Structure, function and modulation of chemokine receptors: members of the g-protein-coupled receptor superfamily.
Chemokine receptors are membrane proteins that play an important role in inflammation and the cellular entry of human immunodeficiency virus type I (HIV-1). Understanding the structure-function relationship of chemokine receptor-ligand interactions and developing novel strategies to control these interactions have important implications for therapeutic intervention of human diseases such as HIV-1 infection. This article reviews the work carried out in our laboratory in molecular modeling and site-directed mutagenesis of chemokine receptor-ligand interactions and chemical synthesis of chemokine-derived peptide agonists and antagonists. These studies demonstrate a paradigm for exploring and controlling membrane protein-protein interactions.
Huang
Ziwei
Z
Department of Biochemistry, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, 61801, USA. z-huang@life.uiuc.edu
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D019204:GTP-Binding Proteins; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D019707:Receptors, Chemokine / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D008024:Ligands; D019707:Receptors, Chemokine; D019204:GTP-Binding Proteins