A novel method for preparation of Eudragit RL microcapsules.
A novel technique for the preparation of Eudragit RL microcapsules is described. The technique is based on the principle of solvent evaporation. Diclofenac sodium is used as a model drug for encapsulation. A solution of drug and Eudragit RL dissolved in acetone-isopropyl alcohol (1:1) is sprayed in liquid paraffin. The microcapsules obtained were uniform and free flowing particles. The release rate was more sustained by increasing the polymer concentration. The experimental procedure promises a rapid and convenient method for the preparation of Eudragit RL-microcapsules.
Satturwar
P M
PM
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur-440 010 (MS), India. satturwar@yahoo.com
Mandaogade
P M
PM
Dorle
A K
AK
D019840:2-Propanol; D000096:Acetone; D002214:Capsules; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011108:Polymers / Q000302:isolation & purification*; D012997:Solvents
D002214:Capsules; D003692:Delayed-Action Preparations; D011108:Polymers; D012997:Solvents; D000096:Acetone; D004008:Diclofenac; C058665:Eudragit RL; D019840:2-Propanol