Structure and function of bacterial initiation factors.
Bacteria require three initiation factors, IF1, IF2 and IF3, to start protein synthesis. In the last few years the elucidation of both structural and mechanistic aspects pertaining to these proteins has made substantial progress. In this article we outline the translation initiation process in bacteria and review these recent developments giving a summary of the main features of the structure and function of the initiation factors.
Boelens
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Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. boelens@nmr.chem.uu.nl
Gualerzi
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D001426:Bacterial Proteins / Q000737:chemistry* / Q000502:physiology; D010448:Peptide Initiation Factors / Q000737:chemistry* / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D010448:Peptide Initiation Factors