Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin a, a new antitumor macrolide lactam from the sponge poecillastra species.
Poecillastrin A (1), a new polyketide-derived macrolide lactam, was isolated from a deep-water collection of the marine sponge Poecillastra species. The structure of poecillastrin A (1) was assigned using NMR data acquired at 500 MHz with an inverse-detection cryogenic probe and at 800 MHz with a room-temperature probe.
Rashid
Mohammad A
MA
Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
Gustafson
Kirk R
KR
Crouch
Ronald C
RC
Groweiss
Amiram
A
Pannell
Lewis K
LK
Van
Que N
QN
Boyd
Michael R
MR
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D003080:Cold Temperature; D007769:Lactams / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents; D007769:Lactams; D018942:Macrolides; C467924:poecillastrin A