Muscle oxygenation and ATP turnover when blood flow is impaired by vascular disease.
31P magnetic resonance spectroscopy (31P MRS) and near-infrared spectroscopy (NIRS) are combined to study interactions between oxidative ATP synthesis rate, perturbation of the creatine kinase equilibrium, and cellular oxygenation state in calf muscle of normal subjects and patients with muscle perfusion impaired by peripheral vascular disease.
Kemp
G J
GJ
Department of Musculoskeletal Science, University of Liverpool, UK.
Roberts
N
N
Bimson
W E
WE
Bakran
A
A
Frostick
S P
SP
D000255:Adenosine Triphosphate / Q000378:metabolism*; D003402:Creatine Kinase / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008931:Mitochondria, Muscle / Q000378:metabolism; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010100:Oxygen / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism*
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D010100:Oxygen