Oestrogenicity and effect on hepatic metabolism of the aqueous extract of the leaf mixture of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis.
The aqueous extract of the leaf mixtures of Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis given by oral route to immature female rats, at doses of 13, 49 and 94 mg/kg per day for 15 days induced a significant increase in ovarian and uteri weight as well as serum and ovarian oestradiol. Moreover, a significant decrease in liver of aminopyrine N-demethylase activity was noticed in treated animals.
Telefo
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Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 67, Dschang, Cameroon. bphelix@yahoo.co.uk
Moundipa
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Tchouanguep
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FM
D027901:Acanthaceae; D000284:Administration, Oral; D000504:Aloe; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031584:Hibiscus; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D010053:Ovary / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects
D005300:Fertility Agents, Female; D010936:Plant Extracts; D004958:Estradiol; D000633:Aminopyrine N-Demethylase