Modulation of orientation and exploratory behavior in mice during development of humoral immune response.
We demonstrated opposite changes in the orientation and exploratory behavior of (CBAxC57Bl/6)F(1) mice in the open field test during the formation of primary humoral immune response. These changes depended on initial behavioral activity: the exploratory behavior was suppressed in animals with initially high activity, stimulated in animals with medium reaction, and remained unchanged in mice with initially low activity. The detected changes in the exploratory behavior during the formation of immune response were leveled in the total population (not divided by initial behavioral status).
Markova
E V
EV
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. evgeniya_markova@mail.ru
Poveshchenko
A F
AF
Korotkova
N A
NA
Yakushenko
E V
EV
Abramov
V V
VV
Kozlov
V A
VA
D000818:Animals; D001522:Behavior, Animal; D016207:Cytokines / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D007107:Immune System; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D017472:Receptors, Interleukin-1 / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012756:Sheep
D016207:Cytokines; D017472:Receptors, Interleukin-1