title: Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination.
abstract: Miconazole is reduced at mercury electrode above pH 6 involving organometallic compound formation, responsible for an anomalous polarographic behavior. The electrodic process presents a large contribution of the adsorption effects. The drug can be determined by cathodic stripping voltammetry from 8.0 x 10(-8) to 1, 5 x 10(-6) molL-1 in Britton-Robinson buffer pH 8.0, when pre-accumulated for 30s at an accumulation potential of 0V. A relative standard deviation of 3.8% was obtained for ten measurements of 1.0 x 10(-7) molL-1 miconazole in B-R buffer pH 8.0 and a limit detection of 1, 7 x 10(-8) molL-1 was determined using 60s of deposition time and scan rate of 100 mVs-1. The proposed method is simple, precise and it was applied successfully for the determination of the miconazole in pure form and in commercial formulations, showing mean recoveries of 99.7-98.4%.
authors.affiliation: Instituto de Química, Universidade Estadual Paulista, 14801-970, Araraquara, SP, Brazil.
authors.forename: Francisco C
authors.initials: FC
authors.lastname: Pereira
authors.forename: Nelson R
authors.initials: NR
authors.lastname: Stradiotto
authors.forename: Maria Valnice B
authors.initials: MV
authors.lastname: Zanoni
mesh_terms: D000935:Antifungal Agents / Q000032:analysis / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D008628:Mercury; D008825:Miconazole / Q000032:analysis / Q000737:chemistry*; D013053:Spectrophotometry / Q000379:methods
chemical_list: D000935:Antifungal Agents; D008825:Miconazole; D008628:Mercury