title: Crystallization and preliminary X-ray diffraction analysis of FKBP12 complexed with a novel neurotrophic ligand.
abstract: A novel neurotrophic ligand, (3R)-4-(p-Toluenesulfonyl)-1,4-thiazane-3-carboxylic acid-L-Leucine ethyl ester, has been complexed with FKBP12 and crystallized using the hanging-drop vapor-diffusion method. Crystals belong to P2(1) space group, with unit cell parameters a=41.2, b=29.6, c=41.5 A, beta=114.0 degrees. The crystals diffract to 1.8 A resolution limit.
authors.affiliation: Laboratory of Structural Biology, Department of Biological Science and Technology & MOE Laboratory of Protein Science, Tsinghua University, Beijing 100084, China.
authors.forename: Pengyun
authors.initials: P
authors.lastname: Li
authors.forename: Liwei
authors.initials: L
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Beili
authors.initials: B
authors.lastname: Wu
authors.forename: Cuiling
authors.initials: C
authors.lastname: Shu
authors.forename: Aihua
authors.initials: A
authors.lastname: Nie
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Beifen
authors.initials: B
authors.lastname: Shen
authors.forename: Zihe
authors.initials: Z
authors.lastname: Rao
mesh_terms: D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D022061:Tacrolimus Binding Protein 1A / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D008024:Ligands; D022061:Tacrolimus Binding Protein 1A