title: Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibit rat carotid contraction.
abstract: ent-Pimara-8(14),15-dien-19-oic acid (PA) isolated from Viguiera arenaria (Asteraceae; Heliantheae) inhibited rat carotid rings contraction induced by phenylephrine (10(-8) mol/l) or potassium chloride (45 mmol/l) at concentration ranging from 5 to 20 microg/ml. This inhibitory effect was not reversible after the removal of this compound from the medium bath.
authors.affiliation: Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, USP, Ribeirão Preto, Brazil.
authors.forename: Sergio R
authors.initials: SR
authors.lastname: Ambrosio
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Tirapelli
authors.forename: Daniella
authors.initials: D
authors.lastname: Bonaventura
authors.forename: Ana M
authors.initials: AM
authors.lastname: De Oliveira
authors.forename: Fernando B
authors.initials: FB
authors.lastname: Da Costa
mesh_terms: D000818:Animals; D019659:Asteraceae; D002339:Carotid Arteries / Q000187:drug effects*; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010656:Phenylephrine; D008517:Phytotherapy; D011189:Potassium Chloride; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D011189:Potassium Chloride; C008911:pimaric acid