title: Interactions of focal cortical lesions with error processing: evidence from event-related brain potentials.
abstract: Electrophysiological and hemodynamic studies have suggested that structures in the vicinity of the anterior cingulate cortex are involved in performance monitoring, particularly in detection of errors. Bidirectional interactions between the frontomedian system involved in performance monitoring and the lateral prefrontal cortex as well as the orbitofrontal cortex have been proposed, but few studies have directly addressed this issue. The authors used a speeded flankers task to investigate error-related event-related potentials in 3 patient groups with different focal cortical lesions. Whereas bilateral frontopolar lesions involving the orbitofrontal cortex as well as temporal lesions did not alter the error-related negativity (ERN), lesions of the lateral frontal cortex resulted in an abolition of the ERN and in a reduction of the error positivity.
authors.affiliation: Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany. ullsperg@cns.mpg.de
authors.forename: Markus
authors.initials: M
authors.lastname: Ullsperger
authors.forename: D Yves
authors.initials: DY
authors.lastname: von Cramon
authors.forename: Notger G
authors.initials: NG
authors.lastname: Müller
mesh_terms: D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology*; D004569:Electroencephalography; D004585:Electrooculography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000098:blood supply / Q000503:physiopathology; D011930:Reaction Time