title: Analysis of the coxsackievirus B-adenovirus receptor gene in patients with myocarditis or dilated cardiomyopathy.
abstract: Myocarditis and dilated cardiomyopathy (DCM) are common causes of morbidity and mortality in children and adults, most commonly due to infection with coxsackievirus B or adenovirus. Increased expression of the common human coxsackievirus B-adenovirus receptor (CAR) has been reported in patients with DCM. We investigated the CAR gene in patients with acquired or familial myocarditis/DCM for mutations/polymorphisms. Several polymorphisms or intronic substitutions, distant from the intron-exon boundaries, were identified but no mutations. Based upon these data it appears that CAR gene mutations are not a major host determinant in the development of myocarditis and DCM.
authors.affiliation: Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, One Baylor Plaza, Room 333E, , Houston, TX 77030-3411, USA. nbowles@bcm.tmc.edu
authors.forename: Neil E
authors.initials: NE
authors.lastname: Bowles
authors.forename: F
authors.initials: F
authors.lastname: Javier Fuentes-Garcia
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Makar
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Jason
authors.initials: J
authors.lastname: Gibson
authors.forename: Feiris
authors.initials: F
authors.lastname: Soto
authors.forename: Peter L
authors.initials: PL
authors.lastname: Schwimmbeck
authors.forename: Heinz Peter
authors.initials: HP
authors.lastname: Schultheiss
authors.forename: Matthias
authors.initials: M
authors.lastname: Pauschinger
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D002851:Chromatography, High Pressure Liquid; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D004770:Enterovirus / Q000235:genetics; D006801:Humans; D009205:Myocarditis / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D011991:Receptors, Virus / Q000235:genetics*
chemical_list: C568771:CLMP protein, human; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus