Mechanisms of enzymatic CbondO bond cleavages in deoxyhexose biosynthesis.
In the past few years, significant progress has been made in our understanding of the biosynthesis of deoxyhexoses. Mechanistic studies have revealed how enzymes can cleave CbondO bonds of a hexose substrate to make unusual sugars. The increasing amount of knowledge about the biosynthesis of deoxysugars may allow the assembly of a repertoire of novel sugar structures through recruitment and collaborative action of genes from a variety of biosynthetic pathways to create diverse secondary metabolites in our search for novel antibiotic/antitumour agents.
He
Xuemei
X
Division of Medicinal Chemistry, College of Pharmacy, Department of Chemistry and Biochemistry, University of Texas, Austin 78712, USA.
Liu
Hung-wen
HW
D003837:Deoxy Sugars / Q000096:biosynthesis* / Q000737:chemistry*; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D006601:Hexoses / Q000096:biosynthesis* / Q000737:chemistry*; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism
D003837:Deoxy Sugars; D004798:Enzymes; D006601:Hexoses; D010100:Oxygen