Effect of microcrystalline chitosan on the solubility of ibuprofen.
It was found that MCCh may be used for the enhancement of the solubility and dissolution rates of drugs. The solubility of IBA in water increased significantly (about 10-fold) when MCCh was added. Differential scanning calorimetry (DSC), powder X-ray diffractometry, and IR spectroscopy were used to confirm that salt links between the drug and MCCh occurred.
D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry*; D012995:Solubility / Q000187:drug effects
D004337:Drug Carriers; D002686:Chitin; D048271:Chitosan; D007052:Ibuprofen