title: Endometriosis results from the dislocation of basal endometrium.
abstract: BACKGROUND
  The hypothesis is tested that both adenomyotic and endometriotic lesions are derived from basal endometrium.
  
  
  METHODS
  Normal uteri and uteri with adenomyosis obtained by hysterectomy, excised endometriotic lesions and menstrual blood of women with and without endometriosis were used. Estrogen receptor (ER), progesterone receptor (PR), progesterone receptor B isoform (PR(B)) and P450 aromatase (P450A) immunohistochemistry was performed with the use of specific monoclonal antibodies.
  
  
  RESULTS
  With respect to the parameters studied there was a fundamental difference between the cyclical patterns of the basalis and the functionalis of the eutopic endometrium. The endometrium of endometriotic and adenomyotic lesions mimicked the cyclical pattern of the basalis. The peristromal muscular tissue of endometriotic and adenomyotic lesions displayed the same cyclical pattern of ER and PR expression as the archimyometrium. There was a significantly higher prevalence of fragments of shed basalis in menstrual blood of women with endometriosis than in healthy controls.
  
  
  CONCLUSIONS
  These data suggest that ectopic endometrial lesions result from dislocation of basal endometrium. Dislocated basal endometrium has stem cell character resulting in the ectopic formation of all archimetrial components such as epithelial and stromal endometrium as well as peristromal muscular tissue.
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001141:Aromatase / Q000032:analysis; D004715:Endometriosis / Q000209:etiology* / Q000473:pathology; D004717:Endometrium / Q000737:chemistry / Q000473:pathology*; D004848:Epithelium / Q000737:chemistry; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008597:Menstrual Cycle; D008598:Menstruation; D008875:Middle Aged; D009130:Muscle, Smooth / Q000737:chemistry; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C097314:progesterone receptor B; D001141:Aromatase