title: The antimicrobial activity of Aspergillus fumigatus is enhanced by a pool of bacteria.
abstract: In a screening program for new antibiotic producers, a strain of Aspergillus fumigatus was isolated from Brazilian soil samples. A pool of autoclaved bacteria was added to part of the fungus culture on the second day of fermentation to increase antibiotic production. The chloroform extract from the culture broth to which the pool of autoclaved bacteria was added showed an increase of 55%, 63% and more than 100% in activity against Staphylococcus aureus, Candida albicans and Micrococcus luteus, respectively. Also, the HPLC chromatographic profiles of the chloroform extracts from both culture conditions were different. Two active compounds were isolated from the broth of the culture grown in the presence of pooled bacteria and were identified as 3,4-dimethoxyphenol and 1,3,5-trimethoxybenzene.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brazil.
authors.forename: Niege Araçari Jacometti Cardoso
authors.initials: NA
authors.lastname: Furtado
authors.forename: Suraia
authors.initials: S
authors.lastname: Said
authors.forename: Izabel Yoko
authors.initials: IY
authors.lastname: Ito
authors.forename: Jairo Kenupp
authors.initials: JK
authors.lastname: Bastos
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D001428:Bacterial Vaccines / Q000008:administration & dosage; D001938:Brazil; D002176:Candida albicans / Q000187:drug effects; D016982:Micrococcus luteus / Q000187:drug effects; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines