title: Carcinogenic and endocrine disrupting effects of cigarette smoke and risk of breast cancer.
abstract: BACKGROUND
  Results of epidemiological studies, assessing the relation between smoking and breast cancer, have been inconclusive. Our aim was to assess the carcinogenic and possibly antioestrogenic effects of cigarette smoke on risk of breast cancer.
  
  
  METHODS
  We sent a questionnaire to 1431 women younger than age 75 years who had breast cancer and were listed on the population-based British Columbia cancer registry between June 1, 1988, and June 30, 1989. We also sent questionnaires to 1502 age-matched controls, randomly selected from the 1989 provincial voters list. We obtained information on all known and suspected risk factors for breast cancer, and on lifetime smoking, alcohol consumption, and occupational history. We assessed the effect of smoking separately for premenopausal and postmenopausal women, adjusting for confounding variables.
  
  
  RESULTS
  318 premenopausal women and 340 controls replied. Risk of breast cancer was significantly increased (adjusted odds ratio 1.69, 95% CI 1.13-2.51) in women who had been pregnant and who started to smoke within 5 years of menarche, and in nulliparous women who smoked 20 cigarettes daily or more (7.08, 1.63-30.8) and had smoked for 20 cumulative pack-years or more (7.48, 1.59-35.2). Postmenopausal women (700 breast cancer and 685 controls) whose body-mass index increased from age 18 to current and who started to smoke after a first fullterm pregnancy had a significantly reduced risk of breast cancer (0.49, 0.27-0.89).
  
  
  CONCLUSIONS
  Our results suggest that cigarette smoke exerts a dual action on the breast, with different effects in premenopausal and postmenopausal women. Our observations reinforce the importance of smoking prevention, especially in early adolescence, and draw attention to the timing of exposure in relation to susceptibility and refractory windows in the design of studies to investigate associations between environmental carcinogens or putative endocrine disruptors and risk of breast cancer.
authors.affiliation: Health Canada, 1001 Saint-Laurent O, Québec J4K 1C7, Longueuil, Canada. pierre_band@hc-sc.gc.ca
authors.forename: Pierre R
authors.initials: PR
authors.lastname: Band
authors.forename: Nhu D
authors.initials: ND
authors.lastname: Le
authors.forename: Raymond
authors.initials: R
authors.lastname: Fang
authors.forename: Michèle
authors.initials: M
authors.lastname: Deschamps
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D001955:British Columbia / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D011159:Population Surveillance; D017698:Postmenopause; D017697:Premenopause; D012042:Registries; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D000074606:Smoking Prevention; D011795:Surveys and Questionnaires