Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver.
According to the free radical theory of aging, oxygen-derived free radicals causes the age-associated impairment at the cellular and tissue levels. The mitochondrial theory of aging points to mitochondria, and specially mitochondrial DNA, as the major targets of free radical attack upon aging. Thus, oxidative damage to mtDNA accumulate with age in human and rodent tissues and also is inversely related to maximum life span of mammals. Mitochondrial deficits, such as a decrease in mitochondrial membrane potential, occur upon aging due to oxidative damage. The age-related mitochondrial oxidative stress may be prevented by late onset administration of certain antioxidants, such as Ginkgo biloba extract EGb 761. These antioxidants may also delay the physiological impairment associated with aging.
Sastre
Juan
J
Departamento de Fisiologia, Facultad de Medicina, Universitat de València, Spain. juan.sastre@uv.es
Lloret
Ana
A
Borrás
Consuelo
C
Pereda
Javier
J
García-Sala
David
D
Droy-Lefaix
Marie-Thérèse
MT
Pallardó
Federico V
FV
Viña
José
J
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004249:DNA Damage / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism; D020441:Ginkgo biloba; D008928:Mitochondria / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D000096983:Ginkgo Extract
D000975:Antioxidants; D005609:Free Radicals; D018696:Neuroprotective Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract