title: Bone resorption versus estrogen loss following oophorectomy and menopause.
abstract: OBJECTIVE
  To investigate if menopause and oophorectomy may represent different risk factors for bone resorption/loss.
  
  
  METHODS
  The urinary levels of pyridinoline (Pyr) and deoxypyridinoline (D-pyr), the serum levels of type I carboxy-terminal pyridinoline cross-linked telopeptide (ICTP), and lumbar bone mineral density (BMD), were compared in 80 Japanese women after menopause or oophorectomy. These women were divided into four groups of 20 women each as follows: early postmenopausal stage (early physiologic menopause < 3 years before study entry); late postmenopausal stage (physiologic menopause > or = 3 years before study entry); early postoophorectomy stage (oophorectomy < or = 03 years before study entry); or late oophorectomy stage (oophorectomy > 3 years before study entry).
  
  
  RESULTS
  Lumbar BMD was significantly lower in the late groups compared to their respective early groups and was lowest in the late postoophorectomy group. The ratio of D-pyr/creatinine (Cr) was not significantly different among the four groups. The ratio of Pyr/Cr was significantly higher in the early postoophorectomy subjects compared with either late group. The serum level of ICTP was significantly higher in the early postoophorectomy group compared to all other groups.
  
  
  CONCLUSIONS
  These findings suggest that serum ICTP may be useful in detecting changes in bone resorption after oophorectomy and that women are at greater risk for bone resorption after oophorectomy than after physiologic menopause, although this difference appears to diminish with time.
authors.affiliation: Department of Obstetrics and Gynecology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. ohtah@obgy.twmu.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohta
authors.forename: Kazuya
authors.initials: K
authors.lastname: Makita
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Komukai
authors.forename: Shiro
authors.initials: S
authors.lastname: Nozawa
mesh_terms: D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000378:metabolism*; D002118:Calcium / Q000652:urine; D024042:Collagen Type I; D003404:Creatinine / Q000652:urine; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000378:metabolism*; D010052:Ovariectomy; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides; D011347:Procollagen / Q000097:blood
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; D004958:Estradiol; C015484:pyridinoline; C036020:deoxypyridinoline; D003404:Creatinine; D006909:Hydroxyproline; D002118:Calcium