Thrombomodulin Ala455Val dimorphism is not associated with pre-eclampsia in Australian and New Zealand women.
Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.
Borg
Anthony J
AJ
Department of Perinatal Medicine, The Royal Women's Hospital, Carlton, Vic., Australia.
Higgins
John R
JR
Brennecke
Shaun P
SP
Moses
Eric K
EK
D000483:Alleles; D001315:Australia; D001483:Base Sequence; D015331:Cohort Studies; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D009520:New Zealand; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D018180:Thrombomodulin / Q000737:chemistry / Q000235:genetics*
D018180:Thrombomodulin; D004247:DNA