[Ionizing radiation and hyperplasia of the intimal matrix: current data and perspectives].
Vascular reconstruction (bypasses or endoluminal procedures) is still associated with a significant rate of restenosis. For restenosis, smooth muscular cells are the principal actor by their property to migrate, proliferate and secrete extra-cellular substance after their change of phenotype. A variety of pharmacological and mechanical strategies have been directed with limited success. Using ionizing radiation have been recently developed, aiming to reduce the cell proliferation and consecutive restenosis following vessel injury (anastomoses or angioplasty). We reviewed the use of radiations on animals, cellular action and recent clinical trials. Recent clinical trials confirm an effective action of using radiations for restenosis prevention. We reviewed methods of delivering radiations also drawback and consequences using these hopefully methods.
Ducasse
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Service de Chirurgie Vasculaire, Hôpital Saint-Philibert, Groupe Hospitalier de l'Institut Catholique de Lille, 115 rue du Grand But, 59462 Lomme.
Cosset
J M
JM
Eschwege
E
E
Puppinck
P
P
Lartigau
E
E
D000818:Animals; D006801:Humans; D006965:Hyperplasia; D023421:Models, Animal; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000528:radiation effects*; D011839:Radiation, Ionizing; D017539:Tunica Intima / Q000473:pathology / Q000528:radiation effects*