title: Kikuchi's disease (histiocytic necrotizing lymphadenitis) with cutaneous involvement.
abstract: We report a case of Kikuchi's disease (histiocytic necrotizing lymphadenitis) in a 22-year-old Japanese man who presented with cervical and axillary lymphadenopathy and who developed edema of lips with desquamation and erosions and transient indurated erythematous papules on the face, neck and upper extremities. A lymph node biopsy specimen showed the typical necrotizing lymphadenitis of Kikuchi's disease. A skin biopsy specimen showed a dense, lymphohistiocytic, superficial, deep perivascular, and interstitial infiltrate, papillary dermal edema, and abundant nuclear debris with a conspicuous absence of neutrophils, paralleling the nodal histology of Kikuchi's disease. CD68 immunohistochemistry showed many plasmacytoid monocytes. Oral corticosteroid (prednisolone 40 mg) therapy improved the skin lesions and other clinical symptoms. Lip involvement by Kikuchi's disease has not been reported, and should be included as one of the possible cutaneous manifestations of Kikuchi's disease.
authors.affiliation: Department of Environmental Immunodermatology, Graduate School, Tokyo Medical and Dental University, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Imai
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yokozeki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nishioka
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001707:Biopsy, Needle; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D008046:Lip / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*; D011379:Prognosis; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome; D034941:Upper Extremity / Q000473:pathology
chemical_list: D011239:Prednisolone