title: Advanced issues in the design and conduct of randomized clinical trials: the bigger the better?
abstract: Large trials provide more precise estimates of treatment effects than small trial (how good is the treatment?) and they may allow a few sensible and pre-defined sub-group analyses (for whom does the treatment work best?). But large trials will not get done unless they are simple and as part of normal clinical practice as possible.
mesh_terms: D001281:Atrial Fibrillation / Q000473:pathology; D002339:Carotid Arteries / Q000601:surgery; D016893:Carotid Stenosis / Q000601:surgery; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D018401:Sample Size; D020521:Stroke / Q000517:prevention & control; D016896:Treatment Outcome