A novel rotometer based on a RISC microcontroller.
A new, low-cost rotometer, based on a reduced instruction set computer (RISC) microcontroller, is presented. Like earlier devices, it counts the number and direction of full turns for predetermined time periods during the evaluation of turning behavior induced by drug administration in rats. The present stand-alone system includes a nonvolatile memory for long-term data storage and a serial port for data transmission. It also contains a display for monitoring the experiments and has battery backup to avoid interruptions owing to power failures. A high correlation was found (r > .988, p < 2 x 10(-14)) between the counts of the rotometer and those of two trained observers. The system reflects quantitative differences in turning behavior owing to pharmacological manipulations. It provides the most common counting parameters and is inexpensive, flexible, highly reliable, and completely portable (weight including batteries, 159 g).
Heredia-López
F J
FJ
Universidad Autónoma de Yucatán, Av. Itzaes No. 490 x 59, Mérida, Yucatán, C.P. 97000, Mexico.
Bata-García
J L
JL
Alvarez-Cervera
F J
FJ
Góngora-Alfaro
J L
JL
D000818:Animals; D004298:Dopamine / Q000378:metabolism; D008297:Male; D008568:Memory; D008838:Microcomputers; D009068:Movement / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012399:Rotation; D012984:Software; D014159:Transducers
D016627:Oxidopamine; D004298:Dopamine