Acute interstitial nephritis due to nicergoline (Sermion).
We report a case of acute interstitial nephritis (AIN) due to nicergoline (Sermion). A 50-year-old patient admitted to our hospital for fever and acute renal failure. Before admission, he had been taking nicergoline and bendazac lysine due to retinal vein occlusion at ophthalmologic department. Thereafter, he experienced intermittent fever and skin rash. On admission, clinical symptoms (i.e. arthralgia and fever) and laboratory findings (i.e. eosinophilia and renal failure) suggested AIN, and which was confirmed by pathologic findings on renal biopsy. A lymphocyte transformation test demonstrated a positive result against nicergoline. Treatment was consisted of withdrawal of nicergoline and intravenous methylprednisolone, and his renal function was completely recovered. To our knowledge, this is the first report of nicergoline-associated AIN.
Kim
Mi Jeong
MJ
Department of Internal Medicine and Clinical Pathology, Kangnam St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.
Chang
Jae Hyuck
JH
Lee
Suk Kyeong
SK
Park
Joo Hyun
JH
Choi
Yeong Jin
YJ
Yang
Chul Woo
CW
Kim
Yong Soo
YS
Park
Sung Hak
SH
Bang
Byung Kee
BK
D000208:Acute Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D009530:Nicergoline / Q000009:adverse effects*; D012170:Retinal Vein Occlusion / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000009:adverse effects*
D014665:Vasodilator Agents; D009530:Nicergoline