Telomeres: the molecular events driving end-to-end fusions.
Recent data indicate that loss of the protective telomeric capping function leads to active degradation of the telomeric G-strand overhang and DNA ligase IV-mediated non-homologous end joining. These molecular events may contribute to genomic instability early in tumorigenesis.
Bertuch
Alison A
AA
Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. abertuch@bcm.tmc.edu
D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000378:metabolism*; D016615:Telomere
D011088:DNA Ligases; D000072481:DNA Ligase ATP