Inhibition of rat glioma growth by neomycin. Preliminary report.
Tumor development is known to largely depend on angiogenesis, and nuclear translocation of angiogenic factors is one of the crucial steps in tumor angiogenesis. This preliminary study was designed to investigate the suppression of tumor growth by neomycin, an inhibitor of nuclear translocation of several angiogenic factors overexpressed in gliomas. We found that intratumoral osmotic pump delivery of 10 mM neomycin caused significant inhibition of C6 glioma tumor development (85%) in rats. The data establish neomycin as a potential inhibitor of angiogenesis-dependent tumor growth and raise the possibility for its use as therapy in pathologies in which neovascularization is involved, including neoplasia.
Cuevas
Pedro
P
Departamento de Investigación, Hospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain. pedro.cuevas@hrc.es
Carceller
Fernando
F
Diaz-González
Diana
D
Cuevas
Begoña
B
Fernández
Argentina
A
Garcia-Gómez
Ignacio
I
Dujovny
Manuel
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005910:Glioma / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D009355:Neomycin / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D009355:Neomycin