title: Longitudinal evaluation of leukoaraiosis with whole brain ADC histograms.
abstract: FLAIR and diffusion-weighted MRI were obtained twice (mean interval 20 +/- 4 months) in 10 patients with leukoaraiosis. At follow-up, visual extension of leukoaraiosis was unchanged, whereas the median of whole brain apparent diffusion coefficient (WB-ADC) histogram was increased (p= 0.008) and brain volume index (BVI) was decreased (p = 0.006). WB-ADC histogram and BVI are sensitive to leukoaraiosis and might be considered for monitoring progression of the disease.
authors.affiliation: Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, USA. m.mascalchi@dfc.unifi.it
authors.forename: M
authors.initials: M
authors.lastname: Mascalchi
authors.forename: M
authors.initials: M
authors.lastname: Moretti
authors.forename: R
authors.initials: R
authors.lastname: Della Nave
authors.forename: F
authors.initials: F
authors.lastname: Lolli
authors.forename: C
authors.initials: C
authors.lastname: Tessa
authors.forename: G
authors.initials: G
authors.lastname: Carlucci
authors.forename: L
authors.initials: L
authors.lastname: Bartolini
authors.forename: G
authors.initials: G
authors.lastname: Pracucci
authors.forename: L
authors.initials: L
authors.lastname: Pantoni
authors.forename: M
authors.initials: M
authors.lastname: Filippi
authors.forename: D
authors.initials: D
authors.lastname: Inzitari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000473:pathology*; D005260:Female; D006801:Humans; D007960:Leukocyte Disorders / Q000473:pathology; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric