Bacterial clearance after total splenectomy and splenic autotransplantation in rats.
Wistar rats submitted to isolated total splenectomy or total splenectomy combined with splenic autotransplantation were inoculated with 99mtechnetium-labeled Escherichia coli. Measurement of isotope uptake in the organs of the mononuclear phagocytic system showed a greater bacterial bloodstream clearance in rats with splenic autotransplantation. Although uptake of bacteria in the spleen was higher in the control group, the number of bacteria remaining in the bloodstream did not differ between groups. These results indicate that splenic autotransplantation preserves the phagocytic function of the spleen.
Marques
Ruy Garcia
RG
Department of General Surgery, Rio de Janeiro State University, Rua Clovis Salgado 280/104 Recreio, 22795-230, Rio de Janeiro, RJ, Brazil. rmarques@uerj.br
Petroianu
Andy
A
de Oliveira
Márcia Betânia Nunes
MB
Bernardo-Filho
Mário
M
Boasquevisque
Edson Mendes
EM
Portela
Margareth Crisóstomo
MC
D000818:Animals; D001770:Blood Bactericidal Activity; D004926:Escherichia coli / Q000302:isolation & purification*; D005260:Female; D008221:Lymphoid Tissue / Q000382:microbiology; D008297:Male; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000637:transplantation*; D013156:Splenectomy; D014182:Transplantation, Autologous