title: Acute infectious purpura fulminans associated with asplenism or hyposplenism.
abstract: Acute infectious purpura fulminans is a rapidly progressive syndrome of hemorrhagic skin necrosis associated with acute infection and disseminated intravascular coagulation. We report 5 cases of purpura fulminans and briefly review the literature. All cases were associated with encapsulated organisms (Streptococcus pneumoniae or Group A streptococcus), and 4 of the 5 patients had asplenism or functional hyposplenism.
authors.affiliation: Department of Dermatology, Columbia University, The New York Presbyterian Hospital, New York, USA.
authors.forename: Kimberley Morine
authors.initials: KM
authors.lastname: Ward
authors.forename: Julide Tok
authors.initials: JT
authors.lastname: Celebi
authors.forename: Robyn
authors.initials: R
authors.lastname: Gmyrek
authors.forename: Marc E
authors.initials: ME
authors.lastname: Grossman
mesh_terms: D000208:Acute Disease; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000209:etiology / Q000382:microbiology; D008875:Middle Aged; D013154:Spleen / Q000002:abnormalities*