Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes.
Beyond the already known aetiopathogenic factors linked to periventricular leukomalacia, a major pathological substrate in cerebral palsy, immune-inflammatory mechanisms have recently been implicated. Thus proinflammatory cytokines have been shown to be involved very early in the course of this disorder. Additionally, markers of T-lymphocyte activation were upregulated. These findings provide new insight into mechanisms underlying neural cell death in this condition and might open new horizons for preventive and therapeutic strategies.
D001921:Brain / Q000378:metabolism / Q000473:pathology; D002547:Cerebral Palsy / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000276:immunology / Q000378:metabolism; D012307:Risk Factors; D013601:T-Lymphocytes / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha