Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria.
Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria.
Stoelcker
Benjamin
B
Institute of Pathology/Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany.
Hehlgans
Thomas
T
Weigl
Karin
K
Bluethmann
Horst
H
Grau
Georges E
GE
Männel
Daniela N
DN
D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D001792:Blood Platelets / Q000473:pathology; D001808:Blood Vessels / Q000276:immunology*; D016026:Bone Marrow Transplantation; D002560:Cerebrovascular Circulation / Q000276:immunology; D002678:Chimera; D004730:Endothelium, Vascular / Q000276:immunology; D016779:Malaria, Cerebral / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018512:Parasitemia / Q000209:etiology / Q000276:immunology; D010962:Plasmodium berghei; D018124:Receptors, Tumor Necrosis Factor / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D047889:Receptors, Tumor Necrosis Factor, Type II
D015703:Antigens, CD; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II