title: Complexes of Co(II) and Zn(II) with ofloxacin. Crystal structure of [Co(oflo)2(MeOH)2].4MeOH.
abstract: Ofloxacin (oflo) is able to interact with Co(II) and Zn(II) salts to form complexes with the general formula [M(oflo)(2)]. 4H(2)O, (M = Co, Zn). Bonding takes place through one of the oxygen atoms of the carboxylate group (acting as a monodentate) and the oxygen atom of the ketonic group. The IR bands of the carboxylic and ketonic group at 1713 and 1622 cm(-1), respectively, shift to 1615 and 1575 cm(-1) in the complexes. After dissolution in methanol, complex [Co(oflo)(2)]. 4H(2)O crystallizes as [Co(oflo)(2)(MeOH)(2)]. 4MeOH, where Co(II) ion is in an octahedral environment of oxygen atoms. This compound crystallizes in the triclinic system, spatial group P-1, with unit cell dimensions a = 9.3670(12), b = 11.4135(17), c = 11.851(2) A y alpha = 71.999(14), beta = 73.698(12), gamma = 83.528(14) degrees. Magnetic properties (effective magnetic moment 5.02 BM) and visible spectrum (bands at 490, 510, and 1152 nm) are characteristic of such an octahedral geometry. (1)H- and (13)C-NMR spectra of the Zn(II) complex indicate only small structural changes in ofloxacin upon coordination to the metallic site.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Salamanca, Spain. bmacias@gugu.usal.es
authors.forename: Benigno
authors.initials: B
authors.lastname: Macias
authors.forename: Maria V
authors.initials: MV
authors.lastname: Villa
authors.forename: Maria
authors.initials: M
authors.lastname: Sastre
authors.forename: Alfonso
authors.initials: A
authors.lastname: Castiñeiras
authors.forename: Joaquin
authors.initials: J
authors.lastname: Borras
mesh_terms: D002626:Chemistry, Pharmaceutical; D003035:Cobalt / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods; D015242:Ofloxacin / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D003035:Cobalt; D015242:Ofloxacin; D015032:Zinc