title: Effects of stereochemistry of sugars on protein stabilities.
abstract: We investigated thermal stabilities of four proteins in the presence of four kinds of sugars to analyze the mechanism of stabilization of proteins by additives. These proteins were stabilized by the addition of sugars, and the degree of stabilization correlated to the partial molar isentropic compressibility of the sugar.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Kiyonari
authors.initials: K
authors.lastname: Masumoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ueda
authors.forename: Makiko
authors.initials: M
authors.lastname: Nagata
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Taiji
authors.initials: T
authors.lastname: Imoto
mesh_terms: D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*; D004795:Enzyme Stability; D006358:Hot Temperature; D007700:Kinetics; D011489:Protein Denaturation; D011506:Proteins / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D011506:Proteins