Sense and sensibility in the regulation of voltage-gated Ca(2+) channels.
Voltage-gated Ca(2+) channels are crucial for neurotransmitter release and other neuronal functions, and their activity-dependent regulation could underlie various aspects of synaptic plasticity. Recent studies have identified Ca(2+)-sensing proteins involved in Ca(2+)-channel modulation. These have complex effects on channel gating, and data suggest that the actions of multiple Ca(2+) sensors are important for the fine-tuning of Ca(2+) channel activity.
Weiss
Jamie L
JL
The Physiological Laboratory, University of Liverpool, UK.
Burgoyne
Robert D
RD
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D015640:Ion Channel Gating / Q000502:physiology; D009474:Neurons / Q000378:metabolism
D015220:Calcium Channels; D002135:Calcium-Binding Proteins