[Piper methysticum (kava) under discussion: observations on quality, effectiveness and safety].
Worldwide the application for a drug registration follows three basic principles: the proof of quality, efficacy and safety. In the following the applicability of these three principles on extracts from roots of the medicinal plant Kava (Piper methysticum) will be examined in the light of the current discussion of possible hepatic side effects ratio.
Schmidt
M
M
Institut für Pharmazeutische Biologie und Phytochemie, Universität Münster, Deutschland. schmidt@redinomedica.de
Nahrstedt
A
A
Lüpke
N P
NP
D016907:Adverse Drug Reaction Reporting Systems; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002986:Clinical Trials as Topic; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D011786:Quality Control; D016896:Treatment Outcome
D014151:Anti-Anxiety Agents; D010936:Plant Extracts