Simple synthesis of alpha-hydroxyamino carbonyl compounds: new scope of the nitroso aldol reaction.
[reaction: see text] The reaction of nitroso compounds with enolates, "the nitroso aldol reaction", occurs in high yield to generate alpha-hydroxyamino carbonyl compounds. Yields range from 42% to 98% with N-selectivity >99:1 from commercially available aromatic or aliphatic nitroso compounds and a variety of alkali metal or tin enolates.
Momiyama
Norie
N
Graduate School of Engineering, Nagoya University, SORST, Japan Science and Technology Corporation (JST), Chikusa, Nagoya 464-8603, Japan.
Yamamoto
Hisashi
H