Visualization of microvascularity in glioblastoma multiforme with 8-T high-spatial-resolution MR imaging.
We used 8-T high-spatial-resolution gradient-echo MR imaging to directly visualize microvascularity in pathologically proved glioblastoma multiforme. Images were compared with 1.5-T high-spatial-resolution fast spin-echo T2-weighted images and digital subtraction angiograms. Preliminary data indicate that 8-T high-spatial-resolution MR imaging may enable the identification of areas of abnormal microvascularity in glioblastoma multiforme that are not visible with other routine clinical techniques.
Christoforidis
Gregory A
GA
Department of Radiology, the Ohio State University Medical Center, 168 Means Hall, 1654 Upham Drive, Columbus, OH 43221, USA.
Grecula
John C
JC
Newton
Herbert B
HB
Kangarlu
Allahyar
A
Abduljalil
Amir M
AM
Schmalbrock
Petra
P
Chakeres
Donald W
DW
D000328:Adult; D015901:Angiography, Digital Subtraction; D001932:Brain Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005909:Glioblastoma / Q000098:blood supply* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000000981:diagnostic imaging