Role of mitochondrial dysfunction in Alzheimer's disease.
Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.
Castellani
Rudy
R
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. rjc8@po.cwru.edu
Hirai
Keisuke
K
Aliev
Gjumrakch
G
Drew
Kelly L
KL
Nunomura
Akihiko
A
Takeda
Atsushi
A
Cash
Adam D
AD
Obrenovich
Mark E
ME
Perry
George
G
Smith
Mark A
MA
D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003580:Cytochromes / Q000172:deficiency / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D028361:Mitochondrial Diseases / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*
D003580:Cytochromes; D004272:DNA, Mitochondrial