title: Clinical signs of cerebellar dysfunction in schizophrenia, alcoholism, and their comorbidity.
abstract: Abnormalities of cerebellar structure and function, long recognized as a hallmark of chronic alcohol abuse, have also occasionally been noted in patients with schizophrenia. We used a four-point rating scale to assess clinical signs of cerebellar dysfunction in men meeting DSM-IV criteria for schizophrenia (N=34) and alcohol dependence (N=15) as well as normal control subjects (N=28). Compared to controls, alcoholics had impaired ratings of gait ataxia and instability of stance with eyes closed, and schizophrenics had impaired ratings of stance with eyes closed. The incidence of dysdiadochokinesia was greater in schizophrenics, but not alcoholics, than controls. The incidence of gait and stance abnormalities was higher in both patient groups relative to controls: within the schizophrenic group, 50-70% of those with positive signs for gait or stance impairment were comorbid for alcoholism, while only 25% of those with positive signs for dysdiadochokinesia were comorbid for alcoholism. The presence of dysdiadochokinesia in the schizophrenic group suggests cerebellar dysfunction that is independent of the effects of alcohol. By contrast, clinical signs of cerebellar dysfunction of gait and stance in patients with schizophrenia may be secondary to the effects of alcohol on the cerebellum.
authors.affiliation: Neuroscience Program, SRI International, , Menlo Park, CA 94025, USA.
authors.forename: Anjali
authors.initials: A
authors.lastname: Deshmukh
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Rosenbloom
authors.forename: Adolf
authors.initials: A
authors.lastname: Pfefferbaum
authors.forename: Edith V
authors.initials: EV
authors.lastname: Sullivan
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology*; D016022:Case-Control Studies; D002526:Cerebellar Diseases / Q000453:epidemiology*; D015897:Comorbidity; D020820:Dyskinesias / Q000453:epidemiology; D020234:Gait Ataxia / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000453:epidemiology*; D019966:Substance-Related Disorders / Q000453:epidemiology