title: Pachyclavulariaenones D-G, new diterpenoids from the soft coral Pachyclavularia violacea.
abstract: Four new diterpenoids, pachyclavulariaenones D-G (1-4), have been isolated from the soft coral Pachyclavularia violacea. The structures and relative stereochemistry of metabolites 1-4 were established on the basis of extensive NMR studies and chemical methods. The structure, including the relative configuration of pachyclavulariaenone F (3), was further confirmed by a single-crystal X-ray analysis. Pachyclavulariaenone G (4) has been shown to exhibit significant cytotoxicity toward P-388 and HT-29 cancer cells.
authors.affiliation: Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, Republic of China.
authors.forename: Guey-Horng
authors.initials: GH
authors.lastname: Wang
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes