title: The mannose receptor family.
abstract: The mannose receptor family comprises four glycoproteins each of which is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II (FNII) domain and eight to ten C-type lectin-like domains (CTLDs). Characteristically, these proteins are able to recycle between the plasma membrane and the endosomal apparatus due to discrete motifs present within their cytoplasmic domains. This review discusses the structure and function of these four proteins-the mannose receptor (MR), the M-type receptor for secretory phospholipases A(2) (PLA(2)R), DEC-205/gp200-MR6 and Endo180/uPARAP. Despite their overall structural similarity, these four receptors have evolved to use different domains to interact with discrete ligands. In addition, they differ in their ability to mediate endocytic and phagocytic events and in their intracellular destinations. Together, they represent a unique group of multidomain, multifunctional receptors.
authors.affiliation: The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building Chester Beatty Laboratories, 237 Fulham Road, SW3 6JB, London, UK. l.east@icr.ac.uk
authors.forename: Lucy
authors.initials: L
authors.lastname: East
authors.forename: Clare M
authors.initials: CM
authors.lastname: Isacke
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D001665:Binding Sites; D003545:Cysteine / Q000737:chemistry; D004705:Endocytosis; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000502:physiology; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000378:metabolism; D037181:Lectins, C-Type; D008024:Ligands; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*; D015778:Minor Histocompatibility Antigens; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010587:Phagocytosis; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D011975:Receptors, Mitogen / Q000737:chemistry / Q000502:physiology*; D054507:Receptors, Phospholipase A2; D012276:Ricin / Q000737:chemistry; D016415:Sequence Alignment
chemical_list: D015703:Antigens, CD; C093569:DEC-205 receptor; C408294:Endo180; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D037102:Lectins; D037181:Lectins, C-Type; D008024:Ligands; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008562:Membrane Glycoproteins; D015778:Minor Histocompatibility Antigens; C516360:PLA2R1 protein, human; D011956:Receptors, Cell Surface; D011975:Receptors, Mitogen; D054507:Receptors, Phospholipase A2; D012276:Ricin; D003545:Cysteine