[A study on nasal absorption of psoralen and isopsoralen in Psoralea corylifolia L].
OBJECTIVE
To investigate the nasal absorption regularities of psoralen and isopsoralen of different concentrations.


METHODS
Building an experimental model of rat in situ nasal recirculation and determining the contents of psoralen and isopsoralen by HPLC.


RESULTS
The nasal absorption of psoralen and isopsoralen fitted in with zero order kinetics, getting saturated with the increase of concentration.


CONCLUSIONS
A suitable concentration is necessary for the preparation of nasal remedies psoralen and isopsoralen.
Li
A
A
Central Laboratory of Guangdong Provincial Hospital of TCM, Guangzhou 510120.
Wang
H
H
D000042:Absorption; D000818:Animals; D005260:Female; D005363:Ficusin / Q000302:isolation & purification / Q000493:pharmacokinetics*; D011564:Furocoumarins / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D029907:Psoralea / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D011564:Furocoumarins; C011659:angelicin; D005363:Ficusin