Results of peritoneal equilibration test during treatment with polyglucose dialysis solution.
BACKGROUND
Results of peritoneal equilibration test (PET) suggest prolonged effect of polyglucose dialysis solution (PG-DS) on peritoneal permeability.


OBJECTIVE
An evaluation of dialysate-to-plasma ratio (D/P) of urea, DIP creatinine, and D/D0 glucose (ratio of dialysate glucose at designated dwell time to dialysate glucose at 0 dwell time), and mass transfer area coefficients (KBD) of these solutes in PET before introduction, during administration, and after discontinuation of PG-DS hi patients treated with continuous ambulatory peritoneal dialysis (CAPD).


METHODS
Single-center prospective study with PG-DS; retrospective selection of the control group.


METHODS
Peritoneal dialysis unit in a university hospital.


METHODS
Fourteen patients (11 males; age 45.1 +/- 8.5 years) treated with CAPD for 17.5 +/- 9.9 months. 7.5% PG-DS was used for the overnight exchange. After discontinuation of the PG-DS, standard dialysis solutions, as previously used, were reintroduced. The control group was selected to match both CAPO duration and peritoneal permeability of the patients in the PG-DS group at the start of the study.


METHODS
Standard PET was carried out at 1.6 +/- 0.8 months before the introduction of PG-DS (study period I, n = 14), after 1.2 +/- 0.6 months' use of PG-DS (study period II, n = 14), after 4.4 +/- 0.8 months' use of PG-DS (study period Ill, n = 11), after 8.8 +/- 2.2 months' use of PG-DS (study period IV, n = 9), and at 2.0 +/- 0.6 months after PG-DS discontinuation (study period V, n = 11). Patients in the control group underwent PET at similar time intervals (control periods I-V).


RESULTS
In the PG-DS group, a tendency toward increased peritoneal permeability for urea and creatinine was shown during the consecutive study periods. D/D0 glucose was significantly higher only in the PET performed during use of PG-DS (periods II-IV) compared to results obtained in period I. In the control group, both D/P and KBD of both urea and creatinine remained unchanged, but K90 glucose was higher in the first 2 hours of the PET in control period V compared to respective values in control period III.


CONCLUSIONS
Changes in peritoneal permeability are observed In CAPD patients treated with PG-DS. These changes may be at least partially related to the administration of polyglucose.
Grzegorzewska
Alicja E
AE
Antczak-Jedrzejczak
Danuta
D
Leander
Magdalena
M
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000097:blood; D015314:Dialysis Solutions / Q000032:analysis / Q000493:pharmacokinetics*; D005260:Female; D005936:Glucans / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000187:drug effects* / Q000503:physiopathology*; D010539:Permeability / Q000187:drug effects*; D011446:Prospective Studies; D013997:Time Factors; D014508:Urea / Q000097:blood; D014511:Uremia / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*
D001786:Blood Glucose; D015314:Dialysis Solutions; D005936:Glucans; D014508:Urea; D003404:Creatinine