Microwave-assisted solid-phase synthesis of peptoids.
Microwave irradiation reduces the reaction time for the solid-phase synthesis of peptoids. Under these conditions, coupling of each residue requires only 1 min. The purity and yields of peptoids synthesized in this way are as good as or better than those achieved using standard methods. [reaction: see text]
Olivos
Hernando J
HJ
Center for Biomedical Inventions, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-8573, USA.
Alluri
Prasanna G
PG
Reddy
M Muralidhar
MM
Salony
Derek
D
Kodadek
Thomas
T
D000595:Amino Acid Sequence; D007202:Indicators and Reagents; D008872:Microwaves; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects
D007202:Indicators and Reagents; D010455:Peptides; D034444:Peptoids