title: Inhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats.
abstract: OBJECTIVE
  To investigate the effects and mechanism of succinic acid on pentylenetetrazol (PTZ) chemical kindling and amygdala electrical kindling in rats.
  
  
  METHODS
  PTZ chemical kindling and amygdala electrical kindling models were established in rats. The effects of succinic acid on the behavior and afterdischarge of kindled rats were observed. The mice were pretreated with succinic acid, 30 min later, picrotoxin, a GABAA receptor antagonist was given by ip, then the effects of succinic acid on mice were observed.
  
  
  RESULTS
  Succinic acid (100-400 mg/kg, ip) dose-dependently inhibited PTZ chemical and amygdala kindled seizure (P<0.05, P<0.01), elevated the afterdischarge threshold, and reduced the Racine's stage of amygdala kindling rats (P<0.05, P<0.01); succinic acid (200-400 mg/kg, ip) inhibited picrotoxin-convulsion in mice (P<0.05, P<0.01).
  
  
  CONCLUSIONS
  Succinic acid inhibits PTZ chemical and amygdala electrical kindling in rats, and the inhibition mechanism may be related to the enhancement of GABAergic system action in the brain, especially through GABAA receptors.
authors.affiliation: Department of Pharmacology, Medical College, Qingdao University, Qingdao 266021, China. faoqmc@public.qd.sd.cn.
authors.forename: Wang
authors.initials: W
authors.lastname: Yue
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Liu
authors.forename: Dong-Lian
authors.initials: DL
authors.lastname: Zang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000679:Amygdala; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004558:Electric Stimulation; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D007696:Kindling, Neurologic; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000378:metabolism; D019802:Succinic Acid / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D018079:Receptors, GABA; D019802:Succinic Acid; D010433:Pentylenetetrazole