[Stable life prediction for a complex injection of Chinese materia medica by initial average rate stability test].
OBJECTIVE
To predict the stable life for a complex injection of Chinese materia medica.


METHODS
The prediction was carried out by initial average rate stability tests, and the contents of puerarin and danshensu (major active components of the injection) were assayed by HPLC.


RESULTS
The degradation of puerarin followed the first order action, while danshensu was hard to determine; the t0.9,25 degrees C was 3.49 years and 1.69 years respectively.


CONCLUSIONS
The stable life of the injection has been determined as 1.5 years.
Jiang
B
B
Fudan University, Shanghai 200433, China.
Hou
S X
SX
Sun
L L
LL
Liu
S K
SK
Li
Z W
ZW
D004338:Drug Combinations; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007267:Injections; D007529:Isoflavones / Q000032:analysis; D007773:Lactates / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D029908:Pueraria / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid; C033607:puerarin