title: Involvement of catalase in the endometrium of patients with endometriosis and adenomyosis.
abstract: OBJECTIVE
  To determine the distribution of catalase in eutopic and ectopic endometria in patients with endometriosis or adenomyosis.
  
  
  METHODS
  Retrospective randomized study.
  
  
  METHODS
  Department of obstetrics and gynecology in a university hospital.
  
  
  METHODS
  Thirty-three patients with endometriosis, 36 with adenomyosis, and 47 fertile controls (total, 116 women).
  
  
  METHODS
  Semiquantitative immunostaining of endometrial cells obtained by biopsy sampling, followed by calculation of an evaluation nomogram score.
  
  
  RESULTS
  The score of catalase in the glandular epithelium of controls group fluctuated during the menstrual cycle; it was lowest in the early proliferative phase and peaked in the late secretory phase. In patients with endometriosis, catalase scores did not fluctuate during the cycle, and scores were high compared with controls throughout the menstrual cycle. Catalase scores did not vary in patients with adenomyosis, and scores in this group were consistently higher than those in patients with endometriosis throughout the cycle.
  
  
  CONCLUSIONS
  Abnormal expression of catalase in the eutopic and ectopic endometrium strongly suggests pathologic involvement of free radicals in endometriosis and adenomyosis.
authors.affiliation: Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita-city, Akita-ken, Japan. otah@obgyn.med.akita-u.ac.jp
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ota
authors.forename: Shinichi
authors.initials: S
authors.lastname: Igarashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Sato
authors.forename: Hidenori
authors.initials: H
authors.lastname: Tanaka
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D001706:Biopsy; D002374:Catalase / Q000032:analysis*; D003593:Cytoplasm / Q000201:enzymology; D004715:Endometriosis / Q000201:enzymology*; D004717:Endometrium / Q000201:enzymology*; D004848:Epithelium / Q000201:enzymology; D005260:Female; D005609:Free Radicals; D006801:Humans; D007124:Immunoenzyme Techniques; D008597:Menstrual Cycle; D008875:Middle Aged; D012189:Retrospective Studies; D013194:Staining and Labeling
chemical_list: D005609:Free Radicals; D002374:Catalase