title: Breast conservation treatment in Hong Kong-early results of 203 patients: retrospective study.
abstract: OBJECTIVE
  To study the clinical outcomes of patients with invasive or non-invasive breast cancer after breast conservation treatment.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Clinical oncology department of a public hospital, Hong Kong.
  
  
  METHODS
  Two hundred and three patients who received postlumpectomy radiotherapy at the Pamela Youde Nethersole Eastern Hospital between January 1994 and June 1999.
  
  
  METHODS
  Adjuvant radiotherapy with or without systemic adjuvant treatment.
  
  
  METHODS
  Actuarial local control rate, progression-free survival rate, disease-specific survival rate, and cosmetic score.
  
  
  RESULTS
  The median follow-up was 3.5 years. Two of the 25 patients with carcinoma in situ only developed local recurrence; the 5-year actuarial local control rate was 91.3%. Among the 178 patients with invasive cancer, seven had a local recurrence and 12 developed distant metastases without local failure. The 5-year actuarial local control, progression-free survival, and disease-specific survival rates for patients with invasive cancer were 95.5%, 85.8%, and 95.2%, respectively. The risk of local recurrence was significantly increased for younger patients (age <40 years) and those with positive final margins. Cosmetic scores were rated good to excellent by 95.6% of patients.
  
  
  CONCLUSIONS
  The early clinical outcomes of these patients are comparable to those in large overseas trials, which have demonstrated the equivalence of mastectomy and breast conservation treatment in terms of survival. In addition to mastectomy, with or without breast reconstruction, breast conservation treatment should be offered as an alternative to suitable Chinese women. To maximise local control, further excision or mastectomy is recommended for patients with positive final margins.
authors.affiliation: Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong.
authors.forename: T K
authors.initials: TK
authors.lastname: Yau
authors.forename: Y
authors.initials: Y
authors.lastname: Lau
authors.forename: J
authors.initials: J
authors.lastname: Kong
authors.forename: M W
authors.initials: MW
authors.lastname: Yeung
authors.forename: M
authors.initials: M
authors.lastname: Chan
authors.forename: W M
authors.initials: WM
authors.lastname: Sze
authors.forename: P
authors.initials: P
authors.lastname: Cheung
authors.forename: B H
authors.initials: BH
authors.lastname: Lim
authors.forename: A
authors.initials: A
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D012189:Retrospective Studies