Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion.
Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.
Yang
J
J
School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089, USA.
Klaidman
L K
LK
Adams
J D
JD
D000818:Animals; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D017241:MELAS Syndrome / Q000188:drug therapy; D009243:NAD / Q000378:metabolism; D009536:Niacinamide / Q000737:chemistry* / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D015427:Reperfusion Injury / Q000188:drug therapy*
D009243:NAD; D009536:Niacinamide; D011065:Poly(ADP-ribose) Polymerases