Observations on haematological and cardiovascular effects of erythropoietin treatment in multiple system atrophy with sympathetic failure.
Symptomatic autonomic neuropathy and in particular sympathetic failure mediated postural hypotension often accompanies Multiple System Atrophy (MSA). Release of erythropietin is under sympathetic control and we and others have previously reported that severe autonomic failure may be associated with a normocytic normochromic anaemia and erythopietin (EPO) deficiency. In this paper we describe the haematological, cardiovascular and clinical observations on a patient with MSA and severe symptomatic autonomic neuropathy who had haematological and clinical improvement (substantial increase in standing blood pressure) following subcutaneous EPO treatment.
Winkler
Andrea Sylvia
AS
Regional Movement Disorders and Autonomic Unit, King's College Hospital, Guy's, King's and St. Thomas' Medical School, London, UK.
Landau
Sabine
S
Watkins
Peter
P
Chaudhuri
K Ray
KR
D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D001769:Blood / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000503:physiopathology*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019578:Multiple System Atrophy / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome
D004921:Erythropoietin