title: The efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria in Laos.
abstract: To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.
authors.affiliation: Epicentre, 8 rue Saint Sabin, 75011 Paris, France. jguthmann@epicentre.msf.org
authors.forename: J-P
authors.initials: JP
authors.lastname: Guthmann
authors.forename: S
authors.initials: S
authors.lastname: Kasparian
authors.forename: R
authors.initials: R
authors.lastname: Phetsouvanh
authors.forename: N
authors.initials: N
authors.lastname: Nathan
authors.forename: M
authors.initials: M
authors.lastname: Garcia
authors.forename: S
authors.initials: S
authors.lastname: Phompida
authors.forename: A
authors.initials: A
authors.lastname: Brockman
authors.forename: M
authors.initials: M
authors.lastname: Gastellu
authors.forename: D
authors.initials: D
authors.lastname: Legros
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007812:Laos; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000235:genetics; D011786:Quality Control; D012008:Recurrence; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D002738:Chloroquine