Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria.
By using current NCCLS broth microdilution methods, we found that gatifloxacin inhibited 90% of the isolates of the Mycobacterium fortuitum group at < or =0.12 micro g/ml and 90% of the Mycobacterium chelonae isolates at < or =4 micro g/ml. Gatifloxacin was generally fourfold more active than ciprofloxacin. We recommend that both gatifloxacin and ciprofloxacin be tested routinely against rapidly growing mycobacteria.
Brown-Elliott
Barbara A
BA
Department of Microbiology, University of Texas Health Center, Tyler 75708, USA. barbara.elliott@uthct.edu
Wallace
Richard J
RJ
Crist
Christopher J
CJ
Mann
Linda
L
Wilson
Rebecca W
RW
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006801:Humans; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000145:classification / Q000187:drug effects* / Q000254:growth & development*; D016926:Mycobacterium chelonae / Q000145:classification / Q000187:drug effects / Q000254:growth & development; D019907:Mycobacterium fortuitum / Q000145:classification / Q000187:drug effects / Q000254:growth & development
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D000077734:Gatifloxacin