title: [Loss to follow-up and cerebral palsy].
abstract: BACKGROUND
  The longer follow-up programs last, the greater the loss to follow-up. These losses to follow-up may undermine the completion of health care goals and the validity of study results.
  
  
  OBJECTIVE
  1) To compare neonatal characteristics in children easily followed-up and in those lost to follow-up. 2) To trace and assess children lost to follow-up. 3) To estimate the occurrence of cerebral palsy in children easily followed-up and in those lost to follow-up.
  
  
  METHODS
  From 1991 to 1997, 601 neonates with a birth weight under 1,500 g were admitted to the Neonatology Department. At discharge, 447 infants were included in the follow-up program. Moderate-to-severe cerebral palsy was assessed when the children were aged 2 years. A specific search strategy was implemented to find those children lost to follow-up. Data on the development of those traced were updated through a standardized telephone questionnaire.
  
  
  RESULTS
  Twenty percent of the children were lost to follow-up before the age of 2 years. Fifty-seven percent of those not available at this age were assessed by telephone interview. No differences were found in the neonatal characteristics of infants easily followed-up and those lost to follow-up except in situations of critical social disadvantage: 10 % in followed-up infants, 41 % in infants lost to follow-up. Disabling cerebral palsy was observed in 7 % of children easily followed-up and in 23 % of those lost and traced (relative risk: 3.1, 1.5-5.5).
  
  
  CONCLUSIONS
  The risk of having disabling cerebral palsy is three times higher in children lost to follow-up than in those easily followed-up. Dismissing this source of bias may underestimate disability rates when assessing health care programs or when interpreting study results.
authors.affiliation: Servicio de Neonatología, Hospital 12 de Octubre, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: López Maestro
authors.forename: C R
authors.initials: CR
authors.lastname: Pallás Alonso
authors.forename: J de
authors.initials: Jd
authors.lastname: La Cruz Bértolo
authors.forename: I
authors.initials: I
authors.lastname: Pérez Agromayor
authors.forename: E
authors.initials: E
authors.lastname: Gómez Castillo
authors.forename: C de
authors.initials: Cd
authors.lastname: Alba Romero
mesh_terms: D002547:Cerebral Palsy / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010342:Patient Acceptance of Health Care; D013997:Time Factors