Distinct functions of COX-1 and COX-2.
The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-1 (COX-1) and COX-2. The properties of COX-1 are different from those of COX-2. It was originally thought that the function of COX-1 was involved in physiological phenomena, whereas that of COX-2 was involved in various pathologies. However, studies with COX-2 knockout mouse suggest that COX-2 also plays important roles in development and homeostasis. This chapter focuses on the distinct functions of COX-1 and COX-2.
Morita
Ikuo
I
Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan. morita.cell@dent.tmd.ac.jp
D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008565:Membrane Proteins; D009369:Neoplasms / Q000378:metabolism; D010641:Phenotype; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism; D014018:Tissue Distribution
D007527:Isoenzymes; D008565:Membrane Proteins; D011453:Prostaglandins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases