Polyamine metabolism as chemotherapeutic target in protozoan parasites.
Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.
Bacchi
C J
CJ
Haskins Laboratories and Department of Biology, Pace University, 41 Park Row, New York, NY 10038, USA. cbacchi@pace.edu
Yarlett
N
N
D012437:Adenosylmethionine Decarboxylase / Q000037:antagonists & inhibitors; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D000518:Eflornithine / Q000494:pharmacology / Q000627:therapeutic use; D056890:Eukaryota / Q000187:drug effects* / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism*; D011528:Protozoan Infections / Q000188:drug therapy
D000981:Antiprotozoal Agents; D011073:Polyamines; D012437:Adenosylmethionine Decarboxylase; D000518:Eflornithine