Vascular-targeted molecular imaging using functionalized polymerized vesicles.
In this review we will discuss the use of multivalent polymerized vesicles (PVs) combined with magnetic resonance imaging (MRI) and gamma scintigraphy to image expression of vascular molecular receptors in vivo. Specifically, we will present our data on the use of this technology to design imaging agents toward specific vascular receptors in both a mouse and rabbit tumor model and in the EAE mouse, a model for human multiple sclerosis (MS). Examples will be shown where the in vivo specificity of the targeted molecular imaging agents was validated in the animal models. Since the PVs are designed to carry either contrast or therapeutic agents or both, we can potentially use vascular-targeted imaging for selecting patients and guiding vascular-targeted therapies in these patients. Using this combined vascular-targeted imaging and therapy approach, personalized treatment can potentially be delivered, maximizing efficacy and minimizing side effects.
D000818:Animals; D003287:Contrast Media; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011817:Rabbits; D011877:Radionuclide Imaging
D003287:Contrast Media; D016023:Integrins; D018799:Intercellular Adhesion Molecule-1