title: I-type lectins.
abstract: The immunoglobulin superfamily is a large category of proteins defined by their structural similarity to immunoglobulins. The majority of these proteins are involved in protein-protein binding as receptors, antibodies or cell adhesion molecules. The I-type lectins are a subset of the immunoglobulin superfamily that are capable of carbohydrate-protein interactions. There are I-type lectins recognizing sialic acids, other sugars and glycosaminoglycans. The occurrence, structure, binding properties and (potential) biological functions of the I-type lectins are reviewed here.
authors.affiliation: Glycobiology Research and Training Center, University of California, San Diego, 9500 Gilman Drive, 0687, La Jolla CA 92093-0687, USA. tangata@ucsd.edu
authors.forename: Takashi
authors.initials: T
authors.lastname: Angata
authors.forename: Els
authors.initials: E
authors.lastname: Brinkman-Van der Linden
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism; D006001:Glycoconjugates / Q000737:chemistry / Q000378:metabolism; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D037102:Lectins / Q000145:classification / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism*; D063267:Sialic Acid Binding Ig-like Lectin 1
chemical_list: D015703:Antigens, CD; D006001:Glycoconjugates; D006025:Glycosaminoglycans; D007136:Immunoglobulins; D037102:Lectins; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C571166:SIGLEC1 protein, human; D063267:Sialic Acid Binding Ig-like Lectin 1; D019158:N-Acetylneuraminic Acid