Allelic frequency of the MCP-1 promoter -2518 polymorphism in the Korean population and in Korean patients with rheumatoid arthritis, systemic lupus erythematosus and adult-onset Still's disease.
The frequency of the monocyte chemoattractant protein-1 (MCP-1) -2518 G-type polymorphism in Koreans is significantly higher than the frequencies reported for Caucasians and Afro-Americans. The G- vs. A-allele profile in patients with systemic autoimmune diseases is similar to that in healthy Koreans, and does not appear to contribute to elevated MCP-1 production in patients.
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D018932:Chemokine CCL2 / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D005787:Gene Frequency; D006801:Humans; D007723:Korea; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D016706:Still's Disease, Adult-Onset / Q000235:genetics*
D018932:Chemokine CCL2