title: Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic.
abstract: BACKGROUND
  Predicting transitions to psychosis is difficult. Neuropsychology might facilitate predictions.
  
  
  OBJECTIVE
  To report preliminary data on self-perceived and objectively measurable neurocognition in prodromal patients of the first German early recognition centre.
  
  
  METHODS
  Subjective neuropsychological disturbances were assessed in 51 patients with potentially prodromal symptoms of schizophrenia. Initial neurocognitive functioning was compared with matched normals and patients with schizophrenia.
  
  
  RESULTS
  Self-perceived deficits mostly concerned perception, cognition and stress reactivity. Five transitions happened during the 15-month follow-up. Recently emerging or intensifying deficits were to some extent predictive of transition. Persons at risk performed worse than controls on objectively measured verbal capacity, attention and memory functions.
  
  
  CONCLUSIONS
  Neuropsychological deficits, either self-perceived or objectively measured, characterise persons at risk for schizophrenia and may contribute to predicting transitions.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Cologne, Germany. hambrecht.martin@krankenhaus-elisabethenstift.de
authors.forename: Martin
authors.initials: M
authors.lastname: Hambrecht
authors.forename: Michael
authors.initials: M
authors.lastname: Lammertink
authors.forename: Joachim
authors.initials: J
authors.lastname: Klosterkötter
authors.forename: Eveline
authors.initials: E
authors.lastname: Matuschek
authors.forename: Ralf
authors.initials: R
authors.lastname: Pukrop
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012565:Schizophrenic Psychology; D012647:Self-Assessment