title: Synthesis and mannose receptor-mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge.
abstract: Effect of charge and shape of multivalent lysine-based cluster glycomimetics on their mannose receptor-mediated uptake by human dendritic cells has been evaluated: The capture is strongly affected by the shape of the ligands. The effect of charge is less pronounced although positive charges on the ligands seem to favor non-specific endocytosis capture.
authors.affiliation: SEDAC-Therapeutics, Parc Eurasanté, Le Galenis, Bât B, 85 rue Nelson Mandela, 59120 Loos, France.
authors.forename: Gerhild
authors.initials: G
authors.lastname: Angyalosi
authors.forename: Cyrille
authors.initials: C
authors.lastname: Grandjean
authors.forename: Mélanie
authors.initials: M
authors.lastname: Lamirand
authors.forename: Claude
authors.initials: C
authors.lastname: Auriault
authors.forename: Hélène
authors.initials: H
authors.lastname: Gras-Masse
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk
mesh_terms: D003713:Dendritic Cells / Q000187:drug effects*; D005434:Flow Cytometry; D019793:Fluorescein; D005947:Glucose / Q000494:pharmacology*; D037181:Lectins, C-Type; D008024:Ligands; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D018716:Molecular Mimicry; D011801:Quinic Acid / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000187:drug effects*; D012765:Shikimic Acid / Q000494:pharmacology
chemical_list: D037181:Lectins, C-Type; D008024:Ligands; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D011801:Quinic Acid; D012765:Shikimic Acid; D005947:Glucose; D019793:Fluorescein