[Hepatoprotective effect of several constituents of Lonicera fulvotomentosa hsu et S. C. cheng, and L. macranthoide Hand.-Mazz. on CC1(4) and D-galactosamine induced liver injuries in mice and rats].
OBJECTIVE
To study the hepatoprotective effect of several constituents of Lonicera fulvotomentosa and L. macranthoide on CC1(4) and D-Galactosamine induced liver injury in mice and rats.


METHODS
Mice and rats were given s.c. several constituents of L. fulvotomentosa and L. macranthoide, sGPT, hepatic triglycerides(TG) and malondialdehyde (MDA) were determined.


RESULTS
All the compounds reduced the rise of sGPT and TG induced by CC1(4) and D-Galactosamine. Hepatic MDA formation caused by CC1(4) was also significantly decreased.


CONCLUSIONS
Several constituents of L. fulvotomentosa and L. macranthoide are effective in decreasing CC1(4) and D-Galactosamine-induced liver injuries, and this effect appears to be due to the decrease of lipid peroxidation of CC1(4).
Shi
J
J
Guizhou Institute of Traditional Chinese Medicine, Guiyang 550002.
Chen
X
X
Wan
L
L
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005688:Galactosamine; D008099:Liver / Q000378:metabolism; D031239:Lonicera / Q000737:chemistry* / Q000145:classification; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry* / Q000145:classification; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D014280:Triglycerides; D008315:Malondialdehyde; D005688:Galactosamine; D000410:Alanine Transaminase