Imaging databases and neuroscience.
Brain atlases are equivalent to neuroimage databases provided an appropriate coordinate system to enable multisubject comparisons, along with comprehensive descriptions of the data, are included. Warping tools, visualization, and statistical analyses that accommodate the various neuroimaging modalities can be used to integrate diverse data and form comprehensive maps describing a particular subpopulation's brain structure and function. By linking task performance and genetic information to brain morphology, complex interrelations between genotype, phenotype, and behavior can be established. Several examples of these multimodal, multisubject atlases, including those that are dynamic, are presented.
Toga
Arthur W
AW
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA. toga@loni.ucla.edu
D000818:Animals; D001271:Atlases as Topic; D001519:Behavior; D001931:Brain Mapping / Q000379:methods*; D016208:Databases, Factual / Q000941:ethics / Q000331:legislation & jurisprudence / Q000639:trends*; D003952:Diagnostic Imaging / Q000941:ethics / Q000639:trends; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D009488:Neurosciences / Q000193:education / Q000639:trends*; D010641:Phenotype