Immune escape through C-type lectins on dendritic cells.
Dendritic cells (DCs) detect different pathogens and elicit tailored anti-microbial immune responses. They express C-type lectins that recognise carbohydrate profiles on microorganisms, resulting in internalisation, processing and presentation. Intracellular sequences of distinct DC-specific lectins point to differences in intracellular routing that influence antigen presentation. Moreover, putative signalling motifs hint to the activation of DCs on carbohydrate recognition. Recent evidence shows that not only pathogens, but also tumour antigens, exploit C-type lectins to escape intracellular degradation resulting in abortive immunity. More insight into ligand specificity, intracellular targeting and signalling will reveal the pathways by which pathogens modulate immunity through C-type lectins.
Engering
Anneke
A
Dept. of Molecular Cell Biology, VU Medical Center, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
Geijtenbeek
Teunis B H
TB
van Kooyk
Yvette
Y
D000818:Animals; D017951:Antigen Presentation; D002241:Carbohydrates / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular; D037102:Lectins / Q000145:classification / Q000276:immunology*; D008024:Ligands; D009369:Neoplasms / Q000276:immunology
D002241:Carbohydrates; D037102:Lectins; D008024:Ligands