title: The new MATH: homology suggests shared binding surfaces in meprin tetramers and TRAF trimers.
abstract: Although apparently functionally unrelated, intracellular TRAFs and extracellular meprins share a region with conserved meprin and traf homology, MATH(1). Both TRAFs and meprins require subunit assembly for function. By structural analysis of the sequences, we provide an explanation of how meprins, which form tetramers, and TRAF molecules, which form trimers, can share homology. Our analysis suggests it is highly likely that the same oligomerization surface is used. The analysis has implications for the widely distributed group of proteins containing MATH domains.
authors.affiliation: Molecular Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden. maria.sunnerhagen@mbb.ki.se
authors.forename: Maria
authors.initials: M
authors.lastname: Sunnerhagen
authors.forename: Sharon
authors.initials: S
authors.lastname: Pursglove
authors.forename: Malin
authors.initials: M
authors.lastname: Fladvad
mesh_terms: D000595:Amino Acid Sequence; D001704:Biopolymers; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D008625:Tiopronin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001704:Biopolymers; D002352:Carrier Proteins; D008625:Tiopronin