Assembly of polyamines via amino acids from three components using cobalt(III) template methodology.
A versatile and efficient template synthesis has been developed to synthesise novel polyamines [e.g. rac-N3-(3-aminopropyl)butane-1,3-diamine, isospermidine 1] via amino acids [e.g. (2R,4S/2S,4R)-N4-(3-aminopropyl)-2,4-diaminopentanoic acid] using cobalt(III) to assemble the three precursor components in a biomimetic manner.
Laval
Gilles
G
Department of Chemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne, UK NE1 7RU.
Clegg
William
W
Crane
Christopher G
CG
Hammershøi
Anders
A
Sargeson
Alan M
AM
Golding
Bernard T
BT
D000596:Amino Acids / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D011073:Polyamines; D003035:Cobalt