title: Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora.
abstract: Seven stilbenes, a new cis-epsilon-viniferin and the six known stilbenes, trans-resveratrol, trans-resveratrol-4'-O-beta-D-glucopyranoside, trans-epsilon-viniferin, gnetin H, and suffruticosol A and B, were isolated and identified from seeds of Paeonia lactiflora. The antioxidative activity of these stilbene derivatives was evaluated against the 2-deoxyribose degradation and rat liver microsomal lipid peroxidation induced by the hydroxyl radical generated via a Fenton-type reaction. Among these stilbenes, trans-epsilon-viniferin and gnetin H significantly inhibited 2-deoxyribose degradation and lipid peroxidation in rat liver microsomes. In addition, cis-epsilon-viniferin, and suffruticosol A and B also exhibited moderate antioxidative activity. These results suggest that resveratrol dimers and trimers, together with resveratrol from seeds of Paeonia lactiflora may be useful as potential sources of natural antioxidants.
authors.affiliation: Department of Food Science and Nutrition, Catholic University of Daegu, Hayang, Gyeongbuk, Korea
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Chang
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Cho
authors.forename: Shin Kyo
authors.initials: SK
authors.lastname: Chung
authors.forename: Heui Dong
authors.initials: HD
authors.lastname: Park
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Choi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D003855:Deoxyribose / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D029596:Paeonia / Q000737:chemistry*; D051381:Rats; D000077185:Resveratrol; D012639:Seeds / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D017665:Hydroxyl Radical; D003855:Deoxyribose; D000077185:Resveratrol