title: Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.
abstract: Pharmacologic inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine pregnancy results in maternal T-cell-mediated rejection of allogeneic but not syngeneic conceptuses. Increased risk of allogeneic pregnancy failure induced by exposure to IDO inhibitor is strongly correlated with maternal C3 deposition at the maternal-fetal interface. Here we review evidence that cells expressing IDO contribute to immunosuppression by inhibiting T-cell responses to tumor antigens and tissue allografts, as well as fetal tissues.
authors.affiliation: Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA. amellor@mail.mcg.edu
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Mellor
authors.forename: Phillip
authors.initials: P
authors.lastname: Chandler
authors.forename: Geon Kook
authors.initials: GK
authors.lastname: Lee
authors.forename: Theodore
authors.initials: T
authors.lastname: Johnson
authors.forename: Derin B
authors.initials: DB
authors.lastname: Keskin
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Lee
authors.forename: David H
authors.initials: DH
authors.lastname: Munn
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007249:Inflammation / Q000201:enzymology / Q000276:immunology; D008431:Maternal-Fetal Exchange / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D009369:Neoplasms / Q000201:enzymology / Q000276:immunology; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014366:Tryptophan Oxygenase / Q000037:antagonists & inhibitors / Q000276:immunology*
chemical_list: D004791:Enzyme Inhibitors; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D014366:Tryptophan Oxygenase