title: Hypothermic and antipyretic effects of 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamides in mice.
abstract: The effect of novel pyrazolines, 3-methyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamide (MPCA) and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamide (PPCA) on body temperature and endotoxin-induced fever was investigated in mice. The subcutaneous (s.c.) administration of 1.5 mmol/kg dipyrone, MPCA or PPCA and the intracerebroventricular (i.c.v.) administration of 225 nmol dipyrone reduced basal rectal temperature. Intracerebroventricular administration of 225 nmol MPCA or PPCA did not alter basal rectal temperature. The administration of 0.15 mmol/kg (s.c.) or 25 nmol (5 microl) dipyrone (i.c.v.), MPCA or PPCA had no effect on basal rectal temperature, but reversed lipopolysaccharide-induced fever. These results suggest that MPCA and PPCA cause antipyresis, which is similar to that caused by dipyrone, and may be useful antipyretic agents.
authors.affiliation: Laboratório de Neurotoxicidade, Departamento de Química, Centro de Ciências Naturais e Exatas, Campus Universitário-Camobi, Universidade Federal de Santa Maria, Santa Maria, 97105-900, RS, Brazil.
authors.forename: Fabiane R
authors.initials: FR
authors.lastname: Souza
authors.forename: Vanessa T
authors.initials: VT
authors.lastname: Souza
authors.forename: Viviane
authors.initials: V
authors.lastname: Ratzlaff
authors.forename: Lysandro P
authors.initials: LP
authors.lastname: Borges
authors.forename: Marlí R
authors.initials: MR
authors.lastname: Oliveira
authors.forename: Helio G
authors.initials: HG
authors.lastname: Bonacorso
authors.forename: Nilo
authors.initials: N
authors.lastname: Zanatta
authors.forename: Marcos A P
authors.initials: MA
authors.lastname: Martins
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Mello
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D004177:Dipyrone / Q000737:chemistry / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy; D007035:Hypothermia / Q000139:chemically induced*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D047069:Pyrazolones
chemical_list: C430590:3-methyl-5-hydroxy-5-trichloromethyl-1H-1-pyrazolcarboxyamide; C472004:3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamide; D018712:Analgesics, Non-Narcotic; D008070:Lipopolysaccharides; D011720:Pyrazoles; D047069:Pyrazolones; C038362:pyrazolone; D004177:Dipyrone