A null association between active or passive cigarette smoking and breast cancer risk.
The effect of smoking on breast cancer risk has been null in large, well-conducted cohort studies. In a previous study, we stratified the population into active smokers, passive smokers, and never-active never-passive smokers and modeled early life cigarette smoke exposures as causal and later life cigarette smoke exposure as preventive. We observed a complex association between cigarette smoke and breast cancer risk. Using a similar design and population, this study did not confirm the earlier result. Neither ever-active smoking (adjusted odds ratio (OR) = 0.72, 95% confidence intervals (CI) 0.55-0.95) nor ever-passive smoking (adjusted OR = 0.85, 95% CI 0.63-1.1) were strongly associated with breast cancer risk compared with never-active never-passive smoking. No patterns of effects were observed in subgroup analyses.
Lash
Timothy L
TL
Boston University School of Public Health, MA, USA. tlash@bu.edu
Aschengrau
Ann
A
D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008404:Massachusetts / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D014028:Tobacco Smoke Pollution / Q000706:statistics & numerical data
D014028:Tobacco Smoke Pollution