Calcifying sclerosing tumor of the ovary: a late stage of sclerosing stromal tumor?
An unusual calcifying tumor of the ovary occurring in a 23-year-old woman is described. The tumor did not produce any endocrine symptoms. Histologically, it was paucicellular and displayed extensive sclerotic stroma with numerous calcifications. The fibroblast-like cells were arranged in vague pseudolobules thus resembling overall the architecture of the sclerosing stromal tumor (SST), but the hemangiopericytoma-like vasculature typical of SST was not seen. However, immunohistochemical endothelial markers CD31 and CD34 showed a surprisingly high number of small vessels that were not apparent in hematoxylin-eosin stained sections. The tumor cells were positive for alpha-inhibin, CD99, actin, and negative for desmin, S100 protein, and epithelial markers. This type of ovarian stromal tumor may represent a calcifying stage of SST.
D000328:Adult; D002114:Calcinosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000737:chemistry / Q000473:pathology*