title: [Bladder cancer producing granulocyte colony-stimulating factor (G-CSF): a case report].
abstract: A case of bladder cancer producing granulocyte colony-stimulating factor (G-CSF) is reported. A 76-year-old male was admitted to our hospital with gross hematuria and leukocytosis. He was diagnosed with advanced bladder cancer. His white blood cell (WBC) count and serum granulocyte colony-stimulating factor (G-CSF) level were elevated (peak WBC 22,010/microliter, peak G-CSF 351 pg/ml), which immediately normalized after cystectomy. The histopathological diagnosis was transitional cell carcinoma, grade 3, pT4, pN1. Immunohistochemical examination was positive for G-CSF and G-CSF receptor. There has been no recurrence of cancer for more than 23 months since the operation without any additional therapy.
authors.affiliation: Department of Urology, Tuchiura Kyodo General Hospital.
authors.forename: Touko
authors.initials: T
authors.lastname: Asano
authors.forename: Shinji
authors.initials: S
authors.lastname: Morimoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kitami
authors.forename: Takaharu
authors.initials: T
authors.lastname: Miyauchi
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Sakai
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takagi
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000601:surgery; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000601:surgery; D014547:Urinary Diversion
chemical_list: D016179:Granulocyte Colony-Stimulating Factor