Perfusion MRI abnormalities in the absence of diffusion changes in a case of moyamoya-like syndrome in neurofibromatosis type 1.
We report on a 12-year-old boy with neurofibromatosis type 1 who suffered a transient ischemic attack. Angiography revealed occlusion of intracranial arteries, moyamoya vessels and leptomeningeal collaterals. The conventional T2-weighted and the diffusion-weighted MRI images demonstrated no pathology. Dynamic first-pass postgadolinium T2* perfusion-weighted MRI depicted altered hemodynamics in the vascular territory of the left middle cerebral artery, which defined this region as ischemic tissue at risk. The patient suffered a repeat transient ischemic attack 5 days later.
El-Koussy
Marwan
M
Department of Neuroradiology, University of Bern, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.
Lövblad
Karl-Olof
KO
Steinlin
Maja
M
Kiefer
Claus
C
Schroth
Gerhard
G
D002533:Cerebral Angiography; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology; D008297:Male; D009072:Moyamoya Disease / Q000175:diagnosis* / Q000209:etiology; D009456:Neurofibromatosis 1 / Q000150:complications*