ATP and control of intracellular growth of mycobacteria by T cells.
Extracellular ATP at millimolar concentrations inhibits growth of mycobacteria in human macrophages. Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes.
Canaday
David H
DH
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44109, USA. dxc44@cwru.edu
Beigi
Reza
R
Silver
Richard F
RF
Harding
Clifford V
CV
Boom
W Henry
WH
Dubyak
George R
GR
D000255:Adenosine Triphosphate / Q000502:physiology*; D015550:Cell Degranulation; D002460:Cell Line; D006801:Humans; D009000:Monocytes / Q000502:physiology; D009163:Mycobacterium bovis / Q000254:growth & development*; D013601:T-Lymphocytes / Q000502:physiology*
D000255:Adenosine Triphosphate