Regulation of viral transcription elongation and termination during vaccinia virus infection.
Vaccinia virus provides a useful genetic and biochemical tool for studies of the basic mechanisms of eukaryotic transcription. Vaccinia genes are transcribed in three successive gene classes during infection, early, intermediate, and late. Vaccinia transcription is regulated primarily by virus gene products not only during initiation, but also during elongation and termination. The factors and mechanisms regulating early elongation and termination differ from those regulating intermediate and late gene expression. Control of transcription elongation and termination in vaccinia virus bears some similarity to the same process in other prokaryotic and eukaryotic systems, yet features some novel mechanisms as well.
Condit
Richard C
RC
Department of Molecular Genetics and Microbiology, P.O. Box 100266, University of Florida, Gainesville, FL 32610, USA. condit@mgm.ufl.edu
Niles
Edward G
EG
D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D009713:Nucleotidyltransferases / Q000378:metabolism; D010441:Peptide Chain Elongation, Translational; D010443:Peptide Chain Termination, Translational; D014158:Transcription, Genetic; D014615:Vaccinia / Q000235:genetics*; D014616:Vaccinia virus / Q000235:genetics* / Q000378:metabolism; D000098556:mRNA Guanylyltransferases
D009713:Nucleotidyltransferases; D000098556:mRNA Guanylyltransferases; D012321:DNA-Directed RNA Polymerases