title: Ring chromosome 6 may represent a cytogenetic subgroup in benign thymoma.
abstract: Cytogenetic and fluorescence in situ hybridization analysis of a thymoma revealed the presence of an abnormal clone with a karyotype 46,XY,r(6)(p2?q35?).ish r(6)(p2?q35?)(WCP6+,dJ476O18-,dJ62I11-, PAC59C23+,PAC57H24-),der(21)t(6;21)(p25;q22)(dJ62I11+,cosC9a1-). Histologically, the tumor was encapsulated and classified as thymoma type AB (World Health Organization classification) or mixed thymoma (Muller-Hermelink classification), composed of well-formed lobules with sharp demarcation of both the spindly type A and lymphocyte-rich type B components. This finding, together with literature data, strongly suggests that terminal deletion of the short arm of chromosome 6 is a recurrent aberration in thymoma.
authors.affiliation: AZ. St. Jan, Department of Pathology, Ruddershove 10, 8000, Bruges, Belgium. ivo.vandenberghe@azbrugge.be
authors.forename: Ivo
authors.initials: I
authors.lastname: Van den Berghe
authors.forename: Maria
authors.initials: M
authors.lastname: Debiec-Rychter
authors.forename: Luc
authors.initials: L
authors.lastname: Proot
authors.forename: Anne
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: Paul
authors.initials: P
authors.lastname: Michielssen
mesh_terms: D000368:Aged; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D019656:Loss of Heterozygosity; D008297:Male; D009157:Myasthenia Gravis / Q000235:genetics*; D012303:Ring Chromosomes; D013896:Thoracic Diseases / Q000235:genetics / Q000473:pathology; D013945:Thymoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D013953:Thymus Neoplasms / Q000235:genetics* / Q000473:pathology