title: Canine leishmaniasis: epidemiological risk and the experimental model.
abstract: Increasing risk factors are making zoonotic visceral leishmaniasis a growing public health concern in many countries. Domestic dogs constitute the main reservoir of Leishmania infantum and Leishmania chagasi, and play a key role in the transmission to humans. New reagents and tools allow the detailed investigation of canine leishmaniasis, permitting the monitoring of the immunological status of dogs in both natural and experimental infections. Such studies are essential to determine the basis of the canine protective immune response and to establish a laboratory model, a significant aspect for the development of vaccines against canine leishmaniasis.
authors.affiliation: WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologi;a, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo km 2, 28220 Majadahonda, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Moreno
authors.forename: Jorge
authors.initials: J
authors.lastname: Alvar
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000453:epidemiology* / Q000276:immunology / Q000469:parasitology*; D004285:Dogs; D005260:Female; D006801:Humans; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000453:epidemiology* / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D008297:Male; D016052:Protozoan Vaccines / Q000276:immunology / Q000592:standards
chemical_list: D016052:Protozoan Vaccines