Possible participation of endotoxin of gram-negative bacteria in pathogenesis of liver damage during viral hepatitis.
Possible role of gram-negative bacteria in the genesis of hepatic damage during chronic viral hepatitis B and C was studied. Histological activity, hepatocyte proliferative activity, and expression of alpha-smooth muscle actin were compared with the severity of endotoxemia in patients with chronic hepatitis B and C. The study revealed a correlation between the degree of intralobular necroses, hepatocyte proliferation, and myofibroblast transdifferentiation of Ito cells with endotoxin concentration in the blood.
D001707:Biopsy, Needle; D004731:Endotoxins / Q000633:toxicity*; D006090:Gram-Negative Bacteria / Q000472:pathogenicity*; D019694:Hepatitis B, Chronic / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D016133:Polymerase Chain Reaction; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism
D004731:Endotoxins; D018809:Proliferating Cell Nuclear Antigen