Treating preterm infants at risk for chronic lung disease with dexamethasone leads to an impaired quality of general movements.
Mortality rates do not decline markedly after postnatal corticosteroid therapy and concern has been raised about its neurological sequelae. We studied 37 preterm infants with Prechtl's method for the qualitative assessment of general movements before, during and after dexamethasone therapy and found that the quality of general movements was impaired in 9 of 13 initially normal infants (p = 0.004, McNemar test). The quality of fidgety movements at 3 months was abnormal in the majority of the infants and correlated strongly with neurological abnormalities at 2 years (Spearman r = 0.785, p < 0.001). Prechtl's method may prove useful for the early neurological evaluation of alternative corticosteroid treatment strategies for the treatment of chronic lung disease.
Bos
Arend F
AF
Department of Paediatrics, Division of Neonatology, University Hospital, Beatrix Children's Hospital, Groningen, The Netherlands. a.f.bos@med.rug.nl
Dibiasi
Jasmin
J
Tiessen
Ansje H
AH
Bergman
Klasien A
KA
D002908:Chronic Disease; D003907:Dexamethasone / Q000009:adverse effects* / Q000627:therapeutic use; D004453:Echoencephalography; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008171:Lung Diseases / Q000517:prevention & control*; D009069:Movement Disorders / Q000209:etiology*; D012307:Risk Factors
D005938:Glucocorticoids; D003907:Dexamethasone