Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers.
Two injections of tetravalent (Groups A, C, Y and W-135) meningococcal polysaccharide vaccine conjugated to diphtheria were given to 30 toddlers at dosages of 1, 4 and 10 microg/ml polysaccharide of each serogroup. Reactogenicity was acceptable at all dosages. The 4-microg/ml dose appears to be immunologically optimal.
Rennels
Margaret
M
Center for Vaccine Development and Department of Pediatrics University of Maryland School of Medicine Baltimore, MD, USA.
King
James
J
Ryall
Robert
R
Manoff
Susan
S
Papa
Thomas
T
Weddle
Andrea
A
Froeschle
James
J
D000942:Antigens, Bacterial / Q000032:analysis*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007115:Immunization Schedule; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage*; D011135:Polysaccharides, Bacterial; D012449:Safety; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods*; D018074:Vaccines, Conjugate
D000942:Antigens, Bacterial; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate