Effects of peripheral administration of 5-hydroxytryptamine (5-HT ) on 2-deoxy-D-glucose-induced hyperphagia in rats.
Effects of peripheral administration of 5-HT (5-hydroxytryptamine, serotonin) on hyperphagia induced by 2-deoxy-D-glucose(2-DG) were studied in rats. It was found that 5-HT i.p. reduced 2-DG-elicited feeding in rats dose-dependently. The 5-HT-induced hypophagia was antagonized by the 5-HT2A receptor antagonist, ketanserin. It is known that 2-DG induces glucoprivation, resulting in hyperphagia and hyperglycemia. However, 5-HT did not affect hyperglycemia induced by 2-DG. These results suggest that peripheral injection of 5-HT reduces 2-DG-induced hyperphagia mediated by the peripheral 5-HT2A receptor and that its effects are not due to enhancement of hyperglycemia.
Sugimoto
Yumi
Y
Department of Pharmacology, Kobe Pharmaceutical University, Japan. yumisugi@kobepharma-u.ac.jp
Yoshikawa
Tomoko
T
Yamada
Jun
J
D000818:Animals; D003847:Deoxyglucose / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D006963:Hyperphagia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000008:administration & dosage*; D012702:Serotonin Antagonists / Q000494:pharmacology
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D003847:Deoxyglucose