title: Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches.
abstract: Although signal transduction phenomena are well understood in vitro, their relevance for physiology and pathophysiology remains obscure. Recent years, however, have seen a plethora of attempts to link cell biochemistry and disease. At the Luxembourg conference it was attempted to link basal science to disease. In my presentation I focused on our research on stress activated kinases and other signalling elements in this respect in a variety of pro-inflammatory conditions. Knowledge of these pathways has now led to new therapeutic approaches, especially in Crohn's disease, which will be the subject of this commentary.
authors.affiliation: Laboratory for Experimental Internal Medicine, G2-133, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands.
authors.forename: Catherine
authors.initials: C
authors.lastname: van Montfrans
authors.forename: Maikel
authors.initials: M
authors.lastname: Peppelenbosch
authors.forename: Anje A
authors.initials: AA
authors.lastname: te Velde
authors.forename: Sander
authors.initials: S
authors.lastname: van Deventer
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003424:Crohn Disease / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D007249:Inflammation / Q000209:etiology; D007422:Intestines / Q000276:immunology; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000893:Anti-Inflammatory Agents; D020928:Mitogen-Activated Protein Kinases