Neural substrates of human facial expression of pleasant emotion induced by comic films: a PET Study.
Laughter or smile is one of the emotional expressions of pleasantness with characteristic contraction of the facial muscles, of which the neural substrate remains to be explored. This currently described study is the first to investigate the generation of human facial expression of pleasant emotion using positron emission tomography and H(2)(15)O. Regional cerebral blood flow (rCBF) during laughter/smile induced by visual comics and the magnitude of laughter/smile indicated significant correlation in the bilateral supplementary motor area (SMA) and left putamen (P < 0.05, corrected), but no correlation in the primary motor area (M1). In the voluntary facial movement, significant correlation between rCBF and the magnitude of EMG was found in the face area of bilateral M1 and the SMA (P < 0.001, uncorrected). Laughter/smile, as opposed to voluntary movement, activated the visual association areas, left anterior temporal cortex, left uncus, and orbitofrontal and medial prefrontal cortices (P < 0.05, corrected), whereas voluntary facial movement generated by mimicking a laughing/smiling face activated the face area of the left M1 and bilateral SMA, compared with laughter/smile (P < 0.05, corrected). We demonstrated distinct neural substrates of emotional and volitional facial expression and defined cognitive and experiential processes of a pleasant emotion, laughter/smile.
Iwase
Masao
M
Psychiatry, and Department of Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita-shi, Osaka 565-0871, Japan.
Ouchi
Yasuomi
Y
Okada
Hiroyuki
H
Yokoyama
Chihiro
C
Nobezawa
Shuji
S
Yoshikawa
Etsuji
E
Tsukada
Hideo
H
Takeda
Masaki
M
Yamashita
Ko
K
Takeda
Masatoshi
M
Yamaguti
Kouzi
K
Kuratsune
Hirohiko
H
Shimizu
Akira
A
Watanabe
Yasuyoshi
Y
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D016000:Cluster Analysis; D003071:Cognition / Q000502:physiology; D004576:Electromyography; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005152:Facial Muscles / Q000502:physiology; D005260:Female; D006801:Humans; D007845:Laughter / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed