title: Daphnane-type diterpene orthoesters and their biological activities.
abstract: Daphnane orthoesters are the active ingredients of plant remedies from the Western, Chinese and African traditional medicine, and have provided important tools to investigate medicinally relevant processes like tumour promotion, apoptosis, neurotrophism, and VR1 activation. The occurrence, biological activity, and molecular pharmacology of these compounds will be reviewed.
authors.affiliation: Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, B-9000, Belgium. norbert.dekimpe@rug.ac.be
authors.forename: Weidong
authors.initials: W
authors.lastname: He
authors.forename: Miroslav
authors.initials: M
authors.lastname: Cik
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Luc Van
authors.initials: LV
authors.lastname: Puyvelde
authors.forename: Josée E
authors.initials: JE
authors.lastname: Leysen
authors.forename: Norbert
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D004952:Esters / Q000494:pharmacology; D006801:Humans; D008519:Medicine, Traditional; D010946:Plants, Medicinal / Q000737:chemistry*; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D004952:Esters; D013729:Terpenes; C011309:mezerein