Regional differences in the effect of oestrogen on vascular tone in isolated rabbit arteries.
The aim of the study was to assess how oestrogen acutely affects the tone of isolated artery segments from different vascular beds in rabbit. Cumulative concentrations of 17beta-oestradiol were added to ring segments of thoracic aorta, pulmonary artery, ear artery and coronary arteries from adult male rabbits. Coronary arteries precontracted with potassium or the thromboxane agonist, U46619, relaxed to oestrogen (10(-7) to 10(-4) M), whereas oestrogen (10(-8) to 10(-4) M) only caused additional contraction in segments of thoracic aorta and pulmonary artery precontracted with phenylephrine. In the thoracic aorta both the phospholipase C inhibitor NCDC (10(-4) M) and the cyclooxygenase inhibitor indomethacin (10(-5) M) almost completely blocked the contractile effect of oestrogen. In segments of the ear artery, oestrogen caused relaxation only at higher concentrations of oestrogen (10(-5) to 10(-4) M). In conclusion, oestrogen may cause both relaxation and vasoconstriction in different vascular beds, and in the thoracic aorta the contractile effects of oestrogen may be mediated via inositol phosphate-dependent pathways and release of prostaglandins.
Saetrum Opgaard
Ole
O
Department of Pharmacology, College of Medicine, University of California, Irvine 92697-4625, USA.
Duckles
Sue P
SP
Krause
Diana N
DN
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects; D004347:Drug Interactions; D004967:Estrogens / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011651:Pulmonary Artery / Q000187:drug effects; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D004967:Estrogens; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents