[Secondary changes in the thyroid gland induced by aspiration cytology].
Due to the introduction of fine needle aspiration cytology (FNAC) to the routine clinical preoperative examination surgical pathologists are faced with thyroid gland specimens with FNAC-induced secondary changes. These changes can cause diagnostic difficulties and be a source of incorrect diagnosis. Authors present a review of FNAC-induced changes with differential diagnostic criteria helpful in these pitfalls. FNAC-induced changes can be schematically divided into two major groups--recent ones (intranodal bleeding and/or necrosis) and subacute/late ones (proliferation of granulation tissue with predominance of myofibroblasts or endothelial cells, resorptive pseudoxantomathous granulomas, formation of sarcoid-like granulomas, capsular pseudoinvasion and scarring). Pathologists should be informed about the previously performed FNAC and must be aware of these lesions to prevent their misinterpretation.
Ryska
A
A
Fingerlandův ústav patologie, Lékarská fakulta UK a Fakultní nemocnice, Hradec Králové.
Ludvíková
M
M
Kholová
I
I
Cáp
J
J
D001707:Biopsy, Needle / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D013961:Thyroid Gland / Q000473:pathology*