title: Influence of various phosphopeptides of caseins on iron absorption.
abstract: The influence of the origin and kind of caseinophosphopeptide (CPP) on iron absorption was assessed by comparing a commercially available CPP mixture (CPPs) and derived chromatographic fractions with the purified, chemically phosphopeptide of beta-casein [beta-CN(1-25)] using a perfused rat duodenal loop system; gluconate iron was used as control. Only iron complexed to beta-CN(1-25) displayed a better bioavailability than gluconate iron. The results obtained with various chromatographic fractions indicated that phosphopeptides of different origins (alpha(s)- versus beta-caseins) display specific effects. These findings contribute to the explanation of the discrepancy about the role of caseinophosphopeptides on mineral bioavailability in vivo.
authors.affiliation: Laboratoire de Recherches de Technologie Laitière, INRA, 65 rue de Saint Brieuc, F-35042 Rennes Cedex, France.
authors.forename: Saíd
authors.initials: S
authors.lastname: Bouhallab
authors.forename: Vladas
authors.initials: V
authors.lastname: Cinga
authors.forename: Nabil
authors.initials: N
authors.lastname: Aít-Oukhatar
authors.forename: François
authors.initials: F
authors.lastname: Bureau
authors.forename: Dominique
authors.initials: D
authors.lastname: Neuville
authors.forename: Pierre
authors.initials: P
authors.lastname: Arhan
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Maubois
authors.forename: Dominique
authors.initials: D
authors.lastname: Bouglé
mesh_terms: D000818:Animals; D001682:Biological Availability; D002364:Caseins / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D005942:Gluconates / Q000493:pharmacokinetics; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000493:pharmacokinetics*; D013058:Mass Spectrometry; D010446:Peptide Fragments / Q000493:pharmacokinetics; D010748:Phosphopeptides / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002364:Caseins; D005942:Gluconates; D010446:Peptide Fragments; D010748:Phosphopeptides; C412562:caseinophosphopeptide 1-25; D007501:Iron