Effect of xenon on cerebral autoregulation in pigs.
There are little data on the effect of anaesthetic concentrations of xenon on cerebral pressure autoregulation. In this study, we have investigated the effect of 79% xenon inhalation on cerebral pressure autoregulation and CO2 response in pigs. Ten pigs were randomly allocated to receive xenon 79% or halothane anaesthesia, respectively, in a crossover designed study. Halothane was used to validate the experimental set-up. Transcranial Doppler was performed to determine the mean flow velocities in the middle cerebral artery (vMCA) during defined cerebral perfusion pressures and during normo-, hyper- and hypoventilation. The results showed that the inhalation of 79% xenon preserved cerebral autoregulation during conditions of normo-, hyper- and hypoventilation and at different cerebral perfusion pressures in pigs. These results suggest that with the inhalation of xenon, in the highest concentration suitable for a safe clinical use, cerebral autoregulation is preserved.
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects; D018592:Cross-Over Studies; D006221:Halothane / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007427:Intracranial Pressure / Q000187:drug effects*; D010313:Partial Pressure; D013552:Swine; D017585:Ultrasonography, Doppler, Transcranial; D014978:Xenon / Q000494:pharmacology*
D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D014978:Xenon; D006221:Halothane