BGP expression in gastric biopsies may predict the development of new lesions after local treatment for early gastric cancer.
BACKGROUND
Our previous studies have demonstrated the significant role of the generative cells of intestinal metaplasia (IM) expressing brain (fetal)-type glycogen phosphorylase (BGP) (BGP-IM) as a premalignant lesion of intestinal-type adenocarcinoma. The aims of the present study were to investigate the incidence of BGP-IM in gastric biopsy specimens and to establish BGP-IM as a predictor of the coexistence of accessory carcinoma and/or metachronous cancers before and after local treatment for early gastric carcinoma.


METHODS
We studied the incidence of BGP-IM in eight endoscopic biopsy specimens of methylene blue-positive mucosa of the stomach obtained from patients with multiple gastric carcinomas (n = 14), a single carcinoma (n = 25), and atrophic gastritis (n = 20).


RESULTS
BGP positivity was 93.3% in the multiple carcinomas and 80.0% in the single carcinomas. The incidences of BGP-IM (mean percentage +/- SD) in the stomachs with multiple carcinomas, single carcinoma, and atrophic gastritis were 83.2% +/- 22.8%, 36.5% +/- 41.3%, and 7.1% +/- 18.0%, respectively. The incidence was significantly higher in the stomachs with multiple carcinomas than in those with a single carcinoma or those with atrophic gastritis (P < 0.001).


CONCLUSIONS
It is suggested that the frequent appearance of BGP-IM reflects the high potential of carcinogenesis of intestinal-type gastric cancer, and that the involvement of BGP-IM in more than 50% of the eight biopsies may be a predictor of the coexistence of accessory and/or metachronous carcinoma before and after local treatment for early gastric carcinoma.
Shimada
Shinya
S
Second Department of Surgery, Kumamoto University School of Medicine, Honjo, Japan.
Shiomori
Kenji
K
Honmyo
Ubehiko
U
Maeno
Masanobu
M
Yagi
Yasushi
Y
Ogawa
Michio
M
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001706:Biopsy; D002277:Carcinoma / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy*; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005757:Gastritis, Atrophic / Q000453:epidemiology / Q000378:metabolism; D025002:Glycogen Phosphorylase, Brain Form / Q000096:biosynthesis*; D006801:Humans; D015994:Incidence; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011237:Predictive Value of Tests; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy*
D014408:Biomarkers, Tumor; D025002:Glycogen Phosphorylase, Brain Form