[Essential to discover hereditary colorectal and endometrial cancer. Mutations in "HNPCC individuals" can cause several different tumors].
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being for colorectal cancer and endometrial cancer. Hereditary mutations in one of several mismatch-repair (MMR) genes cause the syndrome, and 39 such mutations, involving the genes MLH1, MSH2 and MSH6, have been been characterized in Sweden. Screening programs for HNPCC have been shown to be cost-effective and to prevent cancer. Identification of HNPCC individuals thus allows prevention of additional tumors in the patient as well as in the family.
D020137:Base Pair Mismatch; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D003362:Cost-Benefit Analysis; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D005387:Finland; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000191:economics; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D013548:Sweden
Viktigt att upptäcka ärftliga fall av kolorektal- och endometriecancer. Mutationer hos "HNPCC-individer" kan orsaka flera tumörsjukdomar.