[Progress in the study of CCN family].
The last 5-6 years have seen the emergence of a new gene family that currently comprises CTGF, Cyr61, nov, elm1, HICP and WISP-3. The translational products of most CCN family members are secreted proteins that contain 343 to 381 amino-acid residues to compose 4 distinct structural modules, each having 38 conserved cysteine residues. These proteins have a variety of properties to affect the cellular behaviors such as growth, differentiation, adhesion and locomotion. They may play important roles in pregnancy, development and differentiation, angiogenesis, wound repair, fibrotic disorders, inflammation and tumor genesis.
Su
Bing-Yin
BY
Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, China. subingyin@yahoo.com.cn
Cai
Wen-Qin
WQ
D000818:Animals; D055511:CCN Intercellular Signaling Proteins; D002417:Cattle; D002454:Cell Differentiation / Q000502:physiology; D055513:Connective Tissue Growth Factor; D055515:Cysteine-Rich Protein 61; D005544:Forecasting; D006801:Humans; D017874:Immediate-Early Proteins / Q000737:chemistry / Q000502:physiology*; D018969:Insulin-Like Growth Factor Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D009363:Neoplasm Proteins / Q000737:chemistry / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D055514:Nephroblastoma Overexpressed Protein; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D051381:Rats; D012097:Repressor Proteins / Q000737:chemistry / Q000502:physiology; D013552:Swine; D014945:Wound Healing / Q000502:physiology
D055511:CCN Intercellular Signaling Proteins; C501848:CCN1 protein, human; C491850:CCN1 protein, mouse; C501849:CCN1 protein, rat; C526317:CCN2 protein, human; C526318:CCN2 protein, mouse; C526316:CCN2 protein, rat; C526319:CCN3 protein, human; C116396:CCN4 protein, human; C492067:CCN4 protein, mouse; C492066:CCN4 protein, rat; C400081:CCN6 protein, human; C526320:Ccn3 protein, mouse; D055515:Cysteine-Rich Protein 61; D017874:Immediate-Early Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D055514:Nephroblastoma Overexpressed Protein; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D055513:Connective Tissue Growth Factor