title: ent-Kaurane diterpenoids from the leaves of Isodon xerophilus.
abstract: From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1 - 3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC(50) = 0.09 and 0.32 microg/ml, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Heilongtan, Kunming, Yunnan, P. R. China.
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Yao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D037602:Isodon; D020014:K562 Cells / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts