title: Isolated autonomic cardiovascular neuropathy in a patient with primary Sjögren syndrome: a case of successful treatment with glucocorticoid.
abstract: Autonomic failure is rare in patients with Sjögren syndrome (SS). We report the case of a 46-year-old woman with severe autonomic cardiovascular failure, manifested by incapacitating postural hypotension, as the first symptom of primary SS. Treatment with glucocorticoid resulted in a dramatic improvement of her symptoms and objective findings of autonomic cardiovascular dysfunction. We suggest that SS should be considered in patients with idiopathic autonomic cardiovascular neuropathy, especially in those with idiopathic orthostatic hypotension. Furthermore, glucocorticoid therapy seems to be very efficacious in the treatment of SS-associated autonomic cardiovascular neuropathy.
authors.affiliation: Department of Medicine I, Tottori University Faculty of Medicine, Yonago, Japan. masaki-tky@umin.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimoyama
authors.forename: Akira
authors.initials: A
authors.lastname: Ohtahara
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Okamura
authors.forename: Masashi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Sachiko
authors.initials: S
authors.lastname: Teshima
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hisatome
authors.forename: Chiaki
authors.initials: C
authors.lastname: Shigamasa
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000188:drug therapy*; D002319:Cardiovascular System / Q000294:innervation*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007022:Hypotension / Q000150:complications; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications* / Q000188:drug therapy*
chemical_list: D005938:Glucocorticoids