A rare, in-frame BCR-ABL fusion (e13a3) in a patient with an aggressive chronic myeloid leukaemia.
We have identified a rare BCR-ABL chimaeric gene with multiplex and nested RT-PCR in a patient with an unusually aggressive chronic myeloid leukaemia. cDNA sequencing showed an in-frame rearrangement with a breakpoint in BCR exon e13 (b2) and fusion with ABL exon 3 following skipping of the entire ABL exon a2. These data confirm the heterogeneity of breakpoints in BCR-ABL rearrangements.
Otazú
Ivone B
IB
Division de Genética, Instituto Nacional de Câncer, Universidade Federal do Rio de Janeiro, Brazil. genetics@inca.org.broriotazu@ufrj.br
Belén Rivero
María
M
Olício
Renata
R
Pinto
Augusto
A
Zalcberg
Ilana
I
Seuánez
Héctor N
HN
D000328:Adult; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
D016044:Fusion Proteins, bcr-abl