Open the loop: dissecting feedback regulation of a second messenger transduction cascade.
Single photon responses were compared in wild-type and transgenic retinal rods with and without guanylate cyclase activating protein (GCAP) to disrupt Ca(2+)-dependent feedback regulation of guanylate cyclase (see Burns et al. in this issue of Neuron). The results provided new insights into the molecular mechanisms underlying phototransduction.
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism; D005246:Feedback / Q000502:physiology*; D006162:Guanylate Cyclase / Q000378:metabolism*; D051604:Guanylate Cyclase-Activating Proteins; D006801:Humans; D017948:Retinal Rod Photoreceptor Cells / Q000166:cytology / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology*
D002135:Calcium-Binding Proteins; D051604:Guanylate Cyclase-Activating Proteins; D006162:Guanylate Cyclase; D006152:Cyclic GMP