title: Initial in vivo results of the new Medtronic Advantage(TM) bileaflet valve in aortic position and comparison to the SJM.
abstract: The present study investigated the Medtronic Advantage (MA) bileaflet valve in an animal model and compared the results to the St. Jude Medical (SJM) valve. Systolic performance and coronary artery flow in different orientations were studied.A rotation device holding either a MA or SJM aortic valve size 23 mm was implanted into eight pigs. Transvalvular pressure gradients and ventricular dimensions were investigated with the valves in different orientations. Coronary artery flow was measured at normal and high cardiac output. Orientation significantly influenced the hemodynamic performance of both valves. The best results for both valves were obtained with one orifice proximal to the right cusp. Pressure gradients and ventricular dimensions of the MA corresponded to the SJM. Coronary artery flow was higher for the MA. The systolic performance of the new MA bileaflet valve was similar to the SJM. During diastole, the MA showed significantly higher LAD coronary flow.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Johann-Wolfgang-Goethe University, Frankfurt/Main, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Kleine
authors.forename: Armin A
authors.initials: AA
authors.lastname: Klesius
authors.forename: Mirella
authors.initials: M
authors.lastname: Scherer
authors.forename: Ulf
authors.initials: U
authors.lastname: Abdel-Rahman
authors.forename: Anton
authors.initials: A
authors.lastname: Moritz
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000503:physiopathology / Q000601:surgery*; D001794:Blood Pressure; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006439:Hemodynamics; D011474:Prosthesis Design; D012399:Rotation; D013552:Swine