title: Radical fragmentation of omega-bromoalkyl cyclobutanones. A modular approach to eight-membered carbocycles.
abstract: [reaction: see text] An eight-membered ring was conveniently appended onto a cycloalkene carboxylate by employing a facile radical cyclization-fragmentation reaction of an omega-bromoalkyl spirocyclobutanone, which was readily accessible by the Kulinkovich cyclopropanation and subsequent electrophilic addition to a 3-bromoalkyl acetal.
authors.affiliation: Department of Chemistry, University of Alabama, Tuscaloosa, Alabama 35487, USA.
authors.forename: Heong-Sub
authors.initials: HS
authors.lastname: Oh
authors.forename: Hyoung Ik
authors.initials: HI
authors.lastname: Lee
authors.forename: Jin Kun
authors.initials: JK
authors.lastname: Cha
mesh_terms: D000478:Alkylation; D001966:Bromine / Q000737:chemistry*; D002074:Butanones / Q000737:chemistry*; D008958:Models, Molecular
chemical_list: D002074:Butanones; D001966:Bromine