Photoprocesses of photosensitizing drugs within cyclodextrin cavities.
Recently some interest has been focused on the photobehavior of CD-drug inclusion complexes in relation to the problem of the biological photosensitization by drugs. This review is dedicated to the illustration of the mechanistic aspects of the photoprocesses occurring in some non-steroidal anti-inflammatory drugs (NSAIDs), with photosensitising side effects, within CD cavities. It is shown how the photobehavior of the CD-drug associates can help to model the photoreactivity of the drugs in biological sites. The limitations for the use of CDs as protective systems for the clinical administration of photosensitising drugs is also evidenced.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000737:chemistry*; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D017382:Reactive Oxygen Species
D003505:Cyclodextrins; D004364:Pharmaceutical Preparations; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species