[Olanzapine improves chorea in patients with Huntington's disease].
BACKGROUND
The main treatment for choreatic movements associated to Huntington s disease are the neuroleptic drugs, however, its use causes long term troubles.


METHODS
We describe two patients with a predominantly choreic Huntington s disease, who experience improvement of choreatic movements after introduction of olanzapine to their treatment, being this drug well tolerated.


CONCLUSIONS
The improvement of chorea suggests that olanzapine has a dopaminergic D2 receptors blocking action.
Jiménez-Jiménez
F J
FJ
Servicio de Nurología, Hospital Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España. fjimenezj@meditex.es
de Toledo
M
M
Puertas
I
I
Barón
M
M
Zurdo
M
M
Barcenilla
B
B
D001569:Benzodiazepines; D002819:Chorea / Q000188:drug therapy* / Q000209:etiology; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D065127:Dopamine D2 Receptor Antagonists; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D001569:Benzodiazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D000077152:Olanzapine; D010890:Pirenzepine; D017367:Selective Serotonin Reuptake Inhibitors