Diagnosis of Down's syndrome in neonates.
The results of karyotyping for Down's syndrome in neonates were surveyed. From local data 36%, and from a national questionnaire, 32% of such samples were negative for Down's syndrome. To examine this, a subset of notes was reviewed for documentation of clinical signs of Down's syndrome. Some characteristics were often recorded, but other common discriminatory characteristics were noted less often or not at all.
Hindley
D
D
Fairfield General Hospital, Bury BL9 7TD, Greater Manchester, UK. dthindley@hotmail.com
Medakkar
S
S
D004314:Down Syndrome / Q000175:diagnosis*; D005189:False Positive Reactions; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping / Q000379:methods