Quinoline alkaloids and anti-platelet aggregation constituents from the leaves of Melicope semecarpifolia.
Three new quinoline alkaloids, melisemine, confusadine, and melicarpinone, together with twelve known compounds have been isolated from the leaves of Melicope semecarpifolia. The structures of these three compounds were determined through spectral analyses. Confusadine was demonstrated to be an anti-platelet aggregation constituent.
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000097:blood / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D027821:Rutaceae; D013917:Thrombin / Q000494:pharmacology
D000470:Alkaloids; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D011804:Quinolines; C469291:confusadine; C469292:melicarpinone; C469290:melisemine; D016718:Arachidonic Acid; D003094:Collagen; D013917:Thrombin