title: Stage IV oral cavity carcinoma. Is conventional radical treatment an option?
abstract: OBJECTIVE
  To evaluate the outcome of radical treatment for patients with stage IV squamous cell carcinoma of the oral cavity.
  
  
  METHODS
  Using head and neck tumor database, 57 patients with stage IV non-metastatic invasive squamous cell carcinoma of the oral cavity treated with curative intent at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia, between July 1992 and June 1998, were identified and retrospectively reviewed.
  
  
  RESULTS
  Our cohort of patients consisted of 33 males and 24 females, with a median age of 65 years. The primary sites were alveolus (26), tongue (22), buccal mucosa (6), floor of mouth (2) and retromolar trigone (one). Definitive radiotherapy was used in 7 patients, surgery in 17 and combined modality in 33. With a median follow-up for surviving patients of 53-months, the actuarial 5-year overall survival and relapse free survival was 20% and 14%. Tumors arising from the alveolus showed a better outcome as compared to the rest of oral cavity sites with an overall survival and relapse free survival of 32% and 26% compared to 8% and 4% (p value=0.0057 and 0.0038).
  
  
  CONCLUSIONS
  Advanced oral cavity tumors are aggressive neoplasms with a poor outcome to conventional treatment modalities. New approaches like neoadjuvant or concurrent chemoradiotherapy with or without surgery need to be considered and evaluated in prospective studies.
authors.affiliation: Department of Radiation Oncology, King Faisal Specialist Hospital and Research Centre, MBC 34, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. nrajhi@kfshrc.edu.sa
authors.forename: Nasser
authors.initials: N
authors.lastname: Al-Rajhi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saleem
authors.forename: Abdullah S
authors.initials: AS
authors.lastname: Al-Amro
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: El-Enbaby
authors.forename: Gamal A
authors.initials: GA
authors.lastname: El-Husseiny
authors.forename: Zeyad Z
authors.initials: ZZ
authors.lastname: Mahasin
authors.forename: Kalid M
authors.initials: KM
authors.lastname: Taibah
authors.forename: Ali M
authors.initials: AM
authors.lastname: Al-Zahrani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012529:Saudi Arabia; D016896:Treatment Outcome