Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains.
Despite its initial identification in neurons exposed to the seizure-inducing drug pentylentetrazole (PTZ), the function of the seizure-related gene SEZ-6 remains obscure. Expression analysis indicates specific expression in the adult brain and testis, and the structure of the predicted protein suggests putative roles in cell-cell recognition and signalling. We report here that type I SEZ-6 mRNA is strongly expressed in highly specific regions in the developing forebrain. Specifically, the pattern of SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development. In the adult hippocampus, SEZ-6 appears to be a CA1-specific regional marker.
D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000196:embryology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics*; D016548:Prosencephalon / Q000196:embryology; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000378:metabolism; D012640:Seizures; D015398:Signal Transduction; D013737:Testis / Q000196:embryology; D013997:Time Factors
D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D012333:RNA, Messenger; C093131:Sez6 protein, mouse