Gene expression analysis in burn wounds of rats.
The events occurring early in the burn wound trigger a sequence of local and systemic responses that influence cell and tissue survival and, consequently, wound healing and recovery. Using high-density oligonucleotide arrays we identified gene expression patterns in skin samples taken from a region of injury in the burn rat model. The associated genomic events include the differential expression of genes involved in cell survival and death, cell growth regulation, cell metabolism, inflammation, and immune response. The functional gene cluster detected and their time appearance matched the time sequence known to occur in burn wound healing.
Spies
Marcus
M
Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston 77550, USA.
Dasu
Mohan R K
MR
Svrakic
Nenad
N
Nesic
Olivera
O
Barrow
Robert E
RE
Perez-Polo
J Regino
JR
Herndon
David N
DN
D000818:Animals; D000917:Antibody Formation; D002056:Burns / Q000235:genetics*; D002455:Cell Division / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D003872:Dermatitis / Q000235:genetics; D015870:Gene Expression; D020869:Gene Expression Profiling; D016678:Genome; D008297:Male; D005810:Multigene Family / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000276:immunology / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors