title: Somatic cell nuclear transfer.
abstract: Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
authors.affiliation: Roslin Institute, Roslin, Midlothian EH25 9PS, UK. ian.wilmut@bbsrc.ac.uk
authors.forename: I
authors.initials: I
authors.lastname: Wilmut
authors.forename: N
authors.initials: N
authors.lastname: Beaujean
authors.forename: P A
authors.initials: PA
authors.lastname: de Sousa
authors.forename: A
authors.initials: A
authors.lastname: Dinnyes
authors.forename: T J
authors.initials: TJ
authors.lastname: King
authors.forename: L A
authors.initials: LA
authors.lastname: Paterson
authors.forename: D N
authors.initials: DN
authors.lastname: Wells
authors.forename: L E
authors.initials: LE
authors.lastname: Young
mesh_terms: D000818:Animals; D002417:Cattle; D002453:Cell Cycle; D002454:Cell Differentiation; D019976:Cloning, Organism; D005314:Embryonic and Fetal Development; D005313:Fetal Death; D005544:Forecasting; D018507:Gene Expression Regulation, Developmental; D006041:Goats; D051379:Mice; D053652:Nuclear Transfer Techniques; D009865:Oocytes / Q000166:cytology; D011003:Ploidies; D012756:Sheep; D013552:Swine