title: Mechanical factors in the production of coronary atheromata--old thoughts and new discoveries.
abstract: The role of mechanical factors and hemodynamic shear stress in the production of coronary atheromatous disease appears certain. Its propagation is influenced by a variety of genetic transformations, disease states, and biofunctional and extraneous factors. Recent research attests to the high degree of complexity of the biochemical and physiologic processes involved. It is hoped that continued research will produce results that will allow the clinician to halt or reverse the process.
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology; D001696:Biomechanical Phenomena; D003324:Coronary Artery Disease / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D012106:Research; D012307:Risk Factors; D013314:Stress, Mechanical; D014732:Vibration