title: Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library.
abstract: Inhibitors of FGF-2 binding to a heparin-albumin conjugate were identified by ELISA from a library of glucuronic acid derivatives. These compounds were also inhibitors of endothelial cell survival that is dependant on FGF-2 and heparin or heparan sulfate proteoglycans. The results indicate that these bioactive compounds may prove useful as lead structures for the further development of pharmaceutical agents capable of modulating biological activity of FGF-2.
authors.affiliation: Department of Chemistry, Centre for Synthesis and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland. paul.v.murphy@ucd.ie
authors.forename: Paul V
authors.initials: PV
authors.lastname: Murphy
authors.forename: Nigel
authors.initials: N
authors.lastname: Pitt
authors.forename: Alan
authors.initials: A
authors.lastname: O'Brien
authors.forename: Philomena M
authors.initials: PM
authors.lastname: Enright
authors.forename: Amanda
authors.initials: A
authors.lastname: Dunne
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wilson
authors.forename: Rhona M
authors.initials: RM
authors.lastname: Duane
authors.forename: Kathy M
authors.initials: KM
authors.lastname: O'Boyle
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001011:Aorta; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D016222:Fibroblast Growth Factor 2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology*; D006493:Heparin / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D020533:Angiogenesis Inhibitors; D016222:Fibroblast Growth Factor 2; D020723:Glucuronic Acid; D006493:Heparin