A short history of LIM domains (1993-2002): from protein interaction to degradation.
The LIM domain is a cysteine-rich zinc-finger motif found in a large family of proteins. In LIM-homeodomain (LIM-hd) transcription factors and LIM-only (LMO) factors, the LIM domains are responsible for key interactions with co-activators, co-repressors, competitors, and other transcription factors, and are therefore of considerable importance for the regulation of associated transcriptional activity. In this review, the authors describe the progressive discoveries of NLI/Ldb/CLIM, LMO and RLIM, and discuss how the field was very recently updated by the finding that LIM-hd transcriptional activity is controlled by regulated degradation of cofactors and LIM-hd themselves.
Rétaux
Sylvie
S
UPR 2197 Développement, Evolution, Plasticité du Système Nerveux Institut de Neurobiologie Alfred FESSARD, CNRS, GIF-sur-YVETTE, France. Sylvie.Retaux@iaf.cnrs-gif.fr
Bachy
Isabelle
I
D000818:Animals; D005136:Eye Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D060850:LIM-Homeodomain Proteins; D008565:Membrane Proteins; D025941:Protein Interaction Mapping / Q000379:methods; D014157:Transcription Factors
D005136:Eye Proteins; D018398:Homeodomain Proteins; C085473:LHX1 protein, human; D060850:LIM-Homeodomain Proteins; C044539:LIM2 protein, human; D008565:Membrane Proteins; D014157:Transcription Factors