title: Chabamide, a novel piperine dimer from stems of Piper chaba.
abstract: A novel piperine dimer, named chabamide, was isolated from stems of Piper chaba Hunter and its structure was elucidated on the basis of spectroscopic evidence. Chabamide showed antimalarial activity with an IC(50) value of 2.7 microg/ml and antituberculosis activity with the minimum inhibitory concentration (MIC) of 12.5 microg/ml.
mesh_terms: D000470:Alkaloids; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D052117:Benzodioxoles; D019281:Dimerization; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D031701:Piper; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D053284:Polyunsaturated Alkamides
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000995:Antitubercular Agents; D052117:Benzodioxoles; D010880:Piperidines; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; C469492:chabamide; C008922:piperine