title: [Brain edema in meningiomas: radiological and histological factors].
abstract: Many factors have been associated to the development of peritumoral edema in meningiomas. We studied the radiological and pathological features of 51 intracranial meningiomas surgically treated in the University Hospital of the Federal University of Rio de Janeiro. Two thirds of the meningiomas in our series had peritumoral edema. The size of the meningioma was probably related to the development of edema. Peritumoral edema was found frequently in the large meningiomas. The location of the meningioma was also associated with the frequency of peritumoral edema. Sphenoid wing meningiomas had significantly more peritumoral edema. In contrast, tuberculum sellae meningiomas were almost never associated with cerebral edema. There is growing evidence in the literature that vascular endothelial growth factor (VEGF) is a key factor in the pathogenesis of peritumoral edema. We studied by immunohistochemical techniques the expression of VEGF and its receptor flk-1 in meningiomas.
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001929:Brain Edema / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology*; D001932:Brain Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis; D016014:Linear Models; D008222:Lymphokines / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000032:analysis; D042442:Vascular Endothelial Growth Factors
chemical_list: D014408:Biomarkers, Tumor; D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D040301:Vascular Endothelial Growth Factor Receptor-2
vernacular_title: Edema cerebral em meningiomas: aspectos radiológicos e histopatológicos.