title: Smoking cessation in methadone maintenance.
abstract: OBJECTIVE
  To evaluate relapse prevention (relapse prevention) and contingency management (contingency management) for optimizing smoking cessation outcomes using nicotine replacement therapy for methadone-maintained tobacco smokers.
  
  
  METHODS
  Experimental, 2 (relapse prevention)x2 (contingency management) repeated measures design using a platform of nicotine replacement therapy featuring a 2-week baseline period, followed by randomization to 12 weeks of treatment, and 6- and 12-month follow-up visits.
  
  
  METHODS
  Three narcotic treatment centers in Los Angeles.
  
  
  METHODS
  One hundred and seventy-five participants who met all inclusion and no exclusion criteria.
  
  
  METHODS
  Participants received 12 weeks of nicotine replacement therapy and assignment to one of four conditions: patch-only, relapse prevention + patch, contingency management + patch and relapse prevention + contingency management + patch.
  
  
  METHODS
  Thrice weekly samples of breath (analyzed for carbon monoxide) and urine (analyzed for metabolites of opiates and cocaine) and weekly self-reported numbers of cigarettes smoked.
  
  
  RESULTS
  Participants (73.1%) completed 12 weeks of treatment. During treatment, those assigned to receive contingency management showed statistically higher rates of smoking abstinence than those not assigned to receive contingencies (F3,4680=6.3, P=0.0003), with no similar effect observed for relapse prevention. At follow-up evaluations, there were no significant differences between conditions. Participants provided more opiate and cocaine-free urines during weeks when they met criteria for smoking abstinence than during weeks when they did not meet these criteria (F1,2054=14.38, P=0.0002; F1,2419=16.52, P<0.0001).
  
  
  CONCLUSIONS
  Contingency management optimized outcomes using nicotine replacement therapy for reducing cigarette smoking during treatment for opiate dependence, although long-term effects are not generally maintained. Findings document strong associations between reductions in cigarette smoking and reductions in illicit substance use during treatment.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D009294:Narcotics / Q000627:therapeutic use*; D009538:Nicotine / Q000627:therapeutic use; D012907:Smoking / Q000523:psychology; D016540:Smoking Cessation / Q000379:methods*; D019966:Substance-Related Disorders / Q000534:rehabilitation*; D014029:Tobacco Use Disorder / Q000534:rehabilitation
chemical_list: D009294:Narcotics; D009538:Nicotine; D008691:Methadone