[Effects of kainic acid that damages the marginal division of rat striatum on hippocampal long-term potentiation].
OBJECTIVE
To investigate the relationship between the marginal division (MrD) of the striatum and other brain regions associated with learning and memory.


METHODS
Long-term potentiation (LTP) was induced by high-frequency stimulation of the perforant path-dentate gyrus, and changes in hippocampal LTP after destruction of the marginal division with kainic acid were observed.


RESULTS
High-frequency stimulation of the perforant path produced significant increases in the peak amplitudes of the population spike (PS) in normal rats and those receiving saline treatment. In rats with damaged MrD, the increase in PS and the excitatory postsynaptic potential were less obvious compared with normal or saline-treated rats, indicating that the LTP of the hippocampus was attenuated by damage of the MrD.


CONCLUSIONS
Damage of the MrD impacts the LTP formation in the hippocampus.
Wang
Jun
J
Institute of Neuroscience, First Military Medical University, Guangzhou 510282, China.
Shu
Si-Yun
SY
Bao
Xin-Min
XM
Li
Sheng-Xiu
SX
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid