title: [Olanzapine improves chorea in patients with Huntington's disease].
abstract: BACKGROUND
  The main treatment for choreatic movements associated to Huntington s disease are the neuroleptic drugs, however, its use causes long term troubles.
  
  
  METHODS
  We describe two patients with a predominantly choreic Huntington s disease, who experience improvement of choreatic movements after introduction of olanzapine to their treatment, being this drug well tolerated.
  
  
  CONCLUSIONS
  The improvement of chorea suggests that olanzapine has a dopaminergic D2 receptors blocking action.
authors.affiliation: Servicio de Nurología, Hospital Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España. fjimenezj@meditex.es
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: M
authors.initials: M
authors.lastname: de Toledo
authors.forename: I
authors.initials: I
authors.lastname: Puertas
authors.forename: M
authors.initials: M
authors.lastname: Barón
authors.forename: M
authors.initials: M
authors.lastname: Zurdo
authors.forename: B
authors.initials: B
authors.lastname: Barcenilla
mesh_terms: D001569:Benzodiazepines; D002819:Chorea / Q000188:drug therapy* / Q000209:etiology; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D065127:Dopamine D2 Receptor Antagonists; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D001569:Benzodiazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D000077152:Olanzapine; D010890:Pirenzepine; D017367:Selective Serotonin Reuptake Inhibitors