title: Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
abstract: There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.
authors.affiliation: Kennedy Institute of Rheumatology Division, Faculty of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK. mfeldmann@ic.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Feldmann
authors.forename: E
authors.initials: E
authors.lastname: Andreakos
authors.forename: C
authors.initials: C
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Bondeson
authors.forename: S
authors.initials: S
authors.lastname: Yoshimura
authors.forename: S
authors.initials: S
authors.lastname: Kiriakidis
authors.forename: C
authors.initials: C
authors.lastname: Monaco
authors.forename: C
authors.initials: C
authors.lastname: Gasparini
authors.forename: S
authors.initials: S
authors.lastname: Sacre
authors.forename: A
authors.initials: A
authors.lastname: Lundberg
authors.forename: E
authors.initials: E
authors.lastname: Paleolog
authors.forename: N J
authors.initials: NJ
authors.lastname: Horwood
authors.forename: F M
authors.initials: FM
authors.lastname: Brennan
authors.forename: B M J
authors.initials: BM
authors.lastname: Foxwell
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D017951:Antigen Presentation; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy*; D018929:Cell Culture Techniques; D003713:Dendritic Cells / Q000276:immunology; D005822:Genetic Vectors; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics; D007111:Immunity, Cellular; D007959:Lymphocyte Culture Test, Mixed; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000502:physiology; D013583:Synovial Membrane / Q000276:immunology
chemical_list: D020672:I-kappa B Proteins; D016328:NF-kappa B