On the role of mi-cK and VDAC in mitochondrial function of heart muscle cells.
A two-compartment kinetic model was used to describe reconstituted systems in which mitochondria compete with pyruvate kinase for kinase-generated ADP. The modelling suggests that cytosolic CK deficiency results in a 50% increase in outer mitochondrial membrane permeability.
ter Veld
Frank
F
Dept of Experimental In-Vivo NMR, Image Sciences Institute, UMC Utrecht. frank@invivonmr.uu.nl
Bruggeman
Frank
F
Jeneson
Jeroen
J
Nicolay
Klaas
K
D000818:Animals; D003402:Creatine Kinase / Q000235:genetics / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008929:Mitochondria, Heart / Q000201:enzymology*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism*; D018272:Porins / Q000378:metabolism*; D011770:Pyruvate Kinase / Q000378:metabolism; D050994:Voltage-Dependent Anion Channels
D007527:Isoenzymes; D018272:Porins; D050994:Voltage-Dependent Anion Channels; D011770:Pyruvate Kinase; D003402:Creatine Kinase