[Cross-talk between the natriuretic peptide system and the angiotensin system].
The natriuretic peptide comprises at least three ligands(ANP, BNP, and CNP) and three receptors(GC-A, GC-B, and Clearance receptor). ANP and BNP are cardiac hormones, which regulate blood pressure and body fluid volume. Angiotensin II, the effector peptide of the renin-angiotensin system, regulates cellular growth in response to developmental, physiological and pathological processes. Recently, evidences suggest that cardiovascular homeostasis is determined by the balance between these two important counter-regulatory pathways. In this paper, we will discuss the molecular mechanism of the cross-talk between the two systems, including our recent findings using the mice deficient for GC-A and angiotensin II receptors. The results suggest that the endogenous natriuretic peptide system inhibits the cardiac angiotensin system and protects the heart from excessive pathological remodelings.
Kishimoto
Ichiro
I
Kyoto University School of Medicine, Department of Medicine and Clinical Science.
Saito
Yoshihiko
Y
Li
Yuhao
Y
Nakao
Kazuwa
K
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D051379:Mice; D020097:Natriuretic Peptide, Brain / Q000502:physiology*; D020239:Receptor Cross-Talk / Q000502:physiology; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D012084:Renin-Angiotensin System / Q000502:physiology*
D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor