Bioactive constituents from Iryanthera megistophylla.
Activity-guided fractionation of the 95% ethanol extract from the stem bark of Iryanthera megistophylla led to the isolation of two new compounds, named megislignan [2,3-dimethyl-4-(4-methoxyphenyl)-6-hydroxynaphthalene] (1) and megislactone [(2R,3R,4R)-3-hydroxy-4-methyl-2-(hexacos-17-enyl)butanolide] (2), along with seven known compounds, grandinolide (3), iryantherin K (4), iryantherin L (5), cinchonain I b (6), cinchonain I a (7), procyanidin B-2 (8), and cinchonain IIa (9). The structures of the new compounds were elucidated by spectral data interpretation. Isolates were evaluated for their antibacterial, antifungal, antiviral, and antiacetylcholinesterase activities.
Ming
Dong Sheng
DS
Department of Botany, University of British Columbia, #3529-6270 University Boulevard, Vancouver, Canada V6T 1Z4.
López
Andrés
A
Hillhouse
Brian J
BJ
French
Christopher J
CJ
Hudson
Jim B
JB
Towers
G H Neil
GH
D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification*; D026324:Myristicaceae / Q000737:chemistry*; D013057:Spectrum Analysis
D001685:Biological Factors