title: Understanding predisposition to schizophrenia: toward intervention and prevention.
abstract: OBJECTIVE
  Early intervention to prevent schizophrenia is one of the most important goals of schizophrenia research. However, the field is not yet ready to initiate trials to prevent prodromal or psychotic symptoms in people who are at risk for developing the disorder. In this paper, we consider some of the major obstacles that must be studied before prevention strategies become feasible.
  
  
  RESULTS
  One of the most important hurdles is the identification of a syndrome or set of traits that reflects a predisposition to schizophrenia and that might provide potential targets for intervention. In a recent reformulation of Paul Meehl's concept of schizotaxia, we integrate research findings obtained over the last 4 decades to propose a syndrome with meaningful clinical manifestations. We review the conceptualization of this syndrome and consider its multidimensional clinical expression. We then describe preliminary research diagnostic criteria for use in adult, nonpsychotic, first-degree relatives of patients diagnosed with schizophrenia, based on negative symptoms and neuropsychological deficits. We follow this with evidence supporting the validity of the proposed syndrome, which mainly includes social dysfunction and response to a low dosage of one of the newer antipsychotic medications.
  
  
  CONCLUSIONS
  Continued progress toward the eventual initiation of prevention strategies for schizophrenia will include sustained efforts to validate the traits reflecting a predisposition to develop the disorder (for example, schizotaxia), follow-up studies to confirm initial findings, and the identification of potentially useful preventive interventions.
authors.affiliation: Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA. ming_tsuang@hms.harvard.edu
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: William S
authors.initials: WS
authors.lastname: Stone
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D001921:Brain / Q000002:abnormalities; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D011214:Practice, Psychological; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics / Q000517:prevention & control; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis; D012920:Social Behavior Disorders / Q000209:etiology