title: [Quantitative assessment of neuromuscular block of the orbicularis oculi muscle].
abstract: In a prospective clinical study neuromuscular block at the orbicular ocular muscle was examined qualitatively and quantitatively by an AMG approach. The signals were recorded, visualized and evaluated simultaneously under PC-support after TOF-stimulation in 20 s intervals. Fifty ASA I and II patients were included into the study. After oral premedication with midazolam 10-15 mg, anaesthesia was induced with propofol 2 mg/kg and alfentanil 0.02 mg/kg and maintained by means of propofol 6-8 mg/kg/h and alfentanil 0.02 mg/kg/h. After intubation and signal stabilization, mivacurium 0.75 mg/kg was administered and neuromuscular blockade was recorded online. The measured acceleration at the orbicular ocular muscle amounted 0.9 g on average. Maximal neuromuscular block was registered at 78.5% and the TOF-ratio of 0.8 was achieved after 14.1 min. The low values of the AMG-signals of the orbicular ocular muscle requiring very high technical demands on the measuring instrument. Additional problems arise through the considerable temporal expenditure for discovering the optimal location of stimulation. During the AMG monitoring the position dependence of the measured values of the sensors must be taken into consideration. These technical problems restrict the suitability of the AMG at the orbicular ocular muscle as a quantitative neuromuscular monitoring tool.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universität Rostock.
authors.forename: R
authors.initials: R
authors.lastname: Hofmockel
authors.forename: B
authors.initials: B
authors.lastname: Pohl
authors.forename: R
authors.initials: R
authors.lastname: Brahmstaedt
authors.forename: G
authors.initials: G
authors.lastname: Nöldge-Schomburg
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001767:Blinking / Q000187:drug effects*; D004576:Electromyography / Q000295:instrumentation*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D000077590:Mivacurium; D016343:Monitoring, Intraoperative / Q000295:instrumentation*; D009469:Neuromuscular Junction / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D009862:Online Systems / Q000295:instrumentation; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
chemical_list: D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium