Sodium cation complexation behavior of the heteroaromatic sidechains of histidine and tryptophan.
Three of the four essential amino acids that have aromatic sidechains exhibit cation-pi interactions with Na+ or K+; histidine does not and is shown here to be a sigma donor.
Hu
Jiaxin
J
Division of Bioorganic Chemistry, Bioorganic Chemistry Program, Department of Molecular Biology & Pharmacology, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8103, St. Louis, MO 63110, USA.
Barbour
Leonard J
LJ
Ferdani
Riccardo
R
Gokel
George W
GW
D002414:Cations, Monovalent / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry; D006639:Histidine / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D012964:Sodium / Q000737:chemistry*; D014364:Tryptophan / Q000737:chemistry*
D002414:Cations, Monovalent; D006571:Heterocyclic Compounds; D006639:Histidine; D014364:Tryptophan; D012964:Sodium