title: Initial report of bladder carcinoma following combined bladder-drained pancreas and kidney transplantation.
abstract: Although long-term survival of a functional allograft requiring long-term immunosuppressive therapy is responsible for higher incidence of non-urothelial cancers in renal allograft recipients than in normal population, the incidence of bladder cancer is uncommon and carcinoma of the bladder in the setting of combined kidney-pancreas transplantation has not been reported to date. We herein report a case of poorly differentiated invasive adeno-squamous cell carcinoma of the bladder following renal and bladder-drained pancreatic transplantation in a 44-yr-old lady with long-standing insulin dependent diabetes mellitus, which necessitated radical extirpation. Management implications are reviewed.
authors.affiliation: Department of Urology, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Highshaw
authors.forename: Hari S G R
authors.initials: HS
authors.lastname: Tunuguntla
authors.forename: Richard V
authors.initials: RV
authors.lastname: Perez
authors.forename: Regina
authors.initials: R
authors.lastname: Gandour-Edwards
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Evans
mesh_terms: D000328:Adult; D018196:Carcinoma, Adenosquamous / Q000150:complications / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000379:methods; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000209:etiology* / Q000628:therapy