Pathological Q-wave generation in light of the Q wave alteration resulting from myocardial infarction in the left ventricular lateral wall of New Zealand rabbits.
OBJECTIVE
To explore the mechanism of pathological Q-wave generation in light of Q-wave alteration recorded on body surface resulting from the myocardial infarction in left ventricular lateral wall of New Zealand rabbits.


METHODS
Electrocardiogram (ECG) was recorded with Wilson lead system at the surface points of chest and back in 30 normal rabbits. The myocardiac infarction models were prepared with quantitative chemical damaging method, and the ECG was recorded at the same points. Through comparison with the recorded ECG in normal animals, cases with pathological Q-wave at the recorded sites were identified and counted.


RESULTS
Pathological Q waves appeared at the point toward the infarction region, which was not observed in the area of right ventricular lateral wall opposite to the infarction region, showing significant difference (P<0.05).


CONCLUSIONS
Negative potential transmitting from the ventricular chamber to the body surface through the window of infarction region may be involved in the generation of pathological Q waves.
Zhou
Xiang
X
Research Center of Electrocardiology, First Military Medical University, Guangzhou 510515, China.
Zhu
Hao
H
Yin
Bing-Sheng
BS
D000818:Animals; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits