The mammalian endoplasmic reticulum as a sensor for cellular stress.
The recent elucidation of the mammalian unfolded protein response pathway has revealed a unique and transcriptionally complex signal transduction pathway that protects cells from a variety of physical and biochemical stresses that can occur during normal development and in disease states. Although the stress conditions are monitored in the endoplasmic reticulum, the beneficial effects of this pathway are extended to other cellular organelles and to the organism itself.
Ma
Yanjun
Y
Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hendershot
Linda M
LM
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000502:physiology*; D004781:Environmental Exposure; D051379:Mice; D018832:Molecular Chaperones / Q000737:chemistry / Q000502:physiology*; D017510:Protein Folding; D015398:Signal Transduction / Q000502:physiology*; D013314:Stress, Mechanical
D018832:Molecular Chaperones