COPII-dependent transport from the endoplasmic reticulum.
The coat protein complex II (COPII) forms transport vesicles from the endoplasmic reticulum and segregates biosynthetic cargo from ER-resident proteins. Recent high-resolution structural studies on individual COPII subunits and on the polymerized coat reveal the molecular architecture of COPII vesicles. Other advances have shown that integral membrane accessory proteins act with the COPII coat to collect specific cargo molecules into ER-derived transport vesicles.
Barlowe
Charles
C
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. barlowe@dartmouth.edu
D000818:Animals; D001692:Biological Transport; D022181:COP-Coated Vesicles / Q000378:metabolism* / Q000648:ultrastructure; D002352:Carrier Proteins / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D008954:Models, Biological; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism*
D002352:Carrier Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D020559:Monomeric GTP-Binding Proteins