Chronology versus biology: telomeres, essential hypertension, and vascular aging.
There is considerable evidence that essential hypertension is closely linked to the growth, development, and aging of human beings. It is imperative, therefore, to introduce biological indicators of growth and aging into models developed to provide a better understanding of the etiology of essential hypertension. One of these indicators may well be the age-dependent telomere attrition rate in somatic cells. Telomere attrition registers the replicative history of somatic cells. As such, it chronicles not only the growth that results from the replication of somatic cells but also their turnover-a process that is strongly linked to inflammation and oxidative stress, which are key factors in the biology of human aging.
Aviv
Abraham
A
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA. avivab@umdnj.edu
D000375:Aging; D001794:Blood Pressure; D004730:Endothelium, Vascular / Q000648:ultrastructure; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D007249:Inflammation / Q000150:complications; D008955:Models, Cardiovascular; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D016615:Telomere / Q000648:ultrastructure*
D017382:Reactive Oxygen Species