[Influence of unilateral nephrectomy on aldosterone receptors in the remaining kidney in rats].
It was shown that the 30th day of compensatory kidney hypertrophy arising as a result of unilateral nephrectomy was accompanied by an increased binding of the mineralocorticoid hormone aldosterone by cytoplasmic receptors of the tubule cells of the remaining kidney. The transfer of aldosterone from cytoplasmic receptors to the nuclear receptors increased in the tubule cells of the hypertrophied kidney. This suggests that at the early stages hypertrophies are expressed as adaptive phenomena and phenomena related to intensified functioning of the organ fulfilling the double load.
Akimov
Iu A
IuA
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul. Butlerova 5A, Moscow, 117485 Russia.
Kosithyn
N S
NS
D000222:Adaptation, Physiological; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D006984:Hypertrophy / Q000378:metabolism; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar
D000450:Aldosterone