title: Fate of Ah-receptor agonists in organic household waste during anaerobic degradation--estimation of levels using EROD induction in organ cultures of chick embryo livers.
abstract: The fate of 7-ethoxyresorufin O-deethylase (EROD)-inducing compounds in source-separated organic household waste subject to anaerobic degradation (i.e. mesophilic/thermophilic anaerobic treatment) was investigated using organ cultures of embryonic chicken livers from fertilised hen eggs. This bioassay reflects the combined effect of all EROD-inducing, possibly dioxin-like compounds in a sample, including chemicals that are seldom or never analysed. All samples tested induced EROD in the bioassay, indicating the presence of dioxin-like compounds. In the anaerobic processes, the amounts of acid-resistant EROD-inducing compounds coming out of the reactors were considerably higher than the incoming amounts, especially for the low-temperature (mesophilic) process. This apparent production of EROD-inducing compounds may be due to de novo synthesis or to an increase in the EROD-inducing potency of the compounds in the material.
authors.affiliation: Man-Technology-Environment Research Centre, Department of Natural Sciences, Orebro University, Sweden. magnus.engwall@nat.oru.se
authors.forename: M
authors.initials: M
authors.lastname: Engwall
authors.forename: A
authors.initials: A
authors.lastname: Schnürer
mesh_terms: D000818:Animals; D001421:Bacteria, Anaerobic / Q000502:physiology; D001673:Biodegradation, Environmental; D001681:Biological Assay / Q000379:methods; D002642:Chick Embryo; D019363:Cytochrome P-450 CYP1A1 / Q000096:biosynthesis* / Q000494:pharmacology; D004147:Dioxins / Q000032:analysis* / Q000494:pharmacology; D004790:Enzyme Induction; D006795:Household Products; D008099:Liver / Q000201:enzymology; D009924:Organ Culture Techniques; D018336:Receptors, Aryl Hydrocarbon / Q000037:antagonists & inhibitors / Q000502:physiology*; D013696:Temperature; D014865:Waste Disposal, Fluid
chemical_list: D004147:Dioxins; D018336:Receptors, Aryl Hydrocarbon; D019363:Cytochrome P-450 CYP1A1