Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam.
The aqueous extract of Centranthus longiflorus ssp. longiflorus (CLE) was investigated for sedative, anticonvulsant and behaviour modifying activity using thiopental sleeping, caffeine induced convulsion and forced swimming depression tests. When the effects of the aqueous extract of CLE (100 mg/kg) was compared to diazepam, it showed similar sedative and anticonvulsant effects to those produced by diazepam (5 mg/kg).
Büyükokuroğlu
M E
ME
Department of Pharmacology, Atatürk University, Faculty of Medicine, Erzurum, Turkey.
Demirezer
L O
LO
Güvenalp
Z
Z
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine; D000697:Central Nervous System Stimulants; D003863:Depression / Q000517:prevention & control; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D013550:Swimming / Q000523:psychology; D013874:Thiopental / Q000494:pharmacology; D014421:Turkey; D028161:Valerianaceae / Q000737:chemistry* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000927:Anticonvulsants; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D002110:Caffeine; D005680:gamma-Aminobutyric Acid; D013874:Thiopental; D000241:Adenosine; D003975:Diazepam