[Bronchoalveolar lavage in sarcoidosis].
A characteristic feature of BAL in patients with sarcoidosis is an increase of the total cell number, lymphocytes percent, or CD4/CD8 ratio of T lymphocytes. With respect to T lymphocytes, sarcoidosis has been recognized as a granulomatous disease characterized by dominant expression of Th1 cytokines. Recently Th1 cytokine profile in both CD4+ and CD8+ T lymphocytes in BAL fluid were demonstrated at the single-cell level. Furthermore, alveolar macrophages collected from BAL fluid were also investigated. Increased expression of 25-hydroxyvitamin D3 1 alpha-hydroxylase with mRNA level in alveolar macrophage were revealed in active sarcoidosis. Previously we showed that the B allele of the vitamin D receptor gene polymorphism may be regarded as a risk factor in the onset of sarcoidosis. The metabolism of vitamin D may be related to granuloma formation.
Sato
Shigeki
S
Second Department of Internal Medicine, Nagoya City University Medical School.
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000378:metabolism; D018893:Bronchoalveolar Lavage / Q000379:methods*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016516:CD4-CD8 Ratio; D003937:Diagnosis, Differential; D006801:Humans; D016676:Macrophages, Alveolar / Q000378:metabolism; D012507:Sarcoidosis / Q000175:diagnosis*; D014807:Vitamin D / Q000378:metabolism
D014807:Vitamin D; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase