title: A genetic view of iron homeostasis.
abstract: Inherited disorders of iron metabolism are invariably disorders of iron balance or distribution. This review describes the proteins known to be involved in establishing and maintaining iron balance, and discusses regulation of iron homeostasis in the context of three cell types: intestinal enterocytes, reticuloendothelial macrophages, and hepatocytes. It emphasizes information gleaned from the use of genetic analyses, particularly in mice, and poses new questions to help advance our understanding of iron balance.
authors.affiliation: Howard Hughes Medical Institute, the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Nancy C
authors.initials: NC
authors.lastname: Andrews
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000235:genetics; D020895:Enterocytes / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000235:genetics; D008264:Macrophages / Q000378:metabolism
chemical_list: D007501:Iron