title: ECG-gated multi-detector row CT for assessment of mitral valve disease: initial experience.
abstract: Our objective was to evaluate applicability and image quality of contrast-enhanced, retrospectively ECG-gated multi-detector row CT (MDCT) for visualization of anatomical details of the mitral valve and its apparatus, and to determine the value of MDCT for diagnosing abnormal findings of the mitral valve. Twenty consecutive patients with mitral valve disease underwent MDCT preoperatively. Two readers assessed visibility of the mitral valve annulus, mitral valve leaflets, tendinous cords, and papillary muscles by using a four-point Likert grading scale. Abnormal mitral valve findings [thickening of the mitral valve leaflets, presence of mitral annulus calcification (MAC), and calcification of the valvular leaflets] were compared with preoperative echocardiography and intraoperative findings. Visibility of the mitral valve annulus and mitral valve leaflets was good or excellent in 15 patients (75%) and in 19 patients (95%) for papillary muscles. The MDCT yielded a 95-100% agreement compared with echocardiography and surgery with regard to the assessment of mitral valve leaflet thickening and the presence of calcifications of the mitral valve annulus or mitral valve leaflets. Intermodality agreement between MDCT and echocardiography was excellent with regard to classification of mitral valve leaflet thickness (kappa=1.00) and good regarding classification of MAC thickness (kappa=0.73). Contrast-enhanced, retrospectively ECG-gated MDCT allows good to excellent visualization of anatomical details of the mitral valve and its apparatus, and demonstrates good agreement with echocardiography and surgery in diagnosing mitral valve abnormalities.
authors.affiliation: Institute of Diagnostic Radiology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
authors.forename: Jürgen K
authors.initials: JK
authors.lastname: Willmann
authors.forename: Richard
authors.initials: R
authors.lastname: Kobza
authors.forename: Justus E
authors.initials: JE
authors.lastname: Roos
authors.forename: Mario
authors.initials: M
authors.lastname: Lachat
authors.forename: Rolf
authors.initials: R
authors.lastname: Jenni
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hilfiker
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Lüscher
authors.forename: Borut
authors.initials: B
authors.lastname: Marincek
authors.forename: Dominik
authors.initials: D
authors.lastname: Weishaupt
mesh_terms: D003287:Contrast Media; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000000981:diagnostic imaging* / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media