title: Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans.
abstract: Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.
authors.affiliation: Department of Gastroenterology, University Medical Center Nijmegen, Nijmegen, The Netherlands. G.Wanten@gastro.azn.nl
authors.forename: Geert J
authors.initials: GJ
authors.lastname: Wanten
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: Ton H
authors.initials: TH
authors.lastname: Naber
authors.forename: Jo H
authors.initials: JH
authors.lastname: Curfs
authors.forename: Liesbeth E
authors.initials: LE
authors.lastname: Jacobs
authors.forename: Trees J
authors.initials: TJ
authors.lastname: Verver-Jansen
authors.forename: Bart-Jan
authors.initials: BJ
authors.lastname: Kullberg
mesh_terms: D002176:Candida albicans / Q000254:growth & development; D002177:Candidiasis / Q000209:etiology*; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007371:Interferon-gamma / Q000096:biosynthesis; D009504:Neutrophils / Q000276:immunology; D014280:Triglycerides / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D007371:Interferon-gamma