[Repair of DNA damage using nucleotide excision repair (NER)--relationship with cancer risk].
DNA damage repair, responsible for maintaining the genome integrity, plays a central role in cancer biology. Individual DNA repair capacity is genetically determined. Inherited defect in nucleotide excision repair (NER) genes leads to three distinct and extremely rare disorders: xeroderma pigmentosum, associated with high risk of skin cancer, Cockayne syndrome, and trichothiodystrophy. The recently identified common polymorphism in several NER genes may also influence a risk of cancer in general population. The review presents current knowledge about a role of genetic variation of NER genes in cancer predisposition.
Butkiewicz
Dorota
D
Zakład Biologii Nowotworów, Centrum Onkologii-Instytut im. M. Skłodowskiej-Curie, Oddział w Gliwicach.
Rusin
Marek
M
Pawlas
Małgorzata
M
Czarny
Małgorzata
M
Chorazy
Mieczysław
M
D000818:Animals; D003057:Cockayne Syndrome / Q000235:genetics; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D011110:Polymorphism, Genetic; D014983:Xeroderma Pigmentosum / Q000235:genetics