title: Is prophylactic aortic valve replacement indicated during mitral valve surgery for mild to moderate aortic valve disease?
abstract: BACKGROUND
  Determining the need for surgical treatment of coexisting mild to moderate aortic valve disease in patients referred for mitral valve surgery is often difficult. The purpose of this study was to assess long-term clinical outcome and the need for subsequent aortic valve replacement in patients with mild to moderate rheumatic aortic valve disease at the time of mitral valve surgery.
  
  
  METHODS
  A total of 275 patients (90 men and 185 women, mean age 43 years) with rheumatic disease who underwent mitral valve surgery were followed up for an average of 9 years. Patients were classified into two groups: those with coexisting mild to moderate aortic valve disease at the time of mitral valve surgery (141 patients, group A) and those without (134 patients, group B). Primary outcomes (death and subsequent aortic valve surgery) were compared between the two groups.
  
  
  RESULTS
  At the time of mitral valve surgery, 104 patients (74%) in group A had mild aortic regurgitation, 37 (26%) had moderate aortic regurgitation, 5 had (4%) mild aortic stenosis, and 2 (1%) had moderate aortic stenosis. At the end of follow-up, no patient had severe aortic valve disease. In all, 12 patients (5%) in group A had primary events (eight deaths and four subsequent aortic valve replacements), and 12 patients (9%) in group B had such events (12 deaths). According to Kaplan-Meier analysis, neither the survival rate nor the event-free survival rate differed significantly over the follow-up period between the two groups.
  
  
  CONCLUSIONS
  In most patients who have mild to moderate rheumatic aortic valve disease at the time of mitral valve surgery, the long-term outcome is comparable to that of subjects without aortic valve disease at the time of mitral valve surgery. Subsequent aortic valve replacement is rarely needed after a long follow-up period.
authors.affiliation: Department of Preventive Medicine and Public Health, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. jwha@yumc.yonsei.ac.kr
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Ha
authors.forename: Seung-Hyuck
authors.initials: SH
authors.lastname: Choi
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Chang
authors.forename: Chung Mo
authors.initials: CM
authors.lastname: Nam
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Namsik
authors.initials: N
authors.lastname: Chung
authors.forename: Won-Heum
authors.initials: WH
authors.lastname: Shim
authors.forename: Seung-Yun
authors.initials: SY
authors.lastname: Cho
authors.forename: Sung-Soon
authors.initials: SS
authors.lastname: Kim
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000150:complications; D001024:Aortic Valve Stenosis / Q000150:complications; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D012214:Rheumatic Heart Disease / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome