title: Antirecoverin antibody in the aqueous humor of a patient with cancer-associated retinopathy.
abstract: OBJECTIVE
  To describe a patient with cancer-associated retinopathy (CAR) in whom antirecoverin antibody was found in the aqueous humor.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 65-year-old man underwent resection of adenocarcinoma of the lung in June 1991 and noted deterioration of vision 10 months later. Goldmann perimetry revealed a ring-like scotoma in each eye, and the electroretinogram was nonrecordable. Aqueous humor and peripheral venous blood were collected for Western blot analysis from this patient and three other patients during surgery for age-related cataract.
  
  
  RESULTS
  We found antirecoverin antibody within the aqueous humor and serum in the patient with CAR. In contrast, such imunoreactivities were not observed in specimens from the control patients.
  
  
  CONCLUSIONS
  These observations strongly suggest that antirecoverin antibody penetrates into the aqueous humor and vitreous cavity beyond the blood-retina barrier in CAR.
authors.affiliation: Department of Ophthalmology, Hirosaki University School of Medicine, Japan. ooguro@cc.hirosaki-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohguro
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Maruyama
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakazawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Oohira
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D000906:Antibodies / Q000032:analysis* / Q000097:blood; D001082:Aqueous Humor / Q000276:immunology*; D002135:Calcium-Binding Proteins / Q000276:immunology*; D005136:Eye Proteins; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000276:immunology; D051603:Recoverin; D012016:Reference Values; D012162:Retinal Degeneration / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D012607:Scotoma / Q000209:etiology* / Q000503:physiopathology; D014794:Visual Fields
chemical_list: D000906:Antibodies; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin