Human herpesvirus 6 and multiple sclerosis: a study of T cell cross-reactivity to viral and myelin basic protein antigens.
Several reports have suggested an association of human herpesvirus 6 (HHV-6) with multiple sclerosis. Autoreactive T lymphocytes directed against myelin components seem to contribute to the pathogenesis of the disease. It has been suggested that molecular mimicry between viral and self-antigens might be one of the mechanisms that determine the onset of several autoimmune diseases. Following this hypothesis, the purpose of the present study was to evaluate if HHV-6 could play a role in activating T cells capable of cross-reaction with an important myelin component, the myelin basic protein. T cell lines were established from 22 multiple sclerosis patients and from 16 healthy controls, and their capability to react to both virus and myelin basic protein antigens was compared. The analysis of T cell cross-reactivity in patients and controls did not show significant differences in the HHV-6 ability to activate myelin basic protein-reactive T cells. Similarly, the evaluation of the humoral immune response to HHV-6 in patients and controls did not mirror any abnormality in the HHV-6 status in multiple sclerosis patients. Therefore, although the findings of activity in vitro of T cell lines with dual specificity are consistent with the hypothesis of molecular mimicry, the lack of differences in cross-reactivity between patients and controls do not support molecular mimicry as an important mechanism in the physiopathology of this disease.
Cirone
Mara
M
Dipartimento di Medicina Sperimentale e Patologia, Università La Sapienza, Roma, Italy.
Cuomo
Laura
L
Zompetta
Claudia
C
Ruggieri
Stefano
S
Frati
Luigi
L
Faggioni
Alberto
A
Ragona
Giuseppe
G
D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral; D015551:Autoimmunity; D016022:Case-Control Studies; D002460:Cell Line; D003429:Cross Reactions; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D018448:Models, Immunological; D018716:Molecular Mimicry; D009103:Multiple Sclerosis / Q000209:etiology* / Q000276:immunology / Q000821:virology; D004676:Myelin Basic Protein / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000956:Antigens, Viral; D004676:Myelin Basic Protein