Investigation of the genotoxic effect in bone marrow of Swiss albino mice exposed long-term to pyrimethamine.
In the present study, we investigated the genotoxic effect of pyrimethamine, which is a drug used in the therapy of toxoplasmosis and malaria, in bone marrow cells of Swiss albino mice exposed to three doses (1, 4, 8 mg/kg) of this agent for eight months orally in vivo. We used a chromosome analysis and micronucleus test for evaluation of genotoxic effect. While a statistically significant change was not determined in numerical chromosome abnormalities, structural chromosome aberrations and micronuclei were increased in a dose-dependent manner by cytogenetic and statistical evaluations.
Tunca
B
B
Department of Medical Biology and Genetics, Faculty of Medicine, University of Uludag, Bursa, Turkey.
Egeli
U
U
Aydemir
N
N
Cecener
G
G
Bilaloglu
R
R
D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens; D011739:Pyrimethamine / Q000633:toxicity*; D013997:Time Factors
D000962:Antimalarials; D009153:Mutagens; D011739:Pyrimethamine