title: Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
abstract: Biaryl nitrile amines were prepared and found to have high affinity and selectivity for human and rat histamine H(3) receptors.
authors.affiliation: Neuroscience-Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6123, USA.
authors.forename: Ramin
authors.initials: R
authors.lastname: Faghih
authors.forename: Wesley
authors.initials: W
authors.lastname: Dwight
authors.forename: Anil
authors.initials: A
authors.lastname: Vasudevan
authors.forename: Jurgen
authors.initials: J
authors.lastname: Dinges
authors.forename: Scott E
authors.initials: SE
authors.lastname: Conner
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: Youssef L
authors.initials: YL
authors.lastname: Bennani
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Hancock
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000378:metabolism; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D008024:Ligands; D009570:Nitriles; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D018100:Receptors, Histamine H3