title: Practical asymmetric synthetic route to 4,4,4-trifluoro-3-hydroxybutyrate: head-to-tail and head-to-head crystallizations through double and single hydrogen bonds of hetero- and homochiral 4,4,4-trifluoro-3-hydroxybutyrophenones.
abstract: A practical asymmetric synthetic route to 4,4,4-trifluoro-3-hydroxybutyrophenone and the butyric acid phenyl ester is described using heterochiral crystallization through double hydrogen bonding assembly in head-to-tail fashion and sequential Baeyer-Villiger oxidation reaction by trifluoroperacetic acid.
authors.affiliation: Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ishii
authors.forename: Masatomi
authors.initials: M
authors.lastname: Kanai
authors.forename: Kimio
authors.initials: K
authors.lastname: Higashiyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Mikami