Ulcerative colitis in monozygotic twin sisters.
We present a rare occurrence of woman monozygotic twins with ulcerative colitis (UC). A 21-year-old woman came to our hospital because of diarrhea, abdominal pain and hematochezia. We diagnosed this case as proctitis type UC by endoscopic and histological findings. Six months later, her twin sister developed total colitis type UC. Both twins had HLA-A24, B52, DR2, and DQ1 serological types, and had DRB1*1502 DNA type, previously shown to be associated with UC. This case report suggested an association of genetic factor together with environmental factors in the etiology for UC.
Iwaizumi
Moriya
M
Department of Gastroenterology, Hamamatsu Medical Center.
Yamada
Masami
M
Kitagawa
Mutsuo
M
Takehira
Yasunori
Y
Hanajima
Kazunori
K
Murohisa
Gou
G
Kawamura
Motoko
M
Iwaoka
Yasushi
Y
Wada
Tomohiko
T
Morita
Satoru
S
Kawata
Kazuhito
K
D000328:Adult; D003093:Colitis, Ulcerative / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D004247:DNA / Q000235:genetics; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D012307:Risk Factors; D014430:Twins, Monozygotic
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA