title: A cytogenetic study of Kuwaiti couples with infertility and reproductive disorders: short arm deletion of chromosome 21 is associated with male infertility.
abstract: Chromosomal anomalies may be a reason for both male and female infertility. The aim of this study was to investigate the contribution of chromosomal abnormalities in sterile couples from Kuwait. A total of 118 patients with clinical diagnosis of infertility was analyzed using cytogenetic banding techniques. Common chromosomal abnormalities were detected in 12 patients. We describe here one new case of an infertile male with the karyotype 46,XY, del(21)(pter;q11.2). The overall incidence of 11% abnormality indicates that routine chromosome analysis of infertile couples in Kuwait should be considered before the planning of intracytoplasmic sperm injection.
authors.affiliation: Cytogenetics Laboratory, Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat, Kuwait. m_alkhalaf@hsc.kuniv.edu.kw
authors.forename: Moussa
authors.initials: M
authors.lastname: Alkhalaf
authors.forename: Lilly
authors.initials: L
authors.lastname: Verghese
authors.forename: Nabil
authors.initials: N
authors.lastname: Muharib
mesh_terms: D000328:Adult; D002891:Chromosomes, Human, Pair 21; D041321:Chromosomes, Human, X; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000235:genetics*; D007713:Klinefelter Syndrome / Q000235:genetics; D007730:Kuwait; D008297:Male; D017384:Sequence Deletion; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone