title: Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse.
abstract: Thyroid hormones have an influence on the connective tissue biology of the skin and, theoretically, topically applied thyroid hormones or hormone analogues could have a stimulatory effect on collagen synthesis. In this investigation the effect of topical tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues were tested for their effect in preventing betamethasone-induced skin atrophy in the normal haired mouse. Triac, tri-iodoproprionic acid (Triprop) and the synthetically developed thyroid hormone analogue KB-026 and 2 different Triac cream formulations were applied along with betamethasone on shaved mouse skin. Triac in daily doses of 1 nmol/cm2 and higher was able to block the betamethasone-induced skin atrophy in mice skin. In high doses, Triprop and KB-026 also had a blocking effect. Triac alone had a stimulatory effect on dermal thickness. This study indicates that thyroid hormone analogues may be used to prevent corticosteroid-induced skin atrophy.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D001284:Atrophy; D001623:Betamethasone / Q000633:toxicity*; D005938:Glucocorticoids; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced / Q000517:prevention & control*; D014284:Triiodothyronine / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D014284:Triiodothyronine; C010642:3,3',5-triiodothyroacetic acid; D001623:Betamethasone