Different distribution of Dukes' stage between proximal and distal colorectal cancer.
OBJECTIVE
As different features of colorectal cancer between proximal and distal sites are influenced mainly by proximal shift and diagnostic improvement, a comparison of proximal and distal cancer sites may provide clues as to appropriate strategy for colorectal cancer treatment.


METHODS
The clinicopathological data on 676 patients with colorectal cancer was compared regarding the proximal and distal sites.


RESULTS
In cases of cancer without metastasis (Dukes' A or B), the incidence of Dukes' A was higher in the distal than in the proximal site (11.2% vs. 24.3%), while the incidence of Dukes' B was lower in the distal than the proximal site. In cases of cancer with metastasis (Dukes' C or D), the incidence of Dukes' C and Dukes' D tumors was similar between proximal and distal sites.


CONCLUSIONS
A large number of Dukes' A cancer in distal site may be slow growing with low metastatic potential.
Ikeda
Yoichi
Y
Department of Surgery II, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Akagi
Kazunari
K
Kinoshita
Junko
J
Abe
Toru
T
Miyazaki
Mituhiro
M
Mori
Masaki
M
Sugimachi
Keizo
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016019:Survival Analysis