title: High-speed microwave-promoted hetero-Diels-Alder reactions of 2(1H)-pyrazinones in ionic liquid doped solvents.
abstract: Inter- and intramolecular hetero-Diels-Alder reactions in a series of functionalized 2(1H)-pyrazinones were investigated under controlled microwave irradiation. The cycloaddition reactions were efficiently performed in sealed tubes, utilizing either a combination of 1,2-dichloroethane and a thermally stable ionic liquid, or 1,2-dichlorobenzene as reaction medium. In all cases, a significant rate-enhancement using microwave flash heating as compared to thermal heating was observed.
authors.affiliation: Laboratory for Organic Synthesis, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Heverlee, Belgium. vandereycken@chem.kuleuven.ac.be
authors.forename: Erik
authors.initials: E
authors.lastname: Van Der Eycken
authors.forename: Prasad
authors.initials: P
authors.lastname: Appukkuttan
authors.forename: Wim
authors.initials: W
authors.lastname: De Borggraeve
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen
authors.forename: Doris
authors.initials: D
authors.lastname: Dallinger
authors.forename: C Oliver
authors.initials: CO
authors.lastname: Kappe