title: Distribution of the CCR5 gene 32-basepair deletion in 11 Chinese populations.
abstract: A mutant allele of the chemokine receptor gene CCR5 bearing a 32-basepair deletion (delta 32CCR5) could increase the resistance to HIV-1 infection or delayed progression to AIDS. The frequency of this mutation is higher in Europeans than in Asians. To investigate the distribution of this polymorphism in China, 715 individuals from 11 Chinese populations were screened by PCR, including the Han and 10 other ethnic groups. The delta 32CCR5 gene was found in 16 individuals from 5 ethnic groups. All of them were heterozygous. The frequency of the mutant alleles of delta 32CCR5 is low in China and reflects (or might reflect) ancestral gene flow from Europe to Chinese ethnic groups and recent intermarriage within the ethnic groups.
authors.affiliation: Department of Medical Genetics, Harbin Medical University, Harbin, China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Zhang
authors.forename: Songbin
authors.initials: S
authors.lastname: Fu
authors.forename: Yali
authors.initials: Y
authors.lastname: Xue
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Huang
authors.forename: Baiqiu
authors.initials: B
authors.lastname: Wang
authors.forename: An
authors.initials: A
authors.lastname: Liu
authors.forename: Linlin
authors.initials: L
authors.lastname: Ma
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Rongqian
authors.initials: R
authors.lastname: Shi
authors.forename: Fuqu
authors.initials: F
authors.lastname: Lv
authors.forename: Zhongcheng
authors.initials: Z
authors.lastname: Shi
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wenhong
authors.initials: W
authors.lastname: Cheng
authors.forename: Qionghua
authors.initials: Q
authors.lastname: Ai
authors.forename: Fang
authors.initials: F
authors.lastname: Xu
authors.forename: Chengbin
authors.initials: C
authors.lastname: Huang
authors.forename: Baibin
authors.initials: B
authors.lastname: Chen
authors.forename: Xianghua
authors.initials: X
authors.lastname: Kang
authors.forename: Yanyang
authors.initials: Y
authors.lastname: Sun
authors.forename: Guiyin
authors.initials: G
authors.lastname: Zhang
authors.forename: Pu
authors.initials: P
authors.lastname: Li
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics; D000483:Alleles; D044466:Asian People; D020029:Base Pairing / Q000235:genetics*; D002681:China; D002872:Chromosome Deletion; D018450:Disease Progression; D005787:Gene Frequency / Q000235:genetics*; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005828:Genetics, Population; D015658:HIV Infections / Q000235:genetics; D015497:HIV-1; D006801:Humans; D009154:Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D019713:Receptors, CCR5