title: Assessment of pulmonary perfusion with ultrafast projection magnetic resonance angiography in comparison with lung perfusion scintigraphy in patients with malignant stenosis.
abstract: OBJECTIVE
  The aim of this study was to demonstrate and measure perfusion deficits caused by central bronchogenic carcinoma and to compare magnetic resonance angiography (MRA) perfusion data with data of perfusion scintigraphy. The diagnostic value of 2D MRA in detection of malignant pulmonary artery stenosis in comparison with conventional DSA was investigated.
  
  
  METHODS
  Eighteen patients were included in the study. MRA, conventional pulmonary angiograms, and pulmonary perfusion scintigrams were performed. MRA and DSA were compared and MR pulmonary perfusion data were assessed and compared with scintigraphical data.
  
  
  RESULTS
  Perfusion defect could be demonstrated and localized in all patients. A quantitative perfusion deficit and a side dependent perfusion ratio could be evaluated. There was statistically significant correlation between MR perfusion and scintigraphically acquired data. 2D MRA showed a high correlation for detection and grading of stenosis compared with angiograms.
  
  
  CONCLUSIONS
  Pulmonary perfusion could be demonstrated by using an ultrafast 2D projection MR DSA sequence. This technique allows measurement and quantification of pulmonary perfusion abnormalities in patients with malignant stenosis with statistically significant correlation to perfusion scintigraphy. The diagnostic potency in the evaluation of malignant pulmonary artery stenosis compared with conventional DSA could be shown.
authors.affiliation: Department of Diagnostic Radiology, University of Freiburg, Germany. stefan.lehnhardt@klinikum.uni-freiburg.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Lehnhardt
authors.forename: Jan
authors.initials: J
authors.lastname: Thorsten Winterer
authors.forename: Ralph
authors.initials: R
authors.lastname: Strecker
authors.forename: Stephan
authors.initials: S
authors.lastname: Hogerle
authors.forename: Georg
authors.initials: G
authors.lastname: Herget
authors.forename: Viviane
authors.initials: V
authors.lastname: Geens
authors.forename: Joerg
authors.initials: J
authors.lastname: Laubenberger
authors.forename: Peter
authors.initials: P
authors.lastname: Uhrmeister
mesh_terms: D015901:Angiography, Digital Subtraction; D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D009367:Neoplasm Staging; D011651:Pulmonary Artery; D011877:Radionuclide Imaging