title: CD1-dependent dendritic cell instruction.
abstract: Both microbial products and T cell factors influence dendritic cell (DC) maturation. However, it is not known which T cells are capable of interacting with DCs at the initiation of adaptive immunity, when foreign antigen-specific T cells are rare. We show here that self-reactive CD1-restricted T cells can promote DC maturation by recognizing CD1 in the absence of foreign antigens. T cell recognition of all four CD1 isoforms can trigger DC maturation, but their distinct mechanisms of costimulation lead to profound differences in concomitant interleukin 12 p70 production. Distinct CD1-reactive T cells may thus differentially direct DC development early in the immune response, thereby controlling subsequent polarization of acquired immunity.
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Vincent
authors.forename: David S
authors.initials: DS
authors.lastname: Leslie
authors.forename: Jenny E
authors.initials: JE
authors.lastname: Gumperz
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Xiong
authors.forename: Ethan P
authors.initials: EP
authors.lastname: Grant
authors.forename: Michael B
authors.initials: MB
authors.lastname: Brenner
mesh_terms: D018949:Antigens, CD1 / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018949:Antigens, CD1