The interplay of dendritic cell subsets in systemic lupus erythematosus.
Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.
Palucka
A Karolina
AK
Baylor Institute for Immunology Research and University of Texas Southwestern Medical Center, Dallas 75204, USA. karolinap@baylorhealth.edu
Banchereau
Jacques
J
Blanco
Patrick
P
Pascual
Virginia
V
D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology; D039521:CD11c Antigen / Q000032:analysis; D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D016898:Interferon-alpha / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D018448:Models, Immunological; D022423:Myeloid Cells / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology
D001323:Autoantibodies; D039521:CD11c Antigen; D016207:Cytokines; D016898:Interferon-alpha