title: Breast cancer lymphedema: pathophysiology and risk reduction guidelines.
abstract: OBJECTIVE
  To review the normal physiology of the blood capillary-interstitial-lymphatic vessel interface, describe the pathophysiology of lymphedema secondary to treatment for breast cancer, and summarize the physiologic bases of the current National Lymphedema Network (NLN) risk reduction guidelines.
  
  
  METHODS
  Journal articles, anatomy and physiology textbooks, published research data, and Web sites.
  
  
  RESULTS
  Lymphedema occurring after treatment for breast cancer significantly affects physical, psychological, and sexual functioning. About 28% of breast cancer survivors develop lymphedema. When arterial capillary filtration exceeds lymphatic transport capacity, lymphedema occurs. NLN risk reduction guidelines may decrease lymphedema risk.
  
  
  CONCLUSIONS
  Lymphedema is chronic and disfiguring. Most NLN risk reduction guidelines, although not evidence-based, are based on sound physiologic principles. Evidence-based research of the effectiveness of NLN risk reduction guidelines is indicated.
  
  
  CONCLUSIONS
  Until evidence-based research contradicts NLN's risk reduction guidelines, nurses should inform patients with breast cancer about their risk for lymphedema, guidelines to reduce that risk, and the physiologic rationale for the guidelines.
authors.affiliation: School of Nursing,Vanderbilt University, Nashville, TN, USA. Sheila.Ridner@vanderbilt.edu
authors.forename: Sheila H
authors.initials: SH
authors.lastname: Ridner
mesh_terms: D000328:Adult; D000368:Aged; D001132:Arm; D001365:Axilla; D001943:Breast Neoplasms / Q000451:nursing* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002196:Capillaries / Q000502:physiology / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects; D008198:Lymph Nodes / Q000528:radiation effects; D008208:Lymphatic System / Q000502:physiology / Q000503:physiopathology; D008209:Lymphedema / Q000209:etiology / Q000451:nursing* / Q000503:physiopathology*; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012307:Risk Factors