[Central nervous system germinoma: retrospective study of six cases].
OBJECTIVE
Retrospective analysis of six patients with intracranial germinoma treated in INO and a literature review.


METHODS
Six patients were treated from 1993 to 1998, for histologically verified primary intracranial germinoma. Median age was 18 years (range: 14-26 years). All patients received chemo-radiotherapy (4FP + radiotherapy from 30 to 50 Gy).


RESULTS
4 tumours were in complete remission. Two patients have kept non-evolutive residual cyst. Five patients are alive with non-evolutive disease after 15-40 months of follow-up (average: 27 months). One patient was lost to follow-up, 14 months after treatment, without disease.


CONCLUSIONS
The treatment of intracranial germinoma is currently first line chemotherapy followed by low-dose and limited irradiation.
Sifat
H
H
Service de radiothérapie, Institut national d'oncologie, BP 6213 RI-Rabat, Maroc.
Haddadi
K
K
el Ghazi
E
E
Errihani
H
H
Kamouni
M
M
Mansouri
H
H
Hassouni
K
K
Bakkali
H
H
Kanouni
L
L
Gaye
M
M
Kebdani
T
T
Benjaafar
N
N
el Gueddar
B K
BK
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D018572:Disease-Free Survival; D018237:Germinoma / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013997:Time Factors