title: Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats.
abstract: The glucose-lowering efficacy of a methanol extract of the stem bark of Ficus racemosa Linn. (MEBFR) (Family Moraceae) was evaluated both in normal and alloxan-induced diabetic rats. The MEBFR at the doses examined (200 and 400 mg/kg p.o.) exhibited significant hypoglycaemic activity in both experimental animal models when compared with the control group. The activity was also comparable to that of the effect produced by a standard antidiabetic agent, glibenclamide 10 mg/kg. The present investigation established pharmacological evidence to support the folklore claim that it is an antidiabetic agent.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta-700 032, India.
authors.forename: R
authors.initials: R
authors.lastname: Bhaskara Rao
authors.forename: T
authors.initials: T
authors.lastname: Murugesan
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Sinha
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Mandal
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D030681:Ficus; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007928:Lethal Dose 50; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate; D018675:Toxicity Tests
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005905:Glyburide