Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp.
Four new indoles, ancorinolates A-C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3,2-a]carbazole described as a natural product. Ancorinolates A (1) and C (3) showed weak HIV-inhibitory activity in the XTT-based, anticytopathicity assay.
Meragelman
Karina M
KM
Molecular Targets Drug Discovery Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
West
Lyndon M
LM
Northcote
Peter T
PT
Pannell
Lewis K
LK
McKee
Tawnya C
TC
Boyd
Michael R
MR
D000107:Acetylation; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013058:Mass Spectrometry; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
D019380:Anti-HIV Agents; D007211:Indoles; C472806:ancorinolate A; C472805:ancorinolate C; C472804:bis-ancorinolate B