title: Toxicology. Protecting liver from painkiller's lethal dose.
authors.forename: Jean
authors.initials: J
authors.lastname: Marx
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000633:toxicity; D000732:Androstanols / Q000494:pharmacology; D000818:Animals; D016227:Benzoquinones / Q000378:metabolism; D000090702:Constitutive Androstane Receptor; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D062787:Drug Overdose; D005978:Glutathione / Q000378:metabolism; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007097:Imines / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D017114:Liver Failure, Acute / Q000139:chemically induced*; D051379:Mice; D008822:Mice, Transgenic; D010634:Phenobarbital / Q000378:metabolism / Q000494:pharmacology; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D018712:Analgesics, Non-Narcotic; D000732:Androstanols; D016227:Benzoquinones; D000090702:Constitutive Androstane Receptor; D007097:Imines; D007527:Isoenzymes; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C000658:androstan-3-ol; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C496557:Gstp1 protein, mouse; C028473:N-acetyl-4-benzoquinoneimine; D005978:Glutathione; D010634:Phenobarbital