Investigation of hypoglycemic properties of rectal suppositories with chlorpropamide.
Rectal suppositories with chlorpropamide and suppositories with chlorpropamide in the dispersion system with urea were prepared. Witepsol H15 and H19 and a polyoxyethyleneglycol mixture were used as bases. Rabbits were tested for blood-glucose level. The animals have been administered with prepared suppositories and commercial tablets. It was found that the suppositories prepared on the basis Witepsol H 15 with the dispersed chlorpropamide caused a much higher decrease of blood-glucose level than commercial tablets.
D000285:Administration, Rectal; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002747:Chlorpropamide / Q000008:administration & dosage* / Q000737:chemistry; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D011817:Rabbits; D013488:Suppositories
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013488:Suppositories; D002747:Chlorpropamide