title: Nocturnal oxygen saturation and painful sickle cell crises in children.
abstract: The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory, and sleep study data and frequency of painful crisis was investigated. Both univariate and multiple regression modeling showed that low nocturnal oxygen saturation was highly significantly associated with a higher rate of painful crisis in childhood (P <.0001). Screening and treatment for hypoxemia may reduce the frequency of this and other complications of the disease.
authors.affiliation: Department of Paediatric Epidemiology and Biostatistics, Neurosciences Unit, Institute of Child Health, London, United Kingdom. darren.hargrave@rmh.nthames.nhs.uk
authors.forename: Darren R
authors.initials: DR
authors.lastname: Hargrave
authors.forename: Angie
authors.initials: A
authors.lastname: Wade
authors.forename: Jane P M
authors.initials: JP
authors.lastname: Evans
authors.forename: Deborah K M
authors.initials: DK
authors.lastname: Hewes
authors.forename: Fenella J
authors.initials: FJ
authors.lastname: Kirkham
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D015331:Cohort Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000032:analysis; D010146:Pain / Q000209:etiology*; D012307:Risk Factors; D012890:Sleep
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D010100:Oxygen