title: Toxicity of cobra venom components to cockroach Gromphadorhina portentosa.
abstract: The toxicity of the Thailand and Middle-Asian cobra venoms as well as of their isolated components (neurotoxins, cytotoxins, phospholipases and some others) for cockroach Gromphadorhina portentosa was studied. It was found that, as compared to mammals, cockroaches are more resistant to cobra venoms and their components. At intraabdominal injection the most toxic for cockroaches were cytotoxins (LD(50) 1.5-2.3 nmol/g). Acidic phospholipase A(2) CM II is less active (2.85 nmol/g), while alpha-neurotoxins, being the most toxic venom components for mice (LD(50) 0.01-0.03 nmol/g), are not toxic for cockroaches at doses up to 15 nmol/g.
mesh_terms: D000818:Animals; D001681:Biological Assay; D005591:Chemical Fractionation; D003058:Cockroaches / Q000187:drug effects*; D003603:Cytotoxins / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004546:Elapid Venoms / Q000737:chemistry / Q000633:toxicity*; D017815:Elapidae / Q000502:physiology*; D007928:Lethal Dose 50; D051379:Mice; D009498:Neurotoxins / Q000633:toxicity; D010741:Phospholipases A / Q000633:toxicity; D013045:Species Specificity
chemical_list: D003603:Cytotoxins; D004546:Elapid Venoms; D009498:Neurotoxins; D010741:Phospholipases A