Chaperones come of age.
Chaperone function plays a key role in repairing proteotoxic damage, in the maintenance of cell architecture, and in cell survival. Here, we summarize our current knowledge about changes in chaperone expression and function in the aging process, as well as their involvement in longevity and cellular senescence.
Soti
Csaba
C
Department of Medical Chemistry, Semmelweis University, Budapest, Hungary.
Csermely
Péter
P
D000375:Aging / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology*; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000502:physiology
D018832:Molecular Chaperones; D011506:Proteins