Correlation between angiotensin II type 1 receptor gene polymorphism and type 2 diabetes mellitus complicated by hypertension.
OBJECTIVE
To elucidate the correlation between angiotensin II type 1 receptor (AT1R) gene polymorphism and type 2 diabetes mellitus (T2DM) complicated by hypertension.


METHODS
AT1R gene polymorphism was determined by PCR in 132 T2DM patients complicated by hypertension and 107 normotensive T2DM patients.


RESULTS
The frequencies of AA and AC genotypes in the 2 groups were 88.79% vs 96.97% and 11.21% vs 3.03% respectively, and those for A and C allele were 94.39% vs 98.48% and 5.61% vs 1.51%, showing significant difference between the 2 groups (P<0.05). It was suggested that AT1R gene polymorphism was associated with T2DM complicated by hypertension, and the patients had significantly prolonged courses of DM when complicated by hypertension. Normotensive DM patients did not differ from DM patients with only elevated diastolic blood pressure in terms of AT1R-A1166-C gene polymorphism, but showed significant difference from DM patients with elevated systolic blood pressure.


CONCLUSIONS
AT1R gene contributed to T2DM complicated by hypertension, but is only associated with cases of elevated systolic blood pressure.
Xue
Yao-Ming
YM
Department of Endocrinology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Zhou
Lin
L
Luo
Ren
R
D000328:Adult; D000368:Aged; D000483:Alleles; D001794:Blood Pressure / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000235:genetics*
D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin