title: Multiple cardiovascular complications in a patient with relapsing polychondritis.
abstract: Relapsing polychondritis is an uncommon disease of unknown etiology, usually manifested by inflammatory changes of cartilaginous tissues. Cardiovascular complications are rare but have been associated with adverse prognosis. Aortitis, vasculitis of large- and medium-sized arteries with aneurysm formation, valvulitis, pericarditis, and atrioventricular conduction disturbances have been reported as late complications of relapsing polychondritis. We describe a 42-year-old man who developed all the known cardiovascular complications of relapsing polychondritis except for clinically evident pericarditis. This case illustrates the multiple, varied, and potentially fatal cardiovascular complications that can occur with this disorder. Patients with relapsing polychondritis should be monitored closely for development of such complications.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA.
authors.forename: Simone N
authors.initials: SN
authors.lastname: Barretto
authors.forename: Guilherme H
authors.initials: GH
authors.lastname: Oliveira
authors.forename: Clement J
authors.initials: CJ
authors.lastname: Michet
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nyman
authors.forename: William D
authors.initials: WD
authors.lastname: Edwards
authors.forename: Iftikhar J
authors.initials: IJ
authors.lastname: Kullo
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D011081:Polychondritis, Relapsing / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome