title: [Helicobacter pylori and gastric cancer. The incidence of infection in personal experience].
abstract: BACKGROUND
  Helicobacter pylori is an identified carcinogen for gastric cancer, but the underlying mechanisms remain to be defined. The aim of this study is to analyze the incidence of Hp infection in our series of patients with gastric carcinoma.
  
  
  METHODS
  Between 1988 and 1998, 60 patients with diagnosis of gastric adenocarcinoma underwent partial or total gastrectomy. Forty-one were males and 19 females with an average age of 62 years (range 36-79). Twenty-seven cancers (45%) were localized in the lower third of the stomach, 17 (28%) in the middle third and eight (13%) in the upper third or cardias. In six patients (10%) the tumor was multicentric, while a recurrence on gastric stump after subtotal gastrectomy was present in two cases (3%). According to Lauren's criteria 39 cancers (65%) were of intestinal type, 16 (27%) of diffuse type and five (8%) of mixed type. The histologic preparations have been re-examined in order to verify the presence or not of Hp on gastric mucosa around neoplasm.
  
  
  RESULTS
  Hp was found in 35 (58%) of the analyzed specimens and therefore a significant percentage of patients was Hp-positive at the time of diagnosis and surgery. Between 35 Hp-positive samples, 24 were adenocarcinomas of intestinal type, nine of diffuse type and two of mixed type, with a prevalence of Hp in intestinal type cancer.
  
  
  CONCLUSIONS
  This study confirmed the high incidence of Hp infection in patients with gastric carcinoma, particularly in those with intestinal type cancer.
authors.affiliation: Dipartimento di Chirurgia, Sezione di Chirurgia Generale, Università degli Studi di Catania, Catania, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Caputo
authors.forename: F
authors.initials: F
authors.lastname: Mosca
authors.forename: A
authors.initials: A
authors.lastname: Persi
authors.forename: G
authors.initials: G
authors.lastname: Ettaro
authors.forename: S
authors.initials: S
authors.lastname: Scaringi
authors.forename: G
authors.initials: G
authors.lastname: Russo
authors.forename: D
authors.initials: D
authors.lastname: Piazza
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D001284:Atrophy; D018450:Disease Progression; D005260:Female; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000382:microbiology*; D018530:Gastric Stump; D005756:Gastritis / Q000150:complications* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D007413:Intestinal Mucosa; D007558:Italy / Q000453:epidemiology; D008297:Male; D008679:Metaplasia; D009378:Neoplasms, Multiple Primary; D015995:Prevalence; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000209:etiology* / Q000382:microbiology / Q000601:surgery