Discrepancies between brain CT imaging and severely raised intracranial pressure proven by ventriculostomy in adults with pneumococcal meningitis.
OBJECTIVE
Computed tomography (CT) of the brain is recommended for assessment of intracranial pressure (ICP) of patients with acute bacterial meningitis who are comatose or show focal neurological deficits. The aim of this report is to draw attention to the possibility of a discrepancy between CT findings and ICP values in some patients with pneumococcal meningitis.


METHODS
We describe three adult patients with pneumococcal meningitis who had both successive CT examinations and ICP measurements at the time of clinically evident cerebral herniation (n = 2) and/or prolonged coma (n = 2).


RESULTS
Although measurements with a ventriculostomy catheter indicated that all three patients had severely raised ICP values of 90, 44, and 45 mmHg, repeated cranial CT greatly underestimated true ICP values. Despite clinical evidence of acute cerebral herniation, it was not detected in the contemporary CT findings of two patients. Continuous ICP monitoring in the ICU helped to guide treatment for increased ICP; nevertheless, two patients died.


CONCLUSIONS
The clinician must be aware that cranial CT may fail to rule out the possibility of severely raised ICP or cerebral herniation in a patient with pneumococcal meningitis. Therefore, ICP monitoring of patients with bacterial (especially pneumococcal) meningitis who are in prolonged coma should be considered early and regardless of the cranial CT appearances.
Winkler
Frank
F
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany.
Kastenbauer
Stefan
S
Yousry
Tarek A
TA
Maerz
Ulrich
U
Pfister
Hans-W
HW
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D008586:Meningitis, Pneumococcal / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014696:Ventriculostomy / Q000379:methods*