DNA arrays as diagnostic tools in human healthcare.
The sequencing of the entire human genome was completed in June 2000. The sequence, however, is only a starting point and gene-function is now of major interest. All this information shows that gene-based diagnostics can be helpful for treatment targeting and patient surveillance. High volume gene expression assays can optimize pharmaceutical therapies by targeting genome-based treatments to specific patient populations and providing methods to study genes involved with cancer growth patterns and tumor suppression. Molecular biology, so far, has elucidated many of the genetic mechanisms underlying heritable metabolic diseases, so that appropriate diagnostic assays will revolutionize molecular diagnostics in medicine and pharmaceuticals. One of the most promising new technologies designed to analyze large amounts of genomic information rapidly is the DNA chip.
Toder
Roland
R
R. Toder Consulting, Oleweg 7, D-79279 Vorstetten, Germany. srtroder@gmx.de
D001709:Biotechnology / Q000379:methods*; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics; D005821:Genetic Techniques; D015894:Genome, Human; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D025202:Molecular Diagnostic Techniques; D015997:Neonatal Screening; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation* / Q000379:methods*
D006680:HLA Antigens