title: Neurologic manifestations of iron deficiency in childhood.
abstract: Iron deficiency is a common disorder in pediatric patients. Although the most common manifestation is that of anemia, iron deficiency is frequently the source of a host of neurologic disorders presenting to general pediatric neurologic practices. These disorders include developmental delay, stroke, breath-holding episodes, pseudotumor cerebri, and cranial nerve palsies. Although frequent, the identification of iron deficiency as part of the differential diagnosis in these disorders is uncommon and frequently goes untreated. The purpose of the current review is to highlight what is understood regarding iron deficiency and it's underlying pathophysiology as it relates to the brain, and the association of iron deficiency with common neurologic pediatric disease.
authors.affiliation: Department of Pediatrics, University of Saskatchewan;, Saskatoon, Canada
authors.forename: Jerome Y
authors.initials: JY
authors.lastname: Yager
authors.forename: Dawn S
authors.initials: DS
authors.lastname: Hartfield
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000150:complications*; D001927:Brain Diseases / Q000209:etiology* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007223:Infant; D000090463:Iron Deficiencies; D010649:Phenylalanine / Q000378:metabolism; D011559:Pseudotumor Cerebri / Q000209:etiology / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D020521:Stroke / Q000209:etiology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D012701:Serotonin; D010649:Phenylalanine; D005680:gamma-Aminobutyric Acid; D004298:Dopamine