title: Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 diabetes mellitus.
abstract: Autoimmune thyroiditis is often associated with Type 1 diabetes mellitus (T1DM). In non-obese adult-onset diabetes diagnosed initially as Type 2 diabetes mellitus (T2DM), there is a proportion of cases with so far undiagnosed T1DM. The objective of this study was to estimate the frequency of autoimmune thyroiditis (AT) among non-obese (BMI <30.0 kg/m2) patients with T2DM and to compare the frequency of AT in subgroups of patients according to the presence of glutamic acid decarboxylase antibodies (GADA), insulin requirement, and post-breakfast C-peptide levels. The study included 118 adult patients (55 men and 63 women) with the initial diagnosis of T2DM and age at the onset of diabetes > 35 yr. Median of age was 66 yr (range 39-82), and median duration of diabetes was 9 (range 1-27) yr. AT was diagnosed using thyroid peroxidase antibodies, TG-antibodies, US and TSH levels. Nineteen per cent of the subjects were found to have AT, and the frequency of AT did not significantly differ between the groups of GADA+ and GADA- subjects. There was no difference in the frequency of AT between the group treated with hypoglycemic agents and/or diet and the group requiring insulin. The frequency of AT was higher in the group with post-breakfast C-peptide levels < or = 0.8 nmol/l compared to the group with post-breakfast C-peptide levels > 0.8 nmol/l (37% vs 16%), however the group with post-breakfast C-peptide levels < or = 0.8 nmol/l had longer duration of diabetes.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic. mbehanova@endo.cz
authors.forename: M
authors.initials: M
authors.lastname: Matejková-Behanová
authors.forename: V
authors.initials: V
authors.lastname: Zamrazil
authors.forename: K
authors.initials: K
authors.lastname: Vondra
authors.forename: J
authors.initials: J
authors.lastname: Vrbíková
authors.forename: P
authors.initials: P
authors.lastname: Kucera
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: M
authors.initials: M
authors.lastname: Andel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000178:diet therapy / Q000188:drug therapy; D005260:Female; D005969:Glutamate Dehydrogenase / Q000276:immunology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000453:epidemiology*
chemical_list: D001323:Autoantibodies; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D005969:Glutamate Dehydrogenase