title: Sense and sensibility in the regulation of voltage-gated Ca(2+) channels.
abstract: Voltage-gated Ca(2+) channels are crucial for neurotransmitter release and other neuronal functions, and their activity-dependent regulation could underlie various aspects of synaptic plasticity. Recent studies have identified Ca(2+)-sensing proteins involved in Ca(2+)-channel modulation. These have complex effects on channel gating, and data suggest that the actions of multiple Ca(2+) sensors are important for the fine-tuning of Ca(2+) channel activity.
authors.affiliation: The Physiological Laboratory, University of Liverpool, UK.
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Weiss
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burgoyne
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D015640:Ion Channel Gating / Q000502:physiology; D009474:Neurons / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D002135:Calcium-Binding Proteins