Effect of enucleation on the expression of c-Fos protein in the supraoptic nucleus of the Japanese monkey (Macaca fuscata).
The aim of this study was to examine the effects of one eye enucleation on the expression of c-Fos protein in the hypothalamus of the Japanese monkey (Macaca fuscata). Compared with an intact monkey, significantly increased numbers of c-Fos positive neurons were observed in the supraoptic nuclei on both sides at 1 h after eye enucleation. This maximal c-Fos expression then started to decrease at 3 h after eye enucleation. Furthermore, by a dual-labeled immunocytochemical study, the c-Fos immunoreactivity was found mainly in the vasopressinergic but not in the oxytocinergic neurons within the supraoptic nucleus. These results suggest that vasopressinergic but not oxytocinergic neurons within the supraoptic nucleus may have critical roles in the stimulation of this nucleus in response to eye enucleation.
Kazi
Jamil Ahsan
JA
Department of Anatomy, Faculty of Medicine, Kagoshima University, 35-1, Sakuragaoka 8 chome, Kagoshima-shi, Kagoshima 890-8520, Japan.
Mori
Shiro
S
Gao
Hong-Zhi
HZ
Uehara
Fumiyuki
F
Nakagawa
Shiro
S
D000818:Animals; D015353:Eye Enucleation / Q000379:methods; D005260:Female; D008251:Macaca; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D013495:Supraoptic Nucleus / Q000737:chemistry / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos