Emerging therapies for hepatocellular carcinoma: opportunities for radiologists.
Emerging molecular therapies offer an exciting new challenge to interventional radiologists, who are expected to play an essential role in the targeted delivery of many of these novel drug- and cell-based therapies. Specifically for the treatment of liver tumors, not only are several novel therapies being developed that will require direct intratumoral delivery, but drugs are also being produced to further enhance local delivery by increasing tumor permeability. Some therapies are being developed to inhibit efflux of drugs out of tumors and others to recruit immune cells into or around tumors. In this review, the authors describe the basic science behind these emerging technologies to provide interventional radiologists with a comprehensive background into the types of therapies they will be delivering.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D015641:Radiography, Interventional / Q000639:trends
D000970:Antineoplastic Agents