title: On the Molecular Mechanism of the Tumor Suppressor Function of cDNA Clone p14-6.
abstract: Interactions between the RNA transcript of the tumor suppressor cDNA clone, p14-6 (the 3'untranslated region of the nuclear factor for human interleukin-6; NF-IL6 3'UTR), and the reversion-related proteins BNF, were investigated. It was found that: (1) the recognition site of the RNA for BNFs was a 24-nucleotide segment located within the 3'-proximal U-rich sequence; (2) the BNFs were a group of proteins which may interact with each other before interacting with a site on the RNA as a protein complex; (3) possibly only one protein in the complex, namelyR62, directly bound to the RNA site.
authors.affiliation: Shanghai Institute of Biochemistry, Academia Sinica, Shanghai 200031, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Ding-Gan
authors.initials: DG
authors.lastname: Liu
authors.forename: Zai-Ping
authors.initials: ZP
authors.lastname: Li