title: Increased plasma concentrations of interleukin-18 in acute coronary syndromes.
abstract: OBJECTIVE
  To examine the relation between plasma concentrations of interleukin-18 (IL-18), the interferon gamma inducing factor, and clinical instability of coronary artery disease.
  
  
  METHODS
  Observational study in a university hospital.
  
  
  METHODS
  11 patients with unstable angina and negative troponin I, 21 patients with acute non-Q wave myocardial infarction (MI), 21 patients with acute Q wave MI, 9 patients with stable angina, and 11 controls.
  
  
  METHODS
  Plasma IL-18 concentrations and their relation to clinical instability and myocardial dysfunction.
  
  
  RESULTS
  Plasma concentrations of IL-18 were significantly increased in the unstable angina and MI groups in comparison with the stable angina and control groups (p < 0.01). No difference in IL-18 concentrations were found between patients with unstable angina, patients with non-Q wave MI, and patients with Q wave MI. Plasma IL-18 concentrations significantly correlated with decreased left ventricular ejection fraction (p = 0.01).
  
  
  CONCLUSIONS
  Plasma IL-18 concentrations are increased in patients with acute coronary syndromes and correlate with the severity of myocardial dysfunction.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, INSERM U541, Hôpital Lariboisiére, 41, Bd de la Chapelle, 75475 Paris cedex 10, France. ziad.mallat@inserm.lrb.ap-hop-paris.fr
authors.forename: Z
authors.initials: Z
authors.lastname: Mallat
authors.forename: P
authors.initials: P
authors.lastname: Henry
authors.forename: R
authors.initials: R
authors.lastname: Fressonnet
authors.forename: S
authors.initials: S
authors.lastname: Alouani
authors.forename: A
authors.initials: A
authors.lastname: Scoazec
authors.forename: P
authors.initials: P
authors.lastname: Beaufils
authors.forename: Y
authors.initials: Y
authors.lastname: Chvatchko
authors.forename: A
authors.initials: A
authors.lastname: Tedgui
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000502:physiology; D013577:Syndrome
chemical_list: D015415:Biomarkers; D020382:Interleukin-18