title: O2 extraction during exercise determines training effect after cardiac rehabilitation in myocardial infarction.
abstract: Correlations between baseline hemodynamic and oximetric variables during an invasive exercise test and an improvement in peak oxygen uptake (peak VO2) after exercise training (ET) were examined in 20 patients who participated in a cardiac rehabilitation program after acute myocardial infarction (AMI). Peak VO2 significantly increased by 23 +/- 21% (p < 0.01) after ET and the improvement best correlated with the change in O2 extraction fraction ([arterial O2 content-venous O2 content]/arterial O2 content) during an exercise testbefore ET (r = -0.61, p<0.01). Exercise capacity was improved to a greater extent by ET in patients with a smaller increase in O2 extraction fraction during an exercise test before ET. Thus, O2 extraction fraction during an exercise test before ET may be a useful predictor of the improvement in exercise capacity after ET in post-AMI patients.
authors.affiliation: Department of Medicine, National Cardiovascular Center, National Cardiovascular Research Institute, Suita, Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Uchida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Okano
authors.forename: Toru
authors.initials: T
authors.lastname: Satoh
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Matsubara
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D015444:Exercise / Q000502:physiology*; D006334:Heart Function Tests; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000534:rehabilitation*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010809:Physical Fitness; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000737:chemistry
chemical_list: D010100:Oxygen