A stem cell molecular signature.
Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.
Ivanova
Natalia B
NB
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Dimos
John T
JT
Schaniel
Christoph
C
Hackney
Jason A
JA
Moore
Kateri A
KA
Lemischka
Ihor R
IR
D000328:Adult; D000818:Animals; D002450:Cell Communication; D002453:Cell Cycle; D002454:Cell Differentiation; D002460:Cell Line; D019070:Cell Lineage; D002469:Cell Separation; D002478:Cells, Cultured; D019295:Computational Biology; D004622:Embryo, Mammalian / Q000166:cytology; D020224:Expressed Sequence Tags; D015870:Gene Expression; D020869:Gene Expression Profiling; D005801:Genes, Homeobox; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D051379:Mice; D009474:Neurons / Q000166:cytology; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology*; D039901:Totipotent Stem Cells / Q000502:physiology*; D014158:Transcription, Genetic