[In vivo degradation and tissue compatibility of polyphosphazene blend films].
The degradation performance and tissue compatibility of polyphosphazene/polyester or polyanhydride (PGP/PLGA or PGP/PSTP) blend films were investigated in mice. The results showed that the blend degradation rate could be regulated by adjusting PLGA or PSTP content in the blends. For example, the weight loss of PGP/PLGA (70:30 by wt) film was 68.4% after 55 days, whereas that of PGP/PSTP (70:30 by wt) was 88.5% only after 12 days. Also the mechanisms for in vivo degradation of blends of PGP/PLGA and PGP/PSTP were hydrolysed enzymatically and non-enzymatically, respectively. The tissue compatibility of PGP/PLGA was better than that of PGP/PSTP, and an increase of the percentage of PGP in PGP/PSTP blends would help improve the tissue compatibility. These findings suggested that polyphosphazene blends be potential materials applied in medical field.
Qiu
Liyan
L
College of Pharmaceutical Science, Zhejiang University, Hangzhou 310006.
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D051379:Mice; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D001672:Biocompatible Materials; D009943:Organophosphorus Compounds; D011091:Polyesters; D011108:Polymers; C108974:poly(phosphazene)