title: Histological examination of beta-tricalcium phosphate graft in human femur.
abstract: Prominent osteoconductive activity and the biodegradable nature of beta tricalcium phosphate (beta-TCP) for bone grafts in animal experiments has been reported. A new type of beta-TCP has been manufactured at extraordinarily high purity and has been available as potent bone grafting substitute for clinical use. The histological features of grafted beta-TCP in human bone have been analyzed. A 33-year-old female with a bone tumor of the proximal femur underwent curettage and beta-TCP graft under the diagnosis of probable benign fibrous dysplasia. Four weeks later, the proximal femur, including the grafted beta-TCP was resected because of the final diagnosis of the curettaged materials was osteosarcoma. The resected specimen revealed abundant direct new bone apposition on beta-TCP. There was no cartilaginous tissue or enchondral ossification. Bone formation was more prominent in the periphery of the grafted area than in the center. There was a considerable number of osteoclast-like giant cells surrounding the beta-TCP. This case illustrated that highly purified beta-TCP had prominent osteoconductive activity and biodegradable nature in human bone.
authors.affiliation: Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan. aogose@med.niigata-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Ogose
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hotta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hatano
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawashima
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Naoto
authors.initials: N
authors.lastname: Endo
authors.forename: Hajime
authors.initials: H
authors.lastname: Umezu
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery; D005269:Femur / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D016348:Osseointegration / Q000502:physiology; D012516:Osteosarcoma / Q000601:surgery; D019736:Prostheses and Implants; D011859:Radiography
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; C018392:tricalcium phosphate