title: Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease.
abstract: Recently advances in understanding the molecular basis of Alzheimer's disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed.
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D001665:Binding Sites; D002219:Carbamates / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D000077265:Donepezil; D015195:Drug Design; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D008968:Molecular Conformation; D015394:Molecular Structure; D048448:Phenylcarbamates; D010880:Piperidines / Q000627:therapeutic use; D000068836:Rivastigmine; D013329:Structure-Activity Relationship; D013619:Tacrine / Q000627:therapeutic use
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D007189:Indans; D048448:Phenylcarbamates; D010880:Piperidines; D013619:Tacrine; D000077265:Donepezil; D000110:Acetylcholinesterase; D000068836:Rivastigmine