title: A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.
abstract: The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
authors.affiliation: Department of Chemistry, New York University, New York, NY 10003, USA.
authors.forename: Ho-Sang
authors.initials: HS
authors.lastname: Moon
authors.forename: Eric M
authors.initials: EM
authors.lastname: Jacobson
authors.forename: Sonya M
authors.initials: SM
authors.lastname: Khersonsky
authors.forename: Michael R
authors.initials: MR
authors.lastname: Luzung
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Walsh
authors.forename: Wennan
authors.initials: W
authors.lastname: Xiong
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Puja B
authors.initials: PB
authors.lastname: Parikh
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Lam
authors.forename: Tae-Wook
authors.initials: TW
authors.lastname: Kang
authors.forename: Gustavo R
authors.initials: GR
authors.lastname: Rosania
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Schier
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D008870:Microtubules / Q000187:drug effects*; D011687:Purines / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015027:Zebrafish / Q000196:embryology*
chemical_list: D000970:Antineoplastic Agents; D011687:Purines; D014227:Triazines; C407365:myoseverin