Recent advances in inducible expression in transgenic mice.
In order to accurately analyze gene function in transgenic mice, as well as to generate credible murine models of human diseases, the ability to regulate temporal- and spatial-specific expression of target genes is absolutely critical. Pioneering work in inducible transgenics, begun in the 1980s and continuing to the present, has led to the development of a variety of different inducible systems dedicated to this goal, the shared basis of which is the accurate conditional expression of a given transgene. Recent advances in inducible transgene expression in mice are discussed.
Albanese
Chris
C
Department of Developmental and Molecular Biology, The Albert Einstein Cancer Center, Division of Hormone-Dependent Tumor Biology, Albert Einstein College of Medicine, Bronkx, NY 10461, USA. albanese@aecom.yu.edu
Hulit
James
J
Sakamaki
Toshiyuki
T
Pestell
Richard G
RG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D004440:Ecdysone / Q000378:metabolism*; D004441:Ecdysterone / Q000031:analogs & derivatives / Q000494:pharmacology; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D005821:Genetic Techniques; D008024:Ligands; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D013629:Tamoxifen / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D018931:Antineoplastic Agents, Hormonal; D018076:DNA, Complementary; D008024:Ligands; D013629:Tamoxifen; D004440:Ecdysone; D004441:Ecdysterone; C008999:ponasterone A; D013752:Tetracycline