No association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia.
Genetic components are involved in the aetiology of schizophrenia. Activating Protein 2 (AP-2) transcription factors are essential for neural gene expression and neural development. Transcription factor AP-2beta has also been connected with monoaminergic genes and monoamine levels in various brain regions. Thus, the AP-2beta gene is a suitable candidate taking both the neurodevelopmental and dopamine hypotheses of schizophrenia into account. We investigated 135 schizophrenic patients and 382 control subjects with regard to an intronic AP-2beta variant without evidence of any association. We conclude that the investigated AP-2beta variant is not of major importance to schizophrenia in the investigated Swedish population.
Jönsson
Erik G
EG
Department of Clinical Neuroscience, HUBIN project, Psychiatry Section, Karolinska Institute and Hospital, SE-171 76 Stockholm, Sweden. erikj@ks.se
Damberg
Mattias
M
Forslund
Kaj
K
Mattila-Evenden
Marja
M
Rylander
Gunnar
G
Asberg
Marie
M
Oreland
Lars
L
Sedvall
Göran C
GC
D000328:Adult; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D013548:Sweden; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*; D044465:White People
D004268:DNA-Binding Proteins; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; D014157:Transcription Factors