[Effect of atenolol and trimetazidine on dispersion of cardiac rhythm in patients with moderately expressed postinfarction left ventricular dysfunction].
OBJECTIVE
To study effects of atenolol and trimetazidine on heart rhythm variability in postmyocardial infarction patients with moderate left ventricular dysfunction.


METHODS
Fifty postmyocardial infarction (PMI) patients participated in a 3-week randomized blind trial. They were divided into two groups given atenolol or trimetazidine. Time and spectral analyses of heart rhythm dispersion on short ECG parts (5 min) were done before and after treatment with atenolol (76.9 +/- 6.6 mg/day) or trimetazidine (60 mg/day).


RESULTS
Only course therapy with atenolol raised heart rhythm variability registered both by time and spectral analysis.


CONCLUSIONS
Studying heart rhythm variability enables efficient non-invasive control over effectiveness of neurohumoral heart unloading in the course of pharmacotherapy of ischemic left ventricular dysfunction.
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*; D018487:Ventricular Dysfunction, Left
D000889:Anti-Arrhythmia Agents; D014665:Vasodilator Agents; D001262:Atenolol; D014292:Trimetazidine
Vliianie atenolola i trimetazidina na dispersiiu ritma serdtsa u bol'nykh s umerenno vyrazhennoĭ postinfarktnoĭ disfunktsieĭ levogo zheludochka.