Design and synthesis of isoindoloquinoline derivatives as potential antitumor agents.
A series of isoindoloquinoline derivatives was synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HCT15, SK-OV-3, MDA-MB-468 and T-47D).
Lee
Heesoon
H
College of Pharmacy, Chungbuk National University, Cheongju, Korea. medchem@trut.chungbuk.ac.kr
Jeong
Ilyeong
I
Yang
Sung-Il
SI
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D020029:Base Pairing / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007211:Indoles; D007364:Intercalating Agents; D011804:Quinolines; D004247:DNA