Tuberculosis control priorities defined by using cost-effectiveness and burden of disease.
OBJECTIVE
To define TB control priorities using cost-effectiveness and burden of disease.


METHODS
An assumed cohort of 2,000 cases was set up based on age-specific incidence of 794 newly registered smear-positive cases in Beijing in 1994. Prognostic trees and model diagrams of infectivity with natural history and DOTS intervention were constructed based on the epidemiological parameters.


RESULTS
DOTS reduced 89.19% of YLL, 78.90% of YLD, and 99.98% of infectivity BOD. One DALY could be saved with 45.70 Yuan by DOTS with 3% discount. Sensitivity analysis showed that discount had effect on CER. Weight of age was insensitive to CER. The higher the DOTS cured rate, the more the cost-effectiveness.


CONCLUSIONS
DOTS is a good cost-effectiveness TB control strategy. Cost-effectiveness and burden of disease can be used to define TB control priorities.
Xu
Qun
Q
Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Wu
Zheng-Lai
ZL
Jin
Shui-Gao
SG
Zhang
Li-Xing
LX
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D006233:Persons with Disabilities; D005544:Forecasting; D006801:Humans; D008875:Middle Aged; D008954:Models, Biological; D019057:Quality-Adjusted Life Years; D014376:Tuberculosis / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*