Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.
Expression of 15,247 clones from a cDNA library in the heart of mice receiving Vilon and Epithalon was studied by DNA-microarray technology. We revealed 300 clones (1.94% of the total count), whose expression changed more than by 2 times. Vilon changed expression of 36 clones, while Epithalon modulated expression of 98 clones. Combined treatment with Vilon and Epithalon changed expression of 144 clones. Vilon alone or in combination with Epithalon activated expression of 157 clones (maximally by 6.13 times) and inhibited expression of 23 clones (maximally by 2.79 times). Epithalon alone or in combination with Vilon activated expression of 194 clones (maximally by 6.61 times) and inhibited expression of 48 clones (maximally by 2.71 times). Our results demonstrate the specific effects of Epithalon and Vilon on gene expression.
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling; D006321:Heart / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009206:Myocardium / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D009842:Oligopeptides / Q000494:pharmacology*
D017931:DNA Primers; D004151:Dipeptides; D009842:Oligopeptides; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine