title: High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
abstract: Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. To determine its usefulness as a predictor of DHF, plasma levels of the secreted dengue virus nonstructural protein NS1 (sNS1) were measured daily in 32 children with dengue-2 virus infections participating in a prospective, hospital-based study. Free sNS1 levels in plasma correlated with viremia levels and were higher in patients with DHF than in those with DF. An elevated free sNS1 level (> or =600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF.
mesh_terms: D000293:Adolescent; D002648:Child; D003716:Dengue Virus / Q000276:immunology / Q000302:isolation & purification*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D019595:Severe Dengue / Q000097:blood / Q000503:physiopathology* / Q000821:virology*; D013997:Time Factors; D017361:Viral Nonstructural Proteins / Q000097:blood*; D014766:Viremia / Q000097:blood / Q000821:virology
chemical_list: C079340:NS1 protein, Dengue virus type 2; D017361:Viral Nonstructural Proteins