title: Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H2O2. A remarkably simple model system for NO synthases.
abstract: Reaction of [Ru(Hedta)Cl]- with H2O2 in the presence of arginine, produces NO, in the form of an Ru(II)-(NO+) complex and citrulline which is a remarkably simple model system for the physiological NO synthase reaction.
authors.affiliation: Department of Chemistry, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland. cmarmion@rcsi.ie or kbnolan@rcsi.ie
authors.forename: C J
authors.initials: CJ
authors.lastname: Marmion
authors.forename: T
authors.initials: T
authors.lastname: Murphy
authors.forename: K B
authors.initials: KB
authors.lastname: Nolan
mesh_terms: D001120:Arginine / Q000378:metabolism*; D002956:Citrulline / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D012428:Ruthenium / Q000378:metabolism*; D017975:Ruthenium Compounds / Q000378:metabolism
chemical_list: D017975:Ruthenium Compounds; D002956:Citrulline; D009569:Nitric Oxide; D012428:Ruthenium; D001120:Arginine; D006861:Hydrogen Peroxide; D019001:Nitric Oxide Synthase