Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human endothelial cells.
A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery endothelial cells (ECs) and human coronary artery smooth muscle cells (SMCs). Compound was superior to Tranilast, in terms of both cell selectivity and the potency of its inhibitory activity toward the proliferation and angiogenesis of ECs.
Ogita
Haruhisa
H
Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, 3-17-35, Niizo-Minami, Toda-shi, Saitama 335-8502, Japan.
Isobe
Yoshiaki
Y
Takaku
Haruo
H
Sekine
Rena
R
Goto
Yuso
Y
Misawa
Satoru
S
Hayashi
Hideya
H
D000577:Amides / Q000138:chemical synthesis*; D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects
D000577:Amides; D020533:Angiogenesis Inhibitors; D007202:Indicators and Reagents; D004247:DNA