Levels of tissue factor pathway inhibitor in lupus patients correlate with lupus activity and endothelial damage markers.
Tissue factor (TF) is a low molecular weight glycoprotein considered a major regulator of coagulation.1 Tissue factor pathway inhibitor (TFPI) appears to play a primary role in regulating TF-induced coagulation, as it is a potent inhibitor of activated factor VII/TF complexes. TFPI is expressed by the endothelium under normal physiologic conditions. The plasma concentration of TFPI is low, and only small amounts circulate in plasma as full-length molecule (free-TFPI).
Roldán
Vanessa
V
Marco
Pascual
P
Fernández
Cristina
C
Pascual
Eliseo
E
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008177:Lupus Vulgaris / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D015415:Biomarkers; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor