title: [Clone of M2 autoantigens from human sources and evaluation of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis].
abstract: OBJECTIVE
  To evaluate the value of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis (PBS).
  
  
  METHODS
  M2 autoantibodies were detected by ELISA combined with western-blot.
  
  
  RESULTS
  Thirty-two cases presented positive M2 autoantibodies, including 20 cases of PBC, 9 liver diseases of unknown etiology, 1 autoimmune hepatitis and 1 drug-induced liver injury.
  
  
  CONCLUSIONS
  M2 autoantibodies show good sensitivity and specificity to diagnosis of PBC. It should be used as a powerful and specific maker for the diagnosis of PBC
authors.affiliation: Clinical Immunology Center of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Jiang
authors.forename: Renqian
authors.initials: R
authors.lastname: Zhong
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Tu
authors.forename: Wenwen
authors.initials: W
authors.lastname: Li
authors.forename: Xiantao
authors.initials: X
authors.lastname: Kong
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D056486:Chemical and Drug Induced Liver Injury; D004797:Enzyme-Linked Immunosorbent Assay; D019693:Hepatitis, Autoimmune; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D001323:Autoantibodies; D001324:Autoantigens