Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease.
Iqbal
Khalid
K
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314-6399, USA. kiqbal@mail.con2.com
Grundke-Iqbal
Inge
I
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D009410:Nerve Degeneration / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000473:pathology*; D009454:Neurofibrils / Q000473:pathology; D013569:Synapses / Q000473:pathology*; D016875:tau Proteins / Q000378:metabolism*
D016875:tau Proteins