title: Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain.
abstract: Neuropathic pain is caused by nervous-system lesions. Early studies on the pathomechanisms of this abnormal pain state have focused on the directly injured fibers and neurons. Here, we present recently accumulating data about the contribution of the primary afferent neurons spared from direct injury to the pathomechanisms of neuropathic pain. The phenotypic changes in the spared neurons are similar to those in the neurons in peripheral inflammation models, as opposed to those in the directly injured neurons. Electrophysiological changes and behavioral data also favor the contribution of the spared neurons. These attractive targets of study will give us new approaches for understanding the abnormal pain.
authors.affiliation: Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Japan. tfukuoka@hyo-med.ac.jp
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fukuoka
authors.forename: Koichi
authors.initials: K
authors.lastname: Noguchi
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology*; D000818:Animals; D004594:Electrophysiology; D005727:Ganglia, Spinal / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000150:complications; D018836:Inflammation Mediators / Q000502:physiology; D008026:Ligation; D023421:Models, Animal; D009437:Neuralgia / Q000209:etiology / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000503:physiopathology; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000502:physiology; D019051:Rhizotomy; D012584:Sciatic Nerve / Q000293:injuries; D012585:Sciatica / Q000209:etiology / Q000503:physiopathology; D009435:Synaptic Transmission
chemical_list: D018836:Inflammation Mediators; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter