title: Maintenance hemodialysis and circulating ionized magnesium.
abstract: BACKGROUND
  Circulating magnesium exists in the bound and in the free ionized form, that is biologically active. In kidney disease the relationship between ionized and total circulating magnesium is often altered. Little information is available on the influence of hemodialysis on the relationship between ionized and total circulating magnesium in end-stage kidney disease.
  
  
  METHODS
  Plasma total and ionized magnesium and the plasma ionized magnesium fraction were assessed before and after hemodialysis (dialysate magnesium content 0.75 mmol/l) in 46 patients with end-stage kidney disease and in a control group of 25 healthy subjects.
  
  
  RESULTS
  In patients plasma total (from 1.19 [1.05-1.33] to 1.10 [1.02-1.16] mmol/l; median and interquartile range) and ionized (from 0.71 [0.66-0.78] to 0.65 [0.63-0.69] mmol/l) magnesium significantly decreased during dialysis (control subjects: 0.82 [0.80-0.92], respectively, 0.57 [0.54-0.59] mmol/l). The plasma ionized magnesium fraction was significantly lower in patients both before (0.61 [0.58-0.64)] and after (0.60 [0.56-0.62]) hemodialysis than in controls (0.68 [0.65-0.70]).
  
  
  CONCLUSIONS
  The study demonstrates a tendency towards a reduced circulating ionized magnesium fraction in end-stage kidney disease that is not corrected by hemodialysis.
authors.affiliation: Inselspital, University of Berne, Switzerland.
authors.forename: Anita C
authors.initials: AC
authors.lastname: Truttmann
authors.forename: Rita
authors.initials: R
authors.lastname: Faraone
authors.forename: Rodo O
authors.initials: RO
authors.lastname: Von Vigier
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Nuoffer
authors.forename: Roger
authors.initials: R
authors.lastname: Pfister
authors.forename: Mario G
authors.initials: MG
authors.lastname: Bianchetti
mesh_terms: D000136:Acid-Base Equilibrium; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000628:therapy
chemical_list: D008274:Magnesium