Influence of portal vein and liver artery ligation on the toxicokinetics of soman in rabbits.
The portal vein, liver artery ligation treatment and the portal vein ligation treatment could increase the concentration of P(-) soman in rabbit blood 3.6-19.3 times as compared with soman control group at each time points after soman injection (43.2 microgkg(-1), i.v.). Toxicokinetics parameters showed that portal vein, liver artery ligation treatment and portal vein ligation treatment could reduce the clearance (CL) and distribution volume (V(d)). Meanwhile, they could significantly increase the AUC of soman in rabbits from 2.08+/-0.154 to 18.2+/-2.96 and 22.9+/-3.73 mg s l(-1), respectively. All these data showed that the liver and intestine play a very important role on elimination the free soman in rabbit's blood at high dosing of soman.
Li
Jin-Tong
JT
Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, 100850, Beijing, People's Republic of China. leejohnton@yahoo.com
Ruan
Jin-Xiu
JX
Zhang
Zhen-Qing
ZQ
Yuan
Shu-Lan
SL
Song
Zheng-Yan
ZY
Han
Dong
D
D000818:Animals; D019540:Area Under Curve; D002800:Cholinesterase Inhibitors / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D006499:Hepatic Artery / Q000601:surgery; D008026:Ligation / Q000662:veterinary; D008099:Liver / Q000098:blood supply*; D011169:Portal Vein / Q000601:surgery; D011817:Rabbits / Q000378:metabolism* / Q000601:surgery; D012999:Soman / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D013237:Stereoisomerism
D002800:Cholinesterase Inhibitors; D012999:Soman