Benzotrithiole 2-oxide: a new family of thiol-activated DNA-cleaving functionalities.
It was demonstrated in our studies that benzotrithiole 2-oxide was capable of causing efficient DNA cleavage in the presence of 2-mercaptoethanol or glutathione and exhibited potent cytotoxic properties against certain cancer cell lines.
Lee
Alex H F
AH
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
Chan
Albert S C
AS
Li
Tianhu
T
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005978:Glutathione; D006801:Humans; D006868:Hydrolysis / Q000187:drug effects; D008623:Mercaptoethanol; D010087:Oxides / Q000494:pharmacology*; D010957:Plasmids / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010087:Oxides; D013438:Sulfhydryl Compounds; C475579:benzotrithiole 2-oxide; D008623:Mercaptoethanol; D004247:DNA; D005978:Glutathione