Chlamydial antigens colocalize within IncA-laden fibers extending from the inclusion membrane into the host cytosol.
Chlamydial IncA localizes to the inclusion membrane and to vesicular fibers extending away from the inclusion. Chlamydial outer membrane components, in the absence of developmental forms, are found within these fibers. This colocalization may explain how chlamydial developmental form antigens are localized outside of the inclusion within infected cells.
Brown
W J
WJ
Department of Microbiology, Oregon State University, Corvallis, Oregon 97331, USA.
Skeiky
Y A W
YA
Probst
P
P
Rockey
D D
DD
D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D002455:Cell Division; D002689:Chlamydia / Q000276:immunology* / Q000378:metabolism / Q000472:pathogenicity; D002690:Chlamydia Infections / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D002691:Chlamydophila psittaci / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D006367:HeLa Cells; D006801:Humans; D002479:Inclusion Bodies / Q000382:microbiology; D008856:Microscopy, Fluorescence; D010750:Phosphoproteins / Q000378:metabolism*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C094163:IncA protein, bacteria; D010750:Phosphoproteins