title: Site-directed exchange studies with combinatorial libraries of nanostructures.
abstract: We describe a new combinatorial method for studying the exchange between solution adsorbates and nanoscale features within libraries generated via dip-pen nanolithography. Four different compounds, 1-octadecanethiol, 16-mercaptohexadecanoic acid, ferrocene (11-mercaptoundecyl), and ferrocene (11-mercapto-1-oxoundecyl), are studied on amorphous and single-crystal gold substrates. This series of adsorbates allows us to compare the exchange properties of patterns of nanoscale features as a function of composition, feature size, and type of underlying substrate. Moreover, these properties can be compared and contrasted with bulk SAM properties. The novel strategy provides not only a method for initiating site-specific exchange processes but also a way of extracting kinetic information about the rate of such processes in situ.
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D005296:Ferrous Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D000075163:Metallocenes; D036103:Nanotechnology / Q000379:methods*; D010169:Palmitic Acids / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: C450319:16-mercaptohexadecanoic acid; D005296:Ferrous Compounds; D000075163:Metallocenes; D010169:Palmitic Acids; D013438:Sulfhydryl Compounds; C055360:n-octadecyl mercaptan; D006046:Gold; C004998:ferrocene