title: A vectorized method of importance sampling with applications to models of mutation and migration.
abstract: An importance-sampling method is presented for computing the likelihood of the configuration of population genetic data under general assumptions about population history and transitions among states. The configuration of the data is the number of chromosomes sampled that are in each of a finite set of states. Transitions among states are governed by a Markov chain with transition probabilities dependent on one or more parameters. The method assumes that the joint distribution of coalescence times of the underlying gene genealogy is independent of the genetic state of each lineage. Given a set of coalescence times, the probability that a pair of lineages is chosen to coalesce in each replicate is proportional to the contribution that the coalescence event makes to the probability of the data. This method can be applied to gene genealogies generated by the neutral coalescent process and to genealogies generated by other processes, such as a linear birth-death process which provides a good approximation to the dynamics of low-frequency alleles. Two applications are described. In the first, the fit of allele frequencies at two microsatellite loci sampled in a Sardinian population to the one-step mutation model is tested. The one-step model is rejected for one locus but not for the other. The second application is to low-frequency alleles in a geographically subdivided population. The geographic location is the allelic state, and the alleles are assumed to be sufficiently rare that their dynamics can be approximated by a linear birth-death process in which the birth and death rates are independent of geographic location. The analysis of eight low-frequency allozyme alleles found in the glaucous-winged gull, Larus glaucescens, illustrates how geographically restricted dispersal can be detected.
authors.affiliation: Department of Integrative Biology, University of California, Berkeley, California 94720-3140, USA. slatkin@socrates.berkeley.edu
authors.forename: Montgomery
authors.initials: M
authors.lastname: Slatkin
mesh_terms: D000483:Alleles; D025041:Animal Migration; D000818:Animals; D001717:Birds / Q000235:genetics / Q000502:physiology*; D005787:Gene Frequency; D005828:Genetics, Population; D016013:Likelihood Functions; D018895:Microsatellite Repeats; D008954:Models, Biological; D009154:Mutation