title: Intracranial pressure and cerebral blood flow velocity in preterm infants with posthaemorrhagic ventricular dilatation.
abstract: OBJECTIVE
  To determine the volume of cerebrospinal fluid (CSF) that should be tapped in preterm infants with posthaemorrhagic ventricular dilatation as guided by intracranial pressure (ICP) and cerebral blood flow velocity (CBFV).
  
  
  METHODS
  The total number of measurements was 106 in 22 infants. Birth weights ranged from 630 to 2050 g, gestational age from 24.5 to 30.3 weeks, and age at insertion from 12 to 67 days. A subcutaneous ventricular catheter reservoir for repetitive CSF drainage was placed when the diameter of a ventricle was > 4 mm above the 97th centile. A volume of 5 ml/kg body weight was removed twice daily. ICP and CBFV were determined before and after CSF tapping.
  
  
  RESULTS
  If the ICP after tapping exceeded 7 cm H(2)O, tapping did not result in a significant improvement in CBFV. If the ICP before tapping was less than 6 cm H(2)O, tapping also had no effect on CBFV. Longitudinal studies in individual infants showed a slight correlation between ICP and CBFV.
  
  
  CONCLUSIONS
  Volume of repetitive CSF drainage in preterm infants with posthaemorrhagic ventricular dilatation guided by ICP and CBFV may be a useful technique. An ICP of about 6 cm H(2)O is the cut off point for CSF drainage.
authors.affiliation: Department of Neonatology, University Hospital Maastricht, The Netherlands. wma@skin.azm.nl
authors.forename: W J
authors.initials: WJ
authors.lastname: Maertzdorf
authors.forename: J S H
authors.initials: JS
authors.lastname: Vles
authors.forename: E
authors.initials: E
authors.lastname: Beuls
authors.forename: A L M
authors.initials: AL
authors.lastname: Mulder
authors.forename: C E
authors.initials: CE
authors.lastname: Blanco
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000503:physiopathology* / Q000628:therapy; D002557:Cerebrospinal Fluid Shunts; D004108:Dilatation, Pathologic / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000503:physiopathology* / Q000628:therapy; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male