Organ tolerance following cadaveric liver transplantation for chronic graft-versus-host disease after allogeneic bone marrow transplantation.
A paediatric patient was treated with orthotopic liver transplantation after he developed cirrhosis of the liver due to chronic graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation. His pre-existing chronic GVHD of the skin disappeared and immunosuppressive therapy could be gradually tapered and finally withdrawn 71 months after liver transplantation. Two and a half years after discontinuation of all immunosuppressive therapy, the patient is in excellent condition with neither signs of chronic GVHD nor rejection of the liver graft.
Urban
C H
CH
Department of Paediatrics and Adolescence Medicine, University of Graz, Austria.
Deutschmann
A
A
Kerbl
R
R
Lackner
H
H
Schwinger
W
W
Königsrainer
A
A
Margreiter
R
R
D000756:Anemia, Sideroblastic / Q000150:complications / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002102:Cadaver; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D008103:Liver Cirrhosis / Q000209:etiology / Q000628:therapy; D016031:Liver Transplantation; D008297:Male; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000009:adverse effects