title: In vivo penicillin MIC drift to extremely high resistance in Serotype 14 Streptococcus pneumoniae persistently colonizing the nasopharynx of an infant with chronic suppurative lung disease: a case study.
abstract: This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics.
authors.affiliation: Menzies School of Health Research, Darwin, Northern Territory, Australia. amanda@menzies.edu.au
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Leach
authors.forename: Peter S
authors.initials: PS
authors.lastname: Morris
authors.forename: Heidi
authors.initials: H
authors.lastname: Smith-Vaughan
authors.forename: John D
authors.initials: JD
authors.lastname: Mathews
mesh_terms: D001991:Bronchitis / Q000382:microbiology; D002908:Chronic Disease; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology* / Q000627:therapeutic use; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy / Q000382:microbiology*; D012008:Recurrence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects*; D013997:Time Factors
chemical_list: D010406:Penicillins