Electrical stimulation for epilepsy: stimulation of hippocampal foci.
Subacute and chronic continuous electrical stimulation at the epileptic focus in the hippocampus or parahippocampal cortex at 130 Hz, 0.21-1.0 ms, 2.5-3.5 V (about 200-300 microA) induces a decrease in focal EEG epileptic interictal activity and also in the occurrence of clinical seizures. This may represent an alternative for the treatment of temporal lobe seizures originated in bilateral independent temporal lobe foci or occurring in patients where one is uncertain whether memory deficit might result from ablative procedures.
Velasco
F
F
Unit for Stereotactic and Functional Neurosurgery, General Hospital, Mexico City, Mexico. fvelazco@netservice.com.mx
Velasco
M
M
Velasco
A L
AL
Menez
D
D
Rocha
L
L
D004599:Electric Stimulation Therapy; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon
D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A