siRNA. A guide for RNA silencing.
RNAi is routinely used to eliminate gene activity for experimental purposes. However, the precise molecular mechanism of RNAi is unknown. Recent papers partially illuminate this mechanism in human cells, advancing the potential application of RNAi toward the treatment of human disease.
Ramaswamy
Gopalakrishna
G
Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.
Slack
Frank J
FJ
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing / Q000502:physiology*; D006801:Humans; D016133:Polymerase Chain Reaction; D012323:RNA Processing, Post-Transcriptional; D012330:RNA, Double-Stranded / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology
D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D034741:RNA, Small Interfering