Synthesis and DNA-binding properties of dinuclear platinum(II)-amine complexes of 1,7-dicarba-closo-dodecaborane(12).
The first examples of platinum(II)-amine complexes containing a dicarba-closo-dodecaborane(12) (carborane) moiety are described; preliminary in vitro DNA-binding experiments indicate that the complexes are capable of targetting plasmid DNA.
Woodhouse
S L
SL
Department of Chemistry, University of Adelaide, Adelaide 5005, Australia.
Rendina
L M
LM
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism*; D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism*; D016754:Boron Neutron Capture Therapy; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000378:metabolism*; D010957:Plasmids
D000970:Antineoplastic Agents; D001896:Boron Compounds; D003432:Cross-Linking Reagents; D009944:Organoplatinum Compounds; D004247:DNA