Effects of acupuncture on the 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats.
In the present study, the effects of acupuncture on the endurance treadmill exercise, serotonin (5-hydroxytryptamine, 5-HT) synthesis, and tryptophan hydroxylase (TPH) expression in the dorsal raphe nuclei were investigated. Acupunctural stimulation were bilaterally inserted into the locus of Zusanli in each hind leg for 20 min. Onset of exhaustion time on the treadmill running was increased significantly by acupunctural stimulation and exercise-induced increments of the 5-HT synthesis and TPH expression in the dorsal raphe were suppressed by acupunctural stimulation. Based on the results, it can be suggested that the suppressive effects of acupunctural stimulation on the 5-HT synthesis and TPH expression in the dorsal raphe during exercise is one of ergogenic mechanisms of acupuncture.
Lee
Sang-Hak
SH
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
Chung
Seok-Hee
SH
Lee
Jong-Soo
JS
Kim
Sung-Soo
SS
Shin
Hyun-Dae
HD
Lim
Baek-Vin
BV
Jang
Mi-Hyeon
MH
Kim
Hong
H
Kim
Ee-Hwa
EH
Kim
Chang-Ju
CJ
D015670:Acupuncture Therapy / Q000379:methods; D000818:Animals; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D011903:Raphe Nuclei / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000096:biosynthesis*; D014365:Tryptophan Hydroxylase / Q000096:biosynthesis*
D012333:RNA, Messenger; D012701:Serotonin; D014365:Tryptophan Hydroxylase