title: Association of obsessions and compulsions in schizophrenia with neurocognition and negative symptoms.
abstract: It is unclear whether obsessions and compulsions in schizophrenia spectrum disorders are associated with a unique pattern of symptoms and deficits. Accordingly, the present study compared symptom levels and neurocognitive function of participants with schizophrenia or schizoaffective disorder with (n=11) and without (n=52) significant obsessive-compulsive symptoms. Analyses of variance revealed that the obsessive-compulsive group performed more poorly on measures of executive function and vigilance and had higher levels of negative and emotional discomfort symptoms. Unexpectedly, the obsessive-compulsive group also demonstrated superior performance on a measure of visual memory. The implications of these clinical correlates of obsessive-compulsive phenomena in schizophrenia spectrum disorders are discussed.
authors.affiliation: Day Hospital 116H, Roudebush VA Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA. Lysaker.Paul_H_PHD@Indianapolis.va.gov
authors.forename: Paul H
authors.initials: PH
authors.lastname: Lysaker
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Bryson
authors.forename: Kriscinda A
authors.initials: KA
authors.lastname: Marks
authors.forename: Tamasine C
authors.initials: TC
authors.lastname: Greig
authors.forename: Morris D
authors.initials: MD
authors.lastname: Bell
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000175:diagnosis / Q000523:psychology*; D011618:Psychotic Disorders / Q000150:complications* / Q000523:psychology*; D012559:Schizophrenia / Q000150:complications*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires