title: Preoperative supraphysiological testosterone in older men undergoing knee replacement surgery.
abstract: OBJECTIVE
  Older patients undergoing knee replacement surgery can recover more slowly than younger patients and require extended rehabilitation. Because administration of supraphysiological testosterone (T) dramatically increases strength, we hypothesized that preoperative T therapy would improve functional recovery and reduce hospital stay in older men undergoing knee replacement surgery.
  
  
  METHODS
  Double-blinded, placebo-controlled pilot trial.
  
  
  METHODS
  A Veterans Affairs orthopedics clinic and inpatient postoperative unit.
  
  
  METHODS
  Twenty-five men, mean age 70, undergoing elective knee replacement.
  
  
  METHODS
  Preoperative, supraphysiological T administration (600 mg T enanthate intramuscularly weekly for 4 weeks) or sesame oil placebo.
  
  
  METHODS
  Length of hospital stay and functional ability by Functional Independence Measure (FIM) score.
  
  
  RESULTS
  Mean length of hospital stay +/- standard deviation was nonsignificantly reduced in the T group (5.9 +/- 2.4 days vs 6.8 +/- 2.5 days; P =.15). At postoperative Day 3, there was a significant improvement in ability to stand (mean FIM score 5.2 +/- 1.0 vs 4.0 +/- 1.1; P =.04) and trends towards improvements in walking and stair climbing in the T group. There were no complications attributable to T therapy.
  
  
  CONCLUSIONS
  In older men undergoing knee replacement surgery, preoperative supraphysiological T administration may confer some clinical benefit. Future studies using longer courses of preoperative T administration in larger numbers of older men undergoing knee replacement surgery are warranted.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000534:rehabilitation*; D004311:Double-Blind Method; D006801:Humans; D007273:Injections, Intramuscular; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011300:Preoperative Care; D020127:Recovery of Function; D013739:Testosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013739:Testosterone