title: A retrospective study on adverse reactions to canine vaccines in Japan.
abstract: Adverse reactions to vaccines were examined in 311 canine cases reported to the Ministry of Agriculture, Forestry and Fisheries in Japan during the period of 6 years from April of 1994 to March of 2000, and classified according to their clinical symptoms. There were 27 cases of adverse reactions to rabies virus vaccines. Gastrointestinal symptoms were the most frequently observed (26%), followed by respiratory and/or cardiovascular symptoms (22%) and dermatologic symptoms (11%). There were 284 cases of adverse reactions to non-rabies monovalent vaccines and mixed vaccines. Dermatologic symptoms were the most frequently observed (53%), followed by gastrointestinal symptoms (16%) and respiratory and/or cardiovascular symptoms (14%). Of the total 311 cases, 11 (3.5%) died of adverse reactions to vaccines.
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Ohmori
authors.forename: Kenichi
authors.initials: K
authors.lastname: Masuda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kaburagi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000401:mortality / Q000503:physiopathology; D004285:Dogs; D004342:Drug Hypersensitivity / Q000276:immunology / Q000401:mortality / Q000662:veterinary*; D007564:Japan; D011818:Rabies / Q000276:immunology / Q000517:prevention & control; D011819:Rabies Vaccines / Q000009:adverse effects*; D012189:Retrospective Studies; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D011819:Rabies Vaccines