Synthesis of the bicyclic dienone core of the antitumor agent ottelione B.
The intramolecular Diels-Alder adduct 12 was converted via dimesylate 20 into dienone 7, which represents the unusual, and apparently quite stable, core of the antitumor agent ottelione B (1).
Clive
Derrick L J
DL
Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca
Fletcher
Stephen P
SP
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry*; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D003512:Cyclohexanones; C468747:ottelione B