title: Plasma cell granuloma in cyclosporine-induced gingival overgrowth: a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-gamma1.
abstract: We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C- gamma 1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.
authors.affiliation: Department of Pathology, Medical School, University of Ulsan, Ulsan, Korea.
authors.forename: Sung Sook
authors.initials: SS
authors.lastname: Kim
authors.forename: Daewoon
authors.initials: D
authors.lastname: Eom
authors.forename: Jooryung
authors.initials: J
authors.lastname: Huh
authors.forename: Iel-yong
authors.initials: IY
authors.lastname: Sung
authors.forename: Inpyo
authors.initials: I
authors.lastname: Choi
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Ryu
authors.forename: Pann Ghill
authors.initials: PG
authors.lastname: Suh
authors.forename: Sung-Min
authors.initials: SM
authors.lastname: Chung
mesh_terms: D016572:Cyclosporine / Q000009:adverse effects; D005260:Female; D005882:Gingival Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D006104:Granuloma, Plasma Cell / Q000139:chemically induced* / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015850:Interleukin-6 / Q000378:metabolism; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D051966:Phospholipase C gamma; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; D015850:Interleukin-6; D016572:Cyclosporine; D010738:Type C Phospholipases; D051966:Phospholipase C gamma