Cytotoxic activity of aminoderivatized cationic chitosan derivatives.
Chitosan derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. In this study, the cytotoxic activity of the chitosan derivatives was investigated and a relationship between structure and activity is suggested. The cationic chitosan derivatives elicited dose-dependent inhibitory effects on the proliferation of tumor cell lines.
Lee
Jung-Kul
JK
BioNgene Co., Ltd., 10-1, 1Ka Myungryun-Dong, Chongro-Ku, Seoul, South Korea.
Lim
Hyun-Soo
HS
Kim
Jung-Hoe
JH
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D002686:Chitin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D048271:Chitosan; D004983:Ethanolamines; D006801:Humans; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004983:Ethanolamines; D007202:Indicators and Reagents; D002686:Chitin; D048271:Chitosan; C007369:2-diethylaminoethanol