title: Mutation induction and neoplastic transformation in human and human-hamster hybrid cells: dependence on photon energy and modulation in the low-dose range.
abstract: Mutation induction in the HPRT gene of human fibroblasts after irradiation with mammography-like 29 kVp or 200 kVp x-rays shows radiohypersensitivity for doses smaller than approximately 0.5 Gy. Similarly, mutation induction in the CD 59 gene on human chromosome 11 in A(L) cells shows radiohypersensitivity for doses smaller than approximately 0.5 Gy after exposure to 200 kVp x-rays, but not after irradiation with low-filtered 30 kVp x-rays. The RBE values of 29 and 30 kVp x-rays relative to 200 kVp x-rays are strongly dose dependent. For neoplastic transformation of human hybrid (CGL1) cells after irradiation with 29 or 200 kVp x-rays or 60Co gamma rays a linear-quadratic dose relationship was observed with RBE values of approximately four and eight for mammography relative to 200 kVp x-rays and 60Co gamma rays, respectively.
authors.affiliation: Abt. Klin. Strahlenbiologie und Klin. Strahlenphysik, Universität Göttingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Frankenberg
authors.forename: M
authors.initials: M
authors.lastname: Frankenberg-Schwager
authors.forename: I
authors.initials: I
authors.lastname: Garg
authors.forename: E
authors.initials: E
authors.lastname: Pralle
authors.forename: D
authors.initials: D
authors.lastname: Uthe
authors.forename: B
authors.initials: B
authors.lastname: Greve
authors.forename: E
authors.initials: E
authors.lastname: Severin
authors.forename: W
authors.initials: W
authors.lastname: Göhde
mesh_terms: D000818:Animals; D018957:CD59 Antigens / Q000235:genetics; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D006822:Hybrid Cells; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D009154:Mutation / Q000528:radiation effects*; D011829:Radiation Dosage; D012062:Relative Biological Effectiveness; D014965:X-Rays
chemical_list: D018957:CD59 Antigens; D007041:Hypoxanthine Phosphoribosyltransferase