[Food-grade gene expression systems for lactic acid bacteria].
Lactic acid bacteria (LAB) are important industrial microorganism used in the production and preservation of food-stuffs. Recently, considerable advances have been made in the genetics and molecular biology of LAB. These have resulted in the construction of food-grade gene expression systems for these bacteria. This paper aims to review the essential features for food-grade systems, food-grade selection markers, food-grade controlled gene expression and food-grade inducible signaling molecule, and recent developments on food-grade cloning and expression systems for LAB. These gene expression systems have great potential for studies on gene expression and regulation in LAB and a variety of bioprocessing application in industrial fermentations.
Zhang
Zhen-Zhong
ZZ
Research Center for Molecular Microbiology, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China.
Chen
Xiu-Zhu
XZ
Jia
Shi-Fang
SF
Chen
Mei-Ling
ML
Huan
Lian-Dong
LD
D019649:Food Industry / Q000379:methods / Q000592:standards; D005516:Food Microbiology; D015964:Gene Expression Regulation, Bacterial; D013294:Lactococcus lactis / Q000235:genetics* / Q000254:growth & development