CD20-mediated apoptosis: signalling through lipid rafts.
CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.
Deans
Julie P
JP
Immunology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1. jdeans@ucalgary.ca
Li
Haidong
H
Polyak
Maria J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D018951:Antigens, CD20 / Q000235:genetics / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D006801:Humans; D021962:Membrane Microdomains / Q000276:immunology*; D008969:Molecular Sequence Data; D015398:Signal Transduction / Q000276:immunology*
D018951:Antigens, CD20