title: New dithiolopyrrolone antibiotics from Saccharothrix sp. SA 233. I. Taxonomy, fermentation, isolation and biological activities.
abstract: Three new natural antibacterial and antifungal dithiolopyrrolone antibiotics were isolated along with the known iso-butyropyrrothine and thiolutine from the fermentation broth of an actinomycete strain which was isolated from a saharian palm grove soil collected at Adrar, south Algeria. The strain was identified as Saccharothrix sp. The three new antibiotics exhibited broad antimicrobial activity against gram-positive bacteria, yeasts and fungi in vitro.
authors.affiliation: Laboratoire de Recherche sur les Produits Bioactifs et la Valorisation de la Biomasse, Ecole Normale Supérieure de Kouba, Alger, Algérie.
authors.forename: Lynda
authors.initials: L
authors.lastname: Lamari
authors.forename: Abdelghani
authors.initials: A
authors.lastname: Zitouni
authors.forename: Hadjira
authors.initials: H
authors.lastname: Boudjella
authors.forename: Boubekeur
authors.initials: B
authors.lastname: Badji
authors.forename: Nasserdine
authors.initials: N
authors.lastname: Sabaou
authors.forename: Ahmed
authors.initials: A
authors.lastname: Lebrihi
authors.forename: Gérard
authors.initials: G
authors.lastname: Lefebvre
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Seguin
authors.forename: François
authors.initials: F
authors.lastname: Tillequin
mesh_terms: D000192:Actinomycetales / Q000737:chemistry / Q000145:classification* / Q000254:growth & development / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011760:Pyrrolidinones