[Methods of determination of fluoxetine nad fluvoxamine].
Two selective serotonin reuptake inhibitors (SSRIs) have been introduced: fluoxetine and fluvoxamine. The literature review shows most methods allow quantitative determination of SSRIs pharmaceutical preparations and plasma, in the lower ng/ml range and that they are, therefore, suitable for therapeutic drug monitoring purposes of this category of drugs. Most procedures are based on investigation of this drugs by spectrophotometric, electrochemical and chromatographic procedures with detection by various detectors.
Starczewska
Barbara
B
Zakładu Chemii Ogólnej i Nieorganicznej Uniwersytetu w Białymstoku.
Mielech
Katarzyna
K
Kleszczewska
Ewa
E
D018687:Antidepressive Agents, Second-Generation; D016903:Drug Monitoring / Q000379:methods*; D005473:Fluoxetine / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D016666:Fluvoxamine / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017367:Selective Serotonin Reuptake Inhibitors / Q000097:blood / Q000737:chemistry / Q000378:metabolism
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors