Omega-3 fatty acids to augment cancer therapy.
The results of animal studies have demonstrated that the consumption of omega-3 fatty acids can slow the growth of cancer xenografts, increase the efficacy of chemotherapy and reduce the side effects of the chemotherapy or of the cancer. Molecular mechanisms postulated to contribute to the multiple benefits of omega-3 fatty acids include 1) suppressing the expression of cyclooxygenase-2 in tumors, thus decreasing proliferation of cancer cells and reducing angiogenesis in the tumor; 2) decreasing the expression of AP-1 and ras, two oncogenes implicated in tumor promotion; 3) inducing differentiation of cancer cells; 4) suppressing nuclear factor-kappaB activation and bcl-2 expression, thus allowing apoptosis of cancer cells; and 5) reducing cancer-induced cachexia. It seems reasonable to assume that after appropriate cancer therapy, consumption of omega-3 fatty acids might slow or stop the growth of metastatic cancer cells, increase longevity of cancer patients and improve their quality of life.
Hardman
W Elaine
WE
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA. hardmawe@pbrc.edu
D000818:Animals; D002454:Cell Differentiation; D004041:Dietary Fats / Q000008:administration & dosage / Q000627:therapeutic use*; D015777:Eicosanoids / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D008938:Mitosis; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D012307:Risk Factors; D015996:Survival Rate
D004041:Dietary Fats; D015777:Eicosanoids; D004967:Estrogens; D015525:Fatty Acids, Omega-3