title: Controlled photochemical release of nitric oxide from O(2)-naphthylmethyl- and O(2)-naphthylallyl-substituted diazeniumdiolates.
abstract: The photochemistry of O2-naphthylmethyl- and O2-naphthylallyl-substituted diazeniumdiolates has been investigated. Electron-donating methoxy group substitution is shown to have a significant effect on the observed photochemistry, with the appropriate substitution pattern resulting in efficient diazeniumdiolate photorelease. Observed nitric oxide release rates from these photoprecursors are consistent with those expected for normal thermal dissociation of the diazeniumdiolate in aqueous solutions and show the same pH dependence.
authors.affiliation: Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
authors.forename: K Mani
authors.initials: KM
authors.lastname: Bushan
authors.forename: Hua
authors.initials: H
authors.lastname: Xu
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Ruane
authors.forename: Raechelle A
authors.initials: RA
authors.lastname: D'Sa
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Pavlos
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Smith
authors.forename: Tevye C
authors.initials: TC
authors.lastname: Celius
authors.forename: John P
authors.initials: JP
authors.lastname: Toscano
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D009281:Naphthalenes / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry*; D010782:Photolysis
chemical_list: D001391:Azo Compounds; D009281:Naphthalenes; D020030:Nitric Oxide Donors; C452539:diazeniumdiolate; D009569:Nitric Oxide