[Effectiveness of combined treatment in patient with advanced ovarian carcinoma].
OBJECTIVE
The objectives of this study was to evaluate chemotherapy, GnRH analogues and radiotherapy as adjuvant treatment in advanced epithelial ovarian carcinoma.


METHODS
It was a retrospective analysis. 69 patients with stage III and IV epithelial ovarian carcinoma after maximal debulking surgery received adjuvant chemotherapy with cyclophosphamide and cisplatin or carboplatin (6-9 course). Additionally some of them were treated with radiotherapy or/and GnRH agonists. In relation to treatment patients were divided into 4 groups: I--received chemotherapy + GnRH agonist + radiotherapy, II--chemotherapy + GnRH agonist, III--chemotherapy + radiotherapy and IV--chemotherapy. Statistical analysis was based on nonparametric U-Mann-Whitney test. Survival analysis performed with Kaplan-Meyer method.


RESULTS
We found statistical differences in overall survival, 5-years survival and overall complete response rate between the group treated with only chemotherapy and groups the also received radiotherapy or/and GnRH analogues.


CONCLUSIONS
Combination treatment in advanced epithelial ovarian cancer seems to be a reasonable way of therapeutic management. Radiotherapy and GnRH agonists with chemotherapy are effective consolidation therapy for stage III and IV ovarian cancer.
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013997:Time Factors
D003520:Cyclophosphamide; D016190:Carboplatin; D002945:Cisplatin
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