title: Detection of Epstein-Barr virus in human colorectal cancer by in situ hybridazition.
abstract: OBJECTIVE
  To investigate the relationship between Epstein-Barr virus (EBV) and the pathogenesis of human colorectal cancer.
  
  
  METHODS
  The small-molecule RNA fragments of EBV was examined by in situ hybridization in colorectal cancer specimens obtained from 130 patients.
  
  
  RESULTS
  EBV was found in the 6 of 130 colorectal cancer cases. EBV positivity was more prevalent in male patients (4/6), and the tumor tissues of the 4 EBV-positive cases were featured by obvious stromal infiltration by the lymphocytes (4/6).
  
  
  CONCLUSIONS
  EBV infection might be related to the pathogenesis of some colorectal adenocarcinomas in China, and intensive lymphocyte infiltration in the stroma of the tumor tissues can be an important pathological indication of EBV infection in colorectal tumors.
authors.affiliation: Department of Pathology, First Military Medical University, Guangzhou 510515, China.
authors.forename: Huan-Xin
authors.initials: HX
authors.lastname: Liu
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Ding
authors.forename: Ya-Ou
authors.initials: YO
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Yang
authors.forename: Zong-Li
authors.initials: ZL
authors.lastname: Qi
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Liu
authors.forename: Ping-Xia
authors.initials: PX
authors.lastname: Xiong
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis
chemical_list: D012367:RNA, Viral