Coproverdine, a novel, cytotoxic marine alkaloid from a new zealand ascidian.
The crude extract of a New Zealand ascidian displayed antitumor activity. Bioassay-directed fractionation yielded a novel alkaloid, coproverdine (1). The structure of 1 was assigned on the basis of detailed spectroscopic analysis. Coproverdine (1) was responsible for the antitumor activity of the crude extract.
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D008175:Lung Neoplasms; D008297:Male; D008545:Melanoma; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D011471:Prostatic Neoplasms; D021241:Spectrometry, Mass, Electrospray Ionization; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C470530:coproverdine