title: Clear cell odontogenic carcinoma: report of a case and analysis of the literature.
abstract: BACKGROUND
  Clear cell odontogenic carcinoma (CCOC), which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases.
  
  
  OBJECTIVE
  To report the clinicopathologic findings and follow-up of a case of CCOC and to review the literature.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  Findings from histologic analysis, immunohistochemistry, and electron microscopy.
  
  
  RESULTS
  An 81-year-old woman experienced 3 locoregional recurrences within 21 months of initial therapy. She is presently disease free, 4.5 years after initial resection, having received multiple resections and adjuvant radiotherapy.
  
  
  CONCLUSIONS
  The diagnosis of CCOC must be considered in the differential diagnosis of jaw tumors with a clear cell component. For these tumors, resection with negative margins is the treatment of choice because more conservative surgery (eg, curettage) inevitably results in recurrence and/or metastasis. Adjuvant radiotherapy is a rational option for tumors that have eroded cortex.
authors.affiliation: Department of Pathology, Box 1189, Mount Sinai Medical Center, New York, NY, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Brandwein
authors.forename: Nasser
authors.initials: N
authors.lastname: Said-Al-Naief
authors.forename: Ron
authors.initials: R
authors.lastname: Gordon
authors.forename: Mark
authors.initials: M
authors.lastname: Urken
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D009808:Odontogenic Tumors / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D011859:Radiography