title: Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers.
abstract: Two injections of tetravalent (Groups A, C, Y and W-135) meningococcal polysaccharide vaccine conjugated to diphtheria were given to 30 toddlers at dosages of 1, 4 and 10 microg/ml polysaccharide of each serogroup. Reactogenicity was acceptable at all dosages. The 4-microg/ml dose appears to be immunologically optimal.
authors.affiliation: Center for Vaccine Development and Department of Pediatrics University of Maryland School of Medicine Baltimore, MD, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Rennels
authors.forename: James
authors.initials: J
authors.lastname: King
authors.forename: Robert
authors.initials: R
authors.lastname: Ryall
authors.forename: Susan
authors.initials: S
authors.lastname: Manoff
authors.forename: Thomas
authors.initials: T
authors.lastname: Papa
authors.forename: Andrea
authors.initials: A
authors.lastname: Weddle
authors.forename: James
authors.initials: J
authors.lastname: Froeschle
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007115:Immunization Schedule; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage*; D011135:Polysaccharides, Bacterial; D012449:Safety; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods*; D018074:Vaccines, Conjugate
chemical_list: D000942:Antigens, Bacterial; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate