Effect of amiodarone on functional state of sarcoplasmic reticulum in rat myocardium.
Function of sarcoplasmic reticulum was studied in rat papillary muscles treated with amiodarone. An extra stimulus (0.5 Hz) was delivered to the muscle 0.225 sec after application of a regular stimulus. Postextrasystolic potentiation was evaluated in control myocardial samples and samples treated with amiodarone. The preparation significantly increased all the parameters of postextrasystolic contraction. It was concluded that amiodarone potentiates the ability of sarcoplasmic reticulum to accumulate Ca2+ ions.
D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000502:physiology
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone