Do fibrinolytic proteins of human bile derive exclusively from gall bladder?
BACKGROUND
In this study we addressed the issue of whether fibrinolytic proteins are presented in gall bladder bile only or in choledochus bile as well.


METHODS
Gall bladder bile was obtained from 20 patients (Group I) undergoing laparoscopic cholecystectomy. Bile from common bile duct was aspirated after insertion Kehr drainage from 9 patients (Group II). The concentrations of t-PA, u-PA, PAI-1 and PAI-2 were measured by ELISA.


RESULTS
We have shown that in cholecystectomized patients fibrinolytic proteins can be detected in bile both from gall bladder and from choledochus. Mean concentrations of t-PA, u-PA, PAI-1 were lower in Group II (5.69 ng/ml vs 15.7; 0.46 ng/ml vs 0.7; 16.82 ng/ml vs 26.16 ng/ml) or nearly equal for PAI-2 (343.53 ng/ml vs 341.02). All differences were insignificant (p > 0.05).


CONCLUSIONS
Based on these results we concluded that the entire biliary tree produces the fibrinolytic proteins thus this production is not restricted to the gall bladder as it was earlier reported [1].
Gil
D
D
Department of Internal Medicine, Silesian Medical University, St. Barbara's District Hospital, Plac Medyków 1, 41-200 Sosnowiec, Poland.
Michalski
A
A
Kondera-Anasz
Z
Z
Gil
B
B
Starzewski
J
J
Gonciarz
Z
Z
D001646:Bile / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005704:Gallbladder / Q000378:metabolism*; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D017396:Plasminogen Activator Inhibitor 2 / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D017395:Plasminogen Activator Inhibitor 1; D017396:Plasminogen Activator Inhibitor 2; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator