One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction.
A modification of the Sonogoshira coupling reaction employing an amidine base and a substoichiometric amount of water generates symmetrical and unsymmetrical bisarylethynylenes in one pot through in situ deprotection of trimethylsilylethynylene-added intermediates.
Mio
Matthew J
MJ
Department of Chemistry, Macalester College, St. Paul, Minnesota 55105, USA.
Kopel
Lucas C
LC
Braun
Julia B
JB
Gadzikwa
Tendai L
TL
Hull
Kami L
KL
Brisbois
Ronald G
RG
Markworth
Christopher J
CJ
Grieco
Paul A
PA
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D012997:Solvents; D013696:Temperature
D006574:Heterocyclic Compounds, 2-Ring; D012997:Solvents; D010165:Palladium; D003300:Copper