sPECAM-1 in serum and CSF of acute ischaemic stroke patients.
OBJECTIVE
As platelet endothelial cell adhesion molecule-1 (PECAM-1) is one of key mediators of transendothelial migration of leucocytes during inflammation, and inflammatory reaction is observed in cerebral ischaemia, we decided to determine the levels of soluble PECAM-1 (sPECAM-1) in serum and cerebrospinal fluid (CSF) of patients with acute stroke.


METHODS
Twenty-three patients with first-ever in a lifetime completed ischaemic stroke have been studied. CSF and blood samples were obtained within 24 h of the onset of stroke and the levels of sPECAM-1 in serum and CSF were quantified by ELISA.


RESULTS
Stroke patients displayed statistically significant higher levels of sPECAM-1 in sera and CSF in comparison with control group. The levels were significantly higher in serum than in CSF, correlated between each other, and CSF sPECAM-1 fraction was blood-derived.


CONCLUSIONS
Our results indirectly suggest that PECAM-1 may play a role in the pathophysiological events during early phase of ischaemic stroke.
Zaremba
J
J
Department of Clinical Neuroimmunology, University School of Medicine, Poznan, Poland. jlosy@mail.usoms.poznan.pl
Losy
J
J
D000368:Aged; D000369:Aged, 80 and over; D001825:Body Fluid Compartments / Q000502:physiology; D002545:Brain Ischemia / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000502:physiology; D012995:Solubility; D020521:Stroke / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D013997:Time Factors
D019408:Platelet Endothelial Cell Adhesion Molecule-1