title: Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.
abstract: A 1X22X41 combinatorial library or 902 compounds of indinavir analogues was synthesized on the solid support to identify a replacement for the aminoindanol moiety at P2'. 2,6-Dimethyl-4-hydroxy phenol was discovered to be a good replacement for aminoindanol.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. subha_raghavan@merck.com
authors.forename: Subharekha
authors.initials: S
authors.lastname: Raghavan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
authors.forename: Ralph T
authors.initials: RT
authors.lastname: Mosley
authors.forename: William A
authors.initials: WA
authors.lastname: Schleif
authors.forename: Lori
authors.initials: L
authors.lastname: Gabryelski
authors.forename: David B
authors.initials: DB
authors.lastname: Olsen
authors.forename: Mark
authors.initials: M
authors.lastname: Stahlhut
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Kuo
authors.forename: Emilio A
authors.initials: EA
authors.lastname: Emini
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Chapman
authors.forename: James R
authors.initials: JR
authors.lastname: Tata
mesh_terms: D020650:Combinatorial Chemistry Techniques; D016333:HIV Protease / Q000737:chemistry / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D019469:Indinavir / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D017320:HIV Protease Inhibitors; D007202:Indicators and Reagents; D019469:Indinavir; D016333:HIV Protease