title: Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia.
abstract: Epidemiological data indicate that acute lymphoblastic leukemia (ALL) could be induced by interactions between the immune system and early childhood infections. Mannose-binding lectin (MBL) plays a critical role in the immune response in early childhood before specific immune protection develops. We investigated whether there may be an association between childhood ALL and low-producing MBL genotypes. Serum MBL levels depend on normal (A) or defective (O) alleles, and on normal (Y) or reduced (X) promoter activities. For this study, 137 noninfants with ALL and 250 controls were classified into 3 MBL genotype groups according to their influence on the serum level of functional MBL: group I, YA/YA and YA/XA (higher levels); group II, XA/XA and YA/O (intermediate levels); and group III, MBL insufficiency with XA/O or O/O (MBL-deficient) genotypes. Compared with controls, cases more often had low-level genotypes (I/II/III: 63 [46%]/44 [32%]/30 [22%] vs 145 [58%]/65 [26%]/40 [16%]; P =.02) and MBL deficiency (8.8% vs 2.8%; P =.009). Thus, the ALL odds ratio for MBL-deficient versus nondeficient individuals was 3.3 (95% CI, 1.3-8.7), whereas the ALL odds ratio for group I versus group II/III genotypes was 0.62 (95% CI, 0.41-0.94). MBL group III patients were significantly younger at diagnosis than patients in group I/II (median, 3.9 vs 5.2 years; P =.04). The study shows that the presence of low-level MBL genotypes is associated with an increased risk of childhood ALL, particularly with early age at onset.
authors.affiliation: Pediatric Clinic II, Juliane Marie Centre, Department of Clinical Immunology, The University Hospital, Rigshospitalet, Copenhagen, Denmark. kschmiegelow@rh.dk
authors.forename: Kjeld
authors.initials: K
authors.lastname: Schmiegelow
authors.forename: Peter
authors.initials: P
authors.lastname: Garred
authors.forename: Birgitte
authors.initials: B
authors.lastname: Lausen
authors.forename: Bente
authors.initials: B
authors.lastname: Andreassen
authors.forename: Bodil Laub
authors.initials: BL
authors.lastname: Petersen
authors.forename: Hans Ole
authors.initials: HO
authors.lastname: Madsen
mesh_terms: D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D037241:Mannose-Binding Lectins / Q000097:blood / Q000172:deficiency / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*
chemical_list: D037241:Mannose-Binding Lectins