[The ratio of components of sphingomyelin cycle and lipid composition in patients with viral hepatitis].
The aim of the study is the investigation of the content of the lipids and the sphingomyelin cycle components in the liver of the patients suffered from viral hepatitis. The methods used were thin layer chromatography for the detection of the lipid pattern and gas liquid chromatography for evaluation of the sphingomyelin fatty acid's and spectrum and ceramides. In the patients suffered from viral hepatitis HCV with moderate activity of the process cholesterin and triglycerides level were less and lysophospholipids content was two-fold and sphingomyelin level was insignificantly higher comparingly than in patients with low activity of the process. In the group of patients suffered from mixt infection (HCV + HBV) there is decreased cholesterin and both phosphatidylcholin and the sphingomyelin content along with lysophospholipids level elevation. In the fatty acid spectrum the palmitate acid (16:0) and the long chain acids (C22-C24) content were higher comparingly with ceramides. Significant difference is observed in oleic acid (18:1) content being as small as 9.3-9.9% in the liver damaged by viral hepatitis.
D000328:Adult; D002518:Ceramides / Q000097:blood*; D006509:Hepatitis B / Q000097:blood* / Q000150:complications; D006526:Hepatitis C / Q000097:blood* / Q000150:complications; D006801:Humans; D008055:Lipids / Q000097:blood*; D013109:Sphingomyelins / Q000097:blood*
D002518:Ceramides; D008055:Lipids; D013109:Sphingomyelins
Sootnoshenie komponentov sfingomielinovogo tsikla i sostav lipidov u bol'nykh virusnym gepatitom.