Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone.
A series of thiosemicarbazones and semicarbazone derivatives of (+/-)-3-menthone have been synthesized and their anti-HIV activity evaluated against HIV-1(III(B))and HIV-2 (ROD). The studies revealed that maximum protection is offered by chloro-substituted derivatives 2 and 7 against HIV-1 (III(B)) and HIV-2 (ROD).
Mishra
Vibha
V
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, India.
Pandeya
S N
SN
Pannecouque
Christophe
C
Witvrouw
Myriam
M
De Clercq
E
E
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D008610:Menthol / Q000138:chemical synthesis* / Q000494:pharmacology*; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology
D019380:Anti-HIV Agents; D012664:Semicarbazones; D013882:Thiosemicarbazones; D008610:Menthol; C019466:menthone