title: Comparative study of cerebral blood flow between postural tachycardia and neurocardiogenic syncope, during head-up tilt test.
abstract: We assessed the cerebral blood flow velocity response to head-up tilt test in patients with typical neurocardiogenic syncope compared with patients showing postural tachycardia. Fifty patients (21 men) with history of orthostatic intolerance, younger than 50 years (mean 27 +/- 10), participated in the study. Transcranial Doppler sonography of the middle cerebral artery, heart rate and brachial blood pressure were recorded during a head-up tilt test. According to the outcome of the test, patients were categorized in two groups: neurocardiogenic syncope (29 patients) and postural tachycardia (21 patients). The clinical history of the two groups was similar. During baseline in the supine position, no differences in haemodynamic parameters were observed. From the first min of tilt, the heart rate was higher in patients with postural tachycardia than in patients with neurocardiogenic syncope. Although, during tilt, the absolute values of the cerebral blood flow parameters were similar in the two groups, throughout tilt, continuous observation of the Doppler recording in patients with postural tachycardia showed intermittent fluctuation of the blood flow velocity, with an oscillatory pattern, which were not observed in the recordings in patients with neurocardiogenic syncope. Comparison of patients with neurocardiogenic syncope, and those with postural tachycardia also showed larger variations of the pulsatility index (P < 0.05) in the postural tachycardia group. These findings support the possibility that abnormalities within the central nervous system play a pivotal role in the pathogenesis of postural tachycardia.
authors.affiliation: Departamento de Electrofisiologia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico DF.
authors.forename: A G
authors.initials: AG
authors.lastname: Hermosillo
authors.forename: K
authors.initials: K
authors.lastname: Jauregui-Renaud
authors.forename: A
authors.initials: A
authors.lastname: Kostine
authors.forename: M F
authors.initials: MF
authors.lastname: Marquez
authors.forename: J L
authors.initials: JL
authors.lastname: Lara
authors.forename: M
authors.initials: M
authors.lastname: Cardenas
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D012039:Regional Blood Flow; D019462:Syncope, Vasovagal / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013610:Tachycardia / Q000503:physiopathology*; D018667:Tilt-Table Test; D017585:Ultrasonography, Doppler, Transcranial