[Comparative evaluation of the antiradical and antioxidant activity of estrogens and their nitro derivatives].
Estradiol, ethynylestradiol, and estradiol acetate possess antiradical activity (K7 = (1.8-2.0) x 10(-4) liter/mole sec). Nistranol exhibits antiradical properties only upon acid hydrolysis. The results of experiments with egg yolk liposomes showed evidence of a pronounced antioxidant activity of estradiol, ethynylestradiol, and estradiol nitrate, and the absence of such activity in nistranol. In the experiments on rat heart homogenates, nitroestrogens in a concentration of about 10(-4) M reduced the level of TBA-active products.
Matiushin
A I
AI
Molecular Pharmacology and Radiobiology Department, State Medical University, ul. Ostrovityanova 1, Moscow, 117437 Russia.
Gukasov
V M
VM
Rzheznikov
V M
VM
Balaban'ian
V Iu
VIu
Boĭko
M A
MA
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000737:chemistry; D004530:Egg Yolk / Q000737:chemistry; D004967:Estrogens / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes; D008163:Luminescent Measurements; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D013329:Structure-Activity Relationship
D000975:Antioxidants; D001555:Benzene Derivatives; D004967:Estrogens; D005609:Free Radicals; D008081:Liposomes; C015763:cumene