title: Computed tomographic image comparison between mediastinal and lung windows provides possible prognostic information in patients with small peripheral lung adenocarcinoma.
abstract: OBJECTIVE
  The purpose of this study was to determine whether the ratio of the area of the mediastinal computed tomographic image to that of the lung computed tomographic image can be a prognostic factor of small peripheral lung adenocarcinoma.
  
  
  METHODS
  We studied the computed tomographic images of 143 patients with primary peripheral lung adenocarcinoma of 30 mm or less in maximum diameter. Two groups were categorized according to the tumor's ratio of the area of the mediastinal computed tomographic image to that of the lung computed tomographic image (tumor's area in the mediastinal computed tomographic image/tumor's area in lung computed tomographic image x 100%), both faint density-type (<50%) and solid-type images (>/=50%). Clinical factors and prognoses of the 2 groups were analyzed.
  
  
  RESULTS
  There were 58 patients with the solid-type tumor image and 85 patients with the faint density-type tumor image. The number of patients with tumor size of less than 20 mm in the faint density-type tumor group (n = 30) was significantly higher than that in the solid-type tumor group (n = 8, P =.008). The 5-year survival of patients with faint density-type tumors was 74.1%, whereas that in patients with solid-type tumors was 54.2% (P =.013). Furthermore, the survival curve of patients with the solid-type computed tomographic image combined with ground-glass opacity was similar to that of patients with the faint density-type image. Multivariate analysis revealed the prognostic influence of the ratio of the area of the mediastinal computed tomographic image to that of the lung computed tomographic image on survival (P =.029, relative risk = 0.48) and showed to be of second highest influence after the N factor.
  
  
  CONCLUSIONS
  It is suggested that the ratio of the area of the mediastinal computed tomographic image to that of the lung computed tomographic image can be a prognostic factor in patients with small peripheral lung adenocarcinoma.
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Boming
authors.initials: B
authors.lastname: Dong
authors.forename: Masami
authors.initials: M
authors.lastname: Sato
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Sagawa
authors.forename: Chiaki
authors.initials: C
authors.lastname: Endo
authors.forename: Katsuo
authors.initials: K
authors.lastname: Usuda
authors.forename: Akira
authors.initials: A
authors.lastname: Sakurada
authors.forename: Shulin
authors.initials: S
authors.lastname: Wu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oyaizu
authors.forename: Itaru
authors.initials: I
authors.lastname: Ishida
authors.forename: Masashi
authors.initials: M
authors.lastname: Handa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality; D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011856:Radiographic Image Enhancement; D016019:Survival Analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed