Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes.
Linkage analyses of highly heritable electrophysiological phenotypes (EEG, ERP) that can potentially identify individuals at risk for alcoholism were performed on a large sample of families with a high density of alcohol dependence as part of the Collaborative Study on the Genetics of Alcoholism (COGA); these genetic findings are summarized. Quantitative trait loci (QTLs) were identified for several ERP characteristics (P300, N100, N400) and for the beta frequencies of the EEG where we report linkage and linkage disequilibrium at a GABA(A) receptor gene on chromosome 4. Genetic analyses of ERPs suggest that several regions of the human genome contain genetic loci related to the generation of N100, N400 and P300, which are possible candidate loci underlying the functional organization of human neuroelectric activity. The advent of genomics and proteomics and a fuller understanding of gene regulation, will open new horizons on the critical electrical events so essential for human brain function.
Porjesz
Bernice
B
Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, Box 1203, HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA. bp@cns.hscbklyn.edu
Begleiter
Henri
H
Wang
Kongming
K
Almasy
Laura
L
Chorlian
David B
DB
Stimus
Arthur T
AT
Kuperman
Samuel
S
O'Connor
Sean J
SJ
Rohrbaugh
John
J
Bauer
Lance O
LO
Edenberg
Howard J
HJ
Goate
Alison
A
Rice
John P
JP
Reich
Theodore
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D001611:Beta Rhythm; D002540:Cerebral Cortex / Q000503:physiopathology; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000235:genetics; D005071:Evoked Potentials / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D040641:Quantitative Trait Loci; D011963:Receptors, GABA-A / Q000235:genetics
D011963:Receptors, GABA-A