Expression of endogenous heme oxygenase on surface of placental trophoblasts of pregnant women with intrauterine growth retardation of the fetus.
OBJECTIVE
To examine endogenous heme oxygenase (HO) expression on the surface of placental trophoblasts of pregnant women who had a fetus with intrauterine growth retardation (IUGR), so as to explore the pathogenesis of IUGR.


METHODS
Immunohistochemical method were used to detect the expression of HO-1 in idiopathic IUGR patients (IUGR group), patients with pregnancy induced hypertension (PIH) complicated by IUGR (PIH+IUGR group) and normal pregnant women (control group) with specific HO antibody. Quantitative analysis was conducted to determine the quantity of HO.


RESULTS
The staining areas of HO-1 in IUGR group (64.27+/-10.59 micrometer(2)) and PIH+IUGR group (61.54+/-10.59 micrometer(2)) were significantly lower than that of control group (96.56+/-15.23 micrometer(2), P<0.01), but there was no significant differences between the former 2 groups.


CONCLUSIONS
Abnormal reduction in endogenous HO on the surface of placental trophoblasts may be one of the important mechanisms for the onset of IUGR.
Wang
Yi-Peng
YP
Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Yu
Yan-Hong
YH
D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D006801:Humans; D010920:Placenta / Q000166:cytology*; D011247:Pregnancy; D014327:Trophoblasts / Q000201:enzymology* / Q000378:metabolism
D006419:Heme Oxygenase (Decyclizing)