title: Central venous catheters in home infusion care: outcomes analysis in 50,470 patients.
abstract: OBJECTIVE
  Outpatient home infusion therapy is increasing; however, little data exist on the outcomes of patients receiving care. The purpose of this study was to document the natural history of central venous catheters (CVCs) used in home infusion care to determine the rate and type of catheter complications.
  
  
  METHODS
  Data from the Strategic HealthCare Programs National Database from April 1999 to September 2000 were analyzed. Primary study objectives were to identify (i) types of CVCs and principal diagnoses, (ii) type and rate of catheter complications, and (iii) outcomes in managing thrombotic catheter complications. Event rates were calculated per 1,000 catheter days; 50,470 patients representing 2.83 million catheter days met study criteria.
  
  
  RESULTS
  The rates of complications (per 1,000 catheter days) for the most common events were: catheter dysfunction (0.83 total; 0.6 nonthrombotic, 0.23 thrombotic), catheter site infections (0.26), and bloodstream infections (BSIs; 0.19). A total of 4,138 complication events were identified (event rate per 1,000 days: 1.5). The total rates of complications with each catheter type were: midline catheters (4.5), PICCs (2.0), nontunneled central catheters (1.1), tunneled catheters (1.0), and chest ports (0.52). Catheter dysfunction with loss of patency was the most common group of complications. Thrombotic occlusion was the principal cause of catheter dysfunction, occurring in 28% of patients in this group, typically within 7 days of catheter insertion. BSI was reported in 541 patients, generally more than 30 days after catheter insertion. Catheter thrombosis outcomes resulted in therapy interruption (43%), catheter replacement (29%), premature CVC removal (14%), unscheduled emergency room visits (9%), and/or hospitalizations (6%).
  
  
  CONCLUSIONS
  Catheter dysfunction is the most frequent complication of all CVCs in this population, almost twice that of infections. Outpatient home infusion catheter dysfunction results in delays to therapy, unscheduled hospitalizations, and need for device replacement.
authors.affiliation: PICC Excellence, Orange Park, Florida 32003, USA. nancy.piccexcellence.com
authors.forename: Nancy
authors.initials: N
authors.lastname: Moureau
authors.forename: Susan
authors.initials: S
authors.lastname: Poole
authors.forename: Margie A
authors.initials: MA
authors.lastname: Murdock
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Gray
authors.forename: Charles P
authors.initials: CP
authors.lastname: Semba
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D002408:Catheters, Indwelling / Q000009:adverse effects; D002648:Child; D020878:Device Removal; D004868:Equipment Failure; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology; D018718:Home Infusion Therapy / Q000009:adverse effects; D006801:Humans; D007239:Infections / Q000209:etiology; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D013927:Thrombosis / Q000209:etiology