Resorbable posterolateral graft containment in a rabbit spinal fusion model.
The effect of a resorbable graft containment device was evaluated in a rabbit posterolateral lumbar spinal fusion model. Twenty rabbits were divided into four groups: autogenous bone graft (ABG), ABG with the MacroPore containment device (MacroPore Biosurgery Inc, San Diego, Calif) (ABG+MP), demineralized bone matrix (DBM), and DBM with the containment device (DBM+MP). Fusion mass was assessed at 6 weeks with high resolution radiographs and volumetric computed tomography (CT). The graft containment device was associated with alteration of the fusion mass structure and significant enhancement of fusion mass volume (ABG versus ABG+MP, P=.027; DBM versus DBM+MP, P=.043). A bioabsorbable, protective graft containment device successfully enhanced posterolateral spinal fusion mass volume.
Poynton
Ashley R
AR
Department of Metabolic Bone Diseases and Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.
Tomin
Emre
E
Cornwall
G Bryan
GB
Zheng
Fengyu
F
Lane
Joseph M
JM
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods*; D003131:Combined Modality Therapy; D006084:Graft Rejection; D006085:Graft Survival; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery*; D008422:Materials Testing; D023421:Models, Animal; D011336:Probability; D011474:Prosthesis Design; D012680:Sensitivity and Specificity; D012756:Sheep; D013123:Spinal Fusion / Q000295:instrumentation / Q000379:methods*; D014182:Transplantation, Autologous
D001672:Biocompatible Materials