title: There is no clear association between low serum ferritin and chronic diffuse telogen hair loss.
abstract: BACKGROUND
  Low iron stores are considered a possible cause of chronic diffuse telogen hair loss in women. Estimation of serum ferritin is recommended as part of the initial assessment when women present with chronic diffuse telogen hair loss, and iron supplementation therapy is commonly recommended for those found to have low iron stores.
  
  
  OBJECTIVE
  To evaluate the relationship between low serum ferritin (</=20 micro g L-1) and chronic diffuse telogen hair loss in women.
  
  
  METHODS
  Between 1997 and 1999, 194 consecutive women who presented to a specialist hair clinic were assessed for diffuse telogen hair loss of greater than 6 months duration. All underwent biochemical investigations that included serum ferritin and had two 4-mm punch biopsies taken from the vertex of the scalp. One biopsy was sectioned horizontally and the other vertically.
  
  
  RESULTS
  Twelve women were found to have a serum ferritin of 20 micro g L-1 or less (6.2%). Androgenetic alopecia was found on scalp biopsy in seven of these 12 women, while the other five women had normal histology. The five women with low iron stores and normal histology were treated with iron supplementation alone. This was continued until the serum ferritin was > 20 micro g L-1. Cessation or reversal of hair loss was not seen in any of these women.
  
  
  CONCLUSIONS
  No direct relationship between low serum ferritin and hair loss can be established. The usefulness of serum ferritin in the routine investigation of women with chronic diffuse telogen hair loss is unclear, as is the role of iron supplementation therapy in the management of hair loss.
authors.affiliation: University of Melbourne Department of Dermatology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia. Sinclair@svhm.org.au
authors.forename: R
authors.initials: R
authors.lastname: Sinclair
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000505:Alopecia / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002648:Child; D002908:Chronic Disease; D005260:Female; D005293:Ferritins / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D005293:Ferritins; D007501:Iron