title: Protein degradation with photoactivated enediyne-amino acid conjugates.
abstract: A series of photoactivated enediynes was prepared, and successfully employed for the selective degradation of target proteins.
authors.affiliation: Department of Chemistry, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Plourde
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Shafey
authors.forename: Farid S
authors.initials: FS
authors.lastname: Fouad
authors.forename: Ajay S
authors.initials: AS
authors.lastname: Purohit
authors.forename: Graham B
authors.initials: GB
authors.lastname: Jones
mesh_terms: D004249:DNA Damage / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D006657:Histones / Q000737:chemistry / Q000187:drug effects; D007202:Indicators and Reagents; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010777:Photochemistry; D011506:Proteins / Q000737:chemistry / Q000187:drug effects*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000187:drug effects
chemical_list: D006657:Histones; D007202:Indicators and Reagents; D009844:Oligosaccharides; D011506:Proteins; D011743:Pyrimidines; D012710:Serum Albumin, Bovine