[Placebo-controlled study of short-term hypotensive effect of intranasal ventilation with continuous positive pressure upper respiratory tract therapy in patients with stage I arterial hypertension].
OBJECTIVE
To compare a short-term hypotensive effect of intranasal ventilation with continuous positive airway pressure (CPAP-therapy) in patients with arterial hypertension stage I and placebo-control patients.


METHODS
The CPAP-therapy and placebo-control groups consisted of 12 young men with arterial hypertension (AH) stage I. They were matched by age, body mass index, smoking habits, arterial pressure 24-h monitoring (APM) and night cardiorespiratory monitoring. Patients of the treatment group received CPAP-therapy (REMstar Choice, Respironics, USA) followed by repeated APM. Patients of the placebo group used a nasal mask without turning on the apparatus. Then a repeated APM was performed.


RESULTS
As shown by improved APM data, CPAP-therapy was effective in AH stage I. Positive response was the greatest for systolic and diastolic hypertensive load.


CONCLUSIONS
The above results may serve as an argument in support of a positive relation between elevated resistance of the upper respiratory airways in sleep and systemic AH.
D000293:Adolescent; D000328:Adult; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D008297:Male; D010919:Placebos; D011175:Positive-Pressure Respiration
D010919:Placebos
Placebo-kontroliruemoe issledovanie kratkosrochnogo gipotenzivnogo éffekta intranazal'noĭ ventiliatsii s postoiannym polozhitel'nym davleniem v verkhnikh dykhatel'nykh putiakh u bol'nykh arterialnoĭ gipertonieĭ I stadii.