De-acclimatization process of rats acclimatized to high altitude hypoxia.
The de-acclimatization process in rats acclimatized to high altitude hypoxia was analyzed according to the changes in the activities of hepatic enzymes. The activities of tryptophan 2,3-dioxygenase and tyrosine aminotransferase in the liver of non-acclimatized rats were increased, whereas those of acclimatized rats were decreased after exposure to a simulated altitude of 8,000 m. When the acclimatized rats were kept under normoxic conditions for 8 days and over, the suppression of enzyme induction was nullified, and both enzymes were induced by exposure to the simulated 8,000 m altitude. De-acclimatization of rats acclimatized to hypoxia can be completed in 8-11 days.
Yamamoto
C
C
Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Mori
S
S
Murata
Y
Y
Seo
H
H
Nakatsuka
M
M
Yoshino
M
M
D000064:Acclimatization / Q000502:physiology*; D000531:Altitude; D000818:Animals; D001273:Atmosphere Exposure Chambers; D000860:Hypoxia / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014366:Tryptophan Oxygenase / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000378:metabolism
D014366:Tryptophan Oxygenase; D014444:Tyrosine Transaminase