title: Progressive loss of cardiac sympathetic innervation in Parkinson's disease.
abstract: This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6-[(18)F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6-[(18)F]fluorodopamine-derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying-back mechanism.
authors.affiliation: Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1620, USA. lishen@ninds.nih.gov
authors.forename: Sheng-Ting
authors.initials: ST
authors.lastname: Li
authors.forename: Raghuveer
authors.initials: R
authors.lastname: Dendi
authors.forename: Courtney
authors.initials: C
authors.lastname: Holmes
authors.forename: David S
authors.initials: DS
authors.lastname: Goldstein
mesh_terms: D018450:Disease Progression; D004298:Dopamine / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000150:complications; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; C029253:6-fluorodopamine; D004298:Dopamine