An improved method for the preparation of [11C]verapamil.
This paper describes an improved preparation of [11C]verapamil by reaction of [11C]methyl triflate with desmethylverapamil. The optimal reaction temperature, amount of precursor and reaction time were assessed. With this method [11C]verapamil can be prepared with a reproducible radiochemical yield of 66 +/- 4% (EOB, based on [11C]methyltriflate). Total synthesis time was 60 min. Radiochemical purity was >99% and specific activities varied between 5 and 30TBq/mmol.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000737:chemistry; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008698:Mesylates; D008722:Methods; D011854:Radiochemistry; D013696:Temperature; D014055:Tomography, Emission-Computed; D014700:Verapamil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000302:isolation & purification
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002250:Carbon Radioisotopes; D008698:Mesylates; C078465:methyl triflate; D014700:Verapamil