New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae.
Wood from three different plants of the Celastraceae growing in their natural habitats in Brazil (Maytenus aquifolia Mart.) and South Africa [Putterlickia retrospinosa van Wyk and Mostert, P. verrucosa (E. Meyer ex Sonder) Szyszyl.] was established as a source of endophytic bacteria using a medium selective for actinomycetes. Two isolates were identified as Streptomyces setonii and S. sampsonii whereas two others were not assignable to any of the known Streptomyces species. They were preliminarily named Streptomyces Q21 and Streptomyces MaB-QuH-8. The latter strain produces a new chloropyrrol and chlorinated anthracyclinone. The chloropyrrol showed high activity against a series of multiresistent bacteria and mycobacteria.
Pullen
Christian
C
Institut für Pharmazeutische Biologie der Universität Bonn, Nussallee 6, 53115 Bonn, Germany.
Schmitz
Petra
P
Meurer
Kristina
K
Bamberg
Daniel D v
DD
Lohmann
Stephanie
S
De Castro França
Suzelei
S
Groth
Ingrid
I
Schlegel
Brigitte
B
Möllmann
Ute
U
Gollmick
Friedrich
F
Gräfe
Udo
U
Leistner
Eckhard
E
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029753:Celastraceae / Q000378:metabolism / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D029755:Maytenus / Q000378:metabolism / Q000382:microbiology; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D001685:Biological Factors; D009285:Naphthoquinones; D011758:Pyrroles; D012118:Resorcinols; C472377:celastramycin A; C472378:celastramycin B