[Angiotensin II receptor antagonist improves age-related impairment of EDHF-mediated hyperpolarization].
Endothelium-dependent hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor(EDHF) diminish with aging as well as by hypertension. Antihypertensive treatment improved the endothelial dysfunction associated with hypertension. We here tested whether the angiotensin II receptor antagonist candesartan or the converting enzyme inhibitor enalapril would improve the age-related impairment of the EDHF-mediated responses in normotensive rats. EDHF-mediated hyperpolarization and relaxation to acetylcholine in mesenteric arteries were improved similarly in both candesartan- and enalapril-treated aged rats, but not in rats treated with the traditional combination of hydralazine and hydrochlorothiazide. These findings suggest that the inhibitors of renin-angiotensin system might serve as novel tools to prevent the endothelial dysfunction associated with aging.
Fujii
Koji
K
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
Abe
Isao
I
D000375:Aging / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use; D001685:Biological Factors / Q000378:metabolism*; D001713:Biphenyl Compounds; D004656:Enalapril / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D051381:Rats; D013777:Tetrazoles / Q000627:therapeutic use
D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles; D001685:Biological Factors; D001713:Biphenyl Compounds; D013777:Tetrazoles; C067410:endothelium-dependent hyperpolarization factor; D004656:Enalapril; C081643:candesartan