title: Reading anomalous sentences: an event-related fMRI study of semantic processing.
abstract: We report a random-effects analysis of an event-related fMRI study (n = 28) of cerebral activity during the reading of sentences that ended with a word that was either congruent or incongruent with the previous sentence context. Event-related potential studies have shown that this task elicits a late negativity peaking around 400 ms poststimulus (N400) that is larger for incongruent than for congruent sentence endings. A direct comparison of the activation for incongruent words versus that for congruent words revealed significantly greater activation for incongruent words than congruent words in bilateral inferior frontal and inferio-medial temporal cortex, left lateral frontal cortex, left posterior fusiform gyrus, bilateral motor cortex, and supplementary motor area. These results are consistent with data from intracranial electrical recording studies of the N400 electrical potential. The results are discussed as they relate to the localization of the cerebral sites underlying semantic processing in general and the localization of the scalp recorded N400 event-related potential in particular.
authors.affiliation: Institute of Living at Hartford Hospital, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Kent A
authors.initials: KA
authors.lastname: Kiehl
authors.forename: Kristin R
authors.initials: KR
authors.lastname: Laurens
authors.forename: Peter F
authors.initials: PF
authors.lastname: Liddle
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011897:Random Allocation; D011930:Reaction Time / Q000502:physiology; D011932:Reading