Regulation of lymphoid homeostasis by interleukin-15.
Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis.
Lodolce
James P
JP
Department of Medicine, Ben May Institute for Cancer Research, University of Chicago, 5841 S Maryland Ave MC 6084, Chicago, IL 60637, USA.
Burkett
Patrick R
PR
Koka
Rima M
RM
Boone
David L
DL
Ma
Averil
A
D000818:Animals; D002455:Cell Division; D006801:Humans; D007156:Immunologic Memory; D019409:Interleukin-15 / Q000378:metabolism* / Q000502:physiology*; D008214:Lymphocytes / Q000378:metabolism*; D008954:Models, Biological; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D015398:Signal Transduction
C508024:IL15RA protein, human; C508025:Il15ra protein, mouse; D019409:Interleukin-15; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2