Role of lipoproteins transporting lipophilic xenobiotics in the induction of microsomal monooxygenases.
We studied the effects of lipopolysaccharide on activity of liver microsomal enzymes against the background of xenobiotics treatment. Against the background of lipopolysaccharide stimulation of macrophages we observed in vivo activation of cytochromes P-450 1A subfamily in liver microsomes with Arochlor 1254, but not induction of cytochrome P-450 2B subfamily with phenobarbital.
D000818:Animals; D008074:Lipoproteins / Q000502:physiology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D015262:Xenobiotics / Q000378:metabolism* / Q000494:pharmacology
D008074:Lipoproteins; D015262:Xenobiotics; D006899:Mixed Function Oxygenases