title: [Expression of proliferating cell nuclear antigen in craniopharyngioma and tumor recurrence].
abstract: OBJECTIVE
  To investigate proliferating cell nuclear antigen labeling indices (PCNA-LI) in craniopharyngiomas in association with tumor recurrence.
  
  
  METHODS
  Immunohistochemistry was employed to examine the expression of PCNA in 43 craniopharyngioma samples of different pathological types, and the relationship between PCNA-LI and tumor recurrence was evaluated.
  
  
  RESULTS
  PCNA-LI was much higher in adamantinous tumors than in squamous papillary tumors that did not give rise to postoperative recurrence. Although PCNA-LI was higher in the recurrent lesions than in the primary tumor in adamantinoma group, the difference was not statistically significant.
  
  
  CONCLUSIONS
  Craniopharyngioma cells with different pathological features may possess varied proliferating potentials, and active proliferation is the main factor for postoperative recurrence of adamantinoma.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Pan
authors.forename: Song-Tao
authors.initials: ST
authors.lastname: Qi
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Deng
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Ding
authors.forename: Lin
authors.initials: L
authors.lastname: Peng
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D012008:Recurrence
chemical_list: D018809:Proliferating Cell Nuclear Antigen