Acute megakaryocytic leukemia presenting as hypercalcemia with skeletal lytic lesions.
Acute megakaryocytic leukemia (AML M7) is a rare type of acute myelogenous leukemia in adults, commonly presenting with myelofibrosis. This report describes a case of a 32-yr-old male who presented with hypercalcemia and bony lytic lesions, in the absence of myelofibrosis. The diagnosis of AML M7 should be considered in a patient with pancytopenia, lytic lesions and hypercalcemia.
Muler
Jeffrey H
JH
Division of Hematology/Oncology, University of Michigan Cancer Center, Room 4316, 1500E Medical Center Drive, Ann Arbor, MI 48109, USA.
Valdez
Riccardo
R
Hayes
Curtis
C
Kaminski
Mark S
MS
D000063:Accidents, Traffic; D000328:Adult; D001706:Biopsy; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D006934:Hypercalcemia / Q000000981:diagnostic imaging / Q000209:etiology*; D007947:Leukemia, Megakaryoblastic, Acute / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D014057:Tomography, X-Ray Computed