Incorporation of lipophilic pathways into the porous pathway model for describing skin permeabilization during low-frequency sonophoresis.
Application of low-frequency sonophoresis (LFS) has been shown to increase skin permeability, thereby facilitating delivery of hydrophilic solutes. We have previously shown that the modified porous pathway model provides an adequate theoretical description of transdermal delivery of hydrophilic solutes through pores in the presence and absence of ultrasound. However, small hydrophilic solutes (M(w)<400 Da) that exhibit a moderate partition coefficient, K(o/w) (0.1<K(o/w)<1), may also have a substantial contribution to permeability from transport through intercellular lipid bilayers. The aim of this note is to incorporate the lipophilic pathway into the porous pathway model to describe transdermal drug transport in the absence and presence of ultrasound.
Tezel
Ahmet
A
Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Sens
Ashley
A
Mitragotri
Samir
S
D008563:Membrane Lipids / Q000378:metabolism; D008954:Models, Biological; D010539:Permeability / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D014465:Ultrasonics
D008563:Membrane Lipids