Acid-accelerated DNA-cleaving activities of antitumor antibiotic varacin.
It is demonstrated in this report that the authentic molecular structure of antibiotic varacin is capable of causing DNA-cleavage with high efficiency in the presence of thiols. In addition, it is found that the DNA-cleaving activity by varacin is apparently promoted by its acidic environments.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage; D004278:DNA, Superhelical / Q000187:drug effects / Q000378:metabolism; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005021:Ethylamines / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D008623:Mercaptoethanol / Q000494:pharmacology; D010957:Plasmids / Q000187:drug effects / Q000378:metabolism; D013440:Sulfides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D004278:DNA, Superhelical; D005021:Ethylamines; D013440:Sulfides; C093885:varacin A; D008623:Mercaptoethanol; D004317:Doxorubicin; D004247:DNA