title: Heparin and osteoporosis during pregnancy: 2002 update.
abstract: Although significant bone mass loss is rare during pregnancy, some situations may increase the risk of symptomatic osteoporosis. Heparin may be necessary for a number of pregnant women with systemic lupus erythematosus and antiphospholipid syndrome. The osteopenic effect of heparin is low even during pregnancy, and recent data point to a more favourable profile of low-molecular-weight heparins as compared with unfractionated heparin. Lactation results in a significant increase of calcium demands and may be a higher risk period for women at risk for osteoporosis.
authors.forename: G
authors.initials: G
authors.lastname: Ruiz-Irastorza
authors.forename: M A
authors.initials: MA
authors.lastname: Khamashta
authors.forename: G R V
authors.initials: GR
authors.lastname: Hughes
mesh_terms: D016736:Antiphospholipid Syndrome / Q000188:drug therapy*; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D010024:Osteoporosis / Q000139:chemically induced*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*
chemical_list: D006493:Heparin