title: Cellular immunity to viral and fungal antigens after stem cell transplantation.
abstract: Cellular immunity to viral and fungal antigens is often suppressed after stem cell transplantation. Viral infections, in particular infections with cytomegalovirus and Epstein-Barr virus, are often reactivated after allogeneic stem cell transplantation. Pathogenetic factors are immune deficiency and T-cell stimulation in the course of graft-versus-host reactions. Fungal infections are opportunistic infections derived with ubiquitous microorganisms. Immune deficiency, neutropenia, steroid treatment, and antibiotic treatment contribute to the pathogenesis. The study of viral and fungal immunity after allogeneic stem cell transplantation gives insight into the reconstitution of the immune system and tolerance.
authors.affiliation: Department of Hematology and Oncology, Abteilung II, Eberhard-Karls-Universität Tübingen, Germany. hermann.einsele@med.uni-tuebingen.de
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: Holger
authors.initials: H
authors.lastname: Hebart
mesh_terms: D000946:Antigens, Fungal / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007167:Immunotherapy / Q000379:methods; D009894:Opportunistic Infections / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D014184:Transplantation, Homologous / Q000009:adverse effects
chemical_list: D000946:Antigens, Fungal; D000956:Antigens, Viral