title: Pseudohyphal growth in a dimorphic yeast, Candida maltosa, after disruption of the C-GCN4 gene, a homolog of Saccharomyces cerevisiae GCN4.
abstract: The transcriptional activator protein Gcn4p increases the transcription of many genes that code for amino acid synthesis genes during amino acid starvation in Saccharomyces cerevisiae. Here we showed that after the disruption of C-GCN4, a homolog in Candida maltosa of GCN4 in S. cerevisiae, formed pseudohyphae in minimal medium. This is the first report that a GCN4 homolog is involved in the control of morphological transition.
authors.affiliation: Department of Biotechnology, University of Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takaku
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Horiuchi
authors.forename: Masamichi
authors.initials: M
authors.lastname: Takagi
authors.forename: Akinori
authors.initials: A
authors.lastname: Ohta
mesh_terms: D002175:Candida / Q000166:cytology / Q000235:genetics* / Q000254:growth & development*; D004268:DNA-Binding Proteins / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics*; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D013997:Time Factors; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D012331:RNA, Fungal; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases