title: Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high pi-facial selectivity: a synthetic study towards scyphostatin.
abstract: The Diels-Alder reaction of spirolactones with cyclopentadiene afforded the adduct with high pi-facial selectivity; a hydrophilic analogue of scyphostatin was synthesized from the Diels-Alder adduct.
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D003512:Cyclohexanones / Q000138:chemical synthesis*; D011753:Pyrones / Q000138:chemical synthesis*; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D000577:Amides; D003512:Cyclohexanones; D011753:Pyrones; C121123:scyphostatin; D013148:Spironolactone