title: Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles.
abstract: The antioxidant effect of resveratrol (3,4',5-trihydroxy-trans-stilbene) and its analogues, that is, 4-hydroxy-trans-stilbene (4-HS), 3,5-dihydroxy-trans-stilbene (3,5-DHS), 4,4'-dihydroxy-trans-stilbene (4,4'-DHS), 3,4-dihydroxy-trans-stilbene (3,4-DHS), 3,4,5-trihydroxy-trans-stilbene (3,4,5-THS) and 3,4,4'-trihydroxy-trans-stilbene (3,4,4'-THS), against the peroxidation of linoleic acid has been studied in sodium dodecyl sulfate (SDS) and cetyltrimethyl ammonium bromide (CTAB) micelles. The peroxidation was initiated thermally by a water-soluble azo initiator 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH), and the reaction kinetics were studied by monitoring the formation of linoleic acid hydroperoxides. The synergistic antioxidant effect of these compounds with alpha-tocopherol (vitamin E) was also studied by following the decay kinetics of alpha-tocopherol and the reaction intermediate, the alpha-tocopheroxyl radical. Kinetic analysis of the antioxidant process demonstrates that these compounds are effective antioxidants in micelles used either alone or in combination with alpha-tocopherol. The antioxidative action involves trapping the propagating lipid peroxyl radical and reducing the alpha-tocopheroxyl radical to regenerate alpha-tocopherol. It was found that the antioxidant activity of resveratrol analogues depends significantly on the position of the hydroxyl groups, the oxidation potential of the molecule and the reaction medium. Molecules with ortho-dihydroxyl and/or para-hydroxyl functionalities possess high activity.
authors.affiliation: National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Fang
authors.forename: Man
authors.initials: M
authors.lastname: Lu
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Chen
authors.forename: Hui-He
authors.initials: HH
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Long-Min
authors.initials: LM
authors.lastname: Wu
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D004563:Electrochemistry; D005609:Free Radicals / Q000737:chemistry*; D007700:Kinetics; D019787:Linoleic Acid / Q000737:chemistry*; D015227:Lipid Peroxidation; D008823:Micelles; D015394:Molecular Structure; D000077185:Resveratrol; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry*; D014920:Wine; D024502:alpha-Tocopherol / Q000737:chemistry
chemical_list: D000975:Antioxidants; D002593:Cetrimonium Compounds; D005609:Free Radicals; D008823:Micelles; D013267:Stilbenes; D012967:Sodium Dodecyl Sulfate; D019787:Linoleic Acid; D024502:alpha-Tocopherol; D000077185:Resveratrol; D000077286:Cetrimonium