title: Enantioselective alkylation of aldehydes with chiral organomagnesium amides (COMAs).
abstract: [reaction: see text] Dialkylmagnesiums react with chiral secondary amines to form chiral organomagnesium amides (COMAs). These reagents alkylate aldehydes to form secondary alcohols with enantioselectivities up to 91:9 er.
authors.affiliation: Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, (GWC)(2), and Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Kelvin H
authors.initials: KH
authors.lastname: Yong
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Taylor
authors.forename: J Michael
authors.initials: JM
authors.lastname: Chong