title: Stable chromosome aberrations in the lymphocytes of a population living in the vicinity of the Semipalatinsk nuclear test site.
abstract: SalomaTranslocation analysis using FISH (fluorescence in situ hybridization) chromosome painting was performed to evaluate the magnitude of exposure to ionizing radiation among the human population living close to the Semipalatinsk nuclear test site in Kazakhstan. We studied two generations of people living in villages that were in the path of the radioactive cloud from the first Soviet surface nuclear test performed in August 1949 and from later tests. The older generation (P(0)) lived in the area at the time of testing, and the younger generation (F(1)) was exposed to smaller doses from the residual fallout and later tests. In both P(0) and F(1) generations, similar translocation frequencies were observed in persons living in either the Semipalatinsk area or a noncontaminated area. Assuming translocation stability in peripheral blood lymphocytes over several decades, these findings suggest that on average, the magnitude of exposure of this cohort in the Semipalatinsk area has been considerably smaller than that reported in the literature. Previously reported doses of the order of 1-4.5 Gy (mean 2.9 Gy in the P(0) generation) cannot be confirmed by the present data.
authors.affiliation: STUK-Radiation and Nuclear Safety Authority, 00881 Helsinki, Finland.
authors.forename: Sisko
authors.initials: S
authors.lastname: Salomaa
authors.forename: Carita
authors.initials: C
authors.lastname: Lindholm
authors.forename: Maira K
authors.initials: MK
authors.lastname: Tankimanova
authors.forename: Zaure Zh
authors.initials: ZZh
authors.lastname: Mamyrbaeva
authors.forename: Armi
authors.initials: A
authors.lastname: Koivistoinen
authors.forename: Maj
authors.initials: M
authors.lastname: Hultén
authors.forename: Riitta
authors.initials: R
authors.lastname: Mustonen
authors.forename: Yuri E
authors.initials: YE
authors.lastname: Dubrova
authors.forename: Rakhmetkaji I
authors.initials: RI
authors.lastname: Bersimbaev
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002869:Chromosome Aberrations / Q000528:radiation effects*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007623:Kazakhstan / Q000453:epidemiology; D008214:Lymphocytes / Q000378:metabolism* / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011847:Radioactive Fallout / Q000009:adverse effects*; D012044:Regression Analysis; D012727:Sex Characteristics; D012907:Smoking
chemical_list: D011847:Radioactive Fallout