title: [A clinical research on oxymatrine for the treatment of chronic hepatitis B].
abstract: OBJECTIVE
  To investigate the clinical effect of oxymatrine on chronic viral hepatitis B and to look for new methods for treating hepatitis B.
  
  
  METHODS
  Multi-center, controlled study was used. In this study, 196 patients were allocated to oxymatrine, oxymatrine with Ara-AMP, IFN-a1b, and glucose groups to observe ALT, AST and viral marker changes.
  
  
  RESULTS
  At the end of treatment, the rate of normal ALT, the negative rate of HBV DNA and HBeAg, and the positive rate of HBeAb were similar in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups. It was higher than that of glucose group. After 12 months follow up, the total effective rate is 40.8%, 60.8% and 43.1% in oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b groups, respectively.
  
  
  CONCLUSIONS
  Oxymatrine, oxymatrine with Ara-AMP, and IFN-a1b are effective to treat hepatitis B with a good negative rate of HBV DNA and HBeAg and positive rate of HBeAb.
authors.affiliation: Department of Infectious Diseases, First Teaching Hospital, Peking University, Beijing 100034, China.
authors.forename: Yan Yan
authors.initials: YY
authors.lastname: Yu
authors.forename: Qin Huan
authors.initials: QH
authors.lastname: Wang
authors.forename: Li Min
authors.initials: LM
authors.lastname: Zhu
authors.forename: Qing Bo
authors.initials: QB
authors.lastname: Zhang
authors.forename: Dao Zhen
authors.initials: DZ
authors.lastname: Xu
authors.forename: Yan Bin
authors.initials: YB
authors.lastname: Guo
authors.forename: Chao Quan
authors.initials: CQ
authors.lastname: Wang
authors.forename: Shu Hua
authors.initials: SH
authors.lastname: Guo
authors.forename: Xia Qiu
authors.initials: XQ
authors.lastname: Zhou
authors.forename: Ling Xia
authors.initials: LX
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000470:Alkaloids / Q000009:adverse effects / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011807:Quinolizines; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines