Biodegradable polymeric nanospheres formed by temperature-induced phase transition in a mixture of poly(lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer.
The mixture of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer(F-127) and PLGA (poly(lactide-co-gycolide)) forms a liquid state above their phase transition temperatures, and the phase-separated state is induced by decreasing the temperature below the phase transition temperature. On the basis of the temperature-induced phase transition behavior in the mixture of F-127 and PLGA, a novel method for the preparation of drug-loaded PLGA nanospheres was designed and characterized by measuring the loading amount, the encapsulation efficiency, and the drug release pattern. Paclitaxel, used as a potent anticancer drug, was selected as a model drug.
Lee
Ka Eul
KE
Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon 306-791, Korea.
Kim
Byoung Ki
BK
Yuk
Soon Hong
SH
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001673:Biodegradation, Environmental; D003956:Dialysis; D004337:Drug Carriers / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry; D008863:Microspheres; D036103:Nanotechnology; D017239:Paclitaxel / Q000008:administration & dosage / Q000493:pharmacokinetics; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D013696:Temperature
D000970:Antineoplastic Agents; D004337:Drug Carriers; C116176:PEO-PPO-PEO; D011108:Polymers; D011409:Propylene Glycols; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D017239:Paclitaxel