Effect of oral contraceptive use on the erythrocytic glutathione reductase and aspartate aminotransferase activities in women with or without clinical signs of vitamin deficiency.
The effect of the chronic use of combined oral contraceptives (OCs) on the "activity coefficients" (alpha = coenzyme-stimulated activity/basal activity) of erythrocytic glutathione reductase and aspartate aminotransferase was studied in 2 groups of 90 female volunteers each; 1 of the groups, from the state of Yucatan in southeast Mexico, presented clinical lesions of vitamin deficiency, while the other group, from Mexico City, did not have any clinical evidence of vitamin deficiency.  One half of the women (45) in each group were chronic OC users and the other half were not.  The results were analyzed comparing OC users with non-users in each location.  For both glutathione reductase and aspartate aminotransferase, the Mexico City OC users had significantly higher (p  0.001) alpha values than nonusers, while in the Yucatan women, the alpha values were similarly high independent of OC use.
D000569:Americas; D003267:Contraception; D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D003677:Deficiency Diseases; D003906:Developing Countries; D004194:Disease; D005193:Family Planning Services; D007843:Latin America; D008800:Mexico; D009656:North America; D009748:Nutrition Disorders; D012106:Research
D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral
Americas; Comparative Studies; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents--side effects; Contraceptive Methods--side effects; Deficiency Diseases; Developing Countries; Diseases; Family Planning; Latin America; Mexico; North America; Nutrition Disorders; Oral Contraceptives--side effects; Research Methodology; Studies