title: Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin a, a new antitumor macrolide lactam from the sponge poecillastra species.
abstract: Poecillastrin A (1), a new polyketide-derived macrolide lactam, was isolated from a deep-water collection of the marine sponge Poecillastra species. The structure of poecillastrin A (1) was assigned using NMR data acquired at 500 MHz with an inverse-detection cryogenic probe and at 800 MHz with a room-temperature probe.
authors.affiliation: Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Rashid
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Gustafson
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Crouch
authors.forename: Amiram
authors.initials: A
authors.lastname: Groweiss
authors.forename: Lewis K
authors.initials: LK
authors.lastname: Pannell
authors.forename: Que N
authors.initials: QN
authors.lastname: Van
authors.forename: Michael R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D003080:Cold Temperature; D007769:Lactams / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007769:Lactams; D018942:Macrolides; C467924:poecillastrin A