title: Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba.
abstract: Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC(50) = 23.4 +/- 1.5 microM). Compounds 2 and 4 showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.42 and 32.3 +/- 2.62 micro, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
authors.affiliation: Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea.
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Ko
authors.forename: Jung-Yang
authors.initials: JY
authors.lastname: Jun
authors.forename: Myung-Hoon
authors.initials: MH
authors.lastname: Oh
authors.forename: Sung-Uk
authors.initials: SU
authors.lastname: Park
authors.forename: Ki-Hong
authors.initials: KH
authors.lastname: Kang
authors.forename: Ho-Sub
authors.initials: HS
authors.lastname: Lee
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
mesh_terms: D001713:Biphenyl Compounds; D002460:Cell Line / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D031625:Morus; D008517:Phytotherapy; D010851:Picrates; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D018514:Plant Structures; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001713:Biphenyl Compounds; D003374:Coumarins; D005419:Flavonoids; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D013267:Stilbenes; C030123:coumarin; C004931:1,1-diphenyl-2-picrylhydrazyl