Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.
A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.
Watterson
Scott H
SH
Bristol-Myers Squibb PRI, PO Box 4000, Princeton, NJ 08543-4000, USA. scott.watterson@bms.com
Liu
Chunjian
C
Dhar
T G Murali
TG
Gu
Henry H
HH
Pitts
William J
WJ
Barrish
Joel C
JC
Fleener
Catherine A
CA
Rouleau
Katherine
K
Sherbina
N Z
NZ
Hollenbaugh
Diane L
DL
Iwanowicz
Edwin J
EJ
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000473:pathology; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
D000577:Amides; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D007202:Indicators and Reagents; D007168:IMP Dehydrogenase