Approach to lipoprotein management in 2001 National Cholesterol Guidelines.
In 2001 the National Cholesterol Education Program (NCEP) released its Adult Treatment Panel (ATP) III report. This was an evidence-based report that upgraded cholesterol management guidelines. The update was made possible by a series of large, cholesterol-lowering clinical trials. These trials demonstrated strongly the efficacy and safety of cholesterol reduction in both primary and secondary prevention of coronary heart disease (CHD). The major recommendations of the report were several. Low-density lipoprotein (LDL) cholesterol continued to be identified as the major target of cholesterol-lowering therapy. However, more emphasis was given to HDL cholesterol and triglycerides as important targets for management. The concept of CHD risk equivalents was introduced. A CHD risk equivalent represents an absolute risk for future CHD events equal to that in persons with established CHD. Diabetes was identified as a CHD risk equivalent, requiring more intensive LDL-lowering therapy. Finally, the report placed more emphasis on the metabolic syndrome as a major, multiplex risk factor requiring increased clinical attention.
Grundy
Scott M
SM
Center for Human Nutrition and Departments of Clinical Nutrition and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9052, USA. scott.grundy@utsouthwestern.edu
D008078:Cholesterol, LDL / Q000187:drug effects / Q000378:metabolism; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism / Q000517:prevention & control; D019317:Evidence-Based Medicine; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000378:metabolism / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008074:Lipoproteins / Q000187:drug effects* / Q000378:metabolism; D017410:Practice Guidelines as Topic; D014481:United States / Q000453:epidemiology
D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D008074:Lipoproteins