title: Decrease of specific and total IgE levels in allergic patients after BCG vaccination: preliminary report.
abstract: BACKGROUND
  A systemic reaction to mycobacteria biases the balance of T helper cell types 1 and 2 toward T helper cell type 1. BCG vaccination mimics some characteristics of mycobacterial infection. Children who have undergone tuberculin conversion after BCG vaccination seem to be more likely to lose their atopic symptoms. Inhibition of both allergic response and airway hyperreactivity after vaccination for mycobacteria has been observed in animal experiments.
  
  
  OBJECTIVE
  To evaluate the effects that BCG vaccination has on the serological status of allergic people.
  
  
  METHODS
  This study included 20 volunteers with a history of allergic rhinitis who were required to undergo BCG vaccination by Italian law. Epicutaneous allergy testing with a panel of common seasonal and perennial inhalational allergens and 2 blood withdrawals were performed. The serum total IgE levels and the serum allergen-specific IgE levels of each individual were measured just before BCG vaccination and again 4 months later. Total IgE levels were determined using the paper radioimmunosorbent test, and allergen-specific IgE levels were determined using the radioallergosorbent test.
  
  
  RESULTS
  Total IgE and allergen-specific IgE levels were significantly decreased after BCG vaccination (P =.004 and P<.001, respectively).
  
  
  CONCLUSIONS
  BCG, an effective stimulus for cell-mediated immunity, deserves further study to evaluate its ability to modulate the immune response associated with allergic rhinitis.
authors.affiliation: Dipartimento di Fisiopatologia Clinica, I Clinica Otorinolaringoiatrica, University of Turin, Via Genova No. 3, 10126 Turin, Italy. mt.eli@virgilio.it
authors.forename: Giovanni P
authors.initials: GP
authors.lastname: Cavallo
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Elia
authors.forename: Daniela
authors.initials: D
authors.lastname: Giordano
authors.forename: Cristina
authors.initials: C
authors.lastname: Baldi
authors.forename: Raffaella
authors.initials: R
authors.lastname: Cammarota
mesh_terms: D000328:Adult; D001500:BCG Vaccine / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000187:drug effects* / Q000276:immunology; D008297:Male; D011852:Radioallergosorbent Test; D011864:Radioimmunosorbent Test; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood* / Q000276:immunology; D013997:Time Factors
chemical_list: D001500:BCG Vaccine; D007073:Immunoglobulin E