Vertebrate sex determination: a new player in the field.
Sex-determining genes have been identified in flies, worms and mammals but not, until recently, in non-mammalian vertebrates. Now, a gene has been isolated from the Y chromosome of the teleost fish medaka that is functionally comparable to the mammalian testis-determining gene, Sry.
Swain
Amanda
A
Section of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, London SW3 6JB, UK. aswain@icr.ac.uk
D000818:Animals; D001717:Birds / Q000235:genetics / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D019143:Evolution, Molecular; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008297:Male; D051379:Mice; D009990:Oryzias / Q000235:genetics / Q000502:physiology; D020033:Protein Isoforms / Q000502:physiology; D017434:Protein Structure, Tertiary; D012730:Sex Chromosomes / Q000235:genetics; D019849:Sex Determination Processes; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014714:Vertebrates / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; C110547:DMRT1 protein; D029721:Drosophila Proteins; D020033:Protein Isoforms; D014157:Transcription Factors