Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer.
BACKGROUND
Multiple clinical, biologic, and pathologic factors are known to correlate with outcome in patients with invasive breast cancer. The utility of lymphovascular invasion as an additional useful prognostic indicator has been heretofore ill defined. The purpose of the current study was to determine whether the presence or absence of peritumoral lymphovascular invasion (LVI) contribute further significant information in assessing survival.


METHODS
Using a prospective database of 1,258 patients with invasive breast cancer followed up for as long as 12 years, eight factors were evaluated for their impact on patient survival: lymph node status, LVI, age at diagnosis, tumor size, tumor palpability, estrogen and progesterone receptor status, and nuclear grade.


RESULTS
Multivariate analysis revealed that both lymph node status and the presence or absence of LVI were highly significant independent predictors of outcome.


CONCLUSIONS
Knowledge of both lymph node status and the presence or absence of LVI can be used to predict which subset of patients will do extremely well (node negative + LVI absent) or extremely poorly (node positive + LVI present). The combination of the two factors is most meaningful in patients with 1 to 3 positive nodes.
Woo
Carol S
CS
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Silberman
Howard
H
Nakamura
Shelley K
SK
Ye
Wei
W
Sposto
Richard
R
Colburn
William
W
Waisman
James R
JR
Silverstein
Melvin J
MJ
D000328:Adult; D001365:Axilla; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D013997:Time Factors