title: A dinitrogenous alkaloid from Cyrtanthus obliquus.
abstract: The ethanolic extract of bulbs of Cyrtanthus obliquus (L.f.) Ait yielded the new dinitrogenous alkaloid obliquine (1), 3S, 4aS, 11S, 10bS-3,4,4a,13,11,5,6-heptahydro-5[2-(4-hydroxyphenyl)ethyl]-3-methoxy-13-methyl-[1,3-dioxolo[4,5-g]indolo[3,3a-c]-isoquinolin-12-one, together with the five known structures 11alpha-hydroxygalanthamine, 3-epimacronine, narcissidine, tazettine and trisphaeridine. All structures were established using 1D and 2D NMR techniques and HREIMS. The alkaloids were tested for cytotoxicity against two mammalian cell lines and did not show activity at concentrations up to 100 microg/ml.
authors.affiliation: Pharmacology Division, Department of Medicine, University of Cape Town, Observatory 7925, South Africa.
authors.forename: Natalie D
authors.initials: ND
authors.lastname: Brine
authors.forename: William E
authors.initials: WE
authors.lastname: Campbell
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
authors.forename: Maria R
authors.initials: MR
authors.lastname: Herrera
authors.forename: Francesc
authors.initials: F
authors.lastname: Viladomat
authors.forename: Carles
authors.initials: C
authors.lastname: Codina
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Smith
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000633:toxicity; D047151:Amaryllidaceae Alkaloids; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D007546:Isoquinolines; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D007546:Isoquinolines; C473532:obliquine