Sequence first. Ask questions later.
Comparative sequence analyses of eukaryotic genes and genomic regions are beginning to provide a wealth of information that is directly relevant to human biology. Functional changes that set us apart from apes are identifiable, as are functional constraints in proteins and genomic elements that arose in our relatively distant phylogenetic past.
Sidow
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Department of Pathology, SUMC R248B, 300 Pasteur Drive, Stanford University, Stanford, CA 94305, USA. arend@stanford.edu
D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D005823:Genetics; D016678:Genome; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D011323:Primates / Q000235:genetics; D017422:Sequence Analysis, DNA