title: Chlamydia pneumoniae in community-acquired pneumonia: seven years of experience.
abstract: OBJECTIVE
  To determine the prevalence of Chlamydia pneumoniae in community-acquired pneumonia during a period of seven years.
  
  
  METHODS
  Serum samples from 311 patients with pneumonia were evaluated using microimmunofluorescence assay to detect C. pneumoniae -specific IgG and IgM antibodies.
  
  
  RESULTS
  Thirty nine patients (12.5%) complied with the diagnostic criteria of acute C. pneumoniae infection (a four-fold rise in the titer of IgG antibody, or a single IgG titer > or = 1:512, or a single IgM titer > or = 1:16). All patients were diagnosed as having pneumonia. Co-infection with other respiratory tract pathogens was found in four patients.
  
  
  CONCLUSIONS
  C. pneumoniae is an important cause of pneumonia also in our area. Pneumonia due to this bacterium occurs in the cold months and in early spring; in addition we have observed periods of increased incidence of one years duration and periods of low incidence lasting one-two years. Therapy with macrolides and levofloxacin was effective in all patients with C. pneumoniae infection.
authors.affiliation: Department of Internal Medicine and Public Health--Hygiene Section, University of Bari, Italy. r.monno@igieneseconda.uniba.it
authors.forename: R
authors.initials: R
authors.lastname: Monno
authors.forename: D
authors.initials: D
authors.lastname: De Vito
authors.forename: G
authors.initials: G
authors.lastname: Losito
authors.forename: G
authors.initials: G
authors.lastname: Sibilio
authors.forename: A
authors.initials: A
authors.lastname: Costi
authors.forename: L
authors.initials: L
authors.lastname: Fumarola
authors.forename: A
authors.initials: A
authors.lastname: D'Aprile
authors.forename: P
authors.initials: P
authors.lastname: Marcuccio
mesh_terms: D000900:Anti-Bacterial Agents / Q000145:classification / Q000627:therapeutic use; D023521:Chlamydophila Infections / Q000453:epidemiology* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000472:pathogenicity; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D015994:Incidence; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012698:Serologic Tests
chemical_list: D000900:Anti-Bacterial Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M