title: Clinical trials and "real-world" medicine. Trial evidence best informs real-world medicine when it is relevant to the clinical problem.
authors.forename: R John
authors.initials: RJ
authors.lastname: Simes
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D010358:Patient Participation; D016032:Randomized Controlled Trials as Topic / Q000191:economics / Q000379:methods*; D015203:Reproducibility of Results