[Recurrent idiopathic stupor in a patient: responsibility of exogenous or endogenous benzodiazepines?].
Recurrent transitory consciousness loss represents a neurological diagnostic difficulty. A 56 year old man was hospitalised for recurrent stupor episodes. Explorations allowed to exclude hepatic, renal or respiratory failures, epilepsy or sleep disorder. During a stuporous state, since the patient was clearly awakened by flumazenil administration, the retained diagnosis was idiopathic recurrent stupor, a rare and not well-known disease. The authors discuss the possible effect of a treatment with zolpidem, though its pharmacokinetic characteristics did not correspond to the patient manifestations, and the possible responsibility of endogenous benzodiazepines in the genesis of this trouble.
Huberfeld
G
G
Service de Neurologie 1 (AP-HP), Hôpital de la Salpêtrière, Paris, France.
Dupont
S
S
Hazemann
P
P
Adam
C
C
Baulac
M
M
Pierrot-Deseilligny
C
C
D001569:Benzodiazepines / Q000009:adverse effects* / Q000378:metabolism*; D003128:Coma / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism*; D005442:Flumazenil / Q000627:therapeutic use; D018757:GABA Modulators / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D012008:Recurrence
D018757:GABA Modulators; D001569:Benzodiazepines; D005442:Flumazenil