[Effect of qingkailing on glutamate and NMDA receptor of brain tissue].
The effects of QingKaiLing on the content of glutamate(Glu) and gamma-aminobutyric acid(GABA), and the numbers and affinity of N-methyl-D-aspartate (NMDA) receptor in brain tissue were observed. QingKaiLing did not change the content of Glu and GABA and the ratio of Glu/GABA in brain tissue (P > 0.05). The numbers of NMDA receptor on membrane of neuron were significantly decreased in QingKaiLing group(P < 0.05). These results suggested that the brain protective mechanism of QingKaiLing be in relation to decreasing the numbers of NMDA receptor.
Yue
S J
SJ
Department of Pediatrics, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Chen
J F
JF
Tao
Y G
YG
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid