title: Understanding the physiological and functional consequences of menopause: the PROSALMEN study. PROgetto SALute MENopausa.
abstract: OBJECTIVE
  Women live longer and are more often affected by disability and poor health than men. The mechanism underlying this sex-related "mortality-morbidity" paradox is still unclear but it has been suggested that the physiological and functional changes occurring during the menopausal transition play an important role. The aim of PROSALMEN (PROgetto SALute MENopausa: Health in Menopause Project) is to study in great detail how these changes affect the integrity and function of the physiologic subsystems that are relevant to the maintenance of an active and healthy life-style during the aging process.
  
  
  METHODS
  PROSALMEN is a cross-sectional comparison of age-matched pre- and post-menopausal women. Thirty post-menopausal women, aged 48-58 years, were enrolled in the study together with 30 age-matched pre-menopausal controls. A number of clinical, biological and functional parameters were collected assessing the integrity and level of function of the physiological subsystems that are important for mobility. Furthermore, we collected information on risk factors, medical conditions and symptoms that frequently develop or become clinically evident after menopause, including the most important elements of the classical post-menopausal syndrome.
  
  
  CONCLUSIONS
  This rich dataset will be used to start dissecting the causal pathway leading from menopause to damages in the musculoskeletal system and, in turn, to reduced physical function. The final goal is to understand how and to what extent changes in health behavior and pharmacological treatments in addition to hormone replacement therapy (HRT) may counteract these processes.
authors.affiliation: INRCA Geriatric Department, Firenze, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Fulvio
authors.initials: F
authors.lastname: Lauretani
authors.forename: Enrico
authors.initials: E
authors.lastname: Benvenuti
authors.forename: Annamaria
authors.initials: A
authors.lastname: Corsi
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: De Marco
authors.forename: Benedetta
authors.initials: B
authors.lastname: Bartali
authors.forename: Giacomo
authors.initials: G
authors.lastname: Ruotolo
authors.forename: Benedetta
authors.initials: B
authors.lastname: Miniati
authors.forename: Claudio
authors.initials: C
authors.lastname: Macchi
authors.forename: Cosimo R
authors.initials: CR
authors.lastname: Russo
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000375:Aging / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008019:Life Style; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology