title: Selective regulation of acid, pepsinogen, and bicarbonate secretion in the stomach by different C-fiber populations of vagus nerve.
abstract: Acute experiments on anesthetized rats showed that group B nerve fibers of the subphrenic portion of the vagus nerve do not participate in the regulation of gastric secretion. Gastric acid production is mainly controlled by fast C-fibers (2.11 0.09 m/sec), while secretion of pepsinogen and bicarbonates depends on activity of both fast and slow (0.95 0.11 m/sec) C-fibers. Some fast conduction C-fibers stimulating the release of bicarbonates in the stomach are capsaicin-sensitive afferents. The local effect of these afferents depends on cholinergic transmission and most probably it is mediated via its modulation.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001639:Bicarbonates / Q000378:metabolism*; D002211:Capsaicin / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D020116:Pepsinogen A / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000294:innervation / Q000502:physiology*; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
chemical_list: D001639:Bicarbonates; D001285:Atropine; D020116:Pepsinogen A; D002211:Capsaicin