title: [Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants].
abstract: OBJECTIVE
  To investigate the role of hepatitis B virus (HBV) DNA levels in HBV-carrier mother and selective transmission of HBV variant with S gene mutation to infant in the failure of neonatal HBV immunization.
  
  
  METHODS
  Serum HBV DNA level was determined by Roche LightCycler quantities in 95 HBsAg-positive pregnant women and later in their newborns. Hepatitis B virus S gene sequences isolated from mother/child pairs were analyzed in 7 cases which did not respond to HBV vaccination and hepatitis B immunoglobulin.
  
  
  RESULTS
  HBV infection was identified in 7.4 % of the infants during their first year after birth. The levels of HBV DNA in the mothers of the infected infants were higher than those of the uninfected group, and selective transmission of HBV variant from mother to infant was observed.
  
  
  CONCLUSIONS
  HBV DNA levels in HBV-carrier mother and selective transmission of HBV variant from mother to infant contribute to the failure of neonatal HBV immunization.
authors.affiliation: Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhan-hui
authors.initials: ZH
authors.lastname: Wang
authors.forename: Jin-lin
authors.initials: JL
authors.lastname: Hou
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Ai-lin
authors.initials: AL
authors.lastname: Cheng
authors.forename: Xiu-hui
authors.initials: XH
authors.lastname: Li
mesh_terms: D000328:Adult; D002353:Carrier State / Q000635:transmission / Q000821:virology; D004279:DNA, Viral / Q000097:blood / Q000737:chemistry; D005260:Female; D014644:Genetic Variation; D006509:Hepatitis B / Q000097:blood / Q000517:prevention & control / Q000635:transmission*; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D009154:Mutation; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D017422:Sequence Analysis, DNA; D014611:Vaccination
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines