Finding signals that regulate alternative splicing in the post-genomic era.
Alternative splicing of pre-mRNAs is central to the generation of diversity from the relatively small number of genes in metazoan genomes. Auxiliary cis elements and trans-acting factors are required for the recognition of constitutive and alternatively spliced exons and their inclusion in pre-mRNA. Here, we discuss the regulatory elements that direct alternative splicing and how genome-wide analyses can aid in their identification.
Ladd
Andrea N
AN
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. tcooper@bcm.tmc.edu
Cooper
Thomas A
TA
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D019295:Computational Biology; D004742:Enhancer Elements, Genetic / Q000235:genetics; D005544:Forecasting; D005786:Gene Expression Regulation / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D012322:RNA Precursors / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics
D012322:RNA Precursors; D015534:Trans-Activators