The efficacy of papaverine administration by different routes for the treatment of experimental acute cerebral vasospasm.
OBJECTIVE
To compare the effect of papaverine (PPV) by different routes of administration for the treatment of experimental acute cerebral vasospasm.


METHODS
A rabbit model of acute cerebral vasospasm induced by autologous blood injected into the basilar and prepontine cistern was used. The PPV (2mg/kg) was injected either by an intravenous (IV), intra-arterial (IA), intra-cisternal (IC), or combination of intra-arterial and intra-cisternal (IA+IC) routes. Basilar artery diameters were measured before and after vasospasm was induced and after PPV treatment.


RESULTS
Induction of vasospasm reduced basilar artery diameters by more than 50% in all animals. Compared to artery diameters before vasospasm, diameters after PPV treatment via the IV route were only reduced by 0.5+/-4.7%. Other reductions in the diameter included 29.1+/-10.4%, about 1.8+/-3.1%, and about 26.7+/-8.4% in the IA, IC, and IA+IC groups, respectively. However, IA administration of PPV caused obvious side effects.


CONCLUSIONS
Intra-arterial application of the PPV was the most effective way to treat vasospasm in this study. The efficacy of IC route in our study did not confirm the results of prior study. The possibility of side effects of PPV via the IA route should be considered before clinical application.
Liu
Hon-Man
HM
Department of Medical Imaging, Hospital and Medical College, National Taiwan University, Taipei, Taiwan.
Tu
Yong-Kwang
YK
D000208:Acute Disease; D000818:Animals; D002404:Catheterization; D002533:Cerebral Angiography; D002946:Cisterna Magna / Q000502:physiology; D007091:Image Processing, Computer-Assisted; D007267:Injections; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D010208:Papaverine / Q000008:administration & dosage* / Q000627:therapeutic use*; D011817:Rabbits; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000473:pathology
D014665:Vasodilator Agents; D010208:Papaverine