title: A reference database for tumor-related genes co-expressed with interleukin-8 using genome-scale in silico analysis.
abstract: BACKGROUND
  The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8.
  
  
  RESULTS
  IL-8 is represented in 53 dbEST cDNA libraries. We calculated the frequency of occurrence of all the genes represented in these cDNA libraries, and ranked the candidates based on a Z-score. Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries.
  
  
  CONCLUSIONS
  This method generated a reference database for genes co-expressed with IL-8 and could facilitate further characterization of functional association among genes.
authors.affiliation: Discovery Technology Department, Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. lawrence.benbow@spcorp.com
authors.forename: Lawrence
authors.initials: L
authors.lastname: Benbow
authors.forename: Lynn
authors.initials: L
authors.lastname: Wang
authors.forename: Maureen
authors.initials: M
authors.lastname: Laverty
authors.forename: Suxing
authors.initials: S
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Qiu
authors.forename: Richard W
authors.initials: RW
authors.lastname: Bond
authors.forename: Eric
authors.initials: E
authors.lastname: Gustafson
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hedrick
authors.forename: Mitchell
authors.initials: M
authors.lastname: Kostich
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Greene
authors.forename: Luquan
authors.initials: L
authors.lastname: Wang