Primary cutaneous cryptococcosis due to Cryptococcus neoformans var. gattii serotype B, in an immunocompetent patient.
The authors report a male patient, a seller with no detected immunosuppression, with an extensive ulcerated skin lesion localized on the left forearm, caused by Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole was successful. A review of the literature showed the rarity of this localization in HIV-negative patients. In contrast, skin lesions frequently occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans serotype A predominating as the etiological agent. In this paper, the pathogenicity of C. neoformans to skin lesions in patients immunocompromised or not, is discussed, showing the efficacy of fluconazole for the treatment of these processes.
Lacaz
Carlos da Silva
Cda S
Laboratório de Micologia Médica, Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil.
Heins-Vaccari
Elisabeth Maria
EM
Hernandez-Arriagada
Giovanna L
GL
Martins
Eduardo Lacaz
EL
Prearo
Célia A L
CA
Corim
Simone Miwa
SM
Martins
Marilena dos Anjos
Mdos A
D000368:Aged; D003453:Cryptococcosis / Q000382:microbiology*; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D003881:Dermatomycoses / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male