title: Placental transfer of ganciclovir in a woman with acquired immunodeficiency syndrome and cytomegalovirus disease.
abstract: A pregnant woman with AIDS developed cytomegalovirus (CMV) retinitis and pneumonitis, requiring intravenous ganciclovir. At 34 weeks gestation the woman delivered a 1.4-kg girl. Examination of the placenta revealed transplacental passage of CMV. Low concentrations of ganciclovir were detected in the neonate's plasma. The neonate had mild anemia but no other signs of congenital CMV infection.
authors.affiliation: Department of Pediatrics Cincinnati Children's Hospital Medical Center, Cincinati, OH, USA.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Brandy
authors.forename: Mark R
authors.initials: MR
authors.lastname: Schleiss
authors.forename: David P
authors.initials: DP
authors.lastname: Witte
authors.forename: Tariq A
authors.initials: TA
authors.lastname: Siddiqi
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fame
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000998:Antiviral Agents / Q000097:blood / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000150:complications / Q000188:drug therapy* / Q000635:transmission; D005260:Female; D015774:Ganciclovir / Q000097:blood* / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir