title: Seasonal variation in the incidence of deep vein thrombosis in patients with deficiency of protein C or protein S.
abstract: An attempt was made to identify circaseptanal or seasonal variation of deep vein thrombosis (DVT) in a population with protein C or protein S deficit. Forty-four patients with DVT and protein C or protein S deficit were studied for 1 year. A significant circannual rhythm was found for the total population that peaked during winter. There was also a significant falling circaseptanal rhythm on Fridays. These observations may optimize an adequate and precise anticoagulant therapy in patients with protein C or protein S deficits.
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020151:Protein C Deficiency / Q000150:complications* / Q000453:epidemiology; D018455:Protein S Deficiency / Q000150:complications* / Q000453:epidemiology; D012621:Seasons; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology*; D014937:Work / Q000502:physiology
chemical_list: D000925:Anticoagulants