title: Prevalence of Helicobacter pylori infection and its link to coronary risk factors in Japanese patients with acute myocardial infarction.
abstract: The association between Helicobacter pylori (H. pylori) infection and coronary artery disease, as well as the association between H. pylori infection and classic coronary risk factors, is controversial in patients from Western countries. The high prevalence of H. pylori infection in Japanese subjects enables an examination of these associations in a large population, especially in young patients, because coronary risk factors may be more strongly associated with younger individuals than with older individuals. The IgG seropositivity to H. pylori was assessed in 618 cases with acute myocardial infarction (AMI) and in 967 controls. The prevalence of seropositivity to H. pylori was similar between cases and controls, but in subjects younger than 55 years, the rate was significantly higher in cases than in controls (58.7% vs 43.3%, p = 0.009). After adjustment for age, gender, diabetes mellitus, hypertension, smoking, body mass index, total cholesterol, and high density lipoprotein cholesterol, the odds ratio for acute myocardial infarction was 2.97 (95% confidence interval, 1.37-6.41; p = 0.006). Worsening of classic coronary risk factors was not associated with H. pylori infection in subjects younger than 55 years. These results suggest that in younger individuals in Japan, H. pylori infection is significantly associated with AMI independent of the classic coronary risk factors.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kinjo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Sato
authors.forename: Issei
authors.initials: I
authors.lastname: Shiotani
authors.forename: Toshiya
authors.initials: T
authors.lastname: Kurotobi
authors.forename: Yozo
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Eiji
authors.initials: E
authors.lastname: Hishida
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nakatani
authors.forename: Hiroya
authors.initials: H
authors.lastname: Mizuno
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sasaki
authors.forename: Akio
authors.initials: A
authors.lastname: Kohama
authors.forename: Yukichi
authors.initials: Y
authors.lastname: Abe
authors.forename: Hisaki
authors.initials: H
authors.lastname: Morita
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D015995:Prevalence; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G