title: Ulcerative colitis in monozygotic twin sisters.
abstract: We present a rare occurrence of woman monozygotic twins with ulcerative colitis (UC). A 21-year-old woman came to our hospital because of diarrhea, abdominal pain and hematochezia. We diagnosed this case as proctitis type UC by endoscopic and histological findings. Six months later, her twin sister developed total colitis type UC. Both twins had HLA-A24, B52, DR2, and DQ1 serological types, and had DRB1*1502 DNA type, previously shown to be associated with UC. This case report suggested an association of genetic factor together with environmental factors in the etiology for UC.
authors.affiliation: Department of Gastroenterology, Hamamatsu Medical Center.
authors.forename: Moriya
authors.initials: M
authors.lastname: Iwaizumi
authors.forename: Masami
authors.initials: M
authors.lastname: Yamada
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Takehira
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hanajima
authors.forename: Gou
authors.initials: G
authors.lastname: Murohisa
authors.forename: Motoko
authors.initials: M
authors.lastname: Kawamura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Iwaoka
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Wada
authors.forename: Satoru
authors.initials: S
authors.lastname: Morita
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Kawata
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D004247:DNA / Q000235:genetics; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D012307:Risk Factors; D014430:Twins, Monozygotic
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA