title: Further halotyrosine derivatives from the marine sponge Suberea aff. praetensa.
abstract: Reexamination of the marine sponge Suberea aff. praetensa, (Row) from the Gulf of Thailand furnished in addition to bromotyrosine derivatives found previously 5-bromo- and 5-chlorocavernicolin, cavernicolins 1 and 2, two other brominated tyrosine metabolites, a known bisoxazolidone and a new unusual rearranged tyrosine metabolite subereatensin. Several of the metabolites exhibited significant inhibitory effects against five human cancer cell lines.
authors.affiliation: Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Portugal.
authors.forename: Anake
authors.initials: A
authors.lastname: Kijjoa
authors.forename: Rawiwan
authors.initials: R
authors.lastname: Watanadilok
authors.forename: Pichai
authors.initials: P
authors.lastname: Sonchaeng
authors.forename: Pichan
authors.initials: P
authors.lastname: Sawangwong
authors.forename: Madalena
authors.initials: M
authors.lastname: Pedro
authors.forename: Maria São José
authors.initials: MS
authors.lastname: Nascimento
authors.forename: Artur M S
authors.initials: AM
authors.lastname: Silva
authors.forename: Graham
authors.initials: G
authors.lastname: Eaton
authors.forename: Werner
authors.initials: W
authors.lastname: Herz
mesh_terms: D000818:Animals; D001943:Breast Neoplasms; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry* / Q000254:growth & development; D013785:Thailand; D014020:Tissue Extracts / Q000737:chemistry / Q000302:isolation & purification; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D014020:Tissue Extracts; D014443:Tyrosine