Centriole duplication: centrin in on answers?
Many aspects of centriole biology remain mysterious. A new study has shed light on the role of the centriolar protein centrin-2: reducing levels of centrin-2 in HeLa cells has been found to block centriole duplication, eventually leading to cell death.
Rice
Luke M
LM
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.
Agard
David A
DA
D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology*; D016923:Cell Death; D002455:Cell Division; D002502:Centrioles / Q000502:physiology* / Q000648:ultrastructure*; D002868:Chromosomal Proteins, Non-Histone; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D034622:RNA Interference
D002135:Calcium-Binding Proteins; D002868:Chromosomal Proteins, Non-Histone; C056608:caltractin