title: Acute lymphoblastic leukemia relapse in the breast diagnosed with gray-scale and color Doppler sonography.
abstract: Extramedullary relapses of acute lymphoblastic leukemia (ALL) in children and young adults are rare and in most cases are localized in the central nervous system, testes, or both. We describe a rare case of extramedullary relapse of ALL in the breast of a 17-year-old girl. The patient, who had been diagnosed with ALL 1 year before and had been in complete remission for 5 months, was admitted to the hospital for investigation of a mass in her left breast. On clinical examination, she had a large, palpable, nontender mass in her left breast. Mammography revealed a very dense mass. On gray-scale and power Doppler sonography, the appearance of the mass was consistent with malignancy. Histopathologic examination of a surgical biopsy specimen permitted accurate diagnosis of ALL.
authors.affiliation: Department of Radiology, University Hospital of Patras, 26500 Rion, Patras, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Likaki-Karatza
authors.forename: Filitsa A
authors.initials: FA
authors.lastname: Mpadra
authors.forename: Michalis V
authors.initials: MV
authors.lastname: Karamouzis
authors.forename: Panagiota
authors.initials: P
authors.lastname: Ravazoula
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Koukouras
authors.forename: Sofia
authors.initials: S
authors.lastname: Margariti
authors.forename: Ioannis
authors.initials: I
authors.lastname: Dimopoulos
mesh_terms: D000293:Adolescent; D001940:Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D018615:Ultrasonography, Doppler, Color