title: [Micronuclei induced by chronic inhalation of SO2 in mouse bone marrow cells].
abstract: In the chronic inhalation experiment of sulfur dioxide(SO2), micronuclei(MN) frequencies in the polychromatophilic erythroblasts(PCE) of mouse bone marrow and the frequencies of cells with MN were significantly increased in dose-dependent manner. There was a significant difference between the male and the female animals. The results also showed that SO2 inhibited urethone-induced MN formation. These results furtherly confirm that SO2 inhalation was a clastogenic and genotoxic agent to mammalian cells, and the combined effects of SO2 and other mutagens are complex.
authors.affiliation: Institute of Environmental and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006.
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Meng
authors.forename: Aidong
authors.initials: A
authors.lastname: Ruan
authors.forename: Nan
authors.initials: N
authors.lastname: Sang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Jianbiao
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D012737:Sex Factors; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D013458:Sulfur Dioxide