[Laboratory and clinical study of therapeutic efficacy of medicinal films for surgical procedures].
An analysis of the experimental data showed that anesthetic medicinal films (AMFs) offer an effective medicinal form for the treatment of suppurative inflammatory disorders(SIDs) of soft tissues. The results of preclinical experiments with AMFs showed evidence of anesthetic, antimicrobial, and hemostatic effects. The therapeutic effect was established in the course of clinical investigations and confirmed by the results of cytological, histological, morphological, and bacteriological testing. The experimental data indicate that AMF application offers a promising means of SID treatment. Further development of this medicinal form must lead to an increase in the therapeutic efficacy, decrease the drug dose, and reduce the probability of side effects during the treatment of SIDs in soft tissues of various localization.
Golovanenko
A L
AL
Perm State Pharmaceutical Academy, ul. Krupskoi 46, Perm, 614070 Russia.
Oleshko
L N
LN
Iushkova
T A
TA
Odegova
T F
TF
Zarivchatskiĭ
M F
MF
Mugatarov
I N
IN
Khokhlova
R N
RN
Balakshin
N A
NA
D000328:Adult; D000464:Alginates; D000758:Anesthesia / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002266:Carboxymethylcellulose Sodium; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004337:Drug Carriers; D005260:Female; D020723:Glucuronic Acid; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D006603:Hexuronic Acids; D006801:Humans; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D051381:Rats; D013492:Suppuration / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy; D014288:Trimecaine / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
D000464:Alginates; D000779:Anesthetics, Local; D000891:Anti-Infective Agents, Local; D004337:Drug Carriers; D006490:Hemostatics; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D014288:Trimecaine; D002266:Carboxymethylcellulose Sodium; C010882:chlorhexidine gluconate; D002710:Chlorhexidine