title: Chemical and biological weapons. Implications for anaesthesia and intensive care.
abstract: In the wake of recent atrocities there has been renewed apprehension regarding the possibility of chemical and biological weapon (CBW) deployment by terrorists. Despite various international agreements that proscribe their use, certain states continue to develop chemical and biological weapons of mass destruction. Of greater concern, recent historical examples support the prospect that state-independent organizations have the capability to produce such weapons. Indeed, the deliberate deployment of anthrax has claimed several lives in the USA since September 11, 2001. In the event of a significant CBW attack, medical services would be stretched. However, victim survival may be improved by the prompt, coordinated response of military and civil authorities, in conjunction with appropriate medical care. In comparison with most other specialties, anaesthetists have the professional academic background in physiology and pharmacology to be able to understand the nature of the injuries caused by CBWs. Anaesthetists, therefore, play a vital role both in the initial resuscitation of casualties and in their continued treatment in an intensive care setting. This article assesses the current risk of CBW deployment by terrorists, considers factors which would affect the severity of an attack, and discusses the pathophysiology of those CBWs most likely to be used. The specific roles of the anaesthetist and intensivist in treatment are highlighted.
authors.affiliation: Department of Anaesthesia, Guy's and St Thomas' Hospital Trust, St Thomas' Street, London SE1 9RT, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: White
mesh_terms: D000758:Anesthesia / Q000379:methods*; D001408:Bacillus anthracis / Q000472:pathogenicity; D001694:Biological Warfare; D002618:Chemical Warfare; D002619:Chemical Warfare Agents / Q000506:poisoning; D002800:Cholinesterase Inhibitors / Q000506:poisoning; D003422:Critical Care / Q000379:methods*; D003666:Decontamination; D004630:Emergencies; D006801:Humans; D007509:Irritants / Q000506:poisoning; D010705:Phosgene / Q000506:poisoning; D014118:Toxins, Biological / Q000506:poisoning; D014218:Triage; D014780:Viruses / Q000472:pathogenicity; D015010:Yersinia pestis / Q000472:pathogenicity
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D007509:Irritants; D014118:Toxins, Biological; D010705:Phosgene