Necrotizing sarcoid granulomatosis presenting with elevated serum soluble interleukin-2 receptor levels.
A 52-year-old woman presented with a one-week history of low-grade fever and dyspnea. A CT scan showed multiple pulmonary nodules with cavitation, as well as bilateral pleural thickenings with effusions. A specimen resected by video-assisted thoracoscopic surgery showed multiple confluent granulomas with central necrosis and granulomatous vasculitis. These findings were consistent with necrotizing sarcoid granulomatosis. An elevated serum soluble interleukin-2 receptor level became normal following clinical and radiological improvement. This indicates that the serum soluble interleukin-2 receptor can be a useful marker for the clinical management of necrotizing sarcoid granulomatosis.
Harada
Toshiyuki
T
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan. t-harada@med.hokudai.ac.jp
Amano
Toraji
T
Takahashi
Ayumu
A
Furuya
Jungo
J
Yamaguchi
Etsuro
E
Kaji
Mitsuhito
M
Morikawa
Toshiaki
T
Itoh
Tomoo
T
Shimizu
Michio
M
Nishimura
Masaharu
M
D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D006099:Granuloma / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D015375:Receptors, Interleukin-2 / Q000097:blood*; D017565:Sarcoidosis, Pulmonary / Q000097:blood* / Q000150:complications / Q000175:diagnosis
D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2