[Acquired and inherited hypercoagulability among patients with cerebral venous thrombosis].
BACKGROUND
Cerebral venous thrombosis (CVT) is considered to be a relative unusual pathology, probably underdiagnosed. Many acquired and inherited hypercoagulability states (HS) have been described as cause of CVT.


OBJECTIVE
[corrected] We evaluated the incidence of acquired and inherited thrombophilic risk factors in a population of CVT patients.


METHODS
Hypercoagulability studies were to carried out for patients suffering from radiologically confirmed CVT during a 3 year period (1998-2000). Prothrombin time, aPTT, protein C, protein S and antithrombin III activities, screening and confirmatory tests for lupus anticoagulant (LA), and activated protein C resistance (APCR) were tested. Genetic tests for G1691A factor V (Factor V Leiden), G20210A prothrombin and C677T methylentetrahidrofolate reductase (MTHFR) were performed. Computer database was used for descriptive statistics.


RESULTS
16 patients with CVT (M/F, 6/10) were screened for inherited and acquired coagulation disorders. Mean age of 23.66 years with standard desviation of 19.74 years. Two older patients had antecedents of thrombosis (ischemic stroke and deep-vein thrombosis in leg). We found 1 heterocygosis factor V Leiden associated to LA, 2 heterocygosis G20210A prothrombin (one associated to LA), 2 homocygosis C677T MTHFR, 1 hereditary antithrombin III deficiency and 4 LA.


CONCLUSIONS
Although this is a small series, we found a high incidence of hereditary (37.5%) and acquired (37.5%) thrombophilia in patients with CVT.
Sánchez-Martín
B
B
Servicios de Nurología, Hospital Universitario Miguel Servet. Zaragoza. España.
Grasa
J M
JM
Latorre
A
A
Montañés
M A
MA
García-Erce
J A
JA
Torres
M
M
Calvo
M T
MT
Giralt
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests; D002550:Cerebral Veins / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D019851:Thrombophilia / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology