title: Topical 5-ALA photodynamic therapy for the treatment of cutaneous T-cell lymphoma.
abstract: Therapeutic options for cutaneous T cell lymphoma (CTCL) include topical steroids, topical chemotherapy and phototherapy. Patients with limited disease that is unresponsive to these therapies present a particular challenge. We report successful treatment of a patient with two plaques of CTCL using topical photodynamic therapy (PDT). 5-aminolaevulinic acid (5-ALA) was applied 6-24 h preillumination with 100 J/cm2 red light. Treatment was repeated on four occasions with clinical and histological clearance. ALA-PDT may be a useful addition to the therapeutic options for CTCL. Further studies are required to define optimal treatment protocols.
authors.affiliation: University Department of Dermatology, Western Infirmary, Glasgow, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Leman
authors.forename: D C
authors.initials: DC
authors.lastname: Dick
authors.forename: C A
authors.initials: CA
authors.lastname: Morton
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy*; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid