Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H2O2. A remarkably simple model system for NO synthases.
Reaction of [Ru(Hedta)Cl]- with H2O2 in the presence of arginine, produces NO, in the form of an Ru(II)-(NO+) complex and citrulline which is a remarkably simple model system for the physiological NO synthase reaction.
Marmion
C J
CJ
Department of Chemistry, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland. cmarmion@rcsi.ie or kbnolan@rcsi.ie
Murphy
T
T
Nolan
K B
KB
D001120:Arginine / Q000378:metabolism*; D002956:Citrulline / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D012428:Ruthenium / Q000378:metabolism*; D017975:Ruthenium Compounds / Q000378:metabolism
D017975:Ruthenium Compounds; D002956:Citrulline; D009569:Nitric Oxide; D012428:Ruthenium; D001120:Arginine; D006861:Hydrogen Peroxide; D019001:Nitric Oxide Synthase