title: Which Kt/V is the most valid for assessment of both long mild and short intensive hemodialyses?
abstract: It is unclear at present which mathematical modeling Kt/V(urea) is valid for assessment of both long mild hemodialysis (HD) and short intensive HD, the single-pool modeling Kt/V (Kt/Vsp) based on the pre- and postdialysis serum urea concentrations, double-pool modeling Kt/V (Kt/Vdp) based on the predialysis concentration and the estimated postdialysis equilibrated concentration, or Kt/V calculated on the basis of dialyzer urea clearance, HD session duration and urea distribution volume (Kt/Vdl). Thus, the respective Kt/V during a short intensive HD was compared with its counterpart Kt/V during a long mild HD, where the same amount of urea is removed during both HD treatments. It was found that the Kt/Vsp and Kt/Vdl during short intensive HD were significantly greater than the respective Kt/V during the long mild HD. On the other hand, there was no significant difference in the Kt/Vdp between the long mild and short intensive HDs. In conclusion, Kt/Vdp may be more valid for assessment of both long mild and short intensive HDs.
authors.affiliation: Department of Outpatient and Home Medicine, Nagoya University, School of Medicine, Nagoya, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Miwa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakai
authors.forename: Masamiki
authors.initials: M
authors.lastname: Miwa
authors.forename: Toru
authors.initials: T
authors.lastname: Shinzato
authors.forename: Kosei
authors.initials: K
authors.lastname: Segawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Maeda
mesh_terms: D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D006435:Renal Dialysis; D014508:Urea / Q000097:blood*
chemical_list: D014508:Urea