The influence of age on gender differences in depression: further population-based evidence on the relationship between menopause and the sex difference in depression.
OBJECTIVE
This study tests the hypothesis that gender differences in depression diminish after menopause (around the age of 55). Methods Using the 1994 National Population Health Survey, we examine the relationship between age and gender on major depressive disorder in relation to sociodemographic and social covariates using contingency table analyses and multivariate logistic regression.


RESULTS
Contingency table and multivariate analyses identify significantly higher rates of depression among women before and after the age period associated with menopause. A series of multivariate analyses controlling for a broad array of social factors also does not lead to any convergence in differences of rates of depression between males and females. Hormone replacement therapy (HRT) does not have a significant impact on these observed relationships.


CONCLUSIONS
These findings are at odds with a recent study that has identified menopause as a point where gender differences in depression diminish. Further research is required to address this inconsistency.
Cairney
John
J
Department of Psychiatry and Behavioural Neuroscience, McMaster University, Patterson Building - Chedoke Site, 1200 Main St West, Hamilton, ON, L8N 3Z5 Canada. cairnej@mcmaster.ca
Wade
Terrance J
TJ
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002170:Canada / Q000453:epidemiology; D002391:Catchment Area, Health; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000523:psychology; D008875:Middle Aged; D011159:Population Surveillance; D017678:Sex Distribution