A novel three-component reaction for the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinolines via 1,4-dipolar cycloaddition.
[reaction: see text] The 1,4-dipole derived from isoquinoline and DMAD has been shown to react readily with N-tosylimines resulting in the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinoline derivatives.
Nair
Vijay
V
Organic Chemistry Division, Regional Research Laboratory, CSIR, Trivandrum 695 019, India. gvn@csrrltrd.ren.nic.in
Sreekanth
A R
AR
Abhilash
N
N
Bhadbhade
Mohan M
MM
Gonnade
Rajesh C
RC