Large-scale gene-expression studies and the challenge of multiple sclerosis.
In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.
Baranzini
Sergio E
SE
Department of Neurology, University of California San Francisco, San Francisco, CA 94143-0435, USA. sebaran@cgl.ucsf.edu
Hauser
Stephen L
SL
D020869:Gene Expression Profiling / Q000379:methods / Q000592:standards; D005786:Gene Expression Regulation / Q000235:genetics*; D015723:Gene Library; D006801:Humans; D008137:Longitudinal Studies; D009103:Multiple Sclerosis / Q000235:genetics* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods / Q000592:standards