Expression and role of retinoic acid receptor alpha in lens regeneration.
The role of retinoids in eye development has been well studied. Retinoids and their receptors regulate gene expression and morphogenesis of the eye. In this study, a highly specific antagonist of retinoic acid receptor (RAR)-alpha was used in an attempt to study its function in lens regeneration. It was found that this antagonist inhibited lens regeneration and lens fiber differentiation. It was also shown that RAR-alpha is expressed in the lens during the process of regeneration. These results indicate that different RAR might have unique as well as redundant effects and patterns of expression in the regenerating lens.
Tsonis
Panagiotis A
PA
Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, OH 45469-2320, USA. Panagiotis.Tsonis@notes.udayton.edu
Tsavaris
Melissa
M
Call
Mindy K
MK
Chandraratna
Roshantha A S
RA
Del Rio-Tsonis
Katia
K
D000818:Animals; D002455:Cell Division / Q000502:physiology; D015536:Down-Regulation; D007498:Iris / Q000502:physiology; D007908:Lens, Crystalline / Q000502:physiology*; D009673:Notophthalmus viridescens; D018168:Receptors, Retinoic Acid / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D000072482:Retinoic Acid Receptor alpha
D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha