Characteristics of hyaluronate-hydroxyethyl acrylate blend gel and release of cationic amphiphilic solutes.
Hyaluronate-hydroxyethyl acrylate blend gel (HA-PHEA) were prepared to modify the brittleness of hyaluronate gel (HA) and the characteristics of HA-PHEA gel were compared with those of HA and polyhydroxyethyl acrylate (PHEA) gels. These gels were high in water content and transparent. HA-PHEA gel was improved in viscoelastic properties due to the elasticity and the high affinity with water of PHEA, and the drying-swelling cycles became reversible. The effective charge densities theta of the gels estimated from membrane potentials were -0.002, -0.008 and 0 mol dm(-3) for HA-PHEA, HA and PHEA gels. Effects of electro- static and nonelectrostatic interactions on absorptions and releases were studied using sodium benzoate (NaBA) as an anionic solute, and methylene blue (MB), chlorpromazine (CPHCl) and benzethonium chloride (BZTCl) as cationic solutes, in which CPHCl and BZTCl are cationic amphiphilic solutes. The releases of MB, CPHCl and BZTCl from HA-PHEA and HA gels were suppressed comparing with those of NaBA. By adding salts, the releases of MB and CPHCl were enhanced but those of BZTCl were suppressed due to enhancement of the intra- and intermicelle formation. In the releases of the cationic solutes from HA-PHEA gel, electrostatic and nonelectrostatic interactions with HA were found to play important roles. Behaviors of the releases from HA-PHEA gel were found to possess the features of HA gel.
Jin
Yu
Y
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan.
Yamanaka
Junpei
J
Sato
Shizuko
S
Miyata
Isamu
I
Yomota
Chikako
C
Yonese
Masakatsu
M
D000179:Acrylates / Q000737:chemistry* / Q000493:pharmacokinetics; D000464:Alginates / Q000737:chemistry / Q000493:pharmacokinetics; D002412:Cations; D005782:Gels; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D013501:Surface-Active Agents / Q000737:chemistry* / Q000493:pharmacokinetics
D000179:Acrylates; D000464:Alginates; D002412:Cations; D005782:Gels; D013501:Surface-Active Agents; C118495:hyaluronate alginate; D006820:Hyaluronic Acid