title: Toxoplasma gondii pneumonia in liver transplantation: survival after a severe case of reactivation.
abstract: Toxoplasmosis is an infrequent infection in solid organ transplantation, except in heart transplantation, where the grafting of a positive organ in a negative recipient transmits the infection in a high percentage of cases, in the absence of prophylaxis. We report a case of pneumonia by Toxoplasma gondii in a woman who received a liver transplant and had pre-transplant positive serology. Diagnosis was made by cytologic examination of bronchoalveolar lavage fluid, where the parasite was observed with hematoxylin-eosin and Giemsa staining. That finding was confirmed by direct immunofluorescence and positive polymerase chain reaction. The patient had a favorable outcome, although she had not initially received first-choice drugs. This was a case of severe illness secondary to reactivation of Toxoplasma infection, diagnosed pre-mortem and with a favorable outcome. Duration of treatment and need for secondary prophylaxis in these patients are discussed in the literature. Although infrequent, toxoplasmosis must be considered among the differential diagnoses of pulmonary infiltrates in solid organ transplantation.
authors.affiliation: Infectious Diseases Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Gascón 450, Capital Federal, Buenos Aires, Argentina. lbarcan@intramed.net.ar
authors.forename: Laura A
authors.initials: LA
authors.lastname: Barcán
authors.forename: M L
authors.initials: ML
authors.lastname: Dallurzo
authors.forename: L O
authors.initials: LO
authors.lastname: Clara
authors.forename: A
authors.initials: A
authors.lastname: Valledor
authors.forename: S
authors.initials: S
authors.lastname: Macías
authors.forename: E
authors.initials: E
authors.lastname: Zorkin
authors.forename: S
authors.initials: S
authors.lastname: Gerona
authors.forename: B
authors.initials: B
authors.lastname: Livellara
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy / Q000469:parasitology*; D012008:Recurrence; D013534:Survival; D014122:Toxoplasma / Q000302:isolation & purification / Q000502:physiology*; D014123:Toxoplasmosis / Q000188:drug therapy / Q000469:parasitology*
chemical_list: D000890:Anti-Infective Agents