Smaller frontal lobe white matter volumes in depressed adolescents.
BACKGROUND
Prior studies have demonstrated reduced frontal lobe volumes in depressed adolescents. In this study, frontal lobe gray and white matter volumes in adolescents with major depressive disorder were evaluated.


METHODS
Nineteen depressed and thirty-eight healthy comparison adolescents were recruited for a magnetic resonance imaging study. Images were segmented into gray matter, white matter, and cerebrospinal fluid. Morphometric measurements of the whole brain and frontal lobe region were completed.


RESULTS
Whole brain volumes were significantly smaller in depressed subjects compared with the healthy comparison subjects. Significantly smaller frontal white matter volumes and significantly larger frontal gray matter volumes were found in the depressed subjects, after controlling for age and whole brain volume.


CONCLUSIONS
These results are consistent with the hypothesis that a deficit in frontal volume exists during cortical development in adolescents with depression. Further studies are needed to assess whether volume differences resolve over time and the extent to which these differences influence response to treatment.
Steingard
Ronald J
RJ
Department of Psychiatry, University of Massachusetts Medical School (RJS, ML, DFC, THA), Worcester, Massachusetts, USA
Renshaw
Perry F
PF
Hennen
John
J
Lenox
Mara
M
Cintron
Christina Bonella
CB
Young
Ashley D
AD
Connor
Daniel F
DF
Au
Trang H
TH
Yurgelun-Todd
Deborah A
DA
D000293:Adolescent; D003866:Depressive Disorder / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012494:Sampling Studies