Multiple roles of calcineurin in skeletal muscle growth.
Adequate muscle mass and function are critical for human health. Several types of skeletal muscle growth, including regeneration and growth after atrophy, can occur in the rehabilitative period after orthopaedic surgery. The molecular pathways regulating growth of skeletal muscle in adults are understood poorly. The role of calcineurin in regulating regeneration and growth of atrophied skeletal muscle is discussed. Understanding the molecular and cellular pathways that regulate such muscle growth may lead to the development of strategies to enhance muscle growth, thereby facilitating rehabilitation after orthopaedic surgery.
Mitchell
Patrick O
PO
Department of Pharmacology, School of Medicine, O.W. Rollins Research Building, Emory University, Atlanta, GA 30322, USA.
Pavlath
Grace K
GK
D000818:Animals; D019703:Calcineurin / Q000502:physiology*; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D019703:Calcineurin