Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.
Interleukin-17 (IL-17) is a proinflammatory cytokine produced by T cells. The involvement of IL-17 in human diseases has been suspected because of its detection in sera from asthmatic patients and synovial fluids from arthritic patients. In this study, we generated IL-17-deficient mice and investigated the role of IL-17 in various disease models. We found that contact, delayed-type, and airway hypersensitivity responses, as well as T-dependent antibody production, were significantly reduced in the mutant mice, while IL-17 deficiency of donor T cells did not affect acute graft-versus-host reaction. The results suggest that impaired responses were caused by the defects of allergen-specific T cell activation. Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses.
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D016535:Bronchial Hyperreactivity / Q000235:genetics / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured / Q000276:immunology; D018920:Coculture Techniques; D003713:Dendritic Cells / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000235:genetics / Q000276:immunology; D004139:Dinitrofluorobenzene / Q000031:analogs & derivatives* / Q000276:immunology; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000235:genetics / Q000276:immunology*; D007111:Immunity, Cellular; D020381:Interleukin-17 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008211:Lymphocyte Cooperation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008934:Mitogens / Q000494:pharmacology; D023421:Models, Animal; D009532:Nickel / Q000276:immunology; D010853:Picryl Chloride / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000637:transplantation; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000172:deficiency / Q000502:physiology
D006241:Haptens; D020381:Interleukin-17; D008934:Mitogens; D014409:Tumor Necrosis Factor-alpha; C045305:2,4-dinitrofluorobenzene sulfonic acid; D009532:Nickel; D004139:Dinitrofluorobenzene; D010853:Picryl Chloride