Toward bioengineering anticancer drugs.
The biosynthetic route for enediyne production remained mysterious until two independent groups recently reported the genes that orchestrate enediyne synthesis in two different microorganisms. These discoveries lay the foundations for engineering this pathway to generate improved anticancer drugs.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry*; D001698:Biomedical Engineering / Q000379:methods*; D015195:Drug Design; D053281:Enediynes; D016937:Gram-Positive Endospore-Forming Rods / Q000737:chemistry / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; D009097:Multienzyme Complexes; C058024:C 1027; D006899:Mixed Function Oxygenases