title: Synthesis of BF2 chelates of tetraarylazadipyrromethenes and evidence for their photodynamic therapeutic behaviour.
abstract: The synthesis, spectroscopic characteristics and in vitro cellular uptake properties of a new class of therapeutic window photosensitiser, namely the BF2 chelates of 3,5-diaryl-1H-pyrrol-2-yl-3,5-diarylpyrrol-2-ylidene amines (tetra-arylazadipyrromethenes), are described with the aim of developing a novel class of photodynamic therapeutic agents.
authors.affiliation: Centre for Synthesis and Chemical Biology, Conway Institute, Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: John
authors.initials: J
authors.lastname: Killoran
authors.forename: Lorcan
authors.initials: L
authors.lastname: Allen
authors.forename: John F
authors.initials: JF
authors.lastname: Gallagher
authors.forename: William M
authors.initials: WM
authors.lastname: Gallagher
authors.forename: Donal F
authors.initials: DF
authors.lastname: O'Shea
mesh_terms: D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010778:Photochemotherapy / Q000379:methods*; D013053:Spectrophotometry; D013997:Time Factors
chemical_list: D006575:Heterocyclic Compounds, 3-Ring