Hormones and weight change.
Dysregulation of body weight has been a common complaint of women on hormonal contraception but an inconsistent event in controlled clinical studies. In a prospective trial to evaluate the relationship between depot medroxyprogesterone acetate (DMPA) and change in energy intake, energy expenditure and weight change, no effect from DMPA could be documented. These results refute a causal relationship between use of DPMA and increased weight. While weight gain and use of contraception may be common concomitant events in a population with a substantial propensity for weight fluctuation, the objective data suggest that factors other than contraceptive method are important. The controlled data have major implications for appropriate management and counseling of women seeking a highly effective method of protection against pregnancy.
Pelkman
Christine
C
Department of Exercise and Nutrition Sciences, State University of New York at Buffalo, 15 Farber Hall, 3435 Main Street, Buffalo, NY 14214-3000, USA.
D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000009:adverse effects*; D003692:Delayed-Action Preparations / Q000009:adverse effects; D004311:Double-Blind Method; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D014481:United States; D015430:Weight Gain / Q000187:drug effects*
D003271:Contraceptive Agents, Female; D003692:Delayed-Action Preparations; D017258:Medroxyprogesterone Acetate