[Heparin-induced extacorporeal low-density lipoprotein-lipoprotein alpha-fibrinogen precipitation in 36 cases].
OBJECTIVE
To observe the efficacy of heparin-induced extracorporeal low-density lipoprotein-lipoprotein alpha- fibrinogen precipitation (HELP) in clearing blood lipids.


METHODS
Thirty-six patients were subjected to extracorporeal plasma lipid separation procedures that utilized heparin to induce the formation of the complex consisted of heparin, low-density lipoprotein cholesterol (LDL-C), lipoprotein and fibrinogen which was precipitated and consequently separated from the plasma. Blood samples were obtained from the patients both before and after the procedures to assay serum total cholesterol (CH), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), LDL-C, apoliprotein A (ApoA) and apoliprotein B (ApoB).


RESULTS
Significant differences were observed between the pre- and postoperative levels of lipoprotein (P<0.001).


CONCLUSIONS
Plasma lipoprotein can be partly cleared by way of HELP.
Mo
Jian-Kun
JK
Clinical Laboratory,177th Hospital of Guangdong Province, Guangzhou 510310, China.
Li
Yong-Xin
YX
Lei
Da
D
Wu
De-Hai
DH
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001781:Blood Component Removal / Q000379:methods; D011232:Chemical Precipitation; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005112:Extracorporeal Circulation; D005260:Female; D005340:Fibrinogen / Q000187:drug effects / Q000378:metabolism*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D000925:Anticoagulants; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D005340:Fibrinogen; D006493:Heparin; D002784:Cholesterol