The role of fibroblast growth factors in vascular development.
Fibroblast growth factors (FGFs) are considered angiogenic factors, yet the exact relationship between FGF and vascular development in normal and pathological tissue has long remained elusive. However, recent results from gene inactivation and transgenic studies in mice and in culture systems have demonstrated the role of FGFs in vessel assembly and sprouting. FGFs also promote blood-vessel branching and induce lymphangiogenesis. Novel players in FGF-mediated angiogenesis have been identified, such as p38 mitogen-activated protein kinase. Tumour angiogenesis is regulated by FGFs directly or indirectly via secondary angiogenesis factors, such as vascular endothelial growth factor. The newly established angiogenic role of FGFs makes FGF or molecules targeting FGF and its receptor promising candidates for the development of novel therapeutics.
Javerzat
Sophie
S
INSERM EMI 0113, Molecular Mechanisms of Angiogenesis & Growth Factor and Cell Differentiation Laboratory, Université Bordeaux I, Avenue des Facultés, 33 405 Talence, France.
Auguste
Patrick
P
Bikfalvi
Andreas
A
D000818:Animals; D001808:Blood Vessels / Q000254:growth & development*; D004622:Embryo, Mammalian / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors