title: Combined cutting balloon angioplasty and intracoronary beta radiation for treatment of in-stent restenosis: clinical outcomes and effect of pullback radiation for long lesions.
abstract: Intracoronary beta (beta) radiation decreases the incidence of target lesion revascularization after percutaneous intervention (PCI) for in-stent restenosis (ISR). Cutting balloon (CB) angioplasty may also be superior to other percutaneous techniques for the treatment of ISR. We sought to study the outcomes of patients with ISR who underwent both CB angioplasty and intracoronay beta radiation and compare them to patients with ISR who underwent other PCI techniques without concomitant radiation. We also sought to evaluate the safety and efficacy of pullback intracoronary beta radiation for the treatment of long ISR lesions. Between January 2001 and November 2001, 102 patients (mean age = 55 +/- 13 years) with ISR underwent both CB angioplasty and intracoronay beta radiation. beta radiation was delivered using the Beta Cath (Novoste) 30 mm system, and pullback radiation was performed in 41 patients. A comparison group included a total of 393 patients with ISR who underwent other PCI techniques without concomitant intracoronary radiation therapy. Follow-up was obtained in 99 patients (97%) in the CB angioplasty with intracoronary radiation group and 377 patients (96%) in the comparison group. At follow-up, both target vessel revascularization (TVR) and major adverse cardiovascular events (MACE) occurred significantly less in the CB angioplasty with intracoronary radiation group than in the comparison group (7% vs. 18% for TVR, and 14% vs. 24% for MACE; P < 0.05 for both). In the pullback radiation group, TVR was performed in five patients (12%), and MACE occurred in eight patients (20%). A combination of CB angioplasty and intracoronay beta radiation for ISR seems to yield low rates of subsequent target vessel revascularization and adverse cardiac events. In addition, pullback beta radiation using the Beta Cath (Novoste) 30 mm system is safe and can be used to treat long ISR lesions effectively. Further randomized trials are needed to confirm these findings.
authors.affiliation: Division of Cardiology, University of Texas Houston Medical School and Memorial Hermann Hospital, Houston, Texas, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Moustapha
authors.forename: Joseph
authors.initials: J
authors.lastname: Salloum
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Saikia
authors.forename: Hany
authors.initials: H
authors.lastname: Awadallah
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ghani
authors.forename: Stefano
authors.initials: S
authors.lastname: Sdringola
authors.forename: Georges
authors.initials: G
authors.lastname: Schroth
authors.forename: Abid
authors.initials: A
authors.lastname: Assali
authors.forename: Richard W
authors.initials: RW
authors.lastname: Smalling
authors.forename: H V
authors.initials: HV
authors.lastname: Anderson
authors.forename: Oscar
authors.initials: O
authors.lastname: Rosales
mesh_terms: D000787:Angina Pectoris / Q000209:etiology / Q000401:mortality; D000800:Angioplasty, Balloon; D001610:Beta Particles; D001807:Blood Vessel Prosthesis; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality; D010343:Patient Admission; D019919:Prosthesis Implantation; D012086:Reoperation; D015607:Stents; D016019:Survival Analysis; D013781:Texas; D016896:Treatment Outcome