title: Short tandem repeat polymorphism of the D2S1242 locus in a Japanese population.
abstract: Allele frequencies and sequence characteristics of the D2S1242 short tandem repeat (STR) locus were studied in a Japanese population sample. A total of 10 D2S1242 alleles and 34 genotypes were identified in 273 unrelated Japanese individuals. The five most common alleles detected had frequencies of over 10%. No deviations from Hardy-Weinberg equilibrium were found when the expected allele values were compared with the observed values. Sequence analysis of each allele showed a tetranucleotide polymorphism. Alleles 9 to 14 had different sequence structures than alleles 15 to 19. Allele 18 had a different sequence in the Japanese sample compared to an Austrian sample. The power of discrimination was 0.95. The present results demonstrate that the D2S1242 STR locus is a useful genetic marker in the Japanese population.
authors.affiliation: Department of Legal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Jian
authors.initials: J
authors.lastname: Tie
authors.forename: Yuka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Shojiro
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Shigemi
authors.initials: S
authors.lastname: Oshida
mesh_terms: D000483:Alleles; D001483:Base Sequence; D016009:Chi-Square Distribution; D005819:Genetic Markers; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences
chemical_list: D005819:Genetic Markers