title: Chicken ghrelin and growth hormone-releasing peptide-2 inhibit food intake of neonatal chicks.
abstract: Ghrelin is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Ghrelin stimulates feeding in rats, however, intracerebroventricular (i.c.v.) injection of rat ghrelin inhibits feeding of neonatal chicks. In the present study, the effect of i.c.v. injection of different ghrelins including chicken and bullfrog ghrelin, and synthetic GH-releasing peptide (GHRP) on feeding of neonatal chicks was investigated. Chicken ghrelin strongly suppressed feeding. To compare the inhibitory effect, chicken and rat ghrelin were examined. The suppressive effect of feeding by chicken and rat ghrelin was almost identical. Bullfrog ghrelin contains a change in the acylated amino acid from Ser to Thr, strongly suppressed feeding. The i.c.v. injection of GHRP-2 (KP-102), a synthetic GHS, also inhibited feeding. These results indicate that the chicken GHS receptor is affected by several forms of GHS, and that food intake of neonatal chicks is inhibited by GHS receptor agonists.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Ei-suke
authors.initials: ES
authors.lastname: Saito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kaiya
authors.forename: Tomo
authors.initials: T
authors.lastname: Takagi
authors.forename: Izumi
authors.initials: I
authors.lastname: Yamasaki
authors.forename: D Michael
authors.initials: DM
authors.lastname: Denbow
authors.forename: Kenji
authors.initials: K
authors.lastname: Kangawa
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002645:Chickens; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D054439:Ghrelin; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D036361:Peptide Hormones / Q000494:pharmacology*; D011892:Rana catesbeiana; D051381:Rats
chemical_list: D054439:Ghrelin; D009842:Oligopeptides; D036361:Peptide Hormones; C091874:growth hormone-releasing peptide-2