Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.
Reynolds
James N
JN
Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada.
Bennett
Brian M
BM
Boegman
Roland J
RJ
Jhamandas
Khem
K
Ratz
Jodan D
JD
Zavorin
Sergei I
SI
Scutaru
Dan
D
Dumitrascu
Adina
A
Thatcher
Gregory R J
GR
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D006152:Cyclic GMP / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006162:Guanylate Cyclase / Q000378:metabolism; D066298:In Vitro Techniques; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy / Q000473:pathology; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009566:Nitrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology
C420322:GT 715; D018696:Neuroprotective Agents; D009566:Nitrates; D014665:Vasodilator Agents; D006162:Guanylate Cyclase; D005996:Nitroglycerin; D006152:Cyclic GMP; D011407:Propane