CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons.
We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily. Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS. This gene is therefore implicated in CNS development, in particular in granule cell development.
Lee
Ching-Jung
CJ
Children's Brain Tumour Research Centre, Institute of Genetics, University of Nottingham, Queen's Medical Centre, UK.
Chan
Wai-In
WI
Cheung
Martin
M
Cheng
Yi-Chuan
YC
Appleby
Vanessa J
VJ
Orme
Alex T
AT
Scotting
Paul J
PJ
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D020224:Expressed Sequence Tags; D015723:Gene Library; D017344:Genes, Insect / Q000235:genetics; D006609:High Mobility Group Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009474:Neurons / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D014018:Tissue Distribution
C498610:CIC protein, human; C498611:Cic protein, mouse; D006609:High Mobility Group Proteins; D012097:Repressor Proteins