[The use of nitroglycerin as nitric oxide donor for treatment of preterm labour].
OBJECTIVE
The aim of this study was the analysis of the effectiveness and safety of glyceryl trinitrate as a nitric oxide donor for treatment of preterm labour.


METHODS
The study was carried out on 50 patients in preterm labour between 28 and 34 weeks of gestation receiving transdermal glyceryl trinitrate (GTN) patches (drug Nitroderm TTS 5 produced by Novartis Pharma AG, Bazylea).


RESULTS
GTN patches appear to be a non-invasive method of suppressing uterine contractions in preterm labour. MAP and systolic blood pressure decreased significantly during the use of nitroglycerin. Diastolic blood pressure and maternal heart rate did not change during the treatment. Neither were significant changes in fetal heart rate or in fetal cardiotocographic recordings detected during or after the treatment.


CONCLUSIONS
Transdermal glyceryl trinitrate (5 mg/day) may be promising as a safe and effective drug for treatment of preterm labour, especially in patients with higher blood pressure.
D000279:Administration, Cutaneous; D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D020030:Nitric Oxide Donors / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000188:drug therapy* / Q000517:prevention & control*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D015149:Tocolytic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014590:Uterine Contraction / Q000187:drug effects
D020030:Nitric Oxide Donors; D015149:Tocolytic Agents; D005996:Nitroglycerin
Wykorzystanie nitrogliceryny jako dawcy tlenku azotu w leczeniu zagrazajacego porodu przedwczesnego.