title: Idiopathic CD4+ T lymphocytopenia associated with disseminated flat warts and alopecia areata.
abstract: Idiopathic CD4+ T lymphocytopenia is a very rare condition characterized by persistent depletion of circulating CD4+ T lymphocytes, without evidence of HIV or HTLV infection, or other identifiable causes of immunodeficiency. The syndrome can present with dermatological diseases, including viral, fungal and bacterial infections, as well as Kaposi's sarcoma, epithelial cell malignancies, lymphoma and inflammatory dermatoses. We report the case of a 47-year-old woman with idiopathic CD4+ T lymphocytopenia who presented with a 10-year history of disseminated and refractory flat warts from which human papillomavirus type 3 DNA was identified. The patient also had alopecia areata.
authors.affiliation: Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Gubinelli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Posteraro
authors.forename: Giampiero
authors.initials: G
authors.lastname: Girolomoni
mesh_terms: D000506:Alopecia Areata / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications*; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications*; D014412:Tumor Virus Infections / Q000150:complications*; D014860:Warts / Q000150:complications* / Q000821:virology