Amylin, food intake, and obesity.
Amylin, also known as islet amyloid polypeptide, identified in 1987, is a naturally occurring hormone, released by the beta cells of the pancreas and consists of 37 amino acids. Amylin seems to decrease food intake through both central and peripheral mechanisms and indirectly by slowing gastric emptying. The mean basal amylin concentration is higher in obese than in lean human subjects. The amylin response to oral glucose is also greater in obese subjects, whether or not they have impaired glucose tolerance. The elevated amylin levels in obesity may lead to down-regulation of amylin receptors and lessen the impact of postprandial amylin secretion on satiety and gastric emptying. Amylin administration may overcome resistance at target tissues, delay gastric emptying, and have potential for inducing weight loss in obese individuals.
Reda
Tarek K
TK
New York Obesity Research Center, Department of Medicine, St.-Luke's-Roosevelt Hospital Center, Columbia University-College of Physicians and Surgeons, New York, USA. tarekreda@link.net
Geliebter
Allan
A
Pi-Sunyer
F Xavier
FX
D000682:Amyloid / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008297:Male; D009765:Obesity / Q000378:metabolism*; D012528:Satiety Response / Q000502:physiology
D000682:Amyloid; D058228:Islet Amyloid Polypeptide