A model complex of a possible intermediate in the mechanism of action of peptide deformylase: first example of an (N2S)zinc(II)-formate complex.
The synthesis and crystallographic characterization of a new (N2S)zinc-alkyl complex and (N2S)zinc-formate complex is described; the bonding mode of the formate complex has implications for the mechanism of action of the enzyme peptide deformylase.
Chang
S C
SC
Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Sommer
R D
RD
Rheingold
A L
AL
Goldberg
D P
DP
D000581:Amidohydrolases; D000626:Aminopeptidases / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005561:Formates / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D008667:Metalloproteins / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D015032:Zinc / Q000737:chemistry*
D005561:Formates; D008667:Metalloproteins; C030544:formic acid; D007501:Iron; D000626:Aminopeptidases; D000581:Amidohydrolases; C084507:peptide deformylase; D015032:Zinc