Correction of L-NAME-induced disturbances in DNA synthesis and free radical oxidation in respiratory organs of newborn albino rats with dalargin.
Intraperitoneal injections of L-NAME (5 injections, 9.3 x 10(-5) mol/kg each) to albino rats from the 2nd to 6th day of life inhibited DNA synthesis in epithelial cells, stimulated this process in bronchial smooth muscle cells, and intensified free radical oxidation in the lungs. Dalargin administered in a dose of 1.4 x 10(-7) mol/kg 30 min after treatment with NG-nitro-L-arginine methyl ester abolished its effect on epithelial cells and attenuated changes in smooth muscle cells. Correcting activity of dalargin is associated with its antiradical and antioxidant properties.
Lebed'ko
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Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern Research Center for Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences. lebedko@mail.ru
Timoshin
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D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D009130:Muscle, Smooth / Q000166:cytology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D004791:Enzyme Inhibitors; D005609:Free Radicals; D016308:Enkephalin, Leucine-2-Alanine; D004247:DNA; D010100:Oxygen; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D019331:NG-Nitroarginine Methyl Ester