title: Technical note: the comparison of hypointense lesions from 'pseudo-T1' and T1-weighted images in secondary progressive multiple sclerosis.
abstract: There is a large historical database of dual-echo conventional spin-echo (CSE) magnetic resonance images in multiple sderosis (MS). If new analysis techniques can be developed then this database could provide valuable information. We have investigated a technique in which the late echo of a dual-echo data set is subtracted from the corresponding early echoyielding images, which appear qualitatively similar to T1-weighted images. This study investigated whether the hypointense lesions on the 'pseudo-T1' images (created as described above) were related to hypointense lesions on conventional T1-weighted images. The hypointense lesion areas were measured by a blinded observer using a computer-assisted contouring technique applied to pseudo-T1 and T1-weighted CSE images obtained from 17 patients with secondary progressive MS (SPMS). The mean hypointense lesion area from T1-weighted images was 2218 +/- 2072 mm2, compared to 1426 +/- 1353 mm2 from pseudo-T1 images (p = 0.008). There was, however, a strong correlation between the values obtained from the two sets of images (r = 0.93, p < 0.001). The strong correlation between the values obtained from the two sets of images suggests that pseudo-T1 images may be useful to investigate a subgroup of more destructive lesions in MS from historical databases and in future prospective studies when imaging time is limited.
mesh_terms: D001921:Brain / Q000473:pathology; D017352:Echo-Planar Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis*