title: [Neuroimmune epidemiological value of reibergram in the first echovirus 16 meningoencephalitis outbreak in Cuba].
abstract: BACKGROUND
  During the third quarter of 2000, an outbreak of echovirus 16 meningoencephalitis was firstly occurred in Cuba and produced vomiting, headache, fever and exanthem that differentiate it from other enterovirus epidemies.
  
  
  OBJECTIVE
  To describe the intrathecal immunoglobulin synthesis pattern of the epidemie from the reibergram.
  
  
  METHODS
  Diagnostic serum and cerebrospinal fluid from 18 children during the acute phase by nephelometrie assay, besides cytochemical and virological study.
  
  
  RESULTS
  A predominant absence of intrathecal immunoglobulin synthesis and two patients with IgA and IgM synthesis was produced. 66% of cerebrospinal blood barrier dysfunction, 6.26 10 3 mean albumin ratio, lactate below 2.1 mmol/L and glucose concentration in cerebrospinal fluid was 50% over glucose blood content and 168 cells 10 6 L mainly lymphocytes were observed.
  
  
  CONCLUSIONS
  The intratecal immunoglobulin synthesis pattern differs from other enterovirus outbreaks that have affected this population and it seems the one found for the diagnostic period in adults. This finding alerts the possibility of genetic changes in echovirus 16 strain, interesting from the neuroimmunoepidemiological point of view.
authors.affiliation: Facultad de Ciencias Medicas Dr. Miguel Enriquez, La Habana, Cuba. adorta@infomed.sld.cu
authors.forename: A J
authors.initials: AJ
authors.lastname: Dorta-Contreras
authors.forename: H
authors.initials: H
authors.lastname: Reiber
authors.forename: M E
authors.initials: ME
authors.lastname: Magraner-Tarrau
authors.forename: B
authors.initials: B
authors.lastname: Weissbrick
authors.forename: M T
authors.initials: MT
authors.lastname: Interián-Morales
authors.forename: E
authors.initials: E
authors.lastname: Noris-García
authors.forename: X
authors.initials: X
authors.lastname: Escobar-Pérez
authors.forename: T
authors.initials: T
authors.lastname: González-Hernández
mesh_terms: D003462:Cuba / Q000453:epidemiology; D004196:Disease Outbreaks; D004457:Echovirus Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000134:cerebrospinal fluid*; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000276:immunology*
chemical_list: D007136:Immunoglobulins