Stereostructure of a novel cytotoxic 18-membered macrolactone antibiotic FD-891.
The absolute stereochemistry of FD-891, a novel cytotoxic 18-membered macrolactone antibiotic, was determined by a synthetic approach as well as X-ray diffraction of degradative derivatives. The absolute configuration of FD-891 turned out to be as shown above. The stable conformer of FD-891 was also discussed with respect to biological activity by comparison with the structurally related concanamycin A on the bases of molecular mechanics calculations. [structure: see text]
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000633:toxicity*; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D018942:Macrolides; C091118:FD 891; C036978:concanamycin A