Matching gene expression with hypometabolism after cerebral ischemia in the nonhuman primate.
To correlate brain metabolic status with the molecular events during cerebral ischemia, a cDNA array was performed after positron emission tomography scanning in a model of focal cerebral ischemia in baboons. Cluster analysis for the expression of 74 genes allowed the identification of 4 groups of genes. In each of the distinct groups, the authors observed a marked inflection in the pattern of gene expression when the CMRo was reduced by 48% to 66%. These patterns of coordinated modifications in gene expression could define molecular checkpoints for the development of an ischemic infarct and a molecular definition of the penumbra.
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002545:Brain Ischemia / Q000235:genetics* / Q000378:metabolism; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology; D003001:Cloning, Molecular; D016000:Cluster Analysis; D018076:DNA, Complementary; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D010101:Oxygen Consumption; D010215:Papio
D018076:DNA, Complementary