Heparin-releasing intravascular guidewires.
The distal part of a percutaneous translumenal coronary angioplasty (PTCA) guidewire should not only be flexible, nonkinking, radiopaque and lubricious, but also nonthrombogenic. Possible formation of thrombotic emboli at a guidewire's surface enhances the risk for occlusion at the coronary lesion downstream. This article reports on the development of a new PTCA guidewire that releases heparin from the lubricious hydrophilic coating on its distal part.
Hanssen
Hans J L
HJ
MCTec BV, Venlo, The Netherlands. hans@mctecbv.com
Koole
Leo H
LH
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation* / Q000379:methods; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D003328:Coronary Thrombosis / Q000517:prevention & control*; D004337:Drug Carriers; D004867:Equipment Design; D006041:Goats; D006493:Heparin / Q000008:administration & dosage*; D011108:Polymers / Q000627:therapeutic use
D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D011108:Polymers; D006493:Heparin