Asymmetric functional divergence of duplicate genes in yeast.
Most duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Here, I present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if asymmetrically diverging duplicate gene pairs show increased robustness to deleterious mutations.
Wagner
Andreas
A
Department of Biology, University of New Mexico, Albuquerque, USA. wagnera@unm.edu
D004777:Environment; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000235:genetics; D020440:Gene Duplication; D015870:Gene Expression; D005800:Genes, Fungal; D016681:Genome, Fungal; D008957:Models, Genetic; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D020798:Two-Hybrid System Techniques
D005656:Fungal Proteins