[Analysis of CD8(+) and CD8(+)CD28(-) cell subsets in patients with hepatocellular carcinoma].
OBJECTIVE
To study the expression of the costimulatory molecule CD28 on peripheral blood CD8(+)T cells from patients with hepatocellular carcinoma (HCC).


METHODS
The expression of CD28 on CD8(+), CD8(+)CD28(-)- and CD8(+)CD28(+) cell subsets in the peripheral blood obtained from 20 HCC patients and 15 healthy controls were assayed by flow cytometry.


RESULTS
The elevated percentages of CD8(+) cells, decreased percentages of CD8(+)CD28(+) cells and increased percentages of CD8(+)CD28(-)- cells were observed in the peripheral blood of HCC patients as compared with those of the control group (P<0.01). Positive correlation between the percentage of CD8(+)CD28(-)- cells and that of CD8(+) cells were found.


CONCLUSIONS
CD28 expression on CD8(+) T cells was aberrant in the peripheral blood of HCC patients, and the elevation of CD8(+)CD28(-)- cell number results in the increase of CD8(+) cell number.
Qiu
Yu-Rong
YR
Clinical Laboratory, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Yang
Chun-Li
CL
Chen
Lian-Bo
LB
Wang
Qian
Q
D000328:Adult; D018106:CD28 Antigens / Q000032:analysis* / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000276:immunology*; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D018106:CD28 Antigens