Distribution of the CCR5 gene 32-basepair deletion in 11 Chinese populations.
A mutant allele of the chemokine receptor gene CCR5 bearing a 32-basepair deletion (delta 32CCR5) could increase the resistance to HIV-1 infection or delayed progression to AIDS. The frequency of this mutation is higher in Europeans than in Asians. To investigate the distribution of this polymorphism in China, 715 individuals from 11 Chinese populations were screened by PCR, including the Han and 10 other ethnic groups. The delta 32CCR5 gene was found in 16 individuals from 5 ethnic groups. All of them were heterozygous. The frequency of the mutant alleles of delta 32CCR5 is low in China and reflects (or might reflect) ancestral gene flow from Europe to Chinese ethnic groups and recent intermarriage within the ethnic groups.
Zhang
Chunyu
C
Department of Medical Genetics, Harbin Medical University, Harbin, China.
Fu
Songbin
S
Xue
Yali
Y
Wang
Qi
Q
Huang
Xiaoyi
X
Wang
Baiqiu
B
Liu
An
A
Ma
Linlin
L
Yu
Yang
Y
Shi
Rongqian
R
Lv
Fuqu
F
Shi
Zhongcheng
Z
Zhang
Yu
Y
Cheng
Wenhong
W
Ai
Qionghua
Q
Xu
Fang
F
Huang
Chengbin
C
Chen
Baibin
B
Kang
Xianghua
X
Sun
Yanyang
Y
Zhang
Guiyin
G
Li
Pu
P
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics; D000483:Alleles; D044466:Asian People; D020029:Base Pairing / Q000235:genetics*; D002681:China; D002872:Chromosome Deletion; D018450:Disease Progression; D005787:Gene Frequency / Q000235:genetics*; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005828:Genetics, Population; D015658:HIV Infections / Q000235:genetics; D015497:HIV-1; D006801:Humans; D009154:Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D019713:Receptors, CCR5 / Q000235:genetics*
D019713:Receptors, CCR5