Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains.
Eleven analogues of nifedipine (NP) showed synergistic interactions with ampicillin (Ap) and erythromycin (Er) on Escherichia coli K12LE140/F'lac. The antibacterial effect of Ap was enhanced by most analogues but compound (G9) and (+/-)-verapamil (VP) were antagonistic. Two of the 11 compounds (G7, G8) were synergistic with Er and four were additive. With a sensitive clinical isolate of E. coli Gy-1/Ap(sens)Er(res), compound G1 antagonized the antibacterial effect of Ap and a synergistic effect was found in the combination of Er with G4, G5, G6 or G7. None of the drugs had any effect on a multidrug resistant (MDR) clinical isolate of E. coli Gy-2/Ap(res)Er(res).
Gunics
Györgyi
G
Department of Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Farkas
Sándor
S
Motohashi
Noboru
N
Shah
Anamik
A
Harsukh
Gaveriya
G
Kawase
Masami
M
Molnár
Joseph
J
D000667:Ampicillin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004095:Dihydropyridines / Q000737:chemistry / Q000494:pharmacology*; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D004926:Escherichia coli / Q000145:classification* / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004095:Dihydropyridines; D004917:Erythromycin; D000667:Ampicillin; D009543:Nifedipine