Renal hemodynamics during carbon dioxide pneumoperitoneum: an experimental study in pigs.
BACKGROUND
Laparoscopic living donor nephrectomy is increasingly being performed, although the effects of carbon dioxide pneumoperitoneum (CO2 PP) on renal function and hemodynamics and the levels of vasopressin are not well studied.


METHODS
Renal blood flow, renal venous pressure, urine output, and vasopressin concentrations in renal venous blood were measured in pigs subjected to 12 mmHg of CO2 PP for 150 min.


RESULTS
Renal blood flow was decreased at induction of PP and increased during the first 30 min after exsufflation. Renal venous pressure was increased during PP. There was indirect evidence of a decrease in urine output during PP. No changes in renal venous vasopressin concentrations were seen.


CONCLUSIONS
A CO2 PP of 12 mmHg causes changes in renal hemodynamics and urine output. No changes in vasopressin levels were seen in this pig model, suggesting that other explanations for the observed changes must be sought.
Lindberg
F
F
Department of Surgery, Skellefteå Hospital, 931 86 Skellefteå, Sweden. 0910.51345@telia.com
Bergqvist
D
D
Björck
M
M
Rasmussen
I
I
D000818:Animals; D002245:Carbon Dioxide / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics; D007668:Kidney / Q000098:blood supply / Q000502:physiology*; D008297:Male; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D012079:Renal Circulation; D013552:Swine; D014556:Urine; D014667:Vasopressins / Q000097:blood*; D014690:Venous Pressure
D014667:Vasopressins; D002245:Carbon Dioxide