Increased uptake of technetium-99m-hexamethylpropyleneamine oxime related to primary leptomeningeal melanoma.
We present an autopsy case of primary leptomeningeal melanoma visualized with technetium-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) single photon emission CT (SPECT) of the brain. Increased uptake of Tc-99m-HMPAO coincided with leptomeningeal enhancement on MR images and with the tumor location of the autopsy findings. It was thought that Tc-99m-HMPAO could correlate closely with melanoma. Tc-99m-HMPAO SPECT clearly showed primary leptomeningeal melanoma and severe hypoperfusion induced by intracranial hypertension and tumor proliferation.
Sagiuchi
Takao
T
Department of Radiology, Kitasato University School of Medicine, Kanagawa, Japan.
Ishii
Katsumi
K
Utsuki
Satoshi
S
Asano
Yuuji
Y
Tsukahara
Shinya
S
Kan
Shinichi
S
Fujii
Kiyotaka
K
Hayakawa
Kazushige
K
D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D019690:Technetium Tc 99m Exametazime