De Novo design, synthesis, and in vitro evaluation of a new class of nonpeptidic inhibitors of the malarial enzyme plasmepsin II.
Carcache
David A
DA
Laboratorium für Organische Chemie ETH-Hönggerberg, HCI 8093 Zürich, Switzerland.
Hörtner
Simone R
SR
Bertogg
Andreas
A
Binkert
Christoph
C
Bur
Daniel
D
Märki
Hans Peter
HP
Dorn
Arnulf
A
Diederich
François
F
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000201:enzymology; D015800:Protozoan Proteins; D013329:Structure-Activity Relationship
D000962:Antimalarials; D004791:Enzyme Inhibitors; D015800:Protozoan Proteins; D016282:Aspartic Acid Endopeptidases; C100637:plasmepsin II