Fifty years of the Hodgkin-Huxley era.
Modern neuroscientists are accustomed to the detailed information on the structure and function of membrane ion channels that can be obtained by the combination of molecular biology, crystallography and patch-clamp recordings. It can be difficult for us to appreciate how hard it was for humankind to realize that physical events underlie nervous function and, moreover, to appreciate how long it took to devise a realistic model for the generation and propagation of the nerve impulse.
Piccolino
Marco
M
Dept of Biology and Center of Neurosciences, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy. marco.piccolino@unife.it
D000818:Animals; D004594:Electrophysiology / Q000266:history*; D004739:England; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D007473:Ion Channels / Q000266:history*; D018408:Patch-Clamp Techniques / Q000266:history*
D007473:Ion Channels