Defining the outcome measures for out-of-hospital trials in acute pulmonary edema.
OBJECTIVE
Comparing studies of the effectiveness of out-of-hospital interventions in acute pulmonary edema (APE) is difficult due to the diversity of outcome measures used in the literature. The objective of this study was to define a set of clinically relevant outcome measures for future out-of-hospital trials in APE.


METHODS
A Medline search and hand-search of bibliographies was undertaken to develop a list of APE outcome measures. A survey was mailed to a sample of 227 Canadian emergency physicians using the Dillman methodology, requesting that respondents select clinically relevant outcome measures from this list and rank them by importance. A selection frequency of >or=70% and a median ranking score were used to determine relevant outcome measures.


RESULTS
The Medline and bibliography search identified 21 APE outcome measures. The survey response rate was 71%. Outcome measures selected most frequently were heart rate, respiratory rate, respiratory distress scale, subjective dyspnea scale, out-of-hospital intubation, emergency department (ED) intubation, survival to discharge, and out-of-hospital mortality. The median ranking score identified a similar set of measures: heart rate, respiratory rate, respiratory distress scale, subjective dyspnea scale, out-of-hospital intubation rate, and ED intubation rate. There was no significant difference in outcome selection between physicians who worked in communities with and without advanced out-of-hospital care.


CONCLUSIONS
Clinically relevant out-of-hospital APE outcome measures were identified and endorsed by a representative survey of Canadian emergency physicians. Clinicians appear to favor short-term and non-mortality outcomes for out-of-hospital interventions. The use of this set of APE outcome measures may improve the design and comparability of future out-of-hospital trials.
D004632:Emergency Medical Services / Q000706:statistics & numerical data*; D006302:Health Services Research; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D011654:Pulmonary Edema / Q000628:therapy*; D012107:Research Design