title: Increases in the release and metabolism of serotonin in nucleus parafascicularis thalami following systemically administered morphine in the rat.
abstract: The effects of systemically administered morphine on the release and metabolism of serotonin (5-HT) in nucleus parafascicularis thalami were evaluated using in vivo microdialysis. The extracellular concentration of 5-HT and its major metabolite 5-hydroxyindoleacetic acid were increased in a dose-dependent manner following the subcutaneous administration of 2.5 and 5 mg/kg morphine sulfate. These results are consistent with findings that the antinociceptive action of morphine is partially mediated through the action of 5-HT within nucleus parafascicularis.
authors.affiliation: Department of Psychology, 71 W Warren Avenue, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Munn
authors.forename: George S
authors.initials: GS
authors.lastname: Borszcz
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry; D005110:Extracellular Space / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D020646:Intralaminar Thalamic Nuclei / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D012701:Serotonin / Q000378:metabolism*; D014828:Vocalization, Animal / Q000502:physiology
chemical_list: D000701:Analgesics, Opioid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009020:Morphine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin