Prion diseases: a dual view of the prion hypothesis as seen from a distance.
We review the historical background and principles of the prion theory in its current shape. We showed that most of data may be still interpreted dually according to the protein only hypothesis and according to the theory in which additional component is necessary to comprise the infectivity. The enormous impact of structural biological studies is also stressed.
Liberski
Paweł P
PP
Laboratory of Electron Microscopic and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Department of Neurosurgery, Polish Mother Memorial Hospital, Łódź, Poland. ppliber@csk.am.lodz.pl.
Jaskólski
Mariusz
M
D000818:Animals; D006041:Goats; D006801:Humans; D007729:Kuru / Q000473:pathology / Q000635:transmission; D009154:Mutation; D010641:Phenotype; D017096:Prion Diseases / Q000235:genetics / Q000473:pathology / Q000635:transmission*; D011328:Prions / Q000235:genetics* / Q000472:pathogenicity; D011487:Protein Conformation; D012608:Scrapie / Q000473:pathology / Q000635:transmission
D011328:Prions