[Determination of acid-base amphoteric dissociation constant of 2-methyl-5 (4)-nitroimidazole by UV-spectrophotometry].
The 2-methyl-5(4)-nitromidazole(BH) is an ampholyte with acid and base. It is an intermediate of metronidazole. The amphoteric dissociation constant of BH determined by equimolar UV-spectrophotometry. The acidic dissociation constant pKa is 9.64 +/- 0.04 and the basic dissociation constant pKb is 12.98 +/- 0.02.
Yang
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Department of Physical Chemistry, School of Pharmacy, WCUMS, Chengdu 610041.
D008795:Metronidazole; D009593:Nitroimidazoles / Q000032:analysis* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D009593:Nitroimidazoles; D008795:Metronidazole; C052586:2-methyl-5-nitroimidazole