Nonenzymatic antioxidant activity of four organosulfur compounds derived from garlic.
The nonenzymatic antioxidant activity of diallyl sulfide (DAS), diallyl disulfide (DADS), S-ethyl cysteine (SEC), and N-acetyl cysteine (NAC) in the liposome system was examined. The antioxidant protection from these organosulfur agents was concentration dependent (p < 0.05). SEC and NAC showed significantly lower lipophilicity and greater reducing power than DAS and DADS (p < 0.05). Greater antioxidant protection was presented in the combinations of alpha-tocopherol with four organosulfur agents than alpha-tocopherol treatment alone (p < 0.05), and SEC and NAC showed greater sparing effects on alpha-tocopherol (p < 0.05). Four organosulfur agents lost antioxidant activity when the temperature was 65 degrees C (p < 0.05). At pH 2.5 and 10, DAS and DADS still showed antioxidant activity (p < 0.05). On the basis of the observed nonenzymatic antioxidant protection, these organosulfur compounds are potent agents for enhancing lipid stability.
D000111:Acetylcysteine / Q000032:analysis / Q000494:pharmacology; D000498:Allyl Compounds / Q000032:analysis / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology; D004220:Disulfides / Q000032:analysis / Q000494:pharmacology; D005737:Garlic / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation / Q000187:drug effects; D013440:Sulfides / Q000032:analysis / Q000494:pharmacology; D013457:Sulfur Compounds / Q000032:analysis* / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000494:pharmacology
D000498:Allyl Compounds; D000975:Antioxidants; D004220:Disulfides; D013440:Sulfides; D013457:Sulfur Compounds; C028009:diallyl disulfide; C038491:allyl sulfide; C026826:S-ethylcysteine; D024502:alpha-Tocopherol; D003545:Cysteine; D000111:Acetylcysteine