title: Comparison of tc-99m depreotide and in-111 octreotide in recurrent meningioma.
abstract: OBJECTIVE
  For more than a decade, In-111 octreotide has been known to accumulate in meningiomas as a result of the expression of subtype 2 somatostatin receptors. Improved imaging characteristics can be expected with the recently developed radiotracer Tc-99m depreotide, which also binds to subtype 2 somatostatin receptors.
  
  
  METHODS
  The authors examined a patient with intraorbital and extracranial recurrent meningioma using SPECT with Tc-99m depreotide and In-111 octreotide. The tumor-to-background ratios in the lesions were compared and the findings were correlated with histopathologic findings.
  
  
  RESULTS
  Although the tumor-to-background ratios were higher for the In-111-labeled tracer in the largest tumor lesion (5.7 versus 3.3), SPECT with the Tc-99m-labeled compound showed a proved second site of recurrence as a result of the better resolution that can be achieved with that isotope. CONCLUSIONS SPECT: with Tc-99m depreotide appears to be clinically useful for detecting recurrent meningiomas with higher resolution and may outperform In-111 octreotide imaging in patients with meningiomas.
authors.affiliation: Department of Nuclear Medicine, Saarland University Medical School, Homburg-Saar, Germany. Dirk.Hellwig@uniklinik-saarland.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Hellwig
authors.forename: Samuel
authors.initials: S
authors.lastname: Samnick
authors.forename: Johannes
authors.initials: J
authors.lastname: Reif
authors.forename: Bernd F M
authors.initials: BF
authors.lastname: Romeike
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Reith
authors.forename: Jean R
authors.initials: JR
authors.lastname: Moringlane
authors.forename: Carl-Martin
authors.initials: CM
authors.lastname: Kirsch
mesh_terms: D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013004:Somatostatin / Q000031:analogs & derivatives*
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C094279:indium-111-octreotide; D013004:Somatostatin; C444119:technetium Tc 99m depreotide; D015282:Octreotide