Genetic susceptibility to aminoglycoside ototoxicity: how many are at risk?
OBJECTIVE
To assess the occurrence of two mutations associated with susceptibility to aminoglycoside ototoxicity.


METHODS
Genetic analysis of anonymized, residual diagnostic specimens.


RESULTS
One occurrence of the A1555G mutation and seven occurrences of the 961delT + C(n) nucleotide change were found. Two previously unreported sequence changes, T961G and 956-960insC, were also found in six and five specimens, respectively.


CONCLUSIONS
Genetic susceptibility to aminoglycoside ototoxicity may be more common than previously suspected. Further study of the 961delT + C(n) mutation is recommended to confirm its role in aminoglycoside ototoxicity and assess penetrance and variability with and without exposure to aminoglycoside antibiotics.
Tang
Hsiao-Yuan
HY
The Bobby R. Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.
Hutcheson
Eldridge
E
Neill
Susan
S
Drummond-Borg
Margaret
M
Speer
Michael
M
Alford
Raye Lynn
RL
D000483:Alleles; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D044383:Black People / Q000235:genetics; D004247:DNA / Q000097:blood / Q000235:genetics; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000737:chemistry; D003638:Deafness / Q000139:chemically induced* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D015997:Neonatal Screening; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics; D001741:Black or African American
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D017931:DNA Primers; D004247:DNA