title: Delayed and prolonged cholestatic hepatitis with ductopenia after long-term ciprofloxacin therapy for Crohn's disease.
abstract: Ciprofloxacin, a fluorinated quinolone, is a powerful antibiotic widely used for its broad spectrum of activity in ambulatory and long-term care setting. Until now, ciprofloxacin administration has been associated with a few cases of acute, sometimes cholestatic jaundice or fulminant hepatic failure believed mainly related to idiosyncratic hypersensitivity. We report a case of delayed and prolonged cholestatic hepatitis with ductopenia occurring after 6 months of treatment in a patient with Crohn's disease. This observation suggests the potential for the drug to induce long-term likely dose-related severe hepatotoxicity.
authors.affiliation: Department of Gastroenterology and Pathology, Saint Luc University Hospital, Université Catholique de Louvain, 10 Avenue Hippocrate, 1200 Brussels, Belgium.
authors.forename: Laurent
authors.initials: L
authors.lastname: Bataille
authors.forename: Jacques
authors.initials: J
authors.lastname: Rahier
authors.forename: André
authors.initials: A
authors.lastname: Geubel
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects*; D001652:Bile Ducts / Q000473:pathology*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000009:adverse effects*; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin