Microtubule capture: IQGAP and CLIP-170 expand the repertoire.
Rho GTPases regulate microtubule capture near the cell cortex to polarize cells. What is surprising is the repertoire of interactions between proteins at the ends of microtubules and their cortical targets. The microtubule tip protein CLIP-170 has now been found to interact with the Cdc42/Rac effector IQGAP and mediate transient capture of microtubules.
D008840:Microfilament Proteins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism*; D009363:Neoplasm Proteins; D020703:ras GTPase-Activating Proteins; D020741:rho GTP-Binding Proteins / Q000378:metabolism
C101203:IQ motif containing GTPase activating protein 1; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D020703:ras GTPase-Activating Proteins; C076744:cytoplasmic linker protein 170; D020741:rho GTP-Binding Proteins