title: Designing randomised trials: both large and small trials are needed.
authors.affiliation: Medical Research Council Clinical Trials Unit, London, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Stenning
authors.forename: M K B
authors.initials: MK
authors.lastname: Parmar
mesh_terms: D003131:Combined Modality Therapy; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D020380:Needs Assessment; D009369:Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic / Q000592:standards* / Q000639:trends; D012107:Research Design / Q000592:standards* / Q000639:trends; D018401:Sample Size; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D006113:United Kingdom