An isorhapontigenin tetramer and a novel stilbene dimer from Gnetum hainanense.
The first isorhapontigenin tetramer, gnetuhainin R (1) and a novel dimeric stilbene, gnetuhainin S (2) were isolated from the lianas of Gnetum hainanense. Their structures were elucidated on the basis of spectroscopic and chemical evidence, especially 2D NMR analysis. The structure of 2 was further supported by X-ray crystallographic analysis. The anti-inflammatory activity of 1 has been tested, and it showed potent activity of histamine receptor antagonism.
Huang
Kai-Sheng
KS
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Zhou
Shan
S
Lin
Mao
M
Wang
Ying-Hong
YH
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D035684:Gnetum; D006168:Guinea Pigs; D006632:Histamine; D007082:Ileum / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects*; D008517:Phytotherapy; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D013267:Stilbenes; C432307:isorhapontigenin; D006632:Histamine