title: Non peptidic ligands at the opioid receptor like-1 (ORL-1).
abstract: Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases. This review deals with non peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D011957:Receptors, Opioid / Q000737:chemistry / Q000187:drug effects*; D000094942:Nociceptin Receptor
chemical_list: D008024:Ligands; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; C000722283:OPRL1 protein, human