title: Fructose prefeeding reduces the glycemic response to a high-glycemic index, starchy food in humans.
abstract: The study objective was to determine whether a small dose of fructose administered before or simultaneously with a high glycemic index, starchy food decreases postprandial glycemic response. Nondiabetic healthy adults (n = 31; mean +/- SEM: age, 26 +/- 1 y; weight, 66.1 +/- 2.6 kg; body mass index, 23.3 +/- 0.6 kg/m(2)) were studied in a randomized crossover design. Treatments consisted of 50 g available carbohydrate from instant mashed potatoes fed alone (control) or with 10 g fructose fed 60, 30 or 0 min before the potato meal. Capillary finger-stick blood samples were analyzed for glucose concentration at -60, -30, 0, 15, 30, 45, 60, 90 and 120 min relative to the ingestion of the potato meal. Compared with the control, the positive incremental area under the glucose curve was reduced 25 and 27% (P < 0.01) when fructose was fed either 60 or 30 min before the meal, respectively. In contrast to previous studies demonstrating that immediate administration of a small amount of fructose lowers the glycemic response to a glucose solution, we found that fructose must be consumed before a starchy food to reduce postprandial glycemia.
authors.affiliation: School of Allied Medical Professions-Medical Dietetics Division, The Ohio State University, Columbus, OH 43210-1234, USA. heacock.13@osu.edu
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Heacock
authors.forename: Steven R
authors.initials: SR
authors.lastname: Hertzler
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Wolf
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D005260:Female; D005632:Fructose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D019518:Postprandial Period; D011198:Solanum tuberosum; D013213:Starch / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005632:Fructose; D013213:Starch