Somatic cell nuclear transfer.
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
Wilmut
I
I
Roslin Institute, Roslin, Midlothian EH25 9PS, UK. ian.wilmut@bbsrc.ac.uk
Beaujean
N
N
de Sousa
P A
PA
Dinnyes
A
A
King
T J
TJ
Paterson
L A
LA
Wells
D N
DN
Young
L E
LE
D000818:Animals; D002417:Cattle; D002453:Cell Cycle; D002454:Cell Differentiation; D019976:Cloning, Organism; D005314:Embryonic and Fetal Development; D005313:Fetal Death; D005544:Forecasting; D018507:Gene Expression Regulation, Developmental; D006041:Goats; D051379:Mice; D053652:Nuclear Transfer Techniques; D009865:Oocytes / Q000166:cytology; D011003:Ploidies; D012756:Sheep; D013552:Swine