title: Abnormal brain energy metabolism shown by in vivo phosphorus magnetic resonance spectroscopy in patients with chronic liver disease.
abstract: We used phosphorus magnetic resonance spectroscopy (31P-MRS) to assess in vivo the brain bioenergetics of 28 patients with liver cirrhosis. Seven had clinical hepatic encephalopathy (HE), nine hepatocellular carcinoma. 31P-MRS was performed by the DRESS localisation technique on occipital lobes. Brain phosphocreatine was significantly reduced in patients with or without overt HE, and inorganic phosphate was increased in both groups of patients. The cytosolic phosphorylation potential (PP), the relative rate of oxidative metabolism and the regulatory [ADP] were all abnormal. Brain PP was inversely correlated with serum ammonia concentration only in patients without liver cancer. The degree of bioenergetic failure was significantly higher in the presence of overt encephalopathy. We conclude that patients with liver cirrhosis had a derangement of brain energy metabolism, and that 31P-MRS offers a non-invasive method for investigating the underlying mechanisms of HE, with relevant implications in the identification and management of this condition.
authors.affiliation: Dipartimento di Medicina Clinica e Biotecnologia Applicata D Campanacci, Bologna, Italy. barbirol@med.unibo.it
authors.forename: B
authors.initials: B
authors.lastname: Barbiroli
authors.forename: S
authors.initials: S
authors.lastname: Gaiani
authors.forename: R
authors.initials: R
authors.lastname: Lodi
authors.forename: S
authors.initials: S
authors.lastname: Iotti
authors.forename: C
authors.initials: C
authors.lastname: Tonon
authors.forename: V
authors.initials: V
authors.lastname: Clementi
authors.forename: G
authors.initials: G
authors.lastname: Donati
authors.forename: L
authors.initials: L
authors.lastname: Bolondi
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D019069:Cell Respiration / Q000502:physiology; D002908:Chronic Disease; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism* / Q000503:physiopathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D010761:Phosphorus Radioisotopes
chemical_list: D010761:Phosphorus Radioisotopes; D000244:Adenosine Diphosphate