Elimination of Pasteurella pneumotropica from a contaminated mouse colony by oral administration of Enrofloxacin.
Enrofloxacin, a fluoroquinolone bactericidal antibiotic, was administered in an attempt to eradicate Pasteurella pneumotropica (P. pneumotropica) from a contaminated mouse colony. Contaminated mice, maintained within 4 animal rooms, were administered Enrofloxacin in drinking water at a daily dosage of 25.5 mg/kg for 2 weeks. Following one week of Enrofloxacin treatment, mice were selected randomly from each room and examined for P. pneumotropica. This procedure was repeated two or three times until all mice examined tested negative for the Pasteurella strain. With the exception of one room, treated mice consistently tested negative for P. pneumotropica for up to 45 weeks following completion of Enrofloxacin treatment. Thus, oral administration of Enrofloxacin significantly eliminated P. pneumotropica from a contaminated mouse colony.
Ueno
Yutaka
Y
Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Shimizu
Ritsuko
R
Nozu
Ryoko
R
Takahashi
Satoru
S
Yamamoto
Masayuki
M
Sugiyama
Fumihiro
F
Takakura
Akira
A
Itoh
Toshio
T
Yagami
Ken-ichi
K
D000284:Administration, Oral; D000818:Animals; D000830:Animals, Laboratory / Q000382:microbiology*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D051379:Mice; D010325:Pasteurella / Q000187:drug effects*; D015363:Quinolones / Q000008:administration & dosage*; D011897:Random Allocation
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin