title: Effect of glatiramer acetate on MS lesions enhancing at different gadolinium doses.
abstract: This baseline-vs-treatment study of 20 patients with relapsing-remitting MS investigated whether glatiramer acetate (GA) has a graduated effect on MS inflammatory activity, which was measured using monthly, standard, and triple dose gadolinium (Gd)-enhanced MRI. GA significantly reduced the mean numbers of enhancing lesions/patient/month on both standard dose and triple dose scans, without interactions with the Gd dose. GA is effective in reducing MS activity, independent of the severity of the MRI-detectable inflammatory process.
authors.affiliation: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rovaris
authors.forename: M
authors.initials: M
authors.lastname: Codella
authors.forename: L
authors.initials: L
authors.lastname: Moiola
authors.forename: A
authors.initials: A
authors.lastname: Ghezzi
authors.forename: M
authors.initials: M
authors.lastname: Zaffaroni
authors.forename: G
authors.initials: G
authors.lastname: Mancardi
authors.forename: E
authors.initials: E
authors.lastname: Capello
authors.forename: F
authors.initials: F
authors.lastname: Sardanelli
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: M
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000293:Adolescent; D000328:Adult; D005682:Gadolinium / Q000008:administration & dosage; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000473:pathology*; D010455:Peptides / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate; D005682:Gadolinium