title: The association between birth weight and capillary recruitment is independent of blood pressure and insulin sensitivity: a study in prepubertal children.
abstract: OBJECTIVE
  Alterations in microvascular function have been hypothesized as a possible mechanism explaining the negative association of weight at birth with blood pressure and insulin resistance in adult life. However, these variables are closely associated, so that it has been difficult to establish whether microvascular dysfunction is a cause or a consequence of increased blood pressure or insulin resistance.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  VU University Medical Center, Amsterdam, The Netherlands.
  
  
  METHODS
  Twenty-one prepubertal healthy children showing a wide range in birth weight.
  
  
  METHODS
  Birth weight data were obtained from hospital records. Blood pressure was measured with an ambulatory 24-h blood pressure monitor, and insulin sensitivity was assessed with the hyperinsulinaemic euglycaemic clamp technique. Microvascular function (i.e. capillary recruitment during post-occlusive reactive hyperaemia and endothelium (in)dependent vasodilatation of the skin) was evaluated by videomicroscopy and iontophoresis of acetylcholine and sodium nitroprusside.
  
  
  RESULTS
  Birth weight was positively and significantly associated with capillary recruitment [slope, 22%/kg birth weight; 95% confidence interval (CI), 0.1-43; 0.05]. Birth weight was not associated with insulin sensitivity and systolic blood pressure (slope, -0.11 mg/kg per min per pmol/l; 95% CI, -2.4 to 2.2; = 0.9; and slope, 1.4 mmHg; 95% CI, -5.0 to 7.7/kg birth weight; = 0.7, respectively). The association between low birth weight and impaired capillary recruitment was not affected by adjustment for blood pressure and insulin sensitivity. Birth weight was not associated with endothelium-(in)dependent vasodilatation.
  
  
  CONCLUSIONS
  These results suggest that the association between birth weight and capillary recruitment is independent of blood pressure and insulin sensitivity. These findings are consistent with the hypothesis that an impaired capillary recruitment plays a mechanistic role in the association of birth weight with blood pressure and insulin resistance in adult life.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D001724:Birth Weight / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D001824:Body Constitution; D015992:Body Mass Index; D002196:Capillaries / Q000502:physiology*; D002648:Child; D002669:Child Welfare; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005260:Female; D005865:Gestational Age; D015309:Glucose Clamp Technique; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000098:blood supply / Q000502:physiology; D009426:Netherlands; D009599:Nitroprusside / Q000494:pharmacology; D011627:Puberty / Q000502:physiology*; D012016:Reference Values; D013223:Statistics as Topic; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine