Recognition of mucin components by Pseudomonas aeruginosa.
Pseudomonas aeruginosa remains one of the most important bacterial pathogens in lung diseases and especially in Cystic fibrosis. This unusual predilection is best explained by the existence of defects in host defense mechanisms as resulting from the genetic lesion and the presence of a specific colonization niche within the lungs. The niche has been identified as the mucus layer wherein mucin glycoproteins provide a substrate for binding and allows the persistence of this organism in this milieu by a number of possible mechanisms. While this organism is capable of binding to non CF mucins, it is perhaps a combination of factors e.g. increased binding and decreased mucociliary clearance that is responsible for this marked state of colonization in CF. The organism uses chiefly proteins of its flagellar apparatus to initiate this binding and recognizes a variety of oligosaccharides that have been identified in mucins. Among these are both, neutral oligosaccharides and several forms of acidic oligosaccharides derived from the Lewis antigens. There are more than likely a larger repertoire of receptors than those identified and certainly more adhesins present than those currently known. However, the information gathered to date provides an excellent example of the specificity of bacterial interactions with mucins that will certainly be expanded as we study more pulmonary pathogens.
Ramphal
R
R
Department of Medicine, University of Florida, Gainesville, FL 32610, USA. ramphr@medmac.ufl.edu
Arora
S K
SK
D001422:Bacterial Adhesion / Q000502:physiology*; D001426:Bacterial Proteins / Q000378:metabolism; D002240:Carbohydrate Sequence; D003550:Cystic Fibrosis / Q000276:immunology / Q000382:microbiology; D005408:Flagellin / Q000378:metabolism; D006001:Glycoconjugates / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism* / Q000502:physiology
D001426:Bacterial Proteins; D006001:Glycoconjugates; D009077:Mucins; D009844:Oligosaccharides; D005408:Flagellin