Blood flow control during exercise: role for the venular endothelium?
During an increasing metabolic demand, as in exercise, the close venular-arteriolar pairing allows for diffusion of vasoactive substances from the venular blood to the arterioles. Adenosine triphosphate release from red blood cells may stimulate the venular endothelium to release vasoactive metabolites of arachidonic acid. The venous circulation is in an optimal position to provide a feedback regulation of arteriolar diameter.
Hester
Robert L
RL
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA. rhester@physiology.umsmed.edu
Choi
Jaehwa
J
D000255:Adenosine Triphosphate / Q000378:metabolism; D016718:Arachidonic Acid / Q000378:metabolism; D001160:Arterioles / Q000502:physiology; D001775:Blood Circulation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology; D014664:Vasodilation / Q000502:physiology; D014699:Venules / Q000502:physiology
D016718:Arachidonic Acid; D000255:Adenosine Triphosphate