[Effect of bushenjiannao 1 decoction on learning and memory functions and anti-fatigue ability in mice].
OBJECTIVE
To observe the anti-dementia effect of Bushenjiannao 1 decoction on mice.


METHODS
The learning and memory tests were realized with a water maze on the learning and memory impact of mice induced by scopolamine and cycloheximide. The effect of Bushenjiannao 1 decoction on the independent activity and anti-fatigue ability of mice were also investigated.


RESULTS
Bushenjiannao 1 decoction used at a medium dose of 15 g crude drug/kg and a higher dose of 45 g crude drug/kg could significantly improve the learning and memory abilities of mice injected with scopolamine. Higher doses could improve these abilities of mice injected with cycloheximide, and also improve the anti-fatigue ability of mice. No significant differences were observed in the independent activity of mice between the groups.


CONCLUSIONS
Bushenjiannao 1 decoction helps improve the learning and memory abilities and enhance the anti-fatigue ability, but has no effect on excitability of the central nervous system.
Li
B
B
Xuanwu Hospital, Beijing Brain Aging Key Laboratory, Beijing 100053.
Li
L
L
Zhang
L
L
Cheng
T
T
Li
Z
Z
Liao
F
F
Li
W
W
D000818:Animals; D003513:Cycloheximide; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005221:Fatigue / Q000188:drug therapy*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008517:Phytotherapy; D012601:Scopolamine
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D003513:Cycloheximide; D012601:Scopolamine