[Clinico-functional evaluation of the efficacy of treating gastroesophageal reflux disease combined with bronchial asthma with omeprazole].
OBJECTIVE
To investigate the prevalence of gastroesophageal reflux disease (GERD) among patients with bronchial asthma (BA) and to determine the effects of omeprazole therapy on the outcome of asthma in patients with GERD.


METHODS
117 BA patients were examined. Those who had a concomitant GERD were divided into two groups to receive outpatiently omeprazole 40 mg/day or placebo for 8 weeks. Spirometry was performed before and after the treatment. Clinical indices were calculated by daily summarizing of pulmonary (CIEI I) and gastric (CIEI II) symptoms improvement.


RESULTS
The trial showed a significant correlation between CIEI I and CIEI II (r = 0.574, p < 0.001) during 8-week omeprazole therapy. The analysis of PEV and FEV1 dynamics showed a significant improvement (p < 0.05) of bronchial conduction in BA patients receiving omeprazole vs placebo.


CONCLUSIONS
A significant correlation exists between the severity of gastroesophageal refluxes and bronchoobstructive syndrome in BA and GERD patients. Omeprazole treatment of such patients relieves BA and GERD symptoms.
D000328:Adult; D001249:Asthma / Q000150:complications*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D010919:Placebos; D016896:Treatment Outcome
D010919:Placebos; D009853:Omeprazole
Kliniko-funktsional'naia otsenka éffektivnosti lecheniia omeprazolom gastroézofageal'noĭ refliuksnoĭ bolezni pri sochetanii ee s bronkhial'noĭ astmoĭ.