Study on the distribution of nodularin in tissues and cell level in mice.
OBJECTIVE
To study the tissue distribution of nodularin in mice and the cellular location of nodularin in the target organs.


METHODS
The nodularin was labeled with radioactive isotope (125)I and then was given to mice via oral, intraperitoneal and intravenous administration. The distribution of nodularin in target organs and the cellular location of nodularin were studied by radioisotope and autoradiography techniques.


RESULTS
The radioisotope study results showed that nodularin was mainly distributed in the kidney and liver in mice. Further autoradiography study indicated that nodularin was distributed in the renal cell nuclei and liver cell nuclei.


CONCLUSIONS
The kidney and liver are the two main target organs for nodularin in mice.
Zhang
Zhanying
Z
Institute of Preventive Medicine, School of Public Health, Fudan University, Shanghai 200032, China.
Yu
Shunzhang
S
Chen
Chuanwei
C
Wei
Guorong
G
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008387:Marine Toxins / Q000493:pharmacokinetics*; D051379:Mice; D010456:Peptides, Cyclic / Q000493:pharmacokinetics*
D008387:Marine Toxins; D010456:Peptides, Cyclic; C063998:nodularin