[Influence of drug compatibility on extractive retes of chlorogenic acid and isochlorogenic acid in simiaoyonglan tang decoction].
OBJECTIVE
To study the influence of drug compatibility on the extractive rates of chlorogenic acid and isochlorogenic acid in Simiaoyonglan Tang (SMYAT) decoction.


METHODS
The contents of chlorogenic acid and isochlorogenic acid in SMYAT decoction, Flos Lonicerae and Flos Lonicerae in combination with other single drugs were determined by TLC-UV spectrophotometry respectively. The data from this experiment were treated statistically.


RESULTS
The contents of chlorogenic acid in other five prescriptions of different compatibilities decreased markedly in comparison with those in Flos Loniceraés decoction (P < 0.01). The content of isochlorogenic acid in SMYAT decoction as a whole was about the same as thar in Flos Loniceraés decoction, but decreased significantly in other prescriptions of different compatibilities (P < 0.01).


CONCLUSIONS
Drug compatibility is one of the main causes for changes of chlorogenic acid and isochlorogenic acid contents in SMYAT decoction.
Xi
X
X
Guiyang College of TCM, Guiyang 550002.
Liu
G
G
D029971:Angelica sinensis / Q000737:chemistry; D027922:Caprifoliaceae / Q000737:chemistry; D002726:Chlorogenic Acid / Q000031:analogs & derivatives / Q000032:analysis*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D031239:Lonicera / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D032266:Scrophularia / Q000737:chemistry
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C469310:isochlorogenic acid; D002726:Chlorogenic Acid