The p47phox PX domain: two heads are better than one!
The recent X-ray structure of the PX domain of p47phox, a critical subunit of the NADPH oxidase, unexpectedly revealed the presence of two distinct lipid binding pockets within this single modular domain. This unusual feature allows the p47phox PX domain to integrate signal transduction events emerging from two different lipid signaling pathways.
Yaffe
Michael B
MB
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
D008958:Models, Molecular; D019255:NADPH Oxidases; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D014961:X-Ray Diffraction
D010750:Phosphoproteins; D019255:NADPH Oxidases; C060505:neutrophil cytosolic factor 1