title: Erythromycin inhibits prostaglandin F2alpha-induced contractions of myometrium isolated from non-pregnant rats.
abstract: OBJECTIVE
  The aim of this study was to investigate the effects of erythromycin on prostaglandin F2alpha (PGF2alpha)-induced contractions of isolated myometrial strips from non-pregnant rats.
  
  
  METHODS
  In vitro pharmacological study.
  
  
  METHODS
  Firat University Faculty of Medicine.
  
  
  METHODS
  Myometrium samples were taken from 55 adult Wistar rats.
  
  
  METHODS
  Myometrial strips were isolated from mature, non-pregnant Wistar rats. Isometric contractions of these strips were induced with 1 microM PGF2alpha. Effects of 0.01, 0.1, 0.2, 0.5 and 1 mM erythromycin on the frequency and amplitude of these PGF2alpha-induced contractions were recorded.
  
  
  METHODS
  The inhibition of prostaglandin F2alpha-induced contractions in vitro.
  
  
  RESULTS
  Application of 0.01 mM erythromycin had no effect on either amplitude or frequency of contractions. However, 0.1, 0.2, 0.5 and 1 mM erythromycin decreased the frequency and amplitude of PGF2alpha-induced contractions. The inhibitory effect of erythromycin on amplitude was 27%, 38%, 54% and 83% (P < 0.05), and that on frequency was 10%, 16%, 32% and 61% (P < 0.05) at 0.1, 0.2, 0.5 and 1 mM concentrations, respectively.
  
  
  CONCLUSIONS
  The results of this study demonstrate that erythromycin inhibits PGF2alpha-induced contractions in rat myometrium. Because PGF2alpha-induced contractions have been suggested to be involved in the pathogenesis of primary dysmenorrhoea, effects of erythromycin in this clinical entity may present a new approach for the treatment.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Firat University, Elazig, Turkey.
authors.forename: Husnu
authors.initials: H
authors.lastname: Celik
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ayar
authors.forename: Abdulkerim
authors.initials: A
authors.lastname: Baltaci
authors.forename: Niyazi
authors.initials: N
authors.lastname: Tug
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015237:Dinoprost / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D010120:Oxytocics / Q000037:antagonists & inhibitors*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D010120:Oxytocics; D011500:Protein Synthesis Inhibitors; D004917:Erythromycin; D015237:Dinoprost