title: [Conjugate vaccines].
abstract: Conjugate vaccines extend the vaccinal prevention for children to more diseases. Conjugating the capsular polysaccharide to a carrier protein transforms a T-independent antigen in a T-dependent, allowing protection of the children (before 2 years of age) against Haemophilus influenzae type b, meningococcal C and pneumococcal infections. This article reviews the 3 conjugate vaccines and their results with focus on some questions: antigens interference in the immunological response, serological subrogate for protection, herd immunity and replacement of circulating serotypes.
mesh_terms: D006192:Haemophilus Infections / Q000276:immunology / Q000517:prevention & control; D019741:Haemophilus influenzae type b / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control; D018074:Vaccines, Conjugate / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D018074:Vaccines, Conjugate
vernacular_title: Les vaccins conjugués.