Triazine-human serum albumin association: thermodynamic approach and sodium effect.
Human serum albumin (HSA) serves as a carrier protein to transport triazine herbicides to molecular targets. In this paper, a theoretical treatment was developed to describe the HSA-triazine herbicides association. A determination of the association constant, K, as well as the degree of complexation n(c) (the percent of complex guest) was carried out. Enthalpy-entropy compensation was also analyzed in relation to this mathematical model to confirm the herbicide complexation behavior with HSA. The role of the sodium cation (Na(+)) on this association was investigated. It was expected that the sodium ion would act on the herbicide-HSA association process by modifying the surface tension of the bulk solvent and increase the K and n(c) values. The results showed that for patients who suffer from Na(+) desequilibrium, the triazine-HSA binding would change and as well the toxicological effect of these herbicides.
Ismaili
Lhassane
L
Laboratoire de la Chimie Analytique, Faculté de Médecine-Pharmacie, Université de Franche-Comte, Place Saint Jacques, 25030 Besançon Cedex, France.
André
Claire
C
Nicod
Laurence
L
Truong
Tong Thanh
TT
Millet
Joëlle
J
Thomassin
Mireille
M
Cavalli
Eric
E
Chaumont
Jean Pierre
JP
Xicluna
Alain
A
Guillaume
Yves Claude
YC
D006540:Herbicides / Q000378:metabolism*; D006801:Humans; D012709:Serum Albumin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D013816:Thermodynamics; D014227:Triazines
D006540:Herbicides; D012709:Serum Albumin; D014227:Triazines; D012964:Sodium