Design, synthesis, and application of peptide secondary structure mimetics.
The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years is reviewed along with the recent developments in this field.
Eguchi
Masakatsu
M
Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA.
Kahn
Michael
M
D018360:Crystallography, X-Ray; D015195:Drug Design; D008958:Models, Molecular; D018716:Molecular Mimicry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017433:Protein Structure, Secondary
D010455:Peptides