Uptake across the blood-brain barrier and tissue distribution of enterostatin after peripheral administration in rats.
Enterostatin, the N-terminal activation pentapeptide of procolipase that is produced by the pancreas, reduces food intake from high-fat diet when injected either peripherally or centrally to rats. We investigated uptake across the blood-brain barrier (BBB) and tissue distribution of enterostatin by giving radioactive-labeled enterostatin (3H-VPDPR) intravenously. Low levels of 3H-VPDPR were detected in many areas of the brain, with greatest radioactivity in the frontal cortex, hippocampus and cerebellum. Radioactivity was found in the plasma and all tissues, with the highest amount detected in the pancreas.
Koizumi
Miwako
M
Laboratory of Nutrition, Department of Human Life Science, Graduate School of Human Life Science, Showa Women's University, Tokyo 154-8533, Japan.
Nakanishi
Yukiko
Y
Sato
Hitoshi
H
Morinaga
Yasushi
Y
Ido
Tatuo
T
Kimura
Shuichi
S
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D003089:Colipases / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004792:Enzyme Precursors; D007275:Injections, Intravenous; D008297:Male; D011498:Protein Precursors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014316:Tritium
D003089:Colipases; D004792:Enzyme Precursors; D011498:Protein Precursors; D014316:Tritium; C037107:procolipase