Signal transduction by type I interferons.
The two classes of interferons, type I (IFNalpha, IFNbeta, IFNomega, and IFNtau) and type II (IFNgamma) are pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on their target cells. This article summarizes the advances made in elucidating the molecular events that mediate the biological responses to type I interferons.
David
Michael
M
Division of Biological Sciences, and UCSD Cancer Center, University of California, San Diego 92093-0322, USA. midavid@ucsd.edu
D021581:Active Transport, Cell Nucleus; D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D008565:Membrane Proteins; D008745:Methylation; D008954:Models, Biological; D016328:NF-kappa B / Q000502:physiology; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D007370:Interferon Type I; D008565:Membrane Proteins; D016328:NF-kappa B; D017471:Receptors, Interferon; D015534:Trans-Activators; D053633:Receptor, Interferon alpha-beta; D011505:Protein-Tyrosine Kinases