[Embryogenesis and early postnatal ontogenesis of posterity of two generations of female Wistar rats, depending on the time of their fertilization after low dose radiation exposure].
On the first day and 3-10 or 40-60 days after a single whole-body gamma-irradiation with doses of 0.25, 0.5 and 1 Gy, the pubertal female Wistar rats coupled with intact males. The embryogenesis and early postnatal ontogenesis of posterity of two generations from these parents were investigated. A raised mutation rate and physiological inferiority of the progeny was found, depending both on a dose and on the degree of oocyte maturity at the moment of the irradiation. The obtained data showed the instability of the irradiated genome in a number of generations.
Palyga
G F
GF
Medical Radiological Scientific Center, Russian Academy of Medical Sciences, Obninsk, 24903 Russia. palyga@yandex.ru
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D004307:Dose-Response Relationship, Radiation; D005314:Embryonic and Fetal Development / Q000528:radiation effects*; D005260:Female; D005298:Fertility / Q000528:radiation effects*; D005306:Fertilization; D008297:Male; D009154:Mutation; D051381:Rats; D017208:Rats, Wistar; D014916:Whole-Body Irradiation