The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site.
The structure of the trypanosomal trans-sialidase reveals a canonical sialidase catalytic site elaborated with a conformational switch that creates an adjacent binding pocket for lactose.
Colman
Peter M
PM
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia.
Smith
Brian J
BJ
D000818:Animals; D002384:Catalysis; D020134:Catalytic Domain; D006023:Glycoproteins; D007785:Lactose / Q000737:chemistry; D008024:Ligands; D009439:Neuraminidase / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D014349:Trypanosoma cruzi / Q000201:enzymology*
D006023:Glycoproteins; D008024:Ligands; D010455:Peptides; C069715:trans-sialidase; D009439:Neuraminidase; D007785:Lactose