title: [Biophysical and medical and biological aspects of use of polyene antibiotics in combination with dimethylsulfoxide].
abstract: Modern conceptions of the physicochemical properties of dimethylsulfoxide and polyene antibiotics are reviewed. The results of investigations of independent and mutual effects of polyene antibiotics and dimethylsulfoxide on membrane permeability were analysed. The own experimental data of radioprotective and antitumour action of complex dimethylsulfoxide-polyene antibiotics are presented, and the perspectives of their use in medicine are described.
authors.affiliation: Radiation Research Department, National Academy of Sciences of Azerbaidzhan, Baku, Azerbaidzhan.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Ibragimova
authors.forename: D I
authors.initials: DI
authors.lastname: Aliev
authors.forename: I N
authors.initials: IN
authors.lastname: Alieva
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002463:Cell Membrane Permeability / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D018942:Macrolides; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology; D012997:Solvents
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D018942:Macrolides; D011837:Radiation-Protective Agents; D012997:Solvents; D004121:Dimethyl Sulfoxide