title: Acute reductions in GABAA receptor binding in layer IV of adult primate somatosensory cortex after peripheral nerve injury.
abstract: Following peripheral nerve transection, reorganizational plasticity has been reported to occur in two phases, one immediate and one more protracted. GABA (gamma-aminobutyric acid) has been implicated in the immediate "unmasking" phase of reorganization. We have used quantitative autoradiography to assess potential changes in GABA(A) and GABA(B) receptor binding in primate somatosensory cortex following peripheral nerve injury. Here we report reductions in GABA(A) receptor binding in layer IV of primate somatosensory cortex deprived of its normal activating inputs for 2-5 h by peripheral nerve transection.
authors.affiliation: Department of Psychology, Program in Neural Science, Indiana University, Bloomington, IN 47405, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Wellman
authors.forename: L L
authors.initials: LL
authors.lastname: Arnold
authors.forename: E E
authors.initials: EE
authors.lastname: Garman
authors.forename: P E
authors.initials: PE
authors.lastname: Garraghty
mesh_terms: D000818:Animals; D001345:Autoradiography; D019771:Axotomy; D008475:Median Nerve / Q000293:injuries; D009473:Neuronal Plasticity / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D011963:Receptors, GABA-A / Q000378:metabolism*; D018080:Receptors, GABA-B / Q000378:metabolism; D012453:Saimiri; D013003:Somatosensory Cortex / Q000378:metabolism*; D013997:Time Factors; D014459:Ulnar Nerve / Q000293:injuries
chemical_list: D011963:Receptors, GABA-A; D018080:Receptors, GABA-B