Fluoroquinolone-resistant Streptococcus pneumoniae strains occur frequently in elderly patients in Japan.
We identified and genetically characterized seven fluoroquinolone-resistant Streptococcus pneumoniae strains among 293 clinical strains isolated from 1999 to 2001 in Japan. The resistant strains were isolated only from adults, and 7 of 31 isolates (22.6%) were from patients more than 20 years old. Resistant strains were not found in 262 isolates from children under age 10.
Yokota
Shin-Ichi
S
Department of Microbiology, Sapporo Medical University School of Medicine, Chuo-ku, Japan.
Sato
Kiyoshi
K
Kuwahara
Osamu
O
Habadera
Satoshi
S
Tsukamoto
Naoyuki
N
Ohuchi
Hironori
H
Akizawa
Hirotsugu
H
Himi
Tetsuo
T
Fujii
Nobuhiro
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D017422:Sequence Analysis, DNA; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase