[Adaptability of Opisthorchis felineus metacercariae as a result of altered phagocytic activity of polymorphonuclear neutrophils].
The higher absorptivity of neutrophils during their alpha-tocopherol stimulation has been found to promote lower adaptability in the metacercariae of Opisthorchis felineus, a reverse picture was observed when cyclophosphanum was used. The antihelminthic effect of biltricide is probably to be unassociated with the changed functional activity of polymorphonuclear leukocytes, but to be determined by its direct action on helminths. This phenomenon was studied on golden hamsters inoculated with Opisthorchis felineus. On day 2 after inoculation, the following drugs were given for a fortnight: biltricide in a single dose of 60 mg/kg weight; biltricide used in a daily fractionated dose of 60 mg/kg; cyclophosphanum (6 mg/kg, every second day); alpha-tocopherol in a daily dose of 30 mg every day.
Iakovleva
V V
VV
Stepanova
T F
TF
Sozonova
T A
TA
Rybakova
M V
MV
Parfenova
G V
GV
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D006224:Cricetinae; D003520:Cyclophosphamide / Q000008:administration & dosage; D004195:Disease Models, Animal; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D008018:Life Cycle Stages; D008099:Liver / Q000469:parasitology; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D009889:Opisthorchiasis / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology; D009891:Opisthorchis / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000627:therapeutic use
D000871:Anthelmintics; D000975:Antioxidants; D007166:Immunosuppressive Agents; D011223:Praziquantel; D003520:Cyclophosphamide; D024502:alpha-Tocopherol