title: Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome.
abstract: BACKGROUND
  To investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia.
  
  
  METHODS
  Prospective study of the adverse effects of IV lignocaine in 106 patients with fibromyalgia; retrospective questionnaire study of the efficacy of IV lignocaine in 50 patients with fibromyalgia.
  
  
  RESULTS
  Prospective study: Two major (pulmonary oedema and supraventricular tachycardia) and 42 minor side-effects were reported. None had long-term sequelae. The commonest was hypotension (17 cases). Retrospective study: Pain and a range of psychosocial measures (on single 11-point scales) improved significantly after treatment. There was no effect of the treatment on work status. The average duration of pain relief after the 6-day course of treatment was 11.5 +/- 6.5 weeks.
  
  
  CONCLUSIONS
  Intravenous lignocaine appears to be both safe and of benefit in improving pain and quality of life for patients with fibromyalgia. This needs to be confirmed in prospective randomised controlled trials.
authors.affiliation: Department of Pain Management, Dudley Group of Hospitals NHS Trust, West Midlands, UK. JonRaph@AOL.com
authors.forename: J H
authors.initials: JH
authors.lastname: Raphael
authors.forename: J L
authors.initials: JL
authors.lastname: Southall
authors.forename: G J
authors.initials: GJ
authors.lastname: Treharne
authors.forename: G D
authors.initials: GD
authors.lastname: Kitas