HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP).
OBJECTIVE
There is growing indication that differences in host response determine susceptibility and resistance to periodontal disease. Particularly, the effect of histocompatibility antigens (HLA) on early onset periodontitis (EOP) has been studied. As most of the results are not conclusive and to date no report has been done on German patients, the aim of this study was to investigate the distribution of HLA alleles in a group of 50 German RPP patients and 102 German AP patients and to compare them to 102 control probands without periodontitis.


METHODS
Diagnosis was established according to standardised clinical criteria. HLA typing was performed using serologic and molecular biologic (PCR-SSP) techniques.


RESULTS
Compared to the controls, RPP patients had a significantly higher frequency of HLA-DRB1*13 and a significantly lower frequency of HLA-DRBblank*(non-DRB3/4/5). AP patients showed a significantly increased occurrence of HLA-B*14 and -Cw*08 as well as a significantly decreased frequency of HLA-A*03. In both patient groups HLA-A*11 and -A*29 had an increased frequency and HLA-A*31 and -A*30/31 were decreased. These differences were statistical significant in the whole patient group (RPP + AP).


CONCLUSIONS
Based on modern DNA techniques the present study shows an association of HLA to both RPP and AP. Certain HLA alleles seem to be associated with susceptibility or resistance to periodontitis in general. However, before this knowledge can be used for differential diagnosis or prognosis, further investigations are necessary.
Machulla
H K G
HK
Interbranch HLA Laboratory/Department GHATT, Institute of Medical Immunology, Martin Luther University, Halle, Germany. helmut.machulla@medizin.uni-halle.de
Stein
J
J
Gautsch
A
A
Langner
J
J
Schaller
H-G
HG
Reichert
S
S
D000328:Adult; D010520:Aggressive Periodontitis / Q000276:immunology; D000483:Alleles; D016301:Alveolar Bone Loss / Q000145:classification / Q000276:immunology; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D004198:Disease Susceptibility; D005787:Gene Frequency / Q000235:genetics; D005858:Germany; D005884:Gingival Hemorrhage / Q000145:classification / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D059845:HLA-DRB4 Chains; D059847:HLA-DRB5 Chains; D006801:Humans; D017622:Periodontal Attachment Loss / Q000145:classification / Q000276:immunology; D010518:Periodontitis / Q000145:classification / Q000276:immunology*; D010641:Phenotype; D013223:Statistics as Topic
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; C524551:HLA-C*08 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D059845:HLA-DRB4 Chains; D059847:HLA-DRB5 Chains; D004247:DNA