Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6.
OBJECTIVE
Cholesterolemic responses to dietary lipids are known to be heritable, but the genes that may affect this response have yet to be identified. Using segregation analysis, we previously detected a potential quantitative trait locus (QTL) in baboons that influenced low density lipoprotein cholesterol response to dietary cholesterol. We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map.


RESULTS
We obtained evidence for linkage of this potential QTL to the same locus (D6S311) on the baboon homologue of human chromosome 6 by using variance components and parametric linkage analysis methods (2-point lod scores 4.17 [genomic probability value 0.008] and 2.81 [genomic P=0.10], respectively). Linkage analyses of serum levels of apolipoprotein B dietary response, a correlated trait, also gave weak suggestive evidence of linkage to this chromosomal region (maximum 2-point lod score 1.91). Although the LPA locus is nearby, we found no evidence of linkage with LPA.


CONCLUSIONS
This report is the first to localize, in any primate species, a potential QTL that influences low density lipoprotein cholesterol response to dietary cholesterol.
Kammerer
Candace M
CM
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa 15261, USA. ckammerer@hgen.pitt.edu
Rainwater
David L
DL
Cox
Laura A
LA
Schneider
Jennifer L
JL
Mahaney
Michael C
MC
Rogers
Jeffrey
J
VandeBerg
John L
JL
D000818:Animals; D001055:Apolipoproteins B / Q000097:blood / Q000502:physiology; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood / Q000502:physiology*; D002874:Chromosome Mapping / Q000379:methods; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D005809:Genes, Regulator / Q000235:genetics / Q000502:physiology; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics* / Q000502:physiology*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D010215:Papio; D010375:Pedigree; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012689:Sequence Homology, Nucleic Acid
D001055:Apolipoproteins B; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D005819:Genetic Markers