title: 3'-amino-2',4'-BNA: novel bridged nucleic acids having an N3'-->P5' phosphoramidate linkage.
abstract: Novel oligonucleotide analogues, containing a 3'-amino-2',4'-BNA unit, were successfully synthesized, and they showed superior duplex and triplex forming ability as well as BNA itself, along with remarkable enzymatic stability.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Obika
authors.forename: M
authors.initials: M
authors.lastname: Onoda
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: J
authors.initials: J
authors.lastname: Andoh
authors.forename: M
authors.initials: M
authors.lastname: Koizumi
authors.forename: T
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D000577:Amides / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010756:Phosphoric Acids / Q000737:chemistry*; D010727:Phosphoric Diester Hydrolases / Q000494:pharmacology; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D012910:Snake Venoms / Q000201:enzymology
chemical_list: D000577:Amides; D001952:Bridged-Ring Compounds; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D010756:Phosphoric Acids; D012910:Snake Venoms; D012313:RNA; D004247:DNA; C011067:phosphoramidic acid; D010727:Phosphoric Diester Hydrolases