Pruritic linear papules on a 75-year-old woman: a case of localized Darier-White disease.
Darier-White disease (DWD), commonly called Darier disease or keratosis follicularis, is a genodermatosis seen in clinical practice. It exists more commonly in the generalized form but can present as a localized condition. Localized DWD is a rare entity characterized by epidermal changes that are like those seen in the generalized form but that are confined to a small area of skin. This entity is postulated to result from a postzygotic mutation and has the potential to be transmitted to offspring, which may result in the severe generalized form. We report a case of localized DWD diagnosed after biopsy of a recalcitrant linear dermatitis and discuss the salient features of this condition.
Barfield
Russell Lee
RL
Tripler Army Medical Center, Honolulu, Hawaii, USA.
Barrett
Kimberly R
KR
Moon
Charles M
CM
David-Bajar
Kathleen
K
D000368:Aged; D007644:Darier Disease / Q000473:pathology* / Q000628:therapy; D003872:Dermatitis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011537:Pruritus / Q000175:diagnosis