title: Muscle cramps in two standard poodles with hypoadrenocorticism.
abstract: Two standard poodles were evaluated for painful, episodic muscle cramps affecting their thoracic and pelvic limbs. Both dogs had been diagnosed with hypoadrenocorticism and were being treated with fludrocortisone acetate and prednisone when evaluated for muscle cramps. However, the muscle cramping started approximately 1 month prior to the diagnosis of hypoadrenocorticism. Findings on general physical examination included lethargy and dehydration. Neurological examination was normal between episodes. Serum biochemical abnormalities included hyperalbuminemia, azotemia, hyponatremia, hypochloremia, and hyperkalemia. Altering treatment to desoxycorticosterone pivalate resolved the electrolyte abnormalities and the episodes of muscle cramping in both dogs. The authors conclude that hypoadrenocorticism can be associated with episodes of painful muscle cramping in standard poodles.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
authors.forename: Miyoko
authors.initials: M
authors.lastname: Saito
authors.forename: Natasha J
authors.initials: NJ
authors.lastname: Olby
authors.forename: Leticia
authors.initials: L
authors.lastname: Obledo
authors.forename: Jody L
authors.initials: JL
authors.lastname: Gookin
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005121:Extremities; D005260:Female; D008297:Male; D009120:Muscle Cramp / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*
chemical_list: C019323:deoxycortone pivalate; D003900:Desoxycorticosterone