Ventilator-induced lung injury: in vivo and in vitro mechanisms.
A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.
Matthay
Michael A
MA
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143-0130, USA. mmatt@itsa.ucsf.edu
Bhattacharya
Sunita
S
Gaver
Donald
D
Ware
Lorraine B
LB
Lim
Lina H K
LH
Syrkina
Olga
O
Eyal
Fabien
F
Hubmayr
Rolf
R
D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000276:immunology / Q000503:physiopathology*; D055370:Lung Injury; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D012121:Respiration, Artificial / Q000009:adverse effects*; D013314:Stress, Mechanical