Classifying toxicity and pathology by gene-expression profile--taking a lead from studies in neoplasia.
Microarray technology has given rise to the ability to classify and predict toxin-induced pathological change using gene-expression profiles. However, to date gene-expression profiling of pathological subtype has been exploited mainly in the pathological classification of neoplasia. Using an example of resistance to doxorubicin in vitro and gene-expression profiling in neoplasia, this article explores the potential and challenges for gene-expression profiling in the delineation and understanding of toxicity and toxin-induced pathological change.
Gant
Timothy W
TW
Medical Research Council Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, LE1 9HN, Leicester, UK. twg1@le.ac.uk
D000818:Animals; D016208:Databases, Factual; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D010641:Phenotype; D014118:Toxins, Biological / Q000145:classification* / Q000633:toxicity
D014118:Toxins, Biological