Brasilane-type sesquiterpenoids from Laurencia obtusa.
[structure: see text] Three novel halogenated rearranged sesquiterpenes (1-3) have been isolated along with brasilenol (4) and epibrasilenol (5) from the organic extract of the red alga Laurencia obtusa, collected at Symi island in the Aegean Sea, Greece. The new metabolites possess the unusual skeleton of brasilane and contain the unprecedented 1,6-epoxy moiety. The structures of the new natural products, as well as their relative stereochemistry, were established by means of spectral data analyses, including two-dimensional NMR experiments along with molecular calculations.
Iliopoulou
Dimitra
D
Department of Pharmacy, Division of Pharmacognosy and Chemistry of Natural Products, University of Athens, Panepistimioupolis Zografou, Greece.
Vagias
Constantinos
C
Galanakis
Dimitrios
D
Argyropoulos
Dimitris
D
Roussis
Vassilios
V
D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D000461:Rhodophyta / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification*
D012717:Sesquiterpenes; C467923:brasilane