Novel terpenoids from the formosan soft coral Cespitularia hypotentaculata.
Four new cytotoxic diterpenes, cespitularins A-D (1-4), having the verticillane skeleton, a new cytotoxic norditerpene, cesputularin E (5), that possesses a novel norverticillane skeleton, and three new diterpenes, cespitularins F-H (6-8), possessing a novel carbon skeleton named cespitularane, were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata. The structures of cespitularins A-H (1-8) were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Duh
Chang-Yih
CY
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. yihduh@mail.nsysu.edu.tw
El-Gamal
Ali Ali H
AA
Wang
Shang-Kwei
SK
Dai
Chang-Feng
CF
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes