title: Male contraception: the effect of d-norgestrel and testosterone enanthate on spermatogenesis--ultrastructural characteristics.
abstract: Electron microscopy was performed on testicular biopsies from men during a contraceptive regimen with d-norgestrel and testosterone enanthate.  There was a considerable reduction of spermatogenesis, the seminiferous tubules being lined with a low epithelium of early spermatogenetic cells and only few late stages and spermatozoa.  At the ultrastructural level, no qualitative changes could be observed in any of the tubular cells, a fact that seems to be of significance in contraception where any possible change should be entirely reversible.
authors.forename: H
authors.initials: H
authors.lastname: Pedersen
authors.forename: M
authors.initials: M
authors.lastname: Foegh
mesh_terms: D000728:Androgens; D001695:Biology; D019411:Clinical Laboratory Techniques; D003267:Contraception; D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003933:Diagnosis; D004703:Endocrine System; D005069:Evaluation Studies as Topic; D005193:Family Planning Services; D005640:Follicle Stimulating Hormone; D006653:Histology; D006728:Hormones; D016912:Levonorgestrel; D007986:Luteinizing Hormone; D010827:Physiology; D012098:Reproduction; D013076:Sperm Count; D013091:Spermatogenesis; D013739:Testosterone
chemical_list: D000728:Androgens; D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D006728:Hormones; D013739:Testosterone; D016912:Levonorgestrel; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Androgens; Biology; Contraception; Contraception Research; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents--administraction and dosage; Endocrine System; Examinations And Diagnoses; Family Planning; Follicle Stimulating Hormone; Histology; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Levonorgestrel--administraction and dosage; Luteinizing Hormone; Male Contraception; Physiology; Reproduction; Sperm Count--analysis; Spermatogenesis; Testosterone--administraction and dosage; Use-effectiveness