title: Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity.
abstract: Thirty-eight of 295 subjects participating in a randomized, double-blind, placebo-controlled trial of the efficacy of daily administration of atovaquone/proguanil for malaria prevention developed malaria at some time during the 20-week prophylaxis period. These subjects (3 atovaquone/proguanil recipients and 35 placebo recipients) were treated with 4 tablets of atovaquone/proguanil per day for 3 days. Atovaquone/proguanil provided safe, well-tolerated, and effective therapy for uncomplicated malaria in nonimmune Indonesians.
authors.affiliation: Parasitic Diseases Program, US Naval Medical Research Unit 2, Jakarta, Indonesia.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Lacy
authors.forename: Jason D
authors.initials: JD
authors.lastname: Maguire
authors.forename: Mazie J
authors.initials: MJ
authors.lastname: Barcus
authors.forename: Judith
authors.initials: J
authors.lastname: Ling
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bangs
authors.forename: Robert
authors.initials: R
authors.lastname: Gramzinski
authors.forename: Hasan
authors.initials: H
authors.lastname: Basri
authors.forename: Priyanto
authors.initials: P
authors.lastname: Sismadi
authors.forename: Gerri B
authors.initials: GB
authors.lastname: Miller
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Chulay
authors.forename: David J
authors.initials: DJ
authors.lastname: Fryauff
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Hoffman
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Baird
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D053626:Atovaquone; D004311:Double-Blind Method; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000276:immunology; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009285:Naphthoquinones / Q000627:therapeutic use*; D010963:Plasmodium falciparum / Q000187:drug effects; D010966:Plasmodium vivax / Q000187:drug effects; D002727:Proguanil / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D009285:Naphthoquinones; D002727:Proguanil; D053626:Atovaquone