The first Noonan syndrome gene: PTPN11, which encodes the protein tyrosine phosphatase SHP-2.
D004742:Enhancer Elements, Genetic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009154:Mutation; D009634:Noonan Syndrome / Q000201:enzymology / Q000235:genetics*; D011401:Promoter Regions, Genetic; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases