title: Herpes simplex virus colitis in a neonate.
abstract: Involvement of the gastrointestinal tract in neonates with congenital herpes simplex virus (HSV) infection is rarely described. We report a case of a newborn with disseminated HSV infection associated with profuse hematochezia and late sigmoid colon perforation. Histologic examination showed patchy areas of ulceration with multinucleated giant cells and HSV nucleic acid was detected by polymerase chain reaction in colonic tissue. No clinically apparent episodes of recurrent colitis occurred in the first year of life.
authors.affiliation: Departments of Immunology and Infectious Diseases, Royal Alexandra Hospital for Children, Westmead, Australia.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Daley
authors.forename: Paul
authors.initials: P
authors.lastname: Craven
authors.forename: Andrew J A
authors.initials: AJ
authors.lastname: Holland
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Jones
authors.forename: Nadia
authors.initials: N
authors.lastname: Badawi
authors.forename: David
authors.initials: D
authors.lastname: Isaacs
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D004760:Enterocolitis / Q000188:drug therapy / Q000821:virology*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006561:Herpes Simplex; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000821:virology*; D010406:Penicillins / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D005839:Gentamicins; D010406:Penicillins; D000667:Ampicillin; D000212:Acyclovir