title: Extensive squamous metaplasia with cytologic atypia in diffuse alveolar damage mimicking squamous cell carcinoma: a report of 2 cases.
abstract: Squamous metaplasia in the setting of diffuse alveolar damage, a form of acute lung injury, in rare cases can be very extensive with cytologic atypia, mimicking squamous cell carcinoma. We describe 2 such cases that posed diagnostic difficulty in the evaluation of biopsy specimens. These cases demonstrate that histologic findings must be correlated with clinical and radiologic information to avoid a misdiagnosis of malignancy.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Shuji
authors.initials: S
authors.lastname: Ogino
authors.forename: Teri J
authors.initials: TJ
authors.lastname: Franks
authors.forename: Mona
authors.initials: M
authors.lastname: Yong
authors.forename: Michael N
authors.initials: MN
authors.lastname: Koss
mesh_terms: D000293:Adolescent; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008679:Metaplasia; D018307:Neoplasms, Squamous Cell / Q000473:pathology*