A review of gene expression patterns in the malformed brain.
Major advances in the identification of genes expressed in malformation-associated epileptic disorders have been made. Some of these changes reflect the complex gene interactions necessary for proper neurodevelopment, whereas others suggest specific synaptic aberrations that could result in a hyperexcitable, and ultimately, epileptic condition. Here we review reported changes in gene expression associated with a malformed brain, with particular emphasis on how these changes provide clues to seizure genesis.
Paredes
Mercedes F
MF
Baraban
Scott C
SC
D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000196:embryology / Q000378:metabolism / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000096:biosynthesis / Q000235:genetics; D003599:Cytoskeleton / Q000648:ultrastructure; D004827:Epilepsy / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D051381:Rats; D013569:Synapses / Q000502:physiology / Q000648:ultrastructure; D014402:Tuberous Sclerosis / Q000150:complications / Q000235:genetics
D003598:Cytoskeletal Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins