Passive immunization against nicotine attenuates nicotine discrimination.
Ten rats were trained in a two lever operant chamber to press different levers after a nicotine injection (0.14 mg/kg s.c.) or a saline injection on an FR10 schedule. The rats were then injected i.p. with either 150 mg nicotine-specific IgG or the same amount of control IgG from non-immunized rabbits. On successive days, they were retested with both levers active after a saline injection, a full training dose of nicotine and a half dose of nicotine (0.07 mg/kg s.c.). After saline injection, both groups pressed the saline lever almost exclusively. After each of the nicotine doses, the immunized rats performed a significantly lower percentage of their lever presses on the nicotine lever than did non-immunized rats. The results suggest that passive immunization can interfere with the stimulus properties of nicotine.
Malin
David H
DH
University of Houston-Clear Lake, TX 77058, USA. malin@cl.uh.edu
Alvarado
Candice L
CL
Woodhouse
Katherine S
KS
Karp
Hilary
H
Urdiales
Evelyn
E
Lay
Diana
D
Appleby
Phillip
P
Moon
William D
WD
Ennifar
Sofiane
S
Basham
Lisa
L
Fattom
Ali
A
D000818:Animals; D001522:Behavior, Animal; D003213:Conditioning, Psychological; D003463:Cues; D004193:Discrimination Learning; D005260:Female; D007116:Immunization, Passive; D008297:Male; D009538:Nicotine / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012965:Sodium Chloride
D012965:Sodium Chloride; D009538:Nicotine