title: No evidence of de novo amyloidosis in recipients of domino liver transplantation: 12 to 40 (mean 24) month follow-up.
abstract: Domino liver transplantation (DLT) has been performed for selected recipients at several centers, but de novo amyloidosis in recipients of livers from patients with familial amyloid polyneuropathy (FAP) remains a serious concern.
  
  
  OBJECTIVE
  To evaluate the occurrence of de novo amyloidosis in recipients of DLT.
  
  
  METHODS
  Seven recipients of FAP livers were followed for clinical and electroneuromyographic signs of FAP and also for de novo amyloid deposition in the gut.
  
  
  RESULTS
  No signs and symptoms of de novo FAP nor any evidence of amyloid deposits in the gut were observed in recipients of DLT after a mean follow-up of 24 [12-40] months.
  
  
  CONCLUSIONS
  Signs and symptoms of FAP do not occur early in recipients of DLT. These livers could therefore be offered to patients suitable for conventional LT, particularly older subjects in whom the event of de novo amyloidosis would seem improbable.
authors.affiliation: Liver Unit, University of São Paulo School of Medicine, Brazil. plbbr@uol.com.br
authors.forename: Paulo Lisboa
authors.initials: PL
authors.lastname: Bittencourt
authors.forename: Claudia Alves
authors.initials: CA
authors.lastname: Couto
authors.forename: Regina Maria Cubero
authors.initials: RM
authors.lastname: Leitão
authors.forename: Sheila Aparecida
authors.initials: SA
authors.lastname: Siqueira
authors.forename: Alberto Queiroz
authors.initials: AQ
authors.lastname: Farias
authors.forename: Paulo Celso Bosco
authors.initials: PC
authors.lastname: Massarollo
authors.forename: Sérgio
authors.initials: S
authors.lastname: Mies
mesh_terms: D000328:Adult; D000682:Amyloid / Q000096:biosynthesis*; D028227:Amyloid Neuropathies, Familial / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
chemical_list: D000682:Amyloid