In vitro assessment of the interaction mechanisms between mucin and a cationic cellulosic derivative by rheological methods using an experimental design.
An oscillatory rheological method is used for the determination of the mucoadhesive properties of a cationic cellulosic derivative (JR-30M) proposed for ocular dosage forms and dry eye viscous solutions. An experimental design was set up to study the influence of the concentrations of the polymer and mucin on mucoadhesion. From the rheological data it can be deduced that the interactions between mucin and JR-30M are mainly based on physical entanglements and less on ionic interactions.
D000269:Adhesives; D002412:Cations; D002482:Cellulose / Q000737:chemistry*; D015352:Dry Eye Syndromes / Q000188:drug therapy; D004548:Elasticity; D009077:Mucins / Q000737:chemistry*; D009883:Ophthalmic Solutions; D019999:Pharmaceutical Solutions; D011108:Polymers; D012212:Rheology
D000269:Adhesives; D002412:Cations; D009077:Mucins; D009883:Ophthalmic Solutions; D019999:Pharmaceutical Solutions; D011108:Polymers; D002482:Cellulose