A positive look at double-negative thymocytes.
In some respects, our understanding of the cellular and molecular aspects of early T-cell differentiation is lagging behind that of B cells. Papers describing gene-knockout and reporter-transgenic mice in which thymocyte development is affected are often difficult to interpret. Progress in this field will be hampered unless a more detailed phenotypic and molecular analysis of progenitor thymocytes at the single-cell level is carried out.
Ceredig
Rod
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U548 INSERM, CEA-G, 17 rue des Martyrs, F-38054 Grenoble, France. ceredig@dsvsud.cea.fr
Rolink
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D000818:Animals; D015704:CD4 Antigens / Q000032:analysis*; D016827:CD8 Antigens / Q000032:analysis*; D015329:Gene Rearrangement, T-Lymphocyte; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D019009:Proto-Oncogene Proteins c-kit