Cellular longevity: role of apoptosis and replicative senescence.
Cellular longevity refers to the lifespan of an individual cell. Normal cells have a finite lifespan and typically die by undergoing apoptosis, or enter into a state of irreversible growth arrest, termed replicative senescence, at the end of that lifespan. The lifespan of a cell is a balance between pro-survival/anti-apoptotic and pro-apoptotic death-promoting factors. The role of heat shock proteins, Bcl-2 family members, antioxidant molecules, and telomere length and telomerase activity in the regulation of apoptosis and replicative senescence, will be discussed.
Bree
Ronan T
RT
Department of Biochemistry & National Centre for Biomedical Engineering Science, National University of Ireland, Galway, University Road, Galway, Ireland.
Stenson-Cox
Catherine
C
Grealy
Maura
M
Byrnes
Lucy
L
Gorman
Adrienne M
AM
Samali
Afshin
A
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division; D002470:Cell Survival; D016922:Cellular Senescence / Q000502:physiology*; D005544:Forecasting; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism; D016615:Telomere
D006360:Heat-Shock Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D019098:Telomerase