title: Acute interstitial nephritis due to nicergoline (Sermion).
abstract: We report a case of acute interstitial nephritis (AIN) due to nicergoline (Sermion). A 50-year-old patient admitted to our hospital for fever and acute renal failure. Before admission, he had been taking nicergoline and bendazac lysine due to retinal vein occlusion at ophthalmologic department. Thereafter, he experienced intermittent fever and skin rash. On admission, clinical symptoms (i.e. arthralgia and fever) and laboratory findings (i.e. eosinophilia and renal failure) suggested AIN, and which was confirmed by pathologic findings on renal biopsy. A lymphocyte transformation test demonstrated a positive result against nicergoline. Treatment was consisted of withdrawal of nicergoline and intravenous methylprednisolone, and his renal function was completely recovered. To our knowledge, this is the first report of nicergoline-associated AIN.
authors.affiliation: Department of Internal Medicine and Clinical Pathology, Kangnam St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jae Hyuck
authors.initials: JH
authors.lastname: Chang
authors.forename: Suk Kyeong
authors.initials: SK
authors.lastname: Lee
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Yeong Jin
authors.initials: YJ
authors.lastname: Choi
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Yang
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Park
authors.forename: Byung Kee
authors.initials: BK
authors.lastname: Bang
mesh_terms: D000208:Acute Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D009530:Nicergoline / Q000009:adverse effects*; D012170:Retinal Vein Occlusion / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D009530:Nicergoline