title: Who discovered the Frank-Starling mechanism?
abstract: In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.
authors.affiliation: Carl-Ludwig-Institute of Physiology, University of Leipzig, D-04103 Leipzig, Germany.
authors.forename: Heinz-Gerd
authors.initials: HG
authors.lastname: Zimmer
mesh_terms: D004739:England; D005858:Germany; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics; D049672:History, 19th Century; D049673:History, 20th Century; D009200:Myocardial Contraction / Q000502:physiology; D010827:Physiology / Q000266:history*