title: Klinefelter's syndrome and precocious puberty: a harbinger for tumor.
abstract: Boys with Klinefelter's syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter's syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed type with seminomatous elements. The differential diagnosis of precocious puberty includes mediastinal tumors, especially in boys with Klinefelter's syndrome.
mesh_terms: D002648:Child; D015897:Comorbidity; D003937:Diagnosis, Differential; D004814:Epidermal Cyst / Q000175:diagnosis / Q000453:epidemiology; D018237:Germinoma / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007713:Klinefelter Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000453:epidemiology; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000453:epidemiology