Preferential involvement of larger vessels in a rat model of diabetes-induced graft vasculopathy.
Using previously described models of diabetes-induced transplant coronary artery atherosclerosis (TxCAD), we quantitatively assessed TxCAD using computer-assisted morphometric measurements. More than 95% of the evaluated vessels were intramyocardial vessels. The first and last tertile of the vessel size distribution were evaluated for the presence of TxCAD. Severe TxCAD, defined as a luminal occlusion > or =75%, was more prevalent in the larger vessels. We observed a differential involvement based on vessel size in diabetes-induced TxCAD.
Cantin
Bernard
B
Division of Cardiovascular Medicine, Stanford University School of Medicine, California, USA.
Zhu
Dening
D
Wen
Peizhong
P
Panchal
Shyam N
SN
Gwathmey
Judith K
JK
Reaven
Gerald M
GM
Valantine
Hannah A
HA
D000818:Animals; D003324:Coronary Artery Disease / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000473:pathology*; D006083:Graft Occlusion, Vascular / Q000473:pathology*; D016027:Heart Transplantation / Q000009:adverse effects; D023421:Models, Animal; D051381:Rats; D013311:Streptozocin
D013311:Streptozocin