Advances in Burkholderia cepacia complex.
Burkholderia cepacia is an important opportunistic pathogen in certain compromised hosts, particularly those with either cystic fibrosis (CF) or chronic granulomatous disease. The "family" of bacteria known as B. cepacia is highly heterogeneous and is composed of at least nine discrete species or genomovars, constituting the B. cepacia complex. Bacteria from the B. cepacia complex are particularly virulent in susceptible hosts, often causing necrotising invasive infection and death. Whereas the microbial determinants of virulence in B. cepacia complex are currently not defined, the bacteria appear to have features facilitating survival within host cells. Burkholderia cepacia is highly resistant to antibiotics and to neutrophil-mediated non-oxidative killing; infection should be treated with combination antimicrobial therapy. Burkholderia cepacia can spread from one CF patient to another. Transmission appears to be facilitated by close personal contact and by certain bacterial factors.
Speert
David Paul
DP
Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia and British Columbia's Children's and Women's Health Centre and the Canadian Bacterial Diseases Network, Research Centre, Vancouver, BC, Canada.
D000900:Anti-Bacterial Agents; D015373:Bacterial Typing Techniques; D018441:Biofilms; D019121:Burkholderia Infections / Q000188:drug therapy / Q000635:transmission; D016956:Burkholderia cepacia / Q000145:classification / Q000302:isolation & purification; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000382:microbiology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000382:microbiology; D006801:Humans; D014774:Virulence
D000900:Anti-Bacterial Agents