title: Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia.
abstract: In this study, we evaluated the prognostic significance of multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF4) expression in B-cell chronic lymphocytic leukemia (B-CLL). Our results demonstrated that the absence of MUM1/IRF4 expression showed the highest relative risk among the factors analyzed in determining the probability for death in patients with B-CLL using univariate and multivariate Cox regression analysis. Patients without MUM1/IRF4 expression had significantly worse overall survival than did those with MUM1/IRF4 expression (52% cumulative survival, 63 months vs not reached, Kaplan-Meier survival analysis; P <.03, log-rank test). Patients with MUM1/IRF4 expression were more likely to have disease at low Rai stage and interstitial/nodular marrow involvement. Furthermore, only 1 of 11 patients with MUM1/IRF4 expression and interstitial/nodular marrow involvement died during a 100-month follow-up. Our results suggest that B-CLL with expression of MUM1/IRF4, indicative of postgerminal center origin, has a more favorable clinical course and that MUM1/IRF4 is an important prognostic marker in B-CLL.
authors.affiliation: Department of Pathology, Division of Hematology/Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA. jeffchang@pol.net
authors.forename: Chung-Che
authors.initials: CC
authors.lastname: Chang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lorek
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Sabath
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Chitambar
authors.forename: Brent
authors.initials: B
authors.lastname: Logan
authors.forename: Bal
authors.initials: B
authors.lastname: Kampalath
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Cleveland
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D006801:Humans; D050835:Interferon Regulatory Factors; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000401:mortality; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000032:analysis*; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D014157:Transcription Factors / Q000032:analysis*; D016896:Treatment Outcome; D000099218:Interferon Regulatory Factor-4
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D050835:Interferon Regulatory Factors; D009363:Neoplasm Proteins; D014157:Transcription Factors; D000099218:Interferon Regulatory Factor-4