Preparation of (99m)Tc-C(60)(OH)(x) and its biodistribution studies.
The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C(60) derivative for biodistriburtion studies, the (99m)Tc-labeling of C(60)(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the (99m)Tc-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that (99m)Tc-C(60)(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h.
Qingnuan
Li
L
Shanghai Institute of Nuclear Research, the China Academy of Sciences, P.O. BOX 800-204, Shanghai 201800, China.
yan
Xiu
X
Xiaodong
Zhang
Z
Ruili
Liu
L
qieqie
Du
D
Xiaoguang
Shun
S
Shaoliang
Chen
C
Wenxin
Li
L
D000818:Animals; D005260:Female; D037741:Fullerenes / Q000737:chemistry / Q000493:pharmacokinetics*; D007553:Isotope Labeling / Q000379:methods; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013667:Technetium / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D014915:Whole-Body Counting
D037741:Fullerenes; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013667:Technetium; C069837:fullerene C60