title: Bioactive glass ceramic particles as an alternative for mastoid obliteration: results in an animal model.
abstract: OBJECTIVE
  This study was conducted to evaluate the use of the bioactive glass ceramic particulate NovaBone Bioglass as a graft material for mastoid cavity obliteration in an animal model.
  
  
  BACKGROUND
  Canal wall down procedures in otologic surgery may result in a problematic mastoid cavity. Mastoid cavity obliteration can potentially prevent or correct this problem. Many techniques and implant materials have been used for mastoid obliteration, but no single graft material has proved to be ideal.
  
  
  METHODS
  Mongolian gerbils received tympanic bulla obliteration using the NovaBone Bioglass particulate. Nine weeks after implantation, the animals were killed, and histologic sections were prepared. Histologic evaluation was performed to evaluate new bone formation within the implant.
  
  
  RESULTS
  Wound healing occurred without complication. Mature trabecular bone was observed throughout the entire thickness of the implant material. Extensive neovascularity was observed within the graft material. There was no histologic evidence of inflammatory reaction or short-term resorption.
  
  
  CONCLUSIONS
  The extensive new bone formation obtained with bioactive glass ceramic particles in this study makes this material a potential alternative resource as a graft material for mastoid obliteration.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock 72205, USA. leathermanbryand@exchange.uams.edu
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Leatherman
authors.forename: John L
authors.initials: JL
authors.lastname: Dornhoffer
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes; D001842:Bone and Bones; D002516:Ceramics / Q000627:therapeutic use*; D005260:Female; D005849:Gerbillinae; D008416:Mastoid / Q000601:surgery*; D019736:Prostheses and Implants; D014432:Tympanic Membrane / Q000601:surgery; D014945:Wound Healing
chemical_list: C022107:Bioglass; D018786:Bone Substitutes