title: Bactericidal activity of Ag-zeolite mediated by reactive oxygen species under aerated conditions.
abstract: The bactericidal activity induced by the introduction of silver ions into zeolite was studied. Escherichia coli was used as the test microorganism. Silver ions were loaded into zeolite by the ion-exchange method. Silver-loaded zeolite was demonstrated the strong bactericidal activity. Dissolved oxygen was an essential factor for the occurrence of the bactericidal activity because the activity was observed only under aerated condition. Superoxide anions, hydrogen peroxide, hydroxyl radicals and singlet oxygen were formed. Scavengers of these each reactive oxygen species (ROS) inhibited the bactericidal activity. This means that all ROS contributed to the activity.
authors.affiliation: Department of Microbiology, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo, Japan. inoue@ac.shoyaku.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Inoue
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hoshino
authors.forename: Hiroo
authors.initials: H
authors.lastname: Takahashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Noguchi
authors.forename: Tomomi
authors.initials: T
authors.lastname: Murata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kanzaki
authors.forename: Hajime
authors.initials: H
authors.lastname: Hamashima
authors.forename: Masanori
authors.initials: M
authors.lastname: Sasatsu
mesh_terms: D000332:Aerobiosis; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003574:Cytochrome c Group / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D016166:Free Radical Scavengers / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D009584:Nitrogen / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012834:Silver; D026082:Singlet Oxygen / Q000378:metabolism; D012997:Solvents; D013481:Superoxides / Q000378:metabolism; D017641:Zeolites / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003574:Cytochrome c Group; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D012997:Solvents; D013481:Superoxides; D017641:Zeolites; D026082:Singlet Oxygen; D017665:Hydroxyl Radical; D012834:Silver; D006861:Hydrogen Peroxide; D002374:Catalase; D009584:Nitrogen; D010100:Oxygen