Macroamylasemia in a patient with multiple myeloma.
We report a rare case of a patient with multiple myeloma who developed hyperamylasemia not associated to hyperamylasuria and without symptoms of pancreatic or salivary disease. This condition suggested the occurrence of macroamylasemia, consisting of macromolecules of amylase bound with immunoglobulins, which are not filtered by the kidneys. Hyperamylasemia was not present at the diagnosis of myeloma and appeared at the relapse of the disease, simultaneously with the appearance of an additional gamma-chain oligoclonal component, suggesting a possible role of these chains in producing macroamylasemia. To our knowledge, this is the first report of macroamylasemia in a patient with multiple myeloma.
Sagristani
Marco
M
Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Italy.
Guariglia
Roberto
R
Pocali
Barbara
B
De Rienzo
Mafalda
M
Guastafierro
Salvatore
S
Romano
Gaetano
G
Tirelli
Angelo
A
D000681:Amylases / Q000097:blood / Q000652:urine; D006801:Humans; D034321:Hyperamylasemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000201:enzymology
D000681:Amylases