title: Malignant tumor disease as a sub-chronic, progressive intoxication on the basis of the perpetuation of the release of amino acids, initiated by a retrograde-differentiated muscle degradation protease.
abstract: The proliferation of malignant tumor cells in the tissue of origin, as well as their invasion and survival in other tissues, is based on a pathogenicity mechanism, which, via the perpetuation of the release of amino acids, leads to a toxic, progressively acting impairment of normal cell functions. Consequently, a malignant tumor disease can be considered as a progressive intoxication exhibiting a sub-chronic course. The initialization is effected by means of a protease which, when related to the evolution scale of proteases, had experienced a downgrading. This corresponds to the degree of differentiation of the malignant tumor cells. As a faulty protein, it cannot, or at least not effectively, be degraded by the host organism. The aim of this faulty protein is the degradation of the proteins of the skeletal muscles. The amino acid lysine seems to be of particular importance for the synthesis of the retrograde-differentiated muscle degradation protease (RMDP), since the reduction of the availability of lysine exhibits a correlation with an anti-tumor effect.
authors.affiliation: drdouvlis@AOL.com
authors.forename: Z
authors.initials: Z
authors.lastname: Douvlis
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D018450:Disease Progression; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000172:deficiency; D008954:Models, Biological; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000201:enzymology*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000628:therapy; D009748:Nutrition Disorders / Q000378:metabolism
chemical_list: D000596:Amino Acids; D009124:Muscle Proteins; D009363:Neoplasm Proteins; D010450:Endopeptidases; D008239:Lysine