[Analysis of efficacy of complex treatment of patients with differentiated forms of the thyroid gland cancer using distant radiation therapy].
Retrospective analysis of efficacy of complex treatment, including surgical intervention, radioiodine therapy (RITH), suppressive hormonotherapy of differentiated forms of the thyroid gland cancer (DFTHGC) was done in 281 patients with positive effect of postoperative distant radiation therapy (PDRTH) application as a component of the treatment. Positive effect of therapy was estimated basing on the dynamic scintigraphy data with 131I and determination of thyroglobulin level in blood serum. The PDRTH conduction does not improve prognosis of the disease, does not lower the tumor metastasizing frequency to regional lymph nodes and remote organs and does not replace RITH. To achieve positive result in 12.8% of patients with PDRTH more than two courses of RITH were performed, enhancing so the total radiation dosage on the organism. To provide protracted nonrecurrent survival of patients with DFTHGC the radical approach is necessary, envisaging performance of thyroidectomy, the timely conduction of RITH with subsequent suppressive therapy using L-thyroxin.
Chebotareva
E D
ED
Shishkina
V V
VV
Siniuta
B F
BF
Dzhuzha
D A
DA
Cheren'ko
S M
SM
Sheptukha
A I
AI
Gorobeĭko
M B
MB
Ivanov
N A
NA
D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011182:Postoperative Care; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D012189:Retrospective Studies; D012711:Serum Albumin, Radio-Iodinated / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods; D013974:Thyroxine / Q000627:therapeutic use*
D019275:Radiopharmaceuticals; D012711:Serum Albumin, Radio-Iodinated; D013974:Thyroxine