Theoretical approach to description of time-dependent nitric oxide effects in the vasculature.
Nitric oxide (NO) is one of the most important signal compounds in a living cell. As a typical free radical it has both toxic and physiological effects and their balance is determined by a spatial distribution of NO concentration. Moreover, some biological functions, especially NO-mediated relaxation of blood vessels, have to be time-limited. In order to circumscribe this phenomenon non steady-state mathematical model has been used for description of nitric oxide diffusion in vascular smooth muscle. It was shown that the microvascular relaxation could be observed even after a short time of NO production in the endothelium. This time is up to 3 times below that needed to reach the steady-state spatial NO gradient. However, the effect of nitric oxide essentially depends on the rate of NO production and blood vessel diameter. Furthermore, non steady-state nitric oxide concentration gradient was represented as an analytical function of time and coordinate. It is essential that this function describes a common case of one-dimensional diffusion of uncharged low-mass molecules. Thus, the results can be used for calculation of an upper estimation of experimental data.
Seraya
I P
IP
Institute of cytochemistry and molecular pharmacology, Moscow, Russia. yarosl@biotic.dol.ru
Nartsissov
Ya R
YR
D001808:Blood Vessels / Q000378:metabolism* / Q000502:physiology; D004058:Diffusion; D004730:Endothelium, Vascular / Q000378:metabolism; D008433:Mathematics; D008955:Models, Cardiovascular; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D013997:Time Factors
D009569:Nitric Oxide