Renotropic role and therapeutic potential of HGF in the kidney.
Hepatocyte growth factor (HGF) has mitogenic, morphogenic and anti-apoptotic activities on renal epithelial cells, and is a potential renotropin for renal regeneration. In chronic renal failure/fibrosis, HGF in the kidney declines in a manner reciprocal to the increase in transforming growth factor-beta (TGF-beta). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis, while HGF administration leads to remarkable attenuation, thus indicating the importance of the balance between HGF and TGF-beta in the pathogenesis and therapy of chronic renal failure. HGF is strongly considered as potential treatment for acute and chronic renal failure.
Matsumoto
Kunio
K
Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Nakamura
Toshikazu
T
D000818:Animals; D017228:Hepatocyte Growth Factor / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008934:Mitogens / Q000378:metabolism; D051437:Renal Insufficiency / Q000188:drug therapy*; D016212:Transforming Growth Factor beta / Q000378:metabolism
D008934:Mitogens; D016212:Transforming Growth Factor beta; D017228:Hepatocyte Growth Factor