Enhancement of use-dependent plasticity by D-amphetamine.
In healthy individuals, motor training can elicit use-dependent plasticity. Here the authors studied six subjects in whom training alone failed to elicit this effect. Administration of a single dose of 10 mg of D-amphetamine preceding training led to use-dependent plasticity in a subgroup of these subjects. Using pharmacologic interventions to enhance the effects of motor training might help rehabilitative efforts in patients in whom training alone fails.
Sawaki
L
L
Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
Cohen
L G
LG
Classen
J
J
Davis
B C
BC
Bütefisch
C M
CM
D000328:Adult; D000704:Analysis of Variance; D003913:Dextroamphetamine / Q000494:pharmacology*; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology; D005260:Female; D006225:Hand / Q000502:physiology; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000187:drug effects / Q000502:physiology; D009068:Movement / Q000187:drug effects* / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology
D003913:Dextroamphetamine