title: Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene.
abstract: We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.
authors.affiliation: Department of Psychiatry, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA.
authors.forename: Niall P
authors.initials: NP
authors.lastname: Murphy
authors.forename: Hoa A
authors.initials: HA
authors.lastname: Lam
authors.forename: Zhenping
authors.initials: Z
authors.lastname: Chen
authors.forename: John E
authors.initials: JE
authors.lastname: Pintar
authors.forename: Nigel T
authors.initials: NT
authors.lastname: Maidment
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D003932:Heroin / Q000494:pharmacology*; D008032:Limbic System / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects; D018847:Opioid Peptides / Q000502:physiology; D011957:Receptors, Opioid / Q000235:genetics*; D000094942:Nociceptin Receptor; D000097629:Nociceptin
chemical_list: D000701:Analgesics, Opioid; D004298:Dopamine; D003932:Heroin; D018847:Opioid Peptides; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; D000097629:Nociceptin; C000722287:Oprl1 protein, mouse