[Angiotensin II receptor and oxidative stress].
Angiotensin II(AngII) activates NADH/NAPDH oxidase activity and stimulates reactive oxygen species(ROS) production, which induces many proinflammatory genes such as vascular cell adhesion molecule-1(VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein-1(MCP-1) mainly via AngII type I receptor(AT1). ROS are important in cardiovascular disease because many of these preinflammatory cytokines play a critical role in the initiation and progression of atherosclerosis. AT1 receptor blockade is important to prevent cardiovascular disease. AngII type 1 receptor blocker(ARB) and/or AngII converting enzyme inhibitor(ACEI) are useful for preventing cardiovascular disease. The role of AngII type II receptor(AT2) for producing ROS and/or cardiovascular damage has been studied.
Usui
Makoto
M
Department of Cardiovascular Medicine, Kyushu University Faculty of Medicine.
Egashira
Kensuke
K
D000818:Animals; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D011945:Receptors, Angiotensin / Q000502:physiology*
D011945:Receptors, Angiotensin