title: Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome?
abstract: Intensity modulated radiation therapy (IMRT) was given for 32 patients with M0 sinonasal cancer, with a median follow-up of 15 months. Acute toxicity was mucositis grades 1-2 in 28 patients and grade 3 in four patients. No corneal injury was observed, except in one patient where it was present before the start of IMRT. Conjunctivitis and dry eye symptoms were mild (no grade 3-4 toxicity) and no evolution to dry eye syndrome was observed. We conclude that high dose conformality of IMRT results in mild acute toxicity and that IMRT allows avoiding dry eye syndrome by its ability to create concave dose distributions which avoid the main lacrimal glands. Follow-up it too short to evaluate local control, optic nerve or retinal toxicity.
authors.affiliation: Division of Radiotherapy P7, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
authors.forename: Filip
authors.initials: F
authors.lastname: Claus
authors.forename: Tom
authors.initials: T
authors.lastname: Boterberg
authors.forename: Piet
authors.initials: P
authors.lastname: Ost
authors.forename: Wilfried
authors.initials: W
authors.lastname: De Neve
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D018572:Disease-Free Survival; D015352:Dry Eye Syndromes / Q000378:metabolism / Q000517:prevention & control*; D007765:Lacrimal Apparatus / Q000503:physiopathology / Q000528:radiation effects; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000532:radiotherapy*; D010255:Paranasal Sinus Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods*; D015996:Survival Rate; D013666:Tears / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome