[Histochemical changes in endometrial fibrolytic activity with different IUDs].
The histochemical changes of endometrial fibrinolytic activity were observed in rabbits.  1 horn of the uterus was put in IUDs made of different materials (steel, copper, magnet, and EACA-copper).  It was found that the endometrial fibrinolytic activity in the experimental horns was significantly higher than the controls, and the effect was the highest with the copper IUD.  In the contrasted groups (copper versus steel, copper versus magnet, steel versus magnet), the endometrial fibrinolytic activity induced by the copper IUD was the highest (P0.05), while there was no significant diffeence between that of steel and magnet (P0.05).  In the EACA-copper IUD groups, the results were also observed on days 7, 14, and 28 after insertion of the devices.  There was no difference in fibrinolytic activity between the experimental horns and the controls in 7 and 14 days groups, but it was significantly higher than the controls in 28 days group.  In the contrasted groups of the EACA-copper IUD and copper IUD the endometrial fibrinolytic activity of the former was lower than that of the latter in 7 days group (0.05 P  0.1).  This suggests that fibrinolytic activity may be inhibited by EACA, which, however, may be released from IUD at such a rapid rate that it loses its effect in 28 days.
Lu
Q
Q
Zheng
X Q
XQ
Liu
Q X
QX
Kong
R Z
RZ
Feng
H Z
HZ
D000830:Animals, Laboratory; D001695:Biology; D001769:Blood; D001777:Blood Coagulation; D003267:Contraception; D004467:Economics; D004717:Endometrium; D005069:Evaluation Studies as Topic; D005193:Family Planning Services; D005342:Fibrinolysis; D005835:Genitalia; D005836:Genitalia, Female; D007434:Intrauterine Devices; D010827:Physiology; D012106:Research; D013672:Technology; D014566:Urogenital System; D014599:Uterus
Animals, Laboratory; Biology; Blood Coagulation Effects; Clinical Research; Contraception; Contraceptive Methods; Economic Factors; Endometrial Effects; Endometrium; Evaluation; Family Planning; Fibrinolysis; Genitalia; Genitalia, Female; Hematological Effects; Hemic System; Iud; Physiology; Research And Development; Research Methodology; Technology; Urogenital System; Uterus