title: Olfactory function in Parkinsonian syndromes.
abstract: The study aimed to compare olfactory function in idiopathic Parkinson's disease (IPD) and nonidiopathic Parkinson's syndrome (PS). At their first visit 50 PS patients (age 38-80 years) received testing for odor threshold, olfactory discrimination and identification. All patients underwent extensive neurological diagnostics including PET scans. Patients were followed up for 6-12 months. Most of IPD patients were functionally anosmic (n=19), the remaining IPD patients had severe/moderate hyposmia (n=18). PS patients diagnosed with multiple system atrophy had less severe olfactory deficits (7 hyposmia, 1 normosmia). With the exception of 1 hyposmic patient, other PS patients had no olfactory deficits (progressive supranuclear palsy, corticobasal degeneration, psychogenic PS, essential tremor). This study added to previous findings: (1) there was no major difference betwesen olfactory function in IPD subtypes; (2) all olfactory tests differentiated IPD from nonIPD. These data suggest that olfactory probes improve the diagnostic armamentarium in IPD.
authors.affiliation: Department of Neurology, University of Dresden Medical School, 01307 Dresden, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Müngersdorf
authors.forename: H
authors.initials: H
authors.lastname: Reichmann
authors.forename: G
authors.initials: G
authors.lastname: Strehle
authors.forename: T
authors.initials: T
authors.lastname: Hummel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000175:diagnosis / Q000523:psychology; D009483:Neuropsychological Tests; D000857:Olfaction Disorders / Q000175:diagnosis / Q000209:etiology; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D012684:Sensory Thresholds / Q000502:physiology; D012903:Smell / Q000502:physiology*
chemical_list: D000978:Antiparkinson Agents