title: Effects of increasing L-lysine HCl in corn- or sorghum-soybean meal-based diets on growth performance and carcass characteristics of growing-finishing pigs.
abstract: We conducted three experiments to determine the effects of increasing L-lysine HCl in growing-finishing pig diets. Experiments 1 and 2, conducted at the Kansas State University research center, each used 360 growing-finishing pigs with initial BW of 56 and 63 kg, respectively. Dietary treatments were sorghum- (Exp. 1) or corn- (Exp. 2) soybean meal-based and consisted of a control (no L-lysine HCl) or 0.15, 0.225, and 0.30% L-lysine HCl replacing lysine provided by soybean meal. Experiment 3 was conducted in a commercial research facility using a total of 1,200 gilts with an initial BW of 29 kg. Pigs were allotted to one of eight dietary treatments fed in four phases. These consisted of a positive control diet with no added L-lysine HCl and the control diet with 0.05, 0.10, 0.15, 0.20, 0.25, and 0.30% L-lysine HCl replacing the lysine provided by soybean meal. The eighth dietary treatment was a negative control diet with no added L-lysine HCl and formulated to contain 0.10% less total lysine than the other treatments to ensure that dietary lysine was not above required levels. In Exp. 1, increasing L-lysine HCl decreased (linear, P < 0.01) ADG, feed efficiency (G:F), and percentage lean and increased (linear, P < 0.01) backfat depth. In Exp. 2, increasing L-lysine HCl decreased (quadratic, P < 0.03) ADG, G:F, and ADFI, but carcass characteristics were not affected. In Exp. 3, increasing L-lysine HCl decreased ADG (linear, P < 0.01) and G:F (quadratic P < 0.03). In all three experiments, the greatest negative responses were observed when more than 0.15% L-lysine HCl was added to the diet. Therefore, unless other synthetic amino acids are added to the diet, no more than 0.15% L-lysine HCl should replace lysine from soybean meal in a corn- or sorghum-soybean meal-based diet to avoid deficiencies of other amino acids. Based on the content of diets containing 0.15% Lysine-HCl, it appears the requirements for methionine plus cystine expressed as ratios relative to lysine are not greater than 50% during the early growing-finishing period (30 to 45 kg) and 62% during the late finishing period (90 to 120 kg) on a true digestible basis. For similar periods, the ratio requirements for threonine are not greater than 59% and 64% on a true digestible basis.
mesh_terms: D000596:Amino Acids / Q000172:deficiency; D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001823:Body Composition; D001835:Body Weight / Q000187:drug effects; D004063:Digestion; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005260:Female; D006851:Hydrochloric Acid; D008239:Lysine / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D008460:Meat / Q000592:standards*; D009751:Nutritional Requirements; D011897:Random Allocation; D013025:Glycine max; D013552:Swine / Q000254:growth & development* / Q000378:metabolism; D003313:Zea mays
chemical_list: D000596:Amino Acids; D008239:Lysine; D006851:Hydrochloric Acid