The effect of prostaglandin E(2) (PGE(2)) and long-chain polyunsaturated fatty acids (LC PUFA) on bone formation in piglets: a model for bone growth in nutritional investigation.
This research investigates the effects of exogenous prostaglandin E(2) (PGE(2)) treatment and arachidonic acid supplementation on the rate of growth in modelling bone of piglets. The piglet is a good model for the study of infant nutrition and bone growth. PGE(2) and long-chain polyunsaturated fatty acid (LC PUFA) supplementation, alone and in combination, are shown to have little or no effect on cortical bone thickness. Though exogenous PGE(2) supplementation and LC PUFA supplementation may both be effective in promoting bone growth and mass in adults, they do not appear to have the same positive effect on bone growth in infancy over a short term. A dynamic model for bone growth in piglets is proposed here for the first time. This research adds to our knowledge of the relationship between the dynamic histology of bone, the rate of osteogenesis, and the link between nutrition and bone growth.
Burke
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A
Department of Anthropology, University of Manitoba, Winnipeg, Manitoba, Canada.
Weiler
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H
D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D019587:Dietary Supplements; D015232:Dinoprostone / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D009747:Nutritional Physiological Phenomena / Q000502:physiology; D010012:Osteogenesis / Q000187:drug effects*; D013552:Swine; D013977:Tibia / Q000033:anatomy & histology / Q000187:drug effects
D005231:Fatty Acids, Unsaturated; D015232:Dinoprostone