Medico-genetic and cytogenetic investigation in family with high predisposition to diffuse intestine polyposis.
We revealed a family consisting of 25 persons which displayed high predisposition to malignant diseases of the gastrointestinal tract (GIT): rectal cancer (RC) was diagnosed in 2 patients, large intestine malignant polyposis (LIMP) in 1 patient, large intestine diffuse polyposis (LIDP) in 3 and uterus fibromyoma in 1 patient. Six members of the family were examined cytogenetically with the methaphase method on blood lymphocytes following G-banding of chromosomes. In 2 patients with LIDP was detected 8.7 and 16.7% of hyperaneuploid cells, respectively, and 20% of cells with double minute chromosomes (DMS) were detected in 1 LIDP patient. We suppose, that LIDP development in members of the family is related to the significant increase of proportion of hyperaneuploid and DMS-containing cells.
Monakhov
A S
AS
N.N.Petrov Research Institute of Oncology, St. Petersburg, Russia. monakhov@canfem.spb.su
Guljaev
A V
AV
Aksenov
A V
AV
Hanson
K P
KP
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D003582:Cytogenetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics*; D007889:Leiomyoma / Q000235:genetics; D008214:Lymphocytes / Q000097:blood; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012004:Rectal Neoplasms / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics