Morphological changes of the arterial systems in the kidney under prolonged continuous flow left heart bypass.
We investigated morphological changes of the arterial systems in the kidneys under prolonged continuous flow left heart bypass. Twelve goats were subjected to 2 weeks of pulsatile left heart bypass followed by 4 weeks of continuous flow left heart bypass (group CF). After autopsy, the kidneys underwent pathological evaluation. Six normal healthy goats were used as controls. The media of the afferent arterioles of group CF were frequently thickened by an increase in the number of the mature smooth muscle cells (SMCs). The juxtaglomerular areas (JGA) were expanded because of an increase in the number and size of SMCs and/or SMC-like cells. Furthermore, the percentage of anti-proliferating cell nuclear antigen antibody-positive cells in the JGA of group CF (9.9 +/- 1.9%) was significantly higher (p = 0.025) than that of the control group (4.6 +/- 3.4%), indicating active proliferation in group CF. We concluded that prolonged continuous flow left heart bypass causes proliferation of SMCs and/or SMC-like cells in the afferent arterioles and their perivascular tissue.
Ohnishi
Hiroyuki
H
Department of Artificial Organs, National Cardiovascular Research Institute, Osaka, Japan. hohnishi@ri.ncvc.go.jp
Itoh
Tsuyoshi
T
Nishinaka
Tomohiro
T
Tatsumi
Eisuke
E
Fukuda
Toshihide
T
Oshikawa
Mitsuo
M
Shioya
Kyoko
K
Tsukiya
Tomonori
T
Takewa
Yoshiaki
Y
Homma
Akihiko
A
Uesho
Kunihiro
K
Sato
Koichi
K
Takano
Hisateru
H
Taenaka
Yoshiyuki
Y
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology* / Q000628:therapy*; D004195:Disease Models, Animal; D006041:Goats; D018611:Heart Bypass, Left; D006439:Hemodynamics / Q000502:physiology; D007606:Juxtaglomerular Apparatus / Q000473:pathology / Q000503:physiopathology; D011673:Pulsatile Flow / Q000502:physiology; D012077:Renal Artery / Q000473:pathology* / Q000503:physiopathology; D012079:Renal Circulation / Q000502:physiology; D013997:Time Factors; D017540:Tunica Media / Q000473:pathology / Q000503:physiopathology