Peritoneal fluid, endometriosis, and ciliary beat frequency in the human fallopian tube.
Endometriosis and infertility are known to be associated, but it is unclear whether endometriosis causes infertility. We used contrast analogue enhancement to study the effect of peritoneal fluid from women with early stage endometriosis on the ciliary beat frequency of human fallopian tube epithelium. We obtained peritoneal fluid from six women with early stage endometriosis and from six fertile women with no evidence of endometriosis to use as controls. Fallopian tubes from hysterectomy specimens were collected from 17 women. The difference in ciliary beat frequency between fallopian tubes exposed to peritoneal fluids of women with and without endometriosis increased with the duration of incubation (mean difference at 24 h 1.35 Hz, 95% CI 0.94-1.75, p=0.01). At 24 h, ciliary beat frequency was significantly lower in the incubations with peritoneal fluid from women with endometriosis than controls (4.29 [0.15] vs 5.64 Hz [0.15], respectively, p=0.001). Impairment of ciliary action in women with endometriosis might reduce fertility.
Lyons
Rachel A
RA
Academic Department of Obstetrics and Gynaecology, St Bartholomew's Hospital and The London School of Medicine and Dentistry, London, UK.
Djahanbakhch
Ovrang
O
Saridogan
Ertan
E
Naftalin
Alan A
AA
Mahmood
Tariq
T
Weekes
Anthony
A
Chenoy
Rashna
R
D000328:Adult; D000704:Analysis of Variance; D001202:Ascitic Fluid; D016022:Case-Control Studies; D002923:Cilia; D004715:Endometriosis / Q000150:complications* / Q000503:physiopathology; D005187:Fallopian Tubes; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D013997:Time Factors