title: Relationship between personality trait and regional cerebral glucose metabolism assessed with positron emission tomography.
abstract: There have been no studies systematically investigating relationships between biogenetic temperament dimensions and patterns of brain glucose metabolism. Nineteen healthy subjects were evaluated regarding the biogenetic temperament using Cloninger's Temperament and Character Inventory (TCI). In addition, [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET) was used to measure regional brain glucose metabolism. Voxel-based correlation analysis was used to test correlations between regional brain glucose metabolism and scores on the TCI. We identified that each temperament dimension, such as Novelty Seeking, Harm Avoidance, and Reward Dependence, was significantly correlated with specific brain regions. The majority of correlations were observed in the areas of paralimbic regions and temporal lobes. The current study provides evidence linking each biogenetic temperament dimension with specific brain areas and provides a promising base for future personality research.
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine and Hospital, 28 Yongun-dong, Chongno-gu, 110-744, Seoul, Republic of Korea.
authors.forename: Tak
authors.initials: T
authors.lastname: Youn
authors.forename: In Kyoon
authors.initials: IK
authors.lastname: Lyoo
authors.forename: Jae-Kim
authors.initials: JK
authors.lastname: Kim
authors.forename: Hae-Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Kyoo-Seob
authors.initials: KS
authors.lastname: Ha
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Kelley Yost
authors.initials: KY
authors.lastname: Abrams
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Lee
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D010551:Personality / Q000502:physiology*; D010555:Personality Inventory; D013694:Temperament / Q000502:physiology*; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18