Complete recovery after 2 h of cardiopulmonary resuscitation following high-dose prostaglandin treatment for atonic uterine haemorrhage.
We report the case of a 31-year-old woman who delivered twins by Caesarean section in whom atonic uterine haemorrhage developed 6 h postoperatively. During conservative treatment with the high-dose prostaglandin analogs sulprostone (PGE(2)) and dinoprost (PGF(2alpha)), acute pulmonary oedema and cardiac decompensation developed and, subsequently, the patient suffered cardiopulmonary arrest. After a 2h-period of cardiopulmonary resuscitation (CPR), it was possible to restore and stabilize circulation under the highest dose of catecholamines. Despite 2h of CPR, the patient was discharged from hospital 3 months later without any major physical or neurocognitive deficit.
D000328:Adult; D016887:Cardiopulmonary Resuscitation; D002585:Cesarean Section / Q000009:adverse effects*; D015237:Dinoprost / Q000008:administration & dosage / Q000009:adverse effects*; D015232:Dinoprostone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006323:Heart Arrest / Q000628:therapy*; D006333:Heart Failure / Q000139:chemically induced / Q000628:therapy; D006336:Heart Massage; D006801:Humans; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects; D019106:Postoperative Hemorrhage / Q000188:drug therapy*; D011247:Pregnancy; D011654:Pulmonary Edema / Q000139:chemically induced / Q000628:therapy; D014590:Uterine Contraction / Q000187:drug effects*; D014592:Uterine Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy
D010120:Oxytocics; C016767:sulprostone; D015237:Dinoprost; D015232:Dinoprostone