Anti-inflammatory effects of the macrolides.
Since their introduction into clinical practice, the macrolides have played an important role in the treatment of both upper and lower respiratory tract disease. In addition to their antibacterial effects, increased evidence is mounting to suggest that the macrolides possess other clinically relevant properties, such as anti-inflammatory and immunomodulatory activities. Several in vitro and clinical trials have been published supporting this hypothesis. This article reviews some of the evidence.
Davidson
Ross
R
Department of Pathology and Laboratory Medicine, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia.
Péloquin
Louis
L
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017291:Clarithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009079:Mucociliary Clearance / Q000187:drug effects*; D012852:Sinusitis / Q000188:drug therapy
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D017291:Clarithromycin