Malaria: new chemotherapeutic peroxide drugs.
Chemical insights into artemisinin's biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.
Borstnik
Kristina
K
Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.
Paik
Ik-Hyeon
IH
Posner
Gary H
GH
D000818:Animals; D018692:Antimanic Agents / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000627:therapeutic use*; D010961:Plasmodium / Q000187:drug effects* / Q000302:isolation & purification; D013329:Structure-Activity Relationship
D018692:Antimanic Agents; D010545:Peroxides