Oral administration of a novel chymase inhibitor, NK3201, prevents peritoneal adhesion formation in hamsters.
We investigated the preventive effect of an orally active chymase inhibitor, NK3201 (2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2heptyl]acetamide), on the adhesion formation in a hamster experimental model. Hamsters were administered orally once daily with 30 mg/kg of NK3201 or placebo from 3 days before uterus scraping to 7 days after it. A significant increase of chymase activity in the injured uterus was reduced by treatment with NK3201. The score of adhesion formations in the chymase inhibitor-treated group was significantly decreased in comparison with that in the placebo-treated group (P < 0.01). Oral administration of NK3201 may be a useful drug for prevention of peritoneal adhesion formation.
Okamoto
Yukiko
Y
Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan.
Takai
Shinji
S
Miyazaki
Mizuo
M
D000081:Acetamides / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D053818:Chymases; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D008407:Mast Cells / Q000187:drug effects* / Q000201:enzymology; D008647:Mesocricetus; D010529:Peritoneal Cavity / Q000502:physiology; D011743:Pyrimidines / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects / Q000201:enzymology
D000081:Acetamides; D004791:Enzyme Inhibitors; C437945:NK3201; D011743:Pyrimidines; D012697:Serine Endopeptidases; D053818:Chymases