Relationship between personality trait and regional cerebral glucose metabolism assessed with positron emission tomography.
There have been no studies systematically investigating relationships between biogenetic temperament dimensions and patterns of brain glucose metabolism. Nineteen healthy subjects were evaluated regarding the biogenetic temperament using Cloninger's Temperament and Character Inventory (TCI). In addition, [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET) was used to measure regional brain glucose metabolism. Voxel-based correlation analysis was used to test correlations between regional brain glucose metabolism and scores on the TCI. We identified that each temperament dimension, such as Novelty Seeking, Harm Avoidance, and Reward Dependence, was significantly correlated with specific brain regions. The majority of correlations were observed in the areas of paralimbic regions and temporal lobes. The current study provides evidence linking each biogenetic temperament dimension with specific brain areas and provides a promising base for future personality research.
Youn
Tak
T
Department of Psychiatry, Seoul National University College of Medicine and Hospital, 28 Yongun-dong, Chongno-gu, 110-744, Seoul, Republic of Korea.
Lyoo
In Kyoon
IK
Kim
Jae-Kim
JK
Park
Hae-Jeong
HJ
Ha
Kyoo-Seob
KS
Lee
Dong Soo
DS
Abrams
Kelley Yost
KY
Lee
Myung Chul
MC
Kwon
Jun Soo
JS
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D010551:Personality / Q000502:physiology*; D010555:Personality Inventory; D013694:Temperament / Q000502:physiology*; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18