Complement in allergy and asthma.
The complement system is a vital link between innate and adaptive immunity. Recently, several investigators have implicated the complement anaphylatoxins C3a and C5a as potential effectors in Type 1 hypersensitivity reactions, including urticaria, rhinitis and asthma. Thus, complement activation may synergize with classical IgE mediated responses, and inhibition of complement may prove therapeutic.
Gerard
Norma P
NP
Department of Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Gerard
Craig
C
D000706:Anaphylatoxins / Q000096:biosynthesis / Q000276:immunology; D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D001249:Asthma / Q000276:immunology*; D003167:Complement Activation / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D006967:Hypersensitivity / Q000276:immunology*; D051379:Mice; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement / Q000276:immunology; D018805:Sepsis / Q000276:immunology
D000706:Anaphylatoxins; D015703:Antigens, CD; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement; D003165:Complement System Proteins