Liposomes for intravenous drug targeting: design and applications.
Drug targeting with liposomes has been studied for over 25 years and has demonstrated its value in clinical practice. This mini review offers an overview of the design and application of liposomes for i.v. drug targeting. Two approaches are outlined: passive and active targeting. The former approach is based on liposomes with prolonged circulation and selective target localization properties, while in the latter approach specific targeting ligands are coupled to the liposome surface in order to achieve enhanced interaction with target cell membranes.
Metselaar
J M
JM
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (IUPS), Utrecht University, PO Box 80.082, The Netherlands.
Mastrobattista
E
E
Storm
G
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D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D006801:Humans; D007275:Injections, Intravenous; D008024:Ligands; D008081:Liposomes / Q000008:administration & dosage / Q000493:pharmacokinetics*
D008024:Ligands; D008081:Liposomes