title: Particle size and morphology of UHMWPE wear debris in failed total knee arthroplasties--a comparison between mobile bearing and fixed bearing knees.
abstract: Osteolysis induced by ultrahigh molecular weight polyethylene wear debris has been recognized as the major cause of long-term failure in total joint arthroplasties. In a previous study, the prevalence of intraoperatively identified osteolysis during primary revision surgery was much higher in mobile bearing knee replacements (47%) than in fixed bearing knee replacements (13%). We postulated that mobile bearing knee implants tend to produce smaller sized particles. In our current study, we compared the particle size and morphology of polyethylene wear debris between failed mobile bearing and fixed bearing knees. Tissue specimens from interfacial and lytic regions were extracted during revision surgery of 10 mobile bearing knees (all of the low contact stress (LCS) design) and 17 fixed bearing knees (10 of the porous-coated anatomic (PCA) and 7 of the Miller/Galante design). Polyethylene particles were isolated from the tissue specimens and examined using both scanning electron microscopy and light-scattering analyses. The LCS mobile bearing knees produced smaller particulate debris (mean equivalent spherical diameter: 0.58 microm in LCS, 1.17 microm in PCA and 5.23 microm in M/G) and more granular debris (mean value: 93% in LCS, 77% in PCA and 15% in M/G).
authors.affiliation: Department of Orthopaedic Surgery, Mackay Memorial Hospital, Taipei, Taiwan. chhuang@ms2.mmh.org.tw
authors.forename: Chun-Hsiung
authors.initials: CH
authors.lastname: Huang
authors.forename: Fang-Yuan
authors.initials: FY
authors.lastname: Ho
authors.forename: Hon-Ming
authors.initials: HM
authors.lastname: Ma
authors.forename: Chan-Tsung
authors.initials: CT
authors.lastname: Yang
authors.forename: Jiann-Jong
authors.initials: JJ
authors.lastname: Liau
authors.forename: Hung-Chan
authors.initials: HC
authors.lastname: Kao
authors.forename: Tai-Horng
authors.initials: TH
authors.lastname: Young
authors.forename: Cheng-Kung
authors.initials: CK
authors.lastname: Cheng
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001672:Biocompatible Materials / Q000145:classification; D005260:Female; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010316:Particle Size; D011095:Polyethylenes / Q000145:classification; D011474:Prosthesis Design; D011475:Prosthesis Failure
chemical_list: D001672:Biocompatible Materials; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene