[Concentration of estrogen and progesterone receptors in normal and neoplastic tissue in patients with laryngeal neoplasm].
The analysis of larynx cancer localisation inside the larynx and hypopharynx indicate that there are some places prone to cancerogenesis. Differences in morbidity, organ localisation and prognosis of larynx cancer can be explained not only by exogenic factors but also by endogenic ones, including hormones. The estrogen (ER) hormone receptor concentration and progesterone (PgR) concentration was estimated in the neoplastic tissue in 18 patients (16 men, 2 women). In the control group, in 10 patients (9 men, 1 women) the concentration receptor was assessed in surrounding, macroscopically unchanged tissue. The quality assessment was done both in cytoplasmatic and nuclear receptors. 6 specimens of neoplastic tissue was taken from vocal folds, 7 from vestibular folds, 2 from subglottic space, 2 from epiglottic petiolus and 1 from pyriform sinus. Control group consist of 10 healthy tissue specimens including 4 taken from the vocal cords. 4 from vestibular folds, 2 from free edge of epiglottis. All samples were examined by pathologist. The concentration of cytoplasmatic and nuclei receptors (ER and PgR) was estimated by immunoenzymatic essay by ER-EIA and PgR-EIA monoclonal antibodies (Abbott). The highest concentration of receptors in larynx cancer was stated in tissue coming from vestibular folds and epiglottic petiolus in healthy objects in the region of vestibular folds.
Piatkowski
Karol
K
Katedra i Klinika Otolaryngologii w Poznaniu.
Kruk-Zagajewska
Aleksandra
A
Thielemann
Anna
A
Kopczyński
Zygmunt
Z
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology; D016022:Case-Control Studies; D002467:Cell Nucleus / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007822:Laryngeal Neoplasms / Q000737:chemistry*; D007830:Larynx / Q000378:metabolism*; D008297:Male; D011960:Receptors, Estrogen / Q000032:analysis* / Q000276:immunology; D011980:Receptors, Progesterone / Q000032:analysis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone