[Analysis of the proteomic changes of the serum of the Smad3 targeted deficient mice].
We have studied the proteomic changes of the serum of the Smad3 targeted deficient mice using 2-DE and PMF approaches. 7 proteins expressed at different level in wild type mice and the Smad3 deficient mice were identified. These results would benefit the research on diagnosis and therapy of osteoarthritis and provided clues to studying the important function of Smad3 mediated TGF-beta signals during the skeletal development.
Hao
Zhen-Ming
ZM
Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Yang
Xiao
X
Ying
Wan-Tao
WT
Wang
Jie
J
Qian
Xiao-Hong
XH
Huang
Cui-Fen
CF
D000818:Animals; D004268:DNA-Binding Proteins / Q000097:blood* / Q000172:deficiency / Q000235:genetics; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D005838:Genotype; D051379:Mice; D018345:Mice, Knockout; D010449:Peptide Mapping; D020543:Proteome / Q000032:analysis*; D051900:Smad3 Protein; D015534:Trans-Activators / Q000097:blood* / Q000172:deficiency / Q000235:genetics
D004268:DNA-Binding Proteins; D020543:Proteome; D051900:Smad3 Protein; C497791:Smad3 protein, mouse; D015534:Trans-Activators