title: [Cilazapril in the treatment of patients with arterial hypertension].
abstract: Effects of monotherapy with cilazapril, cilazapril in combination with hydrochlorothiazide and the latter two drugs combination with verapamil (or obsidan) were studied in 20 patients with mild arterial hypertension (AH), moderate AH (n = 23) and severe AH (n = 22). Cilazapril was administered in a single daily dose of 2.5-5 mg for 24 weeks. Four measurements of arterial pressure, echocardiography, estimation of total cholesterol, triglycerides, glucose tolerance tests were made before the treatment and on its weeks 4, 12 and 24. Mono- and combined therapy with cilazapril proved effective in the above patients as it optimally lowered blood pressure and induced a reverse development of left ventricular hypertrophy. 24 week therapy with this drug has a positive effect on the level of triglycerides and postprandial glycemia.
mesh_terms: D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D017315:Cilazapril / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D017315:Cilazapril
vernacular_title: Tsilazapril v lechenii bol'nykh arterial'noĭ gipertonieĭ.