Successful treatment of steroid-resistant minimal change disease with mycophenolate mofetil.
Mycophenolate mofetil has been reported to be effective in the treatment of steroid-responsive minimal change disease. We report a case of steroid- and cyclosporin-resistant minimal change disease with severe nephrotic syndrome that responded to mycophenolate mofetil with complete remission. The patient remains in complete remission 1 year after the discontinuation of mycophenolate mofetil. The presented case argues for the need of a prospective controlled study with the goal of evaluating the efficacy of mycophenolate mofetil in the therapy of steroid-resistant minimal change disease.
Mogyorósi
András
A
Departments of Medicine and Pathology, Virginia Commonwealth University/Medical College of Virginia and Hunter Holmes McGuire VAMC, Richmond, Va. 23249, USA. amogyoro@hsc.vcu.edu
Lippman
H Robert
HR
Feldman
George M
GM
D004351:Drug Resistance; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D009402:Nephrosis, Lipoid / Q000188:drug therapy*; D013256:Steroids / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D013256:Steroids; D009173:Mycophenolic Acid