title: Oxidative stress in the mussel Mytella guyanensis from polluted mangroves on Santa Catarina Island, Brazil.
abstract: Digestive glands of the mangrove mussel Mytella guyanensis, collected at one non-polluted site (site 1) and two polluted sites (sites 2 and 3), were analysed for different antioxidant defenses, lipid peroxidation and DNA damage. Thiobarbituric acid-reactive substance (TBARS) and 8-oxo-7,8-dihydro-2'-deoxyguanosine levels were enhanced at the polluted sites. With the exception of superoxide dismutase, the activities of catalase and glutathione peroxidase were also higher at the polluted sites. Greater increases were observed in glutathione reductase, glutathione S-transferase and etoxyresorufine-O-deethylase activities at the polluted sites. Conversely, reduced glutathione content was higher at the control site. Trace metal contents in mussels collected at polluted sites were increased compared to the control site, and there were strong positive correlations between TBARS and Cu and Pb contents. M. guyanensis is routinely exposed to an oxidative stress condition at both polluted sites, and considering xenobiotic bioaccumulation in bivalve molluscs, the mangrove mussel represents an excellent bioindicator for environmental monitoring studies.
authors.affiliation: Departamento de Ecologia e Zoologia, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
authors.forename: Moacir Aloisio
authors.initials: MA
authors.lastname: Torres
authors.forename: Camila Pires
authors.initials: CP
authors.lastname: Testa
authors.forename: Catia
authors.initials: C
authors.lastname: Gáspari
authors.forename: Mariana Beatriz
authors.initials: MB
authors.lastname: Masutti
authors.forename: Clarice Maria Neves
authors.initials: CM
authors.lastname: Panitz
authors.forename: Rozangela
authors.initials: R
authors.lastname: Curi-Pedrosa
authors.forename: Eduardo Alves
authors.initials: EA
authors.lastname: de Almeida
authors.forename: Paolo
authors.initials: P
authors.lastname: Di Mascio
authors.forename: Danilo Wilhelm
authors.initials: DW
authors.lastname: Filho
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D049872:Bivalvia / Q000378:metabolism*; D001938:Brazil; D004249:DNA Damage; D004784:Environmental Monitoring / Q000379:methods*; D005618:Fresh Water; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014876:Water Pollution
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances