[Effect of angiotensin II receptor blocker on insulin signaling in skeletal muscle cells].
Impairment of insulin-dependent glucose uptake in skeletal muscles plays a major role in the pathogenesis of diabetes mellitus. Angiotensin converting-enzyme inhibitor (ACEI) has been demonstrated to improve insulin-sensitivity in diabetic patients, partly through the increase in peripheral blood flow mediated by either suppressed angiotensin II or elevated bradykinin. Recently, angiotensin II type-1 receptor blocker (ARB) has been shown to produce similar effects, postulating the importance of intracellular signaling cross-talk between angiotensin II and insulin. In this brief review, we focused on insulin receptor substrate-1(IRS-1) in skeletal muscle cells, and the significance of its serine(612)-phosphorylation was discussed.
Kaihara
Masanobu
M
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry.
Nakamura
Yoshio
Y
Makino
Hirofumi
H
D057911:Angiotensin Receptor Antagonists; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D009210:Myofibrils / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology
D057911:Angiotensin Receptor Antagonists