title: [High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer].
abstract: Between June 1998 and August 2000, five patients with germ cell tumor were treated with high-dose CEI: carboplatin (1,250 mg/m2), etoposide (1,500 mg/m2), and ifosfamide (7.5 g/m2), followed by peripheral blood stem cell transplantation (PBSCT) at Yokohama City University Hospital. All patients were classified into either poor risk group of International Germ Cell Consensus Classification or advanced extent of Indiana University stage, and received one cycle of high-dose CEI after 4-6 cycles of standard PEB (cisplatin, bleomycin, vinblastin) therapy. Three of the patients achieved complete response, one achieved partial response and one achieved no change after whole treatment. There were no fatal complications and no treatment-related deaths.
authors.affiliation: Department of Urology, Yokohama City University School of Medicine.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hasumi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kishida
authors.forename: Junichi
authors.initials: J
authors.lastname: Teranishi
authors.forename: Noboru
authors.initials: N
authors.lastname: Nakaigawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujinami
authors.forename: Ichirou
authors.initials: I
authors.lastname: Ikeda
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yao
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Takeda
authors.forename: Sumio
authors.initials: S
authors.lastname: Noguchi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D018237:Germinoma / Q000188:drug therapy / Q000628:therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D016179:Granulocyte Colony-Stimulating Factor; D014747:Vinblastine; D002945:Cisplatin