title: [Development of pre-hepatic portal hypertension of the rat].
abstract: OBJECTIVE
  A long-term study of the prehepatic portal hypertension model by triple stenosing ligation of the portal vein in the rat.
  
  
  METHODS
  A cluster analysis of the animals in the different evolutive stages of portal hypertension (1 1/2, 6, 12 and 14 months) has been carried out. This analysis has made it possible to identify three homogeneous groups (A, B and C) in relationship to the liver weight.
  
  
  RESULTS
  The animals with liver atrophy (group C) show a decrease of body, splenic and testicular weights as well as a higher development of the portosystemic collateral circulation in relation to the A and B groups.
  
  
  CONCLUSIONS
  The percentage of animals belonging to the group C decrease progressively during the evolution of portal hypertension and those animals corresponding to the group A, in which is superior the liver weight, increase, while the B group does not change.
authors.affiliation: Facultad de Medicina, Universidad Complutense, Pza. Ramón y Cajal s/n, 28040 Madrid. maaller@med.ucm.es
authors.forename: M A
authors.initials: MA
authors.lastname: Aller Reyero
authors.forename: B
authors.initials: B
authors.lastname: Diéguez Fernández
authors.forename: M P
authors.initials: MP
authors.lastname: Nava Hidalgo
authors.forename: P
authors.initials: P
authors.lastname: Cuesta Alvaro
authors.forename: M
authors.initials: M
authors.lastname: Sánchez García
authors.forename: H J
authors.initials: HJ
authors.lastname: Duran Giménez-Rico
authors.forename: M A
authors.initials: MA
authors.lastname: Llamas Matías
authors.forename: J
authors.initials: J
authors.lastname: Arias Pérez
mesh_terms: D000818:Animals; D001284:Atrophy; D003097:Collateral Circulation; D018450:Disease Progression; D006975:Hypertension, Portal / Q000503:physiopathology; D008026:Ligation; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008297:Male; D023421:Models, Animal; D009929:Organ Size; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar