Immunity-related genes and gene families in Anopheles gambiae.
We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster. Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.
D017398:Alternative Splicing; D000818:Animals; D000852:Anopheles / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology / Q000469:parasitology; D017209:Apoptosis; D001419:Bacteria / Q000276:immunology; D004156:Catechol Oxidase / Q000378:metabolism; D019295:Computational Biology; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D004792:Enzyme Precursors / Q000378:metabolism; D005786:Gene Expression Regulation; D017344:Genes, Insect; D016678:Genome; D007113:Immunity, Innate; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D010455:Peptides / Q000378:metabolism; D010802:Phylogeny; D010961:Plasmodium / Q000276:immunology / Q000502:physiology; D017434:Protein Structure, Tertiary; D012641:Selection, Genetic; D012697:Serine Endopeptidases / Q000378:metabolism; D015843:Serpins / Q000378:metabolism; D015398:Signal Transduction
D029721:Drosophila Proteins; D004792:Enzyme Precursors; D019476:Insect Proteins; D010455:Peptides; D015843:Serpins; C038451:pro-phenoloxidase; D004156:Catechol Oxidase; D012697:Serine Endopeptidases