Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving.
We aimed to examine the relationship between central monoamine metabolites and craving cocaine in cocaine-dependent patients. Cerebrospinal fluid (CSF) monoamine metabolite concentrations were determined in 20 withdrawn cocaine-dependent patients. Patients also participated in a cue-elicited cocaine craving procedure. There were no significant relationships between cocaine craving scores and CSF concentrations of the dopamine metabolite, homovanillic acid, the serotonin metabolite, 5-hydroxyindoleacetic acid, or the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylglycol. CSF monoamine metabolite concentrations were not related to cocaine craving in withdrawn cocaine-dependent patients.
Roy
Alec
A
Psychiatry Service, Department of Veterans Affairs, New Jersey Healthcare System, East Orange 07018, USA. Alec.Roy@med.va.gov
Berman
Jeffrey
J
Gonzalez
Bienvenido
B
Roy
Monique
M
D000328:Adult; D003042:Cocaine / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000134:cerebrospinal fluid / Q000523:psychology / Q000534:rehabilitation*; D003463:Cues; D004298:Dopamine / Q000502:physiology; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D009042:Motivation; D009638:Norepinephrine / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D016320:Substance Abuse Treatment Centers; D013375:Substance Withdrawal Syndrome / Q000134:cerebrospinal fluid* / Q000523:psychology
D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D003042:Cocaine; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid