[The expression of p42/p44MAPK and cyclin D1 protein and their relationship in Hodgkin's disease].
The expressions of p42/44 mitogen-activated protein kinase(p42/p44MAPK) and cyclin D1 protein were detected by SP immunohistochemical technique in 40 cases of Hodgkin's disease(HD) and 13 cases of reactive hyperplasia(RH). The results showed that p42/p44MAPK and cyclin D1 protein were both overexpressed in RS/H cells of HD(positive rates were 72.5% and 70% respectively), and their positive rates were positively correlated(P < 0.01). The data suggest that MAPK cascades signal transduction may play an important role in genesis of HD. MAPK may induce overexpression of cyclin D1 protein and result in persistent proliferation and progression of RS/H cells.
Li
Y N
YN
Department of Pathology, Hunan Medical University, Changsha 410078.
Zheng
H
H
Jiang
H Y
HY
Feng
D Y
DY
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D019938:Cyclin D1 / Q000096:biosynthesis*; D005260:Female; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1 / Q000096:biosynthesis*; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000096:biosynthesis*; D019310:Pseudolymphoma / Q000378:metabolism; D016539:Reed-Sternberg Cells / Q000378:metabolism; D015398:Signal Transduction
D019938:Cyclin D1; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases