title: Diagnosis of atrophic gastritis from a serum sample.
abstract: On the basis of the levels of serum pepsinogen I (S-PGI) and gastrin-17 (S-G-17) as well as Helicobacter pylori - antibodies assayed from a blood sample it is possible to establish with high sensitivity and specificity whether the patient has gastritis, whether the gastritis is atrophic or not and in which part of the stomach the atrophic changes are located. The test enables the identification of patients whose risk of gastric cancer, of the consequences of vitamin B12 deficiency (e.g. elevated levels of homocysteine) or of peptic ulcer is considerably increased and who can then undergo gastroscopy. It also facilitates the diagnosis of non-atrophic Helicobacter gastritis enabling treatment before endoscopy.
authors.affiliation: Helsinki University Central Hospital, Department of Pathology, Espoo, Finland. pentti.sipponen@hus.fi
authors.forename: Pentti
authors.initials: P
authors.lastname: Sipponen
authors.forename: Matti
authors.initials: M
authors.lastname: Härkönen
authors.forename: Arto
authors.initials: A
authors.lastname: Alanko
authors.forename: Osmo
authors.initials: O
authors.lastname: Suovaniemi
mesh_terms: D005387:Finland / Q000453:epidemiology; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D016481:Helicobacter Infections / Q000150:complications; D006801:Humans; D020116:Pepsinogen A / Q000097:blood; D010437:Peptic Ulcer / Q000175:diagnosis / Q000209:etiology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000209:etiology; D014806:Vitamin B 12 Deficiency / Q000209:etiology
chemical_list: D005755:Gastrins; C013550:gastrin 17; D020116:Pepsinogen A