Dodeca(carboranyl)-substituted closomers: toward unimolecular nanoparticles as delivery vehicles for BNCT.
The syntheses of the dodeca(carboranyl)-substituted closomers, dodeca[7-(2-methyl-1,2-dicarba-closo-dodecaboran-1-yl)heptanoate]-closo- dodecaborate(2-) and dodeca[7-(8-methyl-7,8-dicarba-nido-dodecaboran-7-yl)- heptanoate]-closo-dodecaborate(14-) are reported. These boron-rich, unimolecular nanospheres possess great potential for future use as drug-delivery platforms for boron neutron capture therapy (BNCT).
Thomas
J
J
Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Hawthorne
M F
MF
D001896:Boron Compounds / Q000737:chemistry; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D046911:Macromolecular Substances; D008958:Models, Molecular; D036103:Nanotechnology / Q000379:methods
D001896:Boron Compounds; D046911:Macromolecular Substances; C467818:dodeca(7-(2-methyl-1,2-dicarba-closo-dodecaboran-1-yl)heptanoate)-closo- dodecaborate; C467819:dodeca(7-(8-methyl-7,8-dicarba-nido-dodecaboran-7-yl)- heptanoate)-closo-dodecaborate