title: Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver.
abstract: According to the free radical theory of aging, oxygen-derived free radicals causes the age-associated impairment at the cellular and tissue levels. The mitochondrial theory of aging points to mitochondria, and specially mitochondrial DNA, as the major targets of free radical attack upon aging. Thus, oxidative damage to mtDNA accumulate with age in human and rodent tissues and also is inversely related to maximum life span of mammals. Mitochondrial deficits, such as a decrease in mitochondrial membrane potential, occur upon aging due to oxidative damage. The age-related mitochondrial oxidative stress may be prevented by late onset administration of certain antioxidants, such as Ginkgo biloba extract EGb 761. These antioxidants may also delay the physiological impairment associated with aging.
authors.affiliation: Departamento de Fisiologia, Facultad de Medicina, Universitat de València, Spain. juan.sastre@uv.es
authors.forename: Juan
authors.initials: J
authors.lastname: Sastre
authors.forename: Ana
authors.initials: A
authors.lastname: Lloret
authors.forename: Consuelo
authors.initials: C
authors.lastname: Borrás
authors.forename: Javier
authors.initials: J
authors.lastname: Pereda
authors.forename: David
authors.initials: D
authors.lastname: García-Sala
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Droy-Lefaix
authors.forename: Federico V
authors.initials: FV
authors.lastname: Pallardó
authors.forename: José
authors.initials: J
authors.lastname: Viña
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004249:DNA Damage / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism; D020441:Ginkgo biloba; D008928:Mitochondria / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D000096983:Ginkgo Extract
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D018696:Neuroprotective Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract