Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.
D000818:Animals; D001681:Biological Assay; D002417:Cattle; D002460:Cell Line; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects; D058851:GPI-Linked Proteins; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects; D020439:Growth Cones / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D006801:Humans; D051379:Mice; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000494:pharmacology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D012165:Retinal Ganglion Cells / Q000187:drug effects
D058851:GPI-Linked Proteins; C571326:MOG protein, human; C571327:Mog protein, mouse; C571328:Mog protein, rat; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; C560528:OMG protein, human; C560529:Omg protein, mouse; C560532:Omg protein, rat