An investigation of orotic acid levels in the breastmilk of smoking and non-smoking mothers.
OBJECTIVE
In this study; orotic acid levels in the milk of smoking and non-smoking mothers were investigated by high-performance liquid chromatography (HPLC).


RESULTS
It was found that the amount of orotic acid in the milk of smoking mothers (3.92+/-0.20 micro g/ml) was higher than that of non-smoking mothers (1.66+/-0.15 micro g/ml). Orotic acids levels in the milk of smoking mothers in comparison with non-smokers were found to be statistically significant (P<0.005).


CONCLUSIONS
Smoking may have increased the orotic acid levels by affecting pyrimidine biosynthesis pathway.
Karatas
F
F
Department of Chemistry, Firat University, Elazig 23119, Turkey. fkaratas1@hotmail.com
D000328:Adult; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry*; D009963:Orotic Acid / Q000032:analysis*; D011743:Pyrimidines / Q000096:biosynthesis; D012907:Smoking; D014542:Uridine Monophosphate / Q000378:metabolism
D011743:Pyrimidines; D009963:Orotic Acid; D014542:Uridine Monophosphate; C030986:pyrimidine