Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae).
Anti-inflammatory activity of an ethanolic extract from Bouchea fluminensis leaves was demonstrated. From de ethanolic extract, the active compound was isolated and characterized as the iridoid lamiide. The activity of lamiide on rat-brain phospholipid peroxidation showed a powerful effect (IC(50)=0.92+/-0.01 mM) and an anti-inflammatory activity in carrageenin-induced paw edema test (ED(50)=62.3+/-7 mg/kg weight).
Delaporte
Rosemeres Horwat
RH
Instituto Superior de Ciências Farmacêuticas e Bioquímica, Universidade Paranaense, Umuarama, Paraná, Brazil. delaporte@uol.com.br
Sánchez
Gregorio Martínez
GM
Cuellar
Armando Cuellar
AC
Giuliani
Attilia
A
Palazzo de Mello
João Carlos
JC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D029648:Verbenaceae / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D039823:Iridoids; D010936:Plant Extracts