Does nifedipine prevent the tachysystole associated with misoprostol induction?
OBJECTIVE
To determine the efficacy of oral nifedipine as prophylaxis against uterine tachysystole associated with misoprostol induction of labor.


METHODS
A total of 116 patients undergoing induction with term, singleton pregnancies were enrolled. All patients received 50 microg misoprostol intravaginally every 4 h. Patients were randomly assigned also to receive nifedipine 10 mg orally every 4 h, or no prophylaxis. The primary outcome variable was the incidence of 12 or more contractions in any 20-min interval.


RESULTS
Data on 106 patients were available for analysis. There were 55 subjects in the misoprostol-nifedipine group and 51 controls. Nifedipine did not diminish the incidence of tachysystole when added to misoprostol (42% vs. 45% without nifedipine; p = 0.7).


CONCLUSIONS
Prophylactic oral nifedipine was not shown to decrease the uterine tachysystole associated with vaginal misoprostol induction at a 50-microg dose.
Chao
A
A
El-Sayed
Y Y
YY
Sapugay
A M V
AM
D000282:Administration, Intravaginal; D000284:Administration, Oral; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000009:adverse effects*; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects*; D009543:Nifedipine / Q000008:administration & dosage*; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D015149:Tocolytic Agents / Q000008:administration & dosage*; D014590:Uterine Contraction / Q000187:drug effects*; D014591:Uterine Diseases / Q000209:etiology / Q000517:prevention & control*; D014599:Uterus / Q000187:drug effects
D010120:Oxytocics; D015149:Tocolytic Agents; D016595:Misoprostol; D009543:Nifedipine