title: [Comparison of effectiveness of endoscopic injection of autologous blood and conservative therapy in the treatment of bilateral primary vesicoureteral reflux].
abstract: Vesicoureteral reflux (VUR) is one of the most frequent diseases which leads to pyelonephritis and furthermore, renal damage. The treatment of VUR (surgical or endoscopic) remains a controversial topic. Autologous blood injection--autohemotherapy (AHT) is used in the endoscopic treatment of VUR. The aim of the research was the comparison of efficacy of AHT and conservative therapy in children with bilateral VUR grade III. 125 children were treated endoscopically. The results of the AHT were compared with the results of conservative treatment in 121 children with the same kind of disease. Complete disappearance of VUR after AHT was observed in 61.6% of children and in 59.5% after two years of medical treatment. These results were not significantly different (p > 0.73) in contrast to the results reached after one year of conservative therapy (p < 0.01). After the conservative treatment in 33.5% of kidneys reflux nephropathy (NR) was observed. In the group treated by AHT NR developed in 25.2% of kidneys. The frequency of NR was significantly higher in children after conservative treatment (p < 0.001). 29.8% of children after conservative therapy and 8% of children after AHT were operated. The results of research proved that usefulness of intravesical autohemotherapy in the treatment of VUR. The method was safe with a low quantity of complications. The efficacy of AHT in the elimination of bilateral high grade VUR was comparable to this reached after two years of conservative treatment.
authors.affiliation: Slaskiej Akademii Medycznej, Katedry i Kliniki Urologii w Zabrzu.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Paradysz
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Fryczkowski
authors.forename: Zofia
authors.initials: Z
authors.lastname: Krauze-Balwińska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Gajewski
mesh_terms: D001804:Blood Transfusion, Autologous; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011044:Poland; D011704:Pyelonephritis / Q000209:etiology / Q000517:prevention & control; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000628:therapy*