Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants.
We studied the association between plasma total homocysteine concentrations and the occurrence of stroke in newborn infants (n = 24). Newborn infants with stroke had significantly higher mean total homocysteine concentrations compared with 94 healthy newborn infants (9.3 vs 7.4 micromol/L). The odds ratio for neonatal stroke was 3.95 (95" CI 1.53-10.16) at the 80" cutoff level.
Hogeveen
Marije
M
Department of Pediatrics, University of Nijmegen Medical Center, Nijmegen, The Netherlands.
Blom
Henk J
HJ
Van Amerongen
Marjolein
M
Boogmans
Bas
B
Van Beynum
Ingrid M
IM
Van De Bor
Margot
M
D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D007231:Infant, Newborn; D016015:Logistic Models; D009426:Netherlands / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000209:etiology*