title: Further evidence for the involvement of cardiac beta-adrenergic receptors in right ventricle hypertrophy and ascites in broiler chickens.
abstract: The present study was carried out to determine, first, the cardiac beta-adrenergic receptor characteristics of broiler chick embryos exposed to two different CO(2) levels during the last stage of embryonic development, and second, the prophylactic effect of beta(1)-adrenoceptor blocker on right ventricular hypertrophy in broiler chickens. High CO(2) embryos showed significantly higher haematocrit values, higher partial pressure of CO(2) levels and lower partial pressure of O(2) levels than those of normal CO(2) embryos. Exposure of chick embryos to high CO(2) levels reduced the binding capacity of myocardial beta-adrenergic receptors compared with those embryos incubated at the normal CO(2) level. Atenolol-supplemented diet numerically reduced ascites incidence in broiler chickens (7%) compared with birds fed the control diet (15%). In conclusion, these data support the important role of the beta-adrenergic receptor in the cardiovascular system for cardiac output, and secondary to pulmonary hypertension syndrome.
authors.affiliation: Department of Poultry Diseases, Faculty of Veterinary Medicine, University of Tehran, P.O. Box 14155-6453, Tehran, Iran. Mhzadeh@Chamran.ut.ac.ir
authors.forename: M
authors.initials: M
authors.lastname: Hassanzadeh
authors.forename: J
authors.initials: J
authors.lastname: Buyse
authors.forename: E
authors.initials: E
authors.lastname: Decuypere
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002642:Chick Embryo / Q000502:physiology; D002645:Chickens; D006321:Heart / Q000503:physiopathology*; D006400:Hematocrit / Q000662:veterinary; D017380:Hypertrophy, Right Ventricular / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D010100:Oxygen / Q000097:blood; D011201:Poultry Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
chemical_list: D011943:Receptors, Adrenergic, beta; D002245:Carbon Dioxide; D010100:Oxygen