Activity of GAR-936 and other antimicrobial agents against North American isolates of Staphylococcus aureus.
The comparative in vitro activity of GAR-936 and 12 other drugs against 602 North American isolates of methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus was determined. The GAR-936 MICs ranged from 0.06 to 1.0 mg/l. The MIC(50)s and MIC(90)s were 0.12 and 0.25 mg/l for MSSA and 0.25 and 0.5 mg/l for MRSA.
Low
Donald E
DE
Department of Microbiology, Toronto Medical Laboratories, Mount Sinai Hospital, Room 1487, 600 University Avenue, Toronoto, Ont, Canada M5G 1X5. dlow@mtsinai.on.ca
Kreiswirth
Barry N
BN
Weiss
Karl
K
Willey
Barbara M
BM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009656:North America; D013211:Staphylococcus aureus / Q000187:drug effects*; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline