title: Autoimmune hemolytic anemia in Philadelphia positive chronic myeloid leukemia with t(7;14) anomaly after 5 years of interferon alpha treatment.
abstract: A 41-year-old woman, Philadelphia positive chronic myeloid leukemia patient, had progressive decline in hemoglobin levels. She had been receiving interferon alpha treatment for five years. Autoimmune hemolytic anemia was diagnosed. Subsequent bone marrow examination revealed translocation t(7;14). She was placed on prednisone treatment. The patient responded to prednisone as treatment for the hemolytic process. The result of a direct Coombs' test remained positive. The patient died shortly after the diagnosis of autoimmune hemolytic anemia. Autoimmune hemolytic anemia should be considered in the evaluation of chronic myeloid leukemia patients with a sudden decrease in hemoglobin levels.
authors.affiliation: Kirikkale University Medical School, Department of Internal Medicine, Turkey. dckoksal@hotmail.com
authors.forename: Aydin
authors.initials: A
authors.lastname: Köksal
authors.forename: Düzgün
authors.initials: D
authors.lastname: Ozatli
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Haznedaroğlu
authors.forename: Asuman
authors.initials: A
authors.lastname: Sunguroğlu
authors.forename: Sema
authors.initials: S
authors.lastname: Karakuş
authors.forename: Yahya
authors.initials: Y
authors.lastname: Büyükaşik
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000209:etiology*; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D016898:Interferon-alpha