[Hormonal regulation of calcium metabolism in chronic alcoholic pancreatitis].
The purpose of this investigation is to study the state of Ca regulation mechanism at chronic alcohol pancreatitis and to compare with the activity changes of pancreatic lipase and its inhibitor at this disease. Content of Ca and regulating hormones (parathormone and calcitonin), activity of pancreas lipase and inhibitory blood ability in connection with it were determined in 30 patients with chronic alcohol pancreatitis without complications and in 20 persons with complicated disease course. Ca blood content fluctuates within normal level. But the median Ca contents in the group of patients with complications were significantly higher than in the control group. No changes in the level of pathormones and the increased Ca content were observed in the blood of the patients. The direct correlation between Ca and calcitonin and inverse correlation between Ca and parathormone were kept. According to correlation analysis of definite indexes the regulatory mechanisms of Ca metabolism in patients were intact. The increased calcitonin blood content in patients with chronic alcohol pancreatitis has apparently a compensatory character. This fact is confirmed by direct correlation with inhibitory ability of blood with respect to lipase.
Astaf'eva
O V
OV
Vinokurova
L V
LV
Petrakov
A V
AV
Banifatov
P V
PV
D000328:Adult; D002118:Calcium / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology; D019512:Pancreatitis, Alcoholic / Q000201:enzymology / Q000378:metabolism*
D008049:Lipase; D002118:Calcium