Detection of Epstein-Barr virus in human colorectal cancer by in situ hybridazition.
OBJECTIVE
To investigate the relationship between Epstein-Barr virus (EBV) and the pathogenesis of human colorectal cancer.


METHODS
The small-molecule RNA fragments of EBV was examined by in situ hybridization in colorectal cancer specimens obtained from 130 patients.


RESULTS
EBV was found in the 6 of 130 colorectal cancer cases. EBV positivity was more prevalent in male patients (4/6), and the tumor tissues of the 4 EBV-positive cases were featured by obvious stromal infiltration by the lymphocytes (4/6).


CONCLUSIONS
EBV infection might be related to the pathogenesis of some colorectal adenocarcinomas in China, and intensive lymphocyte infiltration in the stroma of the tumor tissues can be an important pathological indication of EBV infection in colorectal tumors.
Liu
Huan-Xin
HX
Department of Pathology, First Military Medical University, Guangzhou 510515, China.
Ding
Yan-Qing
YQ
Sun
Ya-Ou
YO
Liang
Li
L
Yang
Yu-Fang
YF
Qi
Zong-Li
ZL
Liu
Ji-Hong
JH
Xiong
Ping-Xia
PX
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis
D012367:RNA, Viral