title: Management of hyperthermia in traumatic brain injury.
abstract: Recently there has been much interest in the use of hypothermia in the management of the brain-injured patient and its effect on outcome. Most of these studies examine the use of hypothermia compared with normothermia of 37 degrees C and have failed to demonstrate a benefit in the treatment groups, but what is normothermia in the brain-injured patient? Good epidemiologic evidence suggests that the vast majority of patients admitted to an ICU environment will develop a fever. The development of fever is clearly associated with a worse prognosis. There is now a better understanding of the possible mechanism of harm of fever and the side effects of cooling. Several treatment options for controlling temperature are discussed. Despite a sound physiologic argument for controlling fever in the brain-injured patient, there is no evidence that doing so will improve outcome.
authors.affiliation: Specialist Registrar in Intensive Care Medicine and Reader in Anesthetics, Intensive Care, and Pain Medicine, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, UK.
authors.forename: Chris J S
authors.initials: CJ
authors.lastname: Cairns
authors.forename: Peter J D
authors.initials: PJ
authors.lastname: Andrews
mesh_terms: D001831:Body Temperature; D001930:Brain Injuries / Q000503:physiopathology* / Q000628:therapy; D005334:Fever / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods; D011379:Prognosis; D016896:Treatment Outcome