Antirecoverin antibody in the aqueous humor of a patient with cancer-associated retinopathy.
OBJECTIVE
To describe a patient with cancer-associated retinopathy (CAR) in whom antirecoverin antibody was found in the aqueous humor.


METHODS
Interventional case report.


METHODS
A 65-year-old man underwent resection of adenocarcinoma of the lung in June 1991 and noted deterioration of vision 10 months later. Goldmann perimetry revealed a ring-like scotoma in each eye, and the electroretinogram was nonrecordable. Aqueous humor and peripheral venous blood were collected for Western blot analysis from this patient and three other patients during surgery for age-related cataract.


RESULTS
We found antirecoverin antibody within the aqueous humor and serum in the patient with CAR. In contrast, such imunoreactivities were not observed in specimens from the control patients.


CONCLUSIONS
These observations strongly suggest that antirecoverin antibody penetrates into the aqueous humor and vitreous cavity beyond the blood-retina barrier in CAR.
Ohguro
Hiroshi
H
Department of Ophthalmology, Hirosaki University School of Medicine, Japan. ooguro@cc.hirosaki-u.ac.jp
Maruyama
Ikuyo
I
Nakazawa
Mitsuru
M
Oohira
Akihiko
A
D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D000906:Antibodies / Q000032:analysis* / Q000097:blood; D001082:Aqueous Humor / Q000276:immunology*; D002135:Calcium-Binding Proteins / Q000276:immunology*; D005136:Eye Proteins; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000276:immunology; D051603:Recoverin; D012016:Reference Values; D012162:Retinal Degeneration / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D012607:Scotoma / Q000209:etiology* / Q000503:physiopathology; D014794:Visual Fields
D000906:Antibodies; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin