title: Antibody directed enzyme prodrug therapy (ADEPT) and related approaches for anticancer therapy.
abstract: In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000187:drug effects; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D057487:Enzyme Therapy; D004798:Enzymes / Q000737:chemistry; D006801:Humans; D011355:Prodrugs / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D004798:Enzymes; D011355:Prodrugs