Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.
Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.
Allen
Todd M
TM
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. tallen2@partners.org
Jing
Peicheng
P
Calore
Briana
B
Horton
Helen
H
O'Connor
David H
DH
Hanke
Tomas
T
Piekarczyk
Marian
M
Ruddersdorf
Richard
R
Mothé
Bianca R
BR
Emerson
Carol
C
Wilson
Nancy
N
Lifson
Jeffrey D
JD
Belyakov
Igor M
IM
Berzofsky
Jay A
JA
Wang
Chenxi
C
Allison
David B
DB
Montefiori
David C
DC
Desrosiers
Ronald C
RC
Wolinsky
Steven
S
Kunstman
Kevin J
KJ
Altman
John D
JD
Sette
Alessandro
A
McMichael
Andrew J
AJ
Watkins
David I
DI
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002455:Cell Division; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology*; D008253:Macaca mulatta; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination
D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015395:Histocompatibility Antigens Class I; D016056:Immunodominant Epitopes; C110764:Mamu-A 01 antigen