Preliminary evaluation of Kielmeyera coriacea leaves extract on the central nervous system.
The hydroalcoholic extract of Kielmeyera coriacea leaves was evaluated for effects on the central nervous system by means of behavioral models which included forced swimming, open-field and elevated plus-maze tests. According to the results, K. coriacea leaves extract is effective as anxiolytic but not as an antidepressant drug.
Audi
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EA
Department of Pharmacy and Pharmacology, Universidade Estadual de Maringá, PR, Brazil. eaaudi@uem.br
Otobone
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Martins
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Cortez
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D000284:Administration, Oral; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D028084:Clusiaceae; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010936:Plant Extracts; D007099:Imipramine; D003975:Diazepam