Propranolol inhibits hyphal development in Candida albicans.
Propranolol was used to investigate the role of phosphatidic acid (PA) and diacylglycerol in the dimorphic transition in Candida albicans. Propranolol was able to inhibit the appearance of germ tubes without decreasing growth rate. Data suggest that inhibition of morphogenesis may be due to binding by propranolol of PA derived from PLD1 hydrolysis of phosphatidylcholine.
Baker
Carol A
CA
Department of Microbiology & Immunology. Department of Stomatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Desrosiers
Kevin
K
Dolan
Joseph W
JW
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development*; D002478:Cells, Cultured; D004075:Diglycerides / Q000494:pharmacology; D006801:Humans; D010712:Phosphatidic Acids / Q000494:pharmacology; D010739:Phospholipase D / Q000037:antagonists & inhibitors; D011433:Propranolol / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D000935:Antifungal Agents; D004075:Diglycerides; D010712:Phosphatidic Acids; D011433:Propranolol; D010739:Phospholipase D; C106801:phospholipase D1