The effect of propofol on increased superoxide concentration in cultured rat cerebrocortical neurons after stimulation of N-methyl-d-aspartate receptors.
The neuroprotective properties of propofol may be because of its action as an antioxidant. To investigate whether propofol reduces the N-methyl-D-aspartate-induced increase in superoxide anion levels, the fluorescence of dihydroethidium acetoxymethylester, as an indicator for cellular superoxide concentration, was measured in cultured rat forebrain neurons.
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005456:Fluorescent Dyes; D016166:Free Radical Scavengers / Q000494:pharmacology*; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010617:Phenanthridines; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists*; D013481:Superoxides / Q000378:metabolism*
D018686:Anesthetics, Intravenous; D018690:Excitatory Amino Acid Agonists; D005456:Fluorescent Dyes; D016166:Free Radical Scavengers; D010617:Phenanthridines; D016194:Receptors, N-Methyl-D-Aspartate; D013481:Superoxides; C058428:hydroethidine; D016202:N-Methylaspartate; D015742:Propofol