Spectrophotometric determination of sulphacetamide.
A new rapid selective spectrophotometric method for the determination of sulphacetamide is described. The drug forms a orange-yellow colored complex with Cerium(IV) in sulfuric acid media which is extracted into ethyl acetate. The complex exhibits a maximum absorbance at 440 nm with a molar absorptivity of 3 x 10(2) 1 mol-1 cm-1. The system obeys Beer's law in the concentration range of 0.07-1.1 mg of sulphacetamide. The various parameters for the optimum extraction conditions are discussed. The method is applied to the determination of sulphacetamide in dosage forms.
Girdhar
R
R
Pharmacy Department, Faculty of Technology, M.S. University of Baroda, India.
Jain
V K
VK
Menon
S K
SK
Agrawal
Y K
YK
D000891:Anti-Infective Agents, Local / Q000032:analysis*; D002138:Calibration; D002563:Cerium / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D012996:Solutions; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013409:Sulfacetamide / Q000032:analysis*
D000891:Anti-Infective Agents, Local; D007202:Indicators and Reagents; D012996:Solutions; D012997:Solvents; D002563:Cerium; D013409:Sulfacetamide