Immunoglobulin genes: generating diversity with AID and UNG.
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
Storb
Ursula
U
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
Stavnezer
Janet
J
D000818:Animals; D003564:Cytidine Deaminase / Q000378:metabolism*; D045647:DNA Glycosylases; D005803:Genes, Immunoglobulin; D051379:Mice; D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D051981:Uracil-DNA Glycosidase; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D051981:Uracil-DNA Glycosidase; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase