title: Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture.
abstract: The cDNA encoding human heme-regulated eukaryotic initiation factor-2 alpha (eIF-2 alpha) kinase was cloned from a human bone marrow culture. Its deduced amino acid sequence comprised of 629 amino acids with a calculated molecular weight of 71,031 Da. RT-PCR analysis revealed that the gene was also expressed in heart, kidney, spleen, muscle, and stomach.
authors.affiliation: Department of Chemical Engineering, University of Rochester, 206 Gavett Hall, Rochester, New York 14627-0166, USA.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Omasa
authors.forename: Yi-Guang
authors.initials: YG
authors.lastname: Chen
authors.forename: Athanasios
authors.initials: A
authors.lastname: Mantalaris
authors.forename: Ying-Chuech
authors.initials: YC
authors.lastname: Tsai
authors.forename: J H David
authors.initials: JH
authors.lastname: Wu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001854:Bone Marrow Cells; D003001:Cloning, Molecular; D017124:Conserved Sequence; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011817:Rabbits; D051381:Rats; D016415:Sequence Alignment; D019892:eIF-2 Kinase / Q000235:genetics*
chemical_list: D019892:eIF-2 Kinase