title: Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats.
abstract: The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.
authors.forename: A A
authors.initials: AA
authors.lastname: Al-Qarawi
authors.forename: H A
authors.initials: HA
authors.lastname: Abdel-Rahman
authors.forename: B H
authors.initials: BH
authors.lastname: Ali
authors.forename: S A
authors.initials: SA
authors.lastname: El Mougy
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000818:Animals; D006035:Glycyrrhiza / Q000633:toxicity*; D006854:Hydrocortisone / Q000097:blood; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects*; D010936:Plant Extracts / Q000633:toxicity*; D011188:Potassium / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood
chemical_list: D010936:Plant Extracts; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin; D011188:Potassium; D006854:Hydrocortisone