Anti-heparan sulfate antibodies in neurological disease.
Antibodies to heparan sulfate (HS) have previously been found in association with peripheral neuropathy. We tested sera from patients with neuropathies and with other neurological diseases for antibodies to HS using an avidin-biotin enzyme-linked immunosorbent assay (ELISA) system. Increased titers of anti-HS antibodies were found in 3.4% of patients with neuropathy, and in 3% of patients with other neurological diseases. In all cases, however, an inflammatory disease was present, including chronic inflammatory neuropathy, cerebral vasculitis, or multiple sclerosis. Antibodies to HS appear not to be specific for neuropathy, as they occur in several inflammatory diseases. They might contribute to the associated breakdown of the blood-brain or blood-nerve barrier.
Briani
Chiara
C
Department of Neurological and Psychiatric Sciences, University of Padova, Via Giustiniani 5, 35128 Padova, Italy. chiara.briani@unipd.it
Ruggero
Susanna
S
Alaedini
Armin
A
Nardelli
Ettore
E
Ferrari
Sergio
S
Wirguin
Itzhak
I
Zara
Gabriella
G
Battistin
Leontino
L
Latov
Norman
N
D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006497:Heparan Sulfate / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D010525:Peripheral Nerves / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000097:blood* / Q000276:immunology*
D001323:Autoantibodies; D006497:Heparan Sulfate; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein