Diffuse large B-cell lymphoma with infiltration-associated peripheral neuropathy and paraneoplastic myopathy with a prolonged course over seven years.
Rarely lymphoproliferative disorders (LPD) may be associated with peripheral neuropathy, based on different mechanisms of pathogenesis. Here, we report a case of a primary extranodal diffuse large B-cell lymphoma which showed a prolonged course with several recurrences manifesting as neuropathies, and long term remissions achieved by chemotherapy and involved field radiation. Repeated pathohistologic evaluations showed spread of lymphoma growth predominantly along nerve structures, suggesting neurotropism of the lymphoma cells.
Fiegl
M
M
Department of Internal Medicine, University of Innsbruck, Austria. michael.fiegl@uibk.ac.at
Muigg
A
A
Smekal
A
A
Krugmannd
J
J
Dirnhofer
S
S
Greil
R
R
D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000209:etiology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*