title: Synthesis, surface properties and performance of thiosulphate-substituted plasticized poly(vinyl chloride).
abstract: Plasticized poly(vinyl chloride) (PVC) was surface modified by nucleophilic substitution of the chlorine atoms of PVC by thiosulphate in aqueous media in the presence of a phase-transfer catalyst. The properties of the modified surface were evaluated by contact angle measurements, attenuated total reflection Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy. Migration of the plasticizer di-(2-ethylhexyl) phthalate from control as well as modified PVC was examined in hexane, in cottonseed oil and in poly(ethylene glycol)-400 (PEG-400). While the modified PVC was found to be highly migration resistant in hexane, cottonseed oil and PEG-400 extracted the plasticizer. The modified PVC was found to cause haemolysis and was cytotoxic. A possible explanation for the difference in performance of the modified material in different extraction media and its toxicity is presented from a mechanistic view of the substitution process.
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002465:Cell Movement; D004577:Electron Probe Microanalysis; D006461:Hemolysis; D008855:Microscopy, Electron, Scanning; D010969:Plastics / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry*; D011817:Rabbits; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013455:Sulfur / Q000378:metabolism; D013885:Thiosulfates / Q000737:chemistry*; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D010969:Plastics; D013885:Thiosulfates; D013455:Sulfur; D011143:Polyvinyl Chloride