Tumor-mediated apoptosis of cancer-specific T lymphocytes--reversing the "kiss of death"?
Recent studies have provided evidence that some cancers can aberrantly express molecules capable of inducing apoptosis of tumor-reactive lymphocytes. Several other potential tumor escape mechanisms that can block the cytotoxic pathways activated by killer T cells have also been proposed.
Trapani
Joseph A
JA
Cancer Immunology Program, Peter MacCallum Cancer Institute, A' Beckett Street, 8006, Melbourne, Australia. j.trapani@pmci.unimelb.edu.au
D000818:Animals; D017209:Apoptosis; D003602:Cytotoxicity, Immunologic; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism; D019139:Tumor Escape