[Promotion of ferulic acid transdermal absorption by water-soluble azone in Shengfaling tincture].
OBJECTIVE
To investigate the effects of water soluble azone as an additive in Shengfaling tincture on transdermal absorption of ferulic acid and determine the optimum concentration to promote the absorption.


METHODS
Using a two-chamber diffusion cell, the amounts of ferulic acid that had permeated in vitro rat skin was determined by high-performance liquid chromatography at different time points after shengfaling tincture containing different concentrations of water-soluble azone was applied on the skin.


RESULTS
When shengfaling tincture contained 1.509% water-soluble azone, the maximum total release of ferulic acid (2 356.7 microgram) was achieved with the maximum release rate of 242.9 microgram/cm(2).h(-1).


CONCLUSIONS
Water-soluble azone can promote the transdermal absorption of ferulic acid in Shengfaling tincture with the optimal concentration of 1.509%.
Ma
Ping-Bo
PB
Department of Pharmacy, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001381:Azepines / Q000494:pharmacology*; D003373:Coumaric Acids / Q000493:pharmacokinetics*; D004357:Drug Synergism; D051379:Mice; D012869:Skin Absorption / Q000187:drug effects*; D012995:Solubility; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001381:Azepines; D003373:Coumaric Acids; D014867:Water; C035229:laurocapram; C004999:ferulic acid