title: De novo C1q nephropathy in the renal allograft of a kidney pancreas transplant recipient: BK virus-induced nephropathy?
abstract: C1q nephropathy is a distinct entity characterized by extensive and dominant C1q mesangial deposition with associated steroid resistant proteinuria in the absence of systemic lupus erythematosus. Several morphological patterns ranging from very subtle glomerular alterations to focal/segmental glomerulosclerosis and mesangial proliferative changes have been described. Interstitial nephritis secondary to BK polyomavirus is a recently recognized complication in kidney transplant recipients. It may be associated with a tubulitis-like picture, mimicking sometimes acute tubular rejection. We report the case of a kidney pancreas transplant recipient who developed de novo C1q nephropathy, in the setting of BK polyomaviral interstitial nephritis. He presented with renal allograft dysfunction and a kidney biopsy was performed. It was interpreted as acute cellular rejection. C1q deposits were detected by immunofluorescence studies and electron microscopy. The patient did not respond clinically to appropriate anti-rejection treatment and a second renal biopsy was performed. The possibility of an interstitial nephritis secondary to BK polyomavirus mimicking rejection was suggested. Special immunohistochemical and blood/urine PCR studies for BK virus were performed, confirming the diagnosis of BK virus tubulonterstitial nephritis with a persistent, probable BK virus induced C1q nephropathy.
authors.affiliation: ARUP Laboratories, Department of Anatomical/Renal Pathology A513, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Isaac
authors.forename: Fuad S
authors.initials: FS
authors.lastname: Shihab
mesh_terms: D000328:Adult; D001739:BK Virus / Q000302:isolation & purification / Q000472:pathogenicity*; D015922:Complement C1q / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology / Q000821:virology; D007674:Kidney Diseases / Q000209:etiology / Q000276:immunology* / Q000821:virology*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology* / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000209:etiology / Q000276:immunology / Q000821:virology; D016035:Pancreas Transplantation; D027601:Polyomavirus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology; D014412:Tumor Virus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology
chemical_list: D015922:Complement C1q