Neoclerodane and labdane diterpenoids from Plectranthus ornatus.
Three new diterpenoids, a neoclerodane and two labdane derivatives, have been isolated from an acetone extract of Plectranthus ornatus. The structures of these compounds (plectrornatins A-C, 1-3, respectively) were established mainly by spectroscopic means, particularly by 1D and 2D NMR studies and, in the case of the neoclerodane 1, by an X-ray diffraction analysis. Compounds 1 and 3 showed moderate antimicrobial activity against five Candida species and selected Gram negative and Gram positive bacteria strains.
Rijo
Patrícia
P
Faculdade de Farmácia da Universidade de Lisboa, Centro de Estudos de Ciências Farmacêuticas (CECF), Av. das Forças Armadas, P-1649-019 Lisboa, Portugal.
Gaspar-Marques
Cristina
C
Simões
M Fátima
MF
Duarte
Aida
A
Del Carmen Apreda-Rojas
María
M
Cano
Félix H
FH
Rodríguez
Benjamín
B
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045785:Diterpenes, Clerodane; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D031346:Plectranthus / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004224:Diterpenes; D045785:Diterpenes, Clerodane; C433017:labdane; C468586:neoclerodane