Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones.
A series of novel 2-phenyl-3-substituted quinazolin-4(3H)-ones have been synthesized by treating methyl-N-(2-phenyl quinazolin-3-yl-4(3H)-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds A1, A2 and A3 shown more potent analgesic activity, and the compound A3 shown more potent anti-inflammatory activity than the reference standard diclofenac sodium.
Alagarsamy
Veerachamy
V
Medicinal Chemistry Laboratory, SB College of Pharmacy, Sivakasi, India. samy_veera@yahoo.com
Salomon
Viswas Raja
VR
Vanikavitha
Gnanavel
G
Paluchamy
Veeran
V
Chandran
Muniyandi Ravi
MR
Sujin
Augustin Arnald
AA
Thangathiruppathy
Arunachalam
A
Amuthalakshmi
Sivaperuman
S
Revathi
Rajappan
R
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines