[Reactions between dialkylamine drugs, 2,3-dichloro-1,4-naphthoquinone and acetaldehyde].
Dialkylamine drugs desipramine, propanolol, pindolol, alprenolol and metoprolol 4a-e react with 2,3-dichloro-1,4-naphthoquinone (2) and acetaldehyde to give red coloured 2-dialkylamino-3-chloro-1,4-naphthoquinones 5a, b, d, e, blue coloured 2-dialkylamino-vinyl-3-chloro-1,4-naphtho-quinones 1a-e and bluish green coloured 2-dialkylamino-butadienyl-3-chloro-1,4-naphthoquinones 6b-e. The colour products are isolated by column chromatography.
Kallmayer
H J
HJ
Universität des Saarlandes, Saarbrücken, Germany.
Thierfelder
B
B
D000079:Acetaldehyde / Q000737:chemistry*; D002845:Chromatography; D003124:Colorimetry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D007202:Indicators and Reagents; D009285:Naphthoquinones; D004364:Pharmaceutical Preparations; C007332:dichlone; D000079:Acetaldehyde