Expanding distribution of human serotype G6 rotaviruses in Australia.
Serotype G6 rotaviruses are common pathogens of cattle but are rarely found in humans. In Australia, human G6 isolates have previously been detected in two major southern population centres. A new isolate, ASG6.02, was detected in central Australia (Alice Springs) in 1997. Comparison of the deduced amino acid sequence of the major neutralizing antigen, VP7, indicated that ASG6.02 was related to human G6 viruses isolated from children in Italy and Australia. Phylogenetic analysis supported the close relationship between ASG6.02 and other Australian isolates and indicated that G6 VP7 sequences generally clustered according to the species of origin (human, bovine or porcine). The VP4 type of ASG6.02 was determined as P-type [14], in common with other isolates from Australia and Italy. The detection of ASG6.02 indicates that the distribution of this serotype is increasing in this country and may have implications for successful vaccine development.
Diwakarla
Shanti
S
Centre for Applied Colloid and BioColloid Science, School of Engineering and Science, Swinburne University of Technology, Hawthorn, VIC, Australia.
Clark
Ruth
R
Palombo
Enzo A
EA
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral; D001315:Australia; D036022:Capsid Proteins / Q000235:genetics / Q000276:immunology; D002417:Cattle; D002648:Child; D005759:Gastroenteritis / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000821:virology*; D017386:Sequence Homology, Amino Acid; D012703:Serotyping; D013552:Swine
D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus