Enantioselective alkylation of aldehydes with chiral organomagnesium amides (COMAs).
[reaction: see text] Dialkylmagnesiums react with chiral secondary amines to form chiral organomagnesium amides (COMAs). These reagents alkylate aldehydes to form secondary alcohols with enantioselectivities up to 91:9 er.
Yong
Kelvin H
KH
Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, (GWC)(2), and Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
Taylor
Nicholas J
NJ
Chong
J Michael
JM