Ischemic preconditioning of myocardium.
Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel, and expression of many protective proteins. The purpose of this review is to assess the current position in this field and to facilitate future research.
Tyagi
Priya
P
Department of Pharmacology, Maulana Azad Medical College, New Delehi 110002, India. priyatyagi@hotmail.com
Tayal
Girish
G
D000241:Adenosine / Q000378:metabolism; D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D011493:Protein Kinase C / Q000378:metabolism; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism
D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D011493:Protein Kinase C; D010738:Type C Phospholipases; D000241:Adenosine; D001920:Bradykinin