Nucleocytoplasmic transport: more than the usual suspects.
A paper in the August 9 issue of Cell describes a novel role for the nucleoporin Npap60/Nup50 as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. These findings add a new dimension of complexity to the current understanding of protein transport pathways.
D021581:Active Transport, Cell Nucleus; D000818:Animals; D001693:Biological Transport, Active; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D020931:ran GTP-Binding Protein / Q000378:metabolism
D028861:Nuclear Pore Complex Proteins; D009687:Nuclear Proteins; D020931:ran GTP-Binding Protein