Informant reports of changes in personality predict dementia in a population-based study of elderly african americans and yoruba.
OBJECTIVE
The authors conducted a longitudinal, population-based survey of African Americans in Indianapolis, Indiana, and Yoruba in Ibadan, Nigeria, using the Community Screening Interview for Dementia to assess the predictive value of informant reports of changes in personality on incident dementia and Alzheimer disease.


METHODS
In all, 3,021 subjects had informants' reports of changes in personality and dementia status (2,084 subjects residing in Ibadan and 937 subjects residing in Indianapolis).


RESULTS
After adjusting for demographic, cognitive, and functional characteristics in two markedly different populations, socioeconomically and culturally, subjects with changes in personality had approximately twice the odds of having dementia as subjects with no change in personality.


CONCLUSIONS
The finding that in two markedly different populations, personality change is a significant predictor of future dementia, independent of cognition and functional status, should make clinicians particularly sensitive to these reports when they occur in their elderly patients.
Smith-Gamble
Valerie
V
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA. smith-gamble@med.va.gov
Baiyewu
Olusegun
O
Perkins
Anthony J
AJ
Gureje
Oye
O
Hall
Kathleen S
KS
Ogunniyi
Adesola
A
Hui
Siu L
SL
Hendrie
Hugh C
HC
D001741:Black or African American / Q000523:psychology / Q000706:statistics & numerical data; D000368:Aged; D044383:Black People; D003704:Dementia / Q000523:psychology*; D005260:Female; D015577:Geriatric Assessment / Q000706:statistics & numerical data*; D006801:Humans; D007196:Indiana; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D009549:Nigeria; D010554:Personality Disorders / Q000523:psychology*; D011237:Predictive Value of Tests