title: Effect of the correction of metabolic acidosis on nutritional status in elderly patients with chronic renal failure.
abstract: BACKGROUND
  Metabolic acidosis (MA) is a frequent complication in advanced chronic renal failure (CRF). Currently, there is good evidence that MA contributes to malnutrition in CRF patients.
  
  
  METHODS
  We evaluated the effect of correcting MA on nutritional status after 6 months of oral sodium bicarbonate supplementation in 18 patients aged 73 +/- 6 years with CRF to maintain serum bicarbonate levels at 24 +/- 2 mmol/L. The following parameters were measured: dietary record, energy intake, dietary protein intake (DPI), mini-nutritional assessment (MNA), serum albumin level, prealbumin level, prognosis inflammatory and nutritional index (PINI), and protein catabolic rate (nPCR).
  
  
  RESULTS
  No significant changes in body weight or systolic and diastolic blood pressure were observed. Serum albumin and prealbumin levels showed a significant increase. nPCR decreased significantly. DPI, energy intake, PINI, and MNA score did not change significantly. No patient reported side effects or fluid retention during the study.
  
  
  CONCLUSIONS
  Correction of MA improves serum albumin and prealbumin concentration, and it is not associated with any significant change in DPI, but induces a decrease in nPCR values. Whereas nPCR may provide an index of protein catabolism, it does not differentiate between dietary sources of protein or net catabolism of endogenous proteins. In the absence of dietary changes, the decrease in nPCR values may be attributed to a decrease in whole body protein degradation.
authors.affiliation: Department of Nephrology, Dunkerque General Hospital, Dunkerque, France.
authors.forename: Cathy
authors.initials: C
authors.lastname: Verove
authors.forename: Nathalie
authors.initials: N
authors.lastname: Maisonneuve
authors.forename: Abdelghani
authors.initials: A
authors.lastname: El Azouzi
authors.forename: Amal
authors.initials: A
authors.lastname: Boldron
authors.forename: Raymond
authors.initials: R
authors.lastname: Azar
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D000368:Aged; D001639:Bicarbonates / Q000097:blood; D015930:Diet Records; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D015596:Nutrition Assessment; D009748:Nutrition Disorders / Q000209:etiology* / Q000517:prevention & control; D009752:Nutritional Status; D011446:Prospective Studies; D011506:Proteins / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects; D012709:Serum Albumin / Q000378:metabolism; D017693:Sodium Bicarbonate / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D001639:Bicarbonates; D004044:Dietary Proteins; D011506:Proteins; D012709:Serum Albumin; D017693:Sodium Bicarbonate