title: M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH).
abstract: Mutations of the AML1 gene are frequent molecular abnormalities in minimally differentiated acute myeloblastic leukemia (M0 AML), a rare type of AML. In this retrospective multicenter study, morphologic, immunophenotypical, cytogenetic, and molecular features of 59 de novo M0 AML cases were analyzed and correlated to AML1 mutations. Point mutations of AML1 gene were observed in 16 cases (27%). They were correlated with higher white blood cell (WBC) count (P =.001), greater marrow blast involvement (P =.03), higher incidence of immunoglobulin H/T-cell receptor (IgH/TCR) gene rearrangement (P <.0001), and with a borderline significant lower incidence of complex karyotypes. In the 59 patients, FLT3 mutations were the only significant prognostic factors associated with short survival.
authors.affiliation: Laboratoire d'Hématologie A, Laboratoire de Cytogénétique, and Service des Maladies du Sang, CHU Lille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Roumier
authors.forename: Virginie
authors.initials: V
authors.lastname: Eclache
authors.forename: Michelle
authors.initials: M
authors.lastname: Imbert
authors.forename: Frederic
authors.initials: F
authors.lastname: Davi
authors.forename: Elizabeth
authors.initials: E
authors.lastname: MacIntyre
authors.forename: Richard
authors.initials: R
authors.lastname: Garand
authors.forename: Pascaline
authors.initials: P
authors.lastname: Talmant
authors.forename: Pascale
authors.initials: P
authors.lastname: Lepelley
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Lai
authors.forename: Olivier
authors.initials: O
authors.lastname: Casasnovas
authors.forename: Marc
authors.initials: M
authors.lastname: Maynadie
authors.forename: Francine
authors.initials: F
authors.lastname: Mugneret
authors.forename: Chrystele
authors.initials: C
authors.lastname: Bilhou-Naberra
authors.forename: Francoise
authors.initials: F
authors.lastname: Valensi
authors.forename: Isabelle
authors.initials: I
authors.lastname: Radford
authors.forename: Marie Joelle
authors.initials: MJ
authors.lastname: Mozziconacci
authors.forename: Christine
authors.initials: C
authors.lastname: Arnoulet
authors.forename: Eliane
authors.initials: E
authors.lastname: Duchayne
authors.forename: Nicole
authors.initials: N
authors.lastname: Dastugue
authors.forename: Pascale
authors.initials: P
authors.lastname: Cornillet
authors.forename: Sylvie
authors.initials: S
authors.lastname: Daliphard
authors.forename: Francine
authors.initials: F
authors.lastname: Garnache
authors.forename: Najiba
authors.initials: N
authors.lastname: Boudjerra
authors.forename: Helene
authors.initials: H
authors.lastname: Jouault
authors.forename: Odile
authors.initials: O
authors.lastname: Fenneteau
authors.forename: Béatrice
authors.initials: B
authors.lastname: Pedron
authors.forename: Roland
authors.initials: R
authors.lastname: Berger
authors.forename: Georges
authors.initials: G
authors.lastname: Flandrin
authors.forename: Pierre
authors.initials: P
authors.lastname: Fenaux
authors.forename: Claude
authors.initials: C
authors.lastname: Preudhomme
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics*; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D007958:Leukocyte Count; D008875:Middle Aged; D017354:Point Mutation; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012189:Retrospective Studies; D015996:Survival Rate; D014157:Transcription Factors / Q000235:genetics*; D051941:fms-Like Tyrosine Kinase 3
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; D011948:Receptors, Antigen, T-Cell; D014157:Transcription Factors; C497970:FLT3 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3