title: [A case of multiple skin metastases from gastric cancer successfully treated with docetaxel combined with doxifluridine].
abstract: The results of treatment of gastric cancer with docetaxel have scarcely been reported. Combination chemotherapy of docetaxel and doxifluridine was administered to five patients with recurrent or unresectable gastric cancer in the authors' department, and the overall response rate was 40%. Among them, we report here a case of multiple skin metastases successfully treated with this chemotherapy. A 71-year-old man had already undergone total gastrectomy with splenectomy about one year previously because of advanced gastric cancer: type 3, tub2, se, n1, INF gamma, ly3(+), v1(+), stage IIIa. He was treated with adjuvant chemotherapy of low-dose FP (CDDP/5-FU) for two weeks, and thereafter 5-FU (200 mg/day orally) was administered. Skin metastases appeared on the right upper eyelid and the left femoral region, though no recurrent findings were detected by CT, US, and the like one year after operation. The combination chemotherapy of docetaxel and doxifluridine was administered because multiple skin tumors rapidly appeared on the back and the right upper eyelid region. These tumors disappeared after 3 weeks and he has had no recurrence more than one year after chemotherapy.
authors.affiliation: Dept. of Surgery, Osaka Prefectural Habikino Hospital.
authors.forename: Tadasu
authors.initials: T
authors.lastname: Mori
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Kimiko
authors.initials: K
authors.lastname: Okamoto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sakata
authors.forename: Kan
authors.initials: K
authors.lastname: Ideguchi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yasumitsu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005467:Floxuridine / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D043823:Taxoids
chemical_list: D043823:Taxoids; D005467:Floxuridine; D000077143:Docetaxel; D017239:Paclitaxel; C025034:doxifluridine