Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma.
Hodgkin's lymphoma (HL) is characterized by a few Hodgkin, Reed-Sternberg cells (HRS) surrounded by benign cells. We recently reported that mast cells were the predominant CD30L-positive cells in HL tumours, and that they activate HRS in vitro through CD30L-CD30 interaction. Here, we investigated the clinical importance of mast cell infiltration in the tumours of 123 patients. Tumour specimens were stained with a mast-cell-specific antibody that detects tryptase. Mast cells were detected in virtually every case and increasing numbers of mast cells correlated to nodular sclerosis histology (P = 0.008). Patients with higher mast cell infiltration had a worse relapse-free survival (P = 0.01).
D053285:CD30 Ligand; D018572:Disease-Free Survival; D005260:Female; D006689:Hodgkin Disease / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000201:enzymology / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism; D053802:Tryptases
D053285:CD30 Ligand; D017730:Ki-1 Antigen; D008562:Membrane Glycoproteins; C505774:TNFSF8 protein, human; D012697:Serine Endopeptidases; D053802:Tryptases