title: Renal graft failure after addition of an angiotensin II receptor antagonist to an angiotensin-converting enzyme inhibitor: unmasking of an unknown iliac artery stenosis.
abstract: Combined treatment with an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II (Ang II) receptor blocker (ARB) has been suggested in order to achieve a more complete blockade of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. The present report describes a case of acute renal graft dysfunction following the addition of an ARB to existing ACE inhibition. This unmasked an unknown iliac artery stenosis. The case indicates a possible important role of Ang II generated by non-ACE pathways in this situation.
authors.affiliation: Department of Nephrology, Herlev Hospital, Denmark. ankam@herlevhosp.kbhamt.dk
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Kamper
authors.forename: Arne Høj
authors.initials: AH
authors.lastname: Nielsen
authors.forename: Niels
authors.initials: N
authors.lastname: Baekgaard
authors.forename: Svend
authors.initials: S
authors.lastname: Just
mesh_terms: D000792:Angiography; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001157:Arterial Occlusive Diseases / Q000473:pathology*; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007083:Iliac Artery / Q000473:pathology*; D016030:Kidney Transplantation; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors