Causes of insulin resistance in childhood.
The increasing incidence of type 2 diabetes worldwide is causing concern. Genetic and environmental influences have been put forward to explain the origins of this disease, but perhaps the most convincing contributory factor is high body weight. The authors review the literature on the subject to identify some of the predisposing factors influencing healthcare practitioners' concerns about the issue.
Jeffery
Alison
A
Early Bird Research Centre, Derriford Hospital, Plymouth. alison.jeffery@phnt.swest.nhs.uk
Voss
Linda
L
Metcalf
Brad
B
Wilkin
Terence
T
D001724:Birth Weight; D001835:Body Weight; D015984:Causality; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D014943:Global Health; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000150:complications; D015995:Prevalence; D012016:Reference Values; D006113:United Kingdom / Q000453:epidemiology