In vitro effects of alcohols and their metabolites on antibody-forming activity of T and B lymphocytes.
In vitro experiments on splenocytes from noninbred mice showed that ethylene glycol, methanol, and ethanol dose-dependently suppressed functional activity of T and B cells. These compounds in equimolar concentrations (10, 100, and 500 mM) produced similar effects, hence their immunotoxicity is determined by their metabolites. The suppressive effects of alcohol biotransformation products to antibody-forming activity of T and B cells decreased in the following order: glyoxylic acid - formic acid - glycolaldehyde - glycolic acid - acetaldehyde. The effects of these substances were dose-dependent. Suppression of T cells was more pronounced.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D019855:Ethylene Glycol / Q000494:pharmacology*; D008297:Male; D000432:Methanol / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000431:Ethanol; D019855:Ethylene Glycol; D000432:Methanol