Real-time monitoring of immune responses.
With the advent of cellular immunotherapy, the ability to monitor immune responses during treatment will be essential to evaluate the effectiveness of the new therapies. While the ultimate determinate of the success of immunotherapy trials will be clinical outcome, methods of monitoring immunity in real-time have become available that will assist in the development of immunotherapy strategies and in the prediction of individual patient prognosis during the course of treatment. The essentials of existing immune assays are described here with examples of how these techniques have been used previously. A perspective on which approaches will likely prove the most useful for monitoring immune responses in real-time during immunotherapy is also presented.
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Section of Transplant Immunology, Department of Blood and Marrow Transplantation, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
D020013:Calcium Signaling / Q000502:physiology; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007111:Immunity, Cellular; D007167:Immunotherapy / Q000379:methods*; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism