[Does intake of gastric acid pump inhibitor affect the evaluation of the Lundh test?].
BACKGROUND
The aim of this study was to evaluate the effect of inhibition of gastric acid secretion on postprandial pancreatic secretion. MATERIAL OG METHODS: Fifteen healthy subjects and seven patients with chronic pancreatitis were entered in a randomised, double-blind, cross-over study of the exocrine pancreatic function after placebo or omeprazole 80 mg daily for three days. The exocrine pancreatic function was evaluated with the Lundh test. The pH was determined in the duodenum, and CCK and secretin were determined in plasma.


RESULTS
As expected, a higher intraduodenal pH was found after inhibition of the gastric acid secretion, but no significant difference was seen in the concentration of pancreatic amylase in the duodenum. None of the subjects changed their diagnostic category during the test. Except for those with pancreatic insufficiency, in whom plasma secretin was lower after omeprazole, inhibition of gastric acid secretion had no effect on CCK or secretin in plasma.


CONCLUSIONS
Inhibition of gastric acid secretion with high doses of omeprazole does not alter postprandial intraduodenal concentrations of alpha-amylase. It does not, therefore affect the evaluation of the Lundh test.
Damborg
Frank
F
Odense Universitetshospital, medicinsk gastroenterologisk afdeling S.
Damborg
Sanne Bornholdt
SB
Schaffalitzky de Muckadell
Ove B
OB
D000328:Adult; D000681:Amylases / Q000378:metabolism; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004386:Duodenum / Q000201:enzymology / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D010179:Pancreas / Q000201:enzymology / Q000378:metabolism*; D010186:Pancreatic Function Tests / Q000379:methods*; D010195:Pancreatitis / Q000201:enzymology / Q000503:physiopathology*
D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D000681:Amylases; D009853:Omeprazole