title: Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy.
abstract: Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis of unknown etiology and pathogenesis. Immunogenetic studies have not conclusively indicated that human leukocyte antigen (HLA) is involved. As a first step in investigating a possible relationship between HLA class II genes and IgAN, we analyzed the extent of linkage disequilibrium (LD) in this region of chromosome 6p21.3 in a Japanese test population and found extended LD blocks within the class II locus. We designed a case-control association study of single-nucleotide polymorphisms (SNPs) in each of those LD blocks, and determined that SNPs located in the HLA- DRA gene were significantly associated with an increased risk of IgAN ( P = 0.000001, odds ratio = 1.91 [95% confidence interval 1.46-2.49]); SNPs in other LD blocks were not. Our data imply that some haplotype of the HLA- DRA locus has an important role in the development of IgAN in Japanese patients.
authors.affiliation: Human Genome Center, The Institute of Medical Science, University of Tokyo, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Akiyama
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamada
authors.forename: Yozo
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Shiro
authors.initials: S
authors.lastname: Maeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Takei
authors.forename: Wataru
authors.initials: W
authors.lastname: Obara
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ito
authors.forename: Kazuho
authors.initials: K
authors.lastname: Honda
authors.forename: Keiko
authors.initials: K
authors.lastname: Uchida
authors.forename: Ken
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nihei
authors.forename: Takashi
authors.initials: T
authors.lastname: Ujiie
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagane
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyano
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujioka
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059805:HLA-DR alpha-Chains; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D006684:HLA-DR Antigens; D059805:HLA-DR alpha-Chains