Association of nonsyndromic Wilms tumor with premature centromere division (PCD).
Wilms tumor was discovered in a 22-month-old otherwise healthy girl. Her pretreatment karyotype proved to be normal 46,XX with total premature division (PCD) in 21% of her lymphocyte mitoses. This phenomenon was not seen in the parents. PCD was found in less than 4% of lymphocyte mitoses of five other children with Wilms tumor. The individual finding provides further evidence for a relation of PCD to tumorigenesis; however, elucidation of the question needs further systematic studies.
Méhes
K
K
MTA-PTE Research Group of Clinical Genetics, University of Pécs, Hungary. karoly.mehes@aok.pte.hu
Kajtár
P
P
Kosztolányi
G
G
D002503:Centromere / Q000502:physiology*; D002873:Chromosome Fragility; D005260:Female; D006801:Humans; D007223:Infant; D009396:Wilms Tumor / Q000235:genetics*