title: Ventilator-induced lung injury: in vivo and in vitro mechanisms.
abstract: A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143-0130, USA. mmatt@itsa.ucsf.edu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Matthay
authors.forename: Sunita
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Donald
authors.initials: D
authors.lastname: Gaver
authors.forename: Lorraine B
authors.initials: LB
authors.lastname: Ware
authors.forename: Lina H K
authors.initials: LH
authors.lastname: Lim
authors.forename: Olga
authors.initials: O
authors.lastname: Syrkina
authors.forename: Fabien
authors.initials: F
authors.lastname: Eyal
authors.forename: Rolf
authors.initials: R
authors.lastname: Hubmayr
mesh_terms: D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000276:immunology / Q000503:physiopathology*; D055370:Lung Injury; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D012121:Respiration, Artificial / Q000009:adverse effects*; D013314:Stress, Mechanical