title: QT interval and QT dispersion increase in the elderly during laparoscopic cholecystectomy: a preliminary study.
abstract: OBJECTIVE
  To compare the influence of a longer duration of intraperitoneal CO2 insufflation with head-up tilt on electrocardiogram indices during laparoscopic cholecystectomy between elderly and younger patients.
  
  
  METHODS
  Twelve elderly and 12 younger patients were studied. In all patients, intraperitoneal CO2 insufflation was performed for more than 150 min in the head-up position. RR interval, QT interval, the rate-corrected QT (QTc) interval, QT dispersion (QTD) and the rate-corrected QTD (QTcD) were measured.
  
  
  RESULTS
  The QT interval and the QTc interval increased significantly from 120 to 150 min after CO2 insufflation in the elderly. The QTD and QTcD increased significantly during CO2 insufflation in both groups. Those were significantly greater in the elderly than in younger patients from 120 to 150 min after CO2 insufflation.
  
  
  CONCLUSIONS
  Longer duration of CO2 insufflation with head-up tilt is associated with a prolongation of the QT interval and the QTD in elderly patients. The clinical significance of these findings remains to be determined.
authors.affiliation: Department of Anesthesiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. egawa718@maple.ocn.ne.jp
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Egawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Minami
authors.forename: Kouichi
authors.initials: K
authors.lastname: Fujii
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hamaguchi
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Okuda
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000494:pharmacology; D017081:Cholecystectomy, Laparoscopic; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007327:Insufflation; D008297:Male; D008875:Middle Aged
chemical_list: D002245:Carbon Dioxide