Exiguamide, a new spirocyclic sesquiterpene from the marine sponge Geodia exigua that inhibits cell fate specification during sea urchin embryogenesis.
A new nitrogen-containing bicyclic spirosesquiterpene designated exiguamide which inhibited cell fate specification during sea urchin embryogenesis has been isolated from the marine sponge Geodia exigua. Its structure was determined by interpretation of spectral data and X-ray crystallographic analysis.
Uy
Mylene M
MM
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
Ohta
Shinji
S
Yanai
Mihoko
M
Ohta
Emi
E
Hirata
Toshifumi
T
Ikegami
Susumu
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D018360:Crystallography, X-Ray; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects; D047108:Embryonic Development; D007814:Larva; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010063:Ovum / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D011161:Porifera / Q000737:chemistry*; D012617:Sea Urchins; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D012717:Sesquiterpenes; D013141:Spiro Compounds; C471976:exiguamide