title: Comparative study of tissue response to polyglecaprone 25, polyglactin 910 and polytetrafluorethylene suture materials in rats.
abstract: The authors evaluated the biocompatibility of three suture materials, polyglecaprone 25, polyglactin 910 and polytetrafluorethylene, implanted into subcutaneous tissue in the dorsal region of 20 Wistar albinus rats. After periods of 2, 7, 14 and 21 days, the rats were sacrificed and the specimens were processed for routine histotechnical analysis and stained with hematoxylin and eosin. The rate of fibrosis, angioblastic and fibroblastic proliferation, and also the intensity of inflammation were observed with the optic microscope. The results showed that polyglecaprone 25 suture material induced a mild inflammatory reaction, followed by polyglactin 910 and polytetrafluorethylene, respectively. Such biological behavior must be considered during the selection of the suture material to be used in oral surgery.
authors.affiliation: Department of Oral Surgery, School of Dentistry, Sacred Heart University (USC), Bauru, SP, Brazil. iocp@uol.com.br
authors.forename: Hugo
authors.initials: H
authors.lastname: Nary Filho
authors.forename: Mariza Akemi
authors.initials: MA
authors.lastname: Matsumoto
authors.forename: Aline Carvalho
authors.initials: AC
authors.lastname: Batista
authors.forename: Luís Cesar
authors.initials: LC
authors.lastname: Lopes
authors.forename: Fernanda Costa Grizzo Sampaio
authors.initials: FC
authors.lastname: de Góes
authors.forename: Alberto
authors.initials: A
authors.lastname: Consolaro
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002455:Cell Division; D004396:Coloring Agents; D003238:Connective Tissue / Q000473:pathology; D004146:Dioxanes / Q000737:chemistry*; D004801:Eosine Yellowish-(YS); D005347:Fibroblasts / Q000473:pathology; D005355:Fibrosis; D005456:Fluorescent Dyes; D015726:Giant Cells / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology; D006416:Hematoxylin; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D009389:Neovascularization, Pathologic / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D011091:Polyesters / Q000737:chemistry*; D011098:Polyglactin 910 / Q000737:chemistry*; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology; D013223:Statistics as Topic; D013537:Sutures; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D004396:Coloring Agents; D004146:Dioxanes; D005456:Fluorescent Dyes; D011091:Polyesters; D011098:Polyglactin 910; C095495:glycolide E-caprolactone copolymer; D011138:Polytetrafluoroethylene; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin