Differential effects of carbamazepine on negatively versus positively reinforced responding.
To assess its effects on negatively versus positively reinforced operant behavior, carbamazepine (CBZ) or vehicle was acutely administered to rats. Negative reinforcement baselines consisted of a free-operant avoidance task with 5-s shock-shock and 20-s response-shock intervals. Positive reinforcement baselines consisted of responding for food pellets on a variable interval 30-s schedule. Ascending dose-effect functions were established using CBZ for negatively reinforced responding (vehicle, 25, 50, 100 mg/kg ip) and positively reinforced responding (vehicle, 12.5, 25, 50, 100 mg/kg ip). Negatively reinforced responses and avoided shocks were significantly reduced by CBZ injections at 100 mg/kg. Positively reinforced responses and food pellet deliveries were significantly reduced by CBZ injections at 25, 50, and 100 mg/kg. The results show that CBZ has differential, dose-dependent effects on negatively versus positively reinforced responding.
Caruso
Mary
M
Department of Human Development and Family Life and Institute for Child Development, University of Kansas, Lawrence, KS 66044, USA.
Harvey
Mark T
MT
Roberts
Celeste
C
Patterson
Tina G
TG
Kennedy
Craig H
CH
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001066:Appetite / Q000187:drug effects; D002220:Carbamazepine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012054:Reinforcement, Psychology
D000927:Anticonvulsants; D002220:Carbamazepine