Polyurethane-covered dacron mesh versus polytetrafluoroethylene DualMesh for intraperitoneal hernia repair in rats.
OBJECTIVE
Abdominal hernia repair using the intraperitoneal implantation of a prosthesis requires mesh with impervious properties, such as expanded polytetrafluoroethylene (ePTFE). A newly developed polyurethane-covered polyester mesh with impervious properties has recently been introduced as a less expensive alternative to PTFE, and we compare these materials herein.


METHODS
The adhesion formation and stability of intraperitoneal abdominal hernia repairs with DualMesh (macroporous ePTFE mesh with a microporous component) and PolyesterComposite (the newly developed polyurethane-covered Dacron mesh) were compared in a rat model. Forty rats were randomly divided into two groups; ten animals from each group were killed after 14 days, and the other ten after 90 days.


RESULTS
The number and intensity of adhesions were comparable in the PolyesterComposite and PTFE groups. Loose adhesions were seen in 13 animals and appeared only selectively at the fixation sutures. Both PolyesterComposite and PTFE induced the formation of a smooth neoperitoneum on the intraperitoneal surface and showed a complete ingrowing of the prosthesis in the surrounding tissue. There were no significant differences between the prostheses in terms of clinical herniation pressure and hydroxyproline concentration.


CONCLUSIONS
PolyesterComposite and PTFE are both suitable prostheses for intrapertoneal implantation, but PolyesterComposite is less expensive, which is an important advantage for clinical use.
Zieren
Jürgen
J
Department of General, Visceral, Vascular, and Thoracic Surgery, Charité, Campus Mitte, Humboldt University of Berlin, Schumannstrasse 20/21, D-10117 Berlin, Germany.
Paul
Marco
M
Osei-Agyemang
Thomas
T
Maecker
Folkert
F
Müller
Jochen M
JM
D000818:Animals; D019094:Dental Prosthesis, Implant-Supported; D006555:Hernia, Ventral / Q000601:surgery*; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh
D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene