title: Resorbable posterolateral graft containment in a rabbit spinal fusion model.
abstract: The effect of a resorbable graft containment device was evaluated in a rabbit posterolateral lumbar spinal fusion model. Twenty rabbits were divided into four groups: autogenous bone graft (ABG), ABG with the MacroPore containment device (MacroPore Biosurgery Inc, San Diego, Calif) (ABG+MP), demineralized bone matrix (DBM), and DBM with the containment device (DBM+MP). Fusion mass was assessed at 6 weeks with high resolution radiographs and volumetric computed tomography (CT). The graft containment device was associated with alteration of the fusion mass structure and significant enhancement of fusion mass volume (ABG versus ABG+MP, P=.027; DBM versus DBM+MP, P=.043). A bioabsorbable, protective graft containment device successfully enhanced posterolateral spinal fusion mass volume.
authors.affiliation: Department of Metabolic Bone Diseases and Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Poynton
authors.forename: Emre
authors.initials: E
authors.lastname: Tomin
authors.forename: G Bryan
authors.initials: GB
authors.lastname: Cornwall
authors.forename: Fengyu
authors.initials: F
authors.lastname: Zheng
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Lane
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods*; D003131:Combined Modality Therapy; D006084:Graft Rejection; D006085:Graft Survival; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery*; D008422:Materials Testing; D023421:Models, Animal; D011336:Probability; D011474:Prosthesis Design; D012680:Sensitivity and Specificity; D012756:Sheep; D013123:Spinal Fusion / Q000295:instrumentation / Q000379:methods*; D014182:Transplantation, Autologous
chemical_list: D001672:Biocompatible Materials