title: Nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis in a patient of Waldenström's macroglobulinemia.
abstract: A 72-year-old man was diagnosed as having nephritic syndrome complicated by Waldenström's macroglobulinemia (WM). A monoclonal IgM lambda protein and decreased serum complements were observed. The renal biopsy disclosed the capillary occluded by thrombi which was stained with IgG, IgA, IgM, C4, lambda light chain and slight kappa light chain in a granular pattern. Electron dense deposits were noted in the subendothelial spaces. An unusual case of WM who developed nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis is described.
authors.affiliation: Department of Internal Medicine, Saga Medical School, Nabeshima 5-1-1, Saga 849-8501, Japan.
authors.forename: Souichiro
authors.initials: S
authors.lastname: Haraguchi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tomiyoshi
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Aoki
authors.forename: Takanobu
authors.initials: T
authors.lastname: Sakemi
mesh_terms: D000368:Aged; D003181:Complement C4 / Q000172:deficiency; D003165:Complement System Proteins / Q000172:deficiency*; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D003181:Complement C4; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D003165:Complement System Proteins