title: High-resolution computed tomography findings are correlated with disease severity in asthma.
abstract: BACKGROUND
  The structural changes in the airways of asthmatics are also referred to as remodeling and can be identified using high-resolution computerized tomography (HRCT).
  
  
  OBJECTIVE
  To find out whether there are any abnormal HRCT features which can be attributed to asthma and their clinical correlates, and any differences of abnormal HRCT features between asthmatics and patients with chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  We performed (HRCT) scans to assess airway remodeling in 160 nonsmoker asthmatics compared with 27 patients with COPD.
  
  
  RESULTS
  Bronchial wall thickening, hyperlucency, centrilobular prominence, bronchiectasis, thick linear opacities and mucoid impaction were all correlated with disease severity in asthma. FEV(1) values were inversely correlated with bronchial wall thickening, hyperlucency, mucoid impaction, linear shadows, centrilobular prominence and bronchiectasis. In addition, thick linear opacities, mucoid impaction and bronchiectasis were more prominent in those patients with a long duration of asthma. Bronchial wall thickening, thick linear opacities, mucoid impaction, bronchiectasis and emphysema were more prominent in COPD patients compared with asthmatics. There was no difference with regard to age, mean values of FEV(1) and the duration of asthma between allergic and nonallergic asthmatics as well as abnormal HRCT findings.
  
  
  CONCLUSIONS
  COPD patients have more prominent HRCT findings as compared with asthmatics. In the asthmatics, abnormal HRCT findings are more prominent with increased severity, decreased FEV(1) values and the duration of asthma. The remodelling of airways in allergic asthmatics did not differ from that in their nonallergic counterparts as determined by HRCT.
authors.affiliation: Department of Pulmonary Diseases, Osmangazi University School of Medicine, Eskisehir, Turkey. emelharm@yahoo.com
authors.forename: Emel
authors.initials: E
authors.lastname: Harmanci
authors.forename: Mahmut
authors.initials: M
authors.lastname: Kebapci
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Metintas
authors.forename: Ragip
authors.initials: R
authors.lastname: Ozkan
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000503:physiopathology; D011856:Radiographic Image Enhancement / Q000379:methods*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods*