Synthesis and antiproliferative activity in vitro of new 3-substituted aminopyrazolo[3,4-b]pyridines.
The synthesis of several new 3-substituted aminopyrazolo[3,4-b]pyridines is described. The obtained compounds were tested for their antiproliferative activity in vitro. Two of them: 3-chloroacetylaminopyrazolo[3,4-b]pyridine [II] and 3-(2-bromopropionyl-amino)pyrazolo[3.4-b]pyridine [III] revealed cytotoxic activity against the cells of 5 human tumor cell lines applied. Their ID50 values were in the range of the international activity criterion for synthetic agents (4 microg/ml). The structures of the products II-XVII were established on the basis of elemental analysis and spectral data (IR, 1H NMR and MS).
Poreba
Krystyna
K
Department of Technology of Drugs, Wrocław University of Medicine, Poland. krysia@bf.uni.wroc.pl
Opolski
Adam
A
Wietrzyk
Joanna
J
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C434768:3-aminopyrazolo(3,4-b)pyridine; D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D011725:Pyridines