title: Tandem enzyme-catalysed oxidations of alkyl phenyl sulfides and alkyl benzenes: enantiocomplementary routes to chiral phenols.
abstract: Dioxygenase-catalysed trioxygenation of alkyl phenyl sulfides and alkyl benzenes yields enantiopure cis-dihydrodiol sulfoxides and triols respectively; naphthalene cis-dihydrodiol dehydrogenase-catalysed aromatisation of these diastereoisomers gives enantiopure catechols of either configuration.
authors.affiliation: School of Chemistry, Queen's University of Belfast, Belfast, UK BT9 5AG. dr.boyd@qub.ac.uk
authors.forename: Derek R
authors.initials: DR
authors.lastname: Boyd
authors.forename: Narain D
authors.initials: ND
authors.lastname: Sharma
authors.forename: Vera
authors.initials: V
authors.lastname: Ljubez
authors.forename: Breige E
authors.initials: BE
authors.lastname: Byrne
authors.forename: Steven D
authors.initials: SD
authors.lastname: Shepherd
authors.forename: Christopher C R
authors.initials: CC
authors.lastname: Allen
authors.forename: Leonid A
authors.initials: LA
authors.lastname: Kulakov
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Larkin
authors.forename: Howard
authors.initials: H
authors.lastname: Dalton
mesh_terms: D001554:Benzene / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D002396:Catechols / Q000737:chemistry* / Q000378:metabolism*; D007536:Isomerism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism*; D013440:Sulfides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002396:Catechols; D013440:Sulfides; D010088:Oxidoreductases; D010105:Oxygenases; D001554:Benzene