title: Increased uptake of technetium-99m-hexamethylpropyleneamine oxime related to primary leptomeningeal melanoma.
abstract: We present an autopsy case of primary leptomeningeal melanoma visualized with technetium-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) single photon emission CT (SPECT) of the brain. Increased uptake of Tc-99m-HMPAO coincided with leptomeningeal enhancement on MR images and with the tumor location of the autopsy findings. It was thought that Tc-99m-HMPAO could correlate closely with melanoma. Tc-99m-HMPAO SPECT clearly showed primary leptomeningeal melanoma and severe hypoperfusion induced by intracranial hypertension and tumor proliferation.
authors.affiliation: Department of Radiology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Sagiuchi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ishii
authors.forename: Satoshi
authors.initials: S
authors.lastname: Utsuki
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Asano
authors.forename: Shinya
authors.initials: S
authors.lastname: Tsukahara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kan
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujii
authors.forename: Kazushige
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime