title: [Risk factors in adult periodontitis: polymorphism in the interleukin-1 gene family].
abstract: Interleukin (IL)-1 alpha, IL-1 beta and IL-1 receptor antagonist (ra) play a major role in regulation of the inflammatory response in periodontal tissues. The aim of this study was to investigate the distribution of genetic variation in the IL-1 gene family among periodontitis patients and controls, taking into account smoking and microbiology as additional variables. There were 53 non-smoking and 52 smoking patients with severe adult periodontitis and 53 periodontal healthy controls genotyped for genetic variation in the IL-1 gene family. The presence of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans was established by culture techniques. A higher frequency of genotype+ (IL-1A*2 + IL-1B*2 + IL-1RN*2) was found in non-smoking periodontitis patients in whom P. gingivalis and A. actinomycetemcomitans could not be detected (42.1% vs. 11.3% in controls; p = 0.0068; or 5.7, 95% ci: 1.6-19.8). This data provide evidence that polymorphisms in genes of the IL-1 family are associated with severe adult periodontitis and may be a risk factor for severe periodontitis.
authors.affiliation: Sectie Klinische Orale Microbiologie, Academisch Centrum voor Tandheelkunde Amsterdam (ACTA), Van der Boechorststraat 7, 1081 BT Amsterdam. ml.laine.omb.acta@med.vu.nl
authors.forename: M L
authors.initials: ML
authors.lastname: Laine
authors.forename: M A
authors.initials: MA
authors.lastname: Farré
authors.forename: M A
authors.initials: MA
authors.lastname: García-González
authors.forename: L J
authors.initials: LJ
authors.lastname: van Dijk
authors.forename: A J
authors.initials: AJ
authors.lastname: Ham
authors.forename: E G
authors.initials: EG
authors.lastname: Winkel
authors.forename: J B A
authors.initials: JB
authors.lastname: Crusius
authors.forename: J P
authors.initials: JP
authors.lastname: Vandenbroucke
authors.forename: A J
authors.initials: AJ
authors.lastname: van Winkelhoff
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000472:pathogenicity / Q000502:physiology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics* / Q000382:microbiology; D011110:Polymorphism, Genetic; D016966:Porphyromonas gingivalis / Q000472:pathogenicity / Q000502:physiology; D012307:Risk Factors; D012907:Smoking
chemical_list: D007375:Interleukin-1