[Relationship between apoptotic activity and radiosensitivity in solid tumors: does apoptosis always bring good clinical results?].
Apoptosis has recently been considered to be a predictor of tumor response or outcome following chemotherapy or radiotherapy. Although apoptosis clearly occurs in the very early stages following such treatments, it is unclear whether its frequency correlates with the likelihood of tumor cure following radiotherapy, especially in solid tumors, where the major mode of cell death is necrosis. This review discuses the relationship between apoptotic activity and radiosensitivity or tumor response from various points of view, including experimental systems and clinical conditions.
Miura
Masahiko
M
Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University.
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53
D016159:Tumor Suppressor Protein p53