title: Malaria: new chemotherapeutic peroxide drugs.
abstract: Chemical insights into artemisinin's biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.
authors.affiliation: Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Borstnik
authors.forename: Ik-Hyeon
authors.initials: IH
authors.lastname: Paik
authors.forename: Gary H
authors.initials: GH
authors.lastname: Posner
mesh_terms: D000818:Animals; D018692:Antimanic Agents / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000627:therapeutic use*; D010961:Plasmodium / Q000187:drug effects* / Q000302:isolation & purification; D013329:Structure-Activity Relationship
chemical_list: D018692:Antimanic Agents; D010545:Peroxides