title: [Cellular fibroma of the ovary: description of a case].
abstract: Cellular fibromas of the ovary are rare neoplasms belonging to the group of sex-cord stromal tumours. They have been described to show from 1 to 3 mitotic figures per 10 high power fields (HPF) and they generally behave in a benign fashion. Herein we describe the clinicopathological features of a case of ovarian cellular fibroma. The patient, a 22-year-old woman, presented with acute abdominal pain. Laparotomy revealed a large ovarian mass. Histologically the lesion was composed of spindle cells showing slight or moderate pleomorphism and 3 mitoses per 10 HPF. The spindle cells were immunoreactive for vimentin, smooth muscle actin and inhibin alpha-subunit. The differential diagnoses that we considered included the mitotically active leiomyoma because of the strong positivity for smooth muscle actin, but positive immunoreaction with anti alpha-inhibin antibody helped in confirming a sex-cord stromal tumour. Electron microscopy did not show any evidence of smooth muscle differentiation.
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000737:chemistry / Q000145:classification / Q000601:surgery / Q000648:ultrastructure*; D006801:Humans; D007265:Inhibins / Q000032:analysis; D007889:Leiomyoma / Q000175:diagnosis; D008854:Microscopy, Electron; D008940:Mitotic Index; D009363:Neoplasm Proteins / Q000032:analysis; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000601:surgery / Q000648:ultrastructure*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000737:chemistry / Q000145:classification / Q000601:surgery / Q000648:ultrastructure*; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D014746:Vimentin; C094377:inhibin-alpha subunit; D007265:Inhibins
vernacular_title: Fibroma cellulato dell'ovaio: descrizione di un caso.