title: Infiltrations of Epstein-Barr virus-carrying cells in granular lymphocyte-proliferative disorders corresponding to chronic active Epstein-Barr virus infection.
abstract: A 21-year-old man with granular lymphocyte-proliferative disorders (GLPD) associated with chronic active Epstein-Barr virus (EBV) infection is described. Chromosomal analyses revealed several clonal abnormalities and two of them were mainly repetitious. High copy numbers of monoclonal EBV genome were also detected in the proliferative large granular lymphocytes (LGLs), indicating the monoclonal expansion of EBV-infected LGLs. The patient had an indolent course for several years, and there was no evidence of infiltrations of his bone marrow until the end stage. At autopsy, microscopic studies revealed marked infiltrations of LGL in the liver and spleen, and the infiltrating cells were NK-cell immunophenotype. The infiltrated LGLs showed latency I.
authors.affiliation: Department of Pediatrics, Kochi Medical School, Kochi, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Takechi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Maeda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hisakawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wakiguchi
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sonobe
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ohtsuki
mesh_terms: D000328:Adult; D001344:Autopsy; D002869:Chromosome Aberrations; D002908:Chronic Disease; D002999:Clone Cells / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000235:genetics / Q000821:virology*; D008297:Male; D009361:Neoplasm Invasiveness / Q000175:diagnosis / Q000473:pathology*