The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).
Interleukin-10 (IL-10) is an immunoregulatory cytokine that plays a crucial role in inflammatory and immune reactions. It has potent anti-inflammatory and immunosuppressive activities on myeloid cell functions which forms a solid basis for its use in acute and chronic inflammatory diseases. Here, we discuss the role of IL-10 in autoimmune diseases and examine its beneficial effects in cellular-based autoimmune diseases such as multiple sclerosis (MS) or its involvement in humoral-based autoimmune diseases such as systemic lupus erythematosus (SLE). Inhibition of the immune stimulatory activities of IL-10 may provide novel approaches in the treatment of humoral autoimmune diseases, infectious diseases and cancer.
Beebe
Amy M
AM
Department of Experimental Pathology, DNAX Research Inc., 901 California Avenue, Palo Alto, CA 94304-1104, USA. amy.beebe@dnax.org
Cua
Daniel J
DJ
de Waal Malefyt
Rene
R
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology*; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D016753:Interleukin-10 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000503:physiopathology*; D008213:Lymphocyte Activation; D051379:Mice; D008814:Mice, Inbred NZB; D018448:Models, Immunological; D009103:Multiple Sclerosis / Q000276:immunology / Q000503:physiopathology*; D011110:Polymorphism, Genetic; D018417:Th1 Cells / Q000276:immunology
D016207:Cytokines; D007155:Immunologic Factors; D016753:Interleukin-10