[Bilateral pheochromocytomas and asynchronous bilateral renal cell carcinomas associated with von Hippel-Lindau disease: a case report].
A 38-year-old man who had been followed with diagnosis of dilated cardiomyopathy and retinal angioma was referred to our hospital because of incidentally detected bilateral adrenal masses. Although he was normotensive, levels of catecholamine in urine were elevated and I131-MIBG scintigraphy showed accumulation in bilateral adrenal glands. Screening of central nervous system by MRI revealed cerebellar hemangioblastoma. Right adrenalectomy and left partial adrenalectomy were performed, both of which tumors pathologically diagnosed as pheochromocytoma, followed by resection of the cerebellar hemangioblastoma. Five months later, abdominal CT revealed a left renal tumor and underwent left partial nephrectomy, being diagnosed as renal cell carcinoma. A right renal tumor was detected on follow up CT at 1 year after the partial nephrectomy. Since cardiac function was deteriorated, we have followed with careful observation. This is the second documented case of bilateral renal cell carcinomas and bilateral pheochromocytomas with VHL in Japan.
Suzuki
Kazuya
K
Department of Urology, Niigata University School of Medicine.
Kosegawa
Etsuko
E
Hoshii
Tatsuhiko
T
Miyajima
Norio
N
Takahashi
Eisuke
E
Watanabe
Ryusuke
R
Obara
Kenji
K
Tomita
Yoshihiko
Y
Takahashi
Kohta
K
Yoshida
Minoru
M
Yao
Masahiro
M
D000310:Adrenal Gland Neoplasms / Q000209:etiology*; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000209:etiology*; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D010673:Pheochromocytoma / Q000209:etiology*; D006623:von Hippel-Lindau Disease / Q000150:complications*