Drosophila melanogaster as a model system for drug discovery and pathway screening.
Although the freakish nightmare world of Mr Samsa may seem completely divorced from our view of the real world, the comparisons between the Drosophila and human genomes indicate that we are a lot closer to insects than we like to think. The use of sophisticated genetic approaches combined with emerging genomics technologies suggest that the fly has much to offer as a tool for understanding basic cellular processes and provides an attractive and complex model system for exploring the molecular basis of human diseases such as cancer, Alzheimer's disease and Huntington's disease.
D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004700:Endocrine System Diseases / Q000235:genetics / Q000503:physiopathology; D023281:Genomics; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics / Q000503:physiopathology; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D009422:Nervous System Diseases / Q000188:drug therapy / Q000235:genetics; D010600:Pharmacology / Q000639:trends*; D012890:Sleep / Q000235:genetics / Q000502:physiology