title: Facile C21 functionalization through a novel functional group transfer reaction in 16 alpha,17 alpha-epoxy-3 beta-hydroxypregn-5-en-20-one and its applications.
abstract: A novel functional group transfer reaction in 16 alpha,17 alpha-epoxy-3 beta-hydroxypregn-5-en-20-one by treatment with dry HCl affords 21-chloro-3 beta-hydroxy-pregn-5,16-dien-20-one, which has been utilized to obtain a number of C21-substituted derivatives.
mesh_terms: D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry; D006908:Hydroxyprogesterones / Q000138:chemical synthesis / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C469814:16,17-epoxy-3-hydroxypregn-5-en-20-one; D004852:Epoxy Compounds; D006908:Hydroxyprogesterones; D013256:Steroids