title: Cytotoxic activity of aminoderivatized cationic chitosan derivatives.
abstract: Chitosan derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. In this study, the cytotoxic activity of the chitosan derivatives was investigated and a relationship between structure and activity is suggested. The cationic chitosan derivatives elicited dose-dependent inhibitory effects on the proliferation of tumor cell lines.
authors.affiliation: BioNgene Co., Ltd., 10-1, 1Ka Myungryun-Dong, Chongro-Ku, Seoul, South Korea.
authors.forename: Jung-Kul
authors.initials: JK
authors.lastname: Lee
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Lim
authors.forename: Jung-Hoe
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D002686:Chitin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D048271:Chitosan; D004983:Ethanolamines; D006801:Humans; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004983:Ethanolamines; D007202:Indicators and Reagents; D002686:Chitin; D048271:Chitosan; C007369:2-diethylaminoethanol