title: Centrosomal TACCtics.
abstract: Although the centrosome was first described over 100 years ago, we still know relatively little of the molecular mechanisms responsible for its functions. Recently, members of a novel family of centrosomal proteins have been identified in a wide variety of organisms. The transforming acidic coiled-coil-containing (TACC) proteins all appear to play important roles in cell division and cellular organisation in both embryonic and somatic systems. These closely related molecules have been implicated in microtubule stabilisation, acentrosomal spindle assembly, translational regulation, haematopoietic development and cancer progression. In this review, I summarise what we already know of this protein family and will use the TACC proteins to illustrate the many facets that centrosomes have developed during the course of evolution.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018385:Centrosome / Q000737:chemistry* / Q000502:physiology*; D004330:Drosophila; D029721:Drosophila Proteins; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000737:chemistry*; D008938:Mitosis; D008954:Models, Biological; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D014981:Xenopus
chemical_list: D029721:Drosophila Proteins; D008869:Microtubule-Associated Proteins; C404402:TACC protein, Drosophila