title: Asymmetric functional divergence of duplicate genes in yeast.
abstract: Most duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Here, I present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if asymmetrically diverging duplicate gene pairs show increased robustness to deleterious mutations.
authors.affiliation: Department of Biology, University of New Mexico, Albuquerque, USA. wagnera@unm.edu
authors.forename: Andreas
authors.initials: A
authors.lastname: Wagner
mesh_terms: D004777:Environment; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000235:genetics; D020440:Gene Duplication; D015870:Gene Expression; D005800:Genes, Fungal; D016681:Genome, Fungal; D008957:Models, Genetic; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D020798:Two-Hybrid System Techniques
chemical_list: D005656:Fungal Proteins