title: Cationic complex: (99m)Tc-N,N'-dimethyldiaminedithiol.
abstract: Diaminedithiol (DADT) or N-monosubstituted DADT is known to form lipophilic neutral chelates with technetium. As a result, they are used for brain imaging agents. However, 99mTc-N,N'-dimethylDADT has been demonstrated to have a positive charge and a lower lipophilicity (log P = 0.1) in this experiment. The results of a biodistribution study showed that most activity was found in the intestine after 1 hr, which is the evidence of bile excretion. Increased heart-uptake in mice suggests that this compound or its derivatives can be used as a myocardial-imaging agent.
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea. jmjng@snu.ac.kr
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Jeong
authors.forename: Yun-Sang
authors.initials: YS
authors.lastname: Lee
authors.forename: Young
authors.initials: Y
authors.lastname: Joo Kim
authors.forename: Dong
authors.initials: D
authors.lastname: Soo Lee
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
authors.forename: Myung
authors.initials: M
authors.lastname: Chul Lee
mesh_terms: D000818:Animals; D002412:Cations / Q000737:chemistry*; D002614:Chelating Agents; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013457:Sulfur Compounds; D014018:Tissue Distribution; D014915:Whole-Body Counting
chemical_list: D002412:Cations; D002614:Chelating Agents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013457:Sulfur Compounds; C471425:technetium 99m 2-methyl-1-(methyl(2-(methyl(2-methyl-2-sulfanylpropyl)amino)ethyl)amino)-2-propanethiol