title: 3',4'-trans-linked bicyclic nucleosides locked in S-type conformations.
abstract: A novel class of 3',4'-trans-linked bicyclic nucleosides with locked S-type furanose conformations is introduced by synthesis of two model derivatives; one was obtained by cyclic ether formation and the other by ring-closing metathesis methodology.
authors.affiliation: Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230, Odense M, Denmark.
authors.forename: Helena
authors.initials: H
authors.lastname: Thomasen
authors.forename: Michael
authors.initials: M
authors.lastname: Meldgaard
authors.forename: Morten
authors.initials: M
authors.lastname: Freitag
authors.forename: Michael
authors.initials: M
authors.lastname: Petersen
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
authors.forename: Poul
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D003500:Cyclization; D004988:Ethers, Cyclic / Q000737:chemistry; D008968:Molecular Conformation; D009705:Nucleosides / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D009705:Nucleosides