title: Effects of isulin-like growth factor-I on maternal and fetal plasma amino acid levels in pregnant rats.
abstract: Pregnant rats were subcutaneously administered with recombinant human insulin-like growth factor-I (rhIGF-I) in doses of 0 (control), 1, 2, and 4 microg/g body weight per day from day 18 to 21 of pregnancy. On day 21 of pregnancy, maternal and fetal plasma samples were collected and those amino acid levels were measured. The ratios of fetal/maternal plasma amino acids, especially leucine, isoleucine, tryptophan, phenylalanine and tyrosine, increased in 2 microg rhIGF-I treated group. Both total fetal weight and total placental weight were also higher than those in the control group. These results suggested that IGF-I enhanced fetal growth by, as one of its possible mechanisms, promoting placental amino acid supplies from the mother to fetuses.
authors.affiliation: Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Boonrit
authors.initials: B
authors.lastname: Thongsong
authors.forename: Makoto
authors.initials: M
authors.lastname: Bonkobara
authors.forename: Mitsuhito
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Jong-Sik
authors.initials: JS
authors.lastname: Jang
authors.forename: Naoaki
authors.initials: N
authors.lastname: Matsuki
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Inaba
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ono
mesh_terms: D000596:Amino Acids / Q000097:blood*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000098:blood supply* / Q000187:drug effects*; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
chemical_list: D000596:Amino Acids; D007334:Insulin-Like Growth Factor I