Nematodirus battus 50 years on--a realistic vaccine candidate?
It has been 50 years since the parasitic nematode of lambs, Nematodirus battus, was first described. This parasite has several interesting features; in particular, it induces a rapid, protective immune response in infected young lambs (< 3 months of age), which is not observed if lambs are infected with other trichostrongyle nematodes. Indeed, protection against most gastrointestinal nematodes only develops once lambs are over five to six months old. In this article I suggest that N. battus offers an opportunity to improve our understanding of protective immune responses in young lambs, and could therefore hold a key to rational anti-nematode vaccine developments, based on natural antigens.
Winter
Mike D
MD
School of Biology, University of Leeds, Leeds, UK LS2 9JT. m.d.winter@leeds.ac.uk
D000367:Age Factors; D000818:Animals; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology*; D014251:Trichostrongyloidea / Q000254:growth & development / Q000276:immunology* / Q000648:ultrastructure; D014252:Trichostrongyloidiasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D006113:United Kingdom