title: A simple method for quantifying fentanyl, sufentanil, or morphine in discard syringes from anesthesia procedures.
abstract: Fentanyl, sufentanil, and morphine are commonly used in the conduct of anesthesia. Medical staff working with these drugs are at high risk of addiction. To detect and prevent diversion, a method was developed to quantify these drugs in discard syringes using the BioRad REMEDi HS Drug Profiling System. For fentanyl, the lowest concentration detected is 0.1 microg/mL, and the assay is linear to 5.0 microg/mL; the within-run coefficient of variation (CV) is 0.9% (n = 5), and between-run CV is 2.5% (n = 20). For sufentanil, the lowest concentration detected is 0.5 microg/mL, and the assay is linear to 11.0 microg/mL; the within-run CV is 2.0% (n = 5), and the between-run CV is 2.4% (n = 20). For morphine, the lowest concentration detected is 0.5 microg/mL, and the assay is linear to 10.0 microg/mL; the within-run CV is 11.6% (n = 5), and between-run CV is 11.3% (n = 20). Other drugs commonly used in the operating room were checked for cross-reactivity on the REMEDi HS; none cross-reacted. The REMEDi HS can be used for rapid, accurate quantification of fentanyl, sufentanil, and morphine in discard syringes from anesthesia procedures or related medical applications.
mesh_terms: D000771:Anesthesia, Intravenous / Q000706:statistics & numerical data; D005283:Fentanyl / Q000032:analysis*; D009020:Morphine / Q000032:analysis*; D015813:Substance Abuse Detection / Q000295:instrumentation / Q000379:methods; D017409:Sufentanil / Q000032:analysis*; D013594:Syringes / Q000706:statistics & numerical data
chemical_list: D009020:Morphine; D017409:Sufentanil; D005283:Fentanyl