Low-dose lamotrigine in West syndrome.
Three infants affected with symptomatic West syndrome (WS), unresponsive to gamma-vinyl-GABA and to ACTH (first line drugs for WS), were rapidly cured with very small doses of lamotrigine (LTG). This suggests the advisability of a trial with low-dose LTG, at least in symptomatic WS resistant to one or two first line drugs. Moreover, it may be of speculative interest as regards pathogenetic mechanisms in some cases of WS.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D000077213:Lamotrigine; D008279:Magnetic Resonance Imaging; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy*; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*; D020888:Vigabatrin / Q000627:therapeutic use
D000927:Anticonvulsants; D014227:Triazines; D000324:Adrenocorticotropic Hormone; D020888:Vigabatrin; D000077213:Lamotrigine