title: Passive immunization against nicotine attenuates nicotine discrimination.
abstract: Ten rats were trained in a two lever operant chamber to press different levers after a nicotine injection (0.14 mg/kg s.c.) or a saline injection on an FR10 schedule. The rats were then injected i.p. with either 150 mg nicotine-specific IgG or the same amount of control IgG from non-immunized rabbits. On successive days, they were retested with both levers active after a saline injection, a full training dose of nicotine and a half dose of nicotine (0.07 mg/kg s.c.). After saline injection, both groups pressed the saline lever almost exclusively. After each of the nicotine doses, the immunized rats performed a significantly lower percentage of their lever presses on the nicotine lever than did non-immunized rats. The results suggest that passive immunization can interfere with the stimulus properties of nicotine.
authors.affiliation: University of Houston-Clear Lake, TX 77058, USA. malin@cl.uh.edu
authors.forename: David H
authors.initials: DH
authors.lastname: Malin
authors.forename: Candice L
authors.initials: CL
authors.lastname: Alvarado
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Woodhouse
authors.forename: Hilary
authors.initials: H
authors.lastname: Karp
authors.forename: Evelyn
authors.initials: E
authors.lastname: Urdiales
authors.forename: Diana
authors.initials: D
authors.lastname: Lay
authors.forename: Phillip
authors.initials: P
authors.lastname: Appleby
authors.forename: William D
authors.initials: WD
authors.lastname: Moon
authors.forename: Sofiane
authors.initials: S
authors.lastname: Ennifar
authors.forename: Lisa
authors.initials: L
authors.lastname: Basham
authors.forename: Ali
authors.initials: A
authors.lastname: Fattom
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D003213:Conditioning, Psychological; D003463:Cues; D004193:Discrimination Learning; D005260:Female; D007116:Immunization, Passive; D008297:Male; D009538:Nicotine / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012965:Sodium Chloride
chemical_list: D012965:Sodium Chloride; D009538:Nicotine