title: Screening with low PSA cutoff values results in low rates of positive surgical margins in radical prostatectomy specimens.
abstract: BACKGROUND
  In the literature, positive margins in radical prostatectomy specimens, the rate of which ranges between 7% and 46%, are associated with adverse patient survival. The aim of the present study was to determine the predictive value of preoperative serum prostate specific antigen (PSA) values for the rate of positive margins in radical retropubic prostatectomy.
  
  
  METHODS
  The study included a cohort of 845 patients who underwent radical retropubic prostatectomy between October of 1993 and December of 1999. All patients were stratified in groups on the basis of their preoperative PSA values: PSA group I, 0-1.99 ng/ml; PSA group II, 2-3.99 ng/ml; PSA group III, 4-5.99 ng/ml; PSA group IV, 6-7.99 ng/ml; PSA group V, 8-9.99 ng/ml; and PSA group VI, >10 ng/ml. For each group, the pathologic stage, Gleason score, and the incidence of positive margins were analyzed. For statistical analysis, the Mann Whitney U-test was used.
  
  
  RESULTS
  Our data show a significantly higher rate of organ-confined prostate cancers and a significantly lower rate of positive surgical margins in patients with preoperative total PSA values of less than 4 ng/ml compared with patients with higher preoperative total PSA levels.
  
  
  CONCLUSIONS
  As tumor stage and surgical margin status after radical prostatectomy are important predictors of the likelihood of PSA recurrence, which necessitates additional therapy, these findings support the concept of PSA screening by using low PSA cutoff levels.
authors.affiliation: Department of Urology, University of Innsbruck, Innsbruck, Austria. andreas.p.berger@uibk.ac.at
authors.forename: Andreas P
authors.initials: AP
authors.lastname: Berger
authors.forename: Hubert
authors.initials: H
authors.lastname: Volgger
authors.forename: Hermann
authors.initials: H
authors.lastname: Rogatsch
authors.forename: Dagmar
authors.initials: D
authors.lastname: Strohmeyer
authors.forename: Hannes
authors.initials: H
authors.lastname: Steiner
authors.forename: Helmut
authors.initials: H
authors.lastname: Klocker
authors.forename: Georg
authors.initials: G
authors.lastname: Bartsch
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Horninger
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D018709:Statistics, Nonparametric
chemical_list: D017430:Prostate-Specific Antigen