title: Age-related changes in plasma orexin-A concentrations.
abstract: To study the effect of aging on orexin-A, we measured plasma orexin-A concentrations in 82 healthy volunteers (55 men and 27 women) over a wide range of ages (mean 50.2 +/- 13.9 years, ranging from 23 to 79 years). Correlation analyses revealed that plasma orexin-A concentrations correlated with age (r = 0.50, P < 0.01). When comparing three age groups, it appeared that the concentrations in the group of more than 60 years were significantly higher than those in the group of less than 39 years in both genders (P < 0.05). These findings suggest that orexin-A could be involved in aging in a healthy population.
authors.affiliation: Department of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsumura
authors.forename: Mika
authors.initials: M
authors.lastname: Nakayama
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nomura
authors.forename: Asuka
authors.initials: A
authors.lastname: Naito
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kamahara
authors.forename: Kennosuke
authors.initials: K
authors.lastname: Kadono
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inoue
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Homma
authors.forename: Kiyohisa
authors.initials: K
authors.lastname: Sekizawa
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D000068797:Orexins
chemical_list: D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D009479:Neuropeptides; D000068797:Orexins