Novel synthesis and antifungal activity of pyrrole and pyrrolo[2,3-d]pyrimidine derivatives containing sulfonamido moieties.
Several sulfonamides containing pyrroles (2a-c, 6a-d, 8a-d), pyrrolo[2,3-d] pyrimidines (3a-c), acetanilides (11a-c) and tetrahydrobenzothiophenes (13a-c) were synthesized starting from N4-chloroacetylsulfanilamides (1a-d). The structures of synthesized compounds were elucidated by elemental analyses and spectral data. Compounds 2b, 3b, 6b, 8b and 8d exhibited a remarkable antifungal activity compared with the standard fungicide mycostatine.
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000935:Antifungal Agents; D011743:Pyrimidines; D011758:Pyrroles; C450639:Pyrrolo(2,3-d)pyrimidine; D013449:Sulfonamides