title: Virtual mitochondria: metabolic modelling and control.
abstract: Inside the eukaryotic cell, mitochondria are internal organelles of prokaryotic origin, responsible for energy supply in the cell. The control of the mitochondrial ATP production is a complex problem with different patterns according to different tissues and organs. Our aim is to continue to develop the modelling of oxidative phosphorylation in different tissues, to model other parts of mitochondrial metabolism and to include this virtual mitochondria in a virtual cell. In constructing the complete metabolic map of mitochondria, we will take advantage of the sequenced genomes of eukaryotic organism (10-15% of the yeast genome concerns mitochondria).
authors.affiliation: Inserm EMI 9929, Université de Bordeaux 2, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Aimar-Beurton
authors.forename: Bernard
authors.initials: B
authors.lastname: Korzeniewski
authors.forename: Thierry
authors.initials: T
authors.lastname: Letellier
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ludinard
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Mazat
authors.forename: Christine
authors.initials: C
authors.lastname: Nazaret
mesh_terms: D000818:Animals; D016678:Genome; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D010085:Oxidative Phosphorylation; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D010940:Plant Proteins