Brain stem GABA receptor functional regulation during rat liver cell proliferation.
GABAergic alterations in brain stem during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN)-induced direct hyperplasia, and N-nitrosodiethylamine (NDEA)-induced neoplasia in liver were investigated. GABA content decreased in brain stem of PH- and NDEA-treated rats while it increased in LN-treated rats. GABA(A) receptor number and affinity in brain stem membrane preparations of rats showed a significant decrease in PH- and NDEA-treated rats. The GABA(B) receptor number increased in PH- and NDEA-treated rats with an increase in affinity. The results of the present study indicate that liver cell proliferation is influencing the brain stem GABAergic neurotransmission and these changes regulate the hepatic proliferation through the sympathetic stimulation.
Biju
Mangatt P
MP
Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, India.
Pyroja
Sulaiman
S
Rajeshkumar
Neelimmathara V
NV
Paulose
Cheramadathikudyil S
CS
D000818:Animals; D001418:Baclofen / Q000378:metabolism; D001933:Brain Stem / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid; D008099:Liver / Q000166:cytology*; D008297:Male; D011485:Protein Binding; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000378:metabolism / Q000502:physiology*
D018079:Receptors, GABA; D001418:Baclofen