title: The role of heat shock proteins in mammalian differentiation and development.
abstract: Heat shock proteins (HSPs) have been identified in all cells, prokaryotic and eukaryotic, to protect the cells from harmful insults and stress. Increased HSP synthesis can also result during normal cellular functions and also respond to exposure from environmental stress and infection. Although the molecular mechanisms responsible for HSP cellular protection are still not fully understood, their expression is critical for cellular survival and can be modified by cell signal transducers such as intracellular pH, cyclic AMP, Ca2+ Na+, inositol [correction of inostitol] triphosphate, protein kinase C, and protein phosphates. Most HSPs interact, assemble, fold, unfold, bind, transport, translocate and 'chaperone' other proteins in the cell and alter their function.
authors.affiliation: School of Anatomy, Department of Medicine, The University of New South Wales, Sydney, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Walsh
authors.forename: J
authors.initials: J
authors.lastname: Grantham
authors.forename: X O
authors.initials: XO
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Wei Lin
authors.forename: M
authors.initials: M
authors.lastname: van Oosterum
authors.forename: R
authors.initials: R
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Edwards
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle; D002454:Cell Differentiation / Q000502:physiology; D002490:Central Nervous System / Q000002:abnormalities / Q000254:growth & development*; D019465:Craniofacial Abnormalities / Q000209:etiology; D005260:Female; D005334:Fever / Q000378:metabolism* / Q000503:physiopathology; D018507:Gene Expression Regulation, Developmental; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006358:Hot Temperature / Q000009:adverse effects*; D018832:Molecular Chaperones / Q000235:genetics / Q000502:physiology; D011247:Pregnancy; D015398:Signal Transduction
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones