[Treatment of cancer in women and fertility preservation].
The progress observed in the treatment of cancer have increased the survival rate of patients. Therefore, the different aspects of quality of life are considered as more and more important. Fertility is one of the major concern of women surviving cancer. Chemotherapy and radiotherapy can alter gametes and reproductive function. For some patients, a method to preserve fertility potential can be proposed. In the patient who have a partner, embryo freezing is the most reliable method, but give a limited chance of pregnancy. Recent interesting data has been obtained with oocyte freezing but the teams succeeding in the method and the number of pregnancies obtained remains limited. Moreover these methods request the time to perform ovarian stimulation. Freezing of ovarian tissue is giving us lots of hopes. Ovarian stimulation is not necessary and allow the conservation of a large number of eggs. However it is requesting a surgical procedure and no pregnancy was obtained so far in the human species. If the different methods to preverve fertility were not possible to propose or failed, oocyte donation give a good chance of success. It is important to state that no matter which method is used, the success rate will be correlated to the integrity of the uterus which can be altered by the different treatments of cancer and especially by radiotherapy. Collaboration between the teams of oncology and reproductive medicine is a progress in the management of young cancer patients. The technical progress in the technique of ovarian tissue freezing and in vitro maturation of follicle could be determinant in the choices proposed to the patients.
D015925:Cryopreservation / Q000379:methods*; D004622:Embryo, Mammalian; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D010053:Ovary; D010063:Ovum
Traitement du cancer chez la femme et préservation de la fertilité.