title: CD20-mediated apoptosis: signalling through lipid rafts.
abstract: CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.
authors.affiliation: Immunology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1. jdeans@ucalgary.ca
authors.forename: Julie P
authors.initials: JP
authors.lastname: Deans
authors.forename: Haidong
authors.initials: H
authors.lastname: Li
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Polyak
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018951:Antigens, CD20 / Q000235:genetics / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D006801:Humans; D021962:Membrane Microdomains / Q000276:immunology*; D008969:Molecular Sequence Data; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D018951:Antigens, CD20