A concise, asymmetric synthesis of tetramic acid derivatives.
[reaction: see text] A simple, asymmetric synthesis of tetramic acid derivatives is described in this paper. The key step is a carbonyl transfer from carbonyldiimidazole (CDI) to alpha-diimines (I) to form N-alkyl-4-alkylamino-5-methylenepyrrol-2-ones (II). In turn, these compounds can be easily transformed into tetramic acid derivatives (III) in two additional steps.
Fustero
Santos
S
Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain. santos.fustero@uv.es
García de la Torre
Marta
M
Sanz-Cervera
Juan F
JF
Ramírez de Arellano
Carmen
C
Piera
Julio
J
Simón
Antonio
A