A dinitrogenous alkaloid from Cyrtanthus obliquus.
The ethanolic extract of bulbs of Cyrtanthus obliquus (L.f.) Ait yielded the new dinitrogenous alkaloid obliquine (1), 3S, 4aS, 11S, 10bS-3,4,4a,13,11,5,6-heptahydro-5[2-(4-hydroxyphenyl)ethyl]-3-methoxy-13-methyl-[1,3-dioxolo[4,5-g]indolo[3,3a-c]-isoquinolin-12-one, together with the five known structures 11alpha-hydroxygalanthamine, 3-epimacronine, narcissidine, tazettine and trisphaeridine. All structures were established using 1D and 2D NMR techniques and HREIMS. The alkaloids were tested for cytotoxicity against two mammalian cell lines and did not show activity at concentrations up to 100 microg/ml.
Brine
Natalie D
ND
Pharmacology Division, Department of Medicine, University of Cape Town, Observatory 7925, South Africa.
Campbell
William E
WE
Bastida
Jaume
J
Herrera
Maria R
MR
Viladomat
Francesc
F
Codina
Carles
C
Smith
Peter J
PJ
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000633:toxicity; D047151:Amaryllidaceae Alkaloids; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D007546:Isoquinolines; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D007546:Isoquinolines; C473532:obliquine