The Epstein-Barr virus-associated gastric carcinoma in Southern and Northern China.
In the present study, we examined the proportions of Epstein-Barr virus-associated gastric carcinomas (EBV-GCs) in Guangzhou, southern China and Shenyang, northern China, two areas differing markedly in nasopharyngeal carcinoma (NPC) incidence. Using in situ hybridization assay, the presence of EBV-encoded small RNA (EBER) was examined in 198, and 180 gastric cancer cases in Guangzhou and Shenyang, respectively. The proportion of EBV-GC in Guangzhou (9%) was significantly higher than that in Shenyang (6%), and the odds ratio (OR) for Guangzhou, after adjusting for the effects of age, sex, and tumor subsite, was 2.7 (95% CI = 1.1-6.2) when Shenyang was taken as reference. There was a male predominance of EBV-GC, and the OR for male was 3.0 (95% CI = 1.2-7.3) when female was taken as reference. We observed a weak and negative age dependence in the proportion of EBV-GC (p-values for trend = 0.077). The EBV-GC was most commonly observed in the middle part of stomach in both series. The frequency of EBV-GCs was higher in cases with p53 overexpression than in cases without p53 expression (OR = 2.4, 95% CI = 1.0-5.8). Among p53-positive cases, the frequency of EBV-GC decreased as the proportion of p53-positive carcinoma cells increased (p for trend = 0.021). In conclusion, the present study suggested that the frequency of EBV-GC in Guangzhou, southern China, where NPC is the most common in the world, may be higher than that in other parts of China.
Hao
Zhuofang
Z
Department of Pathology, the Second Affiliated Hospital, Guangzhou Medical College, Haizhu District, Guagngzhou 510260, GD, Guangdong, P.R. China.
Koriyama
Chihaya
C
Akiba
Suminori
S
Li
Jing
J
Luo
Xinming
X
Itoh
Tetsuhiko
T
Eizuru
Yoshito
Y
Zou
Jianming
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D005260:Female; D015870:Gene Expression; D004854:Herpesvirus 4, Human / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D015345:Oligonucleotide Probes; D011379:Prognosis; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D016159:Tumor Suppressor Protein p53 / Q000276:immunology / Q000378:metabolism
C099537:Epstein-Barr virus encoded RNA 1; D015345:Oligonucleotide Probes; D012367:RNA, Viral; D016159:Tumor Suppressor Protein p53