Effect of the aqueous extract of xiao-ban-xia-tang on gastric emptying in mice.
Gastric emptying effect of the aqueous extract of xiao-ban-xia-tang (XBXT) was investigated in mice. Mice with food deprived for 18 hours were orally administered a certain amount of test meal (ca. 0.8 g) equaling 0.8 ml in volume. The percentage of 0.8 g test meal remaining in the stomach after 20 minutes was estimated. It was shown that XBXT significantly antagonized dopamine- (0.56 mg/kg, i.p.), not atropine- (0.3 mg/kg, i.p.), induced gastric emptying inhibition. It also significantly restored metoclopramide-induced (8 mg/kg, p.o.) propulsion and potentiated methylneostigmine-induced (2 mg/kg, p.o.) gastric emptying enhancement. The aqueous extract of Pinellia ternata, but not that of Zingiber officinale showed an inhibitory activity on gastric emptying. The present results suggest that XBXT possesses a regulative effect on gastric motility.
Chen
Duo
D
Department of Pharmacology, Shenyang Pharmaceutical University Shenyang, People's Republic of China.
Wu
Chun Fu
CF
Huang
Li
L
Ning
Zhuo
Z
D000284:Administration, Oral; D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001285:Atropine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D020939:Zingiber officinale; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D051379:Mice; D009388:Neostigmine / Q000494:pharmacology; D008517:Phytotherapy; D030021:Pinellia; D018517:Plant Roots
D000932:Antiemetics; D004365:Drugs, Chinese Herbal; C473471:xiao-ban-xia-tang; D009388:Neostigmine; D001285:Atropine; D008787:Metoclopramide; D004298:Dopamine