Juvenile dermatomyositis: immunogenetics, pathophysiology, and disease expression.
Data are rapidly accumulating documenting disease susceptibility may be linked to genetic markers (DQA1*0501 or related alleles) which are associated with upregulation of IFN-alpha/beta inducible genes elicited in response to an antigen which may be viral. Continued immune-mediated inflammation, resulting in partial lipodystrophy and pathological calcifications, may be fanned by the increased production of TNF alpha usually associated with the TNF alpha-308A allele.
Pachman
Lauren M
LM
Division of Immunology/Rheumatology, Department of Pediatrics, Children's Memorial Institute for Education and Research, Feinberg School of Medicine, Northwestern University, 2300 Children's Plaza, Box #50, Chicago, IL 60614, USA. pachman@nwu.edu
D001424:Bacterial Infections / Q000150:complications; D002114:Calcinosis; D002648:Child; D002675:Child, Preschool; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006403:Hematologic Tests; D006801:Humans; D007109:Immunity / Q000502:physiology; D008060:Lipodystrophy / Q000209:etiology; D008297:Male; D010272:Parasitic Diseases / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014777:Virus Diseases / Q000150:complications
D014409:Tumor Necrosis Factor-alpha