Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells.
Replication of UV-induced photoproducts requires the activity of specific DNA polymerases. The DNA polymerase eta, the absence of which gives rise to the cancer-prone xeroderma pigmentosum variant syndrome, is one of these translesion DNA polymerases. Other error-prone DNA polymerases are present in human cells and may contribute to the UV-induced mutation spectrum.
Stary
Anne
A
Laboratory of Genetic Instability and Cancer, UPR 2169 CNRS, Villejuif, France.
Sarasin
Alain
A
D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D006801:Humans; D009154:Mutation; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014983:Xeroderma Pigmentosum / Q000201:enzymology / Q000235:genetics; D000099270:Y-Family DNA Polymerases
D004259:DNA-Directed DNA Polymerase; C112338:Rad30 protein; D000099270:Y-Family DNA Polymerases