title: [Two cases of renal cell carcinoma with ascites after interleukin-2 therapy].
abstract: One of the most common and problematic side effects of interleukin-2 therapy (IL-2) is vascular leak syndrome (VLS). VLS is characterized by an increase in vascular permeability accompanied by extravasation of fluids and proteins from the capillary vessels into the tissues resulting in interstitial edema, weight gain, pleural effusion, ascites in severe form, multiple organ failure. We, herein, report two cases of VLS, which occurred following IL-2 therapy against metastatic renal cell carcinoma. One of them died of multiple organ failure one month after the cessation of IL-2 therapy.
authors.affiliation: Department of Urology, Osaka Red Cross Hospital.
authors.forename: Go
authors.initials: G
authors.lastname: Kobori
authors.forename: Masanobu
authors.initials: M
authors.lastname: Maegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ushida
authors.forename: Shinya
authors.initials: S
authors.lastname: Maekawa
authors.forename: Koji
authors.initials: K
authors.lastname: Inoue
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Kouhei
authors.initials: K
authors.lastname: Ohmori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishimura
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001201:Ascites / Q000209:etiology*; D019559:Capillary Leak Syndrome / Q000209:etiology*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D007376:Interleukin-2