Modulation of axonal regeneration in neurodegenerative disease: focus on Nogo.
Recent work has demonstrated that axonal regeneration in the central nervous system is limited by myelin-derived Nogo binding to an axonal Nogo Receptor. The Nogo system appears to have a physiologic role in regulating structural plasticity. The possibility that the Nogo system contributes to pathologic and compensatory plasticity in Alzheimer's Disease is considered.
Strittmatter
Stephen M
SM
Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA. Stephen.Strittmatter@yale.edu
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology*; D058851:GPI-Linked Proteins; D006131:Growth Inhibitors / Q000378:metabolism*; D009185:Myelin Proteins / Q000378:metabolism*; D009186:Myelin Sheath / Q000473:pathology; D009416:Nerve Regeneration; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology*; D009473:Neuronal Plasticity; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; D011956:Receptors, Cell Surface / Q000378:metabolism
D058851:GPI-Linked Proteins; D006131:Growth Inhibitors; D009185:Myelin Proteins; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; D011956:Receptors, Cell Surface; C000603201:Rtn4 protein, mouse; C419790:Rtn4r protein, mouse