title: Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae).
abstract: Anti-inflammatory activity of an ethanolic extract from Bouchea fluminensis leaves was demonstrated. From de ethanolic extract, the active compound was isolated and characterized as the iridoid lamiide. The activity of lamiide on rat-brain phospholipid peroxidation showed a powerful effect (IC(50)=0.92+/-0.01 mM) and an anti-inflammatory activity in carrageenin-induced paw edema test (ED(50)=62.3+/-7 mg/kg weight).
authors.affiliation: Instituto Superior de Ciências Farmacêuticas e Bioquímica, Universidade Paranaense, Umuarama, Paraná, Brazil. delaporte@uol.com.br
authors.forename: Rosemeres Horwat
authors.initials: RH
authors.lastname: Delaporte
authors.forename: Gregorio Martínez
authors.initials: GM
authors.lastname: Sánchez
authors.forename: Armando Cuellar
authors.initials: AC
authors.lastname: Cuellar
authors.forename: Attilia
authors.initials: A
authors.lastname: Giuliani
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Palazzo de Mello
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D029648:Verbenaceae / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D039823:Iridoids; D010936:Plant Extracts