title: Effects of guanethidine administration on compensatory ovarian hypertrophy, compensatory ovulation and follicular development in the prepubertal female guinea pig.
abstract: We analyzed the participation of sympathetic ovarian innervation in the prepubertal female guinea pig on regulation of compensatory ovarian hypertrophy (COH) and compensatory ovulation at puberty. The COH of the left ovary was significantly higher that of the right one (left ovary: 41.5+/-5.2 vs. 27.5+/-5.6%, p<0.05, Kruskal-Wallis test). The sympathetic denervation induced by guanethidine administration beginnings at birth or on day 10 resulted in a significant increase of the COH by each ovary (p<0.05, Kruskal-Wallis test). Only one of the six untreated control guinea pigs sacrificed at the follicular phase ovulate. All the hemiovariectomized animals with the left ovary in situ ovulated, while only two out of five with the right ovary in situ did (100 vs. 40%: p<0.001, Kruskal-Wallis test), unlike the denervated animals, which did not ovulate. The number of corpora lutea present in the ovaries was similar among all groups of animals. These results demonstrate differences in the follicular diameter in untreated female guinea pigs and add further support to the concept of asymmetrical response of the ovaries to denervation.
authors.affiliation: Escuela de Biología. BUAP, Escuela de Biologi;a, Edificio 76, Ciudad Universitaria., Pue, Puebla, Mexico. lriboni@siu.buap.mx
authors.forename: L
authors.initials: L
authors.lastname: Riboni
mesh_terms: D000818:Animals; D004958:Estradiol / Q000097:blood; D005260:Female; D006145:Guanethidine / Q000008:administration & dosage*; D006168:Guinea Pigs; D006984:Hypertrophy; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology*; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects / Q000294:innervation / Q000473:pathology*; D010060:Ovulation; D011374:Progesterone / Q000097:blood; D012741:Sexual Maturation; D013563:Sympathectomy, Chemical
chemical_list: D011374:Progesterone; D004958:Estradiol; D006145:Guanethidine