The first Ru(II)-catalysed asymmetric hydrogen transfer reduction of aromatic ketones in aqueous media.
The first water-soluble asymmetric hydrogen-transfer ruthenium(II) catalyst system consisting of [Ru(p-cymene)Cl2]2, (S)-proline amide, and sodium formate, which gives high conversion rates with high ee values up to 95.3% and is reusable, has been developed.
Rhyoo
H Y
HY
School of Chemistry and Center for Molecular Catalysis, Seoul National University, Seoul 151-747, Korea.
Park
H J
HJ
Chung
Y K
YK