title: A reinvestigation of maximal signal drop in dynamic susceptibility contrast magnetic resonance imaging.
abstract: OBJECTIVE
  The purpose of this study was to reevaluate the usefulness of relative maximum signal drop (rMSD), as compared to relative cerebral blood volume (rCBV) and cerebral blood flow (rCBF), in dynamic susceptibility contrast magnetic resonance imaging (MRI).
  
  
  METHODS
  Twenty-five patients (11 with cerebral gliomas and 14 with infarcts of middle cerebral arterial territories) were included. The rMSD values were measured from 83 regions of interest and compared with measurements from corresponding rCBV and rCBF maps.
  
  
  RESULTS
  In stroke patients, rMSD correlated strongly with rCBF (r = 0.96) but only fairly with rCBV (r = 0.69). The absence of an association between rMSD and rCBV was evident in regions of increased contrast bolus dispersion. In glioma patients, the correlation of rMSD with rCBF (r = 0.85) was similar to that of rMSD with rCBV (r = 0.80). The interparameter associations were well predicted by computer simulations.
  
  
  CONCLUSIONS
  The authors conclude that rMSD is as useful as rCBF under a variety of pathophysiological conditions, whereas in conditions with normal mean transit time, such as brain tumors, rMSD provides equivalent blood volume information to rCBV. The simplicity of rMSD maps could lead to the increased use of perfusion-weighted MRI.
authors.affiliation: Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan.
authors.forename: Yi-Jui
authors.initials: YJ
authors.lastname: Liu
authors.forename: Hsiao-Wen
authors.initials: HW
authors.lastname: Chung
authors.forename: Ing-Jye
authors.initials: IJ
authors.lastname: Huang
authors.forename: Fu-Nien
authors.initials: FN
authors.lastname: Wang
authors.forename: Shy-Chyi
authors.initials: SC
authors.lastname: Chin
authors.forename: Chang-Shin
authors.initials: CS
authors.lastname: Lee
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D020520:Brain Infarction / Q000503:physiopathology*; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D003287:Contrast Media; D005260:Female; D005910:Glioma / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media