3',4'-trans-linked bicyclic nucleosides locked in S-type conformations.
A novel class of 3',4'-trans-linked bicyclic nucleosides with locked S-type furanose conformations is introduced by synthesis of two model derivatives; one was obtained by cyclic ether formation and the other by ring-closing metathesis methodology.
Thomasen
Helena
H
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230, Odense M, Denmark.
Meldgaard
Michael
M
Freitag
Morten
M
Petersen
Michael
M
Wengel
Jesper
J
Nielsen
Poul
P
D003500:Cyclization; D004988:Ethers, Cyclic / Q000737:chemistry; D008968:Molecular Conformation; D009705:Nucleosides / Q000737:chemistry*
D004988:Ethers, Cyclic; D009705:Nucleosides