title: Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.
abstract: Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.
authors.affiliation: UPRES EA 1085, Biomolécules et cibles cellulaires tumorales, Faculté de Pharmacie, 2 rue du Docteur Marcland, Limoges, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Pouget
authors.forename: Catherine
authors.initials: C
authors.lastname: Fagnere
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Basly
authors.forename: Gérard
authors.initials: G
authors.lastname: Habrioux
authors.forename: Albert Jośe
authors.initials: AJ
authors.lastname: Chulia
mesh_terms: D001141:Aromatase / Q000737:chemistry; D047072:Aromatase Inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011522:Protons; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D005419:Flavonoids; D007093:Imidazoles; D011522:Protons; D001141:Aromatase