title: Informant-rated cognitive symptoms in normal aging, mild cognitive impairment, and dementia. Initial development of an informant-rated screen (Brief Cognitive Scale) for mild cognitive impairment and dementia.
abstract: An informant-rated cognitive screen may have the potential to reliably help detect early dementia. A valuable scale should have good interitem associations and strong reliability when tested in groups with and without cognitive impairment. Our scale, the Brief Cognitive Scale (BCS), consists of 18 questions designed to assess cognitive function that affects everyday activities. Each question is coded with one of four levels, ranging from no impairment to severe impairment. We administered this screen to 120 subjects: 26 controls, 28 with a diagnosis of mild cognitive impairment (MCI), and 66 with a diagnosis of dementia. In addition, we administered a Folstein Mini-Mental Status Examination (MMSE) to each subject. Our results showed that the BCS scores were lowest in the control group and highest in the dementia group. In our sample, this scale was effective at discriminating between subjects with no cognitive impairment, MCI, and dementia. However, the scale needs further refinement before it can be employed in a clinical setting.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3950 DUMC, Durham, NC 27710, USA. krish001@acpub.duke.edu
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
authors.forename: R M
authors.initials: RM
authors.lastname: Levy
authors.forename: H R
authors.initials: HR
authors.lastname: Wagner
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: K
authors.initials: K
authors.lastname: Gersing
authors.forename: P M
authors.initials: PM
authors.lastname: Doraiswamy
mesh_terms: D000368:Aged; D000375:Aging / Q000523:psychology*; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales