title: Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome.
abstract: Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing "treasure trove" of functional data regarding the ribosome that has accumulated over the past decades. Here we try a systematic synopsis of these ribosomal functions in light of the cryo-electron microscopic structures (resolution >7 A) and the atomic x-ray structures (>2.4 A) of the ribosome.
authors.affiliation: Max-Planck-Institut für Molekulare Genetik, AG Ribosomen, Ihnestr. 73, Berlin, D-14195 Berlin, Germany.
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Wilson
authors.forename: Gregor
authors.initials: G
authors.lastname: Blaha
authors.forename: Sean R
authors.initials: SR
authors.lastname: Connell
authors.forename: Pavel V
authors.initials: PV
authors.lastname: Ivanov
authors.forename: Holger
authors.initials: H
authors.lastname: Jenke
authors.forename: Ulrich
authors.initials: U
authors.lastname: Stelzl
authors.forename: Yoshika
authors.initials: Y
authors.lastname: Teraoka
authors.forename: Knud H
authors.initials: KH
authors.lastname: Nierhaus
mesh_terms: D018388:Codon, Terminator / Q000378:metabolism; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D010452:Peptide Biosynthesis; D020653:Peptide Elongation Factor G / Q000378:metabolism; D010444:Peptide Elongation Factor Tu / Q000378:metabolism; D010448:Peptide Initiation Factors / Q000378:metabolism; D010454:Peptide Termination Factors / Q000378:metabolism; D010458:Peptidyl Transferases / Q000378:metabolism; D014176:Protein Biosynthesis / Q000502:physiology*; D011487:Protein Conformation; D012335:RNA, Ribosomal / Q000737:chemistry / Q000378:metabolism; D012343:RNA, Transfer / Q000737:chemistry / Q000378:metabolism; D012269:Ribosomal Proteins / Q000737:chemistry / Q000502:physiology; D012270:Ribosomes / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D018388:Codon, Terminator; D020653:Peptide Elongation Factor G; D010448:Peptide Initiation Factors; D010454:Peptide Termination Factors; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; D012343:RNA, Transfer; D010458:Peptidyl Transferases; D010444:Peptide Elongation Factor Tu