title: Severe Churg-Strauss syndrome with mediastinal lymphadenopathy treated with interferon therapy.
abstract: We report a case of severe Churg-Strauss syndrome (CSS) with mediastinal eosinophilic lymphadenopathy, with relapse after standard therapy with steroids and cyclophosphamide, subsequently treated with interferon (IFN) alpha 2b. Our report shows that mediastinal lymph nodes mimicking lymphoma may be one of the clinical manifestations of CSS. We also show that patients with CSS who are resistant to first-line therapy and for whom hypereosinophilia is thought to play an important role may benefit from treatment with IFN.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Clinique Médicale A, Fédération des Services de Médecine Interne, Hôpital Civil, 1 place de l'Hôpital, B.P. 426, 67091 Cedex, Strasbourg, France
authors.forename: Olivier
authors.initials: O
authors.lastname: Lesens
authors.forename: Yves
authors.initials: Y
authors.lastname: Hansmann
authors.forename: Jacques
authors.initials: J
authors.lastname: Nerson
authors.forename: Jean
authors.initials: J
authors.lastname: Pasquali
authors.forename: Bernard
authors.initials: B
authors.lastname: Gasser
authors.forename: Jean
authors.initials: J
authors.lastname: Wihlm
authors.forename: D
authors.initials: D
authors.lastname: Christmann