title: Bioactive saponins from Dioscorea futschauensis.
abstract: A new anti-neoplastic spirostanol saponin, (25S)-spirost-5-en-3 beta, 27-diol-3O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranoside and three known compounds viz. prosapogenin A of dioscin, dioscin and gracilin were isolated from Dioscorea futschauensis by bioactivity-guided fractionation. Their structures were elucidated mainly by means of spectroscopic analysis. Their bioactivity against Pyricularia oryzae and cytotoxic activity on ts-FT210 cell line was evaluated.
authors.affiliation: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: H W
authors.initials: HW
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Hu
authors.forename: Q C
authors.initials: QC
authors.lastname: Zhao
authors.forename: C B
authors.initials: CB
authors.lastname: Cui
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: X S
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D027742:Dioscorea / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006868:Hydrolysis; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012997:Solvents; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D012997:Solvents