title: Diet during pregnancy and total antioxidant capacity in maternal and umbilical cord blood.
abstract: OBJECTIVE
  To evaluate the longitudinal trend of total antioxidant capacity (ToAC) in a group of pregnant women and the relationship with their food habits and ToAC of their newborns.
  
  
  METHODS
  ToAC of 12 pregnant women and of umbilical cord blood was determined by means of the oxygen radical absorbance capacity method; mothers' diet was assessed by the dietary history method.
  
  
  RESULTS
  Mothers' oxygen radical absorbance capacity values decreased slightly from the first (5.41 +/- 0.28 mmol/l trolox eq.) to the third (5.23 +/- 0.26 mmol/l trolox eq.) trimester of pregnancy, but significantly at delivery (5.06 +/- 0.17 mmol/l trolox eq., p < 0.05 vs. the first, second and third trimesters). Oxygen radical absorbance capacity values of umbilical cord blood (4.87 +/- 0.24 mmol/l trolox eq.) correlated with mothers' values in the third trimester (r = 0.86; p = 0.004) of pregnancy and at delivery (r = 0.87; p = 0.0002). The mothers' diet was rather poor in fruit and vegetables and did not change throughout pregnancy.
  
  
  CONCLUSIONS
  The lowering values of ToAC observed during pregnancy may be a physiological trend or a transient imbalance between higher antioxidant requirements and intake which reflects on newborns' ToAC. Nevertheless, efforts should be made to improve dietary habits in pregnancy in order to optimize the ToAC of mothers and newborns.
authors.affiliation: Nutrition Section of Department of Internal Medicine, University of Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Alberti-Fidanza
authors.forename: G C
authors.initials: GC
authors.lastname: Di Renzo
authors.forename: G
authors.initials: G
authors.lastname: Burini
authors.forename: G
authors.initials: G
authors.lastname: Antonelli
authors.forename: G
authors.initials: G
authors.lastname: Perriello
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D004032:Diet; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters / Q000097:blood
chemical_list: D000975:Antioxidants