title: A case of fatal necrotizing fasciitis after intramuscular administration of diclofenac.
abstract: Necrotizing fasciitis is a rapidly progressive soft tissue infection that involves subcutaneous fat and spreads along the fascial planes. This disease has a potentially fatal outcome if not recognized in early. Several cases have been reported of a possible association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the development or aggravation of necrotizing fasciitis. This association is still a subject of controversy. In this article we present a case of fatal necrotizing fasciitis occurring in association with intramuscular injections of diclofenac in a patient who was admitted for the symptoms of a urinary stone. Our opinion is that the intramuscular injections caused a locally aseptic necrosis, which was secondarily invaded by. Since this incident, our policy is to avoid the use of intramuscular injections of diclofenac and other NSAIDs in cases of potentially infectious diseases.
authors.affiliation: Emergency Department, AZ-VUB, Laarbeeklaan, Jette, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Verfaillie
authors.forename: S
authors.initials: S
authors.lastname: Knape
authors.forename: L
authors.initials: L
authors.lastname: Corne
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D019115:Fasciitis, Necrotizing / Q000139:chemically induced* / Q000503:physiopathology; D017809:Fatal Outcome; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D014545:Urinary Calculi / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac