title: [Genomics of pathogenic bacteria].
abstract: The general principles of structural and functional organization of genomes in pathogenic bacteria are considered. Main data on the specific features of genomes of Chlamydia trachomatis, Rickettsia prowazekii, Treponema pallidum, Helicobacter pylori, Haemophilus influenzae, Neisseria meningitidis, Vibro cholerae and pathogenic strains of Escherichia coli are summarized. Particular attention is paid to the problems of genetic control of pathogenicity, intraspecies variations in bacterial genomes, to the environmental and evolutionary meaning of horizontal gene transfer. Whether methods for genotyping bacterial strains can be used is discussed.
authors.forename: S V
authors.initials: SV
authors.lastname: Shestakov
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D022761:Gene Transfer, Horizontal; D016680:Genome, Bacterial; D005838:Genotype