Fullerenes in medicinal chemistry and their biological applications.
The isolation and preparation ten years ago of the fullerenes in bulk quantities, sparked off a truly remarkable interdisciplinary research activity, encompassing diverse fields of chemistry, physics, materials science and medicinal chemistry. Pharmaceutical and biological studies have revealed that fullerene-based compounds exhibit various types of biological activity either in vitro or in vivo and are discussed in this review.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003287:Contrast Media; D004247:DNA / Q000187:drug effects; D004579:Electron Transport / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010778:Photochemotherapy; D015398:Signal Transduction / Q000187:drug effects
D000975:Antioxidants; D003287:Contrast Media; D004791:Enzyme Inhibitors; D002244:Carbon; D004247:DNA