title: Long-term outcome of 56 dogs with nasal tumours treated with four doses of radiation at intervals of seven days.
abstract: A retrospective study was undertaken on 56 dogs treated for nasal tumours by megavoltage radiotherapy with a hypofractionated schedule consisting of four doses of 9 Gy given at intervals of seven days. The dogs were followed until they died or were euthanased. The clinical signs had improved in 53 of the 56 dogs by the end of the treatment schedule. Mild acute radiation side effects were observed in the majority of the dogs but late radiation side effects were rare. Kaplan-Meier survival analysis revealed a median survival time after the final dose of radiation of 212 days. The one- and two-year survival rates were 45 per cent and 15 per cent. Fifty of the dogs were euthanased because the initial clinical signs recurred.
authors.affiliation: Queen Veterinary School Hospital, University of Cambridge.
authors.forename: R J
authors.initials: RJ
authors.lastname: Mellanby
authors.forename: R K
authors.initials: RK
authors.lastname: Stevenson
authors.forename: M E
authors.initials: ME
authors.lastname: Herrtage
authors.forename: R A S
authors.initials: RA
authors.lastname: White
authors.forename: J M
authors.initials: JM
authors.lastname: Dobson
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D009669:Nose Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome