[Preimplantation genetic diagnosis experience in Paris: evaluation of first births].
OBJECTIVE
To report the birth of the first fourteen infants conceived after preimplantation genetic diagnosis (PGD) in our unit.


METHODS
Fifty-nine couples were enrolled between January 2000 and July 2001. They had a total of 71 oocyte pick-up cycles. The collected oocytes were inseminated by intracytoplasmic sperm injection. The resulting embryos were biopsied on the third day of development and the genetic analysis was performed on the same day. Most of the embryo transfers were carried out on the fourth day.


RESULTS
The 71 oocyte pick-up cycles yielded 872 oocytes of which 731 were suitable for intacytoplasmic sperm injection. Among the 505 embryos obtained, 421 embryos were biopsied and genetic diagnosis was performed for 312 (74%) of these. 127 embryos were transferred during the course of 58 transfer procedures. There were 18 biochemical and 12 ongoing (7 singles, 4 twins and 1 triple) pregnancies. Fourteen infants have been born and 2 are expected.


CONCLUSIONS
PGD has gained a place among the choices offered to couples at risk of transmission of a serious and incurable genetic disease.
Achour-Frydman
N
N
Service d'Histologie-Embryologie-Cytogénétique à orientation Biologique et Génétique de la Reproduction, Hôpital Antoine-Béclère, 157, rue de la Porte-de-Trivaux, 92141 Clamart, France.
Romana
S
S
Ray
P
P
Hamamah
S
S
Tachdjian
G
G
Munnich
A
A
Vekemans
M
M
Frydman
R
R
D000328:Adult; D001706:Biopsy; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000175:diagnosis / Q000235:genetics; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000235:genetics; D036861:Delivery, Obstetric / Q000379:methods / Q000706:statistics & numerical data; D004624:Embryo Transfer / Q000592:standards; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male; D010062:Ovulation Induction / Q000379:methods / Q000592:standards; D010297:Paris / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D019836:Preimplantation Diagnosis / Q000379:methods* / Q000592:standards; D015397:Program Evaluation; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods* / Q000592:standards