[Relationship between the quantities of virus and the models of serologic markers in patients infected with HBV].
OBJECTIVE
To explore the relationship between the quantities of HBV and the models of serologic markers.


METHODS
Real-time fluorescent quantitative PCR was used to measure the HBV DNA and ELISA was used to detect the antigen/antibody of HBV.


RESULTS
The patients whose HBV copies were more than 10(3)/ml accounted for 87.3%, whose copies were more than 10(7)/ml accounted for 66.7% among the HBsAg and HBeAg -positive patients. The patients whose HBV copies were less than 10(3)/ml accounted for 74.5%, whose HBV copies were more than 10(7)/ml accounted for 8.3% among the HBeAg-negative patients. The HBV copies of HBeAg-positive patients were significantly more than HBeAg-negative patients (P<0.01). The HBV copies of anti-HBe-negative patients were significantly more than anti-HBe-positive patients (P<0.01). The HBV DNA was detected in some HBsAg-negative patients. One patient's HBV copies were as high as 1.59 10(9)/ml.


CONCLUSIONS
The HBV copies of HBeAg-positive patients are significantly more than HBeAg-negative patients, The HBV copies of anti-HBe-negative patients are significantly more than the anti-HBe-positive patients. However, some HBeAg-positive patient's HBV copies are very low, and some HBeAg-negative patient's HBV copies are very high. HBV DNA even could be detected in some HBsAg-negative patients. It is difficult to judge accurately the quantities of HBV and infectivity according to the serologic markers for a specific patient.
Yang
Xu
X
Liver Disease Research Center, Xiangya Second Affiliated Hospital, Central South University, Changsha 410011, China.
Luo
Hong Yu
HY
Zhang
Yong Hong
YH
Qian
Huan Ying
HY
Zeng
Xiao Bo
XB
Huang
Li
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens