Tupuseleiamides and basiliskamides, new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolate obtained from a tropical marine habitat.
Laboratory cultures of PNG 276, a Bacillus laterosporus isolate obtained from coastal waters off Papua New Guinea, have been shown to produce the novel metabolites basiliskamide A (1), basiliskamide B (2), tupuseleiamide A (3), and tupusleiamide B (4). The structures of 1 to 4 were elucidated by analysis of spectroscopic data and chemical degradation. Basiliskamides A (1) and B (2) show potent in vitro anti-Candida activity.
Barsby
Todd
T
Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, 2036 Main Mall, Vancouver, Canada.
Kelly
Michael T
MT
Andersen
Raymond J
RJ
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000378:metabolism*; D004151:Dipeptides / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D008386:Marine Biology; D011487:Protein Conformation; D013057:Spectrum Analysis
D000935:Antifungal Agents; D004151:Dipeptides