[Circulating immune complexes in acute and prolonged hepatitis A infection].
Level and dynamics activity of circulating immune complexes (CiC) and persistence CiC in the sera in the acute and prolonged HAV-infection was examined. In the same time we explored the relation of level and dynamics CiC compared with level, dynamics and persistence length ALT and IgM anti-HAV in sera, longitude excretion HAV Ag in stool and intensity patohistological damage in liver. Research have been undertaken in the prospected study on two groups with 90 patients in total: 60 patients with prolonged form of the hepatitis A, and 30 patients with HAV-infection with normal development. CiC was prescribe with fotometer in sediment of poliethilenglicol, and IgM anti HAV with ELISA technique. Ag-HAV in stool was prescribe with methodImmuno/electro/osmophoresis. Results of examination showed that high level values of CiC had present in all patients with HAV-infection, bat yet middle values of CiC had significantly higher in prolonged forms (p < 0.01). In a case of patients with PTHA CiC persistence almost three times longer than in HAV infection with normal development. The highest value of CiC have been found from one to two weeks after e peak ALT in HAV and in PTHA 4-6 weeks later. Persistence of elevated values CiC responded to the middle length persistence of Igm anti HAV-in the sera.
Dautović-Krkić
Sajma
S
Klinika za infektivne bolesti, KCU Sarajevo, Bosna i Hercegovina.
Gribajcević
Mehmed
M
D000208:Acute Disease; D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000097:blood*; D005260:Female; D006506:Hepatitis A / Q000276:immunology*; D006801:Humans; D008297:Male
D000936:Antigen-Antibody Complex