Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents.
N-Benzyl pyrrolidinyl sordaricin derivatives have been synthesized from cis-4-hydroxy-D-proline in a stereocontrolled manner. These compounds maintained moderate antifungal activity against several pathogenic fungal strains. Their MIC values against Candida albicans were in the range of 0.25-2 microg/mL.
Arai
Masami
M
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 2-58, Hiromachi 1-chome, Shinagawa-ku, Tokyo, Japan.
Harasaki
Tamako
T
Fukuoka
Takashi
T
Kaneko
Satoru
S
Konosu
Toshiyuki
T
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004224:Diterpenes; D015725:Fluconazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D004224:Diterpenes; D007202:Indicators and Reagents; D011760:Pyrrolidinones; C116705:sordaricin; D015725:Fluconazole