In vitro antibacterial activities of phloxine B and other halogenated fluoresceins against methicillin-resistant Staphylococcus aureus.
Fluorescein dyes in which the benzoic acid moiety has been tetrachlorinated (50 to 100 micro g/ml) inhibit in vitro Staphylococcus aureus growth (MIC, 25 micro g/ml). Specifically, under standard room illumination, phloxine B at a concentration of 100 micro g/ml killed 99% of the cultures (mid-log phase). It also reduced S. aureus CFU by 10(4). Structure-activity analysis revealed that the activity against S. aureus increases with the increase in the number of the substituting halogens in the hydroxyxanthene moiety.
Rasooly
Avraham
A
Office of Plant and Dairy Foods and Beverages, U.S. Food and Drug Administration, College Park, Maryland 20740, USA.
Weisz
Adrian
A
D003470:Culture Media; D010697:Eosine I Bluish / Q000494:pharmacology*; D005452:Fluoresceins / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000494:pharmacology*; D008027:Light; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D003470:Culture Media; D005452:Fluoresceins; D005456:Fluorescent Dyes; D010697:Eosine I Bluish