Selection of mutant cell lines resistant to infection by Chlamydia spp [corrected].
The lytic outcome of natural infection by Chlamydia trachomatis was exploited to select CHO (Chinese hamster ovary) cells, following chemical mutagenesis, that were deficient in their ability to sustain productive chlamydial infection. Four distinct mutant cell phenotypes with defects in either attachment or postattachment mechanisms that are required for infection by C. trachomatis and Chlamydia pneumoniae were characterized.
Fudyk
Trevor
T
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720, USA.
Olinger
Lynn
L
Stephens
Richard S
RS
D000818:Animals; D001422:Bacterial Adhesion; D016466:CHO Cells; D002460:Cell Line; D002692:Chlamydia trachomatis / Q000502:physiology*; D016993:Chlamydophila pneumoniae / Q000502:physiology*; D006224:Cricetinae; D016296:Mutagenesis; D009154:Mutation