title: Synthesis and anticonvulsant properties of new 1-phenyl and 1-phenylamino-3-phenylpyrrolidine-2,5-dione derivatives.
abstract: A series of N-aryl and N-aminoaryl 3-phenyl pyrrolidine-2,5-diones were synthesized and tested for anticonvulsant activity in the maximum electroshock seizure (MES) and pentetrazol seizure threshold (sc Met) tests. Structures of the novel compounds were confirmed by elemental and spectral analyses.
authors.affiliation: Department of Pharmaceutical Chemistry, Collegium Medicum of the Jagiellonian University, Kraków, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Obniska
authors.forename: Alfred
authors.initials: A
authors.lastname: Zeic
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zagórska
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D011759:Pyrrolidines