Autonomic cardiovascular reflexes in Wilson's disease.
We studied autonomic cardiovascular function in fourteen patients with Wilson's disease. Four had abnormalities on autonomic testing and, of these, three had evidence of severe central nervous system abnormalities. In contrast, of the remaining ten patients with normal cardiovascular reflexes, only two had severe deficits of the central nervous system. We suggest that autonomic impairment in Wilson's disease is due to involvement of central autonomic neurons.
Bhattacharya
Kirsty
K
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Velickovic
Miodrag
M
Schilsky
Michael
M
Kaufmann
Horacio
H
D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001479:Basal Ganglia / Q000378:metabolism / Q000473:pathology; D002319:Cardiovascular System / Q000294:innervation*; D003300:Copper / Q000378:metabolism; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012018:Reflex / Q000502:physiology*
D003300:Copper