A self-defence mechanism of astrocytes against Fas-mediated death involving interleukin-8 and CXCR2.
Astrocytes play multiple roles from passive support to the regulation of inflammation during brain injury. This latter function is in part achieved by responses induced by the triggering of Fas expressed on astrocytes both and. It was previously shown that astrocytes are resistant to Fas-mediated death, responding to Fas triggering by interleukin-8 production. However, the cellular mechanisms by which astrocytes protect themselves from Fas-mediated death are unclear. Here, we show that survival of cultured astrocytes after Fas triggering is governed by the interaction of interleukin-8 with one of its receptors, CXCR2. Furthermore, interleukin-8 secretion and CXCR2 expression are both induced in human astrocytes after Fas stimulation, suggesting a new mechanism of self-defence against Fas-mediated death.
Saas
Philippe
P
Laboratory of Tumor Immunology, Division of Oncology, University Hospital, Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland.
Walker
Paul R
PR
Quiquerez
Anne-Lise
AL
Chalmers
David E
DE
Arrighi
Jean-François
JF
Liénard
Agnès
A
Boucraut
José
J
Dietrich
Pierre-Yves
PY
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000911:Antibodies, Monoclonal; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D004660:Encephalitis / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D011112:Polymyxin B / Q000494:pharmacology; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D023062:Receptors, Interleukin-8A / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D019014:fas Receptor / Q000378:metabolism* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal; D016209:Interleukin-8; D012333:RNA, Messenger; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; D019014:fas Receptor; D011112:Polymyxin B