title: [Study on chemotherapy-induced disorders of glucose metabolism in patients with malignant ovarian tumor].
abstract: OBJECTIVE
  To determine the effect of chemotherapy on glucose metabolism in patients with malignant ovarian tumor.
  
  
  METHODS
  The blood glucose assay and associated clinical materials of 375 cases with malignant ovarian tumor who received chemotherapy from January 1997 to December 2001 were analyzed retrospectively.
  
  
  RESULTS
  Thirty-two cases (8.5%) had elevated fasting blood glucose after chemotherapy. Among them, 14 cases (3.7%) were diagnosed as diabetes mellitus, 9 cases (2.4%) were diagnosed as impaired glucose tolerance. Paclitaxel based chemotherapy seemed to have more opportunity to induce disorders of glucose metabolism than that in cisplatin based chemotherapy (P < 0.05), and this happened most frequently in 1 approximately 3 courses.
  
  
  CONCLUSIONS
  Chemotherapy may induce disorders of glucose metabolism, which most frequently occurred in 1 approximately 3 courses, including impaired glucose tolerance or diabetes mellitus,especially in patients received paclitaxel chemotherapy.
authors.affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Junji
authors.initials: J
authors.lastname: Zhang
authors.forename: Keng
authors.initials: K
authors.lastname: Shen
authors.forename: Jinghe
authors.initials: J
authors.lastname: Lang
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy*; D017239:Paclitaxel / Q000009:adverse effects
chemical_list: D001786:Blood Glucose; D017239:Paclitaxel