title: Carcinogenicity of saccharin in laboratory animals and humans: letter to Dr. Harry Conacher of Health Canada.
abstract: We appreciate this opportunity to provide input to the Health Protection Branch's (HPB's) review of the artificial sweetener saccharin. Concerns with regard to the safety of saccharin are of great public health significance and of great interest to the public because saccharin is consumed by tens of millions of people, including children and fetuses. Any evidence of carcinogenesis--and there is ample such evidence--of such a widely used chemical should spur health officials to minimize human exposure to it. It is worth noting that on October 31, 1997, the Board of Scientific Counselors of the National Toxicology Program, a unit of the National Institute of Environmental Health Sciences (NIEHS), voted not to delist saccharin from its Report on Carcinogens.
authors.affiliation: Canadian Association of Physicians for the Environment, Salmon Arm, BC.
authors.forename: Warren
authors.initials: W
authors.lastname: Bell
authors.forename: Richard
authors.initials: R
authors.lastname: Clapp
authors.forename: Devra
authors.initials: D
authors.lastname: Davis
authors.forename: Samuel
authors.initials: S
authors.lastname: Epstein
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Farber
authors.forename: Donald A
authors.initials: DA
authors.lastname: Fox
authors.forename: Bruce
authors.initials: B
authors.lastname: Holub
authors.forename: Michael F
authors.initials: MF
authors.lastname: Jacobson
authors.forename: William
authors.initials: W
authors.lastname: Lijinsky
authors.forename: Erik
authors.initials: E
authors.lastname: Millstone
authors.forename: Melvin D
authors.initials: MD
authors.lastname: Reuber
authors.forename: David
authors.initials: D
authors.lastname: Suzuki
authors.forename: Norman J
authors.initials: NJ
authors.lastname: Temple
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D003043:Cocarcinogenesis; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009153:Mutagens; D051381:Rats; D018570:Risk Assessment; D012439:Saccharin / Q000009:adverse effects / Q000633:toxicity*; D013549:Sweetening Agents / Q000009:adverse effects / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
chemical_list: D009153:Mutagens; D013549:Sweetening Agents; D012439:Saccharin