The 5-HT2 receptor antagonist reduces immobility of mice treated with the atypical antidepressant mianserin in the forced swimming test.
Effects of co-administration with the 5-HT(2) receptor antagonist LY 53857 and the antidepressant mianserin on immobility time in the forced swimming test were investigated in mice. Mianserin did not affect the immobility time at ranges from 1-10 mg/kg, although it elicited anti-immobility effects at 20 mg/kg. Co-administration of the 5-HT(2) receptor antagonist LY 53857 and a subactive dose of mianserin induced apparent anti-immobility effects. Since mianserin facilitates noradrenaline (NA) release from nerve terminals via inhibition of alpha(2) receptors, the blockade of the 5-HT(2) receptor may increase the antidepressant effect of drugs modifying NA levels in the synaptic cleft.
Sugimoto
Yumi
Y
Department of Pharmacology, Kobe Pharmaceutical University, kobe, Japan. yumisugi@kobepharma-u.ac.jp
Yamada
Shizuo
S
Yamada
Jun
J
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology / Q000627:therapeutic use; D004357:Drug Synergism; D004873:Ergolines / Q000494:pharmacology / Q000627:therapeutic use; D007103:Immobilization / Q000502:physiology*; D008124:Locomotion / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008803:Mianserin / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D011985:Receptors, Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D013550:Swimming / Q000502:physiology
D018687:Antidepressive Agents, Second-Generation; D004873:Ergolines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D008803:Mianserin; C032663:LY 53857