title: Frequency and severity of systemic disease in patients with subacute cutaneous lupus erythematosus.
abstract: OBJECTIVE
  To compare the frequency and severity of systemic disease in patients with subacute cutaneous lupus erythematosus (SCLE) followed up in a dermatology practice vs patients with systemic lupus erythematosus (SLE) followed up in a rheumatology practice.
  
  
  METHODS
  Case-control comparison of patients matched for age, sex, and ethnicity.
  
  
  METHODS
  University-affiliated dermatology and rheumatology practices.
  
  
  METHODS
  Seventy-six patients with SCLE were compared with 24 patients with SLE.
  
  
  METHODS
  All medical records were reviewed and the patients were interviewed.
  
  
  METHODS
  Systemic and serologic findings were compared between patients with SCLE and those with SLE.
  
  
  RESULTS
  Hematologic disorders were present in 6 patients (8%) with SCLE and in 13 patients (54%) with SLE (P<.001). Serositis was present in 1 patient (1%) with SCLE and in 3 patients (12%) with SLE (P =.04). Renal involvement was present in 12 patients (16%) with SCLE and in 6 patients (25%) with SLE (P =.36). Antinuclear antibodies were found in 52 patients (68%) with SCLE compared with 23 patients (96%) with SLE (P =.006). Anti-Ro antibodies were found in 37 patients (49%) with SCLE compared with 10 patients (42%) with SLE (P =.64). Other serologic abnormalities (anti-native DNA, anti-Sm antibody, or anti-U(1)RNP) were present in 6 patients (8%) with SCLE compared with 15 patients (62%) with SLE (P<.001). Photosensitivity was present in 65 patients (86%) with SCLE, compared with 11 patients (46%) with SLE (P<.001).
  
  
  CONCLUSIONS
  This analysis reveals a dissimilar frequency of internal organ involvement between patients with SCLE and SLE. Renal disease was similar in frequency and severity, and documented central nervous system involvement was rare in both groups.
authors.affiliation: Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA. jefca@aol.com
authors.forename: Dana R
authors.initials: DR
authors.lastname: Black
authors.forename: Carlton A
authors.initials: CA
authors.lastname: Hornung
authors.forename: Paul D
authors.initials: PD
authors.lastname: Schneider
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Callen
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011336:Probability; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution