Synthesis of poly(maleimide-co-2-ethylacrylic acid) and its properties of suppressing metastasis and growth of carcinoma.
A series of copolymers is prepared using maleimide and 2-ethylacrylic acid as comonomer. This kind of copolymer shows low toxicity (LD50: 601-798 mg/kg) and significant curative effect on Lewis lung carcinoma and S180.
Zhu
Zhongliang
Z
Department of Macromolecular Science, The Key Laboratory of Molecular Engineering, Education Ministry of China, Fudan University, Shanghai, People's Republic of China.
Shi
Lianjun
L
Huang
Junlian
J
D000179:Acrylates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D051379:Mice; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000473:pathology; D009368:Neoplasm Transplantation; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship
D000179:Acrylates; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011108:Polymers; C471905:poly(maleimide-co-2-ethylacrylic acid)