title: [Angina attack caused by 5-fluorouracil infusion--report of a case and review of the literature].
abstract: Cardiac toxicity of 5-fluorouracil (5-FU) has been rarely reported. We encountered a case of angina attack caused by 5-FU. A 58-year-old Japanese woman underwent sigmoidectomy for a sigmoid colon carcinoma with multiple liver metastases. Two months after surgery, she received chemotherapy comprising hepatic arterial infusion of 5-FU. During the 2nd chemotherapy session 7 days after the first, she complained of anterior chest pain. Her electrocardiograms showed elevations of the ST segment in almost all leads, confirming the diagnosis of angina pectoris. Soon after the third chemotherapy session the same type of attack occurred again. The close association of the attacks with 5-FU administration suggested that the angina might have been induced by 5-FU. Further attacks were avoided by discontinuing the 5-FU thereafter. The incidence of cardiac toxicity 5-FU has been reported to be 1.6-7.6%. Labianca et al. found 17 cases of 5-FU-associated cardiopathy, 15 of which were angina pectoris, out of 1,083 patients treated with the drug for various kinds of neoplasm. Analysis of 6 domestic cases including ours revealed that all patient lacked a previous history of cardiac disease except one who had an arrhythmia. There seemed to be no dose-dependent correlation with 5-FU-induced angina. Cardiac events were found even in the earlier phase of chemotherapy. Since 5-FU is widely used in the treatment of a number of gastrointestinal malignancies, one should bear in mind its cardiac toxicity, manifested as angina pectoris.
authors.affiliation: Dept. of Surgery, Utsunomiya Social Insurance Hospital.
authors.forename: Taku
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hosoya
authors.forename: Torao
authors.initials: T
authors.lastname: Aoki
authors.forename: Shin
authors.initials: S
authors.lastname: Saito
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Nihei
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shoji
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Saito
authors.forename: Hideo
authors.initials: H
authors.lastname: Nagai
mesh_terms: D000787:Angina Pectoris / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D012811:Sigmoid Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; D005472:Fluorouracil