title: Anaerobic sugar catabolism in Lactococcus lactis: genetic regulation and enzyme control over pathway flux.
abstract: Lactic acid bacteria and particularly Lactococcus lactis are widely used for the production of lactic acid in fermented foods. Control of the catabolic rate in L. lactis, i.e., the rate of lactic acid production, appears to be determinant for dairy product quality. While the mechanisms involved in control have not been totally elucidated, they seem to depend upon the strain and the growth conditions. Furthermore, it remains unclear whether the catabolic rate is controlled at the level of transcription, translation or enzyme activity. The recent sequencing of the L. lactis genome has brought novel insights to physiologic studies of the bacteria. This review discusses both genetic information and metabolic studies concerning anaerobic sugar catabolism in L. lactis.
authors.affiliation: Laboratoire Biotechnologie Bioprocédés, UMR 5504 INSA/CNRS and UMR 792 INSA/INRA, Centre de Bioingénierie Gilbert Durand, Institut National des Sciences Appliquées, 31077 Toulouse Cedex 4, France. cocaign@insa-tlse.fr
authors.forename: Muriel
authors.initials: M
authors.lastname: Cocaign-Bousquet
authors.forename: Sergine
authors.initials: S
authors.lastname: Even
authors.forename: Nicolas D
authors.initials: ND
authors.lastname: Lindley
authors.forename: Pascal
authors.initials: P
authors.lastname: Loubière
mesh_terms: D000693:Anaerobiosis; D050260:Carbohydrate Metabolism; D005285:Fermentation; D005690:Galactose / Q000378:metabolism; D006019:Glycolysis; D019344:Lactic Acid / Q000378:metabolism; D013294:Lactococcus lactis / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D019289:Pyruvic Acid / Q000378:metabolism
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid; D005690:Galactose