Retroviral insertion sites and cancer: fountain of all knowledge?
Retroviral gene tagging is enjoying a renaissance as a gene discovery method since the completion of the draft mouse genome sequence. The potential of this approach to elucidate the genetic basis of cancer is reviewed in the light of a series of recent papers that report the results of high-throughput screens.
Neil
James C
JC
Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden, G61 1QH, Glasgow, UK. j.c.neil@vet.gla.ac.uk
Cameron
Ewan R
ER
D000818:Animals; D016147:Genes, Tumor Suppressor; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D016254:Mutagenesis, Insertional; D009857:Oncogenes; D012190:Retroviridae / Q000235:genetics*; D016662:Virus Integration / Q000235:genetics*