title: Developmental Issues: Physiologic Factors Affecting the Safety and Bioavailability.
abstract: In this expanded overview, the development of digestive and absorptive function at birth and during the first year of life are reviewed. Concerns regarding these functions in premature will be considered. In addition, nonspecific and specific host immune function in the developing gut are considered in the context of bioavailability of dietary supplements. Having reviewed what is known about these developmental gut functions and their maturation in the first year of life, safety and bioavailability issues and recommendations are considered.