A new anti-oedematogenic nor-pregnane derivative isolated from Mandevilla illustris.
A new nor-pregnane derivative (2,6-dideoxy-3- O-methylpyranosylillustrol) (1), isolated from the ethyl acetate extract of Mandevilla illustris rhizomes, was identified by conventional spectral analysis and by chemical means. It markedly inhibited the rat paw oedema induced by carrageenan and, to a lesser extent, those induced by dextran, without affecting that caused by bradykinin.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029062:Apocynaceae; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006614:Hindlimb / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry
C469490:2,6-dideoxy-3- O-methylpyranosylillustrol; D000893:Anti-Inflammatory Agents; D003911:Dextrans; D010840:Phytosterols; D010936:Plant Extracts; D011278:Pregnanes; C024626:bradykinin, des-Arg(9)-; D002351:Carrageenan; D001920:Bradykinin