title: Biomechanical response of the cornea to phototherapeutic keratectomy when treated as a fluid-filled porous material.
abstract: OBJECTIVE
  Surgical effect on corneal deformation has been traditionally analyzed based on the solid material assumption. We examine the validity of this assumption by treating the cornea as a fluid-filled porous material and separately modeling the solid and fluid constituents inside the cornea. In particular, the internal sub-atmospheric fluid pressure is treated as an important part of the mechanical loading in addition to the intraocular pressure.
  
  
  METHODS
  Finite element simulations of phototherapeutic keratectomy (PTK) were conducted with the cornea treated as a fluid-filled porous material, and through-the-thickness difference in swelling phenomena was taken into account. The results were compared with the same PTK simulations based on the solid material assumption of the cornea.
  
  
  RESULTS
  The PTK simulation results based on the fluid-filled porous material assumption demonstrated a significantly higher amount of unintended hyperopic shift compared to the results based on the traditional solid material assumption. The proposed approach qualitatively matched experimental observations.
  
  
  CONCLUSIONS
  The internal sub-atmospheric pressure significantly influenced corneal deformation. The simulation results based on the fluid-filled porous material assumption raise serious questions regarding the validity of existing models in corneal surgery, where the effect of the internal sub-atmospheric pressure on corneal deformations is neglected.
mesh_terms: D001696:Biomechanical Phenomena; D003315:Cornea / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D054018:Lasers, Excimer; D008954:Models, Biological; D018903:Photorefractive Keratectomy; D016062:Porosity; D012030:Refractive Errors / Q000503:physiopathology*; D054140:Refractive Surgical Procedures