title: Predictors of effective bilateral subthalamic nucleus stimulation for PD.
abstract: To identify factors predictive of effective bilateral subthalamic nucleus (STN) stimulation for PD with severe motor complications, pre- and postoperative Unified PD Rating Scale (UPDRS) scores were analyzed in a series of 54 patients who received bilateral STN stimulation. Younger age and levodopa responsiveness predict a favorable response to bilateral STN stimulation. For individual PD symptoms, those that improve with a suprathreshold dose levodopa challenge are likely to improve with stimulation.
authors.affiliation: Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France.
authors.forename: P D
authors.initials: PD
authors.lastname: Charles
authors.forename: N
authors.initials: N
authors.lastname: Van Blercom
authors.forename: P
authors.initials: P
authors.lastname: Krack
authors.forename: S L
authors.initials: SL
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.forename: G
authors.initials: G
authors.lastname: Besson
authors.forename: A-L
authors.initials: AL
authors.lastname: Benabid
authors.forename: P
authors.initials: P
authors.lastname: Pollak
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D004599:Electric Stimulation Therapy / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D011300:Preoperative Care / Q000706:statistics & numerical data; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D020531:Subthalamic Nucleus / Q000601:surgery*
chemical_list: D007980:Levodopa