Protein tyrosine kinase Syk in mast cell signaling.
The tyrosine kinase Syk is essential for signaling from FcrepsilonRI in mast cells. The Src homology domain mediated binding of Syk to the phosphorylated immunoreceptor tyrosine-based motif (ITAM) of the receptor subunits results in a conformational change and activation. Studies in Syk deficient mast cells have defined the pathways that are activated upstream and downstream of Syk and have demonstrated the functional importance of the linker region of Syk in signaling in mast cells.
Siraganian
Reuben P
RP
Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N106, Bethesda, MD 20892, USA. rs53x@nih.gov
Zhang
Juan
J
Suzuki
Katsuhiro
K
Sada
Kiyonao
K
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004792:Enzyme Precursors / Q000737:chemistry / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D017493:Leukocyte Common Antigens / Q000502:physiology; D008407:Mast Cells / Q000201:enzymology* / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology*; D017455:Receptors, IgE / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D000072377:Syk Kinase; D014443:Tyrosine / Q000378:metabolism; D051746:ZAP-70 Protein-Tyrosine Kinase
D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D017455:Receptors, IgE; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; D000072377:Syk Kinase; C000606897:Syk protein, mouse; D051746:ZAP-70 Protein-Tyrosine Kinase; C497262:Zap70 protein, mouse; D017493:Leukocyte Common Antigens