Susceptibility of Danish Escherichia coli strains isolated from urinary tract infections and bacteraemia, and distribution of sul genes conferring sulphonamide resistance.
Antibiotic resistance of urinary tract pathogens has increased worldwide. Our aim was to provide information regarding resistance patterns of Escherichia coli in urinary tract infections (UTIs) and E. coli bacteraemia in Denmark. The overall resistance ranged from: ampicillin 20-47%, mecillinam 0-7%, trimethoprim 10-28%, sulfamethizole 22-47% and nitrofurantoin 0-3%. In strains with sulfamethizole MICs > 2048 mg/L, 97% carried sulI, sulII or both genes, with sulII being the most common. Among the sulI gene-positive strains, 96% were intI 1 gene positive.
D000293:Adolescent; D000328:Adult; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000235:genetics*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology; D003718:Denmark / Q000453:epidemiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008875:Middle Aged; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D013449:Sulfonamides / Q000494:pharmacology* / Q000627:therapeutic use; D014157:Transcription Factors / Q000235:genetics*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology*
D001426:Bacterial Proteins; D002352:Carrier Proteins; C090870:FZF1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C491369:Sul2 protein, bacteria; D013449:Sulfonamides; D014157:Transcription Factors