title: The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.
abstract: The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.
authors.affiliation: The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ipaulsen@tigr.org
authors.forename: Ian T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: Rekha
authors.initials: R
authors.lastname: Seshadri
authors.forename: Karen E
authors.initials: KE
authors.lastname: Nelson
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Eisen
authors.forename: John F
authors.initials: JF
authors.lastname: Heidelberg
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Read
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Dodson
authors.forename: Lowell
authors.initials: L
authors.lastname: Umayam
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Brinkac
authors.forename: Maureen J
authors.initials: MJ
authors.lastname: Beanan
authors.forename: Sean C
authors.initials: SC
authors.lastname: Daugherty
authors.forename: Robert T
authors.initials: RT
authors.lastname: Deboy
authors.forename: A Scott
authors.initials: AS
authors.lastname: Durkin
authors.forename: James F
authors.initials: JF
authors.lastname: Kolonay
authors.forename: Ramana
authors.initials: R
authors.lastname: Madupu
authors.forename: William C
authors.initials: WC
authors.lastname: Nelson
authors.forename: Bola
authors.initials: B
authors.lastname: Ayodeji
authors.forename: Margaret
authors.initials: M
authors.lastname: Kraul
authors.forename: Jyoti
authors.initials: J
authors.lastname: Shetty
authors.forename: Joel
authors.initials: J
authors.lastname: Malek
authors.forename: Susan E
authors.initials: SE
authors.lastname: Van Aken
authors.forename: Steven
authors.initials: S
authors.lastname: Riedmuller
authors.forename: Herve
authors.initials: H
authors.lastname: Tettelin
authors.forename: Steven R
authors.initials: SR
authors.lastname: Gill
authors.forename: Owen
authors.initials: O
authors.lastname: White
authors.forename: Steven L
authors.initials: SL
authors.lastname: Salzberg
authors.forename: David L
authors.initials: DL
authors.lastname: Hoover
authors.forename: Luther E
authors.initials: LE
authors.lastname: Lindler
authors.forename: Shirley M
authors.initials: SM
authors.lastname: Halling
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Boyle
authors.forename: Claire M
authors.initials: CM
authors.lastname: Fraser
mesh_terms: D020561:Alphaproteobacteria / Q000235:genetics; D002002:Brucella / Q000235:genetics* / Q000472:pathogenicity; D017347:Brucella melitensis / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000648:ultrastructure; D004251:DNA Transposable Elements; D016680:Genome, Bacterial; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012231:Rhizobium / Q000235:genetics
chemical_list: D004251:DNA Transposable Elements