title: Recent advances in inducible expression in transgenic mice.
abstract: In order to accurately analyze gene function in transgenic mice, as well as to generate credible murine models of human diseases, the ability to regulate temporal- and spatial-specific expression of target genes is absolutely critical. Pioneering work in inducible transgenics, begun in the 1980s and continuing to the present, has led to the development of a variety of different inducible systems dedicated to this goal, the shared basis of which is the accurate conditional expression of a given transgene. Recent advances in inducible transgene expression in mice are discussed.
authors.affiliation: Department of Developmental and Molecular Biology, The Albert Einstein Cancer Center, Division of Hormone-Dependent Tumor Biology, Albert Einstein College of Medicine, Bronkx, NY 10461, USA. albanese@aecom.yu.edu
authors.forename: Chris
authors.initials: C
authors.lastname: Albanese
authors.forename: James
authors.initials: J
authors.lastname: Hulit
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sakamaki
authors.forename: Richard G
authors.initials: RG
authors.lastname: Pestell
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D004440:Ecdysone / Q000378:metabolism*; D004441:Ecdysterone / Q000031:analogs & derivatives / Q000494:pharmacology; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D005821:Genetic Techniques; D008024:Ligands; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D013629:Tamoxifen / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D018931:Antineoplastic Agents, Hormonal; D018076:DNA, Complementary; D008024:Ligands; D013629:Tamoxifen; D004440:Ecdysone; D004441:Ecdysterone; C008999:ponasterone A; D013752:Tetracycline