title: In vivo neurochemical monitoring by microdialysis and capillary separations.
abstract: Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis. These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery.
authors.affiliation: Department of Chemistry and Pharmacology, 930 North University, University of Michigan, Ann Arbor 48109-1055, USA. rtkenn@umich.edu
authors.forename: Robert T
authors.initials: RT
authors.lastname: Kennedy
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Watson
authors.forename: William E
authors.initials: WE
authors.lastname: Haskins
authors.forename: David H
authors.initials: DH
authors.lastname: Powell
authors.forename: Robert E
authors.initials: RE
authors.lastname: Strecker
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D019075:Electrophoresis, Capillary; D006801:Humans; D017551:Microdialysis; D009479:Neuropeptides / Q000032:analysis / Q000737:chemistry; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
chemical_list: D009479:Neuropeptides