Insights from yeast endosomes.
The endosomal system of yeast is simpler than that of animal cells, but as it is mapped more similarities are emerging. A key role for ubiquitin in sorting proteins to and into multivesicular bodies has been demonstrated. The finding that Phox homology domains recognise phosphatidylinositol 3-phosphate explains how sorting nexins are recruited to endosomes, where they mediate the retrieval of membrane proteins from the endocytic pathway.
Pelham
Hugh R B
HR
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. hp@mrc-lmb.cam.ac.uk
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism / Q000502:physiology*; D006056:Golgi Apparatus / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D008954:Models, Biological; D021382:Protein Sorting Signals; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D002966:Clathrin; D021382:Protein Sorting Signals; D025801:Ubiquitin; D033921:Vesicular Transport Proteins