[Effect of nicotinamide adenine dinucleotide on the serotoninergic mediator system in the rat brain during 3-acetylpyridine administration].
The effect of administration of 3-acetylpyridine (antivitamin B3), on rat brain serotoninergic and NAD receptor systems was investigated. The injection of 3-acetylpyridine to rats caused a decrease of NAD and serotonin content in the brain and changes in [U-14C]NAD binding to synaptic membranes, serotonin uptake by nerve endings, as well as sensitivity of this process to NAD (10-5 M). Pretreatment of animals with nicotinamide restored modulating effect of NAD.
Kuchmerovskaia
T M
TM
Palladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovich Street, Kiev, 01601 Ukrane. kuch@biochem.kiev.ua
Chichkovskaia
G V
GV
Pakirbaeva
L V
LV
Khalmuradov
A A
AA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000494:pharmacology; D011485:Protein Binding; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism
D011725:Pyridines; C010835:3-acetylpyridine; D009243:NAD; D009536:Niacinamide; D012701:Serotonin