A comparison of murine and human immunoproteomes of Helicobacter pylori validates the preclinical murine infection model for antigen screening.
Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter pylori immunoproteomes of infected mice with previously reported patient data reveals a high agreement in the antigens recognized, suggesting that H. pylori in vivo protein composition and recognition by the host immune system are comparable in mice and humans. Murine Helicobacter models may thus be valid to screen antigens for human vaccination.
Bumann
Dirk
D
Department of Molecular Biology, Max-Planck-Institute for Infection Biology, Berlin, Germany.
Holland
Petra
P
Siejak
Frank
F
Koesling
Jan
J
Sabarth
Nicolas
N
Lamer
Stefanie
S
Zimny-Arndt
Ursula
U
Jungblut
Peter R
PR
Meyer
Thomas F
TF
D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis* / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D020543:Proteome
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D020543:Proteome