BCR-ABL insufficiency for the transformation of human stem cells into CML.
On the basis of numerical and kinetic data, the paper argues against the tenet that BCR-Abl is sufficient for transforming into Chronic Myelogenous leukemia a human hemopoietic stem cell, regardless of degree of pluripotency.
Matioli
G T
GT
USC Medical School, Los Angeles, California 90033, USA.
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000502:physiology*; D006098:Granulocytes / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000473:pathology*; D012016:Reference Values
D016044:Fusion Proteins, bcr-abl