Attachment of neutrals during tandem mass spectrometry of sulfonic acid dyes and intermediates in an ion trap.
Several positional isomers of 2-(2-quinolinyl)-1H-indene-1,3(2H)-dione mono- and disulfonic acids prepared as reference materials for development of analytical methods involved in FDA certification of D&C Yellow No. 10 (Quinoline Yellow) were found consistently to show [MH + 14](+) ions when their electrospray- or atmospheric pressure chemical ionization-prepared MH(+) ions were subjected to collisional activation. The source of these ions was found to be the methanol used as solvent in these procedures which combined with their [MH - H(2)O](+) ions under chemical ionization conditions. The reaction was found to be sensitive to their isomeric and chemical structures and other examples of this process are reviewed.
Weisz
Adrian
A
Office of Cosmetics and Colors, US Food and Drug Administration, Washington, DC 20204, USA. aweisz@cfsan.fda.gov
Andrzejewski
Denis
D
Fales
Henry M
HM
Mandelbaum
Asher
A
D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents / Q000032:analysis*; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D011804:Quinolines; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013451:Sulfonic Acids / Q000032:analysis*
D004396:Coloring Agents; D007202:Indicators and Reagents; D011804:Quinolines; D012997:Solvents; D013451:Sulfonic Acids; C019303:quinoline yellow