title: Human performance: a role for the ACE genotype?
abstract: The I allele of the angiotensin I-converting enzyme (ACE) gene is associated with lower ACE activity and endurance performance; an excess occurs in elite distance runners, rowers, and mountaineers, perhaps secondary to enhanced muscle efficiency. Conversely, the D allele is associated with training-related strength gain and elite power-oriented performance secondary to increased ACE and angiotensin II, a growth factor.
authors.affiliation: Department of Cardiovascular Genetics, Rayne Institute, University College London, UK.
authors.forename: Alun
authors.initials: A
authors.lastname: Jones
authors.forename: Hugh E
authors.initials: HE
authors.lastname: Montgomery
authors.forename: David R
authors.initials: DR
authors.lastname: Woods
mesh_terms: D000483:Alleles; D001920:Bradykinin / Q000235:genetics / Q000378:metabolism; D005819:Genetic Markers; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism; D010807:Physical Endurance / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D013647:Task Performance and Analysis
chemical_list: D005819:Genetic Markers; D007703:Peptidyl-Dipeptidase A; D001920:Bradykinin