title: A multicenter study of the tolerability of tirofiban versus placebo in patients undergoing planned intracoronary stent placement.
abstract: BACKGROUND
  The use of intravenous glycoprotein IIb/IIIa-receptor antagonists has been shown to improve outcomes in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). Tirofiban has shown benefit in a wide range of patients presenting with acute coronary syndromes. Although this agent has been used in patients undergoing percutaneous coronary intervention, a literature search identified no prospective data comparing tirofiban with placebo in patients undergoing planned intracoronary stent placement.
  
  
  OBJECTIVE
  This study examined the tolerability of tirofiban in patients undergoing percutaneous intervention with planned intracoronary stent placement.
  
  
  METHODS
  This was a multinational, multicenter, prospective, randomized, double-blind, placebo-controlled trial in patients scheduled to undergo PTCA with planned intracoronary stent placement. Patients were randomized in a 3:2 ratio to receive tirofiban as an intravenous bolus (10 microg/kg over 3 minutes) and maintenance infusion (0.10 microg/kg per minute for 36 hours) or a bolus and infusion of placebo. All patients received periprocedural aspirin and heparin and an optional postprocedural thienopyridine (ticlopidine or clopidogrel). Laboratory and safety monitoring were performed throughout the 36 hours after the procedure and at hour 40 or hospital discharge. The primary end point was the proportion of patients with bleeding, defined according to Thrombolysis in Myocardial Infarction (TIMI) trial criteria. The number of patients with cardiac events (death, myo- cardial infarction, urgent revascularization) during the first 30 days after stent placement was also assessed.
  
  
  RESULTS
  Eight hundred ninety-four patients (536 tirofiban, 358 placebo) were enrolled, all of whom received aspirin and heparin periprocedurally and optional ticlopidine or clopidogrel after the procedure. No significant between-group differences were observed in the incidence of TIMI major bleeding (0.2% tirofiban, 0.6% placebo) or any TIMI bleeding (3.2% and 1.7%, respectively). The incidence of TIMI minor bleeding was higher with tirofiban than with placebo (2.8% vs 0.6%). The 30-day incidence of the composite end point of any cardiac event was 3.9% in both groups.
  
  
  CONCLUSIONS
  On a background of concomitant aspirin, heparin, and a thienopyridine, tirofiban was generally well tolerated in patients undergoing PTCA with planned intracoronary stent placement. Further investigation is needed to ascertain the optimal dosing of tirofiban and heparin to achieve reductions in ischemic complications of intracoronary stenting with an acceptable incidence of bleeding complications.
authors.affiliation: Department of Cardiology, Liverpool Hospital, Australia. c.juergens@unsw.edu.au
authors.forename: Craig P
authors.initials: CP
authors.lastname: Juergens
authors.forename: Harvey D
authors.initials: HD
authors.lastname: White
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Belardi
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
authors.forename: Jordi
authors.initials: J
authors.lastname: Soler-Soler
authors.forename: Beat J
authors.initials: BJ
authors.lastname: Meyer
authors.forename: Richard D
authors.initials: RD
authors.lastname: Levy
authors.forename: Ton
authors.initials: T
authors.lastname: Bunt
authors.forename: Joris
authors.initials: J
authors.lastname: Menten
authors.forename: Howard C
authors.initials: HC
authors.lastname: Herrmann
authors.forename: A A Jennifer
authors.initials: AA
authors.lastname: Adgey
authors.forename: Georgia
authors.initials: G
authors.lastname: Tarnesby
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D015607:Stents; D000077466:Tirofiban; D014443:Tyrosine / Q000031:analogs & derivatives / Q000627:therapeutic use*
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014443:Tyrosine; D000077466:Tirofiban