title: Olprinone: a phosphodiesterase III inhibitor with positive inotropic and vasodilator effects.
abstract: Olprinone is a newly developed phosphodiesterase III inhibitor characterized by several properties. First, olprinone has positive inotropic and vasodilator actions and improves myocardial mechanical efficiency. Second, olprinone augments cerebral blood flow by a direct vasodilatory effect on cerebral arteries. The cerebrovascular reactivity to olprinone is marked in patients with impaired cerebral circulation. Third, olprinone selectively improves carotid artery distensibility, which may be attributable to differences in the arterial structural components or the reactivity of smooth muscle cells to olprinone. Fourth, olprinone improves inadequate redistribution of brain perfusion and may prevent cerebral metabolic abnormalities in heart failure.
authors.affiliation: Second Department of Internal Medicine, Kagawa Medical University, 1750-1, Miki, Kita Kagawa 761-0793, Japan. katsumz@kms.ac.jp.
authors.forename: Katsufumi
authors.initials: K
authors.lastname: Mizushige
authors.forename: Takashi
authors.initials: T
authors.lastname: Ueda
authors.forename: Kazushi
authors.initials: K
authors.lastname: Yukiiri
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D002339:Carotid Arteries / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011728:Pyridones / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects
chemical_list: D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D011728:Pyridones; C059498:olprinone