Transcervical intrauterine topical local anesthetic at hysterosalpingography: a prospective, randomized, double-blind, placebo-controlled trial.
OBJECTIVE
To assess whether transcervical intrauterine topical instillation of a local anesthetic agent reduces pain at hysterosalpingography.


METHODS
Prospective, randomized, double-blind, placebo-controlled study.


METHODS
Department of reproductive medicine at a university teaching hospital.


METHODS
One hundred ten women undergoing hysterosalpingography (HSG).


METHODS
Subjects were randomized to receive either 2 mL of 2% plain lignocaine or 2 mL of 0.9% sodium chloride solution (placebo) topically into the uterine cavity before the HSG was performed.


METHODS
The degree of lower abdominal pain experienced both during the injection of contrast media at HSG and 10 minutes after the procedure using a 20-cm visual analogue scale (VAS) and a four-point verbal descriptor scale (VDS).


RESULTS
There was no difference in pain scores between lignocaine and placebo during the HSG. However, at 10 minutes after the HSG, subjects receiving lignocaine experienced more pain than those on placebo.


CONCLUSIONS
Transcervical intrauterine topical instillation of 2 mL of 2% plain lignocaine does not reduce pain during HSG and may lead to increased pain immediately after the procedure.
Costello
Michael F
MF
School of Women's and Children's Health, Division of Obstetrics and Gynaecology, University of New South Wales, Royal Hospital for Women, Sydney, New South Wales, Australia. mfcostello@unsw.edu.au
Horrowitz
Stephen
S
Steigrad
Stephen
S
Saif
Najwa
N
Bennett
Michael
M
Ekangaki
Abie
A
D000287:Administration, Topical; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002584:Cervix Uteri; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007047:Hysterosalpingography; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D010919:Placebos; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use; D017211:Treatment Failure; D014599:Uterus
D000779:Anesthetics, Local; D010919:Placebos; D012965:Sodium Chloride; D008012:Lidocaine