Cytotoxic sesquiterpene lactones from Carpesium abrotanoides.
Eight sesquiterpene lactones, 4 alpha,5 alpha-epoxy-10 alpha,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1 - 8 showed significant cytotoxic activity (ED50 values, < 20 microM) against all tumor call lines tested. Among these compounds, 4 alpha,5 alpha-epoxy-10 alpha,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED50, < 10 microM) comparable to that of cisplatin.
Lee
JunSung
J
College of Pharmacy, Chungnam National University, Taejon, Korea.
Min
ByungSun
B
Lee
SangMyung
S
Na
MinKyun
M
Kwon
ByungMok
B
Lee
ChongOck
C
Kim
YoungHo
Y
Bae
KiHwan
K
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D007783:Lactones; D012717:Sesquiterpenes