The kinetics of the removal of the N-methyltrityl (Mtt) group during the synthesis of branched peptides.
The purpose of this short communication is to describe the reaction rate for the removal of the N-methyltrityl (Mtt) protecting group that is used in solid-phase peptide synthesis for the production of branched and cyclic peptides. The reaction rate was observed to follow zero-order kinetics, and we suggest the optimal conditions for the removal of the Mtt group in batchwise synthesis.
Li
D
D
Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Elbert
D L
DL
D007700:Kinetics; D013058:Mass Spectrometry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013053:Spectrophotometry; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
D010455:Peptides; D014320:Triphenylmethyl Compounds