Pseudohyphal growth in a dimorphic yeast, Candida maltosa, after disruption of the C-GCN4 gene, a homolog of Saccharomyces cerevisiae GCN4.
The transcriptional activator protein Gcn4p increases the transcription of many genes that code for amino acid synthesis genes during amino acid starvation in Saccharomyces cerevisiae. Here we showed that after the disruption of C-GCN4, a homolog in Candida maltosa of GCN4 in S. cerevisiae, formed pseudohyphae in minimal medium. This is the first report that a GCN4 homolog is involved in the control of morphological transition.
Takaku
Hiroaki
H
Department of Biotechnology, University of Tokyo, Japan.
Horiuchi
Hiroyuki
H
Takagi
Masamichi
M
Ohta
Akinori
A
D002175:Candida / Q000166:cytology / Q000235:genetics* / Q000254:growth & development*; D004268:DNA-Binding Proteins / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics*; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D013997:Time Factors; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D012331:RNA, Fungal; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases