title: Mapping T2 relaxation time in the pediatric knee: feasibility with a clinical 1.5-T MR imaging system.
abstract: OBJECTIVE
  To determine the feasibility of mapping the spatial variation of cartilage T2 relaxation time in vivo in the pediatric knee with a 1.5-T clinical magnetic resonance (MR) imaging system and the manufacturer's body gradient coil.
  
  
  METHODS
  Twenty-five children and adolescents (age range, 5-17 years; mean age, 11.8 years) underwent a multisection-multiecho MR sequence for T2 relaxation time mapping. Quantitative transverse T2 maps of the patellar cartilage were calculated for 15 of the subjects. Sagittal T2 maps were calculated for the remaining 10 subjects. T2 profiles were generated for the patellar and distal femoral weight- and non-weight-bearing unossified epiphyseal and articular hyaline cartilage and for the distal femoral and proximal tibial physes. The Mann-Whitney U test was used to test for differences between paired profiles.
  
  
  RESULTS
  Femoral non-weight-bearing unossified epiphyseal and articular cartilage showed spatial variation similar to that of weight-bearing unossified epiphyseal and articular cartilage, but with increased T2 values (P <.001). T2 spatial variations of the distal femoral and proximal tibial physes were similar to those of epiphyseal and articular cartilage but had a different pattern and increased magnitude (P <.001). The highest T2 values were measured in the distal femoral physis.
  
  
  CONCLUSIONS
  T2 spatial variation of patellar hyaline cartilage in children is similar to that of patellar articular cartilage in adults. Mapping of spatial variation of T2 relaxation time of cartilage in the pediatric knee in vivo is feasible with a clinical 1.5-T MR imaging system and a body gradient coil.
mesh_terms: D000293:Adolescent; D002358:Cartilage, Articular / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004838:Epiphyses / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D005269:Femur / Q000473:pathology; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis / Q000473:pathology; D007718:Knee Injuries / Q000175:diagnosis / Q000473:pathology; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D010329:Patella / Q000473:pathology; D013977:Tibia / Q000473:pathology