title: Shoshin beriberi with vasospastic angina pectoris possible mechanism of mid-ventricular obstruction: possible mechanism of mid-ventricular obstruction.
abstract: A 73-year-old heavy drinker was admitted to hospital in a state of shock. He had been suffering from frequent angina at rest, causing him to drink more heavily in an effort to overcome his anginal chest pain. He had been drinking hard each day and had not eaten for 4 weeks. His hemodynamic state on admission showed high-output heart failure. Echocardiography revealed hyperkinesis of the left ventricle and mid-ventricular obstruction with peak intraventricular gradients of 30 mmHg. Although no improvement was seen despite administering the maximal dose in catecholamine therapy, his condition improved rapidly after vitamin B(1) was administered. Cardiac catheterization revealed mid-ventricular obstruction with an apical aneurysm. Coronary artery spasm was induced by injecting acetylcholine in the distal site of the left anterior descending artery, which perfused the area of the apical aneurysm. In the present case, both left ventricular hyperkinesis caused by shoshin beriberi and apical myocardial infarction caused by frequent coronary spasms produced mid-ventricular obstruction with an apical aneurysm.
authors.affiliation: First Department of Internal Medicine, Niigata University School of Medicine, Japan. masahiro@med.niigata-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Kaoru
authors.initials: K
authors.lastname: Suzuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Kumakura
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000368:Aged; D000437:Alcoholism; D000787:Angina Pectoris / Q000150:complications* / Q000175:diagnosis; D001602:Beriberi / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002395:Catecholamines / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000150:complications* / Q000175:diagnosis; D004452:Echocardiography; D006322:Heart Aneurysm / Q000175:diagnosis / Q000209:etiology; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D008297:Male; D013831:Thiamine / Q000627:therapeutic use; D014694:Ventricular Outflow Obstruction / Q000175:diagnosis / Q000209:etiology*
chemical_list: D002395:Catecholamines; D013831:Thiamine