A new method for synthesis of 7-deoxytaxane analogues by hydrogenation of delta(6,7)-taxane derivatives.
A new method for the synthesis of 7-deoxytaxane analogues has been established through hydrogenation of Delta(6,7)-taxane derivatives. Among several catalysts examined, Pd-C was found to be a most effective catalyst for the preparation of target compound.
Takeda
Yasuyuki
Y
Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo R&D Center, Japan.
Yoshino
Toshiharu
T
Uoto
Kouichi
K
Terasawa
Hirofumi
H
Soga
Tsunehiko
T
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D043823:Taxoids
D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane