title: Alterations of acute phase reaction and cytokine production in patients following severe burn injury.
abstract: To determine the acute immunologic reaction, mediated by cytokines, interleukines (ILs) and growth factors and the susceptibility to infections and sepsis after severe burn injury a prospective, single unit, longitudinal study of acute phase reactants and mediators who performed. After approval by the ethics committee of our hospital, we investigated the plasma concentrations of IL-2, -6, -8, -10, and -13, the soluble IL-2 receptor (sIL-2R), and the acute phase proteins procalcitonin (PCT) and C-reactive protein (CRP) at admission and every 3 days in 24 patients over a time course of 28 days after thermal injury and categorized by percent burn: < or =30% (group 1; n=12) and >30% (group 2; n=12). Shortly after burn injury we found higher concentrations of IL-2, -6, -10 and PCT in those patients >30% TBSA. During the study period, we found significant higher levels of acute phase proteins, IL-6 and -8 in patients >30% TBSA. The incidence of SIRS and MODS was three times increased in patients >30% TBSA. Our results show different patterns of cytokines and acute phase proteins in patients with different burned surface areas over a long time and continuous monitoring of a more distinct inflammatory response in these patients.
authors.affiliation: Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Strasse 7, Germany. marius.g.dehne@chiru.med.uni-giessen.de
authors.forename: Marius G
authors.initials: MG
authors.lastname: Dehne
authors.forename: Armin
authors.initials: A
authors.lastname: Sablotzki
authors.forename: Andreas
authors.initials: A
authors.lastname: Hoffmann
authors.forename: Jörg
authors.initials: J
authors.lastname: Mühling
authors.forename: Friedrich E
authors.initials: FE
authors.lastname: Dietrich
authors.forename: Gunter
authors.initials: G
authors.lastname: Hempelmann
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D000210:Acute-Phase Reaction / Q000097:blood*; D000328:Adult; D000704:Analysis of Variance; D002056:Burns / Q000097:blood*; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D013997:Time Factors
chemical_list: D000209:Acute-Phase Proteins; C000606589:CALCA protein, human; D016207:Cytokines; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide