BAG-1 expression and function in human cancer.
BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.
Cutress
R I
RI
Cancer Research UK Oncology Unit, Cancer Sciences Division, Mail Point 824, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. R.Cutress@soton.ac.uk
Townsend
P A
PA
Brimmell
M
M
Bateman
A C
AC
Hague
A
A
Packham
G
G
D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002352:Carrier Proteins / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division; D002986:Clinical Trials as Topic; D004268:DNA-Binding Proteins; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000502:physiology
C091732:BCL2-associated athanogene 1 protein; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors