title: Copper-catalyzed arylation of beta-amino alcohols.
abstract: [reaction: see text] Methods for synthesizing N-aryl beta-amino alcohols and O-aryl beta-amino alcohols are described. The presence of a neighboring hydroxyl or amino group, respectively, is thought to activate beta-amino alcohols toward these transformations. These protocols significantly increase access to a variety of arylated beta-amino alcohols.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Gabriel E
authors.initials: GE
authors.lastname: Job
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*
chemical_list: D000605:Amino Alcohols; D003300:Copper