title: Time-domain reconstruction for thermoacoustic tomography in a spherical geometry.
abstract: Reconstruction-based microwave-induced thermoacoustic tomography in a spherical configuration is presented. Thermoacoustic waves from biological tissue samples excited by microwave pulses are measured by a wide-band unfocused ultrasonic transducer, which is set on a spherical surface enclosing the sample. Sufficient data are acquired from different directions to reconstruct the microwave absorption distribution. An exact reconstruction solution is derived and approximated to a modified backprojection algorithm. Experiments demonstrate that the reconstructed images agree well with the original samples. The spatial resolution of the system reaches 0.5 mm.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station 77843-3120, USA.
authors.forename: Minghua
authors.initials: M
authors.lastname: Xu
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000465:Algorithms; D000818:Animals; D007089:Image Enhancement / Q000379:methods*; D066298:In Vitro Techniques; D008872:Microwaves; D018482:Muscle, Skeletal / Q000033:anatomy & histology; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013552:Swine; D013696:Temperature; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*