Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity.
These studies show that either central pharmacological blockade or genetic ablation of alpha(1B)-adrenoceptors markedly attenuates the behavioral activation caused by modafinil, implicating these receptors in the drug's action.
Stone
Eric A
EA
New York University School of Medicine, New York, New York 10016, USA. es35@nyu.edu
Cotecchia
Susanna
S
Lin
Yan
Y
Quartermain
David
D
D018674:Adrenergic Antagonists / Q000494:pharmacology; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000077408:Modafinil; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D018340:Receptors, Adrenergic, alpha-1 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
C547717:Adra1b protein, mouse; D018674:Adrenergic Antagonists; D001559:Benzhydryl Compounds; D018340:Receptors, Adrenergic, alpha-1; D000077408:Modafinil