title: Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.
abstract: Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.
authors.affiliation: Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston South Carolina 29425, USA. bakerda@musc.edu
authors.forename: D A
authors.initials: DA
authors.lastname: Baker
authors.forename: H
authors.initials: H
authors.lastname: Shen
authors.forename: P W
authors.initials: PW
authors.lastname: Kalivas
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003553:Cystine / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism*; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology; D020960:omega-Conotoxins / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D018765:Dopamine Uptake Inhibitors; D020960:omega-Conotoxins; D018698:Glutamic Acid; D013779:Tetrodotoxin; D003553:Cystine; D004110:Diltiazem; D003042:Cocaine