title: Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.
abstract: BACKGROUND
  The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. In mice, the amount of LRP activity was modulated by RAP, and RAP-null mice showed higher levels of total cholesterol.
  
  
  OBJECTIVE
  To evaluate the association between DNA polymorphisms at the LRP, LRPAP and alpha2 M genes and early myocardial infarction (MI).
  
  
  METHODS
  We genotyped 210 patients with early MI (<55 years) and 200 healthy control participants for three polymorphisms in the LRP, LRPAP and alpha2 M genes.
  
  
  RESULTS
  No association was found between these polymorphisms and plasma lipid levels in patients and control participants. Only the LRPAP-intron 1 polymorphism (a 21 bp insertion/deletion) was associated with MI (P = 0.0065; odds ratio = 2.18, 95% confidence intervals = 1.22-3.90).
  
  
  CONCLUSIONS
  According to our data, the variation at the LRPAP1 gene could contribute to the risk of developing an early episode of MI.
authors.affiliation: Laboratorio de Genética Molecular-Instituto de Investigación Nefrológica (IRSIN-FRIAT), Hospital Central Asturias, Oviedo, Spain.
authors.forename: Pelayo
authors.initials: P
authors.lastname: González
authors.forename: Ruth
authors.initials: R
authors.lastname: Alvarez
authors.forename: Julián R
authors.initials: JR
authors.lastname: Reguero
authors.forename: Alberto
authors.initials: A
authors.lastname: Batalla
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Arturo
authors.initials: A
authors.lastname: Cortina
authors.forename: Gustavo I
authors.initials: GI
authors.lastname: Cubero
authors.forename: Mónica
authors.initials: M
authors.lastname: García-Castro
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
mesh_terms: D000328:Adult; D006801:Humans; D007438:Introns / Q000235:genetics; D026563:LDL-Receptor Related Protein-Associated Protein / Q000235:genetics*; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D026563:LDL-Receptor Related Protein-Associated Protein; D026502:LDL-Receptor Related Proteins; D000511:alpha-Macroglobulins