title: CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer.
abstract: We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The genotype frequencies did not differ significantly between cases and controls, and the genotype-specific risks were not significantly different from unity, with an odds ratio for heterozygotes compared with the common homozygote of 1.3 (95% CI 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffuse-type histopathologic subgroups.
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratories, Cambridge, United Kingdom.
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
authors.forename: Carla
authors.initials: C
authors.lastname: Oliveira
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Machado
authors.forename: Gisella
authors.initials: G
authors.lastname: Keller
authors.forename: Holger
authors.initials: H
authors.lastname: Vogelsang
authors.forename: Holger
authors.initials: H
authors.lastname: Laux
authors.forename: Karl-Friedrich
authors.initials: KF
authors.lastname: Becker
authors.forename: Heidi
authors.initials: H
authors.lastname: Hahn
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Paproski
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Brown
authors.forename: Carlos
authors.initials: C
authors.lastname: Caldas
authors.forename: David
authors.initials: D
authors.lastname: Huntsman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000235:genetics*; D002170:Canada; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011174:Portugal; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics*
chemical_list: D015820:Cadherins