title: Osteoprotegerin, RANK, RANKL.
abstract: Osteoprotegerin, RANK (Receptor Activator of Nuclear factor kappa B) and RANKL (Receptor Activator of Nuclear faktor kappa B ligand) became the aim of intensive research. RANK is considered as a hematopoietic surface receptor controlling osteoclastogenesis and calcium metabolism. RANKL may promote osteoresorption by induction of cathepsin K gene expression. The present paper summarizes the most significant data in osteoprotegerin, RANK and RANKL problems obtained.
authors.affiliation: Department of Laboratory Medicine and Internal Medicine, Hospital Sternberk.
authors.forename: D
authors.initials: D
authors.lastname: Stejskal
authors.forename: J
authors.initials: J
authors.lastname: Bartek
authors.forename: R
authors.initials: R
authors.lastname: Pastorková
authors.forename: V
authors.initials: V
authors.lastname: Růzicka
authors.forename: I
authors.initials: I
authors.lastname: Oral
authors.forename: D
authors.initials: D
authors.lastname: Horalík
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D010010:Osteoclasts / Q000502:physiology*; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor
chemical_list: D002352:Carrier Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human