Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia.
Extracts of the marine sponge Caminus sphaeroconia showed potent activity in a screen for bacterial type III secretion inhibitors. Bioassay guided fractionation of the extract led to the isolation of the novel antimicrobial glycolipid caminoside A (1). The structure of caminoside A was elucidated by analysis of spectroscopic data and chemical degradation.[structure: see text]
Linington
Roger G
RG
Department of Chemistry, University of British Columbia, Vancouver, B.C., V6T 1Z1, Canada.
Robertson
Marilyn
M
Gauthier
Annick
A
Finlay
B Brett
BB
van Soest
Rob
R
Andersen
Raymond J
RJ
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification*; D002236:Carbohydrate Conformation; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification*; D008958:Models, Molecular; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D000890:Anti-Infective Agents; D003503:Cyclobutanes; D006017:Glycolipids; D013449:Sulfonamides; C469706:triethylmethylsulfinamide; D005947:Glucose; C058254:sibutramine