title: Clinical and radiographic spectrum of septic pulmonary embolism.
abstract: OBJECTIVE
  To review the clinical presentation, radiographic findings, and outcome of therapy in children with septic pulmonary embolism.
  
  
  METHODS
  Retrospective analysis of patients in a tertiary paediatric facility in northern Taiwan.
  
  
  RESULTS
  Ten children were identified with septic pulmonary emboli in a four year retrospective chart review between 1998 and 2001. Seven were immunocompetent, two were premature infants, one had beta thalassemia major. Seven had community acquired staphylococcal infections and bacteraemia, of which six were methicillin resistant Staphylococus aureus (MRSA) isolates. Five had soft tissue infections, two bone infections, one suppurative otitis media, one catheter related infection, and one unknown foci of infection. Multiple and bilateral nodular pulmonary parenchymal lesions were common on plain chest radiographs, but chest computed tomography scans showed the additional findings of a "vessel sign" and central cavitations, confirming the existence of septic pulmonary embolism.
  
  
  CONCLUSIONS
  Community acquired MRSA infections occurred in seven patients with septic pulmonary embolism but without predisposing high risk factors. Critically ill children with skin, soft tissue, or bone infections, when associated with septic pulmonary embolism in an area with a high rate of MRSA, should be empirically treated with glycopeptides (such as vancomycin or teicoplanin) before susceptibility results are known, in order to minimise morbidity and avoid mortality.
authors.affiliation: Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan. pchest@adm.cgmh.org.tw
authors.forename: K S
authors.initials: KS
authors.lastname: Wong
authors.forename: T Y
authors.initials: TY
authors.lastname: Lin
authors.forename: Y C
authors.initials: YC
authors.lastname: Huang
authors.forename: S H
authors.initials: SH
authors.lastname: Hsia
authors.forename: P H
authors.initials: PH
authors.lastname: Yang
authors.forename: S M
authors.initials: SM
authors.lastname: Chu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000382:microbiology / Q000628:therapy; D008297:Male; D016106:Methicillin Resistance; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000382:microbiology* / Q000628:therapy; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000150:complications*; D013211:Staphylococcus aureus / Q000187:drug effects; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome