title: De-acclimatization process of rats acclimatized to high altitude hypoxia.
abstract: The de-acclimatization process in rats acclimatized to high altitude hypoxia was analyzed according to the changes in the activities of hepatic enzymes. The activities of tryptophan 2,3-dioxygenase and tyrosine aminotransferase in the liver of non-acclimatized rats were increased, whereas those of acclimatized rats were decreased after exposure to a simulated altitude of 8,000 m. When the acclimatized rats were kept under normoxic conditions for 8 days and over, the suppression of enzyme induction was nullified, and both enzymes were induced by exposure to the simulated 8,000 m altitude. De-acclimatization of rats acclimatized to hypoxia can be completed in 8-11 days.
authors.affiliation: Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
authors.forename: H
authors.initials: H
authors.lastname: Seo
authors.forename: M
authors.initials: M
authors.lastname: Nakatsuka
authors.forename: M
authors.initials: M
authors.lastname: Yoshino
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000531:Altitude; D000818:Animals; D001273:Atmosphere Exposure Chambers; D000860:Hypoxia / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014366:Tryptophan Oxygenase / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000378:metabolism
chemical_list: D014366:Tryptophan Oxygenase; D014444:Tyrosine Transaminase