Dueling activities of AIF in cell death versus survival: DNA binding and redox activity.
Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.
Lipton
Stuart A
SA
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA. slipton@burnham.org
Bossy-Wetzel
Ella
E
D000818:Animals; D017209:Apoptosis; D051033:Apoptosis Inducing Factor; D016923:Cell Death; D002470:Cell Survival; D004247:DNA / Q000378:metabolism*; D005420:Flavoproteins / Q000502:physiology*; D016166:Free Radical Scavengers / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D008958:Models, Molecular; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000502:physiology
C494829:AIFM1 protein, human; D051033:Apoptosis Inducing Factor; D005420:Flavoproteins; D016166:Free Radical Scavengers; D008565:Membrane Proteins; C494830:AIFM1 protein, mouse; D009243:NAD; D004247:DNA; D010088:Oxidoreductases