Electrical stimulation as an adjunct to spinal fusion: a meta-analysis of controlled clinical trials.
This study was a meta-analysis to examine whether electrical stimulation has a specific effect on spinal fusion. Little evidence exists on the efficacy of electrical stimulation for improving fusion rate of spinal fusion surgery. Using MEDLINE (1966-2000) and EMBASE (1985-1999), a search for articles was carried out using the Medical Subject Headings: (1) electric stimulation or electromagnetic fields, (2) spinal fusion, (3) controlled or clinical trial, and (4) human. Data were extracted from all the hit articles and additionally collected from appropriate journal lists. A total of five randomized controlled trials (RCT) on bones assessing healing of spinal fusion were identified and scored on methodological quality. All the identified studies reported positive findings, but the quality score of each trial showed wide flaws. Because of relatively homogenous subjects who had spine fusion and radiographic assessment from these studies, pooling of the data was able to be performed. Excluding one trial with the lowest score, the combined results of four trials, whose major endpoints were the success rate of the fusion, revealed a statistically significant effect of electrical stimulation with various techniques, but the selected trials still showed wide variation in view of stimulation modalities and treatment protocol. The pooled result of the studies in this review revealed the efficacy of electrical stimulation based on proved methodological quality. As problems on therapeutic modality and protocol remain, there is a further need for improvement in design to constitute acceptable proof and to establish treatment programs that better demonstrate electrical stimulation effects on spinal fusion.
Akai
Masami
M
Department of Motor Dysfunction, Research Institute of National Rehabilitation Center, 4-1 Namiki, Tokorozawa, Saitama, Japan. akai@rehab.go.jp
Kawashima
Noritaka
N
Kimura
Toshitaka
T
Hayashi
Kunihiko
K
D003131:Combined Modality Therapy; D018849:Controlled Clinical Trials as Topic; D016206:Databases, Bibliographic; D004599:Electric Stimulation Therapy; D004574:Electromagnetic Fields; D006801:Humans; D016239:MEDLINE; D013123:Spinal Fusion / Q000379:methods*; D016896:Treatment Outcome