New chromosome rearrangement in acute lymphoblastic leukemia.
Cytogenetic findings in leukemia can be used in the diagnosis, prognosis, and in the definition of different subgroups. The most common chromosome abnormalities associated with mature B-cell acute lymphoblastic leukemia (ALL) are t(8;14), t(8;22), t(2;8), and partial duplication of 1q. Various abnormalities involving chromosome 1 have also been reported in ALL. We present a 16-year-old male with mature B-cell ALL whose cytogenetic analysis of bone marrow showed the karyotype of 46,XY,t(8;14)(q24;q32), -15,der(1;15)(p10;q10). The case presented here carries one of the most common abnormalities, t(8;14) (q24;q32), and a new rearrangement, der(1;15)(p10;q10), which has not been described to date in mature B-cell ALL.
Gündüz
Cumhur
C
Department of Medical Biology, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey.
Coğulu
Ozgür
O
Cetingül
Nazan
N
Kantar
Mehmet
M
Cankaya
Tufan
T
Ozkinay
Cihangir
C
Ozkinay
Ferda
F
D000293:Adolescent; D001402:B-Lymphocytes / Q000473:pathology; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics