Mycosis fungoides presenting as Ofuji's papuloerythroderma.
We report three patients presented with clinical features of Ofuji's papuloerythroderma (pruritic erythematous papules and extensive erythema sparing all skin folds), however, showing histopathological findings of mycosis fungoides (Pautrier's microabscess, haloed lymphocytes, disproportionate epidermotropism, and wiry collagen bundles). One case was associated with plaque stage of mycosis fungoides and follicular mucinosis. T-cell receptor (TCR) gene rearrangement analysis in the lesional skin tissue demonstrated rearrangement of the gamma chain in all cases. HTLV-1 serology was negative for two patients who conducted HTLV-1 test. We think that Ofuji's papuloerythroderma might be a variant of early mycosis fungoides rather than secondary skin manifestations to certain cutaneous inflammatory diseases.
Hur
J
J
Department of Dermatology, Kosin Medical Center, Pusan, South Korea.
Seong
J Y
JY
Choi
T S
TS
Jang
J G
JG
Jang
M S
MS
Suh
K S
KS
Kim
S T
ST
D000368:Aged; D001707:Biopsy, Needle; D003873:Dermatitis, Exfoliative / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D011701:PUVA Therapy; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome