title: Decompressive surgery in the treatment of traumatic brain injury.
abstract: According to European Brain Injury Consortium (EBIC) and American Brain Injury Consortium (ABIC) guidelines for severe head injuries, decompressive craniectomy is one therapeutic option for brain edema that does not respond to conventional therapeutic measures. As a result of the failure of all recently developed drugs to improve outcome in this patient group, decompressive craniectomy has experienced a revival during the last decade. Although class I studies of this subject are still lacking, there is strong evidence from prospective, uncontrolled trials that such an operation improves outcome in general and also has beneficial effects on various physiologic parameters that are known to be independent predictors for poor outcome. Whether this operation should be performed in a protocol-driven or in a prophylactic manner remains unclear. Decompressive craniectomy may, however, be the only method available in developing countries with limited ICU and monitoring resources. Prospectively controlled and randomized studies to definitively evaluate the effect of this old neurosurgical method on outcome in patients with traumatic brain injury (TBI) are forthcoming.
authors.affiliation: Neurosurgical Clinic, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. piek-jue@uni-greifswald.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Piek
mesh_terms: D001929:Brain Edema / Q000601:surgery*; D001930:Brain Injuries / Q000601:surgery*; D003399:Craniotomy / Q000009:adverse effects / Q000379:methods; D019299:Decompression, Surgical / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007427:Intracranial Pressure; D016896:Treatment Outcome