title: Role of transbronchial needle aspiration in patients receiving mechanical ventilation.
abstract: OBJECTIVE
  s: To evaluate the diagnostic accuracy and safety of transbronchial needle aspiration (TBNA) in patients receiving mechanical ventilation in the ICU.
  
  
  METHODS
  Retrospective review of all patients in the medical and surgical ICUs from February 1999 to July 2001 who underwent TBNA while receiving mechanical ventilation.
  
  
  RESULTS
  A total of eight histology (19 gauge) and eight cytology (22 gauge) TBNAs were performed on eight patients (four men and four women). TBNA yielded a definitive pathologic diagnosis in five of eight patients (62.5%). Diagnoses were posttransplantation lymphoproliferative disorder, large cell carcinoma, poorly differentiated non-small cell carcinoma, squamous cell carcinoma, and adenocarcinoma. Among patients with negative TBNA results (n = 3), two patients underwent mediastinoscopy. Results of mediastinoscopy were non-small cell carcinoma and inflamed tissue. TBNA led to management changes in five of these patients. Excluding one patient in whom a negative TBNA result could not be further confirmed, TBNA yielded a sensitivity of 83%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 50%. The overall accuracy of the procedure was 75%. There were no complications following any of the TBNAs.
  
  
  CONCLUSIONS
  In this small group of patients, TBNA was safe and had a high diagnostic accuracy in selected patients receiving mechanical ventilation in the ICU.
authors.affiliation: Department of Pulmonary and Critical Care, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: Shekhar
authors.initials: S
authors.lastname: Ghamande
authors.forename: Albert
authors.initials: A
authors.lastname: Rafanan
authors.forename: Raed
authors.initials: R
authors.lastname: Dweik
authors.forename: Alejandro C
authors.initials: AC
authors.lastname: Arroliga
authors.forename: Atul C
authors.initials: AC
authors.lastname: Mehta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001999:Bronchoscopy; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008481:Mediastinoscopy; D008875:Middle Aged; D011237:Predictive Value of Tests; D012121:Respiration, Artificial; D012189:Retrospective Studies