Testicular toxicity effects of magnetic field exposure and prophylactic role of coenzyme Q10 and L-carnitine in mice.
The protective effect of L-carnitine or coenzyme Q10 (CoQ10) against high magnetic field (20 mT) induced testicular toxicity in mice were evaluated. Animals were injected with L-carnitine (200 mg kg(-1), i.p.) or CoQ10 (200 mg kg(-1), p.o.) 1h before exposure to fractionated doses (30 min per day, three times per week for 2 weeks) or acute dose (3h) of magnetic field. Total sperm count, motility, daily sperm production, and testicular LDH-X activity as well as histopathological examination were investigated. Exposure of mice to fractionated doses of magnetic field caused a significant decrease in sperm count, motility, daily sperm production, and LDH-X activity, which was more pronounced than that of acute dose. Moreover, a marked testicular histopathological changes were observed after exposure to fractionated doses of magnetic field. Pretreatment of mice with L-carnitine or CoQ10 1h before exposure to magnetic field caused a significant recovery of mice testes damage induced by high magnetic field (20 mT).
D000465:Algorithms; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002331:Carnitine / Q000627:therapeutic use*; D003067:Coenzymes; D004574:Electromagnetic Fields / Q000009:adverse effects*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007985:Leydig Cells / Q000473:pathology / Q000528:radiation effects; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012671:Seminiferous Tubules / Q000473:pathology / Q000528:radiation effects; D013076:Sperm Count; D013090:Spermatocytes / Q000473:pathology / Q000528:radiation effects; D013093:Spermatogonia / Q000473:pathology / Q000528:radiation effects; D013737:Testis / Q000473:pathology / Q000528:radiation effects*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000975:Antioxidants; D003067:Coenzymes; D011837:Radiation-Protective Agents; D014451:Ubiquinone; D007770:L-Lactate Dehydrogenase; C024989:coenzyme Q10; D002331:Carnitine