title: Nutrition and growth in cystic fibrosis.
abstract: Malnutrition is a common complication of chronic diseases in children and may lead to growth impairment (stunting). Malnutrition in cystic fibrosis (CF) results from increased energy expenditure, decreased energy intakes, malabsorption of ingested nutrients because of pancreatic insufficiency and chronic inflammation. Malnutrition and high levels of inflammatory cytokines affect IGF-1 production through interrelated mechanisms. Nutritional support was shown to improve both nutritional status and outcome in CF. However, some nutrients have a direct effect on the disease. n-3 fatty acids supplementation is able to correct lipid abnormalities resulting from a primary mechanism. Moreover, n-3 fatty acids have a direct effect on the inflammatory response, decreasing eicosanoid synthesis and modulating nuclear transcriptional factors nuclear factor kappaB and peroxisome proliferator-activated receptors gamma. Nutritional support may be considered part of the care of the CF patient together with antibiotics, pancreatic enzymes and physiotherapy, influencing significantly the evolution of the disease.
authors.affiliation: Clinical Investigation Unit, Robert Debré Hospital, Paris, France. regis.hankard@rdb.ap-hop-paris.fr
authors.forename: Régis
authors.initials: R
authors.lastname: Hankard
authors.forename: Anne
authors.initials: A
authors.lastname: Munck
authors.forename: Jean
authors.initials: J
authors.lastname: Navarro
mesh_terms: D000818:Animals; D003550:Cystic Fibrosis / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D016207:Cytokines; D002149:Energy Intake; D004734:Energy Metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D006128:Growth; D006801:Humans; D007249:Inflammation / Q000150:complications; D008286:Malabsorption Syndromes; D009748:Nutrition Disorders / Q000209:etiology; D009752:Nutritional Status; D018529:Nutritional Support
chemical_list: D016207:Cytokines; D015525:Fatty Acids, Omega-3