title: Comparison of oligosaccharides derived from salivary mucin of Japanese secretor and non-secretor individuals of blood group type-A.
abstract: Comparison of oligosaccharide components derived from salivary mucin was performed between secretor and non-secretor individuals. Salivary mucin was collected from four secretors and three non-secretors having blood group type-A. Compositional analysis showed that the contents of galactose and N-acetylglucosamine in the non-secretor were higher than those in the secretor. The O-linked oligosaccharides obtained by treatment with alkaline borohydride were separated by gel filtration using Sephadex G-50. The results indicated that the size of the type-A active oligosaccharides from the secretor was similar to or smaller than that of the non-secretor. Ion-exchange chromatography showed that the secretors had strong type-A activities in both the neutral and acidic fractions but the non-secretors showed type-A activity mainly in the neutral fraction. These results suggest that compositional differences in blood group substances exist between secretors and non-secretors.
authors.affiliation: National Research Institute of Police Science, 6-3-1, Kashiwa-no-ha, Kashiwa, Chiba, 277-0882, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohmori
authors.forename: H
authors.initials: H
authors.lastname: Toyoda
authors.forename: T
authors.initials: T
authors.lastname: Toida
authors.forename: T
authors.initials: T
authors.lastname: Imanari
authors.forename: H
authors.initials: H
authors.lastname: Sato
mesh_terms: D000017:ABO Blood-Group System; D000606:Amino Sugars / Q000032:analysis / Q000737:chemistry; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007564:Japan; D007983:Lewis Blood Group Antigens; D009005:Monosaccharides / Q000032:analysis / Q000737:chemistry; D009077:Mucins / Q000737:chemistry* / Q000302:isolation & purification; D009844:Oligosaccharides / Q000032:analysis / Q000737:chemistry*; D010641:Phenotype; D012463:Saliva / Q000378:metabolism*
chemical_list: D000017:ABO Blood-Group System; D000606:Amino Sugars; D007983:Lewis Blood Group Antigens; D009005:Monosaccharides; D009077:Mucins; D009844:Oligosaccharides