title: Endometrial carcinoma cells are nonpermissive for CD44-erbB2 interactions.
abstract: The erbB2 receptor tyrosine kinase and the CD44 transmembrane glycoprotein interact with one another in numerous cell types. This interaction helps to maintain erbB2 activity that contributes to tumor progression. We investigated whether CD44 and erbB2 similarly interact in endometrial carcinomas in vitro and in situ. In contrast to other carcinomas, CD44 did not colocalize with erbB2 in any of the 51 cases of endometrial cancer analyzed. CD44 also did not coimmunoprecipitate or colocalize with erbB2 in two endometrial carcinoma cell lines. We propose that the lack of CD44-erbB2 interactions may reduce the contribution of erbB2 to endometrial carcinoma progression.
authors.affiliation: Department of Cell Biology, Neurobiology and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0521, USA.
authors.forename: Manja
authors.initials: M
authors.lastname: Wobus
authors.forename: Robin
authors.initials: R
authors.lastname: Kuns
authors.forename: Irene
authors.initials: I
authors.lastname: Sheyn
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Werness
authors.forename: Nader
authors.initials: N
authors.lastname: Husseinzadeh
authors.forename: Bernard S
authors.initials: BS
authors.lastname: Aron
authors.forename: Larry S
authors.initials: LS
authors.lastname: Sherman
mesh_terms: D016889:Endometrial Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D018960:Hyaluronan Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases