title: Screening of South American plants against human immunodeficiency virus: preliminary fractionation of aqueous extract from Baccharis trinervis.
abstract: Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.
authors.affiliation: Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Sanchez Palomino
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Abad
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Bedoya
authors.forename: Javier
authors.initials: J
authors.lastname: García
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gonzales
authors.forename: Ximena
authors.initials: X
authors.lastname: Chiriboga
authors.forename: Paulina
authors.initials: P
authors.lastname: Bermejo
authors.forename: José
authors.initials: J
authors.lastname: Alcami
mesh_terms: D031175:Baccharis; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D013020:South America
chemical_list: D010936:Plant Extracts