title: Clinical and economic implications of topical cyclosporin A for the treatment of dry eye.
abstract: The purpose of this study was to investigate clinical, economic, and patient-reported outcomes related to topical cyclosporin A for the treatment of dry eye. The medical records of 181 patients with dry eye were reviewed (mean age, 67.6 yr; 72% women) for up to two years (average follow-up, 1.34 yr) before and after treatment with cyclosporin A 0.05% ophthalmic solution administered topically twice daily. Corneal staining, average discomfort scores, and patient satisfaction markedly improved, whereas the number of prescriptions for ancillary medications and dry eye-related visits to the ophthalmologist declined significantly during the treatment period. In a naturalistic clinical setting, topical cyclosporin A therapy improved the signs and symptoms of dry eye disease, resulting in high patient satisfaction, fewer patients with chronic dry eye visiting the ophthalmologist, and less ancillary drug use.
authors.affiliation: Bellaire Eye & Laser Center, Houston, USA.
authors.forename: Warren D
authors.initials: WD
authors.lastname: Cross
authors.forename: Luis F
authors.initials: LF
authors.lastname: Lay
authors.forename: John G
authors.initials: JG
authors.lastname: Walt
authors.forename: Chris M
authors.initials: CM
authors.lastname: Kozma
mesh_terms: D000287:Administration, Topical; D000368:Aged; D016572:Cyclosporine / Q000008:administration & dosage* / Q000191:economics / Q000627:therapeutic use; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000191:economics; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000191:economics / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D014481:United States
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine