title: Rippling muscle disease in childhood.
abstract: Rippling muscle disease is a rare autosomal dominant disorder first described in 1975. Recently, it could be classified as a caveolinopathy; in European families, mutations in the caveolin-3 gene were revealed as causing this disease. Although clinical symptoms were almost all described in adulthood, we are now reporting clinical data of seven children with rippling muscle disease owing to mutations in the caveolin-3 gene. Initial symptoms were frequent falls, inability to walk on heels, tiptoe walking with pain and a warm-up phenomenon, calf hypertrophy, and an elevated serum creatine kinase level. Percussion-/pressure-induced rapid contractions, painful muscle mounding, and rippling could be observed even in early childhood. The diagnosis can be confirmed by molecular genetic analysis. Muscle biopsy must be considered in patients without muscle weakness or mechanical hyperirritability to differentiate between rippling muscle disease and limb-girdle muscular dystrophy 1C.
authors.affiliation: Department of Pediatrics, Ruhr-University Bochum, Germany. Ulrike.Schara@t-online.de
authors.forename: Ulrike
authors.initials: U
authors.lastname: Schara
authors.forename: Matthias
authors.initials: M
authors.lastname: Vorgerd
authors.forename: Nikola
authors.initials: N
authors.lastname: Popovic
authors.forename: Benedikt G H
authors.initials: BG
authors.lastname: Schoser
authors.forename: Kenneth
authors.initials: K
authors.lastname: Ricker
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Mortier
mesh_terms: D000293:Adolescent; D015153:Blotting, Western; D051244:Caveolin 3; D022461:Caveolins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008856:Microscopy, Fluorescence; D018482:Muscle, Skeletal / Q000473:pathology; D009135:Muscular Diseases / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D010812:Physical Stimulation
chemical_list: D051244:Caveolin 3; D022461:Caveolins; D003402:Creatine Kinase