Antioxidant system in Down syndrome: a possible role in cataractogenesis.
Recent studies show a relationship between oxidants, antioxidants, and degenerative disease of aging like cataract formation. Focal lens cortical changes and cortical liquification have been reported in patients with Down syndrome (DS) over 14 years. There is evidence supporting the hypothesis that trisomy 21 patients have an increase in free radical reactions. These changes in antioxidant system may play a role in cataractogenesis in Down syndrome. We screened serum samples from 12 patients with DS and cataract: and 12 healthy age and sex-matched persons. We evaluated the antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST) and reduced glutathione (GSH) in erythrocytes. SOD and GSHPx levels of patients with DS were significantly higher than the control group. No significant changes were observed in GST and GSH levels between the DS and control groups. These findings suggest impairment in antioxidant system, which may be a possible mechanism for early cataract formation in DS.
Cengiz
M
M
I.U. Cerrahpasa Tip Fakültesi, Genetik ve Teratoloji Uygulama ve Arastirma Merkezi, Cerrahpasa, Istanbul, Turkey. cengizms@ttnet.net.tr
Seven
M
M
Suyugül
N
N
D000375:Aging / Q000378:metabolism / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002386:Cataract / Q000201:enzymology / Q000209:etiology*; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione