Protein oxidation during aging of the nematode Caenorhabditis elegans.
The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function.
Ishii
Naoaki
N
Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan. nishii@is.icc.u-tokai.ac.jp
Goto
Sataro
S
Hartman
Philip S
PS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000254:growth & development*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D003580:Cytochromes / Q000235:genetics / Q000502:physiology; D045303:Cytochromes b; D051858:Forkhead Transcription Factors; D008136:Longevity / Q000235:genetics; D008928:Mitochondria / Q000502:physiology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D011972:Receptor, Insulin / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D003580:Cytochromes; D051858:Forkhead Transcription Factors; C472666:MEV-1 protein, C elegans; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; D045303:Cytochromes b; D019869:Phosphatidylinositol 3-Kinases; C442437:tkr-1 protein, C elegans; C100662:AGE-1 protein, C elegans; C107483:DAF-2 protein, C elegans; C472665:Old-2 protein, C elegans; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin