Agrin in the developing CNS: new roles for a synapse organizer.
The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer's disease is accumulating.
Kröger
Stephan
S
Institute for Physiological Chemistry and Pathobiochemistry, University of Mainz, D-55099 Mainz, Germany.
Schröder
Jörn E
JE
D018171:Agrin / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D002490:Central Nervous System / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D013569:Synapses / Q000502:physiology*
D018171:Agrin