title: Iron acquisition by Gram-positive bacterial pathogens.
abstract: For the majority of bacterial pathogens, acquisition of iron from host proteins is a prerequisite for growth during infection. The mechanisms by which Gram-negative bacteria obtain iron from host proteins have been well described, but only recently has substantial progress been made in identifying these mechanisms for Gram-positive bacterial pathogens. This review provides an overview of the existing knowledge on the genetic basis of iron transport for important Gram-positive pathogens.
mesh_terms: D001692:Biological Transport; D003353:Corynebacterium diphtheriae / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006094:Gram-Positive Bacteria / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D016908:Gram-Positive Bacterial Infections / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008089:Listeria monocytogenes / Q000378:metabolism; D013210:Staphylococcus / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000378:metabolism; D013297:Streptococcus pyogenes / Q000378:metabolism
chemical_list: D007501:Iron