Additional case of Ramichloridium mackenziei cerebral phaeohyphomycosis from the Middle East.
In this report we describe a case of cerebral phaeohyphomycosis involving a 56-year-old Egyptian male who worked as a mason in Kuwait for 6 years. Computerized tomography scan of the brain revealed presence of a large abscess in the left occipital lobe. Aspirated pus from the abscess showed branched, septate, hyphae with light brown pigmentation. Cultured pus grew the fungus Ramichloridium mackenziei. Despite amphotericin B (1 mg kg(-1) per day) therapy for 2 weeks, the patient expired. The isolate was later found to be resistant to amphotericin B ( > 32 microg ml(-1)). Antifungal susceptibility testing to other agents was also performed.
Khan
Z U
ZU
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat. ziauddin@hsc.k-univ.edu.kw
Lamdhade
S J
SJ
Johny
M
M
Al-Khalidi
J
J
Thussu
A
A
Yossef
H N
HN
Al-Obaid
I
I
Nasser
A A
AA
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification*; D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D004322:Drainage; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008877:Middle East; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery
D000935:Antifungal Agents; D000666:Amphotericin B