The eye photoreceptor protein rhodopsin. Structural implications for retinal disease.
Rhodopsin is the membrane receptor responsible for photoreception in the vertebrate retina. Its characteristic seven-transmembrane helical structural motif is today widely recognised as a paradigm in signal transduction. Rhodopsin and the phototransduction system are frequently used as structural and mechanistic models for the G-protein coupled receptor superfamily. Recent advances in the activation mechanism (as derived from the structural available data) and the implications for normal and pathological - in retinal disorders - visual function will be reviewed.
Garriga
Pere
P
Secció de Terrassa, Departament d'Enginyeria Qui;mica, Universitat Politècnica de Catalunya, Colom 1, 08222 Terrassa, Catalonia, Spain. pere.garriga@upc.es
Manyosa
Joan
J
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D009755:Night Blindness / Q000151:congenital / Q000235:genetics / Q000503:physiopathology; D017433:Protein Structure, Secondary; D012164:Retinal Diseases / Q000235:genetics / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000503:physiopathology; D012243:Rhodopsin / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D014785:Vision, Ocular
D012243:Rhodopsin