title: Body mass index in young adulthood and cancer mortality: a retrospective cohort study.
abstract: OBJECTIVE
  To examine the relation between body mass index (BMI) in young adulthood and subsequent mortality from cancer.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  University of Glasgow student health service. Weight and height were measured by a physician, and used to calculate BMI.
  
  
  METHODS
  8335 men and 2340 women who attended the student health service while at university between 1948 and 1968, and who were followed up with the NHS central register.
  
  
  RESULTS
  The main outcome measure was cancer mortality. Three hundred and thirty nine men and 82 women died of cancer during the follow up (mean 41 years). BMI was associated with mortality from all cancers in men and women, although it did not reach conventional statistical significance. The adjusted hazard ratio (HR) (95% CI) per 5 kg/m(2), was 1.22 (0.97 to 1.53) in men and 1.43 (0.95 to 2.16) in women. Two hundred men and 61 women died from cancers not related to smoking. The adjusted HR for mortality from these were 1.36 (1.02 to 1.82) and 1.80 (1.13 to 2.86) respectively. These results are adjusted for height, number of siblings, pulse rate, year of birth, age, smoking, birth order, number of siblings, and age at menarche in women. Site specific analyses, comparing the highest with the lowest quartile of the BMI distribution found increased risks of prostate cancer (n=28) and breast cancer among heavier subjects. No association between BMI and colorectal cancer was found.
  
  
  CONCLUSIONS
  BMI in adolescence has lasting implications for risk of cancer mortality in later life. Future research will include measures of BMI throughout the lifecourse, to determine the period of greatest risk of obesity, in terms of cancer mortality.
authors.affiliation: Department of Social Medicine, University of Bristol, Bristol, UK. Mona.Okasha@bristol.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Okasha
authors.forename: P
authors.initials: P
authors.lastname: McCarron
authors.forename: J
authors.initials: J
authors.lastname: McEwen
authors.forename: G Davey
authors.initials: GD
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000401:mortality / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000401:mortality* / Q000503:physiopathology*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology