title: Synthesis of series of 1- and 3-differently substituted xanthines from imidazoles.
abstract: A new and general method is described for the synthesis, in three steps and in good overall yields, of tetrasubstituted xanthines from an easily prepared imidazole precursor. The method is especially useful for the preparation in standardized conditions of series of xanthines combining a broad variety of primary or secondary alkyl, benzyl or aryl groups at N1 and of alkyl or arylmethyl groups at N3, that are not readily available by other methods.
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, Spain.
authors.forename: Antonio Rodríguez
authors.initials: AR
authors.lastname: Hergueta
authors.forename: María José
authors.initials: MJ
authors.lastname: Figueira
authors.forename: Carmen
authors.initials: C
authors.lastname: López
authors.forename: Olga
authors.initials: O
authors.lastname: Caamaño
authors.forename: Franco
authors.initials: F
authors.lastname: Fernández
authors.forename: José Enrique
authors.initials: JE
authors.lastname: Rodríguez-Borges
mesh_terms: D007093:Imidazoles / Q000737:chemistry*; D014970:Xanthines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007093:Imidazoles; D014970:Xanthines