title: Liver metastases from breast cancer. Results of surgical resection.
abstract: OBJECTIVE
  Purpose of this study is to define the effectiveness of surgical resection of liver metastases from operated breast cancer.
  
  
  METHODS
  Nineteen patients underwent surgical exploration to resect liver metastases from previously operated breast carcinoma. Seventeen patients were resected: 15 patients had unique metastases and were submitted to a wedge liver resection while 2 had multiple lesions; in these cases a V-VI segmentectomy and a right hepatectomy was required. After liver resection 11 patients received chemotherapy, 2 chemotherapy plus hormone therapy, 2 hormone therapy alone and in the remaining 2 no adjuvant treatment was done.
  
  
  RESULTS
  Postoperative mortality was nil and morbidity consisted of 1 subphrenic abscess and 1 pleural effusion. Actuarial 5-year survival rate was 46%. Eight patients are still alive, 7 of whom are disease-free. Nine patients died for neoplastic progression.
  
  
  CONCLUSIONS
  Surgical resection of liver metastases from breast cancer seems to be able to improve long-term survival in selected patients with unique and isolated lesions especially in association to systemic chemotherapy and hormone therapy.
authors.affiliation: Department of Surgery, Division of Digestive Surgery and Liver Transplant, Regina Elena Institute for Cancer Research, Rome, Italy. maxcarlini@tiscali.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Carlini
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Lonardo
authors.forename: Fabio
authors.initials: F
authors.lastname: Carboni
authors.forename: Marija
authors.initials: M
authors.lastname: Petric
authors.forename: Carlo
authors.initials: C
authors.lastname: Vitucci
authors.forename: Roberto
authors.initials: R
authors.lastname: Santoro
authors.forename: Pasquale
authors.initials: P
authors.lastname: Lepiane
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Ettorre
authors.forename: Eugenio
authors.initials: E
authors.lastname: Santoro
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome