Pharmacokinetics and acute lipolytic actions of growth hormone. Impact of age, body composition, binding proteins, and other hormones.
The biologic actions of endogeneous growth hormone (GH) depend on its secretion and clearance rates as well as sensitivity at the receptor level. Aberrations in GH pharmacokinetics and pharmacodynamics may occur with increasing age, and have been implicated in diseases such as obesity, diabetes mellitus, and critical illness. In this review, recent insights into the association between GH metabolism and age, body composition, binding proteins and other hormones are discussed.
Hansen
Troels Krarup
TK
Medical Department M (Endocrinology and Diabetes) Aarhus University Hospital, DK-8000 Aarhus C, Denmark. tkh@dadlnet.dk
D000328:Adult; D000367:Age Factors; D001823:Body Composition; D002352:Carrier Proteins / Q000378:metabolism; D004351:Drug Resistance; D006728:Hormones / Q000378:metabolism; D019382:Human Growth Hormone / Q000493:pharmacokinetics* / Q000494:pharmacology*; D006801:Humans; D008066:Lipolysis / Q000187:drug effects*; D008875:Middle Aged; D008954:Models, Biological; D011986:Receptors, Somatotropin / Q000378:metabolism; D011994:Recombinant Proteins / Q000493:pharmacokinetics / Q000494:pharmacology
D002352:Carrier Proteins; D006728:Hormones; D011986:Receptors, Somatotropin; D011994:Recombinant Proteins; D019382:Human Growth Hormone; C051815:somatotropin-binding protein