Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis.
The maturation of the vascular system and the adjustment of blood vessel density in tissues require the opposing processes of vessel growth and regression. A new study in this issue of Developmental Cell shows that Angiopoietin-2 (Ang2), a ligand for the endothelial Tie2 receptor tyrosine kinase, has a dual function in the processes of postnatal angiogenesis and vascular remodeling. Also, Ang2 signals are required for the proper development and function of the lymphatic vessels.
D043925:Angiogenesis Inducing Agents / Q000502:physiology*; D042702:Angiopoietin-2; D000818:Animals; D001808:Blood Vessels / Q000254:growth & development* / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D008208:Lymphatic System / Q000254:growth & development* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction
D043925:Angiogenesis Inducing Agents; D042702:Angiopoietin-2; D016228:Endothelial Growth Factors; D010982:Platelet-Derived Growth Factor; D020794:Receptor Protein-Tyrosine Kinases