title: Sensing nickel. NikRs with two pockets.
abstract: NikR represses expression of a nickel transporter in response to elevated levels of Ni(II). Recent results suggest that repression is elicited by binding of nickel to a high-affinity site, but a low-affinity binding pocket may also play a role.
authors.affiliation: Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Helmann
mesh_terms: D001412:Bacillus subtilis / Q000378:metabolism; D001665:Binding Sites; D004926:Escherichia coli / Q000378:metabolism; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D007700:Kinetics; D009532:Nickel / Q000378:metabolism* / Q000494:pharmacology; D011485:Protein Binding; D012097:Repressor Proteins / Q000378:metabolism*; D014510:Urease / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; C402409:NikR protein, E coli; D012097:Repressor Proteins; D009532:Nickel; D014510:Urease