title: Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI.
abstract: MRI imaging of the rodent brain is a rapidly growing field in the neurosciences. Relatively limited information is available for regional volume determination. The present paper describes a reliable method for the assessment of the hippocampus, the anterior cingulate cortex, the retrosplenial granular cortex and the ventricles in rats. MRI scans were acquired using a 7 T magnet. The anatomical sampling method was found to be highly reliable with an intra-rater reliability of greater than 0.93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases.
authors.affiliation: Center for Brain Health, Neuroimaging Laboratory, NYU School of Medicine, New York, NY 10016, USA. oliver.wolf@uni-duesseldorf.de
authors.forename: O T
authors.initials: OT
authors.lastname: Wolf
authors.forename: V
authors.initials: V
authors.lastname: Dyakin
authors.forename: C
authors.initials: C
authors.lastname: Vadasz
authors.forename: M J
authors.initials: MJ
authors.lastname: de Leon
authors.forename: B S
authors.initials: BS
authors.lastname: McEwen
authors.forename: K
authors.initials: K
authors.lastname: Bulloch
mesh_terms: D000818:Animals; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D003337:Corpus Callosum / Q000033:anatomy & histology; D006179:Gyrus Cinguli / Q000033:anatomy & histology*; D006624:Hippocampus / Q000033:anatomy & histology*; D020547:Lateral Ventricles / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D015588:Observer Variation; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000033:anatomy & histology*; D015203:Reproducibility of Results