[Effect of furosemide on the intrarenal hemodynamics and excretory renal function depending on salt regime].
The experiments on rats showed that the dietary mineral composition influences renal circulation and saluretic function and modifies the related effects of furosemide. In particular, a high NaCl intake reduces the blood perfusion in the renal cortex and increased that in the renal medulla, thus increasing sodium excretion with urine. The use of hyposol, a table salt substituent, enhances the blood flow in the renal medulla and leads to a significant increase in the diuresis, natriuresis, and kaliuresis. Furosemide (10 mg/kg) sharply increases the medullar circulation and electrolyte excretion on the background of standard diet. However, these effects were much less pronounced on the background of hypersodium diet or hyposol administration.
Zhidomorov
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NIu
Pharmacology and Clinical Pharmacology Department, Ivanovo State Medical Academy, pr. Engel'sa 8, Ivanovo, 153462 Russia.
Shtrygol'
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SIu
D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004338:Drug Combinations; D005665:Furosemide / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply* / Q000502:physiology*; D008278:Magnesium Sulfate / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology*
D004232:Diuretics; D004338:Drug Combinations; C094275:Hyposol; D012965:Sodium Chloride; D011189:Potassium Chloride; D008278:Magnesium Sulfate; D005665:Furosemide; D012964:Sodium; D011188:Potassium