Evidence against strong correlation between chest symptoms and ischemic coronary changes after subcutaneous sumatriptan injection.
OBJECTIVE
To evaluate the adverse events possibly caused by sumatriptan injection and explore the relationship between chest symptoms along with sumatriptan injection and coronary ischemia among Japanese patients with migraine.


METHODS
A cumulative total of 112 subcutaneous injections in 62 patients were evaluated. ECG was continuously monitored before and until 5 minutes after injection on 92 occasions.


METHODS
Sixteen men and 46 women aged from 16 to 60 (mean 39+/-12) years. Their clinical diagnoses were migraine with aura, migraine without aura, cluster headache, and others.


RESULTS
Chest symptoms occurred following 17% of all injections and in 15% of all patients. None of these chest symptoms was accompanied by ECG changes.


CONCLUSIONS
Although the risk of coronary ischemia with sumatriptan treatment is commonly stated, our data suggest that chest symptoms following sumatriptan injection are not strongly associated with coronary ischemia in the Japanese population. The mechanism of chest symptoms following sumatriptan administration should be further elucidated.
Tomita
Manami
M
Suzuki
Norihiro
N
Igarashi
Hisaka
H
Endo
Motoi
M
Sakai
Fumihiko
F
D000293:Adolescent; D000328:Adult; D002637:Chest Pain / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007564:Japan; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy; D017202:Myocardial Ischemia / Q000139:chemically induced*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects; D018170:Sumatriptan / Q000008:administration & dosage / Q000009:adverse effects*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000009:adverse effects
D017366:Serotonin Receptor Agonists; D014662:Vasoconstrictor Agents; D018170:Sumatriptan