title: Quantifying the harmful effect of psoriasis on health-related quality of life.
abstract: BACKGROUND
  Psoriasis affects 7 million people in the United States, causing substantial cost, social stigma, and disability.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the health effects of skin disease by comparing psoriasis to other primary medical disorders using 3 different scales of health-related quality of life.
  
  
  METHODS
  A self-administered questionnaire consisting of 3 health-related quality of life measures was given sequentially to 35 eligible patients with psoriasis presenting to the Dermatology Branch of the National Cancer Institute (NCI) for an investigational therapeutic protocol.
  
  
  RESULTS
  All patients (100%) agreed to participate. The median Psoriasis Area and Severity Index (PASI) score was 13.0. Overall, 82.9% at least often felt the need to hide their psoriasis, and 74.3% claimed their self-confidence was at least often affected by their psoriasis. The median EQ-5D health state utility score was 13.0% less than healthy individuals (P <.001). On the SF-36, the mean general health score was 13.2% less (P =.005) and the median social functioning score 18.7% less (P =.005) than that of patients with no chronic conditions.
  
  
  CONCLUSIONS
  Individuals with psoriasis are significantly affected in their health state utility, perception of general health, and social functioning when compared with individuals without chronic disease and those with certain primary medical conditions.
authors.affiliation: Department of Clinical Bioethics, Warren G. Magnuson Clinical Center, the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Stefan C
authors.initials: SC
authors.lastname: Weiss
authors.forename: Alexa B
authors.initials: AB
authors.lastname: Kimball
authors.forename: David J
authors.initials: DJ
authors.lastname: Liewehr
authors.forename: Andrew
authors.initials: A
authors.lastname: Blauvelt
authors.forename: Maria L
authors.initials: ML
authors.lastname: Turner
authors.forename: Ezekiel J
authors.initials: EJ
authors.lastname: Emanuel
mesh_terms: D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000523:psychology; D011788:Quality of Life