title: Treatment of primary limited cutaneous extramammary Paget's disease with topical imiquimod monotherapy: two case reports.
abstract: We present two cases of primary limited cutaneous perineal and genital extramammary Paget's disease (EMPD) that were successfully treated with imiquimod 5% cream. Clinical and histologic cure was confirmed after 7.5 to 12 weeks of monotherapy. Treatment-associated morbidity is minimal compared with more invasive therapies, and self-application by the patient improves convenience and appeal. Imiquimod may offer a minimally invasive and promising therapeutic option for the treatment of limited cutaneous EMPD. The diagnosis and management of EMPD and the current literature regarding imiquimod therapy are reviewed.
authors.affiliation: Division of Dermatology and Cutaneous Surgery, University of Florida College of Medicine, Gainesville, 32610-0277, USA.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Zampogna
authors.forename: Franklin P
authors.initials: FP
authors.lastname: Flowers
authors.forename: William I
authors.initials: WI
authors.lastname: Roth
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: Hassenein
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000627:therapeutic use; D000287:Administration, Topical; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D000077271:Imiquimod; D007369:Interferon Inducers / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000188:drug therapy*; D010502:Perineum; D012611:Scrotum; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D007369:Interferon Inducers; D000077271:Imiquimod