title: Serum copper/zinc superoxide dismutase (Cu/Zn SOD) and gastric cancer risk: a case-control study.
abstract: We conducted a case-control study to evaluate the association between serum levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and the risk of gastric cancer. Cases were 214 patients who had been diagnosed with gastric cancer and controls were 120 persons who underwent medical checkups. Serum levels of Cu/Zn SOD were determined by enzyme-linked immunosorbent assay (ELISA). Compared with the lowest quartile, the OR (odds ratio) was 4.54 (95% CI (confidence interval), 1.62 - 12.66) for the third quartile and 15.75 (95% CI, 5.84 - 42.46) for the highest quartile. With both early and advanced cancers, as well as with the intestinal and diffuse types, a significant increase in risk was observed with increasing levels of serum Cu/Zn SOD. Our case-control study showed that serum levels of Cu/Zn SOD were significantly elevated in gastric cancer patients compared with apparently healthy controls, and higher Cu/Zn SOD levels may be associated with an increased risk of gastric cancer.
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan. kikuchis@aichi-med-u.ac.jp
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Obata
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Yagyu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species; D012306:Risk; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000209:etiology; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase