[Psychiatric complications of corticoid therapy in the elderly over 65 years of age treated for Horton disease].
OBJECTIVE
To analyse steroid psychiatric related complications in aged (> 65 years old) with temporal arteritis (TA).


METHODS
Retrospective cohort study.


METHODS
In a cohort of 126 elderly patients with a diagnosis of TA and followed with a mean period of 64 months, clinical and biological presentations, outcome and corticoid adverse effects were recorded throughout the follow-up period.


RESULTS
Twenty patients (16%), (mean age: 73 +/- 7.9 years, male n = 6) exhibited corticosteroid related psychiatric complications. Symptoms appear to be dose dependent and generally begin during the first month of treatment. Psychiatric disorders were as follow: mood disturbances (n = 8), depression (n = 6), mania (n = 3), anxiety neurosis (n = 2) and dementia (n = 1). Three patients were hospitalized in psychiatric units and 2 in nursing home. Psychiatric adverse affects appears to be more frequent with prednisone than prednisolone (P < 0.05).
Fauchais
A L
AL
Service de médecine interne A, hôpital Claude-Huriez, CHRU, 59037 Lille, France. al.fauchais@caramail.com
Boivin
V
V
Hachulla
E
E
Michon-Pasturel
U
U
Lambert
M
M
Queyrel
V
V
Hebbar
M
M
Hatron
P Y
PY
Devulder
B
B
D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000139:chemically induced; D001714:Bipolar Disorder / Q000139:chemically induced; D003027:Cluster Headache / Q000188:drug therapy*; D015331:Cohort Studies; D003863:Depression / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000009:adverse effects; D011241:Prednisone / Q000009:adverse effects; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies
D000893:Anti-Inflammatory Agents; D011239:Prednisolone; D011241:Prednisone