title: Cytotoxic mycosis fungoides evolving from pityriasis lichenoides chronica in a seventeen-year-old girl. Report of a case.
abstract: Pityriasis lichenoides chronica and its acute form, pityriasis lichenoides et varioliformis acuta, are skin diseases of unknown origin, that probably represent a hypersensitivity reaction to an infective agent. Pityriasis lichenoides is often a benign disorder but, because of the presence of a clonal T cell population detected both in the chronic and acute forms, some authors have suggested that it may belong to the group of primary cutaneous T cell lymphomas. Although various studies have clearly documented no significant association between pityriasis lichenoides and malignant lymphomas, cases of long-standing pityriasis lichenoides evolving into mycosis fungoides have been described. Herein we report the case of a girl suffering from pityriasis lichenoides since the age of 11 years, subsequently developing a CD45RO+, CD8+, TIA-1+ mycosis fungoides.
authors.affiliation: Department of Dermatology, Hospital of Busto Arsizio, Italy. dartomasini@libero.it
authors.forename: Dario
authors.initials: D
authors.lastname: Tomasini
authors.forename: Clementina
authors.initials: C
authors.lastname: Zampatti
authors.forename: Gabriele
authors.initials: G
authors.lastname: Palmedo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bonfacini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sangalli
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
mesh_terms: D000293:Adolescent; D000951:Antigens, Neoplasm / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D008214:Lymphocytes / Q000473:pathology; D008565:Membrane Proteins / Q000032:analysis; D009182:Mycosis Fungoides / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D017514:Pityriasis Lichenoides / Q000150:complications* / Q000473:pathology; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000074019:T-Cell Intracellular Antigen-1
chemical_list: D000951:Antigens, Neoplasm; D016827:CD8 Antigens; D008565:Membrane Proteins; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; D017493:Leukocyte Common Antigens