A study of the ultrastructure and gene location of hereditary gingival fibromatosis.
OBJECTIVE
To ascertain histology changes of hereditary gingival fibromatosis (HGF) and the location of HGF gene.


METHODS
A pedigree analyses of HGF; and the ultrastructure of gingival overgrowth tissue was observed with electron microscopy. The overgrowth of the HGF gene was defined with microsatellite markers.


RESULTS
The connective tissue of HGF consisted of coarse collagen bundles and several kinds of cells arranged abnormally, such as: epithelial cells, smooth muscle cells and so on; the HGF locus had been mapped to chromosome 5q13-q22.


CONCLUSIONS
The gingival pathologic changes resemble "hamartoma"; the findings has implications for identification of the underlying genetic basis of HGF.
Yang
Minghua
M
Department of Periodontology, Affiliated Stomatological Hospital, Medical College of Nanjing University, Nanjing 210008, China.
Zhang
Dongsheng
D
Xiao
Shangxi
S
Huang
Xiaofeng
X
Zheng
Jilie
J
Kong
Xiangyin
X
D002648:Child; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005192:Family Health; D005260:Female; D005351:Fibromatosis, Gingival / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005881:Gingiva / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008854:Microscopy, Electron; D010375:Pedigree