title: Perfusion and molecular diffusion-weighted MR imaging of the brain: in vivo assessment of tissue alteration in cerebral ischemia.
abstract: The combined use of perfusion imaging (PI) and diffusion-weighted imaging (DWI) is opening a new window into the processes that occur during the first hours of ischemia. DWI detects changes in molecular diffusion associated with cytotoxic edema. PI characterizes the degree of regional hypoperfusion. Regions showing mismatches between DWI and PI, i.e. hypoperfused areas with normal diffusion behavior are considered potentially salvageable. We present results of 11 patients with an occlusion of the middle cerebral artery stem and spontaneous stroke evolution. Whereas the infarct was clearly visible on initial DWI and PI, surrounding tissue at risk of infarction was marked in all patients by an increased blood volume and transit time, but only in a subgroup (n = 3) where alteration were more pronounced this tissue at risk was progressively infarcted. These human DWI and PI data show alterations in the area of tissue at risk which correlates with infarct progression.
authors.affiliation: Department of Radiology, University of Bonn, Bonn, Germany. flacke@uni-bonn.de
authors.forename: S
authors.initials: S
authors.lastname: Flacke
authors.forename: H
authors.initials: H
authors.lastname: Urbach
authors.forename: W
authors.initials: W
authors.lastname: Block
authors.forename: F
authors.initials: F
authors.lastname: Träber
authors.forename: P
authors.initials: P
authors.lastname: Mürtz
authors.forename: E
authors.initials: E
authors.lastname: Keller
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: H H
authors.initials: HH
authors.lastname: Schild
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged