Age-dependent phosphate homeostasis is regulated by a circulating factor.
To evaluate the age-dependent phosphate homeostasis, we studied the serum inorganic phosphate (P(i)) concentration in 78 recipients, aged 5-25 years, a year after renal transplantation (RT). The significant age-dependent decline of the serum P(i) concentration was observed in recipients (p < 0.0001) as well as in normal children. Our study revealed that a circulating factor may play a central role in the age-dependent change of phosphate regulation in human.
Matsumoto
Naoko
N
Department of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan. naoko@pine.memail.jp
Komatsu
Yasuhiro
Y
Hattori
Motoshi
M
Shiraga
Hiroshi
H
Ito
Katsumi
K
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging; D001798:Blood Proteins / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006706:Homeostasis; D006801:Humans; D016030:Kidney Transplantation; D010710:Phosphates / Q000097:blood*
D001798:Blood Proteins; D010710:Phosphates