title: The improvement of luteal insufficiency in fecund women by tokishakuyakusan treatment.
abstract: The effect of tokishakuyakusan, a Chinese herbal medicine, was examined, in vivo, in women with luteal insufficiency and in women with normal menstrual cycles. Luteal insufficiency was determined by daily measurement of basal body temperature and plasma progesterone levels. Tokishakuyakusan improved luteal insufficiency. Furthermore, the effects of tokishakuyakusan on prolactin, gonadotropins, steroids, angiotensin II, ANP and renin levels in the blood of women with normal menstrual cycles were studied, as were the medicine's effects on estrogens, pregnenediol and LH in the urine of the same women. Tokishakuyakusan had no adverse effect on hormonal levels in either blood or urine. Furthermore, no clinical side effects were detected. These results suggest that tokishakuyakusan improves luteal insufficiency in women but does not affect the hormonal levels of women with normal menstrual cycles.
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Usuki
authors.forename: Tomoko Nakauchi Sawako
authors.initials: TN
authors.lastname: Higa
authors.forename: Katsumi
authors.initials: K
authors.lastname: Soreya
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000097:blood / Q000187:drug effects; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood / Q000652:urine; D005260:Female; D005299:Fertility Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000187:drug effects; D008597:Menstrual Cycle / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal; D011374:Progesterone / Q000097:blood / Q000652:urine; D011388:Prolactin / Q000097:blood / Q000187:drug effects; D012083:Renin / Q000097:blood / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D005299:Fertility Agents; D006062:Gonadotropins; C413220:toki-shakuyaku-san; D000804:Angiotensin II; D011374:Progesterone; D004958:Estradiol; D009320:Atrial Natriuretic Factor; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D012083:Renin