title: Spirostanol pentaglycosides from the underground parts of polianthestuberosa.
abstract: Phytochemical analysis of the underground parts of Polianthes tuberosa has resulted in the isolation of four new spirostanol saponins with five monosaccharides (1-4). Their structures were determined by spectroscopic analysis, including extensive 1D and 2D NMR data, and the results of hydrolytic cleavage. The cytotoxic activities of 1-4 against HL-60 human promyelocytic leukemia cells and HSC-2 human oral squamous cell carcinoma cells are reported.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Japan. mimakiy@ps.toyaku.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
authors.forename: Akihito
authors.initials: A
authors.lastname: Yokosuka
authors.forename: Chiseko
authors.initials: C
authors.lastname: Sakuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sashida
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000070357:Asparagaceae / Q000737:chemistry*; D002240:Carbohydrate Sequence; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D012503:Saponins