title: Trends in consumption of calcium channel blockers in the Czech Republic during 1993-1999 and comparison with selected countries: drug utilization study.
abstract: OBJECTIVE
  To determine the patterns of consumption in calcium channel blockers (CCB) groups in the Czech Republic between 1992 and 1999 and make a comparison with selected countries.
  
  
  METHODS
  This was part of a drug utilization study using WHO methodology [Anatomical Therapeutic Chemical classification/defined daily doses (ATC/DDD)]. The wholesale data collected by drug distributors were used. Utilization was calculated as the DDDs for 1000 inhabitants per day. In focus was the consumption of short-acting nifedipine. Comparison with wholesale data from Finland, Norway, Germany and Australia was made.
  
  
  RESULTS
  There was a decreasing tendency to use short-acting nifedipine in the Czech Republic over the period 1993-1999. Four years after publication of warning evidence, short-acting nifedipine still accounted for 23% of all calcium channel blockers in our country. The abundance of second-generation CCBs increased from less than 1% in 1993 to 43% in 1999. The consumption of short-acting nifedipine in the Czech Republic and Germany is probably three times more frequent than in Nordic countries and Australia.
  
  
  CONCLUSIONS
  Consumption of short-acting nifedipine in the Czech Republic 4 years after recognition of its risks still remains very high. This suggests that implementation of clinical trial results to clinical practice is very slow and ineffective.
authors.affiliation: Department of Pharmacology, 3rd Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 34, Czech Republic. tomas.dolezal@lf3.cuni.cz
authors.forename: Tomas
authors.initials: T
authors.lastname: Dolezal
authors.forename: Karel
authors.initials: K
authors.lastname: Nemecek
authors.forename: Miloslav
authors.initials: M
authors.lastname: Krsiak
mesh_terms: D002121:Calcium Channel Blockers; D018153:Czech Republic / Q000453:epidemiology; D017723:Drug Utilization Review; D019317:Evidence-Based Medicine; D006801:Humans; D009543:Nifedipine; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data* / Q000639:trends
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine