[Contribution of angiotensin II type I and type II receptors(AT-1 and AT-2) to collagen synthesis by skin fibroblasts].
The renin-angiotensin system(RAS) is initially reported to play a crucial role in vasoconstrictive events including hypertension, myocardial infarction, and heart failure. Also, this peptide promotes cardiac myocyte hypertrophy and cardiac fibroblast interstitial fibrotic changes associated with left ventricular hypertrophy. In addition, RAS mediates renal fibrosis by stimulating renal interstitial fibroblasts. These observations suggest that angiotensin II signal plays a critical role in tissue fibrosis of internal organs. This review discusses the molecular biology of angiotensin II receptors that have been implicated in tissue fibrosis induced by skin fibroblasts.
Kawaguchi
Yasushi
Y
Institute of Rheumatology, Tokyo Women's Medical University.
Kamatani
Naoyuki
N
D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism*; D005355:Fibrosis / Q000378:metabolism; D006801:Humans; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000502:physiology*
D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D003094:Collagen