title: Application of the biotic ligand model to predicting zinc toxicity to rainbow trout, fathead minnow, and Daphnia magna.
abstract: The Biotic Ligand Model has been previously developed to explain and predict the effects of water chemistry on the toxicity of copper, silver, and cadmium. In this paper, we describe the development and application of a biotic ligand model for zinc (Zn BLM). The data used in the development of the Zn BLM includes acute zinc LC50 data for several aquatic organisms including rainbow trout, fathead minnow, and Daphnia magna. Important chemical effects were observed that influenced the measured zinc toxicity for these organisms including the effects of hardness and pH. A significant amount of the historical toxicity data for zinc includes concentrations that exceeded zinc solubility. These data exhibited very different responses to chemical adjustment than data that were within solubility limits. Toxicity data that were within solubility limits showed evidence of both zinc complexation, and zinc-proton competition and could be well described by a chemical equilibrium approach such as that used by the Zn BLM.
mesh_terms: D000818:Animals; D003530:Cyprinidae / Q000378:metabolism*; D003621:Daphnia / Q000187:drug effects / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D017686:Oncorhynchus mykiss / Q000378:metabolism*; D011237:Predictive Value of Tests; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000633:toxicity*
chemical_list: D008024:Ligands; D014867:Water; D015032:Zinc