[Effect of propofol and midazolam on cerebral oxygen supply and demand imbalance during cardiopulmonary bypass].
Thirty patients undergoing heart valve replacement were divided randomly into three groups (n = 10): control group, propofol group and midazolam group. Jugular bulb blood oxygen saturation (SjO2), arterialvenous oxygen content difference (Da-vO2) and cerebral oxygen extraction rate(CEO2) were measured at various periods of cardiopulmonary bypass (CPB). The results showed: SjO2 decreased significantly, Da-vO2 and CEO2 increased markedly during rewarming period in control group; but in propofol group and midazolam group, SjO2, CEO2 and Da-vO2 did not decline significantly compared with baseline. It is suggested that administering propofol or midazolam is helpful in avoiding cerebral oxygen supply and demand imbalance during CPB.
Chen
A W
AW
Department of Anesthesiology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Li
L
L
Chang
Y T
YT
D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology
D018686:Anesthetics, Intravenous; D008874:Midazolam; D015742:Propofol