Association analysis of polymorphisms in the interleukin-4 receptor (alpha) gene with atopic asthma in patients from western Mexico.
We undertook an association analysis between the ile50val, glu375ala, cys406arg, and ser761pro polymorphisms of the IL-4Ralpha gene and atopic asthma, total IgE levels and IL-4 serum levels in a population from western Mexico. We found that the ser761pro polymorphism was monomorphic for ser761, while there was no association between any of the other polymorphisms and the three phenotypes analysed.
D019943:Amino Acid Substitution; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008800:Mexico / Q000453:epidemiology; D011110:Polymorphism, Genetic; D019948:Receptors, Interleukin-4 / Q000235:genetics*
D019948:Receptors, Interleukin-4; D015847:Interleukin-4; D007073:Immunoglobulin E