title: Genetics and cardiac arrhythmias.
abstract: In this review, the up-to-date understanding of the molecular basis of primary ventricular arrhythmias is outlined. Two disorders have recently been well described at the molecular level, the long QT syndromes and Brugada syndrome, and we review the current scientific knowledge of each disease. Two other disorders, arrhythmogenic right ventricular dysplasia and Wolff-Parkinson-White syndrome, which are on the cusp of understanding, are also described.
authors.affiliation: Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Towbin
authors.forename: Matteo
authors.initials: M
authors.lastname: Vatta
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: N E
authors.initials: NE
authors.lastname: Bowles
mesh_terms: D001145:Arrhythmias, Cardiac / Q000235:genetics* / Q000628:therapy; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000235:genetics; D002874:Chromosome Mapping; D005808:Genes, Recessive / Q000502:physiology; D005838:Genotype; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D010641:Phenotype; D015222:Sodium Channels / Q000235:genetics / Q000502:physiology; D013398:Sudden Infant Death / Q000235:genetics; D013577:Syndrome
chemical_list: D015222:Sodium Channels