Multiple endocrine disorders and Rathke's cleft cyst with Klinefelter's syndrome: a case report.
A 46-year-old Japanese male was admitted for the evaluation of severe hypertension. He was obese and had a eunuchoidal body habitus. Chromosomal analysis revealed a 46, XY/47, XXY karyotype. Serum LH, FSH and testosterone levels were low, indicating hypogonadotropic hypogonadism. Endocrinological dynamic tests disclosed presence of hypothalamic panhypopituitarism, partial diabetes insipidus, type 2 diabetes mellitus and low renin essential hypertension. Brain computed tomography and magnetic resonance imaging revealed intra- and extrasellar masses. Histological examination of the tissue obtained at transsphenoidal surgery showed a Rathke's cleft cyst (RCC). To the best of our knowledge, this is the first case report of mosaic Klinefelter's syndrome accompanied by symptomatic RCC, type 2 diabetes mellitus and low renin essential hypertension.
Gotoh
Mitsuhiro
M
Department of Internal Medicine, Yanagawa Municipal Hospital, Fukushima, Japan.
Nakano
Junko
J
Midorikawa
Sanae
S
Niimura
Susumu
S
Ono
Yoshiaki
Y
Mizuno
Kenji
K
D020863:Central Nervous System Cysts / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004700:Endocrine System Diseases / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D012083:Renin / Q000097:blood
D012083:Renin