title: Developmental changes in lysosome morphology and function Leishmania parasites.
abstract: The endocytic pathway of Leishmania parasites has recently come under intense research focus through the development of several markers for various compartments of this pathway. Through these studies a novel multivesicular tubule lysosome has been discovered in promastigote-stage parasites. This organelle has a highly dynamic role during parasite growth and differentiation. This review discusses recent insights into the Leishmania lysosome with respect to its organisation within the endocytic pathway, stage-specific functions, and biogenesis.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic 3010, Australia.
authors.forename: Ross F
authors.initials: RF
authors.lastname: Waller
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: McConville
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D004705:Endocytosis; D007891:Leishmania / Q000166:cytology* / Q000254:growth & development* / Q000276:immunology / Q000648:ultrastructure; D008247:Lysosomes / Q000276:immunology / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D015800:Protozoan Proteins / Q000378:metabolism
chemical_list: D015800:Protozoan Proteins