title: Gamma knife radiosurgery for metastatic brain tumors.
abstract: We reviewed our series of metastatic brain tumors treated by Gamma Knife Radiosurgery. From May 1992 to January 2001, 115 consecutive patients with 425 lesions were treated over 128 treatment sessions. Forty three patients were known to have died at the end of the recording period. The mean follow-up duration was 11.6 months and mean number of lesions was 3.5. The most common primary sites were lung and breast. Mean tumor volume was 4.2 cm(3) and mean margin dose was 16.2 Gy. 6-month, 1-year, and 18-month survival rates were 73.6, 58, and 46%, respectively. Multivariate analysis revealed that higher KPS scores, no evidence of extracranial metastasis, and controlled primary disease were significantly related to longer survival. Adjuvant whole brain irradiation did not significantly influence on the prolongation of survival time and local control of radiosurgically treated lesions.
authors.affiliation: Department of Neurosurgery and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. ygpark@yumc.yonsei.ac.kr
authors.forename: Y G
authors.initials: YG
authors.lastname: Park
authors.forename: J Y
authors.initials: JY
authors.lastname: Choi
authors.forename: J W
authors.initials: JW
authors.lastname: Chang
authors.forename: S S
authors.initials: SS
authors.lastname: Chung
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000556:secondary; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000556:secondary; D016016:Proportional Hazards Models; D016634:Radiosurgery / Q000379:methods / Q000706:statistics & numerical data; D012189:Retrospective Studies; D015996:Survival Rate