The developing synapse: construction and modulation of synaptic structures and circuits.
Synapse formation and stabilization in the vertebrate central nervous system is a dynamic process, requiring bi-directional communication between pre- and postsynaptic partners. Numerous mechanisms coordinate where and when synapses are made in the developing brain. This review discusses cellular and activity-dependent mechanisms that control the development of synaptic connectivity.
Cohen-Cory
Susana
S
Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA. scohenco@ucla.edu
D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D001921:Brain / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure; D002478:Cells, Cultured; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D009414:Nerve Growth Factors / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology / Q000648:ultrastructure; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology; D014795:Visual Pathways
D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter