Cardioactive diterpenes from the roots of Salvia eriophora.
From the roots of Salvia eriophora (Lamiaceae), a new compound, 4,14-dihydroxysaprorthoquinone, was isolated in addition to ten known diterpenoids. The structure of the new compound was established by spectroscopic analysis. The crude extract of the plant and the isolated diterpenoids were tested for their cardiovascular activities using Wistar Albino rats. Activity was demonstrated in the crude extract and in 4,14-dihydroxysaprorthoquinone, aethiopinone, ferruginol, 4,12-dihydroxysapriparaquinone, and 6,7-dehydroroyleanone.
D045784:Abietanes; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification*; D051381:Rats; D017208:Rats, Wistar; D027544:Salvia
C469371:4,12-dihydroxysaprorthoquinone; C469369:4,14-dihydroxysaprorthoquinone; D045784:Abietanes; D004224:Diterpenes; D009285:Naphthoquinones; D010936:Plant Extracts; D011809:Quinones; C431074:ferruginol; C043551:6,7-dehydroroyleanone; C101972:aethiopinone; C045490:horminone