title: Effects of Chlorella vulgaris extract on cytokines production in Listeria monocytogenes infected mice.
abstract: In this study, we have investigated the effects of the unicellular-green-algae Chlorella vulgaris on the production of INF-gamma, IL-2, IL-4 and IL-10 in normal and Listeria monocytogenes infected mice. Our results demonstrated that in normal/non infected mice, CVE administration produced no effects in the levels of all cytokines studied. However, Listeria monocytogenes infection enhanced the production of INF-gamma and IL-2 at 48 and 72 h after the bacteria inoculation. Interestingly, the treatment with five consecutive doses of 50 mg/Kg/day of Chlorella vulgaris given previously to infection, led to further increases in INF-gamma and IL-2 levels at 48 and 72 h in relation to the presence of infection alone. No changes in IL-4 and IL-10 production were observed in Listeria monocytogenes and CVE treated/infected mice. These results are in accordance with the literature, which shows that CVE is a biological response modifier that enhances resistance to Listeria monocytogenes through augmentation of IL-2 and IFN-gamma.
authors.affiliation: Departamento de Farmacologia/Hemocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. msq44@uol.com.br
authors.forename: Mary L S
authors.initials: ML
authors.lastname: Queiroz
authors.forename: Claudia
authors.initials: C
authors.lastname: Bincoletto
authors.forename: Marize C
authors.initials: MC
authors.lastname: Valadares
authors.forename: Denise C M
authors.initials: DC
authors.lastname: Dantas
authors.forename: Leonilda M B
authors.initials: LM
authors.lastname: Santos
mesh_terms: D000818:Animals; D002708:Chlorella / Q000737:chemistry*; D016207:Cytokines / Q000096:biosynthesis*; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008088:Listeriosis / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D016753:Interleukin-10; D018664:Interleukin-12; D015847:Interleukin-4; D007371:Interferon-gamma