title: Nicorandil associated anal ulceration.
abstract: Nicorandil is a vasodilator used to control angina. It has been associated with oral ulceration and stomatitis that resolves upon withdrawal of the drug. We report a series of five patients with non-specific anal ulceration, all of whom received nicorandil for symptomatic control of ischaemic heart disease. Histological appearances were similar and the ulcers healed on withdrawal of the drug. Our results suggest that nicorandil might be a cause of anal ulceration.
authors.affiliation: Department of Surgery, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK. a.j.watson@abdn.ac.uk
authors.forename: Angus
authors.initials: A
authors.lastname: Watson
authors.forename: Ous
authors.initials: O
authors.lastname: Al-Ozairi
authors.forename: Andy
authors.initials: A
authors.lastname: Fraser
authors.forename: Malcolm
authors.initials: M
authors.lastname: Loudon
authors.forename: Terry
authors.initials: T
authors.lastname: O'Kelly
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005401:Fissure in Ano / Q000139:chemically induced*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy; D020108:Nicorandil / Q000009:adverse effects*; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D020108:Nicorandil