Design and synthesis of a new bicyclic dipeptide isostere.
The synthesis of a new Gly-Pro turn mimetic and the computational study of its ability to induce beta-turn is reported.
Cordero
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FM
Dipartimento di Chimica Organica Ugo Schiff, Centro di Studio C.N.R. sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni (CSCEA), Università di Firenze, via G. Capponi 9, I-50121 Firenze, Italy. cordero@chimorg.unifi.it
Valenza
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S
Machetti
F
F
Brandi
A
A
D003198:Computer Simulation; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry*; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D017433:Protein Structure, Secondary
D004151:Dipeptides; D011392:Proline; D005998:Glycine