Vitronectin receptor alpha(V)beta(3) integrin antagonists: chemical and structural requirements for activity and selectivity.
Alpha(V)beta(3) integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.
Henry
Christophe
C
Groupe SUCRES, Unité Mixte 7565 CNRS, Université Henri Poincaré-Nancy 1, BP 239, F-54506 Nancy-Vandoeuvre, France.
Moitessier
Nicolas
N
Chapleur
Yves
Y
D001569:Benzodiazepines / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D039302:Integrin alphaVbeta3 / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D039302:Integrin alphaVbeta3; D010456:Peptides, Cyclic; D001569:Benzodiazepines