title: Effective artificial proteases synthesized by covering silica gel with aldehyde and various other organic groups.
abstract: Organic artificial proteases with broad substrate specificity were synthesized by covering the surface of silica gel with aldehyde and the functional groups present in amino acids. The artificial proteases hydrolyzed ovalbumin, albumin, hemoglobin, gamma-globulin with half-lives as short as 50 min at 25 degrees C or 7 min at 50 degrees C.
authors.affiliation: School of Chemistry and Center for Molecular Catalysis, Seoul National University, Republic of Korea.
authors.forename: Hyunsook
authors.initials: H
authors.lastname: Kim
authors.forename: Myoung-soon
authors.initials: MS
authors.lastname: Kim
authors.forename: Hyesun
authors.initials: H
authors.lastname: Paik
authors.forename: Yeon-Sook
authors.initials: YS
authors.lastname: Chung
authors.forename: In Seok
authors.initials: IS
authors.lastname: Hong
authors.forename: Junghun
authors.initials: J
authors.lastname: Suh
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D002384:Catalysis; D010450:Endopeptidases / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D018716:Molecular Mimicry; D009930:Organic Chemicals / Q000737:chemistry; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D058428:Silica Gel; D012822:Silicon Dioxide; D013379:Substrate Specificity
chemical_list: D000447:Aldehydes; D009930:Organic Chemicals; D011506:Proteins; D058428:Silica Gel; D012822:Silicon Dioxide; D010450:Endopeptidases