Integrin signaling: it's where the action is.
Recent advances highlight a critical role for integrin receptors for extracellular matrix in determining where in cells critical signals are transduced. Integrins are shown to activate signaling intermediates at specific surface membrane locations, to promote nuclear translocation of factors that activate gene transcription, and to recruit and augment the signaling power of receptors for growth factors.
Damsky
Caroline H
CH
Department of Stomatology, School of Dentistry, University of California San Francisco, 94143-0512, USA. damsky@cgl.ucsf.edu
Ilić
Dusko
D
D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured; D005109:Extracellular Matrix; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D015398:Signal Transduction
D006133:Growth Substances; D016023:Integrins