Treatment of pure red cell aplasia after major ABO-incompatible peripheral blood stem cell transplantation by induction of chronic graft-versus-host disease.
This report concerns a case of long-lasting pure red cell aplasia (PRCA) with a duration of 178 days after major ABO-incompatible allogeneic peripheral blood stem cell transplantation (PBSCT). The patient needed red blood cell transfusion every week from day 54 following PBSCT. He showed no evidence of GVHD and the dose of cyclosporin A (CsA) was reduced rapidly from day 123, followed by the development of chronic GVHD around day 145. The patient no longer needed transfusions from day 167, the reticulocyte count began to increase on day 179, and antidonor isohemagglutinin titers became undetectable. Chronic GVHD induced by tapering of CsA thus appeared to be related to improvement in PRCA.
Yamaguchi
M
M
Department of Hematology and Immunology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Sakai
K
K
Murata
R
R
Ueda
M
M
D000017:ABO Blood-Group System; D000328:Adult; D001787:Blood Group Incompatibility; D002908:Chronic Disease; D016572:Cyclosporine / Q000008:administration & dosage; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000628:therapy*; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000276:immunology
D000017:ABO Blood-Group System; D007518:Isoantibodies; D016572:Cyclosporine