Left ventricular remodeling subsequent to reperfused myocardial infarction: evaluation of a rat model using cardiac magnetic resonance imaging.
OBJECTIVE
This study characterized the time course of ventricular remodeling subsequent to reperfused myocardial infarction (MI) in a rat model using cardiac magnetic resonance (MR) imaging.


RESULTS
Short axis cine MR imaging was used to measure left ventricular ejection fraction (LVEF) and left ventricular volumes in Lewis rats at baseline, 1, 2, 4, 6, 8, and 10 weeks post-MI. Ventricular pressure and myocardial mass were evaluated at the 10 week time point.


RESULTS
Measurements of LVEF showed a significant decrease in cardiac function immediately after MI with no significant changes over the remainder of the time course. Measurements of left ventricular end-systolic volume (LVESV) showed significant increases over thefirst 4 weeks after MI with no significant changes over the remainder of the time course. Statistical analysis of the MR measurements of LVESV yielded a repeatability standard error of 3.3%, an inter-observer standard error of 3.3%, and an intra-observer standard error of 1.6%.


CONCLUSIONS
This study indicates that cine MRI can be used to longitudinally evaluate changes in ventricular structure and function in a rat model of left ventricular remodeling. In this animal model, preliminary results indicate that the majority of remodeling is completed by 4 weeks and no significant changes in LVEF are seen after the first week. The repeatability values indicate that cardiac MR could be used for evaluating new therapies for mitigating the effects of LV remodeling after reperfused MI.
Jones
Jeffrey R
JR
Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, USA.
Mata
Jaime F
JF
Yang
Zequan
Z
French
Brent A
BA
Oshinski
John N
JN
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004195:Disease Models, Animal; D018450:Disease Progression; D005500:Follow-Up Studies; D019028:Magnetic Resonance Imaging, Cine / Q000592:standards; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology* / Q000601:surgery*; D015425:Myocardial Reperfusion; D015588:Observer Variation; D051381:Rats; D011917:Rats, Inbred Lew; D012083:Renin / Q000378:metabolism; D015203:Reproducibility of Results; D013318:Stroke Volume / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*
D012083:Renin