title: c-erbB2 over-expression in endometrial hyperplasia induced by estrogens.
abstract: OBJECTIVE
  To determine whether the presence of c-erbB2 expression in both spontaneous and estrogen-induced hyperplasia can affect the number of Ki-67-positive cells.
  
  
  METHODS
  Thirty-two postmenopausal women with endometrial hyperplasia occurring spontaneously or after using unopposed estrogens were studied. The number of cells undergoing mitosis was estimated by immunohistochemical detection of the Ki-67 antigen and compared with the presence or absence of c-erbB2 over-expression.
  
  
  RESULTS
  The percentage of cell nuclei showing positivity for Ki-67 was significantly higher in cases of endometrial hyperplasia that displayed c-erbB2 over-expression when compared to negative cases.
  
  
  CONCLUSIONS
  The presence of c-erbB2 over-expression in endometrial hyperplasia is associated with a higher number of cells being positive for the Ki-67 proliferation marker.
authors.affiliation: CEPARH, Rua Caetano Moura, 35 Salvador, 40210-341, Bahia, Brazil. ceparh@uol.com.br
authors.forename: Hugo
authors.initials: H
authors.lastname: Maia
authors.forename: Amélia
authors.initials: A
authors.lastname: Maltez
authors.forename: Célia
authors.initials: C
authors.lastname: Athayde
authors.forename: Elsimar M
authors.initials: EM
authors.lastname: Coutinho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004714:Endometrial Hyperplasia / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D004967:Estrogens; D012739:Gonadal Steroid Hormones; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D013739:Testosterone