Content of stromal precursor cells in heterotopic transplants of bone marrow in CBA mice of various ages.
Efficiency of colony formation of stromal precursor cells in cultured bone marrow transplants from old (24 month) CBA mice implanted to young (2-month-old) mice almost 3-fold surpassed that in cultured transplants implanted to old recipients. The content of nucleated cells in bone marrow transplants from senescence accelerated mice SAMP increased more than 2-fold, if SAMR mice with normal aging rate were used as the recipients instead of SAMP mice. Bone marrow taken from old and young CBA mice endured the same number of transplantations if the recipient mice were of the same age (5 month). It was concluded that stromal tissue considerably changes with age and is under strict control of the body.
Gorskaya
Yu F
YF
Laboratory of Cell Immunology, Laboratory of Immunology Stromal Control, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Kuralesova
A I
AI
Shuklina
E Yu
EY
Nesterenko
V G
VG
D000375:Aging / Q000502:physiology*; D000818:Animals; D016026:Bone Marrow Transplantation; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism*; D014183:Transplantation, Heterologous