Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry.
Rapid and simple chiral analysis of thalidomide solutions is demonstrated by using electrospray ionization tandem mass spectrometry and analysis of cluster ion dissociation by the kinetic method. Average deviations of 1% between the actual and experimental enantiomeric compositions are observed.
Augusti
Daniella V
DV
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Augusti
Rodinei
R
Carazza
Fernando
F
Cooks
R Graham
RG
D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013237:Stereoisomerism; D013792:Thalidomide / Q000737:chemistry*
D012996:Solutions; D013792:Thalidomide