Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent.
A number of inhibitors of NF-kappaB signaling arising from our recent syntheses of isopanepoxydone and panepoxydone have been identified. Structure-activity data have been correlated to allow the design and synthesis of an affinity reagent for the isolation and identification of any relevant cellular target.
Shotwell
J Brad
JB
Sterling Chemistry Laboratory, Yale University, New Haven, CT 06520, USA.
Koh
Brian
B
Choi
Hui Won
HW
Wood
John L
JL
Crews
Craig M
CM
D001710:Biotin / Q000031:analogs & derivatives*; D019921:Biotinylation; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D015195:Drug Design; D004591:Electrophoresis, Polyacrylamide Gel; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013329:Structure-Activity Relationship
D019086:Bridged Bicyclo Compounds, Heterocyclic; D007202:Indicators and Reagents; D016328:NF-kappa B; C101349:panepoxydone; D001710:Biotin