[Effects of yi qi tong mai oral liquid on acute myocardial ischemia in dogs].
The objective of this study was to assess the prophylactic and therapeutic effects of Yi Qi Tong Mai Oral Liquid (YQTMOL) on acute myocardial ischemia. The models of ischemia were made, in which the anterior coronary arteries of anesthetized dogs were ligated. Four groups of dogs were examined and compared. We determined the extent of their myocardial ischemia and infarction by means of epicardial mapping and N-BT staining. The results showed that in the treatment groups, the increase of sigma-ST was inhibited 30-180 minutes after the oral administration of YQTMOL(compared with control group, P < 0.01), and the sigma-ST was decreased (P < 0.05). Furthermore, in the group dosed with YQTMOL (10 g/kg), the ratios of "area of infarction/heart weight" and "area of infarction/ventricle weight" both decreased (compared with control group, P < 0.05). These findings indicated that YQTMOL reduced the area of myocardial ischemia and the degree of myocardial infarction in dogs, so it could be effective for the prevention and treatment of acute myocardial ischemia.
Chen
J
J
Department of Pharmacology, School of Basic Medical Sciences, WCUMS, Chengdu 610041.
Cai
S
S
Li
S
S
Feng
Y
Y
Xie
R
R
D000818:Animals; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology*; D009206:Myocardium / Q000473:pathology
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal