Interaction of colony-stimulating factors and fluorodeoxyglucose f(18) positron emission tomography.
OBJECTIVE
To evaluate reports of altered diagnostic images with fluorodeoxyglucose F(18) (FDG) positron emission tomography (PET) after treatment with colony-stimulating factors (CSFs).


METHODS
Literature was identified by a MEDLINE search (1966-December 2001). Key search terms included granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, fluorodeoxyglucose, and emission-computed tomography. English language literature was reviewed.


RESULTS
Reports have suggested altered FDG PET images following CSF treatment. Studies that assessed the effect of CSF administration on FDG PET imaging of the bone and bone marrow were reviewed.


CONCLUSIONS
Administration of CSFs may interfere with accurate FDG PET imaging. Separating FDG PET imaging from CSF therapy by >/=5 days may diminish this interference.
Mayer
Dmitri
D
School of Pharmacy, Department of Pharmacy Practice and Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA.
Bednarczyk
Edward M
EM
D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D016022:Case-Control Studies; D004347:Drug Interactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D016178:Granulocyte-Macrophage Colony-Stimulating Factor