title: Nitric oxide synthase: use of stopped-flow spectroscopy and rapid-quench methods in single-turnover conditions to examine formation and reactions of heme-O2 intermediate in early catalysis.
authors.affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Chin-Chuan
authors.initials: CC
authors.lastname: Wei
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Stuehr
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001894:Borohydrides / Q000737:chemistry; D002384:Catalysis; D019281:Dimerization; D004227:Dithionite / Q000737:chemistry; D006900:Hydroxylation; D007501:Iron / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000737:chemistry / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D001894:Borohydrides; D004227:Dithionite; D009569:Nitric Oxide; D001120:Arginine; D007501:Iron; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D010100:Oxygen