title: Sentinel node detection in N0 cancer of the pharynx and larynx.
abstract: Neck lymph node status is the most important factor for prognosis in head and neck squamous cell carcinoma. Sentinel node detection reliably predicts the lymph node status in melanoma and breast cancer patients. This study evaluates the predictive value of sentinel node detection in 50 patients suffering from pharyngeal and laryngeal carcinomas with a N0 neck as assessed by ultrasound imaging. Following 99m-Technetium nanocolloid injection in the perimeter of the tumour intraoperative sentinel node detection was performed during lymph node dissection. Postoperatively the histological results of the sentinel nodes were compared with the excised neck dissection specimen. Identification of sentinel nodes was successful in all 50 patients with a sensitivity of 89%. In eight cases the sentinel node showed nodal disease (pN1). In 41 patients the sentinel node was tumour negative reflecting the correct neck lymph node status (pN0). We observed one false-negative result. In this case the sentinel node was free of tumour, whereas a neighbouring lymph node contained a lymph node metastasis (pN1). Although we have shown, that skipping of nodal basins can occur, this technique still reliably identifies the sentinel nodes of patients with squamous cell carcinoma of the pharynx and larynx. Future studies must show, if sentinel node detection is suitable to limit the extent of lymph node dissection in clinically N0 necks of patients suffering from pharyngeal and laryngeal squamous cell carcinoma.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Philipps-University of Marburg, Deutschhausstr. 3, 35037 Marburg, Germany. j.a.werner@mailer.uni-marburg.de
authors.forename: J A
authors.initials: JA
authors.lastname: Werner
authors.forename: A-A
authors.initials: AA
authors.lastname: Dünne
authors.forename: A
authors.initials: A
authors.lastname: Ramaswamy
authors.forename: B J
authors.initials: BJ
authors.lastname: Folz
authors.forename: B M
authors.initials: BM
authors.lastname: Lippert
authors.forename: R
authors.initials: R
authors.lastname: Moll
authors.forename: Th
authors.initials: T
authors.lastname: Behr
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009367:Neoplasm Staging; D018307:Neoplasms, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy; D013667:Technetium
chemical_list: D013667:Technetium