Biopharmaceutical assessment of eye drops containing aloe (Aloe arborescens Mill.) and neomycin sulphate.
The subject of the studies was eye drops made of aloe, containing the group of aloe chemical substances of anti-inflammatory use and neomycin sulphate. The aim of the studies was to evaluate the permeability of biologically active aloe substances, determined as aloenin, through synthetic lipophilic and hydrophilic membranes in a standard perfusion apparatus and in vitro verification of the transport possibilities of these substances through the isolated cornea of pig's eye. The permeability process of biologically active aloe substances determined as aloenin, through synthetic lipophilic and hydrophilic membranes, was analyzed using the first-order kinetics. Estimated quotas of permeability rate constant show that the investigated chemical compounds of aloe, included in the eye drops, diffused through the applied membranes. The studies of permeability through isolated pig's cornea proved that biologically active aloe substances could not overcome this biological barrier. On the basis of biopharmaceutical studies it can be concluded that the eye drops containing aloe and neomycin sulphate, due to the lack of permeating abilities through the eye cornea, should be particularly useful in the treatment of inflammations and infections of external parts of the eye, such as conjuctiva, eyelid edges, lacrimal sac and cornea.
Kodym
Anna
A
Department of Drug Form Technology, Karol Marcinkowski Medical Academy in Poznań.
Grześkowiak
Edmund
E
Partyka
Danuta
D
Marcinkowski
Andrzej
A
Kaczyńska-Dyba
Ewelina
E
D000504:Aloe / Q000737:chemistry; D000818:Animals; D001702:Biopharmaceutics; D003315:Cornea / Q000378:metabolism; D009355:Neomycin / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D018515:Plant Leaves / Q000737:chemistry; D013552:Swine
D009883:Ophthalmic Solutions; D010936:Plant Extracts; D009355:Neomycin