[Attenuation of chronic stress-induced hippocampal damages following physical exercise].
The long-term potentiation (LTP) in the hippocampal dentate gyrus and the plasma glucocorticoids level were observed in rats to study the effects of physical exercise on chronic stress-induced hippocampal damages. Eight-week spontaneous wheel running exercise could attenuate the suppression of LTP induced by 21-day restraint stress, and maintain the normal plasma glucocorticoids levels. It is suggested that long-term physical exercise may protect the hippocampus from stress-induced damages.
Ma
Qiang
Q
Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin, China. maqiangw@Hotmail.com
Wang
Jing
J
Liu
Hong-Tao
HT
Chao
Fu-Huan
FH
D000818:Animals; D003345:Corticosterone / Q000097:blood*; D006624:Hippocampus / Q000503:physiopathology*; D017774:Long-Term Potentiation; D008297:Male; D009043:Motor Activity; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood* / Q000503:physiopathology*
D003345:Corticosterone