Clinical significance of the antibody against oxidized low-density lipoprotein in acute myocardial infarction.
To establish the clinical significance of the antibody against oxidized low-density lipoprotein (anti-Ox-LDL) titer in patients with acute myocardial infarction (AMI), we measured the anti-Ox-LDL titer in 39 patients with AMI and 25 controls. In all AMI patients, the anti-Ox-LDL titer on admission was higher (p < 0.05) than the value in the controls. One month after admission, the titer decreased significantly (p < 0.001) reaching control levels. In patients who underwent thrombolytic therapy, the anti-Ox-LDL titer on admission was identical in patients with occluded infarct-related arteries (IRA) and patients with patent IRA during emergency coronary angiography. In patients who did not undergo thrombolytic therapy, the anti-Ox-LDL titer on admission was higher in patients with occluded IRA than in patients with patent IRA. An increased anti-Ox-LDL titer may be a risk factor for the onset of AMI. Spontaneous recanalization of the IRA may be associated with increased anti-Ox-LDL titers, while thrombolysis-induced recanalization may be independent of it.
Inoue
Teruo
T
Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya City, Japan. inouet@dokkyomed.ac.jp
Yaguchi
Isao
I
Uchida
Toshihiko
T
Kamishirado
Hirotoshi
H
Nakahara
Shiro
S
Hayashi
Terumi
T
Morooka
Shigenori
S
D000906:Antibodies / Q000627:therapeutic use*; D001158:Arteries / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D008078:Cholesterol, LDL / Q000187:drug effects / Q000378:metabolism; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D007564:Japan; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D010343:Patient Admission; D011446:Prospective Studies; D016896:Treatment Outcome; D014654:Vascular Patency / Q000187:drug effects / Q000502:physiology
D000906:Antibodies; D015415:Biomarkers; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein