Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma.
Neurologic autoimmunity frequently occurs with thymoma, particularly myasthenia gravis and skeletal muscle-specific autoantibodies. Type 1 antineuronal nuclear antibody (ANNA-1/"anti-Hu"), which is recognized as an immunoglobulin G marker of small-cell lung carcinoma, has not been reported with thymoma. The authors identified four patients (three under age 40) with ANNA-1 and a paraneoplastic neurologic complication of thymoma. Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity.
Vernino
Steven
S
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Eggenberger
Eric R
ER
Rogers
Lisa R
LR
Lennon
Vanda A
VA
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000276:immunology* / Q000473:pathology; D013945:Thymoma / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies; C051931:myasthenia gravis anti-skeletal muscle antibody