title: Axon targeting meets protein trafficking: Comm takes Robo to the cleaners.
abstract: Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway.
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002450:Cell Communication / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D004330:Drosophila / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000502:physiology; D011992:Endosomes / Q000235:genetics / Q000378:metabolism; D007839:Functional Laterality / Q000235:genetics; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D008024:Ligands; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D000097905:Roundabout Proteins
chemical_list: D029721:Drosophila Proteins; D008024:Ligands; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C110665:comm protein, Drosophila; C066819:sli protein, Drosophila