title: Studies on some feed additives giving partial protection against ochratoxin A toxicity in chicks.
abstract: Significant protective effects of the feed additives: water extract of artichoke, sesame seed, Roxazyme-G and L-beta phenylalanine against the growth inhibitory effect of ochratoxin A (OTA) and associated pathomorphological changes were seen. Similarly, there was less OTA-induced decrease in serum total protein and increase of serum creatinine and urea in the chicks. Whereas OTA induced strong degenerative changes and an increase in weight of kidneys and liver as well as a decrease of the weight of lymphoid organs the additives variously gave protection against these changes. The protection of Roxazyme-G and sesame seed was better expressed in kidneys and liver, whereas the phenylalanine better protected the weight changes in gizzard, heart and the changes in differential WBC count. Notably, sesame seed gave strong protection against 5 ppm OTA-induced suppression of humoral immune response, for which artichoke also had some beneficial effect, whereas phenylalanine had hardly any effect.
authors.affiliation: Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Thracian University, Students Campus, 6000, Stara Zagora, Bulgaria. stoev@uni-sz.bg
authors.forename: Stoycho D
authors.initials: SD
authors.lastname: Stoev
authors.forename: Dimcho
authors.initials: D
authors.lastname: Djuvinov
authors.forename: Teodora
authors.initials: T
authors.lastname: Mirtcheva
authors.forename: Dimitar
authors.initials: D
authors.lastname: Pavlov
authors.forename: Peter
authors.initials: P
authors.lastname: Mantle
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000378:metabolism / Q000633:toxicity*; D002645:Chickens / Q000254:growth & development / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000378:metabolism / Q000494:pharmacology; D006651:Histocytochemistry / Q000662:veterinary; D009097:Multienzyme Complexes / Q000378:metabolism / Q000494:pharmacology; D009793:Ochratoxins / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010649:Phenylalanine / Q000378:metabolism / Q000494:pharmacology; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology*; D012715:Sesame Oil / Q000378:metabolism / Q000494:pharmacology; D013047:Specific Pathogen-Free Organisms; D014675:Vegetables / Q000378:metabolism
chemical_list: D002121:Calcium Channel Blockers; D009097:Multienzyme Complexes; D009793:Ochratoxins; D010936:Plant Extracts; C025589:ochratoxin A; D010649:Phenylalanine; D012715:Sesame Oil; D006026:Glycoside Hydrolases; C095380:Roxazyme G