I-123-lodo-alpha-methyl tyrosine SPECT in non-parenchymal brain tumours.
OBJECTIVE
Scintigraphy using I-123-iodo-alpha-methyl tyrosine (IMT) is useful in the preoperative characterization of gliomas, in detecting recurrent glioma and in the biological re-evaluation of residual or recurrent tumours. A systematic evaluation of non-parenchymal brain tumours has not yet been performed. The aim of the present study was to evaluate IMT SPECT in the management of intracerebral metastases and lymphomas.


METHODS
IMT uptake was analyzed in 31 patients with 28 metastases of extracerebral solid tumours and 7 cerebral lymphomas. Histology revealed high grade lymphomas, melanomas, and carcinomas of the following origin: lung, unknown primary, breast, colon, renal cell, ovary, vagina, frontal sinus. IMT uptake was quantified as ratio between maximal tumour accumulation and average uptake in the contralateral hemisphere.


RESULTS
All tumours except two renal cell and one small cell lung carcinoma metastases accumulated IMT (91%). The highest IMT uptake was found in a metastasis of lung carcinoma. IMT uptake was highly variable and was similar in primary and in recurrent tumours.


CONCLUSIONS
Significant accumulation of IMT is seen in the majority of tumours, so that this technique might be helpful for the management of cerebral metastases and lymphomas.
Matheja
P
P
Department of Nuclear Medicine, University Hospital Münster, Germany.
Weckesser
M
M
Rickert
Ch
Ch
Franzius
Ch
Ch
Palkovic
St
S
Riemann
B
B
Schober
O
O
D000328:Adult; D000368:Aged; D001692:Biological Transport; D001706:Biopsy; D001932:Brain Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D005910:Glioma / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008223:Lymphoma / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D019805:alpha-Methyltyrosine / Q000493:pharmacokinetics
D007457:Iodine Radioisotopes; D019805:alpha-Methyltyrosine