title: Autoimmune hepatitis in the course of chronic HAV--four year observation.
abstract: The paper presents a case of a 17-year-old girl with type 1 autoimmune hepatitis in whom biochemical, serological and histopathological markers of chronic hepatitis A were observed for the last 4 years. The diagnosis was based on elevated levels of gammaglobulins, IgG and the presence of autoantibodies (ANA, SMA). At first, the patient was treated with the pulses of corticosteroids and then, as no improvement was observed, continuous steroid therapy was involved. Relatively mild clinical course of the disease and good response to treatment with prednisone were recorded. Our observations suggest that HAV is capable of inducing autoimmune reactions and they indicate possible development of chronic hepatitis A.
authors.affiliation: 3rd Department of Paediatrics, Polish Mother's Memorial Hospital, ul. Rzgowska 281/289, 93-338 Łódź, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Woźniakowska-Gesicka
authors.forename: J
authors.initials: J
authors.lastname: Kupś
authors.forename: M
authors.initials: M
authors.lastname: Wiśniewska-Ligier
authors.forename: W
authors.initials: W
authors.lastname: Wróblewska
authors.forename: D
authors.initials: D
authors.lastname: Sułat-Syncerek
authors.forename: K
authors.initials: K
authors.lastname: al-Batool
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000906:Antibodies / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D005260:Female; D006506:Hepatitis A / Q000150:complications*; D019693:Hepatitis, Autoimmune / Q000150:complications*; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D000906:Antibodies; D000974:Antibodies, Antinuclear; D011241:Prednisone