title: Incidence of iris colour change in latanoprost treated eyes.
abstract: OBJECTIVE
  To determine the incidence of increased iris pigmentation in eyes treated with chronic latanoprost. This is an observational, cohort study.
  
  
  METHODS
  The anterior segments of both eyes of 43 patients with glaucoma were photographed after unilateral latanoprost therapy. Two independent, masked observers analysed the slides of both eyes of the study participants, and compared the iris pigmentation of both eyes of each patient using a stereo viewer.
  
  
  RESULTS
  30 patients (69.7%) had a definite acquired iridial anisochromia; 15 patients (50%) had increased superficial iris pigmentation with a "granular" appearance (type 1 change), and 15 patients (50%) had an increased "stromal pigmentation"-that is, the affected iris appeared darker than the fellow eye, but without a "granular" appearance (type 2 change).
  
  
  CONCLUSIONS
  The incidence of increased iris pigmentation induced by latanoprost is much higher than previously reported. The high prevalence of mixed iris colour found in this population and the fact that the patients studied were undergoing unilateral therapy may explain these results.
authors.affiliation: Department of Ophthalmology, Príncipe de Asturias Hospital, University of Alcalá, Alcalá de Henares, Madrid, Spain. mteus@teleline.es
authors.forename: M A
authors.initials: MA
authors.lastname: Teus
authors.forename: E
authors.initials: E
authors.lastname: Arranz-Márquez
authors.forename: P
authors.initials: P
authors.lastname: Lucea-Suescun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology; D005127:Eye Color / Q000187:drug effects*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007498:Iris / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D010781:Photography; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost