Studies on the biomimetic synthesis of SNF4435 C and D.
[reaction: see text] The biomimetic synthesis of the bicyclic core of the novel immunosuppresants SNF4435C and SNF4435D is reported. The core framework was efficiently generated from the all-trans tetraene precursor in one step and in good yield.
Moses
John E
JE
Chemical Crystallography, Oxford University, South Parks Road, Oxford OX1 3QR, U.K.
Baldwin
Jack E
JE
Marquez
Rodolfo
R
Adlington
Robert M
RM
Cowley
Andrew R
AR
D018716:Molecular Mimicry; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D009574:Nitro Compounds; D011753:Pyrones; C435067:SNF 4435C; C435066:SNF 4435D