Overexpressed differentiation antigens as targets of graft-versus-leukemia reactions.
The graft-versus-leukemia (GVL) effect associated with allogeneic blood and marrow transplantation has largely been a clinically described phenomenon until recently. We are beginning to understand the cellular and molecular nature of GVL, and in this review the authors highlight the potential for self-antigen-specific T lymphocytes to contribute to GVL. The authors focus on myeloid tissue-restricted proteins as GVL target antigens in CML and AML, and in particular on proteinase 3 and other azurophil granule proteins as targets for both autologous and allogeneic T-cell responses. Finally, the authors discuss myeloid self-antigen-directed alloreactivity in the context of our evolving understanding of the critical molecular determinants of allogeneic T-cell recognition. By altering T-cell receptor affinity, peptide specificity can be maintained and the potency of immunity can be enhanced in the MHC-mismatched setting.
Molldrem
Jeffrey J
JJ
Transplantation Immunology Section, Department of Blood and Marrow Transplantation, University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA. jmolldre@notes.mdacc.tmc.edu
Komanduri
Krishna
K
Wieder
Eric
E
D000943:Antigens, Differentiation / Q000276:immunology / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology / Q000627:therapeutic use; D020544:Graft vs Leukemia Effect / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007951:Leukemia, Myeloid / Q000276:immunology / Q000628:therapy; D017710:Lymphocyte Transfusion; D014184:Transplantation, Homologous / Q000379:methods
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm