[Influence of alum on intestinal flora in mice].
OBJECTIVE
To observe the influence of alum on the intestinal microecological balance in normal microorganisms.


METHODS
The mice were administered orally with alum of a small dosage(0.25/kg) and a large dosage(1 g/kg) for half a month, two months and three months, and a micro flora analysis of the mice was carried out at intervals of the above mentioned administrations.


RESULTS
The intestinal flora in the animals administered with alum was imbalanced. The counts of bifidobacteria and lactobacilli closely related to human physiological activities were decreased. The counts of pathogenic E. Coli significantly increased; and the longer the animals were treated with alum, the stronger the microecological balance was influenced.


CONCLUSIONS
Alum could induce imbalance of the normal intestinal flora in mice.
Yan
M
M
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700.
Song
H
H
Zhang
L
L
Wang
Y
Y
Wu
Y
Y
Zhou
Z
Z
D000534:Alum Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development*; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000254:growth & development*; D005260:Female; D007422:Intestines / Q000382:microbiology*; D007778:Lactobacillus / Q000254:growth & development; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D011897:Random Allocation; D013997:Time Factors
D000534:Alum Compounds; D008419:Materia Medica; C041524:aluminum sulfate