title: Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8; 21), 5q-, -Y karyotype.
abstract: A 31 -year-old man was admitted to hospital with onset of difficulty in walking and urinary incontinence, leading to the diagnosis of Langerhans cell histiocytosis (LCH) which was replacing a thoracic vertebra. Four months after the completion of radiation therapy, he was referred to our department with persistent fever and severe pyogenic ulceration mainly affecting the right-hip. A diagnosis of acute non-lymphoblastic leukemia (ANLL) was made. Cytogenetic studies showed 45,X, t(8; 21), 5q-, -Y We report this case because, development of acute leukemia after LCH is rare and the literature searched for any cytogenetic study in these kind of cases yielded no data.
authors.affiliation: Department of Hematology, Osmangazi University, Medical School, Eskisehir, Turkey.
authors.forename: Vahap
authors.initials: V
authors.lastname: Aslan
authors.forename: O Meltem
authors.initials: OM
authors.lastname: Akay
authors.forename: Beyhan
authors.initials: B
authors.lastname: Durak
authors.forename: Sare
authors.initials: S
authors.lastname: Kabukcuoglu
authors.forename: Zafer
authors.initials: Z
authors.lastname: Gulbas
mesh_terms: D000328:Adult; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D008297:Male; D014178:Translocation, Genetic