title: Difference in prognostic factors between stage IB and II uterine cervical carcinoma patients treated with radical hysterectomy and postoperative radiation therapy.
abstract: OBJECTIVE
  The purpose of the current study was to evaluate the difference in prognostic factors between stage IB and II uterine cervical carcinoma patients treated with postoperative radiation therapy.
  
  
  METHODS
  Between May 1988 and May 1998, a total of 94 patients including 47 patients with stage IB and 47 patients with stage II uterine cervical carcinoma were treated with postoperative radiation therapy at Tokyo Metropolitan Komagome Hospital. All patients were treated with 10 MV X-rays using an anterior-posterior parallel opposed field which covered the whole pelvis. Fractionation was 2 Gy per day, five fractions per week, to a total dose of 50 Gy.
  
  
  RESULTS
  The 5-year overall survival rates of stage IB and II were 89.4% and 79.3%, respectively. In multivariate analysis for all patients, lymph node status, histology, and surgical margin status were recognized as prognostic factors. Limited to stage IB patients, lymph node status was the only independent prognostic factor. However, for stage II patients, tumor histology was also an independent prognostic factor.
  
  
  CONCLUSIONS
  The prognostic factors of stage IB and II were different. Tumor histology was only associated with stage II patients. These findings suggested that tumor histology might have played a different role as tumor stage progressed. However, further studies with large numbers of patients will be required to confirm these results.
authors.affiliation: Department of Radiology, Tokyo Metropolitan Komagome Hospital, Honkomagome, Japan.
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Niibe
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Karasawa
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kaizu
authors.forename: Katsumi
authors.initials: K
authors.lastname: Mizutani
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ueda
authors.forename: Akira
authors.initials: A
authors.lastname: Murakami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*