title: Bone histomorphometric evaluation of a clinically fused titanium tumour cage in a child.
abstract: An intervertebral titanium tumour cage was implanted in a 2-year-old-girl after T11 spondylectomy due to Ewing sarcoma. After 2-years' follow-up without evidence of recurrence, the titanium cage was explanted to correct spinal deformity and to allow normal spinal growth development. Radiological follow-up and surgical exploration at the time of retrieval suggested fusion of the segment. Histologic evaluation, however, demonstrated ingrowth of trabecular bone, but without bridging trabecular bone. The distance between the opposing bone fronts measured 1.5 mm and the viable bone volume (BV/TV) within the cage was 36%. Histologic evaluation demonstrated that bone formation was still an ongoing process in the fusion zone 2 years after implantation.
authors.affiliation: Department of Orthopaedic Surgery, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: van Dijk
authors.forename: Th H
authors.initials: TH
authors.lastname: Smit
authors.forename: E H
authors.initials: EH
authors.lastname: Burger
authors.forename: P I M J
authors.initials: PI
authors.lastname: Wuisman
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D016268:Internal Fixators / Q000592:standards* / Q000639:trends; D008279:Magnetic Resonance Imaging; D010012:Osteogenesis / Q000502:physiology; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D011859:Radiography; D012512:Sarcoma, Ewing / Q000601:surgery*; D013117:Spinal Cord Compression / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D013123:Spinal Fusion / Q000295:instrumentation* / Q000379:methods; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014025:Titanium / Q000592:standards / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: D014025:Titanium