Elevated immunoreactive-adrenomedullin levels in the aqueous humor of patients with uveitis and vitreoretinal disorders.
To clarify possible involvement of adrenomedullin in the pathophysiology of inflammation of eyes, we measured immunoreactive-adrenomedullin concentrations in the aqueous humor and plasma obtained from 14 control subjects and 56 patients with uveitis or vitreoretinal disorders. Immunoreactive-adrenomedullin levels in the aqueous humor were significantly elevated in patients with active uveitis, proliferative vitreoretinopathy and proliferative diabetic retinopathy, as compared with control subjects. The plasma immunoreactive-adrenomedullin levels were not significantly correlated with the aqueous humor levels. These findings suggest that adrenomedullin produced locally in the eyes is involved in the pathophysiology of uveitis and some proliferative vitreoretinal disorders.
Udono
Tetsuo
T
Department of Ophthalmology, Tohoku University School of Medicine, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
Takahashi
Kazuhiro
K
Abe
Toshiaki
T
Shibahara
Shigeki
S
Tamai
Makoto
M
D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood / Q000378:metabolism*; D014605:Uveitis / Q000378:metabolism*; D018630:Vitreoretinopathy, Proliferative / Q000378:metabolism*
D010455:Peptides; D053607:Adrenomedullin; D015740:Calcitonin Gene-Related Peptide