[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants].
OBJECTIVE
To investigate the role of hepatitis B virus (HBV) DNA levels in HBV-carrier mother and selective transmission of HBV variant with S gene mutation to infant in the failure of neonatal HBV immunization.


METHODS
Serum HBV DNA level was determined by Roche LightCycler quantities in 95 HBsAg-positive pregnant women and later in their newborns. Hepatitis B virus S gene sequences isolated from mother/child pairs were analyzed in 7 cases which did not respond to HBV vaccination and hepatitis B immunoglobulin.


RESULTS
HBV infection was identified in 7.4 % of the infants during their first year after birth. The levels of HBV DNA in the mothers of the infected infants were higher than those of the uninfected group, and selective transmission of HBV variant from mother to infant was observed.


CONCLUSIONS
HBV DNA levels in HBV-carrier mother and selective transmission of HBV variant from mother to infant contribute to the failure of neonatal HBV immunization.
Zhang
Jin
J
Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Wang
Zhan-hui
ZH
Hou
Jin-lin
JL
Yang
Hong
H
Cheng
Ai-lin
AL
Li
Xiu-hui
XH
D000328:Adult; D002353:Carrier State / Q000635:transmission / Q000821:virology; D004279:DNA, Viral / Q000097:blood / Q000737:chemistry; D005260:Female; D014644:Genetic Variation; D006509:Hepatitis B / Q000097:blood / Q000517:prevention & control / Q000635:transmission*; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D009154:Mutation; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D017422:Sequence Analysis, DNA; D014611:Vaccination
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines