Metabolic effects of contraceptive steroids. III. Intravenous glucose tolerance--short term observations.
Intravenous glucose tolerance tests were carried out in women taking 2 types of estrogen/progestogen combination oral contraceptives.  Each subject had the test done on days 18-21 in a control cycle before the medication was begun and 3 consecutive cycles during administration of the drug.  Fasting blood glucose levels and K values showed no significant changes with a combination of megestrol acetate (4 mg) with 0.05 mg of ethinyl estradiol.  A significant decline in glucose tolerance was observed by the change in K values during all 3 cycles of medication with a combination of 2.5 mg lynestrenol and 0.075 mg mestranol.  Tests repeated 2 months after stoppage of the medication in 5 subjects showed that blood sugar levels and K values had returned to pretreatment levels.
Mangat
H K
HK
Chaudhury
R R
RR
Devi
P K
PK
D000367:Age Factors; D001208:Asia; D001695:Biology; D001835:Body Weight; D002241:Carbohydrates; D019411:Clinical Laboratory Techniques; D003267:Contraception; D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D003906:Developing Countries; D003933:Diagnosis; D004997:Ethinyl Estradiol; D005193:Family Planning Services; D005947:Glucose; D005951:Glucose Tolerance Test; D007194:India; D008234:Lynestrenol; D019290:Megestrol Acetate; D008597:Menstrual Cycle; D008656:Mestranol; D008660:Metabolism; D010298:Parity; D010827:Physiology; D011154:Population Characteristics; D011203:Poverty
D002241:Carbohydrates; D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D004997:Ethinyl Estradiol; D008656:Mestranol; D005947:Glucose; D008234:Lynestrenol; D019290:Megestrol Acetate
Age Factors; Asia; Biology; Body Weight; Carbohydrate Metabolic Effects; Contraception; Contraceptive Agents, Estrogen; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Progestin; Contraceptive Agents--administraction and dosage; Contraceptive Methods--side effects; Developing Countries; Ethinyl Estradiol--administraction and dosage; Examinations And Diagnoses; Family Planning; Glucose Metabolism Effects; Glucose Tolerance Test--analysis; India; Laboratory Examinations And Diagnoses; Laboratory Procedures; Low Income Population; Lynestrenol--administraction and dosage; Megestrol Acetate--administraction and dosage; Menstrual Cycle; Mestranol--administraction and dosage; Metabolic Effects; Oral Contraceptives--side effects; Parity; Physiology; Population Characteristics; Southern Asia