Component of Zingiber officinale that improves the enhancement of small intestinal transport.
6-Shogaol, a constituent of Zingiber officinale, improved carbachol-induced accelerated small intestinal transit in vivo, as well as improving longitudinal muscle contraction induced by low-frequency electrical stimulation of the isolated guinea pig small intestine in vitro. In addition, 6-shogaol ameliorated BaCl(2) -induced hyperperistalsis of the small intestine in vivo.
Hashimoto
Kazunori
K
Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ami-machi, Ibaraki 300-1192, Japan. hashimoto_kazunori@mail.tsumura.co.jp
Satoh
Kazuko
K
Murata
Pin
P
Makino
Bunsho
B
Sakakibara
Iwao
I
Kase
Yoshio
Y
Ishige
Atsushi
A
Higuchi
Masami
M
Sasaki
Hiroshi
H
D000818:Animals; D017609:Barium Compounds; D002396:Catechols / Q000008:administration & dosage / Q000494:pharmacology*; D002712:Chlorides; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000187:drug effects*; D020939:Zingiber officinale; D006168:Guinea Pigs; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects*; D008517:Phytotherapy; D018517:Plant Roots
D017609:Barium Compounds; D002396:Catechols; D002712:Chlorides; C024986:barium chloride; C040115:shogaol