A novel catheter design for laser photocoagulation of the myocardium to ablate ventricular tachycardia.
Nd:YAG laser energy has been proposed as an alternative to radiofrequency energy for ablation of ventricular tachycardia (VT) associated with coronary artery disease (CAD) in an effort to increase lesion size and success rates. However, issues of catheter design to maintain flexibility and ensure adequate tissue contact have hindered development of laser catheters. We developed and tested a prototype 8 Fr. steerable catheter with a flexible and extendible tip (designed to ensure tissue contact and efficient ventricular mapping), which projects the laser beam through a side port containing a lens-tipped optical fiber that rests against the endocardial surface. The catheter has a channel for simultaneous saline irrigation to displace the interceding blood and discharge a laser beam between two electrodes for bipolar mapping and a thermocouple for temperature monitoring. The catheter was tested on bench top using the epicardial surface of freshly slaughtered bovine hearts and in vivo using six anaesthetized closed-chest sheep. In vitro experiments demonstrated that lesion size increased linearly with applied power up to 40 watts. When compared to radio frequency, laser energy penetrated more deeply into the myocardium. In the in vivo studies, using increasing powers of up to 40 watts for application times of 60 to 120 seconds created circular or elliptical lesions with surface dimensions up to 12 mm x 12 mm and depth of 9 mm (full LV wall thickness with a mean lesion diameter of 9.9 +/- 5.2 mm and depth 5.8 +/- 3.2 mm). Most lesions, 16 total in both right and left ventricular walls were transmural or near transmural in thickness. Lesions demonstrated coagulation necrosis with smooth well-demarcated borders. No animal suffered cardiac perforation, hypotension, hemopericardium, damage to cardiac valves, or cavitation effect from any of the ablations. Runs of VT were seen during energy application at the highest laser outputs in two animals. In conclusion, this catheter design provides effective endocardial delivery of laser energy and is capable of creating transmural or nearly transmural lesions in vivo and in vitro, thereby potentially increasing the efficiency of VT ablation in CAD patients.
Wagshall
Alan
A
University of Massachusetts, Worchester, MA, USA.
Abela
George S
GS
Maheshwari
Alok
A
Gupta
Anoop
A
Bowden
Russell
R
Huang
S K Stephen
SK
D000818:Animals; D002404:Catheterization / Q000592:standards*; D002417:Cattle; D004195:Disease Models, Animal; D022062:Electrophysiologic Techniques, Cardiac / Q000295:instrumentation; D004867:Equipment Design; D066298:In Vitro Techniques; D017075:Laser Coagulation / Q000295:instrumentation*; D008422:Materials Testing; D012756:Sheep; D017180:Tachycardia, Ventricular / Q000473:pathology / Q000601:surgery*