title: Effects of loud noise exposure on mouse myocardium: a comparison with the rat.
abstract: Loud noise is an environmental stressor of everyday life, which affects different organs and apparati, in particular the cardiovascular system. We have already reported that noise exposure produces significant alterations in the rat myocardium, consisting of mitochondrial damage, which is evident as lysis of the cristae and dilution of the matrix. Since there are high similarities between mouse and human species, the aim of our study was to investigate the effects of acute noise exposure on the mouse heart. We found that noise exposure affects mouse myocardium at similar subcellular sites to those already described in the rat; nonetheless, quantitative analysis of the percentage of altered mitochondria in both species disclosed a clear difference between mouse and rat myocardium, which strongly suggests a different sensitivity to noise stimulus. We hypothesize that the species differences on the extent of myocardial alterations here observed might be due to the zonal pattern of cardiac noradrenergic receptors, which should be the final effectors for noise-induced myocardial changes.
authors.affiliation: Department of Human Morphology and Applied Biology, School of Medicine, University of Pisa. Via Roma, 55. 56126 Pisa Italy. m.gesi@anist.med.unipi.it
authors.forename: Marco
authors.initials: M
authors.lastname: Gesi
authors.forename: Paola
authors.initials: P
authors.lastname: Lenzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Fornai
authors.forename: Michela
authors.initials: M
authors.lastname: Ferrucci
authors.forename: Paola
authors.initials: P
authors.lastname: Soldani
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellegrini
authors.forename: Antonio
authors.initials: A
authors.lastname: Paparelli
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D006325:Heart Atria / Q000648:ultrastructure; D006352:Heart Ventricles / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure*; D009206:Myocardium / Q000166:cytology* / Q000648:ultrastructure; D009622:Noise / Q000009:adverse effects*; D051381:Rats; D013045:Species Specificity