Effect of continuous ATP injection on human hemodynamics.
Continuous ATP injection is used clinically for Tl imaging or coronary flow measurement and because the effect on human hemodynamics is unknown, the present study investigated it in 14 patients undergoing heart catheter examination. Continuous ATP injection induced chest symptoms in 13 of the patients and second-degree atrioventricular block in one, but these complications disappeared immediately after the end of ATP infusion. Continuous ATP injection decreased aortic pressure, but increased pulmonary artery pressure, right atrial pressure and pulmonary capillary wedge pressure. ATP increased heart rate, stroke volume and cardiac output, the latter the result of an increase in preload, a decrease in afterload, and the increase in heart rate.
Komukai
Kimiaki
K
Department of Internal Medicine, The Jikei University School of Medicine, Tokyo Japan. komu@jikei.ac.jp
Hashimoto
Koichi
K
Shibata
Takahiro
T
Iwano
Keiji
K
Muto
Makoto
M
Mogi
Junichi
J
Imai
Kamon
K
Horie
Toshinobu
T
Mochizuki
Seibu
S
D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity; D000368:Aged; D002637:Chest Pain / Q000139:chemically induced; D004562:Electrocardiography; D005260:Female; D006261:Headache / Q000139:chemically induced; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D008297:Male; D008722:Methods; D008875:Middle Aged; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity
D014665:Vasodilator Agents; D000255:Adenosine Triphosphate; D000241:Adenosine