title: Diamine-catalyzed asymmetric Michael additions of aldehydes and ketones to nitrostyrene.
abstract: [reaction: see text] The direct Michael addition of aldehydes and ketones to nitrostyrene, catalyzed by N-i-Pr-2,2'-bipyrrolidine, is described. The desired 1,4-adducts are obtained in excellent yield with enantioselectivities up to 85% ee and dr up to 95:5 of the syn product.
authors.affiliation: Chimie Organique, Sciences II, University of Geneva, Quai Ernest Ansermet, CH-1211, Geneva, Switzerland. alexandre.alexakis@chiorg.unige.ch
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis
authors.forename: Olivier
authors.initials: O
authors.lastname: Andrey