The stack of the golgi apparatus.
One hundred years have passed since the discovery of "the internal reticular apparatus" by Camillo GOLGI. Investigations into the structure and function of the "Golgi apparatus" have raised more and more challenging issues for cell biologists. After long debate, many new findings have accumulated in the last 10 years as a result of the availability of elegant new genetic, biochemical and morphological tools. This, in turn, has raised many new questions to be solved. In addition, numerous new findings have led to some confusion on the understanding of the Golgi apparatus. This review article deals with several modern aspects of vesicular transport versus cisternal maturation. Disruption of the stacked structure in mitotic and drug-induced conditions is also discussed to demonstrate the importance of structural integrity in the Golgi apparatus.
Tamaki
Hideaki
H
Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. tamaki@kitasato-u.ac.jp
Yamashina
Shohei
S
D000818:Animals; D020126:Brefeldin A / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000502:physiology / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000378:metabolism; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D008961:Models, Structural; D019319:Okadaic Acid / Q000494:pharmacology; D022161:Transport Vesicles / Q000502:physiology / Q000648:ultrastructure
D008565:Membrane Proteins; D019319:Okadaic Acid; D020126:Brefeldin A