Ethnicity and type 2 diabetes in Rio de Janeiro, Brazil, with a review of the prevalence of the disease in Amerindians.
To what extent can ethnic factors contribute to the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in an urban Brazilian population? Conversely, how can environmental factors such as diet change these prevalences in a given ethnic group, in this case Brazilian Indians? To answer these questions estimates of ethnic admixture in Afro- and Euro-Brazilians from Rio de Janeiro, Brazil, were established using eight genetic systems and compared with the prevalences of these conditions obtained previously. This information was integrated with results obtained inside and outside of Brazil. The similarity of prevalences for type 2 diabetes and IGT in Afro- and Euro-Brazilians may be related to the extensive gene flow that occurred between them and to similar socioeconomic levels in the samples investigated. On the other hand, changes in the traditional diet are probably conditioning the appearance of diabetes among Brazilian and other South American Indians.
Palatnik
Marcos
M
Departamento de Clínica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil.
da Silva Júnior
Wilson Araújo
WA
Estalote
Angela Cristina
AC
de Oliveira
José Egidio Paulo
JE
Milech
Adolpho
A
Zago
Marco Antonio
MA
D000483:Alleles; D001782:Blood Donors; D001938:Brazil / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology*; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005951:Glucose Tolerance Test; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008297:Male; D015995:Prevalence; D014505:Urban Population