[Study on the contents of serum HDL subclasses in type N hyperlipidemics].
Contents of serum HDL subclasses in normolipidemics (n = 24) and type IV hyperlipidemics (n = 24) were determined using two-dimensional gel electrophoresis associated with immunodetection method. The results showed that the contents of pre-beta 1 HDL (P < 0.001) and HDL3a (P < 0.05) increased significantly and that of HDL2b (P < 0.001) decreased significantly in hyperlipidemics, compared with normolipidemics. Serum TG concentrations of hyperlipidemics showed positive correlation with pre-beta 1 HDL (r = 0.582) and HDL3a (r = 0.692) and negative correlation with HDL2b (r = -0.506) and HDL2a (r = -0.552). These results indicated that the maturation of HDL could be abnormal in type IV hyperlipidemics.
Wu
X
X
Apolipoprotein Research Laboratory, School of Basic Medical Sciences, WCUMS, Chengdu 610041.
Fu
M
M
Liu
B
B
D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D053442:High-Density Lipoproteins, Pre-beta; D006801:Humans; D006953:Hyperlipoproteinemia Type IV / Q000097:blood* / Q000145:classification; D008075:Lipoproteins, HDL / Q000097:blood / Q000145:classification*; D053440:Lipoproteins, HDL3; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D053442:High-Density Lipoproteins, Pre-beta; D008075:Lipoproteins, HDL; D053440:Lipoproteins, HDL3; D008079:Lipoproteins, VLDL; D014280:Triglycerides