Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway.
Immunomodulating effects of synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) and possible involvement of the sphingomyelin signal transduction pathway in their effects in mouse thymocytes were studied. Vilon produced the most potent comitogenic effect on thymocyte proliferation and modulated comitogenic activity of interleukin-1b. Epithalon was less potent, while Cortagen produced no such effects. Vilon produced a more pronounced stimulatory effect on sphingomyelinase activity in mouse thymocyte membranes compared to Epithalon and Cortagen.
Khavinson
V Kh
VKh
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences.
Rybakina
E G
EG
Malinin
V V
VV
Pivanovich
I Yu
IY
Shanin
S N
SN
Korneva
E A
EA
D000818:Animals; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D013109:Sphingomyelins / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology*
D004151:Dipeptides; D009842:Oligopeptides; D010455:Peptides; D013109:Sphingomyelins; C431545:alanyl-glutamyl-aspartylprolyine; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine