title: A prospective study of 750 definite spider bites, with expert spider identification.
abstract: BACKGROUND
  Spider bite is a subject of much medical mythology with prevalent fears that spiders cause severe envenoming, with neurotoxic effects or necrotic ulcers. Clinical experience and small studies suggest otherwise, but this has not been confirmed by prospective studies of bites by identified spiders.
  
  
  OBJECTIVE
  To describe the clinical effects of bites by accurately identified spiders, and determine whether early clinical features and circumstances can predict spider type.
  
  
  METHODS
  Prospective follow-up study.
  
  
  METHODS
  Patients were recruited from admissions to two emergency departments (n=48) and referrals from three state poison information centres (n=1426), over 27 months. Overall, there were 750 people with definite spider bites where the spiders were immediately collected and expertly identified.
  
  
  RESULTS
  Significant effects occurred in 44 bites (6%), including 37 (of 56) redback spider bites (Latrodectus hasselti) with significant pain lasting >24 h. Of these, only 6 (11%) received antivenom. One severe neurotoxic envenoming by an Australian funnelweb spider required antivenom. No definite spider bites resulted in necrotic ulcers (0%, 99%CI 0-0.7%). There were no early allergic reactions and secondary infection occurred in seven cases (0.9%, 95%CI 0.4-1.9%). Circumstances and early clinical effects were strongly associated with taxonomic spider identification, with positive predictive values >0.95 for common groups of spiders.
  
  
  CONCLUSIONS
  Australian spider bite caused minor effects in most cases and is unlikely to cause necrotic ulcers, allergic reactions or infection. Redback spider bite (widow spider) caused prolonged pain, and antivenom could have been used more frequently. The circumstances and early clinical features of spider bites may allow early appropriate advice and treatment of spider bite without taxonomic identification.
authors.affiliation: Discipline of Clinical Pharmacology, Level 5, Clinical Sciences Building, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah NSW 2298, Sydney, Australia. gsbite@bigpond.com
authors.forename: G K
authors.initials: GK
authors.lastname: Isbister
authors.forename: M R
authors.initials: MR
authors.lastname: Gray
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001315:Australia; D002648:Child; D002675:Child, Preschool; D005104:Expert Testimony; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D001098:Spider Bites / Q000175:diagnosis*; D013112:Spiders / Q000145:classification*