Benzathine penicillin G and procaine penicillin G in piglets: comparison of intramuscular and subcutaneous injection.
The disposition of penicillin G in piglets is described after intramuscular or subcutaneous injection of depot preparations. The piglets were injected with 33,000 IU/kg or 100,000 IU/kg benzathine + procaine penicillin G intramuscularly or subcutaneously, or 100,000 IU/kg procaine penicillin G intramuscularly or subcutaneously. Intramuscular injection of benzathine + procaine penicillin resulted in higher maximum concentrations in plasma (Cmax) than did subcutaneous injection. The mean residence time (MRT) of penicillin G was longer when the drugs were injected subcutaneously rather than intramuscularly. The plasma concentration versus time profiles of the subcutaneous injections of benzathine + procaine penicillin revealed secondary peaks, possibly reflecting a certain degree of inflammation at the injection site.
Ranheim
B
B
Department of Pharmacology, Microbiology and Food Hygiene, The Norwegian School of Veterinary Science, Oslo. Birgit.Ranheim@veths.no
Ween
H
H
Egeli
A K
AK
Hormazabal
V
V
Yndestad
M
M
Søli
N E
NE
D000818:Animals; D019540:Area Under Curve; D001835:Body Weight; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D004338:Drug Combinations; D005260:Female; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008297:Male; D010401:Penicillin G Benzathine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D010402:Penicillin G Procaine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D010406:Penicillins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D010406:Penicillins; D010402:Penicillin G Procaine; D010401:Penicillin G Benzathine