Effect of nanoparticle encapsulation on the photostability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate.
The aim of this study was to investigate the influence of nanoparticle-based systems on the light-induced decomposition of the sunscreen agent, trans-2-ethylhexyl-p-methoxycinnamate (trans-EHMC). Ethylcellulose (EC) and poly-D,L-lactide-co-glycolide (PLGA) were used as biocompatible polymers for the preparation of the particulate systems. The "salting out" method was used for nanoparticle preparation and several variables were evaluated in order to optimize product characteristics. The photodegradation of the sunscreen agent in emulsion vehicles was reduced by encapsulation into the PLGA nanoparticles (the extent of degradation was 35.3% for the sunscreen-loaded nanoparticles compared to 52.3% for free trans-EHMC) whereas the EC nanoparticle system had no significant effect. Therefore, PLGA nanoparticles loaded with trans-EHMC improve the photostability of the sunscreen agent.
Perugini
P
P
Department of Pharmaceutical Chemistry, University of Pavia, V. le Taramelli 12, Italy.
Simeoni
S
S
Scalia
S
S
Genta
I
I
Modena
T
T
Conti
B
B
Pavanetto
F
F
D002482:Cellulose / Q000031:analogs & derivatives*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000737:chemistry / Q000528:radiation effects*; D004337:Drug Carriers; D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D036103:Nanotechnology; D010316:Particle Size; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D013237:Stereoisomerism; D013473:Sunscreening Agents / Q000737:chemistry / Q000528:radiation effects*; D014466:Ultraviolet Rays
D002934:Cinnamates; D004337:Drug Carriers; D011108:Polymers; D013473:Sunscreening Agents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C118580:octylmethoxycinnamate; C013517:ethyl cellulose; D002482:Cellulose