title: Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics.
abstract: The lanthanide ion based macrocyclic complexes 1.Ln mimic the hydrophobic nature of ribonucleases, where the lanthanide ions induce the formation of a hydrophobic cavity for 1, giving rise to a large order of magnitude enhancement in the hydrolytic cleavage of HPNP.
mesh_terms: D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008024:Ligands; D018716:Molecular Mimicry; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012333:RNA, Messenger / Q000737:chemistry*; D012260:Ribonucleases / Q000737:chemistry*
chemical_list: C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D028581:Lanthanoid Series Elements; D008024:Ligands; D010755:Organophosphates; D009943:Organophosphorus Compounds; D012333:RNA, Messenger; D012260:Ribonucleases