[Implication of VEGF, steroid hormones and neuropeptides in hair follicle cell responses].
Human hair follicles progress independently through the anagen, catagen, telogen and latency phases that correspond to growth arrest and hair shedding before initiation of a new anagen phase. Hair follicles are self-renewing and contain reservoirs of multi-potent stem cells. Identification of the messenger molecules and pathways operating in the growth and cycling of hair follicles, have provided substantial data. However, only a limited number of these signals is well understood. The specific response of hair follicle cells to these signals is correlated with the expression of their corresponding receptors. What regulates these responses? In this review, we will focus on the hair cycle and its control mechanisms. We will provide some elements in answer to these questions and present some of the markers of hair follicle cells, and hormonal and vascular growth factors, which may regulate respectively hair follicle cell metabolism and cycle, and the neuropeptide impact on hair follicle response and hair growth. The results of our study show the modifications in various expression patterns of receptors in dermal papilla cells, and demonstrate the cross-interaction between these different components. In conclusion, we present an accumulation of evidence suggesting that the regulation of hair growth requires a combination of hormonal, vascular and neuropeptide approaches that will provide further insight in defining new treatments for hair loss.
Castex-Rizzi
N
N
Institut de Recherche Pierre Fabre, Centre Européen de Recherche sur la Peau et les Epithélium de Revêtement, Laboratoire de Biologie Cellulaire Cutanée, 2, rue Viguerie, BP 3071, 31025 Toulouse Cedex 3, France.
Lachgar
S
S
Charvéron
M
M
Gall
Y
Y
D000505:Alopecia / Q000188:drug therapy*; D000728:Androgens / Q000494:pharmacology*; D016228:Endothelial Growth Factors / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D006197:Hair / Q000254:growth & development; D018859:Hair Follicle / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000494:pharmacology*; D009479:Neuropeptides / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D000728:Androgens; D016228:Endothelial Growth Factors; D004967:Estrogens; D008222:Lymphokines; D009479:Neuropeptides; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors