Synthesis of novel iodinated derivatives of nonoxynol-9 and their bioavailability in rats.
The absorption and distribution of iodinated derivatives of nonoxynol-9, after vaginal administration in rats, were compared with results reported for [14C] nonoxynol-9. Mono-iodinated nonoxynol-9 was synthesized in addition to the radiolabeled derivative incorporating iodide-125 ([125I]). Six hours after dosing, test rats were euthanized and selected tissues were excised and assessed for radioactivity. Levels of radioactive markers in the reproductive system were substantial for both [14C] and [125I]. It was concluded that [125I] mono-iodinated nonoxynol-9 and [14C] nonoxynol-9 possessed similar bioavailability.
Fowler
Philip T
PT
College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA.
Matsumoto
Kazuya
K
Page
Richard C
RC
Digenis
George A
GA
D000282:Administration, Intravaginal; D000818:Animals; D001682:Biological Availability; D002250:Carbon Radioisotopes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D007553:Isotope Labeling; D017137:Nonoxynol / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D017137:Nonoxynol