[Influence of human cytomegalovirus infection on the expression of HOX genes in human embryo lung cells].
The expressions of HOX genes in human embryo lung (HEL) cells were detected with semi-quantitative RT-PCR method. The results were that HEL cells expressed HOXB7 gene and its expression increased after human cytomegalovirus (HCMV) infection. The level of expression reached maximum at 48 h after HCMV infection. Treated with all-trans retinoic acid (ATRA), the expression of HOXB7 in HEL cells infected by HCMV was significantly increased. The results suggest that the abnormal expression of HOX genes induced by HCMV might possibly play a role in virus-induced abnormal embryogenesis.
Chen
L Y
LY
Department of Microbiology, Hunan Medical University, Changsha 410078.
Dai
G
G
Wu
G J
GJ
Wang
J W
JW
Luo
M H
MH
Chen
S Z
SZ
D002478:Cells, Cultured; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000235:genetics*; D004622:Embryo, Mammalian; D015870:Gene Expression; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008168:Lung / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018398:Homeodomain Proteins