title: Integrated technology platform protein kinases for drug development in oncology.
abstract: Protein kinases are among the most promising targets for drug discovery and development, mostly in oncology but also in other fields such as inflammation, Alzheimer's, and infectious diseases. The Integrated Technology Platform Protein Kinases was designed as a comprehensive tool for drug discovery in thefield of oncology. It combines modules for the identification and validation of novel target protein kinases, a unique panel of active recombinant protein kinases, high-throughput screening, selectivity profiling, cellular testing, and in vivo tumor models. Here we give an overview of the Integrated Technology Platform Protein Kinases as well as data that validate each module.
authors.affiliation: ProQinase GmbH, Freiburg, Germany. c.sachsenmaier@proqinase.com
authors.forename: Christoph
authors.initials: C
authors.lastname: Sachsenmaier
authors.forename: Christoph
authors.initials: C
authors.lastname: Schächtele
mesh_terms: D016475:3T3 Cells / Q000187:drug effects; D000818:Animals; D001331:Automation; D016466:CHO Cells / Q000187:drug effects; D002846:Chromatography, Affinity; D003001:Cloning, Molecular; D006224:Cricetinae; D003412:Cricetulus; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D020869:Gene Expression Profiling / Q000295:instrumentation; D005799:Genes, Dominant; D005816:Genetic Complementation Test; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D020411:Oligonucleotide Array Sequence Analysis; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000235:genetics / Q000302:isolation & purification / Q000592:standards; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000592:standards; D015203:Reproducibility of Results; D012371:Robotics; D013379:Substrate Specificity; D013382:Subtraction Technique; D014407:Tumor Cells, Cultured / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D004791:Enzyme Inhibitors; D009363:Neoplasm Proteins; D047428:Protein Kinase Inhibitors; D011994:Recombinant Proteins; D011494:Protein Kinases