[Preventive effect of cardiomyopeptidin on rat heart injured by ischemia-reperfusion].
OBJECTIVE
To investigate the preventive effect of cardiomyopeptidin of small molecular weight polypeptide on rat hearts injured by ischemia-reperfusion.


METHODS
In a rat model injured by ischemia-reperfusion in the heart, observation was made on the influence of cardiomyopeptidin on the activities of creatine kinase (CK) and lactate dehydrogenase(LDH), as well as on the content of MDA in plasma after the preventive drug was used.


RESULTS
Cardiomyopeptidin could obviously prevent the injury caused by ischemia-reperfusion, reduce the activities of CK and LDH and the content of MDA in a dose-dependent manner.


CONCLUSIONS
Cardiomyopeptidin has a preventive effect on myocardium injured by ischemia-reperfusion and this may be related to its reducing the release of myocardial enzyme and anti-lipoperoxidation.
Yang
L P
LP
Department of Molecular Biology, Infectious Diseases Center, 458th Hospital of PLA, Guangdong, Guangzhou 510602, China.
Wan
H Y
HY
Kong
X P
XP
Wu
Y
Y
Teng
J
J
Fan
L L
LL
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008419:Materia Medica / Q000627:therapeutic use*; D008970:Molecular Weight; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000517:prevention & control*; D009206:Myocardium / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013552:Swine
D008419:Materia Medica; D010455:Peptides; C470986:cardiomyopeptidin; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase