title: Eukaryotic genomes contain a [2Fez.sbnd;2S] ferredoxin isoform with a conserved C-terminal sequence motif.
abstract: Apicomplexan protists contain a single mitochondrial [2Fe-2S] ferredoxin sequence (mtFd) with a highly conserved C-terminal motif, VDGxxpxPH, that distinguishes it from other mtFd, which have heterogeneous C-termini. This isoform of mtFd, called 'type II ferredoxin', is widespread in eukaryotes, some species having two isoforms and others possessing only one. Because of the known modulating role of the C-terminus of type I mtFd during association with itself and other interacting proteins, the presence of a conserved C-terminus in type II mtFd suggests it evolved either as a means for optimized homodimerization or to allow interaction with a highly conserved partner(s) that is yet to be defined.
authors.affiliation: FB Biologie/Parasitologie, Philipps-Universität Marburg, Germany. seeber@mailer.uni-marburg.de
authors.forename: Frank
authors.initials: F
authors.lastname: Seeber
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016782:Apicomplexa / Q000145:classification / Q000235:genetics; D017124:Conserved Sequence / Q000235:genetics* / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism / Q000502:physiology*; D005288:Ferredoxins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D011487:Protein Conformation; D020033:Protein Isoforms; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: C081714:2Fe-2S ferredoxin; D005288:Ferredoxins; D020033:Protein Isoforms