Effect of an ionic compared to a non-ionic X-ray contrast agent on platelets and coagulation during diagnostic cardiac catheterisation.
The aim of the present study was to evaluate the effects of ionic (ioxaglate) and non-ionic (iopromide) contrast media on haemostatic parameters ex vivo. In 40 patients undergoing coronary angiography, platelet function (platelet reactivity and serotonin concentration) and coagulation markers [thrombin-antithrombin III complexes, prothrombin fragments (F1+2) and the D-dimers] were measured. The use of an ionic X-ray contrast agent (XCA) (ioxaglate) in diagnostic cardiac catheterisation angiography is associated with lower thrombin generation and lower activation of the platelet system than when a non-ionic XCA is employed (iopromide). The results thus confirm the results of various in vitro studies and animal investigations.
Jung
F
F
Dresdner Institut für Herz- und Kreislaufforschung, Dresden, Germany. dihkf@saarmail.de
Spitzer
S G
SG
Pindur
G
G
D000368:Aged; D000990:Antithrombin III; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D006328:Cardiac Catheterization / Q000009:adverse effects; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging; D004730:Endothelium, Vascular / Q000293:injuries; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007485:Ioxaglic Acid / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D010447:Peptide Hydrolases / Q000097:blood; D015539:Platelet Activation / Q000187:drug effects; D010976:Platelet Count; D011446:Prospective Studies; D011516:Prothrombin; D012701:Serotonin / Q000378:metabolism
D003287:Contrast Media; D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C046193:antithrombin III-protease complex; C036309:fibrin fragment D; C045879:prothrombin fragment 1.2; D012701:Serotonin; D007472:Iohexol; C038192:iopromide; D000990:Antithrombin III; D011516:Prothrombin; D010447:Peptide Hydrolases; D007485:Ioxaglic Acid