title: [Pancreatic anastomotic fistula after pancreaticoduodenectomy: incidence, significance and treatment].
abstract: The Authors reviewed the complications, and outcomes in a consecutives series of 97 patients undergoing pancreaticoduodenectomy. The clinical leak rate in this series was 21.8%. There was a difference in the pancreatic leak rate in those patients who underwent pancreatic ductal closure or end to end pancreaticojejunal invagination compared with end to side pancreaticojejunal anastomosis. The postoperative complication rate was 41.8% and the most common complications were pancreatic fistula. 9 deaths occurred in hospital or within 30 days from operation. Univariate and multivariate analysis revealed that operative technique, the pathological status of the pancreatic remnant, and mayor complications were the significant risk factors for the development of pancreatic anastomotic leak. In the 2000s pancreatic leak remains a potentially lethal problem. After pancreaticoduodenectomy, pancreatic remnant management by end to side pancreaticojejunostomy appeared safe in low-risk patients. Morbidity was greatest after pancreatic duct closure without anastomosis.
authors.affiliation: Dipartimento di Chirurgia Pietro Valdoni, Università degli Studi di Roma La Sapienza.
authors.forename: A
authors.initials: A
authors.lastname: Tocchi
authors.forename: L
authors.initials: L
authors.lastname: Lepre
authors.forename: G
authors.initials: G
authors.lastname: Mazzoni
authors.forename: G
authors.initials: G
authors.lastname: Costa
authors.forename: G
authors.initials: G
authors.lastname: Liotta
authors.forename: M
authors.initials: M
authors.lastname: Miccini
authors.forename: E
authors.initials: E
authors.lastname: Bettelli
authors.forename: D
authors.initials: D
authors.lastname: Cassini
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000714:Anastomosis, Surgical / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010185:Pancreatic Fistula / Q000209:etiology*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000379:methods; D010193:Pancreaticojejunostomy; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors