title: Component of Zingiber officinale that improves the enhancement of small intestinal transport.
abstract: 6-Shogaol, a constituent of Zingiber officinale, improved carbachol-induced accelerated small intestinal transit in vivo, as well as improving longitudinal muscle contraction induced by low-frequency electrical stimulation of the isolated guinea pig small intestine in vitro. In addition, 6-shogaol ameliorated BaCl(2) -induced hyperperistalsis of the small intestine in vivo.
authors.affiliation: Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ami-machi, Ibaraki 300-1192, Japan. hashimoto_kazunori@mail.tsumura.co.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Kazuko
authors.initials: K
authors.lastname: Satoh
authors.forename: Pin
authors.initials: P
authors.lastname: Murata
authors.forename: Bunsho
authors.initials: B
authors.lastname: Makino
authors.forename: Iwao
authors.initials: I
authors.lastname: Sakakibara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kase
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishige
authors.forename: Masami
authors.initials: M
authors.lastname: Higuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D017609:Barium Compounds; D002396:Catechols / Q000008:administration & dosage / Q000494:pharmacology*; D002712:Chlorides; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000187:drug effects*; D020939:Zingiber officinale; D006168:Guinea Pigs; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects*; D008517:Phytotherapy; D018517:Plant Roots
chemical_list: D017609:Barium Compounds; D002396:Catechols; D002712:Chlorides; C024986:barium chloride; C040115:shogaol