[Development of artificial bone made from nacre and polylactic acid and property assessment].
OBJECTIVE
To explore a new bone substitute for bone grafting and evaluate its properties.


METHODS
Pressurized molding of nacre, polylactic acid and NaCl that were proportionally mixed was performed to obtain the bone grafting material, and its properties as porosity, pore size and mechanical strength were compared with those of the material prepared by solvent casting.


RESULTS
Compared with that of the material made by solvent casting, the mechanical strength of the new artificial bone material was 10-fold stronger with an average porosity rate of 47.65%, pore size of 218.83 micrometer compressive strength of 16.10 MPa and flexural strength of 60.18 MPa.


CONCLUSIONS
The new technique adopted in this study can effectively enhance the biomechanics of the artificial bone material, which can be suitable for repairing bone defect.
Liu
Jin-Biao
JB
Department of Spinal and Orthopaedics Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Chen
Jian-Ting
JT
D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D018786:Bone Substitutes / Q000737:chemistry* / Q000592:standards; D004339:Drug Compounding / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry
D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; D012965:Sodium Chloride; C033616:poly(lactide)