title: Production and characterization of biodegradable Povidone-iodine microsphere as a intramammary disinfectant.
abstract: Microspheres composed of biocompatible, biodegradable poly DL-lactide-co-glycolide (DL-PLGA) and Povidone-iodine were evaluated as an intramammary disinfectant delivery system in vitro prior to infusion into mammary glands. Microsphere was prepared by solvent evaporation method and particle size, morphology and in vitro release kinetics were examined. The microspheres were ranged in size from 25 microm to 155 microm (mean diameter = 65.7 microm). Povidone-iodine was dispersed on the surface of microsphere and microsphere was spherical in shape with a smooth surface. The yield of microsphere was 57.3% and the encapsulation efficiency was 69.6%. In in vitro release study, a burst effect (50.9%) was observed during the first two days and a sustained release then continued for the next 28 days. Results of the present study demonstrated that microsphere have the potential for new intramammary disinfectant formulations that can provide increased efficacy of therapy against mastitis pathogens.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
authors.forename: Hong-Ryul
authors.initials: HR
authors.lastname: Han
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002417:Cattle; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005260:Female; D066298:In Vitro Techniques; D008414:Mastitis, Bovine / Q000517:prevention & control*; D008863:Microspheres; D010316:Particle Size; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011206:Povidone-Iodine