title: Cytogenetic analysis of 100 consecutive newly diagnosed cases of acute lymphoblastic leukemia in Rio de Janeiro.
abstract: We report the cytogenetic analysis of newly diagnosed Brazilian children with acute lymphocytic leukemia (ALL). We investigated 100 ALL cases from four different institutions in Rio de Janeiro. The frequency of chromosomal abnormalities was 92.3%. The karyotype profile and recurrent abnormalities found in this study do not differ essentially from those described by other groups. Although the Brazilian population is usually the product of different ethnic groups, our results show that the frequency of each recurrent abnormality is similar to that found in populations without our degree of diverse ethnic composition. Hence, our results suggest that childhood ALL in Brazil has the same biological features as that in developed countries, supporting the use of similar treatment protocols. We can therefore expect to reach the same survival rates in the coming years, depending possibly on the efficacy of the support therapy and extent of social assistance.
authors.affiliation: Laboratorio de Citogenetica, Centro de Transplante de Medula Ossea (CEMO), Instituto Nacional de Cancer (INCA), Praca Cruz Vermelha 23, 20 230-130 Rio de Janeiro, Brazil. luizamacedo@hotmail.com
authors.forename: Maria Luiza Macedo
authors.initials: ML
authors.lastname: Silva
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Ornellas de Souza
authors.forename: Raul C
authors.initials: RC
authors.lastname: Ribeiro
authors.forename: Marcelo Gerardin Poirot
authors.initials: MG
authors.lastname: Land
authors.forename: Alice Maria
authors.initials: AM
authors.lastname: Boulhosa de Azevedo
authors.forename: Felippe
authors.initials: F
authors.lastname: Vasconcelos
authors.forename: Luize
authors.initials: L
authors.lastname: Otero
authors.forename: Zilton
authors.initials: Z
authors.lastname: Vasconcelos
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Bouzas
authors.forename: Eliane
authors.initials: E
authors.lastname: Abdelhay
mesh_terms: D000293:Adolescent; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D011003:Ploidies; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology