[Renoprotective effect of angiotensin II receptor blocker--does blood pressure play a pivotal role?].
Several recent randomized trials and clinical studies demonstrated that as well as angiotensin converting enzyme inhibitors angiotensin II receptor blockers(ARB) exerted renoprotective effect on diabetic and non-diabetic nephropathy. This renoprotective effect appears to be independent of the reduction of blood pressure, and be derived mainly from the suppression of renal renin-angiotensin system. Several mechanisms have been proposed regarding this renoprotective effect of ARB; e.g. hemodynamic effect in the intraglomerular pressure, reduction of proteinuria, decrease of collagen formation. Further investigation is required to clarify the precise mechanism.
Ueno
Michio
M
National Kyushu Medical Center.
D057911:Angiotensin Receptor Antagonists; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*
D057911:Angiotensin Receptor Antagonists