title: New chromosome rearrangement in acute lymphoblastic leukemia.
abstract: Cytogenetic findings in leukemia can be used in the diagnosis, prognosis, and in the definition of different subgroups. The most common chromosome abnormalities associated with mature B-cell acute lymphoblastic leukemia (ALL) are t(8;14), t(8;22), t(2;8), and partial duplication of 1q. Various abnormalities involving chromosome 1 have also been reported in ALL. We present a 16-year-old male with mature B-cell ALL whose cytogenetic analysis of bone marrow showed the karyotype of 46,XY,t(8;14)(q24;q32), -15,der(1;15)(p10;q10). The case presented here carries one of the most common abnormalities, t(8;14) (q24;q32), and a new rearrangement, der(1;15)(p10;q10), which has not been described to date in mature B-cell ALL.
authors.affiliation: Department of Medical Biology, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey.
authors.forename: Cumhur
authors.initials: C
authors.lastname: Gündüz
authors.forename: Ozgür
authors.initials: O
authors.lastname: Coğulu
authors.forename: Nazan
authors.initials: N
authors.lastname: Cetingül
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kantar
authors.forename: Tufan
authors.initials: T
authors.lastname: Cankaya
authors.forename: Cihangir
authors.initials: C
authors.lastname: Ozkinay
authors.forename: Ferda
authors.initials: F
authors.lastname: Ozkinay
mesh_terms: D000293:Adolescent; D001402:B-Lymphocytes / Q000473:pathology; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics