Will a partial posterior annuloplasty ring prevent acute ischemic mitral regurgitation?
BACKGROUND
Acute posterolateral ischemia in sheep results in ischemic mitral regurgitation (IMR). While complete ring annuloplasty prevents acute IMR, partial annuloplasty rings may offer a more physiologic repair, but are untested in animal models of IMR.


METHODS
Radiopaque markers were placed on the LV, mitral annulus (MA), and leaflets in 13 sheep. Seven sheep served as controls, and 6 had a St. Jude Tailor partial flexible ring implanted (29 mm in 5, 31 mm in 1). After 8+/-1 day, the animals were studied with biplane videofluoroscopy and echocardiography before and during acute posterolateral LV ischemia (balloon occlusion of circumflex artery). Mitral annular area (MAA), septal-lateral annular diameter (SL), annular perimeters, and leaflet edge separation were calculated from 3-D marker coordinates.


RESULTS
The average degree of mitral regurgitation increased from 0.0+/-0.0 to 2.1+/-0.7 (P=0.0006) in the control group during acute ischemia but remained unchanged in the Tailor group (0.1+/-0.2 for both conditions). The change in MAA throughout the cardiac cycle before ischemia was 17+/-4% in control animals, but only 5+/-2% (P=0.0002) in the Tailor ring group. Unlike the control animals, there was no increase in MAA (5.4+/-0.8 and 5.5+/-0.7 cm(2), respectively; p=NS) nor dilatation of the muscular annulus (6.2+/-0.3 and 6.2+/-0.4, respectively; p=NS) during ischemia with the Tailor ring. Mitral SL dimension increased slightly with ischemia (2.3+/-0.2 versus 2.2+/-0.2 cm, P=0.03). Although posterior leaflet motion was limited, as observed with complete rings, normal annular flexion was maintained with the Tailor ring before and during acute ischemia.


CONCLUSIONS
The Tailor partial annuloplasty ring prevented acute IMR probably by limiting SL diameter dilatation during acute ischemia. In this animal model of acute IMR, a partial, flexible posterior annuloplasty ring is as effective as a complete ring.
D000208:Acute Disease; D000818:Animals; D003287:Contrast Media; D017548:Echocardiography, Transesophageal; D005471:Fluoroscopy; D006439:Hemodynamics; D007700:Kinetics; D018715:Microscopy, Video; D008943:Mitral Valve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D017202:Myocardial Ischemia / Q000601:surgery*; D012756:Sheep
D003287:Contrast Media