title: Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid.
abstract: BACKGROUND
  Tumors of the so-called intrathyroidal epithelial thymoma type are a rare group of thyroid neoplasm tumors. Of this type of tumor, spindle epithelial tumor with thymus like differentiation (SETTLE) has been reported only 17 times in English literature.
  
  
  METHODS
  An 18-year-old woman was initially seen with a 6-cm left thyroid mass that was resected with a left thyroidectomy. Histopathologic features of the excised left thyroid tumor together with an immunohistochemistry and electron microscopy led us to a diagnosis of SETTLE.
  
  
  RESULTS
  Most of the specimen was composed of highly cellular spindle cells that formed intersecting and streaming fascicles. The spindle cells showed both vimentin immunoreactivity and cytokeratin immunoreactivity but no immunoreactivity for thyroglobulin or calcitonin. Electron microscopic examination of the spindle cells demonstrated prominent cytoplasmic tonofilaments, desmosomes, and basal lamina consistent with epithelial cell origin. DNA content analysis by flow cytometry revealed DNA diploidy.
  
  
  CONCLUSIONS
  SETTLE of thyroid gland is an extremely rare entity. A review of the literature reveals that SETTLE has distinctive morphologic features and an immunohistochemical profile.
authors.affiliation: Department of Surgery, Kouseiren Namerikawa Hospital, 119 Tokiwamachl, Namerikawa, Toyama, 9368585 Japan. tomkazu@mx1.fctv.ne.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Iwasa
authors.forename: Miwa Akasofu
authors.initials: MA
authors.lastname: Imai
authors.forename: Masakuni
authors.initials: M
authors.lastname: Noguchi
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Tanaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Shogo
authors.initials: S
authors.lastname: Katsuda
authors.forename: Ei
authors.initials: E
authors.lastname: Kawahara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mizukami
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D011379:Prognosis; D013950:Thymus Gland / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin; D007633:Keratins