title: Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats.
abstract: The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant.
authors.affiliation: Research Institute of Sports Science, Korea University, Seoul, South Korea.
authors.forename: Seong Min
authors.initials: SM
authors.lastname: Ra
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Mi Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Min Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Taeck Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Baek Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Chang Ju
authors.initials: CJ
authors.lastname: Kim
authors.forename: Ee Hwa
authors.initials: EH
authors.lastname: Kim
authors.forename: Kyeong Mi
authors.initials: KM
authors.lastname: Kim
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine; D002455:Cell Division / Q000187:drug effects; D018891:Dentate Gyrus / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012420:Running / Q000502:physiology*; D013550:Swimming / Q000502:physiology*
chemical_list: D009292:Narcotic Antagonists; D009270:Naloxone; D001973:Bromodeoxyuridine