title: Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6.
abstract: OBJECTIVE
  Cholesterolemic responses to dietary lipids are known to be heritable, but the genes that may affect this response have yet to be identified. Using segregation analysis, we previously detected a potential quantitative trait locus (QTL) in baboons that influenced low density lipoprotein cholesterol response to dietary cholesterol. We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map.
  
  
  RESULTS
  We obtained evidence for linkage of this potential QTL to the same locus (D6S311) on the baboon homologue of human chromosome 6 by using variance components and parametric linkage analysis methods (2-point lod scores 4.17 [genomic probability value 0.008] and 2.81 [genomic P=0.10], respectively). Linkage analyses of serum levels of apolipoprotein B dietary response, a correlated trait, also gave weak suggestive evidence of linkage to this chromosomal region (maximum 2-point lod score 1.91). Although the LPA locus is nearby, we found no evidence of linkage with LPA.
  
  
  CONCLUSIONS
  This report is the first to localize, in any primate species, a potential QTL that influences low density lipoprotein cholesterol response to dietary cholesterol.
authors.affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa 15261, USA. ckammerer@hgen.pitt.edu
authors.forename: Candace M
authors.initials: CM
authors.lastname: Kammerer
authors.forename: David L
authors.initials: DL
authors.lastname: Rainwater
authors.forename: Laura A
authors.initials: LA
authors.lastname: Cox
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Schneider
authors.forename: Michael C
authors.initials: MC
authors.lastname: Mahaney
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rogers
authors.forename: John L
authors.initials: JL
authors.lastname: VandeBerg
mesh_terms: D000818:Animals; D001055:Apolipoproteins B / Q000097:blood / Q000502:physiology; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood / Q000502:physiology*; D002874:Chromosome Mapping / Q000379:methods; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D005809:Genes, Regulator / Q000235:genetics / Q000502:physiology; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics* / Q000502:physiology*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D010215:Papio; D010375:Pedigree; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001055:Apolipoproteins B; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D005819:Genetic Markers