Developmental changes in lysosome morphology and function Leishmania parasites.
The endocytic pathway of Leishmania parasites has recently come under intense research focus through the development of several markers for various compartments of this pathway. Through these studies a novel multivesicular tubule lysosome has been discovered in promastigote-stage parasites. This organelle has a highly dynamic role during parasite growth and differentiation. This review discusses recent insights into the Leishmania lysosome with respect to its organisation within the endocytic pathway, stage-specific functions, and biogenesis.
Waller
Ross F
RF
Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Vic 3010, Australia.
McConville
Malcolm J
MJ
D000818:Animals; D001693:Biological Transport, Active; D004705:Endocytosis; D007891:Leishmania / Q000166:cytology* / Q000254:growth & development* / Q000276:immunology / Q000648:ultrastructure; D008247:Lysosomes / Q000276:immunology / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D015800:Protozoan Proteins / Q000378:metabolism
D015800:Protozoan Proteins