The effect of dextran to restore the activity of pulmonary surfactant inhibited by albumin.
Pulmonary surfactant is crucial to maintain the proper functioning of the respiration system. Certain types of blood proteins (e.g. albumin) were found to inhibit the activity of pulmonary surfactant. Axisymmetric Drop Shape Analysis (ADSA) was used to study the effect of dextran to restore the activity of an albumin-inhibited pulmonary surfactant. It was found that dextran could effectively restore surface tension properties of the inhibited surfactant in vitro. Furthermore, dextran improved the performance of pulmonary surfactants when albumin was absent. It was found that when a surfactant film was under high compression (e.g. above 70% surface area reduction), the presence of dextran increased film stability, so that the film could sustain high surface pressures without being collapsing.
Lu
J J
JJ
Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ont., Canada M5S 3G8.
Cheung
W W Y
WW
Yu
L M Y
LM
Policova
Z
Z
Li
D
D
Hair
M L
ML
Neumann
A W
AW
D000418:Albumins / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties / Q000187:drug effects; D013500:Surface Tension / Q000187:drug effects; D013997:Time Factors
D000418:Albumins; D003911:Dextrans; D011663:Pulmonary Surfactants