Primary mucosa-associated lymphoid tissue (MALT) lymphoma arising from the male urethra. A case report and review of the literature.
Primary non-Hodgkin's lymphomas rarely arise from the lower urinary tract, the urethra being the most uncommon site of origin. Herein, we report the immunohistochemical findings of a case of primary marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arising from the male urethra. To clarify the clinicopathological findings of primary urethral lymphoma, we reviewed 14 previously reported cases. A 56-year-old man presented with gross hematuria. Cystourethroscopy demonstrated a nodular bulge of the urethral wall. Histologically, a transurethral biopsy specimen showed a dense lymphoplasmacytoid infiltrate in the urethral mucosa. The tumor cells were composed of centrocyte-like cells, plasma cells and plasmacytoid cells. A few plasma cells contained intracytoplasmic pseudoinclusions (Dutcher bodies). Immunohistochemical study revealed monotypic intracytoplasmic kappa-light chain in the plasma cells and plasmacytoid cells. The patient received a total of 50 Gy extrabeam irradiation. Follow-up 21 months later did not disclose any sign of local or other recurrences.
Masuda
Akinori
A
Department of Urology, Dokkyo University School of Medicine, Tochigi, Japan.
Tsujii
Toshihiko
T
Kojima
Masaru
M
Sakamoto
Shu-ichi
S
Moriguchi
Hideo
H
Honda
Mikihiko
M
Yoshida
Ken-ichiro
K
D003558:Cystoscopy; D003593:Cytoplasm / Q000378:metabolism; D004724:Endoscopy; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014523:Urethral Neoplasms / Q000378:metabolism / Q000473:pathology*
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains