[Effect of antibiotic therapy on levels of proinflammatory cytokines: interleukin IL-1, IL-6 and tumor necrosis factor TNF-alpha in serum of patients with Lyme borreliosis].
We estimated serum concentrations of cytokines: IL-1, IL-6, TNF-alpha in patients with diagnosed Lyme disease treated for 14 days with antibiotics. The detection of proinflammatory cytokines was performed by ELISA tests. The examination was carried out before and after the treatment. The comparison with control group stated statistically significant higher concentration of IL-1, IL-6 and TNF-alpha before and after the treatment. Comparing the concentrations of cytokines after treatment with control group showed normalization only in a few cases. In the majority of cases serum cytokines concentrations remained significantly higher. That is why we conclude that 14-day-therapy with antibiotic in patients with Lyme disease may not be sufficient.
Kondrusik
Maciej
M
Kliniki Chorób Zakaźnych i Neuroinfekcji Akademii Medycznej w Białymstoku.
Swierzbińska
Renata
R
Zajkowska
Joanna M
JM
Pancewicz
Sławomir A
SA
Grygorczuk
Sambor
S
Hermanowska-Szpakowicz
Teresa
T
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016207:Cytokines / Q000097:blood*; D004334:Drug Administration Schedule; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008193:Lyme Disease / Q000188:drug therapy* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000900:Anti-Bacterial Agents; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha