title: Bioastronautics: optimizing human performance through research and medical innovations.
abstract: A strategic use of resources is essential to achieving long-duration space travel and understanding the human physiological changes in space, including the roles of food and nutrition in space. To effectively address the challenges of space flight, the Bioastronautics Initiative, undertaken in 2001, expands extramural collaboration and leverages unique capabilities of the scientific community and the federal government, all the while applying this integrated knowledge to Earth-based problems. Integral to the National Aeronautics and Space Administration's missions in space is the reduction of risk of medical complications, particularly during missions of long duration. Cumulative medical experience and research provide the ability to develop evidence-based medicine for prevention, countermeasures, and treatment modalities for space flight. The early approach applied terrestrial clinical judgment to predict medical problems in space. Space medicine has evolved to an evidence-based approach with the use of biomedical data gathered and lessons learned from previous space flight missions to systematically aid in decision making. This approach led, for example, to the determination of preliminary nutritional requirements for space flight, and it aids in the development of nutrition itself as a countermeasure to support nutritional mitigation of adaptation to space.
mesh_terms: D000222:Adaptation, Physiological; D000337:Aerospace Medicine; D018480:Astronauts; D019317:Evidence-Based Medicine; D005544:Forecasting; D006801:Humans; D009751:Nutritional Requirements; D012106:Research; D012307:Risk Factors; D013026:Space Flight; D014893:Weightlessness; D018544:Weightlessness Countermeasures