Cell division: MAST sails through mitosis.
Successful mitosis requires coordinated activities of microtubules and numerous associated proteins. A recent study implicates the microtubule-associated protein MAST/Orbit in a surprisingly wide array of mitotic activities, ranging from maintaining mitotic spindle bipolarity to tethering chromosomes to the ends of microtubules.
Sharp
David J
DJ
Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. dsharp@aecom.yu.edu
D000818:Animals; D020090:Chromosome Segregation / Q000502:physiology*; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008938:Mitosis; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D013045:Species Specificity; D008941:Spindle Apparatus / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure
D029721:Drosophila Proteins; C084034:Klp61F protein, Drosophila; D008869:Microtubule-Associated Proteins; C091278:STU1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C407307:chb protein, Drosophila