Current molecular models for NADPH oxidase regulation by Rac GTPase.
Reactive oxygen species (ROS) have been increasingly recognized as important components of cell signaling in addition to their well-established roles in host defense. The formation of ROS in phagocytic and nonphagocytic cells involves membrane-localized and Rac guanosine triphosphatase (GTPase)-regulated reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase(s). We discuss here the current molecular models for Rac GTPase action in the control of the phagocytic leukocyte NADPH oxidase. As a mechanistically detailed example of Rac GTPase signaling, the NADPH oxidase provides a potential paradigm for signaling by Rho family GTPases in general.
D000818:Animals; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D019255:NADPH Oxidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010586:Phagocytes / Q000201:enzymology; D020744:rac GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
D019255:NADPH Oxidases; D020744:rac GTP-Binding Proteins