Pathogenic significance of IgA receptor interactions in IgA nephropathy.
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, frequently progresses to renal failure. The pathogenesis of this disease involves the deposition of undergalactosylated IgA1 complexes in the glomerular mesangium. How the IgA1 complexes are generated and why they are deposited in the mesangium remains unclear. We propose a model wherein two types of IgA receptors participate in sequential steps to promote the development of IgAN, with FcalphaRI (CD89) being initially involved in the formation of circulating IgA-containing complexes and, subsequently, transferrin receptor (CD71) in mediating mesangial deposition of IgA1 complexes.
Monteiro
Renato C
RC
INSERM E0225, Bichat Medical School, 16, rue Henri Huchard, BP416, 75870 Paris Cédex 18, France. monteiro@bichat.inserm.fr
Moura
Ivan C
IC
Launay
Pierre
P
Tsuge
Toshinao
T
Haddad
Elie
E
Benhamou
Marc
M
Cooper
Max D
MD
Arcos-Fajardo
Michelle
M
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D005922:Glomerulonephritis, IGA / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D046911:Macromolecular Substances; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D011961:Receptors, Fc / Q000378:metabolism*; D011990:Receptors, Transferrin
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; C068126:CD71 antigen; C036832:Fc(alpha) receptor; D007070:Immunoglobulin A; D046911:Macromolecular Substances; D011961:Receptors, Fc; D011990:Receptors, Transferrin