title: LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians.
abstract: Low molecular weight polypeptide (LMP) genes are located within the major histocompatibility complex and have been associated with autoimmune diseases such as ankylosing spondylitis. In order to define the distribution of LMP genes in Mexican populations, the LMP2 and LMP7 polymorphism was analyzed in 312 Mexican individuals (95 Mexican Mestizos, 48 Nahuas, 56 Mazatecans, 50 Teenek, and 63 Mayos) belonging to different ethnic groups. In Mexican populations both Mestizos and Amerindians presented similar distribution of LMP2 and LMP7 polymorphisms, except Nahuas and Mayos who presented the higher frequencies of LMP2-H/H and the lowest frequencies of LMP2-H/R genotypes (P < 0.05 when compared with Mexican Mestizos). The LMP7-K/K genotype was absent in Nahuas, Teenek and Mayos and only one Mazatecan individual presented this genotype. Differences with other populations were found in Mexicans. An increased frequency of LMP2-H and a decreased frequency of LMP2-R alleles were observed in Mexican Amerindians (Nahuas and Mayos) when compared with Brazilian Amerindians (Kaingang and Guarani) and Caucasians (Spaniards) (P < 0.05). All Mexican populations (Mestizos and Amerindians) presented an increased frequency of LMP7-Q allele and a decreased frequency of LMP7-K allele when compared to Brazilian Amerindians (Kaingang), Caucasians (United States) and Asian (Japan) populations (P < 0.05). Genetic distances showed that Mexican Mestizos have an important relation with Spaniards and with all Mexican Amerindians. The present data corroborate the influence of Spaniard and Amerindian genes in the Mexican Mestizo population and could help to define the true significance of LMP polymorphism as genetic and evolutive marker in the Amerindian populations.
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chávez, México City, México. gvargas63@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: R
authors.initials: R
authors.lastname: Gamboa
authors.forename: Y
authors.initials: Y
authors.lastname: Vergara
authors.forename: J M
authors.initials: JM
authors.lastname: Rodriguez-Zepeda
authors.forename: A
authors.initials: A
authors.lastname: de la Peña
authors.forename: R
authors.initials: R
authors.lastname: Izaguirre
authors.forename: J
authors.initials: J
authors.lastname: Zuñiga
authors.forename: J A
authors.initials: JA
authors.lastname: Ruiz-Morales
authors.forename: J
authors.initials: J
authors.lastname: Granados
mesh_terms: D005075:Biological Evolution; D003546:Cysteine Endopeptidases / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D008800:Mexico; D009097:Multienzyme Complexes; D011110:Polymorphism, Genetic; D046988:Proteasome Endopeptidase Complex
chemical_list: D005819:Genetic Markers; D009097:Multienzyme Complexes; C071313:LMP-2 protein; D003546:Cysteine Endopeptidases; C077436:LMP7 protein; D046988:Proteasome Endopeptidase Complex