title: Gene action in the aging brain: an evolutionary biological perspective.
abstract: The evolutionary biologic theory has up to now invoked only two modalities of gene action as examples of gene actions that escape the force of natural selection and, hence, are responsible for senescent phenotypes. I here suggest a more comprehensive classification of such gene actions and give possible examples of their potential relevance to brain aging.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Martin
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D005075:Biological Evolution; D001921:Brain / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology*; D006801:Humans