title: Plasticity and corticofugal modulation for hearing in adult animals.
abstract: The descending (corticofugal) auditory system adjusts and improves auditory signal processing in the subcortical auditory nuclei. The auditory cortex and corticofugal system evoke small, short-term changes of the subcortical auditory nuclei in response to a sound repetitively delivered to an animal. These changes are specific to the parameters characterizing the sound. When the sound becomes significant to the animal through conditioning (associative learning), the changes are augmented and the cortical changes become long-term. There are two types of reorganizations: expanded reorganization resulting from centripetal shifts in tuning curves of neurons toward the values of the parameters characterizing a sound and compressed reorganization resulting from centrifugal shifts in tuning curves of neurons away from these values. The two types of reorganizations are based on a single mechanism consisting of two components: facilitation and inhibition.
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000502:physiology*; D001306:Auditory Pathways / Q000166:cytology / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D002685:Chiroptera / Q000033:anatomy & histology / Q000502:physiology; D003213:Conditioning, Psychological / Q000502:physiology; D004525:Efferent Pathways / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents