Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants.
In an attempt to address the issue of cytogenetic features of multiple myeloma (MM) variants, we have analyzed a series of 8 IgM, 9 IgD, 2 IgE, and 14 nonsecretory (NS) MM cases using fluorescence in situ hybridization. A very high incidence (83%) of t(11;14)(q13;q32) was detected in the IgM (7 of 8), IgE (2 of 2), and NS (11 of 14) MM cases, but not in the IgD cases (2 of 9). Of note, no t(4;14) was observed in this cohort of patients. This increased incidence of t(11;14) was associated with 2 dominant features in these variants, namely, a "lymphoplasmacytic" presentation mainly in IgM MM and a lower secreting capacity in the others, 2 features previously associated with t(11;14). Of major interest, t(11;14) was never observed in Waldenström macroglobulinemia or in IgG/IgA "lymphoplasmacytic" lymphomas. Thus, for unknown reasons, t(11;14) is the hallmark of IgM, IgE, and NS MM, (but not IgD MM), with a 5-fold increase of its incidence compared to that of IgG and IgA MM.
Avet-Loiseau
Hervé
H
Laboratory of Hematology, University Hospital, Nantes, France. havetloiseau@chunantes.fr
Garand
Richard
R
Lodé
Laurence
L
Harousseau
Jean-Luc
JL
Bataille
Régis
R
D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D007072:Immunoglobulin D / Q000235:genetics; D007073:Immunoglobulin E / Q000235:genetics*; D007075:Immunoglobulin M / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D009101:Multiple Myeloma / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D014178:Translocation, Genetic; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics
D007072:Immunoglobulin D; D007075:Immunoglobulin M; D007073:Immunoglobulin E