Does fibrin glue reduce complications after femoral artery surgery? A randomised trial.
OBJECTIVE
to determine whether application of fibrin glue before closure of inguinal wounds reduces the incidence of lymphatic complications.


METHODS
we a prospective randomised trial.


METHODS
224 consecutive patients were enrolled. The wounds were randomly assigned to standard closure (group A, n = 134) or closure with application of fibrin glue (group B, n = 132). The incidence of local lymphatic and non-lymphatic complications, the amount of lymphatic fluid collected, and the time to drain removal were compared in the groups.


RESULTS
the incidence of lymphatic complications was 19% in group A and 10% in group B (p = 0.027). The average drain output and the time to drain removal did not differ in the two groups. The total incidence of non-lymphatic local complications was 10% and did not differ in the two groups.


CONCLUSIONS
fibrin glue application is associated with a significant reduction in lymphatic complications.
Giovannacci
L
L
Surgical Department, Buergerspital Solothurn, Solothurn, Switzerland.
Eugster
Th
T
Stierli
P
P
Hess
P
P
Gürke
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D007264:Inguinal Canal / Q000098:blood supply / Q000601:surgery*; D008206:Lymphatic Diseases / Q000209:etiology* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012086:Reoperation / Q000009:adverse effects; D012307:Risk Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives