Diabetic neuropathic foot ulcers: the association of wound size, wound duration, and wound grade on healing.
OBJECTIVE
The goal of this study was to evaluate whether simple risk factors can be identified that successfully characterize who will heal and who will not heal among patients who have received standard therapy for diabetic neuropathic foot ulcers.


METHODS
For this cohort study, we evaluated >31,000 individuals with a diabetic neuropathic foot ulcer seen in the Curative Health Services System. Using multivariate logistic regression, we evaluated the association between wound size, wound duration, wound grade, and other variables and their effect on whether a patient would heal by the 20th week of care.


RESULTS
We demonstrated that wound size, wound duration, and wound grade are all significantly associated with the likelihood of a wound healing by the 20th week of care. In addition, we noted that these associations were not significantly affected by the treating wound care center, whether the unit of analysis was one wound on a patient or all of their wounds, or current adjuvant therapies.


CONCLUSIONS
We have shown that three easy-to-measure risk factors are associated with a wound healing. These results should help clinicians understand the likelihood that a wound will heal and help those conducting clinical investigations to design better trials.
D000368:Aged; D015331:Cohort Studies; D017719:Diabetic Foot / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000473:pathology*; D005260:Female; D016523:Foot Ulcer / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*