title: Synthesis and evaluation of 5-HT(2A) and 5-HT(2C) receptor binding affinities of novel pyrimidine derivatives.
abstract: In an effort to find potential anxiolytic and/or antipsychotic agents with selective 5-HT(2C) affinity a series of new pyrimidine derivatives was prepared and the binding affinities for 5-HT(2A) and 5-HT(2C) receptors were determined.
authors.affiliation: Chemical Research Department, EGIS Pharmaceuticals Ltd., PO Box 100, 1475, Budapest, Hungary. chemistry.rd@egis.hu
authors.forename: Dániel
authors.initials: D
authors.lastname: Bózsing
authors.forename: Ildikó
authors.initials: I
authors.lastname: Simonek
authors.forename: Gyula
authors.initials: G
authors.lastname: Simig
authors.forename: Iván
authors.initials: I
authors.lastname: Jakóczi
authors.forename: István
authors.initials: I
authors.lastname: Gacsályi
authors.forename: György
authors.initials: G
authors.lastname: Lévay
authors.forename: Károly
authors.initials: K
authors.lastname: Tihanyi
authors.forename: Eva
authors.initials: E
authors.lastname: Schmidt
mesh_terms: D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D011743:Pyrimidines; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists