title: Genetics of primary generalized osteoarthritis.
abstract: Osteoarthritis (OA) is a common joint disease with complex etiology, including biomechanical, biochemical, and genetic components. The genetics of primary idiopathic OA is likely complex as multiple susceptibility loci have been identified from genome-wide scans. The future lies in finer mapping of these chromosomal regions, association studies, and candidate gene analysis and identification, which should collectively give rise to an improved understanding of the genetic mutations and biological pathways which increase the risk of developing this common joint disorder.
mesh_terms: D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000235:genetics*