title: CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons.
abstract: We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily. Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS. This gene is therefore implicated in CNS development, in particular in granule cell development.
authors.affiliation: Children's Brain Tumour Research Centre, Institute of Genetics, University of Nottingham, Queen's Medical Centre, UK.
authors.forename: Ching-Jung
authors.initials: CJ
authors.lastname: Lee
authors.forename: Wai-In
authors.initials: WI
authors.lastname: Chan
authors.forename: Martin
authors.initials: M
authors.lastname: Cheung
authors.forename: Yi-Chuan
authors.initials: YC
authors.lastname: Cheng
authors.forename: Vanessa J
authors.initials: VJ
authors.lastname: Appleby
authors.forename: Alex T
authors.initials: AT
authors.lastname: Orme
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Scotting
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D020224:Expressed Sequence Tags; D015723:Gene Library; D017344:Genes, Insect / Q000235:genetics; D006609:High Mobility Group Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009474:Neurons / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D014018:Tissue Distribution
chemical_list: C498610:CIC protein, human; C498611:Cic protein, mouse; D006609:High Mobility Group Proteins; D012097:Repressor Proteins