Sustained release systems for ethinylestrogens.
The immunoreactive serum concentration of ethinylestradiol (EE) was measured by a specific radioimmunoassay after a single intramuscular administration of a combined preparation of Norethindrone (NET) and Mestranol (ME).  The mean peak serum value for the 6 women studied was 278.5 pm/m1/m2 of body surface area (BSA), and was reached 11.17 days after dosing, with a half-life of absorption (T1/2 abs) of 9.37 days.  In 5 out of 6 subjects EE was detectable in the circulaton for 21 days after injection.  The mean serum concentration time curve was calculated in 2720.67 pg/day/m1/m2.  The shape of the 1-21 day concentration-time curve shows a sustained release pattern, suitable for a long acting fertility regulation method.
Diaz-sanchez
V
V
Garza-flores
J
J
Rosales
M D
MD
Thomas
S J
SJ
D001695:Biology; D003267:Contraception; D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003278:Contraceptives, Oral, Hormonal; D004467:Economics; D004703:Endocrine System; D004997:Ethinyl Estradiol; D005069:Evaluation Studies as Topic; D005193:Family Planning Services; D006728:Hormones; D010827:Physiology; D012102:Reproductive Control Agents; D012106:Research; D013672:Technology
D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003278:Contraceptives, Oral, Hormonal; D006728:Hormones; D012102:Reproductive Control Agents; D004997:Ethinyl Estradiol
Biology; Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Estrogen; Contraceptive Agents, Female; Economic Factors; Endocrine System; Ethinyl Estradiol; Evaluation; Family Planning; Hormones; Physiology; Reproductive Control Agents; Research And Development; Research Methodology; Technology