title: Long-term effect of body weight-supported treadmill training in Parkinson's disease: a randomized controlled trial.
abstract: OBJECTIVE
  To investigate whether body weight-supported treadmill training (BWSTT) is of long-term benefit for patients with Parkinson's disease (PD).
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Inpatient rehabilitation unit for neurologic diseases in Japan.
  
  
  METHODS
  Twenty-four patients (Hoehn and Yahr stages 2.5 or 3) who were not demented (Mini-Mental State Examination score, >27).
  
  
  METHODS
  Patients were randomized to receive either a 45-minute session of BWSTT (up to 20% of body weight supported) or conventional physical therapy (PT) for 3 days a week for 1 month.
  
  
  METHODS
  Outcome measures were evaluated at baseline and at 1, 2, 3, and 6 months. Measures included the Unified Parkinson's Disease Rating Scale (UPDRS), ambulation speed (s/10 m), and number of steps taken for a 10-m walk as a parameter for stride length.
  
  
  RESULTS
  Four patients needed modification of medications in the follow-up period. Twenty patients (BWSTT, n=11; PT, n=9) without modified medications were analyzed for functional outcome. Age, duration of PD, gender, and doses of medications were comparable. There was no difference in the baseline UPDRS (BWSTT=33.3; PT=32.6), speed (BWSTT=10.8; PT=11.5), and steps (BWSTT=23.4; PT=22.8). The BWSTT group had significantly greater improvement than the PT group (Mann-Whitney U test, Bonferroni adjustment for multiple comparison) in ambulation speed at 1 month (BWSTT=8.5; PT=10.8; P<.005); and in the number of steps at 1 (BWSTT=20.0; PT=22.7; P<.005), 2 (BWSTT=19.5; PT=22.4; P<.005), 3 (BWSTT=20.1; PT=23.1; P<.005), and 4 months (BWSTT=21.0; PT=23.0; P=.006).
  
  
  CONCLUSIONS
  BWSTT has a lasting effect specifically on short-step gait in PD.
authors.affiliation: Neurorehabilitation Research Institute, Bobath Memorial Hospital, Osaka, Japan. webeo@ga2.so-net.ne.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Miyai
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Yoshishige
authors.initials: Y
authors.lastname: Ueda
authors.forename: Toshio
authors.initials: T
authors.lastname: Saito
authors.forename: Sonoko
authors.initials: S
authors.lastname: Nozaki
authors.forename: Jin
authors.initials: J
authors.lastname: Kang
mesh_terms: D000368:Aged; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000503:physiopathology / Q000534:rehabilitation*; D026741:Physical Therapy Modalities / Q000379:methods*; D016896:Treatment Outcome