Efficient routine production of the 18F-labelled amino acid O-2-18F fluoroethyl-L-tyrosine.
A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application.
Hamacher
K
K
Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425, Jülich, Germany. k.hamacher@fz-juelich.de
Coenen
H H
HH
D002851:Chromatography, High Pressure Liquid; D004735:Energy Transfer; D005461:Fluorine / Q000737:chemistry*; D014443:Tyrosine / Q000737:chemistry*
D005461:Fluorine; D014443:Tyrosine