New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis.
Cysticercosis caused by Taenia solium frequently affects human health and rustic porciculture. Cysticerci may localize in the central nervous system of humans causing neurocysticercosis, a major health problem in undeveloped countries. Prevalence and intensity of this disease in pigs and humans are related to social factors (poor personal hygiene, low sanitary conditions, rustic rearing of pigs, open fecalism) and possibly to biological factors such as immunity, genetic background, and gender. The indispensable role of pigs as an obligatory intermediate host in the life cycle offers the possibility of interfering with transmission through vaccination of pigs. An effective vaccine based on three synthetic peptides against pig cysticercosis has been successfully developed and proved effective in experimental and field conditions. The well-defined peptides that constitute the cysticercosis vaccine offer the possibility to explore alternative forms of antigen production and delivery systems that may improve the cost/benefit of this and other vaccines. Encouraging results were obtained in attempts to produce large amounts of these peptides and increased its immunogenicity by expression in recombinant filamentous phage (M13), in transgenic plants (carrots and papaya), and associated to bacterial immunogenic carrier proteins.
Sciutto
Edda
E
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Mexico City, Mexico. edda@servidor.unam.mx
Fragoso
Gladis
G
Manoutcharian
Karen
K
Gevorkian
Goar
G
Rosas-Salgado
Gabriela
G
Hernández-Gonzalez
Marisela
M
Herrera-Estrella
Luis
L
Cabrera-Ponce
José
J
López-Casillas
Fernando
F
González-Bonilla
César
C
Santiago-Machuca
Araceli
A
Ruíz-Pérez
Fernando
F
Sánchez
Joaquín
J
Goldbaum
Fernando
F
Aluja
Aline
A
Larralde
Carlos
C
D000818:Animals; D001483:Base Sequence; D002772:Cholera Toxin / Q000235:genetics / Q000276:immunology; D003551:Cysticercosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D003552:Cysticercus / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D030821:Plants, Genetically Modified; D010957:Plasmids; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology; D013552:Swine / Q000469:parasitology*; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology
D011993:Recombinant Fusion Proteins; D022223:Vaccines, Subunit; D002772:Cholera Toxin