title: The kinetics of the removal of the N-methyltrityl (Mtt) group during the synthesis of branched peptides.
abstract: The purpose of this short communication is to describe the reaction rate for the removal of the N-methyltrityl (Mtt) protecting group that is used in solid-phase peptide synthesis for the production of branched and cyclic peptides. The reaction rate was observed to follow zero-order kinetics, and we suggest the optimal conditions for the removal of the Mtt group in batchwise synthesis.
authors.affiliation: Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: D L
authors.initials: DL
authors.lastname: Elbert
mesh_terms: D007700:Kinetics; D013058:Mass Spectrometry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013053:Spectrophotometry; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
chemical_list: D010455:Peptides; D014320:Triphenylmethyl Compounds