title: Biliary excretion of taurolithocholate-sulfate and temocaprilat in cholestatic rats induced by bile duct-ligation and ethinylestradiol.
abstract: Down-regulation of multidrug resistance protein 2 (Mrp2), a major canalicular organic anion transporter, has been reported in various cholestatic models and in patients with cholestasis. In the present study, biliary excretion of taurolithocholate-sulfate and temocaprilat, substrates of Mrp2, was studied in bile duct-ligated rats and in cholestatic rats induced by ethinylestradiol (EE). Biliary excretion of temocaprilat was more markedly decreased in bile duct-ligated rats than that of taurolithocholate-sulfate. In contrast, biliary excretion of both compounds were similarly inhibited in EE-treated rat. Such difference of the degree of inhibition may have been caused by the different degree of the inhibition of unknown canalicular transporters other than Mrp2 in bile duct-ligated rats.
authors.affiliation: Department of Medicine, Teikyo University School of Medicine, Kaga 2-11-1, Itabashi-ku, 173, Tokyo, Japan
authors.forename: Hajime
authors.initials: H
authors.lastname: Takikawa
authors.forename: Naoyo
authors.initials: N
authors.lastname: Sano
authors.forename: Toshiki
authors.initials: T
authors.lastname: Onishi
authors.forename: Atsuko
authors.initials: A
authors.lastname: Toda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Hojo
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Marumo
authors.forename: Naoko
authors.initials: N
authors.lastname: Hanawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Tachizawa
authors.forename: Kou
authors.initials: K
authors.lastname: Nishikawa