title: Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker.
abstract: Voltage-gated Ca(2+) channels play a crucial role in pain perception. We studied the antinociceptive potential of systemically administered mibefradil, a peripherally acting antihypertensive agent and preferential T-type Ca(2+) channel blocker. Systemic injections of mibefradil, in clinically relevant doses, induced mechanical and thermal antinociception in adult rats without compromising their sensorimotor abilities. This suggests that peripherally acting T-type Ca(2+) channel blockers can be useful antinociceptive agents.
authors.affiliation: Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA. st9d@virginia.edu
authors.forename: Slobodan M
authors.initials: SM
authors.lastname: Todorovic
authors.forename: Adam
authors.initials: A
authors.lastname: Meyenburg
authors.forename: Vesna
authors.initials: V
authors.lastname: Jevtovic-Todorovic
mesh_terms: D000700:Analgesics; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020747:Calcium Channels, T-Type / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D007274:Injections, Intraperitoneal; D020748:Mibefradil / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D002121:Calcium Channel Blockers; D020747:Calcium Channels, T-Type; D020748:Mibefradil