title: Synthesis of new molecules containing head, spacer, and label moieties.
abstract: We describe the synthesis and characterization of novel molecules containing head with precise shape, spacer, and label moieties. The protocol is based on a Pd(0)-catalyzed cross-coupling reaction between ethynylphenyl/bromide to obtain a rigid head followed by the attachment of a flexible spacer possessing two reactive functional groups on the termini. The final step consists of forming a covalent bond between spacer and label. In addition, monosubstituted soluble labels were synthesized in good yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland.
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Khatyr
authors.forename: Huub
authors.initials: H
authors.lastname: Maas
authors.forename: Gion
authors.initials: G
authors.lastname: Calzaferri