title: [Is p53 immunohistochemistry useful for optimal decision for treatment of polypoid lesions in ulcerative colitis?].
abstract: BACKGROUND
  Usefulness of p53 staining for the differentiation between adenoma and DALM has been reported recently, so recognizable lesions stained positively can be diagnosed as DALMs. For the cases with DALMs, total colectomy has been thought to be necessary.
  
  
  METHODS
  Immunohistochemical staining for p53 was performed in 4 adenocarcinomas and 4 adenomas in ulcerative colitis.
  
  
  RESULTS
  Three carcinomas and 3 adenomas were positive. One carcinoma (protruded mucosal cancer) and 3 adenomas (1 flat elevated lesion and 2 laterally spreading tumors) stained positively for p53 were treated only by polypectomy or local excision. The patients have been under surveillance for periods ranging from 1 to 10 years, during which no metachronous dysplasia has developed.
  
  
  CONCLUSIONS
  These findings suggest that some groups of the polypoid lesions can be resected locally even if stained positively by p53 immunohistochemistry.
authors.affiliation: Department of Gastroenterology, Toyohashi Municipal Hospital.
authors.forename: Taku
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Shozo
authors.initials: S
authors.lastname: Okamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohashi
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Urano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kanamori
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hosoi
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Kako
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kurahashi
authors.forename: Kose
authors.initials: K
authors.lastname: Segawa
authors.forename: Matsuyoshi
authors.initials: M
authors.lastname: Maeda
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003111:Colonic Polyps / Q000209:etiology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D016159:Tumor Suppressor Protein p53