Immature-like astrocytes are associated with dentate granule cell migration in human temporal lobe epilepsy.
In human temporal lobe epilepsy, a dispersion of dentate granule cells is frequently described in adults who had an early risk factor. To elucidate the role of glia in this phenomenon, we investigated neuronal dispersion, astrocyte organization and expression of intermediate filaments of mature and immature astrocytes (i.e. glial fibrillary acidic protein (GFAP) and vimentin, respectively) in seven subjects with early febrile seizures (F(+)) and five subjects with other etiologies than febrile seizures (F(-)). Compared to F(-) patients, a majority of F(+) subjects showed neuronal dispersion and vimentin expression in radial glia. However, in two patients with the maximal dispersion, radial processes expressed only GFAP. We suggest that granule cell migration that occurs in adult epileptic focus results from the transient occurrence of immature-like glia throughout the granular layer.
Crespel
Arielle
A
UPR CNRS 9023, CCIPE, Montpellier, France. a-crespel@chu-montpellier.fr
Coubes
Philippe
P
Rousset
Marie-Claude
MC
Alonso
Gérard
G
Bockaert
Joël
J
Baldy-Moulinier
Michel
M
Lerner-Natoli
Mireille
M
D000328:Adult; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D002465:Cell Movement; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D014746:Vimentin / Q000096:biosynthesis
D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin