title: Haemodialysis for the prevention of contrast-induced nephropathy: outcome of 31 patients with severely impaired renal function, comparison with patients at similar risk and review.
abstract: OBJECTIVE
  To investigate whether haemodialysis prevents contrast-induced nephropathy (definition: increase of serum-creatinine of >or= 0.5 mg/dL within 7 days).
  
  
  METHODS
  Thirty-one patients (mean serum-creatinine 4.01 +/- 1.83 mg/dL) were dialyzed for 4.36 +/- 1.0 hours within one hour after 278.4 +/- 160.5 mL of contrast medium.
  
  
  RESULTS
  Dialysis resulted in a significant reduction of serum-creatinine (2.25 +/- 1.46 mg/dL; P< 0.0001) and stable mean serum-creatinine levels 2, 3, 4, and 7 days after contrast medium and at discharge compared with baseline values. However, 19 patients (61%) developed contrast-induced nephropathy within 7 days. Four patients had to be repeatedly dialyzed. A comparison of our patients' 48 hours-incidence of contrast-induced nephropathy (9/31; 29%) versus patients at comparable risk included in seven previous studies demonstrated a prophylactic effect of dialysis only versus a subgroup in one study.
  
  
  CONCLUSIONS
  Data provide no hint that haemodialysis prevents contrast-induced nephropathy. Therefore, postprocedural dialysis should be restricted to patients participating in clinical studies.
authors.affiliation: Department of Internal Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Germany. Wolfgang.Huber@t-online.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Huber
authors.forename: Barbara
authors.initials: B
authors.lastname: Jeschke
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kreymann
authors.forename: Michael
authors.initials: M
authors.lastname: Hennig
authors.forename: Michael
authors.initials: M
authors.lastname: Page
authors.forename: Hermann
authors.initials: H
authors.lastname: Salmhofer
authors.forename: Florian
authors.initials: F
authors.lastname: Eckel
authors.forename: Ulrike
authors.initials: U
authors.lastname: Schmidt
authors.forename: Andreas
authors.initials: A
authors.lastname: Umgelter
authors.forename: Ursula
authors.initials: U
authors.lastname: Schweigart
authors.forename: Meinhard
authors.initials: M
authors.lastname: Classen
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology* / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D006801:Humans; D007677:Kidney Function Tests; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D003404:Creatinine