Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
The present study describes the phytochemical analysis and analgesic activity of Curcuma zedoaria rhizomes grown in Brazil. The results showed that the hydroalcoholic extract, fractions, specially dichloromethane, and a pure compound, denoted as curcumenol (1), exhibited potent and dose-related analgesic activity when evaluated in several models of pain in mice, including writhing, formalin and capsaicin. Compound (1), which seems to be the main active principle from this plant, presented promising analgesic effects, being several times more potent than different reference drugs evaluated in the same experimental models. The calculated ID50 values (micromol/kg, i.p) were 22 and 12 when evaluated in writhing and capsaicin tests, respectively, and 29 micromol/kg in relation to the second phase of the formalin model. The lack of effect in the hot plate test suggests that (1) act by a mechanism which do not involves the participation of the opioid system. The phytochemical analysis indicated that the chemical composition of the plant grown in Brazil is similar to that grown in other countries. The results confirm and justify the popular use of this plant for the treatment of dolorous processes.
Navarro
D de Fátima
Dde F
Departamento de Farmácia, Universidade Estadual de Ponta Grossa, PR, Brazil.
de Souza
M M
MM
Neto
R A
RA
Golin
V
V
Niero
R
R
Yunes
R A
RA
Delle Monache
F
F
Cechinel Filho
V
V
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001938:Brazil; D030024:Curcuma / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
D000700:Analgesics; D010936:Plant Extracts