title: Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.
abstract: A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.
authors.affiliation: Bristol-Myers Squibb PRI, PO Box 4000, Princeton, NJ 08543-4000, USA. scott.watterson@bms.com
authors.forename: Scott H
authors.initials: SH
authors.lastname: Watterson
authors.forename: Chunjian
authors.initials: C
authors.lastname: Liu
authors.forename: T G Murali
authors.initials: TG
authors.lastname: Dhar
authors.forename: Henry H
authors.initials: HH
authors.lastname: Gu
authors.forename: William J
authors.initials: WJ
authors.lastname: Pitts
authors.forename: Joel C
authors.initials: JC
authors.lastname: Barrish
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Fleener
authors.forename: Katherine
authors.initials: K
authors.lastname: Rouleau
authors.forename: N Z
authors.initials: NZ
authors.lastname: Sherbina
authors.forename: Diane L
authors.initials: DL
authors.lastname: Hollenbaugh
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Iwanowicz
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000473:pathology; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D007202:Indicators and Reagents; D007168:IMP Dehydrogenase