Plasma urotensin II in heart failure.
Urotensin II has vasoconstrictive and negative inotropic effects, suggesting a possible role in circulatory regulation and pathophysiology of heart failure. We developed a sensitive specific RIA and measured plasma urotensin II in patients with heart failure and in controls. Plasma urotensin II was higher in heart failure patients (mean 3.9 pmol/L [SD 1.4]; than in controls (1.9 pmol/L [0.9]; p<0.0001). The role of urotensin II in heart failure, however, has yet to be defined.
Richards
A Mark
AM
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand. mark.richards@cdhb.gov.nz
Nicholls
M Gary
MG
Lainchbury
John G
JG
Fisher
Stephen
S
Yandle
Timothy G
TG
D000368:Aged; D000369:Aged, 80 and over; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011863:Radioimmunoassay; D014579:Urotensins / Q000097:blood*
D014579:Urotensins; C029677:urotensin II