Synthesis of series of 1- and 3-differently substituted xanthines from imidazoles.
A new and general method is described for the synthesis, in three steps and in good overall yields, of tetrasubstituted xanthines from an easily prepared imidazole precursor. The method is especially useful for the preparation in standardized conditions of series of xanthines combining a broad variety of primary or secondary alkyl, benzyl or aryl groups at N1 and of alkyl or arylmethyl groups at N3, that are not readily available by other methods.
Hergueta
Antonio Rodríguez
AR
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, Spain.
Figueira
María José
MJ
López
Carmen
C
Caamaño
Olga
O
Fernández
Franco
F
Rodríguez-Borges
José Enrique
JE
D007093:Imidazoles / Q000737:chemistry*; D014970:Xanthines / Q000138:chemical synthesis* / Q000737:chemistry
D007093:Imidazoles; D014970:Xanthines