title: A hybrid mock circulatory system: testing a prototype under physiologic and pathological conditions.
abstract: Hydraulic models of circulation are used to test mechanical heart assist devices and for research and training purposes. However, when compared with numerical models, they are rather expensive and often not sufficiently flexible or accurate. Flexibility and accuracy can be improved by merging numerical models with physical models, thus obtaining a hybrid model where numerical and physical sections are connected by an electrohydraulic interface. This concept is applied here to represent left ventricular function. The resulting hybrid model is inserted into the existing closed loop model of circulation. The hybrid model reproduces ventricular function by a variable elastance numerical model. Its interaction with the hydraulic sections is governed by measuring left atrial and systemic arterial pressures and computing the left ventricular output flow by the resolution of the corresponding equations. This signal is used to control a flow generator reproduced by a gear pump driven by a DC motor. Results obtained under different circulatory conditions demonstrate the behavior of the ventricular model on the pressure-volume plane and report the trend of the main hemodynamic variables.
authors.affiliation: Institute of Biomedical Technologies, CNR, Rome, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ferrari
authors.forename: Claudio
authors.initials: C
authors.lastname: De Lazzari
authors.forename: Maciej
authors.initials: M
authors.lastname: Kozarski
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Clemente
authors.forename: Krystyna
authors.initials: K
authors.lastname: Górczyńska
authors.forename: Rita
authors.initials: R
authors.lastname: Mimmo
authors.forename: Eliana
authors.initials: E
authors.lastname: Monnanni
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Tosti
authors.forename: Marco
authors.initials: M
authors.lastname: Guaragno
mesh_terms: D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008955:Models, Cardiovascular; D011652:Pulmonary Circulation / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology