title: The Escherichia coli metD locus encodes an ABC transporter which includes Abc (MetN), YaeE (MetI), and YaeC (MetQ).
abstract: We report that the genes abc, yaeC, and yaeE comprise metD, an Escherichia coli locus encoding a DL-methionine uptake system. MetD is an ABC transporter with Abc the ATPase, YaeE the permease, and YaeC the likely substrate binding protein. Expression of these genes is regulated by L-methionine and MetJ, a common repressor of the methionine regulon. We propose to rename abc, yaeE, and yaeC as metN, metI, and metQ, respectively.
authors.affiliation: University of Edinburgh, Institute for Cell and Molecular Biology, Edinburgh EH9 3JR, Scotland.
authors.forename: Christophe
authors.initials: C
authors.lastname: Merlin
authors.forename: Gregory
authors.initials: G
authors.lastname: Gardiner
authors.forename: Sylvain
authors.initials: S
authors.lastname: Durand
authors.forename: Millicent
authors.initials: M
authors.lastname: Masters
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D026905:Amino Acid Transport Systems / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D014158:Transcription, Genetic
chemical_list: D018528:ATP-Binding Cassette Transporters; D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C466429:MetI protein, E coli; C466430:MetQ protein, E coli; D008715:Methionine; D000251:Adenosine Triphosphatases; C466428:MetN protein, E coli