Recent advances in the development of nonpeptide somatostatin receptor ligands.
Somatostatin (SRIF) is a cyclic peptide that occurs in two biologically active forms, SRIF-14 and SRIF-28. These peptides inhibit the secretion of many other peptides, including insulin and glucagon, function as neurotransmitters or neuromodulators, and exhibit potent antiproliferative activity. Recent research has led to the development of nonpeptide SRIF ligands with high affinity and selectivity at all SRIF receptor subtypes. Additionally, the newly discovered sst(2)and sst(3) antagonists will greatly facilitate our understanding of these receptors. These novel nonpeptide SRIF agonists and antagonists may have therapeutic potential in a variety of disease states.
Crider
A Michael
AM
Department of Basic Pharmaceutical Sciences, College of Pharmacy, The University of Louisiana at Monroe, Monroe, LA 71209-0470, USA. pycrider@ulm.edu
D000818:Animals; D006801:Humans; D017481:Receptors, Somatostatin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000187:drug effects*; D013004:Somatostatin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism
D017481:Receptors, Somatostatin; C106140:somatostatin receptor sst2A; C101130:somatostatin receptor type 1; D013004:Somatostatin