title: Low-dose ethanol alters the cardiovascular, metabolic, and respiratory compensation for severe blood loss.
abstract: BACKGROUND
  Compensation for hemorrhage and shock requires coordination of responses and sufficient physiologic reserve capacity of the cardiovascular, respiratory, renal, and neuroendocrine systems. Intake of ethanol (EtOH) is known to degrade physiologic response to stress. The purpose of this study was to investigate how acute EtOH exposure changes responses to severe blood loss, shock, and resuscitation.
  
  
  METHODS
  Conscious male Duncan Hartley guinea pigs were given an intraperitoneal injection of either EtOH (1 g/kg) or an equal volume of water 30 minutes before controlled hemorrhage (60% blood volume), resuscitated after 30 minutes of hypovolemia with a lactated Ringer's solution volume equal to that of the shed blood volume, and observed for 24 hours. Hemodynamic (heart rate, arterial blood pressure), clinical laboratory (arterial blood gases, glucose, lactate, hematocrit), and metabolic gas exchange (oxygen consumption, carbon dioxide production) indicators of shock were monitored.
  
  
  RESULTS
  Of the animals that survived 24 hours, changes in arterial pH and lactate were significantly greater in the experiment group than in the control group. Mortality at 24 hours was 77% in the experiment group (EtOH-treated) and 42% (p = 0.39) in the control group (water-treated).
  
  
  CONCLUSIONS
  Acute EtOH exposure, with blood EtOH concentration similar to legal intoxication levels, limits physiologic reserve during hemorrhagic shock and resuscitation. In survivors of shock and resuscitation, compensation is compromised and physiologic reserve is adversely affected by acute EtOH intake.
mesh_terms: D000435:Alcoholic Intoxication / Q000503:physiopathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000378:metabolism; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006168:Guinea Pigs; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010101:Oxygen Consumption; D012119:Respiration / Q000187:drug effects*; D012151:Resuscitation / Q000379:methods*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002245:Carbon Dioxide; D019344:Lactic Acid; D000431:Ethanol