title: Interaction of colony-stimulating factors and fluorodeoxyglucose f(18) positron emission tomography.
abstract: OBJECTIVE
  To evaluate reports of altered diagnostic images with fluorodeoxyglucose F(18) (FDG) positron emission tomography (PET) after treatment with colony-stimulating factors (CSFs).
  
  
  METHODS
  Literature was identified by a MEDLINE search (1966-December 2001). Key search terms included granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, fluorodeoxyglucose, and emission-computed tomography. English language literature was reviewed.
  
  
  RESULTS
  Reports have suggested altered FDG PET images following CSF treatment. Studies that assessed the effect of CSF administration on FDG PET imaging of the bone and bone marrow were reviewed.
  
  
  CONCLUSIONS
  Administration of CSFs may interfere with accurate FDG PET imaging. Separating FDG PET imaging from CSF therapy by >/=5 days may diminish this interference.
authors.affiliation: School of Pharmacy, Department of Pharmacy Practice and Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Mayer
authors.forename: Edward M
authors.initials: EM
authors.lastname: Bednarczyk
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D016022:Case-Control Studies; D004347:Drug Interactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D016178:Granulocyte-Macrophage Colony-Stimulating Factor