From information management to protein annotation: preparing protein structures for drug discovery.
In contrast to academic pursuits of structural genomics, Structural GenomiX (SGX) solves protein structures at high throughput for the main purpose of enhancing drug-discovery projects, either internally or in partnership with pharmaceutical/biotechnology companies. This involves a radical redesign of the pipeline of methods that turn a gene sequence into a three-dimensional protein structure. The various processes all report electronically to a Laboratory Information Management System (LIMS) to make sure all the parameters of the experiment are recorded in an accessible and 'mineable' form, helping guarantee reproducibility of results. Quality control at several key points keeps the process from branching out on a wrong hypothesis. Protein annotation, in a broad sense, takes care of the interpretation of a protein crystal structure or the crystal structure of one or several protein-ligand complexes. This interpretation both gathers all necessary biological information (protein function, mechanism, specific features within a protein family etc.) and hands over this information in a form accessible to medicinal chemistry teams designing specific small-molecule agonists or antagonists.
Peat
Tom
T
Structural GenomiX Inc, USA.
de La Fortelle
Eric
E
Culpepper
Janice
J
Newman
Janet
J
D003460:Crystallization; D030562:Databases, Protein; D015195:Drug Design; D016247:Information Storage and Retrieval; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics
D011506:Proteins