Oral antimicrobial susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates from Japanese children.
The minimum inhibitory concentrations (MICs) of 11 oral antibiotics were measured for 140 Streptococcus pneumoniae, 115 Haemophilus influenzae, and 46 Moraxella catarrhalis strains isolated from Japanese children. The antibiotics selected included a range of commonly prescribed agents together with a selection of new cefems and a penem. Cefditoren was most active against the highly penicillin resistant S. pneumoniae, beta-lactamase-producing H. influenzae and beta-lactamase-negative ampicillin-resistant H. influenzae. However, amoxycillin retained good activity against the penicillin-susceptible or -intermediately resistant S. pneumoniae (88.6%) and most of ampicillin-susceptible or -intermediately resistant H. influenzae (87.9%). We thus consider that amoxycillin remains a useful initial choice for the treatment of paediatric respiratory infections in Japan.
Nishi
Junichiro
J
Department of Pediatrics, Faculty of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Japan. nishi1@m2.kufm.kagoshima-u.ac.jp
Yoshinaga
Masao
M
Tokuda
Koichi
K
Masuda
Kaori
K
Masuda
Ryuji
R
Kamenosono
Akira
A
Manago
Kunihiro
K
Miyata
Koichiro
K
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects*; D011008:Pneumococcal Infections / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000900:Anti-Bacterial Agents