title: Idiopathic myelofibrosis with prominent postsplenectomy erythroblastosis terminating in acute myeloid transformation.
abstract: Idiopathic myelofibrosis is a myeloproliferative disease with poor prognosis and without sufficient therapy. Acute leukemic transformation occurs in 15% of patients. The authors report the case of a 63 year old myelofibrotic patient treated with splenectomy. During the clinical course they observed unusually prominent and persistent erythroblastosis in the peripherial blood. After a two years long, relatively stable period the disease terminated in acute myeloid leukemia.
authors.affiliation: 1st Department of Internal Medicine, County Hospital, Zala, Hungary. zmk-l-bel@zalaszam.hu
authors.forename: P
authors.initials: P
authors.lastname: Tóth
authors.forename: Z
authors.initials: Z
authors.lastname: Tóth
mesh_terms: D000208:Acute Disease; D002471:Cell Transformation, Neoplastic; D004900:Erythroblasts / Q000473:pathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011086:Polycythemia / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000097:blood* / Q000209:etiology / Q000601:surgery; D013156:Splenectomy