title: Molluscicidal and radical scavenging activity of quinones from the root bark of Caryopteris x clandonensis.
abstract: In the search for new molluscicidal natural products, the activity of the chloroform extract of the root barks of Caryopteris x clandonensis was tested. The LC(100) was <5 ppm. The fractionation and purification of the extract afforded 15-deoxyfuerstione, fuerstione and alpha-caryopterone as the main compounds. These compounds were tested against the snail Bulinus truncatus, an intermediate host snail of a schistosomiasis parasite and showed strong molluscicidal activity with LC(100)<4 ppm. In addition, they were found to have potent radical scavenging properties on superoxide radical.
authors.affiliation: Laboratoire Pharmacophores Redox, Phytochimie et Radiobiologie, Faculté des Sciences Pharmaceutiques, 35 Chemin des Maraîchers, F-31062 Toulouse Cedex 04, France. shannedouche@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Hannedouche
authors.forename: J P
authors.initials: JP
authors.lastname: Souchard
authors.forename: I
authors.initials: I
authors.lastname: Jacquemond-Collet
authors.forename: C
authors.initials: C
authors.lastname: Moulis
mesh_terms: D000818:Animals; D016166:Free Radical Scavengers / Q000737:chemistry*; D019686:Lamiaceae; D007928:Lethal Dose 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects*
chemical_list: D016166:Free Radical Scavengers; D010936:Plant Extracts; D011809:Quinones