A new synthesis of Neu5Ac from D-glucono-delta-lactone.
A new route to Neu5Ac methyl ester (23) with a readily available sugar D-glucono-delta-lactone as starting material has been developed. A diastereoselective propargylation of alpha-acetamino aldehyde and a subsequent KMnO(4) oxidation of the terminal alkyne served as the key steps.
Liu
Ke-Gang
KG
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, China.
Yan
Shi
S
Wu
Yu-Lin
YL
Yao
Zhu-Jun
ZJ