Inhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats.
OBJECTIVE
To investigate the effects and mechanism of succinic acid on pentylenetetrazol (PTZ) chemical kindling and amygdala electrical kindling in rats.


METHODS
PTZ chemical kindling and amygdala electrical kindling models were established in rats. The effects of succinic acid on the behavior and afterdischarge of kindled rats were observed. The mice were pretreated with succinic acid, 30 min later, picrotoxin, a GABAA receptor antagonist was given by ip, then the effects of succinic acid on mice were observed.


RESULTS
Succinic acid (100-400 mg/kg, ip) dose-dependently inhibited PTZ chemical and amygdala kindled seizure (P<0.05, P<0.01), elevated the afterdischarge threshold, and reduced the Racine's stage of amygdala kindling rats (P<0.05, P<0.01); succinic acid (200-400 mg/kg, ip) inhibited picrotoxin-convulsion in mice (P<0.05, P<0.01).


CONCLUSIONS
Succinic acid inhibits PTZ chemical and amygdala electrical kindling in rats, and the inhibition mechanism may be related to the enhancement of GABAergic system action in the brain, especially through GABAA receptors.
Yue
Wang
W
Department of Pharmacology, Medical College, Qingdao University, Qingdao 266021, China. faoqmc@public.qd.sd.cn.
Liu
Yan-Xia
YX
Zang
Dong-Lian
DL
Zhou
Ming
M
Zhang
Fang
F
Wang
Lei
L
D000679:Amygdala; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004558:Electric Stimulation; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D007696:Kindling, Neurologic; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000378:metabolism; D019802:Succinic Acid / Q000627:therapeutic use*
D000927:Anticonvulsants; D018079:Receptors, GABA; D019802:Succinic Acid; D010433:Pentylenetetrazole