title: Telomerase: a target for cancer therapeutics.
abstract: The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75309, USA. jerry.shay@utsouthwestern.edu
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Shay
authors.forename: Woodring E
authors.initials: WE
authors.lastname: Wright
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D007167:Immunotherapy; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D016337:RNA, Catalytic / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D016376:Oligonucleotides, Antisense; D016337:RNA, Catalytic; D018894:Reverse Transcriptase Inhibitors; D019098:Telomerase