title: Tumor necrosis factor-alpha inhibits physiologically identified dorsal motor nucleus neurons in vivo.
abstract: Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric distention. A large majority of physiologically identified DMN neurons are rapidly and completely inhibited by exposure to TNF-alpha, suggesting that TNF-alpha may induce gastric stasis by functioning as a hormone that modulates both portions of this reflex pathway during illness.
authors.affiliation: Department of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Emch
authors.forename: Gerlinda E
authors.initials: GE
authors.lastname: Hermann
authors.forename: Richard C
authors.initials: RC
authors.lastname: Rogers
mesh_terms: D000818:Animals; D001710:Biotin / Q000031:analogs & derivatives*; D002404:Catheterization; D004396:Coloring Agents; D005110:Extracellular Space / Q000378:metabolism / Q000502:physiology; D008297:Male; D009046:Motor Neurons / Q000187:drug effects*; D010812:Physical Stimulation; D051381:Rats; D020318:Rats, Long-Evans; D012018:Reflex / Q000502:physiology; D017552:Solitary Nucleus / Q000502:physiology; D013238:Stereotaxic Techniques; D013270:Stomach / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014630:Vagus Nerve / Q000166:cytology / Q000187:drug effects*
chemical_list: D004396:Coloring Agents; D014409:Tumor Necrosis Factor-alpha; C070614:neurobiotin; D001710:Biotin