title: Application of self-assembly techniques in the design of biocompatible protein microarray surfaces.
abstract: This review focuses on the application of novel technologies for generating biocompatible surfaces for high-throughput screening (HTS) of proteins. Various methods of coupling and spotting proteins on self-assembled monolayer (SAM) surfaces will be described along with the protein chip challenges pertaining to spot homogeneity, morphology, biocompatibility and reproducibility.
authors.affiliation: University of Regensburg, Institute of Analytical Chemistry, Chemo- and Biosensors, Regensburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Schaeferling
authors.forename: Stefan
authors.initials: S
authors.lastname: Schiller
authors.forename: Hubert
authors.initials: H
authors.lastname: Paul
authors.forename: Margit
authors.initials: M
authors.lastname: Kruschina
authors.forename: Petra
authors.initials: P
authors.lastname: Pavlickova
authors.forename: Mark
authors.initials: M
authors.lastname: Meerkamp
authors.forename: Chiara
authors.initials: C
authors.lastname: Giammasi
authors.forename: Dev
authors.initials: D
authors.lastname: Kambhampati
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D018914:Cells, Immobilized; D003911:Dextrans / Q000737:chemistry; D015180:Electrophoresis, Gel, Two-Dimensional / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D005898:Glass; D008051:Lipid Bilayers / Q000737:chemistry; D008422:Materials Testing; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D008051:Lipid Bilayers