Beta- and alpha-globin genotypes in Albanian patients affected by beta-globin gene disorders.
We investigated the molecular basis of hemoglobinopathies and restriction fragment length polymorphism (RFLP) haplotypes in 58 unrelated Albanian patients. A wise heterogeneity was detected, characterized by 11 beta-thalassemia, 3 Hb variant and 4 alpha-globin alleles. All beta-thalassemia and Hb variant alleles were associated with the same haplotypes described in other populations. Genotype-phenotype correlation was established.
De Angioletti
Maria
M
Lacerra
Giuseppina
G
Boletinio
Enis
E
Di Noce
Francesca
F
Musollino
Gennaro
G
Carestia
Clementina
C
D000415:Albania / Q000453:epidemiology; D000483:Alleles; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006453:Hemoglobinopathies / Q000453:epidemiology / Q000235:genetics*; D006801:Humans
D005914:Globins