Simultaneous N7,O6-binding of guanine to two zinc centers and its possible biological significance.
The reaction of ZnCl(2) with 9-ethylguanine (9-EtGH) produced a novel dinuclear Zn(II) complex, [Zn(2)Cl(4)(H(2)O)(mu-9-EtGH-N7,O6)(9-EtGH-N7), 1. The X-ray structure analysis (monoclinic, P2(1) (No. 4), a = 11.0636(6) A, b = 6.6546(4) A, c = 15.9630(9) A, beta = 101.069(1) degrees, V = 1153.4(1) A(3), Z = 2) revealed that one of the tetrahedrally coordinated Zn(II) atoms binds to the N7 site of 9-EtGH and to the exocyclic O6 atom of another 9-EtGH molecule. The remaining Zn(II) atom binds to the N7 site of the second 9-EtGH moiety.
D001665:Binding Sites; D002712:Chlorides / Q000737:chemistry; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry
D002712:Chlorides; D009942:Organometallic Compounds; D017967:Zinc Compounds; D006147:Guanine; C016837:zinc chloride; C014542:9-ethylguanine; D004247:DNA; D015032:Zinc; D009584:Nitrogen; D010100:Oxygen