A novel neuritogenic compound, NGA0187.
A new neuritogenic compound NGA0187 was isolated from the fermentation broth of Acremonium sp. TF-0356. The structure of NGA0187 was determined by means of spectroscopic analysis and X-Ray diffraction. NGA0187 induced significant neurite outgrowth in PC12 cells. However, survival effect of NGA0187 on the primary culture of cerebral cortical neurons was not observed.
Nozawa
Yuriko
Y
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama-shi, Saitama, Japan. yuri.nozawa@po.rd.taisho.co.jp
Sakai
Noriyoshi
N
Matsumoto
Keita
K
Mizoue
Kazutoshi
K
D000363:Agaricales / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D018360:Crystallography, X-Ray; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
C466781:NGA 0187; D009414:Nerve Growth Factors; D014315:Triterpenes