title: Role of magnetic resonance imaging in the diagnosis and single-stage surgical resection of invasive lobular carcinoma of the breast.
abstract: BACKGROUND
  Conventional imaging with mammography and ultrasonography has a low sensitivity for diagnosis and a tendency to underestimate the extent of invasive lobular carcinoma (ILC) of the breast. The aim was to determine whether magnetic resonance imaging (MRI) had any advantages for the characterization of ILC.
  
  
  METHODS
  Twenty patients with histologically proven ILC underwent preoperative imaging with MRI. MRI was performed to aid detection of malignancy in six patients with a clinically suspicious presentation but normal or indeterminate imaging on mammography and ultrasonography. In 14 patients MRI was performed to determine tumour extent.
  
  
  RESULTS
  MRI accurately identified malignancy in five of six patients with normal or indeterminate conventional imaging. In seven of 14 patients in whom MRI was performed to determine tumour extent, it provided significant additional information. These included four patients in whom conventional imaging grossly underestimated tumour size, two patients in whom MRI identified an unsuspected contralateral breast tumour and one patient in whom MRI predicted tumour invasion of the pectoral muscle. The correlation between tumour size on histological examination was better with MRI (r = 0.967) than with mammography (r = 0.663) and ultrasonography (r = 0.673).
  
  
  CONCLUSIONS
  MRI can provide considerable additional information in the detection and characterization of ILC.
authors.affiliation: Department of Surgery, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK.
authors.forename: K
authors.initials: K
authors.lastname: Munot
authors.forename: B
authors.initials: B
authors.lastname: Dall
authors.forename: R
authors.initials: R
authors.lastname: Achuthan
authors.forename: G
authors.initials: G
authors.lastname: Parkin
authors.forename: S
authors.initials: S
authors.lastname: Lane
authors.forename: K
authors.initials: K
authors.lastname: Horgan
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods