title: Treatment of experimental nephrosis by culture filtrate of Cryptococcus neoformans var. gattii (CneF).
abstract: The therapeutic effect of the culture filtrate of cryptococcus neoformans var. gattii (CneF) was tested in Adriamycin-induced nephropathy. The CneF was administered at different doses (36, 54 and 90 mg/kg based on carbohydrate concentration), one i.p. injection every 72 hours for a total of 10 injections. The treated patient rats showed a significant reduction in proteinuria, plasma cholesterol concentration, BUN and significant increase in urine creatinine levels. Moreover, treatment with CneF significantly reduced number of glomerular leukocytes and decreased the tubular casts. These data suggest that CneF therapy can ameliorate proteinuria, hypercholesterolemia and suppress the progression of glomerular lesions in experimental model of nephrosis.
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Iran. mirshafiey_tums_edu_ir@yahoo.com
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
authors.forename: Alireza
authors.initials: A
authors.lastname: Razavi
authors.forename: Farhad
authors.initials: F
authors.lastname: Mehrabian
authors.forename: Mohammad R Nikouei
authors.initials: MR
authors.lastname: Moghaddam
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Hadjavi
mesh_terms: D000818:Animals; D000946:Antigens, Fungal / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003455:Cryptococcus neoformans / Q000276:immunology*; D005260:Female; D005374:Filtration; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011134:Polysaccharides / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000946:Antigens, Fungal; D007166:Immunosuppressive Agents; D011134:Polysaccharides; C027478:glucuronoxylomannan; D002784:Cholesterol