[Preventing effect of angiotensin II receptor blocker on neointimal hyperplasia after vascular injury].
Percutaneous transluminal coronary angioplasty (PTCA) and stent implantation are useful techniques for treating patients with coronary atherosclerosis. However, the long-term efficacy of these treatment is limited by vascular restenosis, which occurs after these procedures. Although ACE inhibitor cilazapril prevented the neointimal hyperplasia of rat carotid artery after balloon injury, it did not lead to prevention of restenosis after PTCA in human studies (MERCATOR and MARCATOR). Angiotensin II receptor blocker, candesartan, inhibited the neointimal formation after balloon injury in both rat and dog. Val-PREST trial showed that valsartan reduced the in-stent restenosis rate after stent implantation. The inhibition of renin-angiotensin system by angiotensin II receptor blocker may help to prevent restenosis after angioplasty.
Miyata
Masaaki
M
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University.
Eto
Hideyuki
H
Biro
Sadatoshi
S
Tei
Chuwa
C
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D023903:Coronary Restenosis / Q000517:prevention & control*; D004285:Dogs; D006801:Humans; D006965:Hyperplasia; D051381:Rats; D015607:Stents / Q000009:adverse effects; D017539:Tunica Intima / Q000473:pathology*
D057911:Angiotensin Receptor Antagonists