Alcoholic extract of 'Bacopa monniera' reduces the in vitro effects of morphine withdrawal in guinea-pig ileum.
The effect of the alcoholic extract of the whole plant of Bacopa monniera (Scrophulariaceae) on morphine withdrawal was evaluated in vitro in guinea-pig ileum. After a 4 min in vitro exposure to morphine, addition of naloxone induced a strong contraction. Addition of various concentrations of the alcoholic extract of B. monniera (100-1000 microg/ml) 15 min before exposure to morphine reduced the naloxone-induced contraction in a dose-dependent manner. The results suggest that B. monniera extract may be useful in reducing the withdrawal symptoms induced by morphine.
Sumathi
Thangarajan
T
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.
Nayeem
Mohamed
M
Balakrishna
Kedike
K
Veluchamy
Gopalsamy
G
Devaraj
Sivasithamparam Niranjali
SN
D000818:Animals; D034681:Bacopa; D000431:Ethanol / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018514:Plant Structures; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D010936:Plant Extracts; D000431:Ethanol; D009020:Morphine