title: Experimental validation of Monte Carlo depth-dose calculations using radiochromic dye film dosimetry for a beta-gamma 153Sm radionuclide applied to the treatment of rheumatoid arthritis.
abstract: In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distribution shows a very good agreement (within 5%) in the region where the dose deposition is dominated by the beta particle component (first 800 microm depth on tissue-equivalent material). The agreement worsens, reaching a maximum deviation of 15%, at depths close to the maximum range of the beta particles. Finally the agreement improves for the region where the gamma component accounts for one-third of the total absorbed dose (depths >1 mm). The possible contributions to these differences are discussed, as well as their relevance for the application of 153Sm in the treatment of rheumatoid arthritis.
authors.affiliation: Instituto Nacional de Investigaciones Nucleares, Salazar, Estado de México, Mexico. villarre@radone17.ucsf.edu
authors.forename: J E
authors.initials: JE
authors.lastname: Villareal-Barajas
authors.forename: G
authors.initials: G
authors.lastname: Ferro-Flores
authors.forename: O
authors.initials: O
authors.lastname: Hernandez-Oviedo
mesh_terms: D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D001610:Beta Particles; D004396:Coloring Agents; D005720:Gamma Rays; D006801:Humans; D009010:Monte Carlo Method; D011868:Radioisotopes / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D015203:Reproducibility of Results; D012493:Samarium / Q000627:therapeutic use*
chemical_list: D004396:Coloring Agents; D011868:Radioisotopes; D012493:Samarium