title: Invasive squamous cell carcinoma of the vagina during pregnancy.
abstract: BACKGROUND
  Squamous cell carcinoma of the vagina in pregnancy is rare.
  
  
  METHODS
  A 28-year-old primigravida with antepartum bleeding at 20 weeks' gestation was diagnosed with squamous cell carcinoma after biopsy of a vaginal mass. The histology revealed an invasive grade 3 squamous cell carcinoma of large-cell, nonkeratinizing type. The patient declined pregnancy termination and immediate radiation treatment. She continued to have episodes of vaginal bleeding and was admitted at 30 weeks' gestation. A decision was made in consultation with the neonatal unit to deliver her at 32 weeks' gestation. After corticosteroid treatment, she was delivered by cesarean delivery. Positive pelvic lymph nodes were noted at surgery. Postoperatively, she received external beam radiation and brachytherapy and concurrent cisplatin chemotherapy. She is disease free 3 years from her original diagnosis.
  
  
  CONCLUSIONS
  This case emphasizes the importance of a thorough pelvic examination to assess the vaginal walls and cervix at the first prenatal visit and with any antepartum bleeding episode.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada. helensteed@shaw.ca
authors.forename: H L
authors.initials: HL
authors.lastname: Steed
authors.forename: R G
authors.initials: RG
authors.lastname: Pearcey
authors.forename: V
authors.initials: V
authors.lastname: Capstick
authors.forename: L H
authors.initials: LH
authors.lastname: Honore
mesh_terms: D000328:Adult; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D011879:Radiotherapy Dosage; D014625:Vaginal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*
chemical_list: D002945:Cisplatin