Qualitative theory of compartmental systems with lags.
Dynamic models of many processes in the biological and physical sciences give systems of ordinary differential equations called compartmental systems. Often, these systems include time lags; in this context, continuous probability density functions (pdfs) of lags are far more important than discrete lags. There is a relatively complete theory of compartmental systems without lags, both linear and non-linear [SIAM Rev. 35 (1993) 43]. The authors extend their previous work on compartmental systems without lags to show that, for discrete lags and for a very large class of pdfs of continuous lags, compartmental systems with lags are equivalent to larger compartmental systems without lags. Consequently, the properties of compartmental systems with lags are the same as those of compartmental systems without lags. For a very large class of compartmental systems with time lags, one can show that the time lags themselves can be generated by compartmental systems without lags. Thus, such systems can be partitioned into a main system, which is the original system without the lags, plus compartmental subsystems without lags that generate the lags. The latter may be linear or non-linear and may be inserted into main systems that are linear or non-linear. The state variables of the compartmental lag subsystems are hidden variables in the formulation with explicit lags.
Jacquez
John A
JA
Department of Physiology, Center for the Study of Complex Systems, 4485 Randall Lab, The University of Michigan, Ann Arbor, MI 48109-1120, USA.
Simon
Carl P
CP
D001825:Body Fluid Compartments; D003198:Computer Simulation; D016014:Linear Models; D008954:Models, Biological; D008962:Models, Theoretical; D010599:Pharmacokinetics; D011336:Probability; D013997:Time Factors