title: Toxicological studies on Stryphnodendron adstringens.
abstract: This study was carried out to determine the acute toxicity of total barbatimão extract (LD(50)) after oral administration to mice, and its effect on certain biochemical parameters in plasma of rats after 30 days of administration. The LD(50) value of the extract was 2699 mg/kg. A daily oral administration of extracts at 800 and 1600 mg/kg doses for 30 days caused a decrease in body weight, thymic involution, and an increase of plasma glucose and aspartate aminotransferase levels in the animals. The results showed that the extract administered in a prolonged period produced toxic effects in the experimental animals.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Maringá, Avenida Colombo, 5790, 87020-900, Maringa, PR, Brazil.
authors.forename: Marcelo Alessandro
authors.initials: MA
authors.lastname: Rebecca
authors.forename: Emy Luiza
authors.initials: EL
authors.lastname: Ishii-Iwamoto
authors.forename: Renata
authors.initials: R
authors.lastname: Grespan
authors.forename: Roberto Kenji Nakamura
authors.initials: RK
authors.lastname: Cuman
authors.forename: Silvana Martins
authors.initials: SM
authors.lastname: Caparroz-Assef
authors.forename: João Carlos Palazzo de
authors.initials: JC
authors.lastname: Mello
authors.forename: Ciomar Aparecida
authors.initials: CA
authors.lastname: Bersani-Amado
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae; D007668:Kidney / Q000187:drug effects; D007677:Kidney Function Tests; D007928:Lethal Dose 50; D007962:Leukocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D010947:Plants, Toxic / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts