Development of organs and intestinal mucosa leukocytes in four broiler lines that differ in susceptibility to malabsorption syndrome.
Growth retardation in young broiler chicks due to poor nutrient metabolism, commonly known as malabsorption syndrome (MAS), is a widespread problem caused by enteric infections with a combination of pathogens mainly viruses. Genetic lines of broiler chickens differ in susceptibility to the syndrome. A difference in growth retardation was observed among four broiler lines (BL) after oral inoculation at 1 d of age with intestinal homogenates obtained from MAS-affected birds. Two of the lines that are more susceptible to MAS had severe weight gain depression. To uncover the factors that play a role in the susceptibility to MAS, we analyzed the growth rate of the body and vital organs and the quantity of leukocytes in the peripheral blood and intestinal mucosa. The development of the intestine, liver, bursa of Fabricius, and spleen was similar among the BL. The resistant BL had higher numbers of peripheral blood leukocytes, especially lymphocytes, at 1 d of age. A significant difference was noted in the numbers of CD4+ T cells and CD8+ T cells in the intestinal villi. At the ages of 3 and 8 d, the susceptible BL had more CD8+ T cells in the villi, whereas the ratios of CD4+:CD8+ T cells were higher in the resistant BL. This difference in the number of T-cell subpopulations in the intestinal mucosa might be an important factor in the difference in susceptibility to the enteric infections associated with MAS.
Zekarias
B
B
Institute for Animal Science and Health, ID-Lelystad, The Netherlands. B.Zekarias@id.wag-ur.nl
Songserm
T
T
Post
J
J
Kok
G L
GL
Pol
J M A
JM
Engel
B
B
ter
Huurne A A H M
HA
D000818:Animals; D001835:Body Weight; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D002645:Chickens; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006128:Growth; D007413:Intestinal Mucosa / Q000473:pathology*; D007962:Leukocytes / Q000473:pathology*; D018655:Lymphocyte Count; D008264:Macrophages / Q000473:pathology; D008286:Malabsorption Syndromes / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000235:genetics* / Q000473:pathology; D013045:Species Specificity