title: Principles of clinical trial design.
authors.affiliation: Princess Margaret Hospital, University Health Network, 610 University Ave, Toronto, Ontario M5G 2M9, Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Nottage
authors.forename: Lillian L
authors.initials: LL
authors.lastname: Siu
mesh_terms: D002986:Clinical Trials as Topic; D004992:Ethics, Medical; D006801:Humans; D017410:Practice Guidelines as Topic; D015203:Reproducibility of Results; D012107:Research Design