Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.
A 1X22X41 combinatorial library or 902 compounds of indinavir analogues was synthesized on the solid support to identify a replacement for the aminoindanol moiety at P2'. 2,6-Dimethyl-4-hydroxy phenol was discovered to be a good replacement for aminoindanol.
Raghavan
Subharekha
S
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. subha_raghavan@merck.com
Yang
Zheng
Z
Mosley
Ralph T
RT
Schleif
William A
WA
Gabryelski
Lori
L
Olsen
David B
DB
Stahlhut
Mark
M
Kuo
Lawrence C
LC
Emini
Emilio A
EA
Chapman
Kevin T
KT
Tata
James R
JR
D020650:Combinatorial Chemistry Techniques; D016333:HIV Protease / Q000737:chemistry / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D019469:Indinavir / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D017320:HIV Protease Inhibitors; D007202:Indicators and Reagents; D019469:Indinavir; D016333:HIV Protease