Pachyclavulariaenones D-G, new diterpenoids from the soft coral Pachyclavularia violacea.
Four new diterpenoids, pachyclavulariaenones D-G (1-4), have been isolated from the soft coral Pachyclavularia violacea. The structures and relative stereochemistry of metabolites 1-4 were established on the basis of extensive NMR studies and chemical methods. The structure, including the relative configuration of pachyclavulariaenone F (3), was further confirmed by a single-crystal X-ray analysis. Pachyclavulariaenone G (4) has been shown to exhibit significant cytotoxicity toward P-388 and HT-29 cancer cells.
Wang
Guey-Horng
GH
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, Republic of China.
Sheu
Jyh-Horng
JH
Duh
Chang-Yih
CY
Chiang
Michael Y
MY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes