BH3 domains: intracellular death-ligands critical for initiating apoptosis.
Recent studies have clarified how the BH3 domain, a short peptide motif found in certain BCL-2 family proteins, triggers key mitochondrial events associated with apoptosis.
Chittenden
Thomas
T
ImmunoGen, Inc.,128 Sidney Street, 02139, Cambridge, MA 02319, USA. tom.chittenden@immunogen.com
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051023:BH3 Interacting Domain Death Agonist Protein; D001665:Binding Sites; D002352:Carrier Proteins / Q000502:physiology*; D006801:Humans; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry* / Q000502:physiology; D051025:bcl-Associated Death Protein
C494819:BAD protein, human; D051023:BH3 Interacting Domain Death Agonist Protein; C494814:BID protein, human; D002352:Carrier Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051025:bcl-Associated Death Protein