Successful treatment of juvenile myelomonocytic leukemia relapsing after stem cell transplantation using donor lymphocyte infusion.
Juvenile myelomonocytic leukemia (JMML) is a rare pediatric malignancy. Hematopoietic stem cell transplantation (SCT) is the only curative approach. However, relapse after SCT remains the major cause of treatment failure. Unlike most other pediatric malignancies, JMML may be susceptible to a graft-versus-leukemia (GVL) effect, although, unlike chronic myeloid leukemia, reports of response to donor lymphocyte infusions (DLIs) remain scanty. This is the first report that describes the successful treatment of relapsed JMML with DLI in the absence of further chemotherapy and provides definite proof of a GVL effect in JMML.
Worth
Austen
A
Great Ormond Street Hospital for Children, London, United Kingdom.
Rao
Kanchana
K
Webb
David
D
Chessells
Judith
J
Passmore
Jane
J
Veys
Paul
P
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D020544:Graft vs Leukemia Effect; D006801:Humans; D007165:Immunosuppression Therapy; D007223:Infant; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000628:therapy*; D017710:Lymphocyte Transfusion; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D019172:Transplantation Conditioning