Strain relaxation of fibroblasts in the marginal periodontium is the common trigger for alveolar bone resorption: a novel hypothesis.
In summary, the present commentary proposes a hypothesis that alveolar bone remodeling and bone loss in periodontitis, periodontal surgery, and in orthodontic tooth movement is triggered by a common "strain relaxation" signaling pathway of gingival and periodontal fibroblasts. The abrupt splitting, degradation, or relaxation of collagen fibers in the marginal periodontium produces a "strain relaxation" signal in the local fibroblasts which reside on these fibers, activating an ECM-integrin-cytoskeleton pathway. A cascade of cellular reactions which lead to osteoclastic bone resorption starting on the inner aspect (periodontal) of the alveolar bone then persists. A novel therapeutic approach is suggested here by using locally delivered drugs intervening in the cell contractile apparatus.
Binderman
Itzhak
I
Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
Bahar
Hila
H
Yaffe
Avinoam
A
D016301:Alveolar Bone Loss / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003094:Collagen / Q000737:chemistry; D003799:Dental Stress Analysis; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D010518:Periodontitis / Q000503:physiopathology*; D010519:Periodontium / Q000166:cytology*; D015398:Signal Transduction; D013314:Stress, Mechanical; D013601:T-Lymphocytes / Q000502:physiology; D013718:Tensile Strength; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D061965:Matrix Metalloproteinase Inhibitors; D003094:Collagen; D020782:Matrix Metalloproteinases; D013752:Tetracycline