[Comparative characteristic of respiratory pattern responses to kainic acid microinjections in different parts of the nucleus ambiguous].
In rats, local chemical isolation of neurones by the kainic acid helped to investigate into comparative role of different parts of the n. ambiguus in respiratory control mechanisms. We disclosed specific peculiarities of responses of rhythm and respiratory pattern to chemical isolation of different parts of the n. ambiguus. In particular, it was found that consecutive isolation of the left and right rostral parts of the n. ambiguus caused a significant decrease of the respiration rate and respiratory volume and also resulted in irreversible cessation of respiration in 83% of experiments. Isolation of symmetric medial parts of the n. ambiguus resulted in bradypnoe and a decrease of pulmonary ventilation; maximal respiratory effect was recorded after kainic acid injection in the symmetric part only, thus the irreversible cessation of respiration was recorded in 50% of experiments. After isolation of symmetric caudal parts of the n. ambiguus we observed an insignificant decrease of the respiration rate without significant changes of the respiratory volume, and number of the respiration cessation was minimal: 33%.
Iniushkin
A N
AN
State University, 443011, Samara, 1 Pavlov St., Russia.
Ivanova
Iu V
IuV
Ten'gaev
E I
EI
D000818:Animals; D005260:Female; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D051381:Rats; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology*
D007608:Kainic Acid