title: Rapid synthesis of a glycosylphosphatidylinositol-based malaria vaccine using automated solid-phase oligosaccharide synthesis.
abstract: Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Hewitt
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Snyder
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
mesh_terms: D002240:Carbohydrate Sequence; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis*; D017780:Malaria Vaccines / Q000138:chemical synthesis*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis*
chemical_list: D017261:Glycosylphosphatidylinositols; D017780:Malaria Vaccines; D009844:Oligosaccharides