title: Surveillance in Barrett's oesophagus: a critical reappraisal.
abstract: BACKGROUND
  Current recommendations are for endoscopic surveillance of patients with Barrett's oesophagus to detect dysplasia and to diagnose carcinoma at an early and possibly treatable stage. However, observations suggest that these current practice guidelines are thwarted by many factors often not taken into account. These observations stem from general surveillance aspects as well from specific data on Barrett's oesophagus. This review therefore aims at discussing data on the current surveillance strategy in conjunction with general surveillance aspects relevant for their interpretation.
  
  
  METHODS
  Literature survey of published articles.
  
  
  RESULTS
  A critical reappraisal of the literature shows that the current surveillance strategy is hampered by multiple problems with the marker dysplasia, cost-ineffectiveness, an overrated cancer risk and an astonishing lack of prospective, randomized data showing a clear benefit in terms of a greater life expectancy. Moreover, the decisive study is unlikely ever to be performed because of the large number of patients needed and the required length of follow-up. As a result, protocols are being carried out that have never been critically tested prior to large-scale clinical implementation.
  
  
  CONCLUSIONS
  Although these findings should not lead to therapeutic nihilism, the data raise the issue of whether or not surveillance protocols should be restricted to specialized referral centres with particular research efforts aimed at improving existing and developing new techniques that lack most of the described pitfalls and problems. Since it is foreseen that matters will not change rapidly in the (near) future, the clinician has no other choice than to rely on individually tailored arguments to survey taking into account for example family history, age and anxiety about potential long-term effects.
authors.affiliation: Dept. of Gastroenterology,Vrije Universiteit Medical Center, Amsterdam, The Netherlands. me.craanen@vumc.nl
authors.forename: M E
authors.initials: ME
authors.lastname: Craanen
authors.forename: P
authors.initials: P
authors.lastname: Blok
authors.forename: G A
authors.initials: GA
authors.lastname: Meijer
authors.forename: S G M
authors.initials: SG
authors.lastname: Meuwissen
mesh_terms: D001471:Barrett Esophagus / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D011159:Population Surveillance; D012680:Sensitivity and Specificity; D013997:Time Factors