Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody.
Fas antigen (Fas) is a cell surface receptor molecule introducing apoptosis-inducing signals into Fas-bearing cells by stimulation with Fas ligand or agonistic anti-Fas monoclonal antibodies. Fas system has been implicated in the regulation of homeostasis of peripheral T and B lymphocytes including elimination of autoreactive cells, and in the exclusion of tumor and virus-infected cells. Fas system, however, also plays a role in the mechanisms responsible for tissue disruption in tissue-specific autoimmune disease and fulminant hepatitis. In this review, I describe how we prepared the original anti-human Fas monoclonal antibody with associated cell-killing activity, and I propose here a strategy of therapeutic use of a novel anti-Fas monoclonal antibody for autoimmune and other diseases.
Yonehara
Shin
S
Graduate School of Biostudies and Institute for Virus Research, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. syonehar@virus.kyoto-u.ac.jp
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000628:therapy; D006224:Cricetinae; D003429:Cross Reactions; D004195:Disease Models, Animal; D053222:Fas Ligand Protein; D005544:Forecasting; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007157:Immunologic Surveillance / Q000502:physiology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D019463:Mice, Inbred MRL lpr; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D013045:Species Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology; D019014:fas Receptor / Q000276:immunology / Q000502:physiology*
D000911:Antibodies, Monoclonal; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D019014:fas Receptor