[Annexin I-induced aggregation of human neutrophil gelatinase granules].
The ability of neutrophil cytosol to induce the aggregation of gelatinase granules of human neutrophils was studied. The cytosol was found to induce the Ca(2+)-dependent aggregation of granules. The stimulatory effect of cytosol was considerably reduced in the presence of the monoclonal antibody recognizing annexin I. Annexin I is a mediator of Ca(2+)-dependent aggregation of gelatinase granules and probably participate in granule secretion.
Nabokina
S M
SM
Ogarev Mordovian State University, ul. Bolshevistskaya 68, Saransk, 430000 Russia.
Revin
V V
VV
D017305:Annexin A1 / Q000276:immunology / Q000378:metabolism*; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002122:Calcium Chloride / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D003600:Cytosol / Q000502:physiology; D018093:Gelatinases / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000648:ultrastructure*
D017305:Annexin A1; D000911:Antibodies, Monoclonal; D018093:Gelatinases; D002122:Calcium Chloride; D002118:Calcium