Cardiovascular toxicities of immunosuppressive agents.
Cardiovascular disease is one of the major causes of morbidity and mortality following solid organ transplantation. Many of the current immunosuppressive drugs are associated with an increase of one or more risk factors for the development of atherosclerosis. This review compares the mechanism by which individual immunosuppressive agents may impact on these risk factors and the differential contribution of cyclosporine, tacrolimus, mycophenolate, azathioprine, and Rapamycin to these individual risk factors. Attention to the potential cardiovascular toxicities of individual immunosuppressive agents may help design strategies for maintenance of immunosuppression tailored to individual patients.
Miller
Leslie W
LW
Cardiovascular Division, University of Minnesota, Minneapolis, USA. mille278@tc.umn.edu
D000305:Adrenal Cortex Hormones / Q000633:toxicity; D000818:Animals; D002319:Cardiovascular System / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000503:physiopathology; D016572:Cyclosporine / Q000633:toxicity; D003920:Diabetes Mellitus / Q000503:physiopathology; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology; D007166:Immunosuppressive Agents / Q000633:toxicity*; D020123:Sirolimus / Q000633:toxicity; D016559:Tacrolimus / Q000633:toxicity
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus