[Sucessful treatment with clofazimine and itraconazole in a 46 year old patient after 32 years duration of disease].
Lobomycosis, caused by the fungal pathogen Lacazia loboi, is a chronic deep mycosis and is only found in Central and South America. Clinically the disease is characterized by shiny keloidal nodules appearing mainly on the exposed parts such as face and the upper and lower extremities. Therapeutically the surgical removal of the lesions is considered as the only successful treatment. We describe the therapeutic response of a patient with Lobo's disease treated for one year with a combination of clofazimine (100 mg/day) and itraconazole (100 mg/day). A complete clinical and histopathological remission of the disease was observed. The patient has been followed for three years.
Fischer
M
M
Abteilung für Dermatologie, Bundeswehrkrankenhaus Hamburg, Germany.
Chrusciak Talhari
A
A
Reinel
D
D
Talhari
S
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001759:Blastomycosis / Q000175:diagnosis / Q000188:drug therapy*; D002991:Clofazimine / Q000008:administration & dosage / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D017964:Itraconazole; D002991:Clofazimine