title: Improved diagnosis of advanced bone marrow metastases by means of radiolabeled antigranulocyte antibodies.
abstract: Assessment of bone marrow metastases using Tc-99m-labeled antigranulocyte antibodies and Tc-99m-labeled nanocolloids is discussed in osseous metastasizing breast cancer. A 53-year-old patient with bone metastases of breast cancer (pT2 pN1biv cM1) developed leukocytopenia WHO Grade III following polychemotherapy. Bone marrow scintigraphy with Tc-99m labeled nanocolloids and Tc-99m-labeled antigranulocyte antibodies revealed pronounced bone marrow infiltration as the cause. Comparing both procedures, the images with antigranulocyte antibodies showed a clearly better bone marrow image, considerably higher contrast and almost no superimposition of the liver over the spine. In osseous metastasizing breast cancer, scintigraphy with Tc-99m-labeled antigranulocyte antibodies enables assessment of metastases in the entire bone marrow.
authors.affiliation: Dept. of Nuclear Medicine, University Hospital Bonn, Germany.
authors.forename: D
authors.initials: D
authors.lastname: von Mallek
authors.forename: A
authors.initials: A
authors.lastname: Joe
authors.forename: H
authors.initials: H
authors.lastname: Palmedo
authors.forename: A
authors.initials: A
authors.lastname: Matthies
authors.forename: H J
authors.initials: HJ
authors.lastname: Biersack
authors.forename: M J
authors.initials: MJ
authors.lastname: Reinhardt
mesh_terms: D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging* / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016719:Radioimmunodetection / Q000379:methods; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013669:Technetium Tc 99m Medronate
chemical_list: D007074:Immunoglobulin G; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate