title: [Effect oh millimeter waves on the immune system in mice with experimental tumors].
abstract: The effect of low-level millimeter fractionated radiation on the production of tumor necrosis factor, intreleukin-2, interleukine-3, and nitric oxide and on the activity of natural killer cells and proliferation of T and B lymphocytes in mice was studied. Cell activity was measured in four groups of male Balb/c mice (control, exposed, tumor-bearing unexposed, and exposed tumor-bearing animals) within 30 days of tumoral growth and microwave exposure (42.2 GHz, 10 Hz amplitude modulation, 0.5 microW/cm2, 1.5 h daily). A significant increase in the production of tumor necrosis factor and nitric oxide and in the activity of natural killer cells was observed at the early stage of tumor development; this effect was considered as adaptive response. In healthy mice, millimeter radiation produced both stimulating and immunodepressive effects. The changes were nonmonotonous; as the exposure duration was increased, the stimulating effect became weaker and on day 30 it was not observed. Irradiation of tumor-bearing mice did not induce any significant changes in the activity of cells compared to unirradiated tumor-bearing animals. Moreover, exposure to millimeter waves impaired some characteristics of cell immunity in tumor-bearing mice. It was concluded that low-intensity millimeter waves do not increase the resistance against tumor as it was shown earlier in our experiments with centimeter waves.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Novoselova
authors.forename: V B
authors.initials: VB
authors.lastname: Ogaĭ
authors.forename: O A
authors.initials: OA
authors.lastname: Sinotova
authors.forename: O V
authors.initials: OV
authors.lastname: Glushkova
authors.forename: O V
authors.initials: OV
authors.lastname: Sorokina
authors.forename: E E
authors.initials: EE
authors.lastname: Fesenko
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology / Q000528:radiation effects; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology* / Q000473:pathology; D002455:Cell Division / Q000528:radiation effects; D004574:Electromagnetic Fields; D007111:Immunity, Cellular / Q000528:radiation effects; D007376:Interleukin-2 / Q000096:biosynthesis; D007377:Interleukin-3 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000528:radiation effects; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009569:Nitric Oxide / Q000096:biosynthesis; D013154:Spleen / Q000473:pathology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D007376:Interleukin-2; D007377:Interleukin-3; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide