Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration.
The objective of this study was to determine the pharmacokinetic behaviour of imidocarb in horses following a single i.m. injection at the dose commonly administered to treat Babesia caballi infections or to prevent babesiosis. Eight horses were injected i.m. with a single dose of 2.4 mg imidocarb dipropionate/kg bwt and blood, faecal, urine and milk samples were collected. For imidocarb determination, a high-performance liquid chromatographic method (HPLC) was used after weak cation-exchange solid phase, or liquid-liquid, extraction procedures. Twelve hours after treatment, no detectable plasma concentrations were recorded in any of the treated animals. The distribution and elimination patterns of the drug suggested that it is quickly sequestrated in some storage tissues and remains in the body for a long time. Its prolonged presence in the body may confer a reservoir effect to imidocarb in some tissues, therefore making it undetectable in the plasma of animals but sufficient to produce its described therapeutic and prophylactic activities.
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001404:Babesiosis / Q000188:drug therapy / Q000662:veterinary; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000662:veterinary; D005243:Feces / Q000737:chemistry; D005260:Female; D006207:Half-Life; D006734:Horse Diseases / Q000188:drug therapy; D006736:Horses / Q000378:metabolism*; D007095:Imidocarb / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D008657:Metabolic Clearance Rate; D008892:Milk / Q000737:chemistry; D014018:Tissue Distribution; D016482:Urinalysis / Q000662:veterinary
D000981:Antiprotozoal Agents; D007095:Imidocarb; C031719:imidocarb dipropionate