Morphological alterations induced by loud noise in the myocardium: the role of benzodiazepine receptors.
Noise represents an environmental stress factor affecting several organs and apparati, including the cardiovascular system. In experimental animals undergoing noise exposure, subcellular myocardial changes have been reported, especially at mitochondrial level; in particular, after 6 hours of exposure only the atrium exhibited significant mitochondrial alterations, whereas after 12 hours as well as subchronic exposure both atrium and ventricle were damaged. The first part of the present article overviews the experimental evidence on effects of noise on the myocardium. In the second part, the review analyzes the role of benzodiazepine receptors and the potential efficacy of benzodiazepine ligands in preventing the mitochondrial damage induced by noise exposure. Drugs acting at both central and peripheral benzodiazepine receptors significantly prevent this damage. Differences in the amount and the duration of the protective effect might depend on variability in the potency and pharmacokinetics of the specific drug. The effects of the combined treatment with selective and non-selective peripheral benzodiazepine ligands on noise stimulation are discussed at biochemical level reviewing studies on the effects of noise exposure on mitochondrial fractions.
Gesi
Marco
M
Department of Human Morphology and Applied Biology, School of Medicine, University of Pisa, 56126 Pisa, Italy. m.gesi@anist.med.unipi.it
Fornai
Francesco
F
Lenzi
Paola
P
Ferrucci
Michela
M
Soldani
Paola
P
Ruffoli
Riccardo
R
Paparelli
Antonio
A
D000818:Animals; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008929:Mitochondria, Heart / Q000502:physiology / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure*; D009622:Noise / Q000009:adverse effects*; D051381:Rats; D011963:Receptors, GABA-A / Q000502:physiology* / Q000648:ultrastructure
D011963:Receptors, GABA-A