[Proinflammatory cytokines (IL-6, TNF-alpha) and cardiac troponin I (cTnI) in serum of young people with ventricular arrhythmias].
In the most cases the origin of ventricular arrhythmias is ischaemic, necrosis focus or presence of the connective tissue in cardiac muscle. The aim of the study was to evaluate troponin I (cTnI), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) vs in young subject with ventricular arrhythmias. Into the study group included young people without organic heart diseases, dyselectrolitemia, with normal ECG which has not elevated levels of C-reactive protein (55 persons). The control group consisted of 22 healthy persons. The values of cTnI were not increased. The TNF-alpha concentrations were elevated in persons with ventricular arrhythmias (92 +/- 232 pg/mL vs. 2 +/- 1 pg/mL, p < 0.001). The IL-6 concentrations were slightly elevated without statistical significance (1.5 +/- 4.5 pg/mL i 0.1 +/- 0.04 pg/mL, p = 0.06).


CONCLUSIONS
There was no evidence of myocardial injury in young people with ventricular arrhythmias (cTnI). We noted increase levels of proinflammatory cytokines. It might suggest that the background of ventricular arrhythmias is inflammation.
Kowalewski
Marek
M
II Klinika Chorób Dzieci AM w Białymstoku.
Urban
Mirosława
M
Mroczko
Barbara
B
Szmitkowski
Maciej
M
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017248:Enzyme Multiplied Immunoassay Technique; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D017180:Tachycardia, Ventricular / Q000097:blood*; D019210:Troponin I / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014693:Ventricular Fibrillation / Q000097:blood*
D015415:Biomarkers; D015850:Interleukin-6; D019210:Troponin I; D014409:Tumor Necrosis Factor-alpha