title: Lack of association of a single-nucleotide polymorphism of the mu-opioid receptor gene with anxiety-related traits: results from a cross-sectional study of adults and a longitudinal study of children.
abstract: There is evidence from animal experiments that the mu- and delta-opioid receptors may play a role in anxiety and depression. It might therefore be expected that functional polymorphisms of these genes in humans are associated with anxiety and depression. We investigated a single-nucleotide polymorphism (Asn40Asp) of the mu-opioid receptor gene (OPRM1). This association was investigated in two samples: 1) a cross-sectional survey of 867 community-living adults aged 18-79 years who were assessed for anxiety and depression symptoms and related personality traits; and 2) a longitudinal study of childhood temperament in which 660 children were followed from infancy to the mid-teens and assessed for anxiety-related temperament and behavior problems. The data did not support a role for the Asn40Asp polymorphism in anxiety and depression, despite adequate statistical power to detect small effects.
authors.affiliation: Centre for Mental Health Research, Australian National University, Canberra, Australia. Anthony.Jorm@anu.edu.au
authors.forename: Anthony F
authors.initials: AF
authors.lastname: Jorm
authors.forename: Margot
authors.initials: M
authors.lastname: Prior
authors.forename: Ann
authors.initials: A
authors.lastname: Sanson
authors.forename: Diana
authors.initials: D
authors.lastname: Smart
authors.forename: Yafei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Susan
authors.initials: S
authors.lastname: Tan
authors.forename: Simon
authors.initials: S
authors.lastname: Easteal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000235:genetics* / Q000378:metabolism; D002648:Child; D002653:Child Behavior Disorders / Q000235:genetics* / Q000473:pathology; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D010551:Personality / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017450:Receptors, Opioid, mu / Q000235:genetics*; D013694:Temperament
chemical_list: D017450:Receptors, Opioid, mu