title: A case of paroxysmal kinesigenic dyskinesia with spastic paraparesis.
abstract: We report the first case of paroxysmal kinesigenic dyskinesia (PKD) with spastic paraparesis. A 17-year-old male began to show a dystonic posture in both his upper limbs when walking at age 12 years. Neurological examination revealed bilateral talipes cavus, spasticity in all extremities with general hyperreflexia and pathological reflexes. On starting to walk, he showed a dystonic posture in bilateral maniphalanx, wrists, elbows, and toes. Magnetic resonance imaging (MRI) revealed high T2-weighted signal intensity in bilateral pyramidal tract. Although the combination of pyramidal and the basal ganglia disorders is very rare, the present case suggests an inter-relation of the pyramidal and the basal ganglia systems.
authors.affiliation: Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Manabe
authors.forename: C
authors.initials: C
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Shiote
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Shoji
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology*; D002220:Carbamazepine / Q000627:therapeutic use; D002819:Chorea / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004576:Electromyography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D020336:Paraparesis, Spastic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D011712:Pyramidal Tracts / Q000473:pathology / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine