The spindle checkpoint: structural insights into dynamic signalling.
Chromosome segregation is a complex and astonishingly accurate process whose inner working is beginning to be understood at the molecular level. The spindle checkpoint plays a key role in ensuring the fidelity of this process. It monitors the interactions between chromosomes and microtubules, and delays mitotic progression to allow extra time to correct defects. Here, we review and integrate findings on the dynamics of checkpoint proteins at kinetochores with structural information about signalling complexes.
D000595:Amino Acid Sequence; D000818:Animals; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D002352:Carrier Proteins; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000502:physiology; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D006801:Humans; D018386:Kinetochores / Q000502:physiology*; D064246:Mad2 Proteins; D008938:Mitosis; D008954:Models, Biological; D008958:Models, Molecular; D009687:Nuclear Proteins; D011506:Proteins / Q000502:physiology; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000502:physiology*
C577495:CDC20 protein, S cerevisiae; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; C577695:MAD2 protein, S cerevisiae; C577697:MAD2L1 protein, human; D064246:Mad2 Proteins; D009687:Nuclear Proteins; D011506:Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; C577488:CDC20 protein, human