Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected deer, elk, sheep, and cattle.
Analysis of abnormal prion protein glycoform patterns from chronic wasting disease (CWD)-affected deer and elk, scrapie-affected sheep and cattle, and cattle with bovine spongiform encephalopathy failed to identify patterns capable of reliably distinguishing these transmissible spongiform encephalopathy diseases. However, PrP-res patterns sometimes differed among individual animals, suggesting infection by different or multiple CWD strains in some species.
Race
Richard E
RE
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
Raines
Anne
A
Baron
Thierry G M
TG
Miller
Michael W
MW
Jenny
Allen
A
Williams
Elizabeth S
ES
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D003670:Deer; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics / Q000378:metabolism*; D006031:Glycosylation; D015151:Immunoblotting; D008969:Molecular Sequence Data; D018620:PrPSc Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification; D012608:Scrapie / Q000235:genetics / Q000378:metabolism*; D012756:Sheep; D013045:Species Specificity; D034081:Wasting Disease, Chronic / Q000235:genetics / Q000378:metabolism*
D018620:PrPSc Proteins