title: Evidence for the hydrolysis of topical applied liposomal lipids in human stratum corneum.
abstract: Liposomes were incubated with an extract of human plantar stratum corneum. The liposomal lipids were hydrolysed, if composed of soy-bean phosphatidylcholine or phosphatidylglycerol. Rigid lipids were not degraded. The temperature optimum of the hydrolysis was between 30-35degC. CaCl enhanced, while EDTA reduced the rate of hydrolysis, indicating that the hydrolysis is due to a phospholipase A(2).
authors.affiliation: Labsoft Diagnostics AG, Robert-Franz-Ring 21, 06108 Halle, Germany. zellmer@labsoft.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Zellmer
mesh_terms: D000287:Administration, Topical; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D008081:Liposomes / Q000008:administration & dosage* / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000378:metabolism; D010715:Phosphatidylglycerols / Q000008:administration & dosage / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
chemical_list: D008081:Liposomes; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010741:Phospholipases A