The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.
The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.
D000818:Animals; D002522:Chlorocebus aethiops; D004285:Dogs; D015536:Down-Regulation; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D009980:Influenza A virus / Q000235:genetics / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D012330:RNA, Double-Stranded; D018808:Transcription Factor AP-1 / Q000378:metabolism*; D015854:Up-Regulation; D014709:Vero Cells; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*
C085820:INS1 protein, influenza virus; D012330:RNA, Double-Stranded; D018808:Transcription Factor AP-1; D017361:Viral Nonstructural Proteins; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases