title: Diagnostic localization of extra-adrenal pheochromocytoma: comparison of (123)I-MIBG imaging and (131)I-MIBG imaging.
abstract: The accurate diagnostic localization of extra-adrenal pheochromocytoma is important in the treatment of primary and metastatic tumors. In this study, we report on a case of extra-adrenal pheochromocytoma in which the tumor could not be diagnosed by 131I-metaiodobenzylguanidine (MIBG) scintigraphy but only by 123I-MIBG scintigraphy. Our patient was a 16-year old girl whose chief complaint was headaches. High levels of catecholamines were detected in the blood and urine samples. 131I-MIBG scintigraphy could not detect any abnormal accumulation, but an accumulation of 123I-MIBG was found in the pelvis. Magnetic resonance imaging (MRI) revealed a broad-based bladder tumor at the site of the accumulation. Partial cystectomy was performed, and immunohistochemical staining examination confirmed the diagnosis of extra-adrenal pheochromocytoma in the urinary bladder. In this report, we compare 131I-MIBG scintigraphy with 123I-MIBG scintigraphy and discuss their characteristics.
authors.affiliation: Department of Urology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan. nakatani@msic.med.osaka-cu.ac.jp
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Takuma
authors.initials: T
authors.lastname: Hayama
authors.forename: Junji
authors.initials: J
authors.lastname: Uchida
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sugimura
mesh_terms: D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging*; D015415:Biomarkers / Q000032:analysis; D004298:Dopamine / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D009638:Norepinephrine / Q000097:blood; D010673:Pheochromocytoma / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D015415:Biomarkers; D007457:Iodine Radioisotopes; D019797:3-Iodobenzylguanidine; D004298:Dopamine; D009638:Norepinephrine