[Association between aldosterone synthase gene polymorphism and hypertrophic cardiomyopathy].
OBJECTIVE
To investigate the relationship between aldosterone synthase (CYP11B2) gene polymorphism and hypertrophic cardiomyopathy (HCM).


METHODS
Fifteen HCM patients and 18 healthy subjects were enrolled in this study. Peripheral blood samples were collected from these subjects to exact genome DNA. PCR and Hae III restriction endonuclease digestion were employed to study -344C/T polymorphism of CYP11B2 gene.


RESULTS
CYP11B2 gene showed a significant difference in CT genotype distribution in HCM groups as compared with that in the control groups (P<0.05).


CONCLUSIONS
CT genotype of CYP11B2 gene may be one of factors responsible for the pathogenesis of HCM in a proportion of patients.
Chen
Ai-Hua
AH
Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. chenaha@21.cn.com
Zhang
Wen-Xiu
WX
Li
Zhi-Liang
ZL
Tang
Xiao-Ming
XM
Lu
Qing
Q
Qian
Xue-Xian
XX
Li
Liu-Yang
LY
Sun
Jia-Zhen
JZ
D002312:Cardiomyopathy, Hypertrophic / Q000201:enzymology / Q000235:genetics*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D019405:Cytochrome P-450 CYP11B2