Effect of diclofenac on cerebral blood flow velocity in patients with supratentorial tumours.
BACKGROUND
The aim of this investigation was to determine the effects of diclofenac on cerebral blood flow. Middle cerebral artery blood flow velocity was measured in nine patients with supratentorial tumours.


METHODS
Using a transcranial Doppler ultrasound, we measured the baseline mean and systolic cerebral blood flow velocity. Measurements were repeated following administration of diclofenac 75 mg i.v.


RESULTS
There was no significant change in cerebral blood flow velocity. All other physiological variables remained constant.


CONCLUSIONS
Diclofenac does not cause a significant change in cerebral blood flow velocity in patients with supratentorial tumours.
Jones
S J
SJ
Department of Anaesthesia, St George's Hospital, Blackshaw Road, London SW17 0NE, UK.
Dinsmore
J
J
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004008:Diclofenac / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D015173:Supratentorial Neoplasms / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac