title: Carvedilol-induced changes in cardiac diastolic performance in a patient with isolated noncompaction of the myocardium.
abstract: Isolated ventricular noncompaction (IVNC) is an unusual congenital heart disease. The morphological features are trabeculations and intertrabecular recesses within the left ventricle. Important clinical considerations include the high mortality due to depressed cardiac function, and the instance of ventricular arrhythmia and systemic embolism. One of reasons for the high mortality is that there is still no effective therapy with the exception of the recommendation for anticoagulation therapy to prevent embolisms. Hence, we describe a 29-year-old man with IVNC presenting with chronic heart failure. Careful up-titration of carvedilol in this patient changed the parameters of cardiac diastolic performance
authors.affiliation: Department of Cardiology, Sakakibara Heart Institute, Tokyo.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Harada
authors.forename: Eiji
authors.initials: E
authors.lastname: Ohtaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Kitahara
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Saichi
authors.initials: S
authors.lastname: Hosoda
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D000077261:Carvedilol; D003971:Diastole / Q000187:drug effects; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005080:Exercise Test; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000097:blood; D011412:Propanolamines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D009479:Neuropeptides; D011412:Propanolamines; D000077261:Carvedilol