[Population genetics and medicine].
The paper covers several topics that demonstrate a close relationship between population genetics and medicine. To study isolated populations is an effective tool to detect "new" Mendelian diseases and to map the genes of hereditary diseases. Several new molecular genetic techniques have been developed, which facilitates the procedure of gene mapping. New genetic polymorphisms, such as VNTR, STR, and SNP in particular, have increased the feasibility of searching for genes, which predisposes to common diseases through linkage mapping and association studies. DNA polymorphisms have been shown to be also effective in solving the problems of pharmacological genetics and for detecting genes whose variability is associated with the efficacy of drugs and their side effects.
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D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005828:Genetics, Population / Q000639:trends*; D006801:Humans; D010597:Pharmacogenetics / Q000639:trends; D011110:Polymorphism, Genetic