title: Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine.
abstract: The case of a patient with familial hemiplegic migraine (FHM) suffering from prolonged right sided hemiparesis and aphasia that persisted for more than 10 days is reported. The symptoms were accompanied by slowing of the magnetoencephalogram over the left hemisphere, which normalized parallel to the clinical improvement. Positron emission tomography obtained on the 6th day revealed glucose-hypometabolism (hemispheric difference > or =10%) in left hemisphere's fronto-basal cortex, caudate nucleus, and thalamus. In contrast, magnetic resonance imaging including perfusion and diffusion weighted imaging was normal and did not show significant alterations of cortical perfusion or water mobility during the episode. We hypothesize that this finding provides evidence for a primary neuronal dysfunction causing the prolonged neurological deficits in FHM.
authors.affiliation: Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany. alexander_gutschalk@med.uni-heidelberg.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Gutschalk
authors.forename: Rainer
authors.initials: R
authors.lastname: Kollmar
authors.forename: Alexander
authors.initials: A
authors.lastname: Mohr
authors.forename: Marcus
authors.initials: M
authors.lastname: Henze
authors.forename: Nicole
authors.initials: N
authors.lastname: Ille
authors.forename: Markus
authors.initials: M
authors.lastname: Schwaninger
authors.forename: Marius
authors.initials: M
authors.lastname: Hartmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Hähnel
authors.forename: Uwe
authors.initials: U
authors.lastname: Haberkorn
authors.forename: André
authors.initials: A
authors.lastname: Rupp
authors.forename: Uta
authors.initials: U
authors.lastname: Meyding-Lamade
mesh_terms: D000328:Adult; D001037:Aphasia / Q000235:genetics / Q000473:pathology; D001923:Brain Chemistry; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism; D006429:Hemiplegia / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008881:Migraine Disorders / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D009422:Nervous System Diseases / Q000150:complications / Q000473:pathology*; D014055:Tomography, Emission-Computed; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D005947:Glucose