title: Minute findings by magnifying colonoscopy are useful for the evaluation of ulcerative colitis.
abstract: BACKGROUND
  Colonoscopy has an important role in the diagnosis of ulcerative colitis. However, colonoscopic findings are inadequate for the prediction of relapse without histologic examination. In this study, the role of magnifying colonoscopy in ulcerative colitis was evaluated.
  
  
  METHODS
  One hundred sixteen magnifying colonoscopy observations were made in 61 patients with ulcerative colitis between January 1994 and October 1998. A simple classification of magnifying colonoscopic findings into 5 categories was devised as follows: regularly arranged crypt openings, villous-like, minute defects of epithelium, small yellowish spots, and coral reef-like appearance. The colonoscopic findings by classification were compared with histopathologic findings, and the usefulness of the classification for predicting relapse was prospectively analyzed in 18 patients.
  
  
  RESULTS
  Compared with grade as determined by conventional colonoscopy, there was a better correlation between the classification of findings by magnifying colonoscopy and histopathologic findings (r(2) = 0.665, 0.807, respectively). Of 18 patients studied prospectively, 7 of 9 with minute defects of epithelium relapsed within 6 months, and the cumulative nonrelapsing rate was significantly lower in patients with minute defects of epithelium compared with those without minute defects of epithelium (p = 0.0059). Moreover, minute defects of epithelium was found to be a significant independent predictive factor for relapse (multivariate analysis, Cox proportional hazards model; p = 0.0203).
  
  
  CONCLUSIONS
  Our proposed classification of magnifying colonoscopic findings in patients with ulcerative colitis is useful for the evaluation of disease activity and for the prediction of periods of remission.
authors.affiliation: Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan.
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Fujiya
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Masafumi
authors.initials: M
authors.lastname: Nomura
authors.forename: Atsuo
authors.initials: A
authors.lastname: Maemoto
authors.forename: Kaori
authors.initials: K
authors.lastname: Fujiya
authors.forename: Jiro
authors.initials: J
authors.lastname: Watari
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ashida
authors.forename: Tokiyoshi
authors.initials: T
authors.lastname: Ayabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Obara
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kohgo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003093:Colitis, Ulcerative / Q000145:classification* / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies