title: Biosynthesis of hyperforin in Hypericum perforatum.
abstract: Cut sprouts of Hypericum perforatum were proffered solutions containing [1-(13)C]glucose or [U-(13)C(6)]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties, which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway. The phloroglucinol moiety is generated via a polyketide type mechanism.
mesh_terms: D001643:Bridged Bicyclo Compounds; D020902:Hypericum / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives; D013729:Terpenes / Q000378:metabolism*
chemical_list: D001643:Bridged Bicyclo Compounds; D013729:Terpenes; D010696:Phloroglucinol; C001654:hyperforin