title: Marked increase of CD5 + B cells in hyperthyroid Graves' disease.
abstract: We examined the proportions of B lymphocytes bearing CD5 cell surface antigen (CD5+ B cells), which are capable of making autoantibodies, in peripheral blood from patients with various thyroid diseases. The level of CD5+ B cells was markedly increased (>9.0%) above the normal range (0.5-7.7%) in untreated, hyperthyroid patients with Graves' disease, although about 10% of the patients had no detectable serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb). However, the levels of CD5+ B cells were normal in untreated patients with destructive thyrotoxicosis due to aggravation of Hashimoto's thyroiditis or subacute thyroiditis. In patients with stimulated hyperthyroid Graves' disease the levels of CD5+ B cells were correlated with those of thyroid hormones and TRAb, all significantly increased. However, once hyperthyroidism was controlled by anti-thyroid drugs, CD5+ B cells were decreased, followed in turn by reduction of TRAb. We conclude that the proportion of CD5+ B cells is useful as a therapeutic index and for diagnosis of Graves' disease and its differentiation from destruction-induced thyrotoxicosis.
authors.affiliation: Department of Laboratory Medicine, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwatani
authors.forename: N
authors.initials: N
authors.lastname: Amino
authors.forename: T
authors.initials: T
authors.lastname: Kaneda
authors.forename: K
authors.initials: K
authors.lastname: Ichihara
authors.forename: H
authors.initials: H
authors.lastname: Tamaki
authors.forename: J
authors.initials: J
authors.lastname: Tachi
authors.forename: F
authors.initials: F
authors.lastname: Matsuzuka
authors.forename: S
authors.initials: S
authors.lastname: Fukata
authors.forename: K
authors.initials: K
authors.lastname: Kuma
authors.forename: K
authors.initials: K
authors.lastname: Miyai
mesh_terms: D000328:Adult; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D018956:CD5 Antigens / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006111:Graves Disease / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D018956:CD5 Antigens