Increased plasma concentrations of interleukin-18 in acute coronary syndromes.
OBJECTIVE
To examine the relation between plasma concentrations of interleukin-18 (IL-18), the interferon gamma inducing factor, and clinical instability of coronary artery disease.


METHODS
Observational study in a university hospital.


METHODS
11 patients with unstable angina and negative troponin I, 21 patients with acute non-Q wave myocardial infarction (MI), 21 patients with acute Q wave MI, 9 patients with stable angina, and 11 controls.


METHODS
Plasma IL-18 concentrations and their relation to clinical instability and myocardial dysfunction.


RESULTS
Plasma concentrations of IL-18 were significantly increased in the unstable angina and MI groups in comparison with the stable angina and control groups (p < 0.01). No difference in IL-18 concentrations were found between patients with unstable angina, patients with non-Q wave MI, and patients with Q wave MI. Plasma IL-18 concentrations significantly correlated with decreased left ventricular ejection fraction (p = 0.01).


CONCLUSIONS
Plasma IL-18 concentrations are increased in patients with acute coronary syndromes and correlate with the severity of myocardial dysfunction.
Mallat
Z
Z
Institut National de la Santé et de la Recherche Médicale, INSERM U541, Hôpital Lariboisiére, 41, Bd de la Chapelle, 75475 Paris cedex 10, France. ziad.mallat@inserm.lrb.ap-hop-paris.fr
Henry
P
P
Fressonnet
R
R
Alouani
S
S
Scoazec
A
A
Beaufils
P
P
Chvatchko
Y
Y
Tedgui
A
A
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000502:physiology; D013577:Syndrome
D015415:Biomarkers; D020382:Interleukin-18