title: Prognosis following surgical excision of canine cutaneous mast cell tumors with histopathologically tumor-free versus nontumor-free margins: a retrospective study of 31 cases.
abstract: The purpose of this study was to determine if the presence of histopathologically tumor-free versus nontumor-free margins was prognostic for relapse or tumor-related death in dogs following surgical excision of single or multiple cutaneous mast cell tumors confined to the skin without evidence of metastasis to lymph nodes or other noncutaneous sites. Differences in tumor-related death or frequency of relapse between the two groups were not significant. Failure to achieve histopathological tumor-free margins frequently did not lead to local relapse. All tumor-related deaths occurred following local relapse. The lack of statistical support for an association between prognosis and histopathological tumor-free versus nontumor-free margins may be a result of small sample size.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Gina M
authors.initials: GM
authors.lastname: Michels
authors.forename: Deborah W
authors.initials: DW
authors.lastname: Knapp
authors.forename: Dennis B
authors.initials: DB
authors.lastname: DeNicola
authors.forename: Nita
authors.initials: N
authors.lastname: Glickman
authors.forename: Patty
authors.initials: P
authors.lastname: Bonney
mesh_terms: D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D005260:Female; D007196:Indiana / Q000453:epidemiology; D008297:Male; D012515:Mast-Cell Sarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000662:veterinary*; D011379:Prognosis; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D016019:Survival Analysis