Cardiac troponins.
Cardiac troponins I and T are proteins integral to the function of cardiac muscle. They are very sensitive markers for the detection of myocardial damage, and the ability to assay their serum levels accurately and quickly have revolutionized the concepts of minor myocardial injury and infarction. They are also powerful prognostic indicators of future adverse cardiac events. Limitations, more of troponin T than I, include decreased specificity in renal failure and skeletal muscle disease. Rapid, whole blood assays are now available that can be done at the patient's bedside. This review discusses the cardiac troponins, their biochemistry, the assays for them currently available, and their roles in the evaluation of cardiac disease in the Emergency Department (ED).
Sarko
John
J
Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona 85008, USA.
Pollack
Charles V
CV
D015415:Biomarkers / Q000097:blood; D004636:Emergency Service, Hospital; D006331:Heart Diseases / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D019095:Point-of-Care Systems; D011379:Prognosis; D019210:Troponin I / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D020107:Troponin T / Q000097:blood / Q000737:chemistry / Q000378:metabolism
D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T