title: [Clinical evaluation of the cause of left ventricular dysfunction in type 2 diabetes without significant cardiac disease].
abstract: OBJECTIVE
  The relationship between left ventricular dysfunction and hypertension or proteinuria was evaluated in type 2 diabetic patients without significant cardiac disease to investigate the cause of diabetic cardiac dysfunction.
  
  
  METHODS
  Twenty-one patients with type 2 diabetes mellitus (mean age 63.8 +/- 7.4 years) underwent left ventriculography and Doppler echocardiography to calculate the ejection fraction and E/A ratio (E/A).
  
  
  RESULTS
  Thirteen patients had hypertension (61.9%) and six patients had proteinuria (28.6%). The E/A was 0.82 +/- 0.21 in all patients. The E/A in patients with hypertension or proteinuria was significantly less than in those without these diseases (0.74 +/- 0.18 vs 0.97 +/- 0.18, p = 0.011; 0.65 +/- 0.10 vs 0.89 +/- 0.20, p = 0.010, respectively). The ejection fraction was 73.3 +/- 7.2% in all patients. The ejection fraction in patients with proteinuria was significantly less than in those without proteinuria (67.6 +/- 10.0% vs 75.5 +/- 4.4%, p = 0.019), but there was no significant difference in ejection fraction between patients with and without hypertension. The duration of diabetes was significantly related to the ejection fraction (r = -0.436, p = 0.048) but not to the E/A.
  
  
  CONCLUSIONS
  In patients with type 2 diabetes without significant cardiac disease, left ventricular diastolic function may be related to both hypertension and proteinuria and left ventricular systolic function may be related to proteinuria and duration of diabetes. Therefore, in addition to hypertension, complications of nephropathy or long duration of diabetes may be related to the cause of the diabetic cardiac dysfunction.
authors.affiliation: Department of Cardiology, Japanese Red Cross Nagasaki Genbaku Hospital, Morimachi 3-15, Nagasaki, Nagasaki 852-8511.
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.forename: Minoru
authors.initials: M
authors.lastname: Hazama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Manabu
authors.initials: M
authors.lastname: Moriya
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ueda
authors.forename: Katsusuke
authors.initials: K
authors.lastname: Yano
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000150:complications; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000209:etiology*