title: Modular NRPSs are monomeric.
abstract: NRPSs, PKSs, and hybrid NRPS/PKSs are modular proteins with similar assembly-line organizations. Although PKSs function as dimers, new data demonstrate that functional NRPSs are monomeric. This discovery has significant implications for engineering artificial assemblies for the production of novel biotherapeutics.
mesh_terms: D001419:Bacteria; D020134:Catalytic Domain; D005658:Fungi; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism; D010453:Peptide Synthases / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D009097:Multienzyme Complexes; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase