Increased expression of heme oxygenase-1 in human lung transplantation.
Heme oxygenase-1 (HO-1) has been found to be a cytoprotective protein, and has recently been identified as a graft survival gene. This study demonstrates that HO-1 expression is increased in human lung allografts with acute cellular rejection and obliterative bronchiolitis. HO-1 expression was correlated with increased tissue iron and/or ferritin expression and increased inflammatory/oxidant load as measured by myeloperoxidase expression. Although the trigger for increased HO-1 expression in this setting is unknown, it may be related to hemorrhage and/or oxidative stress associated with rejection.
Lu
Fuhua
F
Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA.
Zander
Dani S
DS
Visner
Gary A
GA
D001989:Bronchiolitis Obliterans / Q000201:enzymology*; D005293:Ferritins / Q000378:metabolism; D006084:Graft Rejection / Q000201:enzymology*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D051547:Heme Oxygenase-1; D006801:Humans; D007501:Iron / Q000378:metabolism; D016040:Lung Transplantation / Q000502:physiology*; D008565:Membrane Proteins; D014184:Transplantation, Homologous
D008565:Membrane Proteins; D005293:Ferritins; D007501:Iron; C496541:HMOX1 protein, human; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1