title: Phosphorylation of adenosine with trimetaphosphate under simulated prebiotic conditions.
abstract: The phosphorylation of adenosine with trimetaphosphate in solution, in solid phase and using wet-dry cycles was carried out and it was found that wet-dry cycles were the most efficient. The catalytic effects of some metal ions on the phosphorylation were also studied and it was discovered that Ni(II) is the most effective. The combination of wet-dry cycles (4 cycles) and catalysis by Ni(II) led to an unprecedented high conversion of adenosine to phosphorylated products (30%) near neutral pH. The main phosphorylated products were 2',3'-cyclic AMP (10.4%) and 5'-ATP (13.0%).
authors.affiliation: Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, PR China.
authors.forename: Changmei
authors.initials: C
authors.lastname: Cheng
authors.forename: Chang
authors.initials: C
authors.lastname: Fan
authors.forename: Rong
authors.initials: R
authors.lastname: Wan
authors.forename: Chunyuan
authors.initials: C
authors.lastname: Tong
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Miao
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000241:Adenosine / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D010766:Phosphorylation
chemical_list: D010710:Phosphates; D000241:Adenosine