title: Relearning face-name associations in early Alzheimer's disease.
abstract: Preliminary evidence for the effectiveness of cognitive rehabilitation interventions based on errorless learning principles in early-stage Alzheimer's disease (AD) was provided by Clare et al. (1999, 2000, 2001). The present study extends these findings in a controlled trial. Twelve participants meeting criteria for probable AD, with Mini-Mental State Examination scores of 18 or above, were trained in face-name associations using an errorless learning paradigm. Training produced a significant group improvement in recall of trained, but not control, items. Gains were largely maintained 6 months later, in the absence of practice. There were differences in individual response to intervention. Results did not differ according to medication status, and the intervention had no adverse effects on self-reported well-being, but participants who were more aware of their memory difficulties achieved better outcomes.
authors.affiliation: Sub-Department of Clinical Health Psychology, University College London, England. l.clare@ucl.ac.uk
authors.forename: Linda
authors.initials: L
authors.lastname: Clare
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Wilson
authors.forename: Gina
authors.initials: G
authors.lastname: Carter
authors.forename: Ilona
authors.initials: I
authors.lastname: Roth
authors.forename: John R
authors.initials: JR
authors.lastname: Hodges
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005145:Face; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000628:therapy*; D008875:Middle Aged; D009275:Names; D009483:Neuropsychological Tests
chemical_list: D002800:Cholinesterase Inhibitors