No evidence of de novo amyloidosis in recipients of domino liver transplantation: 12 to 40 (mean 24) month follow-up.
Domino liver transplantation (DLT) has been performed for selected recipients at several centers, but de novo amyloidosis in recipients of livers from patients with familial amyloid polyneuropathy (FAP) remains a serious concern.


OBJECTIVE
To evaluate the occurrence of de novo amyloidosis in recipients of DLT.


METHODS
Seven recipients of FAP livers were followed for clinical and electroneuromyographic signs of FAP and also for de novo amyloid deposition in the gut.


RESULTS
No signs and symptoms of de novo FAP nor any evidence of amyloid deposits in the gut were observed in recipients of DLT after a mean follow-up of 24 [12-40] months.


CONCLUSIONS
Signs and symptoms of FAP do not occur early in recipients of DLT. These livers could therefore be offered to patients suitable for conventional LT, particularly older subjects in whom the event of de novo amyloidosis would seem improbable.
Bittencourt
Paulo Lisboa
PL
Liver Unit, University of São Paulo School of Medicine, Brazil. plbbr@uol.com.br
Couto
Claudia Alves
CA
Leitão
Regina Maria Cubero
RM
Siqueira
Sheila Aparecida
SA
Farias
Alberto Queiroz
AQ
Massarollo
Paulo Celso Bosco
PC
Mies
Sérgio
S
D000328:Adult; D000682:Amyloid / Q000096:biosynthesis*; D028227:Amyloid Neuropathies, Familial / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
D000682:Amyloid