Effect of crystal form on in vivo topical anti-inflammatory activity of corticosteroids.
The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the drugs examined, Form B of prednicarbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.
Sohn
Young-Taek
YT
College of Pharmacy, Duksung Womenis University, Tobong-Gu, Seoul, Korea. ytsohn@center.duksung.ac.kr
Kim
Sun-Young
SY
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D018360:Crystallography, X-Ray; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013256:Steroids; D013535:Suspensions
D000893:Anti-Inflammatory Agents; D013256:Steroids; D013535:Suspensions; D016718:Arachidonic Acid