Diamine-catalyzed asymmetric Michael additions of aldehydes and ketones to nitrostyrene.
[reaction: see text] The direct Michael addition of aldehydes and ketones to nitrostyrene, catalyzed by N-i-Pr-2,2'-bipyrrolidine, is described. The desired 1,4-adducts are obtained in excellent yield with enantioselectivities up to 85% ee and dr up to 95:5 of the syn product.
Alexakis
Alexandre
A
Chimie Organique, Sciences II, University of Geneva, Quai Ernest Ansermet, CH-1211, Geneva, Switzerland. alexandre.alexakis@chiorg.unige.ch
Andrey
Olivier
O