title: Age-related innate immune response in calves to Babesia bovis involves IL-12 induction and IL-10 modulation.
abstract: There is a strong innate immunity in calves to infection with Babesia bovis. Interleukin (IL)-12 and IL-10 have been shown in vitro to be important immunoregulatory cytokines. Here we demonstrate in vivo that the protective innate response in young calves to infection with virulent B. bovis involves the early appearance of IL-12 and interferon-gamma (IFN-gamma) transcripts in the spleen. In contrast, IL-12 and IFN-gamma mRNA expression in the spleens of adult cattle that succumbed to the infection was delayed and depressed and occurred within the context of IL-10 expression. Also in contrast with calves, there was no detectable antibody response before death in adults. A vigorous CD8+ T-cell expansion occurred in the spleens of both calves and adults.
authors.affiliation: Animal Diseases Research Unit, USDA-ARS, Pullman, Washington 99164, USA. wgoff@vetmed.wsu.edu
authors.forename: W L
authors.initials: WL
authors.lastname: Goff
authors.forename: W C
authors.initials: WC
authors.lastname: Johnson
authors.forename: W
authors.initials: W
authors.lastname: Tuo
authors.forename: R A
authors.initials: RA
authors.lastname: Valdez
authors.forename: S M
authors.initials: SM
authors.lastname: Parish
authors.forename: G M
authors.initials: GM
authors.lastname: Barrington
authors.forename: W C
authors.initials: WC
authors.lastname: Davis
mesh_terms: D000367:Age Factors; D000818:Animals; D016793:Babesia bovis / Q000276:immunology* / Q000472:pathogenicity; D001404:Babesiosis / Q000276:immunology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D015870:Gene Expression; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D012333:RNA, Messenger; D016753:Interleukin-10; D018664:Interleukin-12; D007371:Interferon-gamma