title: Gamma knife radiosurgery for growth hormone-secreting pituitary adenomas invading the cavernous sinus.
abstract: The authors assessed whether gamma knife radiosurgery is effective for patients with acromegaly where the pituitary tumors invaded the cavernous sinus. Radiosurgery was performed on 9 patients (average of 20 Gy to the tumor margin), 8 of whom had already undergone transsphenoidal surgery and/or craniotomy with occasional medication of octreotide to reduce tumor size as well as hormonal levels. All tumors have been well controlled so far with follow-up periods ranging from 12 to 69 months (mean: 42). No complications occurred. Forty percent of the patients showed hormonal normalization at 2 years, with the median being 31 months. Similarly, 50% of the patients demonstrated normalization of GH and IGF-I at 36 months. We conclude that gamma knife radiosurgery is a safe and effective tool to treat these tumors invading the cavernous sinus.
authors.affiliation: Gamma Knife Center, Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan. sfuku@med.nmh.or.jp
authors.forename: S
authors.initials: S
authors.lastname: Fukuoka
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Takanashi
authors.forename: A
authors.initials: A
authors.lastname: Hojo
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D000328:Adult; D002426:Cavernous Sinus / Q000473:pathology / Q000601:surgery*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D013006:Growth Hormone