Rhodium complex-catalyzed Pauson-Khand-type reaction with aldehydes as a CO source.
With aldehydes as a CO source under solvent-free conditions, rhodium complex efficiently catalyzed an intramolecular carbonylative alkene-alkyne coupling (Pauson-Khand-type reaction) and various bicyclic enones were obtained in high yield. Experiments under argon flow and a 13C-labeling experiment suggested that almost no free carbon monoxide was generated in this reaction. When noncationic rhodium complex with chiral phosphine was used as a chiral catalyst, the reaction proceeded enantioselectively to give various chiral cyclopentenones in up to 90% ee under solvent-free conditions.
Shibata
Takanori
T
Department of Chemistry, Faculty of Science, Okayama University, Tsushima, Okayama 700-8530, Japan. tshibata@cc.okayama-u.ac.jp
Toshida
Natsuko
N
Takagi
Kentaro
K