Alkynylzirconation of alkynes and application to one-pot bisalkynylation of alkynes.
Stereocontrolled alkynylzirconation of unactivated alkynes was achieved by the reaction of an alkyne with Cp2ZrEt2 and alkynyl halide in this order. After hydrolysis of the alkynylzirconation product, trisubstituted enyne derivatives were obtained in good yields. Functionalized enynes were also prepared by the reaction of the alkynylzirconation products with a variety of electrophiles. Subsequent addition of the second alkynyl halide to the alkynylzirconation products provided an in situ protocol for bisalkynylation of alkynes into (Z)-enediynes in good yields.
Liu
Yuanhong
Y
Catalysis Research Center and Graduate School of Pharmaceutical Sciences, Hokkaido University and CREST, Science and Technology Corporation (JST), Sapporo 060-0811, Japan.
Zhong
Zhenqi
Z
Nakajima
Kiyohiko
K
Takahashi
Tamotsu
T