title: Posttraining intra-basolateral amygdala scopolamine impairs food- and amphetamine-induced conditioned place preferences.
abstract: The present study investigated the role of cholinergic muscarinic receptor function within the basolateral amygdala memory in the consolidation of conditioned place preference (CPP) memory. Adult male Long-Evans rats were confined to treatment- or nontreatment-paired compartments for 30 min on 4 alternating days. After training, rats received intrabasolateral amygdala infusions of scopolamine (2.5 microg or 5.0 microg/0.5 microl) or saline. The rats were then given a 20-min test session, and the time spent in each of the compartments was recorded. Immediate posttraining (but not delayed 2 hr) scopolamine (5.0 microg) blocked acquisition of food- and amphetamine-induced CPPs. The findings indicate a time-dependent role for basolateral amygdala muscarinic receptors in memory consolidation underlying CPPs for natural and drug rewards.
mesh_terms: D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000679:Amygdala / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001931:Brain Mapping; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D012601:Scopolamine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; D018727:Muscarinic Antagonists; D000661:Amphetamine; D012601:Scopolamine