Immunotropic effects of gonadotropin-releasing hormone analog under conditions of emotional painful stress.
Surfagon, a synthetic analog of gonadotropin-releasing hormone injected before emotional painful stress dose-dependently changed the number of antibody-producing cells in rats and phagocytic and functional activities of neutrophils in mice. In castrated animals this peptide increased all studied parameters. This suggests that sex steroids are not involved in the realization of these effects.
Bobyntsev
I I
II
Department of Pathological Physiology, Kursk State Medical Institute. big@ksmu.kursknet.ru
Sever'yanova
L A
LA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005300:Fertility Agents, Female / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology*; D007107:Immune System / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000378:metabolism; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological
D005300:Fertility Agents, Female; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon