Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin.
BACKGROUND
We encountered on seven malignant hepatocellular tumors developing in older children and adolescents.


RESULTS
These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis.


CONCLUSIONS
We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions.
Prokurat
Andrzej
A
The Children's Memorial Health Institute, Warsaw, Poland.
Kluge
Przemysław
P
Kościesza
Andrzej
A
Perek
Danuta
D
Kappeler
Andreas
A
Zimmermann
Arthur
A
D000293:Adolescent; D002295:Carcinoma, Transitional Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D002648:Child; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D018197:Hepatoblastoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D014057:Tomography, X-Ray Computed; D015534:Trans-Activators / Q000378:metabolism*; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin