title: Buffer administration during CPR promotes cerebral reperfusion after return of spontaneous circulation and mitigates post-resuscitation cerebral acidosis.
abstract: To explore the effects of alkaline buffers on cerebral perfusion and cerebral acidosis during and after cardiopulmonary resuscitation (CPR), 45 anaesthetized piglets were studied. The animals were subjected to 5 min non-interventional circulatory arrest followed by 7 min closed chest CPR and received either 1 mmol/kg of sodium bicarbonate, 1 mmol/kg of tris buffer mixture, or the same volume of saline (n=15 in all groups), adrenaline (epinephrine) boluses and finally external defibrillatory shocks. Systemic haemodynamic variables, cerebral cortical blood flow, arterial, mixed venous, and internal jugular bulb blood acid-base status and blood gases as well as cerebral tissue pH and PCO(2) were monitored. Cerebral tissue acidosis was recorded much earlier than arterial acidaemia. After restoration of spontaneous circulation, during and after temporary arterial hypotension, pH in internal jugular bulb blood and in cerebral tissue as well as cerebral cortical blood flow was lower after saline than in animals receiving alkaline buffer. Buffer administration during CPR promoted cerebral cortical reperfusion and mitigated subsequent post-resuscitation cerebral acidosis during lower blood pressure and flow in the reperfusion phase. The arterial alkalosis often noticed during CPR after the administration of alkaline buffers was caused by low systemic blood flow, which also results in poor outcome.
authors.affiliation: Uppsala University Hospital, Department of Surgical Sciences/Anesthesiology and Intensive Care, SE-751 85 Uppsala, Sweden.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.forename: Ala
authors.initials: A
authors.lastname: Nozari
authors.forename: Sten
authors.initials: S
authors.lastname: Rubertsson
authors.forename: Lars
authors.initials: L
authors.lastname: Wiklund
mesh_terms: D000138:Acidosis / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage; D001921:Brain / Q000378:metabolism*; D002021:Buffers; D002245:Carbon Dioxide / Q000097:blood / Q000378:metabolism; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006863:Hydrogen-Ion Concentration; D007552:Isotonic Solutions / Q000008:administration & dosage; D017693:Sodium Bicarbonate / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D034421:Sus scrofa; D014325:Tromethamine / Q000008:administration & dosage
chemical_list: D001639:Bicarbonates; D002021:Buffers; D007552:Isotonic Solutions; D014325:Tromethamine; C091201:Tribonate; D002245:Carbon Dioxide; D012965:Sodium Chloride; D017693:Sodium Bicarbonate