Correlation of proliferating cell nuclear antigen expression with the clinical and biological characteristics and prognosis of hypopharyngeal carcinoma.
OBJECTIVE
To study the association of proliferating cell nuclear antigen (PCNA) with the biological characteristics and clinical behavior of hypopharyngeal carcinoma and with the prognosis of the malignancy.


METHODS
SP-immunohistochemical method was used to detect the expression of PCNA in 48 cancer tissue specimens and 15 specimens of the adjacent tissue of primary hypopharyngeal carcinomas. The number of PCNA-positive cells was represented by proliferating index (PI) of the antigen.


RESULTS
PCNA expression was correlated with the clinical stage, histological grade and clinical recurrence of hypopharyngeal carcinoma as well as the prognosis of the patients, but was not significantly related with the tumor location or the presence of metastasis to the cervical lymph nodes.


CONCLUSIONS
PCNA protein expression may help evaluate the malignancy of hypopharyngeal carcinoma and make prognostic judgement of the patients.
Yao
Lian-Sheng
LS
Department of Otorhinolaryngology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Li
Xiang-Ping
XP
Li
Qi
Q
Zhang
Jin-Hua
JH
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D016019:Survival Analysis
D018809:Proliferating Cell Nuclear Antigen