[Effect of curcumin on the proliferation of murine CFU-GM and WEHI-3B cells].
OBJECTIVE
To evaluate the effect of curcumin on the proliferation of hematopoietic progenitor cells or leukemic stem cells.


METHODS
Mouse bone marrow cells (colony forming unit-granulocyte and macrophage, CFU-GM) and WEHI-3B cells were observed using the colony assays.


RESULTS
The curcumin significantly inhibited the proliferation of both CFU-GM and WEHI-3B cells in a dose-dependent manner ranging from 10(-8) to 10(-4) mol.L-1; their IC50S were 1.036 x 10(-5) mol.L-1 and 1.220 x 10(-6) mol.L-1 of curcumin respectively.


CONCLUSIONS
The proliferation of murine CFU-GM and WEHI-3B cells can be suppressed by curcumin. The inhibitory effect of curcumin on the proliferation of WEHI-3B cells is stronger than that of CFU-GM.
Jiang
D Z
DZ
Research Laboratory of Blood Physiology, Hunan Medical University, Changsha 410078.
Xie
Q Y
QY
Wang
Q R
QR
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003474:Curcumin / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D015479:Leukemia, Myelomonocytic, Acute / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004247:DNA; D003474:Curcumin