Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.
Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.
Duda
John E
JE
Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Giasson
Benoit I
BI
Mabon
Meghann E
ME
Lee
Virginia M-Y
VM
Trojanowski
John Q
JQ
D000911:Antibodies, Monoclonal; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D020961:Lewy Body Disease / Q000378:metabolism* / Q000473:pathology*; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D009566:Nitrates / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D051843:Synucleins; D051844:alpha-Synuclein
D000911:Antibodies, Monoclonal; D009419:Nerve Tissue Proteins; D009566:Nitrates; D010446:Peptide Fragments; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein