title: Translational repressors in Drosophila.
abstract: Translational regulation is an important aspect of gene regulation, particularly during early development of the fruit fly embryo when transcriptional mechanisms are untenable. Study of pattern formation and dosage compensation has identified several repressors that bind discrete sites in the untranslated portions of target mRNAs. These repressors do not work in isolation - each binds multiple sites in the appropriate mRNA, and the resulting RNA-protein complexes appear to recruit co-repressors by a variety of mechanisms.
authors.affiliation: Howard Hughes Medical Institute, Dept of Molecular Genetics and Microbiology, Box 3657, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Kellie A
authors.initials: KA
authors.lastname: Dean
authors.forename: Aneel K
authors.initials: AK
authors.lastname: Aggarwal
authors.forename: Robin P
authors.initials: RP
authors.lastname: Wharton
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C093437:bru1 protein, Drosophila