title: NF-kappaB activity decreases in basal forebrain of young and aged rats after hyperoxia.
abstract: Hyperoxia is an oxidative stressor that triggers signaling cascades via changes in promoter activation by transcription factors. The transcription factor NF-kappaB has been shown to regulate transcription of many genes that play a role in inflammation and recovery from acute or chronic trauma. Here we describe the effects of hyperoxia on basal levels of NF-kappaB activity in young and aged rat forebrain. The results would suggest that chronic stress may have different effects on NF-kappaB basal activity levels as compared to the effects of an acute stress such as hyperoxia and that there is a diminished response to hyperoxia in the aged basal forebrain.
authors.affiliation: Department of Anesthesiology, University Texas Medical Branch, Galveston, TX 77555-0652, USA.
authors.forename: Tracy
authors.initials: T
authors.lastname: Toliver-Kinsky
authors.forename: David
authors.initials: D
authors.lastname: Rassin
authors.forename: J Regino
authors.initials: JR
authors.lastname: Perez-Polo
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D018496:Hyperoxia / Q000378:metabolism*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*; D052002:NF-kappa B p50 Subunit; D018384:Oxidative Stress / Q000502:physiology; D010100:Oxygen / Q000097:blood; D016548:Prosencephalon / Q000378:metabolism*; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D051996:Transcription Factor RelA
chemical_list: D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D051996:Transcription Factor RelA; D010100:Oxygen