title: Biochemical changes of saliva in tobacco chewers tobacco smokers, alcohol consumers, leukoplakia and oral cancer patients.
abstract: Normal salivary function is considered to be critical for the maintenance of healthy oral mucosa. Oral fluids provide an easily available non-invasive for the diagnosis of a wide range of diseases and clinical situations. The present study evaluated the variations in the biochemical constituents of saliva of leukoplakia and oral cancer patients when compared with that of the control group. 90 individuals were grouped into 6 categories with 15 individuals in each group. The groups included individuals without tobacco or alcohol habits, tobacco smokers, tobacco chewers, alcohol consumers, leukoplakia and oral cancer patients. There was significant alteration in the salivary biochemical composition of leukoplakia and oral cancer patients which could be attributed to the impairment of salivary gland function caused by tobacco and alcohol usage or by the disease process itself.
authors.affiliation: Department of Oral Pathology, Bichemistry Molecular Biology, Meenakshi Ammal Dental College, Madras University, Chennai, India.
authors.forename: K P
authors.initials: KP
authors.lastname: Girja
authors.forename: B S
authors.initials: BS
authors.lastname: Sundharam
authors.forename: P A
authors.initials: PA
authors.lastname: Krishnan
authors.forename: C S S
authors.initials: CS
authors.lastname: Devi
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D000681:Amylases / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007972:Leukoplakia, Oral / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry*; D011188:Potassium / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012907:Smoking / Q000378:metabolism*; D012964:Sodium / Q000032:analysis; D013223:Statistics as Topic; D014030:Tobacco, Smokeless / Q000378:metabolism*
chemical_list: D012471:Salivary Proteins and Peptides; D012964:Sodium; D000681:Amylases; D011188:Potassium