New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa.
A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.
Iwashima
Makoto
M
School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Japan.
Terada
Ikuo
I
Iguchi
Kazuo
K
Yamori
Takao
T
D000475:Alkenes / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001156:Artemia; D002384:Catalysis; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D006865:Hydrogenation; D007564:Japan; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000475:Alkenes; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D013256:Steroids; D004875:Ergosterol