[Acute liver failure in nefazodone therapy? A case report].
Antidepressant-induced hepatotoxicity is generally considered of minimal clinical importance and is not well recognized. We report on a patient with recurrent major depression who was treated with nefazodone. Six weeks after initiation of therapy with nefazodone, he developed fatal liver failure. After cessation of the drug, the patient did not recover. He underwent liver transplantation but unfortunately died.
Ehrentraut
S
S
Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 München. Ehrentraut.Sigrid@psy.med.uni-muenchen.de
Rothenhäusler
H B
HB
Gerbes
A L
AL
Rau
H G
HG
Thiel
M
M
Schirren
C A
CA
Kapfhammer
H P
HP
D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D017809:Fatal Outcome; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010879:Piperazines; D012008:Recurrence; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use
D000928:Antidepressive Agents; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone