Access of reproductive steroids to target tissues.
The access of reproductive steroids to their target cells varies considerably between tissues, and is influenced to a great extent by their interactions with plasma steroid-binding proteins, and with SHBG and CBG in particular. An increased awareness of how SHBG and CBG function within the blood circulation, and within extravascular compartments of steroid-responsive target tissues, needs to be incorporated into the design and evaluation of therapies involving the administration of both natural and synthetic steroids, which influence female reproduction and healthy aging.
D005260:Female; D005836:Genitalia, Female / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D012098:Reproduction / Q000502:physiology; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D014018:Tissue Distribution; D014156:Transcortin / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin; D014156:Transcortin