Fluconazole-carbamazepine interaction.
The patient we describe had elevated carbamazepine serum concentrations during concomitant fluconazole administration (400 mg/day), including serial concentrations both before and after antifungal therapy. Since fluconazole is a known inhibitor of the cytochrome P450 enzyme system, this suggests an inhibition of carbamazepine metabolism.
D000328:Adult; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D002220:Carbamazepine / Q000493:pharmacokinetics*; D004357:Drug Synergism; D015725:Fluconazole / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male
D000927:Anticonvulsants; D000935:Antifungal Agents; D002220:Carbamazepine; D015725:Fluconazole