[Evolution of the genetic code and earliest proteins. Reconstruction from the current sequences].
One would expect that present-day protein sequences have changed many times during their evolution, at every point, so that there is no chance to recognize in the sequences any traces of their ancient organization. It turns out to be not true. Massive analysis of complete genomes of bacteria allows one to derive, according to very specific predictions, distinct features of very early sequences and to outline the history of evolution protein. Modern proteins appear to have evolved from short peptides of mixed sequences of two alphabet types. They were then closed to sequences of optimal size from which modern folds/domains and multidomain proteins were formed. The reconstruction of amino acid and codon chronology is described. A specific idea on the nature and evolutionary significance of gene splicing is suggested. The gene splicing, while obeying the rules of basic structural organization of proteins, offers accessibility to regions of sequence space that could not be reached by mutational changes typical for prokaryotes.
Trifonov
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Department of Structural Biology, Weizmann Institute of Sience, Rehovot, 76100 Israel.
D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D005815:Genetic Code; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*
D011506:Proteins