title: Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat.
abstract: OBJECTIVE
  To evaluate whether or not administration of vitamin B(6) (vitB(6)) has preventive effects on cleft palate formation.
  
  
  METHODS
  On the 14, 15 day of gestation, the pregnant rats were treated with administration of vitB(6) (10 mg/kg weight im) before and simultaneously with dexamethason (DEX). Compared the palatal cleft incidence of their fetuses with those whose mother were given DEX only.
  
  
  RESULTS
  Treatment with administration of vitB(6) before and simultaneously with DEX, the palatal cleft incidence of subject group fetuses (32.35%) was significantly less than that given DEX only (64.52%). The proportion of the palatal cleft type was also changed significantly.
  
  
  CONCLUSIONS
  VitB(6) decrease both the incidence and the severity of cleft palate induced by DEX in rats, which indicates VitB(6) may have preventive effects on cleft palate formation.
authors.affiliation: Center of Cleft Palate, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
authors.forename: Shilei
authors.initials: S
authors.lastname: Zhang
authors.forename: Wenhua
authors.initials: W
authors.lastname: Yuan
mesh_terms: D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced; D005333:Fetus; D010159:Palate; D051381:Rats; D025101:Vitamin B 6; D014815:Vitamins
chemical_list: D014815:Vitamins; D025101:Vitamin B 6