Adult Henoch-Schönlein purpura with glomerulonephritis and paroxysmal nocturnal haemoglobinuria: an uncommon association.
Henoch-Schönlein purpura (HSP) is considered to be a small blood vessel systemic vasculitis. Numerous microorganisms have been implicated in triggering HSP. We describe an unusual case of HSP with glomerulonephritis and renal failure requiring haemodialysis in a young adult man who subsequently developed paroxysmal nocturnal haemoglobinuria (PNH) with several haemolytic episodes. Bacterial infections, especially those of the respiratory and urinary tract, might trigger both the diseases.
Cozzi
F
F
University of Padua, Padua, Italy. franco.cozzi@unipd.it
Botsios
C
C
Ostuni
P
P
Sfriso
P
P
Piva
E
E
Marson
P
P
Punzi
L
L
Todesco
S
S
D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000328:Adult; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D017707:Erythrocyte Transfusion; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D018570:Risk Assessment; D016896:Treatment Outcome