title: Anaphylactic reaction to isosulfan blue used for sentinel node biopsy: case report and literature review.
abstract: Isosulfan blue is a commonly used agent in the detection of sentinel lymph nodes during cancer surgery. Similar to any drug, it is possible to have an allergic reaction to this increasingly popular chemical during breast cancer operations. We present one case of anaphylactic shock in response to injection of isosulfan blue for the purpose of localizing the sentinel node and review the medical literature. A thorough knowledge of possible isosulfan blue side effects, including their presentation and subsequent therapy, is essential for the modern breast surgeon.
authors.affiliation: Department of Surgery, Shands Hospital, University of Florida, Gainsville, FL 32610, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Efron
authors.forename: Ellen
authors.initials: E
authors.lastname: Knudsen
authors.forename: Stephen
authors.initials: S
authors.lastname: Hirshorn
authors.forename: Edward M
authors.initials: EM
authors.lastname: Copeland
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012394:Rosaniline Dyes / Q000009:adverse effects*; D021701:Sentinel Lymph Node Biopsy / Q000009:adverse effects* / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012394:Rosaniline Dyes; C025484:iso-sulfan blue