title: Benzodiazepine inhibitors of the MMPs and TACE.
abstract: A series of benzodiazepine inhibitors of the MMPs and TACE has been developed. These compounds display an interesting selectivity profile and should be useful tools for exploring the biological relevance of such selectivity.
authors.affiliation: Wyeth Research, 401N. Middletown Road, Pearl River, NY 10965, USA. nelson@wyeth.com
authors.forename: Frances C
authors.initials: FC
authors.lastname: Nelson
authors.forename: Efren
authors.initials: E
authors.lastname: Delos Santos
authors.forename: Jeremy I
authors.initials: JI
authors.lastname: Levin
authors.forename: James M
authors.initials: JM
authors.lastname: Chen
authors.forename: Jerauld S
authors.initials: JS
authors.lastname: Skotnicki
authors.forename: John F
authors.initials: JF
authors.lastname: DiJoseph
authors.forename: Michele A
authors.initials: MA
authors.lastname: Sharr
authors.forename: Amy
authors.initials: A
authors.lastname: Sung
authors.forename: Loran M
authors.initials: LM
authors.lastname: Killar
authors.forename: Rebecca
authors.initials: R
authors.lastname: Cowling
authors.forename: Guixian
authors.initials: G
authors.lastname: Jin
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Roth
authors.forename: J Donald
authors.initials: JD
authors.lastname: Albright
mesh_terms: D051722:ADAM Proteins; D000072198:ADAM17 Protein; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000494:pharmacology*; D002356:Cartilage / Q000187:drug effects / Q000201:enzymology; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D011719:Pyrazines; D013329:Structure-Activity Relationship; D013449:Sulfonamides
chemical_list: C097658:CGS 27023A; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D011719:Pyrazines; D013449:Sulfonamides; D001569:Benzodiazepines; D051722:ADAM Proteins; D008666:Metalloendopeptidases; D000072198:ADAM17 Protein