Monoamine transporter pharmacology and mutant mice.
Monoamine transporters, such as the dopamine transporter, 5-HT transporter and noradrenaline transporter, in the plasma membrane provide effective control over the intensity of monoamine-mediated signaling by recapturing neurotransmitters released by presynaptic neurons. These proteins represent established targets for several psychotropic drugs, including psychostimulants and antidepressants; however, important issues regarding the selectivity and mechanisms of action of these drugs remain unresolved. Although monoamine transporter knockout mice have profound changes in neurotransmission, they provide useful in vivo models to analyze the effects of psychotropic drugs. In this review, we summarize recent insights into the pharmacology of psychotropic drugs using mice in which the genes encoding these transporters have been deleted.
Gainetdinov
Raul R
RR
Howard Hughes Medical Institute Laboratories, Dept of Cell Biology, Box 3287, Duke University Medical Center, Durham, NC 27710, USA. r.gainetdinov@cellbio.duke.edu
Sotnikova
Tatyana D
TD
Caron
Marc G
MG
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D002352:Carrier Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics*; D011619:Psychotropic Drugs / Q000494:pharmacology
D015306:Biogenic Monoamines; D002352:Carrier Proteins; D011619:Psychotropic Drugs