title: Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up.
abstract: OBJECTIVE
  To assess the effect of ovarian stimulation with recombinant FSH, GnRH antagonists, and hCG on endometrial maturation on the day of oocyte pick-up.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Fifty-five women undergoing controlled ovarian hyperstimulation for IVF/intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  [1] Ovarian stimulation with recombinant FSH, starting on day 2 of the cycle and GnRH antagonist, starting after a median of 6 days of recombinant FSH stimulation (range, 5-12 days); [2] hCG administration for ovulation induction; and [3] aspirational biopsy of endometrium at oocyte pick-up.
  
  
  METHODS
  Endometrial histology at oocyte pick-up by Noyes criteria.
  
  
  RESULTS
  Advancement of endometrial maturation (2.5 +/- 0.1 days) as compared to the expected chronological date was observed in all antagonist cycles at oocyte retrieval. Endometrial advancement at oocyte pick-up increased in line with values of LH at initiation of stimulation and the duration of recombinant FSH treatment before the antagonist was started.
  
  
  CONCLUSIONS
  The higher the values of LH at initiation of stimulation and the longer the duration of recombinant FSH treatment before the antagonist is started, the more advanced the endometrial maturation at oocyte pick-up.
authors.affiliation: Centre for Reproductive Medicine, Dutch-Speaking Brussels Free University, Brussels, Belgium. stratis@easynet.be
authors.forename: Efstratios
authors.initials: E
authors.lastname: Kolibianakis
authors.forename: Claire
authors.initials: C
authors.lastname: Bourgain
authors.forename: Carola
authors.initials: C
authors.lastname: Albano
authors.forename: Kaan
authors.initials: K
authors.lastname: Osmanagaoglu
authors.forename: Johan
authors.initials: J
authors.lastname: Smitz
authors.forename: Andre
authors.initials: A
authors.lastname: Van Steirteghem
authors.forename: Paul
authors.initials: P
authors.lastname: Devroey
mesh_terms: D000328:Adult; D001706:Biopsy; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D009865:Oocytes; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting
chemical_list: D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone