Antihyperalgesia effect of BmK AS, a scorpion toxin, in rat by intraplantar injection.
The antihyperalgesia effect of BmK AS, a novel sodium channel-specific polypeptide modulator from Chinese scorpion venom in rats was investigated in this study. PWLs (paw withdrawal latency) were increased to 150+/-28, 203+/-34 and 250+/-17% of the control by administration of BmK AS (10 microl) at the concentration of 0.001, 0.01 and 0.1 mg/ml in carrageenan-induced inflamed rats, respectively. Meanwhile, PWLs were enhanced to about 126+/-4, 132+/-4 and 140+/-6% of the control at the same applied concentration of BmK AS in normal rats. The results suggest that BmK AS can induce peripheral antihyperalgesia and antinociception, which probably by modulating the sodium channel on nociceptive afferent pathway.
Chen
Bing
B
Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, PR China.
Ji
Yonghua
Y
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006614:Hindlimb; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D008297:Male; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010455:Peptides / Q000008:administration & dosage* / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D012604:Scorpion Venoms / Q000008:administration & dosage* / Q000302:isolation & purification
D000700:Analgesics; C119407:BmK AS polypeptide; D010455:Peptides; D012604:Scorpion Venoms