Comparison of tc-99m depreotide and in-111 octreotide in recurrent meningioma.
OBJECTIVE
For more than a decade, In-111 octreotide has been known to accumulate in meningiomas as a result of the expression of subtype 2 somatostatin receptors. Improved imaging characteristics can be expected with the recently developed radiotracer Tc-99m depreotide, which also binds to subtype 2 somatostatin receptors.


METHODS
The authors examined a patient with intraorbital and extracranial recurrent meningioma using SPECT with Tc-99m depreotide and In-111 octreotide. The tumor-to-background ratios in the lesions were compared and the findings were correlated with histopathologic findings.


RESULTS
Although the tumor-to-background ratios were higher for the In-111-labeled tracer in the largest tumor lesion (5.7 versus 3.3), SPECT with the Tc-99m-labeled compound showed a proved second site of recurrence as a result of the better resolution that can be achieved with that isotope. CONCLUSIONS SPECT: with Tc-99m depreotide appears to be clinically useful for detecting recurrent meningiomas with higher resolution and may outperform In-111 octreotide imaging in patients with meningiomas.
Hellwig
Dirk
D
Department of Nuclear Medicine, Saarland University Medical School, Homburg-Saar, Germany. Dirk.Hellwig@uniklinik-saarland.de
Samnick
Samuel
S
Reif
Johannes
J
Romeike
Bernd F M
BF
Reith
Wolfgang
W
Moringlane
Jean R
JR
Kirsch
Carl-Martin
CM
D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013004:Somatostatin / Q000031:analogs & derivatives*
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C094279:indium-111-octreotide; D013004:Somatostatin; C444119:technetium Tc 99m depreotide; D015282:Octreotide