Cyclic nucleotide research -- still expanding after half a century.
Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal transduction, receptor-effector coupling, protein-kinase cascades and downregulation of drug responsiveness. The breadth and impact of this work is reflected by five different Nobel prizes.
Beavo
Joseph A
JA
Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA. beavo@u.washington.edu
Brunton
Laurence L
LL
D000818:Animals; D000242:Cyclic AMP / Q000266:history* / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006152:Cyclic GMP / Q000266:history* / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009613:Nobel Prize; D015290:Second Messenger Systems
D017362:Cyclic AMP Response Element-Binding Protein; D000242:Cyclic AMP; D006152:Cyclic GMP