Age-related changes in the antinociception induced by taurine in mice.
Taurine is a nonessential amino acid that is of medical interest for the nutrition of infants. Taurine has been found in the central nervous system of rodents and humans, and among its potential therapeutic uses, it is interesting to remark its analgesic actions. It is also well known that concentration levels during the fetal and prenatal periods are higher than in adulthood. The data obtained so far indicate that taurine is involved in the development process of the brain and possibly other organs. The taurine levels in old age are still unknown, but it is presumed that they will be different from those of younger animals. Data about age-related alterations and functional modifications of this and other amino acids are still scarce. The aim of the present work was to study the antinociceptive effect of taurine and its relationship with aging in mice. No differences were found between prepubertal and young adult animals; on the contrary, old animals showed significantly reduced sensitivity to the antinociception induced by taurine; in fact, at the tested doses, taurine did not induce antinociception in this group of mice. The mechanism underlying this effect has not been clarified because there are several mechanisms and neurotransmitter systems involved in the antinociception induced by taurine.
Serrano
M I
MI
Pharmacology Unit, Department of Pharmacology, Pediatrics and Radiology, University Hospital of Macarena Medical School, Seville University, 41009, Seville, Spain
Goicoechea
C
C
Serrano
J S
JS
Serrano-Martino
M C
MC
Sánchez
E
E
Martín
M I
MI
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D013654:Taurine / Q000494:pharmacology*
D000700:Analgesics; D013654:Taurine