title: Sex hormone binding globulin levels in hirsute patients: the effect of combined OCs.
abstract: Sex hormone binding globulin (SHBG) has been measured using an improved ammonium-precipitation method.  SHBG has been measured in normal male and female subjects, and in hirsute subjects on and off combined oral contraceptives (OCs).  SHBG concentrations in hirsute subjects were significantly lower than those of normal female subjects (P0.001).  During treatment with OCs, SHBG concentrations rose significantly (P0.001).  Among hirsute patients, there was no significant (P0.5) difference between the pretreatment SHBG concentrations of 'responders' and those of 'nonresponders.'  During treatment, SHBG concentrations increased in both groups.
mesh_terms: D000367:Age Factors; D001695:Biology; D019411:Clinical Laboratory Techniques; D003267:Contraception; D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D004194:Disease; D004703:Endocrine System; D005040:Ethynodiol Diacetate; D005193:Family Planning Services; D006628:Hirsutism; D006728:Hormones; D008656:Mestranol; D009641:Norethynodrel; D010827:Physiology; D012816:Signs and Symptoms; D012867:Skin; D013812:Therapeutics
chemical_list: D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D006728:Hormones; D005040:Ethynodiol Diacetate; D009641:Norethynodrel; D008656:Mestranol
keywords: Age Factors; Biology; Contraception; Contraceptive Agents, Female; Contraceptive Methods--side effects; Dermatological Effects; Diseases; Endocrine System; Ethynodiol Diacetate; Family Planning; Hirsutism; Hormones--analysis; Laboratory Procedures; Mestranol; Norethynodrel; Oral Contraceptives, Combined; Oral Contraceptives--side effects; Physiology; Signs And Symptoms; Treatment