Protein Z influences the prothrombotic phenotype in Factor V Leiden patients.
Protein Z enhances the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). Thus, diminution of protein Z should induce prothrombotic tendency due to lowered cofactor activity for ZPI. In Factor V Leiden mice, prothrombotic tendency of severe diminution or lack of protein Z was demonstrated. We here present first studies in humans, indicating that diminution of protein Z in factor V Leiden patients aggravates thromboembolic risk.
Kemkes-Matthes
Bettina
B
Zentrum für Innere Medizin der Justus Liebig Universität Giessen, Klinikstrasse 36, D-35385 Giessen, Germany. Bettina.Kemkes-Mathes@innere.med.uni-giessen.de
Nees
Margareta
M
Kühnel
Gitta
G
Matzdorff
Axel
A
Matthes
Karl J
KJ
D000328:Adult; D017668:Age of Onset; D000368:Aged; D001798:Blood Proteins / Q000032:analysis / Q000502:physiology*; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D018709:Statistics, Nonparametric; D019851:Thrombophilia / Q000097:blood*; D020246:Venous Thrombosis / Q000097:blood
D001798:Blood Proteins; C095381:factor V Leiden; C026080:plasma protein Z; D005165:Factor V