title: Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America.
abstract: PCR-SSOP identification procedures for IL-2, IL-6, IL-10, TNF-alpha and TNF-beta cytokine polymorphisms have been developed. Application of the procedures to a range of diverse geographically distributed populations has identified ethnic differences within the groups studied. Five populations were investigated, Northern Ireland, South African Zulu, Omani, Singapore Chinese and Mexican Mestizos.
authors.affiliation: Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland.
authors.forename: Ashley
authors.initials: A
authors.lastname: Meenagh
authors.forename: Fionnuala
authors.initials: F
authors.lastname: Williams
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Chris
authors.initials: C
authors.lastname: Patterson
authors.forename: Clara
authors.initials: C
authors.lastname: Gorodezky
authors.forename: Mike
authors.initials: M
authors.lastname: Hammond
authors.forename: William A
authors.initials: WA
authors.lastname: Leheny
authors.forename: Derek
authors.initials: D
authors.lastname: Middleton
mesh_terms: D000349:Africa; D000483:Alleles; D001208:Asia; D016207:Cytokines / Q000235:genetics*; D005060:Europe; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D008233:Lymphotoxin-alpha / Q000235:genetics; D008877:Middle East; D011110:Polymorphism, Genetic; D013020:South America; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D015850:Interleukin-6; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10