Restless legs syndrome and periodic limb movements of sleep: fact, fad, and fiction.
Restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) are common disorders seen in sleep disorder centers. Although RLS in universally thought to cause daytime sleepiness, the role of PLMS in causing sleepiness (or any symptom!) has been more controversial. Recent publications have show that PLMS do not cause either subjective or objective sleepiness, but may be a marker for respiratory effort related arousals. In regards to patients with end-stage renal disease, PLMS may mark mortality. In this same group of patients, gabapentin and normalization of hematocrit may be effective therapies for RLS/PLMS. Melatonin may prove to be an alternative therapy for PLMS.
Patel
Sanjiv
S
Division of Pulmonary and Critical Care Medicine, University of Kentucky College of Medicine, Lexington, USA. spatel329@aol.com
D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000628:therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D006801:Humans; D008550:Melatonin / Q000627:therapeutic use; D020189:Nocturnal Myoclonus Syndrome / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D051437:Renal Insufficiency / Q000150:complications / Q000628:therapy; D012148:Restless Legs Syndrome / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D012307:Risk Factors
D000927:Anticonvulsants; D008550:Melatonin