Pathways to primary neurodegenerative disease.
The neurodegenerative diseases are an increasing medical and social burden in developed societies. During the last century, and the early part of this, these diseases were defined and classified as separate clinicopathologic entities. However, during this decade, detailed genetic investigations and the use of molecular pathologic tools have suggested that many of these diseases share common mechanisms of pathogenesis. Here I argue that while these diseases have separate and distinct etiologies, these initiate few pathogenic processes that lead to cell death.
Hardy
J
J
Laboratory of Neurogenetics. National Institute on Aging, Bethesda, MD 20892, USA. hardyj@mail.nih.gov
D000818:Animals; D003937:Diagnosis, Differential; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009420:Nervous System / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000473:pathology; D051843:Synucleins; D016875:tau Proteins / Q000378:metabolism
D009419:Nerve Tissue Proteins; D051843:Synucleins; D016875:tau Proteins