New biology of aldosterone, and experimental studies on the selective aldosterone blocker eplerenone.
Funder
John W
JW
Centre for Neurosciences, University of Melbourne and Prince Henry's Institute of Medical Research, Monash Medical Centre, Victoria, Australia. susan.smith@med.monash.edu.au
D000450:Aldosterone / Q000009:adverse effects / Q000502:physiology*; D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced; D002986:Clinical Trials as Topic; D003900:Desoxycorticosterone / Q000009:adverse effects; D000077545:Eplerenone; D005355:Fibrosis / Q000139:chemically induced; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use*; D009206:Myocardium / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D018161:Receptors, Mineralocorticoid / Q000378:metabolism; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000451:Mineralocorticoid Receptor Antagonists; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone; D003900:Desoxycorticosterone; D000450:Aldosterone; D000077545:Eplerenone