[Effects of Buyanghuanwu decoction (BYHWT) on proliferation of cultured rat cortical neurons].
OBJECTIVE
To observe the effect of rat serum containing Buyanghuanwu decoction (BYHWT) on the proliferation of cultured rat cortical neurons, so as to understand the mechanism of BYHWT in the treatment of hypoxia brain damage.


METHODS
The growth of cultured rat cortical neurons were observed by MTT assay to evaluate the effect of the serum containing BYHWT on the neurons cultured in both normal and hypoxia conditions.


RESULTS
BYHWT significantly promoted proliferation of the neurons cultured under both normal and hypoxia conditions, in comparison with the response of the cells to drug-free serum (P<0.05).


CONCLUSIONS
Some of the constituents of BYHWT in rat serum can promote the proliferation of rat cortical neurons cultured in both normal and hypoxia conditions.
Tong
Li
L
Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China.
Qu
Hong-Da
HD
Chen
Yu-Yao
YY
Shen
Jian-Gang
JG
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D015687:Cell Hypoxia; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; C460102:buyang huanwu