title: The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules.
abstract: Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.
authors.affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Margo H
authors.initials: MH
authors.lastname: Furman
authors.forename: Neelendu
authors.initials: N
authors.lastname: Dey
authors.forename: Domenico
authors.initials: D
authors.lastname: Tortorella
authors.forename: Hidde L
authors.initials: HL
authors.lastname: Ploegh
mesh_terms: D017951:Antigen Presentation; D002213:Capsid / Q000378:metabolism*; D036022:Capsid Proteins; D003587:Cytomegalovirus / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D014407:Tumor Cells, Cultured; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D036022:Capsid Proteins; D015395:Histocompatibility Antigens Class I; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; C109087:US10 protein, Herpes simplex virus type 1; C074546:US11 protein, herpesvirus; C118670:US2 protein, Varicellovirus; D014759:Viral Envelope Proteins; D014764:Viral Proteins