title: Effects of acupuncture on the 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats.
abstract: In the present study, the effects of acupuncture on the endurance treadmill exercise, serotonin (5-hydroxytryptamine, 5-HT) synthesis, and tryptophan hydroxylase (TPH) expression in the dorsal raphe nuclei were investigated. Acupunctural stimulation were bilaterally inserted into the locus of Zusanli in each hind leg for 20 min. Onset of exhaustion time on the treadmill running was increased significantly by acupunctural stimulation and exercise-induced increments of the 5-HT synthesis and TPH expression in the dorsal raphe were suppressed by acupunctural stimulation. Based on the results, it can be suggested that the suppressive effects of acupunctural stimulation on the 5-HT synthesis and TPH expression in the dorsal raphe during exercise is one of ergogenic mechanisms of acupuncture.
authors.affiliation: Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Sang-Hak
authors.initials: SH
authors.lastname: Lee
authors.forename: Seok-Hee
authors.initials: SH
authors.lastname: Chung
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Hyun-Dae
authors.initials: HD
authors.lastname: Shin
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Ee-Hwa
authors.initials: EH
authors.lastname: Kim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods; D000818:Animals; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D011903:Raphe Nuclei / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000096:biosynthesis*; D014365:Tryptophan Hydroxylase / Q000096:biosynthesis*
chemical_list: D012333:RNA, Messenger; D012701:Serotonin; D014365:Tryptophan Hydroxylase