Corticatic acids D and E, polyacetylenic geranylgeranyltransferase type I inhibitors, from the marine sponge Petrosia corticata.
Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosia corticata along with the known corticatic acid A (1) as geranylgeranyltransferase type I (GGTase I) inhibitors. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compounds 1-3 inhibited GGTase I from Candida albicans with IC(50) values of 1.9-7.3 microM.
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000595:Amino Acid Sequence; D000818:Animals; D002176:Candida albicans / Q000201:enzymology; D002853:Chromatography, Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004952:Esters / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053279:Polyynes; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
D004791:Enzyme Inhibitors; D004952:Esters; D005231:Fatty Acids, Unsaturated; C470804:corticatic acid D; C470803:corticatic acid E; C091310:corticatic acid A; D053279:Polyynes; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I