title: Effectiveness of chlorhexidine-thymol varnish for caries reduction in permanent first molars of 6-7-year-old children: 24-month clinical trial.
abstract: OBJECTIVE
  To determine the effect of chlorhexidine varnish on the prevention of caries in permanent first molars.
  
  
  METHODS
  Two groups of 6-7-year-old school children were followed up in a clinical trial, a group of 86 children whose teeth were treated with a chlorhexidine-thymol varnish (Cervitec) and a control group of 95 children. The varnish was reapplied every 3 months and the caries increments were compared at 24 months.
  
  
  RESULTS
  The DFS (decayed and filled surfaces in permanent first molars) increment in the control group (mean = 1.85; SD = 2.27) was higher than in the test group (mean = 0.95; SD = 1.38), resulting in a 48.6% caries reduction. This difference was statistically significant (P = 0.032).
  
  
  CONCLUSIONS
  Chlorhexidine-thymol varnish is effective in preventing caries in permanent first molars.
authors.affiliation: Department of Preventive Dentistry, School of Dentistry, University of Granada, Granada, Spain. pbaca@ugr.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Baca
authors.forename: M José
authors.initials: MJ
authors.lastname: Muñoz
authors.forename: Manuel
authors.initials: M
authors.lastname: Bravo
authors.forename: Pilar
authors.initials: P
authors.lastname: Junco
authors.forename: Adela P
authors.initials: AP
authors.lastname: Baca
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002648:Child; D002710:Chlorhexidine / Q000627:therapeutic use*; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007764:Lacquer; D008297:Male; D018709:Statistics, Nonparametric; D013943:Thymol / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; D002710:Chlorhexidine