Increased aquaporin 1 water channel expression in human brain tumours.
Aquaporin 1 is a water channel protein. There was little aquaporin 1 immunoreactivity in normal brain parenchyma. In astrocytomas, aquaporin 1 was expressed in microvessel endothelia and neoplastic astrocytes. In metastatic carcinomas, aquaporin 1 was present in microvessel endothelia and reactive astrocytes. Aquaporin 1 may participate in the formation of brain tumour oedema.
Saadoun
S
S
Department of Infectious Diseases, St. George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK.
Papadopoulos
M C
MC
Davies
D C
DC
Bell
B A
BA
Krishna
S
S
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D051398:Aquaporin 1; D020346:Aquaporins / Q000378:metabolism*; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D001254:Astrocytoma / Q000378:metabolism* / Q000473:pathology; D001789:Blood Group Antigens; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001929:Brain Edema / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D015972:Gene Expression Regulation, Neoplastic; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008833:Microcirculation / Q000473:pathology; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D011379:Prognosis; D015854:Up-Regulation
C496020:AQP1 protein, human; D020346:Aquaporins; D001789:Blood Group Antigens; D005904:Glial Fibrillary Acidic Protein; D051398:Aquaporin 1