Tests of the pharmacodynamics and toxicity of Duliang capsule.
OBJECTIVE
To study the analgesic efficacy, toxicity and impact of Duliang capsule (DLC) and Duliang pill (DLP), different dosage forms of a patent Chinese herbal medicine, on the hemodynamics in mice and rats.


METHODS
In hotplate and writhing tests in mice, the effects of both drugs on the latency of paw-licking response and the writhing number of times were observed. The changes of blood viscosity in rat models of blood stasis were measured with Viscometer-R80, and acute and chronic toxicity of DLC observed.


RESULTS
DLP at the dose of 5 g/kg.b.w. and DLC at 10, 5 or 3 g/kg.b.w. significantly prolonged the latency of paw-licking response and reduced writhing times. The analgesic effects of DLC and DLP occurred 0.5 and 1 h respectively after the administration, and they could both lower the viscosity of the whole blood and hematocrit level in the blood-stasis rat models. Toxicity of the drug was not observed in acute or chronic toxicity tests.


CONCLUSIONS
Both DLC and DLP possess strong analgesic effect and can lower blood viscosity and hematocrit, but DLC takes effect sooner than DLP as analgesics and can be effectively and safely applied clinically.
Deng
Hong-Zhu
HZ
Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China.
Chen
Yu-Yao
YY
Chen
Jiang-Hua
JH
Xiao
Wei
W
D000818:Animals; D002214:Capsules / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal; D005260:Female; D006439:Hemodynamics; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D013607:Tablets / Q000009:adverse effects*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D013607:Tablets