Clonal expansion of limited T cell clonotypes in affected muscle from a patient with post-transplant polymyositis.
Critical roles of T cells in idiopathic polymyositis have been suggested, but, those in polymyositis occurring as GVHD after BMT are poorly understood. We thus investigated T cell clonality in a patient with post- transplant polymyositis. As a result, T cell receptor beta chains used various BV families in peripheral blood, but only one BV family (BV7) in affected muscle. Importantly, T cells proliferated oligoclonally both in the peripheral blood and the muscle, however, the expanded clonotypes were completely different. Taken together, T cells expanded in the muscle, possibly stimulated by limited kinds of antigens, may drive myositis.
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002455:Cell Division; D002999:Clone Cells / Q000166:cytology; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D017285:Polymyositis / Q000209:etiology / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology*; D014184:Transplantation, Homologous
D011948:Receptors, Antigen, T-Cell