Hydrops foetalis caused by anti-Mur in first pregnancy--a case report.
Anti-'Mia' is the most common alloantibody of potential clinical significance in the Taiwanese population. The Mi.III phenotype is rare among Caucasians but has a high incidence in various Oriental populations. We describe a nulliparous woman with no history of transfusions, who had hydrops foetalis at 28 weeks gestation. Foetal haemoglobin was 4.4 g dL-1, and a positive direct antiglobulin test was positive in the foetal blood. Intrauterine intravascular transfusion was given, and the baby was discharged healthy. Anti-'Mia' was identified in the maternal serum, the cord blood serum and the eluate from red cells of the cord blood. Anti-'Mia' in the maternal serum was confirmed to be anti-Mur. The polymerase chain reaction-restriction fragment length polymorphism method confirmed that both the baby and her father had the Mi.III gene. Therefore, our report documents that anti-Mur has the potential to cause hydrops foetalis.
Wu
K H
KH
China Medical College Hospital, Taichung, Taiwan.
Chang
J G
JG
Lin
M
M
Shih
M C
MC
Lin
H  C
H
Lee
C C
CC
Peng
C T
CT
Tsai
C H
CH
D000017:ABO Blood-Group System / Q000276:immunology; D000328:Adult; D001787:Blood Group Incompatibility; D001788:Blood Grouping and Crossmatching; D001805:Blood Transfusion, Intrauterine; D005190:Family; D005260:Female; D005838:Genotype; D006801:Humans; D015160:Hydrops Fetalis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008951:MNSs Blood-Group System / Q000235:genetics / Q000276:immunology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011296:Prenatal Diagnosis
D000017:ABO Blood-Group System; D007518:Isoantibodies; D008951:MNSs Blood-Group System