title: Temozolomide in second-line treatment after prior nitrosurea-based chemotherapy in glioblastoma multiforme: experience from a Portuguese institution.
abstract: Temozolomide is a new cytotoxic alkylating agent that has recently been approved in Portugal for the treatment of recurrent high-grade glioma. From September 1999 to March 2001, 16 patients with recurrent glioblastoma multiforme who had prior nitrosurea-based chemotherapy [procarbazine, carmustine, vincristine (PCV)] were given temozolomide 150-200 mg/m2/day for 5 days every 28-day cycle. The estimated 1-year survival rate was 16% and the median overall survival was 6.5 months. Despite the small sample size, the overall survival achieved with temozolomide was similar to that of other reports. These promising data suggest that randomized trials should be undertaken to assess its use in first-line therapy its inclusion in combined chemotherapy regimes and its effectiveness with concurrent radiotherapy.
authors.affiliation: Medical Oncology Department, Francisco Gentil Portuguese Institute of Oncology, Coimbra Regional Oncology Center.
authors.forename: M M
authors.initials: MM
authors.lastname: Teixeira
authors.forename: I
authors.initials: I
authors.lastname: Garcia
authors.forename: I
authors.initials: I
authors.lastname: Portela
authors.forename: M
authors.initials: M
authors.lastname: Cernuda
authors.forename: C
authors.initials: C
authors.lastname: Oliveira
authors.forename: J
authors.initials: J
authors.lastname: Albano
authors.forename: L
authors.initials: L
authors.lastname: Lima
mesh_terms: D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005909:Glioblastoma / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008875:Middle Aged; D011174:Portugal; D016019:Survival Analysis; D015996:Survival Rate; D000077204:Temozolomide; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide