[Autoimmune hepatitis caused by acute hepatitis due to hepatitis A virus].
We describe the case of a 27-year-old man who presented acute hepatitis due to hepatitis A virus infection. Over the following weeks he consistently presented elevated transaminase levels and jaundice. Antinuclear and anti-smooth muscle antibodies, hypergammaglobulinemia and periportal necrosis were detected in the liver biopsy. The patient was diagnosed with autoimmune hepatitis and responded well to treatment with immunosuppressive drugs. This case, as well as other published reports, suggest that in certain individuals, acute hepatitis A may be the decisive factor leading to autoimmune hepatitis.
D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D015415:Biomarkers; D001706:Biopsy; D001782:Blood Donors; D004359:Drug Therapy, Combination; D006506:Hepatitis A / Q000097:blood / Q000150:complications*; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D006942:Hypergammaglobulinemia / Q000209:etiology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D005723:gamma-Glutamyltransferase / Q000097:blood
D001323:Autoantibodies; D015415:Biomarkers; D007166:Immunosuppressive Agents; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001379:Azathioprine; D011241:Prednisone
Hepatitis autoinmune desencadenada por una hepatitis aguda por virus de la hepatitis A.