Recent developments in amperometric detection for microchip capillary electrophoresis.
The interest in microfluidic devices has increased considerably over the past decade due to the numerous advantages of working within a miniature, microfabricated format. This review focuses on recent advances in coupling amperometric detection with microchip capillary electrophoresis (CE). Advances in electrochemical cell design, isolation of the detector from the separation field, and integration of both pre- and postseparation reaction chambers are discussed. The use of microchip CE with amperometric detection for enzyme/immunoassays, clinical and environmental assays, and the determination of neurotransmitters is described.
Vandaveer
Walter R
WR
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Pasas
Stephanie A
SA
Martin
R Scott
RS
Lunte
Susan M
SM
D019963:Clinical Chemistry Tests; D019075:Electrophoresis, Capillary / Q000295:instrumentation* / Q000379:methods; D004785:Environmental Pollutants / Q000032:analysis; D007118:Immunoassay; D008832:Microchemistry / Q000295:instrumentation; D008839:Microelectrodes; D018377:Neurotransmitter Agents / Q000032:analysis
D004785:Environmental Pollutants; D018377:Neurotransmitter Agents