title: Panhypopituitarism in a child with common variable immunodeficiency.
abstract: BACKGROUND
  Common variable immunodeficiency (CVID) represents a group of heterogeneous, still undifferentiated, syndromes that are all characterized by defective antibody formation. It is often associated with autoimmune disease.
  
  
  METHODS
  An African-American girl was diagnosed with CVID at age 3 years. She was seen during an adrenal crisis precipitated by pneumonia at the age of 8 years and 10 months. The diagnosis of panhypopituitarism was established soon after.
  
  
  RESULTS
  Panhypopituitarism in this patient was believed to be the result of the autoimmune process known as lymphocytic hypophysitis. This hypothesis was suggested by the results of magnetic resonance imaging.
  
  
  CONCLUSIONS
  Awareness of the possibility of this process in children or adults with CVID may lead to earlier diagnosis of panhypopituitarism. These patients also have failure to thrive, and earlier diagnosis may avoid a life-threatening event.
authors.affiliation: Division of Allergy, Immunology, and Rheumatology, Children's Hospital of Michigan, Detroit 48201, USA.
authors.forename: Jihad S
authors.initials: JS
authors.lastname: Younes
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Secord
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology*; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis / Q000209:etiology*; D008214:Lymphocytes; D008279:Magnetic Resonance Imaging