title: [Gene expression of Interleukin 1 in vitamin A and proteins deficiency].
abstract: The influence of low levels of protein and vitamin A on indicators of the immune response was assayed in rats. The levels of protein and vitamin A intake of the Cuban population affected by epidemic neuropathy in 1993 was reproduced in 4 diets: control, protein deficiency (DP), vitamin A deficiency (DA), protein and vitamin A deficiency (DAP). The Peyer's patches evaluated the Interleukin 1 expression gene and was related with corporal weight, food intake, serum protein, vitamin A, immunology indicators and histology evaluation (spleen, thymus and liver). Protein deficiency generated a significant decrease of the expression gene of Interleukin 1. Atrophy signs in lymphoid tissues and morphologic changes in the liver were associated with the dietary protein utilization. Protein and vitamin A deficiency generated significant stimulation of the Interleukin 1 expression gene with increase of the level of the inflammatory state indicators as serum alpha protein, total complement and neutrophils. This stimulation could be generated by a deficient retinol mobilization to tissues. These results support the hypothesis of the function of cytokines as mediators of subclinical symptoms of the immune system during the nutritional affectations.
authors.affiliation: Departamento de Bioquímica y Fisiología Instituto de Nutrición e Higiene de los Alimentos-Cuba.
authors.forename: Vivian
authors.initials: V
authors.lastname: Sánchez Alvarez
authors.forename: Manuel
authors.initials: M
authors.lastname: Hernández Triana
authors.forename: Mario
authors.initials: M
authors.lastname: Abreu Peñate
authors.forename: Ada
authors.initials: A
authors.lastname: de las Cagigas Reig
authors.forename: Miguel
authors.initials: M
authors.lastname: Tam Hurtado
authors.forename: José
authors.initials: J
authors.lastname: Reboso Pérez
authors.forename: Miriam
authors.initials: M
authors.lastname: Noa Puig
authors.forename: José
authors.initials: J
authors.lastname: Arias Verdé
authors.forename: Rebeca
authors.initials: R
authors.lastname: Fernández Carriera
authors.forename: Soraya
authors.initials: S
authors.lastname: González Calderín
authors.forename: Antonio
authors.initials: A
authors.lastname: Sigarroa González
mesh_terms: D000818:Animals; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage; D004195:Disease Models, Animal; D004435:Eating; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D009752:Nutritional Status; D011488:Protein Deficiency / Q000235:genetics / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014801:Vitamin A / Q000097:blood / Q000378:metabolism; D014802:Vitamin A Deficiency / Q000235:genetics / Q000276:immunology*
chemical_list: D004044:Dietary Proteins; D007375:Interleukin-1; D014801:Vitamin A