Allergic bronchopulmonary aspergillosis in a lung transplant patient successfully treated with nebulized amphotericin.
A case of allergic bronchopulmonary Aspergillosis (ABPA) complicating lung transplantation for cystic fibrosis is described. Control of ABPA was only achieved with 20 mg of prednisone and 600 mg of itraconazole per day. However, a prompt clinical and physiologic response was observed when nebulized amphotericin was introduced, which allowed prednisone to be reduced to 7.5 mg per day and, in time, all anti-fungal therapy to be withdrawn.
Casey
Paul
P
Department of Respiratory Medicine, Green Lane Hospital, Auckland, New Zealand.
Garrett
Jeff
J
Eaton
Tam
T
D000280:Administration, Inhalation; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis / Q000188:drug therapy*; D003550:Cystic Fibrosis / Q000601:surgery; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D005938:Glucocorticoids; D017964:Itraconazole; D000666:Amphotericin B; D011241:Prednisone