Intestinal bile acids can bind to and activate the vitamin D receptor.
An increased level of colon lithocholic acid, a potential tumor promoter, accompanies a high-fat diet. Lithocholic acid can bind to the intestinal vitamin D receptor and thereby induce the cytochrome CYP3A, which detoxifies lithocholic acid by catabolic reactions.
Wolf
George
G
Department of Nutritional Sciences and Toxicology, University of California, Berkeley 94720-3104, USA.
D001647:Bile Acids and Salts / Q000494:pharmacology*; D006801:Humans; D007422:Intestines / Q000502:physiology*; D008095:Lithocholic Acid / Q000494:pharmacology; D018167:Receptors, Calcitriol
D001647:Bile Acids and Salts; D018167:Receptors, Calcitriol; D008095:Lithocholic Acid