title: Diagnostic implications of circulating oxidized low density lipoprotein levels as a biochemical risk marker of coronary artery disease.
abstract: OBJECTIVE
  To examine the diagnostic performance of circulating oxidized low density lipoprotein levels as a biochemical risk marker of coronary heart disease.
  
  
  METHODS
  361 patients with coronary artery disease and 710 healthy volunteers as normal controls were examined. Receiver-operating characteristics curve analysis in addition to statistical analysis (univariate, multivariate) were done to determine the usefulness of the assay.
  
  
  RESULTS
  Patients with coronary artery disease showed significantly elevated circulating oxidized low density lipoprotein levels. Males less than 70 years of age showed a significant association between oxidized low density lipoprotein levels and coronary artery disease. Receiver-operating characteristics curve analysis showed superior performance (e.g., sensitivity, specificity) of oxidized low density lipoprotein as a diagnostic marker of coronary artery disease as compared against other lipid markers (total cholesterol, triglyceride, high density lipoprotein, lipoprotein (a), and total cholesterol to high density lipoprotein ratio) with optimal performance in younger males.
  
  
  CONCLUSIONS
  Oxidized low density lipoprotein levels may be a promising biochemical risk marker of atherosclerotic disease, especially in young males.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kohno
authors.forename: Akira
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Shunichi
authors.initials: S
authors.lastname: Toshima
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Amaki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Amaki
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Akira
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Shunichi
authors.initials: S
authors.lastname: Toshima
authors.forename: Masa-hiko
authors.initials: MH
authors.lastname: Kurabayashi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shimada
authors.forename: Haruo
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tamio
authors.initials: T
authors.lastname: Teramoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Nishiyama
authors.forename: Hakuo
authors.initials: H
authors.lastname: Takahashi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Michishita
authors.forename: Zinpei
authors.initials: Z
authors.lastname: Sugano
authors.forename: Keiko
authors.initials: K
authors.lastname: Konoshi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012044:Regression Analysis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein