title: Polymyositis: clinical investigation in two sisters.
abstract: We present an investigation of a case of polymyositis affecting two sisters of one same parenthood. Their cases have been documented for almost two decades, being investigated by means of a diagnostic protocol which combined clinical findings as well as laboratorial, histopathological and image tests. In both cases, clinical manifestations started in childhood, without signs of involvement of the central and peripheral nervous system. Both patients proved to respond to a therapeutics based on corticosteroids. The degree of relatedness between their parents corroborate the notion that genetic factors may contribute to the development of the disease.
authors.affiliation: Department of Physiotherapy, Catholic University of Brasilia, Brasilia, DF, Brasil.
authors.forename: Margô Gomes de Oliveira
authors.initials: MG
authors.lastname: Karnikowski
authors.forename: Bruno Rodrigues Veloso
authors.initials: BR
authors.lastname: Costa
authors.forename: Oscar Francisco Sanchez
authors.initials: OF
authors.lastname: Osella
authors.forename: Otávio Tolêdo
authors.initials: OT
authors.lastname: Nóbrega
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006801:Humans; D008297:Male; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D017285:Polymyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D035781:Siblings
chemical_list: D000305:Adrenal Cortex Hormones; D005634:Fructose-Bisphosphate Aldolase