Single-nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer.
E-cadherin plays a major role in intercellular adhesion, cell polarity and tissue architecture. We determined the relative risk of PCa associated with a previously reported C/A SNP at -160 bp relative to the transcription-start site of the E-cadherin gene promoter. Eighty-two PCa patients and 188 controls were genotyped. Genotype and allele frequencies differed significantly among cases and controls. A-allele carriers had a higher relative risk of PCa (OR = 3.6, 95% CI 2.0-6.4) compared to C-only carriers. AC and AA genotypes had an increased risk of PCa (OR = 3.8, 95% CI 2.1-6.8 and OR = 1.7, 95% CI 0.4-6.6, respectively) compared to CC genotypes.
Verhage
Bas A J
BA
Department of Urology (252 EPIB), University Medical Centre Nijmegen, NL-6500 HB Nijmegen, The Netherlands.
van Houwelingen
Kjeld
K
Ruijter
T Emiel G
TE
Kiemeney
Lambertus A
LA
Schalken
Jack A
JA
D000368:Aged; D000483:Alleles; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D012306:Risk
D015820:Cadherins