title: [Relationship between the quantities of virus and the models of serologic markers in patients infected with HBV].
abstract: OBJECTIVE
  To explore the relationship between the quantities of HBV and the models of serologic markers.
  
  
  METHODS
  Real-time fluorescent quantitative PCR was used to measure the HBV DNA and ELISA was used to detect the antigen/antibody of HBV.
  
  
  RESULTS
  The patients whose HBV copies were more than 10(3)/ml accounted for 87.3%, whose copies were more than 10(7)/ml accounted for 66.7% among the HBsAg and HBeAg -positive patients. The patients whose HBV copies were less than 10(3)/ml accounted for 74.5%, whose HBV copies were more than 10(7)/ml accounted for 8.3% among the HBeAg-negative patients. The HBV copies of HBeAg-positive patients were significantly more than HBeAg-negative patients (P<0.01). The HBV copies of anti-HBe-negative patients were significantly more than anti-HBe-positive patients (P<0.01). The HBV DNA was detected in some HBsAg-negative patients. One patient's HBV copies were as high as 1.59 10(9)/ml.
  
  
  CONCLUSIONS
  The HBV copies of HBeAg-positive patients are significantly more than HBeAg-negative patients, The HBV copies of anti-HBe-negative patients are significantly more than the anti-HBe-positive patients. However, some HBeAg-positive patient's HBV copies are very low, and some HBeAg-negative patient's HBV copies are very high. HBV DNA even could be detected in some HBsAg-negative patients. It is difficult to judge accurately the quantities of HBV and infectivity according to the serologic markers for a specific patient.
authors.affiliation: Liver Disease Research Center, Xiangya Second Affiliated Hospital, Central South University, Changsha 410011, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
authors.forename: Hong Yu
authors.initials: HY
authors.lastname: Luo
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Huan Ying
authors.initials: HY
authors.lastname: Qian
authors.forename: Xiao Bo
authors.initials: XB
authors.lastname: Zeng
authors.forename: Li
authors.initials: L
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens