The pharmacokinetics, safety and tolerability of the co-administration of diethylcarbamazine and albendazole.
The pharmacokinetics, safety and tolerability of single, oral doses of diethylcarbamazine (DEC) and albendazole, given alone or in combination, were investigated in a double-blind, randomized and placebo-controlled trial involving 42 amicrofilaraemic subjects living in an area of India where lymphatic filariasis is endemic. The subjects (34 males and eight females, aged 18-52 years and weighing 46-66.5 kg) were randomly allocated to one of the three drug groups. Fourteen were given just DEC (6 mg/kg), another 14 were given just albendazole (400 mg) and the remaining 14 were given both DEC (6 mg/kg) and albendazole (400 mg). Blood samples for pharmacokinetic study were collected at specified intervals before and after drug administration. Plasma concentrations of DEC and albendazole/albendazole sulphoxide were estimated using gas chromatography and HPLC, respectively. The safety and tolerability of the treatments were evaluated through clinical and laboratory assessments. Both the DEC and albendazole were well tolerated when given alone or in combination, no adverse events being observed. In all three treatment groups, the drugs were rapidly absorbed from the gastro-intestinal tract although there was marked inter-individual#10; variation. The pharmacokinetics of DEC, albendazole and albendazole sulphoxide were similar, whether each drug was given alone or in combination. These results indicate that there is no adverse pharmacokinetic or pharmacodynamic reason why DEC and albendazole should not be co-administered to control lymphatic filariasis.
Shenoy
R K
RK
Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha - 688 011, India. rkshenoy2000@yahoo.com
Suma
T K
TK
John
A
A
Arun
S R
SR
Kumaraswami
V
V
Fleckenstein
L L
LL
Na-Bangchang
K
K
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D015766:Albendazole / Q000009:adverse effects / Q000097:blood*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004049:Diethylcarbamazine / Q000009:adverse effects / Q000097:blood*; D004311:Double-Blind Method; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004605:Elephantiasis, Filarial / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005369:Filaricides / Q000009:adverse effects / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005369:Filaricides; D015766:Albendazole; D004049:Diethylcarbamazine