Expression of peanut agglutinin-binding carbohydrates correlates with nodal involvement in human lung adenocarcinoma.
The expression of 15 kinds of lectin-binding carbohydrates was examined histochemically in lung adenocarcinoma. The relation between expression of lectin binding carbohydrates and clinicopathologic factors was studied. The expression of peanut agglutinin (PNA) binding carbohydrates showed a high lymph node metastatic rate. Relation between PNA-binding carbohydrate expression and lymphatic vessel invasion was also recognized. Multivariate analysis showed that PNA-binding carbohydrate expression was an independent predictive factor of lymph node metastasis (odds ratio: 2.8) and of lymphatic vessel invasion (odds ratio: 5.2). The expression of PNA-binding carbohydrates would be a significant predictive factor for lymph node metastasis of lung adenocarcinomas.
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism* / Q000556:secondary; D008198:Lymph Nodes / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019887:Peanut Agglutinin / Q000378:metabolism*; D011379:Prognosis
D015295:Antigens, Tumor-Associated, Carbohydrate; D019887:Peanut Agglutinin