title: Effects of intravenous triiodothyronine during coronary artery bypass surgery.
abstract: A prospective randomized and double-blind study was performed to evaluate whether perioperative triiodothyronine administration has any effect on cardiovascular performance after coronary artery bypass surgery. Sixty patients were assigned to 2 groups of 30 each. When crossclamping ended, group A received an intravenous bolus of triiodothyronine, followed by infusion for 6 hours. Group B received a placebo. Serum triiodothyronine levels and hemo-dynamic parameters were serially measured. Mean postoperative cardiac index was slightly, but not significantly, higher in group A, whereas systemic vascular resistance was significantly lower in group A. Compared with preoperative values, serum triiodothyronine levels dropped significantly in group B at the end of cardiopulmonary bypass and remained low 12 hours postoperatively, while levels rose significantly in group A. No significant differences were detected between the groups in the incidence of arrhythmia, the need for inotropic support, intensive care unit stay, mortality, and morbidity. Perioperative administration of triiodothyronine increased cardiac output slightly and decreased systemic vascular resistance, but it had no effect on operative outcome. Routine use after coronary surgery is thus not recommended.
authors.affiliation: Department of Cardiovascular Surgery Kadir Has University, Florence Nightingale Hospital Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Güden
authors.forename: Belhhan
authors.initials: B
authors.lastname: Akpinar
authors.forename: Ertan
authors.initials: E
authors.lastname: Sagğbaş
authors.forename: Ilhan
authors.initials: I
authors.lastname: Sanisoğlu
authors.forename: Emine
authors.initials: E
authors.lastname: Cakali
authors.forename: Osman
authors.initials: O
authors.lastname: Bayindir
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D019990:Perioperative Care; D011183:Postoperative Complications; D011446:Prospective Studies; D014284:Triiodothyronine / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014284:Triiodothyronine