title: Overexpression of TIAP/m-survivin in thymocytes enhances cell proliferation.
abstract: TIAP/m-survivin, a member of the inhibitor of apoptosis (IAP) protein family, is expressed in a cell cycle dependent manner. It is strongly expressed in various subsets of thymocytes. To investigate a role of TIAP/m-survivin in thymocytes, mice carrying the lck-TIAP transgene were established. Two out of six transgenic mice expressed large amounts of TIAP mRNA and protein in thymocytes. Although T cell development and apoptosis of thymocytes were largely unaffected in lck-TIAP mice, transgenic thymocytes displayed hyperproliferation in response to PMA and ionomycin but not to anti-CD3 antibody. Thus, overexpression of TIAP/m-survivin augments cell proliferation of thymocytes to a certain stimulation.
authors.affiliation: Department of Developmental Genetics (H2), Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Satosi
authors.initials: S
authors.lastname: Hikita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hatano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Inoue
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sekita
authors.forename: Koichi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Otaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ogasawara
authors.forename: Seiji
authors.initials: S
authors.lastname: Okada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hirasawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tokuhisa
mesh_terms: D000818:Animals; D017209:Apoptosis; D005656:Fungal Proteins / Q000502:physiology; D051034:Inhibitor of Apoptosis Proteins; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D008822:Mice, Transgenic; D012097:Repressor Proteins / Q000502:physiology*; D000077022:Survivin; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: C117749:Birc5 protein, mouse; D005656:Fungal Proteins; D051034:Inhibitor of Apoptosis Proteins; D012097:Repressor Proteins; D000077022:Survivin