Behavior of uptake of moisture by drugs and excipients under accelerated conditions of temperature and humidity in the absence and the presence of light. 1. Pure anti-tuberculosis drugs and their combinations.
An investigation was carried out to determine the behavior of moisture gain by four anti-tuberculosis drugs, viz. rifampicin, isoniazid, pyrazinamide and ethambutol, when exposed in pure form and in combinations to accelerated conditions of 40 degrees C and 75% RH, in the absence and the presence of light. Weight gain was seen only in those samples that contained ethambutol, and this behavior was observed both in dark and lighted chambers. There was a decrease in moisture uptake with an increase in the number of drugs in the mixture. Another observation was a higher weight gain by the mixture of ethambutol and isoniazid in a dark chamber, than either pure ethambutol or drug combinations containing ethambutol. The most interesting finding was an overall acceleration of weight gain in the presence of light as compared with dark conditions, which is a hitherto unknown phenomenon.
Singh
Saranjit
S
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, 160 062, S.A.S. Nagar, India. ssingh@niper.ac.in
Bhutani
H
H
Mariappan
T T
TT
Kaur
Harpinder
H
Bajaj
M
M
Pakhale
S
S
D000327:Adsorption; D000995:Antitubercular Agents / Q000737:chemistry* / Q000528:radiation effects; D003624:Darkness; D004338:Drug Combinations; D004355:Drug Stability; D004977:Ethambutol / Q000737:chemistry / Q000528:radiation effects; D005079:Excipients / Q000737:chemistry* / Q000528:radiation effects; D007538:Isoniazid / Q000737:chemistry / Q000528:radiation effects; D008027:Light; D011718:Pyrazinamide / Q000737:chemistry / Q000528:radiation effects; D012293:Rifampin / Q000737:chemistry / Q000528:radiation effects; D013696:Temperature; D014867:Water / Q000737:chemistry*
D000995:Antitubercular Agents; D004338:Drug Combinations; D005079:Excipients; D014867:Water; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin