title: High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay.
abstract: We describe a high frequency of the MIC null haplotype, HLA-B48-MICA-del-MICB*0107 N, in the Angaite Amerindian community in Paraguay. Of the 16 unrelated subjects, 9 (56.5%) had this haplotype. The structural analyses revealed this haplotype was similar to the previously reported Asian haplotype in that they had a large-scale deletion including the entire MICA gene and linked to MICB*0107 N and HLA-B*48. The novel recombination haplotype between this MIC null haplotype and HLA-B15, HLA-B15-MICA-del-MICB*0107 N, was also found in this community.
authors.affiliation: Department of Medical Zoology, Saitama Medical School, Moroyama, Japan.
authors.forename: Kayano
authors.initials: K
authors.lastname: Aida
authors.forename: Graciela
authors.initials: G
authors.lastname: Russomando
authors.forename: Mihoko
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Norma
authors.initials: N
authors.lastname: Candia
authors.forename: Leticia
authors.initials: L
authors.lastname: Franco
authors.forename: Maria
authors.initials: M
authors.lastname: Almiron
authors.forename: Ratawan
authors.initials: R
authors.lastname: Ubalee
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirayama
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D015235:HLA-B Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008297:Male; D010239:Paraguay; D010375:Pedigree; D011995:Recombination, Genetic; D017384:Sequence Deletion
chemical_list: D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen; D004247:DNA