title: Hepatitis C: molecular virology and antiviral targets.
abstract: Chronic hepatitis C is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. Although current treatment options are limited, progress in understanding the molecular virology of hepatitis C has led to the identification of novel antiviral targets. Moreover, in vitro and in vivo model systems have been developed that allow systematic evaluation of new therapeutic strategies. This review details current concepts in molecular virology and emerging therapies for hepatitis C.
authors.affiliation: Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, Germany. Darius.Moradpour@uni-freiburg.de
authors.forename: Darius
authors.initials: D
authors.lastname: Moradpour
authors.forename: Volker
authors.initials: V
authors.lastname: Brass
authors.forename: Rainer
authors.initials: R
authors.lastname: Gosert
authors.forename: Benno
authors.initials: B
authors.lastname: Wölk
authors.forename: Hubert E
authors.initials: HE
authors.lastname: Blum
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D005814:Genes, Viral; D016174:Hepacivirus / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D006526:Hepatitis C / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy* / Q000821:virology*; D006801:Humans; D008958:Models, Molecular; D011499:Protein Processing, Post-Translational; D020836:Protein Structure, Quaternary; D015678:Viral Structural Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D015678:Viral Structural Proteins