title: Impaired lipoprotein metabolism in obese offspring of streptozotocin-induced diabetic rats.
abstract: The time course of changes in lipoprotein metabolism of obese offspring of mildly diabetic rats was studied with respect to serum lipoprotein composition as well as LCAT and tissue lipoprotein lipase (LPL) activities. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, obese pups had higher serum glucose, insulin, and lipoprotein (VLDL, LDL-HDL1, HDL(2-3)) levels than control pups. After 1 mon of life, all of these parameters in obese rats became similar to those of controls. However, LCAT, adipose tissue LPL, and hepatic triacylglycerol lipase activities were high. At 2 mon of age, VLDL-TAG levels were higher in obese females than in controls. By the age of 3 mon, obese offspring had developed insulin resistance with hyperglycemia, hyperinsulinemia, and higher serum lipoprotein concentrations. Indeed, qualitative abnormalities of lipoproteins were seen and were typical of obese and diabetic human beings. Fetal hyperinsulinemia should be considered as a risk factor for later metabolic diseases, including dyslipoproteinemia.
authors.affiliation: Laboratory of Animal Physiology, Tlemcen University, Algeria.
authors.forename: Hafida
authors.initials: H
authors.lastname: Merzouk
authors.forename: Sihem
authors.initials: S
authors.lastname: Madani
authors.forename: Aziz
authors.initials: A
authors.lastname: Hichami
authors.forename: Josiane
authors.initials: J
authors.lastname: Prost
authors.forename: Kabirou
authors.initials: K
authors.lastname: Moutairou
authors.forename: Jacques
authors.initials: J
authors.lastname: Belleville
authors.forename: Naim Akhtar
authors.initials: NA
authors.lastname: Khan
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology; D000818:Animals; D001053:Apolipoproteins / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism*; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced; D006946:Hyperinsulinism / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008049:Lipase / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D013997:Time Factors
chemical_list: D001053:Apolipoproteins; D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins; D002785:Sterol O-Acyltransferase; D008049:Lipase; D008071:Lipoprotein Lipase