title: Primary mucosa-associated lymphoid tissue (MALT) lymphoma arising from the male urethra. A case report and review of the literature.
abstract: Primary non-Hodgkin's lymphomas rarely arise from the lower urinary tract, the urethra being the most uncommon site of origin. Herein, we report the immunohistochemical findings of a case of primary marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arising from the male urethra. To clarify the clinicopathological findings of primary urethral lymphoma, we reviewed 14 previously reported cases. A 56-year-old man presented with gross hematuria. Cystourethroscopy demonstrated a nodular bulge of the urethral wall. Histologically, a transurethral biopsy specimen showed a dense lymphoplasmacytoid infiltrate in the urethral mucosa. The tumor cells were composed of centrocyte-like cells, plasma cells and plasmacytoid cells. A few plasma cells contained intracytoplasmic pseudoinclusions (Dutcher bodies). Immunohistochemical study revealed monotypic intracytoplasmic kappa-light chain in the plasma cells and plasmacytoid cells. The patient received a total of 50 Gy extrabeam irradiation. Follow-up 21 months later did not disclose any sign of local or other recurrences.
authors.affiliation: Department of Urology, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Masuda
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Tsujii
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Hideo
authors.initials: H
authors.lastname: Moriguchi
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Honda
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D003558:Cystoscopy; D003593:Cytoplasm / Q000378:metabolism; D004724:Endoscopy; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014523:Urethral Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains