What's the matter with HIV-directed killer T cells?
That HIV-specific cytotoxic T-lymphocytes (CTLs) might be defective in some way has stimulated much controversy and research. We use mathematical models to explore the predictions of two competing CTL-defect theories: "defective memory" and "defective activation". We discuss whether these models are consistent with adoptive-transfer experiments in HIV-infected patients and vaccine trials in simian immunodeficiency virus (SIV)-infected monkeys. Finally, we describe experimental tests that could decide among these two theories and a competitor: CTL exhaustion.
Wick
David
D
Statistical Center for HIV and AIDS Research and Prevention, MW-500, Fred Hutchinson Cancer Research Center, 1124 Columbia St. Seattle, WA, 98104-2092, U.S.A. wick@scharp.org
Self
Steven G
SG
D019264:Adoptive Transfer; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008251:Macaca; D018448:Models, Immunological; D018449:SAIDS Vaccines / Q000008:administration & dosage; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology; D015302:Simian Immunodeficiency Virus
D018449:SAIDS Vaccines