Lipid rafts and assembly of enveloped viruses.
The plasma membrane, late secretory pathway and endosomal compartments contain detergent-insoluble raft microdomains that are enriched in sphingolipids and cholesterol. Rafts are currently an intensively studied topic of cell biology, and raft involvement has been implicated in numerous cellular processes. A number of recent reports have localized structural proteins of several enveloped viruses to rafts, thus raising the possibility that rafts also play a role in the assembly and budding of viruses, but what exactly that role might be is still unknown.
Suomalainen
Maarit
M
Department of Biosciences at Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden. maarit.suomalainen@cbt.ki.se
D050356:Lipid Metabolism; D008055:Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D019065:Virus Assembly; D018406:Virus Physiological Phenomena
D008055:Lipids; D008565:Membrane Proteins