Residual differences in language processing in compensated dyslexics revealed in simple word reading tasks.
Using regional cerebral blood flow as an index of cerebral activity we studied dyslexic and control subjects during simple word reading tasks. The groups were pre-tested for reading skill and the dyslexic group had a lower reading performance but could read and comprehend standard texts. The aim was to elucidate differences in the cerebral activation pattern during reading. The tasks were simple enough that performance differences between the groups could be excluded. We found specific differences between the two groups that were dependent on the language task. When the visual route for language information was used, minor qualitative differences were found between the groups pertaining to the dominant hemisphere. Increasing the complexity of the task by using pseudowords activated the left frontal region more in the dyslexic group than in the control group. A similar effect was seen in a minor region in extrastriate lateral occipital cortex (BA 19). This finding indicates that the dyslexics used areas in these regions that the controls did not. On the other hand, the dyslexics activated less in the right angular gyrus, right dorsolateral prefrontal cortex, and in the right pallidum. Reading skill correlated with the level of activity in the right frontal cortex. We conclude, that cerebral activation pattern elicited by reading is different in dyslexics compared to controls in spite of an almost complete functional compensation.
Ingvar
Martin
M
Department of Clinical Neurophysiology, Section of Cognitive Neurophysiology, Karolinska Hospital, Stockholm 104 01, Sweden. martin.ingvar@ks.se
af Trampe
Peter
P
Greitz
Torgny
T
Eriksson
Lars
L
Stone-Elander
Sharon
S
von Euler
Curt
C
D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D004410:Dyslexia / Q000175:diagnosis*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007802:Language; D008297:Male; D009778:Occipital Lobe / Q000098:blood supply*; D017397:Prefrontal Cortex / Q000098:blood supply*; D014055:Tomography, Emission-Computed; D014796:Visual Perception / Q000502:physiology; D014825:Vocabulary