title: The pathogenesis of hepatitis C virus is influenced by cytomegalovirus.
abstract: We investigated the effect of beta-herpesviruses on allograft failure and mortality, hepatitis C virus (HCV) replication, and liver histologic characteristics among 92 HCV-infected liver transplant recipients. Reactivation of cytomegalovirus (CMV) but not of human herpesvirus 6 (HHV-6) was independently associated with allograft failure and mortality (risk ratio, 3.71; 95% confidence interval, 1.64-8.39); allograft failure and mortality was observed in 48% of patients with CMV disease, 35% of patients with subclinical CMV infection, and 17% of patients without CMV infection (P=.0275). CMV reactivation was highly predictive of mortality (P<.001), regardless of whether it remained subclinical or evolved into CMV disease. Patients with CMV disease had a higher fibrosis stage (P=.05) and had a trend toward a higher hepatitis activity index (P=.10) and HCV load (P=.10) at 16 weeks after liver transplantation. The pathogenesis of HCV is influenced by its interaction with CMV but not with HHV-6.
mesh_terms: D000328:Adult; D000368:Aged; D003587:Cytomegalovirus / Q000502:physiology*; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014762:Viral Interference; D014779:Virus Replication