Extensive pulmonary infiltration by leukemic blasts successfully treated with hydroxyurea--a case report.
The initial presentation of acute leukemia as diffuse pulmonary infiltrates, especially with respiratory distress, is relatively infrequent and poses a therapeutic dilemma. Here we report a case of acute myeloid leukemia with diffuse pulmonary infiltration and respiratory distress symptom as the initial presentation that responded to hydroxyurea dramatically. This case demonstrates that hydroxyurea can be used effectively to decrease blast cell count and resolve leukemic infiltration of both lungs in patients with acute myeloblastic leukemia.
Huang
Po-Hsun
PH
Department of Medicine, Taipei-Veterans General Hospital, National Yang-Ming University, Taiwan.
You
Jie-Yu
JY
Hsu
Hui-Chi
HC
D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001752:Blast Crisis / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage*; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology*; D017254:Leukemic Infiltration / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D012074:Remission Induction; D012128:Respiratory Distress Syndrome / Q000209:etiology; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D006918:Hydroxyurea