Significance and expression of vascular endothelial growth factor and E-cadherin in non-small cell lung Carcinomas.
OBJECTIVE
To study the expression of vascular endothelial growth factor (VEGF) and E-cadherin (E-cd) in non-small cell lung carcinomas (NSCLC) and explore the mechanism of invasion and metastasis of tumor cell.


METHODS
The expression of VEGF and E-cd was analyzed in surgical specimens (43 cases of NSCLC) by SP immunohistochemical method.


RESULTS
The positive rates of VEGF in the case of good-differentiation and poor-middle-differentiation were 60.0% and 86.9% respectively, and those of E-cd were 65.0% and 34.9%. The expression of VEGF and E-cd in the case of metastasis was significantly different from that in the case without metastasis.


CONCLUSIONS
The expression of VEGF and E-cd is correlated well with invasion and metastasis of NSCLC.
Mei
Tonghua
T
Department of Lung, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China.
Zhang
Liping
L
Ma
Ying
Y
D015820:Cadherins; D002289:Carcinoma, Non-Small-Cell Lung; D006801:Humans; D008175:Lung Neoplasms; D008207:Lymphatic Metastasis; D011379:Prognosis; D055752:Small Cell Lung Carcinoma; D042461:Vascular Endothelial Growth Factor A
D015820:Cadherins; D042461:Vascular Endothelial Growth Factor A