[Intestinal metaplasia at the esophagogastric junction. Prevelence and association in patients undergoing endoscopy].
OBJECTIVE
Short segments of intestinal metaplasia (IM) at the esophagogastric junction is an unclear entity. Several studies have reported wide variations in its prevalence and in the factors associated with its development. Recently, this entity has been divided into esophageal IM and cardiac IM, as two different lesions in etiopathogenesis and prognosis. We studied the prevalence of these conditions and their association with gastroesophageal reflux disease (GERD) and Helicobacter pylori infection.


METHODS
In 161 patients, biopsies were obtained from the distal esophagus (2), just below the Z line (3), and in the gastric antrum (4). IM was diagnosed on the basis of staining of goblet cells with Alcian blue and was classified as esophageal if ILZ < IEG or cardiac ILZ = IEG. H. pylori was determined by rapid urease (CLO-test) and histology. Diagnosis of GERD was based on typical symptoms, endoscopy, and histology. In 54 patients with IM (73%) esophageal manometry and 24-hour pH-metry was also performed.


RESULTS
IM was detected in 74 patients (46%); IM was esophageal in 33 patients (20.5%) and cardiac in 41 patients (25.4%). Patients with IM were significantly older than those without (p = 0.007) and took proton pump inhibitors more frequently (p = 0.004). No correlation was found between reflux symptoms, esophageal lesions or histological changes with either type of IM. No differences between esophageal or cardiac IM were detected by esophageal pH-metry. H. pylori infection was unrelated to cardiac IM, but these patients had a lower frequency of endoscopic and histological changes in the distal esophagus.


CONCLUSIONS
Intestinal metaplasia is a common finding in patients sent for gastroscopy and is probably an acquired lesion that increases in prevalence with age. We found no associations between esophageal IM and GERD, evaluated by typical symptoms, endoscopic and histological changes and pH-metry. H. pylori infection showed no relation to cardiac IM.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000032:analysis; D002299:Cardia / Q000473:pathology*; D015897:Comorbidity; D016145:Endoscopy, Digestive System; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D005745:Gastric Acidity Determination; D005756:Gastritis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000473:pathology; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D016480:Helicobacter pylori / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D007421:Intestine, Small; D008297:Male; D008365:Manometry; D008679:Metaplasia; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013194:Staining and Labeling; D014510:Urease / Q000032:analysis
D001426:Bacterial Proteins; D014510:Urease
Metaplasia intestinal en la unión esofagogástrica. Prevalencia y asociaciones en una población sometida a endoscopia.