The diagnosis and treatment of hairy-cell leukaemia.
The diagnosis of HCL is usually straightforward and is based on the identification of typical HCs in the blood and bone marrow. The suspected diagnosis is confirmed by a combination of TRAP cytochemistry, a distinctive immunophenotype and characteristic BM trephine appearances. Nucleoside treatment is highly effective in inducing prolonged remissions; relapsing patients can usually be successfully retreated with nucleoside. Monoclonal antibody therapy is a promising novel approach to the treatment of resistant disease.
D001856:Bone Marrow Examination; D006651:Histocytochemistry; D006801:Humans; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D011684:Purine Nucleosides / Q000627:therapeutic use; D012074:Remission Induction / Q000379:methods
D011684:Purine Nucleosides