title: Integrin signaling: it's where the action is.
abstract: Recent advances highlight a critical role for integrin receptors for extracellular matrix in determining where in cells critical signals are transduced. Integrins are shown to activate signaling intermediates at specific surface membrane locations, to promote nuclear translocation of factors that activate gene transcription, and to recruit and augment the signaling power of receptors for growth factors.
authors.affiliation: Department of Stomatology, School of Dentistry, University of California San Francisco, 94143-0512, USA. damsky@cgl.ucsf.edu
authors.forename: Caroline H
authors.initials: CH
authors.lastname: Damsky
authors.forename: Dusko
authors.initials: D
authors.lastname: Ilić
mesh_terms: D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured; D005109:Extracellular Matrix; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D015398:Signal Transduction
chemical_list: D006133:Growth Substances; D016023:Integrins