Comparison of magnesium sulfate and sodium sulfate for removal of water from pesticide extracts of foods.
Water-miscible solvents, such as acetone and acetonitrile, effectively extract both polar and nonpolar pesticide residues from nonfatty foods. The addition of sodium chloride to the resulting acetonitrile-water or acetone-water extract (salting out) results in the separation of the water from the organic solvent. However, the organic solvent layer (pesticide extract) still contains some residual water, which can adversely affect separation procedures that follow, such as solid-phase extraction and/or gas chromatography. Drying agents, such as sodium sulfate or magnesium sulfate, are used to remove the water from the organic extracts. In the present study, we used nuclear magnetic resonance spectroscopy to study the composition of the phases resulting from salting out and to compare the effectiveness of sodium sulfate and magnesium sulfate as drying agents. The study showed that considerable amounts of water remained in the organic phase after phase separation. Sodium sulfate was a relatively ineffective drying agent, removing little or no residual water from the organic solvent. Magnesium sulfate proved to be a much more effective drying agent.
Schenck
Frank J
FJ
U.S. Food and Drug Administration, Southeastern Regional Laboratory, Atlanta, GA 30309, USA. fschenck@ora.fda.gov
Callery
Patrick
P
Gannett
Peter M
PM
Daft
Jonathan R
JR
Lehotay
Steven J
SJ
D003890:Desiccation; D007887:Fabaceae / Q000737:chemistry; D005504:Food Analysis / Q000379:methods*; D007202:Indicators and Reagents; D008278:Magnesium Sulfate / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010573:Pesticide Residues / Q000032:analysis*; D013431:Sulfates / Q000737:chemistry*; D014867:Water
D007202:Indicators and Reagents; D010573:Pesticide Residues; D013431:Sulfates; D014867:Water; C012036:sodium sulfate; D008278:Magnesium Sulfate