[Endothelium-dependent contractile reactions of vascular smooth muscles and content of oxygen free radicals in aging rats].
Endothelium-dependent and endothelium-independent reactions of vascular smooth muscles were studied in isolated preparations of thoracic part of aorta and portal vein of rats of two age groups--6.8 mo. (control) and 24-26 mo. (old animals). In old rats the disturbances occurred primarily in endothelium-dependent vascular reactions. This age-related dysfunction of endothelium resulted in inhibition of NO-dependent regulation of vascular tone. Age-related changes in the state of plasmic membranes of erythrocytes were established using a method of acid hemolysis. Age-related changes in the levels of active forms of oxygen (.O2-, H2O2, .OH-) and nitrogen (NO2-, NO3-) were determined in the myocardium, aorta, blood plasma and erythrocytes of adult and old animals.
Tkachenko
M M
MM
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Sahach
V F
VF
Kotsiuruba
A V
AV
Baziliuk
O V
OV
Bukhanevych
O M
OM
Mehed'
O F
OF
Stepanenko
L H
LH
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D009569:Nitric Oxide / Q000096:biosynthesis*; D011169:Portal Vein / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D014661:Vasoconstriction / Q000502:physiology*
D005609:Free Radicals; D009569:Nitric Oxide