Bone morphogenetic proteins: relevance in spine surgery.
Bone morphogenetic proteins (BMPs) are low molecular weight glycoproteins that play a vital role in the development and maturation of skeletal tissue. Bone morphogenetic protein-induced mesenchymal cell recruitment and differentiation leads to the formation of chondroblasts and osteoblasts leading to the formation of de novo bone. Overwhelming pre-clinical and clinical evidence has suggested a promising role for BMPs for anterior and posterolateral spinal fusion. Strength of this approach lies in the potential ability of these growth factors to reverse inhibitory conditions common in the clinical setting and enabling predictable fusion. However, several issues related to carriers, costs, and dosages still need to be consecutively addressed. Gene therapy techniques producing in vivo osteoinductive factors and utilizing minimally invasive approaches are attractive options being developed for the future.
Khan
Safdar N
SN
Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA.
Sandhu
Harvinder S
HS
Lane
Joseph M
JM
Cammisa
Frank P
FP
Girardi
Federico P
FP
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology / Q000627:therapeutic use*; D004285:Dogs; D006041:Goats; D000882:Haplorhini; D006801:Humans; D011817:Rabbits; D012756:Sheep; D013122:Spinal Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D013123:Spinal Fusion
D019485:Bone Morphogenetic Proteins