title: Congenital chondrodysplastic dwarfism with dyshematopoiesis in a holstein calf.
abstract: A holstein calf with congenital chondrodysplastic dwarfism was histopathologically examined. The head of the calf was relatively flat giving a dog-like appearance with its short nose and sloping forehead. Limb bones were dumbbell-like with short diaphysis and hypertrophied metaphyses. Bone marrow was pale, whitish and fatty. In the metaphyseal plates most of chondrocytes were pyknotic with swollen and ghost-like cytoplasm, and were irregularly arranged. Column of calcified cartilage were poorly formed losing comb-like structure. Bone marrow was ischemic with poor hematopoiesis and was moderately replaced by adipose tissue. In articular cartilage, most of chondrocytes were degenerated with ghost-like cytoplasm. Many cartilage canals and occasional bone marrow-like structure were formed. The characteristics lesions of the calf were chondrodysplasia and dyshematopoiesis.
authors.affiliation: Yamanashi Eastern Livestock Hygiene Center, Higashiyatsushiro-gun, Yamanashi, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Naito
authors.forename: Minoru
authors.initials: M
authors.lastname: Maruyama
authors.forename: Koji
authors.initials: K
authors.lastname: Dobashi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Tanimura
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kimura
authors.forename: Makoto
authors.initials: M
authors.lastname: Haritani
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000002:abnormalities / Q000473:pathology; D001842:Bone and Bones / Q000002:abnormalities / Q000473:pathology; D002417:Cattle / Q000002:abnormalities*; D002418:Cattle Diseases / Q000151:congenital* / Q000473:pathology; D019902:Chondrocytes / Q000473:pathology; D004392:Dwarfism / Q000151:congenital* / Q000662:veterinary*; D005260:Female; D017880:Limb Deformities, Congenital / Q000473:pathology / Q000662:veterinary; D010009:Osteochondrodysplasias / Q000151:congenital* / Q000473:pathology / Q000662:veterinary*