title: Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
abstract: Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.
authors.affiliation: Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada.
authors.forename: James N
authors.initials: JN
authors.lastname: Reynolds
authors.forename: Brian M
authors.initials: BM
authors.lastname: Bennett
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Boegman
authors.forename: Khem
authors.initials: K
authors.lastname: Jhamandas
authors.forename: Jodan D
authors.initials: JD
authors.lastname: Ratz
authors.forename: Sergei I
authors.initials: SI
authors.lastname: Zavorin
authors.forename: Dan
authors.initials: D
authors.lastname: Scutaru
authors.forename: Adina
authors.initials: A
authors.lastname: Dumitrascu
authors.forename: Gregory R J
authors.initials: GR
authors.lastname: Thatcher
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D006152:Cyclic GMP / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006162:Guanylate Cyclase / Q000378:metabolism; D066298:In Vitro Techniques; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy / Q000473:pathology; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009566:Nitrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: C420322:GT 715; D018696:Neuroprotective Agents; D009566:Nitrates; D014665:Vasodilator Agents; D006162:Guanylate Cyclase; D005996:Nitroglycerin; D006152:Cyclic GMP; D011407:Propane