title: Nonisothermal stability tests of famotidine and nizatidine.
abstract: Nonisothermal stability tests have been proposed as an attractive and alternative method to the conventional isothermal stability tests. The stability and the degradation properties of famotidine and nizatidine were investigated using both isothermal and nonisothermal stability test techniques. Linear and logarithmic temperature programs were used and the degradation rate constant and activation energies were calculated using a computer program, which was written in BASIC. Also the advantages and disadvantages of these temperature programs are compared. The method to estimate parameters is based on nonlinear curve fitting the nonisothermal concentration-time-temperature curve equation. The nonisothermal stability test results were compared with the results of isothermal stability tests and similar results were obtained.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
authors.forename: Zelihagül
authors.initials: Z
authors.lastname: Değim
authors.forename: Ilbeyi
authors.initials: I
authors.lastname: Ağabeyoğlu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004867:Equipment Design; D015738:Famotidine / Q000737:chemistry*; D006635:Histamine H2 Antagonists / Q000737:chemistry; D006358:Hot Temperature; D007700:Kinetics; D008722:Methods; D008956:Models, Chemical; D016567:Nizatidine / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D006635:Histamine H2 Antagonists; D015738:Famotidine; D016567:Nizatidine