Angiotensin-converting enzyme gene polymorphism and coronary heart disease in Turkish type 2 diabetic patients.
OBJECTIVE
It has been suggested that the insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) may be associated with atherosclerosis. The aim of the study was to examine the association between ACE gene polymorphism and coronary heart disease in Turkish type 2 diabetic patients.


RESULTS
A total of 152 (97 female, 55 male) type 2 diabetic patients were included into the study. All patients underwent myocardial perfusion scintigraphic examination and forty-five of them with a perfusion defect underwent coronary angiography.Thirty-eight patients with a coronary stenosis of more than 50% on coronary angiography were considered as having coronary heart disease. The I/D polymorphism was determined by polymerase chain reaction. There was no statistically significant difference in genotypic and allelic frequencies of the ACE I/D polymorphism among patients with and without coronary heart disease (DD:ID:II (%), 32:58:11 and 39:44:17, respectively).


CONCLUSIONS
ACE gene polymorphism is not a significant parameter to determine coronary heart disease in Turkish type 2 diabetic patients.
Araz
Mustafa
M
Department of Internal Medicine, Medical Faculty, Gaziantep University, Turkey. araz@gantep.edu.tr
Aynacioglu
Sükrü
S
Okan
Vahap
V
Akdemir
Ilyas
I
Aktaran
Sebnem
S
D003327:Coronary Disease / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D014421:Turkey
D007703:Peptidyl-Dipeptidase A