Lipopolysaccharide increases resistin gene expression in vivo and in vitro.
Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis. We speculated that resistin may be involved in inflammatory processes and be induced by inflammatory stimuli. In this study, we tested whether lipopolysaccharide (LPS) induced resistin expression in rats. The results show that resistin mRNA levels in white adipose tissue and white blood cells were increased by LPS treatment. LPS also increased resistin mRNA levels in 3T3-L1 adipocytes and human peripheral blood monocytes. The results suggest that resistin is involved in insulin resistance and probably in other inflammatory responses.
Lu
Shao-Chun
SC
Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, Taipei 100, Taiwan. lsc@ccms.ntu.edu.tw
Shieh
Wei-Yeong
WY
Chen
Chia-Ying
CY
Hsu
Shu-Ching
SC
Chen
Hui-Ling
HL
D016475:3T3 Cells; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005786:Gene Expression Regulation / Q000187:drug effects*; D006729:Hormones, Ectopic / Q000235:genetics*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D020932:Nerve Growth Factor; D011506:Proteins; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D052243:Resistin; D000077154:Rosiglitazone; D013844:Thiazoles / Q000494:pharmacology; D045162:Thiazolidinediones
D017931:DNA Primers; D006729:Hormones, Ectopic; D007004:Hypoglycemic Agents; D036341:Intercellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; D011506:Proteins; C486574:RETNLB protein, human; D012333:RNA, Messenger; D052243:Resistin; C499623:Retn protein, mouse; C499622:Retn protein, rat; C413576:Retnla protein, mouse; C486575:Retnla protein, rat; D013844:Thiazoles; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D020932:Nerve Growth Factor