title: Heterotrimeric G proteins control diverse pathways of transmembrane signaling, a base for drug discovery.
abstract: Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their alpha and betagamma subunits to effectors including adenylylcyclases, ion channels, phospholipases Cbeta, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.
authors.affiliation: Laboratoire de Neuroimmunopharmacologie, INSERM U425, Faculté de Pharmacie, Université Louis Pasteur - Strasbourg 1, BP24, 67401 Illkirch Cedex, France. landry@pharma.u-strasbg.fr
authors.forename: Y
authors.initials: Y
authors.lastname: Landry
authors.forename: J P
authors.initials: JP
authors.lastname: Gies
mesh_terms: D000818:Animals; D015195:Drug Design; D020555:GTP-Binding Protein Regulators; D020962:Heterotrimeric GTP-Binding Proteins / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D021122:Protein Subunits; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D020555:GTP-Binding Protein Regulators; D021122:Protein Subunits; D020962:Heterotrimeric GTP-Binding Proteins