Intracranial hemorrhage in neuro-Behçet's syndrome.
OBJECTIVE
Most cerebrovascular disturbances in Behçet's syndrome are occlusive in nature, while hemorrhage is rare. In this paper, we report three cases of neuro-Behçet's syndrome presenting with intracerebral hemorrhaging, and discuss the possible causes as they relate to cyclosporine treatment.


METHODS
Three cases of neuro-Behçet's syndrome presented with intracranial hemorrhage. One patient had been taking cyclosporine, and the other two patients had never taking cyclosporine.


RESULTS
Together with previous reports, these cases suggest that there are two types of intracranial hemorrhage in neuro-Behçet's syndrome. One type occurs in the center of a lesion and during the acute phase of the disease, while the other occurs in the peripheral lesion and during the subacute phase.


CONCLUSIONS
It appears that the intracranial hemorrhages in neuro-Behçet's syndrome can be divided into two groups. It is possible that the vascular pathologies caused by Behçet's syndrome and by cyclosporine conspire to induce CNS hemorrhaging in some cases.
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D005938:Glucocorticoids; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine