title: A laboratory study of an inactivated bivalent iron restricted Salmonella enterica serovars Enteritidis and Typhimurium dual vaccine against Typhimurium challenge in chickens.
abstract: A commercial inactivated iron restricted Salmonella Typhimurium and Salmonella Enteritidis vaccine was used to vaccinate chicks at 1 day and again at 4 weeks of age, with challenge by a high and a low dose of S. Typhimurium given either orally or by contact with seeder birds inoculated orally with a high dose of S. Typhimurium. In all three challenge regimes, the shedding of challenge strain was reduced significantly (p < 0.05) in vaccinated birds compared with unvaccinated controls. Vaccination reduced colonisation of internal organs after challenge by contact seeder birds. However, no effect of vaccination upon colonisation of internal organs after either high or low oral challenge was apparent. In conclusion, the data indicate that the vaccine should be a useful tool in the control of S. Typhimurium infection in chickens.
authors.affiliation: Department of Bacterial Diseases, Veterinary Laboratories Agency--Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK.
authors.forename: F A
authors.initials: FA
authors.lastname: Clifton-Hadley
authors.forename: M
authors.initials: M
authors.lastname: Breslin
authors.forename: L M
authors.initials: LM
authors.lastname: Venables
authors.forename: K A
authors.initials: KA
authors.lastname: Sprigings
authors.forename: S W
authors.initials: SW
authors.lastname: Cooles
authors.forename: S
authors.initials: S
authors.lastname: Houghton
authors.forename: M J
authors.initials: MJ
authors.lastname: Woodward
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002645:Chickens; D002988:Cloaca / Q000382:microbiology; D015169:Colony Count, Microbial / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007501:Iron / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D011897:Random Allocation; D022562:Salmonella Vaccines / Q000276:immunology* / Q000592:standards; D012477:Salmonella enteritidis / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*; D018709:Statistics, Nonparametric; D014611:Vaccination / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D022562:Salmonella Vaccines; D007501:Iron