title: [Cholinergic modulation of neuronal spike reactions to dendritic and somatic application of excitatory acids].
abstract: Acetylcholine effects on neuronal firing responses evoked by somatic or dendritic applications of excitatory amino acids were studied in slices of guinea-pig parietal cortex. Excitatory reactions initiated by dendritic activation were enhanced by acetylcholine wherever it was iontophoretically applied: either to soma or dendrites. The effect consisted in shortening spike response latencies and increasing response intensity and duration. The modified responses were recorded within 1-min interval after acetylcholine microinjections at a distance within 300 microns of the soma. Parameters of responses to somatic applications of excitatory amino acids were not significantly changed by acetylcholine. The results suggest that acetylcholine improves dendritic propagation rather than membrane excitability.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Mednikova
authors.forename: S V
authors.initials: SV
authors.lastname: Karnup
authors.forename: M N
authors.initials: MN
authors.lastname: Zhadin
mesh_terms: D000109:Acetylcholine / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D003712:Dendrites / Q000187:drug effects / Q000502:physiology*; D018846:Excitatory Amino Acids / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D018846:Excitatory Amino Acids; D000109:Acetylcholine