Solid-phase synthesis of alkyl aryl ethers via the Ullmann condensation.
Alkyl aryl ether formation is a frequently employed reaction in organic synthesis. Ullmann condensation is an alternative method to the widely used Mitsunobu reaction and is very useful in situations where application of the Mitsunobu reaction is limited. By application of this reaction to solid-phase synthesis of a series of alkyl aryl ethers, reaction conditions (catalyst, solvent, temperature, time, etc.) for a sterically hindered class of alcohols were investigated and optimized. A range of aryl halides was used to explore the scope of the reaction in solid phase.
Xiao
Xiao-Yi
XY
Bristol-Myers Squibb Company, Experimental Station, E500-4206, Route 141 & Henry Clay Road, Wilmington, DE 19880-0500, USA. xiao-yi.xiao@syrrx.com
Li
Rongshi
R
Hurst
David
D
Zhuang
Hui
H
Shi
Shuhao
S
Czarnik
Anthony W
AW
Robichaud
Albert J
AJ
Wacker
Dean A
DA
Robertson
David W
DW