Antimicrobial resistance in Haemophilus influenzae isolated during population-based surveillance for meningitis in Salvador, Brazil.
Antimicrobial susceptibility was determined for 150 Haemophilus influenzae isolates obtained during population-based surveillance for meningitis in Salvador, Brazil. Ten (6.7%) isolates were resistant to ampicillin and chloramphenicol. Of these, two isolates, a beta-lactamase and non-beta-lactamase producer, were resistant to amoxacillin-clavulinic acid. These findings indicate that present antibiotic regimens in Brazil may not be appropriate for the treatment of H. influenzae meningitis.
Reis
Joice Neves
JN
Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde. Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
Lima
Josilene Borges
JB
Ribeiro
Guilherme Souza
GS
Corderio
Soraia Machado
SM
Salgado
Kátia
K
Reis
Mitermayer Galvão
MG
Ko
Albert I
AI
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D018073:Haemophilus Vaccines / Q000191:economics / Q000627:therapeutic use; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D001618:beta-Lactamases / Q000378:metabolism
D018073:Haemophilus Vaccines; D019980:Amoxicillin-Potassium Clavulanate Combination; D001618:beta-Lactamases