Emerging role of botulinum toxin in the treatment of neurogenic and non-neurogenic voiding dysfunction.
Botulinum toxin (BTX) is the most lethal naturally occurring toxin known to mankind. Why, then, would an urologist want to use this agent to poison the bladder or urethral sphincter? This article reviews the mechanisms underlying the effects of BTX treatment, summarizes the current usage of this agent within the urologic community, and provides perspectives on future targets of this therapy.
D018726:Anti-Dyskinesia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000494:pharmacology / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D009475:Neurons, Afferent / Q000187:drug effects; D014521:Urethra / Q000187:drug effects / Q000294:innervation; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*
D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins