title: Effect of Cervitec on mutans streptococci in plaque and on caries formation on occlusal fissures of erupting permanent molars.
abstract: The aim of this study was to evaluate the effect of Cervitec on the abundance of mutans streptococci (MS) in occlusal dental plaque and on 2-year caries increment of partly erupting first permanent molars. Sixteen healthy schoolchildren aged 6-8 years, with at least 2 sound contralateral partly erupted permanent molars, received diet counselling and daily parental supervised toothbrushing with a fluoride dentifrice. Stimulated saliva samples were collected at baseline and after 1 year to evaluate MS levels. In a split-mouth design, Cervitec varnish was applied to one of the teeth at baseline and after 3 and 6 months, while the other tooth in the same jaw was a control. At the 9-month follow-up the teeth were in occlusal contact. At this time, varnish was not applied. At 3 and 6 months after the first application of varnish a significant suppression of MS was observed in plaque. Caries investigations, performed at baseline and every 3 months during the 2 years after the start of the study, showed that all the teeth treated with the varnish were free of caries after 2 years, whereas 8/16 control teeth developed incipient caries. In conclusion, our results suggest that treatment with Cervitec reduces MS in plaque on erupting permanent molars and can lead to a significant decrease in caries incidence.
authors.affiliation: Department of Pediatric Dentistry, Institute of Health Sciences, Paulista University, Brazil. anamagar@uol.com.br
authors.forename: A M P G
authors.initials: AM
authors.lastname: Araujo
authors.forename: G M C C
authors.initials: GM
authors.lastname: Naspitz
authors.forename: A
authors.initials: A
authors.lastname: Chelotti
authors.forename: S
authors.initials: S
authors.lastname: Cai
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002648:Child; D002710:Chlorhexidine / Q000008:administration & dosage*; D015169:Colony Count, Microbial; D003731:Dental Caries / Q000517:prevention & control*; D003750:Dental Fissures / Q000473:pathology; D003773:Dental Plaque / Q000382:microbiology*; D004338:Drug Combinations; D006801:Humans; D008963:Molar; D010150:Paint; D012463:Saliva / Q000382:microbiology; D018709:Statistics, Nonparametric; D013295:Streptococcus mutans / Q000187:drug effects*; D013943:Thymol / Q000008:administration & dosage*
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; D002710:Chlorhexidine