High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay.
We describe a high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB*0107 N, in the Angaite Amerindian community in Paraguay. Of the 16 unrelated subjects, 9 (56.5%) had this haplotype. The structural analyses revealed this haplotype was similar to the previously reported Asian haplotype in that they had a large-scale deletion including the entire MICA gene and linked to MICB*0107 N and HLA-B*48. The novel recombination haplotype between this MIC null haplotype and HLA-B15, HLA-B15-MICA-del-MICB*0107 N, was also found in this community.
Aida
Kayano
K
Department of Medical Zoology, Saitama Medical School, Moroyama, Japan.
Russomando
Graciela
G
Kikuchi
Mihoko
M
Candia
Norma
N
Franco
Leticia
L
Almiron
Maria
M
Ubalee
Ratawan
R
Hirayama
Kenji
K
D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D015235:HLA-B Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008297:Male; D010239:Paraguay; D010375:Pedigree; D011995:Recombination, Genetic; D017384:Sequence Deletion
D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen; D004247:DNA