[Detection of the soluble form of the Fas molecule in patients with multiple sclerosis].
We examined the levels of the soluble form of the Fas(sFas) in the cerebrospinal fluids(CSF) and the sera of patients with multiple sclerosis(MS) using an enzyme-linked immunosorbent assay (ELISA). The levels of sera and CSF sFas were significantly higher in MS patients than that in other neurological diseases (OND) group and healthy control(HC); MS patients in the active stage had more sFas molecule than that in the inactive stage. It suggests that sera and CSF sFas may be related to clinical activity in patients with MS, and that sFas may play an important role in the pathogenesis of the MS.
Zhou
W B
WB
Department of Neurology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Hans
L
L
D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid; D019014:fas Receptor / Q000097:blood* / Q000134:cerebrospinal fluid
D019014:fas Receptor