title: Fulminant Guillain-Barré syndrome after Campylobacter jejuni enteritis and monospecific anti-GT1a IgG antibody.
abstract: A 21-year-old man developed rapid progression of tetraplegia, bulbar palsy, and respiratory paralysis after Campylobacterjejuni enteritis. Based on the diagnosis of Guillain-Barré syndrome, he received plasmapheresis and intravenous immunoglobulin. Serum anti-GT1a IgG antibody which lacked cross-reactivity with GQ1b was detected. Four months after the onset, the patient still had severe muscle weakness of the lower limbs. This case suggests that anti-GT1a IgG antibody can be associated with severe paralysis in Guillain-Barré syndrome after C. jejuni enteritis.
authors.affiliation: Department of Neurology, Ehime Prefectural Central Hospital, Matsuyama.
authors.forename: Bungo
authors.initials: B
authors.lastname: Okuda
authors.forename: Michiaki
authors.initials: M
authors.lastname: Koga
authors.forename: Tomoya
authors.initials: T
authors.lastname: Katsuta
authors.forename: Kensho
authors.initials: K
authors.lastname: Okamoto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002169:Campylobacter Infections / Q000150:complications* / Q000276:immunology; D016123:Campylobacter jejuni / Q000302:isolation & purification*; D004751:Enteritis / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D010956:Plasmapheresis / Q000379:methods; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D005677:G(M1) Ganglioside