Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression.
CD1d-restricted T-cell receptor Valpha-invariant natural killer T (NKT) cells are important regulators of immune responses through their efficient secretion of T helper 1 (Th1) and Th2 cytokines. Recently, it has been shown that this NKT-cell population contains functionally distinct subsets, producing different sets of cytokines and cytotoxic effector molecules. NKT-cell subsets are also distinct from each other in their expression of adhesion molecules and chemokine receptors, suggesting that they might be targeted to different tissues and perform different immune functions.
Kim
Chang H
CH
Laboratory of Immunology and Hematopoiesis, Dept of Veterinary Pathobiology, Biochemistry and Molecular Biology Program, Purdue University, 1243 VPTH, West Lafayette, IN 47907-1243, USA. chkim@purdue.edu
Butcher
Eugene C
EC
Johnston
Brent
B
D016207:Cytokines / Q000096:biosynthesis; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D007694:Killer Cells, Natural / Q000145:classification / Q000276:immunology*; D010641:Phenotype; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D019707:Receptors, Chemokine / Q000378:metabolism; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016207:Cytokines; D016693:Receptors, Antigen, T-Cell, alpha-beta; D019707:Receptors, Chemokine