title: Evaluation of tissue factor antigen level in human seminal plasma.
abstract: We measured the seminal plasma levels of tissue factor (TF) and interleukin-6 (IL-6) in men and examined their relationship with sperm concentration and motility. The study comprised 71 patients in three groups: an infertile group with ( n=11) and without ( n=50) leukocytospermia and a fertile group ( n=10). The seminal plasma levels of TF were significantly higher in the infertile patients than in the fertile ones. The seminal plasma levels of both TF and IL-6 were significantly higher in the infertile patients with leukocytospermia than in those without leukocytospermia. In 54 nonazoopermic cases the seminal plasma levels of TF were significantly correlated with the sperm concentration and sperm motility. Further studies are necessary to clarify the role of TF in human fertilization.
authors.affiliation: Department of Urology, Faculty of Medicine, Toyama Medical and Phamaceutical University, Toyama, Japan. d11494@mail.goo.ne.jp
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ohta
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Esteban C
authors.initials: EC
authors.lastname: Gabazza
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
authors.forename: Hideki
authors.initials: H
authors.lastname: Fuse
mesh_terms: D000328:Adult; D005298:Fertility / Q000502:physiology*; D006801:Humans; D007248:Infertility, Male / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015850:Interleukin-6 / Q000032:analysis; D007964:Leukocytosis / Q000209:etiology; D008297:Male; D012661:Semen / Q000737:chemistry* / Q000166:cytology; D013076:Sperm Count; D013081:Sperm Motility; D013925:Thromboplastin / Q000032:analysis*
chemical_list: D015850:Interleukin-6; D013925:Thromboplastin