Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide.
Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first evidence that statins in clinically relevant dosages indeed affect cerebral cholesterol metabolism. However, these changes were not associated with altered intrathecal secretion of Alzheimer Abeta.
Fassbender
K
K
Department of Neurology, University of Goettingen, Goettingen, Germany. klaus.fassbender@med.uni-goettingen.de
Stroick
M
M
Bertsch
T
T
Ragoschke
A
A
Kuehl
S
S
Walter
S
S
Walter
J
J
Brechtel
K
K
Muehlhauser
F
F
Von Bergmann
K
K
Lütjohann
D
D
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D000924:Anticholesteremic Agents; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D002784:Cholesterol