title: Regulation of life and death by the zinc finger transcription factor Egr-1.
abstract: The biosynthesis of the zinc finger transcription factor Egr-1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors, and cytotoxic metabolites. The 5'-flanking region of the Egr-1 gene contains genetic elements that are essential in connecting stimulation of the cells with enhanced transcription of the Egr-1 gene, and subsequently, transcription of Egr-1-responsive genes. Thus, Egr-1 links cellular signaling cascades with changes in the gene expression pattern. Many biological functions have been attributed to Egr-1. Here, we discuss evidence for Egr-1 control of cellular proliferation and programmed cell death.
authors.affiliation: Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Homburg, Germany. bcgthi@uniklinik-saarland.de
authors.forename: Gerald
authors.initials: G
authors.lastname: Thiel
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cibelli
mesh_terms: D017209:Apoptosis; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors