title: Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp.
abstract: An anhydrophytosphingosine named pachastrissamine (3) has been isolated as a cytotoxic principle of a sponge, Pachastrissa sp., and the structure including the absolute configuration determined by spectroscopic and chemical analysis.
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
authors.forename: Ikuma
authors.initials: I
authors.lastname: Kuroda
authors.forename: Musri
authors.initials: M
authors.lastname: Musman
authors.forename: Ikuko I
authors.initials: II
authors.lastname: Ohtani
authors.forename: Toshio
authors.initials: T
authors.lastname: Ichiba
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
authors.forename: Dolores Garcia
authors.initials: DG
authors.lastname: Gravalos
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Higa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; C468594:pachastrissamine; D013110:Sphingosine