title: The epidemiology of diabetic limb sepsis: an African perspective.
abstract: We review the epidemiology of foot and hand sepsis in adult diabetes patients in Africa. Limb sepsis in these patients is associated with significant morbidity and mortality. The pathogenesis of diabetic foot infections in these patient populations appears to be similar to that for patients in industrialized countries -ulcers and underlying peripheral neuropathy being the most important risk factors. Prevention of peripheral neuropathy through aggressive glycaemic control may be the most important primary control measure for foot infections. The tropical diabetic hand syndrome (TDHS) is being increasingly seen in diabetes patients in certain parts of Africa. The syndrome is acute, usually follows minor trauma to the hand, and is associated with a progressive synergistic form of gangrene. The major risk factors for TDHS are unknown but recent data suggest poor glycaemic control is associated with poor outcome. Treatment of TDHS requires aggressive surgery. Hence, preventive efforts for both foot and hand sepsis include aggressive glucose control, and education on hand and foot care and the importance of seeking medical attention promptly at the earliest onset of symptoms
authors.affiliation: Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania, Liverpool School of Tropical Medicine, Liverpool, UK.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Abbas
authors.forename: G V
authors.initials: GV
authors.lastname: Gill
authors.forename: L K
authors.initials: LK
authors.lastname: Archibald
mesh_terms: D000328:Adult; D000349:Africa / Q000453:epidemiology; D017719:Diabetic Foot / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy; D003929:Diabetic Neuropathies / Q000453:epidemiology*; D006225:Hand / Q000294:innervation; D006801:Humans; D006920:Hygiene; D010353:Patient Education as Topic; D018805:Sepsis / Q000453:epidemiology* / Q000517:prevention & control / Q000628:therapy; D013577:Syndrome