Severe neutropenia due to naproxen therapy in rheumatoid arthritis: a case report and review of literature.
Rheumatoid arthritis is a chronic inflammatory disease that primarily affects the joints and is often treated with non-steroidal anti-inflammatory drugs (NSAIDs) on demand and disease-modifying antirheumatic drugs (DMARDs), with a relatively low risk of side effects. Although an infrequent side effect, neutropenia has been described as a sequel of NSAIDs. We report a case of neutropenia proven (by rechallenge) to be due to naproxen therapy. The literature on neutropenia during treatment with NSAIDs and DMARDs is briefly reviewed.
Kalksma
R
R
Leeuwarden Medical Centre, Department of Rheumatology, The Netherlands.
Jansen
T L Th A
TL
Bruyn
G A W
GA
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects*; D009503:Neutropenia / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen