title: Egb 761 in the postgenomic era: new tools from molecular biology for the study of complex products such as Ginkgo biloba extract.
abstract: The decoding of the human genome has completely changed our views on medicine. Beyond sequencing, tools of the postgenomic era may lead to a better understanding of various therapies, especially those with a complex effect on numerous cellular components and functions. The development of high-density oligonucleotide microarrays led to pioneer studies on the multiple gene expression effects exhibited by Ginkgo biloba extract EGb 761, changing traditional pharmacology and medicine concepts. Instead of studying a simple gene or protein, a global investigation of all genes or proteins at once can give insights of the complexity of biological systems.
authors.affiliation: Beaufour Ipsen, Paris, France. yves.christen@beaufour-ipsen.com
authors.forename: Yves
authors.initials: Y
authors.lastname: Christen
authors.forename: Estibaliz
authors.initials: E
authors.lastname: Olano-Martin
authors.forename: Lester
authors.initials: L
authors.lastname: Packer
mesh_terms: D005786:Gene Expression Regulation / Q000187:drug effects; D020441:Ginkgo biloba; D020411:Oligonucleotide Array Sequence Analysis; D010936:Plant Extracts / Q000032:analysis* / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology; D000096983:Ginkgo Extract
chemical_list: D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract