title: Complications and conversions in myeloproliferative disorders: an analysis of 356 cases.
abstract: OBJECTIVE
  To investigate the complications and conversions in myeloproliferative disorders (MPD).
  
  
  METHODS
  Three hundred and fifty six patients with MPD were reviewed, including 78 with etiologic thrombocythemia (ET), 93 with primary myelofibrosis (MF), 185 with polythythemia vera (PV). The clinical observation, follow-up, analysis with SPSS statistic software were performed.
  
  
  RESULTS
  Out of the 356 cases, 101 (28.5%) developed thromboembolic events, 81 (22.8%) hemorrhage, 60 (16.9%) hypertension, 20 (5.6%) coronary heart disease, 3 (0.8%) hemolysis and 1 (0.3%) gastrointestinal ulcer, 2 (0.6%) calculus and 1 (0.3%) bone marrow necrosis. Twenty four patients (6.7%) developed MF (9 in ET, 15 in PV), 2 (0.6%) erythrocytosis (1 in ET, 1 in MF), 3 (0.8%) thrombocythemia (all in PV), 5 (1.4%) acute leukemia (2 in ET, 3 in MF) and 1 (0.3%) multiple myeloma (in ET). Eleven cases (3.1%) died, 5 (1.4%) from acute leukemia, 2 (0.6%) fatal hemorrhages, 1 (0.3%) each myocardial infarction and infectious shock, 2 (0.6%) unknown causes.
  
  
  CONCLUSIONS
  Embolism and bleeding were the main complications in MPD. Conversions among ET, MF and PV hematological malignancies could occur.
authors.affiliation: Institute of Hematology, CAMS and PUMC, Tianjin 300020, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Anlan
authors.initials: A
authors.lastname: Zuo
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Liu
authors.forename: Bingcheng
authors.initials: B
authors.lastname: Liu
authors.forename: Changlai
authors.initials: C
authors.lastname: Hao
authors.forename: Lihong
authors.initials: L
authors.lastname: Wang
authors.forename: Xueli
authors.initials: X
authors.lastname: Zhou
authors.forename: Linsheng
authors.initials: L
authors.lastname: Qian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000401:mortality