title: Clinical use of lopinavir/ritonavir in a salvage therapy setting: pharmacokinetics and pharmacodynamics.
abstract: Lopinavir/ritonavir was administered to 35 HIV-infected patients after therapeutic failure with other protease inhibitors. The pharmacokinetics (trough concentrations) and baseline viral genotype were determined, together with the immunovirological outcome. The 22 responders had significantly higher mean lopinavir concentrations and lower baseline numbers of mutations. On multivariate analysis, a lopinavir concentration of 5.7 microg/ml or greater was an independent predictor of viral suppression over a 9-month follow-up period.
authors.affiliation: Department of Infectious Diseases, University of Torino, Turin, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Boffito
authors.forename: Isabella
authors.initials: I
authors.lastname: Arnaudo
authors.forename: Riccardo
authors.initials: R
authors.lastname: Raiteri
authors.forename: Stefano
authors.initials: S
authors.lastname: Bonora
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sinicco
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Garbo
authors.forename: Helen E
authors.initials: HE
authors.lastname: Reynolds
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Hoggard
authors.forename: David J
authors.initials: DJ
authors.lastname: Back
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Perri
mesh_terms: D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D016333:HIV Protease / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D061466:Lopinavir; D008297:Male; D009154:Mutation; D011744:Pyrimidinones / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019438:Ritonavir / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016879:Salvage Therapy; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D016333:HIV Protease; D019438:Ritonavir