Family history study of posttraumatic stress disorder with secondary psychotic symptoms.
OBJECTIVE
A family history approach was used to determine if posttraumatic stress disorder (PTSD) with secondary psychotic symptoms was associated with a familial vulnerability to schizophrenia and other psychoses.


METHODS
Family history methods were used to compare rates of familial psychopathology in the first-degree relatives of three proband groups: 1) patients with DSM-IV PTSD with secondary psychotic symptoms, 2) patients with DSM-IV PTSD without psychotic symptoms, and 3) healthy matched comparison subjects.


RESULTS
PTSD with secondary psychotic symptoms was not associated with an excess of familial psychotic disorder but was associated with a higher morbid risk for depression.


CONCLUSIONS
PTSD with secondary psychotic symptoms was not associated with familial psychosis, suggesting it does not reflect the presence of an underlying psychotic disorder.
D001008:Anxiety Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics; D012565:Schizophrenic Psychology; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology