title: Interleukin-15 and the regulation of lymphoid homeostasis.
abstract: Interleukin-15 (IL-15) is a cytokine that plays unique roles in both innate and adaptive immune cell homeostasis. While early studies suggested that IL-15 resembled IL-2, more recent work suggests that IL-15 may play multiple unique roles in immune homeostasis befitting its pleiotropic expression pattern. This review will focus on recent studies that highlight some of these functions.
authors.affiliation: Department of Medicine and the Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Avenue MC 6084, Chicago, IL 60637, USA.
authors.forename: James
authors.initials: J
authors.lastname: Lodolce
authors.forename: Patrick
authors.initials: P
authors.lastname: Burkett
authors.forename: Rima
authors.initials: R
authors.lastname: Koka
authors.forename: David
authors.initials: D
authors.lastname: Boone
authors.forename: Marcia
authors.initials: M
authors.lastname: Chien
authors.forename: Faye
authors.initials: F
authors.lastname: Chan
authors.forename: Michelle
authors.initials: M
authors.lastname: Madonia
authors.forename: Sophia
authors.initials: S
authors.lastname: Chai
authors.forename: Averil
authors.initials: A
authors.lastname: Ma
mesh_terms: D000818:Animals; D006706:Homeostasis; D007156:Immunologic Memory; D019409:Interleukin-15 / Q000502:physiology*; D007376:Interleukin-2 / Q000502:physiology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D019409:Interleukin-15; D007376:Interleukin-2; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2