title: Antioxidative components of Psoralea corylifolia (Leguminosae).
abstract: A meroterpene and four flavonoids were isolated from the seeds of Psoralea corylifolia as antioxidative components. Their structures were elucidated by spectral data and identified as bakuchiol (1), bavachinin (2), bavachin (3), isobavachin (4) and isobavachalcone (5). In particular, meroterpene 1 and flavonoids 4 and 5 showed broad antioxidative activities in rat liver microsomes and mitochondria. They inhibited NADPH-, ascorbate-, t-BuOOH- and CCl(4)-induced lipid peroxidation in microsomes. They also prevented NADH-dependent and ascorbate-induced mitochondrial lipid peroxidation. Bakuchiol (1) was the most potent antioxidant in microsomes and the inhibition of oxygen consumption induced by lipid peroxidation was time-dependent. Furthermore, bakuchiol (1) protected human red blood cells against oxidative haemolysis. These phenolic compounds in P. corylifolia were shown to be effective in protecting biological membranes against various oxidative stresses.
authors.affiliation: Faculty of Engineering, Fukuyama University, Gakuen-cho, Japan. haragu@bt.fubt.fuyukama-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Haraguchi
authors.forename: Junji
authors.initials: J
authors.lastname: Inoue
authors.forename: Yukiyoshi
authors.initials: Y
authors.lastname: Tamura
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizutani
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047188:Chalcones; D004912:Erythrocytes / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D015394:Molecular Structure; D010101:Oxygen Consumption / Q000187:drug effects; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D029907:Psoralea; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D047309:Flavones
chemical_list: D000975:Antioxidants; D002599:Chalcone; D047188:Chalcones; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; C459212:bavachin; C468754:isobavachalcone; C468753:isobavachin; C012765:bakuchiol; C468752:bavachinin; D047309:Flavones