Non-genomic effects of steroid hormones on membrane channels.
Steroid hormones may possess two distinct actions, a delayed genomic influence and the rapid nongenomic effects, which may act in concert. Nongenomic effect may be mediated by putative membrane receptors or due to allosteric interactions of steroids with membrane proteins (e.g. ionic channels), inducing rapid changes in protein/receptor/channel activation or inhibition.
Hervé
J C
JC
Laboratoire de Physiologie Cellulaire, UMR CNRS-Université de Poitiers 6558, 40 avenue du R. Pineau, France. Jean.Claude.Herve@univ-poitiers.fr
D000494:Allosteric Regulation; D000818:Animals; D015195:Drug Design; D006801:Humans; D007473:Ion Channels / Q000187:drug effects*; D011956:Receptors, Cell Surface / Q000187:drug effects; D013256:Steroids / Q000494:pharmacology* / Q000502:physiology
D007473:Ion Channels; D011956:Receptors, Cell Surface; D013256:Steroids