title: Mural folliculitis and alopecia caused by infection with goat-associated malignant catarrhal fever virus in two sika deer.
abstract: Two sika deer from a zoo in Florida were examined because of chronic hair loss and skin lesions. No common causes of alopecia were identified in either deer. One deer was treated with prednisone, but the condition worsened when the dosage was decreased. Both deer were euthanatized after several months because of continued disease. The predominant histologic lesion in skin specimens was granulomatous mural folliculitis. Serologic testing and sequencing of fragments produced with a consensus polymerase chain reaction assay indicated that both deer were infected with caprine herpesvirus-2, a newly recognized member of the malignant catarrhal fever group of viruses. Disease in these deer was substantially different from that typically seen following infection with ovine herpesvirus-2, the sheep-associated malignant catarrhal fever virus. Findings in these deer establish the pathogenicity of caprine herpesvirus-2 in sika deer and illustrate the ability of this group of complex herpesviruses to cause a wide variety of clinical abnormalities in diverse species.
mesh_terms: D000505:Alopecia / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D000818:Animals; D000836:Animals, Zoo; D004279:DNA, Viral / Q000032:analysis; D003670:Deer; D005260:Female; D005499:Folliculitis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D018142:Gammaherpesvirinae / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D015511:Goat Diseases / Q000635:transmission / Q000821:virology*; D006041:Goats; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary / Q000821:virology; D008304:Malignant Catarrh / Q000175:diagnosis* / Q000473:pathology / Q000635:transmission; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012867:Skin / Q000473:pathology; D013045:Species Specificity
chemical_list: D004279:DNA, Viral