[Role of Rho/Rho-kinase pathway in angiotensin II signaling].
Angiotensin II plays an important role for the development of cardiovascular diseases. Recent results have indicated an involvement of Rho/Rho-kinase pathway in the signaling of angiotensin II type 1 receptor. Inhibition of Rho or Rho-kinase inhibited angiotensin II-induced hypertrophy of vascular smooth muscle cells and expression of monocyte chemoattractant protein-1 and plasminogen activator inhibitor protein-1. HMGCoA reductase inhibitor-induced downregulation of AT1-R was due to inhibition of Rho pathway. Rho is known to activate transcription factors such as NF-kappa B and serum response factor. However, molecular mechanisms by which AT1-R activates Rho or Rho activates these transcription factors are largely unknown. Further study is necessary to delineate the molecular pathway of angiotensin II-induced activation of Rho/Rho-kinase pathway.
Ichiki
Toshihiro
T
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences.
D000209:Acute-Phase Proteins / Q000502:physiology*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D054460:rho-Associated Kinases
D000209:Acute-Phase Proteins; D047908:Intracellular Signaling Peptides and Proteins; C010781:acute-phase protein rho; D000804:Angiotensin II; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases