title: [A case of gastric carcinoma with metastasis in a paraaortic lymph node that responded to TS-1/CDDP combination therapy, in which the patient was able to undergo extirpation with grade B curability].
abstract: Since the introduction of TS-1 for the treatment of gastric carcinoma, an overall high response rate of cancer to TS-1 therapy has been recognized. Therefore, TS-1 in combination with cisplatin (CDDP) can be reasonably expected to be an effective new strategy for the treatment of advanced gastric carcinoma. We administered three courses of the TS-1/CDDP combination in a case of gastric carcinoma with metastasis in a paraaortic lymph node. Regression of the primary carcinoma (72.7% decrease in tumor mass) and reduction in size of the lymph node were observed. Consequently, the patient underwent total gastrectomy, resection of the splenic arterial trunk, splenectomy and D3 lymph node dissection, which resulted in grade B curability. The state of the patient was favorable both at the time of surgery and postoperatively, and the course of therapy remained uneventful. Although grade 1 nausea and vomiting were noted as adverse reactions to the treatment resulting in insufficient oral intake and necessitating intravenous infusion in the hospital, the treatment was completed without any other adverse events during the course of the therapy.
authors.affiliation: Dept. of Surgery, Saiseikai Suita Hospital.
authors.forename: Akinori
authors.initials: A
authors.lastname: Hara
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Harada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsunematu
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Izumi
authors.forename: Shinji
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Kazunari
authors.initials: K
authors.lastname: Satake
authors.forename: Haruo
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Takehiko
authors.initials: T
authors.lastname: Shiomi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001011:Aorta; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin