Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane.
Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate-sensitive K+ channel (mitoKATP), is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoKCa) of guinea pig ventricular cells. MitoKCa significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoKCa protected hearts against infarction.
Xu
Wenhong
W
Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Liu
Yongge
Y
Wang
Sheng
S
McDonald
Todd
T
Van Eyk
Jennifer E
JE
Sidor
Agnieszka
A
O'Rourke
Brian
B
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D018999:Charybdotoxin / Q000494:pharmacology; D019610:Cytoprotection; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006439:Hemodynamics; D007425:Intracellular Membranes / Q000378:metabolism*; D017136:Ion Transport; D051036:Large-Conductance Calcium-Activated Potassium Channels; D008929:Mitochondria, Heart / Q000378:metabolism*; D009203:Myocardial Infarction / Q000517:prevention & control*; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000648:ultrastructure; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism*; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism*
D001562:Benzimidazoles; D051036:Large-Conductance Calcium-Activated Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D018999:Charybdotoxin; C086491:NS 1619; D000255:Adenosine Triphosphate; D011188:Potassium; D002118:Calcium