Sirolimus attenuates the expression of metalloproteinase-2 and -9 and inhibits intimal hyperplasia following balloon angioplasty.
Waller
J R
JR
Division of Transplant Surgery, Leicester General Hospital, Leicester, UK. julian@waller720.fsnet.co.uk
Bicknell
G R
GR
Nicholson
M L
ML
D000800:Angioplasty, Balloon / Q000009:adverse effects*; D000818:Animals; D004195:Disease Models, Animal; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D020123:Sirolimus / Q000494:pharmacology*; D017539:Tunica Intima / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D017540:Tunica Media / Q000187:drug effects / Q000201:enzymology / Q000473:pathology
D012333:RNA, Messenger; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D020123:Sirolimus