title: Macrophage-enhanced germination of Bacillus anthracis endospores requires gerS.
abstract: Germination of Bacillus anthracis Sterne and plasmidless Delta-Sterne endospores was dramatically enhanced in RAW264.7 macrophage-like cells, while germination of nonpathogenic Bacillus endospores was not. Elimination of gerS, a germinant receptor locus, caused a complete loss of cell-enhanced germination, implicating gerS in the breaking of endospore dormancy in vivo.
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
authors.forename: John A W
authors.initials: JA
authors.lastname: Ireland
authors.forename: Philip C
authors.initials: PC
authors.lastname: Hanna
mesh_terms: D000818:Animals; D001408:Bacillus anthracis / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D002460:Cell Line; D003470:Culture Media; D005798:Genes, Bacterial; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D010587:Phagocytosis; D013171:Spores, Bacterial / Q000235:genetics / Q000502:physiology; D014774:Virulence / Q000235:genetics / Q000502:physiology
chemical_list: D003470:Culture Media