title: Effects of non-surgical treatment modalities on peri-implantitis.
abstract: OBJECTIVE
  To evaluate the effects of local-delivery of 25% metronidazol gel and mechanical cleaning using ultrasonic carbon fiber tip on dental implants with peri-implantitis.
  
  
  METHODS
  27 implants with peri-implantitis were randomly assigned to receiving either 25% metronidazol gel treatment or carbon fiber tip ultrasonic scaling. All parameters including plaque index (PLI), probing depth (PD) of pocket, sulcular bleeding index (SBI), and BANA enzyme analysis were measured at baseline, 1, 2, 6 and 12 weeks after treatment.
  
  
  RESULTS
  Statistically significant decrease (P < 0.05) in SBI, BANA test and PLI occurred in both treatment groups at all time intervals compared to baseline. PD had a decreasing tendency in both groups, but only metronidazole group reached statistically significant level (P < 0.05) at 2 and 6 week intervals compared to baseline. None of the treatment modalities produced any side effects on the implant and peri-implant tissues.
  
  
  CONCLUSIONS
  Both 25% metronidazol gel and mechanical cleaning using ultrasonic carbon fiber tip can be safely and effectively used in the treatment of peri-implant diseases.
authors.affiliation: Department of Periodontology, Peking University School of Stomatology, Beijing 100081, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Tang
authors.forename: Caifang
authors.initials: C
authors.lastname: Cao
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Sha
authors.forename: Ye
authors.initials: Y
authors.lastname: Lin
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002244:Carbon; D015921:Dental Implants / Q000009:adverse effects* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D010518:Periodontitis / Q000209:etiology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014465:Ultrasonics
chemical_list: D000890:Anti-Infective Agents; D015921:Dental Implants; D008795:Metronidazole; D002244:Carbon