title: Quantitative aspects of signal transduction by the receptor with high affinity for IgE.
abstract: Identification of the major components, how these interact with each other, and the modifications that follow in the sequence of events triggered by the receptor with high affinity for IgE, is progressing rapidly. A new challenge is to understand these interactions quantitatively. We present the fundamentals of the mechanistic model we are testing through mathematical modeling. The object is to see if the predictions of the model fit with the experimental results.
authors.affiliation: Section on Chemical Immunology, Arthritis and Rheumatism Branch, Rm. 9N-228, 10 Center Drive, MSC 1820, NIAMS, NIH, Bethesda, MD 20892-1820, USA. metzgerh@exchange.nih.gov
authors.forename: Henry
authors.initials: H
authors.lastname: Metzger
authors.forename: Santa
authors.initials: S
authors.lastname: Eglite
authors.forename: Hana
authors.initials: H
authors.lastname: Haleem-Smith
authors.forename: Ilona
authors.initials: I
authors.lastname: Reischl
authors.forename: Chikako
authors.initials: C
authors.lastname: Torigoe
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D007700:Kinetics; D018448:Models, Immunological; D008962:Models, Theoretical; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017455:Receptors, IgE / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D000941:Antigens; D017455:Receptors, IgE; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases