Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D.
Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactant protein D are biologically active in vivo. This review addresses the structural requirements for recognised activities of SP-D in vitro and in vivo, with emphasis on evidence arising from studies with transgenic mice and mouse models of inflammatory lung disease. The potential of truncated recombinant forms of surfactant protein D as novel therapy for infectious and inflammatory disease is discussed.
Clark
Howard
H
Department of Biochemistry, Oxford, United Kingdom. howard.clark@bioch.ox.ac.uk
Reid
Kenneth B M
KB
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000276:immunology*; D008171:Lung Diseases / Q000188:drug therapy; D023421:Models, Animal; D037663:Pulmonary Surfactant-Associated Protein D / Q000737:chemistry* / Q000502:physiology* / Q000627:therapeutic use; D011994:Recombinant Proteins; D013329:Structure-Activity Relationship
D037663:Pulmonary Surfactant-Associated Protein D; D011994:Recombinant Proteins