Cystic changes in hepatic metastases from gastrointestinal stromal tumors (GISTs) treated with Gleevec (imatinib mesylate).
OBJECTIVE
The purpose of this article is to illustrate the CT findings in patients with hepatic metastases from a gastrointestinal stromal tumor who were treated with STI-571.


CONCLUSIONS
Hepatic metastases from gastrointestinal stromal tumors that respond to treatment with STI-571 can appear as near-cystic components with well-defined borders on contrast-enhanced CT. Most metastases became smaller. These metastases resemble simple cysts, but density measurements may differentiate them from one another.
Chen
Michael Y M
MY
Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1088, USA.
Bechtold
Robert E
RE
Savage
Paul D
PD
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003560:Cysts / Q000000981:diagnostic imaging; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009852:Omentum; D010534:Peritoneal Neoplasms / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013274:Stomach Neoplasms / Q000473:pathology; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011505:Protein-Tyrosine Kinases