Protein degradation with photoactivated enediyne-amino acid conjugates.
A series of photoactivated enediynes was prepared, and successfully employed for the selective degradation of target proteins.
Plourde
Gary
G
Department of Chemistry, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
El-Shafey
Ahmed
A
Fouad
Farid S
FS
Purohit
Ajay S
AS
Jones
Graham B
GB
D004249:DNA Damage / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D006657:Histones / Q000737:chemistry / Q000187:drug effects; D007202:Indicators and Reagents; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010777:Photochemistry; D011506:Proteins / Q000737:chemistry / Q000187:drug effects*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000187:drug effects
D006657:Histones; D007202:Indicators and Reagents; D009844:Oligosaccharides; D011506:Proteins; D011743:Pyrimidines; D012710:Serum Albumin, Bovine