[Correlative study on HLA-DR2 allelic polymorphism and systemic lupus erythematosus in the Han nationality in Hunan province].
Fifty-eight systemic lupus erythematosus (SLE) patients and 59 normal controls of the Han nationality in Hunan province were involved in this study to analyze the correlation between HLA-DR2 group specific amplification in combination with HLA-DRB generic amplification PCR/SSCP technique to detect the sequence variation within exon 2 of HLA-DR2 alleles outside the sequence specific primer matching positions. The results were that HLA-DR2 was strongly correlated with SLE (RR = 2.71, P < 0.01); and HLA-DRB1 * 1501 was the allele correlated with disease (RR = 3.01, Pc < 0.05). In addition, PCR/SSCP showed that there was not any novel sequence variation in exon 2 of HLA-DR2 alleles in the Han nationality in Hunan province.
Tian
W
W
Immunology Research Laboratory, Hunan Medical University, Changsha 410078.
Li
L X
LX
Guo
S S
SS
D000483:Alleles; D044466:Asian People; D002681:China; D005006:Ethnicity; D005091:Exons; D015802:HLA-DR2 Antigen / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational
D015802:HLA-DR2 Antigen