Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics.
The lanthanide ion based macrocyclic complexes 1.Ln mimic the hydrophobic nature of ribonucleases, where the lanthanide ions induce the formation of a hydrophobic cavity for 1, giving rise to a large order of magnitude enhancement in the hydrolytic cleavage of HPNP.
D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008024:Ligands; D018716:Molecular Mimicry; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012333:RNA, Messenger / Q000737:chemistry*; D012260:Ribonucleases / Q000737:chemistry*
C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D028581:Lanthanoid Series Elements; D008024:Ligands; D010755:Organophosphates; D009943:Organophosphorus Compounds; D012333:RNA, Messenger; D012260:Ribonucleases