[ENT inflammation and importance of fenspiride].
PERSISTENT INFLAMMATION: Inflammation may persist despite the eviction of the aggressive agent because of the disruption of the regulator mechanisms. In such patients, drugs such as fenspiride can be effective at several levels, from onset of inflammation, in an attempt to control its progression. INHIBITION OF NEUROPHIL MIGRATION: Could be a very interesting propriety for controlling inflammation of the human respiratory mucosa. CONTROL OF FREE RADICALS: In certain cases, clearance of free oxygen radicals by cells implicated in the inflammatory process may be overrun. Fenespiride can limit the production of free radicals, probably at the level of the producing cells. ACTION ON THE ARACHIDONIC ACID CASCADE: The mechanism and site of action of fenspiride remains to be clarified. It does not act like conventional antiinflammatory drugs by inhibiting cyclo-oxygenase. ANTIHISTAMINE ACTIVITY: Fenspiride has a certain antihistamine activity, basically by blocking H1 receptors. This action should be tested in subjects with nonspecific nasal hyperreactivity. OTHER PROPERTIES: Fenspiride also has an alpha-1-adrenolytic activity and an inhibitor effect on cyclic AMP, two properties which could have an impact on inflammatory diseases of the upper airways.
Jankowski
R
R
Service d'ORL et de chirurgie cervico-faciale, CHU-Hôpital Central F-54035 Nancy.
D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects / Q000276:immunology; D002908:Chronic Disease; D000242:Cyclic AMP / Q000037:antagonists & inhibitors; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy* / Q000276:immunology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013141:Spiro Compounds / Q000009:adverse effects / Q000627:therapeutic use*
D006634:Histamine H1 Antagonists; D011942:Receptors, Adrenergic, alpha; D013141:Spiro Compounds; D016718:Arachidonic Acid; D000242:Cyclic AMP; C084775:fenspiride