title: Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity.
abstract: Four new compounds, crocusatins F (1), G (2), H (3), and I (4a), together with 21 known compounds, were isolated from an aqueous extract of the stigmas of Crocus sativus (saffron). The structures of 1-4 were established by spectral methods. The tyrosinase inhibitory activities of all 25 compounds isolated were evaluated in vitro using mushroom tyrosinase. Among them, crocusatin H (3), crocin-1 (5), and crocin-3 (6) showed significant tyrosinase inhibitory activity.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, Republic of China.
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Li
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D027622:Crocus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D013057:Spectrum Analysis
chemical_list: D004791:Enzyme Inhibitors; D014442:Monophenol Monooxygenase