title: [Effects of Helicobacter pylori infection on porcine gastric epithelial cell proliferation].
abstract: OBJECTIVE
  To investigate the association between porcine gastric epithelial cell proliferation and Helicobacter pylori (Hp) infection.
  
  
  METHODS
  Animal models of gastritis associated with Hp infection were established using "Chinese No.1 pigs". The expressions of proliferating cell nuclear antigen (PCNA) and DNA polyploid content in porcine gastric epithelial cells were quantitatively assayed by means of immunohistochemistry and Feulgen stain respectively.
  
  
  RESULTS
  The values of PCNA labeling index (LI) in the porcine gastric epithelial cells of the experimental group were significantly higher than those of the control group (40.95+/-3.60 vs 29.4+/-12.82, P<0.01). The DNA diploid or approximate diploid content in the gastric mucosa of the pigs was significantly lower (70.78% vs 90.65%, P<0.01), but the proliferation polyploid and non-doubleploid of DNA significantly higher in the experimental group than in the control group (P<0.01).
  
  
  CONCLUSIONS
  Hp infection may play a role to enhance the proliferation of gastric epithelial cells in pigs.
authors.affiliation: Department of Gastroenterology, General Hospital of Guangzhou Command, Guangzhou 510010, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Song
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Sun
authors.forename: Xiao-Rang
authors.initials: XR
authors.lastname: Huang
authors.forename: Ri-Quan
authors.initials: RQ
authors.lastname: Lai
authors.forename: Zhu-Quan
authors.initials: ZQ
authors.lastname: Luo
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Deng
mesh_terms: D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D005753:Gastric Mucosa / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori / Q000502:physiology*; D013552:Swine