title: [Effect of curcumin on the proliferation of murine CFU-GM and WEHI-3B cells].
abstract: OBJECTIVE
  To evaluate the effect of curcumin on the proliferation of hematopoietic progenitor cells or leukemic stem cells.
  
  
  METHODS
  Mouse bone marrow cells (colony forming unit-granulocyte and macrophage, CFU-GM) and WEHI-3B cells were observed using the colony assays.
  
  
  RESULTS
  The curcumin significantly inhibited the proliferation of both CFU-GM and WEHI-3B cells in a dose-dependent manner ranging from 10(-8) to 10(-4) mol.L-1; their IC50S were 1.036 x 10(-5) mol.L-1 and 1.220 x 10(-6) mol.L-1 of curcumin respectively.
  
  
  CONCLUSIONS
  The proliferation of murine CFU-GM and WEHI-3B cells can be suppressed by curcumin. The inhibitory effect of curcumin on the proliferation of WEHI-3B cells is stronger than that of CFU-GM.
authors.affiliation: Research Laboratory of Blood Physiology, Hunan Medical University, Changsha 410078.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Jiang
authors.forename: Q Y
authors.initials: QY
authors.lastname: Xie
authors.forename: Q R
authors.initials: QR
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003474:Curcumin / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D015479:Leukemia, Myelomonocytic, Acute / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004247:DNA; D003474:Curcumin