Psychotropic drug induced male infertility: a case report.
This is a case report of a 35-year old man whose fertility status was severely impaired by a past history of bilateral testicular torsion, use of numerous psychotropic drugs, and the presence of a left varicocele. A moderate improvement in the semen quality occurred following discontinuation of the medications, but a significant reponse was not evident until a varicocelectomy was performed. Thereafter, repeated semen analyses revealed normal findings except for a marked depression of sperm motility when the patient took Norpramin, a psychoactive drug.  Seminal factors were consistently normal when this medication was withheld.  Ultimately, when the patient agreed not to take the Norpramin for 9 months, his semen quality remained normal and his wife conceived and delivered a normal male child.
Getzoff
P L
PL
D001695:Biology; D003625:Data Collection; D005835:Genitalia; D005837:Genitalia, Male; D007246:Infertility; D004364:Pharmaceutical Preparations; D010827:Physiology; D012098:Reproduction; D012106:Research; D012661:Semen; D012669:Seminal Vesicles; D013076:Sperm Count; D013094:Spermatozoa; D013812:Therapeutics; D014566:Urogenital System
D004364:Pharmaceutical Preparations
Biology; Case Histories; Data Collection; Drugs--side effects; Genitalia; Genitalia, Male; Infertility--etiology; Infertility--men; Physiology; Reproduction; Research Methodology; Semen--analysis; Seminal Vesicles; Sperm Count; Spermatozoa; Treatment; Urogenital System