Transfusion-related alloimmune neutropenia: an undescribed complication of blood transfusion.
Alloimmune neutropenia in neonates is rare. We describe severe and persistent neutropenia in a 4-week-old neonate, which arose within 2 h of a transfusion of blood that contained about 28 mL of plasma and in which strong antibodies against human neutrophil antigen 1b (HNA-1b) were subsequently identified. The infant was positive for HNA-1b. No other likely cause of neutropenia was discovered. We believe this complication of blood transfusion to be a previously unrecognised one, and have called the condition transfusion-related alloimmune neutropenia (TRAIN).
Wallis
Jonathan P
JP
Freeman Hospital, NE7 7DN, Newcastle upon Tyne, UK. jonathan.wallis@tfh.nuth.northy.nhs.uk
Haynes
Simon
S
Stark
Gail
G
Green
Frances A
FA
Lucas
Geoff F
GF
Chapman
Cath E
CE
D001856:Bone Marrow Examination; D004804:Eosinophils; D005260:Female; D005838:Genotype; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D009000:Monocytes; D009503:Neutropenia / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009504:Neutrophils; D010298:Parity; D011247:Pregnancy; D017452:Receptors, IgG / Q000276:immunology; D013997:Time Factors; D065227:Transfusion Reaction
D017452:Receptors, IgG; D016179:Granulocyte Colony-Stimulating Factor