RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease.
Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.
Bucciarelli
L G
LG
College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
Wendt
T
T
Rong
L
L
Lalla
E
E
Hofmann
M A
MA
Goova
M T
MT
Taguchi
A
A
Yan
S F
SF
Yan
S D
SD
Stern
D M
DM
Schmidt
A M
AM
D000544:Alzheimer Disease / Q000209:etiology; D000686:Amyloidosis / Q000209:etiology; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement; D002908:Chronic Disease; D003925:Diabetic Angiopathies / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D007136:Immunoglobulins / Q000145:classification; D007249:Inflammation / Q000209:etiology; D051379:Mice; D009369:Neoplasms / Q000209:etiology / Q000473:pathology; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D007136:Immunoglobulins; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic