Doxorubicin modulates biological effects of ATP in bone marrow cells in vitro.
ATP activity in mouse bone marrow cells was studied in in vitro experiments. ATP in physiological and supraphysiological concentrations stimulated blebbing of the plasma membrane. Subacute administration of doxorubicin (inductor of oxidative stress) decreased cell sensitivity to ATP, which corresponded to changes in membrane lipid peroxidation.
Uspenskaya
Yu A
YA
Department of Anatomy and Physiology of Agricultural Animals, Krasnoyarsk State Agrarian University.
Egorova
A B
AB
Nefedov
V P
VP
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism*; D004317:Doxorubicin / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D008858:Microscopy, Phase-Contrast; D009336:Necrosis; D018384:Oxidative Stress; D013997:Time Factors
D000970:Antineoplastic Agents; D004317:Doxorubicin; D000255:Adenosine Triphosphate