Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers.
Apolipoprotein(a) (Apo(a)) is a glycoprotein that is linked by a disulfide bond to apolipoprotein B on low density lipoprotein particles to form lipoprotein(a) (Lp(a)). High plasma levels of Lp(a) are thought to contribute directly to the development of atherosclerosis. We tested a variant (T3888P) located in the Kringle-IV region of Apo(a) in a case-control series. Overall, there were no differences between case and controls. However, in the apoE2 positive subgroup, we noticed that the mutant allele is over-represented in the cases (P=0.005). We suggest that this polymorphism and others at the Apo(a) locus be further studied in relation to Alzheimer's disease.
D000544:Alzheimer Disease / Q000235:genetics*; D053329:Apolipoprotein E2; D001053:Apolipoproteins / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D053241:Apoprotein(a); D016022:Case-Control Studies; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D018082:Kringles / Q000235:genetics; D017270:Lipoprotein(a) / Q000235:genetics*; D017354:Point Mutation
D053329:Apolipoprotein E2; D001053:Apolipoproteins; D001057:Apolipoproteins E; D017270:Lipoprotein(a); D053241:Apoprotein(a)