Non-electrical functions of neurons.
Classical histological preparations of metasympathetic nervous system impregnated with silver salts were compared with the dynamics of the development of plexuses in cultures of isolated neurons and electron microscopic studies to investigate the non-electrical properties of neurons. Two modes of neurite contraction were demonstrated, along with a means of translocation of the neuron soma within neurites, and formation of tail processes and autotomy. It is hypothesized that nerve receptor endings have tissue trophic effects, with autoamputation of terminals with subsequent activation of their lysosomal proteases, which appear to be growth factors for surrounding tissues. The morphogenetic functions of neurocytes are analyzed and evidence is presented for the occurrence of constant reconstruction of previously formed plexuses in healthy adult animals.
Sotnikov
O S
OS
Laboratory for the Functional Morphology and Physiology of Neurons, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
D000818:Animals; D001921:Brain; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D008195:Lymnaea; D008854:Microscopy, Electron; D009414:Nerve Growth Factors / Q000502:physiology; D009415:Nerve Net; D016501:Neurites / Q000502:physiology / Q000648:ultrastructure; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure*; D017729:Presynaptic Terminals / Q000000981:diagnostic imaging / Q000502:physiology; D013997:Time Factors; D014463:Ultrasonography
D009414:Nerve Growth Factors