title: Isotretinoin-induced nail fragility and onycholysis.
abstract: A 23 year old woman who presented with severe acne had been treated with 40 mg/day isotretinoin. On her monthly control, severe cheilitis and bilateral toe nail onycholysis were observed. It is well known that systemic retinoids have several side effects. Although dystropic nail, paronichia-like changes, median nail dystrophy have previously been reported with isotretinoin therapy, onycholysis is rare. In this report, we describe a case with isotretinoin induced nail fragility and onycholysis.
authors.affiliation: Gazi University Faculty of Medicine, Department of Dermatology, Besevler, Ankara, Turkey. monder@med.gazi.edu.tr
authors.forename: M
authors.initials: M
authors.lastname: Onder
authors.forename: M O
authors.initials: MO
authors.lastname: Oztaş
authors.forename: P
authors.initials: P
authors.lastname: Oztaş
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000009:adverse effects*; D009260:Nail Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin