Modelling the response of scalp sensory receptors to transcranial electrical stimulation.
Transcranial electrical stimulation of the brain causes considerable discomfort to the patient. The purpose of the study was to find out whether this could be affected by the choice of stimulation parameters. A spherical volume conductor model of the head and active compartmental models of a pyramidal motor nerve and scalp nociceptor were used in combination to simulate the scalp nociception to transcranial electrical stimulation. Scalp nociceptors were excited at distances of several centimetres from the electrodes. The size of the excited scalp area correlated with the length of the stimulation pulse. The area was 12.3, 20.4 and 26.0 cm2, for a 10 micros, 100 micros and 1 ms constant current pulse, respectively. With a 100 micros constant current pulse, the threshold for motor excitation was 205mA and, for nociception, it was 51 mA. There was no significant difference between constant current and capacitor discharge pulses or between electrodes of different sizes. The results imply that the use of very short stimulation pulses can reduce the pain. If a topical anaesthesia is used to reduce the pain, it has to be applied on a large area around the electrodes.
Suihko
V
V
Department of Clinical Neurophysiology, Tampere University Hospital, Finland. Veikko.Suihko@epshp.fi
D003198:Computer Simulation; D004558:Electric Stimulation / Q000009:adverse effects / Q000379:methods*; D019054:Evoked Potentials, Motor; D006801:Humans; D008959:Models, Neurological; D010146:Pain / Q000517:prevention & control; D012535:Scalp / Q000294:innervation*; D011984:Sensory Receptor Cells / Q000502:physiology*