[Experimental study on antiendotoxin effect of extracts from Artemisia annua L].
OBJECTIVE
To explore the antiendotoxin effect of extracts from Artemisia annua (AA) and qinghaosu (QHS).


METHODS
LPO and SOD in chondriosome, ACP in lysosomes, tumor nicrosis factor-alpha(TNF-alpha) and endotoxin in plasma, and P450 concentration in hepatic microsome of rats were determined. Mortality of endotoxemic mice and histomorphology were observed.


RESULTS
LPO, ACP, endotoxin, TNF-alpha and P450 content were decreased with AA and QHS. SOD activity was increased with AA and QHS. At the same time, mortality was decreased. Histomorphology of lysosomes and chondriosome of rats were protected from endotoxin.


CONCLUSIONS
AA and QHS possess an antiendotoxin effect.
Tan
Y
Y
Hospital 303 of PLA, Nanning 530021.
Zhao
Y
Y
Lin
Q
Q
Xie
G
G
Yang
P
P
Yin
X
X
D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D037621:Artemisinins / Q000302:isolation & purification / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors* / Q000097:blood; D005260:Female; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D012717:Sesquiterpenes; D003577:Cytochrome P-450 Enzyme System; C031327:artemisinin; D013482:Superoxide Dismutase