3'-amino-2',4'-BNA: novel bridged nucleic acids having an N3'-->P5' phosphoramidate linkage.
Novel oligonucleotide analogues, containing a 3'-amino-2',4'-BNA unit, were successfully synthesized, and they showed superior duplex and triplex forming ability as well as BNA itself, along with remarkable enzymatic stability.
Obika
S
S
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Onoda
M
M
Morita
K
K
Andoh
J
J
Koizumi
M
M
Imanishi
T
T
D000577:Amides / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010756:Phosphoric Acids / Q000737:chemistry*; D010727:Phosphoric Diester Hydrolases / Q000494:pharmacology; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D012910:Snake Venoms / Q000201:enzymology
D000577:Amides; D001952:Bridged-Ring Compounds; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D010756:Phosphoric Acids; D012910:Snake Venoms; D012313:RNA; D004247:DNA; C011067:phosphoramidic acid; D010727:Phosphoric Diester Hydrolases