T-cell activation: a multidimensional signaling network.
Naïve T cell activation requires the interactions of antigen receptors, adhesion molecules and co-stimulatory molecules. Antigen receptors and adhesion molecules are involved in spatio-temporal movement to form a stable immunological synapse. This stable junction interrupts T cell migration, and provides a platform for temporally regulated co-stimulatory receptor signaling spanning a period of days.
Tseng
Su-Yi
SY
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Dustin
Michael L
ML
D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013569:Synapses; D013601:T-Lymphocytes / Q000502:physiology*; D013997:Time Factors