Cytogenetic analysis of 100 consecutive newly diagnosed cases of acute lymphoblastic leukemia in Rio de Janeiro.
We report the cytogenetic analysis of newly diagnosed Brazilian children with acute lymphocytic leukemia (ALL). We investigated 100 ALL cases from four different institutions in Rio de Janeiro. The frequency of chromosomal abnormalities was 92.3%. The karyotype profile and recurrent abnormalities found in this study do not differ essentially from those described by other groups. Although the Brazilian population is usually the product of different ethnic groups, our results show that the frequency of each recurrent abnormality is similar to that found in populations without our degree of diverse ethnic composition. Hence, our results suggest that childhood ALL in Brazil has the same biological features as that in developed countries, supporting the use of similar treatment protocols. We can therefore expect to reach the same survival rates in the coming years, depending possibly on the efficacy of the support therapy and extent of social assistance.
Silva
Maria Luiza Macedo
ML
Laboratorio de Citogenetica, Centro de Transplante de Medula Ossea (CEMO), Instituto Nacional de Cancer (INCA), Praca Cruz Vermelha 23, 20 230-130 Rio de Janeiro, Brazil. luizamacedo@hotmail.com
Ornellas de Souza
Maria Helena
MH
Ribeiro
Raul C
RC
Land
Marcelo Gerardin Poirot
MG
Boulhosa de Azevedo
Alice Maria
AM
Vasconcelos
Felippe
F
Otero
Luize
L
Vasconcelos
Zilton
Z
Bouzas
Luiz Fernando
LF
Abdelhay
Eliane
E
D000293:Adolescent; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D011003:Ploidies; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology