title: Sunset glow fundus in Vogt-Koyanagi-Harada disease with or without chronic ocular inflammation.
abstract: BACKGROUND
  Sunset glow fundus is considered an important ocular finding for diagnosing and understanding the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. In this study, we investigated the association between the incidence of chronic ocular inflammation in VKH disease and the appearance of sunset glow fundus.
  
  
  METHODS
  The study was a retrospective noncomparative interventional case series. Eighty patients with VKH disease treated with high-dose corticosteroid therapy from initial onset were included in the study. We compared the incidence of sunset glow fundus between patients with VKH disease with chronic ocular inflammation lasting more than 6 months and those without chronic ocular inflammation.
  
  
  RESULTS
  Chronic ocular inflammation was seen in 14 of 80 patients (17.5%). The presence of severe anterior uveitis were significantly more frequent in the chronic group. Forty-one patients (62%) without chronic ocular inflammation showed sunset glow fundus, while 13 patients (93%) with chronic ocular inflammation developed sunset glow fundus. Duration from disease onset to appearance of sunset glow fundus was significantly shorter in patients with than in patients without chronic inflammation.
  
  
  CONCLUSIONS
  There is a significant association between the incidence of chronic ocular inflammation lasting more than 6 months and the appearance of sunset glow fundus. In addition, more severe disease at onset might be associated with chronic ocular inflammation in VKH disease.
authors.affiliation: Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA. keino@vision.eri.harvard.edu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Keino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Usui
mesh_terms: D000328:Adult; D002908:Chronic Disease; D009877:Endophthalmitis / Q000150:complications*; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000150:complications; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000473:pathology*