Enlargements of somatosensory-evoked potentials in progressive supranuclear palsy.
OBJECTIVE
To evaluate the usefulness of the somatosensory-evoked potential (SEP) in differentiating progressive supranuclear palsy (PSP) from other movement disorders.


METHODS
The median nerve SEPs were studied in patients with PSP, Parkinson's disease and essential tremor, and in healthy controls.


RESULTS
The amplitudes of the median nerve SEPs were enlarged only in patients with PSP. In four of the 10 patients with PSP, giant SEPs were elicited either unilaterally or bilaterally.


CONCLUSIONS
The enlargement of the SEP in PSP may be useful for early differentiation of PSP, and this enlargement suggest a disease-specific dysfunction in the sensory processing mechanism of PSP which distinguishes it from other movement disorders.
Miwa
H
H
Department of Neurology, Juntendo University School of Medicine, Tokyo Japan. h-miwa@wakayama-med.ac.jp
Mizuno
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D020329:Essential Tremor / Q000175:diagnosis; D005073:Evoked Potentials, Somatosensory; D006801:Humans; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000503:physiopathology*