title: Morphological changes of the arterial systems in the kidney under prolonged continuous flow left heart bypass.
abstract: We investigated morphological changes of the arterial systems in the kidneys under prolonged continuous flow left heart bypass. Twelve goats were subjected to 2 weeks of pulsatile left heart bypass followed by 4 weeks of continuous flow left heart bypass (group CF). After autopsy, the kidneys underwent pathological evaluation. Six normal healthy goats were used as controls. The media of the afferent arterioles of group CF were frequently thickened by an increase in the number of the mature smooth muscle cells (SMCs). The juxtaglomerular areas (JGA) were expanded because of an increase in the number and size of SMCs and/or SMC-like cells. Furthermore, the percentage of anti-proliferating cell nuclear antigen antibody-positive cells in the JGA of group CF (9.9 +/- 1.9%) was significantly higher (p = 0.025) than that of the control group (4.6 +/- 3.4%), indicating active proliferation in group CF. We concluded that prolonged continuous flow left heart bypass causes proliferation of SMCs and/or SMC-like cells in the afferent arterioles and their perivascular tissue.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Research Institute, Osaka, Japan. hohnishi@ri.ncvc.go.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Itoh
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nishinaka
authors.forename: Eisuke
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Toshihide
authors.initials: T
authors.lastname: Fukuda
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Oshikawa
authors.forename: Kyoko
authors.initials: K
authors.lastname: Shioya
authors.forename: Tomonori
authors.initials: T
authors.lastname: Tsukiya
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takewa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Homma
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Uesho
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Hisateru
authors.initials: H
authors.lastname: Takano
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Taenaka
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology* / Q000628:therapy*; D004195:Disease Models, Animal; D006041:Goats; D018611:Heart Bypass, Left; D006439:Hemodynamics / Q000502:physiology; D007606:Juxtaglomerular Apparatus / Q000473:pathology / Q000503:physiopathology; D011673:Pulsatile Flow / Q000502:physiology; D012077:Renal Artery / Q000473:pathology* / Q000503:physiopathology; D012079:Renal Circulation / Q000502:physiology; D013997:Time Factors; D017540:Tunica Media / Q000473:pathology / Q000503:physiopathology