title: Application of Molecular Adsorbent Recirculating System in patients with severe liver failure after hepatic resection or transplantation: initial single-centre experiences.
abstract: Acute liver failure after hepatic surgery is still plaqued with high mortality rate. Recently, a liver dialysis system (MARS) that allows detoxification of albumin-bound substances and may hereby support liver regeneration and patient's recovery has been developed. In the present study, we report our experiences with MARS dialysis in patients with liver failure after hepatic resection or transplantation. Between September 1999 and January 2001, five patients were treated with MARS (2-5 courses). Though beneficial effects such as improvement of encephalopathy and renal function as well as reduced bilirubin levels were recorded during MARS therapy, only one patient survived. Neither significant technical problems nor adverse effects occurred by using MARS dialysis. We conclude that in surgical patients, acute liver failure is usually part of a complicated clinical course affecting multipleorgan systems. Thus, it is difficult to determine the specific influence of MARS on patient's outcome. However, beneficial effects observed in our patients justify its continuous use and may stimulate further evaluation in controlled studies with surgical patients.
authors.affiliation: Department of Surgery, University of Würzburg, Germany. rkellers@mail.uni-wuerzburg.de
authors.forename: Richard
authors.initials: R
authors.lastname: Kellersmann
authors.forename: Heinz-Jochen
authors.initials: HJ
authors.lastname: Gassel
authors.forename: Christoph
authors.initials: C
authors.lastname: Bühler
authors.forename: Arnulf
authors.initials: A
authors.lastname: Thiede
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Timmermann
mesh_terms: D006498:Hepatectomy; D006801:Humans; D017114:Liver Failure, Acute / Q000601:surgery* / Q000628:therapy*; D016031:Liver Transplantation; D011183:Postoperative Complications / Q000628:therapy; D006435:Renal Dialysis; D012720:Severity of Illness Index; D016060:Sorption Detoxification; D016896:Treatment Outcome