Percutaneous microwave coagulation therapy for lung cancer.
OBJECTIVE
To evaluate the clinical effect, CT image changes and side-effects of percutaneous microwave coagulation therapy for lung cancer.


METHODS
CT-guided percutaneous puncture was performed using a needle mono-pole microwave antenna with 65W, 2 450 MHz microwave delivered in 60 seconds to 20 peripheral lung cancer patients, including 8 suffering from primary lung cancer and 12 metastatic lung cancer (totally 28 lesions).


RESULTS
Sixteen patients were alive after having been followed-up for 3 approximately 24 months. All patients showed nodules decreased in size. Diminution of over 50% was observed in 13 nodules and 3, completely disappeared. The overall response rate was 57.1%. Ellipsoid shadow 3.5 cm x 2.5 cm across was observed by CT in lesions immediately after coagulation. Gasification within the coagulated area was observed in a week with a high density in the peripheral region. Consolidation was observed in 3 months and the lesion disappeared 1 year later. Complete tumor necrosis was proved by biopsy. No side-effects or complications were observed.


CONCLUSIONS
Percutaneous microwave coagulation therapy is a new safe treatment for lung cancer, giving marked effect but minimum trauma.
Feng
Weijian
W
Department of Medical Oncology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China.
Liu
Wei
W
Li
Caiying
C
Li
Zhigang
Z
Li
Ruxun
R
Liu
Fengling
F
Zhai
Baoe
B
Shi
Jian
J
Shi
Gaofeng
G
D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008872:Microwaves / Q000009:adverse effects / Q000627:therapeutic use*; D013534:Survival; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome