Increases in the release and metabolism of serotonin in nucleus parafascicularis thalami following systemically administered morphine in the rat.
The effects of systemically administered morphine on the release and metabolism of serotonin (5-HT) in nucleus parafascicularis thalami were evaluated using in vivo microdialysis. The extracellular concentration of 5-HT and its major metabolite 5-hydroxyindoleacetic acid were increased in a dose-dependent manner following the subcutaneous administration of 2.5 and 5 mg/kg morphine sulfate. These results are consistent with findings that the antinociceptive action of morphine is partially mediated through the action of 5-HT within nucleus parafascicularis.
Munn
Elizabeth M
EM
Department of Psychology, 71 W Warren Avenue, Wayne State University, Detroit, MI 48202, USA.
Borszcz
George S
GS
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry; D005110:Extracellular Space / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D020646:Intralaminar Thalamic Nuclei / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D012701:Serotonin / Q000378:metabolism*; D014828:Vocalization, Animal / Q000502:physiology
D000701:Analgesics, Opioid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009020:Morphine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin