title: Detection of hyperoxaemia in neonates: data from three new pulse oximeters.
abstract: OBJECTIVE
  To determine the sensitivity and specificity of three newly developed pulse oximeters in the detection of hyperoxaemia, defined as an arterial partial pressure of oxygen (PaO(2)) of > 80 mm Hg.
  
  
  METHODS
  SpO(2) readings from three oximeters (Agilent Viridia (AgV), Masimo SET (MaS), Nellcor Oxismart (NeO)) were documented in 56 infants (median gestational age at birth 35.5 weeks, range 24-41) whenever an arterial blood gas was taken for clinical purposes. Blood samples were analysed within one minute in a Radiometer ABL 505 blood gas analyser and OSM3 co-oximeter.
  
  
  RESULTS
  Between 280 and 291 blood gases were analysed for each instrument; 105-112 showed a PaO(2) > 80 mm Hg. At an upper alarm limit of 95%, the three instruments detected hyperoxaemia with 93-95% sensitivity. Specificity at this alarm level ranged from 26 to 45%. The mean (SD) difference between arterial oxygen saturation and SpO(2) (bias) was -0.25 (2.5)% for AgV, -0.06 (2.5)% for MaS, and -0.91 (2.6)% for NeO (p < 0.01, NeO v AgV and MaS).
  
  
  CONCLUSIONS
  These instruments detected hyperoxaemia with sufficient sensitivity at an upper alarm limit of 95%, but showed differences in their specificity, which was probably related to differences in measurement bias.
authors.affiliation: Department of Neonatology and Pediatric Pulmonology, Hannover Medical School, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Bohnhorst
authors.forename: C S
authors.initials: CS
authors.lastname: Peter
authors.forename: C F
authors.initials: CF
authors.lastname: Poets
mesh_terms: D005260:Female; D005865:Gestational Age; D006801:Humans; D018496:Hyperoxia / Q000175:diagnosis*; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D008297:Male; D010092:Oximetry / Q000295:instrumentation* / Q000592:standards; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012680:Sensitivity and Specificity
chemical_list: D010100:Oxygen