Bilateral presumed endogenous candida endophthalmitis and stage 3 retinopathy of prematurity.
OBJECTIVE
To report a case of presumed endogenous bilateral Candida endophthalmitis that developed in an infant with bilateral posterior stage 3 retinopathy of prematurity.


METHODS
Interventional case report.


METHODS
In a very low birth weight and extremely premature infant, presumed endogenous bilateral Candida endophthalmitis was successfully eradicated from each eye and retinopathy of prematurity was managed.


RESULTS
Candida endophthalmitis was successfully eradicated from each eye by vitrectomy with instillation of 5 microg amphotericin B. Stage 3 retinopathy of prematurity without "plus disease" in the right eye regressed without ablation of the avascular peripheral retina. Stage 3 retinopathy with "plus disease" in the left eye was successfully managed with endolaser photocoagulation.


CONCLUSIONS
Concomitant Candida endophthalmitis and posterior stage 3 retinopathy of prematurity often portend a dismal prognosis. We describe an infant for whom prompt diagnosis and aggressive therapy of both conditions resulted in a favorable anatomic outcome in both eyes.
Gago
Luis C
LC
Beaumont Eye Institute, William Beaumont Hospital, Royal Oak, Michigan, USA.
Capone
Antonio
A
Trese
Michael T
MT
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000628:therapy; D009877:Endophthalmitis / Q000150:complications* / Q000382:microbiology*; D005654:Fundus Oculi; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D012178:Retinopathy of Prematurity / Q000150:complications* / Q000473:pathology; D016896:Treatment Outcome; D014821:Vitrectomy
D000935:Antifungal Agents; D000666:Amphotericin B