Activation of thalamic ventroposteriolateral neurons by phrenic nerve afferents in cats and rats.
It has been demonstrated that phrenic nerve afferents project to somatosensory cortex, yet the sensory pathways are still poorly understood. This study investigated the neural responses in the thalamic ventroposteriolateral (VPL) nucleus after phrenic afferent stimulation in cats and rats. Activation of VPL neurons was observed after electrical stimulation of the contralateral phrenic nerve. Direct mechanical stimulation of the diaphragm also elicited increased activity in the same VPL neurons that were activated by electrical stimulation of the phrenic nerve. Some VPL neurons responded to both phrenic afferent stimulation and shoulder probing. In rats, VPL neurons activated by inspiratory occlusion also responded to stimulation on phrenic afferents. These results demonstrate that phrenic afferents can reach the VPL thalamus under physiological conditions and support the hypothesis that the thalamic VPL nucleus functions as a relay for the conduction of proprioceptive information from the diaphragm to the contralateral somatosensory cortex.
Zhang
Weirong
W
Department of Physiological Sciences, University of Florida, Gainesville 32610, USA.
Davenport
Paul W
PW
D000818:Animals; D002415:Cats; D003964:Diaphragm / Q000502:physiology; D004558:Electric Stimulation; D007839:Functional Laterality; D020647:Lateral Thalamic Nuclei / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology*; D010812:Physical Stimulation; D020656:Posterior Thalamic Nuclei / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D012782:Shoulder / Q000502:physiology; D020651:Ventral Thalamic Nuclei / Q000502:physiology*