title: A planned randomized clinical trial of treatment for mild gestational diabetes mellitus.
abstract: OBJECTIVE
  A planned study is described which will determine whether a benefit exists for the treatment of mild carbohydrate intolerance during pregnancy.
  
  
  METHODS
  A randomized clinical trial of women with mild gestational diabetes will compare perinatal outcomes in those receiving diet therapy and insulin as required versus those randomized to no specific treatment.
  
  
  RESULTS
  The primary outcome of this study will be a composite of neonatal morbidity in the treatment and control groups.
  
  
  CONCLUSIONS
  A randomized treatment trial of mild gestational diabetes mellitus will clarify whether identification and treatment of mild gestational diabetes mellitus reduces perinatal morbidity. This information will aid in selecting appropriate thresholds for the treatment of gestational diabetes mellitus.
authors.affiliation: The Maternal Fetal Medicine Units Network, The National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Landon
authors.forename: E
authors.initials: E
authors.lastname: Thom
authors.forename: C Y
authors.initials: CY
authors.lastname: Spong
authors.forename: S G
authors.initials: SG
authors.lastname: Gabbe
authors.forename: S
authors.initials: S
authors.lastname: Leindecker
authors.forename: F
authors.initials: F
authors.lastname: Johnson
authors.forename: K
authors.initials: K
authors.lastname: Lain
authors.forename: M
authors.initials: M
authors.lastname: Miodovnik
authors.forename: M
authors.initials: M
authors.lastname: Carpenter
mesh_terms: D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D004035:Diet Therapy / Q000379:methods*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007226:Infant Mortality; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use*; D008403:Mass Screening; D015337:Multicenter Studies as Topic; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D016032:Randomized Controlled Trials as Topic; D014481:United States / Q000453:epidemiology
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin