title: Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria.
abstract: By using current NCCLS broth microdilution methods, we found that gatifloxacin inhibited 90% of the isolates of the Mycobacterium fortuitum group at < or =0.12 micro g/ml and 90% of the Mycobacterium chelonae isolates at < or =4 micro g/ml. Gatifloxacin was generally fourfold more active than ciprofloxacin. We recommend that both gatifloxacin and ciprofloxacin be tested routinely against rapidly growing mycobacteria.
authors.affiliation: Department of Microbiology, University of Texas Health Center, Tyler 75708, USA. barbara.elliott@uthct.edu
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Brown-Elliott
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Wallace
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Crist
authors.forename: Linda
authors.initials: L
authors.lastname: Mann
authors.forename: Rebecca W
authors.initials: RW
authors.lastname: Wilson
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006801:Humans; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000145:classification / Q000187:drug effects* / Q000254:growth & development*; D016926:Mycobacterium chelonae / Q000145:classification / Q000187:drug effects / Q000254:growth & development; D019907:Mycobacterium fortuitum / Q000145:classification / Q000187:drug effects / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D000077734:Gatifloxacin