[Comparative genomics and proteomics of Drosophila, Brenner's nematode, and Arabidopsis: identification of functionally similar genes and proteins of meiotic chromosome synapsis].
The published principles of computer analysis of genomes and protein sets in taxonomically distant eukaryotes are expounded. The authors developed a search strategy to identify in genomes of such organisms genes and proteins nonhomologous in primary structure but having similar functions in cells dividing by meiosis. This strategy based on the combined principles of genomics, proteomics, and morphometric analysis of subcellular structures was applied to a computer search for genes encoding the proteins of synaptonemal complexes in genomes of Drosophila melanogaster, the nematode Caenorhabditis elegans, and the plant Arabidopsis thaliana. These proteins proved to be functionally similar to their counterparts in yeast Saccharomyces cerevisiae (protein Zip1p) and mammals (protein SCP1).
Bogdanov
Iu F
IuF
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991 Russia. bogdanov@vigg.ru
Dadashev
S Ia
SIa
Grishaeva
T M
TM
D000818:Animals; D017360:Arabidopsis / Q000235:genetics*; D029681:Arabidopsis Proteins / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D023902:Chromosome Pairing / Q000502:physiology*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics; D023281:Genomics / Q000379:methods*; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D012984:Software; D040681:Structural Homology, Protein; D013573:Synaptonemal Complex / Q000235:genetics
D029681:Arabidopsis Proteins; D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C090118:Zip1 protein, S cerevisiae