[Effect of jiaweiyiguanjian decoction on hypothalamus-pituitary-thyroid gland (HPT) in rat model with Yin-deficiency of liver and kidney induced by slow irritation].
OBJECTIVE
To explore the mechanism of Jiaweiyiguanjian decoction in nourishing the liver and kidney.


METHODS
A rat model with Yin-deficiency of liver and kidney was made by way of slow irritation. Thyrotropin-releasing-hormone(TRH) of thyron and blood, TSH of pituitary and blood, thyroxine, 3,5,3',5-tetraiodothyronine(FT4) and 3,3',5-traiodothyronine(FT4), 3,3',5-traiodothyronine(rT3) were used as indexes to study the effect of the decoction on HPT.


RESULTS
The TRH Secretion from hypothalamus increased (P < 0.05), TSH of pituitary and blood reduced(P < 0.05), FT3 and FT4 of blood decreased at the same time and rT3 of blood, increased. The indexes of the treatment group were found almost the same as the those of the normal control group.


CONCLUSIONS
Jiaweiyiguanjian Decoction could adjust HPT.
Ren
X Q
XQ
Henan College of Traditional Chinese Medicine, Zhengzhou 450003, Henan, China.
Lu
Y Q
YQ
Deng
W
W
Li
H L
HL
Chu
Y C
YC
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D010946:Plants, Medicinal; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism; D016710:Yin Deficiency / Q000378:metabolism*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine