The partner's role in the etiology of preeclampsia.
The etiology of preeclampsia is often considered to be purely maternal, i.e. maternal constitutional factors that impair maternal cardiovascular/endothelial mechanisms normally required to cope with the specific pregnancy demands, being primarily a generalised inflammatory response and a hyperdynamic circulation. Recent data strongly indicate an important role for the male partner in the causation of this common pregnancy disorder. The aim of this review is to discuss the relevant literature and to explain how paternal, relational and sexual factors play an important role in the etiology of preeclampsia.
Dekker
Gus
G
Department of Obstetrics and Gynaecology, University of Adelaide, Head Division of Obstetrics/Gynaecology and Paediatrics, North Western Adelaide Health Service, Lyell McEwin Hospital, Elizabeth Vale, SA, Australia. gustaaf.dekker@adelaide.edu.au
D005075:Biological Evolution; D005260:Female; D006680:HLA Antigens; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007316:Insemination, Artificial, Heterologous / Q000009:adverse effects; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology; D010290:Parents; D010298:Parity; D011225:Pre-Eclampsia / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D011247:Pregnancy; D012661:Semen / Q000276:immunology; D013094:Spermatozoa / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000096:biosynthesis
D006680:HLA Antigens; D018836:Inflammation Mediators; D016212:Transforming Growth Factor beta