Benzodiazepine inhibitors of the MMPs and TACE.
A series of benzodiazepine inhibitors of the MMPs and TACE has been developed. These compounds display an interesting selectivity profile and should be useful tools for exploring the biological relevance of such selectivity.
Nelson
Frances C
FC
Wyeth Research, 401N. Middletown Road, Pearl River, NY 10965, USA. nelson@wyeth.com
Delos Santos
Efren
E
Levin
Jeremy I
JI
Chen
James M
JM
Skotnicki
Jerauld S
JS
DiJoseph
John F
JF
Sharr
Michele A
MA
Sung
Amy
A
Killar
Loran M
LM
Cowling
Rebecca
R
Jin
Guixian
G
Roth
Catherine E
CE
Albright
J Donald
JD
D051722:ADAM Proteins; D000072198:ADAM17 Protein; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000494:pharmacology*; D002356:Cartilage / Q000187:drug effects / Q000201:enzymology; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D011719:Pyrazines; D013329:Structure-Activity Relationship; D013449:Sulfonamides
C097658:CGS 27023A; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D011719:Pyrazines; D013449:Sulfonamides; D001569:Benzodiazepines; D051722:ADAM Proteins; D008666:Metalloendopeptidases; D000072198:ADAM17 Protein