title: Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites.
abstract: BACKGROUND
  There is evidence for membrane abnormalities in schizophrenia. It is unclear whether the observed membrane deficits in peripheral cells parallel central membrane phospholipid metabolism. To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects.
  
  
  METHODS
  Red blood cell membrane fatty acids were measured by capillary gas chromatography and in vivo brain phospholipid metabolite levels were measured using a multi-voxel (31)P Magnetic Resonance Spectroscopy technique on 11 first-episode, neuroleptic-naïve schizophrenic subjects and 11 normal control subjects.
  
  
  RESULTS
  Both the total polyunsaturated fatty acids and the individual 20:4(n-6) contents were significantly correlated with the freely-mobile phosphomonoester [PME(s-tau(c))] levels (r =.5643, p =.0062 and r =.6729, p =.0006, respectively). The 18:2(n-6) polyunsaturated fatty acids content correlated positively with freely-mobile phosphodiester [PDE(s-tau(c))] levels (r =.5573, p =.0071). The above correlations were present in the combined right and left prefrontal region of the brain, while other regions including the basal ganglia, occipital, inferior parietal, superior temporal and centrum semiovale yielded no significant correlations.
  
  
  CONCLUSIONS
  Our preliminary data support the association between the decreased red blood cell membrane phospholipid polyunsaturated fatty acids content and the decreased building blocks [PME(s-tau(c))] and breakdown products [PDE(s-tau(c))] of membrane phospholipids in the prefrontal region of first-episode, neuroleptic-naïve schizophrenic subjects.
authors.affiliation: Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA.
authors.forename: Jeffrey k
authors.initials: Jk
authors.lastname: Yao
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Stanley
authors.forename: Ravinder D
authors.initials: RD
authors.lastname: Reddy
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: Jay W
authors.initials: JW
authors.lastname: Pettegrew
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism*; D002849:Chromatography, Gas; D004910:Erythrocyte Membrane / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism; D012559:Schizophrenia / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D005231:Fatty Acids, Unsaturated; D010743:Phospholipids