title: Association of systemic lupus erythematosus and hypermobility.
abstract: OBJECTIVE
  To investigate joint laxity in patients with systemic lupus erythematosus (SLE).
  
  
  METHODS
  University Hospital.
  
  
  METHODS
  81 patients with SLE (1999 American College of Rheumatology criteria; 72 (89%) women and nine (11%) men, mean age 42.9 (SD 16.1) years), who regularly attended a specialist SLE clinic were examined. The control group comprised 280 patients attending a general practitioner (193 (69%) women and 87 (31%) men, mean age 44.7 (SD 11.2) years). Joint laxity was measured according to the criteria of Beighton et al (total score 4 or more). A regression analysis was performed.
  
  
  RESULTS
  Thirty nine (48%) patients with SLE and 42 (15%) of the control group were hypermobile. A logistic regression model was developed. The odds ratio of the association between laxity and SLE after adjustment for age and sex was 2.31 in the group younger than 49 years, and 17.99 in the group aged 49 years or older. Neither the clinical and analytical profile nor the use of corticosteroids was related to joint laxity.
  
  
  CONCLUSIONS
  Patients with SLE showed more hypermobility than controls. Hypermobility was more profound in older patients with SLE (> or =49 years). Joint laxity was not associated with any clinical or analytical pattern. Treatment with corticosteroids was not related to joint laxity.
authors.affiliation: Rheumatology Section, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gumà
authors.forename: A
authors.initials: A
authors.lastname: Olivé
authors.forename: J
authors.initials: J
authors.lastname: Roca
authors.forename: J
authors.initials: J
authors.lastname: Forcada
authors.forename: J C
authors.initials: JC
authors.lastname: Duró
authors.forename: S
authors.initials: S
authors.lastname: Holgado
authors.forename: E
authors.initials: E
authors.lastname: Casado
authors.forename: X
authors.initials: X
authors.lastname: Mezquiriz
authors.forename: X
authors.initials: X
authors.lastname: Tena
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000209:etiology*; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012189:Retrospective Studies; D012737:Sex Factors