Receptor pharmacogenetics: relevance to CNS syndromes.
Pharmacogenetic research dedicated to the investigation of inherited factors that influence drug response has produced exciting results over the past decade. Adding to the knowledge that genetic variation in metabolic enzymes may cause drug-related adverse reactions, recent studies indicate that variation in neurotransmitter receptors can also be the cause of treatment failure. In addition, recent studies have attempted to use genetic information for the prediction of treatment outcome. The aim of this review is to summarize the most significant findings in pharmacogenetic research in relation to CNS drugs and to outline how these studies could lead to the individualization of drug treatment.
Shaikh
Sanober
S
Clinical Neuropharmacology, Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Kerwin
Robert W
RW
D002493:Central Nervous System Diseases / Q000235:genetics*; D002799:Cholinergic Fibers / Q000502:physiology; D015894:Genome, Human; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D011954:Receptors, Dopamine / Q000235:genetics; D017981:Receptors, Neurotransmitter / Q000235:genetics
D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter