title: Single photon emission computerized tomography of spongiform leukoencephalopathy heroin addicts: analysis of 10 cases.
abstract: OBJECTIVE
  To investigate the changes in cerebral circulation in heroin addicts with pongiform leukoencephalopathy.
  
  
  METHODS
  Single photon emission computerized tomography (SPECT) was performed in 10 such patients.
  
  
  RESULTS
  Regional cerebral blood flow (rCBF) in the involved white matter of bilateral cerebral and cerebellar hemispheres was obviously reduced. rCBF of temporal lobes, parietal lobes, cerebellar hemispheres and basal ganglion were reduced in varying degrees.
  
  
  CONCLUSIONS
  As demonstrated by the result of SPECT, rCBF in the white matter of bilateral cerebral and cerebellar hemispheres was reduced with partial involvement of the gray matter of heroin addicts with spongiform leukoencephalopathy.
authors.affiliation: Department of Neurology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Bing-Xun
authors.initials: BX
authors.lastname: Lu
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000098:blood supply*; D007562:Creutzfeldt-Jakob Syndrome / Q000503:physiopathology; D006556:Heroin Dependence / Q000503:physiopathology*; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000503:physiopathology*; D008297:Male; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*