title: Local treatment of bacterial vaginosis with a bioadhesive metronidazole tablet.
abstract: OBJECTIVE
  Oral metronidazole is still the drug of choice in the treatment of bacterial vaginosis. Yet, side effects have been reported, and dosage as well as duration of therapy are still controversial. This study presents a possible alternative treatment using a single dose of metronidazole administered in a vaginal bioadhesive tablet.
  
  
  METHODS
  Double blind, randomised, placebo-controlled trial.
  
  
  METHODS
  The 116 patients were allocated to placebo; metronidazole 100; 250; 500mg in a 1:1:1:1 ratio.
  
  
  RESULTS
  A cure rate of 64% was obtained with a single 100mg dose of metronidazole formulated in a bioadhesive vaginal tablet compared to a cure rate of 29% in the placebo group. The cure rates with the higher doses were similar 61.5% for 250mg dose and 68% for the 500mg dose. No side effects were reported.
  
  
  CONCLUSIONS
  Treatment of bacterial vaginosis with a single application of 100mg metronidazole in a bioadhesive vaginal tablet was found to be a valid alternative. Further research in relation to tablet shaping and optimal dose finding might increase the cure rate.
authors.affiliation: Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B-9000, Ghent, Belgium.
authors.forename: Jody
authors.initials: J
authors.lastname: Voorspoels
authors.forename: Martine
authors.initials: M
authors.lastname: Casteels
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Remon
authors.forename: Marleen
authors.initials: M
authors.lastname: Temmerman
mesh_terms: D000268:Adhesiveness; D000282:Administration, Intravaginal; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D010919:Placebos; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D010919:Placebos; D008795:Metronidazole