A comparison of the efficacy of gemeprost vaginal pessaries and extra-amniotic prostaglandin E2 gel in the induction of middle trimester abortion.
In an open random allocation trial of 50 patients, 25 had abortion induced vaginally with gemeprost  (16.16-dimethyl-trans-delta squared- prostaglandin E1 methyl ester; PGE) 1 mg pessaries inserted into the posterior fornix.  The remainder received 7.5 mg PGE2 in a gel inserted into the extraamniotic space.  Following the administration of 2 doses of PGE2 gel, abortion was achieved in 100% of the cases within 24 hours, whereas the group treated with a maximum of 3 gemeprost pessaries administered at 3-hour intervals only achieved abortion within 24 hours in 76% of the cases.  3 doses of gemeprost pessaries are the cost equivalent of 2 doses of PGE2 gel.
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Bourne
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D000028:Abortion, Induced; D001695:Biology; D055598:Chemical Phenomena; D002621:Chemistry; D003267:Contraception; D003268:Contraception Behavior; D003362:Cost-Benefit Analysis; D003710:Demography; D019049:Developed Countries; D004703:Endocrine System; D004739:England; D005060:Europe; D005069:Evaluation Studies as Topic; D005193:Family Planning Services; D006801:Humans; D010342:Patient Acceptance of Health Care; D010827:Physiology; D011153:Population; D011157:Population Dynamics; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011453:Prostaglandins; D012098:Reproduction; D012106:Research; D013997:Time Factors; D006113:United Kingdom
D011453:Prostaglandins
Abortion, Drug Induced; Abortion, Induced; Biology; Comparative Studies; Contraception; Contraceptive Usage; Cost Benefit Analysis; Demographic Factors; Developed Countries; Endocrine System; England; Europe; Evaluation; Family Planning; Fertility Control, Postconception; Ingredients And Chemicals; Method Acceptability; Northern Europe; Physiology; Population; Population Dynamics; Pregnancy; Pregnancy, First Trimester; Pregnancy, Second Trimester; Prostaglandins--administraction and dosage; Quantitative Evaluation; Reproduction; Research Methodology; Studies; Time Factors; United Kingdom