Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography.
A simple and sensitive high-performance liquid chromatographic method is described for the determination of colistimethate sodium in plasma and urine. The accuracy and reproducibility was within 10.1 and 11.2% with rat plasma and urine, respectively. Several commonly coadministered antibacterial agents do not interfere with the assay.
Li
Jian
J
Centre for Pharmaceutical Research, University of South Australia, Adelaide, Australia.
Milne
Robert W
RW
Nation
Roger L
RL
Turnidge
John D
JD
Coulthard
Kingsley
K
Valentine
Jason
J
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003091:Colistin / Q000031:analogs & derivatives* / Q000097:blood* / Q000652:urine*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
C004691:colistinmethanesulfonic acid; D003091:Colistin