[Seizure inhibition by vagal nerve stimulation in rats].
OBJECTIVE
To study the effect of vagal nerve stimulation in seizure inhibition in rats.


METHODS
In rat epileptic models induced by penicillin, electromyogram (EMG), electroencephalogram (EEG) and extracellular electric activity of the cortex were recorded to study the inhibiting effect of vagal nerve stimulation on epilepsy. Results Inhibiting effect of vagal nerve stimulation on epilepsy was observed from the changes in behavior, EMG, EEG and extracellular electric activity of the rats, and this inhibiting effect was enhanced as the frequency for stimulation increased from 5 Hz to 20 Hz. Conclusion Vagal nerve stimulation can inhibit the epileptic activity in rats, the effect of which depends on the stimulation conditions imposed on the rats.
Yang
Hong-Jun
HJ
Department of Neurology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010 China. yanghongjun6666@yahoo.com.cn
Hu
San-Jue
SJ
D000818:Animals; D001016:Aortic Bodies / Q000473:pathology*; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods; D004599:Electric Stimulation Therapy; D005260:Female; D008297:Male; D009417:Nerve Tissue / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000628:therapy*