title: Evidence that nerve growth factor mediates the formation of sensory pericellular baskets in the rat trigeminal ganglion.
abstract: A role for nerve growth factor (NGF) in the remodeling of sensory neurons in the trigeminal ganglion was examined. Intracerebroventricular NGF infusion and/or bilateral removal of the sympathetic superior cervical ganglia, both of which are believed to increase the availability of NGF to primary sensory neurons, resulted in a significant increase in the frequency of calcitonin gene-related peptide immunoreactive pericellular baskets. The results of this study suggest that increased NGF is sufficient to enhance the formation of sensory baskets in this ganglion, and provide evidence that NGF may mediate the formation of sensory baskets in the sensory ganglia following injury.
authors.affiliation: Center for Neuroscience, Department of Zoology, Miami University, Oxford, OH 45056, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Shoemaker
authors.forename: L G
authors.initials: LG
authors.lastname: Isaacson
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000096:biosynthesis; D003574:Cytochrome c Group / Q000008:administration & dosage / Q000494:pharmacology; D003712:Dendrites / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D015171:Ganglionectomy; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D020932:Nerve Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D009473:Neuronal Plasticity; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D017783:Superior Cervical Ganglion; D012668:Trigeminal Ganglion / Q000187:drug effects* / Q000378:metabolism
chemical_list: D003574:Cytochrome c Group; D020932:Nerve Growth Factor; D015740:Calcitonin Gene-Related Peptide