Trauma-localized fixed drug eruption: involvement of burn scars, insect bites and venipuncture sites.
Little is known about why fixed drug eruption (FDE) lesions initially appear in a particular area of predilection. We describe 2 cases in whom the FDE lesions initially appeared exactly at the same sites of a previous trauma, such as burn scars and insect bites, and at a venipuncture site. The interval between the original trauma and the initial onset of FDE ranged from 2 days to 22 years. These 'trauma-localized' FDE lesions are helpful for our understanding of the mechanisms of FDE and other skin diseases, which often appear in their particular areas of predilection, a finding known as 'recall phenomenon'.
Mizukawa
Yoshiko
Y
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
Shiohara
Tetsuo
T
D000328:Adult; D002056:Burns / Q000150:complications; D002921:Cicatrix / Q000150:complications; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007299:Insect Bites and Stings / Q000150:complications; D008297:Male; D008875:Middle Aged; D018962:Phlebotomy; D012867:Skin / Q000276:immunology / Q000293:injuries* / Q000473:pathology