title: Endoscopic botulinum toxin injection for cricopharyngeal dysphagia.
abstract: Twelve patients underwent 17 endoscopic injections of botulinum toxin type A in the cricopharyngeus muscle for the treatment of dysphagia and cricopharyngeal spasm over a 3-year period. The patient's charts were reviewed. Preoperative and postoperative symptoms, examination, and swallowing studies were reviewed. Eleven of the 12 patients had improvement in their symptoms, which lasted for a mean of 3.8 months. Two patients elected cricopharyngeal myotomy for permanent correction of their dysphagia. There was 1 case of postoperative neck cellulitis in an immunocompromised patient undergoing simultaneous excision of a thyroglossal duct cyst. We conclude that endoscopic injection of botulinum toxin is a relatively safe and viable technique for the treatment of dysphagia associated with cricopharyngeal spasm. It requires simple tools readily available to otolaryngologists. Larger, prospective controlled studies are necessary to establish its effectiveness and role in the management of this condition.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
authors.forename: Mahesh S
authors.initials: MS
authors.lastname: Parameswaran
authors.forename: Ahmed M S
authors.initials: AM
authors.lastname: Soliman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D003679:Deglutition; D003680:Deglutition Disorders / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D010609:Pharyngeal Muscles / Q000601:surgery; D013035:Spasm / Q000150:complications*; D013997:Time Factors
chemical_list: D019274:Botulinum Toxins, Type A