title: High-quality protein knowledge resource: SWISS-PROT and TrEMBL.
abstract: SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domain structure, post-translational modifications, variants, etc.), a minimal level of redundancy and a high level of integration with other databases. Together with its automatically annotated supplement TrEMBL, it provides a comprehensive and high-quality view of the current state of knowledge about proteins. Ongoing developments include the further improvement of functional and automatic annotation in the databases including evidence attribution with particular emphasis on the human, archaeal and bacterial proteomes and the provision of additional resources such as the International Protein Index (IPI) and XML format of SWISS-PROT and TrEMBL to the user community.
authors.affiliation: EMBL Outstation, European Bioinformatics Institute, Hinxton, Cambridge, UK. odonovan@ebi.ac.uk
authors.forename: Claire
authors.initials: C
authors.lastname: O'Donovan
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Martin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Gattiker
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Gasteiger
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D006193:Haemophilus influenzae / Q000737:chemistry / Q000235:genetics; D006801:Humans; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology; D020543:Proteome; D040901:Proteomics
chemical_list: D011506:Proteins; D020543:Proteome