title: Tumour thickness as a predictor of occult lymph node metastases in patients with stage I and II melanoma undergoing sentinel lymph node biopsy.
abstract: BACKGROUND
  Sentinel lymph node biopsy (SLNB) is a minimally invasive procedure used accurately to stage nodal basins at risk of occult metastases. There are no data as yet to show a survival benefit from SLNB and its use remains controversial. If Breslow thickness of the tumour correlates well with positive SLNB, it could be used to select patients for SLNB.
  
  
  METHODS
  A quantitative systematic review of published studies on SLNB in patients with melanoma available by September 2001 was performed.
  
  
  RESULTS
  Twelve studies containing 4218 patients with stage I and II melanoma were identified; 17.8 (95 per cent confidence interval 16.7 to 19.0) per cent of patients had nodal micrometastases detected by SLNB. The incidence of micrometastasis in sentinel nodes correlated directly with Breslow tumour thickness; it was 1.0 per cent for lesions of less than or equal to 0.75 mm, 8.3 per cent for 0.76-1.50 mm, 22.7 per cent for 1.51-4.0 mm and 35.5 per cent for more than 4.0 mm.
  
  
  CONCLUSIONS
  The Breslow thickness of primary melanoma predicts the presence of a sentinel node metastasis. The published data are not sufficient to demonstrate a correlation between other known prognostic indicators and a positive SLNB.
authors.affiliation: University of Oxford, Centre for Evidence-Based Medicine, Nuffield Department of Clinical Medicine and Department for Plastic and Reconstructive Surgery, The Oxford Radcliffe NHS Trust, Oxford, UK.
authors.forename: M B
authors.initials: MB
authors.lastname: Lens
authors.forename: M
authors.initials: M
authors.lastname: Dawes
authors.forename: J A
authors.initials: JA
authors.lastname: Newton-Bishop
authors.forename: T
authors.initials: T
authors.lastname: Goodacre
mesh_terms: D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008545:Melanoma / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D012878:Skin Neoplasms / Q000473:pathology*