Distribution of risk factors and prophylactic drug usage in Turkish patients with angiographically established coronary artery disease.
BACKGROUND
Coronary artery disease (CAD) is the leading cause of adult deaths in our country. In clinical practice, an adequate level of secondary prevention towards CAD primarily requires full recognition of the distribution of risk factors. The aim of our study was to determine the prevalence of coronary risk factors and the use of prophylactic drugs among patients who have an angiographically proven CAD in our centre, and to compare it with those of the EUROASPIRE I and II studies.


METHODS
Cross-sectional, observational study.


METHODS
Our patients comprise 617 subjects (516 male, mean age 57.2 +/- 10.8 years) who underwent an angiography between January 2000 and May 2000 for the first time and in whom significant coronary lesions were detected. Age, gender, family history of premature CAD (FH), diabetes mellitus (DM), hypertension (HT), lipid profile, smoking, body mass index, waist circumference, hip circumference and physical activity data were recorded prior to angiography. The medical treatments received by these cases at discharge from hospital were investigated. Data thus obtained were compared with the results of the EUROASPIRE I and II trials, which studied the frequency of existing risk factors and prophylactic drug use among CAD patients in European countries.


RESULTS
Hyperlipidaemia, FH, DM, HT, smoking, obesity, central obesity were found in 52, 26, 20, 41, 65, 18 and 29% of patients, respectively. The use of antiplatelets, beta-blockers, ACE inhibitors, statins and calcium antagonists were 99, 86, 40, 63 and 16%, respectively.


CONCLUSIONS
Upon comparison of the risk factors, prevalence of obesity and DM was found to be similar to the average of nine European countries among our subjects. Smoking was found to be considerably higher, whereas HT, hyperlipidaemia and family history of premature CAD were lower than the European average within our subjects. In our cases the frequency of prophylactic drug usage at discharge was higher than the European means.
Sonmez
Kenan
K
Kosuyolu Heart and Research Hospital, Department of Cardiology, Istanbul, Turkey. sonmezk@hotmail.com
Akcay
Ahmet
A
Akcakoyun
Mustafa
M
Demir
Durmus
D
Elonu
Orhan Hakan
OH
Pala
Selcuk
S
Duran
Nilüfer Eksi
NE
Gencbay
Murat
M
Degertekin
Muzaffer
M
Turan
Fikret
F
D000328:Adult; D000368:Aged; D020132:Anticipation, Genetic; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D018890:Chemoprevention; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D015981:Epidemiologic Factors; D015444:Exercise / Q000502:physiology; D005260:Female; D006401:Hematologic Agents / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D019370:Observation; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D014421:Turkey / Q000453:epidemiology
D002317:Cardiovascular Agents; D006401:Hematologic Agents