Quantitative trait loci and candidate genes regulating HDL cholesterol: a murine chromosome map.
OBJECTIVE
Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans.


RESULTS
We summarized the 27 QTL and candidate genes associated with HDL-C concentrations in mice and plotted them on a mouse chromosome map. We also summarized the 22 human QTL for HDL-C levels and compared them with those of the mouse by comparative genomics. At least part of the mouse homologies for 18 of the 22 human HDL-C QTL were within the murine HDL-C QTL.


CONCLUSIONS
Murine QTL for HDL-C levels may predict their homologous location in humans, and their underlying genes may be appropriate genes to test in humans.
Wang
Xiaosong
X
Jackson Laboratory, Bar Harbor, Me 04609, USA.
Paigen
Beverly
B
D000818:Animals; D008076:Cholesterol, HDL / Q000235:genetics*; D002874:Chromosome Mapping; D005809:Genes, Regulator / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D051379:Mice; D019655:Quantitative Trait, Heritable
D008076:Cholesterol, HDL; D005819:Genetic Markers