title: [Long-term follow-up of the health status of opiate abusers treated with methadone--pilot study].
abstract: BACKGROUND
  Examination of the health status of patients abusing opiates can be substantiated by their high morbidity. The aim of the work was to describe the actual health status and the extent and seriousness of the affliction before the substitution therapy with opioid receptors agonist--methadone.
  
  
  RESULTS
  The group of drug abusers consisted of 101 persons (average age was 28.5 years, within the range of 20 to 47 years, 77 men and 24 women). Among the pathological findings, values of the levels of hepatic enzymes ALT, AST (35 and 31%), GMT (9%), low haemoglobin levels (24%) and elevated values of IgM (38%) and CRP (25%) belonged to the most frequent ones. Because of the simultaneously positive tests for hepatitis (C and B, 70% and 61%), the alteration is fully obvious. Low testosterone levels in males (63%) indicate the dysfunction of the hypothalamus-hypophysis-gonadas axis. Increased values of thyroxin (14%), P (20%) and atherogenity index (19%) remain unexplained. Several other laboratory-biochemical parameters remained within the physiological range. Imaging methods revealed hepatomegaly in 28% and splenomegaly in 27%, echotexture indicating steatosis was found in 15% of studied persons.
  
  
  CONCLUSIONS
  In chronic drug abusers before the onset of the substitution therapy, it is possible to expect frequent alterations, namely that of hepatic functions, positive test for hepatitis B and C, alteration of immunoglobulines level and testosterone deficits (in males).
authors.affiliation: III. interní klinika 1. LF UK a VFN, Praha. wil@volny.cz
authors.forename: H
authors.initials: H
authors.lastname: Wilczek
authors.forename: Z
authors.initials: Z
authors.lastname: Veselý
authors.forename: J
authors.initials: J
authors.lastname: Presl
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D005260:Female; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006525:Hepatitis, Viral, Human / Q000150:complications; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000097:blood / Q000150:complications / Q000534:rehabilitation*
chemical_list: D008691:Methadone