title: A comparison of murine and human immunoproteomes of Helicobacter pylori validates the preclinical murine infection model for antigen screening.
abstract: Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter pylori immunoproteomes of infected mice with previously reported patient data reveals a high agreement in the antigens recognized, suggesting that H. pylori in vivo protein composition and recognition by the host immune system are comparable in mice and humans. Murine Helicobacter models may thus be valid to screen antigens for human vaccination.
authors.affiliation: Department of Molecular Biology, Max-Planck-Institute for Infection Biology, Berlin, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Bumann
authors.forename: Petra
authors.initials: P
authors.lastname: Holland
authors.forename: Frank
authors.initials: F
authors.lastname: Siejak
authors.forename: Jan
authors.initials: J
authors.lastname: Koesling
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sabarth
authors.forename: Stefanie
authors.initials: S
authors.lastname: Lamer
authors.forename: Ursula
authors.initials: U
authors.lastname: Zimny-Arndt
authors.forename: Peter R
authors.initials: PR
authors.lastname: Jungblut
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Meyer
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis* / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D020543:Proteome
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D020543:Proteome