title: BGP expression in gastric biopsies may predict the development of new lesions after local treatment for early gastric cancer.
abstract: BACKGROUND
  Our previous studies have demonstrated the significant role of the generative cells of intestinal metaplasia (IM) expressing brain (fetal)-type glycogen phosphorylase (BGP) (BGP-IM) as a premalignant lesion of intestinal-type adenocarcinoma. The aims of the present study were to investigate the incidence of BGP-IM in gastric biopsy specimens and to establish BGP-IM as a predictor of the coexistence of accessory carcinoma and/or metachronous cancers before and after local treatment for early gastric carcinoma.
  
  
  METHODS
  We studied the incidence of BGP-IM in eight endoscopic biopsy specimens of methylene blue-positive mucosa of the stomach obtained from patients with multiple gastric carcinomas (n = 14), a single carcinoma (n = 25), and atrophic gastritis (n = 20).
  
  
  RESULTS
  BGP positivity was 93.3% in the multiple carcinomas and 80.0% in the single carcinomas. The incidences of BGP-IM (mean percentage +/- SD) in the stomachs with multiple carcinomas, single carcinoma, and atrophic gastritis were 83.2% +/- 22.8%, 36.5% +/- 41.3%, and 7.1% +/- 18.0%, respectively. The incidence was significantly higher in the stomachs with multiple carcinomas than in those with a single carcinoma or those with atrophic gastritis (P < 0.001).
  
  
  CONCLUSIONS
  It is suggested that the frequent appearance of BGP-IM reflects the high potential of carcinogenesis of intestinal-type gastric cancer, and that the involvement of BGP-IM in more than 50% of the eight biopsies may be a predictor of the coexistence of accessory and/or metachronous carcinoma before and after local treatment for early gastric carcinoma.
authors.affiliation: Second Department of Surgery, Kumamoto University School of Medicine, Honjo, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Shimada
authors.forename: Kenji
authors.initials: K
authors.lastname: Shiomori
authors.forename: Ubehiko
authors.initials: U
authors.lastname: Honmyo
authors.forename: Masanobu
authors.initials: M
authors.lastname: Maeno
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yagi
authors.forename: Michio
authors.initials: M
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001706:Biopsy; D002277:Carcinoma / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy*; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005757:Gastritis, Atrophic / Q000453:epidemiology / Q000378:metabolism; D025002:Glycogen Phosphorylase, Brain Form / Q000096:biosynthesis*; D006801:Humans; D015994:Incidence; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011237:Predictive Value of Tests; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy*
chemical_list: D014408:Biomarkers, Tumor; D025002:Glycogen Phosphorylase, Brain Form