title: [Analysis of the proteomic changes of the serum of the Smad3 targeted deficient mice].
abstract: We have studied the proteomic changes of the serum of the Smad3 targeted deficient mice using 2-DE and PMF approaches. 7 proteins expressed at different level in wild type mice and the Smad3 deficient mice were identified. These results would benefit the research on diagnosis and therapy of osteoarthritis and provided clues to studying the important function of Smad3 mediated TGF-beta signals during the skeletal development.
authors.affiliation: Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
authors.forename: Zhen-Ming
authors.initials: ZM
authors.lastname: Hao
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.forename: Wan-Tao
authors.initials: WT
authors.lastname: Ying
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Qian
authors.forename: Cui-Fen
authors.initials: CF
authors.lastname: Huang
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000097:blood* / Q000172:deficiency / Q000235:genetics; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D005838:Genotype; D051379:Mice; D018345:Mice, Knockout; D010449:Peptide Mapping; D020543:Proteome / Q000032:analysis*; D051900:Smad3 Protein; D015534:Trans-Activators / Q000097:blood* / Q000172:deficiency / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D020543:Proteome; D051900:Smad3 Protein; C497791:Smad3 protein, mouse; D015534:Trans-Activators