Long-term neuropsychological effects and MRI findings in patients with CS2 poisoning.
OBJECTIVE
To evaluate the long-term neuropsychological effects and magnetic resonance imaging (MRI) findings among retired patients with a history of exposure to carbon disulfide (CS2).


METHODS
Seventy-four patients with a history of exposure to CS2 were divided into two equal groups according to their level of exposure, and they completed a questionnaire and were evaluated for neuropsychological symptoms using the Korean version of the revised Wechsler Adult Intelligence Scale. Thirty-one MRI images were reviewed retrospectively.


RESULTS
There were no statistically significant differences in total, verbal and performance IQs between high- and low-exposure groups. MRI findings revealed a significantly larger number of cerebral lacunae (five of 12 subjects) in the high-exposure group. Periventricular hyperintensities were mostly located in frontal and occipital areas, and white-matter hyperintensities were mostly in frontal and parietal areas.


CONCLUSIONS
The higher prevalence of lacunae in the high-exposure group as revealed by MRI suggests that further MRI studies are needed into long-term neuropsychological effects induced by CS2.
Cho
S K
SK
Department of Psychiatry, Eumsung Mental Hospital, Chung-Buk, South Korea. t8780697@yahoo.co.kr
Kim
R H
RH
Yim
S H
SH
Tak
S W
SW
Lee
Y K
YK
Son
M A
MA
D000368:Aged; D001526:Behavioral Symptoms / Q000139:chemically induced* / Q000473:pathology*; D020520:Brain Infarction / Q000139:chemically induced / Q000473:pathology; D002246:Carbon Disulfide / Q000008:administration & dosage / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors
D002246:Carbon Disulfide