Warm-antibody autoimmune hemolytic anemia developing after thrombotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura (TTP) and warm-antibody autoimmune hemolytic anemia (AIHA) are uncommon diseases. Although TTP has been increasingly described in association with autoimmune antibodies, there are very few reports of the association with autoimmune hematological conditions, including idiopathic thrombocytopenic purpura and AIHA. Here we describe a patient with classic manifestations of TTP, who was successfully treated with plasma exchange. A few weeks later, she developed warm-antibody AIHA, which responded promptly to prednisone.
Morgensztern
Daniel
D
Division of Hematology-Oncology, University of Miami, Sylvester Cancer Center, VA Medical Center, Fla 33136, USA.
Kharfan-Dabaja
Mohamed A
MA
Tsai
Han-Mou
HM
Lian
Eric C-Y
EC
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D010951:Plasma Exchange; D011241:Prednisone / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000628:therapy
D005938:Glucocorticoids; D011241:Prednisone