[The smooth tracking test and rotation stimulation test in disorders of the vestibular system caused by carbamazepine].
The examination was carried out in 10 healthy volunteers of both sexes, of the average age of 32.5 years, of the average weight of 77.4 kg. Seven volunteers were males. After dosage of 800 mg of carbamazepine in 2/7 volunteers the finding was unchanged, in 3/7 second stage disturbance was found and in 2/7 third stage of disturbance in the smooth tracking test was found. After the administration of 1200 mg the findings were worse, 1/10 volunteers had unchanged findings compared with control dose, 6/10 had second stage disturbance of the smooth tracking test, 1/10 third stage and 2/10 forth stage disturbance. After dosages of 800 mg and 1200 mg there was a statistically significant difference disturbance of the smooth tracking test finding compared to control. After dosage of 800 mg of carbamazepine in 1/7 of volunteers the finding was without significant changes in the torsion chair test, in 3/7 changes were minimal, in 2/7 changes were moderate and in 1/7 of volunteers changes were high. In 5/10 of volunteers there was third stage of disturbance after dosage of 1200 mg of carbamazepine and in the same group 4/10 of volunteers had fourth stage of disturbance. In all cases after 800 mg and 1200 mg of carbamazepine pathologic vestibular habituation appeared. With increased dosage of carbamazepine the finding of the torsion chair test and smooth tracking test showed increased disturbance level. Disturbance of balance primary was on the central level and after higher therapeutic carbamazepine dose peripheral part of vestibular system disappeared.
Kljajić
Vladimir
V
Department of Oto-Rhino-Laryngology, Clinical Centre, Novi Sad.
Milosević
Dusan
D
Jovićević
Jasna
J
Vlaski
Ljiljana
L
Savović
Slobodan
S
Canji
Karol
K
D000328:Adult; D002220:Carbamazepine / Q000494:pharmacology*; D004584:Electronystagmography; D005133:Eye Movements / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009760:Nystagmus, Physiologic / Q000187:drug effects; D011698:Pursuit, Smooth / Q000187:drug effects; D012399:Rotation; D014724:Vestibular Function Tests
D002220:Carbamazepine