[Chemically induced (streptozotocin-alloxan) diabetes mellitus in dogs].
To evaluate the efficiency and toxic and side effect of the combined chemical inducer for Type I diabetes mellitus, Type I diabetes in 9 adult dogs were induced with alloxan(50 mg.kg-1) and streptozotocin (30 mg.kg-1) with vein injection. After 7-14 days, the blood glucose of 5 male dogs was kept on high levels [mean value was (22.7 +/- 3.2) mmol.L-1], exogenous insulin was (21.4 +/- 2.4) U.day-1. Three female dogs died in 7 days after they had been injected with the combined inducers. Alloxan-streptozotocin combination administration reduced the dosage of each drug, and decreased the toxic and side effect of each drug. The results suggest that this method has a high rate of success to induce Type I diabetes male dogs.
Liu
S
S
Department of Radiology, Third Affiliated Hospital, Hunan Medical University, Changsha 410013.
Wang
W
W
Luo
X M
XM
Ye
B
B
D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008297:Male; D013311:Streptozocin
D013311:Streptozocin; D000496:Alloxan