Biodegradation and biocompatibility of polyorganophosphazene.
We investigated biodegradation and biocompatibility of poly(organophosphazenes). We prepared poly(organophosphazenes) having different side chain groups. The blood compatibility of poly(organophosphazenes) containing fluorinated side groups, poly(bis[trifluoroethoxy]phosphazene) (PbFP) and poly([trifluoroethoxy][ethyl glycinate]phosphazene) (PFGP), without heparinization were evaluated in vitro. The deformation and aggregation of platelets adhered on PbFP and PFGP were not observed and they suppressed platelet activation. Additionally, PbFP and PFGP showed a higher degradation rate, despite their high hydrophobic nature. We found that the high mobility of water in PbFP and PFGP was one of the important factors facilitating their degradation. Their polymer structures were formed in a more open nature, indicating that water easily attacked the backbone of the phosphorus and nitrogen atoms in the poly(organophosphazene). On the other hand, the proliferation of HeLa cells cultured on poly(organophosphazene) was reduced compared with that on the control tissue culture polystyrene.
Kawakami
Hiroyoshi
H
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan. kawakami-hiroyoshi@c.metro-u.ac.jp
Kanezaki
Shota
S
Sudo
Miyuki
M
Kanno
Masayoshi
M
Nagaoka
Shoji
S
Kubota
Sunao
S
D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics*; D001673:Biodegradation, Environmental; D006801:Humans; D066298:In Vitro Techniques; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D010753:Phosphoranes / Q000737:chemistry / Q000493:pharmacokinetics*; D010973:Platelet Adhesiveness / Q000187:drug effects; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013997:Time Factors
D001672:Biocompatible Materials; D009943:Organophosphorus Compounds; D010753:Phosphoranes; C022601:hexachlorocyclotriphosphazene