title: The many functions of SMC proteins in chromosome dynamics.
abstract: Members of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.
mesh_terms: D000251:Adenosine Triphosphatases / Q000502:physiology; D000818:Animals; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone; D002875:Chromosomes / Q000502:physiology*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000502:physiology; D004303:Dosage Compensation, Genetic; D005656:Fungal Proteins; D046911:Macromolecular Substances; D008540:Meiosis; D008954:Models, Biological; D046912:Multiprotein Complexes; D009687:Nuclear Proteins / Q000502:physiology; D017434:Protein Structure, Tertiary; D011995:Recombination, Genetic; D000097722:Cohesins
chemical_list: D000251:Adenosine Triphosphatases; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D046911:Macromolecular Substances; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D000097722:Cohesins; C108312:condensin complexes