title: A multichannel scala tympani electrode array incorporating a drug delivery system for chronic intracochlear infusion.
abstract: We have developed a novel scala tympani electrode array suitable for use in experimental animals. A unique feature of this array is its ability to chronically deliver pharmacological agents to the scala tympani. The design of the electrode array is described in detail. Experimental studies performed in guinea pigs confirm that this array can successfully deliver various drugs to the cochlea while chronically stimulating the auditory nerve.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D003051:Cochlea / Q000187:drug effects* / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D003056:Cochlear Nerve / Q000502:physiology; D004558:Electric Stimulation; D004867:Equipment Design; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006168:Guinea Pigs; D015918:Infusion Pumps, Implantable; D008839:Microelectrodes; D009355:Neomycin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D012533:Scala Tympani
chemical_list: D000900:Anti-Bacterial Agents; D009355:Neomycin