Cognitive and physiologic correlates of subclinical structural brain disease in elderly healthy control subjects.
BACKGROUND
Healthy elderly persons commonly show 4 types of change in brain structure-cortical atrophy, central atrophy, deep white-matter hyperintensities, and periventricular hyperintensities-as forms of subclinical structural brain disease (SSBD).


OBJECTIVE
To characterize the volumes of SSBD present with aging and to determine the associations of SSBD, physiology, and cognitive function.


METHODS
Cross-sectional study.


METHODS
University of California, Los Angeles, Neuropsychiatric Institute.


METHODS
Forty-three community-dwelling healthy control subjects, aged 60 through 93 years.


METHODS
Volumetric magnetic resonance imaging, neuropsychological testing, and quantitative electroencephalographic coherence (functional connectivity) between brain regions.


RESULTS
Regression models demonstrated significant relationships between SSBD volumes, age, cognitive performance, and connectivity. Cortical and central atrophy and periventricular hyperintensities had significant associations with age while deep white-matter hyperintensities did not. Posterior atrophy showed stronger associations with age than did anterior atrophy. Only a subset of subjects at older ages showed large SSBD volumes; older subjects primarily showed increasing variance of SSBD. Although all subjects scored within the normal range on cognitive testing, SSBD volume was inversely related to performance, most notably on the Trail-Making Test part B and the Shipley-Hartford Abstract Reasoning test. Coherence had significant associations with SSBD. Path analysis supported mediation of the effects of deep white-matter hyperintensities and periventricular hyperintensities on cognition by altered connectivity. For several measures, cognitive performance was best explained by coherence, and only secondarily by SSBD.


CONCLUSIONS
Modest volumes of SSBD were associated with decrements in cognitive performance within the normal range in healthy subjects. Lower coherence was associated with greater volumes of SSBD and increasing age. Path analysis models suggest that brain functional connectivity mediates some effects of SSBD on cognition.
Cook
Ian A
IA
University of California, Los Angeles, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA. icook@ucla.edu
Leuchter
Andrew F
AF
Morgan
Melinda L
ML
Conlee
Elise Witte
EW
David
Steven
S
Lufkin
Robert
R
Babaie
Ashkan
A
Dunkin
Jennifer J
JJ
O'Hara
Ruth
R
Simon
Sara
S
Lightner
Amy
A
Thomas
Susan
S
Broumandi
David
D
Badjatia
Neeraj
N
Mickes
Laura
L
Mody
Rajal K
RK
Arora
Sanjaya
S
Zheng
Zimu
Z
Abrams
Michelle
M
Rosenberg-Thompson
Susan
S
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged