title: Symptomatic neurological epidural metastasis with interleukin-2 therapy in metastatic renal cell carcinoma.
abstract: Interleukin-2 has known efficacy in the treatment of metastatic renal cell carcinoma but it also has adverse effects mediated by an inflammatory mechanism and capillary leak syndrome. The authors report the case of a patient with a metastatic renal cell carcinoma who had an asymptomatic intra-epidural metastasis in the thoracic spine, which became symptomatic during IL-2 administration without any recurrence after specific treatment by surgery and radiotherapy.
authors.affiliation: Institut Bergonié, Regional Cancer Center, Bordeaux, France. trufflandier@bergonie.org
authors.forename: Nathalie
authors.initials: N
authors.lastname: Trufflandier
authors.forename: Olivier
authors.initials: O
authors.lastname: Gille
authors.forename: Jean
authors.initials: J
authors.lastname: Palussière
authors.forename: Loïc
authors.initials: L
authors.lastname: Prié
authors.forename: Vincent
authors.initials: V
authors.lastname: Pointillart
authors.forename: Alain
authors.initials: A
authors.lastname: Ravaud
mesh_terms: D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D015174:Epidural Neoplasms / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013904:Thoracic Vertebrae
chemical_list: D007376:Interleukin-2