title: Immune regulation by histamine.
abstract: Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions. In addition to its well-characterised effects in the acute inflammatory and allergic responses, histamine regulates several aspects of antigen-specific immune response development. Histamine affects the maturation of dendritic cells and alters their T cell-polarising capacity. Histamine also regulates antigen-specific T helper 1 and T helper 2 cells, as well as related antibody isotype responses. Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals.
authors.affiliation: Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland. marek.jutel@siaf.unizh.ch
authors.forename: Marek
authors.initials: M
authors.lastname: Jutel
authors.forename: Takeshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Mübeccel
authors.initials: M
authors.lastname: Akdis
authors.forename: Kurt
authors.initials: K
authors.lastname: Blaser
authors.forename: Cezmi A
authors.initials: CA
authors.lastname: Akdis
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D006632:Histamine / Q000276:immunology / Q000502:physiology*; D007107:Immune System / Q000276:immunology / Q000502:physiology*; D051379:Mice; D009000:Monocytes / Q000276:immunology / Q000502:physiology; D011968:Receptors, Histamine / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
chemical_list: D011968:Receptors, Histamine; D006632:Histamine