New gelatin-based hydrogels via enzymatic networking.
New types of hydrogels have been obtained starting from high bloom purified gelatin A, alone or in mixtures with hyaluronan and with a hyaluronan derivative bearing primary amino groups, by transglutaminase-catalyzed cross-linking. The reticulation process, carried out adopting two different temperature protocols, and the ensuing materials have been characterized in terms of rheologically estimated gel times, equilibrium swelling in water and in phosphate buffer solution (PBS), and rigidity modulus. Main structural and conformational factors governing the physicochemical properties and the possible application of the new hydrogels are discussed.
Crescenzi
Vittorio
V
Department of Chemistry, University La Sapienza, Rome, Italy. vittorio.crescenzi@uniroma1.it
Francescangeli
Andrea
A
Taglienti
Anna
A
D003432:Cross-Linking Reagents; D005780:Gelatin / Q000737:chemistry*; D006820:Hyaluronic Acid; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D011503:Transglutaminases / Q000378:metabolism*; D014783:Viscosity
D003432:Cross-Linking Reagents; D020100:Hydrogels; D005780:Gelatin; D006820:Hyaluronic Acid; D011503:Transglutaminases