title: Functional and evolutionary analysis of a eukaryotic parasitic genome.
abstract: The DNA sequences of the 11 linear chromosomes of the approximately 2.9 Mbp genome of Encephalitozoon cuniculi, an obligate intracellular parasite of mammals, include approximately 2000 putative protein-coding genes. The compactness of this genome is associated with the length reduction of various genes. Essential functions are dependent on a minimal set of genes. Phylogenetic analysis supports the hypotheses that microsporidia are related to fungi and have retained a mitochondrion-derived organelle, the mitosome.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D009670:Encephalitozoon cuniculi / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D005057:Eukaryotic Cells; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D010802:Phylogeny; D015800:Protozoan Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D015800:Protozoan Proteins