[Expression of immediate-early genes c-fos and c-jun in the marginal division of striatum during learning and memory].
OBJECTIVE
To study the expression of immediate-early genes c-fos and c-jun in the marginal division (MrD) of rat striatum during learning and memory.


METHODS
After Y-maze training in rats, the expression of immediate-early genes c-fos and c-jun in the MrD was investigated immunocytochemically.


RESULTS
After 1 h of Y- maze training, the expression of c-Fos and c-Jun proteins was significantly enhanced in the MrD, where c-Jun protein in particular was more intensely expressed than in other parts of the striatum. The training group showed significantly higher expressions of the 2 proteins than pseudotraining group (P<0.01). In addition, positive expression was also observed in the hippocampus, cingulum cortex and other parts of the brain.


CONCLUSIONS
Immediate-early genes c-fos and c-jun in the MrD participate in the signal transduction during learning and memory processes in the courses of Y-maze training of the rats.
Wang
Hong
H
Institute for Neuroscience, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Shu
Si-Yun
SY
Bao
Xin-Min
XM
Yang
Wen-Ke
WK
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D015870:Gene Expression; D017781:Genes, Immediate-Early / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun