Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue.
In this study, we examined the effect of nimesulide and ranitidine on the indomethacin- and ibuprofen-induced ulcer. In addition, we investigated whether there was a direct chemical interaction of nimesulide and ranitidine with indomethacin, and also whether nimesulide and ranitidine neutralized the gastric acid in vitro. Our studies showed that nimesulide (100, 300, 500 mg/kg) prevented the indomethacin-induced gastric ulcers completely. Ranitidine at a dose of 150 mg/kg reduced the mean ulcer area to 2.5 +/- 0.76 mm2 in the indomethacin-treated and to 2.0 +/- 0.81 mm2 in ibuprofen-treated rats. The mean ulcer areas in rats given only indomethacin and only ibuprofen were 20.3 +/- 1.58 mm2 and 9.5 +/- 1.43 mm2, respectively. There were no chemical reactions between nimesulide and indomethacin or ranitidine and indomethacin in vitro. Nimesulide and ranitidine did not neutralize the gastric acid in vitro.
Süleyman
Halis
H
Atatürk University, Medical Faculty, Department of Pharmacology, Erzurum, Turkey. suleyman@atauni.edu.tr
Altinkaynak
Konca
K
Göçer
Fatma
F
Maraş
Ahmet
A
Akçay
Fatih
F
Onuk
M Derya
MD
Gepdiremen
Akçahan
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000633:toxicity; D007052:Ibuprofen / Q000493:pharmacokinetics / Q000633:toxicity*; D007213:Indomethacin / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D013449:Sulfonamides / Q000493:pharmacokinetics / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C012655:nimesulide; D007052:Ibuprofen; D007213:Indomethacin