title: Saccopetrins A and B, two novel gamma-lactones from Saccopetalum prolificum.
abstract: Two new gamma-lactones, saccopetrin A (1) and saccopetrin B (2), together with 10 known compounds have been isolated from the roots of Saccopetalum prolificum. Their structures were established by spectroscopic and chemical methods. The absolute configuration of 1 was determined by chemical transformation and the Mosher method. Cytotoxic activities were evaluated against several different cell lines. Compound 2 exhibited stronger cytotoxic activities than 1 against KB and HCT-8 cell lines at a concentration of 10(-5) mol/L.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's of Republic of China.
authors.forename: Ming-Lei
authors.initials: ML
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: Fei-Zhi
authors.initials: FZ
authors.lastname: Xie
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D007783:Lactones; D036702:Quassins; C467917:yadanziolide S