title: Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.
abstract: Parallel synthesis was used to explore the SAR of a peptidomimetic caspase inhibitor. The most potent compound had nanomolar activity against caspases 1, 3, 6, 7, and 8.
authors.affiliation: Idun Pharmaceuticals, Inc., 9380 Judicial Drive, San Diego, CA 92121, USA. slinton@idun.com
authors.forename: Steven D
authors.initials: SD
authors.lastname: Linton
authors.forename: Donald S
authors.initials: DS
authors.lastname: Karanewsky
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ternansky
authors.forename: Joe C
authors.initials: JC
authors.lastname: Wu
authors.forename: Brian
authors.initials: B
authors.lastname: Pham
authors.forename: Lalitha
authors.initials: L
authors.lastname: Kodandapani
authors.forename: Robert
authors.initials: R
authors.lastname: Smidt
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Diaz
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Fritz
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Tomaselli
mesh_terms: D000215:Acylation; D061945:Caspase Inhibitors; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D061945:Caspase Inhibitors; D004151:Dipeptides; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D007527:Isoenzymes; D009842:Oligopeptides