Markers of coagulation, fibrinolysis and angiogenesis after strenuous short-term exercise (Wingate-test) in male subjects of varying fitness levels.
It was the aim of the study to analyse the haemostatic system during a high standardized intensive short-term (30 s) exercise (anaerobic Wingate test). Blood samples were taken from 15 male subjects before (t0 ), and within 2 (t1 ), 9 (t2 ) and 30 min (t3 ) after the test. We found that the partial thromboplastin time was markedly shortened, whereas the prothrombin time increased slightly from t0 to t1 (p < 0.002) and remained elevated (t3, p < 0.046). Factor VIII increased from t0 to t1 (p < 0.001) and remained elevated as well (t3, p < 0.001). Fibrin monomers were approximately 15 times higher immediately post-exercise (t1, p < 0.001) and continued to be elevated (t3, p < 0.004). The tissue plasminogen activator increased by 4 times after exercise (t1, p < 0.001) and remained elevated (t3, p < 0.002). The d-dimers increased from t0 to t1 (p < 0.001) as well and remained elevated (t3, p < 0.005). Thrombopoietin concentrations were unchanged, whereas the vascular endothelial growth factor increased immediately post-exercise (t0 to t1, p < 0.011 resp. at t2 p < 0.019) and returned to the control level at t3 (p < 0.878). In conclusion, it was found that prothrombotic markers and, even more pronounced, those of the fibrinolytic system were increased. The study provides evidence that due to intensive short-term exercise the balance of the haemostatic system is shifted to a higher equilibrium. Theoretically, the data show that in the case of a subject with risk factors such as impaired fibrinolysis, unfavourable conditions cannot be excluded.
Gunga
H-C
HC
Department of Physiology, Center of Space Medicine, Free University of Berlin, Clinical Center Benjamin Franklin, Berlin, Germany. Gunga@zedat.fu-berlin.de
Kirsch
K
K
Beneke
R
R
Böning
D
D
Hopfenmüller
W
W
Leithäuser
R
R
Hütler
M
M
Röcker
L
L
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001777:Blood Coagulation / Q000502:physiology*; D001780:Blood Coagulation Tests; D005080:Exercise Test; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness; D018709:Statistics, Nonparametric
D015415:Biomarkers