title: Converting solution macromolecular thermodynamic properties into gas-phase mass spectrometry observations.
abstract: Solution dissociation constants and changes in free energies associated with ligand binding to proteins have been measured in the gas phase using mass spectrometry.
mesh_terms: D007700:Kinetics; D008024:Ligands; D046911:Macromolecular Substances; D009696:Nucleic Acids / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D013816:Thermodynamics
chemical_list: D008024:Ligands; D046911:Macromolecular Substances; D009696:Nucleic Acids; D011506:Proteins