title: Acute ethanol administration produces specific patterns of localization of Fos-immunoreactivity in the cerebellum and inferior olive of two inbred strains of mice.
abstract: Genes play an important role in behavioral responses to ethanol. We examined the response of neurons within the inferior olivary complex (IO) and cerebellum of C57Bl6/J and C3H/HeJ mice to acute ethanol, using immunodetection of Fos (Fos-IR) protein as a marker of neuronal activation. The results demonstrate specific but different patterns of Fos-IR within the IO and cerebellum, especially lobule IX, in each strain. The Fos-IR banding pattern seen in the granule cells of lobule IX is aligned with a previously described banding pattern of Purkinje cells that constitutively expressed heat-shock protein-25 (HSP-25).
mesh_terms: D000818:Animals; D000906:Antibodies; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002531:Cerebellum / Q000737:chemistry / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009847:Olivary Nucleus / Q000737:chemistry / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis* / Q000276:immunology
chemical_list: D000906:Antibodies; D002492:Central Nervous System Depressants; D016760:Proto-Oncogene Proteins c-fos; D000431:Ethanol