Natural killer cells and pregnancy.
The fetus is considered to be an allograft that, paradoxically, survives pregnancy despite the laws of classical transplantation immunology. There is no direct contact of the mother with the embryo, only with the extraembryonic placenta as it implants in the uterus. No convincing evidence of uterine maternal T-cell recognition of placental trophoblast cells has been found, but instead, there might be maternal allorecognition mediated by uterine natural killer cells that recognize unusual fetal trophoblast MHC ligands.
Moffett-King
Ashley
A
Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK. am485@cam.ac.uk
D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D023421:Models, Animal; D010920:Placenta / Q000166:cytology / Q000276:immunology*; D010929:Placentation / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D014181:Transplantation Immunology; D014327:Trophoblasts / Q000166:cytology / Q000276:immunology; D014599:Uterus / Q000098:blood supply / Q000276:immunology*