Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits.
Cholesterol is considered a risk factor in vascular dementia as well as in Alzheimer's disease. Several biochemical, epidemiological and genetic aspects established a correlation between cholesterol concentration and Alzheimer's disease. Microglia activation, astrocytosis with metallothionein-I-II overexpression, amyloid beta intraneuronal accumulation and a rare formation of amyloid beta extracellular positive deposits were the major immunohistochemical features observed in the brain of high cholesterol-fed animals. The relevance on the cholesterol metabolism in Alzheimer's disease pathogenesis is also discussed.
Zatta
Paolo
P
CNR Center on Metalloproteins, Department of Biology, University of Padova, Italy. zatta@cribi1.bio.unipd.it
Zambenedetti
Pamela
P
Stella
Maria Pia
MP
Licastro
Federico
F
D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000686:Amyloidosis / Q000473:pathology*; D000818:Animals; D001253:Astrocytes / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002791:Cholesterol, Dietary / Q000009:adverse effects; D005911:Gliosis / Q000473:pathology*; D007124:Immunoenzyme Techniques; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D009454:Neurofibrils / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology; D011817:Rabbits; D012016:Reference Values
D016229:Amyloid beta-Peptides; D002791:Cholesterol, Dietary; D008668:Metallothionein