title: Prospective validation of the Glasgow Meningococcal Septicaemia Prognostic Score. Comparison with other scoring methods.
abstract: A prospective observational study was done to derive performance characteristics for the Glasgow Meningococcal Septicaemia Prognostic Score (GMSPS) and compare it with nine other severity scores (Stokland, Stiehm and Damrosch, Ansari, Niklasson, Leclerc, Kahn and Blum, Lewis, Istanbul and Bjark) and laboratory markers of disease severity. In the paediatric departments of six hospitals in Merseyside, UK, 278 children with confirmed or probable meningococcal disease were admitted between November 1988 and August 1990 ( n=152) and between September 1992 and April 1994 ( n=126); 26 of whom died. GMSPS was recorded on admission and again if there was clinical deterioration. Laboratory markers of disease severity (including endotoxin and cytokine levels) were measured on admission. The nine other scores were recorded on the first cohort. "Maximum" GMSPS (before referral to the paediatric intensive care unit) was achieved within 12 h of arrival in 97% of children. A GMSPS > or =8 had sensitivity 100%, specificity 75% and positive predictive value for death of 29%, GMSPS > or =10 had 100%, 88% and 46% respectively. All 26 who died scored >10, before referral to the paediatric intensive care unit. GMSPSs calculated by other medical staff had similar characteristics to those calculated by research fellows. All scores correlated significantly with white cell count, coagulopathy, endotoxin and cytokine levels. However, the predominantly clinical scores were the most robust. GMSPS had amongst the best performance characteristics of all scores and was more sensitive than laboratory markers.
  
  
  CONCLUSIONS
  the Glasgow Meningococcal Septicaemia Prognostic Score is an easily performed, repeatable, clinical score that can rapidly identify children with fulminant meningococcal disease. When performed prospectively, a score > or =8 had a positive predictive value for death of 29%. This score can identify those children who should be offered intensive care and can select those who may benefit from novel therapies.
authors.affiliation: Institute of Child Health, University of Liverpool, Liverpool, UK. Riordaa@heartsol.wmids.nhs.uk
authors.forename: F Andrew I
authors.initials: FA
authors.lastname: Riordan
authors.forename: Omnia
authors.initials: O
authors.lastname: Marzouk
authors.forename: Alistair P J
authors.initials: AP
authors.lastname: Thomson
authors.forename: John A
authors.initials: JA
authors.lastname: Sills
authors.forename: C Anthony
authors.initials: CA
authors.lastname: Hart
mesh_terms: D015415:Biomarkers / Q000097:blood; D002669:Child Welfare; D002675:Child, Preschool; D015331:Cohort Studies; D004731:Endotoxins / Q000097:blood; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008585:Meningitis, Meningococcal / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D009345:Neisseria meningitidis; D010343:Patient Admission; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012606:Scotland; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000175:diagnosis* / Q000401:mortality; D012720:Severity of Illness Index; D013223:Statistics as Topic; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D004731:Endotoxins; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha