title: Late Aspergillus fumigatus endomyocarditis with brain abscess as a lethal complication after heart transplantation.
abstract: We report the case of a 65-year-old male patient who died from lethal Aspergillus fumigatus endomyocarditis and multiple cerebral septic emboli 6 months after cardiac transplantation. This complication developed 4 weeks after diagnosis of bilateral pulmonary aspergillosis, which was immediately treated by surgical removal and intravenous amphotericin B. Preceding colonization with Aspergillus spp was not identified. Primary cytomegalovirus infection (donor+/recipient-) and toxoplasmosis reactivation (donor+/recipient+) occurring at 1 and 2 months post-transplantation were successfully treated.
authors.affiliation: University Clinic for Cardiothoracic Surgery, Department of Surgery, University Clinics Basel, Basel, Switzerland. freuter@uhbs.ch
authors.forename: Florian
authors.initials: F
authors.lastname: Rueter
authors.forename: Hans H
authors.initials: HH
authors.lastname: Hirsch
authors.forename: Franziska
authors.initials: F
authors.lastname: Kunz
authors.forename: Peter
authors.initials: P
authors.lastname: Buser
authors.forename: James M
authors.initials: JM
authors.lastname: Habicht
authors.forename: Holger
authors.initials: H
authors.lastname: Moch
authors.forename: Ursula
authors.initials: U
authors.lastname: Fluckiger
authors.forename: Hans-Reinhard
authors.initials: HR
authors.lastname: Zerkowski
mesh_terms: D000368:Aged; D001228:Aspergillosis / Q000209:etiology* / Q000473:pathology; D001229:Aspergillosis, Allergic Bronchopulmonary; D001232:Aspergillus fumigatus; D001922:Brain Abscess / Q000382:microbiology*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology; D004697:Endocarditis, Bacterial / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D016027:Heart Transplantation / Q000009:adverse effects* / Q000473:pathology; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000382:microbiology* / Q000473:pathology; D013997:Time Factors; D014123:Toxoplasmosis / Q000188:drug therapy / Q000209:etiology