title: Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers.
abstract: BACKGROUND
  Flesinoxan is a highly potent and selective 5-HT(1A) agonist and appears to be a potentially interesting neuroendocrine serotonergic probe.
  
  
  OBJECTIVE
  We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers.
  
  
  METHODS
  In a double-blind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min.
  
  
  RESULTS
  Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent.
  
  
  CONCLUSIONS
  These results showed the role of 5-HT(1A) mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.
authors.affiliation: Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium. wpitchot@chu.ulg.ac.be
authors.forename: William
authors.initials: W
authors.lastname: Pitchot
authors.forename: Jacques
authors.initials: J
authors.lastname: Wauthy
authors.forename: Michel
authors.initials: M
authors.lastname: Hansenne
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Pinto
authors.forename: Sonia
authors.initials: S
authors.lastname: Fuchs
authors.forename: Jean
authors.initials: J
authors.lastname: Reggers
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Legros
authors.forename: Marc
authors.initials: M
authors.lastname: Ansseau
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010907:Pituitary Hormones / Q000097:blood*; D011985:Receptors, Serotonin / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D018709:Statistics, Nonparametric
chemical_list: D010879:Piperazines; D010907:Pituitary Hormones; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; C056895:flesinoxan; D006854:Hydrocortisone