title: ATP and control of intracellular growth of mycobacteria by T cells.
abstract: Extracellular ATP at millimolar concentrations inhibits growth of mycobacteria in human macrophages. Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes.
authors.affiliation: Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44109, USA. dxc44@cwru.edu
authors.forename: David H
authors.initials: DH
authors.lastname: Canaday
authors.forename: Reza
authors.initials: R
authors.lastname: Beigi
authors.forename: Richard F
authors.initials: RF
authors.lastname: Silver
authors.forename: Clifford V
authors.initials: CV
authors.lastname: Harding
authors.forename: W Henry
authors.initials: WH
authors.lastname: Boom
authors.forename: George R
authors.initials: GR
authors.lastname: Dubyak
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology*; D015550:Cell Degranulation; D002460:Cell Line; D006801:Humans; D009000:Monocytes / Q000502:physiology; D009163:Mycobacterium bovis / Q000254:growth & development*; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D000255:Adenosine Triphosphate