title: Effect of peripapillary chorioretinal atrophy on GDx parametersin patients with degenerative myopia.
abstract: OBJECTIVE
  To determine the effect of peripapillary chorioretinal atrophy in degenerative myopia on the retinal nerve fibre layer (RNFL) thickness measurements performed by scanning laser polarimetry.
  
  
  METHODS
  Polarimetric RNFL analysis was done in 41 degenerative myopic eyes of 25 patients with spherical refractive errors between -7.50 and -22.00 D (mean -12.50 D;SD 3.5). Analysis was also performed on 46 eyes of 24 age-matched healthy subjects with spherical refractive errors between -1.00 and +1.00 D (mean -0.25 D; SD 0.50) with GDx Nerve Fiber Analyzer (Version 1.0.12). All of the myopic patients had clinically evident peripapillary chorioretinal atrophy in their fundus examination.
  
  
  RESULTS
  In myopic patients most of the GDx parameters were statistically different from the control group (P < 0.05). Although average thickness, ellipse average, number, inferior maximum and inferior average were found to be higher than the healthy subjects,the modulation parameters and the ratio-based parameters were significantly decreased in degenerative myopic patients (P < 0.05). The TSNIT (temporal, superior, nasal, inferior, temporal) graph showed irregular high spikes with loss of the regular double hump pattern, especially in quadrants with large chorioretinal atrophy and visible sclera.
  
  
  CONCLUSIONS
  Peripapillary chorioretinal atrophy increased retardation values, which might be explained by the high reflectivity of the bare sclera in these areas.
authors.affiliation: Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Bozkurt
authors.forename: Murat
authors.initials: M
authors.lastname: Irkeç
authors.forename: Sansal
authors.initials: S
authors.lastname: Gedik
authors.forename: Mehmet
authors.initials: M
authors.lastname: Orhan
authors.forename: Ugur
authors.initials: U
authors.lastname: Erdener
authors.forename: Sinan
authors.initials: S
authors.lastname: Tatlipinar
authors.forename: Ergun
authors.initials: E
authors.lastname: Karaagaoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001718:Birefringence; D002648:Child; D015862:Choroid Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000473:pathology; D009412:Nerve Fibers / Q000473:pathology*; D009896:Optic Atrophy / Q000209:etiology* / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*