title: Blood substitutes and oxygen therapeutics: an overview and current status.
abstract: This review article discusses the development and implementation of a number of blood substitutes, including hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbons. This review article will introduce the reader to blood substitutes by discussing an overview of an ideal blood substitute, the history of HBOCs and perfluorocarbons, strategies of oxygen carrying, side effects of HBOCs and perfluorocarbons, current clinical trials, and the future of blood substitutes.
authors.affiliation: Department of Anesthesiology, University of California at Los Angeles, Los Angeles, CA 90095-1778, USA. jsjahr@mednet.ucla.edu
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Jahr
authors.forename: Susmita B
authors.initials: SB
authors.lastname: Nesargi
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lewis
authors.forename: Calvin
authors.initials: C
authors.lastname: Johnson
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005466:Fluorocarbons / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans
chemical_list: D001802:Blood Substitutes; D005466:Fluorocarbons