[Correlation between the onset of early proteinuria and the outcome of renal transplantation. Experience of a single centre].
BACKGROUND
Proteinuria is associated with an increased risk of renal failure. In chronic kidney transplant failure it is associated with poorer graft outcome.


METHODS
In our Unit 405 renal transplants were performed between April 1992 and December 2001. We analysed 1) the main causes of post-transplant proteinuria and 2) the prognostic significance for graft outcome in patients with a minimum follow-up of 6 months.


RESULTS
Early proteinuria was associated with a higher incidence of chronic allograft nephropathy (CAN) and de novo/recurrent nephropathies. Graft outcome was poorer in patients with early persistent proteinuria.


CONCLUSIONS
Proteinuria after renal transplantation increases the risk of graft failure. We can, therefore, hypothesize that a graft biopsy is the best way to reveal the causes of proteinuria so that therapeutic interventions, which have been shown to reduce proteinuria, can be applied immediately.
D000328:Adult; D001706:Biopsy; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000652:urine*; D006801:Humans; D015994:Incidence; D007558:Italy; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011184:Postoperative Period; D011379:Prognosis; D011507:Proteinuria / Q000453:epidemiology*; D012189:Retrospective Studies; D020858:Tissue and Organ Harvesting; D014180:Transplantation / Q000473:pathology; D016896:Treatment Outcome
Correlazione tra insorgenza di proteinuria precoce e decorso clinico del rene trapiantato. Esperienza di un singolo centro.