[Study of the immunological tolerance induced by peripheral intravenous infusion of donor-specific antigens].
In the experiment, donor specific tolerance was induced by DST, DSSL and DSBM through peripheral intravenous transfusion in rat cervical cardiac transplantation model. The results showed there were significant differences in graft survival time between the blank control group and the other groups (P < 0.05). The mean graft survival time days of the DST, DSSL and DSBM groups were 28.9 +/- 13.7, 42.9 +/- 6.6 and 40.3 +/- 11.6 days, respectively. The effect of component infusion was obviously better than that of DST (P < 0.05), but no statistical difference was observed between DSSL and DSBM. CsA gave a noticeable synergistic effect to the induction of immunological tolerance. MLR and CD8+ T cell were remarkably reduced(P < 0.05) in the cases of component transfusion. This study suggested that components transfusion may be of clinical use for donor-specific tolerance inducing.
Wang
J
J
Department of Urology, First Affiliated Hospital, WCUMS, Chengdu 610041.
Lu
Y
Y
Yang
Y
Y
Tang
X
X
Shen
H
H
Wang
L
L
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001803:Blood Transfusion; D006085:Graft Survival; D016027:Heart Transplantation; D007108:Immune Tolerance; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014183:Transplantation, Heterologous
D000941:Antigens