title: Novel and potent anti-malarial agents.
abstract: Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.
authors.affiliation: Center for New Directions in Organic Synthesis, Chemistry Department, University of California, Berkeley, CA 94720, USA.
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Brinner
authors.forename: Jin
authors.initials: J
authors.lastname: Mi Kim
authors.forename: Hiromu
authors.initials: H
authors.lastname: Habashita
authors.forename: Ilya Y
authors.initials: IY
authors.lastname: Gluzman
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Goldberg
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ellman
mesh_terms: D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D007202:Indicators and Reagents; D002738:Chloroquine