title: Successful hematopoietic stem cell transplantation for aplastic anemia following living-related liver transplantation.
abstract: A 1-year-old boy received a living-related liver transplantation (LRLT) from his HLA-haploidentical father to treat acute liver failure following non-A, non-B, non-C hepatitis. He subsequently developed pancytopenia and was diagnosed with aplastic anemia (AA). He was platelet transfusion dependent and developed two episodes of life-threatening intracranial hemorrhage despite immuno-suppressive therapy consisting of cyclosporin A, antithymocyte globulin, and anabolic steroids. He received combined hematopoietic stem cell transplantation (hSCT) with cord blood and bone marrow from an HLA-matched sibling. Conditioning consisted of cyclophosphamide (CY) 200 mg/kg and 7 Gy total lymphoid irradiation (TLI). Marrow engraftment was prompt and there was no significant graft-versus-host disease (GVHD).
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Umeda
authors.forename: S
authors.initials: S
authors.lastname: Adachi
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
authors.forename: T
authors.initials: T
authors.lastname: Nakahata
mesh_terms: D000741:Anemia, Aplastic / Q000209:etiology / Q000628:therapy*; D016026:Bone Marrow Transplantation; D036101:Cord Blood Stem Cell Transplantation; D018572:Disease-Free Survival; D018380:Hematopoietic Stem Cell Transplantation; D006505:Hepatitis / Q000150:complications; D006801:Humans; D007223:Infant; D017114:Liver Failure, Acute / Q000150:complications / Q000628:therapy; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D009679:Nuclear Family; D012074:Remission Induction / Q000379:methods