[Paraneoplastic neurologic autoimmune diseases].
All complications of tumor disease that do not result from the tumor itself, its metastases, or vascular, infectious, metabolic, or therapy-related causes are referred to as paraneoplastic neurologic syndromes. This earlier represented an excluding diagnosis and the association was established only statistically, but since the first description of the anti-Hu antibody in 1985, we know that around 2/3 of patients with paraneoplastic disorders display highly specific antibody reactions in the serum. These reactions not only prove a paraneoplastic etiology in almost 100% of cases, but, due to their highly specific associations with certain tumor types, also aid tumor detection in patients whose tumor types are not known.
Voltz
R
R
Institut für Klinische Neuroimmunologie, Klinikum Grosshadern, München, Germany. rvoltz@nro.med.uni-muenchen.de
D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D020274:Autoimmune Diseases of the Nervous System / Q000175:diagnosis / Q000276:immunology*; D009420:Nervous System / Q000276:immunology; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000276:immunology*; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens