title: The treatment of sacral giant-cell tumours by serial arterial embolisation.
abstract: Giant-cell tumours of the sacrum are difficult to treat. Surgery carries a high risk of morbidity, local recurrence and mortality. Radiation is effective in some patients, but has a risk of malignant change. We evaluated the effectiveness of serial arterial embolisation as an alternative to surgery. Five patients with giant-cell tumours of the sacrum which had been primarily treated by serial embolisation were retrospectively reviewed for changes in the size of the tumour. In four the symptoms resolved with full return of function and arrest in the growth of the tumour. They remained free from growth, recurrence, or metastases at follow-up (4 to 17 years). One patient died from metastatic disease within 18 months of the initial diagnosis.
authors.affiliation: Department of Orthopaedic Surgery, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Lackman
authors.forename: L D
authors.initials: LD
authors.lastname: Khoury
authors.forename: A
authors.initials: A
authors.lastname: Esmail
authors.forename: R
authors.initials: R
authors.lastname: Donthineni-Rao
mesh_terms: D000328:Adult; D000792:Angiography; D001859:Bone Neoplasms / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000628:therapy*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012447:Sacrum; D016896:Treatment Outcome