title: Nicotine decreases bradykinesia-rigidity in haloperidol-treated patients with schizophrenia.
abstract: We applied nicotine 21 mg and matching placebo transdermal patches to thirty haloperidol-treated patients with schizophrenia who smoked. Clinical assessments of bradykinesia-rigidity were lower during nicotine patch administration than during placebo patch administration.
authors.affiliation: National Cheng Kung University, Taiwan, China.
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Leann
authors.initials: L
authors.lastname: Nelson
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Kamaraju
authors.forename: William
authors.initials: W
authors.lastname: Wilson
authors.forename: Joseph P
authors.initials: JP
authors.lastname: McEvoy
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D018476:Hypokinesia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012907:Smoking / Q000378:metabolism
chemical_list: D018726:Anti-Dyskinesia Agents; D009538:Nicotine; D006220:Haloperidol