title: Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence.
abstract: In this 12-week double-blind placebo-controlled trial of methylphenidate (MTP) versus placebo in 48 cocaine-dependent attention-deficit/hyperactivity disorder (ADHD) adults, the authors sought to determine whether MTP would be safe, control ADHD symptoms, and affect cocaine use. Efficacy indexes revealed significantly greater ADHD symptom relief in the MTP group. There were no group differences in self-reported cocaine use, urinalysis results, or cocaine craving. Because of the relatively small sample size, the results are preliminary. However, we found that MTP improved subjective reports of ADHD symptoms and did not worsen cocaine use while participants were in treatment.
authors.affiliation: Department of Internal Medicine, Wayne State University, USA. hschubiner@mindspring.com
authors.forename: Howard
authors.initials: H
authors.lastname: Schubiner
authors.forename: Karen K
authors.initials: KK
authors.lastname: Saules
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Arfken
authors.forename: Chris-Ellyn
authors.initials: CE
authors.lastname: Johanson
authors.forename: Charles R
authors.initials: CR
authors.lastname: Schuster
authors.forename: Nancy
authors.initials: N
authors.lastname: Lockhart
authors.forename: Ann
authors.initials: A
authors.lastname: Edwards
authors.forename: Judy
authors.initials: J
authors.lastname: Donlin
authors.forename: Eric
authors.initials: E
authors.lastname: Pihlgren
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use*; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D015897:Comorbidity; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010389:Pemoline / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D010389:Pemoline