Pharmaceutical availability of betamethasone dipropionate and gentamicin sulfate from cream and ointment.
Kinetics of drug release from both compared preparations occuring as a cream and ointment, was in vitro studied. A reversed-phase HPLC method was developed for the determination of betamethasone dipropionate in lipophylic bases. Analyses were performed using a PLRP column with a mobile phase of methanol-acetonitrile-water and ultraviolet detection at lambda = 254 nm. The calibration curve was constructed for concentration (.0-50.0 microg/ml. The method is simple, accurate and precise. For the determination of gentamicin sulfate the FPIA method was used.
D001623:Betamethasone / Q000031:analogs & derivatives* / Q000032:analysis* / Q000493:pharmacokinetics; D001682:Biological Availability; D005839:Gentamicins / Q000032:analysis* / Q000493:pharmacokinetics; D009824:Ointments; D004364:Pharmaceutical Preparations / Q000032:analysis
D005839:Gentamicins; D009824:Ointments; D004364:Pharmaceutical Preparations; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone