Evaluation of commercial Ginkgo biloba dietary supplements for the presence of colchicine by high-performance liquid chromatography.
A high-performance liquid chromatographic method with photodiode array detection was developed for the detection of the presence of colchicine in commercial ginkgo products. The method is based on the baseline separation of constituents in ginkgo samples plus reference colchicine. The minimal detectable concentration of colchicine is 1.0 ng on column in the current assay. By analysis of retention time and UV profile of suspect peaks in the sample with those of reference colchicine, none of the nine commercial ginkgo products analyzed contained colchicine.
Li
W
W
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
Fitzloff
J F
JF
Farnsworth
N R
NR
Fong
H H S
HH
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003078:Colchicine / Q000032:analysis*; D019587:Dietary Supplements / Q000032:analysis*; D020441:Ginkgo biloba / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D003078:Colchicine