Cerebellar symptoms heralding bilirubin encephalopathy in Crigler-Najjar syndrome.
Children with Crigler-Najjar syndrome type I are at increased risk for neurologic deficits. Cerebellar symptoms are not prominent and appear in adolescent or adult patients with this syndrome. We report a 2-year-old female with Crigler-Najjar syndrome type I who presented severe cerebellar symptoms revealing bilirubin encephalopathy. The patient improved slowly with the duration of phototherapy. Cerebellar symptoms can be the initial manifestation of kernicterus in children with Crigler-Najjar syndrome type I.
Tabarki
Brahim
B
Service de Pédiatrie, Hôpital Farhat-Hached, Sousse, Tunisia.
Khalifa
Monia
M
Yacoub
Moncef
M
Tlili
Kalthoum
K
Essoussi
Ahmed S
AS
D001921:Brain / Q000473:pathology; D002526:Cerebellar Diseases / Q000175:diagnosis / Q000235:genetics*; D002531:Cerebellum / Q000473:pathology; D002675:Child, Preschool; D003414:Crigler-Najjar Syndrome / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000235:genetics*; D007567:Jaundice, Neonatal / Q000175:diagnosis / Q000235:genetics*; D007647:Kernicterus / Q000175:diagnosis / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination