[The influence of bioceramics on phagocytosis of human leukocytes].
BACKGROUND
After implantation of biomaterials in the regions of head and neck with resident microbial contamination the interaction between the implant and microbes play an important role for the success of the implantation. The host immune defence is important for the outcome after implantation, too. Phagocytosis plays an important role in the human immune response on infections.


METHODS
The method described by Suess was used to investigate and measure the influence of the bioceramics Bioverit((R)) and Al(2)O(3)-ceramic on phagocytosis of yeast by human leukocytes.


RESULTS
The bioceramics showed no statistically significant influence on phagocytosis function by human leukocytes. There was a tendency towards lower phagocytosis rates in all samples with bioceramics.


CONCLUSIONS
The bioceramics Bioverit((R)) and Al(2)O(3) ceramic have no influence on phagocytosis of human leukocytes. In conclusion these biomaterials did not cause any inhibition of this important part of the human immune response on microbial infections after alloplastic implantation in head and neck regions.
Koscielny
S
S
HNO-Klinik der Friedrich-Schiller-Universität Jena, Germany. Sven.Koscielny@med.uni-jena.de
Beleites
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E
D000328:Adult; D000537:Aluminum Oxide; D002516:Ceramics; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000276:immunology / Q000601:surgery*; D010587:Phagocytosis / Q000276:immunology*; D019919:Prosthesis Implantation; D012441:Saccharomyces cerevisiae / Q000276:immunology; D013530:Surgical Wound Infection / Q000276:immunology
C067324:Bioverit; D000537:Aluminum Oxide