title: Studies on the biomimetic synthesis of SNF4435 C and D.
abstract: [reaction: see text] The biomimetic synthesis of the bicyclic core of the novel immunosuppresants SNF4435C and SNF4435D is reported. The core framework was efficiently generated from the all-trans tetraene precursor in one step and in good yield.
authors.affiliation: Chemical Crystallography, Oxford University, South Parks Road, Oxford OX1 3QR, U.K.
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
authors.forename: Jack E
authors.initials: JE
authors.lastname: Baldwin
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Marquez
authors.forename: Robert M
authors.initials: RM
authors.lastname: Adlington
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Cowley
mesh_terms: D018716:Molecular Mimicry; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D009574:Nitro Compounds; D011753:Pyrones; C435067:SNF 4435C; C435066:SNF 4435D