title: [Studies on the gonadal function in patients with anorexia nervosa using a highly sensitive radioimmunoassay kit for estradiol].
abstract: We measured serum estradiol (E2) using a highly sensitive radioimmunoassay kit in patients with anorexia nervosa (AN). It is possible to determine the ovarian function with hypogonadism in patients with AN whose levels of E2 were below 10 pg/ml. In patients with extremely low levels of BMI (less than 15 kg/m2), basal levels of E2, LH, FSH and IGF-I increased significantly with gain of body weight. Recovery of the hypothalamic-pituitary-ovarian function in AN patients were correlated with weight gain and nutritional status. The levels of IGF-I and E2 raised in advance of gonadotropins. Using highly sensitive assay of E2, we recognized the clinical usefulness for evaluation of the ovarian function in patients with AN in the course of treatment.
authors.affiliation: Central Clinical Laboratories, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Jibiki
authors.forename: Mari
authors.initials: M
authors.lastname: Hotta
authors.forename: Rie
authors.initials: R
authors.lastname: Okaji
authors.forename: Emi
authors.initials: E
authors.lastname: Odagiri
authors.forename: Kazue
authors.initials: K
authors.lastname: Takano
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis; D010053:Ovary / Q000503:physiopathology*; D011863:Radioimmunoassay
chemical_list: D004958:Estradiol