CMV retinitis after allogeneic bone marrow transplantation: a report of five cases.
Four cases of cytomegalovirus (CMV) retinitis (CMVR) after allogeneic blood stem cell transplant (SCT) were documented in Huddinge University Hospital between 1994 and 1999. Prior to 1994, only one case was documented. All five patients were transplanted due to malignant disease, two with sibling donors and three with matched unrelated donors. Despite adequate antiviral treatment against CMV retinitis, the result has been almost total unilateral blindness in three patients. However rare, the complication seems to have become more common since we began doing more matched unrelated donor transplants, which leads to a more pronounced T-cell defect and to a delayed immune reconstitution compared to sibling transplants. We conclude that CMV retinitis is a rare but important complication to allogeneic blood stem cell transplantation.
Larsson
Kajsa
K
Department of Haematology, Huddinge University Hospital, SE-14186 Stockholm, Sweden. Kajsa.Larsson@hematol.he.sll.se
Lönnqvist
B
B
Ringdén
O
O
Hedquist
B
B
Ljungman
P
P
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D017245:Foscarnet; D000212:Acyclovir