Proinsulin C-peptide--a consensus statement.
In recent years the physiological role of the proinsulin C-peptide has received increasing attention, focusing on the potential therapeutic value of C-peptide replacement in preventing and ameliorating type 1 diabetic complications. In order to consolidate these new data and to identify the immediate directions of C-peptide research and its clinical usefulness, an International Symposium was held in Detroit, Michigan, on October 20-21, 2000, under the auspices of the Wayne State University/Morris Hood Jr. Comprehensive Diabetes Center. In this communication, we review the cellular, physiological and clinical effects of C-peptide replacement in animal models and in patients with type 1 diabetes. Finally, recommendations are presented as to the most urgent studies that should be pursued to further establish the biological action of C-peptide and its therapeutic value.
D017209:Apoptosis; D002096:C-Peptide / Q000502:physiology*; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D011384:Proinsulin / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002096:C-Peptide; D011384:Proinsulin; D000254:Sodium-Potassium-Exchanging ATPase