title: [Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes].
abstract: Human peripheral blood lymphocytes were cultured in diffusion chamber in mice after short-term administration of gossypol acetate.  The induced chromosomal aberrations of human target cells indiffusion chamber were used as indices of DNA damage.  The results showed that the mean frequency of chromosomal aberration of the human lymphocytes in Gossypol-treated mice was slightly higher than that in the control group, but the difference between them was not statistically significant (p 0.05).
authors.forename: Z S
authors.initials: ZS
authors.lastname: Zhang
authors.forename: Y N
authors.initials: YN
authors.lastname: Ding
authors.forename: H Z
authors.initials: HZ
authors.lastname: Zheng
mesh_terms: D000830:Animals, Laboratory; D002869:Chromosome Aberrations; D009358:Congenital, Hereditary, and Neonatal Diseases and Abnormalities; D003267:Contraception; D003270:Contraceptive Agents; D003272:Contraceptive Agents, Male; D004194:Disease; D005193:Family Planning Services; D006072:Gossypol; D012106:Research
chemical_list: D003270:Contraceptive Agents; D003272:Contraceptive Agents, Male; D006072:Gossypol
keywords: Animals, Laboratory; Chromosome Abnormalities; Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Male; Diseases; Family Planning; Gossypol; Neonatal Diseases And Abnormalities; Research Methodology