title: Lower dose of ciprofloxacin is adequate for the treatment of Neisseria gonorrhoeae in KwaZulu Natal, South Africa.
abstract: The response of male gonococcal urethritis to a single 250 mg dose of ciprofloxacin versus 500 mg was studied. Both regimens were given in combination with doxycycline in the context of the local syndromic management protocol. There was no significant difference in response between the regimens, inclusive/exclusive of tetracycline susceptible isolates. One patient in the 250 mg arm failed to respond clinically but was microbiologically cured and four patients in the 500 mg arm failed microbiologically but responded clinically. All four isolates had ciprofloxacin MICs </=0.007 mg/l.
authors.affiliation: The Africa Centre for Health and Population Studies and The Department of Medical Microbiology, Nelson R. Mandela School of Medicine, University of Natal, Durban, P/Bag 7, 4013, Congella, South Africa.
authors.forename: Prashini
authors.initials: P
authors.lastname: Moodley
authors.forename: Chinsamy
authors.initials: C
authors.lastname: Pillay
authors.forename: Gladys
authors.initials: G
authors.lastname: Nzimande
authors.forename: Yacoob M
authors.initials: YM
authors.lastname: Coovadia
authors.forename: A Willem
authors.initials: AW
authors.lastname: Sturm
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D011446:Prospective Studies; D013019:South Africa; D014526:Urethritis / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D004318:Doxycycline