title: Multiple hyperkeratotic spicules and myeloma.
abstract: We report the case of a 58-year-old patient with multiple myeloma with a monoclonal gammopathy of the IgG type, who developed a striking eruption characterized by multiple hyperkeratotic spicules of the face, nose and scalp. Light-microscopic studies revealed a follicular orthohyperkeratosis, while direct immunofluorescence microscopy remained negative. Hence, our patient presented features characteristic of a rare distinctive disorder associated with an underlying paraprotein or multiple myeloma, paraneoplastic hyperkeratotic spicules.
authors.affiliation: Department of Dermatology, University Hospital, Geneva, Switzerland. braun@cmu.inige.ch
authors.forename: R P
authors.initials: RP
authors.lastname: Braun
authors.forename: A M
authors.initials: AM
authors.lastname: Skaria
authors.forename: J-H
authors.initials: JH
authors.lastname: Saurat
authors.forename: L
authors.initials: L
authors.lastname: Borradori
mesh_terms: D006801:Humans; D007642:Keratosis / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000473:pathology; D012867:Skin / Q000473:pathology