title: Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia.
abstract: By limiting filling, abnormalities of right ventricular (RV) diastolic function may impair systolic function and affect adaptation to disease. To quantify diastolic RV pressure-volume relations and myocardial compliance (MC), a new sigmoidal model was developed. RV micromanometric and sonomicrometric data in alert dogs at control (n = 16) and under surgically induced subacute (2-5 wk) RV pressure overload (n = 6), volume overload (n = 7), and ischemia (n = 6) were analyzed. The conventional exponential model detected no changes from control in the passive filling pressure-volume (P(pf)-V) relations. The new sigmoidal model revealed significant quantifiable changes in P(pf)-V relations. Maximum RV MC (MC(max)), attained during early filling, is reduced from control in pressure overload (P = 0.0016), whereas filling pressure at maximum MC (P(MCmax)) is increased (P = 0.0001). End-diastolic RV MC increases significantly in volume overload (P = 0.0131), whereas end-diastolic pressure is unchanged. In ischemia, MC(max) is decreased (P = 0.0102), with no change in P(MCmax). We conclude that the sigmoidal model quantifies important changes in RV diastolic function in alert dog models of pressure overload, volume overload, and ischemia.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Ares
authors.initials: A
authors.lastname: Pasipoularides
authors.forename: Ming
authors.initials: M
authors.lastname: Shu
authors.forename: Ashish
authors.initials: A
authors.lastname: Shah
authors.forename: Scott
authors.initials: S
authors.lastname: Silvestry
authors.forename: Donald D
authors.initials: DD
authors.lastname: Glower
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003187:Compliance; D003971:Diastole / Q000502:physiology*; D004195:Disease Models, Animal; D004285:Dogs; D006333:Heart Failure / Q000503:physiopathology*; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*; D016278:Ventricular Function, Right / Q000502:physiology*; D017725:Ventricular Pressure / Q000502:physiology