title: Emerging roles of presynaptic proteins in Ca++-triggered exocytosis.
abstract: The twinning of techniques from biophysics and molecular biology has led to remarkable progress in understanding the molecular mechanisms of synaptic transmission. Here we review the current picture of Ca++-triggered exocytosis, which has emerged from studies of a simple cellular model, the adrenal chromaffin cell. We discuss the molecular players that have been assigned a specific role in a particular step of this process and give a brief outlook on what these insights might tell us about mechanisms of short-term plasticity at classical synapses.
authors.affiliation: Department of Physiology, Saarland University, Homburg, 66421 Germany. jrettig@uniklinik-saarland.de
authors.forename: Jens
authors.initials: J
authors.lastname: Rettig
authors.forename: Erwin
authors.initials: E
authors.lastname: Neher
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D019439:Chromaffin Cells / Q000378:metabolism*; D005089:Exocytosis; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity; D018377:Neurotransmitter Agents / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism; D050765:Qa-SNARE Proteins; D050600:SNARE Proteins; D022142:Secretory Vesicles / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism; D033921:Vesicular Transport Proteins
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D050765:Qa-SNARE Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D002118:Calcium