Analysis of -631 and -475 interleukin-2 promoter single nucleotide polymorphisms in multiple sclerosis.
We have analysed the interleukin-2 (IL-2) promoter single nucleotide polymorphisms -475 A/T and -631 G/A, relative to the initiation codon, in patients with multiple sclerosis (MS) and in healthy controls. Both groups showed a very low frequency of T at -475 and A at -631. Our results suggest that these polymorphisms do not contribute to MS susceptibility.
D020022:Genetic Predisposition to Disease; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D044465:White People
D007376:Interleukin-2