Blood substitutes and oxygen therapeutics: an overview and current status.
This review article discusses the development and implementation of a number of blood substitutes, including hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbons. This review article will introduce the reader to blood substitutes by discussing an overview of an ideal blood substitute, the history of HBOCs and perfluorocarbons, strategies of oxygen carrying, side effects of HBOCs and perfluorocarbons, current clinical trials, and the future of blood substitutes.
Jahr
Jonathan S
JS
Department of Anesthesiology, University of California at Los Angeles, Los Angeles, CA 90095-1778, USA. jsjahr@mednet.ucla.edu
Nesargi
Susmita B
SB
Lewis
Kenneth
K
Johnson
Calvin
C
D000818:Animals; D001802:Blood Substitutes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005466:Fluorocarbons / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans
D001802:Blood Substitutes; D005466:Fluorocarbons