title: Immature-like astrocytes are associated with dentate granule cell migration in human temporal lobe epilepsy.
abstract: In human temporal lobe epilepsy, a dispersion of dentate granule cells is frequently described in adults who had an early risk factor. To elucidate the role of glia in this phenomenon, we investigated neuronal dispersion, astrocyte organization and expression of intermediate filaments of mature and immature astrocytes (i.e. glial fibrillary acidic protein (GFAP) and vimentin, respectively) in seven subjects with early febrile seizures (F(+)) and five subjects with other etiologies than febrile seizures (F(-)). Compared to F(-) patients, a majority of F(+) subjects showed neuronal dispersion and vimentin expression in radial glia. However, in two patients with the maximal dispersion, radial processes expressed only GFAP. We suggest that granule cell migration that occurs in adult epileptic focus results from the transient occurrence of immature-like glia throughout the granular layer.
authors.affiliation: UPR CNRS 9023, CCIPE, Montpellier, France. a-crespel@chu-montpellier.fr
authors.forename: Arielle
authors.initials: A
authors.lastname: Crespel
authors.forename: Philippe
authors.initials: P
authors.lastname: Coubes
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Rousset
authors.forename: Gérard
authors.initials: G
authors.lastname: Alonso
authors.forename: Joël
authors.initials: J
authors.lastname: Bockaert
authors.forename: Michel
authors.initials: M
authors.lastname: Baldy-Moulinier
authors.forename: Mireille
authors.initials: M
authors.lastname: Lerner-Natoli
mesh_terms: D000328:Adult; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D002465:Cell Movement; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D014746:Vimentin / Q000096:biosynthesis
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin