Multiple sclerosis-associated retrovirus and MS prognosis: an observational study.
MS-associated retrovirus (MSRV) in the CSF may have gliotoxic properties and could be associated with a more disabling MS. The authors tested this hypothesis in 15 untreated patients with MS: 6 MSRV- and 9 MSRV+ at the time of CSF withdrawal. After a 3-year mean follow-up, MSRV- patients showed a stable MS course, whereas MSRV+ patients had a progressive course (p = 0.01).
Sotgiu
S
S
Institute of Clinical Neurology, University of Sassari, Italy. stesot@hotmail.com
Serra
C
C
Mameli
G
G
Pugliatti
M
M
Rosati
G
G
Arru
G
G
Dolei
A
A
D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000821:virology*; D011379:Prognosis; D012190:Retroviridae / Q000302:isolation & purification*; D012192:Retroviridae Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000821:virology*