Molecular pharmacophore determination of lipid lowering drugs with the receptor mapping method.
Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.
Ablise
M
M
Xinjiang Medical University, College of Pharmacy, China. mourboul@hotmail.com
Cartier
A
A
Siest
G
G
Visvikis
S
S
Loppinet
V
V
D019295:Computational Biology / Q000379:methods*; D015195:Drug Design; D006034:Glycyrrhetinic Acid / Q000737:chemistry / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D011955:Receptors, Drug / Q000737:chemistry* / Q000187:drug effects; D012984:Software
D000960:Hypolipidemic Agents; D011955:Receptors, Drug; D006034:Glycyrrhetinic Acid