[A study on anti-caries activity of genetic recombinant vaccine of Streptococcus lactis. II. Immunization in vein with recombinant S. lactis in pregnant rabbits].
The effects of immunization in vein with recombinant S. lactis HL107 carring the S. mutans surface protein PAc gene in pregnant rabbits were studied. The results indicated that specific anti-PAc IgG in serum and milk were obviously induced 1 week after immunization and retained at high level for several weeks. It suggests that the recombinant S. lactis HL107 possessing immunogenicity of S. mutans surface protein PAc is able to stimulate specific systemic immune response against PAc.
Liu
J
J
College of Stomatology, Hubei Medical University.
Fan
M
M
Bian
Z
Z
Ling
J
J
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000235:genetics; D003001:Cloning, Molecular; D003731:Dental Caries / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D013294:Lactococcus lactis / Q000235:genetics* / Q000276:immunology; D011247:Pregnancy; D012329:RNA, Bacterial / Q000302:isolation & purification; D011817:Rabbits; D011995:Recombination, Genetic; D022541:Streptococcal Vaccines; D013295:Streptococcus mutans / Q000235:genetics* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D012329:RNA, Bacterial; D022541:Streptococcal Vaccines; D014614:Vaccines, Synthetic