title: Endocytosis: driving membranes around the bend.
abstract: When a nascent vesicle buds, the membrane must curve. Several mechanisms have been proposed for curvature creation or stabilization. Structural analysis of the ENTH domain of the endocytic protein epsin has suggested a new mechanism, in which the ENTH domain pushes its way into membranes, thus bending them into shape.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. james.hurley@nih.gov
authors.forename: James H
authors.initials: JH
authors.lastname: Hurley
authors.forename: Beverly
authors.initials: B
authors.lastname: Wendland
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D048429:Cell Size; D004705:Endocytosis; D008954:Models, Biological; D008958:Models, Molecular; D009479:Neuropeptides / Q000737:chemistry / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D033921:Vesicular Transport Proteins
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; D009479:Neuropeptides; D033921:Vesicular Transport Proteins; C114154:epsin