title: Preparation of (99m)Tc-C(60)(OH)(x) and its biodistribution studies.
abstract: The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C(60) derivative for biodistriburtion studies, the (99m)Tc-labeling of C(60)(OH)(x) was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the (99m)Tc-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that (99m)Tc-C(60)(OH)(x) was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h.
authors.affiliation: Shanghai Institute of Nuclear Research, the China Academy of Sciences, P.O. BOX 800-204, Shanghai 201800, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qingnuan
authors.forename: Xiu
authors.initials: X
authors.lastname: yan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xiaodong
authors.forename: Liu
authors.initials: L
authors.lastname: Ruili
authors.forename: Du
authors.initials: D
authors.lastname: qieqie
authors.forename: Shun
authors.initials: S
authors.lastname: Xiaoguang
authors.forename: Chen
authors.initials: C
authors.lastname: Shaoliang
authors.forename: Li
authors.initials: L
authors.lastname: Wenxin
mesh_terms: D000818:Animals; D005260:Female; D037741:Fullerenes / Q000737:chemistry / Q000493:pharmacokinetics*; D007553:Isotope Labeling / Q000379:methods; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013667:Technetium / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D014915:Whole-Body Counting
chemical_list: D037741:Fullerenes; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013667:Technetium; C069837:fullerene C60