Pharmacological evaluation of Shokyo and Kankyo (1).
Zingiberis Rhizoma (Shokyo, [Japanese characters: see text]) showed significant ameliorative effect on the BaCl2-induced delay of gastric emptying in rat. Bioassay-guided fractionation of the aqueous extract of Shokyo resulted in isolation of 6-gingesulfonic acid (1) and shogasulfonic acid A (3). These compounds significantly improved the delay of gastric emptying on both BaCl2-induced and N(G)-nitro-L-arginine (L-NNA)-induced model in rat. Zingiberis Siccatum Rhizoma (Kankyo, [Japanese characters: see text]) had significant efficacy against castor oil-induced diarrhea. In addition, Kankyo showed the activity increasing intestinal blood flow in normal rat.
Hashimoto
Kazunori
K
Kampo & Pharmacognosy Laboratory, Tsumura & Co., Inashiki-gun Ibaraki, Japan. hashimoto_kazunori@mail.tsumura.co.jp
Kase
Yoshio
Y
Murata
Pin
P
Kido
Toshitaka
T
Nakai
Yoichiro
Y
Sakakibara
Iwao
I
Higuchi
Masami
M
Sasaki
Hiroshi
H
Okada
Minoru
M
D000818:Animals; D003967:Diarrhea / Q000188:drug therapy / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology; D008297:Male; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D030521:Zingiberaceae / Q000737:chemistry
D010936:Plant Extracts