Relation of depression diagnoses to 2-year outcomes in cocaine-dependent patients in a randomized continuing care study.
This study examined the relation between depression diagnoses and outcomes in 132 cocaine-dependent patients who were randomized to relapse prevention (RP) or standard 12-step focused group continuing care and followed for 2 years. Depressed patients attended more treatment sessions and had more cocaine-free urines during treatment than participants without depression, but they drank alcohol more frequently before treatment and during the 18-month posttreatment follow-up. Cocaine outcomes in depressed patients deteriorated to a greater degree after treatment than did cocaine outcomes in patients without depression, particularly in patients in RP who had a current depressive disorder at baseline. The best alcohol outcomes were obtained in nondepressed patients who received RP. The results suggest that extended continuing care treatment may be warranted for cocaine-dependent patients with co-occurring depressive disorders.
McKay
James R
JR
Department of Psychiatry, University of Pennsylvania, and Veterans Affairs Medical Center, Philadelphia 19104, USA.
Pettinati
Helen M
HM
Morrison
Rebecca
R
Feeley
Michael
M
Mulvaney
Francis D
FD
Gallop
Robert
R
D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology; D019970:Cocaine-Related Disorders / Q000523:psychology* / Q000534:rehabilitation*; D003866:Depressive Disorder / Q000523:psychology*; D017831:Diagnosis, Dual (Psychiatry); D006801:Humans; D008297:Male; D012008:Recurrence; D012044:Regression Analysis; D016896:Treatment Outcome