title: Co-occurrence of neuroblastoma and nephroblastoma in an infant with Fanconi's anemia.
abstract: We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But untypical genetic changes were also seen suggesting that FA as a chromosomal instability syndrome causes new and untypical chromosomal variations in different tumors. The present case is unique because the simultaneous occurrence of a neuroblastoma and nephroblastoma with FA has not yet been described.
authors.affiliation: Division of Hematology/Oncology, University Children's Hospital Basel, Basel, Switzerland.
authors.forename: Heidi
authors.initials: H
authors.lastname: Bissig
authors.forename: Franziska
authors.initials: F
authors.lastname: Staehelin
authors.forename: Markus
authors.initials: M
authors.lastname: Tolnay
authors.forename: Pierino
authors.initials: P
authors.lastname: Avoledo
authors.forename: Jan
authors.initials: J
authors.lastname: Richter
authors.forename: David
authors.initials: D
authors.lastname: Betts
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bruder
authors.forename: Thomas
authors.initials: T
authors.lastname: Kühne
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology; D002886:Chromosomes, Human, Pair 17; D005199:Fanconi Anemia / Q000150:complications* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology; D009447:Neuroblastoma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D009396:Wilms Tumor / Q000150:complications* / Q000235:genetics / Q000473:pathology