Evaluation of 70/30 D,L-PLa for use as a resorbable interbody fusion cage.
Titanium lumbar interbody spinal fusion devices are reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been debated. Using blinded radiographic, biomechanic, histologic, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) (70/30 D,L-PLa) interbody fusion device packed with autograft or rhBMP-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologic fusion was demonstrated from 3 months to 24 months. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.
Toth
Jeffrey M
JM
Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA.
Wang
Mei
M
Scifert
Jeffrey L
JL
Cornwall
G Bryan
GB
Estes
Bradley T
BT
Seim
Howard B
HB
Turner
A Simon
AS
D020341:Absorbable Implants; D000818:Animals; D001696:Biomechanical Phenomena; D016025:Bone Transplantation / Q000379:methods; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008159:Lumbar Vertebrae; D016348:Osseointegration / Q000502:physiology*; D011091:Polyesters / Q000494:pharmacology*; D011336:Probability; D011474:Prosthesis Design; D011859:Radiography; D012016:Reference Values; D012680:Sensitivity and Specificity; D012756:Sheep; D013123:Spinal Fusion / Q000295:instrumentation* / Q000379:methods; D015996:Survival Rate; D013718:Tensile Strength; D014182:Transplantation, Autologous
D011091:Polyesters; C033616:poly(lactide)