title: Vitronectin receptor alpha(V)beta(3) integrin antagonists: chemical and structural requirements for activity and selectivity.
abstract: Alpha(V)beta(3) integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.
authors.affiliation: Groupe SUCRES, Unité Mixte 7565 CNRS, Université Henri Poincaré-Nancy 1, BP 239, F-54506 Nancy-Vandoeuvre, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Henry
authors.forename: Nicolas
authors.initials: N
authors.lastname: Moitessier
authors.forename: Yves
authors.initials: Y
authors.lastname: Chapleur
mesh_terms: D001569:Benzodiazepines / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D039302:Integrin alphaVbeta3 / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D039302:Integrin alphaVbeta3; D010456:Peptides, Cyclic; D001569:Benzodiazepines