title: A case of refractory hypothyroidism requiring daily intravenous thyroxine.
abstract: Most patients with hypothyroidism respond to administration of oral thyroxine at a maintenance dose of 50-175 micrograms/day. This is the first documented patient with post-operative hypothyroidism who required about 10 times the standard dose of thyroxine, and whose symptoms only resolved when intravenous thyroxine was administered daily. Our findings support the benefits of daily intravenous therapy with thyroxine in this case.
authors.affiliation: Department of Internal Medicine, Kouseiren Takaoka Hospital, Takaoka, Japan. nagaoka@quartz.ocn.ne.jp
authors.forename: T
authors.initials: T
authors.lastname: Nagaoka
authors.forename: H
authors.initials: H
authors.lastname: Miyakoshi
authors.forename: T
authors.initials: T
authors.lastname: Takamura
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Matsushita
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D007275:Injections, Intravenous; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine