The supratrigeminal region of the rat sends GABA/glycine-cocontaining axon terminals to the motor trigeminal nucleus on the contralateral side.
The supratrigeminal region (STR), a reticular zone capping the motor trigeminal nucleus (Tm), contains gamma-aminobutyric acid (GABA)ergic and glycinergic neurons which send axons to the contralateral Tm (J. Comp. Neurol. 373 (1996) 498). In the present study we observed that some single synaptic terminals upon Tm motoneurons showed immunoreactivities (IRs) for both glutamic acid decarboxylase (GAD) and glycine transporter 2 (GlyT2). After injecting biotinylated dextran amine (BDA) into the STR, we further observed in the Tm contralateral to the BDA injection that some BDA-labeled axon terminals in close contact with Tm motoneurons showed both GAD- and GlyT2-IRs. Thus, the STR was indicated to send GABAergic/glycinergic axon terminals contralaterally to Tm motoneurons.
Li
Yun-Qing
YQ
Department of Anatomy and K.K. Leung Brain Research Center, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.
Tao
Fa-Sheng
FS
Okamoto
Keiko
K
Nomura
Sakashi
S
Kaneko
Takeshi
T
Mizuno
Noboru
N
D026921:Amino Acid Transport Systems, Neutral / Q000032:analysis / Q000502:physiology; D000818:Animals; D005968:Glutamate Decarboxylase / Q000032:analysis / Q000502:physiology; D005998:Glycine / Q000032:analysis* / Q000502:physiology; D050487:Glycine Plasma Membrane Transport Proteins; D008297:Male; D009434:Neural Pathways / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D017729:Presynaptic Terminals / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D014278:Trigeminal Nuclei / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000032:analysis* / Q000502:physiology
D026921:Amino Acid Transport Systems, Neutral; D050487:Glycine Plasma Membrane Transport Proteins; C493269:Slc6a5 protein, rat; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; D005998:Glycine