Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material.
The biocompatibility of nickel-titanium alloys was investigated by single-culture experiments on functionally graded samples with a stepwise change in composition from pure nickel to pure titanium, including an Ni-Ti shape memory alloy for a 50:50 mixture. This approach permitted a considerable decrease of experimental resources by simultaneously studying a full variation of composition. The results indicate a good biocompatibility for a nickel content up to about 50%. The cells used in the biocompatibility studies comprised osteoblast-like osteosarcoma cells (SAOS-2, MG-63), primary human osteoblasts (HOB), and murine fibroblasts (3T3).
D016475:3T3 Cells; D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials; D002460:Cell Line; D002478:Cells, Cultured; D003035:Cobalt / Q000737:chemistry; D018920:Coculture Techniques; D006801:Humans; D051379:Mice; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology*; D010006:Osteoblasts / Q000378:metabolism; D013997:Time Factors; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction; D014965:X-Rays
D000497:Alloys; D001672:Biocompatible Materials; C040654:titanium nickelide; D003035:Cobalt; D009532:Nickel; D014025:Titanium