title: HIV-1 reservoirs.
abstract: In most infected individuals, HIV-1 replicates high levels throughout the duration of infection, including the clinically quiescent phase of disease. The level of this active viral replication correlates directly with disease progression and survival. The advent of combination therapeutics for HIV-1 (i.e., highly active antiretroviral therapy [HAART]) has led to dramatic reductions in viral replication in vivo and morbidity and mortality, at least in the developed world.
authors.affiliation: Dorrance H. Hamilton Laboratory, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA. roger.j.pomerantz@mail.tju.edu
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Pomerantz
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018450:Disease Progression; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007109:Immunity / Q000187:drug effects; D014779:Virus Replication / Q000502:physiology
chemical_list: D019380:Anti-HIV Agents