Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES).
Experimental animal and clinical studies have well established the association of prenatal exposure to diethylstilbestrol (DES) and the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia. Overwhelmingly, the focus has been on DES-induced epithelial lesions, particularly vaginal adenosis and adenocarcinoma; however, uterine smooth muscle cells are also recognized as cellular targets of DES. This descriptive report characterizes uterine leiomyomas that occur in outbred CD-1 mice following exposure to DES prenatally on days 9 to 16 of gestation or on neonatal days 1 to 5. These DES-induced uterine leiomyomas have typical histomorphologic, and some immunohistochemical characteristics of spontaneously occurring uterine smooth muscle tumors of B6C3F1 mice previously described in our laboratory, and they are also similar to uterine leiomyomas (fibroids) commonly observed in premenopausal women.
Newbold
Retha R
RR
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Moore
Alicia B
AB
Dixon
Darlene
D
D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D007150:Immunohistochemistry; D007279:Injections, Subcutaneous; D007889:Leiomyoma / Q000139:chemically induced* / Q000737:chemistry / Q000473:pathology*; D018811:Maternal Exposure; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016211:Transforming Growth Factor alpha / Q000032:analysis; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000737:chemistry / Q000473:pathology*
D002273:Carcinogens; D018809:Proliferating Cell Nuclear Antigen; D016211:Transforming Growth Factor alpha; D004054:Diethylstilbestrol; D066246:ErbB Receptors