title: Evaluation of gemeprost vaginal pessaries in the termination of abnormal intra-uterine pregnancies at twelve teaching hospitals in Indonesia.
abstract: Vaginal pessaries, up to a maximum of 5, each containing 1 mg of 16,16-dimethyl-trans-delta squared-prostaglandin E1, ester (Gemeprost) were inserted as high as possible into the posterior fornix of the vagina at 3 hourly intervals in 459 women with abnormal intrauterine pregnancies presenting for termination of the pregnancy.  There were 145 missed abortions (31.6%), 207 intrauterine fetal deaths (45.1%), 86 molar pregnancies (18.7%), 5 anencephalics (1.1%), and 16 others (3.5%).  The study was conducted from July 1981-March 1982.  402 women (87.6%) underwent abortion within the 30 hour observation period, including 139 women (30.3%) who required additional procedures to complete evacuation of the uterus.  Expulsion of the uterine contents failed to occur within 30 hours in 57 women (12.4%) and alternative procedures were employed.  These failures consisted of 37 missed abortions, 17 intrauterine fetal deaths, 2 molar pregnancies, and 1 pregnancy with an IUD in situ.  Side effects caused by the drug were basically tolerable.  234 women (51.0%) had 1 or more side effects, gastrointestinal tract disturbances (nausea, vomiting, and diarrhea) being the most frequently observed, and moderate fever the next most frequent.  There was 1 ruptured uterus.
mesh_terms: D000028:Abortion, Induced; D001208:Asia; D001210:Asia, Southeastern; D001695:Biology; D002264:Carboxylic Acids; D055598:Chemical Phenomena; D002621:Chemistry; D003710:Demography; D003906:Developing Countries; D004194:Disease; D004703:Endocrine System; D005069:Evaluation Studies as Topic; D005193:Family Planning Services; D005313:Fetal Death; D007214:Indonesia; D009026:Mortality; D009930:Organic Chemicals; D010827:Physiology; D011157:Population Dynamics; D011247:Pregnancy; D011248:Pregnancy Complications; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011453:Prostaglandins; D012098:Reproduction
chemical_list: D002264:Carboxylic Acids; D009930:Organic Chemicals; D011453:Prostaglandins
keywords: Abortion, Induced; Asia; Biology; Carboxylic Acids; Demographic Factors; Developing Countries; Diseases; Endocrine System; Evaluation; Family Planning; Fertility Control, Postconception; Fetal Death; Indonesia; Ingredients And Chemicals; Mortality; Organic Chemicals; Physiology; Population Dynamics; Pregnancy; Pregnancy Complications; Pregnancy, Second Trimester; Pregnancy, Third Trimester; Prostaglandins--administraction and dosage; Prostaglandins--side effects; Reproduction; Southeastern Asia