title: Differential immune response to the variable surface loop antigen of P66 of Borrelia burgdorferi sensu lato species in geographically diverse populations of lyme borreliosis patients.
abstract: We have studied the immune response to a variable surface-exposed loop region of the P66 outer membrane protein from Borrelia burgdorferi sensu lato by using an enzyme immunoassay. Lyme borreliosis populations found in North America and Sweden were preferentially more seroreactive to P66 from their respective regional species, namely, B. burgdorferi sensu stricto and B. garinii and B. afzelii, respectively.
authors.affiliation: Department of Medical Microbiology, Dermatology, and Infection, Lund University, Lund, Sweden.
authors.forename: Katharina
authors.initials: K
authors.lastname: Ornstein
authors.forename: Yngve
authors.initials: Y
authors.lastname: Ostberg
authors.forename: Jonas
authors.initials: J
authors.lastname: Bunikis
authors.forename: Laila
authors.initials: L
authors.lastname: Noppa
authors.forename: Johan
authors.initials: J
authors.lastname: Berglund
authors.forename: Ragnar
authors.initials: R
authors.lastname: Norrby
authors.forename: Sven
authors.initials: S
authors.lastname: Bergström
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins; D001483:Base Sequence; D025065:Borrelia burgdorferi / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D007124:Immunoenzyme Techniques; D008193:Lyme Disease / Q000175:diagnosis*; D008969:Molecular Sequence Data; D018272:Porins / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D013045:Species Specificity
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C107893:Oms66 protein, Borrelia; D018272:Porins; D011994:Recombinant Proteins