Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Biaryl nitrile amines were prepared and found to have high affinity and selectivity for human and rat histamine H(3) receptors.
Faghih
Ramin
R
Neuroscience-Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6123, USA.
Dwight
Wesley
W
Vasudevan
Anil
A
Dinges
Jurgen
J
Conner
Scott E
SE
Esbenshade
Timothy A
TA
Bennani
Youssef L
YL
Hancock
Arthur A
AA
D000818:Animals; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000378:metabolism; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D008024:Ligands; D009570:Nitriles; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D018100:Receptors, Histamine H3