title: [Activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R) and superoxide dismutase (SOD-1) in single brain metastasis].
abstract: The aim of the study was to evaluate the activity of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R) and superoxide dysmutase (SOD-1) in the single brain metastases. The activity of the GSH-Px was evaluated with the use of spectrophotometry, GSSG-R was evaluated basing on the method of Mize and Langdon and SOD-1 with Sykes et al. method. The examinations were carried out in 36 specimens (10 specimens of healthy brain tissue, 12 specimens of brain metastases, 14 specimens of glioma multiforme). The statistical analysis revealed significant increase (p < 0.001) of GSH-Px and GSSG-R activity within the single brain metastases in comparison with the healthy brain tissue.
authors.affiliation: Kliniki Neurochirurgii, Akademii Medycznej w Białymstoku.
authors.forename: Henryk
authors.initials: H
authors.lastname: Dudek
authors.forename: Ryszard
authors.initials: R
authors.lastname: Farbiszewski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Michno
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kozłowski
mesh_terms: D001932:Brain Neoplasms / Q000201:enzymology* / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000556:secondary; D005260:Female; D005909:Glioblastoma / Q000201:enzymology / Q000556:secondary; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase