Gingival eruption cysts induced by cyclosporine administration to neonatal dogs.
OBJECTIVE
The purpose of this paper is to report the development of extensive, gingival eruption cyst formation in neonatal dogs during chronic administration of cyclosporine, which regressed after treatment ceased.


METHODS
As part of an investigation of the efficacy of adenoviral-mediated gene therapy in a canine model of Duchenne Muscular Dystrophy (DMD), 26 Golden retriever pups were given intramuscular injections of adenoviral gene constructs (at 2-5 days old) either with (15 pups) or without (9 pups) concomitant immunosuppression using oral cyclosporine (from 1 to 3 days old).


RESULTS
The daily administration of cyclosporine to Golden Retriever pups from 1 to 3 days of age resulted in the formation of eruption cysts over the incisors after approximately 3 weeks of treatment. The gingiva over the remaining teeth became swollen. However unlike the incisors, part of the crown erupted through the gingiva. Continuous treatment for 60-90 days was associated with persistence and expansion of the cysts over the incisor teeth. The cysts resolved within 1 month if cyclosporine administration was discontinued. Movement of incisors within the jaws was not appreciably affected when compared with age-matched controls.


CONCLUSIONS
Chronic cyclosporine administration to neonatal dogs induces the formation of eruption cysts over the incisors, which is reversible once treatment is discontinued and does not affect intraosseous eruption.
O'Hara
Amanda J
AJ
Division of Veterinary and Biomedical Science, Murdoch University, Murdoch, Western Australia, Australia. aohara@central.murdoch.edu.au
Collins
Teresa
T
Howell
John M C
JM
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D000831:Animals, Newborn; D001641:Bicuspid / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003481:Cuspid / Q000187:drug effects; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D004195:Disease Models, Animal; D004285:Dogs; D004658:Enamel Organ / Q000187:drug effects / Q000473:pathology; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D015316:Genetic Therapy; D005822:Genetic Vectors; D005882:Gingival Diseases / Q000139:chemically induced* / Q000473:pathology; D005891:Gingivitis / Q000139:chemically induced / Q000473:pathology; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood; D007180:Incisor / Q000187:drug effects; D008297:Male; D008648:Mesoderm / Q000187:drug effects / Q000473:pathology; D008963:Molar / Q000187:drug effects; D009136:Muscular Dystrophies / Q000628:therapy; D009504:Neutrophils / Q000473:pathology; D009807:Odontogenic Cysts / Q000139:chemically induced* / Q000473:pathology; D012074:Remission Induction; D019228:Tooth Crown / Q000187:drug effects; D014078:Tooth Eruption / Q000187:drug effects
D007166:Immunosuppressive Agents; D016572:Cyclosporine