title: Malignant melanoma of the lip spreading in a pagetoid manner into the minor salivary glands.
abstract: We describe a malignant melanoma of the lower lip that upon recurrence extended in a pagetoid manner into the ducts of the oral minor salivary glands. Immunohistochemistry with antibodies to MART-1 and HMB-45 confirmed that the atypical cells in the ducts of the salivary glands were indeed melanoma cells. Pathologists involved in staging of oral melanoma are urged to look out for this previously unreported mode of spread of labial malignant melanoma.
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008048:Lip Neoplasms / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000473:pathology*; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local; D018987:Salivary Ducts / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm; D000939:Epitopes; C105787:MART-1-Melan-A(27-35) epitope; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins