[The comparative study of the safety of a vaccinal process in both oral and epicutaneous immunization against smallpox].
Results of comparative studies of tableted and epicutaneous live smallpox vaccines are presented. In experiments on rabbits by using histological, immunofluorescent, immunological and virological methods, higher safety and efficiency of the tableted vaccine than that of traditional smallpox epicutaneous vaccine were determined. The natural and physiological character of oral immunization was shown. The oral immunization was concluded to be a safe method of inoculation now and perspective for the use of recombinant vaccines based on vaccine virus in the absence of population immunity against smallpox.
Bektimirov
T A
TA
Podkuĭko
V N
VN
Grigor'eva
L V
LV
Perekrest
V V
VV
Mikhaĭlov
V V
VV
Tereshkina
N V
NV
Dorokhina
T V
TV
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D004353:Drug Evaluation, Preclinical; D011817:Rabbits; D012899:Smallpox / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D012900:Smallpox Vaccine / Q000008:administration & dosage*; D013607:Tablets; D014611:Vaccination / Q000379:methods*; D014616:Vaccinia virus / Q000276:immunology* / Q000302:isolation & purification
D012900:Smallpox Vaccine; D013607:Tablets