title: Autoimmune enteropathy in an adult with autoimmune multisystemic involvement.
abstract: We describe the case of a 58-year-old woman with autoimmune enteropathy associated with thyroiditis, gastritis, transitory neutropenia, sicca syndrome and severe axonal polyneuropathy of autoimmune origin. Enterocyte autoantibodies were not detected. However, predisposition to autoimmune disease was indicated by the presence of high titres of anti-gastric parietal cell, anti-thyroglobulin, anti-thyroid peroxidase and anti-neutrophil antibodies. CD4+ and CD8+ lymphocytes were equally distributed in the lamina propria of the small intestine, but CD8+ cells were highly represented among intraepithelial lymphocytes.
authors.affiliation: Dept of Gastroenterology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Casis
authors.forename: I
authors.initials: I
authors.lastname: Fernández-Vázquez
authors.forename: E
authors.initials: E
authors.lastname: Barnardos
authors.forename: A
authors.initials: A
authors.lastname: Saiz
authors.forename: C
authors.initials: C
authors.lastname: Ballestín
authors.forename: J D
authors.initials: JD
authors.lastname: Morillas
authors.forename: F
authors.initials: F
authors.lastname: Colina
authors.forename: J A
authors.initials: JA
authors.lastname: Solís-Herruzo
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003967:Diarrhea / Q000150:complications; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008286:Malabsorption Syndromes / Q000150:complications; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications; D011115:Polyneuropathies / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D005938:Glucocorticoids; D011239:Prednisolone