The complexity of chromatin remodeling and its links to cancer.
The relief of chromatin-mediated repression by ATP-dependent chromatin-remodeling complexes is an important step in the proper transcriptional regulation of many genes. This review gives an organized summary of this large group of complexes that exist in yeast, flies, and humans. Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented.
Neely
Kristen E
KE
Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 306 Althouse Laboratory, University Park, PA 16802, USA.
Workman
Jerry L
JL
D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000145:classification; D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism*; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000737:chemistry; D004330:Drosophila; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins; D015513:Oncogene Proteins / Q000737:chemistry; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000737:chemistry; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000378:metabolism*; D014981:Xenopus
C489847:CHD1 protein, S cerevisiae; D002843:Chromatin; D004268:DNA-Binding Proteins; C086468:ISWI protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins; C499336:SMARCA1 protein, human; C084011:SMARCA2 protein, human; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C106555:rsc protein, Oryctolagus cuniculus; D000251:Adenosine Triphosphatases; C084108:SMARCA4 protein, human; C499333:SNF2 protein, S cerevisiae; D004265:DNA Helicases; C080359:CHD1 protein, human