Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model.
We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P<0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.
D000375:Aging / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D000068438:Brimonidine Tartrate; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D005901:Glaucoma / Q000188:drug therapy*; D008559:Memantine / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D011810:Quinoxalines / Q000494:pharmacology; D012165:Retinal Ganglion Cells / Q000187:drug effects*; D013999:Timolol / Q000494:pharmacology
D000959:Antihypertensive Agents; D011810:Quinoxalines; D000068438:Brimonidine Tartrate; D013999:Timolol; D008559:Memantine