SCAP, an ER sensor that regulates cell cholesterol.
Cells keep their cholesterol in balance by sensing its level in the endoplasmic reticulum and transducing this information into the expression of multiple homeostatic genes. Two recent papers from the Brown and Goldstein laboratory provide important new insights into how an integral ER protein, SCAP, mediates this process.
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D002784:Cholesterol / Q000378:metabolism* / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism; D007425:Intracellular Membranes / Q000737:chemistry / Q000187:drug effects; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D017354:Point Mutation; D011485:Protein Binding / Q000502:physiology; D011487:Protein Conformation / Q000187:drug effects; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D013261:Sterols / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism
D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C102196:SREBP cleavage-activating protein; D013261:Sterols; D014157:Transcription Factors; D002784:Cholesterol; D014357:Trypsin