title: Dynamic kinetic resolution of 2-oxocycloalkanecarbonitriles: chemoenzymatic syntheses of optically active yclic beta- and gamma-amino alcohols.
abstract: A series of fungi and yeasts have been tested for the stereoselective bioreduction of 2-oxocycloalkanecarbonitriles, 1. The yeast Saccharomyces montanus CBS 6772 yielded the corresponding cis-hydroxy nitriles, 2, in >90% ee and de and in high chemical yields. Through simple and efficient procedures, they were transformed into optically active 2-amino and 2-aminomethyl cycloalkanols.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, c/Julián Clavería, 8, E-33006 Oviedo, Spain vgs@sauron.quimica.uniovi.es
authors.forename: Juan R
authors.initials: JR
authors.lastname: Dehli
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor