The first synthesis and antifungal activities of 9-methoxystrobilurin-type beta-substituted beta-methoxyacrylate.
The first synthesis of 9-methoxystrobilurin-type beta-substituted MOAs was successfully achieved. A chiral oudemansin-type beta-substituted MOA was also synthesized utilizing Mukaiyama's asymmetric aldol reaction. Antifungal activities of the synthesized compounds against several representative fungi were examined by disk-diffusion assay. As a result, unique and superior antifungal properties of 9-methoxystrobilurin-type beta-substituted MOAs compared with those of oudemansin-type analogue were clearly revealed.
Uchiro
Hiromi
H
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 12 Ichigayafunagawara-machi, Shinjuku-ku, Tokyo, Japan.
Nagasawa
Koh
K
Kotake
Tomoya
T
Hasegawa
Daiju
D
Tomita
Aya
A
Kobayashi
Susumu
S
D000179:Acrylates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D007202:Indicators and Reagents; D007476:Ionophores; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000494:pharmacology
C101802:9-methoxystrobilurin L; D000179:Acrylates; D000935:Antifungal Agents; D004148:Dioxolanes; D007202:Indicators and Reagents; D007476:Ionophores; D009761:Nystatin; C023324:oudemansin