Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).
Three neurexin (NRXN) genes are known in humans, each transcribed from two promoters and extensively spliced at five canonical positions, thus generating thousands of isoforms. For NRXN3, only neuronal expression was reported so far. We reported here on the expression of NRXN3 in additional tissues (lung, pancreas, heart, placenta, liver, and kidney) and on the identification and characterization of heart-specific splicing variants of NRXN3. Cardiac isoforms of NRXN3 probably participate in a complex involving dystroglycan and proteins of extracellular matrix, involved in intercellular connections.
Occhi
Gianluca
G
Department of Biology, University of Padua, Via U. Bassi 58/B, Padua I-35131, Italy. danieli@bio.unipd.it
Rampazzo
Alessandra
A
Beffagna
Giorgia
G
Antonio Danieli
Gian
G
D017398:Alternative Splicing; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D022821:RNA Splice Sites; D012333:RNA, Messenger / Q000378:metabolism*; D014018:Tissue Distribution
D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D022821:RNA Splice Sites; D012333:RNA, Messenger; C082354:neurexin IIIalpha; C086958:neurexin IIIbeta