title: Effect of tonsillectomy on serum concentrations of interleukins and TNF-alpha in patients with chronic tonsillitis.
abstract: We investigated serum interleukin (IL)-1beta, IL-4, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha levels in 17 children aged 5-12 years (mean 7) with chronic tonsillitis before and after tonsillectomy. Cytokine concentrations were measured by enzyme-linked immunosorbent assay. IL-1beta and IL-6 levels were significantly higher than the control levels (p < 0.05) in preoperative serum samples. Other cytokine levels were within normal limits. After tonsillectomy, IL-1beta and IL-6 levels were significantly reduced (p < 0.05). It is suggested that IL-1beta and IL-6 may be mediators which have a role in chronic tonsillitis disease and that tonsillectomy has a significant effect on preoperative IL-1beta and IL-6 serum levels.
authors.affiliation: Department of Otolaryngology, Mersin University, Faculty of Medicine, Mersin, Turkey. muunal@hotmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Unal
authors.forename: Candan
authors.initials: C
authors.lastname: Oztürk
authors.forename: Kemal
authors.initials: K
authors.lastname: Görür
mesh_terms: D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D018709:Statistics, Nonparametric; D014068:Tonsillectomy; D014069:Tonsillitis / Q000097:blood* / Q000601:surgery*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha