title: Management of non-union with pulsed low-intensity ultrasound therapy--international results.
abstract: In prospective, randomized, double-blind, placebo-controlled, multi-center clinical studies, pulsed, low-intensity ultrasound has been proven to be effective in decreasing the time to heal in both fresh diaphyseal (tibia) and metaphyseal (distal radius) fractures. It also decreases the likelihood of a delayed union (>150 days to heal) in tibia fractures and loss of reduction in distal radius fractures. World-wide clinical studies, using pulsed, low-intensity ultrasound for treatment of non-union in a self-paired control study design, have demonstrated a heal rate of 88% with an average treatment time of 4.5 months in non-unions and an average fracture age of 23 months. The therapy is safe and non-invasive, and is used by the patient at home for a 20-minute treatment session per day.
authors.affiliation: Hospital for Joint Diseases Orthopaedic Institute, New York, NY, USA.
authors.forename: Victor H
authors.initials: VH
authors.lastname: Frankel
authors.forename: Kosaku
authors.initials: K
authors.lastname: Mizuho
mesh_terms: D005599:Fractures, Ununited / Q000628:therapy*; D006801:Humans; D016896:Treatment Outcome; D014464:Ultrasonic Therapy