Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers.
BACKGROUND
Flesinoxan is a highly potent and selective 5-HT(1A) agonist and appears to be a potentially interesting neuroendocrine serotonergic probe.


OBJECTIVE
We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers.


METHODS
In a double-blind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min.


RESULTS
Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent.


CONCLUSIONS
These results showed the role of 5-HT(1A) mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.
Pitchot
William
W
Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium. wpitchot@chu.ulg.ac.be
Wauthy
Jacques
J
Hansenne
Michel
M
Pinto
Emmanuel
E
Fuchs
Sonia
S
Reggers
Jean
J
Legros
Jean-Jacques
JJ
Ansseau
Marc
M
D000328:Adult; D019540:Area Under Curve; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010907:Pituitary Hormones / Q000097:blood*; D011985:Receptors, Serotonin / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D018709:Statistics, Nonparametric
D010879:Piperazines; D010907:Pituitary Hormones; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; C056895:flesinoxan; D006854:Hydrocortisone