title: Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m.
abstract: To investigate the effect of acclimatization to hypoxia on substrate utilization, eight sea level residents were studied during exercise at the same relative (rel) and absolute (abs) work rate as at sea level (SL), under acute (AH), and after 4 weeks exposure to 4100 m altitude (CH). Carbohydrate (CHO) and fat oxidation during exercise at SL were 2.0 +/- 0.2 and 0.3 +/- 0.0 g min(-1), respectively. At AHabs and CHabs CHO oxidation increased (P < 0.05) to 2.5 +/- 0.2 and 2.3 +/- 0.1 for CHO, and fat oxidation decreased (P < 0.05) to 0.2 +/- 0.01 and 0.2 +/- 0.01 g min(-1), respectively. Exercise in AHrel and CHrel did not cause a change in the relative CHO and fat oxidation compared with SL, the absolute rate of CHO oxidized being 1.7 +/- 0.1 and 1.7 +/- 0.02 g min(-1), respectively, and fat oxidation was 0.2 +/- 0.02 g min(-1) in ACrel and 0.3 +/- 0.02 g min(-1) in CHrel. In conclusion, substrate utilization is unaffected by AH and CH, when the work rate is matched to the same relative intensity as at SL.
authors.affiliation: The Copenhagen Muscle Research Centre, Copenhagen Ø, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Lundby
authors.forename: G
authors.initials: G
authors.lastname: Van Hall
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000328:Adult; D000531:Altitude; D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism; D002395:Catecholamines / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005223:Fats / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005260:Female; D005990:Glycerol / Q000032:analysis; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012129:Respiratory Function Tests
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D005223:Fats; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D005990:Glycerol