Alcohol reduces insulin-hypertension relationship in a general population: the Hisayama study.
Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P =.003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P =.048 and.002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.
Arima
Hisatomi
H
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka City, Japan. harima@intmed2.med.kyushu-u.ac.jp
Kiyohara
Yutaka
Y
Kato
Isao
I
Tanizaki
Yumihiro
Y
Kubo
Michiaki
M
Iwamoto
Hiromitsu
H
Tanaka
Keiichi
K
Abe
Isao
I
Fujishima
Masatoshi
M
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000378:metabolism; D016009:Chi-Square Distribution; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015994:Incidence; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D014280:Triglycerides