title: Effect of platelet growth factors on proliferation of guinea pig bone marrow and splenic stromal precursor cells and proliferation of cultural descendants from bone marrow precursor cells.
abstract: Elimination of platelets from guinea pig splenocyte suspension (lacking megakaryocytes) with EDTA considerable reduces the efficiency cloning of splenic stromal precursor cells. It means that platelet-derived growth factors are necessary for stromal precursor cells from different organs (bone marrow, thymus, and spleen). The dependence on the platelet growth factors can vary within a wide range in descendants from cultured bone marrow precursor cells (passaged bone marrow fibroblasts at different stages of differentiation.
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D005260:Female; D006133:Growth Substances / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects*
chemical_list: D006133:Growth Substances