[Food phytosterol ester efficiency on the plasma lipid reduction in moderate hypercholesterolemic subjects].
OBJECTIVE
This study aimed at relating the pattern of response to dietary plant sterol ester (PSE) treatment of plasma lipids concentrations and apo E polymorphisms.


METHODS
Patients (20-60y old: 50 women; 10 men) with primary moderate hypercholesterolemia were fed margarine (20g/d), received no treatment (placebo), and were fed PSE (2.8g/d = 1.68 phytosterols), during 3 periods of 4 weeks each, in a crossover, double-blind study. DNA was extracted from white blood cells for the apo E polymorphisms.


RESULTS
PSE treatment significantly lowered TC and LDL-C 10% and 12%, respectively, in relation to the baseline, and 6% and 8% in relation to the placebo phase, but HDL-C and TG levels were not modified. In regard to the apo E genotyping, no significant difference occurred between apo E 3/3 and apo E (3/4).


CONCLUSIONS
Dietary plant sterol ester (PSE) treatment reduced cholesterolemia, and the reduction of LDL-C in absolute values was more pronounced when the initial LDL - C concentration were elevated.
Lottenberg
Ana M P
AM
Laboratorio de Lipides do Hospital das Clinicas da FMUSP, Sao Paulo, Brazil.
Nunes
Valéria S
VS
Nakandakare
Edna R
ER
Neves
Mônica
M
Bernik
Márcia
M
Santos
José E
JE
Quintao
Eder C R
EC
D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004311:Double-Blind Method; D004952:Esters; D005260:Female; D005838:Genotype; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008383:Margarine; D008875:Middle Aged; D010840:Phytosterols / Q000494:pharmacology*; D008517:Phytotherapy; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004952:Esters; D010840:Phytosterols; D014280:Triglycerides; D008383:Margarine; D002784:Cholesterol