title: Selection of a suitable mobile phase for the speciation of four arsenic compounds in drinking water samples using ion-exchange chromatography coupled to inductively coupled plasma mass spectrometry.
abstract: The performance of two mobile phase buffers, phosphate and TRIS, were compared for the speciation of four arsenic species: arsenate (As(V)), arsenite (As(III)), mono methylarsonic acid (MMA), and dimethyl arsinic acid (DMA) in drinking water, using ion-exchange chromatography inductivelycoupled plasma mass spectrometry (IEC-ICP-MS). The mobile phase containing TRIS acetate buffer ("TRIS") demonstrated superior perfomance in baseline separation of all four arsenic species and the internal standard. It is also applicable to high-throughput sample analysis as it minimized the frequency required to clean the sampling interface due to salt build-up when compared to the phosphate mobile phase. The method was evaluated for its precision, accuracy, linearity and detection limits. The method was successfully applied for the analysis of drinking water samples.
authors.affiliation: Research Triangle Institute, Analytical and Chemical Sciences, RTP, NC 27709-2194, USA. lmilstein@rti.org
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Milstein
authors.forename: Amal
authors.initials: A
authors.lastname: Essader
authors.forename: Edo D
authors.initials: ED
authors.lastname: Pellizzari
authors.forename: Reshan A
authors.initials: RA
authors.lastname: Fernando
authors.forename: Olujide
authors.initials: O
authors.lastname: Akinbo
mesh_terms: D001152:Arsenicals / Q000032:analysis* / Q000737:chemistry*; D002852:Chromatography, Ion Exchange; D004784:Environmental Monitoring / Q000379:methods*; D013058:Mass Spectrometry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013439:Sulfhydryl Reagents / Q000032:analysis* / Q000737:chemistry*; D014873:Water Pollutants / Q000032:analysis*; D014881:Water Supply
chemical_list: D001152:Arsenicals; D013439:Sulfhydryl Reagents; D014873:Water Pollutants