title: Location-guided screening of liquid-based cervical cytology specimens: a potential improvement in accuracy and productivity is demonstrated in a preclinical feasibility trial.
abstract: A 2-armed, masked study was performed on 1,275 AutoCyte PREP (TriPath, Burlington, NC) slides. Manual screening (current practice [CP]) was compared with automated screening with location-guided screening (LGS) using the AutoPap system with the SlideWizard 2 automated review microscopy station (TriPath). Cytologic adjudication determined "truth" for each slide. LGS identified more abnormal cases at all interpretive levels and classified abnormalities more specifically. For high-grade squamous intraepithelial lesions and above, the overall sensitivity of appropriate triage to pathologist review was 98.4% for LGS and 91.1% for CP. The appropriate triage for all abnormal cases was 92.1% for LGS and 87.9% for CP. The potential exists for more accurate and productive cytologic interpretation using this system, which requires no manual screening of a portion of slides and only limited review of another portion of "predotted" slides.
authors.affiliation: Cytopathology Unit, ViaHealth, Rochester, NY, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Wilbur
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Parker
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Foti
mesh_terms: D001331:Automation; D003936:Diagnosis, Computer-Assisted; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D013048:Specimen Handling / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000517:prevention & control*; D014626:Vaginal Smears / Q000379:methods*