title: Actin nucleation: cortactin caught in the act.
abstract: A variety of activators stimulate Arp2/3 complex to nucleate branched actin filament structures. New results provide important biochemical and structural information for activation by the proteins cortactin and N-WASP.
authors.affiliation: Dartmouth Medical School, Hanover, NH 03755-3844, USA. Henry.N.Higgs@Dartmouth.edu
authors.forename: Henry N
authors.initials: HN
authors.lastname: Higgs
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry* / Q000648:ultrastructure; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000737:chemistry*; D020816:Amino Acid Motifs; D000818:Animals; D051356:Cortactin; D003432:Cross-Linking Reagents / Q000494:pharmacology; D003598:Cytoskeletal Proteins / Q000502:physiology; D006801:Humans; D046911:Macromolecular Substances; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000502:physiology; D011485:Protein Binding; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D021122:Protein Subunits; D017384:Sequence Deletion; D015398:Signal Transduction / Q000502:physiology; D013045:Species Specificity; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal
chemical_list: C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; C495868:CTTN protein, human; D051356:Cortactin; D003432:Cross-Linking Reagents; D003598:Cytoskeletal Proteins; D046911:Macromolecular Substances; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D021122:Protein Subunits; C495771:WASL protein, human; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal