Functional genomics in neuropsychiatric disorders and in neuropharmacology.
The rapidly accumulating amount of information concerning gene and protein expression patterns produced by functional genomics, proteomics and bioinformatics is presently providing new targets for drug development. Furthermore, the analysis of gene expression in cells and tissues affected by a disease may reveal the underlying metabolic pathways and cellular processes affected. Finally, changes in gene expression may be used in either diagnostics or the monitoring of drug responses. This review focuses on advances in the use of functional genomics in neurological and neuropsychiatric diseases and neuropsychopharmacology. Although the number of published studies in this field is still limited, it already appears that this strategy may become a fruitful means in the analysis of the aetiology of neuropsychiatric disorders and the search for novel neuropharmacological drugs.
Kontkanen
Outi
O
Department of Neurobiology, A.I. Virtanen Institute and Department of Psychiatry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland.
Castrén
Eero
E
D002491:Central Nervous System Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015195:Drug Design; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000187:drug effects; D023281:Genomics; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects / Q000494:pharmacology; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000235:genetics; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics; D009480:Neuropharmacology / Q000379:methods*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D019966:Substance-Related Disorders / Q000235:genetics
D002491:Central Nervous System Agents; D013287:Illicit Drugs; D009419:Nerve Tissue Proteins