title: Changes in size of periarthritis calcifications in patients with painful shoulder treated with injectable disodium-clodronate.
abstract: Calcific periarticular disease is characterized by the deposition of calcium phosphate crystals in many tendons and particularly in the rotator cuff tendons. Calcifications of any size may be accompanied by painful shoulder syndrome and tendon tears. Ecographic assessment of changes in the size of calcifications may be a marker of tissue changes in evolving shoulder periarthropathies. The aim of this study was to compare variations in pain and ultrasound dimensions in the calcifications in the tendons of the rotator cuff in patients treated with disodium-clodronate compared with those treated with paracetamol and nimesulide. In all groups, pain reduction occurred over a 6-month period, but was significantly greater in patients administered disodium-clodronate than in those administered nimesulide or paracetamol. A significant reduction in the size of calcifications was also observed in all three groups, but this reduction was more marked in the disodium-clodronate group.
authors.affiliation: Istituto Bruzzone, Rheumatology Medical School, Department of Endocrinological and Metabolic Diseases, University of Genoa, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Monteforte
authors.forename: G
authors.initials: G
authors.lastname: Rovetta
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004002:Clodronic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010489:Periarthritis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012785:Shoulder Joint / Q000000981:diagnostic imaging*; D013449:Sulfonamides / Q000627:therapeutic use; D013577:Syndrome; D013710:Tendons / Q000000981:diagnostic imaging; D000267:Tissue Adhesions / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D004002:Clodronic Acid; D000082:Acetaminophen; C012655:nimesulide