[Expression of proliferating cell nuclear antigen in craniopharyngioma and tumor recurrence].
OBJECTIVE
To investigate proliferating cell nuclear antigen labeling indices (PCNA-LI) in craniopharyngiomas in association with tumor recurrence.


METHODS
Immunohistochemistry was employed to examine the expression of PCNA in 43 craniopharyngioma samples of different pathological types, and the relationship between PCNA-LI and tumor recurrence was evaluated.


RESULTS
PCNA-LI was much higher in adamantinous tumors than in squamous papillary tumors that did not give rise to postoperative recurrence. Although PCNA-LI was higher in the recurrent lesions than in the primary tumor in adamantinoma group, the difference was not statistically significant.


CONCLUSIONS
Craniopharyngioma cells with different pathological features may possess varied proliferating potentials, and active proliferation is the main factor for postoperative recurrence of adamantinoma.
Pan
Jun
J
Department of Neurosurgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Qi
Song-Tao
ST
Deng
Yong-Jian
YJ
Ding
Yan-Qing
YQ
Peng
Lin
L
Li
Xiao-Qiang
XQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D012008:Recurrence
D018809:Proliferating Cell Nuclear Antigen