title: Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human endothelial cells.
abstract: A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery endothelial cells (ECs) and human coronary artery smooth muscle cells (SMCs). Compound was superior to Tranilast, in terms of both cell selectivity and the potency of its inhibitory activity toward the proliferation and angiogenesis of ECs.
authors.affiliation: Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, 3-17-35, Niizo-Minami, Toda-shi, Saitama 335-8502, Japan.
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Ogita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Isobe
authors.forename: Haruo
authors.initials: H
authors.lastname: Takaku
authors.forename: Rena
authors.initials: R
authors.lastname: Sekine
authors.forename: Yuso
authors.initials: Y
authors.lastname: Goto
authors.forename: Satoru
authors.initials: S
authors.lastname: Misawa
authors.forename: Hideya
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects
chemical_list: D000577:Amides; D020533:Angiogenesis Inhibitors; D007202:Indicators and Reagents; D004247:DNA