title: [The weakest link: medroxyprogesterone acetate in pig feed].
abstract: Medroxyprogesterone acetate (MPA)-contaminated feed arrested the onset of farrowing, and induced post-lactational anoestrus in sows. Sixty percent of the sows developed cystic ovaries after weaning following exposure to pharmaceutical waste of MPA in glucose syrup. This waste ended up in acidified feed of by-products of a sow farm, and proved to be the cause of the disorders. Analysis by thin layer chromatography and Gas Chromatography/Mass Spectrometry of renal fat from 10 slaughter sows demonstrated residues of 2.5-8 ppb of MPA. Within the European Union use of MPA is illegal as growth promoter in production animals, and therefore MPA-exposed farms were placed under official control by the general inspection service. Clinical signs and diagnostic procedures of the initial case are presented and the role of the veterinary practitioner in detecting potential food safety hazards is discussed.
authors.affiliation: Hoofdafdeling Gezondheidszorg Landbouwhuisdieren, Afdeling Varkensgezondheidszorg, Faculteit der Diergeneeskunde, Utrecht.
authors.forename: L
authors.initials: L
authors.lastname: van Leengoed
authors.forename: M
authors.initials: M
authors.lastname: Kluivers
authors.forename: R
authors.initials: R
authors.lastname: Herbes
authors.forename: P
authors.initials: P
authors.lastname: Langendijk
authors.forename: R
authors.initials: R
authors.lastname: Stephany
authors.forename: M
authors.initials: M
authors.lastname: van den Berg
authors.forename: W
authors.initials: W
authors.lastname: Seinen
authors.forename: G
authors.initials: G
authors.lastname: Grinwis
authors.forename: J
authors.initials: J
authors.lastname: van der Lugt
authors.forename: F
authors.initials: F
authors.lastname: Meulders
authors.forename: T
authors.initials: T
authors.lastname: Geudeke
authors.forename: J
authors.initials: J
authors.lastname: Verheijden
mesh_terms: D000780:Anestrus / Q000187:drug effects; D000821:Animal Feed; D000818:Animals; D002855:Chromatography, Thin Layer / Q000662:veterinary; D003257:Consumer Product Safety; D004350:Drug Residues / Q000032:analysis; D005260:Female; D005506:Food Contamination / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000662:veterinary; D007743:Labor, Obstetric / Q000187:drug effects; D007774:Lactation / Q000187:drug effects; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D010048:Ovarian Cysts / Q000139:chemically induced / Q000662:veterinary*; D011247:Pregnancy; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000009:adverse effects*; D012098:Reproduction / Q000187:drug effects*; D013552:Swine / Q000378:metabolism / Q000502:physiology*; D013553:Swine Diseases / Q000139:chemically induced*; D014018:Tissue Distribution
chemical_list: D045167:Progesterone Congeners; D017258:Medroxyprogesterone Acetate