title: CIN85/CMS family of adaptor molecules.
abstract: CIN85 and CMS belong to a family of ubiquitously expressed adaptor molecules containing three SH3 domains, a proline-rich region and a coiled-coil domain. By binding to numerous proteins they assemble multimeric complexes implicated in cell-specific signals controlling T-cell activation, kidney glomeruli function or apoptosis in neuronal cells. CIN85/CMS also associate with accessory endocytic proteins, components of the actin cytoskeleton as well as other adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. These interactions enable CIN85/CMS to function within a network of signaling pathways that co-ordinate critical steps involved in downregulation and degradation of RTKs.
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D004705:Endocytosis; D006801:Humans; D007668:Kidney / Q000502:physiology; D011506:Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C114545:CD2-associated protein; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D011506:Proteins; C433810:SH3KBP1 protein, human; D020794:Receptor Protein-Tyrosine Kinases