An attempt at evaluating borderline conditions of Parkinson's disease and its preclinical stage on the basis of clinical and morphological correlation.
The aim of the investigations was to find to what extent neurodegenerative changes develop in the brains of patients with no clinical symptoms of dementia, parkinsonism and other neurodegenerative diseases. It has been found that neurodegenerative pathology, as evaluated using immunohistochemical methods with monoclonal antibodies (Mab) against ubiquitin, tau protein, alpha-synuclein, and beta-amyloid, occurs more frequently than the presence of Lewy bodies. The degenerative changes involved the neurones of cerebral and cerebellar cortex, basal ganglia and medulla oblongata, where neurofibrillary tangles were found. Mab positive materials have been found in the cytoplasm of the cell body and the cell processes (axons) of the neurones and glial cells. Senile plaques, beta-amyloid positive, were frequently noted.
Krygowska-Wajs
Anna
A
Department of Neurology and Neuropathology, Collegium Medicum, Jagiellonian University, Kraków, Poland. krygowska@neuro.cm-uj.krakow.pl
Adamek
Dariusz
D
Szczudlik
Andrzej
A
Kałuza
Józef
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001923:Brain Chemistry / Q000502:physiology; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology* / Q000503:physiopathology