[Experience with the combination atovaquone-proguanil in the treatment of uncomplicated Plasmodium falciparum malaria--report of 112 cases].
The purpose of this open non-comparative retrospective study was to evaluate the efficacy and tolerance of Malarone for management of uncomplicated imported Plasmodium falciparum malaria. A total of 112 non-immune adult patients were included between 1999 and 2001. Excellent responses in terms of both clinical symptoms and parasite control were achieved within 4 days after the beginning of treatment in all cases. No recurrence was observed after 28 days of individual followup. Tolerance was satisfactory with no adverse events except for occasional, minor gastrointestinal upset. Based on our experience, Malarone appears to be effective, well-tolerated, and suitable for routine management of uncomplicated imported Plasmodium falciparum malaria.
Malvy
D
D
Service de Médecine interne et des Maladies tropicales, Hôpital Saint-André, 1 rue Jean-Burguet, 33 075 Bordeaux. jean-marie-denis.malvy@chu-bordeaux.fr
Djossou
F
F
Vatan
R
R
Pistone
Th
T
Etienne
G
G
Longy-Boursier
M
M
Le Bras
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D053626:Atovaquone; D004359:Drug Therapy, Combination; D005260:Female; D005756:Gastritis / Q000139:chemically induced; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009285:Naphthoquinones / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D002727:Proguanil / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
D000962:Antimalarials; D009285:Naphthoquinones; D002727:Proguanil; D053626:Atovaquone