title: Direct synthesis of guanidines using di(imidazole-1-yl)methanimine.
abstract: A direct synthetic approach to guanidine compounds is reported here using di(imidazole-1-yl)methanimine and di(imidazole-1-yl)cyanomethanimine as guanylating reagents.
authors.affiliation: Department of Research, Guilford Pharmaceuticals, Inc., Baltimore, Maryland 21224, USA. wuy@guilfordpharm.com
authors.forename: Yong-Qian
authors.initials: YQ
authors.lastname: Wu
authors.forename: Sean K
authors.initials: SK
authors.lastname: Hamilton
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Wilkinson
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Hamilton
mesh_terms: D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008744:Methylamines; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D006146:Guanidines; D007093:Imidazoles; D007202:Indicators and Reagents; D008744:Methylamines