The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.
The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.
Paulsen
Ian T
IT
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ipaulsen@tigr.org
Seshadri
Rekha
R
Nelson
Karen E
KE
Eisen
Jonathan A
JA
Heidelberg
John F
JF
Read
Timothy D
TD
Dodson
Robert J
RJ
Umayam
Lowell
L
Brinkac
Lauren M
LM
Beanan
Maureen J
MJ
Daugherty
Sean C
SC
Deboy
Robert T
RT
Durkin
A Scott
AS
Kolonay
James F
JF
Madupu
Ramana
R
Nelson
William C
WC
Ayodeji
Bola
B
Kraul
Margaret
M
Shetty
Jyoti
J
Malek
Joel
J
Van Aken
Susan E
SE
Riedmuller
Steven
S
Tettelin
Herve
H
Gill
Steven R
SR
White
Owen
O
Salzberg
Steven L
SL
Hoover
David L
DL
Lindler
Luther E
LE
Halling
Shirley M
SM
Boyle
Stephen M
SM
Fraser
Claire M
CM
D020561:Alphaproteobacteria / Q000235:genetics; D002002:Brucella / Q000235:genetics* / Q000472:pathogenicity; D017347:Brucella melitensis / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000648:ultrastructure; D004251:DNA Transposable Elements; D016680:Genome, Bacterial; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012231:Rhizobium / Q000235:genetics
D004251:DNA Transposable Elements