A case of coronary spasm induced by 5-fluorouracil.
Cardiotoxicity is an uncommon adverse effect of 5-fluorouracil (5-FU). Coronary artery spasm has been postulated to be involved in the mechanism of this incident Patients may present with angina, myocardial infarction, arrhythmias and/or even sudden death. When the drug is readministered, there is a high risk of relapse. The underlying mechanisms of cardiotoxicity are not yet fully understood, although coronary vasospasm may be responsible. We report one woman receiving 5-fluorouracil therapy with typical chest pain and electrocardiographic changes consistent with acute coronary syndrome. A resolving pain and normalisation of ECG changes with nitrate therapy and normal coronary arteries indicate that this incident was about a coronary spasm caused by 5-FU.
Gorgulu
Sevket
S
Siyami Ersek Thoracic and Cardiovascular Surgery Center, Cardiology Department, Istanbul, Turkey. sevket5@yahoo.com
Celik
Seden
S
Tezel
Tuna
T
D000208:Acute Disease; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002637:Chest Pain / Q000139:chemically induced / Q000175:diagnosis; D003110:Colonic Neoplasms / Q000188:drug therapy; D017023:Coronary Angiography; D003327:Coronary Disease / Q000139:chemically induced* / Q000175:diagnosis; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D013035:Spasm / Q000139:chemically induced* / Q000175:diagnosis; D013577:Syndrome; D017211:Treatment Failure
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil