[A case with secondary hyperparathyroidism suggesting the direct suppressive effect of maxacalcitol on osteoblasts].
The direct effect of vitamin D on osteoblasts in secondary hyperparathyroidism(2 degrees HPT) is not necessarily obvious. We found an unusual hemodialyzed patient without any response to oral calcitriol pulse therapy(4 micrograms x 2/week), and who was administered maxacalcitol at a dose of up to 15 micrograms x 3/week for 28 months. Plasma intact parathyroid hormone(PTH) was not suppressed from the initial level of 1,773 pg/ml to 2,100 pg/ml. However, on the contrary, alkaline phosphatase(ALP) was successively suppressed from 2 weeks from the initial level of 1,261 IU/l to 276 IU/l. This result suggests a direct suppressive effect of maxacalcitol on osteoblasts in 2 degrees HPT.
Shiota
Jun
J
Department of Internal Medicine, Urayasu-Ichikawa City Hospital, Japan.
Tanaka
Araki
A
D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000097:blood; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010006:Osteoblasts / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002117:Calcitriol; C051883:maxacalcitol