Acute isolated bulbar palsy with anti-GT1a IgG antibody subsequent to Campylobacter jejuni enteritis.
We describe a patient with acute isolated bulbar palsy following enteritis. A 29-year-old man developed dysphagia and nasal voice without limb weakness, ataxia, or areflexia. High titres of serum anti-GT1a and anti-Campylobacter jejuni IgG antibodies were detected. He was treated with plasmapheresis, resulting in rapid clinical improvement. This case suggests that an acute isolated bulbar palsy may be caused by a pathology relating to Guillain-Barré syndrome (GBS), in which anti-GT1a IgG antibody may have a role.
Onodera
Masakazu
M
Department of Neurology, Chiba Rosai Hospital, Chiba, Japan.
Mori
Masahiro
M
Koga
Michiaki
M
Kamitsukasa
Ikuo
I
Fukutake
Toshio
T
Hattori
Takamichi
T
Yuki
Nobuhiro
N
Kuwabara
Satoshi
S
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D010244:Bulbar Palsy, Progressive / Q000097:blood / Q000150:complications / Q000276:immunology*; D002169:Campylobacter Infections / Q000150:complications / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology*; D004751:Enteritis / Q000150:complications / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000150:complications; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D008297:Male; D010956:Plasmapheresis
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; C016481:trisialoganglioside GT1