title: Assembling the human immunodeficiency virus type 1.
abstract: Retroviral assembly proceeds through a series of concerted events that lead to the formation and release of infectious virion particles from the infected cell. Upon translation, structural proteins are targeted to the plasma membrane where they accumulate. There, the nascent particle forces the plasma membrane to form a bud, which pinches off releasing the virion particle from the cell. In this review we describe the molecular mechanisms now known to be behind the process of virion assembly. In particular, we focus on the human immunodeficiency virus type 1, the prototype member of the lentivirus subfamily of the Retroviridae.
authors.affiliation: U412, Laborétro, Ecole Normale Supérieure de Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Cimarelli
authors.forename: J L
authors.initials: JL
authors.lastname: Darlix
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D015686:Gene Products, env / Q000378:metabolism; D015683:Gene Products, gag / Q000737:chemistry / Q000378:metabolism; D016346:Gene Products, vif / Q000378:metabolism; D005814:Genes, Viral; D015497:HIV-1 / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity; D054298:Human Immunodeficiency Virus Proteins; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D012367:RNA, Viral / Q000378:metabolism; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism; D014771:Virion / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity; D054320:vif Gene Products, Human Immunodeficiency Virus; D000086082:Viroporin Proteins
chemical_list: D015686:Gene Products, env; D015683:Gene Products, gag; D016346:Gene Products, vif; D054298:Human Immunodeficiency Virus Proteins; D012367:RNA, Viral; D054334:Viral Regulatory and Accessory Proteins; D054320:vif Gene Products, Human Immunodeficiency Virus; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins