title: Evaluation of Brucella abortus strain RB51 and strain 19 in pronghorn antelope.
abstract: Free-roaming elk and bison in the Greater Yellowstone Area remain the only wildlife reservoirs for Brucella abortus in the United States, and the large number of animals and a lack of holding facilities make it unreasonable to individually vaccinate each animal. Therefore, oral delivery is being proposed as a possible option to vaccinate these wild ungulates. One of the main problems associated with oral vaccination is the potential exposure of nontarget species to the vaccines. The purpose of this study was to determine the effects of two Brucella vaccines, strain 19 (S19) and the rough strain RB51 (SRB51), in pregnant pronghorn antelope. We conclude that S19 and SRB51 rarely colonize maternal and fetal tissues of pregnant pronghorn and were not associated with fetal death. Oral delivery of either vaccine at this dose appears to be nonhazardous to pregnant pronghorn.
authors.affiliation: Louisiana State University, AgCenter and School of Veterinary Medicine, Baton Rouge, Louisiana 70803, USA. pelzer@agctr.lsu.edu
authors.forename: Philip H
authors.initials: PH
authors.lastname: Elzer
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Roffe
authors.forename: T
authors.initials: T
authors.lastname: Kreeger
authors.forename: J
authors.initials: J
authors.lastname: Edwards
authors.forename: D
authors.initials: D
authors.lastname: Davis
mesh_terms: D000034:Abortion, Veterinary / Q000209:etiology / Q000382:microbiology; D000284:Administration, Oral; D000818:Animals; D000835:Animals, Wild; D000866:Antelopes; D016164:Bison; D002004:Brucella Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D002003:Brucella abortus / Q000276:immunology* / Q000472:pathogenicity; D002006:Brucellosis / Q000517:prevention & control / Q000662:veterinary*; D003670:Deer; D004197:Disease Reservoirs / Q000662:veterinary; D005260:Female; D011247:Pregnancy; D014481:United States; D014611:Vaccination / Q000379:methods / Q000662:veterinary; D014774:Virulence
chemical_list: D002004:Brucella Vaccine