title: Intracranial hemorrhage in herpes simplex encephalitis: an unusual presentation.
abstract: We describe a 14-month-old patient with atypical presentation of herpes simplex encephalitis. She initially presented with fever, lethargy, seizures, and large hemorrhages in the right parietal lobe, and clinical findings suggestive of a hypercoagulable state. The etiology of coagulation abnormality was not identified, although it was suggested as a possible causative factor in severe bleeding along with acute neuronal lysis as a result of infection. Although large intracerebral hemorrhages are occasionally described with systemic herpes infection, this presentation is unusual beyond the infant period.
authors.affiliation: Department of Pediatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii 96826, USA.
authors.forename: Guliz
authors.initials: G
authors.lastname: Erdem
authors.forename: Paula A
authors.initials: PA
authors.lastname: Vanderford
authors.forename: Robert D
authors.initials: RD
authors.lastname: Bart
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D001780:Blood Coagulation Tests; D002540:Cerebral Cortex / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination / Q000187:drug effects; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D014057:Tomography, X-Ray Computed
chemical_list: D000212:Acyclovir