title: Nerve membrane ion channels as the target site of insecticides.
abstract: Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly on sodium channels to keep them open leading to hyperexcitation. Indoxacarb inhibits sodium channels and certain subtypes of nicotinic receptors. Dieldrin, lindane and fipronil block GABA receptors. Imidacloprid modulates nicotinic receptors in a complex manner. Spinosad's major target site appears to be nicotinic receptors.
authors.affiliation: Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL 60611, USA. tna597@nwu.edu
authors.forename: Toshio
authors.initials: T
authors.lastname: Narahashi
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D007306:Insecticides / Q000494:pharmacology* / Q000633:toxicity; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D007306:Insecticides; D007473:Ion Channels