title: New marine diterpenoids from the Okinawan soft coral Clavularia koellikeri.
abstract: Chemical investigation of the Okinawan soft coral Clavularia koellikeri resulted in the isolation of two new cembrane diterpenoids (1 and 2) and one new dollabelane diterpenoid, 3. Their structures were determined on the basis of the results of spectroscopic analysis. Compounds 1 and 3 were examined for in vitro growth-inhibition effects toward tumor cells.
authors.affiliation: Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Iwashima
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Iguchi
authors.forename: Takao
authors.initials: T
authors.lastname: Yamori
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D015394:Molecular Structure; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes