A battle for survival: immune control and immune evasion in murine gamma-herpesvirus-68 infection.
CD8(+) T cells are generally considered a key defence against herpesviruses. The murine gamma-herpesvirus-68 encodes two proteins that limit their efficacy. M3 neutralizes chemokines, while K3 downregulates MHC class I glycoproteins. The consequence of this evasion is that CD4(+) T cells are essential to the control of persistent infection.
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005805:Genes, MHC Class I / Q000235:genetics; D006566:Herpesviridae Infections / Q000276:immunology* / Q000473:pathology; D007371:Interferon-gamma / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D018144:Rhadinovirus / Q000276:immunology / Q000472:pathogenicity*; D014412:Tumor Virus Infections / Q000276:immunology* / Q000473:pathology; D017735:Virus Latency / Q000276:immunology / Q000502:physiology
D007371:Interferon-gamma