title: Agrin in the developing CNS: new roles for a synapse organizer.
abstract: The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer's disease is accumulating.
authors.affiliation: Institute for Physiological Chemistry and Pathobiochemistry, University of Mainz, D-55099 Mainz, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Kröger
authors.forename: Jörn E
authors.initials: JE
authors.lastname: Schröder
mesh_terms: D018171:Agrin / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D002490:Central Nervous System / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D013569:Synapses / Q000502:physiology*
chemical_list: D018171:Agrin