title: [Effects of Dexamethasone, Fluorometholone and Florex on intraocular pressure after photorefractive keratectomy].
abstract: To evaluate the results of elevated intraocular pressure (IO) secondary to dropping of 0.1% Dexamethasone, Fluorometholone and Florex for 1-3 months after photorefractive keratectomy, we summed up and analysed the 3-month follow-up data on 546 eyes in three groups. The rates of IO elevated in Dexamethasone, Fluorometholone and Florex were 36%, 12.4% and 31.9% respectively. After topical use of corticosteroid, some of the elevations of IO took place as early as two weeks, but most of them occurred around 1 month. Eleven patients with IO elevation of both eyes had visual acuity decreased associated with eye-ache and halos and the other patients had no symptoms. After discontinuation of corticosteroid and institution of antiglaucoma therapy, the IO became normal in 3-7 days. In practice, this means that patients receiving corticosteroid eyedrops for more than two weeks should be checked for the possibility of ocular hypertension to prevent the corticosteroid glaucoma.
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital, WCUMS, Chengdu 610041.
authors.forename: Y
authors.initials: Y
authors.lastname: Deng
authors.forename: L
authors.initials: L
authors.lastname: Wnag
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: R
authors.initials: R
authors.lastname: Cai
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005469:Fluorometholone / Q000008:administration & dosage / Q000009:adverse effects*; D003425:Flurogestone Acetate / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D005901:Glaucoma / Q000139:chemically induced; D005938:Glucocorticoids; D006801:Humans; D007429:Intraocular Pressure; D054018:Lasers, Excimer; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D018903:Photorefractive Keratectomy; D011182:Postoperative Care
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D003907:Dexamethasone; D005469:Fluorometholone; D003425:Flurogestone Acetate