title: Detection of human herpes virus type 6 DNA in precancerous lesions of the uterine cervix.
abstract: Human herpes virus type 6 (HHV-6) DNA has been suggested to be a cofactor to human papillomavirus (HPV) in cervical cancer. In a cross-sectional study, we investigated the association between HHV-6 DNA detected in cervical brushings and high-grade squamous intraepithelial lesions (HSIL), while controlling for genital infection with 27 genotypes of HPV. Of the 320 women recruited from an oncologic gynecology clinic, 50 had invasive cervical cancer, 65 had HSIL, 80 had low-grade squamous intraepithelial lesions (LSIL), and 125 were normal. Four of the seven HHV-6-positive women had HSIL. HHV-6 was associated with HSIL after adjusting for age and socioeconomic status (odds ratio [OR] of 10.9, 95% confidence interval [CI]: 1.1-107.1). This association was no longer significant after controlling for HPV (OR = 6.4, 95% CI = 0.3-128.5). HHV-6 was detected in cervical samples from women with precancerous and cancerous lesions of the cervix, but not significantly more frequently than in normal women.
authors.affiliation: Départements de Microbiologie Médicale et Infectiologie, Gynécologie-Obstétrique et Pathologie, Université de Montréal, Montréal, Qué., Canada.
authors.forename: Danh
authors.initials: D
authors.lastname: Tran-Thanh
authors.forename: Anita
authors.initials: A
authors.lastname: Koushik
authors.forename: Diane
authors.initials: D
authors.lastname: Provencher
authors.forename: Pierre
authors.initials: P
authors.lastname: Drouin
authors.forename: Josée
authors.initials: J
authors.lastname: Dubuc-Lissoir
authors.forename: Philippe
authors.initials: P
authors.lastname: Gauthier
authors.forename: Guy
authors.initials: G
authors.lastname: Allaire
authors.forename: Janet
authors.initials: J
authors.lastname: Kornegay
authors.forename: Eduardo
authors.initials: E
authors.lastname: Franco
authors.forename: François
authors.initials: F
authors.lastname: Coutlée
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005838:Genotype; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D011230:Precancerous Conditions; D012307:Risk Factors; D019349:Roseolovirus Infections / Q000821:virology*; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000821:virology*; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral