title: The first synthesis and antifungal activities of 9-methoxystrobilurin-type beta-substituted beta-methoxyacrylate.
abstract: The first synthesis of 9-methoxystrobilurin-type beta-substituted MOAs was successfully achieved. A chiral oudemansin-type beta-substituted MOA was also synthesized utilizing Mukaiyama's asymmetric aldol reaction. Antifungal activities of the synthesized compounds against several representative fungi were examined by disk-diffusion assay. As a result, unique and superior antifungal properties of 9-methoxystrobilurin-type beta-substituted MOAs compared with those of oudemansin-type analogue were clearly revealed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 12 Ichigayafunagawara-machi, Shinjuku-ku, Tokyo, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Uchiro
authors.forename: Koh
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kotake
authors.forename: Daiju
authors.initials: D
authors.lastname: Hasegawa
authors.forename: Aya
authors.initials: A
authors.lastname: Tomita
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D007202:Indicators and Reagents; D007476:Ionophores; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000494:pharmacology
chemical_list: C101802:9-methoxystrobilurin L; D000179:Acrylates; D000935:Antifungal Agents; D004148:Dioxolanes; D007202:Indicators and Reagents; D007476:Ionophores; D009761:Nystatin; C023324:oudemansin