title: Is isoniazid ototoxic in patients undergoing hemodialysis?
abstract: Drug-induced ototoxicity might sometimes be a problem in end-stage renal failure (ESRF) patients. However, ototoxicity secondary to isoniazid intake has not been reported in ESRF until now. During the last decade, ototoxicity was diagnosed in 16.6% (7/42) of our ESRF patients undergoing hemodialysis (HD) who also used antituberculosis therapy. Streptomycin was not included in any of these regimens, isoniazid was used by all 7 patients with ototoxicity and there was reversal of hearing loss in 2 of these patients after discontinuation of isoniazid. In our ESRF-HD patients who developed ototoxicity during the course of antituberculosis therapy, isoniazid was probably the responsible agent either alone or it added to the side effects of other drugs.
authors.affiliation: Department of Nephrology, Cerrahpaşa Medical Faculty, University of Istanbul, No:14 Daire:10, Kadíköy-Istanbul, Turkey. onpamuk80@hotmail.com
authors.forename: Mehmet Riza
authors.initials: MR
authors.lastname: Altíparmak
authors.forename: Omer Nuri
authors.initials: ON
authors.lastname: Pamuk
authors.forename: Gülsüm Emel
authors.initials: GE
authors.lastname: Pamuk
authors.forename: Rezzan
authors.initials: R
authors.lastname: Ataman
authors.forename: Kamil
authors.initials: K
authors.lastname: Serdengeçti
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012189:Retrospective Studies; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid