Protein expression of NF-kappaB in human colorectal adenocarcinoma.
NF-kappaB is a transcription factor believed to mediate a cellular survival response following the apoptotic stimulus TNF-alpha. To clarify the role of NF-kappaB in colorectal cancer, we investigated the relationship of NF-kappaB expression by immunohistochemistry with clinicopathological variables, and other factors including apoptotic index, bcl-2 expression, p53 and K-ras mutations in 138 colorectal adenocarcinomas. Eighty-seven (63%) tumours showed cytoplasmic and 51 (37%) nuclear NF-kappaB expression. Nuclear NF-kappaB was correlated with mucinous carcinomas (p=0.006) and was more apparent in the invasive margin of some tumours. A trend was seen between nuclear NF-kappaB expression and K-ras mutation (p=0.15). However, NF-kappaB was not correlated with gender, age, tumour location, Dukes' stage, survival, apoptotic index, bcl-2 expression and p53 mutations. Conclusively, NF-kappaB might be activated in more aggressive colorectal tumour cells, since both tumour cells in the invasive margin and the mucinous tumour cells could represent more aggressive tumour cells.
Evertsson
Sofia
S
Department of Oncology, Institute of Biomedicine and Surgery, Linköping University, S-581 85 Linköping, Sweden. sofev@ibk.liu.se
Sun
Xioa-Feng
XF
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016328:NF-kappa B / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
D016328:NF-kappa B; D019253:Proto-Oncogene Proteins c-bcl-2