An efficient synthesis of novel carbocyclic nucleosides with use of ring-closing metathesis from D-lactose.
This paper describes an efficient synthetic route for various types of novel carbocyclic nucleosides. The required stereochemistry of the targeted nucleosides was successfully obtained with use of Grubbs cyclization and Trost allylic alkylation from the carbohydrate chiral template "D-lactose".
Hong
Joon Hee
JH
College of Pharmacy and College of Education, Chosun University, Kwangju 501-759, South Korea. hongjh@mail.chosun.ac.kr
Shim
Myung Jung
MJ
Ro
Bong Oh
BO
Ko
Ok Hyun
OH