Familial dyslexia: neurocognitive and genetic correlation in a large Finnish family.
Neuropsychological findings of individuals with dyslexia (n=24) from a large, three-generation Finnish family are presented. We have previously performed whole genome linkage scanning in this family and found that dyslexia in this kindred segregates with a single locus in the pericentromeric area of chromosome 3. Those included in the analyses were carefully evaluated for general cognitive ability, reading and spelling skills, and reading-related neurocognitive skills. The neurocognitive type of dyslexia segregating in this family consisted of deficits in phonological awareness, verbal short-term memory, and rapid naming. Severe dyslexia also seemed to be connected with a general language difficulty and was most common in the eldest generation.
Nopola-Hemmi
Jaana
J
Department of Paediatric Neurology, Hospital for Children and Adolescents, University of Helsinki, Finland. jaana.nopola-hemmi@hus.fi
Myllyluoma
Birgitta
B
Voutilainen
Arja
A
Leinonen
Seija
S
Kere
Juha
J
Ahonen
Timo
T
D000328:Adult; D002648:Child; D003072:Cognition Disorders / Q000235:genetics*; D004410:Dyslexia / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D005387:Finland; D006801:Humans; D007806:Language Disorders / Q000235:genetics*; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D010375:Pedigree