title: Involvement of nitric oxide in orthodontic tooth movement in rats.
abstract: Nitric oxide (NO) is an important regulatory molecule in bone formation and resorption. The purpose of this study was to examine the role of NO in orthodontic tooth movement in rats. We used specific inhibitors of NO synthases (NOS). Upper first molars of 9-week-old male Wistar rats were moved buccally for 21 days. The local administration of N(G)-nitro-L-arginine methyl ester. HCl (L-NAME), a general inhibitor of NOS activity, significantly reduced tooth movement. On the other hand, N(6)-(1-iminoethyl)-L-lysine. 2HCl (L-NIL), a selective inhibitor of the inducible isoform of NOS, had no effect. These results suggest that NO is an important biochemical mediator in the response of periodontal tissue to orthodontic force and is produced primarily through the activity of constitutive NOS.
authors.affiliation: Division of Orthodontics, Department of Life-Long Oral Health Science, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Keigo
authors.initials: K
authors.lastname: Hayashi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Igarashi
authors.forename: Kotaro
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shinoda
authors.forename: Hideo
authors.initials: H
authors.lastname: Mitani
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008437:Maxilla; D008963:Molar; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010012:Osteogenesis / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013223:Statistics as Topic; D014087:Tooth Movement Techniques
chemical_list: D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D007527:Isoenzymes; C090663:N(6)-(1-iminoethyl)lysine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D008239:Lysine; D019331:NG-Nitroarginine Methyl Ester