Dermatomyositis in two siblings and a brief review of familial dermatomyositis.
Juvenile dermatomyositis is an uncommon autoimmune disease with classic heliotrope discoloration of the eyelids, erythematous skin rash of joints, and proximal muscle weakness. It is most frequently sporadic and only rarely familial. We present juvenile dermatomyositis in a 5-year-old brother and a 3 1/2-year-old sister, both are very responsive to corticosteroids. Familial dermatomyositis can occur in different family members, and even dermatomyositis and polymyositis can coexist in the same family.
Tsao
Chang-Yong
CY
Department of Pediatrics, The Ohio State University, Columbus, USA. ctsao@chi.osu.edu
Mendell
Jerry R
JR
Kissel
John T
JT
D002675:Child, Preschool; D003882:Dermatomyositis / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D035781:Siblings; D016896:Treatment Outcome
D005938:Glucocorticoids; D011241:Prednisone