[Protective effect of perindopril on dysfunction of endothelium-dependent relaxation in diabetic rats].
To investigate the effect of Perindopril, an angiotensin converting enzyme(ACE) inhibitor, on dysfunction of ECs-dependent relaxation in diabetic rats induced by streptozotocin(STZ) at different times, acetylcholine(Ach)-induced ECs-dependent relaxation of rat aortic rings was tested, and the concentrations of plasma glucose and AngII were measured. The results showed that: 1. Four weeks later after injecting STZ, the function of ECs-dependent relaxation was not injured in diabetic control group(DC), but the concentrations of plasma glucose and AngII were increased significantly compared with normal control group(NC). The Ach-induced relaxation was declined obviously compared with NC at 8 or 16 weeks after injecting STZ. 2. treatment with Perindopril significantly protected the function of ECs-dependent relaxation, the Ach-induced relaxation was obviously increased compared with DC. The concentration of plasma glucose was not changed, but the plasma AngII was reduced compared with DC.


CONCLUSIONS
Perindopril could protect the function of ECs-dependent relaxation in diabetic rats.
Liu
S K
SK
Department of Pharmacology, Hunan Medical University, Changsha 410078.
Chen
X
X
You
J L
JL
Zhou
M
M
D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D020913:Perindopril / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014664:Vasodilation / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D020913:Perindopril