title: Pharmacological studies on Puerariae Flos. IV: Effects of Pueraria thomsonii dried flower extracts on blood ethanol and acetaldehyde levels in humans.
abstract: We investigated the effects of extracts from the dried flower of Pueraria thomsonii on blood ethanol and acetaldehyde levels in humans consuming alcoholic beverages. The extracts of Pueraria thomsonii had no influence on blood ethanol and acetaldehyde concentration in humans. However, the extracts increased the elimination rate constant of blood acetaldehyde, although they had no effect on the elimination of blood ethanol in humans. These results suggest that Pueraria thomsonii promotes the elimination of blood acetaldehyde in humans. The present study clinically suggests that a modest stimulatory effect of Pueraria thomsonii on the elimination of blood acetaldehyde may passively mitigate acetaldehyde toxicity, such as flushing, palpitation, headache, etc., associated with excessive alcohol intake.
authors.affiliation: Tsukuba Research Institute, Ohat's Isan Co. Ltd., Ushiku, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Hosono
authors.forename: Y
authors.initials: Y
authors.lastname: Matsushita
authors.forename: K
authors.initials: K
authors.lastname: Kawashima
authors.forename: M
authors.initials: M
authors.lastname: Someya
authors.forename: Y
authors.initials: Y
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Narui
authors.forename: Y
authors.initials: Y
authors.lastname: Hibi
authors.forename: M
authors.initials: M
authors.lastname: Ishizaki
authors.forename: J
authors.initials: J
authors.lastname: Kinjo
authors.forename: T
authors.initials: T
authors.lastname: Nohara
mesh_terms: D000079:Acetaldehyde / Q000097:blood*; D000328:Adult; D000428:Alcohol Drinking / Q000097:blood / Q000378:metabolism*; D018592:Cross-Over Studies; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D029908:Pueraria
chemical_list: D004365:Drugs, Chinese Herbal; C442841:Puerariae Flos extract; D000431:Ethanol; D000079:Acetaldehyde