[Tumor angiogenesis--value and significance in squamous epithelial carcinoma of the mouth cavity].
Angiogenesis is an essential condition for the development and proliferation of malignant tumors larger than 3 mm3. Furthermore, the development of new blood vessels is necessary for the growth of metastases in the target organ. A relationship between angiogenic factors and stage of disease was shown for different types of malignancies whereas the data available for oral cancer are limited. This prospective study evaluates 51 primary untreated squamous cell carcinoma of the oral cavity. The expression of angiogenic factors in tumor tissue and normal oral mucosa tissue was investigated immunohistochemically by frozen and paraffin embedded tissue specimen. In addition, blood serum and plasma was evaluated for the expression of soluble angiogenic factors over a time period of 5 weeks postoperative (ELISA technique). A control group of 10 patients without evidence of malignant disease and operated on in general anesthesia was defined. The data evaluation shows significant less blood vessels in T1 cancer in comparison to T2, T3 and T4 tumors. No further significant relationships could be shown either immunohistochemically nor with ELISA's. A ratio between the investigated soluble angiogenic factors and the expression of the factors in tumor specimen could not be proven. The results of this study and the data available in the literature demonstrate only a subordinate impact of angiogenesis on the classification and prognosis of squamous cell carcinoma of the oral cavity. At the moment, no isolated or combined therapy strategies including antiangiogenic procedures for the treatment of oral cancer can be derived.
Schimming
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R
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie/Plastische Operationen, Universitätsklinikum Freiburg i. Brsg., Hugstetterstr. 55, 79106 Freiburg i. Brsg. ronald_schimming@zmk2.ukl.uni-freiburg.de
D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D009062:Mouth Neoplasms / Q000098:blood supply* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis