Optical imaging of glycinergic inhibition in the vestibular and cochlear nuclei.
Using multiple-site optical recording techniques, the spatiotemporal activity was observed in both the cochlear and vestibular nucleus in newborn mice. The optical responses were obviously enhanced by bath-applied strychnine. A quantitative analysis showed higher enhancements to occur in the cochlear nucleus than in the vestibular nucleus. Optical imaging enables us to visualize the spatiotemporal extent of the inhibitory receptive field after the application of strychnine.
Yang
Shi-Ming
SM
Department of Otolaryngology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi, Osaka 570-8507, Japan.
Doi
Tadashi
T
Jing
Shen
S
Kaneko
Toshihiko
T
Matsumoto-Ono
Ayumi
A
Asako
Mikiya
M
Yamashita
Toshio
T
D000818:Animals; D000831:Animals, Newborn; D017626:Cochlear Nucleus / Q000187:drug effects / Q000502:physiology*; D003952:Diagnostic Imaging; D005998:Glycine / Q000502:physiology*; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014726:Vestibular Nuclei / Q000187:drug effects / Q000502:physiology*
D013331:Strychnine; D005998:Glycine