title: Facilely accessible multidrug resistance modulator derived from sucrose.
abstract: Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3',4'-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
authors.forename: Nobutoshi
authors.initials: N
authors.lastname: Murakami
authors.forename: Satoru
authors.initials: S
authors.lastname: Tamura
authors.forename: Etsuko
authors.initials: E
authors.lastname: Iwata
authors.forename: Shunji
authors.initials: S
authors.lastname: Aoki
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Akiyama
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006801:Humans; D013329:Structure-Activity Relationship; D013395:Sucrose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014700:Verapamil / Q000494:pharmacology
chemical_list: D013395:Sucrose; D014700:Verapamil