title: Leptin levels are appropriate for body mass index in older men who experience involuntary weight loss.
abstract: OBJECTIVE
  To determine the relationship between leptin and unintentional weight loss in older adults.
  
  
  METHODS
  Prospective cohort study over 2 years.
  
  
  METHODS
  University-affiliated Veterans Affairs Medical Center.
  
  
  METHODS
  The subjects were 105 community-dwelling male veterans aged 65 and older who had participated in a prospective cohort study on nutrition and health conducted at the Veterans Affairs Puget Sound Health Care System from 1986 to 1989.
  
  
  METHODS
  Anthropometric data and fasting blood specimens were collected at baseline and annually for the subsequent 2 years. Stored blood specimens were analyzed for leptin, insulin, glucose, C-reactive protein, sex hormone binding globulin, and testosterone levels.
  
  
  RESULTS
  Over 2 years, 75 men were weight stable (weight loss <4% of baseline) and 30 men had unintentional weight loss (weight loss>4% of baseline). The baseline body mass index (BMI) and leptin levels for the two groups were not statistically different. Positive correlations existed between leptin level and BMI at each time point for weight-stable and weight-loss subjects. Furthermore, a significant relationship existed between changes in leptin and changes in BMI over 1 year in multiple regression analysis (r =.436, P <.001 after the first year; and r =.630, P =.027 after the second year).
  
  
  CONCLUSIONS
  Like in younger adults, plasma leptin levels remained proportional to BMI, and changes in BMI were accurately reflected by changes in leptin levels in older individuals. Fasting leptin levels did not predict involuntary weight loss over 2 years of follow-up.
authors.affiliation: Divisions of Gerontology and Geriatric Medicine and Endocrinology, University of Washington, Seattle, Washington 98104, USA. myukawa@u.wahington.edu
authors.forename: Michi
authors.initials: M
authors.lastname: Yukawa
authors.forename: Wayne C
authors.initials: WC
authors.lastname: McCormick
authors.forename: Suparna
authors.initials: S
authors.lastname: Rajan
authors.forename: Alvin M
authors.initials: AM
authors.lastname: Matsumoto
authors.forename: Jeffery I
authors.initials: JI
authors.lastname: Wallace
authors.forename: Robert A
authors.initials: RA
authors.lastname: Pearlman
authors.forename: David S
authors.initials: DS
authors.lastname: Weigle
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D002097:C-Reactive Protein