title: Identification of an intronic TG repeat polymorphism in the human proteasome core particle PROS-27K gene.
abstract: A TG dinucleotide repeat was identified in intron 6 of the human proteasome core particle PROS-27K (IOTA, PSMA6) gene. We present data on the length polymorphism of this repeat in 120 individuals from Latvia and 197 individuals from Finland. A combination of PCR and fluorescent gel electrophoresis was utilized to type the polymorphism. Twelve alleles were observed, varying in length from 10 to 23 TG repeats. Similar allele frequencies were observed in Latvian and Finnish subjects, with 17 and 20 repeats being the most frequent in both populations. We suggest that this TG dinucleotide repeat could be utilized as a prospective marker for genetic linkage and association studies of common diseases.
authors.affiliation: Institute of Biology of Latvian University, Miera Street 3, Salaspils LV2169, Latvia. tanja@email.lubi.edu.lv
authors.forename: Tatjana
authors.initials: T
authors.lastname: Sjakste
authors.forename: Lasma
authors.initials: L
authors.lastname: Lauberte
authors.forename: Yrjö
authors.initials: Y
authors.lastname: Collan
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Savontaus
authors.forename: Alla
authors.initials: A
authors.lastname: Bajare
authors.forename: Klaus
authors.initials: K
authors.lastname: Scherrer
authors.forename: Nikolajs
authors.initials: N
authors.lastname: Sjakste
mesh_terms: D003546:Cysteine Endopeptidases / Q000235:genetics*; D018900:Dinucleotide Repeats; D006579:Heterozygote; D006801:Humans; D007438:Introns; D009097:Multienzyme Complexes / Q000235:genetics*; D011110:Polymorphism, Genetic; D046988:Proteasome Endopeptidase Complex; D017422:Sequence Analysis, DNA
chemical_list: D009097:Multienzyme Complexes; D003546:Cysteine Endopeptidases; C465641:PSMA6 protein, human; D046988:Proteasome Endopeptidase Complex