title: How often are nonenhancing supratentorial gliomas malignant? A population study.
abstract: The presence of contrast enhancement in a brain tumor is often regarded as a sign of malignancy. The authors identified 314 patients with malignant and low-grade supratentorial glial neoplasms in an unselected population, 58 of which lacked contrast enhancement on preoperative neuroimaging. Nonenhancing gliomas were malignant in approximately one third of cases, especially in older patients. Histologic confirmation of the diagnosis is therefore important in all patients suspected of harboring a primary glial neoplasm.
authors.affiliation: Department of Diagnostic Imaging, University of Calgary, Alberta, Canada.
authors.forename: J N
authors.initials: JN
authors.lastname: Scott
authors.forename: P M A
authors.initials: PM
authors.lastname: Brasher
authors.forename: R J
authors.initials: RJ
authors.lastname: Sevick
authors.forename: N B
authors.initials: NB
authors.lastname: Rewcastle
authors.forename: P A
authors.initials: PA
authors.lastname: Forsyth
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000416:Alberta / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005910:Glioma / Q000453:epidemiology* / Q000473:pathology*; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015173:Supratentorial Neoplasms / Q000453:epidemiology* / Q000473:pathology*