Synthesis of small cyclic peptides via reverse turn induced ring closing metathesis of tripeptides.
A reverse turn induced (gamma/beta-turn) cyclization of tripeptides 1 can be performed in a ring closing metathesis reaction with Grubbs' catalyst to the corresponding cyclic peptides 2. These cyclic peptides may be useful probes as a conformationally constrained mimic of the bioactive conformation of structurally related HIV protease inhibitors.
Prabhakaran
E N
EN
Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India. javediqbaldrf@hotmail.com
Rao
I Nageswara
IN
Boruah
Anima
A
Iqbal
Javed
J
D002942:Circular Dichroism; D003500:Cyclization; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D017433:Protein Structure, Secondary
D009842:Oligopeptides; D010456:Peptides, Cyclic