A water-soluble synthetic spicamycin derivative (San-Gly) decreases mechanical allodynia in a rodent model of neuropathic pain.
The goal of this study was to examine the effects of synthetic spicamycin derivative, SAN-Gly, on mechanical allodynia in a spared nerve injury animal model of neuropathic pain. Adult male rats underwent surgical ligation and cutting of the common peroneal and tibial nerves, which produced a mechanical allodynia within 2-4 days. One week after the surgery, SAN-Gly was administered via intravenous injection. Mechanical allodynia was measured using von-Frey hairs. Spicamycin produced a significant reduction in mechanical allodynia for up to 6 weeks. This study demonstrates that SAN-Gly may be of potential use in treating patients with neuropathic pain.
DiLorenzo
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Department of Radiology, Center for Functional Pain Neuroimaging and Therapy Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Kobierski
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L
Moore
K A
KA
Borsook
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D
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology; D010543:Peroneal Nerve / Q000503:physiopathology*; D010812:Physical Stimulation / Q000379:methods; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology; D013979:Tibial Nerve / Q000503:physiopathology*; D014867:Water
D011684:Purine Nucleosides; D014867:Water; C015502:septacidin