title: Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.
abstract: Some benzimidazolyl sulphones were synthesized and evaluated for their antiviral and antiproliferative properties. Compound 10 displayed significant and selective activity against human cytomegalovirus (CMV), compound 14 showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives. Some structure-activity relationships are discussed.
authors.affiliation: Department of Pharmaceutical Science, University of Bologna, via Belmeloro 6, I-40126 Bologna, Italy. lauga@alma.unibo.it
authors.forename: Laura
authors.initials: L
authors.lastname: Garuti
authors.forename: Marinella
authors.initials: M
authors.lastname: Roberti
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D051379:Mice; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects; D014407:Tumor Cells, Cultured; D010948:Viral Plaque Assay
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001562:Benzimidazoles