title: Immunologic abnormalities and surgical experiences in recurrent facial nerve paralysis.
abstract: OBJECTIVE
  To document immunologic findings in patients with recurrent facial paralysis (RFP) and to compare the results of the surgery with the results of medical treatment.
  
  
  METHODS
  Retrospective case review.
  
  
  METHODS
  Tertiary care referral center.
  
  
  METHODS
  Nine patients with RFP were reviewed.
  
  
  METHODS
  Patients underwent nonspecific antibody detection, protein electrophoresis (in blood and cerebrospinal fluid [CSF]) and oligoclonal band determination for immunoglobulin G, A, and M (in CSF). The extended subtotal facial nerve decompression via the transmastoid and transattic route was performed in four patients. Five patients received medical treatment only (steroids, vitamin B).
  
  
  RESULTS
  Two patients had the complete and four patients had the oligosymptomatic form of Melkersson-Rosenthal syndrome. The other three patients were diagnosed with idiopathic RFP. Serum immunoglobulin G was high in seven of nine patients (77%). CSF protein electrophoresis demonstrated an elevated albumin fraction in six of nine patients (66%). CSF immunoglobulin G was high in four of nine patients (44%). The oligoclonal band in CSF was negative in all patients. Mean follow-up time was 5.2 +/- 2.6 years and 3 +/- 1.5 years for surgically treated patients and medically treated patients, respectively. None of the patients who underwent the surgery demonstrated recurrence. Although marked recovery was observed in patients who had received medical treatment, three of them had recurrence during the follow-up period.
  
  
  CONCLUSIONS
  Serologic test results have demonstrated immune system involvement in cases of idiopathic RFP and in cases of Melkersson-Rosenthal syndrome, providing no distinction between the two. There was no sign substantiating local antibody production in CSF, which implies that the elevated antibodies in CSF were peripheral in origin. Although the serologic test results were not conclusive for a specific diagnosis, they support an immune-mediated pathogenesis. Despite the small number of patients who underwent the extended transmastoid facial nerve decompression, our follow-up data were suggestive for the prevention of recurrences.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Gulhane Medical School, Etik-Ankara, Turkey. syetiser@yahoo.com
authors.forename: Sertac
authors.initials: S
authors.lastname: Yetiser
authors.forename: Bulent
authors.initials: B
authors.lastname: Satar
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kazkayasi
mesh_terms: D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid; D001301:Audiometry, Pure-Tone; D005158:Facial Paralysis / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D008297:Male; D012008:Recurrence; D012720:Severity of Illness Index
chemical_list: D000418:Albumins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M