title: Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis.
abstract: We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.
authors.affiliation: Tomsk State Pedagogical University.
authors.forename: D S
authors.initials: DS
authors.lastname: Ugdyzhekova
authors.forename: A V
authors.initials: AV
authors.lastname: Krylatov
authors.forename: N A
authors.initials: NA
authors.lastname: Bernatskaya
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: R
authors.initials: R
authors.lastname: Mechoulam
authors.forename: R G
authors.initials: RG
authors.lastname: Pertwee
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000819:agonists / Q000378:metabolism*
chemical_list: D002316:Cardiotonic Agents; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D013759:Dronabinol; C062018:HU 211