[Immunopathogenesis of psoriasis and its current therapy ].
Psoriasis is a partly inflammatory hyperproliferative skin disease. Its origin has not been clarified yet, but numerous immunologic, bioregulatory, and biochemical changes accompanying this disease are known. Many cell types and a number of immunity system factors forming a perfectly interlinked network are involved in the immunity processes in the psoriasis-affected skin. This network is a common place where antipsoriatics operate. There is no therapeutic means known which guarantees permanent elimination of psoriasis symptoms. External as well as internal therapeutic methods having effect on the pathogenetic processes at various levels are combined. UV radiation treatment (SUP), sometimes combined with psoralens (PUVA), tar, and dithranol are some of the classical methods of psoriasis treatment. Topical medicamentous treatment with corticoids, vitamin D derivatives, salicylic acid, urea, and tar plays an important part here.
Svozil
M
M
Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. svozil@faf.cuni.cz
D006801:Humans; D011565:Psoriasis / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy