title: The copper-catalyzed N-arylation of indoles.
abstract: A general method for the N-arylation of indoles using catalysts derived from CuI and trans-1,2-cyclohexanediamine (1a), trans-N,N'-dimethyl-1,2-cyclohexanediamine (2a), or N,N'-dimethyl-ethylenediamine (3) is reported. N-Arylindoles can be produced in high yield from the coupling of an aryl iodide or aryl bromide with a variety of indoles.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Jon C
authors.initials: JC
authors.lastname: Antilla
authors.forename: Artis
authors.initials: A
authors.lastname: Klapars
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003959:Diamines / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003959:Diamines; D007211:Indoles; D003300:Copper