A copper connection to the uptake of platinum anticancer drugs.
Nitiss
John L
JL
Molecular Pharmacology Department, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA. john.nitiss@stjude.org
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology; D027682:Cation Transport Proteins; D002570:Ceruloplasmin / Q000235:genetics / Q000378:metabolism; D002945:Cisplatin / Q000378:metabolism* / Q000494:pharmacology; D003300:Copper / Q000378:metabolism*; D000079923:Copper Transporter 1; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010984:Platinum / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D000970:Antineoplastic Agents; C490078:CTR1 protein, S cerevisiae; D027682:Cation Transport Proteins; D000079923:Copper Transporter 1; D005656:Fungal Proteins; C084954:MAC1 protein, S cerevisiae; D008565:Membrane Proteins; D018832:Molecular Chaperones; D009687:Nuclear Proteins; C490079:SLC31A1 protein, human; C000606290:SOD1 protein, human; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D010984:Platinum; D003300:Copper; C095735:LYS7 protein, S cerevisiae; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D002570:Ceruloplasmin; C085513:FET3 protein, S cerevisiae; D000251:Adenosine Triphosphatases; D002945:Cisplatin