title: Minimal residual low-grade gastric MALT-type lymphoma after eradication of Helicobacter pylori.
abstract: Helicobacter pylori eradication is the initial treatment of choice in localised low-grade gastric MALT (mucosa-associated lymphoid-tissue)-type lymphoma. We describe the natural course of seven patients who refused further oncological treatment for persistent lymphoma after successful eradication of H pylori. Despite persistent clonality, neither lymphoma progression nor high-grade transformation arose during a mean observation period of 34 (range 22-44) months. In view of the favourable course of these patients, a watch-and-wait strategy could be a valid approach to management of this disease.
authors.affiliation: Department of Internal Medicine II, Klinikum Aschaffenburg, 63739 Aschaffenburg, Germany. wolfgang.fischback@klinikum-aschaffenbug.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Fischbach
authors.forename: Mariele
authors.initials: M
authors.lastname: Goebeler-Kolve
authors.forename: Petr
authors.initials: P
authors.lastname: Starostik
authors.forename: Axel
authors.initials: A
authors.lastname: Greiner
authors.forename: Hans Konrad
authors.initials: HK
authors.lastname: Müller-Hermelink
mesh_terms: D000328:Adult; D000368:Aged; D017291:Clarithromycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000188:drug therapy / Q000382:microbiology; D009853:Omeprazole / Q000008:administration & dosage
chemical_list: D008795:Metronidazole; D017291:Clarithromycin; D009853:Omeprazole