title: HIV and STDs: how are they linked?
abstract: I write in response to Dr. Gina Dallabeta's article with this title (HIV and STDs: How Are They Linked?). Prospective studies in sub-Saharan Africa have established the following: 1. Seropositive commercial sex workers have a higher prevalence of genital ulcer disease (GUD) and positive serology for syphilis. 2. Seropositive men with chancroid more frequently have a history of prior GUD. 3. Seronegative men with a history of recent contact with a commercial sex worker are more likely to seroconvert if they have GUD than urethritis. GUD increases the infectiousness of HIV. Similarly, there is increased susceptibility to the virus in cases of genital chlamydial infection and Trichomonas vaginalis. The mechanisms are basically two--mechanical and biological. Mechanically, the raw area resulting from the STD provides a portal of entry for the virus. Biologically, activated lymphocytes and macrophages enhance HIV shedding and increase the susceptibility of the individual to HIV.
authors.forename: F
authors.initials: F
authors.lastname: Muwanga
mesh_terms: D000349:Africa; D001519:Behavior; D001695:Biology; D003906:Developing Countries; D004194:Disease; D015658:HIV Infections; D007239:Infections; D012307:Risk Factors; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases; D014777:Virus Diseases
keywords: Africa; Behavior; Biology; Developing Countries; Diseases; Hiv Infections; Infections; Prostitutes; Reproductive Tract Infections; Risk Factors; Sex Behavior; Sexually Transmitted Diseases; Viral Diseases