Automated quantitative and qualitative analysis of metabolic stability: a process for compound selection during drug discovery.
Wring
Stephen A
SA
Department of Drug Metabolism and Pharmacokinetics, Trimeris, Inc., Durham, North Carolina 27707, USA.
Silver
Ivin S
IS
Serabjit-Singh
Cosette J
CJ
D000818:Animals; D001331:Automation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004795:Enzyme Stability; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D008660:Metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D015394:Molecular Structure