Development of a donor-acceptor concept for enzymatic cross-coupling reactions of aldehydes: the first asymmetric cross-benzoin condensation.
Highly enantioenriched mixed benzoins are obtained selectively through a biocatalytical cross-coupling reaction of aromatic aldehydes using ThDP-dependent enzymes.
Dünkelmann
Pascal
P
Institute of Biotechnology 2, Forschungszentrum Jülich, 52425 Jülich, Germany.
Kolter-Jung
Doris
D
Nitsche
Adam
A
Demir
Ayhan S
AS
Siegert
Petra
P
Lingen
Bettina
B
Baumann
Martin
M
Pohl
Martina
M
Müller
Michael
M
D000446:Aldehyde-Lyases / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D001573:Benzoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D002262:Carboxy-Lyases / Q000737:chemistry*; D002384:Catalysis; D007700:Kinetics
D001547:Benzaldehydes; D002262:Carboxy-Lyases; C019778:benzoylformate decarboxylase; D000446:Aldehyde-Lyases; C059416:benzaldehyde lyase; D001573:Benzoin