Delayed lethal response to Aspergillus fumigatus infection in sarcoma 180 tumor-bearing mice.
A longer survival and a decrease in the number of fungal cells in kidneys and brain were observed in groups of mice inoculated with Aspergillus fumigatus conidia 2-3 weeks (especially 3 weeks) after sarcoma 180 tumor transplantation compared to groups of non-tumor-bearing (control) mice inoculated with fungal cells only. The 3-4-week tumor-bearing mice had significantly decreased levels of serum iron and increased levels of unbound iron binding capacity in the serum compared to those of the non-tumor-bearing mice.
Okawa
Yoshio
Y
The Second Department of Hygienic Chemistry, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Sendai Aoba-ku, Miyagi, 981-8558 Japan. okawa@tohoku-pharm.ac.jp
Murata
Yoshiko
Y
Suzuki
Masuko
M
Ito
Makoto
M
Hotchi
Masao
M
Suzuki
Shigeo
S
D000818:Animals; D001228:Aspergillosis / Q000150:complications* / Q000473:pathology / Q000517:prevention & control; D001232:Aspergillus fumigatus / Q000276:immunology / Q000378:metabolism; D006651:Histocytochemistry; D007113:Immunity, Innate / Q000276:immunology; D007501:Iron / Q000032:analysis; D008297:Male; D051379:Mice; D012510:Sarcoma 180 / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D016019:Survival Analysis; D013997:Time Factors; D014407:Tumor Cells, Cultured
D007501:Iron