Direct synthesis of guanidines using di(imidazole-1-yl)methanimine.
A direct synthetic approach to guanidine compounds is reported here using di(imidazole-1-yl)methanimine and di(imidazole-1-yl)cyanomethanimine as guanylating reagents.
Wu
Yong-Qian
YQ
Department of Research, Guilford Pharmaceuticals, Inc., Baltimore, Maryland 21224, USA. wuy@guilfordpharm.com
Hamilton
Sean K
SK
Wilkinson
Douglas E
DE
Hamilton
Gregory S
GS
D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008744:Methylamines; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D006146:Guanidines; D007093:Imidazoles; D007202:Indicators and Reagents; D008744:Methylamines