Triterpenoids from the leaves of Psidium guajava.
Two triterpenoids, 20beta-acetoxy-2alpha,3beta-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2alpha,3beta-dihydroxy-24-p-z-coumaroyloxyurs-12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2alpha-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and beta-sitosterol-3-O-beta-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 microg/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations.
Begum
Sabira
S
H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. sabira@khi.comsaats.net.pk
Hassan
Syed Imran
SI
Siddiqui
Bina S
BS
Shaheen
Farhana
F
Ghayur
M Nabeel
MN
Gilani
Anwar H
AH
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D031647:Psidium / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*
D014315:Triterpenes; C473527:guavacoumaric acid; C473526:guavanoic acid