Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.
Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.
Baker
D A
DA
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston South Carolina 29425, USA. bakerda@musc.edu
Shen
H
H
Kalivas
P W
PW
D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003553:Cystine / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism*; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology; D020960:omega-Conotoxins / Q000494:pharmacology
D002121:Calcium Channel Blockers; D018765:Dopamine Uptake Inhibitors; D020960:omega-Conotoxins; D018698:Glutamic Acid; D013779:Tetrodotoxin; D003553:Cystine; D004110:Diltiazem; D003042:Cocaine