Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora.
Seven stilbenes, a new cis-epsilon-viniferin and the six known stilbenes, trans-resveratrol, trans-resveratrol-4'-O-beta-D-glucopyranoside, trans-epsilon-viniferin, gnetin H, and suffruticosol A and B, were isolated and identified from seeds of Paeonia lactiflora. The antioxidative activity of these stilbene derivatives was evaluated against the 2-deoxyribose degradation and rat liver microsomal lipid peroxidation induced by the hydroxyl radical generated via a Fenton-type reaction. Among these stilbenes, trans-epsilon-viniferin and gnetin H significantly inhibited 2-deoxyribose degradation and lipid peroxidation in rat liver microsomes. In addition, cis-epsilon-viniferin, and suffruticosol A and B also exhibited moderate antioxidative activity. These results suggest that resveratrol dimers and trimers, together with resveratrol from seeds of Paeonia lactiflora may be useful as potential sources of natural antioxidants.
Kim
Hyo Jin
HJ
Department of Food Science and Nutrition, Catholic University of Daegu, Hayang, Gyeongbuk, Korea
Chang
Eun Ju
EJ
Cho
Sung Hee
SH
Chung
Shin Kyo
SK
Park
Heui Dong
HD
Choi
Sang Won
SW
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D003855:Deoxyribose / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D029596:Paeonia / Q000737:chemistry*; D051381:Rats; D000077185:Resveratrol; D012639:Seeds / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*
D000975:Antioxidants; D013267:Stilbenes; D017665:Hydroxyl Radical; D003855:Deoxyribose; D000077185:Resveratrol