[Clinical studies using the combination atovaquone-proguanil as malaria prophylaxis in non-immune adult and child travelers].
Prophylaxis for short-term travel in malaria-endemic areas can be difficult for two reasons. The first is that currently available antimalarial drugs are becoming less effective because of the ability of the parasite to adapt to drug pressure. The second involves poor compliance with chemoprophylactic regimens due to the highly restrictive conditions of administration and adverse drug side-effects, especially in "healthy" subjects. The combination of atovaquone/proguanil (Malarone) could provide an answer to both these problems since it is not only effective on multiresistant strains of Plasmodium falciparum but also simplifies the conditions of administration and shows good tolerance in adults and children.
Camus
D
D
Service de Parasitologie-Mycologie, CH et U de Lille, 1 place de Verdun, 59037 Lille, France. daniel.camus@pasteur-lille.fr
Dutoit
E
E
Masson
V
V
Inglebert
P
P
Delhaes
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000008:administration & dosage* / Q000494:pharmacology*; D053626:Atovaquone; D002648:Child; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control*; D008875:Middle Aged; D009285:Naphthoquinones / Q000008:administration & dosage* / Q000494:pharmacology*; D010349:Patient Compliance; D002727:Proguanil / Q000008:administration & dosage* / Q000494:pharmacology*; D014195:Travel
D000962:Antimalarials; D009285:Naphthoquinones; D002727:Proguanil; D053626:Atovaquone