A platform for compartmentalized protein synthesis: protein translation and translocation in the ER.
Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the regulation of protein-conducting-channel permeability during membrane protein integration. A hypothesis identifying the endoplasmic reticulum as a site of mRNA localization and compartmentalized protein synthesis has been suggested.
Nicchitta
Christopher V
CV
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. c.nicchitta@cellbio.duke.edu
D001693:Biological Transport, Active; D002451:Cell Compartmentation; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D014176:Protein Biosynthesis; D021382:Protein Sorting Signals; D021381:Protein Transport; D012333:RNA, Messenger / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
D008565:Membrane Proteins; D021382:Protein Sorting Signals; D012333:RNA, Messenger