Effect of tomato intake on striatal monoamine level in a mouse model of experimental Parkinson's disease.
An ingestion of tomato powder rich in lycopene was examined for its effect on mice with Parkinson's disease-like syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To assess the preventive effect of tomato against the MPTP-induced selective destruction of dopaminergic nigrostrie, we determined striatal dopamine (DA). A 4-wk ingestion of the experimental diet containing 20% (w/w) lyophilized tomato powders before MPTP treatment prevented a decrease in the DA level. This suggests that the tomato ingestion might serve as a preventive against neurodegenerative diseases such as Parkinson's disease caused by MPTP and other environmental toxins.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D015306:Biogenic Monoamines / Q000032:analysis*; D001835:Body Weight; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000032:analysis; D015259:Dopamine Agents; D000077276:Lycopene; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000517:prevention & control*; D011897:Random Allocation
D015306:Biogenic Monoamines; D015259:Dopamine Agents; D002338:Carotenoids; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000077276:Lycopene; D004298:Dopamine