title: Inhibition of secretion of interleukin-1alpha and tumor necrosis factor alpha by the ketolide antibiotic telithromycin.
abstract: The antibiotic telithromycin was examined for its effect on secretion of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors. Secretion of each cytokine was significantly increased by LPS alone, whereas treatment with telithromycin significantly inhibited secretion of IL-1alpha and TNF-alpha but not secretion of IL-1beta, IL-6, and IL-10. Telithromycin had immunomodulatory effects as a result of alteration of secretion of IL-1alpha and TNF-alpha by monocytes.
authors.affiliation: Research Institute, Palo Alto Medical Foundation, California 94301, USA.
authors.forename: Fausto G
authors.initials: FG
authors.lastname: Araujo
authors.forename: Teri L
authors.initials: TL
authors.lastname: Slifer
authors.forename: Jack S
authors.initials: JS
authors.lastname: Remington
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D048628:Ketolides; D008070:Lipopolysaccharides / Q000494:pharmacology; D018942:Macrolides; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D007375:Interleukin-1; D048628:Ketolides; D008070:Lipopolysaccharides; D018942:Macrolides; D014409:Tumor Necrosis Factor-alpha; C106791:telithromycin