title: [Studies on antitussive, antiasthmatic, expectorant and anti-inflammatory effects of Jin'an kechuan granules].
abstract: OBJECTIVE
  To study the pharmacologic effect of Jin'an Kechuan granules.
  
  
  METHODS
  Routine antitussive, antiasthmatic and expectorant methods were used.
  
  
  RESULTS
  Jin'an Kechuan granules in the doses of 16, 8, 4 g.kg-1 ig could significantly decrease the frequency of cough caused by ammonia water in mice, and increase the secretion of phenol red from mouse tracheas in a dose-dependent manner. The granules also help increase the threshold voltage to induce cats to cough, prolong the latent period of asthma induced by histamine and acetylcholine mixture, and antagonize the contraction of isolated trachea strips induced by histamine and acetylcholine in guinea pigs. Jin'an Kechuan granules had inhibitory effects on common bacteria in the respiratory tract as well as on the swelling of acute inflammation in mice and rats.
  
  
  CONCLUSIONS
  Jin'an Kechuan granules have antitussive, antiasthmatic, expectorant and anti-inflammatory, antibacterial effects.
authors.affiliation: Department of Pharmacology, Anhui College of TCM, Anhui, Hefei 230038, China.
authors.forename: G L
authors.initials: GL
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: Q M
authors.initials: QM
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: H J
authors.initials: HJ
authors.lastname: Cheng
authors.forename: L
authors.initials: L
authors.lastname: Han
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000996:Antitussive Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy; D002415:Cats; D003371:Cough / Q000188:drug therapy; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005100:Expectorants / Q000627:therapeutic use*; D006168:Guinea Pigs; D051379:Mice; D008517:Phytotherapy; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D018927:Anti-Asthmatic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000996:Antitussive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005100:Expectorants