title: Role of mitochondrial dysfunction in Alzheimer's disease.
abstract: Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.
authors.affiliation: Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. rjc8@po.cwru.edu
authors.forename: Rudy
authors.initials: R
authors.lastname: Castellani
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hirai
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Drew
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nunomura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
authors.forename: Adam D
authors.initials: AD
authors.lastname: Cash
authors.forename: Mark E
authors.initials: ME
authors.lastname: Obrenovich
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003580:Cytochromes / Q000172:deficiency / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D028361:Mitochondrial Diseases / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D003580:Cytochromes; D004272:DNA, Mitochondrial