Multiparameter selection of Helicobacter pylori antigens identifies two novel antigens with high protective efficacy.
A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other organisms (HP0231 and HP0410) were overexpressed and purified with high yields. Both confer protective immunity in the mouse Helicobacter infection model.
Sabarth
N
N
Department of Molecular Biology, Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany.
Hurwitz
R
R
Meyer
T F
TF
Bumann
D
D
D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines