Erythromycin resistance in Borrelia burgdorferi.
Susceptibility testing of laboratory strains and clinical isolates of Borrelia burgdorferi indicates that resistance to erythromycin is present in them. Evaluation of the MICs, minimal bactericidal concentrations, and kinetics of bacterial killing of erythromycin suggests that this resistance is increased by preexposure to the antibiotic, is dependent on inoculum size, and may be the result of selection of subpopulations of bacterial cells with increased resistance.
Terekhova
Darya
D
Departments of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA.
Sartakova
Marina L
ML
Wormser
Gary P
GP
Schwartz
Ira
I
Cabello
Felipe C
FC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D025065:Borrelia burgdorferi / Q000187:drug effects* / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008193:Lyme Disease / Q000382:microbiology; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D004917:Erythromycin