title: Different distributions of the 5-HT reuptake complex and the postsynaptic 5-HT(2A) receptors in Brodmann areas and brain hemispheres.
abstract: The aim of the present study was to determine the distribution of the presynaptic 5-HT reuptake complex and the 5-HT(2A) receptors through Brodmann areas from two control subjects, together with the possible existence of laterality between both brain hemispheres. A left laterality was observed in the postsynaptic 5-HT(2A) binding sites, with significantly higher B(max) values in the left frontal and cingulate cortex. In frontal cortex, [3H]imipramine and [3H]paroxetine binding showed the highest B(max) values in areas 25, 10 and 11. In cingulate cortex, the highest [3H]imipramine and [3H]paroxetine B(max) values were noted in Brodmann area 33 followed by area 24, while postsynaptic 5-HT(2A) receptors were mainly distributed through Brodmann areas 23 and 29. In temporal cortex, the highest [3H]imipramine and [3H]paroxetine B(max) was noted in Brodmann areas 28 and 34, followed by areas 35 and 38. All Brodmann areas from parietal cortex (1, 2, 3, 4, 5, 6, 7, 39, 40 and 43) showed similar presynaptic and postsynaptic binding values. In occipital cortex no differences were observed with regard to the brain hemisphere or to the Brodmann area (17, 18 and 19). These results suggest the need to carefully define the brain hemisphere and the Brodmann areas studied, as well to avoid comparisons between studies including different Brodmann areas or brain hemispheres.
authors.affiliation: Hormone and Genetic Unit, Department of Clinical Chemistry, CSUB Hospital Princeps d'Espanya, Feixa Llarga s/n, 08907 Barcelona, Spain. 24439bam@comb.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Rosel
authors.forename: Belén
authors.initials: B
authors.lastname: Arranz
authors.forename: Mikel
authors.initials: M
authors.lastname: Urretavizcaya
authors.forename: Miguel
authors.initials: M
authors.lastname: Oros
authors.forename: Luis
authors.initials: L
authors.lastname: San
authors.forename: Julio
authors.initials: J
authors.lastname: Vallejo
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Navarro
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002352:Carrier Proteins / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004292:Dominance, Cerebral / Q000502:physiology*; D006179:Gyrus Cinguli / Q000378:metabolism*; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017374:Paroxetine / Q000493:pharmacokinetics; D011869:Radioligand Assay; D044402:Receptor, Serotonin, 5-HT2A; D017661:Receptors, Presynaptic / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D044402:Receptor, Serotonin, 5-HT2A; D017661:Receptors, Presynaptic; D011985:Receptors, Serotonin; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D017374:Paroxetine; D007099:Imipramine