The antimicrobial activity of Aspergillus fumigatus is enhanced by a pool of bacteria.
In a screening program for new antibiotic producers, a strain of Aspergillus fumigatus was isolated from Brazilian soil samples. A pool of autoclaved bacteria was added to part of the fungus culture on the second day of fermentation to increase antibiotic production. The chloroform extract from the culture broth to which the pool of autoclaved bacteria was added showed an increase of 55%, 63% and more than 100% in activity against Staphylococcus aureus, Candida albicans and Micrococcus luteus, respectively. Also, the HPLC chromatographic profiles of the chloroform extracts from both culture conditions were different. Two active compounds were isolated from the broth of the culture grown in the presence of pooled bacteria and were identified as 3,4-dimethoxyphenol and 1,3,5-trimethoxybenzene.
Furtado
Niege Araçari Jacometti Cardoso
NA
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brazil.
Said
Suraia
S
Ito
Izabel Yoko
IY
Bastos
Jairo Kenupp
JK
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D001428:Bacterial Vaccines / Q000008:administration & dosage; D001938:Brazil; D002176:Candida albicans / Q000187:drug effects; D016982:Micrococcus luteus / Q000187:drug effects; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines