title: Mouse models of male infertility.
abstract: Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility.
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004195:Disease Models, Animal; D005640:Follicle Stimulating Hormone / Q000502:physiology; D005854:Germ Cells / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D006801:Humans; D007248:Infertility, Male / Q000473:pathology / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000502:physiology; D008297:Male; D008540:Meiosis / Q000502:physiology; D051379:Mice; D013091:Spermatogenesis / Q000502:physiology; D013737:Testis / Q000033:anatomy & histology / Q000502:physiology
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone