title: Acute pancreatitis coincident with valproate use: a critical review.
abstract: OBJECTIVE
  Acute pancreatitis has been associated with a number of medications, including valproate (VPA). Valproate-coincident pancreatitis is uncommon and is usually associated with other risk factors; however, the United States Food and Drug Administration has issued a box warning for risk of acute pancreatitis with VPA products. We reviewed cases of pancreatitis in VPA-treated patients from the clinical database of VPA/divalproex trials and compared the incidence of elevated amylase levels between VPA- and placebo-treated patients.
  
  
  METHODS
  Report rates of acute pancreatitis coincident with VPA use in 34 clinical trials were calculated. Incidence rates of amylase elevations above the normal range in three clinical placebo-controlled migraine trials were compared between VPA- and placebo-treated patients.
  
  
  RESULTS
  Among 3,007 VPA-treated patients in 34 clinical trials, two reports of pancreatitis were considered by investigators to be probably related to VPA. Both patients recovered. Similar rates of amylase elevations were observed in VPA- (5.9%) and placebo-treated (6.1%) patients in the three migraine headache trials.
  
  
  CONCLUSIONS
  VPA-coincident acute pancreatitis is uncommon and idiosyncratic. Checking amylase levels in the absence of other clinical signs and symptoms provides little value for predicting pancreatitis. Physicians should be guided by clinical symptoms of pancreatitis to identify cases.
authors.affiliation: Virginia Commonwealth University Health Systems/Medical College of Virginia Hospitals, Richmond, Virginia 23298, USA. jpellock@hsc.vcu.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Pellock
authors.forename: B J
authors.initials: BJ
authors.lastname: Wilder
authors.forename: Roger
authors.initials: R
authors.lastname: Deaton
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Sommerville
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000681:Amylases / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D018849:Controlled Clinical Trials as Topic; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010195:Pancreatitis / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid; D000681:Amylases