[An in vitro study of tracheal smooth muscle response to ethanol in neonates with respiratory distress syndrome].
The aim of this paper was the registration of the answers of the smooth musculature of the trachea at the different concentrations of ethanol, at the gestationary weeks of the newborns with the respiratory distress syndrome. In vitro examination was worked at the nonhuman preparations of the trachea of the newborns at autopsy material, the same material of the trachea and the lungs is fixed on 10% puferized formaline for the pathomorphologic examinations (RDS). The incubation of the preparation is performed on the water bath with Kreps solution, with the constant aerozation (O2 95% and CO2 5%). The answers are registered by means of the Transducer Statham UC2 at higher canal written physiography Watanabe HSE 6600. The preparations are treated with various concentrations of ethanol 96% (0.2 ml, 0.5 ml and 1.0 ml). From the received results we came to the conclusion that the effect of ethanol in the various concentrations at the smooth musculature of the trachea in the newborns with RDS, is demonstrated the contractile or the relaxing effect without statistic significance in various gestational weeks (p > 0.05).
Shabani
R
R
Institut za patologiju, farmakologiju, klinicku fiziologiju i sudsku medicinu, UKC Medicinski fakultet Pristina.
Islami
H
H
Haliti
N
N
Qehaja
N
N
Ahmetaj
H
H
Jakupi
M
M
Sopa
R
R
Gashi-Luci
L
L
Gashi-Naka
S
S
D000431:Ethanol / Q000494:pharmacology*; D005865:Gestational Age; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000503:physiopathology; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*; D014132:Trachea / Q000187:drug effects* / Q000503:physiopathology
D000431:Ethanol