title: Asymmetrical closure of epiphyses in a patient with sickle cell anemia.
abstract: There is a high incidence of delayed sexual development and short stature during childhood in children with sickle cell anemia (SCA). We report a 15 year-old male with SCA who presented with significant short stature after a near death event (involving seizures and prolonged hypoxia). His evaluation showed growth hormone (GH) deficiency with low insulin-like growth factor-I (IGF-I), low IGF binding protein-3, and low GH response to stimulation. He was started on GH replacement with poor response in height gain although with normal response in terms of elongation of his arm span. Further studies showed premature closure of the epiphyses of the femora and tibiae bilaterally. This report demonstrates that children with SCA may present with growth failure not only due to nutritional and GH abnormalities but also due to abnormal growth plates, probably due to local anoxic events. Children with SCA should always have their arm span measured carefully.
authors.affiliation: Division of Endocrinology, Duke University Medical Center, Durham, NC, USA. paulosolberg@netscape.net
authors.forename: Paulo F
authors.initials: PF
authors.lastname: Collett-Solberg
authors.forename: Russell E
authors.initials: RE
authors.lastname: Ware
authors.forename: Sara M
authors.initials: SM
authors.lastname: O'Hara
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000000981:diagnostic imaging; D001132:Arm / Q000033:anatomy & histology; D004838:Epiphyses / Q000254:growth & development*; D006130:Growth Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D007717:Knee / Q000254:growth & development; D008297:Male; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate
chemical_list: D019382:Human Growth Hormone; D013669:Technetium Tc 99m Medronate