title: Growth signaling in breast cancer cells: outcomes and promises of proteomics.
abstract: Methods in functional proteomics are now used to study the intracellular signaling pathways that underlie the development of breast cancer. As shown with fibroblast growth factor-2, the oncogenic/non-coding mRNA H19 and 14-3-3 proteins, proteomics is a powerful approach to identify signaling proteins and to decipher the complex signaling circuitry involved in growth of breast cancer cells. Together with genomics, proteomics is now providing a way to define molecular processes involved in breast cancerogenesis and to identify new therapeutic targets.
authors.affiliation: Laboratoire de Biologie du Développement UPRES-EA 1033, Université de Lille1, Bâtiment SN3, Villeneuve d'Ascq Cedex, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Adriaenssens
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lemoine
authors.forename: Ikram
authors.initials: I
authors.lastname: El Yazidi-Belkoura
authors.forename: Hubert
authors.initials: H
authors.lastname: Hondermarck
mesh_terms: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D005092:Exonucleases; D005095:Exoribonucleases; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D006801:Humans; D009363:Neoplasm Proteins; D011506:Proteins / Q000378:metabolism; D020543:Proteome / Q000502:physiology*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014407:Tumor Cells, Cultured
chemical_list: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; C094335:H19 long non-coding RNA; D009363:Neoplasm Proteins; D011506:Proteins; D020543:Proteome; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D016222:Fibroblast Growth Factor 2; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human