A stereodivergent approach to substituted 4-hydroxypiperidines.
A stereodivergent route toward both diastereomeric forms of functionalized 4-hydroxypiperidines has been successfully developed. This route involves biocatalytic generation of the enantiopure starting materials followed by functionalization via N-acyliminium ion-mediated CC-bond formation.
Vink
Mandy K S
MK
Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, The Netherlands.
Schortinghuis
Christien A
CA
Luten
Jordy
J
Van Maarseveen
Jan H
JH
Schoemaker
Hans E
HE
Hiemstra
Henk
H
Rutjes
Floris P J T
FP