[Effect of attenuation correction and scatter compensation on the 99mTc-MIBI myocardial perfusion spect in patients without coronary artery disease].
OBJECTIVE
Attenuation correction (AC) and scatter compensation (SC) techniques are recent developments of myocardial perfusion SPECT. Our aim was to evaluate the effect of AC + SC on the myocardial distribution of 99mTc-MIBI in a population without coronary artery disease.


METHODS
A multiarray of Gd-153 linear sources was used for simultaneous transmission/emission 99mTc-MIBI myocardial perfusion SPECT in 27 patients without coronary artery disease. A visual analysis and polar map quantification was performed. Changes between non-corrected (NC) and corrected (AC + SC) studies were compared.


RESULTS
AC + SC produced an increase in liver activity and better visualization of the right ventricle. Intestinal activity increased in six patients. Myocardial homogeneity was increased by AC + SC. No differences by gender were observed after AC + SC. In females AC + SC led to a decrease of uptake in the anterior wall, apex and apical segments of the lateral wall and septum, and an increase in the inferior wall. In males AC + SC caused an increase of uptake in the inferior wall and in the basal segments of septum and a decrease of uptake in apex and apical segments of anterior and lateral walls. AC + SC generated false defects in the anterior wall of five patients.


CONCLUSIONS
Our results show the usefulness of AC + SC for compensating the interferences produced by attenuation on the myocardial distribution of 99mTc-MIBI. Because AC + SC may introduce false defects, it must not be applied to normal perfused myocardium.
Banzo
I
I
Servicio de Medicina Nuclear. Hospital Universitario Marqués de Valdecilla. Unidad de Cantabria. Santander. Spain.
Carril
J M
JM
Jiménez-Bonilla
J
J
Pena
F J
FJ
Allende
R H
RH
Quirce
R
R
Guede
C
C
D000328:Adult; D016477:Artifacts; D001940:Breast / Q000000981:diagnostic imaging; D005189:False Positive Reactions; D005260:Female; D005769:Gastrointestinal Motility; D006321:Heart / Q000000981:diagnostic imaging*; D006346:Heart Septum / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia; D015588:Observer Variation; D010280:Parathyroid Glands / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D012016:Reference Values; D012542:Scattering, Radiation; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi