Different h2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice.
Melanoma cells and tissues contain considerable amounts of histamine and express histamine receptors, suggesting the existence of autocrine and paracrine regulation by histamine. Our previous in vitro results suggested that histamine elevates melanoma cell growth through the H2 receptor. In this work we show that in vivo tumour proliferation in immunodeficient mice xenotransplanted with a human melanoma cell line is diminished by cimetidine, an H2 receptor antagonist, if combined with a tamoxifen derivate acting on cytochrome p450 molecules (DPPE). Ranitidine, another H2 receptor antagonist, has a weaker inhibitory effect, the kinetics and mechanism of which is probably dissimilar to that of the cimetidine/DPPE mixture.
Szincsák
Nora
N
Department of Dermatology, Debrecen University, Debrecen, Hungary.
Hegyesi
Hargita
H
Hunyadi
Janos
J
Falus
Andras
A
Juhász
Istvan
I
D000368:Aged; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D005021:Ethylamines / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008545:Melanoma; D051379:Mice; D016513:Mice, SCID; D010647:Phenyl Ethers; D011899:Ranitidine / Q000494:pharmacology; D011970:Receptors, Histamine H2 / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
D001559:Benzhydryl Compounds; D005021:Ethylamines; D006635:Histamine H2 Antagonists; D010647:Phenyl Ethers; D011970:Receptors, Histamine H2; D002927:Cimetidine; D011899:Ranitidine; C043062:tesmilifene