[Potential gastroprotective effect of a CysLT1 receptor blocker sodium montelukast in aspirin-induced lesions of the rat stomach mucosa].
Montelukast sodium, a specific leukotriene receptor (CysLT1) blocker administered orally in a dose of 40 mg/kg prevented the stomach mucosa in rats from acute erosive gastritis model induced by acetylsalicylic acid (150 mg/kg, p.o.) in male albino Wistar rats. The potential role of a "5-lipooxygenase shunting" of the arachidonic acid metabolism in the gastrointestinal toxicity of non-selective cyclooxygenase inhibitors is discussed.
Marusova
I B
IB
Valdman Institute of Pharmacology, Pavlov State Medical University, ul. L. Tolstogo 6/8, St. Petersburg, 197022 Russia.
Vlasov
T D
TD
Marusov
I V
IV
Panchenko
A V
AV
D000085:Acetates; D000208:Acute Disease; D000818:Animals; D001241:Aspirin; D003521:Cyclopropanes; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D017998:Leukotriene D4 / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins; D011804:Quinolines; D051381:Rats; D017208:Rats, Wistar; D018077:Receptors, Leukotriene; D013440:Sulfides
D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D008565:Membrane Proteins; D011804:Quinolines; D018077:Receptors, Leukotriene; D013440:Sulfides; D017998:Leukotriene D4; C412375:cysteinyl leukotriene receptor 2; C083169:leukotriene D4 receptor; C093875:montelukast; D001241:Aspirin