title: Serial fMRI of adaptive changes in primary sensorimotor cortex following thumb reconstruction.
abstract: Serial fMRI was performed in a patient who underwent transfer of the left great toe to the hand following amputation of the right thumb. Motor activation within the primary sensorimotor cortex (SMC) of both hemispheres was quantified over 2 years, showing a transient increase in contralateral but not ipsilateral primary SMC. The temporal pattern of motor cortical activation observed in this patient may represent a "signature" of good functional recovery.
authors.affiliation: Faculty of Medicine, University of Toronto, Toronto, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Manduch
authors.forename: M
authors.initials: M
authors.lastname: Bezuhly
authors.forename: D J
authors.initials: DJ
authors.lastname: Anastakis
authors.forename: A P
authors.initials: AP
authors.lastname: Crawley
authors.forename: D J
authors.initials: DJ
authors.lastname: Mikulis
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods; D012044:Regression Analysis; D013003:Somatosensory Cortex / Q000502:physiology*; D013933:Thumb / Q000601:surgery*