[Pharmacological properties od steroid glycosides from Ruscus ponticus].
Some pharmacological properties of the sum of steroidal glycosides (ruscoponin preparation) extracted from underground parts of Ruscus ponticus were studied. The drug exhibits a pronounced antiexudative effect (related to the alpha 1-adrenergic activity) on the models of formalin edema and pouch granuloma in rats and a thermal rectum inflammation in mice. The drug exhibited no hepato-, nephro-, and gastrotoxicity.
Abuladze
G V
GV
Department of Pharmacology, Kuteladze Institute of Pharmaceutical Chemistry, ul. P. Saradzhishvili 36, Tbilisi, 380059 Republic of Georgia.
Mulkidzhanian
K G
KG
Novikova
Zh N
ZhN
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D003092:Colitis / Q000188:drug therapy / Q000209:etiology; D004285:Dogs; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005268:Femoral Vein / Q000187:drug effects / Q000502:physiology; D005557:Formaldehyde; D006027:Glycosides / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006099:Granuloma / Q000188:drug therapy; D006361:Heating; D066298:In Vitro Techniques; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D013256:Steroids / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity
D000893:Anti-Inflammatory Agents; D006027:Glycosides; D028321:Plant Preparations; D013256:Steroids; D005557:Formaldehyde