Diagnostic implications of circulating oxidized low density lipoprotein levels as a biochemical risk marker of coronary artery disease.
OBJECTIVE
To examine the diagnostic performance of circulating oxidized low density lipoprotein levels as a biochemical risk marker of coronary heart disease.


METHODS
361 patients with coronary artery disease and 710 healthy volunteers as normal controls were examined. Receiver-operating characteristics curve analysis in addition to statistical analysis (univariate, multivariate) were done to determine the usefulness of the assay.


RESULTS
Patients with coronary artery disease showed significantly elevated circulating oxidized low density lipoprotein levels. Males less than 70 years of age showed a significant association between oxidized low density lipoprotein levels and coronary artery disease. Receiver-operating characteristics curve analysis showed superior performance (e.g., sensitivity, specificity) of oxidized low density lipoprotein as a diagnostic marker of coronary artery disease as compared against other lipid markers (total cholesterol, triglyceride, high density lipoprotein, lipoprotein (a), and total cholesterol to high density lipoprotein ratio) with optimal performance in younger males.


CONCLUSIONS
Oxidized low density lipoprotein levels may be a promising biochemical risk marker of atherosclerotic disease, especially in young males.
Suzuki
Toru
T
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Kohno
Hiroaki
H
Hasegawa
Akira
A
Toshima
Shunichi
S
Amaki
Toshihiro
T
Kurabayashi
Masahiko
M
Nagai
Ryozo
R
Suzuki
Toru
T
Amaki
Toshihiro
T
Nagai
Ryozo
R
Hasegawa
Akira
A
Toshima
Shunichi
S
Kurabayashi
Masa-hiko
MH
Shimada
Kazuyuki
K
Nakamura
Haruo
H
Teramoto
Tamio
T
Yamaguchi
Hiroshi
H
Nishiyama
Shin-ichiro
S
Takahashi
Hakuo
H
Michishita
Ichiro
I
Sugano
Zinpei
Z
Konoshi
Keiko
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012044:Regression Analysis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein