Translating axon guidance cues.
Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery that would allow the local synthesis of receptors for axon guidance cues.
Steward
Oswald
O
Reeve-Irvine Research Center, Department of Anatomy and Neurobiology, Department of Neurobiology and Behavior, University of California, Irvine Irvine, CA 92697, USA. osteward@uci.edu
D000818:Animals; D001369:Axons / Q000378:metabolism*; D020439:Growth Cones / Q000502:physiology*; D008565:Membrane Proteins / Q000096:biosynthesis; D014176:Protein Biosynthesis; D015398:Signal Transduction
D008565:Membrane Proteins