Successful treatment of solar urticaria by extracorporeal photochemotherapy (photopheresis)--a case report.
Solar urticaria is characterized by erythema and whealing immediately after exposure to ultraviolet radiation and/or visible light. We report about a patient with severe solar urticaria, who was highly sensitive to both UVA radiation and visible light with a Minimal Urticaria Dose (MUD) of 7 J/cm2 UVA. Management of this patient was extremely difficult because standard treatment with oral antihistamines, hardening with UVA, UVB, visible light or oral PUVA and even oral cyclosporin A were completely ineffective. We therefore decided to perform extracorporeal photochemotherapy (photopheresis, ECP). After nine treatment cycles with photopheresis the MUD increased from 7 J/cm2 UVA before treatment to 22 J/cm2 UVA. This hardening effect was associated with a significant decrease of the frequency and severity of whealing and the accompanying symptoms (pain, fatigue, pruritus).


CONCLUSIONS
Photopheresis might be of some benefit in selected patients with otherwise intractable solar urticaria.
Mang
R
R
Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine University, Düsseldorf, Germany.
Stege
H
H
Budde
M-A
MA
Ruzicka
T
T
Krutmann
J
J
D006801:Humans; D008297:Male; D008875:Middle Aged; D017893:Photopheresis; D010787:Photosensitivity Disorders / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014581:Urticaria / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology