Hepatoblastoma and low birth weight: a trend or chance observation?
BACKGROUND
Several reports have suggested an association between prematurity and hepatoblastoma (HB).


METHODS
Data were collected by questionnaires from 105 children with HB enrolled in a Children's Cancer Group (CCG) study.


RESULTS
Observed over expected rates were increased about 2- and 15+-fold for prematurity (<37 weeks at birth) and low birth weight (<1,000 g) respectively. Similar data were derived from a later CCG study of 36 HB children.


CONCLUSIONS
Early reports of a possible association between prematurity and HB have been confirmed.
Feusner
James
J
Oncology, Children's Hospital Oakland, Oakland, California 94609, USA. jfeusner@mail.cho.org
Plaschkes
J
J
D005260:Female; D005865:Gestational Age; D018197:Hepatoblastoma / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy