title: Prevalence of hepatitis C Virus infection among hemophiliacs in Central Brazil.
abstract: In order to investigate the hepatitis C virus (HCV) infection prevalence and risk factors in hemophiliacs in Central Brazil, 90 patients were interviewed and serum samples tested for HCV RNA and anti-HCV antibodies. An overall prevalence of 63.3% (CI 95%: 53.0-72.7) was found. Multivariate analysis of risk factors showed that number of blood transfusions was significantly associated with this infection. Most hemophiliacs received locally produced cryoprecipitate. All infected patients were transfused before the screening of blood units for anti-HCV. However, hemophiliacs who received exclusively screened cryoprecipitate were HCV negative. It confirms the expected decline in transfusion-acquired hepatitis C.
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, 74605-050, Brasil. rbringel@terra.com.br
authors.forename: Adriana P
authors.initials: AP
authors.lastname: Barbosa
authors.forename: Regina M B
authors.initials: RM
authors.lastname: Martins
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Teles
authors.forename: Simonne A
authors.initials: SA
authors.lastname: Silva
authors.forename: Jaqueline M
authors.initials: JM
authors.lastname: Oliveira
authors.forename: Clara F T
authors.initials: CF
authors.lastname: Yoshida
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D004797:Enzyme-Linked Immunosorbent Assay; D006467:Hemophilia A / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D018937:Hepatitis C Antibodies; D012367:RNA, Viral