The differential effect of haloperidol and repetitive induction on four immobility responses in mouse and guinea pig.
The modification by haloperidol and repetitive induction on four immobility responses -- tonic immobility, cataleptic immobility, immobility by clamping the neck and dorsal immobility -- were compared in mice and guinea pigs. Without drug, three out of four responses (cataleptic, neck clamp and dorsal immobility) were induced in mice; guinea pigs displayed all four responses. Haloperidol (5 mg/kg i.p.) potentiated the three responses shown by mice, but did not potentiate the four responses in guinea pigs. In both undrugged and haloperidol-treated mice, only the cataleptic immobility response was potentiated by repetition. In guinea pigs, none of the four immobility responses was affected due to repetition, haloperidol or a combination of both. These data are discussed, considering that, although these immobility responses could be mediated by the same neurotransmitters (e.g. dopamine), they are possibly expressed in a differential manner as a function of the kind of stimulus used to trigger the response, characteristics of the species and, in some immobility responses such as cataleptic immobility, as a function of their interaction with habituation or another learning-like process.
Fregoso-Aguilar
T
T
Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Mexico.
Urióstegui
T
T
Zamudio
S
S
De la Cruz
F
F
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000523:psychology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D006168:Guinea Pigs; D006220:Haloperidol / Q000494:pharmacology*; D007103:Immobilization; D007858:Learning / Q000187:drug effects; D008297:Male; D051379:Mice; D011187:Posture; D013045:Species Specificity; D013315:Stress, Psychological / Q000523:psychology*
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D006220:Haloperidol