ER quality control: a function for sugars in the cytosol.
Misfolded glycoproteins in the endoplasmic reticulum of a eukaryotic cell are exported to the cytosol, where they are proteolytically degraded by the ubiquitin-proteasome system. A recent study has identified a novel E3 ubiquitin ligase that recognises target glycoproteins via their sugar moieties.
D003600:Cytosol / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism*; D008025:Ligases / Q000378:metabolism*; D017510:Protein Folding; D025801:Ubiquitin / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases
D006023:Glycoproteins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D008025:Ligases