title: Association between psoriasis severity and transforming growth factor beta(1) and beta (2) in plasma and scales from psoriatic lesions.
abstract: Psoriasis is an inflammatory skin disorder with hyperproliferation of keratinocytes, that can be the result of insufficient inhibitory effect of transforming growth factors-beta (TGF-beta). The aim of this study was to evaluate an association between TGF-beta(1) and -beta(2) in plasma or scales from psoriatic lesions and the severity of the disease. TGF-beta concentrations were measured with an enzyme immunoassay in 41 patients with psoriasis. The mean plasma concentrations of TGF-beta(1) and TGF-beta(2) in patients were: 15.7 +/- 1.4 and 0.15 +/- 0.02 ng/ml respectively. It was also detectable in scales and varied from 24 to 1159 and from 0 to 2.95 pg/mg protein respectively. Plasma TGF-beta(1) correlated significantly with psoriasis area and severity index (PASI). Significant correlation was also demonstrated between TGF-beta(1) concentration in scales and sedimentation rate or the disease duration. There were no correlation between PASI and plasma TGF-beta(2), scales TGF-beta(1) and TGF-beta(2). The highest mean concentration of TGF-beta(1) in scales of patients with mild form of the disease (203 +/- 65 pg/mg protein) and the lowest in severe form (147 +/- 54 pg/mg protein) have been shown. These findings demonstrated association between PASI and plasma levels of TGF-beta(1), that should be considered as a possible indicator of psoriasis activity.
authors.affiliation: Department of Dermatology and Venerology, Medical Acadamy, Bialystok, Sw Rocha, Poland. iflisiak@amb.ac.bialystok
authors.forename: Iwona
authors.initials: I
authors.lastname: Flisiak
authors.forename: Bozena
authors.initials: B
authors.lastname: Chodynicka
authors.forename: Piotr
authors.initials: P
authors.lastname: Porebski
authors.forename: Robert
authors.initials: R
authors.lastname: Flisiak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000145:classification* / Q000175:diagnosis*; D012867:Skin / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000097:blood*; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2
chemical_list: C508960:TGFB1 protein, human; C509041:TGFB2 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2