title: [Synthesis and pharmacological study of three 1-alkyl-3-(ethoxycarbonylmethylene)-2-oxo quinoxalines].
abstract: The acute toxicity study and the psychotropic activity of three alkylated derivatives of 3-(ethoxycarbonylmethylene) -2-oxo quinoxaline did not demonstrate any toxicity of these products at therapeutic dosages. In the animal, these compounds have sedative, myorelaxant and anxiolytic properities.
authors.affiliation: Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, BP 1014, Avenue Ibn Battouta, Rabat, Maroc, France.
authors.forename: S
authors.initials: S
authors.lastname: Ferfra
authors.forename: A
authors.initials: A
authors.lastname: Zellou
authors.forename: E M
authors.initials: EM
authors.lastname: Essassi
authors.forename: Y
authors.initials: Y
authors.lastname: Cherrah
authors.forename: M
authors.initials: M
authors.lastname: Hassar
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D003009:Clorazepate Dipotassium / Q000494:pharmacology; D004347:Drug Interactions; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D011619:Psychotropic Drugs; D011810:Quinoxalines; D003009:Clorazepate Dipotassium