title: Frequent seizures with elevated interleukin-6 at the eruptive stage of exanthema subitum.
abstract: A 15-month-old girl developed frequent seizures at the eruptive stage of exanthema subitum. The eruption persisted for 2 weeks. Serum immunoglobulin G antibody to human herpes virus type 6 (HHV-6) increased markedly. Interleukin-6 was elevated whereas HHV-6 deoxyribonucleic acid was not detected in cerebrospinal fluid. These findings suggest that immune-mediated reactions after HHV-6 infection rather than direct action of active HHV-6 are responsible for frequent seizures in this case.
authors.affiliation: Department of Paediatrics, Otsu Red Cross Hospital, Otsu, Japan. masumigo@mbox.kyoto-inet.or.jp
authors.forename: Tohshin
authors.initials: T
authors.lastname: Go
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000208:Acute Disease; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D004569:Electroencephalography; D005077:Exanthema Subitum / Q000097:blood / Q000150:complications* / Q000276:immunology*; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000276:immunology*; D010507:Periodicity; D012640:Seizures / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M; D015850:Interleukin-6