title: Ischemic preconditioning of myocardium.
abstract: Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel, and expression of many protective proteins. The purpose of this review is to assess the current position in this field and to facilitate future research.
authors.affiliation: Department of Pharmacology, Maulana Azad Medical College, New Delehi 110002, India. priyatyagi@hotmail.com
authors.forename: Priya
authors.initials: P
authors.lastname: Tyagi
authors.forename: Girish
authors.initials: G
authors.lastname: Tayal
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D011493:Protein Kinase C / Q000378:metabolism; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D011493:Protein Kinase C; D010738:Type C Phospholipases; D000241:Adenosine; D001920:Bradykinin