title: Fixed-effect versus random-effect models for evaluating therapeutic preferences.
abstract: A preference trial is a special form of cross-over trial where clinical conditions determine when patients change treatment, in a prescribed order. This leads to binary responses with variable lengths. In cross-over trials with normal responses, patient effect may be treated as either fixed or random. However, with binary responses, random- and fixed-effect assumptions may lead to very different conclusions, so that one is no longer an alternative to the other.
authors.affiliation: Department of Statistics, Seoul National University, Kwanakgu, Sinrimdong, Seoul, Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
mesh_terms: D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods*; D018592:Cross-Over Studies; D006801:Humans; D015233:Models, Statistical
chemical_list: D001993:Bronchodilator Agents