[Diagnostic use of gene polymorphism for type 2 diabetes].
Type 2 diabetes is thought be a multifactorial disease and both genetic and acquired factors contribute its pathogenesis. Elucidation of susceptibility genes for type 2 diabetes thus leads to primary prevention for the disease. Although main susceptibility genes for type 2 diabetes have not been found, I present our data using candidate gene approach. Our data include the amylin gene S20G and the Pax4 gene R121W mutations and also include the muscle glycogen synthase gene M416V polymorphism that correlates to insulin resistance as a thrifty gene.
Sanke
Tokio
T
Department of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama 641-8509.
D000682:Amyloid / Q000235:genetics; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006006:Glycogen Synthase / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D058228:Islet Amyloid Polypeptide; D009154:Mutation; D051761:Paired Box Transcription Factors; D011110:Polymorphism, Genetic; D014157:Transcription Factors / Q000235:genetics
D000682:Amyloid; D018398:Homeodomain Proteins; D058228:Islet Amyloid Polypeptide; C491709:PAX4 protein, human; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; D006006:Glycogen Synthase