title: Comparison of the effects of buprenorphine, oxymorphone hydrochloride, and ketoprofen for postoperative analgesia after onychectomy or onychectomy and sterilization in cats.
abstract: In this prospective, randomized, blinded study, 68 clinically healthy cats that had onychectomy (n = 20), onychectomy and castration (n = 20), or onychectomy and ovariohysterectomy (n = 28) were randomly assigned to one of four postoperative analgesic treatment groups: buprenorphine (0.01 mg/kg body weight, intramuscularly [IM]), oxymorphone hydrochloride (0.05 mg/kg body weight, IM), ketoprofen (2 mg/kg body weight, IM), and placebo (physiological saline). Sedation scores, visual analog pain scores, cumulative pain scores, serum cortisol concentration, and appetite were used to assess postoperative analgesic effect. Buprenorphine demonstrated the highest efficacy with the lowest cumulative pain scores and serum cortisol levels.
authors.affiliation: Pennsylvania Veterinary Specialty and Emergency Associates, Hickory Veterinary Hospital, Plymouth Meeting 19462, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Dobbins
authors.forename: Nancy O
authors.initials: NO
authors.lastname: Brown
authors.forename: Frances S
authors.initials: FS
authors.lastname: Shofer
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage; D002369:Castration / Q000662:veterinary*; D002415:Cats / Q000502:physiology* / Q000601:surgery*; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007273:Injections, Intramuscular / Q000662:veterinary; D007660:Ketoprofen / Q000008:administration & dosage; D008297:Male; D010111:Oxymorphone / Q000008:administration & dosage; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D011446:Prospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; D007660:Ketoprofen; D010111:Oxymorphone; D006854:Hydrocortisone