A facile ligation approach to prepare three-helix bundles of HIV fusion-state protein mimetics.
We have designed a facile ligation approach to prepare three-helix bundles mimicking the HIV membrane fusion-state proteins that may be useful as inhibitors and vaccine candidates for blocking HIV infection. [reaction: see text]
Tam
James P
JP
Department of Microbiology and Immunology, Vanderbilt University, A 5119 MCN, Nashville, TN 37323, USA. james.tam@vanderbilt.edu
Yu
Qitao
Q
D000595:Amino Acid Sequence; D006678:HIV / Q000737:chemistry* / Q000502:physiology; D015658:HIV Infections / Q000503:physiopathology; D006801:Humans; D008561:Membrane Fusion; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D014764:Viral Proteins / Q000138:chemical synthesis* / Q000737:chemistry*
D014764:Viral Proteins