title: Stereospecific synthesis of highly functionalized tricyclic beta-lactams by radical cyclizations using titanocene monochloride.
abstract: The reductive opening of epoxyimonobactams 1 with titanoncene (III) chloride gives rise to radicals that can be trapped by intramolecular pi systems (i.e., conjugated alkenes and lactone and amide carbonyls) in a stereospecific way to give new carbocyclic compounds such as tribactam 2.
authors.affiliation: Departamento de Química Orgánica, Universidad de Salamanca, E-37008 Salamanca, Spain. mgrande@usal.es
authors.forename: Gema
authors.initials: G
authors.lastname: Ruano
authors.forename: Manuel
authors.initials: M
authors.lastname: Grande
authors.forename: Josefa
authors.initials: J
authors.lastname: Anaya
mesh_terms: D004852:Epoxy Compounds / Q000737:chemistry; D005609:Free Radicals; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis*; D009942:Organometallic Compounds; D013237:Stereoisomerism; D047090:beta-Lactams / Q000138:chemical synthesis*
chemical_list: D004852:Epoxy Compounds; D005609:Free Radicals; D006575:Heterocyclic Compounds, 3-Ring; D009942:Organometallic Compounds; D047090:beta-Lactams; C020528:titanocene dichloride