Genetic differences in immune reactions to radiation exposure in humans and experimental animals.
Examination of populations living in regions of fallout radiation revealed changes in the distribution of HLA genes not only in irradiated individuals, but also in their children and grandchildren. Combined irradiation of inbred mice in comparable doses showed that H-2 genes determine immune reactions in animals and their offspring to radiation. Our results indicate that the immune system in mammals is immunogenetically regulated by low-dose radiation.
D000818:Animals; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011832:Radiation Injuries / Q000276:immunology*; D011833:Radiation Injuries, Experimental / Q000276:immunology*
D006680:HLA Antigens