Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild.
Fatty acids (FA), hydrocarbons, alpha-amyrin, stigmasterol and beta-sitosterol were identified in the n-hexane extract of the aerial parts of Sideritis taurica Stephan ex Wild. Xanthotoxin, as well as 2-acetyl-3-hydroxy-5,6,8-trimethoxy-1,4-naphthoquinone were isolated from the methylene chloride extract of the plant. In addition to apigenin 7-O-beta-D-glucopyranoside and apigenin, previously reported from the plant, hypolaetin 7-O-beta-D-allopyranosyl-O-beta-D-glucopyranoside was isolated from the ethyl acetate extract. From the methanol extract, isoscutellarein 7-O-beta-D-allopyranosyl-O-beta-D-glucopyranoside was also isolated. Toxicity study of petroleum ether extract (f(1)), ethanolic extract (f(2)), dichloromethane fraction of f(2) (f(3)) and n-butanolic fraction of f(2) (f(4)) of the plant proved that it is relatively nontoxic. The tested extracts and fractions exhibited significant analgesic, anti-inflammatory, anti-ulcerogenic and antihyperglycaemic activities, but no anticonvulsant and antipyretic effects, as compared with control groups and reference drugs.
Aboutabl
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EA
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-el-Aini Street, 11562 Cairo, Egypt. eaboutabl@hotmail.com
Nassar
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MI
Elsakhawy
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FM
Maklad
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YA
Osman
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AF
El-Khrisy
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EA
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy / Q000379:methods / Q000706:statistics & numerical data; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D031365:Sideritis / Q000737:chemistry
D010936:Plant Extracts