[Effect of isosorbide mononitrate on hypotensive action of enalapril in patients with mild and moderate hypertension].
The aim of the study was to compare hypotensive reaction after treatment with enalapril and enalapril with isosorbide mononitrate in patients with mild and moderate hypertension. Investigations were carried out in 49 patients. In every patient at baseline and after 3 hours from oral administration of enalapril or enalapril and isosorbide mononitrate plasma renin activity, plasma angiotensin converting enzyme activity, plasma aldosterone concentration and blood pressure were estimated. All measurements were repeated after 7 days of treatment. Adding a nitric oxide donor--isosorbide mononitrate--to enalapril does not enhance decrease in blood pressure nor influence plasma renin activity, plasma ACE activity nor plasma aldosterone concentration in patients with mild and moderate hypertension.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D020030:Nitric Oxide Donors / Q000008:administration & dosage / Q000494:pharmacology*; D012083:Renin / Q000097:blood; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D020030:Nitric Oxide Donors; D000450:Aldosterone; D004656:Enalapril; D012083:Renin; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
Wpływ monoazotanu izosorbidu na reakcje hipotensyjna po enalaprilu u chorych na pierwotne nadciśnienie tetnicze łagodne i umiarkowane.