[Aggravation by halomethanes of damages in isolated erythrocyte membranes photosensitized by porphyrins].
It was found that halogen methanes (CCl4, CHBr3) enhance the destruction of protein tryptophanyls and lipid peroxidation photosensitized by Zn-tetraphenylporphin and Zn-tetramethylpyridylporphyrin in isolated erythrocyte membranes. It was shown that this effect is due to photoinduced electron transport from Zn-porphyrins to halogen methanes with the formation of highly reactive halogenmethyl radicals. The hydrophilic Zn-tetramethylpyridylporphyrin is more active at the photosensition of damage to membrane proteins, whereas the hydrophobic Zn-tetraphenylporphin is more effective in lipid peroxidation.
Tsvirko
M P
MP
Institute of Photobiology, National Academy of Sciences of Belarus, ul. Akademicheskaya 27, Minsk, 220072 Belarus.
Vorobeĭ
A V
AV
Gurinovich
V V
VV
D002251:Carbon Tetrachloride / Q000494:pharmacology*; D004357:Drug Synergism; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008563:Membrane Lipids / Q000378:metabolism; D008665:Metalloporphyrins / Q000494:pharmacology*; D010084:Oxidation-Reduction; D017319:Photosensitizing Agents / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D022882:Trihalomethanes / Q000494:pharmacology*; D015032:Zinc
D008563:Membrane Lipids; D008665:Metalloporphyrins; D017319:Photosensitizing Agents; D022882:Trihalomethanes; D002251:Carbon Tetrachloride; D015032:Zinc; C015044:bromoform