Facilely accessible multidrug resistance modulator derived from sucrose.
Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3',4'-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.
Murakami
Nobutoshi
N
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Tamura
Satoru
S
Iwata
Etsuko
E
Aoki
Shunji
S
Akiyama
Shin-ichi
S
Kobayashi
Motomasa
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006801:Humans; D013329:Structure-Activity Relationship; D013395:Sucrose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014700:Verapamil / Q000494:pharmacology
D013395:Sucrose; D014700:Verapamil