Usefulness of CA19-9 versus CA125 for the diagnosis of endometriosis.
OBJECTIVE
To investigate the clinical value of the serum CA19-9 level in comparison with the serum CA125 level for diagnosing and determining the severity of endometriosis.


METHODS
Retrospective study.


METHODS
Department of Comprehensive Reproductive Medicine in a university hospital.


METHODS
One hundred one women with endometriosis and 22 without endometriosis participated in this study.


METHODS
Blood samples were collected before the operation (laparoscopy, oophrectomy, cystectomy, and/or hysterectomy), and tissue samples of ovarian chocolate cysts were collected during the operation.


METHODS
The serum CA19-9 and CA125 levels and the localization of these antigens in ovarian chocolate cysts.


RESULTS
The mean serum CA19-9 levels in patients at all stages of endometriosis were significantly higher than those in patients without endometriosis, and serum CA19-9 levels significantly correlated with the Revised American Fertility Society classification scores. Intense staining of CA19-9 was observed in 15 of the 20 samples of ovarian chocolate cysts.


CONCLUSIONS
CA19-9 is a useful marker for determining the severity of endometriosis.
Harada
Tatsuya
T
Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. t.harada.gyne@tmd.ac.jp
Kubota
Toshiro
T
Aso
Takeshi
T
D000328:Adult; D018394:CA-125 Antigen / Q000032:analysis / Q000097:blood*; D018395:CA-19-9 Antigen / Q000032:analysis / Q000097:blood*; D015653:Cystectomy; D004715:Endometriosis / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D010535:Laparoscopy; D008875:Middle Aged; D010048:Ovarian Cysts / Q000737:chemistry; D010052:Ovariectomy; D012044:Regression Analysis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D018394:CA-125 Antigen; D018395:CA-19-9 Antigen