Assessment of the neurogenic flare reaction in small-fiber neuropathies.
To improve sensitivity of the analysis of axon reflex flare reaction, the authors used a laser Doppler scanner and analyzed flare intensity and size induced by histamine iontophoresis simultaneously at the foot and thigh in patients with small-fiber neuropathy (n = 10) and controls (n = 9). Flare size, but not laser Doppler flux, clearly distinguished patients from controls at both locations (p < 0.01) and may be useful for evaluation of small-fiber neuropathies.
Bickel
A
A
Department of Neurology, University Erlangen-Nuremberg, Erlangen, Germany. andreas.bickel.med.uni-erlangen.de
Krämer
H H
HH
Hilz
M J
MJ
Birklein
F
F
Neundörfer
B
B
Schmelz
M
M
D000368:Aged; D001369:Axons / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D020078:Neurogenic Inflammation / Q000175:diagnosis*; D010523:Peripheral Nervous System Diseases / Q000473:pathology; D012018:Reflex