A review of nerve agent exposure for the critical care physician.
Nerve agents are discussed. The article discusses their properties, routes of exposure, toxicodynamics, targets of toxicity, and treatment. It is concluded that a focused organized approach to the treatment of nerve agents is key to its successful management.
Leikin
Jerrold B
JB
Evanston Northwestern Healthare OMEGA, Glenbrook Hospital, Glenview, IL, USA. jleikin@enh.org
Thomas
Richard G
RG
Walter
Frank G
FG
Klein
Raymond
R
Meislin
Harvey W
HW
D000931:Antidotes / Q000627:therapeutic use; D002619:Chemical Warfare Agents / Q000737:chemistry / Q000506:poisoning; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000506:poisoning; D003666:Decontamination / Q000379:methods; D006801:Humans; D009420:Nervous System / Q000187:drug effects; D062025:Organophosphate Poisoning; D010755:Organophosphates / Q000737:chemistry; D009946:Organothiophosphorus Compounds / Q000737:chemistry / Q000506:poisoning; D012524:Sarin / Q000737:chemistry / Q000506:poisoning; D012999:Soman / Q000737:chemistry / Q000506:poisoning
D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D010755:Organophosphates; D009946:Organothiophosphorus Compounds; D012524:Sarin; D012999:Soman; C009680:VX-agent; C009374:tabun