Synthesis of BF2 chelates of tetraarylazadipyrromethenes and evidence for their photodynamic therapeutic behaviour.
The synthesis, spectroscopic characteristics and in vitro cellular uptake properties of a new class of therapeutic window photosensitiser, namely the BF2 chelates of 3,5-diaryl-1H-pyrrol-2-yl-3,5-diarylpyrrol-2-ylidene amines (tetra-arylazadipyrromethenes), are described with the aim of developing a novel class of photodynamic therapeutic agents.
Killoran
John
J
Centre for Synthesis and Chemical Biology, Conway Institute, Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
Allen
Lorcan
L
Gallagher
John F
JF
Gallagher
William M
WM
O'Shea
Donal F
DF
D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010778:Photochemotherapy / Q000379:methods*; D013053:Spectrophotometry; D013997:Time Factors
D006575:Heterocyclic Compounds, 3-Ring