[Effect of angiotensin-converting enzyme inhibitors on serum levels of erythropoietin in patients on peritoneal dialysis].
OBJECTIVE
To assess the effect of angiotensin-converting enzyme inhibitors (ACEI) on the serum level of erythropoietin (EPO) in patients receiving peritoneal dialysis and explore the possible mechanism.


METHODS
Thirty-six patients receiving peritoneal dialysis were enrolled in this study, among whom 26 received EPO treatment and the other 10 did not. The 2 groups were randomly subdivided into experimental group and control group with equal cases in each, the former with ACEI prescription to control blood pressure while the latter with calcium channel blocker or alpha-receptor blocker. Serum levels of EPO and hemoglobin (Hb) in all the patients were determined before and 6 months after their respective therapies.


RESULTS
The serum levels of EPO and Hb decreased significantly after therapy in the experimental group (P<0.05), obviously lower than those in the control group (P<0.05).


CONCLUSIONS
ACEI may decrease the serum EPO and Hb levels in patients receiving peritoneal dialysis.
Huang
Yuan-Hang
YH
Department of Nephrology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D004921:Erythropoietin / Q000097:blood*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010530:Peritoneal Dialysis; D051437:Renal Insufficiency / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D006454:Hemoglobins; D004921:Erythropoietin