title: Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine.pyrimidine interruption.
abstract: Thermal denaturation experiments have established that an oligonucleotide incorporating the artificial nucleobase S, does form a stable triplex with a double stranded DNA which exhibits a pyrimidine interruption within the oligopurine sequence.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse 91198. Gif-sur-Yvette, France.
authors.forename: D
authors.initials: D
authors.lastname: Guianvarc'h
authors.forename: R
authors.initials: R
authors.lastname: Benhida
authors.forename: J L
authors.initials: JL
authors.lastname: Fourrey
authors.forename: R
authors.initials: R
authors.lastname: Maurisse
authors.forename: J S
authors.initials: JS
authors.lastname: Sun
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000737:chemistry* / Q000378:metabolism*; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism
chemical_list: D009841:Oligonucleotides; D011687:Purines; D011743:Pyrimidines; C051802:triplex DNA; D004247:DNA