Pharmacokinetics and pharmacodynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate.
The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.
Trampuz
Andrej
A
Division of Infectious Diseases, Departments of Internal Medicine and Research, University Hospitals, Basel, Switzerland.
Laifer
Gerd
G
Wenk
Markus
M
Rajacic
Zarko
Z
Zimmerli
Werner
W
D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D019540:Area Under Curve; D001770:Blood Bactericidal Activity; D005122:Exudates and Transudates / Q000187:drug effects / Q000382:microbiology*; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006098:Granulocytes / Q000187:drug effects / Q000382:microbiology*; D006207:Half-Life; D012867:Skin / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013608:Tablets, Enteric-Coated
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D013608:Tablets, Enteric-Coated; D000077734:Gatifloxacin