Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films.
BACKGROUND
Besides enhancing healing, an ideal dressing should prevent invasion of pathogens and control the number of bacteria already present in the wounds.


OBJECTIVE
To evaluate the barrier and antimicrobial properties of a cyanoacrylate-based bandage (LAB) against Staphylococcus aureus or Pseudomonas aeruginosa on partial thickness wounds in swine.


METHODS
Barrier study: Bacteria were inoculated over test materials (LAB, standard bandage, air-exposed) that were placed over wounds. The bacteria from wounds were quantitated at 24, 48, and 72 hours postinoculation. Antimicrobial study: Wounds inoculated with bacteria were covered with LAB, standard bandage, or hydrocolloid bandage or left air-exposed. The bacteria recovered from wounds were quantitated at 24 and 72 hours after treatment.


RESULTS
Barrier study: No bacteria were recovered from LAB-treated wounds. Antimicrobial study: LAB reduced the number of inoculated bacteria in comparison to all other groups.


CONCLUSIONS
LAB is effective in protecting wounds from external bacterial invasion and reducing bacterial contamination.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena; D003487:Cyanoacrylates / Q000494:pharmacology*; D005260:Female; D023421:Models, Animal; D009779:Occlusive Dressings / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013552:Swine; D014014:Tissue Adhesives / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate