title: Long-term neuropsychological effects and MRI findings in patients with CS2 poisoning.
abstract: OBJECTIVE
  To evaluate the long-term neuropsychological effects and magnetic resonance imaging (MRI) findings among retired patients with a history of exposure to carbon disulfide (CS2).
  
  
  METHODS
  Seventy-four patients with a history of exposure to CS2 were divided into two equal groups according to their level of exposure, and they completed a questionnaire and were evaluated for neuropsychological symptoms using the Korean version of the revised Wechsler Adult Intelligence Scale. Thirty-one MRI images were reviewed retrospectively.
  
  
  RESULTS
  There were no statistically significant differences in total, verbal and performance IQs between high- and low-exposure groups. MRI findings revealed a significantly larger number of cerebral lacunae (five of 12 subjects) in the high-exposure group. Periventricular hyperintensities were mostly located in frontal and occipital areas, and white-matter hyperintensities were mostly in frontal and parietal areas.
  
  
  CONCLUSIONS
  The higher prevalence of lacunae in the high-exposure group as revealed by MRI suggests that further MRI studies are needed into long-term neuropsychological effects induced by CS2.
authors.affiliation: Department of Psychiatry, Eumsung Mental Hospital, Chung-Buk, South Korea. t8780697@yahoo.co.kr
authors.forename: S K
authors.initials: SK
authors.lastname: Cho
authors.forename: R H
authors.initials: RH
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Yim
authors.forename: S W
authors.initials: SW
authors.lastname: Tak
authors.forename: Y K
authors.initials: YK
authors.lastname: Lee
authors.forename: M A
authors.initials: MA
authors.lastname: Son
mesh_terms: D000368:Aged; D001526:Behavioral Symptoms / Q000139:chemically induced* / Q000473:pathology*; D020520:Brain Infarction / Q000139:chemically induced / Q000473:pathology; D002246:Carbon Disulfide / Q000008:administration & dosage / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D002246:Carbon Disulfide