[Levodopa dependency in Parkinson's disease: case report and review].
Only a few patients with Parkinson's disease and levodopa dependency or abuse have been reported. We present a 35-year-old patient with young-onset Parkinson's disease who developed motor complications, levodopa dependency, and drug-induced psychosis after primary treatment with levodopa. Diagnostic criteria and treatment guidelines for this neuropsychiatric disorder are presented as well as a tentative neurobiological answer to the question of why levodopa dependency is observed only in a minority of patients with Parkinson's disease.
Müller
U
U
Klinik und Poliklinik für Psychiatrie, Universität Leipzig, Germany. muelleru@cns.mpg.de
Reuter
M
M
Hermann
W
W
Gertz
H J
HJ
D000328:Adult; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects; D008032:Limbic System / Q000187:drug effects; D008297:Male; D008609:Mental Status Schedule; D008636:Mesencephalon / Q000187:drug effects; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology / Q000534:rehabilitation; D010348:Patient Care Team; D011605:Psychoses, Substance-Induced / Q000175:diagnosis* / Q000523:psychology / Q000534:rehabilitation; D011954:Receptors, Dopamine / Q000187:drug effects; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology / Q000534:rehabilitation
D000978:Antiparkinson Agents; D011954:Receptors, Dopamine; D007980:Levodopa