Comparative study of the efficacy of topical corticosteroid: five locally made and one brand name creams.
The aim of this study was to evaluate the efficacy of 5 locally made clobetasol propionate creams compared with a brand name product. The study was divided into 3 parts 1) pharmacological study, 2) vasoconstriction test, and 3) double blind clinical trial. The results showed that the pharmacological properties of the locally made products were not different from the brand name product. Product C and D could diffuse through cellulose acetate membrane 3 fold more than the brand name product. Product D and E caused less vasoconstriction than the brand name product. This double blind study showed that all locally made products could improve psoriasis to the same extent as the brand name product, but there was more recurrence of psoriasis while using all the locally made products. It was concluded that locally made products were as effective as the brand name product in the treatment of psoriasis evaluated over a 2 week peroid, but more recurrence was observed with locally made products.
Puavilai
Siripen
S
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Krisadaphong
Panwipa
P
Leenutaphong
Vichit
V
Asawanonda
Pravit
P
Akaraphan
Rutsanee
R
Ploysangham
Tanusin
T
Ruangkarnchanasetr
Suwanna
S
Noppakun
Nopadon
N
Charuwichitratana
Somyot
S
Kulthanan
Kanokvalai
K
Huiprasert
Porntip
P
Tresukosol
Poohglin
P
Ophaswongse
Suwirakorn
S
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002990:Clobetasol / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016568:Drugs, Generic / Q000008:administration & dosage* / Q000627:therapeutic use*; D005938:Glucocorticoids; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D016568:Drugs, Generic; D005938:Glucocorticoids; D002990:Clobetasol