Stiff-person syndrome associated with oral isotretinoin treatment.
We describe a patient with severe nodulocystic acne who developed disabling muscle stiffness and painful superimposed spasms of the neck, back and upper limbs 10 days after the onset of oral isotretinoin treatment. The muscle hyperactivity condition, which revealed the clinical and electromyographic features of the stiff-person syndrome, gradually resolved 2 weeks after drug withdrawal.
Chroni
E
E
Department of Neurology, School of Medicine, University of Patras, P.O. Box 1045, Rio, 26500, Patras, Greece. echroni@yahoo.com
Sakkis
Th
T
Georgiou
S
S
Monastirli
A
A
Pasmatzi
E
E
Paschalis
C
C
Tsambaos
D
D
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004576:Electromyography / Q000187:drug effects; D005500:Follow-Up Studies; D018757:GABA Modulators / Q000627:therapeutic use; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D016750:Stiff-Person Syndrome / Q000139:chemically induced*
D003879:Dermatologic Agents; D018757:GABA Modulators; D005968:Glutamate Decarboxylase; D015474:Isotretinoin; D003975:Diazepam