False-reactive test for hepatitis B surface antigen following administration of granulocyte-colony-stimulating factor.
OBJECTIVE
High-dose granulocyte transfusions are being administered to severely granulocytopenic patients. A single dose of G-CSF is given to donors for mobilization of granulocytes prior to donation.


METHODS
Infectious disease tests were performed on a donor before and after G-CSF was given.


RESULTS
Hepatitis B surface antigen (HBsAg) testing was transiently reactive following administration of G-CSF when examined using a test kit from one manufacturer, but not another. No other cause was found.


CONCLUSIONS
A false-reactive test for HBsAg using one manufacturer's test kit can occur following a single dose of G-CSF.
D000328:Adult; D016913:Blood Component Transfusion; D001782:Blood Donors; D005188:False Negative Reactions; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006098:Granulocytes; D006509:Hepatitis B / Q000175:diagnosis*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000592:standards; D008297:Male; D011933:Reagent Kits, Diagnostic; D012698:Serologic Tests / Q000592:standards
D006514:Hepatitis B Surface Antigens; D011933:Reagent Kits, Diagnostic; D016179:Granulocyte Colony-Stimulating Factor