title: A comparison of normal tissue complication probability of brain for proton and photon therapy of canine nasal tumors.
abstract: This study compared the calculated normal tissue complication probability of brain in dogs with a nasal tumor, which had both photon and proton treatment planning. Nine dogs diagnosed with a variety of histologies, but all with large, caudally located nasal tumors were studied. Three-dimensional (3-D) photon dose distribution, and a proton dose distribution was calculated for each dog. To calculate the normal tissue complication probability (NTCP) for brain, the partial brain volume irradiated with the prescribed dose was determined, then a mathematic model relating complications to partial volume and radiation dose was used. The NTCP was always smaller for proton plans as compared to photon plans, indicating conformation of the dose to the target allows a higher dose to be given. If a 5% NTCP were accepted, the mean applicable dose for this group of dogs was 50.2 Gy for photons, but 58.3 Gy for protons. Not all dogs would benefit the same from proton irradiation. If a large partial brain volume has to be irradiated, the advantage becomes minimal. There is also a minimal advantage if the planning target volume (PTV) includes a small, superficial brain volume. However, for a complex PTV shape the degree of conformation is clearly superior for protons and results in smaller calculated NTCPs.
authors.affiliation: Section of Diagnostic Imaging and Radio-Oncology, Veterinary School, University of Zurich, Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kaser-Hotz
authors.forename: Andrea
authors.initials: A
authors.lastname: Sumova
authors.forename: Antony
authors.initials: A
authors.lastname: Lomax
authors.forename: Uwe
authors.initials: U
authors.lastname: Schneider
authors.forename: Bettina
authors.initials: B
authors.lastname: Klink
authors.forename: Janean
authors.initials: J
authors.lastname: Fidel
authors.forename: Hans
authors.initials: H
authors.lastname: Blattmann
mesh_terms: D000818:Animals; D016371:Cranial Irradiation / Q000009:adverse effects / Q000662:veterinary*; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008297:Male; D009669:Nose Neoplasms / Q000532:radiotherapy / Q000662:veterinary*; D011522:Protons / Q000009:adverse effects*; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000662:veterinary
chemical_list: D011522:Protons