TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle.
OBJECTIVE
We performed a case-control study to assess the association between obesity risk and the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene.


METHODS
Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2] and controls (n = 154; BMI < 25 kg/m2) were compared using multivariable logistic regression to control for potential confounders.


RESULTS
A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00-8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people.


CONCLUSIONS
Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.
Marti
A
A
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain. amarti@unav.es
Corbalán
M S
MS
Martínez-Gonzalez
M A
MA
Martinez
J A
JA
D000328:Adult; D016022:Case-Control Studies; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D012044:Regression Analysis; D012307:Risk Factors
D011943:Receptors, Adrenergic, beta