title: Novel nucleotide phosphonate analogues with potent antitumor activity.
abstract: We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC(50) values in the microM range. The synthesis as well as structure-activity relationship are described.
authors.affiliation: Shire BioChem Inc., 275 Armand-Frappier Blvd., Laval, Québec, Canada H7V 4A7. mbubenik@ca.shire.com
authors.forename: Monica
authors.initials: M
authors.lastname: Bubenik
authors.forename: Rabindra
authors.initials: R
authors.lastname: Rej
authors.forename: Nghe
authors.initials: N
authors.lastname: Nguyen-Ba
authors.forename: Giorgio
authors.initials: G
authors.lastname: Attardo
authors.forename: France
authors.initials: F
authors.lastname: Ouellet
authors.forename: Laval
authors.initials: L
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D009711:Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D009711:Nucleotides; D063065:Organophosphonates; C018674:tetrahydrofuran; D013936:Thymidine