E-cadherin expression in lymph nodes of three patients with non-Hodgkin's lymphoma.
The E-cadherins are a family of cell-cell adhesion molecules. These molecules exhibit Ca2+ dependent cell adhesion and are expressed on epithelial cells. E-cadherin levels in serum are known to be significantly elevated in patients with epithelial carcinomas. We determined serum E-cadherin levels in 30 patients with non-Hodgkin's lymphoma (NHL) using an enzyme immunoassay and then investigated whether E-cadherin is expressed on lymphoma cells in lymph nodes of three cases selected to analyze from 15 cases of serum E-cadherin levels over mean + 2SD with monoclonal antibody immunohistochemistry. Results indicated that E-cadherin antigen is expressed on the lymphoma cells in these three patients with NHL, and that soluble E-cadherin might be released into blood from lymphoma cells. Expression of E-cadherin may contribute to the morphological appearance of some malignant lymphoma, although no conclusion can be drawn based on such small number of patients analyzed.
Takubo
T
T
Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Japan. m3542254@med.osaka-cu.ac.jp
Kanashima
H
H
Terada
Y
Y
Shibata
H
H
Aoyama
Y
Y
Nakamae
H
H
Yamamura
R
R
Shima
E
E
Makita
K
K
Tanaka
K
K
Ohta
K
K
Yamane
T
T
Hino
M
M
Kamitani
T
T
Tatsumi
N
N
Ohshima
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000032:analysis* / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis / Q000097:blood
D015820:Cadherins; D009363:Neoplasm Proteins