title: Age-related changes in skin wrinkles assessed by a novel three-dimensional morphometric analysis.
abstract: BACKGROUND
  A system has been developed whereby the morphology of the skin surface can be evaluated directly in three dimensions. This system employs a non-invasive device that utilizes white light of halogen origin, and which allows the computation of wrinkle depth and width, and other parameters of skin surface morphology. Using innovative engineering, an optical system has been devised so that light is transmitted via a slit and can be used to measure not only replicas of the skin but also the skin surface directly. The measurement area is 6.4 x 6.4 mm, and the theoretical resolution with a x 50 magnification lens is within 12.5 micro m.
  
  
  OBJECTIVE
  To use this system to study age-related changes in the morphology of wrinkles at the eye corner areas of women of varying ages.
  
  
  METHODS
  One hundred and one healthy women (age range 20-80 years) residing in the Tokyo area were the subjects used in this study.
  
  
  RESULTS
  Wrinkles demonstrated a rapid increase in depth in women aged 40 years or older, and plateaued at the age of 60 years. Surface morphology parameters yielded results similar to those of age-related changes in wrinkles.
  
  
  CONCLUSIONS
  This new analytical system provides a rapid and convenient non-invasive method to evaluate skin surface morphology in three dimensions, especially with respect to wrinkle formation. The results obtained using this system provide a deeper insight into the mechanistic relationship between wrinkles and skin elasticity.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D004548:Elasticity; D005145:Face; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008875:Middle Aged; D016628:Replica Techniques; D012867:Skin / Q000503:physiopathology; D015595:Skin Aging / Q000473:pathology* / Q000502:physiology