title: Different clones of t(1;12)/t(12;12) involving the ETV6 gene in a case of acute myeloid leukemia.
abstract: We describe here a case of a 77-year-old Japanese man who developed acute myeloid leukemia (AML-M2). Chromosome analysis of the bone marrow blast cells showed 46,XY,del(7q) at onset, and after relapse, two clones, 46,XY,t(1;12) and 46,XY,del(7q),t(12;12), were present. Fluorescence in situ hybridization analysis confirmed that each clone with the 12p abnormality involved the ETV6 gene. These findings suggest that the ETV6 gene rearrangements in this case were apparently independent of contribution to leukemogenesis, because this cytogenetic aberration appeared as a secondary change. To our knowledge, this is the first report of two different clones with ETV6 gene rearrangements in the same patient.
authors.affiliation: First Department of Internal Medicine, Nihon University School of Medicine, 30-1, Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan. takasait@med.nihon-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Saitoh
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Mituru
authors.initials: M
authors.lastname: Inoue
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hatta
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Jin
authors.initials: J
authors.lastname: Takeuchi
authors.forename: Umihiko
authors.initials: U
authors.lastname: Sawada
authors.forename: Takashi
authors.initials: T
authors.lastname: Horie
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D001854:Bone Marrow Cells / Q000473:pathology; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D004268:DNA-Binding Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D000097764:ETS Translocation Variant 6 Protein