Molecular mechanisms of B-lymphocyte transformation by Epstein-Barr virus.
The B-lymphotropic virus Epstein-Barr virus (EBV) has been implicated in the pathogenesis of B-cell malignancies, particularly in immunodeficient individuals. This review provides a brief overview of the EBV-encoded proteins involved in B-cell transformation, and the current state of knowledge about their roles in this process.
Bishop
Gail A
GA
Department of Microbiology, 3-570 Bowen Science Bldg., The University of Iowa, Iowa City, IA 52242, USA. gail-bishop@uiowa.edu
Busch
Lisa K
LK
D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000821:virology*; D002472:Cell Transformation, Viral; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D016867:Immunocompromised Host; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D014764:Viral Proteins / Q000378:metabolism
D014764:Viral Proteins