Neuroprotective effect of hypoxic preconditioning: phenomenon and mechanisms.
We developed a new model of hypoxic preconditioning improving tolerance of complete global cerebral ischemia. The role of adenosine receptors in the realization of this effect and in the mechanisms of hypoxic tolerance is demonstrated. Preconditioning decreases of body temperature, which correlates with the neuroprotective effect, but this effect does not directly result from hypothermia.
Kulinskii
V I
VI
Department of Biochemistry, Department of Pharmacology, Irkutsk State Medical University. kulinsky@pp.irkutsk.ru
Minakina
L N
LN
Gavrilina
T V
TV
D000818:Animals; D001831:Body Temperature; D005260:Female; D000860:Hypoxia; D019194:Ischemic Preconditioning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D012119:Respiration; D013223:Statistics as Topic; D015996:Survival Rate; D013806:Theophylline / Q000378:metabolism; D014665:Vasodilator Agents / Q000378:metabolism
D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D013806:Theophylline