title: Oscillations in peripheral arterial tone in congestive heart failure patients: a new marker for Cheyne-Stokes breathing.
abstract: Cheyne-Stokes breathing (CSB), which is a prevalent finding in congestive heart failure (CHF) patients, has been shown to be of prognostic value. The oscillations in respiration were shown to be associated with oscillations in sympathetic nerve activation. We tested the hypothesis that the peripheral arterial tone (PAT) as measured by a novel finger plethysmograph can be used to detect CSB. Using a novel technique to measure the PAT, we monitored 10 patients with advanced CHF simultaneously with conventional polysomnographic recordings for either 1 or 2 nights. Records were scored for CSB during 3-min periods based on either respiratory effort and nasal-buccal airflow or on the PAT signal alone. The PAT sensitivity and specificity for the detection of periods containing CSB were 91 and 91% for the entire recording, 90.7 and 92.9% for non-REM sleep, 90.7 and 70% for REM sleep, and 73 and 97.3% for awake periods, respectively. PAT is a reliable marker of CSB in CHF patients. The novel finger plethysmograph can be used for screening and monitoring CSB.
authors.affiliation: Cardiac Institute, Heart Failure Clinic, The Chaim Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
authors.forename: Dov
authors.initials: D
authors.lastname: Freimark
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Adler
authors.forename: Jacob
authors.initials: J
authors.lastname: Sheffy
authors.forename: Doris
authors.initials: D
authors.lastname: Schechter
authors.forename: Ehud
authors.initials: E
authors.lastname: Schwammenthal
authors.forename: Itay
authors.initials: I
authors.lastname: Wiser
authors.forename: Michael
authors.initials: M
authors.lastname: Motro
authors.forename: Peretz
authors.initials: P
authors.lastname: Lavie
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis; D002639:Cheyne-Stokes Respiration / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000150:complications / Q000503:physiopathology; D010100:Oxygen / Q000032:analysis*; D012680:Sensitivity and Specificity; D012890:Sleep / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology
chemical_list: D015415:Biomarkers; D010100:Oxygen