title: Significance and expression of vascular endothelial growth factor and E-cadherin in non-small cell lung Carcinomas.
abstract: OBJECTIVE
  To study the expression of vascular endothelial growth factor (VEGF) and E-cadherin (E-cd) in non-small cell lung carcinomas (NSCLC) and explore the mechanism of invasion and metastasis of tumor cell.
  
  
  METHODS
  The expression of VEGF and E-cd was analyzed in surgical specimens (43 cases of NSCLC) by SP immunohistochemical method.
  
  
  RESULTS
  The positive rates of VEGF in the case of good-differentiation and poor-middle-differentiation were 60.0% and 86.9% respectively, and those of E-cd were 65.0% and 34.9%. The expression of VEGF and E-cd in the case of metastasis was significantly different from that in the case without metastasis.
  
  
  CONCLUSIONS
  The expression of VEGF and E-cd is correlated well with invasion and metastasis of NSCLC.
authors.affiliation: Department of Lung, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China.
authors.forename: Tonghua
authors.initials: T
authors.lastname: Mei
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
mesh_terms: D015820:Cadherins; D002289:Carcinoma, Non-Small-Cell Lung; D006801:Humans; D008175:Lung Neoplasms; D008207:Lymphatic Metastasis; D011379:Prognosis; D055752:Small Cell Lung Carcinoma; D042461:Vascular Endothelial Growth Factor A
chemical_list: D015820:Cadherins; D042461:Vascular Endothelial Growth Factor A