title: Cosmetic outcome and breast morbidity in breast-conserving treatment--results from the Danish DBCG-82TM national randomized trial in breast cancer.
abstract: A total of 266 recurrence-free breast cancer patients from the randomized DBCG-82TM breast conservation trial were called in for a follow-up investigation to study the impact of surgical and radiation treatment factors on the cosmetic and functional outcome after breast conservation. The patients were interviewed and examined after a median follow-up time of 6.6 years, and 194 of them (73%) regarded the cosmetic result as excellent or good. Morbidity assessments showed that breast fibrosis, skin telangiectasia, and breast retraction were significantly associated with a less satisfactory cosmetic result. On univariate analysis, it was found that treatment with a direct anterior electron field produced more morbidity and inferior cosmetic outcomes compared with tangential photon treatment, while increasing breast size was associated with increased breast retraction and breast fibrosis. Treatment characteristics that emerged as independent prognostic factors of a poor cosmetic outcome on multivariate analysis were the use of a direct anterior electron field (OR = 2.15, CI 1.25-3.70) and adjuvant systemic therapy (OR = 2.13, 1.22-3.71). A significant but relatively low level of concordance was found between the patients' and the clinician's evaluations of cosmetic results but self-assessments of breast morbidity and psychological distress were significantly related to the observed treatment-induced side effects after breast-conserving treatment, indicating that subjective perceptions and observations as reported by the patients are relevant for the identification of treatment factors that impact on normal tissue reactions.
authors.affiliation: Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus. j.johansen@dadlnet.dk
authors.forename: Jørgen
authors.initials: J
authors.lastname: Johansen
authors.forename: Jens
authors.initials: J
authors.lastname: Overgaard
authors.forename: Carsten
authors.initials: C
authors.lastname: Rose
authors.forename: Svend Aage
authors.initials: SA
authors.lastname: Engelholm
authors.forename: Carl C
authors.initials: CC
authors.lastname: Gadeberg
authors.forename: Mogens
authors.initials: M
authors.lastname: Kjaer
authors.forename: Claus
authors.initials: C
authors.lastname: Kamby
authors.forename: Jens
authors.initials: J
authors.lastname: Juul-Christensen
authors.forename: Mogens
authors.initials: M
authors.lastname: Blichert-Toft
authors.forename: Marie
authors.initials: M
authors.lastname: Overgaard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001504:Beauty; D001828:Body Image; D001943:Breast Neoplasms / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D017060:Patient Satisfaction; D012649:Self Concept; D013518:Surgery, Plastic; D015996:Survival Rate; D016896:Treatment Outcome