title: Once the circle has been broken: dynamics and evolution of Streptomyces chromosomes.
abstract: Chromosomal instability has been a hallmark of Streptomyces genetics. Deletions and circularization often occur in the less-conserved terminal sequences of the linear chromosomes, which contain swarms of transposable elements and other horizontally transferred elements. Intermolecular recombination involving these regions also generates gross exchanges, resulting in terminal inverted repeats of heterogeneous size and context. The structural instability is evidently related to evolution of the Streptomyces chromosomes, which is postulated to involve linearization of hypothetical circular progenitors via integration of a linear plasmid. This scenario is supported by several bioinformatic analyses.
mesh_terms: D005075:Biological Evolution; D002876:Chromosomes, Bacterial / Q000235:genetics*; D019295:Computational Biology; D004251:DNA Transposable Elements / Q000235:genetics; D008957:Models, Genetic; D010957:Plasmids / Q000235:genetics; D013302:Streptomyces / Q000235:genetics*; D020079:Terminal Repeat Sequences
chemical_list: D004251:DNA Transposable Elements