Postpartum thyroiditis.
Post partum thyroiditis occurs in 50% of TPO AB+ve women and is characterised by transient hyperthyroidism followed by transient hypothyroidism during the first six months, post partum. A third of the latter group develop permanent hypothyroidism. The syndrome is seen in 5-9% of women and post partum thyroid dysfunction (PPTD) reoccurs in 75% of women in a subsequent pregnancy. An increase in depressive symptomatology is seen in women with PPTD as well as in ante TPO Ab+ve women without PPTD. The immunology of PPT is associated with the presence of TPO antiboides with those IgG subclasses best able to activate the complement cascade. The HLA-DR frequencies seen in PPT suggest that PPT may be related to Hashimoto's thyroiditis. TPO Ab driven complement fixation is seen in PPT and complement activation relates to the extent and progression of thyroid damage. Recent studies have shown an increase in both Th2 and Th1 cytokine release from lymphocytes in ante partum women destined to develop PPTD. More data are required on the cellular immune changes both ante partum and post partum in PPT.
Lazarus
J H
JH
Lazarus@cf.ac.uk
Parkes
A B
AB
Premawardhana
L D K E
LD
D000915:Antibody Affinity; D001323:Autoantibodies / Q000032:analysis; D003167:Complement Activation; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification; D007453:Iodide Peroxidase / Q000276:immunology; D011247:Pregnancy; D011644:Puerperal Disorders / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013966:Thyroiditis / Q000276:immunology*
D001323:Autoantibodies; D006684:HLA-DR Antigens; D007074:Immunoglobulin G; D007453:Iodide Peroxidase