title: Centriole duplication: centrin in on answers?
abstract: Many aspects of centriole biology remain mysterious. A new study has shed light on the role of the centriolar protein centrin-2: reducing levels of centrin-2 in HeLa cells has been found to block centriole duplication, eventually leading to cell death.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.
authors.forename: Luke M
authors.initials: LM
authors.lastname: Rice
authors.forename: David A
authors.initials: DA
authors.lastname: Agard
mesh_terms: D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology*; D016923:Cell Death; D002455:Cell Division; D002502:Centrioles / Q000502:physiology* / Q000648:ultrastructure*; D002868:Chromosomal Proteins, Non-Histone; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D034622:RNA Interference
chemical_list: D002135:Calcium-Binding Proteins; D002868:Chromosomal Proteins, Non-Histone; C056608:caltractin