Treatment of childhood mycosis fungoides with topical PUVA.
Mycosis fungoides is the most common type of cutaneous T-cell lymphoma, which is usually observed in mid to late adulthood. We report 5 cases of mycosis fungoides in children, all presenting as patch- and plaque-stage disease most commonly involving the buttocks. Histologic examination showed in every case the typical features of mycosis fungoides. In 4 of the 5 cases, the infiltrating lymphocytes were characterized by the T-cell phenotype CD3(+), CD4(+), CD8(+); and in 3 cases, a monoclonal rearrangement of the T-cell receptor gamma (TCR-gamma) gene was found. Three children received topical PUVA treatment, and the other two were treated with mid-potency topical corticosteroids, resulting in complete clinical remission. A management approach to mycosis fungoides with topical PUVA may be appropriate for children.
Pabsch
Heike
H
Department of Dermatology, Dermatohistological Unit, St Barbara Hospital, Duisburg, Germany.
Rütten
Arno
A
Von Stemm
Andrea
A
Meigel
Wilhelm
W
Sander
Christian A
CA
Schaller
Jörg
J
D002081:Buttocks; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000473:pathology; D011701:PUVA Therapy; D012878:Skin Neoplasms / Q000188:drug therapy*
D005938:Glucocorticoids