title: Bioactive constituents from Iryanthera megistophylla.
abstract: Activity-guided fractionation of the 95% ethanol extract from the stem bark of Iryanthera megistophylla led to the isolation of two new compounds, named megislignan [2,3-dimethyl-4-(4-methoxyphenyl)-6-hydroxynaphthalene] (1) and megislactone [(2R,3R,4R)-3-hydroxy-4-methyl-2-(hexacos-17-enyl)butanolide] (2), along with seven known compounds, grandinolide (3), iryantherin K (4), iryantherin L (5), cinchonain I b (6), cinchonain I a (7), procyanidin B-2 (8), and cinchonain IIa (9). The structures of the new compounds were elucidated by spectral data interpretation. Isolates were evaluated for their antibacterial, antifungal, antiviral, and antiacetylcholinesterase activities.
authors.affiliation: Department of Botany, University of British Columbia, #3529-6270 University Boulevard, Vancouver, Canada V6T 1Z4.
authors.forename: Dong Sheng
authors.initials: DS
authors.lastname: Ming
authors.forename: Andrés
authors.initials: A
authors.lastname: López
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Hillhouse
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: French
authors.forename: Jim B
authors.initials: JB
authors.lastname: Hudson
authors.forename: G H Neil
authors.initials: GH
authors.lastname: Towers
mesh_terms: D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification*; D026324:Myristicaceae / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D001685:Biological Factors