title: The Arabidopsis RRS1-R disease resistance gene--uncovering the plant's nucleus as the new battlefield of plant defense?
abstract: The isolation of over 30 plant disease-resistance genes revealed that most genes encode putatively cytoplasmic proteins with a nucleotide-binding site (NBS) and a leucine-rich repeat (LRR). However, the recent isolation of the Arabidopsis RRS1-R gene has uncovered a novel NBS-LRR subtype that harbors a C-terminal extension with a putative nuclear localization signal and a DNA-binding domain that is characteristic of the WRKY transcription factor family. This suggests that RRS1-R, unlike any other known R protein, is targeted to the nucleus to fulfill its function.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lahaye
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D016946:Gram-Negative Aerobic Rods and Cocci / Q000254:growth & development; D007113:Immunity, Innate / Q000235:genetics; D010935:Plant Diseases / Q000235:genetics* / Q000382:microbiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; C118837:EDS1 protein, Arabidopsis; C109369:NDR1 protein, Arabidopsis; D014157:Transcription Factors