Growth signaling in breast cancer cells: outcomes and promises of proteomics.
Methods in functional proteomics are now used to study the intracellular signaling pathways that underlie the development of breast cancer. As shown with fibroblast growth factor-2, the oncogenic/non-coding mRNA H19 and 14-3-3 proteins, proteomics is a powerful approach to identify signaling proteins and to decipher the complex signaling circuitry involved in growth of breast cancer cells. Together with genomics, proteomics is now providing a way to define molecular processes involved in breast cancerogenesis and to identify new therapeutic targets.
Adriaenssens
Eric
E
Laboratoire de Biologie du Développement UPRES-EA 1033, Université de Lille1, Bâtiment SN3, Villeneuve d'Ascq Cedex, France.
Lemoine
Jérôme
J
El Yazidi-Belkoura
Ikram
I
Hondermarck
Hubert
H
D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D005092:Exonucleases; D005095:Exoribonucleases; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D006801:Humans; D009363:Neoplasm Proteins; D011506:Proteins / Q000378:metabolism; D020543:Proteome / Q000502:physiology*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014407:Tumor Cells, Cultured
D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; C094335:H19 long non-coding RNA; D009363:Neoplasm Proteins; D011506:Proteins; D020543:Proteome; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D016222:Fibroblast Growth Factor 2; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human