Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats.
The alterations of taurine transport and the expression of taurine transporter (TAUT) mRNA in myocardium and aortic wall were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. It was demonstrated that plasma taurine concentration and taurine release from myocardium and aortic wall in SHR were higher than those in WKY rats, whereas taurine content, taurine uptake and TAUT mRNA in myocardium and aortic wall of SHR were lower than those of WKY rats. In SHR, the maximal velocity (V(max)) of taurine transportation in myocardium and aortic wall was lower by 24% (P<0.05) and 35% (P<0.05) than that in WKY, their michaelis constants (Km) values were higher by 16% (P<0.05) and 39% (P<0.05), respectively. The results suggest that there is dysfunction of taurine transport in myocardium and aortic wall in SHR, which may be partly resulted from the decrease of TAUT activity and affinity, and down-regulation of TAUT gene expression.
Shi
Yan-Rong
YR
Institute of Cardiovascular Disease Research, The First Hospital of Peking University, Beijing, China.
Qi
Yong-Fen
YF
Bu
Ding-Fang
DF
Gao
Lin
L
Wang
Dong-Yan
DY
Jiang
Hong-Feng
HF
Pang
Yong-Zheng
YZ
Tang
Chao-Shu
CS
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000503:physiopathology; D002352:Carrier Proteins / Q000378:metabolism*; D006321:Heart / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013654:Taurine / Q000378:metabolism*
D002352:Carrier Proteins; D013654:Taurine