title: Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.
abstract: Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Rao
authors.forename: Anna
authors.initials: A
authors.lastname: Carbone
authors.forename: Alba
authors.initials: A
authors.lastname: Chimirri
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Monforte
authors.forename: Pietro
authors.initials: P
authors.lastname: Monforte
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
authors.forename: Maria
authors.initials: M
authors.lastname: Zappalà
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D013830:Thiadiazoles