title: A matched case-control study on the prognosis of native kidney neoplasia in renal transplant recipients.
abstract: A matched case-control study was performed to compare the prognosis of six renal transplant recipients with a control group of non-transplant patients, both groups presenting with native kidney tumors. Patients were matched for age, gender, neoplasm histology, and TNM classification. The follow-up ranged from 8 to 131 months (median 32 months) after nephrectomy or nephroureterectomy of the native kidney. Five out of six recipients retained good graft function. No evidence of recurrent local disease or distant metastasis of kidney neoplasms was observed in either group. In the transplant group, two patients developed basal cell carcinoma, and one, lung cancer and a disseminated lymphoma. Among control group patients, prostate and bladder cancer were noted. Prognosis of early-stage kidney malignancy in the transplant and non-transplant group was comparable despite immunosuppression; however, recovery from the primary kidney malignancy did not exclude the risk of developing a new type of neoplasm in either group.
authors.affiliation: Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Banacha 1a, Poland. trgroch@amwaw.edu.pl
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Grochowiecki
authors.forename: Jacek
authors.initials: J
authors.lastname: Szmidt
authors.forename: Slawomir
authors.initials: S
authors.lastname: Nazarewski
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Galazka
authors.forename: Magdalena
authors.initials: M
authors.lastname: Durlik
authors.forename: Tomasz
authors.initials: T
authors.lastname: Borkowski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Borkowski
authors.forename: Mikolaj
authors.initials: M
authors.lastname: Wojtaszek
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009392:Nephrectomy; D011183:Postoperative Complications / Q000453:epidemiology; D011379:Prognosis; D013997:Time Factors