Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy.
The authors evaluated epidermal nerve density (END) and thermal thresholds in 18 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). END of patients with CIDP were lower than those of controls (4.5 +/- 2.9 vs 10.5 +/- 3.9 fibers/mm, p < 0.001). Reduced END were associated with autonomic symptoms. Thermal thresholds of patients with CIDP were elevated (88.2% for warm stimuli and 70.6% for cold stimuli). Patients with CIDP have small-fiber sensory and autonomic neuropathies.
Chiang
M-C
MC
Department of Neurology, National Taiwan University Hospital, Taipei.
Lin
Y-H
YH
Pan
C-L
CL
Tseng
T-J
TJ
Lin
W-M
WM
Hsieh
S-T
ST
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003080:Cold Temperature; D004817:Epidermis / Q000294:innervation* / Q000473:pathology / Q000502:physiology; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000473:pathology / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000502:physiology; D018709:Statistics, Nonparametric