Adiponectin is not altered with exercise training despite enhanced insulin action.
Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exercise training. An insulin sensitivity index (S(I)) and fasting levels of glucose, insulin, and adiponectin were assessed before and after 6 mo of exercise training (4 days/wk for approximately 45 min at 65-80% peak O(2) consumption) with no loss of body mass (PRE, 91.9 +/- 3.8 kg vs. POST, 91.6 +/- 3.9 kg) or fat mass (PRE, 26.5 +/- 1.8 kg vs. POST, 26.7 +/- 2.2 kg). Insulin action significantly (P < 0.05) improved with exercise training (S(I) +98%); however, plasma adiponectin concentration did not change (PRE, 6.3 +/- 1.5 microg/ml vs. POST, 6.6 +/- 1.8 microg/ml). In contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adiponectin (+281%), which was accompanied by enhanced insulin action (S(I), +432%). These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity.
Hulver
Matthew W
MW
Department of Physiology, East Carolina University, Greenville North Carolina 27858, USA. hulverm@mail.ecu.edu
Zheng
Donghai
D
Tanner
Charles J
CJ
Houmard
Joseph A
JA
Kraus
William E
WE
Slentz
Cris A
CA
Sinha
Madhur K
MK
Pories
Walter J
WJ
MacDonald
Kenneth G
KG
Dohm
G Lynis
GL
D052242:Adiponectin; D000328:Adult; D015992:Body Mass Index; D015444:Exercise / Q000502:physiology*; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007328:Insulin / Q000097:blood*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000601:surgery; D011506:Proteins / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology*
D052242:Adiponectin; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins