Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation.
The radioprotective effect of the root extract of Glycyrrhiza glabra L on lipid peroxidation in rat liver microsomes and plasmid pBR322 DNA was investigated. The extract was found to protect microsomal membranes, as evident from reduction in lipid peroxidation, and could also protect plasmid DNA from radiation-induced strand breaks.
Shetty
T K
TK
Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Satav
J G
JG
Nair
C K K
CK
D000818:Animals; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D006035:Glycyrrhiza; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D008861:Microsomes / Q000187:drug effects* / Q000528:radiation effects; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010957:Plasmids / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts