Platelets and anticoagulant capacity in patients with inflammatory bowel disease.
Patients with inflammatory bowel disease (IBD) are susceptible to thromboembolic complications. Several mechanisms can be responsible, including abnormal regulation of coagulation activity, disturbances of fibrinolysis, inflammatory reactions and thrombocytosis. The aim of this study was to assess hemostatic alterations in these parameters during exacerbation of disease. We studied disease activity in 99 IBD patients receiving anti-inflammatory therapy, in relation to: procoagulant markers, i.e. prothrombin fragment F1 + 2 (F1 + 2), D-dimer and platelet count, anticoagulant markers, i.e. protein C, protein S and antithrombin, and a mediator of inflammation (IL-6). Coagulation activity and platelet count were increased during active disease in IBD patients compared with those in a state of remission. The IL-6 concentrations were positively correlated with disease activity and thrombocytosis in patients with ulcerative colitis, but no association with the anticoagulant capacity could be demonstrated except for a decrease in protein C during high disease activity.
Larsen
Torben Bjerregaard
TB
Department of Clinical Biochemistry, Section for Thrombosis and Hemostasis, Aalborg Hospital, Aalborg, Denmark. tblarsen@dadlnet.dk
Nielsen
Jens Nederby
JN
Fredholm
Lisbeth
L
Lund
Erik D
ED
Brandslund
Ivan
I
Munkholm
Pia
P
Hey
Henrik
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D019774:Blood Coagulation Factor Inhibitors / Q000032:analysis / Q000502:physiology*; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013923:Thromboembolism / Q000209:etiology; D019851:Thrombophilia / Q000097:blood
D015415:Biomarkers; D019774:Blood Coagulation Factor Inhibitors; D015850:Interleukin-6