title: The relationship between nonresponse to hepatitis B vaccine and HLA genotype/haplotype.
abstract: OBJECTIVE
  To study the relationship between the nonresponse to hepatitis B vaccine and HLA genotype/heplotype in Chinese population and provide the evidence for explaining the genetic mechanism of this nonresponse.
  
  
  METHODS
  Our research focused on the relationship between nonresponse to Hepatitis B vaccine and HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 genotype/haplotype in Chinese population, collected from a community in Guangxi Zhuang Autonomous Region. The group specific amplification was employed to characterize 107 individuals' genotype and haplotype of HLA clusters. Different models statistics such as relative risk test, correlation test and linkage disequilibrium analysis were used to analyze the data.
  
  
  RESULTS
  The results showed that there is a linkage disequilibrium between nonresponse to Hepatitis B vaccine and HLA haplotype DR4, 1122 (DRB1 * 0401- 22, 1122)-DR53 (DRB4 * 0101101, 0102/3)-DQB4 (DQB1 * 04).
  
  
  CONCLUSIONS
  In Chinese population, nonresponse to hepatitis B vaccine is highly associated with special HLA haplotye.
authors.affiliation: Department of Epidemiology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.
authors.forename: Mingyue
authors.initials: M
authors.lastname: Li
authors.forename: Rongcheng
authors.initials: R
authors.lastname: Li
authors.forename: Shangzhi
authors.initials: S
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
authors.forename: Xianjia
authors.initials: X
authors.lastname: Zeng
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005838:Genotype; D006683:HLA-DQ Antigens / Q000145:classification / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D059845:HLA-DRB4 Chains; D059847:HLA-DRB5 Chains; D006239:Haplotypes; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D015810:Linkage Disequilibrium
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553505:HLA-DRB1*04:01 antigen; D059826:HLA-DRB3 Chains; D059845:HLA-DRB4 Chains; D059847:HLA-DRB5 Chains; D017325:Hepatitis B Vaccines