Seven-transmembrane receptors.
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.
Pierce
Kristen L
KL
The Howard Hughes Medical Institute and the Department of Medicine, Box 3821, Duke University Medical Center, Durham, North Carolina 27710, USA.
Premont
Richard T
RT
Lefkowitz
Robert J
RJ
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D019281:Dimerization; D015536:Down-Regulation; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction; D015003:Yeasts
D011956:Receptors, Cell Surface; D020962:Heterotrimeric GTP-Binding Proteins