Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph+ adult acute lymphoblastic leukaemia.
We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resulting from this novel translocation, and its possible role in the progression of the leukaemia is discussed.
Specchia
Giorgina
G
Department of Haematology, University of Bari, Italy. emadhba@cimedoc.uniba.it
Albano
Francesco
F
Anelli
Luisa
L
Storlazzi
Clelia Tiziana
CT
Cimino
Giuseppe
G
Liso
Arcangelo
A
Zagaria
Antonella
A
Liso
Vincenzo
V
Rocchi
Mariano
M
D000328:Adult; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D014178:Translocation, Genetic