A pilot study of oral fleroxacin once daily compared with conventional therapy in patients with pyogenic liver abscess.
The object of this open-label, randomized, comparative study was to evaluate the efficacy and safety of fleroxacin versus conventional therapy (cefazolin plus gentamicin/cephalexin) in the treatment of patients with bacterial liver abscess. Thirty-one adult patients (26 men and 5 women) received fleroxacin 400 mg orally once daily for 3 weeks, and 30 adult patients (21 men and 9 women) received conventional therapy for 3 to 4 weeks. Patients was assessed on day 3 of treatment, thereafter every week during treatment, and at 7 to 14 days (compulsory follow-up) after treatment for assessment of bacteriologic, clinical, and safety parameters. A total of 20 patients in the fleroxacin group and 22 patients in the conventional therapy group were evaluated. Klebsiella pneumoniae was the predominant pathogen isolated in all evaluable cases. Bacteriologic cure was achieved in 14 (70%) of 20 patients on fleroxacin therapy compared with 18 (81.8%) of 22 patients on conventional therapy (p=0.48). Clinical cure was achieved in 12 (60%) and 18 (81.8%) patients, and improvement in 2 (10%) and 1 (4.5%) patients in the fleroxacin and conventional therapy group, respectively. Most of adverse effects were of mild intensity. Oral fleroxacin once-daily administration is an effective, alternative treatment of bacterial liver abscess.
Chen
Yan-Wan
YW
Section of Infectious Diseases, Kaohsiung Veterans General Hospital, Taiwan, ROC.
Chen
Yao-Shen
YS
Lee
Susan Shin-jung
SS
Yen
Muh-Yong
MY
Wann
Shue-Ren
SR
Lin
Hsi-Hsun
HH
Huang
Wen-Kuei
WK
Liu
Yung-Ching
YC
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D004334:Drug Administration Schedule; D005260:Female; D016576:Fleroxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008100:Liver Abscess / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D010865:Pilot Projects; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D016576:Fleroxacin