title: [Association between aldosterone synthase gene polymorphism and hypertrophic cardiomyopathy].
abstract: OBJECTIVE
  To investigate the relationship between aldosterone synthase (CYP11B2) gene polymorphism and hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  Fifteen HCM patients and 18 healthy subjects were enrolled in this study. Peripheral blood samples were collected from these subjects to exact genome DNA. PCR and Hae III restriction endonuclease digestion were employed to study -344C/T polymorphism of CYP11B2 gene.
  
  
  RESULTS
  CYP11B2 gene showed a significant difference in CT genotype distribution in HCM groups as compared with that in the control groups (P<0.05).
  
  
  CONCLUSIONS
  CT genotype of CYP11B2 gene may be one of factors responsible for the pathogenesis of HCM in a proportion of patients.
authors.affiliation: Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. chenaha@21.cn.com
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Chen
authors.forename: Wen-Xiu
authors.initials: WX
authors.lastname: Zhang
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Li
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: Xue-Xian
authors.initials: XX
authors.lastname: Qian
authors.forename: Liu-Yang
authors.initials: LY
authors.lastname: Li
authors.forename: Jia-Zhen
authors.initials: JZ
authors.lastname: Sun
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000201:enzymology / Q000235:genetics*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D019405:Cytochrome P-450 CYP11B2