title: Gene finding strategies.
abstract: Both linkage and association methods have been used to localise and identify genes related to behaviour and other complex traits. The linkage approach (parametric or non-parametric) can be used for whole genome screens to localise genes of unknown function. The parametric linkage approach is very effective for locating single-gene disorders and is usually based on large family pedigrees. The non-parametric method is useful to detect quantitative trait loci (QTLs) for complex traits and was originally developed for sib pair analyses. Genetic association studies are most often used to test the association of alleles at a candidate gene with a disease or with levels of a quantitative trait. Allelic association between a trait and a marker can be studied in a case-control design, but because of possible problems due to population stratification, within-family designs have been proposed as the optimal test for association.
authors.affiliation: Department of Biological Psychology, Free University of Amsterdam, Van der Boechorstraat 1, 1081 BT Amsterdam, The Netherlands. jm.vink@psy.vu.nl
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Vink
authors.forename: D I
authors.initials: DI
authors.lastname: Boomsma
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005828:Genetics, Population; D006801:Humans; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D018709:Statistics, Nonparametric
chemical_list: D005819:Genetic Markers