Neuroinflammation in Alzheimer's disease and prion disease.
Alzheimer's disease (AD) and prion disease are characterized neuropathologically by extracellular deposits of Abeta and PrP amyloid fibrils, respectively. In both disorders, these cerebral amyloid deposits are co-localized with a broad variety of inflammation-related proteins (complement factors, acute-phase protein, pro-inflammatory cytokines) and clusters of activated microglia. The present data suggest that the cerebral Abeta and PrP deposits are closely associated with a locally induced, non-immune-mediated chronic inflammatory response. Epidemiological studies indicate that polymorphisms of certain cytokines and acute-phase proteins, which are associated with Abeta plaques, are genetic risk factors for AD. Transgenic mice studies have established the role of amyloid associated acute-phase proteins in Alzheimer amyloid formation. In contrast to AD, there is a lack of evidence that cytokines and acute-phase proteins can influence disease progression in prion disease. Clinicopathological and neuroradiological studies have shown that activation of microglia is a relatively early pathogenetic event that precedes the process of neuropil destruction in AD patients. It has also been found that the onset of microglial activation coincided in mouse models of prion disease with the earliest changes in neuronal morphology, many weeks before neuronal loss and subsequent clinical signs of disease. In the present work, we review the similarities and differences between the involvement of inflammatory mechanisms in AD and prion disease. We also discuss the concept that the demonstration of a chronic inflammatory-like process relatively early in the pathological cascade of both diseases suggests potential therapeutic strategies to prevent or to retard these chronic neurodegenerative disorders.
Eikelenboom
P
P
Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.|Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
Bate
C
C
Department of Veterinary Pathology, Institute of Comparative Medicine, Glasgow University Veterinary School,. Glasgow, Scotland.
Van Gool
W A
WA
Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
Hoozemans
J J M
JJM
Department of Pathology, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
Rozemuller
J M
JM
Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.
Veerhuis
R
R
Department of Pathology, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
Williams
A
A
Department of Veterinary Pathology, Institute of Comparative Medicine, Glasgow University Veterinary School,. Glasgow, Scotland.
D000209:Acute-Phase Proteins / Q000276:immunology; D000544:Alzheimer Disease / Q000150:complications / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000276:immunology; D018450:Disease Progression; D004660:Encephalitis / Q000150:complications / Q000276:immunology*; D006801:Humans; D017628:Microglia / Q000276:immunology; D017096:Prion Diseases / Q000150:complications / Q000276:immunology*
D000209:Acute-Phase Proteins; D016207:Cytokines