title: salvador--The persistence of proliferation.
abstract: Despite years of extensive studies on genes that regulate proliferation and cell death, two processes that must be tightly coordinated throughout development to regulate cell number, remarkably few genes have been shown to affect both processes. Using an elegant genetic screen in the fly eye, have identified a gene, salvador, which is especially significant, because it not only regulates and coordinates both exit from the cell cycle and apoptosis, but also has a human homolog that may play a key role in tumorigenesis.
authors.affiliation: Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, 533 Parnassus Avenue, 94143, San Francisco, CA, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Rothenberg
authors.forename: Yuh-Nung
authors.initials: YN
authors.lastname: Jan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D002453:Cell Cycle / Q000235:genetics; D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D005123:Eye / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C465504:sav protein, Drosophila