title: The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription.
authors.affiliation: The Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Conaway
authors.forename: Joan W
authors.initials: JW
authors.lastname: Conaway
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000502:physiology; D015687:Cell Hypoxia / Q000235:genetics* / Q000502:physiology; D044842:Cullin Proteins; D000075065:Elongin; D004789:Enzyme Activation; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007680:Kidney Neoplasms / Q000378:metabolism; D008025:Ligases / Q000235:genetics / Q000502:physiology*; D046911:Macromolecular Substances; D009363:Neoplasm Proteins / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000502:physiology; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein
chemical_list: C105153:CUL2 protein, human; D018797:Cell Cycle Proteins; D044842:Cullin Proteins; D000075065:Elongin; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D046911:Macromolecular Substances; D009363:Neoplasm Proteins; D021122:Protein Subunits; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D011393:Procollagen-Proline Dioxygenase; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D008025:Ligases; C497446:VHL protein, human