title: Citalopram treatment of paroxetine-intolerant depressed patients.
abstract: We assessed the tolerability and antidepressant response to citalopram in a group of patients who could not tolerate a recent trial of paroxetine therapy. Sixty-one outpatients with major depressive disorder and a confirmed history of intolerance to paroxetine (mean final dose: 26.7 mg/day) were switched after at least a 1 week washout to citalopram therapy (20 mg/day). During the 6-week, open label treatment protocol, citalopram could be titrated up to a maximum dose of 40 mg/day. Response was evaluated using the Clinical Global Impressions CGI scale, the 24-item Hamilton Rating Scale for Depression, and several other measures of symptoms and quality of life. Fifty-three patients (87%) completed 6 weeks of citalopram therapy (mean intent-to-treat dose: 23.9 mg/day). The specific side effects that were reported to be intolerable during the earlier paroxetine trial typically recurred only less than 30% of the time during citalopram therapy; only 6 patients (10%) dropped out because of adverse events. The intent-to-treat CGI response rate was 56% at study endpoint; 62% of the completers responded. Significant improvement from pretreatment was observed on various symptom measures after two weeks of citalopram therapy. Citalopram therapy was well tolerated, and more than one half of the patients who began treatment improved significantly. Although further work is necessary to assess the relative merits of this within-class switching strategy (as compared to other options), these data provide further evidence that the various selective serotonin reuptake inhibitors do not have interchangeable tolerability profiles.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213-2593, USA. thaseme@msx.upmc.edu
authors.forename: Michael E
authors.initials: ME
authors.lastname: Thase
authors.forename: James M
authors.initials: JM
authors.lastname: Ferguson
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Lydiard
authors.forename: Charles S
authors.initials: CS
authors.lastname: Wilcox
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000188:drug therapy; D015283:Citalopram / Q000008:administration & dosage / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000009:adverse effects*; D011446:Prospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D015283:Citalopram; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors