title: Creating an online dictionary of abbreviations from MEDLINE.
abstract: OBJECTIVE
  The growth of the biomedical literature presents special challenges for both human readers and automatic algorithms. One such challenge derives from the common and uncontrolled use of abbreviations in the literature. Each additional abbreviation increases the effective size of the vocabulary for a field. Therefore, to create an automatically generated and maintained lexicon of abbreviations, we have developed an algorithm to match abbreviations in text with their expansions.
  
  
  METHODS
  Our method uses a statistical learning algorithm, logistic regression, to score abbreviation expansions based on their resemblance to a training set of human-annotated abbreviations. We applied it to Medstract, a corpus of MEDLINE abstracts in which abbreviations and their expansions have been manually annotated. We then ran the algorithm on all abstracts in MEDLINE, creating a dictionary of biomedical abbreviations. To test the coverage of the database, we used an independently created list of abbreviations from the China Medical Tribune.
  
  
  METHODS
  We measured the recall and precision of the algorithm in identifying abbreviations from the Medstract corpus. We also measured the recall when searching for abbreviations from the China Medical Tribune against the database.
  
  
  RESULTS
  On the Medstract corpus, our algorithm achieves up to 83% recall at 80% precision. Applying the algorithm to all of MEDLINE yielded a database of 781,632 high-scoring abbreviations. Of all the abbreviations in the list from the China Medical Tribune, 88% were in the database.
  
  
  CONCLUSIONS
  We have developed an algorithm to identify abbreviations from text. We are making this available as a public abbreviation server at \url[http://abbreviation.stanford.edu/].
authors.affiliation: Department of Genetics, Stanford Medical Informatics, Stanford, California 94305, USA.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Chang
authors.forename: Hinrich
authors.initials: H
authors.lastname: Schütze
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
mesh_terms: D000004:Abbreviations as Topic; D000043:Abstracting and Indexing / Q000639:trends; D000465:Algorithms; D004014:Dictionaries as Topic; D016015:Logistic Models; D016239:MEDLINE / Q000639:trends