title: Hydraulic functional characterisation of aortic mechanical heart valve prostheses through lumped-parameter modelling.
abstract: Lumped-parameter modelling techniques are proposed as a method for studying the hydraulic characteristics of mechanical prosthetic heart valves (PHVs). The global hydraulic behaviour of PHVs in the open position was modelled by taking into account the (nonlinear) resistive and (linear) inertial factors governing the time-dependent relationship between transvalvular pressure drop and fluid flow rate, and neglecting the leaflets' opening and closure transient phenomena. Statistically defined indices associated to the parameters' values attest how properly the model describes PHV hydraulic behaviour. Local fluid dynamics is not modelled with this approach. The proposed method was implemented in a software program and applied to the characterisation of the aortic StJude Medical, StJude Medical Hemodynamic Plus and CarboMedics PHVs, basing on steady- and pulsatile-flow hydraulic-bench experimental data. The results showed that reliable parameters expressing hydraulic resistance can be derived from steady-flow data (R(2)>0.995). Inertance parameters derived from pulsatile-flow experiments are liable to a degree of uncertainty (confidence intervals up to 17%), however, comparing the reconstructed vs. measured pressure drop during systolic time demonstrates that this deficiency is mostly due to the missing description of initial, transient oscillations presumably related to the leaflets' opening (not modelled).
authors.affiliation: Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milano, Italy. fiore@biomed.polimi.it
authors.forename: G B
authors.initials: GB
authors.lastname: Fiore
authors.forename: M
authors.initials: M
authors.lastname: Grigioni
authors.forename: C
authors.initials: C
authors.lastname: Daniele
authors.forename: G
authors.initials: G
authors.lastname: D'Avenio
authors.forename: V
authors.initials: V
authors.lastname: Barbaro
authors.forename: R
authors.initials: R
authors.lastname: Fumero
mesh_terms: D001021:Aortic Valve / Q000601:surgery*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001809:Blood Viscosity; D003198:Computer Simulation; D019544:Equipment Failure Analysis / Q000379:methods*; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design / Q000379:methods; D011673:Pulsatile Flow; D012680:Sensitivity and Specificity