Protective effect of topical iodine preparations upon heat-induced and hydrofluoric acid-induced skin lesions.
In this study, the protective prophylactic and post-exposure effects of novel topical iodine preparations were demonstrated upon heat- and hydrofluoric acid-induced skin lesions in the haired guinea pig. Prophylactic treatment of thermal bums with a liquid iodine preparation resulted in statistically significant reductions of 39% and 30%, respectively, in acute inflammation and hemorrhage-microscopic dermal parameters indicative of acute tissue damage. A clear trend of iodine-induced reduction in dermal necrosis occurred, and the epidermal healing markers, acanthosis and hyperkeratosis, were increased. Postexposure treatment of thermal burns with an iodine ointment preparation immediately after occurrence also conferred significant therapeutic reduction in parameters of tissue damage such as epidermal ulceration (87%), acute inflammation (58%), and hemorrhage (30%). Gross pathological evaluation showed that prophylactic and postexposure treatments with the liquid iodine preparation significantly reduced the heat-induced ulceration area by 97% and 65%, respectively. In addition, immediate treatment with an ointment iodine formulation significantly decreased the ulceration area by 98%; its tetraglycol vehicle also had a beneficial effect. Postexposure treatment with the iodine ointment proved efficacious upon hydrofluoric acid-induced skin burns. We observed statistically significant reductions of 76% and 68% in ulceration areas at intervals of 5 and 10 minutes between exposure and treatment, whereas a weaker effect was observed at a longer time interval of 15 minutes. Our findings suggest the therapeutic usage of these newly developed iodine preparations for thermally induced and hydrofluoric acid-induced skin burns.
Wormser
Uri
U
Faculty of Sciences, The Hebrew University, Givat Ram, Jerusalem, Israel. wormser@cc.huji.ac.il
Sintov
Amnon
A
Brodsky
Berta
B
Amitai
Yona
Y
Nyska
Abraham
A
D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D006168:Guinea Pigs; D006358:Hot Temperature / Q000009:adverse effects; D006858:Hydrofluoric Acid / Q000633:toxicity; D007455:Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
D000891:Anti-Infective Agents, Local; D020011:Protective Agents; D007455:Iodine; D006858:Hydrofluoric Acid