title: Estimation of growth inhibition by copper and cadmium in heavy metal tolerant actinomycetes.
abstract: A new isothermic model of actinomycetes growth in presence of toxic concentrations of Cd(2+) and Cu(2+) is described. Microbial growth inhibition, displayed as a decrease of biomass, can be correlated with the increase of cadmium(II) or copper(II) concentration in the medium. The reciprocal dry biomass against metal concentration showed a linear correlation higher than 0.9 in tested strains. The mathematical model can be useful to predict the behavior of actinomycetes at inhibitory concentrations of copper(II) and cadmium(II) in large screening procedures.
authors.affiliation: PROIMI, CONICET, PJE Bel Grano y Caseros, 4000 San Miguel de Tucumán, Argentina. mjamoroso@ciudad.com.ar
authors.forename: María J
authors.initials: MJ
authors.lastname: Amoroso
authors.forename: Guillermo
authors.initials: G
authors.lastname: Oliver
authors.forename: Guillermo R
authors.initials: GR
authors.lastname: Castro
mesh_terms: D000192:Actinomycetales / Q000187:drug effects* / Q000254:growth & development*; D002104:Cadmium / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D008433:Mathematics; D019216:Metals, Heavy / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008954:Models, Biological
chemical_list: D003470:Culture Media; D019216:Metals, Heavy; D002104:Cadmium; D003300:Copper