Genetic structure of Anopheles gambiae (Diptera: Culicidae) in São Tomé and Príncipe (West Africa): implications for malaria control.
The impact of a vector eradication programme, conducted in the 1980s, on Anopheles gambiae populations from the islands of São Tomé and Príncipe, was evaluated by microsatellite DNA analysis. Significant genetic differentiation was observed within and between the two islands and between the islands and a population from Gabon, suggesting a degree of isolation between them. Large estimates of long-term N(e) suggested that the control programme did not affect the effective population size of the vector. Heterozygosity tests were also not consistent with a recent bottleneck.
Pinto
J
J
Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa. Rua da Junqueira 96 1349-008 Lisbon, Portugal.
Donnelly
M J
MJ
Sousa
C A
CA
Gil
V
V
Ferreira
C
C
Elissa
N
N
do Rosário
V E
VE
Charlwood
J D
JD
D000354:Africa, Western; D000818:Animals; D000852:Anopheles / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D006579:Heterozygote; D007303:Insect Vectors / Q000235:genetics; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D018895:Microsatellite Repeats