title: Gene expression during the life cycle of Drosophila melanogaster.
abstract: Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.
mesh_terms: D000465:Algorithms; D000818:Animals; D016000:Cluster Analysis; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000254:growth & development*; D004625:Embryo, Nonmammalian / Q000502:physiology; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D005854:Germ Cells / Q000502:physiology; D007814:Larva / Q000235:genetics; D008018:Life Cycle Stages / Q000235:genetics*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D009928:Organ Specificity; D011679:Pupa / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012727:Sex Characteristics; D014158:Transcription, Genetic
chemical_list: D029721:Drosophila Proteins; D012333:RNA, Messenger