Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice.
OBJECTIVE
We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases).


METHODS
The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured.


RESULTS
Only tyrphostins and NS-398 administered 2 h before LPS successfully delayed preterm birth (p < 0.05).


CONCLUSIONS
Both tyrphostins AG126 and AG1288 as well as NS-398 inhibited LPS induced preterm birth to the time of normal birth.
Mijovic
Jane E
JE
Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.
Zakar
Tamas
T
Zaragoza
Dean B
DB
Olson
David M
DM
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009578:Nitrobenzenes / Q000494:pharmacology; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013047:Specific Pathogen-Free Organisms; D013449:Sulfonamides / Q000494:pharmacology; D020032:Tyrphostins / Q000494:pharmacology*
D008070:Lipopolysaccharides; D009578:Nitrobenzenes; D013449:Sulfonamides; D020032:Tyrphostins; C069028:AG 127; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D011505:Protein-Tyrosine Kinases