Recognition of acetylated proteins: lessons from an ancient family of enzymes.
The structure of a Sir2-like enzyme in complex with an acetylated peptide substrate has been solved, and provides the first glimpse into the mechanism of substrate recognition by this highly conserved family of enzymes.
Tanny
Jason C
JC
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Moazed
Danesh
D
D000107:Acetylation; D018360:Crystallography, X-Ray; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D004798:Enzymes; D011506:Proteins