title: Differential effects of carbamazepine on negatively versus positively reinforced responding.
abstract: To assess its effects on negatively versus positively reinforced operant behavior, carbamazepine (CBZ) or vehicle was acutely administered to rats. Negative reinforcement baselines consisted of a free-operant avoidance task with 5-s shock-shock and 20-s response-shock intervals. Positive reinforcement baselines consisted of responding for food pellets on a variable interval 30-s schedule. Ascending dose-effect functions were established using CBZ for negatively reinforced responding (vehicle, 25, 50, 100 mg/kg ip) and positively reinforced responding (vehicle, 12.5, 25, 50, 100 mg/kg ip). Negatively reinforced responses and avoided shocks were significantly reduced by CBZ injections at 100 mg/kg. Positively reinforced responses and food pellet deliveries were significantly reduced by CBZ injections at 25, 50, and 100 mg/kg. The results show that CBZ has differential, dose-dependent effects on negatively versus positively reinforced responding.
authors.affiliation: Department of Human Development and Family Life and Institute for Child Development, University of Kansas, Lawrence, KS 66044, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Caruso
authors.forename: Mark T
authors.initials: MT
authors.lastname: Harvey
authors.forename: Celeste
authors.initials: C
authors.lastname: Roberts
authors.forename: Tina G
authors.initials: TG
authors.lastname: Patterson
authors.forename: Craig H
authors.initials: CH
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001066:Appetite / Q000187:drug effects; D002220:Carbamazepine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012054:Reinforcement, Psychology
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine