title: Microbial transformation of hydrocortisone by Acremonium strictum PTCC 5282.
abstract: The ability of a genus of cephalosporium-like fungus isolated from soil, Acremonium strictum PTCC 5282, for hydrocortisone biotransformation has been investigated. This potential had not been previously examined. The fermentation yielded 11beta,17beta-dihydroxyandrost-4-en-3-one, 11beta,17alpha,20beta,21-tetrahydroxypregn-4-en-3-one and 21-acetoxy-11beta,17alpha,20-trihydroxypregn-4-en-3-one. Each microbial metabolite was purified and characterized using spectroscopic methods.
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, 14174, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faramarzi
authors.forename: Mojtaba Tabatabaei
authors.initials: MT
authors.lastname: Yazdi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Zarrini
mesh_terms: D000164:Acremonium / Q000378:metabolism*; D000732:Androstanols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D001711:Biotransformation; D003460:Crystallization; D005285:Fermentation; D006854:Hydrocortisone / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000732:Androstanols; D006854:Hydrocortisone