[Relationship between salivary lipid peroxidation and the strategy of local dichloran gel treatment for periodontitis].
The effects of dicloran gel in combination with antibiotics on salivary lipid peroxidation were evaluated in 18 patients aged 23-68 years with chronic generalized rapidly progressing periodontitis. Lipid peroxidation and activity of antioxidant systems surpassed the normal values 2-4-fold in periodontitis patients before treatment. After therapy with metrogil-dent these parameters decreased (p < 0.05). Injection of dicloran gel before antibiotic therapy induced a decrease in these parameters within approximately 30 min. If dicloran gel was injected after metrogil-dent, the maximum decrease in oxidative processes and antioxidant system activity was observed as soon as in 15 min.
Grudianov
A I
AI
Ovchinnikova
V V
VV
Serebriakova
L E
LE
D000328:Adult; D000368:Aged; D000814:Aniline Compounds / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy* / Q000378:metabolism*; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*
D000814:Aniline Compounds; D000890:Anti-Infective Agents; D005782:Gels; D008795:Metronidazole; C004354:dicloran