Copper(I) hydride-catalyzed asymmetric hydrosilylation of heteroaromatic ketones.
In situ generation of CuH ligated by Takasago's new nonracemic ligand, DTBM-SEGPHOS, leads to an especially reactive reagent capable of effecting asymmetric hydrosilylation of heteroaromatic (H) ketones under very mild conditions. PMHS serves as an inexpensive source of hydride. Substrate-to-ligand ratios on the order of 2000:1 are employed. [reaction: see text]
Lipshutz
Bruce H
BH
Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, CA 93106, USA. lipshutz@chem.ucsb.edu
Lower
Asher
A
Noson
Kevin
K