title: An acid-catalyzed macrolactonization protocol.
abstract: [reaction: see text] An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol % [RuCl(2)(p-cymene)](2) in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: John D
authors.initials: JD
authors.lastname: Chisholm
mesh_terms: D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D007783:Lactones / Q000737:chemistry*
chemical_list: D000143:Acids; D007783:Lactones