title: Superpulsed CO2 laser treatment of basal cell carcinoma with intraoperatory histopathologic and cytologic examination.
abstract: BACKGROUND
  CO2 laser is currently one of the most versatile and useful laser devices in dermatologic practice in the fields of both cosmetology and oncology. The CO2 laser in a superpulsed mode enables the operator to effect precise and adequate vaporization of the affected area, with the possibility to appreciate visually the depth achieved, and, when necessary, to perform histologic and cytologic examination of the surrounding skin.
  
  
  OBJECTIVE
  To show superpulsed CO2 laser treatment of basal cell carcinoma.
  
  
  METHODS
  One hundred forty patients presenting single, multiple, superficial, or nodular basal cell carcinoma (BCC) have been treated with the superpulsed CO2 laser. Before the laser treatment the lesion was subjected to cytologic examination by scraping; this examination was then repeated when the papillary dermis was clinically detectable, and again when the operator considered the BCC completely vaporized. In selected subjects, histopathologic examination was done three times (biopsies were obtained at the same time as the samples for the cytologic examination).
  
  
  RESULTS
  Recovery time was fast, with good healing outcomes. After 3 years follow-up no recurrences were seen. The cytologic and histopathologic examinations showed BCC in the specimens obtained prior to and during laser therapy, but not in those obtained after laser therapy.
  
  
  CONCLUSIONS
  This technique causes minimal thermal cellular damage and no severe morphologic cellular alterations. Thus it permits an intraoperatory cytologic and histopathologic examination. Finally, this technique enables the operator to recognize the different skin levels removed by vaporization and to stop the vaporization as soon as unaffected dermis has been reached, as shown by intraoperatory cytologic and histopathologic examination.
authors.affiliation: Department of Dermatology, University of Florence, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Campolmi
authors.forename: Benedetta
authors.initials: B
authors.lastname: Brazzini
authors.forename: Carmelo
authors.initials: C
authors.lastname: Urso
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ghersetich
authors.forename: Luciano
authors.initials: L
authors.lastname: Mavilia
authors.forename: Jana
authors.initials: J
authors.lastname: Hercogova
authors.forename: Torello
authors.initials: T
authors.lastname: Lotti
mesh_terms: D002245:Carbon Dioxide; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007432:Intraoperative Period; D053685:Laser Therapy / Q000379:methods*; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide