Gestodene: clinical experience with an innovative progestogen used in a combination oral contraceptive preparation.
The contraceptive efficacy, tolerance, and safety of a new monophasic oral contraceptive that combines 75 mcg gestodene (delta-15- levonorgestrel) and 30 mcg ethinyl estradiol were studied in 75 women (944 cycles) currently at risk for pregnancy.  20 women were nulliparous.  No woman became pregnant during the trial, nor were vital signs of body weight affected by the drug.  Cycle control was excellent, with no bleeding irregularities in 92% of the cycles.  Serious complications did not occur.  The low incidence of side effects, e.g.  headache (9%) and breast tenderness (8%), indicated that the gestodene combination was well-tolerated.  In a subgroup of 10 women, no changes in routine laboratory tests could be demonstrated after 12 cycles of treatment.
D001530:Belgium; D001695:Biology; D001769:Blood; D001794:Blood Pressure; D001835:Body Weight; D003267:Contraception; D003268:Contraception Behavior; D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D003625:Data Collection; D019049:Developed Countries; D004997:Ethinyl Estradiol; D005060:Europe; D005193:Family Planning Services; D015994:Incidence; D016912:Levonorgestrel; D008597:Menstrual Cycle; D008598:Menstruation; D010342:Patient Acceptance of Health Care; D010827:Physiology; D012098:Reproduction; D012106:Research; D012107:Research Design
D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D004997:Ethinyl Estradiol; D016912:Levonorgestrel
Belgium; Biology; Blood Pressure--changes; Body Weight--changes; Clinical Research; Contraception; Contraceptive Agents, Estrogen--administraction and dosage; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents--administraction and dosage; Contraceptive Methods--side effects; Contraceptive Usage; Data Collection; Developed Countries; Ethinyl Estradiol--administraction and dosage; Europe; Family Planning; Hemic System; Incidence; Levonorgestrel--administraction and dosage; Measurement; Menstrual Cycle; Menstruation; Method Acceptability; Oral Contraceptives, Combined--side effects; Oral Contraceptives--side effects; Physiology; Reproduction; Research Methodology; Western Europe