Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up study.
We investigated whether the caudate nuclei volume (CNV) of 15 first episode psychosis patients increased after 5 years of treatment with either atypical antipsychotics or low doses of typical antipsychotics. Caudate volumes were measured from magnetic resonance imaging (MRI) scans in 15 patients and 10 healthy controls. Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment.
Tauscher-Wisniewski
Sitra
S
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada. sitra.tauscher-wisniewski@akh-wien.ac.at
Tauscher
Johannes
J
Logan
Jeff
J
Christensen
Bruce K
BK
Mikulis
David J
DJ
Zipursky
Robert B
RB
D000328:Adult; D000375:Aging / Q000502:physiology*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002421:Caudate Nucleus / Q000002:abnormalities*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000188:drug therapy
D014150:Antipsychotic Agents