title: A uropathogenicity island contributes to the pathogenicity of Escherichia coli strains that cause neonatal meningitis.
abstract: We report that the archetypal Escherichia coli strain C5 causing neonatal meningitis harbors a pathogenicity island (PAI) designated PAI I(C5) that is similar to the PAI II(J96) of uropathogenic E. coli J96 inserted in the leuX-tRNA gene. PAI-negative C5 mutants had a lower capacity than C5 to induce high-level bacteremia in a neonatal rat model. However, no change in their resistance to the bactericidal effect of serum and their capacity to cross the blood-brain barrier was observed.
authors.affiliation: Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Hôpital Robert Debré, 75019 Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Houdouin
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
authors.forename: Naima
authors.initials: N
authors.lastname: Brahimi
authors.forename: Olivier
authors.initials: O
authors.lastname: Clermont
authors.forename: Xavier
authors.initials: X
authors.lastname: Nassif
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000382:microbiology; D001483:Base Sequence; D001770:Blood Bactericidal Activity; D004269:DNA, Bacterial / Q000235:genetics; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000235:genetics* / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D007231:Infant, Newborn; D020814:Meningitis, Escherichia coli / Q000382:microbiology*; D008969:Molecular Sequence Data; D051381:Rats; D017207:Rats, Sprague-Dawley; D017384:Sequence Deletion; D014774:Virulence / Q000235:genetics
chemical_list: D004269:DNA, Bacterial