title: [Effect of a drug composition containing pyroglutamic acid and pyrrolidone on the cerebral circulation].
abstract: A drug composition containing pyroglutamic acid and pyrrolidone produces a significant effect on the cerebral circulation in rats and cats, which is manifested by increased cerebral blood flow and by a dose-independent improvement of the microcirculation. The cerebrovascular effects were similarly pronounced in both rats and cats which indicates that the drug action is independent of the animal species. The drug combination studied did not exhibit antiserotonin activity. The data obtained show evidence of a substantial contribution of the cerebrovascular component to the neuroprotector action of the drug composition studied.
authors.affiliation: Laboratory of Pharmacology of Cerebrovascular Disorders, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Lun'shina
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
mesh_terms: D000818:Animals; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D008833:Microcirculation; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats
chemical_list: D018696:Neuroprotective Agents; D011760:Pyrrolidinones; D011761:Pyrrolidonecarboxylic Acid