title: Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder.
abstract: Studies investigating carbamazepine (CBZ) in the treatment of cocaine dependence have been inconsistent. In this study, cocaine-dependent individuals with (n = 57) and without (n = 82) affective disorder were compared in a 12-week, double-blind, placebo-controlled trial. Urine drug screens (UDS) and self-report of drug use were collected weekly. Affective symptoms were measured monthly. Subjects receiving CBZ attended more medication sessions (p = .03). The CBZ-treated affective group had a trend toward fewer cocaine-positive UDS (p = .08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA. bradyk@musc.edu
authors.forename: Kathleen T
authors.initials: KT
authors.lastname: Brady
authors.forename: Susan C
authors.initials: SC
authors.lastname: Sonne
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Malcolm
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Randall
authors.forename: Bonnie S
authors.initials: BS
authors.lastname: Dansky
authors.forename: Kit
authors.initials: K
authors.lastname: Simpson
authors.forename: James S
authors.initials: JS
authors.lastname: Roberts
authors.forename: Michael
authors.initials: M
authors.lastname: Brondino
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D016019:Survival Analysis
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine