title: Prophylactic effect of mycobacterium bovis BCG vaccination against osteomyelitis in children with Mycobacterium ulcerans disease (Buruli Ulcer).
abstract: Mycobacterium ulcerans disease, or Buruli ulcer (BU), causes significant morbidity in West Africa. In 233 consecutive, laboratory-confirmed samples from BU patients in Benin whose Mycobacterium bovis BCG scar status was known, 130 children (<15 years old) and 75 adults had a neonatal BCG vaccination scar. Of 130 children with BCG scars, 10 (7.7%) had osteomyelitis, while 3 of 9 children without BCG scars (33.3%) had osteomyelitis. Our observations support the conclusion that having a BCG vaccination scar provides significant protection against M. ulcerans osteomyelitis in children with BU disease.
authors.affiliation: Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium. portaels@itg.be
authors.forename: F
authors.initials: F
authors.lastname: Portaels
authors.forename: J
authors.initials: J
authors.lastname: Aguiar
authors.forename: M
authors.initials: M
authors.lastname: Debacker
authors.forename: C
authors.initials: C
authors.lastname: Steunou
authors.forename: C
authors.initials: C
authors.lastname: Zinsou
authors.forename: A
authors.initials: A
authors.lastname: Guédénon
authors.forename: W M
authors.initials: WM
authors.lastname: Meyers
mesh_terms: D001500:BCG Vaccine / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009165:Mycobacterium Infections, Nontuberculous / Q000517:prevention & control*; D019911:Mycobacterium ulcerans; D010019:Osteomyelitis / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D001500:BCG Vaccine