A monoclonal antibody to the amebic lipophosphoglycan-proteophosphoglycan antigens can prevent disease in human intestinal xenografts infected with Entamoeba histolytica.
Entamoeba histolytica trophozoites are covered by lipophosphoglycan-peptidoglycan molecules which may be key virulence factors. We found that pretreatment of severe combined immunodeficient mice bearing human intestinal xenografts with a monoclonal antibody to the amebic lipophosphoglycan-peptidoglycan molecules can prevent or significantly reduce the human intestinal inflammation and tissue damage that are normally seen with E. histolytica colonic infection.
Zhang
Zhi
Z
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Duchêne
Michael
M
Stanley
Samuel L
SL
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000913:Antibodies, Protozoan / Q000494:pharmacology*; D000953:Antigens, Protozoan; D003106:Colon / Q000276:immunology / Q000473:pathology / Q000637:transplantation; D004404:Dysentery, Amebic / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D004748:Entamoeba histolytica / Q000276:immunology* / Q000472:pathogenicity*; D006028:Glycosphingolipids / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D051379:Mice; D016513:Mice, SCID; D011509:Proteoglycans / Q000276:immunology; D015800:Protozoan Proteins / Q000276:immunology; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D006028:Glycosphingolipids; D011509:Proteoglycans; D015800:Protozoan Proteins; C008290:lipophosphonoglycan