Expression of trophinin in the cycling endometrium and its association with infertility.
OBJECTIVE
To observe the expression of trophinin in the cycling endometrium and investigate its relationship with infertility.


METHODS
Trophinin expression in the endometrium was observed in 39 normal cycling women during different menstrual phases and 24 women with infertility during mid-luteal phase by immunohistochemical technique.


RESULTS
Trophinin expression was detected in the luteal-phase endometrium of both normal and infertile women, which peaked in the mid-luteal phase. In comparison with normal women, infertile women with endometriosis or unexplained infertility had significantly weakened trophinin expression in the endometrium in the mid-luteal (P<0.001).


CONCLUSIONS
Trophinin may play an important role in the process of implantation, and abnormal endometrial trophinin expression might be one of the major causes of infertility.
Wang
Hua-Yun
HY
Assisted Reproduction Center, Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Xing
Fu-Qi
FQ
Chen
Shi-Ling
SL
D000328:Adult; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D008183:Luteal Phase / Q000378:metabolism*
D015815:Cell Adhesion Molecules; C093649:TRO protein, human