BRCA1 in non-inherited breast carcinomas (Review).
Breast cancer occurs in hereditary and sporadic form. Breast cancer susceptibility gene (BRCA1) is known to be responsible for hereditary breast cancer. BRCA1 mutations are rare in sporadic cancers, but loss of BRCA1 resulting from reduced expression or incorrect subcellular localization is postulated to be important in non-familial breast cancers. More than 300 germline mutations have been identified so far in patients with familial breast and/or ovarian cancer, however, only a few somatic mutations have been identified in sporadic breast cancer. The decreased expression of BRCA1 in sporadic breast cancer is thought to be caused by other mechanisms, such as CpG methylation. BRCA1 expression may play an important role in the pathogenesis and prognosis of sporadic breast carcinoma.
Yang
Qifeng
Q
Department of General Surgery, Qilu Hospital, Shandong University, Ji'nan, Shandong Province, P.R. China. yang-qf@mail.wakayama-med.ac.jp
Yoshimura
Goro
G
Nakamura
Misa
M
Nakamura
Yasushi
Y
Suzuma
Takaomi
T
Umemura
Teiji
T
Mori
Ichiro
I
Sakurai
Takeo
T
Kakudo
Kennichi
K
D000368:Aged; D000369:Aged, 80 and over; D019313:BRCA1 Protein / Q000378:metabolism*; D001943:Breast Neoplasms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019175:DNA Methylation; D005260:Female; D005544:Forecasting; D019398:Genes, BRCA1 / Q000502:physiology*; D016147:Genes, Tumor Suppressor; D018095:Germ-Line Mutation; D006801:Humans; D008875:Middle Aged
D019313:BRCA1 Protein