Early myelodysplastic syndrome after allogeneic bone marrow transplantation for acute myeloid leukemia.
A 19-year-old male with de novo acute myeloid leukemia (AML) in complete remission received a bone marrow transplant from a HLA-matched donor. Because of major incompatibility for ABO blood type, bone marrow mononuclear cells of the donor were infused after conditioning including total body irradiation (TBI). Engraftment was confirmed on day +23. On day +91, recipient ABO blood genotype was detected in burst forming-unit erythroid (BFU-E) using polymerase chain reaction. Thereafter, myelodysplastic syndrome (MDS) of recipient origin rapidly developed and progressed into a chronic myelomonocytic leukemia-like disorder. An association between MDS and TBI is suggested.
Muroi
Kazuo
K
Division of Cell Transplantation and Transfusion, Jichi Medical School, Minamikawachi, Tochigi, Japan. muroi-kz@jichi.ac.jp
Kawano
Chizuru
C
Yokote
Taiji
T
Otsuki
Tetsuya
T
Kirito
Keita
K
Komatsu
Norio
N
Ozawa
Keiya
K
D000208:Acute Disease; D000328:Adult; D001787:Blood Group Incompatibility; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology* / Q000628:therapy; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D016609:Neoplasms, Second Primary / Q000209:etiology*; D018183:Transplantation Chimera; D014184:Transplantation, Homologous / Q000009:adverse effects; D014916:Whole-Body Irradiation / Q000009:adverse effects