title: Wnt signaling: a complex issue.
abstract: The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification. Together with other families of secreted factors such as TGF beta s, FGFs, Hedgehog and Notch proteins, Wnt growth factors are crucially implicated in these processes. Here, we will first discuss molecular mechanisms and then consider some biological consequences of Wnt signaling.
authors.affiliation: Fetal and Pediatric Surgical Research Unit, Department of Surgery, University Children's Hospital Zürich, Steinwiesstr. 75, CH-8032 Zürich, Switzerland.
authors.forename: Bart
authors.initials: B
authors.lastname: Hendriks
authors.forename: Ernst
authors.initials: E
authors.lastname: Reichmann
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D003598:Cytoskeletal Proteins; D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins