Oxidative stress and chronic renal failure: markers and management.
New reliable oxidative stress markers are present in chronic renal failure (CRF) patients, indicating that CRF is a pro-oxidant state. However, the pathogenesis of oxidative stress in CRF patients remains poorly defined. Moreover, the limited data available provide no clear-cut evidence in favor of the clinical benefit of antioxidant manoeuvres aimed at reducing cardiovascular disease in CRF patients or in the general population as well. Therefore, no practical recommendations can be given at this stage, and further studies are clearly needed.
Massy
Ziad A
ZA
Division of Nephrology, CH Beauvais, INSERM U507, Necker Hospital, Paris, France. massy@necker.fr
Nguyen-Khoa
Thao
T
D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D002986:Clinical Trials as Topic; D015237:Dinoprost / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005609:Free Radicals / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D007975:Leukotriene B4 / Q000032:analysis; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000032:analysis; D006435:Renal Dialysis / Q000379:methods; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014801:Vitamin A / Q000627:therapeutic use*
D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D017382:Reactive Oxygen Species; D014801:Vitamin A; D007975:Leukotriene B4; D008315:Malondialdehyde; D015237:Dinoprost