title: Bioactive constituents of Cedrelopsis microfoliata.
abstract: The stem bark of Cedrelopsis microfoliata has yielded the new compounds microfolian (1), microfolione (2), and microfolicoumarin (6) along with the known compounds agrandol (3), cedrecoumarin A (4), obliquin (5), and sesquichamaenol (7). Compounds 2-4 were found to show agonistic activity on both alpha- and beta-estrogenic receptors, and compounds 1, 3, and 4 were shown to inhibit the chemiluminescence of reactive oxygen metabolites and showed superoxide scavenging activity.
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007668:Kidney; D008156:Luciferases / Q000378:metabolism; D008163:Luminescent Measurements; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011960:Receptors, Estrogen / Q000378:metabolism; D029631:Sapindaceae / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D016166:Free Radical Scavengers; D011960:Receptors, Estrogen; D008156:Luciferases