[Micronuclei induced by chronic inhalation of SO2 in mouse bone marrow cells].
In the chronic inhalation experiment of sulfur dioxide(SO2), micronuclei(MN) frequencies in the polychromatophilic erythroblasts(PCE) of mouse bone marrow and the frequencies of cells with MN were significantly increased in dose-dependent manner. There was a significant difference between the male and the female animals. The results also showed that SO2 inhibited urethone-induced MN formation. These results furtherly confirm that SO2 inhalation was a clastogenic and genotoxic agent to mammalian cells, and the combined effects of SO2 and other mutagens are complex.
Meng
Ziqiang
Z
Institute of Environmental and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006.
Ruan
Aidong
A
Sang
Nan
N
Zhang
Bo
B
Zhang
Jianbiao
J
D000280:Administration, Inhalation; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D012737:Sex Factors; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000633:toxicity*
D013458:Sulfur Dioxide