Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives.
Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N(4)-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.
Bharti
Neelam
N
Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.
Husain
Kakul
K
Gonzalez Garza
M T
MT
Cruz-Vega
Delia E
DE
Castro-Garza
J
J
Mata-Cardenas
Benito D
BD
Naqvi
Fehmida
F
Azam
Amir
A
D000447:Aldehydes / Q000737:chemistry* / Q000494:pharmacology; D000588:Amines / Q000737:chemistry; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004748:Entamoeba histolytica / Q000187:drug effects; D016829:Giardia lamblia / Q000187:drug effects; D020128:Inhibitory Concentration 50; D021261:Parasitic Sensitivity Tests; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects
D000447:Aldehydes; D000588:Amines; D000981:Antiprotozoal Agents; D013438:Sulfhydryl Compounds; D013882:Thiosemicarbazones