Associative pullulan gels and their interaction with biological active substances.
This paper studies the synthesis and properties of anionic and/or amphiphilic pullulan microparticles crosslinked with epichlorohydrine or with sodium trimethaphosphate. The polysaccharide gels were physicochemically characterized and their interaction with enzymes (lysozyme) was studied with the aim to appreciate the performances for separation/purification/immobilization of the enzymes or controlled release drug systems.
Mocanu
G
G
Petru Poni Institute of Macromolecular Chemistry, Aleea Gr Ghica Voda Nr 41, 6600 Iasi, Romania. gmocanu@poni.icmpp.tuiasi.ro
Mihai
D
D
Picton
L
L
LeCerf
D
D
Muller
G
G
D003432:Cross-Linking Reagents / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels; D005936:Glucans / Q000737:chemistry / Q000493:pharmacokinetics*; D008863:Microspheres; D009113:Muramidase / Q000737:chemistry / Q000493:pharmacokinetics*
D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005782:Gels; D005936:Glucans; C009109:pullulan; D009113:Muramidase