Transition-metal-catalyzed carbon-heteroatom three-component cross-coupling reactions: a new concept for carbothiolation of alkynes.
The deep-seated understanding of flexible ligand behavior of thiolate on transition-metals has paved the way to achieve metal-catalyzed carbothiolations of terminal alkynes. The strategy of the reaction is quite simple: 1) generation of the complex with C-Pt-S fragments formed after the Pd-catalyzed C-S bond-forming cross-coupling reaction, 2) insertion of an alkyne into Pt-S bond to form the complex with a C-Pt-C fragment, and 3) C-C bond-forming reductive elimination.
Kuniyasu
Hitoshi
H
Department of Molecular Chemistry & Frontier Research Center, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. kuni@ap.chem.eng.osaka-u.ac.jp
Kurosawa
Hideo
H