title: Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro.
abstract: Twenty-seven oxygenated xanthones have been assessed for their capacity to inhibit in vitro the growth of three human cancer cell lines, MCF-7 (breast cancer), TK-10 (renal cancer) and UACC-62 (melanoma). The effect of these xanthones on the proliferation of human T-lymphocytes was also evaluated. Differences on their potency towards the effect on the growth of the human cancer cell lines as well as on the proliferation of human T-lymphocytes can be ascribed to the nature and positions of the substituents on the xanthonic nucleus.
authors.affiliation: Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto, Faculdade de Farmácia, Porto, Portugal. madalena@ff.up.pt
authors.forename: Madalena
authors.initials: M
authors.lastname: Pedro
authors.forename: Fátima
authors.initials: F
authors.lastname: Cerqueira
authors.forename: Maria Emília
authors.initials: ME
authors.lastname: Sousa
authors.forename: Maria São José
authors.initials: MS
authors.lastname: Nascimento
authors.forename: Madalena
authors.initials: M
authors.lastname: Pinto
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014966:Xanthenes / Q000138:chemical synthesis / Q000494:pharmacology*; D044004:Xanthones
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D010835:Phytohemagglutinins; D014966:Xanthenes; D044004:Xanthones; C009689:xanthone