title: New approaches to raising the HDL cholesterol level.
abstract: Not only a high level of low-density lipoprotein (LDL) cholesterol, but also a low level of high-density lipoprotein (HDL) cholesterol, is a critical risk factor for atherosclerosis and coronary heart disease. Although fibrates and niacin can be used to improve low HDL cholesterol levels, their effect is not wholly satisfactory, so better drugs for the elevation of HDL cholesterol are desired. Among the many methods that may be used to raise HDL cholesterol levels, this review focuses on inhibitors of cholesteryl ester transfer protein (CETP) and on nuclear orphan receptor agonists that mediate the expression of ATP-binding cassette transporter 1 (ABC1).
authors.affiliation: Central Pharmaceutical Research Institute, JT Inc., 1-1 Murasaki-cho, Takatsuki, Osaka, 569-1125, Japan. hisashi.shinkai@ims.jti.co.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shinkai
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000819:agonists / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006023:Glycoproteins; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists; D015854:Up-Regulation / Q000187:drug effects
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D004791:Enzyme Inhibitors; D006023:Glycoproteins; D018160:Receptors, Cytoplasmic and Nuclear