Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.
Genetic and biochemical research is providing new information on the mechanism of chloroquine resistance. Drug discovery initiatives are finding new leads that have favorable pharmaceutical properties and efficacy against chloroquine-resistant malaria.
D018528:ATP-Binding Cassette Transporters; D000483:Alleles; D000818:Animals; D000962:Antimalarials / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005075:Biological Evolution; D002738:Chloroquine / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D030561:Databases, Nucleic Acid; D004351:Drug Resistance; D017125:Genes, Protozoan; D014644:Genetic Variation; D018503:Genome, Protozoan; D006418:Heme / Q000378:metabolism; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000469:parasitology; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D026901:Membrane Transport Proteins; D010961:Plasmodium / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA
D018528:ATP-Binding Cassette Transporters; D000962:Antimalarials; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C416369:PfCRT protein, Plasmodium falciparum; D015800:Protozoan Proteins; C059987:mdr gene protein, Plasmodium; D006418:Heme; D002738:Chloroquine