ECA: control in ecosystems.
Although metabolic control analysis (MCA) cannot be applied directly to microbial ecological systems because of mass conservation and stoichiometric constraints, we demonstrate here that Hierarchical Control Analysis (HCA) can be applied to such systems. We illustrate the approach for a particular ecosystem example of the biological synthesis of acetic acid from glucose, and uncover some surprising aspects to the control of this miniature ecosystem.
Westerhoff
Hans V
HV
Stellenbosch Institute for Advanced Study, Amsterdam. hw@bio.vu.nl
Getz
Wayne M
WM
Bruggeman
Frank
F
Hofmeyr
Jan-Hendrik S
JH
Rohwer
Johann M
JM
Snoep
Jacky L
JL
D019342:Acetic Acid / Q000378:metabolism; D000091:Acetobacter / Q000254:growth & development / Q000378:metabolism; D000818:Animals; D004463:Ecology; D017753:Ecosystem; D005947:Glucose / Q000378:metabolism; D008433:Mathematics; D008954:Models, Biological; D015003:Yeasts / Q000254:growth & development / Q000378:metabolism
D005947:Glucose; D019342:Acetic Acid