Neural expression of mouse Noelin-1/2 and comparison with other vertebrates.
Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8-10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the cranial ganglia. Later, expression is prominent in brain tissue and in the zone of polarizing activity in the limb.
Moreno
Tanya A
TA
Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA.
Bronner-Fraser
Marianne
M
D000818:Animals; D002642:Chick Embryo; D003001:Cloning, Molecular; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D017403:In Situ Hybridization; D051379:Mice; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009432:Neural Crest / Q000196:embryology; D009474:Neurons / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014981:Xenopus
D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D009419:Nerve Tissue Proteins; C081451:olfactomedin