[Clone of M2 autoantigens from human sources and evaluation of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis].
OBJECTIVE
To evaluate the value of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis (PBS).


METHODS
M2 autoantibodies were detected by ELISA combined with western-blot.


RESULTS
Thirty-two cases presented positive M2 autoantibodies, including 20 cases of PBC, 9 liver diseases of unknown etiology, 1 autoimmune hepatitis and 1 drug-induced liver injury.


CONCLUSIONS
M2 autoantibodies show good sensitivity and specificity to diagnosis of PBC. It should be used as a powerful and specific maker for the diagnosis of PBC
Jiang
Xiaohua
X
Clinical Immunology Center of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Zhong
Renqian
R
Tu
Xiaoqing
X
Li
Wenwen
W
Kong
Xiantao
X
D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D056486:Chemical and Drug Induced Liver Injury; D004797:Enzyme-Linked Immunosorbent Assay; D019693:Hepatitis, Autoimmune; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D001324:Autoantigens