Development of liver dysfunction after delivery is possibly due to postpartum autoimmune hepatitis. A report of three cases.
Autoimmune diseases, especially autoimmune thyroid disease, frequently develop after delivery due to the immune rebound mechanism. Most cases involve transient dysfunction of affected organs. We examined three patients who developed liver dysfunction after delivery. They were all diagnosed with definite or probable autoimmune hepatitis using the scoring system of the International Autoimmune Hepatitis Group. Moreover, all of them had anti-CYP2D6 antibodies detected by a sensitive radioligand assay. Our findings strongly suggest that liver dysfunction is induced by postpartum autoimmune hepatitis, and clinicians should be aware of this disease.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications* / Q000175:diagnosis; D001706:Biopsy; D004796:Clinical Enzyme Tests; D019389:Cytochrome P-450 CYP2D6 / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006505:Hepatitis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000175:diagnosis; D013997:Time Factors
D001323:Autoantibodies; D019389:Cytochrome P-450 CYP2D6