Reversible hemiparesis associated with the use of topiramate.
We report a case of a 5-year-old boy with intractable partial seizures who developed a transient hemiparesis, worsening of the electroencephalogram (EEG) and a change in his seizure pattern with increased seizure frequency after receiving topiramate (TPM). Symptoms resolved within a month after TPM was discontinued. Clinicians need to be aware that TPM use may occasionally be associated with focal motor weakness and exacerbation of seizures.
Patel
Hema
H
Section of Child Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Asconapé
Jorge J
JJ
Garg
Bhuwan P
BP
D000927:Anticonvulsants / Q000009:adverse effects*; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy*; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D010291:Paresis / Q000139:chemically induced* / Q000175:diagnosis; D012720:Severity of Illness Index; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose