Talking the talk: the role of VEGF proteins in cell signaling.
Vascular endothelial growth factors (VEGFs) stimulate endothelial cell growth through interactions with their tyrosine kinase receptors to stimulate intracellular signaling events. This culminates in the expression of specific gene products that induce a cellular response in numerous physiological processes, including hematopoeisis, oncogenesis and embryogenesis. The primordial function of VEGF can be revealed by studying VEGF-mediated signaling pathways in the powerful and tractable model system, Drosophila melanogaster, which has proved invaluable in furthering our understanding of conserved developmental themes.
Leal
Sandra M
SM
Neckameyer
Wendi S
WS
D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D004331:Drosophila melanogaster / Q000196:embryology; D016228:Endothelial Growth Factors / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D008222:Lymphokines / Q000502:physiology*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors