Follicular dendritic cell sarcoma of the neck; a case report and literature review.
Follicular dendritic cell (FDC) sarcomas, also known as dendritic reticulum cell tumors, are uncommon neoplasms arising from antigen-presenting cells in B-lymphofollicles of nodal and extra-nodal sites. It is considered as an intermediate grade malignancy since it has significant recurrent and metastatic potential. We report a case of FDC sarcoma arising in the neck. A 56-year-old female presented with a left neck tumor. Neck dissection was performed. Microscopically, the tumor showed spindle-shaped stromal cells with large oval and polygonal nuclei. Immunohistologically, the cells were positive for CD21 and CD35, consistent with FDC sarcomas. Adjuvant chemotherapy of cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) was given. Literature review provides the current information for the diagnosis and treatment of this unusual tumor.
Nakashima
Torahiko
T
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan. nakatora@qent.med.kyushu-u.ac.jp
Kuratomi
Yuichiro
Y
Shiratsuchi
Hideki
H
Yamamoto
Hidetaka
H
Yasumatsu
Ryuji
R
Yamamoto
Tomoya
T
Komiyama
Sohtaro
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D020566:Dendritic Cells, Follicular / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D012509:Sarcoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy