Predictors of effective bilateral subthalamic nucleus stimulation for PD.
To identify factors predictive of effective bilateral subthalamic nucleus (STN) stimulation for PD with severe motor complications, pre- and postoperative Unified PD Rating Scale (UPDRS) scores were analyzed in a series of 54 patients who received bilateral STN stimulation. Younger age and levodopa responsiveness predict a favorable response to bilateral STN stimulation. For individual PD symptoms, those that improve with a suprathreshold dose levodopa challenge are likely to improve with stimulation.
Charles
P D
PD
Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France.
Van Blercom
N
N
Krack
P
P
Lee
S L
SL
Xie
J
J
Besson
G
G
Benabid
A-L
AL
Pollak
P
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D004599:Electric Stimulation Therapy / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D011300:Preoperative Care / Q000706:statistics & numerical data; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D020531:Subthalamic Nucleus / Q000601:surgery*
D007980:Levodopa