title: The language of genes.
abstract: Linguistic metaphors have been woven into the fabric of molecular biology since its inception. The determination of the human genome sequence has brought these metaphors to the forefront of the popular imagination, with the natural extension of the notion of DNA as language to that of the genome as the 'book of life'. But do these analogies go deeper and, if so, can the methods developed for analysing languages be applied to molecular biology? In fact, many techniques used in bioinformatics, even if developed independently, may be seen to be grounded in linguistics. Further interweaving of these fields will be instrumental in extending our understanding of the language of life.
authors.affiliation: Bioinformatics Division, Genetics Research, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA. david_b_searle@gsk.com
authors.forename: David B
authors.initials: DB
authors.lastname: Searls
mesh_terms: D019295:Computational Biology / Q000379:methods* / Q000639:trends; D019143:Evolution, Molecular; D005796:Genes / Q000235:genetics*; D016678:Genome; D006801:Humans; D008037:Linguistics / Q000379:methods*; D008957:Models, Genetic; D008967:Molecular Biology / Q000379:methods* / Q000639:trends; D009696:Nucleic Acids / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014825:Vocabulary
chemical_list: D009696:Nucleic Acids; D011506:Proteins