A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes.
Aging is a major risk factor for neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced overproduction of reactive oxygen species (ROS) may give rise to oxidative stress which can induce neuronal damage, ultimately leading to neuronal death by apoptosis or necrosis. A large body of evidence indicates that oxidative stress is involved in the pathogenesis of AD, PD, and ALS. An increasing number of studies show that nutritional antioxidants (especially Vitamin E and polyphenols) can block neuronal death in vitro, and may have therapeutic properties in animal models of neurodegenerative diseases including AD, PD, and ALS. Moreover, clinical data suggest that nutritional antioxidants might exert some protective effect against AD, PD, and ALS. In this paper, the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed. Particular emphasis will be given to the role played by the nuclear transcription factor-kappaB (NF-kappaB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-kappaB function and their relevance in the pathophysiology of neurodegenerative diseases will also be examined.
Esposito
Ennio
E
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro, Chieti, Italy. esposito@cmns.mnegri.it
Rotilio
Domenico
D
Di Matteo
Vincenzo
V
Di Giulio
Camillo
C
Cacchio
Marisa
M
Algeri
Sergio
S
D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism*; D004032:Diet; D006801:Humans; D019636:Neurodegenerative Diseases / Q000178:diet therapy* / Q000378:metabolism*
D000975:Antioxidants