title: Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome.
abstract: Glioblastoma of the brain stem is rare and there is no description of such a lesion in patients suffering from acquired immunodeficiency syndrome. The majority of intracerebral mass lesions are due either to toxoplasmosis or primary central nervous system lymphomas so that it is usually not included in the differential diagnosis of enhancing lesions of the central nervous system in these patients. A 31-year-old human immunodeficiency virus (HIV) infected man presented with a four months history of slowly progressive deterioration of brainstem associated symptoms despite antitoxoplasmic therapy. Magnetic resonance imaging revealed a large ring enhancing lesion in the brainstem. Clinical and neuroradiological data could not establish a proper diagnosis and a stereotactic serial biopsy was undertaken. Histological examination of the specimen showed a glioblastoma multiforme (GBM) as the first reported case of GBM located in the brainstem in an acquired immunodeficiency syndrome (AIDS) patient. Patient management and effectiveness of stereotactic serial biopsy are discussed.
authors.affiliation: Neurosurgical Clinic, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Wolff
authors.forename: M
authors.initials: M
authors.lastname: Zimmermann
authors.forename: Gerhard
authors.initials: G
authors.lastname: Marquardt
authors.forename: H
authors.initials: H
authors.lastname: Lanfermann
authors.forename: R
authors.initials: R
authors.lastname: Nafe
authors.forename: V
authors.initials: V
authors.lastname: Seifert
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D001706:Biopsy / Q000295:instrumentation; D020295:Brain Stem Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004867:Equipment Design; D005909:Glioblastoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000295:instrumentation; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D038361:Neuronavigation / Q000295:instrumentation; D011149:Pons / Q000473:pathology; D013238:Stereotaxic Techniques / Q000295:instrumentation; D014057:Tomography, X-Ray Computed / Q000295:instrumentation