title: Trifluoromethyl ketones as inhibitors of histone deacetylase.
abstract: Trifluoromethyl ketones were found to be inhibitors of histone deacetylases (HDACs). Optimization of this series led to the identification of submicromolar inhibitors such as 20 that demonstrated antiproliferative effects against the HT1080 and MDA 435 cell lines.
authors.affiliation: Cancer Research, Abbott Laboratories, Abbott Park, IL 60064, USA. robin.r.frey@abbott.com
authors.forename: Robin R
authors.initials: RR
authors.lastname: Frey
authors.forename: Carol K
authors.initials: CK
authors.lastname: Wada
authors.forename: Robert B
authors.initials: RB
authors.lastname: Garland
authors.forename: Michael L
authors.initials: ML
authors.lastname: Curtin
authors.forename: Michael R
authors.initials: MR
authors.lastname: Michaelides
authors.forename: Junling
authors.initials: J
authors.lastname: Li
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Pease
authors.forename: Keith B
authors.initials: KB
authors.lastname: Glaser
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Marcotte
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Bouska
authors.forename: Shannon S
authors.initials: SS
authors.lastname: Murphy
authors.forename: Steven K
authors.initials: SK
authors.lastname: Davidsen
mesh_terms: D000107:Acetylation; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005354:Fibrosarcoma / Q000378:metabolism; D056572:Histone Deacetylase Inhibitors; D006657:Histones / Q000378:metabolism; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry / Q000494:pharmacology; D007659:Ketones / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006845:Hydrocarbons, Fluorinated; D007659:Ketones