[Current status of study on selective cyclooxygenase-2 inhibitors and evaluation of its application].
Selective cyclooxygenase-2 inhibitors have anti-inflammatory efficacy and can reduce the side effects and toxicity induced by inhibition of cyclooxygenase-1, thus can be widely used in clinical practice. However, the adverse effects of these drugs should be given their due attention. Currently, looking for better selective cyclooxygenase-2 inhibitors has become a hot topic in developing the non-steroidal anti-inflammatory drugs.
He
Wei
W
Department of Pharmacy, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Liu
Chu-Feng
CF
Huang
Chang-Quan
CQ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases