Viewpoint on the functionality of the human leukocyte antigen-G null allele at the fetal-maternal interface.
The description of healthy individuals homozygous for the human leukocyte antigen-G (HLA-G) null allele raised doubts about the role of HLA-G in fetal-maternal tolerance. In light of recent results, we discuss this point by considering the potential activity of this null allele that might, indeed, produce functional truncated HLA-G molecules. In this context, we have recently described that, like the full-length HLA-G1, the HLA-G2, -G3, and -G4 truncated isoforms may be expressed at the cell surface and may modulate both innate and acquired immune responses.
Moreau
Philippe
P
Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital St-Louis, Institut Universitaire d'Hématologie, 75475 Paris, Cedex 10, France.
Dausset
Jean
J
Carosella
Edgardo D
ED
Rouas-Freiss
Nathalie
N
D000483:Alleles; D005260:Female; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007112:Immunity, Maternally-Acquired; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D020033:Protein Isoforms / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014327:Trophoblasts / Q000276:immunology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D020033:Protein Isoforms