Polymeric complexes of lidocaine hydrochloride with poly(acrylic acid) and poly(2-hydroxyethyl vinyl ether).
The specific interactions of local anesthetic lidocaine hydrochloride with poly(acrylic acid) and poly(2-hydroxyethyl vinyl ether), as well as in a triple system composed of the drug and both polymers, have been studied in aqueous solutions by viscometric, turbidimetric, potentiometric, and FTIR spectroscopic methods. The mechanism of the drug binding to the polymers and the structures of the polycomplexes formed are clarified.
Nurkeeva
Zauresh S
ZS
Kazakh National University, Department of Chemical Physics and Macromolecular Chemistry, Almaty. khutor@nursat.kz
Mun
Grigoriy A
GA
Khutoryanskiy
Vitaliy V
VV
Bitekenova
Asem B
AB
Dzhusupbekova
Aizhan B
AB
D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry; D000779:Anesthetics, Local / Q000138:chemical synthesis / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D008012:Lidocaine / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D046911:Macromolecular Substances; D008970:Molecular Weight; D011145:Polyvinyls / Q000138:chemical synthesis* / Q000737:chemistry; D011199:Potentiometry; D017550:Spectroscopy, Fourier Transform Infrared
D000180:Acrylic Resins; D000779:Anesthetics, Local; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D046911:Macromolecular Substances; D011145:Polyvinyls; C006903:carbopol 940; D008012:Lidocaine