Mitochondrial DNA 5178A polymorphism and longevity.
Previous studies have shown that mitochondrial DNA (mtDNA) 5178 adenine/cytosine (5178A) polymorphism, which is one of the haplogroup-specific mutations for mtDNA haplogroup D, was apparently associated with aging and longevity in humans. We genotyped the 5178A in 293 samples representing three age groups (Old, n=95; Young, n=103; and Infant, n=95) from Yunnan Province, China. The distribution frequency of the 5178A in the Old samples (16.84%) is slightly higher than in those of the Young (13.59%) and Infant (15.79%), but the frequency difference between the age groups is far from being statistically significant ( P>0.05). Our results fail to support the suggestion of association between mtDNA 5178A (or haplogroup D) and longevity.
Yao
Yong-Gang
YG
Graduate School of The Chinese Academy of Sciences, Beijing, China.
Kong
Qing-Peng
QP
Zhang
Ya-Ping
YP
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D007223:Infant; D008136:Longevity / Q000235:genetics*; D011110:Polymorphism, Genetic
D004272:DNA, Mitochondrial