Unchain my heart, baby let me go--the entry and intracellular transport of HIV.
In this issue, McDonald et al. describe the itinerary of the incoming human immunodeficiency virus (HIV) during its travels to the host nucleus. They show that subviral particles tagged with the green fluorescent protein (GFP) are propelled along microtubules (MTs) by minus-end-directed and presumably plus-end-directed MT motors. The tracked particles correspond to functional units, since they no longer include a viral envelope, but do include viral matrix protein, Vpr, capsid protein, and reverse transcription activity.
Sodeik
Beate
B
Department of Virology, OE 5230, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30623 Hannover, Germany. Sodeik.Beate@MH-Hannover.de
D021581:Active Transport, Cell Nucleus; D002467:Cell Nucleus / Q000821:virology*; D003600:Cytosol / Q000821:virology*; D004398:Dyneins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D049452:Green Fluorescent Proteins; D006678:HIV / Q000502:physiology*; D006801:Humans; D008164:Luminescent Proteins / Q000378:metabolism; D008870:Microtubules / Q000821:virology; D020409:Molecular Motor Proteins / Q000378:metabolism / Q000821:virology; D012367:RNA, Viral / Q000378:metabolism; D014771:Virion / Q000502:physiology
D008164:Luminescent Proteins; D020409:Molecular Motor Proteins; D012367:RNA, Viral; D049452:Green Fluorescent Proteins; D004398:Dyneins