title: Thalamic neuron theory: meridians=DNA. The genetic and embryological basis of traditional Chinese medicine including acupuncture.
abstract: This hypothesis proposes a mechanism by which the genetic information contained in the one-dimensional genome may be converted into a three-dimensional body plan for development. Prior to mitosis of the fertilized egg, the chromatids, after being unpackaged from the chromosomes, link up to form a giant circular loop which is then folded upon itself into a wired-frame structure that embodies the architectural embryological developmental scheme. This intranuclear spatial body design is then translated into a three-dimensional cellar plan surrounding the fertilized egg with the positional value of each surrounding daughter cell preferentially activated by specific spatially oriented gene products diffused through the neatly arranged nuclear pores of the cell nucleus of the fertilized egg. This group of cells of the primitive embryo then leads to the formation of the Spemann Organizer, which directs embryological development of the brain as well as the rest of the body. The Spemann Organizer thus retains control over the CNS which in turn controls the development and functions of the peripheral tissues. The chains of cells that compose the Spemann Organizer, forming a homunculus in the image of the wired frame formed by the chromatids are believed to be the equivalents of acupuncture meridians. To support the hypothesis, evidence is also presented to substantiate the intimate relationships between the acupuncture meridians and embryological development, evolution, the central nervous system as well as the genome. This theoretical model is capable of dispelling the mystery of acupuncture, traditional Chinese medicine and myriads of modern clinical observations, and may have the potential to usher in a multitude of innovative therapeutic methods for many difficult to treat medical conditions.
authors.affiliation: Academy of Pain Research, California, San Francisco 94122, USA.
authors.forename: Tsun-Nin
authors.initials: TN
authors.lastname: Lee
mesh_terms: D026881:Acupuncture; D005075:Biological Evolution; D002877:Chromosomes, Human / Q000235:genetics / Q000502:physiology; D004247:DNA / Q000235:genetics; D004270:DNA, Circular / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics; D004721:Endoplasmic Reticulum / Q000502:physiology; D016332:Fetal Tissue Transplantation; D005801:Genes, Homeobox; D016678:Genome; D006801:Humans; D008516:Medicine, Chinese Traditional; D016740:Meridians; D008938:Mitosis; D008957:Models, Genetic; D008959:Models, Neurological; D022022:Nuclear Pore / Q000502:physiology; D020897:Organizers, Embryonic / Q000502:physiology; D019413:Qi; D013787:Thalamic Nuclei / Q000166:cytology* / Q000502:physiology; D016709:Yin-Yang; D015053:Zygote / Q000648:ultrastructure
chemical_list: D004270:DNA, Circular; D004247:DNA