title: Abdominal pain and preeclampsia: sonographic findings in the maternal liver.
abstract: OBJECTIVE
  To describe sonographic findings in livers of pregnant women with severe preeclampsia and abdominal pain.
  
  
  METHODS
  Over a 12-month period, we performed serial sonographic examinations on 32 pregnant women with severe preeclampsia and acute right upper quadrant and epigastric pain. On each sonogram we observed the liver size and texture, "periportal halo" sign, gallbladder wall, Glisson capsule thickness, painful compression of the liver and gallbladder, and ascites. The pancreas, spleen, kidneys, and uterus were also studied. Sonography was repeated after delivery.
  
  
  RESULTS
  Initial sonograms showed liver abnormalities in 28 patients. Abnormalities consisted of liver hypertrophy (n = 24), hyperechoic thickening of the periportal area (periportal halo sign; n = 23), striated thickening of the gallbladder wall (n = 27), hyperechoic thickening of the Glisson capsule (n = 11), liver areas of increased echogenicity (n = 11), subcapsular hematoma (n = 1), and subcapsular calcification (n = 1). Probe compression of the liver enhanced abdominal pain (n = 13), whereas the gallbladder was painless in all cases. No gallbladder stones were detected. Ascites (n = 16) and pleural effusion (n = 11) were also present. In no case did we detect abnormalities of the pancreas, kidneys, or spleen. All patients eventually had hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome according to the American College of Obstetricians and Gynecologists classification. In 7 cases, HELLP syndrome developed postpartum. Three patients also had eclampsia. Follow-up sonograms highlighted quick regression of abnormalities after delivery.
  
  
  CONCLUSIONS
  The livers of women with severe preeclampsia who had HELLP syndrome showed sonographic abnormalities before biological abnormalities. Serial sonographic examinations could therefore contribute to the obstetric care of these women. Preeclampsia and HELLP syndrome should be routinely checked for in all pregnant women with acute abdominal pain.
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging*; D015746:Abdominal Pain / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D005260:Female; D017359:HELLP Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000201:enzymology; D006801:Humans; D006984:Hypertrophy; D008099:Liver / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000473:pathology; D011247:Pregnancy; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers