A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
Moon
Ho-Sang
HS
Department of Chemistry, New York University, New York, NY 10003, USA.
Jacobson
Eric M
EM
Khersonsky
Sonya M
SM
Luzung
Michael R
MR
Walsh
Daniel P
DP
Xiong
Wennan
W
Lee
Jae Wook
JW
Parikh
Puja B
PB
Lam
Jennifer C
JC
Kang
Tae-Wook
TW
Rosania
Gustavo R
GR
Schier
Alexander F
AF
Chang
Young-Tae
YT
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D008870:Microtubules / Q000187:drug effects*; D011687:Purines / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015027:Zebrafish / Q000196:embryology*
D000970:Antineoplastic Agents; D011687:Purines; D014227:Triazines; C407365:myoseverin