title: An isorhapontigenin tetramer and a novel stilbene dimer from Gnetum hainanense.
abstract: The first isorhapontigenin tetramer, gnetuhainin R (1) and a novel dimeric stilbene, gnetuhainin S (2) were isolated from the lianas of Gnetum hainanense. Their structures were elucidated on the basis of spectroscopic and chemical evidence, especially 2D NMR analysis. The structure of 2 was further supported by X-ray crystallographic analysis. The anti-inflammatory activity of 1 has been tested, and it showed potent activity of histamine receptor antagonism.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Kai-Sheng
authors.initials: KS
authors.lastname: Huang
authors.forename: Shan
authors.initials: S
authors.lastname: Zhou
authors.forename: Mao
authors.initials: M
authors.lastname: Lin
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D035684:Gnetum; D006168:Guinea Pigs; D006632:Histamine; D007082:Ileum / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects*; D008517:Phytotherapy; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D013267:Stilbenes; C432307:isorhapontigenin; D006632:Histamine