title: Hepatobiliary scanning in the diagnosis of biliary atresia.
abstract: Early diagnosis is vital in the neonatal cholestasis. The aim of this study was to assess the usefulness of hepatobiliary scanning in the diagnosis of biliary atresia. 33 hepatobiliary scannings performed in 30 children with cholestasis over the last two years were analysed. The mean age at the diagnosis was 6.6 weeks. The investigation was carried out with Multispect camera using intravenous infusion of 99mTc-MBrIDA. In 23 patients there was no passage of the radiolabelled substance into the intestinal tract. In 18 patients biliary atresia was diagnosed. One patient with a clinical suspicion of Alagille syndrome had two scannings performed at the interval of two weeks. In 1 child a common biliary tract cyst with total obstruction of extrahepatic biliary tree was diagnosed. In 18 children with biliary atresia the diagnosis was confirmed during the operation and Kasai procedure was performed. In 2 children the second scanning showed bile drainage. In 3 children intrahepatic cholestasis was diagnosed in addition to the bile passage failure. Hepatobiliary scanning in the diagnosis of neonatal cholestasis was characterised by high sensitivity (100%) but lower specificity (75%). In difficult cases the final diagnosis should be made on a basis of complex clinical, biochemical and radiological techniques and, if necessary, it should be verified by intraoperative cholangiography.
authors.affiliation: Department of Nuclear Medicine, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-736 Warszawa. liver@czd.waw.pl
authors.forename: A
authors.initials: A
authors.lastname: Kamińska
authors.forename: J
authors.initials: J
authors.lastname: Pawłowska
authors.forename: I
authors.initials: I
authors.lastname: Jankowska
authors.forename: E
authors.initials: E
authors.lastname: Swiatek-Rawa
authors.forename: P
authors.initials: P
authors.lastname: Socha
authors.forename: A
authors.initials: A
authors.lastname: Kamiński
authors.forename: M
authors.initials: M
authors.lastname: Teisseyre
authors.forename: P
authors.initials: P
authors.lastname: Czubkowski
authors.forename: K
authors.initials: K
authors.lastname: Toth
mesh_terms: D001656:Biliary Atresia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006505:Hepatitis / Q000175:diagnosis; D006801:Humans; D007223:Infant; D013997:Time Factors; D014463:Ultrasonography