Proposed modifications to metabolic model for glycogen-accumulating organisms under anaerobic conditions.
Filipe et al. (2001) proposed an anaerobic metabolic model for glycogen-accumulating organisms (GAO) in which the succinate-propionate pathway was used to describe the production of propionyl-CoA. However, propionyl-CoA is only an intermediate product in the above pathway. Stopping at propionyl-CoA instead of propionate (the end product of the pathway) results in the consumption of one ATP from succinate to succinyl-CoA, which was not accounted for in the model of Filipe et al. (2001). This resulted in significant errors in the stoichiometric coefficients in the final metabolic model. A modified model is presented in this communication and is shown to fit the experimental data significantly better than the original model.
Zeng
Raymond
R
Advanced Wastewater Management Centre, University of Queensland, Brisbane QLD 4072, Australia.
Yuan
Zhiguo
Z
Van Loosdrecht
Mark C M
MC
Keller
Jürg
J
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000214:Acyl Coenzyme A / Q000378:metabolism; D000693:Anaerobiosis; D001421:Bacteria, Anaerobic / Q000378:metabolism*; D003198:Computer Simulation; D006003:Glycogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006885:Hydroxybutyrates / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical; D011091:Polyesters / Q000378:metabolism; D011422:Propionates / Q000378:metabolism; D011786:Quality Control; D012680:Sensitivity and Specificity; D013386:Succinates / Q000378:metabolism
D000214:Acyl Coenzyme A; D006885:Hydroxybutyrates; D011091:Polyesters; D011422:Propionates; D013386:Succinates; C009061:propionyl-coenzyme A; D000105:Acetyl Coenzyme A; D006003:Glycogen