title: Chemical analysis of human skin emanations: comparison of volatiles from humans that differ in attraction of Aedes aegypti (Diptera: Culicidae).
abstract: Host odors are believed to play a major role in the location of blood meals by female mosquitoes. Previous work has shown that female Aedes aegypti (L.) are attracted to a residuum of skin emanations deposited on glass. The attraction of mosquitoes to handled or rubbed glass varies from person to person and from day to day. This variation indicates that mosquito behavior varies over time and that a relative difference exists in the ability of people over time to attract mosquitoes. Volatiles desorbed from glass handled by 2 human subjects that differed markedly in their attraction of Ae. aegypti were examined for differences in compound abundances. The attractive emanations, once deposited onto glass, are known to have a finite lifetime; therefore, compounds that decreased substantially during aging of handled glass also were noted. A study was conducted on the variations in compounds present from a single subject, which were recorded over a 5-day period. Emanations from the subject were transferred to glass, then thermally desorbed from the glass, and compounds present were compared on the 2 consecutive days that showed the largest difference in attraction. Some of the candidate attractants identified by these studies were screened in an olfactometer. A few of these compounds were found to be weak attractants for Ae. aegypti.
mesh_terms: D000330:Aedes / Q000502:physiology*; D000818:Animals; D005990:Glycerol / Q000032:analysis; D006801:Humans; D007299:Insect Bites and Stings / Q000503:physiopathology*; D007659:Ketones / Q000032:analysis; D019344:Lactic Acid / Q000032:analysis; D009812:Odorants; D012867:Skin / Q000737:chemistry / Q000469:parasitology*; D012879:Skin Physiological Phenomena; D013185:Squalene / Q000032:analysis
chemical_list: D007659:Ketones; D019344:Lactic Acid; D013185:Squalene; D005990:Glycerol