Naproxen ion-selective electrode and its application to pharmaceutical analysis.
An ion-selective membrane electrode was prepared based on ion-pair complex of naproxen with methyltrioctylammonium. Its basic analytical parameters such as: slope characteristics, measuring range, detection limit, response time, life time were determined. The electrode showed Nernstian response from the 10(-1) to 10(-4) mol l(-1) concentration range and 5.5-8.5 pH range, low limit of detection 5 x 10(-5) mol l(-1) and short response time--20s. Selectivity was good over a number of organic and inorganic anions. The electrode was applied for the determination of naproxen tablets in aqueous solutions by the calibration curve method and standard addition method.
Lenik
Joanna
J
Faculty of Chemistry, Maria Curie-Skłodowska University, Lublin, Poland.
Dumkiewicz
Ryszard
R
Wardak
Cecylia
C
Marczewska
Barbara
B
D017736:Ion-Selective Electrodes / Q000706:statistics & numerical data; D009288:Naproxen / Q000032:analysis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods
D009288:Naproxen