Case report: Survival after deliberate strychnine self-poisoning, with toxicokinetic data.
BACKGROUND
Strychnine poisoning is uncommon, and in most severe cases, the patient dies before reaching hospital. The management of strychnine poisoning is well documented, although there are few data on the kinetics of elimination of strychnine after overdose.


METHODS
A 42-year-old man presented shortly after ingestion of an unknown quantity of strychnine powder. After a respiratory arrest, with intensive supportive management requiring admission to an intensive care unit, he survived. Eight serum samples were taken over the first 5 days and analysed subsequently for strychnine concentrations.


RESULTS
The initial concentration at 1.5 hours after ingestion was 4.73 mg/l, falling to 0.38 mg/l at 74 hours postingestion. Serum concentrations followed a monoexponential elimination curve with a calculated elimination half-life of 12 hours.


CONCLUSIONS
Strychnine poisoning presents with classical features, and with early diagnosis and supportive management, the patient can survive. The initial serum concentration of 4.73 mg/l is the highest reported concentration in a patient who has survived. Previous reports of the elimination half-life have suggested it is between 10 and 16 hours, which conforms to the elimination data in our case.
Wood
David
D
National Poisons Information Service, Guy's and St Thomas' Hospital, London, UK. grex1@hotmail.com
Webster
Emma
E
Martinez
Daniel
D
Dargan
Paul
P
Jones
Alison
A
D000328:Adult; D003422:Critical Care; D006207:Half-Life; D006801:Humans; D008297:Male; D011041:Poisoning / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D013331:Strychnine / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D016896:Treatment Outcome
D013331:Strychnine