title: Cutaneous neosporosis during treatment of pemphigus foliaceus in a dog.
abstract: A 4-year-old, intact male rottweiler was presented with a 10-day history of papulonodular dermatitis. At the time of presentation, the dog was receiving prednisone and azathioprine to treat pemphigus foliaceus. Cutaneous neosporosis was diagnosed by immunohistochemistry on skin biopsy specimens and a high serum antibody titer to Neospora caninum by Neospora agglutination test. Electron microscopy examination of skin specimens further supported the diagnosis. Clindamycin therapy, together with withdrawal of immunosuppressive medication, resulted in prolonged clinical remission. This report documents cutaneous neosporosis in an adult dog and suggests that immunosuppressive therapy might be a predisposing factor.
authors.affiliation: Department de Medicina i Cirurgia Animal, Veterinary School, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Ordeix
authors.forename: Albert
authors.initials: A
authors.lastname: Lloret
authors.forename: Dolors
authors.initials: D
authors.lastname: Fondevila
authors.forename: J P
authors.initials: JP
authors.lastname: Dubey
authors.forename: Lluis
authors.initials: L
authors.lastname: Ferrer
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fondati
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000977:Antiparasitic Agents; D001379:Azathioprine / Q000009:adverse effects*; D002981:Clindamycin / Q000627:therapeutic use; D003048:Coccidiosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D018688:Neospora / Q000302:isolation & purification / Q000648:ultrastructure; D010392:Pemphigus / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011241:Prednisone / Q000009:adverse effects*; D012876:Skin Diseases, Parasitic / Q000209:etiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D000977:Antiparasitic Agents; D007166:Immunosuppressive Agents; D002981:Clindamycin; D001379:Azathioprine; D011241:Prednisone