Preparation of isoprostanes and neuroprostanes.
A new approach to isoprostanes and neuroprostanes featuring cis-dialkyl stereochemistry at the cyclopentane ring has been developed by employing an intramolecular cross-coupling reaction of an alkyl iodide and a tethered alkenylsiloxane for stereoselective installation of a functionalized omega-side chain.
Quan
Long Guo
LG
Department of Chemistry, University of Alabama, Tuscaloosa, Alabama 35487, USA.
Cha
Jin Kun
JK
D015237:Dinoprost / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D004281:Docosahexaenoic Acids / Q000138:chemical synthesis; D028421:Isoprostanes / Q000138:chemical synthesis*; D013237:Stereoisomerism
D028421:Isoprostanes; D004281:Docosahexaenoic Acids; D015237:Dinoprost