title: Attachment of neutrals during tandem mass spectrometry of sulfonic acid dyes and intermediates in an ion trap.
abstract: Several positional isomers of 2-(2-quinolinyl)-1H-indene-1,3(2H)-dione mono- and disulfonic acids prepared as reference materials for development of analytical methods involved in FDA certification of D&C Yellow No. 10 (Quinoline Yellow) were found consistently to show [MH + 14](+) ions when their electrospray- or atmospheric pressure chemical ionization-prepared MH(+) ions were subjected to collisional activation. The source of these ions was found to be the methanol used as solvent in these procedures which combined with their [MH - H(2)O](+) ions under chemical ionization conditions. The reaction was found to be sensitive to their isomeric and chemical structures and other examples of this process are reviewed.
authors.affiliation: Office of Cosmetics and Colors, US Food and Drug Administration, Washington, DC 20204, USA. aweisz@cfsan.fda.gov
authors.forename: Adrian
authors.initials: A
authors.lastname: Weisz
authors.forename: Denis
authors.initials: D
authors.lastname: Andrzejewski
authors.forename: Henry M
authors.initials: HM
authors.lastname: Fales
authors.forename: Asher
authors.initials: A
authors.lastname: Mandelbaum
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents / Q000032:analysis*; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D011804:Quinolines; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013451:Sulfonic Acids / Q000032:analysis*
chemical_list: D004396:Coloring Agents; D007202:Indicators and Reagents; D011804:Quinolines; D012997:Solvents; D013451:Sulfonic Acids; C019303:quinoline yellow