[Doppler echocardiographic evaluation of left ventricular diastolic function in patients with hypertrophic obstructive cardiomyopathy after alcohol septal ablation in acute and long-term follow up].
Left ventricular (LV) diastolic dysfunction is responsible for most clinical symptoms in hypertrophic cardiomyopathy. The left ventricular outflow tract (LVOT) obstruction has additional negative haemodynamic influence. Alcohol septal ablation reduces the LVOT gradient. CEL The aim of our study was the evaluation of acute and long-term changes of LV diastolic function after successful alcohol septal ablation.


METHODS
In 15 patients with successful reducing of LVOT gradient the LV diastolic function was assessed using Doppler echocardiography before ablation and in short and long-term follow-up.


RESULTS
Before ablation IVRT and DT were prolonged in comparison to normal values. In acute phase after ablation E/A ratio decreased from 1.19 +/- 0.36 to 0.89 +/- 0.27 (p < 0.01), but returned to baseline by the first week. In long-term follow-up there was again a significant reducing of E/A ratio (mainly due to E wave changes). IVRT was significantly shortened from 98 +/- 20 ms at baseline to 80.5 +/- 17 ms at day 7 and later. This change was stable to the end of follow-up. DT did not change significantly just after the ablation and during follow-up.


CONCLUSIONS
In the acute period after alcohol septal ablation there is an increase of LV relaxation disorders. Changes observed during long-term follow-up are difficult to interpret, but significant shortening of IVRT shows on improvement of the LV diastolic function.
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D018618:Echocardiography, Doppler, Color; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012997:Solvents / Q000627:therapeutic use*; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D014694:Ventricular Outflow Obstruction / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy
D012997:Solvents; D000431:Ethanol
Czynność rozkurczowa lewej komory oceniana echokardiografia dopplerowska u chorych z kardiomiopatia przerostowa z zawezaniem drogi odpływu po ablacji alkoholowej tetnicy septalnej w obserwacji krótko--i długoterminowej.