Location, location, location: translational control in development and neurobiology.
Control of gene expression by regulating mRNA translation is essential for proper growth and development in species ranging from yeast to mammals. Recently, translational regulation has also been implicated in neuronal function, where long-lasting changes in synaptic strength and the formation of memory require new protein synthesis. Crucial to both developmental and neurobiological function, translational control allows for the asymmetric distribution of gene products and a rapid and local response to stimulation--as discussed at a recent Serono Foundation EMBO Workshop held in Mallorca, Spain.
Méndez
Raúl
R
Center for Genomic Regulation (CRG). Program of Gene Expression. Passeig Maritim 37-49, 08003, Barcelona, Spain. raul.mendez@crg.es
Wells
David
D
D000818:Animals; D004331:Drosophila melanogaster / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D007814:Larva / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism
D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators