Role of genetic polymorphisms in tumour angiogenesis.
Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed.
Balasubramanian
S P
SP
Academic Unit of Surgical Oncology, University of Sheffield, Sheffield S10 2JF, UK.
Brown
N J
NJ
Reed
M W R
MW
D000818:Animals; D016207:Cytokines / Q000235:genetics; D016228:Endothelial Growth Factors / Q000235:genetics; D017228:Hepatocyte Growth Factor / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008222:Lymphokines / Q000235:genetics; D020782:Matrix Metalloproteinases / Q000235:genetics; D009369:Neoplasms / Q000098:blood supply* / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics*; D011110:Polymorphism, Genetic; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016207:Cytokines; D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D017468:Receptors, Fibroblast Growth Factor; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D017228:Hepatocyte Growth Factor; D020782:Matrix Metalloproteinases