title: Cloning and expression of the surfeit locus member Surf-6 during embryogenesis in Xenopus laevis.
abstract: The Surf-6 gene, already characterized in fish (Fugu rubripes), mouse and man, is a member of the surfeit locus and encodes a nucleolar-matrix protein, which is ubiquitously expressed. This gene has been isolated in Xenopus laevis and shows high sequence similarity to its orthologues in other species. The putative protein is 342 amino acids long and several motifs are conserved, particularly a potential nuclear localization signal. During embryogenesis, after an initial decrease in the expression of the maternal Surf-6 RNA, the level increases to reach a maximum at hatching. The global level of the Surf-6 transcript at early neurula is enhanced by the overexpression of fli, a member of the ets gene family.
authors.affiliation: CNRS FRE 2168, Laboratoire des Mécanismes Moléculaires de la Division Cellulaire et du Développement, 15 rue René Descartes, 67084 Strasbourg, France. michel.wolff@ibmp-ulp.u-strasbg.fr
authors.forename: Charles-Michel
authors.initials: CM
authors.lastname: Wolff
authors.forename: Vu Khue
authors.initials: VK
authors.lastname: Nguyen
authors.forename: Pierre
authors.initials: P
authors.lastname: Remy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D018076:DNA, Complementary; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics*; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics
chemical_list: D018076:DNA, Complementary; D009687:Nuclear Proteins; D029867:Xenopus Proteins; C484379:surf6 protein, Xenopus