title: [A case of effective antithrombotic therapy for cerebral infarction presenting long-lasting fluctuation of symptoms].
abstract: We report a 78-year-old female presenting fluctuation of cerebral ischemic symptoms for a long time. Three weeks after transient ischemic attack of speech disturbance, she suffered right hemiparesis and motor dominant aphasia. The symptoms gradually progressed. Magnetic resonance angiography (MRA) showed a stenosis of branches of the left middle cerebral artery and single photon emission computed tomography (SPECT) did hypoperfusion of the same artery territory. Though antiplatelet and anticoagulant therapy was continued, the symptoms fluctuated. After 5 months, she recovered to mild deficit and MRI finally showed no responsible infarcted area. The pathophysiology of this course was considered to be progressing stroke based on a stenosis of the middle cerebral artery and the atrial fibrillation. Early diagnosis and treatment for cerebral ischemia may lead to the recovery from fluctuating symptoms.
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000503:physiopathology* / Q000523:psychology; D002560:Cerebrovascular Circulation; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors