Chemical-shift MR imaging of acetic acid during percutaneous chemical ablation therapy: preliminary work.
The purpose of this study was to test the hypothesis that chemical-shift magnetic resonance (MR) imaging may be used to map the distribution of acetic acid during percutaneous chemical ablation procedures. Chemical-shift MR imaging was performed with use of standard methods on a 1.5-T scanner. Phantom and ex-vivo data demonstrated focal increases in the observed signal in chemical-shift MR imaging that correlate well with the site of injection. Preliminary study in a patient with hepatoma revealed focal signal at the injection site. These preliminary results suggest that chemical-shift MR imaging may be used to visualize acetic acid distribution during percutaneous chemical ablation procedures.
Roberts
David A
DA
Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania 19104-4283, USA. roberst@rad.upenn.edu
Rosen
Marc A
MA
Clark
Timothy W I
TW
Mondschein
Jeffrey
J
Soulen
Michael C
MC
Siegelman
Evan
E
Leigh
John S
JS
D019342:Acetic Acid / Q000008:administration & dosage*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D002417:Cattle; D003287:Contrast Media; D005682:Gadolinium; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D019047:Phantoms, Imaging
D003287:Contrast Media; D005682:Gadolinium; D019342:Acetic Acid