A versatile approach to affinitychromic polythiophenes.
The preparation of both postfunctionalizable and chromic poly[3-(N-succinimido-p-phenylcarboxylate(tetraethoxy)oxy)-4-methylthiophene] is reported. The N-hydroxysuccinimide ester side group can easily react with different amine-bearing molecules in the solid state to yield a library of new polythiophene derivatives. The resulting polymers can be dissolved in various solvents, and interactions between the side chains (ligands) and different analytes (targets) can be detected from modifications of both the side-chain and the backbone conformations resulting in important color changes (i.e., affinitychromism). This colorimetric polymeric transducer could therefore lead to highly valuable, versatile, and inexpensive tools for highthroughput screening and drug discovery.
Bernier
Stéphanie
S
Canada Research Chair in Electroactive and Photoactive Polymers, Centre de recherche en sciences et ingénierie des macromolécules, Département de Chimie, Université Laval, Quebec City, Qc, Canada, G1K 7P4.
Garreau
Sébastien
S
Béra-Abérem
Maïté
M
Gravel
Catherine
C
Leclerc
Mario
M
D002626:Chemistry, Pharmaceutical; D004359:Drug Therapy, Combination; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
D011108:Polymers; D013876:Thiophenes