Identification of a new isoform of human IL-12 p35 mRNA.
This study has identified an alternate mRNA isoform of the human interleukin-12 p35 gene differing from normal p35 transcripts by the deletion of exon 3. Exon 3-lacking p35 mRNA was produced by both dendritic cells and Epstein-Barr virus-transformed B cells and was detected only when transcription of normal p35 mRNA was abundant.
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000378:metabolism; D001483:Base Sequence; D003713:Dendritic Cells / Q000378:metabolism; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D053765:Interleukin-12 Subunit p35; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics; D021122:Protein Subunits / Q000235:genetics*; D012333:RNA, Messenger; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment
C508858:IL12A protein, human; D053765:Interleukin-12 Subunit p35; D020033:Protein Isoforms; D021122:Protein Subunits; D012333:RNA, Messenger; D018664:Interleukin-12