title: Gadodiamide as an alternative contrast agent during angioplasty in patients with contraindications to iodinated media.
abstract: OBJECTIVE
  To evaluate gadodiamide as an alternative contrast agent for peripheral and renal angioplasty in patients with contraindications to iodinated contrast media.
  
  
  METHODS
  Seventeen patients (10 men; mean age 74 years, range 68-83) with contraindication to iodinated contrast media were given gadodiamide as the contrast agent during peripheral and renal intra-arterial digital subtraction angiography (DSA) and subsequent percutaneous interventions (balloon angioplasty, stent placement).
  
  
  RESULTS
  The mean volume of gadodiamide used was 136 +/- 46 mL (range 60-200). No serious side effects were observed, especially no change in renal or thyroid function; no exanthema or other allergic reactions were noted. In patients without renal artery intervention, serum creatinine at discharge remained unchanged (2.57 +/- 1.43 mg/dL to 2.40 +/- 1.28 mg/dL, p=NS). In patients undergoing angioplasty/stenting of renal artery stenoses, serum creatinine decreased significantly from 3.53 +/- 1.75 mg/dL to 2.36 +/- 1.15 mg/dL (p<0.01). All but 1 intervention was successful. Using a simple scoring system, 2 judges blinded to the contrast agent graded the quality of the peripheral DSAs as "good," whereas renal DSA images were only "sufficient."
  
  
  CONCLUSIONS
  For patients with contraindications to iodinated materials, gadodiamide may be a suitable alternative for renal or peripheral DSA followed by angioplasty.
authors.affiliation: Department of Angiology, Herz-Zentrum Bad Krozingen, Germany. thomas.zeller@herzzentrum.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Zeller
authors.forename: Christian
authors.initials: C
authors.lastname: Müller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Frank
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Bürgelin
authors.forename: Lutz
authors.initials: L
authors.lastname: Sinn
authors.forename: Barbara
authors.initials: B
authors.lastname: Horn
authors.forename: Peter C
authors.initials: PC
authors.lastname: Flügel
authors.forename: Helmut
authors.initials: H
authors.lastname: Roskamm
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D000800:Angioplasty, Balloon; D019917:Blood Vessel Prosthesis Implantation; D000075202:Contraindications; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D017613:Iodine Compounds; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D015607:Stents; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology
chemical_list: D003287:Contrast Media; D017613:Iodine Compounds; C064925:gadodiamide; D019786:Gadolinium DTPA