Biomimetic reduction of nimesulide with NaBH4 catalyzed by metalloporphyrins.
The biomimetic reduction of anti-inflammatory drug, nimesulide (1) with sodium borohydride catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides [TAPFe(III)Cl] has been studied in organic solvents under anaerobic and aerobic conditions.
Chauhan
Shive Murat Singh
SM
Department of Chemistry, University of Delhi, India. smschauhan@chemistry.du.ac.in
Kandadai
Srinivas Appan
SA
Kumar
Anil
A
D032701:Biomimetics / Q000379:methods*; D001894:Borohydrides / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis / Q000187:drug effects; D008665:Metalloporphyrins / Q000737:chemistry / Q000378:metabolism*; D013449:Sulfonamides / Q000737:chemistry / Q000378:metabolism*
D001894:Borohydrides; D008665:Metalloporphyrins; D013449:Sulfonamides; C025364:sodium borohydride; C012655:nimesulide