Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans.
Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.
Wanten
Geert J
GJ
Department of Gastroenterology, University Medical Center Nijmegen, Nijmegen, The Netherlands. G.Wanten@gastro.azn.nl
Netea
Mihai G
MG
Naber
Ton H
TH
Curfs
Jo H
JH
Jacobs
Liesbeth E
LE
Verver-Jansen
Trees J
TJ
Kullberg
Bart-Jan
BJ
D002176:Candida albicans / Q000254:growth & development; D002177:Candidiasis / Q000209:etiology*; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007371:Interferon-gamma / Q000096:biosynthesis; D009504:Neutrophils / Q000276:immunology; D014280:Triglycerides / Q000008:administration & dosage / Q000009:adverse effects*
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D007371:Interferon-gamma