title: Increased erythropoietin levels in reactive thrombocytosis.
abstract: Erythropoietin, the major humoral regulator of red cell production, was reported to stimulate various levels of megakaryocytopoiesis. We investigated levels of thrombopoietin (TPO) and erythropoietin (EPO) in patients with reactive thrombocytosis (RT) and clonal thrombocytosis (CT). 17 patients with RT and 18 patients with CT and 15 healthy subjects were enrolled into the study. TPO levels were higher in both patient groups than the controls. EPO levels were significantly higher than these in reactive thrombocytosis and in controls (p < 0.05). We suggest that besides TPO, EPO may play an important role in the pathogenesis of RT.
authors.affiliation: Fatih University, Department of Internal Medicine, Ankara, Turkey.
authors.forename: Ozlem Sahin
authors.initials: OS
authors.lastname: Balçik
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oztürk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Dağli
authors.forename: Osman
authors.initials: O
authors.lastname: Kaftan
authors.forename: Ali
authors.initials: A
authors.lastname: Koşar
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Karaaslan
authors.forename: Serafettin
authors.initials: S
authors.lastname: Kirazli
mesh_terms: D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D016022:Case-Control Studies; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013922:Thrombocytosis / Q000097:blood / Q000145:classification / Q000209:etiology*; D034061:Thrombopoiesis; D013926:Thrombopoietin / Q000097:blood
chemical_list: D004921:Erythropoietin; D013926:Thrombopoietin