title: [Antisynthetase syndrome and interstitial lung involvement. Report of 6 cases].
abstract: The cases of 6 patients (4 men, 2 women) with antisynthetase syndrome are reported. The mean age was 60 years and the most frequent symptom was increasing dyspnea (4 patients). One of the remaining 2 patients had hemoptysis and the last was asymptomatic. Systemic symptoms included Raynaud's phenomenon (2 patients), arthritis in hands (3) and muscle impairment (4). Chest films showed linear interstitial infiltrates of varying severity in 5 patients; the patient without such infiltrates also suffered silicosis. Functional assessment showed restrictive impairment in 4 patients; of the remaining 2 patients, 1 had chronic obstructive pulmonary disease and 1 had normal function. The antisynthetase antibody (ASAB) detected was anti-Jo-1 in 4 cases, anti-PL-12 in 1 case, and unidentified in 1 case. The course of disease was satisfactory for 5 patients. ASAB analysis is useful for studying idiopathic interstitial lung disease.
authors.affiliation: Unidad Médico-Quirúrgica de Enfermedades Respiratorias. Hospital Universitario Virgen del Rocío. Sevilla. Spain. rsantiago_villalobos@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Santiago Villalobos
authors.forename: J L
authors.initials: JL
authors.lastname: López-Campos Bodineau
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez Becerra
authors.forename: E
authors.initials: E
authors.lastname: Laserna Martínez
authors.forename: E
authors.initials: E
authors.lastname: Luque Crespo
authors.forename: G
authors.initials: G
authors.lastname: Borja Urbano
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001168:Arthritis / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases; D004417:Dyspnea / Q000276:immunology; D005260:Female; D006801:Humans; D008025:Ligases / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology; D013902:Radiography, Thoracic; D011928:Raynaud Disease / Q000276:immunology; D013577:Syndrome
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C046750:Jo-1 antibody; D008025:Ligases