Integrin-associated proteins.
A diverse group of plasma membrane proteins have been found associated with integrins in supramolecular complexes. These associated plasma membrane molecules can modulate virtually all integrin functions by altering signal transduction arising from integrin ligation. In the past two years, new examples of signaling through heterotrimeric G proteins and regulation by membrane rafts have emphasized their importance in the function of integrin-containing supramolecular complexes.
Brown
Eric J
EJ
Program in Host--Pathogen Interactions, University of California, San Francisco, CA 94143, USA. ebrown@medicine.ucsf.edu
D000818:Animals; D002450:Cell Communication; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism*; D011485:Protein Binding; D015398:Signal Transduction
D016023:Integrins