Transcription activation: unveiling the essential nature of TFIID.
The TAF subunits of TFIID mediate activation of subsets of the eukaryotic genome. Recent results demonstrate that TFIID is recruited to promoters in an activator-specific manner involving functional interaction between upstream regulatory elements and the core promoter, thereby coordinating the expression of distinct sets of genes.
Chen
Bo-Shiun
BS
Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Hampsey
Michael
M
D000818:Animals; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D021122:Protein Subunits; D035381:TATA-Binding Protein Associated Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D035362:Transcription Factor TFIID / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D015533:Transcriptional Activation
D046911:Macromolecular Substances; D021122:Protein Subunits; D035381:TATA-Binding Protein Associated Factors; D035362:Transcription Factor TFIID