Effect of biogenic amines on oxidation of farmorubicin by Fenton-like reagents.
The aim of this study was to investigate the effect of dopa and catecholamines on the generation of oxygen active species during oxidation of farmorubicin by "Fenton-like" reagents using chemiluminescent and spectrophotometric techniques. The tested catechols were found to reduce the light emission accompanying oxidation of farmorubicin by Co(II) + H2O2 and Cu(II) + H2O2 mixtures. The quenching effect was followed by their rapid oxidation to aminochromes possessing toxic activities.
Kruk
Irena
I
Institute of Physics, Technical University of Szczecin, Szczecin, Poland.
Lichszteld
Krzysztof
K
Aboul-Enein
Hassan Y
HY
D001679:Biogenic Amines; D002395:Catecholamines; D003035:Cobalt; D003300:Copper; D004295:Dihydroxyphenylalanine; D015251:Epirubicin / Q000737:chemistry*; D006861:Hydrogen Peroxide; D007501:Iron; D008163:Luminescent Measurements; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species; D013053:Spectrophotometry / Q000379:methods
D001679:Biogenic Amines; D002395:Catecholamines; C045076:Fenton's reagent; D017382:Reactive Oxygen Species; D003035:Cobalt; D015251:Epirubicin; D004295:Dihydroxyphenylalanine; D003300:Copper; D006861:Hydrogen Peroxide; D007501:Iron