Plasma stromal cell-derived factor (SDF)-1 levels, SDF1-3'A genotype, and expression of CXCR4 on T lymphocytes: their impact on resistance to human immunodeficiency virus type 1 infection and its progression.
Plasma stromal cell-derived factor (SDF)-1 levels, SDF1-3'A polymorphism, and CXCR4(+) T lymphocytes in relation to resistance to human immunodeficiency virus (HIV)-1 infection and its progression were investigated in a study of HIV-positive patients, exposed but uninfected (EU) subjects, and healthy control subjects, all lacking CCR5 Delta 32 homozygosity. SDF1-3'A homozygosity was associated with low plasma SDF-1 levels in uninfected persons and was not related to long-term nonprogression. HIV-1 infection involved increased plasma SDF-1 levels, which were not attributable to any kind of chronic viral infection, because all EU hemophiliacs were hepatitis C virus-positive but had normal SDF-1 levels. High plasma SDF-1 levels and low CXCR4 expression on T lymphocytes was associated with long-term nonprogression, whereas in advancing disease expression of CXCR4 increased, accompanied by a decrease in plasma SDF-1 during the more advanced stages of HIV-1 infection. EU subjects with sexual exposure to HIV-1, but not EU hemophiliacs, showed an underpresentation of SDF1-3'A allele frequency, which was coupled with high plasma SDF-1 levels and low CXCR4 expression.
Soriano
Alex
A
Institut Clínic d'Infeccions i Immunologia, Hospital Clínic Universitari, Barcelona, Spain.
Martínez
Catalina
C
García
Felipe
F
Plana
Montserrat
M
Palou
Eduard
E
Lejeune
Marylène
M
Aróstegui
Juan I
JI
De Lazzari
Elisa
E
Rodriguez
Carmen
C
Barrasa
Alicia
A
Lorenzo
José I
JI
Alcamí
José
J
del Romero
Jorge
J
Miró
José M
JM
Gatell
José M
JM
Gallart
Teresa
T
D000328:Adult; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000097:blood* / Q000235:genetics; D018450:Disease Progression; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D020276:HIV Long-Term Survivors; D006679:HIV Seropositivity / Q000175:diagnosis; D015497:HIV-1 / Q000502:physiology; D006720:Homozygote; D006801:Humans; D008297:Male; D019718:Receptors, CXCR4 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D014779:Virus Replication / Q000276:immunology
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D019718:Receptors, CXCR4