AlCl(3) x 6H(2)O/KI/H(2)O/CH(3)CN: a new alternate system for dehydration of oximes and amides in hydrated media.
Dehydration of oximes and amides to nitriles was carried out using the AlCl(3) x 6H(2)O/KI/H(2)O/CH(3)CN system. It produced isoquinoline derivatives 8a-c (Bischler Naperialski reaction) when reacted with amides 7a-c in hydrated media. Also, the keto oximes produced anilides (Beckmann rearrangement) with the system under the same reaction conditions.