Microwave-accelerated homogeneous catalysis in organic chemistry.
The efficiency of microwave flash heating in accelerating organic transformations (reaction times reduced from days and hours to minutes and seconds) has recently been proven in several different fields of organic chemistry. This specific account mainly summarizes our own experiences in developing rapid, robust, and selective microwave-assisted transition metal-catalyzed homogeneous reactions. Applications include selective Heck couplings, cross-couplings, and asymmetric substitutions. The science of green chemistry was developed to meet the increasing demand for environmentally benign chemical processes. We believe the combination of metal catalysis and microwave heating will be of importance in the search for green laboratory-scale synthesis.
Larhed
Mats
M
Department of Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.
Moberg
Christina
C
Hallberg
Anders
A
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods* / Q000592:standards; D004787:Environmental Pollution / Q000517:prevention & control*; D006361:Heating; D007700:Kinetics; D008872:Microwaves; D015394:Molecular Structure