title: Stimulated cortisol secretion is not correlated with prednisone dose or with steroid side-effects in children after renal transplantation.
abstract: Impairment of adrenocortical function and other adverse effects have to be considered whenever corticosteroids are applied for a prolonged period of time. We hypothesized that the assessment of adrenal function with adrenocortiocotropin (ACTH) stimulation reflects the sensitivity to corticosteroids and would predict the development of side-effects in pediatric patients on triple immunosuppression after renal transplantation.
authors.affiliation: Departments of Pediatrics and Surgery, Philipps-University, Marburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Revermann
authors.forename: M
authors.initials: M
authors.lastname: Soergel
authors.forename: A
authors.initials: A
authors.lastname: Hellinger
authors.forename: G
authors.initials: G
authors.lastname: Klaus
mesh_terms: D000293:Adolescent; D000309:Adrenal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone; D000328:Adult; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D012044:Regression Analysis; D018709:Statistics, Nonparametric
chemical_list: D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D011241:Prednisone; D006854:Hydrocortisone