[Evaluation of gamma-glutamyltransferase activity and reduced glutathione concentration in liver of rats with acute chlorfenvinphos poisoning ].
The aim of this paper was estimation the GGT activity and GSH concentration in the liver of rats intoxicated with chlorfenvinphos. The experiment was conducted on male Wistar rats divided into three groups: control--which received oil and examined--receiving oil solution of chlorfenvinphos in dose of 0.5 LD50 and 0.1 LD50. At the 1st, 24th and 48th hour after intoxication an activity of enzyme was determined. The GGT activity increased after 48th hour of intoxication with the lower dose of insecticide and after 1st, 24th and 48th with higher dose. The GSH concentration increased at the 1st, 24th and 48th hour of intoxication with chlorfenvinphos at dose 0.1 LD50 and at the 24th hour of intoxication with chlorfenvinphos at dose 0.5 LD50. We suppose that increase in the liver GGT activity can result from disturbance in hepatic function. This increase can influence on the reduced glutathione level.
Łukaszewicz-Hussain
Anna
A
Zakład Toksykologii, Akademia Medyczna w Białymstoku 15-222 Białystok, ul. Mickiewicza 2c.
Moniuszko-Jakoniuk
Janina
J
D000818:Animals; D002709:Chlorfenvinphos / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000187:drug effects* / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute; D005723:gamma-Glutamyltransferase / Q000187:drug effects* / Q000378:metabolism
D007306:Insecticides; D005723:gamma-Glutamyltransferase; D002709:Chlorfenvinphos; D005978:Glutathione