In vitro activities of newer quinolones against bacteroides group organisms.
The activities of BMS-284576, clinafloxacin, moxifloxacin, sitafloxacin, trovafloxacin, imipenem, cefoxitin, and clindamycin against 589 Bacteroides fragilis group isolates were determined. The activity of BMS-284576 was comparable to that of trovafloxacin. Sitafloxacin and clinafloxacin were the most active quinolones, and moxifloxacin was the least active. B. fragilis was the most susceptible of the species, and Bacteroides vulgatus was the most resistant. Association of specific antibiotic resistance with Bacteroides species was noted for all quinolones.
Snydman
D R
DR
Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. dsnydman@lifespan.org
Jacobus
N V
NV
McDermott
L A
LA
Ruthazer
R
R
Goldstein
E
E
Finegold
S
S
Harrell
L
L
Hecht
D W
DW
Jenkins
S
S
Pierson
C
C
Venezia
R
R
Rihs
J
J
Gorbach
S L
SL
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D001439:Bacteroides / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones; D006801:Humans; D007211:Indoles; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology; D011804:Quinolines; D015363:Quinolones
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D007211:Indoles; D009287:Naphthyridines; D011804:Quinolines; D015363:Quinolones; C057477:clinafloxacin; C080163:trovafloxacin; C076246:sitafloxacin; D000077266:Moxifloxacin; C419689:garenoxacin