Pharmacogenomics: the future of drug therapy.
Pharmacogenomics aims to optimize patient management by customizing and synthesizing drugs based on genetic variations in drug response. Polymorphisms affecting metabolism, receptors, and absorption can influence drug sensitivity, toxicity, and dosing. The Human Genome Project, DNA chips, and bioinformatics advance the practice of this field by, respectively, identifying polymorphisms related to drug response, determining an individual's profile of polymorphisms, and integrating data to facilitate clinical decision making. Potential benefits of pharmacogenomics include increasing efficacy and preventing adverse drug reactions, thus improving patient care and decreasing costs. These factors imply that a thorough understanding of the principles and applications of pharmacogenomics will be an indispensable part of the future of drug therapy in clinical medicine.
Tsai
Y J
YJ
Department of Medicine, St Joseph's Mercy Hospital, Ann Arbor, MI, USA.
Hoyme
H E
HE
D019295:Computational Biology; D015195:Drug Design; D004358:Drug Therapy / Q000639:trends*; D015894:Genome, Human; D006801:Humans; D010600:Pharmacology; D011110:Polymorphism, Genetic