Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats.
OBJECTIVE
To investigate the changes of gastrin, somatostatin and motilin production in the gastric antral mucosa of rats with experimental gastric ulcer.


METHODS
Rat models of gastric ulcer model were induced successfully by injection of acetic acid into the gastric antral wall of 2 groups of Wistar rats (7 in each group) that were subjected to environment of either high or normal temperature. Another 2 groups of rats (n=7) receiving normal saline injection in the same manner, along with still another 2 groups (n=7) without any treatment, all of which were kept under conditions with different temperatures accordingly, constituted the control groups. The levels of gastrin, somatostatin and motilin in the gastric antral mucosa of the rats were measured with radioimmunoassay.


RESULTS
In rats with gastric ulcer, the levels of gastrin and motilin in the antral mucosa increased, but in a lesser scale in rats with ulcer kept in high temperature than in normal temperature group, while that of somatostatin was reduced. The level of somatostatin declined less in the high temperature group with ulcer than in the normal temperature group with ulcer.


CONCLUSIONS
High temperature can affect gastrin, somatostatin and motilin production in the gastric antral mucosa of rats with gastric ulcer.
Sun
Feng-Peng
FP
Department of Gastroenterology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. sun@fimmu.com
Dan
Han-Lei
HL
Song
Yu-Gang
YG
Cheng
Wei
W
D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D008297:Male; D009037:Motilin / Q000378:metabolism*; D011706:Pyloric Antrum / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism*; D013276:Stomach Ulcer / Q000378:metabolism*; D013696:Temperature
D005755:Gastrins; D013004:Somatostatin; D009037:Motilin