Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America.
PCR-SSOP identification procedures for IL-2, IL-6, IL-10, TNF-alpha and TNF-beta cytokine polymorphisms have been developed. Application of the procedures to a range of diverse geographically distributed populations has identified ethnic differences within the groups studied. Five populations were investigated, Northern Ireland, South African Zulu, Omani, Singapore Chinese and Mexican Mestizos.
Meenagh
Ashley
A
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland.
Williams
Fionnuala
F
Ross
Owen A
OA
Patterson
Chris
C
Gorodezky
Clara
C
Hammond
Mike
M
Leheny
William A
WA
Middleton
Derek
D
D000349:Africa; D000483:Alleles; D001208:Asia; D016207:Cytokines / Q000235:genetics*; D005060:Europe; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D008233:Lymphotoxin-alpha / Q000235:genetics; D008877:Middle East; D011110:Polymorphism, Genetic; D013020:South America; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D007376:Interleukin-2; D015850:Interleukin-6; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10