title: Amlodipine versus Angiotensin-receptor blockers for nonhypertension indications.
abstract: OBJECTIVE
  To review the efficacy and safety data of amlodipine and the angiotensin-receptor blockers (ARBs), focusing on heart failure, angina, percutaneous coronary intervention (PCI), and renal protection.
  
  
  METHODS
  A MEDLINE search (1966-December 2001) was completed using amlodipine, angiotensin-receptor antagonist, losartan, valsartan, candesartan, and telmisartan as key words. English-language articles were identified and included.
  
  
  METHODS
  All identified articles were evaluated. Articles representative of the subject matter of our review were included.
  
  
  RESULTS
  Amlodipine and the ARBs lower blood pressure to a similar extent. Amlodipine is an effective antianginal agent, whereas ARBs are not. However, amlodipine is not effective in the treatment of heart failure; ARBs may be useful in this setting. ARBs are also effective in preserving renal function and may provide some protection from restenosis in patients who have had a PCI. The ARBs may also be useful in preventing both diabetic and nondiabetic nephropathy.
  
  
  CONCLUSIONS
  Concomitant disease states should be considered when choosing between an ARB and amlodipine for the management of hypertension.
authors.affiliation: Hartford Hospital/University of Connecticut, Hartford, CT, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Kalus
authors.forename: C Michael
authors.initials: CM
authors.lastname: White
mesh_terms: D017311:Amlodipine / Q000009:adverse effects / Q000627:therapeutic use; D000787:Angina Pectoris / Q000188:drug therapy*; D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D023903:Coronary Restenosis / Q000517:prevention & control; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic
chemical_list: D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D017311:Amlodipine