title: Microfluidic large-scale integration.
abstract: We developed high-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated microfluidic networks to construct the microfluidic analog of a comparator array and a microfluidic memory storage device whose behavior resembles random-access memory.
mesh_terms: D001671:Biochemistry / Q000295:instrumentation* / Q000379:methods; D001978:Bromphenol Blue; D004396:Coloring Agents; D003201:Computers; D003578:Cytochrome-c Peroxidase / Q000378:metabolism; D004581:Electronics; D004926:Escherichia coli / Q000201:enzymology / Q000302:isolation & purification; D020869:Gene Expression Profiling / Q000295:instrumentation*; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins / Q000378:metabolism; D008904:Miniaturization; D011312:Pressure; D012828:Silicones
chemical_list: D004396:Coloring Agents; D008164:Luminescent Proteins; D012828:Silicones; D001978:Bromphenol Blue; D049452:Green Fluorescent Proteins; D003578:Cytochrome-c Peroxidase