Effect of AGEs on human disc herniation: intervertebral disc hernia is also effected by AGEs.
Currently, extracellular matrix MMP has been discussed in relation to the extrusion and spontaneous regression of the herniated mass observed in lumbar disc herniation. However, the question remains as to whether degenerated protein is really the cause of this condition's pathogenesis. We confirmed immunologically by means of electron microscopy that extrusion is caused by the AGEs (advanced glycation end products)-induced cross-linking of collagen, and that spontaneous regression is due to AGE receptors on macrophages. Further, AGEs were found to be already exposed during histogenesis, suggesting a relation to apoptosis. In lumbar disc herniation and aging, glucose-derived AGEs cross-link proteins and cause vascular tissue damage.
Tsuru
Michiyo
M
Department of Orthopaedic Surgery, Kurume University School of Medicine, Kurume 830-0011, Japan. michiyo@med.kurume-u.ac.jp
Nagata
Kensei
K
Jimi
Atsuo
A
Irie
Kouji
K
Yamada
Akira
A
Nagai
Ryoji
R
Horiuchi
Seikoh
S
Sata
Michio
M
D001483:Base Sequence; D017931:DNA Primers; D017127:Glycation End Products, Advanced / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D007405:Intervertebral Disc Displacement / Q000503:physiopathology*; D008159:Lumbar Vertebrae; D008854:Microscopy, Electron; D020133:Reverse Transcriptase Polymerase Chain Reaction
D017931:DNA Primers; D017127:Glycation End Products, Advanced