title: Retinal fluorescein contrast arrival time of young patients with the hepatosplenic form of the Schistosomiasis mansoni.
abstract: Schistosoma mansoni is responsible for lesions that can alter the hemodinamic of the portal venous circulation, lung arterial and venous sistemic systems. Therefore, hemodinamic changes in the ocular circulation of mansonic schistosomotic patients with portal hypertension and hepatofugal venous blood flow is also probable. The purpose of this study was to determine the fluorescein contrast arrival time at the retina of young patients with the hepatosplenic form of schistosomiasis, clinically and surgically treated. The control group included 36 non schistosomotic patients, mean age of 17.3 years, and the case group was represented by 25 schistosomotic patients, mean age of 18.2 years, who were cared for at The University Hospital (Federal University of Pernambuco, Brazil), from 1990 to 2001. They underwent digital angiofluoresceinography and were evaluated for the contrast arrival time at the early retinal venous phase of the exam. Both groups were ophthalmologically examined at the same hospital (Altino Ventura Foundation, Recife, Brazil), using the same technique. There was retardation of the retinal contrast arrival time equal or more than 70 sec in the eyes of three schistosomotic patients (12%) and in none of the control group, however, the mean contrast arrival time between the two groups were not statistically different. These findings lend support to the hypothesis that there could be a delay of the eye venous blood flow drainage.
authors.affiliation: Departamento de Cirurgia, Hospital das Clínicas, CCS, Universidade Federal de Pernambuco, Recife, PE, 500670-420, Brasil.
authors.forename: Ana Catarina
authors.initials: AC
authors.lastname: Delgado de Souza
authors.forename: Carlos
authors.initials: C
authors.lastname: Teixeira Brandt
authors.forename: Liana
authors.initials: L
authors.lastname: Ventura
authors.forename: Fernando
authors.initials: F
authors.lastname: Oréfice
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001776:Blood Circulation Time; D016022:Case-Control Studies; D002648:Child; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D019793:Fluorescein / Q000493:pharmacokinetics*; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D012171:Retinal Vessels / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D012555:Schistosomiasis mansoni / Q000378:metabolism / Q000503:physiopathology*; D013158:Splenic Diseases / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D003287:Contrast Media; D019793:Fluorescein