title: Evidence for diversifying selection in Potato virus Y and in the coat protein of other potyviruses.
abstract: The modes of evolution of the proteins of Potato virus Y were investigated with a maximum-likelihood method based on estimation of the ratio between non-synonymous and synonymous substitution rates. Evidence for diversifying selection was obtained for the 6K2 protein (one amino acid position) and coat protein (24 amino acid positions). Amino acid sites in the coat proteins of other potyviruses (Bean yellow mosaic virus, Yam mosaic virus) were also found to be under diversifying selection. Most of the sites belonged to the N-terminal domain, which is exposed to the exterior of the virion particle. Several of these amino acid positions in the coat proteins were shared between some of these three potyviruses. Identification of diversifying selection events in these different proteins will help to unravel their biological functions and is essential to an understanding of the evolutionary constraints exerted on the potyvirus genome. The hypothesis of a link between evolutionary constraints due to host plants and occurrence of diversifying selection is discussed.
authors.affiliation: Danish Institute of Agricultural Sciences, Biotechnology Group, Thorvaldsensvej 40 1, DK-1871 Frederiksberg C, Denmark2.|Station de Pathologie Végétale, Institut National de la Recherche Agronomique, F-84143 Montfavet cedex, France1.
authors.forename: Benoît
authors.initials: B
authors.lastname: Moury
authors.affiliation: Station de Pathologie Végétale, Institut National de la Recherche Agronomique, F-84143 Montfavet cedex, France1.
authors.forename: Caroline
authors.initials: C
authors.lastname: Morel
authors.affiliation: Danish Institute of Agricultural Sciences, Biotechnology Group, Thorvaldsensvej 40 1, DK-1871 Frederiksberg C, Denmark2.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Johansen
authors.affiliation: Station de Pathologie Végétale, Institut National de la Recherche Agronomique, F-84143 Montfavet cedex, France1.
authors.forename: Mireille
authors.initials: M
authors.lastname: Jacquemond
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D004279:DNA, Viral; D019143:Evolution, Molecular; D014644:Genetic Variation; D008969:Molecular Sequence Data; D016296:Mutagenesis; D010802:Phylogeny; D019176:Potyviridae / Q000145:classification / Q000235:genetics*; D017800:Potyvirus / Q000235:genetics*; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; C090960:coat protein, Potato virus Y