[Intra-amniotic injection of crystal trichosanthin for induction of labour in second trimester pregnancy].
Labor was induced in a group of 200 women in 2nd trimester of pregnancy by crystal trichosanthia injected into the amniotic cavity.  It was effective and the success rate was 99.5%.  The average abortion inducing interval was 4.69 days porm 1.15 days.  Blood loss was scanty during labor in 90.5% cases, being less than 100 ml.  There was only 1 case suffering laceration of cervix.  The side effects of crystal trichosanthin were dramatically reduced with the simultaneous use of betamethason intramuscularly for 3 successive days.  Side effects were reduced because the drug was concentrated in the cavity and only a little was present in the blood stream and, what's more, the anti-allergic action of betamethason was effective.  Trichosanthin is a kind of plant protein so it will possibly cause allergic reaction, which can induce the production of antibodies that will influence the effect of its reinjection.
Jin
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YC
D000019:Abortifacient Agents; D000028:Abortion, Induced; D005069:Evaluation Studies as Topic; D005193:Family Planning Services; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012098:Reproduction
D000019:Abortifacient Agents
Abortifacient Agents--side effects; Abortion, Drug Induced; Abortion, Induced; Evaluation; Family Planning; Fertility Control, Postconception; Pregnancy; Pregnancy, Second Trimester; Reproduction