title: [Effect of new chemotherapeutic methods on the biologic tissue environment and on the immune status of patients with breast cancer].
abstract: Standard (SCT), autoplasmochemotherapy using cytostatics preincubation with autoplasma (APCT) and autoblood (autohemochemotherapy--AHCT) were compared to evaluate their effects on locally advanced breast tumors. SCT showed marked immunosuppressor effect while APCT and, particularly, AHCT--a sparing one. The use of the latter modalities involved significantly higher levels of active T-, NK- and cytotoxic CD+ 8 cells. A comparison of the latter methods also showed ABCT to yield a better subset balance between T- and B-cells and a higher level of their mitogen response.
authors.affiliation: Research Institute of Oncology, the Ministry of Health of the RF, Rostov-on-Don.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Sidorenko
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Zlatnik
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Vladimirova
authors.forename: G I
authors.initials: GI
authors.lastname: Zakora
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000276:immunology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008875:Middle Aged; D010949:Plasma / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor