The copper-catalyzed N-arylation of indoles.
A general method for the N-arylation of indoles using catalysts derived from CuI and trans-1,2-cyclohexanediamine (1a), trans-N,N'-dimethyl-1,2-cyclohexanediamine (2a), or N,N'-dimethyl-ethylenediamine (3) is reported. N-Arylindoles can be produced in high yield from the coupling of an aryl iodide or aryl bromide with a variety of indoles.
Antilla
Jon C
JC
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Klapars
Artis
A
Buchwald
Stephen L
SL
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003959:Diamines / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry
D003959:Diamines; D007211:Indoles; D003300:Copper