Polymyositis: clinical investigation in two sisters.
We present an investigation of a case of polymyositis affecting two sisters of one same parenthood. Their cases have been documented for almost two decades, being investigated by means of a diagnostic protocol which combined clinical findings as well as laboratorial, histopathological and image tests. In both cases, clinical manifestations started in childhood, without signs of involvement of the central and peripheral nervous system. Both patients proved to respond to a therapeutics based on corticosteroids. The degree of relatedness between their parents corroborate the notion that genetic factors may contribute to the development of the disease.
Karnikowski
Margô Gomes de Oliveira
MG
Department of Physiotherapy, Catholic University of Brasilia, Brasilia, DF, Brasil.
Costa
Bruno Rodrigues Veloso
BR
Osella
Oscar Francisco Sanchez
OF
Nóbrega
Otávio Tolêdo
OT
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006801:Humans; D008297:Male; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D017285:Polymyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D035781:Siblings
D000305:Adrenal Cortex Hormones; D005634:Fructose-Bisphosphate Aldolase