title: Hand strength and fatigue in patients with hereditary motor and sensory neuropathy (types I and II).
abstract: OBJECTIVE
  To compare maximal isometric hand strength and fatigue between subjects with hereditary motor and sensory neuropathy (HMSN) and healthy controls and to test the reproducibility of handgrip strength (peak force of handgrip [PFgrip]) and fatigue.
  
  
  METHODS
  PFgrip and the decline in PFgrip during 3 sets of 15 contractions were compared.
  
  
  METHODS
  University hospital in The Netherlands.
  
  
  METHODS
  Twenty subjects with HMSN and 20 age- and sex-matched healthy controls; 15 healthy subjects for the reproducibility part of the study.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  PFgrip and the decline in PFgrip were compared by using a digital handgrip dynamometer. Two-point and lateral pinch measurements of subjects with HMSN were standardized against reference values. Reproducibility measurements were performed on 15 healthy subjects on 2 separate occasions within a 1-week interval.
  
  
  RESULTS
  PFgrip was significantly lower in the HMSN subjects compared with controls (P<.05). Pinch measurements also showed a large variance from average normal performance. No significant difference was found in the decline in percentage of PFgrip. Reproducibility was excellent for PFgrip (intraclass correlation coefficient [ICC]=.98; 95% confidence interval [CI],.95-.99) but poor for fatigue (ICC=.62; 95% CI,.20-.85).
  
  
  CONCLUSIONS
  PFgrip and 2-point and lateral pinch in HMSN subjects were significantly reduced compared with healthy controls. Our findings indicated that the rate of decline of PFgrip during effort does not vary between groups.
authors.affiliation: Department of Rehabilitation Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. annemieke@videler.nl
authors.forename: Annemieke J
authors.initials: AJ
authors.lastname: Videler
authors.forename: Anita
authors.initials: A
authors.lastname: Beelen
authors.forename: Geert
authors.initials: G
authors.lastname: Aufdemkampe
authors.forename: Imelda J
authors.initials: IJ
authors.lastname: de Groot
authors.forename: Marc
authors.initials: M
authors.lastname: Van Leemputte
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D015417:Hereditary Sensory and Motor Neuropathy / Q000503:physiopathology*; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology*; D008297:Male; D018763:Muscle Fatigue / Q000502:physiology*; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric