title: CDKs and CKIs: molecular targets for tissue remodelling.
abstract: Effective tissue remodelling is essential to the survival of adult organs. Many of the signalling pathways that control these cellular decisions are regulated by nuclear interactions of cell-cycle proteins. Molecules that target cyclin-dependent kinases (CDKs) or CDK inhibitors (CKIs) represent a new class of therapeutic agents that influence tissue remodelling in several organ systems. An understanding of their cell-specific functions is leading to the development of exciting and bold approaches to the treatment cancer, cardiovascular disease and other diseases.
authors.affiliation: Cardiovascular Branch, National Heart, Lung and Blood Institute/National Institutes of Health, Building 10/8C103, 10 Center Drive, Bethesda, Maryland 20892, USA. enabel@nih.gov
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Nabel
mesh_terms: D000818:Animals; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016213:Cyclins / Q000037:antagonists & inhibitors / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014022:Tissue Survival / Q000187:drug effects* / Q000502:physiology
chemical_list: D016213:Cyclins; D004791:Enzyme Inhibitors; D018844:Cyclin-Dependent Kinases