The TCR/CD3 complex: molecular interactions in a changing structure.
The T cell receptor-CD3 (TCR/CD3) complex is a multichain structure in charge of antigen recognition in T cells. Despite many genetic, structural, and functional data obtained in recent years, essential questions concerning the TCR/CD3 complex still remain open, including: 1) the precise number of polypeptides in each TCR/CD3 complex, their interactions and spatial arrangement, 2) the role(s) of each polypeptide in antigen recognition and/or in receptor signal transmission, and 3) the relationship between the TCR/CD3 complex and other membrane or cytoplasmic molecules involved in downstream signaling. In this work we shall review data concerning some of these issues, proposing a model of the overall structure of the TCR/CD3 complex to explain its known features.
Feito
Maria José
MJ
Departmento de Inmunologia, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Jiménez-Periañez
Arturo
A
Ojeda
Gloria
G
Sánchez
Alejandra
A
Portolés
Pilar
P
Rojo
José M
JM
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D021122:Protein Subunits; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism
D021122:Protein Subunits; D017260:Receptor-CD3 Complex, Antigen, T-Cell