title: Genetic susceptibility to aminoglycoside ototoxicity: how many are at risk?
abstract: OBJECTIVE
  To assess the occurrence of two mutations associated with susceptibility to aminoglycoside ototoxicity.
  
  
  METHODS
  Genetic analysis of anonymized, residual diagnostic specimens.
  
  
  RESULTS
  One occurrence of the A1555G mutation and seven occurrences of the 961delT + C(n) nucleotide change were found. Two previously unreported sequence changes, T961G and 956-960insC, were also found in six and five specimens, respectively.
  
  
  CONCLUSIONS
  Genetic susceptibility to aminoglycoside ototoxicity may be more common than previously suspected. Further study of the 961delT + C(n) mutation is recommended to confirm its role in aminoglycoside ototoxicity and assess penetrance and variability with and without exposure to aminoglycoside antibiotics.
authors.affiliation: The Bobby R. Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Hsiao-Yuan
authors.initials: HY
authors.lastname: Tang
authors.forename: Eldridge
authors.initials: E
authors.lastname: Hutcheson
authors.forename: Susan
authors.initials: S
authors.lastname: Neill
authors.forename: Margaret
authors.initials: M
authors.lastname: Drummond-Borg
authors.forename: Michael
authors.initials: M
authors.lastname: Speer
authors.forename: Raye Lynn
authors.initials: RL
authors.lastname: Alford
mesh_terms: D000483:Alleles; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D044383:Black People / Q000235:genetics; D004247:DNA / Q000097:blood / Q000235:genetics; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000737:chemistry; D003638:Deafness / Q000139:chemically induced* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D015997:Neonatal Screening; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics; D001741:Black or African American
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D017931:DNA Primers; D004247:DNA