title: Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes.
abstract: OBJECTIVE
  The current therapeutic strategies to reduce macrosomia rates in gestational diabetes (GDM) have focused on the normalizing of maternal glucose levels. The aim of our study was 1.) to compare maternal glycemic values with the presence of fetal macrosomia at different gestational ages (GA) and with LGA at birth in a cohort of women with glucose intolerance and standard diabetic therapy.
  
  
  METHODS
  306 women with GDM and 97 with impaired glucose tolerance underwent ultrasound examinations at entry and, after initiation of therapy, monthly in addition to standard diabetic therapy. Measurements from the entry diagnostic oGTT, glucose profile and HbA1c and from subsequent glucose profiles obtained within 3 days of the ultrasound at 5 categories of GA age (20-23, 24-27 etc) were retrospectively compared between pregnancies with and without fetal macrosomia, defined as an abdominal circumference (AC) > or = 90th percentile. Maternal prepregnancy BMI was adjusted for and BMI > or = 30 kg/m2 was defined as obesity.
  
  
  RESULTS
  At entry, neither the hourly oGTT values, HbA1c, nor the entry glucose profile differed significantly between pregnancies with and without fetal macrosomia. In a total of 919 pairs of ultrasound/glucose profiles there was no significant difference in glucose levels at every GA category neither in lean nor in obese woman except for the fasting glucose of 32-35 GA. The fetal macrosomia rate in each GA category and the rate of LGA were significantly higher in obese women: e.g. 14.5 vs 28% at diagnosis, 15.7 vs 26.7% at 32-35 weeks, 15.5 vs 25.0% at birth (p < 0.05 for each comparison).
  
  
  CONCLUSIONS
  The association of maternal glucose values and fetal macrosomia was limited to the fasting glucose values between 32-35 weeks while maternal obesity appeared to be a strong risk factor for macrosomia throughout pregnancies with GDM. In obese women the high fetal macrosomia rate did not appear be normalized by therapy based on maternal euglycemia.
authors.affiliation: Department of Obstetrics, Charité, Campus Virchow Klinikum, Humboldt-University, Berlin. ute.schaefer@charite.de
authors.forename: Ute M
authors.initials: UM
authors.lastname: Schaefer-Graf
authors.forename: Rosalie
authors.initials: R
authors.lastname: Heuer
authors.forename: Omer
authors.initials: O
authors.lastname: Kilavuz
authors.forename: Angela
authors.initials: A
authors.lastname: Pandura
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Henrich
authors.forename: Klaus
authors.initials: K
authors.lastname: Vetter
mesh_terms: D000328:Adult; D001786:Blood Glucose; D016022:Case-Control Studies; D016640:Diabetes, Gestational; D005260:Female; D005320:Fetal Macrosomia / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology*; D005333:Fetus / Q000033:anatomy & histology; D005858:Germany / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D008499:Medical Records; D009765:Obesity / Q000150:complications*; D010298:Parity; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal
chemical_list: D001786:Blood Glucose