Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compounds.
Research in the 20th century initially identified arylamines as causative factors in occupational carcinogenesis, especially bladder cancer, and subsequently identified arylamines as a major class of mutagens/carcinogens in the environment and diet that are potential risk factors in a variety of human cancers. Current research focuses on understanding of mechanisms of arylamine carcinogenesis, such as the role of metabolic processing, DNA adduct formation, and mutagenesis, and learning more about the molecular alterations in carcinomas induced by these compounds. Furthermore, research to identify human exposures, including developing more sensitive methods for analyzing environmental samples and identifying suitable biomarkers are important aspects of contemporary investigations. In addition, better evaluation of the risk of these compounds in human cancer especially with regard to the impact of genetic polymorphisms is a major focus of research in this field. Although current population studies have sometimes been described as equivocal, improved tools for epidemiology, refined human biomonitoring methods and collaborative endeavors to study multiple population groups now provide a better means to ultimately define the role of arylamines in human carcinogenesis. The purpose of the Eighth International Conference on Carcinogenic/Mutagenic N-Substituted Aryl Compounds, held in Washington, DC, 12-14 November 2001, was to explore the current scope of studies on arylamine carcinogenesis among scientists in basic research and epidemiology and to discuss future research priorities. With the intent of providing a view to the current field of research on aromatic amines, this review presents a synopsis of the Proceedings of the Eighth International Conference and highlights the manuscripts contained in this special issue of Mutation Research.
D000611:Aminobiphenyl Compounds / Q000009:adverse effects*; D002273:Carcinogens / Q000009:adverse effects*; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D018736:DNA Adducts / Q000032:analysis; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000235:genetics; D004032:Diet; D004784:Environmental Monitoring; D006801:Humans; D009153:Mutagens / Q000009:adverse effects*; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics; D012307:Risk Factors
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; D002274:Carcinogens, Environmental; D018736:DNA Adducts; D004273:DNA, Neoplasm; D009153:Mutagens