Alkaloids from Menispermum dauricum.
The alkaloids, dechloroacutumidine and 1-epidechloroacutumine, together with three known alkaloids, acutumidine, acutumine, and dechloroacutumine, were isolated from the rhizomes of Menispermum dauricum and their structures established by spectral and chemical methods. The cytotoxicity of each compound against the growth of human cell lines was studied, and acutumine selectively inhibited T-cell growth.
Yu
Bing-Wu
BW
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, People's Republic of China.
Chen
Jian-Yong
JY
Wang
Yan-Ping
YP
Cheng
Kin-Fin
KF
Li
Xiao-Yu
XY
Qin
Guo-Wei
GW
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001402:B-Lymphocytes / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D031603:Menispermum / Q000737:chemistry*; D015394:Molecular Structure; D009928:Organ Specificity; D027343:Rhizome / Q000737:chemistry; D013141:Spiro Compounds / Q000302:isolation & purification / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
C473531:1-epidechloroacutumine; D000470:Alkaloids; D013141:Spiro Compounds; C442344:acutumine; C473530:dechloroacutumidine