title: The development and evaluation of a three-dimensional ultrasound-guided breast biopsy apparatus.
abstract: We have designed a prototype three-dimensional ultrasound guidance (3D USB) apparatus to improve the breast biopsy procedure. Features from stereotactic mammography and free-hand US-guided biopsy have been combined with 3D US imaging. This breast biopsy apparatus accurately guides a needle into position for the sampling of target tissue. We have evaluated this apparatus in three stages. First, by testing the placement accuracy of a needle in a tissue mimicking phantom. Second, with tissue mimicking phantoms that had embedded lesions for biopsy. Finally, by comparison to free-hand US-guided biopsy, using chicken breast phantoms. The first two stages of evaluation quantified the mechanical biases in the 3D USB apparatus. Compensating for these, a 96% success rate in targeting 3.2 mm "lesions" in chicken breast phantoms was achieved when using the 3D USB apparatus. The expert radiologists performing biopsies with free-hand US guidance achieved a 94.5% success rate. This has proven an equivalence between our apparatus, operated by non-experts, and free-hand biopsy performed by expert radiologists, for 3.2 mm lesions in vitro, with a 95% confidence.
authors.affiliation: Imaging Research Laboratories, John P. Robarts Research Institute, PO Box 5015, 100 Perth Drive, London, Ontario, Canada N6A 5K8. kath@irus.rri.ca
authors.forename: K J M
authors.initials: KJ
authors.lastname: Surry
authors.forename: W L
authors.initials: WL
authors.lastname: Smith
authors.forename: L J
authors.initials: LJ
authors.lastname: Campbell
authors.forename: G R
authors.initials: GR
authors.lastname: Mills
authors.forename: D B
authors.initials: DB
authors.lastname: Downey
authors.forename: A
authors.initials: A
authors.lastname: Fenster
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000295:instrumentation* / Q000379:methods; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002645:Chickens; D003196:Computer Graphics; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D066298:In Vitro Techniques; D015233:Models, Statistical; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013238:Stereotaxic Techniques / Q000295:instrumentation*; D016217:Ultrasonography, Mammary / Q000295:instrumentation* / Q000379:methods