Symptomatic neurological epidural metastasis with interleukin-2 therapy in metastatic renal cell carcinoma.
Interleukin-2 has known efficacy in the treatment of metastatic renal cell carcinoma but it also has adverse effects mediated by an inflammatory mechanism and capillary leak syndrome. The authors report the case of a patient with a metastatic renal cell carcinoma who had an asymptomatic intra-epidural metastasis in the thoracic spine, which became symptomatic during IL-2 administration without any recurrence after specific treatment by surgery and radiotherapy.
Trufflandier
Nathalie
N
Institut Bergonié, Regional Cancer Center, Bordeaux, France. trufflandier@bergonie.org
Gille
Olivier
O
Palussière
Jean
J
Prié
Loïc
L
Pointillart
Vincent
V
Ravaud
Alain
A
D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D015174:Epidural Neoplasms / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013904:Thoracic Vertebrae
D007376:Interleukin-2