[Natural autoantibodies against MP65 and ACBP14/18 and ontogenic formation of rat nervous system].
It was demonstrated that passive immunization of pregnant female rats against MP65 and ACBP14/18 proteins leads to stable changes in offspring behavior (deviations in acquisition of active avoidance in a shuttle-box and changes in the open-field behavior). Immunomorphological data about localization of MP65 and ACBP14/18 proteins in brain slices of adult rats and rat embryos are presented. The obtained results are discussed in terms of the influence of maternal humoral immunity on the formation of fetal nervous system during intrauterine development.
Vakhrushina
S V
SV
Medico-Ecological Foundation Chernobyl-Test, Moscow.
Anan'eva
E P
EP
Shinkarev
A S
AS
D000818:Animals; D001323:Autoantibodies / Q000502:physiology*; D001362:Avoidance Learning; D001522:Behavior, Animal; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000276:immunology; D005260:Female; D007116:Immunization, Passive; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism; D009420:Nervous System / Q000196:embryology* / Q000254:growth & development / Q000276:immunology*; D009687:Nuclear Proteins / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
C434186:ACBP14 protein, human; D001323:Autoantibodies; D008562:Membrane Glycoproteins; D009687:Nuclear Proteins; C025363:mannoproteins