Changes in the nutritional state and immune-serological parameters of esophagectomized patients fed jejunaly with glutamine-poor and glutamine-rich nutriments.
OBJECTIVE
In our former study we investigated the effect of glutamine-rich (I) and glutamine-poor (II) jejunal diet in operated patients with acute pancreatitis. In the glutamine-rich diet group clinical benefit and fast recovery of IgG, IgM, serum proteins, retinol-binding protein, albumin could be measured. In the present study the effects of the two types of jejunal diets I and II have been compared on the basis of changes in some immune parameters of 36 patients treated with subtotal esophagectomy for malignancy.


METHODS
In randomized controlled trial data of two groups, I. patients with glutamine-rich Stresson Multi Fibre diet (23 patients) and II. patients with Nutrison Multi Fibre glutamine-poor diet (13 patients) were analyzed. Levels of serum proteins were measured by laser nephelometry, CD markers of lymphocytes by flow cytometry, phagocyte activity by chemiluminescence.


RESULTS
Level of proteins decreased on the 2nd postoperative day in both groups, then gradually increased postoperatively. In increase of level of serum protein, retinol-binding protein, prealbumin there was no difference between the two groups.


CONCLUSIONS
In patients treated with subtotal esophagectomy, the glutamine-rich enteric diet did not result in faster recovery in levels of prealbumin, retinol-binding protein, immunoglobulins and in outcome of patients than the glutamine-poor nutriment.
Hallay
J
J
Second Department of Surgery, Medical and Health Science Centre School of Medicine, University of Debrecen, Móricz Zs. Krt. 22., Debrecen H-4004, Hungary. jhallay@jaguar.dote.hu
Kovács
G
G
Kiss Sz
S
S
Farkas
M
M
Lakos
G
G
Sipka
S
S
Bodolay
E
E
Sápy
P
P
D000209:Acute-Phase Proteins / Q000378:metabolism; D000328:Adult; D000368:Aged; D004750:Enteral Nutrition; D004938:Esophageal Neoplasms / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005526:Food, Formulated; D005973:Glutamine / Q000008:administration & dosage*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D019283:Pancreatitis, Acute Necrotizing / Q000276:immunology / Q000628:therapy*; D012177:Retinol-Binding Proteins / Q000378:metabolism; D016896:Treatment Outcome
D000209:Acute-Phase Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012177:Retinol-Binding Proteins; D005973:Glutamine