A case-control study of HIV-1-related dementia and co-infection with HHV-8.
This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HIV-infected cases and nondemented HIV-infected controls.
Polk
S
S
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Muñoz
A
A
Sacktor
N C
NC
Jenkins
F J
FJ
Cohen
B
B
Miller
E N
EN
Jacobson
L P
LP
D015526:AIDS Dementia Complex / Q000097:blood / Q000453:epidemiology* / Q000821:virology; D000328:Adult; D016022:Case-Control Studies; D016001:Confidence Intervals; D015497:HIV-1; D019288:Herpesvirus 8, Human; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012514:Sarcoma, Kaposi / Q000097:blood / Q000453:epidemiology* / Q000821:virology