The role of bacterial virulence and host factors in patients with Escherichia coli bacteremia who have acute cholangitis or upper urinary tract infection.
We studied the pathogenic role of host and Escherichia coli virulence factors in the development of E. coli bacteremia in patients with acute cholangitis (AC) or upper urinary tract infection (UTI). Isolates recovered from 75 adult patients consecutively admitted to the hospital with E. coli bacteremia caused by AC (n=24) or upper UTI (n=51) were evaluated, as were 30 fecal strains isolated from healthy control individuals. Virulence genes of E. coli were detected by polymerase chain reaction analysis, including papG genes (classes I-III), sfa/foc, fimH, afa, hlyA, cnf1, and iutA. Our results show that biliary tract obstruction and urinary tract obstruction are important host factors for the development of E. coli bacteremia in patients with AC and upper UTI, respectively. With regard to E. coli virulence factors, the papG class II gene might play a more important role in the development of E. coli bacteremia in patients with upper UTI than in those with AC.
Wang
Ming-Cheng
MC
Department of Internal Medicine, National Cheng Kung University Medical College, Tainan, 70428, Taiwan, Republic of China.
Tseng
Chin-Chung
CC
Chen
Chiung-Yu
CY
Wu
Jiunn-Jong
JJ
Huang
Jeng-Jong
JJ
D000208:Acute Disease; D018829:Adhesins, Bacterial / Q000235:genetics; D016470:Bacteremia / Q000209:etiology / Q000382:microbiology*; D002761:Cholangitis / Q000150:complications*; D004926:Escherichia coli / Q000235:genetics / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000209:etiology / Q000382:microbiology; D005260:Female; D036781:Fimbriae Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014552:Urinary Tract Infections / Q000150:complications*; D014774:Virulence / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics*
D018829:Adhesins, Bacterial; D037521:Virulence Factors; D036781:Fimbriae Proteins