Synthesis and immunological effect of thymic humoral factor-gamma 2 analogues.
Nine analogues of thymic humoral factor (THF)-gamma 2 were prepared by the solid-phase method and their in vitro restoring effect on the impaired blastogenic response of phytohemagglutinin(PHA)-stimulated T-lymphocytes of uremic patients with infectious diseases were examined. The results were as follows: [Arg6]-THF-gamma 2 exhibited higher restoring activity than that of our synthetic THF-gamma 2. [Sar4]-, [Val1]-, [Arg3]-, [Gly5]-, and [Asn3]-THF-gamma 2 were also active, but less potent than that of our synthetic THF-gamma 2. Three other peptides, [beta Ala4]-, [Arg2]-, and [Gln2]-THF-gamma 2, did not show any restoring activity on the impaired blastogenic response of uremic patients with infectious disease.
Abiko
T
T
Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd., Sendai, Japan. abiko@ma.nmi.ne.jp
Ogawa
R
R
D006801:Humans; D009842:Oligopeptides / Q000138:chemical synthesis / Q000276:immunology / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D014511:Uremia / Q000188:drug therapy
D009842:Oligopeptides; D010455:Peptides; C064563:thymic humoral factor gamma 2