[The expression of transforming growth factor alpha, beta 1 in hyperplastic tissue after endoscopic polypectomy and the effect of corticosteroid].
OBJECTIVE
To study the expression of transforming growth factor alpha, beta 1 in hyperplastic tissue after endoscopic polypectomy and the effect of corticosteroid.


METHODS
Forty patients with nasal polyps were divided into two groups randomly: corticosteroid group (n = 20) with topical application of Budesonide (BUD, 400 micrograms/d) after endoscopic polypectomy and control group (n = 20) without corticosteroid after surgery. The hyperplastic tissues in operative cavity obtained in the 1st and 8th weeks after operation were studied with HE staining and immunohistochemistry technique respectively.


RESULTS
Morphological changes of hyperplastic tissue after endoscopic polypectomy included pseudostratified epithelium, highly edematous lamina proper and inflammatory cells infiltration, in which the main infiltrative cells were eosinophils (67.5%). Transforming growth factor alpha(TGF alpha) protein was highly expressed in epithelial cells, grand cells and inflammatory cells in the hyperplastic tissue. Transforming growth factor beta 1 (TGF beta 1) protein was highly expressed in inflammatory cells in the hyperplastic tissue. The expression of TGF alpha and beta 1 was significantly decreased after topical BUD spray (P < 0.01, 0.05).


CONCLUSIONS
Transforming growth factor alpha and beta 1 may play an important role in the formation and recurrence of nasal polyps.
Chen
Fuquan
F
Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
Huang
Weiguo
W
Qiao
Li
L
Jiang
Hongyan
H
Qiu
Jianhua
J
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D019819:Budesonide / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology*; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016211:Transforming Growth Factor alpha / Q000096:biosynthesis* / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D016211:Transforming Growth Factor alpha; D016212:Transforming Growth Factor beta; D019819:Budesonide