Development of co- and post-translational synthetic strategies to C-neoglycopeptides.
[reaction: see text] The synthesis of stable, C-linked analogues of glycopeptides is being investigated with two complementary synthetic strategies, co-translational and post-translational glycopeptide synthesis. The key feature of the present approach lies in an effective olefin cross-metathesis reaction that allows formation of both glycoamino acids and glycopeptides.
McGarvey
Glenn J
GJ
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA. gjm@virginia.edu
Benedum
Tyler E
TE
Schmidtmann
Frank W
FW
D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
D006020:Glycopeptides