[Is p53 immunohistochemistry useful for optimal decision for treatment of polypoid lesions in ulcerative colitis?].
BACKGROUND
Usefulness of p53 staining for the differentiation between adenoma and DALM has been reported recently, so recognizable lesions stained positively can be diagnosed as DALMs. For the cases with DALMs, total colectomy has been thought to be necessary.


METHODS
Immunohistochemical staining for p53 was performed in 4 adenocarcinomas and 4 adenomas in ulcerative colitis.


RESULTS
Three carcinomas and 3 adenomas were positive. One carcinoma (protruded mucosal cancer) and 3 adenomas (1 flat elevated lesion and 2 laterally spreading tumors) stained positively for p53 were treated only by polypectomy or local excision. The patients have been under surveillance for periods ranging from 1 to 10 years, during which no metachronous dysplasia has developed.


CONCLUSIONS
These findings suggest that some groups of the polypoid lesions can be resected locally even if stained positively by p53 immunohistochemistry.
Kobayashi
Taku
T
Department of Gastroenterology, Toyohashi Municipal Hospital.
Okamura
Shozo
S
Ohashi
Shinji
S
Urano
Fumihiro
F
Kanamori
Shinichi
S
Hosoi
Tsutomu
T
Kako
Kuniyuki
K
Kurahashi
Masaaki
M
Segawa
Kose
K
Maeda
Matsuyoshi
M
D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003111:Colonic Polyps / Q000209:etiology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D016159:Tumor Suppressor Protein p53