Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain.
We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.
Wang
Cong
C
Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.
Shimizu-Okabe
Chigusa
C
Watanabe
Kazuo
K
Okabe
Akihito
A
Matsuzaki
Hideo
H
Ogawa
Tsuguhiro
T
Mori
Norio
N
Fukuda
Atsuo
A
Sato
Kohji
K
D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology*; D002712:Chlorides / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D028021:Sodium-Potassium-Chloride Symporters / Q000096:biosynthesis*; D064506:Solute Carrier Family 12, Member 2; D027981:Symporters / Q000096:biosynthesis*; D000096922:K Cl- Cotransporters
D002712:Chlorides; D015347:RNA Probes; D012333:RNA, Messenger; D028021:Sodium-Potassium-Chloride Symporters; D064506:Solute Carrier Family 12, Member 2; D027981:Symporters; D000096922:K Cl- Cotransporters; C578879:Slc12a2 protein, rat