[Entacapone for treatment of motor fluctuations in idiopathic Parkinson syndrome].
The treatment of idiopathic Parkinson's disease becomes rather difficult if levodopa-induced late complications such as motor fluctuations or dyskinesias occur. This prospective and open study shows that an add-on therapy with entacapone can significantly lower wearing-off and end-of-dose akinesia. This treatment is well tolerated and easy to perform.
Sommer
U
U
Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl-Gustav-Carus, Dresden. Ulrike.Sommer@neuro.med.tu-dresden.de
Müller
A
A
Herting
B
B
Cormann
K
K
Kohlert
F
F
Reichmann
H
H
D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002396:Catechols / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects*; D009460:Neurologic Examination / Q000187:drug effects*; D009570:Nitriles; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies
D000978:Antiparkinson Agents; D002396:Catechols; D009570:Nitriles; C071192:entacapone