title: MR tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regions.
abstract: The purpose of this study was to use MR myocardial tagging to assess regional cardiac function after myocardial infarction (MI) in mice. Eight mice were imaged before and 1 day after MI. MRI included cine imaging, myocardial tagging, and contrast-enhanced imaging. Regional percent circumferential shortening (%CS) was measured from the tagged images, and the region of hyperenhancement on the contrast-enhanced images was used to determine the infarcted, adjacent, and remote zones. Ejection fraction (EF) fell from 59% +/- 6% at baseline to 32% +/- 6% after MI (P < 0.01). At baseline, %CS was 14.5% +/- 3.4%. After MI, %CS was 0.7% +/- 4.4% in the infarcted zone, 7.4% +/- 4.4% in the adjacent zone, and 11.8% +/- 4.2% in the remote zone. %CS was statistically different for all comparisons between the infarcted, adjacent, remote, and baseline groups (P < 0.01). MR tagging can detect regional differences in myocardial function post-MI in mice.
authors.affiliation: Department of Radiology, University of Virginia, Charlottesville 22908, USA.
authors.forename: Frederick H
authors.initials: FH
authors.lastname: Epstein
authors.forename: Zequan
authors.initials: Z
authors.lastname: Yang
authors.forename: Wesley D
authors.initials: WD
authors.lastname: Gilson
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Berr
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Kramer
authors.forename: Brent A
authors.initials: BA
authors.lastname: French
mesh_terms: D000818:Animals; D003287:Contrast Media; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine; D051379:Mice; D008810:Mice, Inbred C57BL; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology; D013318:Stroke Volume
chemical_list: D003287:Contrast Media