Mechanism for action of electromagnetic fields on cells.
A biophysical model for the action of oscillating electric fields on cells, presented by us before [Biochem. Biophys. Res. Commun. 272(3) (2000) 634-640], is extended now to include oscillating magnetic fields as well, extended to include the most active biological conditions, and also to explain why pulsed electromagnetic fields can be more active biologically than continuous ones. According to the present theory, the low frequency fields are the most bioactive ones. The basic mechanism is the forced-vibration of all the free ions on the surface of a cell's plasma membrane, caused by an external oscillating field. We have shown that this coherent vibration of electric charge is able to irregularly gate electrosensitive channels on the plasma membrane and thus cause disruption of the cell's electrochemical balance and function [Biochem. Biophys. Res. Commun. 272(3) (2000) 634-640]. It seems that this simple idea can be easily extended now and looks very likely to be able to give a realistic basis for the explanation of a wide range of electromagnetic field bioeffects.
Panagopoulos
Dimitris J
DJ
Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens GR-15784, Greece. dlpanagop@cc.uac.gr
Karabarbounis
Andreas
A
Margaritis
Lukas H
LH
D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000528:radiation effects; D002477:Cells / Q000528:radiation effects*; D004574:Electromagnetic Fields; D015640:Ion Channel Gating; D008962:Models, Theoretical; D014732:Vibration