title: Production of interleukin-1 activity of Kupffer cells from mice treated with the acidic mannan fraction of baker's yeast.
abstract: We investigated the production of interleukin-1 (IL-1) activity by Kupffer cells (KC) from mice treated with a neutral mannan fraction (WNM) or an acidic mannan fraction (WAM025) from baker's yeast (Saccharomyces cerevisiae) in vivo and in vitro. The mice administered WAM025 showed an increase in the number of KC and the IL-1 production compared with mice administered WNM. In an in vitro stimulation assay using KC from a normal mouse, it was also found that WAM025 displayed an increase in IL-1 production. Diisopropyl fluorophosphate completely inhibited the production of IL-1 by KC from the mice administered WAM025.
authors.affiliation: Second Department of Hygienic Chemistry, Tohoku Pharmaceutical University,miyagi, Japan. okawa@tohoku-pharm.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Okawa
authors.forename: Kouji
authors.initials: K
authors.lastname: Abe
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Masuko
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D007375:Interleukin-1 / Q000096:biosynthesis*; D007728:Kupffer Cells / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012441:Saccharomyces cerevisiae; D015002:Yeast, Dried / Q000494:pharmacology*
chemical_list: D007375:Interleukin-1; D008351:Mannans