Metal complexation of thiacrown ether macrocycles by electrospray ionization mass spectrometry.
In the present study, electrospray ionization mass spectrometry is used to evaluate the metal-binding selectivities of an array of novel caged macrocycles for mercury(II), lead(II), cadmium(II), and zinc(II) ions. In homogeneous methanol/chloroform solutions as well as extractions of metals from aqueous solution by macrocycles in chloroform, it is found that the type of heteroatom (S, O, N), cavity size, and presence of other substituents influence the metal selectivities. Several of the macrocycles in this study bind mercury ion very selectively and efficiently in the presence of many other metal ions and have an avidity toward mercury that was tunable by the size and combination of heteroatoms in the macrocycle ring and the number of cage groups attached. The extraction mechanism was further investigated by determining the variation in extraction selectivity as a function of the counterions of the mercury salts.
Williams
Sheldon M
SM
Department of Chemistry and Biochemistry, University of Texas at Austin, 78712, USA.
Brodbelt
Jennifer S
JS
Marchand
Alan P
AP
Cal
Dariusz
D
Mlinaric-Majerski
Kata
K
D002104:Cadmium / Q000737:chemistry / Q000302:isolation & purification; D004785:Environmental Pollutants / Q000302:isolation & purification; D004988:Ethers, Cyclic / Q000032:analysis / Q000737:chemistry*; D007854:Lead / Q000737:chemistry / Q000302:isolation & purification; D008628:Mercury / Q000737:chemistry / Q000302:isolation & purification; D019216:Metals, Heavy / Q000737:chemistry / Q000302:isolation & purification*; D009942:Organometallic Compounds / Q000032:analysis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D015032:Zinc / Q000737:chemistry / Q000302:isolation & purification
D004785:Environmental Pollutants; D004988:Ethers, Cyclic; D019216:Metals, Heavy; D009942:Organometallic Compounds; D002104:Cadmium; D007854:Lead; D008628:Mercury; D015032:Zinc