title: Necrotizing sarcoid granulomatosis presenting with elevated serum soluble interleukin-2 receptor levels.
abstract: A 52-year-old woman presented with a one-week history of low-grade fever and dyspnea. A CT scan showed multiple pulmonary nodules with cavitation, as well as bilateral pleural thickenings with effusions. A specimen resected by video-assisted thoracoscopic surgery showed multiple confluent granulomas with central necrosis and granulomatous vasculitis. These findings were consistent with necrotizing sarcoid granulomatosis. An elevated serum soluble interleukin-2 receptor level became normal following clinical and radiological improvement. This indicates that the serum soluble interleukin-2 receptor can be a useful marker for the clinical management of necrotizing sarcoid granulomatosis.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan. t-harada@med.hokudai.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Harada
authors.forename: Toraji
authors.initials: T
authors.lastname: Amano
authors.forename: Ayumu
authors.initials: A
authors.lastname: Takahashi
authors.forename: Jungo
authors.initials: J
authors.lastname: Furuya
authors.forename: Etsuro
authors.initials: E
authors.lastname: Yamaguchi
authors.forename: Mitsuhito
authors.initials: M
authors.lastname: Kaji
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Morikawa
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
authors.forename: Michio
authors.initials: M
authors.lastname: Shimizu
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D006099:Granuloma / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D015375:Receptors, Interleukin-2 / Q000097:blood*; D017565:Sarcoidosis, Pulmonary / Q000097:blood* / Q000150:complications / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2