Streptococcal exanthem in a blaschkolinear pattern: clinical evidence for genetic mosaicism in hypomelanosis of ito.
Due to the presence of two different clones of cells in early embryogenesis, numerous congenital and acquired dermatoses have a linear distribution following the lines of Blaschko. Acquired inflammatory skin diseases are rarely observed in linear patterns. Our patient was born with macrocephaly, left eye glaucoma, and a left facial and contralateral corporal hemihypertrophy, cerebral dysgenesis, and skeletal abnormalities. Hypopigmented S-shaped linear macules on the trunk and linear streaks on the arms and legs were compatible with hypomelanosis of Ito. At 5 years of age the patient presented with an erythematous follicular exanthem compatible with scarlet fever exclusively in the lines of Blaschko. This fact suggests a genetic mosaicism.
Durán-McKinster
Carola
C
Departments of Dermatology, National Institute of Pediatrics of Mexico, Mexico City, Mexico.
Moises
Celia
C
Rodríguez-Jurado
Rodolfo
R
Tamayo-Sánchez
Lourdes
L
Orozco-Covarrubias
Luz
L
Ruiz-Maldonado
Ramón
R
D002675:Child, Preschool; D005076:Exanthema / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000150:complications* / Q000235:genetics*; D009030:Mosaicism / Q000235:genetics*; D010406:Penicillins / Q000627:therapeutic use; D012879:Skin Physiological Phenomena / Q000235:genetics; D013290:Streptococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D013297:Streptococcus pyogenes / Q000302:isolation & purification*
D010406:Penicillins