title: Ivermectin toxicosis after topical administration in dog-faced fruit bats (Cynopterus brachyotis).
abstract: Forty dog-faced fruit bats (Cynopterus brachyotis) were administered 1 drop of 1% ivermectin topically as part of a routine physical exam and deworming program, and 11 developed sudden generalized paresis. Six of the bats recovered within 24-48 hr, and the remaining 5 were presented recumbent and weak to the University of Florida Veterinary Medical Teaching Hospital. Ivermectin toxicosis was suspected, and the admitted bats died or were euthanatized within 3-5 days of the development of clinical signs despite supportive care. Three of the dead bats had renal tubular necrosis.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126, USA.
authors.forename: Julie H
authors.initials: JH
authors.lastname: DeMarco
authors.forename: Darryl J
authors.initials: DJ
authors.lastname: Heard
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Fleming
authors.forename: Brad A
authors.initials: BA
authors.lastname: Lock
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Scase
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002685:Chiroptera; D007306:Insecticides / Q000008:administration & dosage / Q000506:poisoning*; D007559:Ivermectin / Q000008:administration & dosage / Q000506:poisoning*; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D008297:Male; D011041:Poisoning / Q000209:etiology / Q000473:pathology / Q000662:veterinary
chemical_list: D007306:Insecticides; D007559:Ivermectin