title: Effect of porous xenographic bone graft with collagen barrier membrane on periodontal regeneration.
abstract: The purpose of this study was to investigate the effect of porous xenographic bone graft (Bio-Oss) with a collagen barrier membrane (Bio-Gide) on formation of new cementum and new bone in experimental intrabony defects of dogs. The intrabony defects were treated by either guided tissue regeneration with the collagen membrane (control group) or the collagen membrane with the porous bone mineral graft (experimental group). After 8 weeks, the animals were sacrificed and the tissues were histologically examined. New cementum with inserting collagen fibers was observed on the exposed surfaces in both groups. The amount of nevv bone was significantly greater in the group using the bone graft with the membrane than in the control group. The use of the collagen barrier membrane in combination with the porous bone graft material may enhance new bone and cementum formation.
authors.affiliation: Department of Periodontics, Tokyo Dental College, Chiba, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Shima
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kitamura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugito
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001672:Biocompatible Materials; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D025021:Cementogenesis / Q000502:physiology; D003094:Collagen; D004396:Coloring Agents; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D004285:Dogs; D004846:Epithelial Attachment / Q000473:pathology; D005881:Gingiva / Q000473:pathology; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use*; D010513:Periodontal Ligament / Q000473:pathology; D016062:Porosity; D018709:Statistics, Nonparametric; D013997:Time Factors; D014092:Tooth Root / Q000473:pathology; D014183:Transplantation, Heterologous
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D004396:Coloring Agents; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen