title: Comparative study of the efficacy of topical corticosteroid: five locally made and one brand name creams.
abstract: The aim of this study was to evaluate the efficacy of 5 locally made clobetasol propionate creams compared with a brand name product. The study was divided into 3 parts 1) pharmacological study, 2) vasoconstriction test, and 3) double blind clinical trial. The results showed that the pharmacological properties of the locally made products were not different from the brand name product. Product C and D could diffuse through cellulose acetate membrane 3 fold more than the brand name product. Product D and E caused less vasoconstriction than the brand name product. This double blind study showed that all locally made products could improve psoriasis to the same extent as the brand name product, but there was more recurrence of psoriasis while using all the locally made products. It was concluded that locally made products were as effective as the brand name product in the treatment of psoriasis evaluated over a 2 week peroid, but more recurrence was observed with locally made products.
authors.affiliation: Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Siripen
authors.initials: S
authors.lastname: Puavilai
authors.forename: Panwipa
authors.initials: P
authors.lastname: Krisadaphong
authors.forename: Vichit
authors.initials: V
authors.lastname: Leenutaphong
authors.forename: Pravit
authors.initials: P
authors.lastname: Asawanonda
authors.forename: Rutsanee
authors.initials: R
authors.lastname: Akaraphan
authors.forename: Tanusin
authors.initials: T
authors.lastname: Ploysangham
authors.forename: Suwanna
authors.initials: S
authors.lastname: Ruangkarnchanasetr
authors.forename: Nopadon
authors.initials: N
authors.lastname: Noppakun
authors.forename: Somyot
authors.initials: S
authors.lastname: Charuwichitratana
authors.forename: Kanokvalai
authors.initials: K
authors.lastname: Kulthanan
authors.forename: Porntip
authors.initials: P
authors.lastname: Huiprasert
authors.forename: Poohglin
authors.initials: P
authors.lastname: Tresukosol
authors.forename: Suwirakorn
authors.initials: S
authors.lastname: Ophaswongse
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002990:Clobetasol / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016568:Drugs, Generic / Q000008:administration & dosage* / Q000627:therapeutic use*; D005938:Glucocorticoids; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D016568:Drugs, Generic; D005938:Glucocorticoids; D002990:Clobetasol