title: Primary effusion lymphoma with subsequent development of a small bowel mass in an HIV-seropositive patient: a case report and literature review.
abstract: Primary effusion lymphoma is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of a solid tumor mass or dissemination during its clinical course. This lymphoma is typically present in human immunodeficiency virus (HIV)-infected patients and frequently associated with Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV8) viral sequences. Here we report a rare case of KSHV/HHV8-associated primary effusion lymphoma with secondary involvement of the small bowel as an obstructive tumor mass in an HIV-infected man. The solid small bowel lymphoma demonstrated essentially identical morphology, immunophenotype, KSHV/HHV8 viral status, and immunoglobulin light chain rearrangements to the pleural cavity-based primary effusion lymphoma in the same patient.
mesh_terms: D000328:Adult; D006679:HIV Seropositivity; D019288:Herpesvirus 8, Human; D006801:Humans; D016130:Immunophenotyping; D007414:Intestinal Neoplasms / Q000150:complications / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D016483:Lymphoma, AIDS-Related / Q000150:complications / Q000473:pathology*; D008297:Male; D016066:Pleural Effusion, Malignant / Q000150:complications* / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000150:complications / Q000473:pathology*