title: Cross-talk between hematopoiesis and angiogenesis signaling pathways.
abstract: The relationship between hematopoietic cells and endothelial cells has been seen as an indication that a common progenitor, the hemangioblast, gives rise to both cell types in the yolk sac, the initial site of hematopoiesis and blood vessel formation during mammalian development. The existence of angioblast-like circulating endothelial precursor cells in adults humans has recently been suggested. In this review, we have summarized the principle mechanisms involved in the cross-talk signaling pathway between hematopoiesis and angiogenesis in order to further understand how the hematopoietic and vascular systems are established during the development.
authors.affiliation: Department of Human Anatomy and Histology, University of Bari Medical School, Italy. ribatti@anatomia.uniba.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
authors.forename: Angelo
authors.initials: A
authors.lastname: Vacca
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nico
authors.forename: Roberto
authors.initials: R
authors.lastname: Ria
authors.forename: Franco
authors.initials: F
authors.lastname: Dammacco
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000196:embryology; D004727:Endothelium / Q000166:cytology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000196:embryology; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D014158:Transcription, Genetic