A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study.
Winiarczyk
Stanislaw
S
Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, Agriculture University, Gleboka Street 30, 20612 Lublin, Poland.
Gradski
Zbigniew
Z
Kosztolich
Barbara
B
Gabler
Cornelia
C
König
Gerhardt
G
Renner
Matthias
M
Saller
Robert M
RM
Prosl
Heinrich
H
Salmons
Brian
B
Günzburg
Walter H
WH
Hain
Johannes
J
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002214:Capsules; D017690:Cell Transplantation; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019362:Cytochrome P-450 CYP2B1 / Q000235:genetics* / Q000378:metabolism; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007267:Injections; D015674:Mammary Neoplasms, Animal / Q000628:therapy*; D010865:Pilot Projects; D011355:Prodrugs / Q000627:therapeutic use*; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
D018906:Antineoplastic Agents, Alkylating; D002214:Capsules; D011355:Prodrugs; D003520:Cyclophosphamide; D019362:Cytochrome P-450 CYP2B1