title: Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography.
abstract: A simple and sensitive high-performance liquid chromatographic method is described for the determination of colistimethate sodium in plasma and urine. The accuracy and reproducibility was within 10.1 and 11.2% with rat plasma and urine, respectively. Several commonly coadministered antibacterial agents do not interfere with the assay.
authors.affiliation: Centre for Pharmaceutical Research, University of South Australia, Adelaide, Australia.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Robert W
authors.initials: RW
authors.lastname: Milne
authors.forename: Roger L
authors.initials: RL
authors.lastname: Nation
authors.forename: John D
authors.initials: JD
authors.lastname: Turnidge
authors.forename: Kingsley
authors.initials: K
authors.lastname: Coulthard
authors.forename: Jason
authors.initials: J
authors.lastname: Valentine
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003091:Colistin / Q000031:analogs & derivatives* / Q000097:blood* / Q000652:urine*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: C004691:colistinmethanesulfonic acid; D003091:Colistin