title: A series of C-terminal amino alcohol dipeptide A beta inhibitors.
abstract: Potent, small molecule A beta inhibitors have been prepared that incorporate an alanine core bracketed by an N-terminal arylacetyl group and various C-terminal amino alcohols. The compounds exhibit stereospecific inhibition as demonstrated in an in vitro assay.
authors.affiliation: Elan, 800 Gateway Blvd, South San Francisco, CA 94080, USA. al.garofalo@elan.com
authors.forename: Albert W
authors.initials: AW
authors.lastname: Garofalo
authors.forename: David W G
authors.initials: DW
authors.lastname: Wone
authors.forename: Angela
authors.initials: A
authors.lastname: Phuc
authors.forename: James E
authors.initials: JE
authors.lastname: Audia
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Bales
authors.forename: Harry F
authors.initials: HF
authors.lastname: Dovey
authors.forename: Darren B
authors.initials: DB
authors.lastname: Dressen
authors.forename: Beverly
authors.initials: B
authors.lastname: Folmer
authors.forename: Erich G
authors.initials: EG
authors.lastname: Goldbach
authors.forename: Ashley C
authors.initials: AC
authors.lastname: Guinn
authors.forename: Lee H
authors.initials: LH
authors.lastname: Latimer
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Mabry
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Nissen
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pleiss
authors.forename: Stephen
authors.initials: S
authors.lastname: Sohn
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Thorsett
authors.forename: Jay S
authors.initials: JS
authors.lastname: Tung
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000494:pharmacology*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000235:genetics; D016282:Aspartic Acid Endopeptidases; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D009154:Mutation; D013329:Structure-Activity Relationship; D014162:Transfection
chemical_list: D000605:Amino Alcohols; D016229:Amyloid beta-Peptides; D004151:Dipeptides; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human