title: Salivary cytokine profiles in the immunocompetent individual with Candida-associated denture stomatitis.
abstract: Cell-mediated immunity conferred by CD4+ T helper cells is considered the predominant host defense against mucosal Candida infections, with Thelper (Th1)-type responses associated with resistance to infection and Th2-type responses associated with susceptibility to infection. Oropharyngeal candidiasis, the most common oral opportunistic infection in HIV-infected persons, is associated with a Th2-type cytokine profile in saliva. To obtain more direct evidence for a role of salivary cytokines in susceptibility to oropharyngeal candidiasis during immunosuppression, we evaluated Th1/Th2-type cytokines in the saliva of those with denture stomatitis, a form of oropharyngeal candidiasis not related to immunosuppression. Results showed that HIV-negative denture wearers with and without denture stomatitis demonstrated a mixed Th1/Th2 cytokine profile with no significant differences found between the groups. These results suggest that a local Th cytokine dichotomy in saliva is not associated with susceptibility to denture stomatitis in immunocompetent persons.
mesh_terms: D000328:Adult; D000368:Aged; D002176:Candida albicans / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000276:immunology*; D016207:Cytokines / Q000032:analysis*; D003824:Denture, Complete / Q000382:microbiology; D003829:Denture, Partial / Q000382:microbiology; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007121:Immunocompetence / Q000276:immunology*; D007371:Interferon-gamma / Q000032:analysis; D016753:Interleukin-10 / Q000032:analysis; D018664:Interleukin-12 / Q000032:analysis; D007376:Interleukin-2 / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000276:immunology*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D018709:Statistics, Nonparametric; D013282:Stomatitis, Denture / Q000276:immunology / Q000382:microbiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D012471:Salivary Proteins and Peptides; D016753:Interleukin-10; D018664:Interleukin-12; D015847:Interleukin-4; D007371:Interferon-gamma