Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex.
In a yeast two-hybrid screen using the Drosophila Axin protein as a bait, we have identified a Drosophila homolog of CAP, a component of the glucose transport regulatory complex. Through alternative splicing, the DCAP gene generates a set of five different proteins with unique N-terminal sequences and a common C-terminal SH3 domain. DCAP is predominantly expressed in the midgut and fat bodies of late-stage embryos, suggesting a role in insulin-mediated glucose transport in these organs.
Yamazaki
Hiroto
H
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nusse
Roel
R
D017398:Alternative Splicing; D000818:Animals; D001692:Biological Transport; D015152:Blotting, Northern; D015153:Blotting, Western; D018076:DNA, Complementary / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000096:biosynthesis* / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D017403:In Situ Hybridization; D009004:Monosaccharide Transport Proteins / Q000096:biosynthesis* / Q000235:genetics*; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction; D020798:Two-Hybrid System Techniques; D018909:src Homology Domains
C475445:CAP protein, Drosophila; D018076:DNA, Complementary; D029721:Drosophila Proteins; D009004:Monosaccharide Transport Proteins; D012333:RNA, Messenger; D005982:Glutathione Transferase; D005947:Glucose