title: Randomised controlled trial of cognitive-behavioural therapy in early schizophrenia: acute-phase outcomes.
abstract: BACKGROUND
  Cognitive-behavioural therapy (CBT) improves persistent psychotic symptoms.
  
  
  OBJECTIVE
  To test the effectiveness of added CBT in accelerating remission from acute psychotic symptoms in early schizophrenia.
  
  
  METHODS
  A 5-week CBT programme plus routine care was compared with supportive counselling plus routine care and routine care alone in a multi-centre trial randomising 315 people with DSM-IV schizophrenia and related disorders in their first (83%) or second acute admission. Outcome assessments were blinded.
  
  
  RESULTS
  Linear regression over 70 days showed predicted trends towards faster improvement in the CBT group. Uncorrected univariate comparisons showed significant benefits at 4 but not 6 weeks for CBT v. routine care alone on Positive and Negative Syndrome Scale total and positive sub-scale scores and delusion score and benefits v. supportive counselling for auditory hallucinations score.
  
  
  CONCLUSIONS
  CBT shows transient advantages over routine care alone or supportive counselling in speeding remission from acute symptoms in early schizophrenia.
authors.affiliation: School of Psychiatry and Behavioural Sciences, University of Manchester, Wythenshawe Hospital, Manchester M23 9LT, UK.
authors.forename: S
authors.initials: S
authors.lastname: Lewis
authors.forename: N
authors.initials: N
authors.lastname: Tarrier
authors.forename: G
authors.initials: G
authors.lastname: Haddock
authors.forename: R
authors.initials: R
authors.lastname: Bentall
authors.forename: P
authors.initials: P
authors.lastname: Kinderman
authors.forename: D
authors.initials: D
authors.lastname: Kingdon
authors.forename: R
authors.initials: R
authors.lastname: Siddle
authors.forename: R
authors.initials: R
authors.lastname: Drake
authors.forename: J
authors.initials: J
authors.lastname: Everitt
authors.forename: K
authors.initials: K
authors.lastname: Leadley
authors.forename: A
authors.initials: A
authors.lastname: Benn
authors.forename: K
authors.initials: K
authors.lastname: Grazebrook
authors.forename: C
authors.initials: C
authors.lastname: Haley
authors.forename: S
authors.initials: S
authors.lastname: Akhtar
authors.forename: L
authors.initials: L
authors.lastname: Davies
authors.forename: S
authors.initials: S
authors.lastname: Palmer
authors.forename: B
authors.initials: B
authors.lastname: Faragher
authors.forename: G
authors.initials: G
authors.lastname: Dunn
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D010349:Patient Compliance; D012559:Schizophrenia / Q000628:therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome