title: Role of Oncogenic Transcription Factor c-Myc in Cell Cycle Regulation, Apoptosis and Metabolism.
abstract: The myc gene was initially discovered as a prototypical retrovirally transduced oncogene. Over the decades, abundant evidence has emerged to support a causal role for the activated cellular gene, c-myc, in animal and human tumors. The gene encodes an oncogenic helix-loop-helix leucine zipper transcription factor that acts as a heterodimer with its partner protein, Max, to activate genes regulating the cell cycle machinery as well as critical metabolic enzymes. The additional ability of c-Myc to repress transcription of differentiation-related genes suggest that c-Myc is a central and key molecular integrator of cell proliferation, differentiation and metabolism.
authors.affiliation: Departments of Medicine, Oncology, Pathology, and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Md., USA.
authors.forename: C.V.
authors.initials: CV
authors.lastname: Dang
authors.forename: B.C.
authors.initials: BC
authors.lastname: Lewis