[Leptin: regulatory role in bone metabolism and in inflammation].
Leptin is a peptidic molecule synthesized almost exclusively by adipocytes, that regulates appetite and energy expenditure at the hypothalamic level. In the last few years, further actions have been attributed to this molecule, as modulating the immune response and affecting the bone metabolism. We have reviewed if leptin contributes to the metabolic changes leading to cachexia and to the regulation of inflammation, paying attention to the pathogenetic mechanisms of chronic arthritis. Besides, considering the relationship between body mass index (BMI) e bone mineral density (BMD) and the protective role of the obesity towards osteoporosis, we have analysed the role of leptin on the bone metabolism
De Marchi
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Cattedra e Clinica di Reumatologia, Policlinico Universitario a Gestione Diretta, Università degli Studi di Udine. genevre@tin.it
Ferraccioli
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D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D001168:Arthritis / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002100:Cachexia / Q000378:metabolism; D004195:Disease Models, Animal; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D020738:Leptin / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000145:classification / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D054411:Receptors, Leptin
C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C515447:leptin receptor, mouse