Solid-phase synthesis of combinatorial libraries based on enatiomerically pure (1S,2S,4R,5S)-4,5-dihydroxycyclohexan-1,2-dicarboxylic acid scaffolds.
The conditions for solid-phase functionalization of the new enantio-pure scaffold 1 to give libraries of general formula 4 have been derived.
Arosio
Daniela
D
Dipartimento di Chimica Organica e Industriale, Università di Milano, Milan, Italy.
Bernardi
Anna
A
Dellavecchia
Donatella
D
Micheli
Fabrizio
F
Pasquarello
Alessandra
A
D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D003509:Cyclohexanecarboxylic Acids