[New total synthesis of derrusnine].
The thermal condensation of diethyl 3,4-methylenedioxyphenylmalonate with 3,5-dimethoxyphenol (di-O-methylphloroglucinol) leads to the corresponding 3-(3,4-méthylenedioxyphenyl)-4-hydroxy-5,7-dimethoxycoumarine which is methylated further into derrusnine.
Kirkiacharian
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Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud 5, rue Jean-Baptiste Clément, F92296 Chatenay-Malabry Cedex, France.
Chidiack
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Maïga
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Brion
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D015110:4-Hydroxycoumarins / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared
D015110:4-Hydroxycoumarins; D007202:Indicators and Reagents; C467831:derrusnine