E2F1 pathways to apoptosis.
The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation and their activity is often deregulated in human tumors. Recent studies demonstrate that E2F1 can induce both proliferation and apoptosis. E2F1-induced apoptosis occurs via multiple pathways, some of which induce stabilization and activation of the tumor suppressor p53. The pro-apoptotic activity of E2F1 suggests that its deregulation constitutes an oncogenic stress that may target pre-malignant cells to undergo apoptosis, thus preventing tumor development.
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53