[Microvascular density in carcinoma of the tongue].
BACKGROUND
Assessment of microvascular density in squamous cell carcinoma of the oral tongue (primary lesion and metastasis).


METHODS
Immunohistochemical analysis by anti CD-34 of neoangiogenesis density and its relation with clinical and histological data concerning the prognosis. After optic microscopy amplification, the relation between microvascular density, clinico-histological data and prognosis, was established.


RESULTS
The microvascular density presented 15.4 vessels/field (5.5 to 25.3) in primary tumors and 16.4 vessels/field (12 to 32.2) in lymph node metastases. It was observed an inverse relation between microvascular density in primary lesions and their lymph node metastasis (r= -0.68 and p=0,04).


CONCLUSIONS
No evidence was detected between microvascular density, histological features and prognosis. There is an inverse relation between microvascular density in primary tumor and in lymphonode metastasis, suggesting a regional or systemic control of angiogenesis in squamous cell carcinoma of the oral tongue.
D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000098:blood supply* / Q000473:pathology
Densidade microvascular no carcinoma de língua.