title: Regulation of the activity of Sp1-related transcription factors.
abstract: The initiation of transcription is accomplished via interactions of many different proteins with common and gene-specific regulatory motifs. Clearly, sequence-specific transcription factors play a crucial role in the specificity of transcription initiation. A group of sequence-specific DNA-binding proteins, related to the transcription factor Sp1, has been implicated in the regulation of many different genes, since binding sites for these transcription factors (GC/GT boxes) are a recurrent motif in regulatory sequences such as promoters, enhancers and CpG islands of these genes. The simultaneous occurrence of several homologous GC/GT box-binding factors precludes a straightforward deduction of their role in transcriptional regulation. In this review, we focus on the connection between functional specificity and biochemical properties including glycosylation, phosphorylation and acetylation of Sp1-related factors.
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D016329:Sp1 Transcription Factor / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology
chemical_list: D016329:Sp1 Transcription Factor; D014157:Transcription Factors