title: Chemical and anti-platelet constituents from Formosan Zanthoxylum simulans.
abstract: A pyrrole alkaloid, pyrrolezanthine [5-hydroxymethyl-1-[2-(4-hydroxyphenyl)-ethyl]-1H-pyrrole-2-carbaldehyde]; a lignan, (-)-simulanol [4- [3-hydroxymethyl-5-((E)-3-hydroxypropenyl)-7-methoxy-2,3-dihydrobenzofuran-2-yl]-2,6-dimethoxy-phenol] and a monocyclic gamma-pyrone, zanthopyranone [3,5-dimethoxy-2-methyl-pyran-4-one], together with 28 known compounds were isolated from the stem wood of Formosan Zanthoxylum simulans. Their structures were determined through spectral analyses. Among the isolates, 11 compounds showed anti-platelet aggregation activity in vitro.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Republic of, Taiwan, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Yang
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Che-Ming
authors.initials: CM
authors.lastname: Teng
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Chang
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D005663:Furans; D017705:Lignans; D010636:Phenols; D010975:Platelet Aggregation Inhibitors; D011714:Pyrans; D011753:Pyrones; D011758:Pyrroles; C473505:pyrrolezanthine; C473506:simulanol; C473507:zanthopyranone