Retrospective clinical comparison of Celsior solution to modified blood Wallwork solution in lung transplantation for cystic fibrosis.
OBJECTIVE
To compare the preservative effects of Celsior solution and modified blood Wallwork solution in lung transplantation.


METHODS
From 1989 to 2000, 44 lung transplantations for cystic fibrosis were performed: 26 grafts were preserved with modified blood Wallwork solution and 18 with Celsior solution.


RESULTS
Preoperative status of the 2 groups was similar. The ratio of arterial oxygen to fraction of inspired oxygen and the pulmonary vascular resistance on the first postoperative day did not differ significantly between the 2 groups. Early death was 4% (SD, 20%) in the Wallwork group versus 11% (SD, 32%) in the Celsior group (not significant). No death was related to graft failure. The forced expiratory volume in 1 second during the first month after transplantation was 63% (SD, 19%) in the Wallwork group versus 63% (SD, 16%) in the Celsior group (not significant).


CONCLUSIONS
Because the solution does not need to be prepared on site and does not require blood from the donor, Celsior seems better than Wallwork solution for preserving lung grafts.
Baron
O
O
Thoracic Transplantation Unit, Cardiovascular Surgery Department, Laennec Hospital, Nantes, France.
Fabre
S
S
Haloun
A
A
Treilhaud
M
M
al Habasch
O
O
Duveau
D
D
Michaud
J L
JL
Despins
P
P
D000418:Albumins / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000601:surgery*; D004187:Disaccharides / Q000494:pharmacology*; D004573:Electrolytes / Q000494:pharmacology*; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology*; D006639:Histidine / Q000494:pharmacology*; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000601:surgery*; D016040:Lung Transplantation; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*; D017027:Protein Tyrosine Phosphatases / Q000494:pharmacology*; D012189:Retrospective Studies
D000418:Albumins; C088453:Celsior; D002712:Chlorides; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D019188:Organ Preservation Solutions; D011422:Propionates; C089639:Wallwork solution; D008353:Mannitol; D006639:Histidine; D010749:Phosphoprotein Phosphatases; D017027:Protein Tyrosine Phosphatases; D005978:Glutathione