Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.
The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [(211)At]astatide in the UVW human glioma cell line transfected to express NIS. [(211)At]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [(131)I]iodide uptake. These studies suggest [(211)At]astatide as a possible alternative radionuclide to [(131)I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [(211)At]astatide behavior at a cellular level.
Carlin
Sean
S
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA. s.carlin@beatson.gla.ac.uk
Mairs
Robert J
RJ
Welsh
Phil
P
Zalutsky
Michael R
MR
D001246:Astatine / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008713:Methimazole / Q000008:administration & dosage; D010472:Perchlorates / Q000008:administration & dosage; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017670:Sodium Compounds / Q000008:administration & dosage; D027981:Symporters / Q000378:metabolism*; D014162:Transfection; D014407:Tumor Cells, Cultured / Q000378:metabolism; D000099209:Sodium-Iodide Symporters
D001246:Astatine; D007457:Iodine Radioisotopes; D008713:Methimazole; D010472:Perchlorates; D019275:Radiopharmaceuticals; D017670:Sodium Compounds; D027981:Symporters; D000099209:Sodium-Iodide Symporters; C031068:sodium perchlorate