title: [Effect of atenolol and trimetazidine on dispersion of cardiac rhythm in patients with moderately expressed postinfarction left ventricular dysfunction].
abstract: OBJECTIVE
  To study effects of atenolol and trimetazidine on heart rhythm variability in postmyocardial infarction patients with moderate left ventricular dysfunction.
  
  
  METHODS
  Fifty postmyocardial infarction (PMI) patients participated in a 3-week randomized blind trial. They were divided into two groups given atenolol or trimetazidine. Time and spectral analyses of heart rhythm dispersion on short ECG parts (5 min) were done before and after treatment with atenolol (76.9 +/- 6.6 mg/day) or trimetazidine (60 mg/day).
  
  
  RESULTS
  Only course therapy with atenolol raised heart rhythm variability registered both by time and spectral analysis.
  
  
  CONCLUSIONS
  Studying heart rhythm variability enables efficient non-invasive control over effectiveness of neurohumoral heart unloading in the course of pharmacotherapy of ischemic left ventricular dysfunction.
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*; D018487:Ventricular Dysfunction, Left
chemical_list: D000889:Anti-Arrhythmia Agents; D014665:Vasodilator Agents; D001262:Atenolol; D014292:Trimetazidine
vernacular_title: Vliianie atenolola i trimetazidina na dispersiiu ritma serdtsa u bol'nykh s umerenno vyrazhennoĭ postinfarktnoĭ disfunktsieĭ levogo zheludochka.