Application of imiquimod by suppositories (anal tampons) efficiently prevents recurrences after ablation of anal canal condyloma.
BACKGROUND
After surgical removal, anal canal condyloma (ACC) has a higher risk of recurrence compared with extragenital warts.


OBJECTIVE
To reduce local recurrences of ACC using follow-up treatment with imiquimod-containing suppositories (anal tampons).


METHODS
After ablation of ACC, 10 male patients received treatment with imiquimod suppositories three times weekly for 3-4 months.


RESULTS
Treatment with imiquimod anal tampons was well tolerated. Early initial recurrences in some patients cleared after treatment with the imiquimod suppositories. Within a mean follow-up of 9 months no patient demonstrated recurrence of ACC.


CONCLUSIONS
These data suggest that imiquimod anal tampons may represent a new therapeutic option to prevent recurrences of ACC following ablative surgery.
D000328:Adult; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000627:therapeutic use; D001004:Anus Diseases / Q000517:prevention & control* / Q000601:surgery; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000517:prevention & control* / Q000601:surgery; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D007369:Interferon Inducers / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D055502:Secondary Prevention; D013488:Suppositories
D000634:Aminoquinolines; D007369:Interferon Inducers; D013488:Suppositories; D000077271:Imiquimod