Subacute leukencephalopathy after low-dose intrathecal methotrexate in an adolescent heterozygous for the MTHFR C677T polymorphism.
Strunk
Tobias
T
Department of Pediatrics, University of Luebeck Medical School, Germany. tobiasstrunk@yahoo.de
Gottschalk
Stefan
S
Goepel
Wolfgang
W
Bucsky
Peter
P
Schultz
Christian
C
D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects*; D006579:Heterozygote; D006801:Humans; D007278:Injections, Spinal; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects*; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy
D000964:Antimetabolites, Antineoplastic; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008727:Methotrexate