The toxicological effects of the herbicide 2,4-DCPA on progesterone levels and mortality in Wistar female rats.
The effect of the ester butylglucol of 2,4-Dichlorophenoxyacetic acid (herbicide) on the rate of fertilization and on progesterone levels during gestation in rats, has been studied. The experiments consisted of four groups; one receiving the drug in the drinking water at a concentration of 125 mg/kg/day (the agriculture dose), the second and the third group received per os doses of 50 and 100 mg/kg/day of the herbicide, while the fourth group served as controls. The obtained results show that all treatments lead to a decrease in both indexes of females' fertility and in that of newborn mortality. On the other hand, the index of fertilization has been highly affected by the drug application, with a clear delay in fertilization in animals treated with 100 mg/kg/day and 125 mg/kg/day. Progesterone levels have also been suppressed in individuals receiving the herbicide at 50 and 125 mg/kg/day.
Boulakoud
M S
MS
Département de Biologie, Faculté des Sciences, Université de Annaba BP 12, Annaba 23000, Algerie.
Mosbah
R
R
Abdennour
C
C
Khelili
K
K
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005313:Fetal Death / Q000139:chemically induced; D006540:Herbicides / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000662:veterinary; D011374:Progesterone / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D011374:Progesterone