title: Meta-analysis of techniques for closure of midline abdominal incisions.
abstract: BACKGROUND
  Various randomized studies have evaluated techniques of abdominal fascia closure but controversy remains, leaving surgeons uncertain about the optimal method of preventing incisional hernia.
  
  
  METHODS
  Medline and Embase databases were searched. All trials with a follow-up of at least 1 year that randomized patients with midline laparotomies to closure of the fascia by different suture techniques and/or suture materials were subjected to meta-analysis. Primary outcome was incisional hernia; secondary outcomes were wound dehiscence, wound infection, wound pain and suture sinus formation.
  
  
  RESULTS
  Fifteen studies were identified with a total of 6566 patients. Closure by continuous rapidly absorbable suture was followed by significantly more incisional hernias than closure by continuous slowly absorbable suture (P < 0.009) or non-absorbable suture (P = 0.001). No difference in incisional hernia incidence was found between slowly absorbable and non-absorbable sutures (P = 0.75), but more wound pain (P < 0.005) and more suture sinuses (P = 0.02) occurred after the use of non-absorbable suture. Similar outcomes were observed with continuous and interrupted sutures, but continuous sutures took less time to insert.
  
  
  CONCLUSIONS
  To reduce the incidence of incisional hernia without increasing wound pain or suture sinus frequency, slowly absorbable continuous sutures appear to be the optimal method of fascial closure.
authors.affiliation: Department of General Surgery, Erasmus University Medical Centre Rotterdam - Dijkzigt, Rotterdam, The Netherlands. mvantriet@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: van 't Riet
authors.forename: E W
authors.initials: EW
authors.lastname: Steyerberg
authors.forename: J
authors.initials: J
authors.lastname: Nellensteyn
authors.forename: H J
authors.initials: HJ
authors.lastname: Bonjer
authors.forename: J
authors.initials: J
authors.lastname: Jeekel
mesh_terms: D006555:Hernia, Ventral / Q000517:prevention & control*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D013536:Suture Techniques / Q000592:standards*; D013537:Sutures; D014945:Wound Healing