title: Monoclonal rearrangement of the T cell receptor gamma-chain in lichenoid pigmented purpuric dermatitis of gougerot-blum responding to topical corticosteroid therapy.
abstract: Lichenoid pigmented purpuric dermatitis of Gougerot-Blum belongs to a group of closely related disorders which are termed pigmented purpuric dermatoses. It clinically manifests itself with grouped lichenoid papules in association with purpuric lesions. We report a case of lichenoid pigmented purpuric dermatitis of Gougerot-Blum with a heavy band-like CD4-positive lymphocytic infiltrate and clonal rearrangements of the gamma-chain of the T cell receptors as detected by polymerase chain reaction/denaturing gradient gel electrophoresis. Monoclonal expansion of T cells in combination with certain histological features of mycosis fungoides (MF) might support a biological relationship between lichenoid pigmented purpuric dermatitis of Gougerot-Blum and MF. However, prompt clinical response to topical steroid therapy supports the benign clinical nature of our case.
authors.affiliation: Department of Dermatology, University Hospital, Zurich, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Lor
authors.forename: U
authors.initials: U
authors.lastname: Krueger
authors.forename: W
authors.initials: W
authors.lastname: Kempf
authors.forename: G
authors.initials: G
authors.lastname: Burg
authors.forename: F O
authors.initials: FO
authors.lastname: Nestle
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D002999:Clone Cells; D004586:Electrophoresis; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D005938:Glucocorticoids; D006801:Humans; D017512:Lichenoid Eruptions / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D010859:Pigmentation Disorders / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D016133:Polymerase Chain Reaction; D011693:Purpura / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D002990:Clobetasol