title: Equivalence of branched and unbranched Michaelian pathways concerning periodic signal transmission.
abstract: Sinusoidal oscillation transmission through branched metabolic pathways is studied. Two systems are analyzed, which are composed of two convergent reaction branches and differ in the length of one of them. Linear kinetics is assumed first. Michaelis-Menten enzymes are then considered by using previous results that suggest their behavior with respect to propagation of oscillations is close to linearity around the mean input flux. As a result, there exist ways to modulate the activity of the enzymes so that propagation is equivalent for branched and specific unbranched pathways. Cells may have taken advantage of such a possibility in cases where oscillations have a biological role.
authors.affiliation: Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias Quimicas, Universidad Complutense, Madrid Spain.
authors.forename: Yoel
authors.initials: Y
authors.lastname: Rodríguez
authors.forename: Antonio S
authors.initials: AS
authors.lastname: Torralba
authors.forename: Francisco
authors.initials: F
authors.lastname: Montero
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D010507:Periodicity; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004798:Enzymes