title: No association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia.
abstract: Genetic components are involved in the aetiology of schizophrenia. Activating Protein 2 (AP-2) transcription factors are essential for neural gene expression and neural development. Transcription factor AP-2beta has also been connected with monoaminergic genes and monoamine levels in various brain regions. Thus, the AP-2beta gene is a suitable candidate taking both the neurodevelopmental and dopamine hypotheses of schizophrenia into account. We investigated 135 schizophrenic patients and 382 control subjects with regard to an intronic AP-2beta variant without evidence of any association. We conclude that the investigated AP-2beta variant is not of major importance to schizophrenia in the investigated Swedish population.
authors.affiliation: Department of Clinical Neuroscience, HUBIN project, Psychiatry Section, Karolinska Institute and Hospital, SE-171 76 Stockholm, Sweden. erikj@ks.se
authors.forename: Erik G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: Mattias
authors.initials: M
authors.lastname: Damberg
authors.forename: Kaj
authors.initials: K
authors.lastname: Forslund
authors.forename: Marja
authors.initials: M
authors.lastname: Mattila-Evenden
authors.forename: Gunnar
authors.initials: G
authors.lastname: Rylander
authors.forename: Marie
authors.initials: M
authors.lastname: Asberg
authors.forename: Lars
authors.initials: L
authors.lastname: Oreland
authors.forename: Göran C
authors.initials: GC
authors.lastname: Sedvall
mesh_terms: D000328:Adult; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D013548:Sweden; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*; D044465:White People
chemical_list: D004268:DNA-Binding Proteins; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; D014157:Transcription Factors