title: Management of single fetal death in twin-to-twin transfusion syndrome: a role for fetal blood sampling.
abstract: OBJECTIVE
  Intrauterine death of one twin in monochorionic pregnancies is associated with an increased mortality and morbidity of the cotwin. This is likely to occur as a consequence of acute hemodynamic changes due to feto-fetal hemorrhage at the time of death of the cotwin. We assessed the role of fetal blood sampling and intrauterine transfusion to rescue the survivor.
  
  
  METHODS
  We managed 12 cases of single intrauterine death at between 17 and 26 weeks' gestation in monochorionic twins complicated by twin-to-twin transfusion syndrome (TTTS). All these cases had been treated either by laser therapy or by serial amniodrainage. When the demise of one twin occurred, ultrasound-guided fetal blood sampling was performed in the surviving twin using a 20-gauge needle within 24 h of death. Intrauterine transfusion was performed at the same time in cases where the survivor was anemic. All survivors were assessed in the neonatal period and at 1 year of age.
  
  
  RESULTS
  Six of the 12 surviving fetuses were found to be anemic and underwent intrauterine transfusion. All fetuses survived the procedure. Four of these fetuses had normal neurological development at 1 year of age. Periventricular leukomalacia developed in one case and the patient underwent termination of pregnancy at 34 weeks. In one case delivery occurred at 34 weeks' gestation and the baby developed periventricular leukomalacia at 1 month of age. In all six non-anemic fetuses pediatric examination was normal at birth and at 1 year of age.
  
  
  CONCLUSIONS
  Intrauterine death of one monochorionic twin in TTTS puts the survivor at high risk of intrauterine death or of developing ischemic/hypoxic lesions. Our results suggest that fetal blood sampling is a useful diagnostic tool to identify those fetuses that are not anemic and hence unlikely to be at risk of developing a cerebral lesion.
authors.affiliation: Department of Obstetrics and Gynecology, Paris-Ouest University, CHI Poissy-St-Germain, France.
authors.forename: M-V
authors.initials: MV
authors.lastname: Senat
authors.forename: J-P
authors.initials: JP
authors.lastname: Bernard
authors.forename: S
authors.initials: S
authors.lastname: Loizeau
authors.forename: Y
authors.initials: Y
authors.lastname: Ville
mesh_terms: D001800:Blood Specimen Collection; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal / Q000209:etiology / Q000628:therapy; D005260:Female; D005312:Fetal Blood; D005313:Fetal Death / Q000209:etiology / Q000517:prevention & control*; D005330:Fetofetal Transfusion / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D017075:Laser Coagulation; D007969:Leukomalacia, Periventricular / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome