No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese.
A case-control study was conducted to examine the possible association between digestive tract cancers and p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms in Japanese. Cases were 102 esophageal cancer patients, 144 stomach cancer patients, and 147 colorectal cancer patients, and controls were 241 non-cancer outpatients. The genotype frequencies among controls were 55.3% for p73 GG at position 4, 40.4% for GA, and 4.3% for AA, and 37.7% for p53 ArgArg, 44.4% for ArgPro, and 18.0% for ProPro. No significant differences in the genotype frequencies were observed between the controls and each case group or cases as a whole.
Hamajima
Nobuyuki
N
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. nhamajim@aichi-cc.jp
Matsuo
Keitaro
K
Suzuki
Takashi
T
Nakamura
Tsuneya
T
Matsuura
Akira
A
Hatooka
Shunzo
S
Shinoda
Masayuki
M
Kodera
Yasuhiro
Y
Yamamura
Yoshitaka
Y
Hirai
Takashi
T
Kato
Tomoyuki
T
Tajima
Kazuo
K
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D004067:Digestive System Neoplasms / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics; D005091:Exons; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics; D005787:Gene Frequency; D016147:Genes, Tumor Suppressor; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D025521:Tumor Suppressor Proteins
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins