Treatment of experimental nephrosis by culture filtrate of Cryptococcus neoformans var. gattii (CneF).
The therapeutic effect of the culture filtrate of cryptococcus neoformans var. gattii (CneF) was tested in Adriamycin-induced nephropathy. The CneF was administered at different doses (36, 54 and 90 mg/kg based on carbohydrate concentration), one i.p. injection every 72 hours for a total of 10 injections. The treated patient rats showed a significant reduction in proteinuria, plasma cholesterol concentration, BUN and significant increase in urine creatinine levels. Moreover, treatment with CneF significantly reduced number of glomerular leukocytes and decreased the tubular casts. These data suggest that CneF therapy can ameliorate proteinuria, hypercholesterolemia and suppress the progression of glomerular lesions in experimental model of nephrosis.
Mirshafiey
Abbas
A
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Iran. mirshafiey_tums_edu_ir@yahoo.com
Razavi
Alireza
A
Mehrabian
Farhad
F
Moghaddam
Mohammad R Nikouei
MR
Hadjavi
Masoumeh
M
D000818:Animals; D000946:Antigens, Fungal / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003455:Cryptococcus neoformans / Q000276:immunology*; D005260:Female; D005374:Filtration; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011134:Polysaccharides / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000946:Antigens, Fungal; D007166:Immunosuppressive Agents; D011134:Polysaccharides; C027478:glucuronoxylomannan; D002784:Cholesterol