title: Open lung biopsy in bone marrow transplant recipients has a poor diagnostic yield for a specific diagnosis.
abstract: The diagnostic yield of open lung biopsy (OLB) in bone marrow transplantation (BMT) recipients having pulmonary infiltrates has not been evaluated recently. Therefore, we reviewed our 2-year experience (1998-99) with such patients at The University of Texas M. D. Anderson Cancer Center. We found 12 BMT recipients who underwent OLB analysis for the evaluation of pulmonary infiltrates. A treatable infectious etiology leading to the initiation or modification of antimicrobial agent administration was found in only two patients having bilateral nodular disease and one having bilateral parenchymal infiltrates. We conclude that OLB in BMT patients having diffuse pulmonary infiltrates has a low diagnostic yield for treatable infectious etiologies.
authors.affiliation: Department of Infectious Diseases, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Z H A
authors.initials: ZH
authors.lastname: Shaikh
authors.forename: H A
authors.initials: HA
authors.lastname: Torres
authors.forename: G L
authors.initials: GL
authors.lastname: Walsh
authors.forename: R E
authors.initials: RE
authors.lastname: Champlin
authors.forename: D P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001706:Biopsy / Q000379:methods*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003141:Communicable Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology* / Q000601:surgery*; D008171:Lung Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008875:Middle Aged
chemical_list: D000890:Anti-Infective Agents