The Plasmodium falciparum genome--a blueprint for erythrocyte invasion.
Erythrocyte invasion by Plasmodium falciparum involves multiple ligand-receptor interactions and numerous apparent redundancies. The genome sequence of this parasite reveals new gene families encoding proteins that appear to mediate erythrocyte invasion.
D000818:Animals; D004910:Erythrocyte Membrane / Q000469:parasitology / Q000648:ultrastructure; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology*; D019143:Evolution, Molecular; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D006801:Humans; D008024:Ligands; D017780:Malaria Vaccines; D020066:Merozoite Surface Protein 1 / Q000737:chemistry / Q000378:metabolism; D005810:Multigene Family; D010961:Plasmodium / Q000472:pathogenicity / Q000502:physiology; D010963:Plasmodium falciparum / Q000235:genetics* / Q000472:pathogenicity* / Q000502:physiology / Q000648:ultrastructure; D017434:Protein Structure, Tertiary; D015800:Protozoan Proteins / Q000737:chemistry / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D019108:Tight Junctions / Q000648:ultrastructure
D008024:Ligands; D017780:Malaria Vaccines; D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface