[The effect of innervation, hormonal and mechanical factors on expression of myosin isoforms in human skeletal muscle].
In this study direction and dynamics in the expression of the myosin heavy chain isoforms (MHCemb, MHCneo, MHC-I, MHC-IIa, MHC-IIx) in the human skeletal muscles in response to innervation, mechanical overloading, unloading, immobilisation and hormones are presented. Transduction of the signal from the mRNA level to the new protein synthesis is presented. Potential applications of the possibilities of the muscle fiber transformations in medicine and physiotherapy are considered.
D000222:Adaptation, Physiological; D000818:Animals; D001696:Biomechanical Phenomena; D006728:Hormones / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000294:innervation* / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction; D016474:Weight-Bearing / Q000502:physiology
D006728:Hormones; D012333:RNA, Messenger; D018995:Myosin Heavy Chains
Wpływ unerwienia, czynników hormonalnych i mechanicznych na ekspresje izoform miozyny w mieśniach szkieletowych człowieka.