title: Expression of endogenous heme oxygenase on surface of placental trophoblasts of pregnant women with intrauterine growth retardation of the fetus.
abstract: OBJECTIVE
  To examine endogenous heme oxygenase (HO) expression on the surface of placental trophoblasts of pregnant women who had a fetus with intrauterine growth retardation (IUGR), so as to explore the pathogenesis of IUGR.
  
  
  METHODS
  Immunohistochemical method were used to detect the expression of HO-1 in idiopathic IUGR patients (IUGR group), patients with pregnancy induced hypertension (PIH) complicated by IUGR (PIH+IUGR group) and normal pregnant women (control group) with specific HO antibody. Quantitative analysis was conducted to determine the quantity of HO.
  
  
  RESULTS
  The staining areas of HO-1 in IUGR group (64.27+/-10.59 micrometer(2)) and PIH+IUGR group (61.54+/-10.59 micrometer(2)) were significantly lower than that of control group (96.56+/-15.23 micrometer(2), P<0.01), but there was no significant differences between the former 2 groups.
  
  
  CONCLUSIONS
  Abnormal reduction in endogenous HO on the surface of placental trophoblasts may be one of the important mechanisms for the onset of IUGR.
authors.affiliation: Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Yi-Peng
authors.initials: YP
authors.lastname: Wang
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Yu
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D006801:Humans; D010920:Placenta / Q000166:cytology*; D011247:Pregnancy; D014327:Trophoblasts / Q000201:enzymology* / Q000378:metabolism
chemical_list: D006419:Heme Oxygenase (Decyclizing)