[Chronic lupus erythematosus presenting as acneiform lesions].
BACKGROUND
Cutaneous manifestations of lupus erythematosus are numerous but usually permit easy diagnosis. However, there are atypical lesions that can mimic benign dermatologic disorders. We report on a patient with lesions of acne leading to the diagnosis of chronic lupus erythematosus, and who subsequently developed systemic lupus erythematosus.


METHODS
A 30-year-old woman presented with inflammatory lesions and comedos on the face. The eruption started after her last pregnancy and was refractory to local and general treatment. She also complained of arthralgia, Raynaud's phenomenon and diffuse alopecia. Cutaneous biopsy was characteristic of chronic lupus erythematosus. Immunofluorescence microscopy of lesional skin showed a lupus band deposit. Antinuclear antibodies were highly positive. The patient was successfully treated with chloroquine. Three years later, the patient presented with photodistributed eruption. Antinuclear antibodies were still positive and in addition anticardiolipin antibodies were found. Final diagnosis was systemic lupus erythematosus.


CONCLUSIONS
Acneiform lesions are rarely reported in lupus erythematosus. Only three similar cases were reported in literature. Atypical and treatment-resistant eruptions should attract attention. Furthermore, the occurrence of systemic lupus in chronic lupus erythematosus is not an unfrequent phenomenon and the oestrogen-dependance of chronic lupus lesions may predict this association.
Deruelle-Khazaal
R
R
Clinique dermatologique, Hôpital Claude Huriez, CHRU, 59037 Lille Cedex, France. pierthomas@chru-lille.fr
Ségard
M
M
Cottencin-Charrière
A C
AC
Carotte-Lefebvre
I
I
Thomas
P
P
D017486:Acneiform Eruptions / Q000209:etiology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001706:Biopsy; D002738:Chloroquine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000175:diagnosis*
D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D018501:Antirheumatic Agents; D002738:Chloroquine