title: Outcomes in patients with Goodpasture's syndrome and hydrocarbon exposure.
abstract: Goodpasture's Syndrome has been associated with hydrocarbon exposure. No study has examined outcomes in these patients. All reported cases of Goodpasture's Syndrome and hydrocarbon exposure were identified using MEDLINE and was analyzed for factors related to outcomes. A total of 43 cases were identified since 1969. The mean age of patients was 28 years old. There was a slight predilection for males (60%) when analyzing gender. Various types of hydrocarbons were identified and the duration of exposure varied from minutes to years. A majority of patients (86%) had pulmonary hemorrhage and antiglomerular basement membrane antibodies (AGBM) (92%). Patients were treated with immunosuppressive agents. The only significant statistical correlation was female patients with hydrocarbon exposure were younger. There was no correlation between age, gender, duration of exposure, presence of pulmonary hemorrhage or AGBM, or other risk factors and outcome. The relationship between hydrocarbon exposure and Goodpasture's Syndrome remains unclear since only 6% of cases in the literature had exposure. Even though most patients survived, no factor studied affected outcome making it difficult to predict prognosis in these patients.
authors.affiliation: Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70012, USA. mrugshah@hotmail.com
authors.forename: Mrugeshkumar K
authors.initials: MK
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000139:chemically induced* / Q000628:therapy*; D005260:Female; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects*; D007223:Infant; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care
chemical_list: D006838:Hydrocarbons