[The effect of some medications used in the treatment of cerebrovascular diseases on free radical oxidation in the model systems].
The effect of 5 medications used in the treatment of ischemic brain lesions on free radical oxidation was studied. The efficacy level was evaluated by chemoluminescent changes in the model systems generating active oxygen species and lipid peroxides radicals. The most active antioxidants inhibiting chemo luminescence proved to be mexidol, cavinton, instenon. Piracetam acts less effectively. Actovegin did not practically display any antioxidant activity. Thus, the medications studied have different effect on free radical oxidation, dysregulation of which underlies many neurological diseases i.e. ischemic blood circulation disorders.
Kolpikova
O S
OS
Farkhutdinov
R R
RR
Magzhanov
R V
RV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D004195:Disease Models, Animal; D005609:Free Radicals / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes / Q000378:metabolism; D008163:Luminescent Measurements; D051381:Rats
D000975:Antioxidants; D005609:Free Radicals; D008081:Liposomes