The use of imatinib (STI571) in chronic myelod leukemia: some practical considerations.
OBJECTIVE
The new Abl tyrosine kinase inhibitor imatinib (imatinib mesylate, STI571) is very effective in the treatment of patients with chronic myeloid leukemia (CML). It induces complete hematologic control in >90% of patients with CML in chronic phase and preliminary data suggest that the incidence of complete cytogenetic remission may exceed 60% in previously untreated patients, though its capacity to prolong life in comparison with other agents has not yet been clearly established. It is also active in the management of patients in advanced phases of CML.


METHODS
We present here provisional indications for the use of imatinib in CML patients and give details of the dosage regimens we have used and side-effects we have encountered.


CONCLUSIONS
It is likely that the optimal usage of this important new agent will become better defined as more experience is gained.
Marin
David
D
Marktel
Sarah
S
Bua
Marco
M
Armstrong
Lorraine
L
Goldman
John M
JM
Apperley
Jane F
JF
Olavarria
Eduardo
E
D001549:Benzamides; D018450:Disease Progression; D004347:Drug Interactions; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011743:Pyrimidines / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome
D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate