Therapeutic applications of sugar-mimicking glycosidase inhibitors.
Sugar-mimicking alkaloids inhibit the glycosidases involved in a wide range of important biological processes, principally owing to their structural resemblance to the sugar moiety of the natural substrate. The possibility of modifying and blocking these processes by using such inhibitors for therapeutic applications has attracted a lot of attention.
Asano
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N
Faculty of Pharmaceudical Sciences, Hokuriku University, Kaanazawa, Japan. naoki22@po.incl.ne.jp
Kato
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Watson
A A
AA
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D000818:Animals; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000138:chemical synthesis* / Q000627:therapeutic use*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D006801:Humans; D008361:Mannosidases / Q000037:antagonists & inhibitors; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D000519:alpha-Galactosidase / Q000037:antagonists & inhibitors; D043323:alpha-Mannosidase
D004187:Disaccharides; D004791:Enzyme Inhibitors; D009844:Oligosaccharides; D017485:1-Deoxynojirimycin; D006026:Glycoside Hydrolases; D008361:Mannosidases; D000519:alpha-Galactosidase; D043323:alpha-Mannosidase; D005944:Glucosamine; C013626:nojirimycin