title: Isolated cardiac recurrence of acute lymphoblastic leukemia characterized by t(11;19) two years after unrelated allogeneic bone marrow transplantation.
abstract: A 33-year-old male presented with acute lymphoblastic leukemia (ALL) characterized by translocation (11;19)(q23;p13.3). He received an allogeneic bone marrow transplant from a matched unrelated donor. Two years later his disease relapsed with an isolated intracardiac mass, presenting as right heart failure. He had no evidence of concomitant relapse in the bone marrow. Tumor cytogenetics revealed clonal evolution with the karyotype 46,XY,t(3;16)(q23;p13),t(11;19)(q23;p13.3), the chromosome 16 breakpoint involving the band where the genes for multidrug resistance-associated protein and CREB binding protein are known to reside. To our knowledge, this is the first report of an isolated extramedullary relapse of ALL in the heart.
authors.affiliation: Department of Hematology, Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: Tonya L
authors.initials: TL
authors.lastname: Wright
authors.forename: Peter G
authors.initials: PG
authors.lastname: Bardy
authors.forename: Patrick
authors.initials: P
authors.lastname: Disney
authors.forename: Sarah
authors.initials: S
authors.lastname: Moore
authors.forename: Noemi
authors.initials: N
authors.lastname: Horvath
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D004452:Echocardiography; D006338:Heart Neoplasms / Q000235:genetics / Q000556:secondary*; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology*; D012008:Recurrence; D013997:Time Factors; D014178:Translocation, Genetic / Q000235:genetics*; D014184:Transplantation, Homologous