title: Successful treatment of juvenile myelomonocytic leukemia relapsing after stem cell transplantation using donor lymphocyte infusion.
abstract: Juvenile myelomonocytic leukemia (JMML) is a rare pediatric malignancy. Hematopoietic stem cell transplantation (SCT) is the only curative approach. However, relapse after SCT remains the major cause of treatment failure. Unlike most other pediatric malignancies, JMML may be susceptible to a graft-versus-leukemia (GVL) effect, although, unlike chronic myeloid leukemia, reports of response to donor lymphocyte infusions (DLIs) remain scanty. This is the first report that describes the successful treatment of relapsed JMML with DLI in the absence of further chemotherapy and provides definite proof of a GVL effect in JMML.
authors.affiliation: Great Ormond Street Hospital for Children, London, United Kingdom.
authors.forename: Austen
authors.initials: A
authors.lastname: Worth
authors.forename: Kanchana
authors.initials: K
authors.lastname: Rao
authors.forename: David
authors.initials: D
authors.lastname: Webb
authors.forename: Judith
authors.initials: J
authors.lastname: Chessells
authors.forename: Jane
authors.initials: J
authors.lastname: Passmore
authors.forename: Paul
authors.initials: P
authors.lastname: Veys
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D020544:Graft vs Leukemia Effect; D006801:Humans; D007165:Immunosuppression Therapy; D007223:Infant; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000628:therapy*; D017710:Lymphocyte Transfusion; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D019172:Transplantation Conditioning