The bacterial ribosome, a promising focus for structure-based drug design.
Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be used in the design of appropriate modifications to existing antibiotics as well as in the discovery of completely new drug classes.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000648:ultrastructure*; D019295:Computational Biology; D015195:Drug Design; D012270:Ribosomes / Q000737:chemistry / Q000187:drug effects*
D000900:Anti-Bacterial Agents