Is HIF-1alpha a pro- or an anti-apoptotic protein?
Hypoxia-inducible factor-1 (HIF-1) is the major transcription factor specifically activated by hypoxia. It induces the expression of different genes whose products play an adaptive role for hypoxic cells and tissues. Besides these protective responses, HIF-1 and/or hypoxia have also been shown to be either anti-apoptotic or pro-apoptotic, according to the cell type and experimental conditions. More severe or prolonged hypoxia rather induces apoptosis that is, at least in part, initiated by the direct association of HIF-1alpha and p53 and p53-induced gene expression. On the other hand, HIF-1alpha dimerized with ARNT, as an active transcription factor, can protect cells from apoptosis induced by several conditions. This review is aimed to describe the different mechanisms that account for these opposite effects of HIF-1alpha.
Piret
Jean-Pascal
JP
Laboratoire de Biochimie et Biologie cellulaire, University of Namur, 61 rue de Bruxelles, 5000, Namur, Belgium
Mottet
Denis
D
Raes
Martine
M
Michiels
Carine
C
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015687:Cell Hypoxia; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010100:Oxygen / Q000378:metabolism*; D014157:Transcription Factors / Q000502:physiology*
C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors; D010100:Oxygen