title: Composite germ cell tumor and B-cell non-Hodgkin's lymphoma arising in the sella turcica.
abstract: We report the case of a composite malignant neoplasm consisting of germ cell tumor and B-cell non-Hodgkin's lymphoma occurring in the sella turcica of a young girl who presented with hypopituitarism. Routine hematoxylin and eosin-stained sections of a resected suprasellar tumor demonstrated a neoplasm composed of 2 distinct morphologies. A panel of immunohistochemical markers was used to confirm the morphologic impression of germinoma (cytokeratin AE1/AE3-CAM 5.2, cytokeratin 7, neuron-specific enolase, and focally placental alkaline phosphatase positive) and mature B-cell lymphoma (CD20 positive; pancytokeratin, placental alkaline phosphatase, and terminal deoxynucleotidyl transferase negative). To the best of our knowledge, this is the first reported case of such a composite tumor in the central nervous system.
authors.affiliation: Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109, USA.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Valdez
authors.forename: Paul
authors.initials: P
authors.lastname: McKeever
authors.forename: William G
authors.initials: WG
authors.lastname: Finn
authors.forename: Stephen
authors.initials: S
authors.lastname: Gebarski
authors.forename: Bertram
authors.initials: B
authors.lastname: Schnitzer
mesh_terms: D014408:Biomarkers, Tumor; D001859:Bone Neoplasms / Q000473:pathology* / Q000503:physiopathology; D002454:Cell Differentiation; D002648:Child; D005260:Female; D018237:Germinoma / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000503:physiopathology; D012658:Sella Turcica / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor