The association of sensitive systemic inflammation markers with bronchial asthma.
BACKGROUND
Airway inflammation is a characteristic feature of bronchial asthma. Previous studies have shown an increased local inflammatory activity in the airway mucosa of asthma patients.


OBJECTIVE
To analyze the association of asthma with three sensitive markers of systemic inflammation, C-reactive protein, serum amyloid-A (SAA), and plasma fibrinogen.


METHODS
A cross-sectional, population-based study including 1,513 Finnish men aged 45 to 74 years, who participated in a chronic disease risk factor survey in 1997. Of the participating men, 97 were classified as asthma patients. The odds ratios of asthma were analyzed by quartile of each inflammation marker.


RESULTS
In logistic regression models the age-adjusted odds ratios (second, third, and fourth quartile as compared with the first quartile) of asthma increased gradually with increasing quartile of C-reactive protein (1.28, 1.19, 1.96, P for trend = 0.039), SAA (1.20, 3.00, 3.49, P for trend < 0.001), and fibrinogen (1.22, 1.79, 3.16, P for trend < 0.001). The associations were independent of smoking. Further adjustment for waist-to-hip ratio, a marker of central obesity, and symptoms of chronic bronchitis weakened the observed association, but the increasing trend in the association of SAA and fibrinogen with asthma remained highly significant.


CONCLUSIONS
Sensitive markers of systemic inflammation, particularly SAA and fibrinogen, were positively and significantly associated with asthma prevalence. These findings support the hypothesis that not only local, but also systemic, inflammation exist in bronchial asthma.
Jousilahti
Pekka
P
University of Helsinki, Department of Public Health, Finland. pekka.jousilahti@ktl.fi
Salomaa
Veikko
V
Hakala
Katri
K
Rasi
Vesa
V
Vahtera
Elina
E
Palosuo
Timo
T
D000368:Aged; D001249:Asthma / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology*; D029481:Bronchitis, Chronic / Q000150:complications; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D005340:Fibrinogen / Q000032:analysis; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000097:blood*; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity; D015995:Prevalence; D000685:Serum Amyloid A Protein / Q000032:analysis; D012907:Smoking
D018836:Inflammation Mediators; D000685:Serum Amyloid A Protein; D005340:Fibrinogen; D002097:C-Reactive Protein