title: Presynaptic hyperexcitability at cerebellar synapses in traumatic injury rat.
abstract: Neurotransmission in rat cerebellum following fluid percussion injury (FPI) was studied by extracellular recording method. An increased amplitude of population spikes from presynaptic mossy fibers was detected at 3 days after FPI. However, there were no differences at 1 h, 1 day, 1 week or 2 weeks after FPI compared to nai;ve controls. An enhanced amplitude of the population spikes, as well as the after hyperpolarization component from presynaptic response of the parallel fibers, was seen in the groups at 3 days and 1 week post FPI, but not in other groups. These results indicate a presynaptic hyperexcitation was induced by FPI within a specific time window. This hyperexcitability may contribute to the reported loss of Purkinje cells after FPI.
authors.affiliation: Trauma Brain Injury Laboratory, Cara Phelan Center for Trauma Research, St Michael's Hospital, University of Toronto, Toronto, Ont M5B 1W8, Canada. aij@smh.toronto.on.ca
authors.forename: Jinglu
authors.initials: J
authors.lastname: Ai
authors.forename: Andrew
authors.initials: A
authors.lastname: Baker
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology*; D004558:Electric Stimulation; D004594:Electrophysiology; D008297:Male; D019599:Mossy Fibers, Hippocampal / Q000473:pathology; D011689:Purkinje Cells / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017661:Receptors, Presynaptic / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D017661:Receptors, Presynaptic