Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher's disease.
A splenectomised patient with Gaucher's disease who developed multiple foci of osteomyelitis and soft tissue abcesses, after a severe episode of group C salmonella sepsis, is described. Aggressive antibiotic treatment and surgical drainage had little effect and the patient's condition continued to deteriorate. With initiation of enzyme replacement therapy (ERT) in addition to specific antibiotic treatment, defervescence and gradual healing occurred. Complete resolution of the infection was seen after 15 months. The possible role of ERT in healing bacterial infections in Gaucher's disease is discussed.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005776:Gaucher Disease / Q000150:complications* / Q000188:drug therapy; D005962:Glucosylceramidase / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D012480:Salmonella Infections / Q000150:complications / Q000188:drug therapy*; D018461:Soft Tissue Infections / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; C070292:alglucerase; D005962:Glucosylceramidase