title: Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' children.
abstract: Children of farmers are at decreased risk of developing allergies. Results of epidemiological studies suggest increased exposure to microbial compounds might be responsible for this reduced risk. Alterations in adaptive immune response are thought to be the underlying mechanism. We measured expression of receptors for microbial compounds known to trigger the innate immune response. We showed that blood cells from farmers' children express significantly higher amounts of CD14 (0.96 vs 0.43, p=0.0013), and Toll-like receptor 2 (0.11 vs 0.04, p<0.0001) than those from non-farmers' children. We propose that the innate immune system responds to the microbial burden in the environment and modulates the development of allergic disease.
authors.affiliation: Zurich University Children's Hospital, CH-8032 Zürich, Switzerland. rlauener@kispi.unizh.ch
authors.forename: Roger P
authors.initials: RP
authors.lastname: Lauener
authors.forename: Thomas
authors.initials: T
authors.lastname: Birchler
authors.forename: Jill
authors.initials: J
authors.lastname: Adamski
authors.forename: Charlotte
authors.initials: C
authors.lastname: Braun-Fahrländer
authors.forename: Albrecht
authors.initials: A
authors.lastname: Bufe
authors.forename: Udo
authors.initials: U
authors.lastname: Herz
authors.forename: Erika
authors.initials: E
authors.lastname: von Mutius
authors.forename: Dennis
authors.initials: D
authors.lastname: Nowak
authors.forename: Josef
authors.initials: J
authors.lastname: Riedler
authors.forename: Marco
authors.initials: M
authors.lastname: Waser
authors.forename: Felix H
authors.initials: FH
authors.lastname: Sennhauser
mesh_terms: D000383:Agriculture; D002648:Child; D029721:Drosophila Proteins; D004781:Environmental Exposure; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007110:Immunity, Active; D007113:Immunity, Innate; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008562:Membrane Glycoproteins / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood*; D051195:Toll-Like Receptor 2; D051193:Toll-Like Receptors
chemical_list: D029721:Drosophila Proteins; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D051193:Toll-Like Receptors