Differences in rate and variability of intracellular growth of a panel of Mycobacterium tuberculosis clinical isolates within a human monocyte model.
Significant differences were observed in the capacities of Mycobacterium tuberculosis clinical isolates to grow within human monocytes. Genotyping indicated that the four most rapidly growing isolates were members of the Beijing strain family. M. tuberculosis strain H37Rv provided more reproducible infection than the clinical isolates or M. tuberculosis Erdman.
Li
Qing
Q
Department of Medicine, Case Western Reserve University School of Medicine, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
Whalen
Christopher C
CC
Albert
Jeffrey M
JM
Larkin
Rhonda
R
Zukowski
Lynn
L
Cave
M Donald
MD
Silver
Richard F
RF
D024881:Drug Resistance, Bacterial; D006801:Humans; D009000:Monocytes / Q000382:microbiology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development*; D015203:Reproducibility of Results