title: Propentofylline after focal cortical lesion in the rat: impact on functional recovery and basic fibroblast growth factor expression.
abstract: The effects of propentofylline, a xanthine derivative and adenosine transport inhibitor, were evaluated following anteromedial cortex lesion in the rat. Propentofylline (2x/10 mg/kg, intraperitoneally) was administered for 7 days post-insult and basic fibroblast growth factor (bFGF) immunoreactivity measured at designated time points in the peri-lesional cortex and ipsilateral dorsal striatum. The spatiotemporal pattern of bFGF expression was then compared to functional recovery patterns. Propentofylline-treated animals displayed increased bFGF expression in the peri-lesional cortex which may have contributed to the observed early facilitation of functional recovery. Drug administration did not, however, produce a change in bFGF expression in the ipsilateral dorsal striatum compared to saline-treated animals. These findings taken together with other positive findings regarding propentofylline, support the drug's therapeutic potential.
authors.affiliation: UCHSC, Department of Clinical Pharmacology, Campus Box C237, 4200 East 9th Avenue, Denver, CO 80262, USA.
authors.forename: Kimberley A
authors.initials: KA
authors.lastname: Buytaert-Hoefen
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Kreber
authors.forename: Courtney J
authors.initials: CJ
authors.lastname: Millar
authors.forename: Uriah T
authors.initials: UT
authors.lastname: Walsh
authors.forename: Chris
authors.initials: C
authors.lastname: Brannigan
authors.forename: Theresa D
authors.initials: TD
authors.lastname: Hernandez
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D001930:Brain Injuries / Q000188:drug therapy*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism / Q000503:physiopathology; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D020318:Rats, Long-Evans; D020127:Recovery of Function; D014970:Xanthines / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D014970:Xanthines; D016222:Fibroblast Growth Factor 2; C032114:propentofylline