Hemoglobin-based oxygen carriers.
Three types of materials have been studied as candidate blood substitutes: the perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin. Progress has been greatest with the hemoglobin-based oxygen carriers. Hemoglobin is a highly active molecule; hence, modification has been required to avoid potential deleterious effects. Although there has been considerable progress toward bringing such a product to the clinic, its development has challenged understanding of oxygen delivery and use. The study of these molecules has provided new insights into basic physiologic processes.
Stowell
Christopher P
CP
Blood Transfusion Service, Massachusetts General Hospital, Boston, 02114, USA. cstowell@partners.org
D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002986:Clinical Trials as Topic; D006454:Hemoglobins / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D016896:Treatment Outcome
D001802:Blood Substitutes; D006454:Hemoglobins; D010100:Oxygen