Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis.
OBJECTIVE
To assess the influence of interleukin-8 (IL-8), epithelial cell-derived neutrophil-activating peptide (ENA-78), and regulated upon activation normal T cell expressed and secreted (RANTES) gene polymorphisms in the susceptibility and clinical expression of patients fulfilling classification criteria for Henoch-Schönlein purpura (HSP).


METHODS
Fifty patients (25 men) from Northwest Spain with primary cutaneous vasculitis classified as HSP according to proposed criteria were studied. All patients were required to have had at least 2 years' followup. Patients and ethnically matched controls were genotyped for IL-8, ENA-78, and RANTES gene polymorphisms.


RESULTS
No allele or genotype differences between patients fulfilling HSP classification criteria and controls were observed for any of the chemokines. However, a significantly increased frequency of allele A of the IL-8 gene polymorphism was found in patients with HSP who developed renal manifestations compared with patients without renal involvement (p = 0.02; pcorr = 0.036). Moreover, the genotype distribution in HSP patients with and without renal involvement showed statistically significant differences (p = 0.02).


CONCLUSIONS
In unselected patients with cutaneous vasculitis, carriage of IL-8 allele A influences the susceptibility to renal involvement.
Amoli
Mahsa M
MM
ARC Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom.
Thomson
Wendy
W
Hajeer
Ali H
AH
Calviño
Maria C
MC
Garcia-Porrua
Carlos
C
Ollier
William E R
WE
Gonzalez-Gay
Miguel A
MA
D000293:Adolescent; D000328:Adult; D018946:Chemokine CCL5 / Q000235:genetics; D054365:Chemokine CXCL5; D019743:Chemokines, CXC; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000235:genetics*; D016209:Interleukin-8 / Q000031:analogs & derivatives* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
C486263:CXCL5 protein, human; D018946:Chemokine CCL5; D054365:Chemokine CXCL5; D019743:Chemokines, CXC; D016209:Interleukin-8