title: [Entacapone for treatment of motor fluctuations in idiopathic Parkinson syndrome].
abstract: The treatment of idiopathic Parkinson's disease becomes rather difficult if levodopa-induced late complications such as motor fluctuations or dyskinesias occur. This prospective and open study shows that an add-on therapy with entacapone can significantly lower wearing-off and end-of-dose akinesia. This treatment is well tolerated and easy to perform.
authors.affiliation: Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl-Gustav-Carus, Dresden. Ulrike.Sommer@neuro.med.tu-dresden.de
authors.forename: U
authors.initials: U
authors.lastname: Sommer
authors.forename: A
authors.initials: A
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Herting
authors.forename: K
authors.initials: K
authors.lastname: Cormann
authors.forename: F
authors.initials: F
authors.lastname: Kohlert
authors.forename: H
authors.initials: H
authors.lastname: Reichmann
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002396:Catechols / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects*; D009460:Neurologic Examination / Q000187:drug effects*; D009570:Nitriles; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D000978:Antiparkinson Agents; D002396:Catechols; D009570:Nitriles; C071192:entacapone