DNA Interaction and photonicking properties of DNA-targeted acridine (2,2'-Bipyridine)platinum(II) complexes.
Synthesis of two (2,2'-bipyridine)platinum(II) complexes tethered to one or two acridine chromophores is reported. These acridine complexes efficiently unwind and photocleave supercoiled plasmid DNA under physiological conditions of temperature and pH.
Gude
Lourdes
L
Departamento de Qui;mica Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.
Fernández
María-José
MJ
Grant
Kathryn B
KB
Lorente
Antonio
A
D000166:Acridines / Q000494:pharmacology*; D004278:DNA, Superhelical / Q000187:drug effects*; D024202:Electrophoretic Mobility Shift Assay; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009690:Nucleic Acid Conformation; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010777:Photochemistry; D010957:Plasmids / Q000187:drug effects / Q000235:genetics; D013055:Spectrophotometry, Infrared; D013696:Temperature
D000166:Acridines; D004278:DNA, Superhelical; D009944:Organoplatinum Compounds; C471986:acridine (2,2'-Bipyridine)platinum(II)