Zanamivir is an effective treatment for influenza in children undergoing therapy for acute lymphoblastic leukemia.
We diagnosed influenza infection in 2 children receiving maintenance treatment for acute lymphoblastic leukemia. Both patients received zanamivir within 1 d of the onset of fever and their symptoms of influenza were rapidly alleviated. We conclude that inhaled zanamivir seems to be an effective treatment for influenza infection in immunocompromised patients.
Maeda
Miho
M
Department of Pediatrics, Nippon Medical School, Tokyo, Japan. maeda@nms.ac.jp
Fukunaga
Yoshitaka
Y
Asano
Takeshi
T
Migita
Makoto
M
Ueda
Takahiro
T
Hayakawa
Jun
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006146:Guanidines; D006801:Humans; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011714:Pyrans; D018570:Risk Assessment; D012794:Sialic Acids / Q000627:therapeutic use*; D016896:Treatment Outcome; D053243:Zanamivir
D000998:Antiviral Agents; D006146:Guanidines; D011714:Pyrans; D012794:Sialic Acids; D053243:Zanamivir