Applicability of radiosurgery with heavy ion beams to inactivate specific organs in living organisms.
It was the aim of the study to test the applicability of radiosurgery in inactivating a specific organ through local irradiation with heavy ion beams. Silkworms were exposed to whole-body or local irradiation with carbon ion beams ((12)C(5+), 18.3 MeV/u, range=1.1 mm). After irradiation at the wandering stage, no significant differences were observed regarding either survival or cocoon quality between locally irradiated larvae and controls. Only localized effects were seen, such as the deletion of wings and functional disorders of the reproduction primordium, depending on both irradiation dose and site. This observation was not true for whole-body irradiated larvae. After local irradiation of the hemopoietic organs at the 4th instar premolting stage, the hemocyte densities were clearly reduced and the hemopoietic organ capacity was disrupted. The change in hemocyte densities was accompanied by changes of hemolymph components. These results show that radiosurgery utilizing heavy ion beams can destroy a specific organ or tissue in a living organism.
Tu
Zhen-Li
ZL
Department of Radiation Research for Environment and Resources, Takasaki Radiation Chemistry Research Establishment, Japan. tu514@yahoo.co.jp
Kobayashi
Yasuhiko
Y
Kiguchi
Kenji
K
Watanabe
Hiroshi
H
D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D012831:Bombyx / Q000166:cytology / Q000502:physiology / Q000528:radiation effects*; D002250:Carbon Radioisotopes / Q000008:administration & dosage*; D004307:Dose-Response Relationship, Radiation; D004531:Eggs / Q000528:radiation effects; D005260:Female; D020450:Heavy Ions; D006410:Hematopoiesis / Q000528:radiation effects; D006413:Hematopoietic System / Q000528:radiation effects; D006434:Hemocytes / Q000528:radiation effects; D007814:Larva / Q000166:cytology / Q000502:physiology / Q000528:radiation effects; D009154:Mutation / Q000528:radiation effects; D009928:Organ Specificity; D010053:Ovary / Q000528:radiation effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000401:mortality; D011836:Radiation Tolerance; D016634:Radiosurgery; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D002250:Carbon Radioisotopes