Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1.
We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C- gamma 1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.
Kim
Sung Sook
SS
Department of Pathology, Medical School, University of Ulsan, Ulsan, Korea.
Eom
Daewoon
D
Huh
Jooryung
J
Sung
Iel-yong
IY
Choi
Inpyo
I
Ryu
Sung Ho
SH
Suh
Pann Ghill
PG
Chung
Sung-Min
SM
D016572:Cyclosporine / Q000009:adverse effects; D005260:Female; D005882:Gingival Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D006104:Granuloma, Plasma Cell / Q000139:chemically induced* / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015850:Interleukin-6 / Q000378:metabolism; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D051966:Phospholipase C gamma; D010738:Type C Phospholipases / Q000378:metabolism
D007166:Immunosuppressive Agents; D015850:Interleukin-6; D016572:Cyclosporine; D010738:Type C Phospholipases; D051966:Phospholipase C gamma