Structure Prediction and Analyzing of the Molecular Chaperone TCP1.
An improved Chou and Fasman method and the Robson method from Prosis software were applied to four TCP1s and five homologous proteins. The predictive results showed that there may exist two structural domains in TCPI with a "hinge region" between them, suggesting that the two structural domains may be alpha/beta barrels. The putative ATP-binding domain, whose motif centres around the absolute conserved GDGTT sequence at position 87-91 in TCP1Hu, was found to be a coil region in the predictive results.
Zhou
Ren-Zhong
RZ
Sichuan Industrial Institute of Antibiotics of the State Pharmaceutical Administration of China, Chengdu 610051, China.
Yuan
Qin-Sheng
QS