title: Spectrum of inherited bleeding disorders from Western India.
abstract: OBJECTIVE
  The study was undertaken to assess the magnitude and diversity of different bleeding disorders in Western India.
  
  
  METHODS
  768 cases referred to our Institute for evaluation of an underlying bleeding diathesis were investigated appropriately to detect the cause of the abnormal hemostatic function.
  
  
  RESULTS
  630 patients were diagnosed to have hereditary bleeding diathesis. Amongst these, 598 patients had a coagulation disorder while only 32 patients had a platelet function abnormality. Amongst the coagulation disorders, hemophilia A (70.5%) was the most common disorder followed by hemophilia B (14%) and VWD (10.8%). Glanzman's thrombasthenia (84.3%) was the most common platelet function disorder followed by Bernard-Soulier syndrome (12.5%). Some rare disorders have also been diagnosed.
  
  
  CONCLUSIONS
  In spite of their apparent rarity, India has a substantial number of cases of inherited bleeding disorders. A large number of these patients is referred to many tertiary care institutions. It is therefore desirable that district hospitals must develop their laboratories to detect most of these disorders so that the patients need not travel long distances to get an appropriate diagnosis and proper management. All 1st degree female relatives of severe and moderate hemophilia must get factor assays done because some of them may be vulnerable to post-procedural or post-traumatic bleeding.
authors.affiliation: Institute of Immunohematology, K.E.M. Hospital Campus, Parel, Mumbai, India.
authors.forename: M
authors.initials: M
authors.lastname: Manisha
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
authors.forename: S
authors.initials: S
authors.lastname: Shetty
authors.forename: S
authors.initials: S
authors.lastname: Nair
authors.forename: A
authors.initials: A
authors.lastname: Khare
authors.forename: B
authors.initials: B
authors.lastname: Kulkarni
authors.forename: A V
authors.initials: AV
authors.lastname: Pathare
authors.forename: S
authors.initials: S
authors.lastname: Baindur
authors.forename: D
authors.initials: D
authors.lastname: Mohanty
mesh_terms: D025861:Blood Coagulation Disorders, Inherited / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology*; D001791:Blood Platelet Disorders / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology*; D020147:Coagulation Protein Disorders / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male