title: Brain SPET abnormalities in Alzheimer's disease before and after atrophy correction.
abstract: The aim of this study was to determine which brain structures show the greatest influence of partial volume effects (PVE) in single-photon emission tomography (SPET) studies on Alzheimer's disease (AD). Brain perfusion SPET was performed in 30 patients with probable AD and 62 age-matched healthy volunteers. SPET images were corrected for PVE using grey matter volume segmented from magnetic resonance images. The most prominent changes after PVE correction were observed in the medial temporal structures. The PVE correction revealed a selective decrease in regional cerebral blood flow (rCBF) in the parahippocampal gyrus of AD without rCBF decreases in the hippocampus, which had been observed before correction. This correction seems to be essential in order to achieve accurate measurements of rCBF in SPET, which has limited spatial resolution.
authors.affiliation: Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, 187-8551, Tokyo, Japan. matsudah@ncnpmusashi.gr.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kanetaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Asada
authors.forename: Etsuko
authors.initials: E
authors.lastname: Imabayashi
authors.forename: Seigo
authors.initials: S
authors.lastname: Nakano
authors.forename: Asako
authors.initials: A
authors.lastname: Katoh
authors.forename: Fumiko
authors.initials: F
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D016477:Artifacts; D001284:Atrophy; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002560:Cerebrovascular Circulation; D003545:Cysteine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013382:Subtraction Technique; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine