Efficient liquid-phase synthesis of 2'-hydroxychalcones.
The condensation of 2'-hydroxyacetophenone (1) with aromatic aldehydes (2) in a well closed vessel using microwave irradiation or classical heating at 132 degrees C, provides a fast and simple method for the liquid-phase synthesis of 2'-hydroxychalcones without formation of by-products. Antiproliferative activity of these compounds were evaluated using MCF-7 cells.
Stoyanov
Edmont V
EV
Department of Industrial Pharmacy, Faculty of Pharmacy, Sofia, Bulgaria. estoyanov@yahoo.com
Champavier
Yves
Y
Simon
Alain
A
Basly
Jean-Philippe
JP
D000447:Aldehydes; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D047188:Chalcones; D004354:Drug Screening Assays, Antitumor; D006358:Hot Temperature; D007202:Indicators and Reagents; D008872:Microwaves; D014407:Tumor Cells, Cultured
D000447:Aldehydes; D000970:Antineoplastic Agents; D047188:Chalcones; D007202:Indicators and Reagents; D002599:Chalcone; C013031:2'-hydroxychalcone