title: The behavioral and cognitive effects of two benzodiazepines associated with drug-facilitated sexual assault.
abstract: Recently, sexual assaults have included the use of benzodiazepines to impair the victim. Our aim was to examine the physiological, cognitive, and behavioral effects of flunitrazepam (FN) and clonazepam (CLO). In the first study, ten healthy volunteers received a single oral dose of 2 mg of FN. Mini Mental State Examination (MMSE), behavioral reports and staff observations were then collected. In the second study, ten healthy volunteers received a single oral dose of 3 mg of CLO. Vital signs, performance on the MMSE and Digit Symbol Substitution Test, and behavioral changes were examined. FN significantly decreased systolic and diastolic blood pressure 4 h post drug ingestion with diastolic remaining low at 6 h. CLO was associated with changes in temperature and decreased systolic pressure. FN affected memory and attention 4 h following ingestion. CLO affected memory and attention throughout the study (6 h), and psychomotor performance was decreased 2 h post ingestion. In both studies, subjects were disinhibited and did not perceive their own impairment.
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects; D002998:Clonazepam / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D005445:Flunitrazepam / Q000009:adverse effects / Q000494:pharmacology*; D018757:GABA Modulators / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D011902:Rape; D016320:Substance Abuse Treatment Centers
chemical_list: D014151:Anti-Anxiety Agents; D018757:GABA Modulators; D002998:Clonazepam; D005445:Flunitrazepam