Prodrug and covalent linker strategies for the solubilization of dual-action antioxidants/iron chelators.
Water soluble prodrugs of hybrid free radical scavenger/iron chelating molecules, based on 3,5-disubstituted-4-hydroxyphenyl derivatives and 3-hydroxy-2-methyl-4(1H)-pyridinone (deferiprone), have been prepared. Related hybrid molecules containing a covalent poly(ethylene)glycol or an amine linker were also synthesized.
Bebbington
David
D
Department of Chemistry, Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, UK.
Dawson
Claire E
CE
Gaur
Suneel
S
Spencer
John
J
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D002084:Butylated Hydroxytoluene / Q000737:chemistry; D003432:Cross-Linking Reagents; D000077543:Deferiprone; D006868:Hydrolysis; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D010949:Plasma / Q000737:chemistry; D011092:Polyethylene Glycols; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011728:Pyridones / Q000737:chemistry; D051381:Rats; D012995:Solubility; D013329:Structure-Activity Relationship
D000975:Antioxidants; D003432:Cross-Linking Reagents; D007502:Iron Chelating Agents; D011355:Prodrugs; D011728:Pyridones; D002084:Butylated Hydroxytoluene; D000077543:Deferiprone; D011092:Polyethylene Glycols