title: Effect of Timolol vs. a postural orthotic on hand tremor during microsurgery.
abstract: The efficacy of beta blockers to control hand tremor remains equivocal. This study evaluated the effectiveness of Timolol, as well as a postural orthotic, in reducing movement deviation during a laboratory exercise. Eleven volunteers completed three randomized trials involving administration of Timolol, a placebo, or a postural orthotic. Drug administration was blinded. Each trial consisted of a simulated 2-hr clinical procedure, punctuated by video recordings of the subject's hand motion during a standardized pattern of instrument movement. ECRL EMG activity and digital oxygen perfusion were also measured. Recordings were converted into estimates of linear variance at baseline and 1 and 2 hr. A repeated-measures ANOVA, or the Friedman test, were used to assess significant differences. Movement deviation, EMG activity, and oxygen perfusion were unaffected by the duration of exercise or treatment (P > or = 0.454). We conclude that none of the treatments accorded a significant benefit in allaying hand tremor.
authors.affiliation: Department of Orthopaedics, Hamot Medical Center, 201 State Street, Erie, PA 16550, USA. jdl@erie.net
authors.forename: John D
authors.initials: JD
authors.lastname: Lubahn
authors.forename: Brian G
authors.initials: BG
authors.lastname: Dickson
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Cooney
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006225:Hand / Q000502:physiology; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009989:Orthotic Devices; D011187:Posture / Q000502:physiology; D013999:Timolol / Q000627:therapeutic use*; D014202:Tremor / Q000517:prevention & control*
chemical_list: D000319:Adrenergic beta-Antagonists; D013999:Timolol