Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.
OBJECTIVE
Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE.


METHODS
In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured.


RESULTS
Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness.


CONCLUSIONS
The DMAE formulation under investigation increased skin firmness.
Uhoda
Isabelle
I
Unit of Dermocosmetology, Department of Dermatopathology, University Medical Center of Liège, CHU Sart Tilman, B-4000 Liège, Belgium.
Faska
Najat
N
Robert
Caroline
C
Cauwenbergh
Geert
G
Piérard
Gérald E
GE
D000328:Adult; D016880:Anisotropy; D003642:Deanol / Q000494:pharmacology*; D003879:Dermatologic Agents / Q000494:pharmacology*; D003880:Dermatology / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D008875:Middle Aged; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D010865:Pilot Projects; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D013396:Suction; D013718:Tensile Strength
D003879:Dermatologic Agents; D005782:Gels; D014677:Pharmaceutical Vehicles; D003642:Deanol