title: Effect of labyrinthectomy on the spike generator of vestibular neurons in the guinea pig.
abstract: In the guinea pig, in the absence of any stimulation, all the neurons of the vestibular nuclei are tonically firing. After an ipsilateral labyrinthectomy, these neurons first cease to fire but recover their previous discharge in 7 days. Here, we tested whether a modification of the spike generator, the process transforming synaptic currents into spike patterns, could be a factor underlying this restoration. For this purpose, we studied the firing rate responses of neurons of the medial vestibular nucleus in brain stem slices to intracellularly injected currents. We conclude that although labyrinthectomy induces some plastic changes in the excitability of the neurons of the medial vestibular nucleus, these changes do not underlie the restoration of activity which occurs in these neurons when they are deprived of their labyrinthine input.
authors.affiliation: Laboratoire de Neurobiologie des Réseaux Sensorimoteurs, CNRS ESA 7060, Universités Paris 5 et Paris 7, Centre Universitaire des Saints-Pères, 75270 Paris Cédex 06, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Ris
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hachemaoui
authors.forename: Emile
authors.initials: E
authors.lastname: Godaux
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000222:Adaptation, Physiological / Q000502:physiology*; D000344:Afferent Pathways / Q000293:injuries / Q000503:physiopathology / Q000601:surgery; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D003714:Denervation; D007758:Ear, Inner / Q000293:injuries* / Q000503:physiopathology* / Q000601:surgery; D004558:Electric Stimulation; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology*; D014726:Vestibular Nuclei / Q000502:physiology*