title: Effects of non-uniform static magnetic fields on the rate of myosin phosphorylation.
abstract: The effect on myosin phosphorylation from exposure to a magnetic field generated by an array of four permanent magnets was investigated. Two lateral positions in the non-uniform field over the array were explored, each at four vertical distances over the surface of the device. The rate of myosin phosphorylation was found to depend on the position laterally over the array as well as the distance from the device surface. The square magnet array was comprised of axially magnetized, cylindrical NdFeB permanent magnets arranged with poles of alternating polarity in a plane (MagnaBloc trade mark therapeutic device). Detailed dosimetry of the magnet array was compiled: the magnetic flux density averaged over the exposure volume spanned the range 0.7-86 mT for the eight different exposure positions. The corresponding range for the absolute field gradient was 0.4-20 T/m. Comparing the dosimetry to the experimental outcome, our results imply that magnetic field amplitude alone is not sufficient to describe the influence of the field in this preparation.
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville Tennessee 37232-3375, USA. stefan.engstrom@mcmail.vanderbilt. edu
authors.forename: Stefan
authors.initials: S
authors.lastname: Engström
authors.forename: Marko S
authors.initials: MS
authors.lastname: Markov
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McLean
authors.forename: Robert R
authors.initials: RR
authors.lastname: Holcomb
authors.forename: Julia M
authors.initials: JM
authors.lastname: Markov
mesh_terms: D000818:Animals; D001703:Biophysics / Q000295:instrumentation; D066298:In Vitro Techniques; D008280:Magnetics / Q000627:therapeutic use*; D008954:Models, Biological; D018994:Myosin Light Chains / Q000378:metabolism; D009218:Myosins / Q000378:metabolism*; D010766:Phosphorylation; D014422:Turkeys
chemical_list: D018994:Myosin Light Chains; D009218:Myosins