Tetramethylpyrazine protects mice against thioacetamide-induced acute hepatotoxicity.
In this study, the intraperitoneal administration of 1 mg/kg thioacetamide (TAA) produced hepatotoxicity in mice. The increase in serum SGOT and SGPT produced at 24 h by this regimen was decreased in a dose-dependent manner by coadministration of tetramethylpyrazine (TMP; 10, 25 and 50 mg/kg). A rise in serum interleukin-2 was similarly prevented. Increased concentrations of malondialdehyde (MDA) generated in vitro in liver homogenates prepared from TAA-treated mice were decreased by TMP treatments. The increase in MDA produced by TAA was also prevented by in vitro addition of TMP to liver homogenates. These results suggest that part of the hepatocellular injury induced by TAA is mediated by oxidative stress caused by the action of cytokines through lipid peroxidation. TMP appears to act by preventing lipid peroxidation.
So
Edmund C
EC
Department of Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan, ROC.
Wong
Kar-Lok
KL
Huang
Tian-Chyuan
TC
Tasi
Sheng-Chou C
SC
Liu
Chi-Feng
CF
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002851:Chromatography, High Pressure Liquid; D007376:Interleukin-2 / Q000097:blood; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011719:Pyrazines / Q000494:pharmacology*; D013853:Thioacetamide / Q000633:toxicity*
D007376:Interleukin-2; D011719:Pyrazines; D013853:Thioacetamide; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C017953:tetramethylpyrazine