[Pesticide exposure and Parkinson's syndrome - the epidemiological and experimental evidence].
Retrospective case-control studies among patients with idiopathic Parkinson's syndrome (IPS) show a positive association to the existence of a - mostly premorbid - exposure to pesticides. In acute pesticide intoxications, usually symptoms other than parkinsonism are found. Therefore, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) continues to be the agent best documented both experimentally and clinically to cause a clinical syndrome comparable to IPS. It is debated whether still unknown effects between exogenous pesticide exposure and the xenobiotic enzyme system may lead to IPS in single genetically susceptible individuals. In practice, the present data on the problem of pesticide exposure in IPS are irrelevant for medicolegal considerations.
Vieregge
P
P
Klinik für Neurologie mit klinischer Neurophysiologie, Klinikum Lippe-Lemgo, Germany. peter.vieregge@klinikum-lippe.de
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000009:adverse effects / Q000493:pharmacokinetics; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D001479:Basal Ganglia / Q000187:drug effects / Q000473:pathology; D016022:Case-Control Studies; D004198:Disease Susceptibility; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D020734:Parkinsonian Disorders / Q000139:chemically induced; D010575:Pesticides / Q000009:adverse effects* / Q000493:pharmacokinetics; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors
D010575:Pesticides; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D001189:Aryl Hydrocarbon Hydroxylases