Signalling shortcuts: cell-surface receptors in the nucleus?
Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there and what function do they serve in this location? Recent advances have provided tantalizing hints to the answers to these questions, and hold the key to identifying a new mode of signal transduction.
Wells
Alan
A
Department of Pathology, 713 Scaife, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. wellsa@msx.upmc.edu
Marti
Ulrich
U
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
D008024:Ligands; D011956:Receptors, Cell Surface; D066246:ErbB Receptors