title: Plasma exchange therapy for the treatment of Escherichia coli O-157 associated hemolytic uremic syndrome.
abstract: Plasma exchange (PE) therapy was administered to three patients with Escherichia coli O-157 associated hemolytic uremic syndrome (HUS) in early phase. Following several PE treatments, all cases completely recovered without any apparent complications. The usefulness of PE therapy in removing microbial fragments and inflammatory cytokines was evaluated. The peptidoglycan (PG) level, interleukin-1 receptor antagonist (IL-1Ra) were higher in HUS patients starting PE therapy than in patients who had received several sessions of PE therapy. PE therapy was an effective early phase treatment for Escherichia coli O-157 associated HUS.
authors.affiliation: Department of Urology and Division of Artificial Kidney, Osaka City University Medical School, Osaka City, Japan. nakatani@msic.med.osaka-cu.ac.jp
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuchida
authors.forename: Rikio
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sugimura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takemoto
mesh_terms: D002648:Child; D004731:Endotoxins / Q000097:blood; D004927:Escherichia coli Infections / Q000097:blood / Q000382:microbiology / Q000628:therapy*; D019453:Escherichia coli O157; D005260:Female; D005936:Glucans / Q000097:blood; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000382:microbiology / Q000628:therapy*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000097:blood; D010457:Peptidoglycan / Q000097:blood; D010951:Plasma Exchange; D022603:Shiga Toxins / Q000097:blood; D012795:Sialoglycoproteins / Q000097:blood
chemical_list: D004731:Endotoxins; D005936:Glucans; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D010457:Peptidoglycan; D022603:Shiga Toxins; D012795:Sialoglycoproteins; C044101:endotoxin, Escherichia coli