title: 8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src kinase inhibitors.
abstract: A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group.
authors.affiliation: Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. bergerd@wyeth.com
authors.forename: Dan
authors.initials: D
authors.lastname: Berger
authors.forename: Minu
authors.initials: M
authors.lastname: Dutia
authors.forename: Dennis
authors.initials: D
authors.lastname: Powell
authors.forename: Biqi
authors.initials: B
authors.lastname: Wu
authors.forename: Allan
authors.initials: A
authors.lastname: Wissner
authors.forename: Frenel
authors.initials: F
authors.lastname: DeMorin
authors.forename: Jennifer
authors.initials: J
authors.lastname: Weber
authors.forename: Frank
authors.initials: F
authors.lastname: Boschelli
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012995:Solubility; D013329:Structure-Activity Relationship; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D009570:Nitriles; D011804:Quinolines; D019061:src-Family Kinases