[Study on chemotherapy-induced disorders of glucose metabolism in patients with malignant ovarian tumor].
OBJECTIVE
To determine the effect of chemotherapy on glucose metabolism in patients with malignant ovarian tumor.


METHODS
The blood glucose assay and associated clinical materials of 375 cases with malignant ovarian tumor who received chemotherapy from January 1997 to December 2001 were analyzed retrospectively.


RESULTS
Thirty-two cases (8.5%) had elevated fasting blood glucose after chemotherapy. Among them, 14 cases (3.7%) were diagnosed as diabetes mellitus, 9 cases (2.4%) were diagnosed as impaired glucose tolerance. Paclitaxel based chemotherapy seemed to have more opportunity to induce disorders of glucose metabolism than that in cisplatin based chemotherapy (P < 0.05), and this happened most frequently in 1 approximately 3 courses.


CONCLUSIONS
Chemotherapy may induce disorders of glucose metabolism, which most frequently occurred in 1 approximately 3 courses, including impaired glucose tolerance or diabetes mellitus,especially in patients received paclitaxel chemotherapy.
Zhang
Junji
J
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Shen
Keng
K
Lang
Jinghe
J
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy*; D017239:Paclitaxel / Q000009:adverse effects
D001786:Blood Glucose; D017239:Paclitaxel