Adult brain neurogenesis and depression.
The waning and waxing of neurogenesis in brain areas such as the dentate gyrus is proposed as a key factor in the descent into and recovery from clinical depression, respectively. A decrease in neurogenesis could occur due to genetic factors, stress (especially because of the involvement of adrenal corticoids), and/or a decline in serotonergic neurotransmission. An increase in neurogenesis could be brought about by several factors, but especially those that activate the serotonin 5-HT(1A) receptor. The possible interaction of immune system factors, especially the proinflammatory cytokines, with adult brain neurogenesis is discussed.
Jacobs
Barry L
BL
Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA. barryj@princeton.edu
D000818:Animals; D001921:Brain / Q000378:metabolism*; D016207:Cytokines / Q000009:adverse effects* / Q000378:metabolism; D018891:Dentate Gyrus / Q000378:metabolism*; D003866:Depressive Disorder / Q000276:immunology* / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008938:Mitosis; D009474:Neurons / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism
D016207:Cytokines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin