Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of scavenger receptor BI without affecting bile acid biosynthesis in hamsters.
The purpose of this study was to analyze the effects of increasing amounts of dietary myristic acid (0.03 to 4.2% of the total dietary energy) on the plasma and hepatic cholesterol metabolism. Six groups of hamsters received semi-purified diets containing 0.05% cholesterol and 12.5% lipids and differing only by the nature of the triglycerides (Safflower oil, lard, lard/coconut oil (1:1), milk fat, milk fat/coconut oil (1:1), coconut oil) for 3 weeks. A positive regression between the plasma cholesterol level and the dietary myristic acid level was observed (r = 0.60, P < 0.0001). However, it is noteworthy that the increase in plasma total cholesterol only reflects an increase in the level of HDL-cholesterol. In parallel, the mass SR-BI decreased linearly with the increased level of myristic acid in the diet, whereas the LDL-R did not change. This study shows that increasing amounts of myristic acid (0.03 to 4.2%) do not alter the cholesterol or bile acid metabolism and increase only the HDL-C.
Loison
Carole
C
Laboratoire de Physiologie de la Nutrition, Université Paris-Sud, Centre d'Orsay, France.
Mendy
François
F
Serougne
Colette
C
Lutton
Claude
C
D000284:Administration, Oral; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D018955:CD36 Antigens / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D006224:Cricetinae; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins; D008647:Mesocricetus; D019814:Myristic Acid / Q000008:administration & dosage* / Q000378:metabolism; D011897:Random Allocation; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D001647:Bile Acids and Salts; D018955:CD36 Antigens; D008076:Cholesterol, HDL; D004041:Dietary Fats; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D019814:Myristic Acid; D002784:Cholesterol