Molecular mechanisms of nickel carcinogenesis.
A brief review of the molecular mechanisms of nickel carcinogenesis is presented. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of nickel-induced gene silencing by DNA hypermethylation in mammalian cells and by its ability to inhibit histone acetylation. Model systems designed to study the molecular mechanism of gene silencing are discussed.
Costa
Max
M
Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA.
D000107:Acetylation; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002843:Chromatin / Q000187:drug effects; D020868:Gene Silencing / Q000187:drug effects; D006657:Histones / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009532:Nickel / Q000633:toxicity*
D002273:Carcinogens; D002843:Chromatin; D006657:Histones; D009532:Nickel