title: Primary mediastinal yolk sac tumor in a 66-year-old woman.
abstract: OBJECTIVE
  To report a rare case of nonseminomatous extragonadal germ cell tumor in a 66-year-old female with primary yolk sac tumor of the mediastinum.
  
  
  METHODS
  A 66-year-old female was admitted to our hospital with a history of chest pain for 1 month. Computerized tomography of the thorax showed a left paracardiac mass adjacent to the aortic arch, left main pulmonary artery and pericardium. Total surgical excision could not be performed, but several biopsies which were taken through a thoracotomy revealed yolk sac tumor of the mediastinum. Systemic chemotherapy was started, but no response was observed and the patient died after one course of chemotherapy.
  
  
  CONCLUSIONS
  Nonteratomatous mediastinal germ cell tumors are virtually nonexistent in women. To our knowledge, this is the oldest female patient with a primary mediastinal germ cell tumor. Chemotherapy was not effective especially in an old patient. We suggest surgery should be considered as primary treatment modality if diagnosis is made at an early stage.
authors.affiliation: Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey. ugurcos@hotmail.com
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.forename: Nazan
authors.initials: N
authors.lastname: Günel
authors.forename: Yesim
authors.initials: Y
authors.lastname: Yildirim
authors.forename: Leyla
authors.initials: L
authors.lastname: Memis
authors.forename: Z Melda
authors.initials: ZM
authors.lastname: Boyacioglu
mesh_terms: D000368:Aged; D002637:Chest Pain / Q000209:etiology; D018240:Endodermal Sinus Tumor / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D014421:Turkey