[A palate tumor revealed by pain].
A 41-year-old female presented in April 1996 with a tumor of the hard palate revealed by increasing left palate pain. Adenoid cystic carcinoma was suspected on clinical and imaging data. Two limited surgical procedures showed a tumor histologically made of small lobules of granular cells, PAS positive and expressing S100 protein, infiltrating some medullary spaces of the palatine bone, consistent with a granular-cell tumour. Pain recurred in the territory of the maxillary branch of the left trigeminal nerve (V2). Imaging showed a tumor of the origin of V2-extending through the foramen rotondum. Two radical interventions in September and in October 2000 showed an infiltrating tumor of the V2 and palatine mucosa, with the same histology. There was no immuno-staining for p53, and less than 5% of nuclei expressed Ki67. Malignant Abrikossof tumors are exceptional, morphologically difficult to differentiate from benign ones, only metastasis proving malignancy. Tumor size above 5 cm, recurrence and infiltrative character are considered pejorative. The value of p53 and Ki67 expression remains controversial. We discuss our observation according to these criteria.
Polivka
Marc
M
Service d'Anatomie Pathologique, Hôpital Lariboisière, 2 rue Ambroise, Cedex, France.
Wassef
Michel
M
Lot
Guillaume
G
Herman
Philippe
P
Marsot Dupuch
Kathlyn
K
Prudhomme De Saint Maur
Paul
P
Mikol
Jacqueline
J
D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D010146:Pain; D010157:Palatal Neoplasms / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery / Q000648:ultrastructure; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53