title: XHRT-1, a hairy and Enhancer of split related gene with expression in floor plate and hypochord during early Xenopus embryogenesis.
abstract: We have isolated a Xenopus homologue of the mammalian hairy and Enhancer of split related gene HRT1. XHRT1 expression in late gastrula and early neurula embryos is restricted to two stripes of cells in the medial neural plate and in dorsal endodermal cells. At later stages, XHRT1 is expressed in the floor plate, in hypochord cells and in the somitogenic and anterior presomitic mesoderm. By tailbud stage, XHRT1 is also highly expressed in the dorsal hindbrain, telencephalon and eye vesicles, olfactory placodes, pronephros, branchial arches and tail fin. We also show that XHRT1 expression in medial neural cells is induced by Notch signaling and that there are differences in the way XHRT1 and other H/E(spl) genes are regulated.
authors.affiliation: IRIBHM, Université Libre de Bruxelles, Rue des Profs. Jeener et Brachet 12, 6041 Gosselies, Belgium.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pichon
authors.forename: Vincent
authors.initials: V
authors.lastname: Taelman
authors.forename: Sadia
authors.initials: S
authors.lastname: Kricha
authors.forename: Daniel
authors.initials: D
authors.lastname: Christophe
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Bellefroid
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005775:Gastrula / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D029867:Xenopus Proteins / Q000235:genetics* / Q000378:metabolism; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics*
chemical_list: C475489:HEY1 protein, Xenopus; D014157:Transcription Factors; D029867:Xenopus Proteins