Biological effects of group IIA secreted phosholipase A(2).
Group IIA secreted phospholipase A(2) (sPLA(2)-IIA) is the most abundant element in human tissues of a large family of low molecular weight phospholipases A(2), which shows properties different from those displayed by the cytosolic phospholipase A(2) involved in the release of arachidonic acid. sPLA(2)-IIA behaves as a ligand for a group of receptors inside the C-type multilectin mannose receptor family and also interacts with heparan sulfate proteoglycans such as glypican, the dermatan/chondroitin sulfate-rich decorin, and the chondroitin sulfate-rich versican, thus being able to internalize to specific compartments within the cell and producing biological responses. This review provides a short summary of the biological actions of sPLA(2)-IIA on intracellular signaling pathways.
Fuentes
Lucía
L
Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, Facultad de Medicina, 47005, Valladolid, Spain.
Hernández
Marita
M
Nieto
María Luisa
ML
Sánchez Crespo
Mariano
M
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001254:Astrocytoma / Q000201:enzymology; D001932:Brain Neoplasms / Q000201:enzymology; D002807:Chondroitin / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D010741:Phospholipases A / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding; D015398:Signal Transduction; D013431:Sulfates / Q000378:metabolism; D014407:Tumor Cells, Cultured
D008024:Ligands; D013431:Sulfates; D016718:Arachidonic Acid; D002807:Chondroitin; D010741:Phospholipases A