title: Antimicrobial resistance in Haemophilus influenzae isolated during population-based surveillance for meningitis in Salvador, Brazil.
abstract: Antimicrobial susceptibility was determined for 150 Haemophilus influenzae isolates obtained during population-based surveillance for meningitis in Salvador, Brazil. Ten (6.7%) isolates were resistant to ampicillin and chloramphenicol. Of these, two isolates, a beta-lactamase and non-beta-lactamase producer, were resistant to amoxacillin-clavulinic acid. These findings indicate that present antibiotic regimens in Brazil may not be appropriate for the treatment of H. influenzae meningitis.
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde. Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
authors.forename: Joice Neves
authors.initials: JN
authors.lastname: Reis
authors.forename: Josilene Borges
authors.initials: JB
authors.lastname: Lima
authors.forename: Guilherme Souza
authors.initials: GS
authors.lastname: Ribeiro
authors.forename: Soraia Machado
authors.initials: SM
authors.lastname: Corderio
authors.forename: Kátia
authors.initials: K
authors.lastname: Salgado
authors.forename: Mitermayer Galvão
authors.initials: MG
authors.lastname: Reis
authors.forename: Albert I
authors.initials: AI
authors.lastname: Ko
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D018073:Haemophilus Vaccines / Q000191:economics / Q000627:therapeutic use; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D018073:Haemophilus Vaccines; D019980:Amoxicillin-Potassium Clavulanate Combination; D001618:beta-Lactamases