title: Glycine receptors and transporters on bullfrog retinal Müller cells.
abstract: Glycine is a principal inhibitory neurotransmitter in the vertebrate retina. We have characterized glycine-induced currents from Müller cells in the bullfrog retinal slice preparation using whole-cell recordings. The glycine-induced current was partially suppressed by strychnine, and the remaining strychnine-resistant component was sacrosine-sensititve, suggesting that these two components may be mediated by glycine receptors and glycine transporters, respectively. Furthermore, the two components were maximal at the inner nuclear layer (INL) and declined asymmetrically as the application site was moved away from the INL to either the external or internal limiting membranes. It is suggested that Müller cells may be involved in glycinergic transmission by communicating with retinal neurons through these receptors and transporters.
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology*; D005998:Glycine / Q000494:pharmacology; D018684:Glycine Agents / Q000494:pharmacology; D050487:Glycine Plasma Membrane Transport Proteins; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009924:Organ Culture Techniques; D011892:Rana catesbeiana; D018009:Receptors, Glycine / Q000187:drug effects / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D012521:Sarcosine / Q000494:pharmacology; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014785:Vision, Ocular / Q000187:drug effects / Q000502:physiology
chemical_list: D026921:Amino Acid Transport Systems, Neutral; D018684:Glycine Agents; D050487:Glycine Plasma Membrane Transport Proteins; D018009:Receptors, Glycine; D013331:Strychnine; D005998:Glycine; D012521:Sarcosine