title: Continuous cerebral autoregulation monitoring by cross-correlation analysis: evaluation in healthy volunteers.
abstract: OBJECTIVE
  In a former study, we applied cross-correlation (CC) analysis to recordings of arterial blood pressure (BP), intracranial pressure (ICP), and intracranial blood flow velocity (FV). A lack of significant time delay and a positive correlation coefficient of slow oscillations between these parameters was interpreted as indicative of impaired cerebral autoregulation, whereas a significant time delay and a negative correlation was regarded as preserved autoregulation. To test this hypothesis, cross-correlation was applied on recordings of BP and FV (CC [BP --> FV]) in healthy volunteers with a presumably preserved cerebral autoregulation.
  
  
  METHODS
  Study of a diagnostic test.
  
  
  METHODS
  A total of 17 healthy volunteers.
  
  
  RESULTS
  BP was recorded by using a tonometric device, and bilateral FV in the middle cerebral arteries (MCA) was measured by transcranial Doppler sonography. Signals were sampled at a resting horizontal position for 29 mins. Cluster analysis showed a mean +/- sd time delay for CC [BP --> FV(MCA right)] of 6.45 +/- 2.1 secs, and for CC [BP --> FV(MCA left) ] of 6.09 +/- 1.8 secs. The mean correlation coefficient was -.33 +/-.17 for the left and -.36 +/-.09 for the right side. In about 30%, differing results with a correlation coefficient between -.2 and.2 and a time delay near zero were found. Cross-correlation between left and right FV showed a mean time delay of 0.09 +/- 0.18 secs, with a mean correlation coefficient of.82 +/-.16. CONCLUSION Spontaneous slow oscillations of BP and FV were detected, and cross-correlation analysis showed a negative correlation and a positive time delay in about 70% of the examinations. These findings corroborate the hypothesis that CC [BP --> FV] might be able to assess the status of cerebral autoregulation continuously. The observed time delay between BP and FV oscillations is in good agreement with former studies on the dynamic properties of cerebral autoregulation.
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging*; D016000:Cluster Analysis; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D014463:Ultrasonography