The determination of levofloxacin by flow injection analysis using UV detection, potentiometry, and conductometry in pharmaceutical preparations.
A flow injection analysis (FIA) using UV detection, potentiometry and conductometry for levofloxacin (LVF) are described in this study. The best solvent system was found to consist of 0.2 M acetate buffer at pH 3 having 10% MeOH. A flow rate of 1 ml min(-1) was pumped and active material was detected at 288 nm. The detection limit (LOD) and limit of quantification (LOQ) for FIA were calculated to be 3 x 10(-7) M (S/N = 3) and 1 x 10(-7) M (S/N = 10), respectively. In the analysis of tablets, the RSD values were found to be 0.83, 0.98 and 0.99 for FIA, potentiometric and conductometric methods, respectively.
D003217:Conductometry / Q000379:methods; D017022:Flow Injection Analysis / Q000379:methods; D064704:Levofloxacin; D015242:Ofloxacin / Q000032:analysis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D011199:Potentiometry / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D004364:Pharmaceutical Preparations; D064704:Levofloxacin; D015242:Ofloxacin