Characterization of measles sequences from Pune, India.
The goal of this study was to conduct the initial genetic characterization wild-type measles viruses currently circulating in India. Reverse transcription-polymerase chain reaction detected measles RNA in 11 of 14 throat swabs collected from sporadic and outbreak-associated cases in the city of Pune, during 1996-1998. Sequence analysis of the H and N genes showed that six sequences were genotype D4, three were genotype D8, and two were genotype A. Continued virologic surveillance in other areas of India as well as neighboring countries will indicate the extent of genetic diversity present among wild-type measles viruses circulating in India.
Wairagkar
Niteen
N
National Institute of Virology, Pune, India.
Rota
Paul A
PA
Liffick
Stephanie
S
Shaikh
Naseem
N
Padbidri
V S
VS
Bellini
William J
WJ
D002648:Child; D002675:Child, Preschool; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008457:Measles / Q000453:epidemiology / Q000821:virology*; D008459:Measles virus / Q000235:genetics*; D017720:Molecular Epidemiology; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000235:genetics; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D017422:Sequence Analysis, DNA; D014758:Viral Core Proteins / Q000235:genetics
D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D012367:RNA, Viral; D014758:Viral Core Proteins