title: Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected deer, elk, sheep, and cattle.
abstract: Analysis of abnormal prion protein glycoform patterns from chronic wasting disease (CWD)-affected deer and elk, scrapie-affected sheep and cattle, and cattle with bovine spongiform encephalopathy failed to identify patterns capable of reliably distinguishing these transmissible spongiform encephalopathy diseases. However, PrP-res patterns sometimes differed among individual animals, suggesting infection by different or multiple CWD strains in some species.
authors.affiliation: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Race
authors.forename: Anne
authors.initials: A
authors.lastname: Raines
authors.forename: Thierry G M
authors.initials: TG
authors.lastname: Baron
authors.forename: Michael W
authors.initials: MW
authors.lastname: Miller
authors.forename: Allen
authors.initials: A
authors.lastname: Jenny
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Williams
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D003670:Deer; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics / Q000378:metabolism*; D006031:Glycosylation; D015151:Immunoblotting; D008969:Molecular Sequence Data; D018620:PrPSc Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification; D012608:Scrapie / Q000235:genetics / Q000378:metabolism*; D012756:Sheep; D013045:Species Specificity; D034081:Wasting Disease, Chronic / Q000235:genetics / Q000378:metabolism*
chemical_list: D018620:PrPSc Proteins