A reeler mutant mouse with a new, spontaneous mutation in the reelin gene.
In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb intragenic deletion comprising exons 13-20.
Andersen
Tom E
TE
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Finsen
Bente
B
Goffinet
Andre M
AM
Issinger
Olaf-Georg
OG
Boldyreff
Brigitte
B
D000818:Animals; D001483:Base Sequence / Q000235:genetics; D015816:Cell Adhesion Molecules, Neuronal / Q000172:deficiency / Q000235:genetics*; D002531:Cerebellum / Q000002:abnormalities / Q000503:physiopathology; D004247:DNA / Q000032:analysis / Q000235:genetics; D015536:Down-Regulation / Q000235:genetics; D005091:Exons / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000172:deficiency / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009419:Nerve Tissue Proteins; D010641:Phenotype; D012333:RNA, Messenger / Q000378:metabolism; D000091042:Reelin Protein; D012697:Serine Endopeptidases
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D000091042:Reelin Protein; D004247:DNA; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases