[Changes in the hemodynamic parameters of the portal vein and serum fibrosis markers in patients with chronic viral hepatitis B].
OBJECTIVE
To explore the relationship between portal vein hemodynamics and the severity of fibrosis in patients with chronic hepatitis.


METHODS
Portal vein blood flow velocity (PBFVe) and volume (PBFVo) along with the serum fibrosis markers were examined in 71 patients with chronic viral hepatitis B, and hepatic pathological changes were routinely observed.


RESULTS
As the hepatitis progressed, the PBFVe decreased in close inverse relation to the degree of liver fibrosis (P<0.01) and the levels of the serum fibrosis markers hyaluronic (HA) and collagen IV (IV-C). The PBFVo, however, was not related with the fibrotic status in the patients, but was reduced as the hepatic inflammatory reaction escalated.


CONCLUSIONS
PBFVe is a more sensitive indicator for assessing portal hemodynamics than PBFVo in chronic hepatitis progression, and when combined with serum HA and IV-C levels, it may demonstrate the severity of hepatic fibrosis. PBFVo together with procollagen III level, however, can be meaningful for deciding the intrahepatic inflammation activity.
Yang
Yong-Ping
YP
Third Department, 302 Hospital of PLA, Beijing 100039, China.
Zhan
Shi-Lan
SL
Li
Ya-Jie
YJ
Zhang
Wei
W
Wang
Cheng-Wu
CW
Song
Xi-Xiu
XX
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001810:Blood Volume; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000503:physiopathology
D015415:Biomarkers