title: Enhanced weight gain in preterm infants receiving lactase-treated feeds: a randomized, double-blind, controlled trial.
abstract: OBJECTIVE
  To evaluate whether lactase-treated preterm feeds enhance weight gain and feeding tolerance in premature infants.
  
  
  METHODS
  Prospective, double-blind, randomized, controlled trial involving 130 infants (26-34 weeks postconceptual age). The primary outcome variable was weight gain (g per day). Other outcome measures included gains in length and head circumference, biochemical indexes of nutritional status, feeding intolerance, and incidence of necrotizing enterocolitis.
  
  
  RESULTS
  On study day 10, weight gain (mean +/- SEM) of the treatment group was significantly greater (P <.05) than that of the control group (20.4 +/- 1.8 g/day vs 15.5 +/- 1.6 g/day). By study end, no significant difference in weight gain between treatment and control groups was observed. The difference in serum albumin level was significant at study day 14, with a value of 29.3 +/- 0.6 g/L in the treatment group compared with 27.1 +/- 0.4 g/L in the control group (P <.01). There were no significant differences in caloric intakes, length gain, head circumference gain, feeding intolerance, and incidence of necrotizing enterocolitis.
  
  
  CONCLUSIONS
  Weight gain may be enhanced during the period of low functional lactase activity of prematurity by addition of lactase to preterm feeds. No adverse effects on feeding tolerance resulted from this treatment.
authors.affiliation: Department of Nutrition Services and Neonatal Intensive Care Unit, Royal University Hospital, and the College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Helen D
authors.initials: HD
authors.lastname: Erasmus
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Ludwig-Auser
authors.forename: Phyllis G
authors.initials: PG
authors.lastname: Paterson
authors.forename: Dongmei
authors.initials: D
authors.lastname: Sun
authors.forename: Koravangattu
authors.initials: K
authors.lastname: Sankaran
mesh_terms: D001903:Bottle Feeding; D004311:Double-Blind Method; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology; D007229:Infant Welfare; D007231:Infant, Newborn / Q000254:growth & development; D007234:Infant, Premature / Q000254:growth & development*; D043322:Lactase; D009752:Nutritional Status / Q000502:physiology; D011446:Prospective Studies; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects*; D001616:beta-Galactosidase / Q000627:therapeutic use*
chemical_list: D012709:Serum Albumin; D043322:Lactase; D001616:beta-Galactosidase