[The relationship between bone mineral density and secondary hyperparathyroidism bone disease].
The bone mineral density (BMD) and Z score in distal 1/3 radius were measured with dual energy X-ray absorptiometry (DEXA) in 185 hemodialysis (HD) patients, meanwhile serum parathyroid hormone (PTH), alkaline phosphatase (ALP) and hand X-rays were detected. Results showed that BMD in HD patients was significantly lower than that in control group(P < 0.05), and decreased with dialysis duration increasing. BMD in HD patients was negatively related with PTH, ALP and rate of subperiosteal erosions. By using Z score to diagnose hyperparathyroidism bone disease, receiver operating characteristic (ROC) curve was worked out. If Z score < or = -2.02, the sensitivity was 79.41% and specificity was 78.15%. In conclusion the measurement of BMD is a useful tool for the detection of hyperparathyroid bone disease.
Ning
J P
JP
Department of Nephrology, Xianya Hospital, Hunan Medical University, Changsha 410008.
Sun
M
M
Toru
I
I
Etsuo
Y
Y
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D015519:Bone Density; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis
D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase