title: Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.
abstract: Genetic and biochemical research is providing new information on the mechanism of chloroquine resistance. Drug discovery initiatives are finding new leads that have favorable pharmaceutical properties and efficacy against chloroquine-resistant malaria.
mesh_terms: D018528:ATP-Binding Cassette Transporters; D000483:Alleles; D000818:Animals; D000962:Antimalarials / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005075:Biological Evolution; D002738:Chloroquine / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D030561:Databases, Nucleic Acid; D004351:Drug Resistance; D017125:Genes, Protozoan; D014644:Genetic Variation; D018503:Genome, Protozoan; D006418:Heme / Q000378:metabolism; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000469:parasitology; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D026901:Membrane Transport Proteins; D010961:Plasmodium / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D018528:ATP-Binding Cassette Transporters; D000962:Antimalarials; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C416369:PfCRT protein, Plasmodium falciparum; D015800:Protozoan Proteins; C059987:mdr gene protein, Plasmodium; D006418:Heme; D002738:Chloroquine