title: Denny-Brown, Wilson's disease, and BAL (British antilewisite [2,3-dimercaptopropanol]).
abstract: In 1951 Denny-Brown and Porter described the successful treatment of Wilson's disease using the chelating agent British antilewisite. The presentation of their results both at meetings and in print changed the traditional view of neurology from a descriptive to an interventional discipline using treatments based on the underlying biochemical disorder. The authors review the importance of these reports and provide edited digital versions of the films Denny-Brown made of the five patients described in the initial reports.
authors.affiliation: Department of Anatomy and Cell Biology, Indiana University School of Medicine, Fort Wayne, IN 46805, USA. vilensky@ipfw.edu
authors.forename: Joel A
authors.initials: JA
authors.lastname: Vilensky
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Robertson
authors.forename: Sid
authors.initials: S
authors.lastname: Gilman
mesh_terms: D004112:Dimercaprol / Q000266:history* / Q000627:therapeutic use; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D008297:Male; D009040:Motion Pictures / Q000266:history
chemical_list: D004112:Dimercaprol