title: Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1.
abstract: Obstructive sleep apnea syndrome (OSAS) is one of the most important risk factors of cardiovascular disorders. In the treatment of OSAS, nasal continuous positive airway pressure (nCPAP) has been widely used and found to be effective. In the present study, we hypothesized that the hypoxic stress caused by obstructive sleep apnea would increase circulating intercellular adhesion molecule-1 (ICAM-1), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1) in untreated OSAS patients compared with an age-matched control group. In addition, we hypothesized that nCPAP may decrease OSAS-induced hypoxic stress and mediators. To examine these hypotheses, we measured circulating ICAM-1 and IL-8 before and after nCPAP therapy in OSAS patients. We observed that nCPAP decreased apnea, desaturation, and the circulating ICAM-1 and IL-8 levels in OSAS patients. The circulating levels of ICAM-1, IL-8, and MCP-1 in untreated OSAS patients were significantly greater than those in the controls. These observations suggest that nCPAP therapy could reduce OSAS-induced hypoxia and generation of inflammatory mediators. Treatment of OSAS using nCPAP can be, therefore, a potential approach to decrease risk of the progression of OSAS-associated disorders.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan.
authors.forename: Eijiro
authors.initials: E
authors.lastname: Ohga
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Tomita
authors.forename: Hiroo
authors.initials: H
authors.lastname: Wada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Takahide
authors.initials: T
authors.lastname: Nagase
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Ouchi
mesh_terms: D018932:Chemokine CCL2 / Q000097:blood*; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000209:etiology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000628:therapy; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology
chemical_list: D018932:Chemokine CCL2; D016209:Interleukin-8; D018799:Intercellular Adhesion Molecule-1