title: Effect of ethanol on human sleep EEG using correlation dimension analysis.
abstract: Our study was designed to investigate the influence of alcohol on sleep using the correlation dimension (D2) analysis. Polysomnography (PSG) was performed in 10 adult human males during a baseline night (BL-N) and an ethanol (0.8 g/kg body weight) night (Et-N). The mean D2 values during the Et-N and BL-N decreased significantly from wakefulness to stages 1, 2, and 3+4 of nonrapid eye movement (non-REM) sleep, and increased during REM sleep. The mean D2 of the sleep electroencephalogram (EEG) during stage 2 during the Et-N was significantly higher than during BL-N. In addition, the mean D2 values of the sleep EEG for the second, third and fourth sleep cycles during the Et-N were significantly higher than during the BL-N. These significant differences between BL-N and Et-N were not recognized by spectral and visual analyses. Our results suggest that D2 is a potentially useful parameter for quantitative analysis of the effect of ethanol on sleep EEGs throughout the entire night.
authors.affiliation: Center of Psychiatry and Neurology, Fukui Prefecture Hospital, Fukui, Japan. t-ko@mx1.fctv.ne.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Madokoro
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wada
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Misaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D000465:Algorithms; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D004569:Electroencephalography / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D017711:Nonlinear Dynamics; D017286:Polysomnography / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol