[Treatment of tics in Tourette syndrome with atypical antipsychotic drugs].
We reviewed articles in English dealing with research into the effect of atypical antipsychotic drugs on tic reduction in Tourette's syndrome. In Denmark, there are four registered atypical antipsychotic drugs; clozapine, sulpiride, olanzapine, and risperidone. The topic of interest is the effectiveness and side effects of these drugs as compared to the conventional antipsychotic, pimozide, which is today the preferred pharmacological treatment of Tourette's syndrome among the antipsychotics. The conclusion is that risperidone would be a good first-line antipsychotic drug for the treatment of Tourette's syndrome. It is as effective as pimozide, its side effect profile is overall much more favourable, and unlike pimozide it does not contain the risk of causing heart arrhythmia.
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D003024:Clozapine / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000627:therapeutic use; D018967:Risperidone / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013469:Sulpiride / Q000627:therapeutic use; D020323:Tics / Q000188:drug therapy*; D005879:Tourette Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D003024:Clozapine; D018492:Dopamine Antagonists; D000077152:Olanzapine; D010890:Pirenzepine; D018967:Risperidone; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D013469:Sulpiride
Behandling af tics ved Tourettes syndrom med atypiske antipsykotika.