title: How laminin-1 can be recognized by the protozoan parasite Tritrichomonas foetus: possible role played by the extracellular matrix glycoprotein in both cytoadhesion and cytotoxicity exerted by the parasite.
abstract: The isoform 1 of the extracellular matrix glycoprotein Laminin is known to be an important ligand for some parasitic protozoa including Trichomonas vaginalis. The bovine parasite Tritrichomonas foetus seems to display a similar recognition process to laminin-1, as some amino acid sequences found in the LNS module of laminin-1 can also be recognized by this parasite. Which of the laminin-1 residing adhesion sequences are recognized by T. foetus, and the role played by such a protein-cell recognition process in both cytoadhesion and cytotoxicity exerted by the parasite are the subjects briefly reviewed and discussed here.
authors.affiliation: UFRJ-Instituto de Biofísica Carlos Chagas Filho, CCS-Bloco G, 21949-900, Rio de Janeiro, Brazil. fcsf@biof.ufrj.br
authors.forename: F C
authors.initials: FC
authors.lastname: Silva-Filho
authors.forename: S
authors.initials: S
authors.lastname: Kasai
authors.forename: M
authors.initials: M
authors.lastname: Nomizu
authors.forename: L B
authors.initials: LB
authors.lastname: López
authors.forename: M B
authors.initials: MB
authors.lastname: Melo-Braga
authors.forename: B
authors.initials: B
authors.lastname: Rocha-Azevedo
authors.forename: D B
authors.initials: DB
authors.lastname: Petrópolis
authors.forename: I S
authors.initials: IS
authors.lastname: Horbach
mesh_terms: D000818:Animals; D002417:Cattle; D002448:Cell Adhesion; D005109:Extracellular Matrix / Q000737:chemistry; D005260:Female; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D008297:Male; D011528:Protozoan Infections / Q000469:parasitology; D016835:Tritrichomonas foetus / Q000472:pathogenicity* / Q000502:physiology*; D014774:Virulence
chemical_list: D007797:Laminin; C121346:laminin 1