title: T-cell activation: a multidimensional signaling network.
abstract: Naïve T cell activation requires the interactions of antigen receptors, adhesion molecules and co-stimulatory molecules. Antigen receptors and adhesion molecules are involved in spatio-temporal movement to form a stable immunological synapse. This stable junction interrupts T cell migration, and provides a platform for temporally regulated co-stimulatory receptor signaling spanning a period of days.
authors.affiliation: Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Su-Yi
authors.initials: SY
authors.lastname: Tseng
authors.forename: Michael L
authors.initials: ML
authors.lastname: Dustin
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013569:Synapses; D013601:T-Lymphocytes / Q000502:physiology*; D013997:Time Factors