Hypertriglyceridemia and risk of coronary heart disease.
Mounting evidence indicates that elevated triglyceride level is a risk factor for coronary heart disease (CHD). The role of triglyceride as a causative agent for CHD is less clear. Hypertriglyceridemia is frequently associated with a set of complex metabolic abnormalities, including low high-density lipoprotein cholesterol, small dense low-density lipoprotein, central obesity, insulin resistance, and type 2 diabetes. Understanding the physiologic processes that lead to the metabolic disturbances associated with hypertriglyceridemia is essential in investigating the effect of triglyceride on CHD risk.
Hokanson
John E
JE
Department of Preventive Medicine & Biometrics, University of Colorado Health Sciences Center, Box B119, 4200 East 9th Avenue, Denver, CO 80262, USA. john.hokanson@UCHSC.edu
D015897:Comorbidity; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology* / Q000503:physiopathology; D008074:Lipoproteins / Q000097:blood / Q000502:physiology; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors
D008074:Lipoproteins