title: Pregnancies diagnosed during Depo-Provera use.
abstract: We conducted a review of contraceptive failures among women using Depo-Provera (depot medroxyprogesterone acetate), using reports to the Insurance Division of Planned Parenthood Federation of America, Inc. Cases were included if the Depo-Provera had been given at a Planned Parenthood center and pregnancy had either been diagnosed by, or reported to, a Planned Parenthood center. There were 402 reports of pregnancy from 1994 through 1998. The crude rate of reported pregnancies was 0.42 pregnancies per 1000 women using Depo-Provera each year. Pregnancy was diagnosed after the first trimester in 46% of women. Seventy-seven women (19.1%) received additional Depo-Provera injections while pregnant. Of the women whose date of conception could be estimated, 113 of 258 (45%) became pregnant after the injection. There was no observed increase in ectopic pregnancy rate, and no fetal anomalies were reported. Although pregnancy during Depo-Provera use is rare, it does occur. These pregnancies are frequently unrecognized until beyond first trimester.
authors.affiliation: Boston University School of Medicine, Department of Obstetrics and Gynecology, Boston, MA, USA. lynn.Borgatta@bmc.org
authors.forename: Lynn
authors.initials: L
authors.lastname: Borgatta
authors.forename: Amitasrigowri
authors.initials: A
authors.lastname: Murthy
authors.forename: Cynthia
authors.initials: C
authors.lastname: Chuang
authors.forename: Leah
authors.initials: L
authors.lastname: Beardsley
authors.forename: Michael S
authors.initials: MS
authors.lastname: Burnhill
mesh_terms: D000293:Adolescent; D000328:Adult; D003271:Contraceptive Agents, Female / Q000008:administration & dosage; D005260:Female; D005865:Gestational Age; D006801:Humans; D007267:Injections; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D011247:Pregnancy; D011256:Pregnancy Outcome; D011258:Pregnancy Tests
chemical_list: D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate