[Anticipation in familial malignant hematologic diseases (epidemiologic observations)].
Between January 1 1983 and December 31 2000, 21 cases of association of haematologic malignancies between parents and their children, two cases of that in grandparents and their grandchildren, and five cases of appearances of haematologic malignancies in uncle or aunt and their nephew or niece were experienced by authors. The diseases manifested in the second (or in the third) generation in 25/28 cases appeared earlier than those in the first generation, and in 13/28 cases had a greater malignity. In the remaining 15 cases the malignity was identical in both generation. Instead of anticipation (greater severity and/or earlier onset) the term dual acceleration (earlier onset and greater malignity) is more exact and thus more proper determine epidemiologic observations of authors. Dual acceleration was proved by authors not only in identical but in different haematologic malignancies manifested both in first-degree and second-degree relatives.
Jakó
János
J
Szabolcs-Szatmár-Bereg Megyei Onkormányzat Jósa András Kórháza, II. Belgyógyászati Osztály-Hematológia, Nyíregyháza.
Szerafin
László
L
Nagy
Péter
P
Babicz
Tamás
T
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D020132:Anticipation, Genetic; D002648:Child; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007938:Leukemia / Q000453:epidemiology / Q000235:genetics; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index