[Influence of lead on activity of nitric oxide synthase in neurons and vessel smooth muscle of small intestine in rats].
The beta-NADPH histochemical method was used to study the effect of lead on activity of nitric oxide synthase(NOS) in neurons and vessel smooth muscles of intestinal wall in rats. The results showed that the number of NOS positive neurons and fibers was decreased and degenerative changes of some NOS positive neurons were found after the lead acetate intraperitoneal injection. The activity of NOS in the vessel smooth muscles was reduced. It suggests that lead colic may be induced by reduction of NO in the neurons which innervate the gut smooth muscles.
Kong
X Y
XY
Department of Hygiene, Hunan Medical University, Changsha 410078.
Liao
L M
LM
Lei
D L
DL
Huang
J F
JF
Wen
X D
XD
D000818:Animals; D005260:Female; D007421:Intestine, Small / Q000201:enzymology / Q000294:innervation; D007854:Lead / Q000633:toxicity*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000201:enzymology*; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D007854:Lead; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat