title: Inelastic vascular prosthesis for proximal aorta increases pulsatile arterial load and causes left ventricular hypertrophy in dogs.
abstract: OBJECTIVE
  Elastic property of the proximal aorta plays an important role in reducing pulsatile load to the ventricle. When a stiff vascular prosthesis is used for the proximal aorta, the pulsatile load increases. We designed this study to elucidate whether the increase in pulsatile load caused left ventricular hypertrophy.
  
  
  METHODS
  We created an ascending aorta-abdominal aorta bypass in 9 dogs with a noncompliant vascular prosthesis. The aortic arch proximal to the left subclavian artery was occluded to direct blood flow into the bypass. Closed chest studies were performed after a median of 139 days (range 45-588) days. We assessed the pulsatile load of the ventricle by calculating characteristic impedance from pressure and flow velocity in the ascending aorta. The left ventricle was weighed, normalized with body weight, and compared with the control group, which had sham operations (7 dogs).
  
  
  RESULTS
  Characteristic impedance of the bypassed dogs was 175% higher than the control (0.146 +/- 0.056 vs 0.053 +/- 0.014 mm Hg. s. mL(-1), P =.009), which resulted in wider pulse pressure (57 +/- 11 vs 25 +/- 11 mm Hg, P <.001). No difference was found in arterial resistance, cardiac output, or systolic blood pressure. Left ventricular weight normalized by body weight was significantly heavier in the bypass group (5.61 +/- 0.75 vs 4.15 +/- 0.62 g/kg, P =.001).
  
  
  CONCLUSIONS
  Since there was no increase in arterial resistance, we conclude that the increase in pulsatile load was the cause of left ventricular hypertrophy. A stiff vascular prosthesis used for the proximal aorta may cause left ventricular hypertrophy.
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D002302:Cardiac Output / Q000502:physiology*; D004285:Dogs; D017379:Hypertrophy, Left Ventricular / Q000209:etiology* / Q000503:physiopathology; D011474:Prosthesis Design; D014655:Vascular Resistance