Autofluorescence and 5-aminolevulinic acid induced fluorescence diagnosis of penile carcinoma -- new techniques to monitor Nd:YAG laser therapy.
Nd:YAG laser coagulation is possible for superficial tumors of the penis. The value of photodynamic diagnosis (PDD) and autofluorescence imaging (AF) in detecting malignant lesions on the penis was evaluated. Twelve patients with biopsy-confirmed squamous cell cancer (SCC) of the penis were examined with PDD and AF. For the PDD and AF the penis was illuminated with the blue excitation light from a xenon arch lamp. Biopsies were taken from suspicious lesions detected by PDD or AF and then treated with Nd:YAG laser coagulation. Neoplastic lesions presented with a positive red fluorescence under PDD or a diminished appearance under AF. The HPV-analysis was positive in eight of the 12 lesions. Fluorescence diagnosis is used for the detection of neoplastic lesions. It assists the urologist in detecting neoplastic and preneoplastic lesions, ensuring a more reliable destruction of all tumor material in penile sparing surgery.
Frimberger
Dominic
D
Department of Urology, University of Munich-Grosshadern, Ludwig-Maximilians-University, Marchioninistr 15, 81377 Munich, Germany. Dominic.Frimberger@uro.med.uni-muenchen.de
Schneede
Peter
P
Hungerhuber
Edwin
E
Sroka
Ronald
R
Zaak
Dirk
D
Siebels
Michael
M
Hofstetter
Alfons
A
D000368:Aged; D000622:Aminolevulinic Acid; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000601:surgery* / Q000821:virology; D003949:Diagnostic Techniques, Surgical; D005453:Fluorescence; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D010412:Penile Neoplasms / Q000175:diagnosis* / Q000601:surgery* / Q000821:virology; D017319:Photosensitizing Agents; D010865:Pilot Projects
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid