title: Clinical and laboratory characteristics of infective endocarditis when associated with spondylodiscitis.
abstract: Spondylodiscitis is rarely observed in association with infective endocarditis (IE). In the study presented here, 92 cases of definite IE were examined. Spondylodiscitis was present in 14 (15%) cases. The mean age of patients with spondylodiscitis was 69.1+/-13.6 years (range, 33-87 years). The male-to-female ratio was 8:6. Predisposing heart disease was found in nine (64.3%) cases. Back pain was reported in all cases. Spondylodiscitis was diagnosed before endocarditis in all cases. The infection affected the lumbar spine in 10 (71%) cases. A bacterium was isolated in all cases: group D Streptococcus ( n=5; 35.7%), coagulase-negative Staphylococcus ( n=4; 28.6%), and others ( n=5). Endocarditis affected predominantly the aortic valve (43%). The outcome was favourable in 12 cases. No differences in clinical features, evolution of disease, or laboratory values were found between IE patients with and IE patients without spondylodiscitis. Spondylodiscitis does not appear to worsen prognosis of IE, although the need for cardiac valve replacement seems to be more frequent in IE patients with spondylodiscitis. IE should be included in the differential diagnosis in patients with infectious spondylodiscitis and risk factors for endocarditis. In such patients, echocardiography should be performed routinely.
authors.affiliation: Department of Internal Medicine and Infectious Diseases, CHU la Milétrie, Avenue J. Coeur, 86021 Poitiers Cedex, France. g.lemoal@chu-poitiers.fr
authors.forename: G
authors.initials: G
authors.lastname: Le Moal
authors.forename: F
authors.initials: F
authors.lastname: Roblot
authors.forename: M
authors.initials: M
authors.lastname: Paccalin
authors.forename: P
authors.initials: P
authors.lastname: Sosner
authors.forename: C
authors.initials: C
authors.lastname: Burucoa
authors.forename: P
authors.initials: P
authors.lastname: Roblot
authors.forename: B
authors.initials: B
authors.lastname: Becq-Giraudon
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D016470:Bacteremia / Q000175:diagnosis / Q000453:epidemiology*; D002574:Cervical Vertebrae; D015897:Comorbidity; D015299:Discitis / Q000453:epidemiology* / Q000382:microbiology; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D011336:Probability; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000900:Anti-Bacterial Agents