title: Therapy-related acute myeloblastic leukemia after mitoxantrone treatment in a patient with MS.
abstract: The authors report a patient with severe secondary progressive MS who responded to mitoxantrone but developed a fatal acute myeloblastic leukemia 15 months after completion of mitoxantrone therapy. Therapy-related acute leukemia (TRAL) in relation with mitoxantrone is rare; this patient was the first case among a cohort of 802 French MS patients treated with mitoxantrone. Nevertheless, this case stresses the need to further evaluate the long-term risk of TRAL in patients with MS who receive mitoxantrone.
authors.affiliation: Department of Neurology, Hôpital Purpan, Toulouse University Medical Center, Toulouse, France. dbrassat@yahoo.fr
authors.forename: D
authors.initials: D
authors.lastname: Brassat
authors.forename: C
authors.initials: C
authors.lastname: Recher
authors.forename: E
authors.initials: E
authors.lastname: Waubant
authors.forename: E
authors.initials: E
authors.lastname: Le Page
authors.forename: F
authors.initials: F
authors.lastname: Rigal-Huguet
authors.forename: G
authors.initials: G
authors.lastname: Laurent
authors.forename: G
authors.initials: G
authors.lastname: Edan
authors.forename: M
authors.initials: M
authors.lastname: Clanet
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008942:Mitoxantrone / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D008942:Mitoxantrone