In vitro activities of investigational triazoles against Fusarium species: effects of inoculum size and incubation time on broth microdilution susceptibility test results.
We studied the effects of inoculum size and incubation time on the susceptibility testing results for various antifungal agents against 22 Fusarium isolates by the NCCLS microdilution method. Increased inoculum size and extended incubation time resulted in elevated MICs. Posaconazole and voriconazole exhibited promising antifungal activities.
Paphitou
Niki I
NI
Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas-Houston Medical School, 77030, USA. GMIX@msn.com
Ostrosky-Zeichner
Luis
L
Paetznick
Victor L
VL
Rodriguez
Jose R
JR
Chen
Enuo
E
Rex
John H
JH
D000935:Antifungal Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003470:Culture Media; D005670:Fusarium / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D011743:Pyrimidines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D003470:Culture Media; D011743:Pyrimidines; D014230:Triazoles; C101425:posaconazole; D065819:Voriconazole