-assisted morphometric measurements. More than 95% of the evaluated vessels were intramyocardial vessels. The first and last tertile of the vessel size distribution were evaluated for the presence of TxCAD. Severe TxCAD, defined as a luminal occlusion > or =75%, was more prevalent in the larger vessels. We observed a differential involvement based on vessel size in diabetes-induced TxCAD.
authors.affiliation: Division of Cardiovascular Medicine, Stanford University School of Medicine, California, USA.
authors.forename: Bernard
authors.initials: B
authors.lastname: Cantin
authors.forename: Dening
authors.initials: D
authors.lastname: Zhu
authors.forename: Peizhong
authors.initials: P
authors.lastname: Wen
authors.forename: Shyam N
authors.initials: SN
authors.lastname: Panchal
authors.forename: Judith K
authors.initials: JK
authors.lastname: Gwathmey
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Reaven
authors.forename: Hannah A
authors.initials: HA
authors.lastname: Valantine
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000473:pathology*; D006083:Graft Occlusion, Vascular / Q000473:pathology*; D016027:Heart Transplantation / Q000009:adverse effects; D023421:Models, Animal; D051381:Rats; D013311:Streptozocin
chemical_list: D013311:Streptozocin