[Chemically-induced differentiation of the tumor cell lines].
We considered the biological effects of some chemical compounds, that stimulate cell differentiation, on the cells of tumor lines. Induced changes were analyzed in the expression of several transcriptional factors involved in the regulation of cell proliferation and apoptosis. Based on the generalized information about differentiating, apoptogenic, and antiproliferative effects of chemical inducers of differentiation, a conclusion was drawn that they affect the sensitivity of differentiated cells to the lytic action of natural killer cells.
Anisimov
A G
AG
Petrozavodsk State University, pr. Lenina 33, Petrozavodsk, 185640 Russia.
Volkova
T O
TO
Chekmasova
A A
AA
Nemova
N N
NN
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D014407:Tumor Cells, Cultured
D004791:Enzyme Inhibitors; D007155:Immunologic Factors