title: Angiopoietin-1 and vascular endothelial growth factor expression in human esophageal cancer.
abstract: Angiopoietin-1 (Ang-1) has been shown to act as an angiogenic promoter in embryonic angiogenesis by promoting vascular branching, pericyte recruitment and endothelial survival. Ang-1 expression has not been examined in human esophageal cancer. We examined Ang-1 and vascular endothelial growth factor (VEGF) gene expression in tumors from 45 esophageal cancer patients who underwent surgical resection. Forty (88.9%) of the 45 esophageal cancers revealed Ang-1 gene expression. VEGF121, VEGF165 and VEGF189 isoforms were detected in 93.3 (42/45), 55.6 (25/45) and 26.7% (12/45) of the cases, respectively. Ang-1 gene expression was significantly correlated with VEGF121 and VEGF165 gene expression (P=0.0289 and P=0.0127, respectively, Fisher's test). The results suggest that Ang-1 is associated with neovascularization in the cancer stroma through VEGF net-works in esophageal cancer.
authors.affiliation: Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa 259-1193, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Nagata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hatanaka
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Tokunaga
authors.forename: Junichiro
authors.initials: J
authors.lastname: Kamochi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Abe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takagi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mine
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ueyama
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000096:biosynthesis / Q000235:genetics*; D042683:Angiopoietin-1; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000096:biosynthesis / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis / Q000235:genetics*; D008222:Lymphokines / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: C467630:ANGPT1 protein, human; D043925:Angiogenesis Inducing Agents; D042683:Angiopoietin-1; D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D008562:Membrane Glycoproteins; D020033:Protein Isoforms; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors