Plasmid encoding interferon-gamma exacerbates reovirus type-2-induced diabetes in DBA/1 suckling mice.
This study was designed to examine the effects of administration of a plasmid encoding interferon(IFN)-gamma on reovirus type-2(Reo-2)-induced autoimmune insulitis in suckling DBA/1 mice. Cumulative incidences of diabetes and insulitis at 17 days post-infection in the mice treated with IFN-gamma-encoding plasmid were higher than those in control mice treated with "empty" plasmid. These results suggested that the IFN-gamma-encoding plasmid promoted autoimmune insulitis in Reo-2-induced diabetes.
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology / Q000821:virology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000473:pathology / Q000821:virology*; D005260:Female; D007371:Interferon-gamma / Q000235:genetics* / Q000276:immunology; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D030102:Orthoreovirus, Mammalian / Q000235:genetics* / Q000472:pathogenicity; D010957:Plasmids / Q000008:administration & dosage / Q000235:genetics*; D012088:Reoviridae Infections / Q000097:blood / Q000150:complications* / Q000473:pathology
D001786:Blood Glucose; D007371:Interferon-gamma