Application of self-assembly techniques in the design of biocompatible protein microarray surfaces.
This review focuses on the application of novel technologies for generating biocompatible surfaces for high-throughput screening (HTS) of proteins. Various methods of coupling and spotting proteins on self-assembled monolayer (SAM) surfaces will be described along with the protein chip challenges pertaining to spot homogeneity, morphology, biocompatibility and reproducibility.
Schaeferling
Michael
M
University of Regensburg, Institute of Analytical Chemistry, Chemo- and Biosensors, Regensburg, Germany.
Schiller
Stefan
S
Paul
Hubert
H
Kruschina
Margit
M
Pavlickova
Petra
P
Meerkamp
Mark
M
Giammasi
Chiara
C
Kambhampati
Dev
D
D001672:Biocompatible Materials / Q000737:chemistry; D018914:Cells, Immobilized; D003911:Dextrans / Q000737:chemistry; D015180:Electrophoresis, Gel, Two-Dimensional / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D005898:Glass; D008051:Lipid Bilayers / Q000737:chemistry; D008422:Materials Testing; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods*; D013499:Surface Properties
D001672:Biocompatible Materials; D003911:Dextrans; D008051:Lipid Bilayers