title: Alkaloids from Menispermum dauricum.
abstract: The alkaloids, dechloroacutumidine and 1-epidechloroacutumine, together with three known alkaloids, acutumidine, acutumine, and dechloroacutumine, were isolated from the rhizomes of Menispermum dauricum and their structures established by spectral and chemical methods. The cytotoxicity of each compound against the growth of human cell lines was studied, and acutumine selectively inhibited T-cell growth.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, People's Republic of China.
authors.forename: Bing-Wu
authors.initials: BW
authors.lastname: Yu
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Chen
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Kin-Fin
authors.initials: KF
authors.lastname: Cheng
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Li
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Qin
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001402:B-Lymphocytes / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D031603:Menispermum / Q000737:chemistry*; D015394:Molecular Structure; D009928:Organ Specificity; D027343:Rhizome / Q000737:chemistry; D013141:Spiro Compounds / Q000302:isolation & purification / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
chemical_list: C473531:1-epidechloroacutumine; D000470:Alkaloids; D013141:Spiro Compounds; C442344:acutumine; C473530:dechloroacutumidine