title: [Experimental study on antiendotoxin effect of extracts from Artemisia annua L].
abstract: OBJECTIVE
  To explore the antiendotoxin effect of extracts from Artemisia annua (AA) and qinghaosu (QHS).
  
  
  METHODS
  LPO and SOD in chondriosome, ACP in lysosomes, tumor nicrosis factor-alpha(TNF-alpha) and endotoxin in plasma, and P450 concentration in hepatic microsome of rats were determined. Mortality of endotoxemic mice and histomorphology were observed.
  
  
  RESULTS
  LPO, ACP, endotoxin, TNF-alpha and P450 content were decreased with AA and QHS. SOD activity was increased with AA and QHS. At the same time, mortality was decreased. Histomorphology of lysosomes and chondriosome of rats were protected from endotoxin.
  
  
  CONCLUSIONS
  AA and QHS possess an antiendotoxin effect.
authors.affiliation: Hospital 303 of PLA, Nanning 530021.
authors.forename: Y
authors.initials: Y
authors.lastname: Tan
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: Q
authors.initials: Q
authors.lastname: Lin
authors.forename: G
authors.initials: G
authors.lastname: Xie
authors.forename: P
authors.initials: P
authors.lastname: Yang
authors.forename: X
authors.initials: X
authors.lastname: Yin
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D037621:Artemisinins / Q000302:isolation & purification / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors* / Q000097:blood; D005260:Female; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D012717:Sesquiterpenes; D003577:Cytochrome P-450 Enzyme System; C031327:artemisinin; D013482:Superoxide Dismutase