[Role of angiotensin in the metabolic syndrome and cardiovascular complications].
Angiotensin II is known to inhibit the insulin-signaling pathway. On the other hand, insulin causes activation of the cardiovascular renin-angiotensin system in both cardiac cells and vascular cells(smooth muscle cells and endothelial cells). Insulin-activated tissue renin-angiotensin system leads to increased cell growth and contributes to cardiac hypertrophy and atherosclerosis. The fact that agents that inhibit the renin-angiotensin system also block insulin-mediated renin-angiotensin system expression and cell growth reinforces the potential implication of a cardiovascular insulin-renin-angiotensin system pathway. This review examines the mechanisms that connect systemic insulin resistance to the cardiovascular complications in the metabolic syndrome, especially the relation between insulin-signaling pathway and angiotensin.
Rakugi
Hiromi
H
Department of Geriatric Medicine, Osaka University Graduate School of Medicine.
Ogihara
Toshio
T
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D009206:Myocardium / Q000166:cytology; D012084:Renin-Angiotensin System / Q000502:physiology*