SP-D as a marker of amiodarone-induced pulmonary toxicity.
Two patients with amiodarone-induced pulmonary toxicity (APT) showed abnormally increased serum SP-D concentrations, although their KL-6 level was within the normal range. In a 59-year-old man with ischemic heart disease, APT progressed rapidly and required steroid pulse therapy. During the clinical course, SP-D was as high as 375 ng/ml, although the KL-6 level was only 289 U/ml. In a 58-year-old man treated for dilated cardiomyopathy, SP-D increased to 289 ng/ml, while KL-6 remained at less than 500 U/ml. These cases indicate that SP-D is a useful and early diagnostic marker for APT even when KL-6 is not elevated.
D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D000941:Antigens / Q000097:blood; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood*; D005938:Glucocorticoids / Q000627:therapeutic use; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects*; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D011663:Pulmonary Surfactants / Q000097:blood*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
D000889:Anti-Arrhythmia Agents; D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D005938:Glucocorticoids; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants; D000638:Amiodarone; D008775:Methylprednisolone