title: Synthesis and biological evaluation of new mannose 6-phosphate analogues.
abstract: Three new analogues of mannose 6-phosphate (M6P)--a sulphate and two carboxylates--have been synthesized and their affinity toward the M6P/IGFII receptor evaluated by affinity column chromatography. These compounds display strong binding to the receptor and therefore are new M6P analogues which may find some dermatological applications, for example healing of post-surgical scars.
authors.affiliation: Laboratoire de Chimie Biomoléculaire (UMR 5032), Université Montpellier II, Ecole Nationale Supérieure de Chimie de Montpellier, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Vidal
authors.forename: Marcel
authors.initials: M
authors.lastname: Garcia
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montero
authors.forename: Alain
authors.initials: A
authors.lastname: Morère
mesh_terms: D002847:Chromatography, Agarose; D016503:Drug Delivery Systems; D008247:Lysosomes; D008360:Mannosephosphates / Q000138:chemical synthesis* / Q000378:metabolism*; D011485:Protein Binding; D017527:Receptor, IGF Type 2 / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; C027693:mannose-6-phosphate