title: Diagnostic accuracy of EUS in the local staging of primary gastric lymphoma: results of a prospective, multicenter study comparing EUS with histopathologic stage.
abstract: BACKGROUND
  Grade of malignancy and stage of disease are the decisive prognostic factors and therapeutic determinants in primary gastric lymphoma. It is supposed that EUS allows determination of depth of tumor infiltration and perigastric lymph node involvement, thus defining stages I1, I2, and II1. This multicenter study evaluated the accuracy of EUS in the staging of gastric lymphoma.
  
  
  METHODS
  Data from preoperative EUS procedures performed at 34 centers were compared with the histopathologic stage of resection specimens in 80 patients with newly diagnosed primary gastric lymphoma. Ten patients with stage II2 were excluded from analysis because EUS is inappropriate for the evaluation of nonregional lymph node involvement.
  
  
  RESULTS
  EUS correctly classified the lymphoma in 37 of 70 patients (53%). Sensitivity of EUS was as follows: stage I1, 67% (95% CI [38%, 88%]; p = 0.01); stage I2, 83% (95% CI [52%, 98%]; p = 0.01); and stage II1, 71% (95% CI [49%, 87%]; p = 0.02).
  
  
  CONCLUSIONS
  The accuracy of EUS in the local staging of gastric lymphoma has to be improved if nonsurgical treatment strategies based on the grade of malignancy and stage of the disease are to be used. Because most of the participating centers performed EUS in relatively few patients, no conclusion could be drawn with respect to accuracy in relation to EUS experience available at each center or technical considerations with respect to the types of instruments used.
authors.affiliation: Medizinische Klinik II, Kilnikum Aschaffenburg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Fischbach
authors.forename: Maria-Elisabeth
authors.initials: ME
authors.lastname: Goebeler-Kolve
authors.forename: Axel
authors.initials: A
authors.lastname: Greiner
mesh_terms: D000328:Adult; D000368:Aged; D019160:Endosonography; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery