Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
Fifty-eight curcumin analogues were prepared and evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Compound was the most potent analogue against several cell lines, including HOS (bone cancer) and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 microg/mL, respectively.
Ishida
Junko
J
Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo, Japan.
Ohtsu
Hironori
H
Tachibana
Yoko
Y
Nakanishi
Yuka
Y
Bastow
Kenneth F
KF
Nagai
Masahiro
M
Wang
Hui-Kang
HK
Itokawa
Hideji
H
Lee
Kuo-Hsiung
KH
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006865:Hydrogenation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D003474:Curcumin