title: Preliminary evaluation of Kielmeyera coriacea leaves extract on the central nervous system.
abstract: The hydroalcoholic extract of Kielmeyera coriacea leaves was evaluated for effects on the central nervous system by means of behavioral models which included forced swimming, open-field and elevated plus-maze tests. According to the results, K. coriacea leaves extract is effective as anxiolytic but not as an antidepressant drug.
authors.affiliation: Department of Pharmacy and Pharmacology, Universidade Estadual de Maringá, PR, Brazil. eaaudi@uem.br
authors.forename: E A
authors.initials: EA
authors.lastname: Audi
authors.forename: F
authors.initials: F
authors.lastname: Otobone
authors.forename: J V C
authors.initials: JV
authors.lastname: Martins
authors.forename: D A G
authors.initials: DA
authors.lastname: Cortez
mesh_terms: D000284:Administration, Oral; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D028084:Clusiaceae; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010936:Plant Extracts; D007099:Imipramine; D003975:Diazepam