Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy.
Idiopathic dilated cardiomyopathy (IDC) is a distinct disease of the myocardium, of unknown etiology. The disease can occur acutely, or evolve in a subacute fashion. IDC is often associated with a substantial impairment of ventricular function, which may recover over time. Although spontaneous recovery of LV function occurs in 20%-45% of newly diagnosed patients, the majority of patients do not do well. IDC has an average 5-year mortality of 20%. Abnormalities of energetics, perfusion, and adrenergic control of the myocardium are markers of the status of LV dysfunction. As the heart fails, changes occur in the production and catabolism of high-energy substrates, the efficiency of mitochondrial oxidative processes, the distribution of resting perfusion and coronary vasodilating capacity and the adrenergic receptor density and function. This article reviews the information provided by metabolic and receptor imaging in patients with IDC, and the role the data may play in patient management.
Neglia
Danilo
D
Consiglio Nazionale delle Ricerche (CNR), Institute of Clinical Physiology, Pisa, Italy.
Sambuceti
Gianmario
G
Iozzo
Patricia
P
L'Abbate
Antonio
A
Strauss
H William
HW
D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011941:Receptors, Adrenergic / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging / Q000378:metabolism
D005227:Fatty Acids; D019275:Radiopharmaceuticals; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D011976:Receptors, Muscarinic; D019788:Fluorodeoxyglucose F18; D005947:Glucose