title: Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.
abstract: The structure-affinity relationships of two novel 2-substituted adenosine series containing a substituted pyrazole attached at the N-1 or C-4 position for the adenosine (ADO) A2A receptor are described. Compounds in the 2-(N-1-pyrazolyl) adenosine series IV provided the highest affinity for the ADO A2A receptor as compared to the 2-(C-4-pyrazolyl) series V. The main structural differences between the two series point to the N-1 nitrogen of series IV imparting more favorable binding interactions with the receptor than those of series V.
authors.affiliation: Department of Bioorganic Chemistry, CV Therapeutics, 3172 Porter Drive, Palo Alto, CA 94304, USA. jeff.zablocki@cut.com
authors.forename: Venkata P
authors.initials: VP
authors.lastname: Palle
authors.forename: Elfatih O
authors.initials: EO
authors.lastname: Elzein
authors.forename: Scott A
authors.initials: SA
authors.lastname: Gothe
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Li
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Gao
authors.forename: Stephanie
authors.initials: S
authors.lastname: Meyer
authors.forename: Brent
authors.initials: B
authors.lastname: Blackburn
authors.forename: Jeff A
authors.initials: JA
authors.lastname: Zablocki
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C471906:2-pyrazolyl adenosine; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D014665:Vasodilator Agents; D000241:Adenosine