[The anxiety level and synthesis of neurosteroids in the brain of prenatally stressed male rats].
Prenatal stresses significantly reduce the anxiety level and enhance motor activity in mature male rats. An enhancement of the 5 alpha-reductase activity occurs in the hypothalamus, hippocampus, and the brain frontal cortx. The data obtained suggest that behavioural changes in mature male rats due to prenatal stresses may be a consequence of an increased forming of active progesterone metabolities in the brain.
Ordian
N E
NE
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg.
Pivina
S G
SG
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011374:Progesterone / Q000097:blood; D051381:Rats; D013256:Steroids / Q000096:biosynthesis*; D013312:Stress, Physiological / Q000503:physiopathology*
D013256:Steroids; D011374:Progesterone; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase