[Experience in treating patients with chronic obstructive bronchitis with fenspirid].
OBJECTIVE
To study a clinical effect of fenspirid and its impact on external respiration function in patients with chronic obstructive bronchitis (COB) in the exacerbation phase.


METHODS
30 COB patients participated in the trial (20 males, 10 females, age 39-80 years). The severity of clinical symptoms (cough, sputum, dyspnea) was studied using special scales. External respiration function was examined by a spirometric system "Tamrac system spiro sense Y2 14". Fenspirid treatment was conducted in a dose 80 mg twice a day for 3 months. Control examinations were made 2 weeks, 1 and 3 months after the treatment start.


RESULTS
A 3-month treatment with fenspirid resulted in regression of COB symptoms: cough and sputum ceased, dyspnea decreased. This led to improvement in external respiration function, especially in patients with mixed ventilatory disorders with prevailing restriction.


CONCLUSIONS
Fenspirid is an effective and well tolerated treatment of chronic obstructive bronchitis.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001991:Bronchitis / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013141:Spiro Compounds / Q000627:therapeutic use*; D013147:Spirometry
D013141:Spiro Compounds; C084775:fenspiride
Opyt lecheniia fenspiridom bol'nykh khronicheskim obstruktivnym bronkhitom.