[Steroid hormonal receptors, heat shock protein and p53 of endometrioid and clear cell cancers in different localization].
OBJECTIVE
Most endometrioid, well differentiated cancers are positive for ER and PgR.


METHODS
By using specific monoclonal antiER, PgR, p53 and hsp 90 antibodies, immunohistochemical reaction was used to study paraffin-embedded specimens from 53 patients with primary endometrioid and clear cell cancers.


RESULTS
Most carcinomas with p53 overexpression showed no reactivities of ER and PgR.


CONCLUSIONS
Presence of p53 and absence of steroid hormone receptors suggest a poor clinical prognosis for patients with endometrioid and clear cell cancers.
D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000473:pathology*; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018841:HSP90 Heat-Shock Proteins / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis* / Q000276:immunology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000276:immunology; D015854:Up-Regulation
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D018841:HSP90 Heat-Shock Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D016159:Tumor Suppressor Protein p53
Receptory dla hormonów steroidowych, białko szoku termicznego i p53 w rakach endometrioidalnych i jasnokomórkowych o róznej lokalizacji.