title: [The expression of p53 and c-erb-2 in transitional cell carcinoma of the kidney pelvis and ureter and its relation to tumor progression and survival].
abstract: OBJECTIVE
  To evaluate P 53 and c-erb-2 overexpression as a prognostic factor for progression and survival in patients with renal pelvis and ureter tumors.
  
  
  METHODS
  Retrospective review of the medical records and pathology/immunohistochemical reports of 61 patients who underwent surgery for upper urinary tract urothelial tumors. Immunohistochemical studies were performed using the STREPTAVIDIN-BIOTIN-PEROXIDASE techniques with a LASAB kit (DAKO). Pearson's Chi square for 2 x 2 contingency tables and residues analysis were used for non continuous variables, with a confidence level of p < 0.05. COX multivariate analysis and survival curves were used for multiple variables association.
  
  
  RESULTS
  A higher P 53 overexpression was related with tumour dependent death (p < 0.001). These patients have their long term survival compromised. C-erb-2 overexpression is not statistically related to either proliferation or cancer specific death in upper urinary tract urothelial tumors.
  
  
  CONCLUSIONS
  In our series P53 overexpression has prognostic value in upper urinary tract urothelial tumors, but c-erb-2 did has not prognostic value.
authors.affiliation: Servicio de Urología y Servicio de Anatomía Patológica, Hospital General Universitario de Murcia, España.
authors.forename: Luis Oscar
authors.initials: LO
authors.lastname: Fontana
authors.forename: Felipe
authors.initials: F
authors.lastname: García García
authors.forename: Isabel
authors.initials: I
authors.lastname: Arcas Martínez Salas
authors.forename: Julián
authors.initials: J
authors.lastname: García Ligero
authors.forename: Mariano
authors.initials: M
authors.lastname: Tomás Ros
authors.forename: José Luis
authors.initials: JL
authors.lastname: Rico Galiano
authors.forename: Andrés
authors.initials: A
authors.lastname: Sempere Gutiérrez
authors.forename: Manuel
authors.initials: M
authors.lastname: Canteras Jordana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018734:Genes, erbB-2; D016158:Genes, p53; D006801:Humans; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D007682:Kidney Pelvis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D012189:Retrospective Studies; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D014516:Ureteral Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53