title: Mapping at glomerular resolution: fMRI of rat olfactory bulb.
abstract: The rat olfactory bulb contains approximately 2000 functional units called glomeruli which are used to recognize specific characteristics of odorants. Activity localization of individual glomerulae ( approximately 0.002 microL) has important consequences for understanding mechanisms in olfactory information encoding. High-resolution functional MRI (fMRI) data from the rat olfactory bulb are presented using the blood oxygenation level dependent (BOLD) method at 7 T. Either individual or clusters of fMRI voxels suggestive of activity in the olfactory nerve and glomerular layers were reproducibly detected with repeated 2-min exposures of iso-amyl acetate at spatial resolution of 0.001-0.003 microL. The importance of glomerular clustering for olfaction and the implications of BOLD mapping with even higher spatial resolution (i.e., <<0.001 microL voxels) are discussed. High-resolution in vivo mapping of the rat olfactory bulb with fMRI at high magnetic field promises to provide novel data for understanding olfaction.
authors.affiliation: Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut 06510, USA.
authors.forename: Ikuhiro
authors.initials: I
authors.lastname: Kida
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Xu
authors.forename: Robert G
authors.initials: RG
authors.lastname: Shulman
authors.forename: Fahmeed
authors.initials: F
authors.lastname: Hyder
mesh_terms: D000818:Animals; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009812:Odorants; D009830:Olfactory Bulb / Q000033:anatomy & histology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012903:Smell / Q000502:physiology*