Is arterial hypertension an underlying factor in the increased serum Lp(a) levels in ESRD dialyzed patients?
Except for the disorders in lipoprotein metabolism several other factors have been involved in the development of atherosclerotic changes in ESRD patients, including arterial hypertension. Serum lipid profile (total cholesterol (TC), triglycerides (TG), apolipoproteins (AI,AII,B,E) and Lp(a)) was evaluated in 109 ESRD dialyzed patients, 46 in HD and 63 in CAPD and 45 hyperlipidemic patients without renal failure (HL-group). According to the presence of arterial hypertension the dialyzed patients were divided in two groups: group A of 42 hypertensive patients, (mean age 62.3 +/- 15.5 years), which were satisfactorily controlled with anti-hypertensive medication, and group B of 67 non-hypertensive patients, (mean age 66.6 +/- 11.9 years). Lp(a) levels were statistically significantly higher than HL group in both HD (p = 0.001) and PD (p < 0.05) patients. Besides, by dividing HD and PD group in hypertensive and non-hypertensive patients, Lp(a) levels were statistically significantly higher in hypertensive patients, while such a difference was not observed among non-renal failure patients. These results indicate that arterial hypertension may play an important role in Lp(a) serum titles, in ESRD patients undergoing either HD or PD.
Fytili
Christina I
CI
Biochemical Department, G.H.N. Papanikolaou Thessaloniki, Greece.
Passadakis
Ploumis S
PS
Progia
Euaggelia G
EG
Kambouromiti
Georgia L
GL
Panopoulou
Maria I
MI
Sombolos
Kostas I
KI
Vargemezis
Vassilis A
VA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology* / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D006973:Hypertension / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D017270:Lipoprotein(a); D014280:Triglycerides; D002784:Cholesterol