title: Effect of microcrystalline chitosan on the solubility of ibuprofen.
abstract: It was found that MCCh may be used for the enhancement of the solubility and dissolution rates of drugs. The solubility of IBA in water increased significantly (about 10-fold) when MCCh was added. Differential scanning calorimetry (DSC), powder X-ray diffractometry, and IR spectroscopy were used to confirm that salt links between the drug and MCCh occurred.
mesh_terms: D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry*; D012995:Solubility / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D002686:Chitin; D048271:Chitosan; D007052:Ibuprofen