title: Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway.
abstract: The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This efficient cellular uptake pathway has been exploited for the site-specific delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that overexpress the transferrin receptors. This is achieved either chemically by conjugation of transferrin with therapeutic drugs, proteins, or genetically by infusion of therapeutic peptides or proteins into the structure of transferrin. The resulting conjugates significantly improve the cytotoxicity and selectivity of the drugs. The coupling of DNA to transferrin via a polycation or liposome serves as a potential alternative to viral vector for gene therapy. Moreover, the OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain.
authors.affiliation: Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong. bczmqian@polyu.edu.hk
authors.forename: Zhong Ming
authors.initials: ZM
authors.lastname: Qian
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.forename: Hongzhe
authors.initials: H
authors.lastname: Sun
authors.forename: Kwokping
authors.initials: K
authors.lastname: Ho
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D016503:Drug Delivery Systems; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011990:Receptors, Transferrin / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D014168:Transferrin / Q000737:chemistry / Q000378:metabolism / Q000502:physiology
chemical_list: D004364:Pharmaceutical Preparations; D011990:Receptors, Transferrin; D014168:Transferrin