title: Endoreduplication of the hyperhaploid maternal complement and abnormal pronuclear formation in a human zygote obtained after intracytoplasmic sperm injection.
abstract: We report the cytogenetic analysis of a tripronuclear zygote with two polar bodies observed after intracytoplasmic sperm injection. Rare previous investigations of this kind of zygote suggested a diploid or a hypotriploid chromosome constitution. In contrast, the present case turned out to be hypertriploid. Besides the haploid (23,Y) sperm chromosome set, there was a hyperdiploid endoreduplicated (end48,XX,+18,+18) maternal contribution. This zygote not only revealed a peculiar combination of different anomalies (hyperhaploidy of the female gamete, endoreduplication and abnormal pronuclear formation) but also indicates that endoreduplication may sporadically contribute to the generation of triploidy.
authors.affiliation: Department of Gynecology and Obstetrics, Centre of Reproductive Medicine, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany. bernd.rosenbusch@medizin.uni-ulm.de
authors.forename: Bernd
authors.initials: B
authors.lastname: Rosenbusch
authors.forename: Birgitta
authors.initials: B
authors.lastname: Glaeser
authors.forename: Cosima
authors.initials: C
authors.lastname: Brucker
authors.forename: Michael
authors.initials: M
authors.lastname: Schneider
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D015053:Zygote / Q000473:pathology* / Q000502:physiology*