Biochemical and metabolic peculiarities of some parasites availing as targets for therapy.
Biochemical and metabolic peculiarities of some parasites involved in their interactions with their hosts are reviewed according to (1) carbohydrate metabolism comprising glycolysis, Pasteur effect, CO2 fixation and electron transport system; (2) amino acid and protein metabolism ; (3) purine and pyrimidine nucleotides metabolism. These peculiarities are becoming targets for treatment without affecting the host.
Frayha
G J
GJ
Faculty of Pharmaceutical and Biological Sciences, University of René Descartes, Paris, France. fgfreiha@inco.com.lb
Gobert
J G
JG
Savel
J
J
D000596:Amino Acids / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D000977:Antiparasitic Agents / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D001692:Biological Transport; D050260:Carbohydrate Metabolism; D004734:Energy Metabolism; D006019:Glycolysis; D006790:Host-Parasite Interactions; D006801:Humans; D009534:Niclosamide / Q000627:therapeutic use; D009593:Nitroimidazoles / Q000627:therapeutic use; D010271:Parasites / Q000187:drug effects* / Q000378:metabolism*; D010272:Parasitic Diseases / Q000188:drug therapy* / Q000378:metabolism*; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D011685:Purine Nucleotides / Q000378:metabolism; D011742:Pyrimidine Nucleotides / Q000378:metabolism
D000596:Amino Acids; D000962:Antimalarials; D000977:Antiparasitic Agents; D001562:Benzimidazoles; D009593:Nitroimidazoles; D011506:Proteins; D011685:Purine Nucleotides; D011742:Pyrimidine Nucleotides; D009534:Niclosamide; D000967:Antimony Sodium Gluconate