Axon targeting meets protein trafficking: Comm takes Robo to the cleaners.
Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway.
D000818:Animals; D001369:Axons / Q000502:physiology*; D002450:Cell Communication / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D004330:Drosophila / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000502:physiology; D011992:Endosomes / Q000235:genetics / Q000378:metabolism; D007839:Functional Laterality / Q000235:genetics; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D008024:Ligands; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D000097905:Roundabout Proteins
D029721:Drosophila Proteins; D008024:Ligands; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C110665:comm protein, Drosophila; C066819:sli protein, Drosophila