title: Intestinal microsporidiosis in HIV-infected children with diarrhea.
abstract: Intestinal microsporidiosis is a common opportunistic disease associated with diarrhea in adult AIDS patients in Thailand; the data regarding this infection in children are scarce. The present study was designed to investigate the prevalence and clinical features of intestinal microsporidiosis in hospitalized HIV-infected and uninfected (free of HIV) children with diarrhea. Of the 95 HIV-infected children and 87 uninfected children, 24 (25.3%) and 13 (14.9%) respectively were diagnosed with intestinal microsporidiosis. Species identification of microsporidia spores, by transmission electron microscopy, demonstrated Enterocytozoon bieneusi in 5 cases. Cryptosporidium parvum was a common coinfective parasite; pneumonia was the most frequent concurrent disease found in children with intestinal microsporidiosis. Malnutrition was commoner in the HIV-infected group (79.2% vs 23.1%; p = 0.003). This study indicates that intestinal microsporidiosis is an important disease in both HIV-infected and uninfected Thai children with diarrhea.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Darawan
authors.initials: D
authors.lastname: Wanachiwanawin
authors.forename: Kulkanya
authors.initials: K
authors.lastname: Chokephaibulkit
authors.forename: Punpob
authors.initials: P
authors.lastname: Lertlaituan
authors.forename: Jeerawan
authors.initials: J
authors.lastname: Ongrotchanakun
authors.forename: Pisith
authors.initials: P
authors.lastname: Chinabut
authors.forename: Kleophant
authors.initials: K
authors.lastname: Thakerngpol
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007411:Intestinal Diseases, Parasitic / Q000150:complications*; D008297:Male; D016881:Microsporidiosis / Q000150:complications*; D013785:Thailand