HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate.
We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with the strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival.
Chakraborty
Rana
R
University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, UK.
Gillespie
Geraldine M A
GM
Reinis
Milan
M
Rostron
Tim
T
Dong
Tao
T
Philpott
Sean
S
Burger
Harold
H
Weiser
Barbara
B
Peto
Tim
T
Rowland-Jones
Sarah L
SL
D000293:Adolescent; D000595:Amino Acid Sequence; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015693:Gene Products, nef / Q000737:chemistry / Q000235:genetics; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D016325:HIV Long Terminal Repeat / Q000235:genetics; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000276:immunology*; D008969:Molecular Sequence Data; D054311:nef Gene Products, Human Immunodeficiency Virus
D015693:Gene Products, nef; D054311:nef Gene Products, Human Immunodeficiency Virus