Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors.
The chiral separation of cyclic Mannich ketones of potential pharmaceutical interest is investigated using HPLC and CE. These Mannich ketones show a marked antibacterial and antifungal activity. In HPLC, stationary phases containing cellulose derivatives or beta-cyclodextrin were used and in CE different cyclodextrins, such as beta-CD, gamma-CD, carboxymethyl-beta-CD and succinyl-beta-CD were added to the background electrolyte as chiral selectors.
Grobuschek
Nina
N
Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Universitätsplatz 1, A-8010 Graz, Austria.
Sriphong
Lawan
L
Schmid
Martin G
MG
Lorànd
Tamàs
T
Aboul-Enein
Hassan Y
HY
Gübitz
Gerald
G
D001681:Biological Assay / Q000295:instrumentation / Q000379:methods; D002482:Cellulose / Q000031:analogs & derivatives*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D008352:Mannich Bases / Q000737:chemistry / Q000302:isolation & purification*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
D003505:Cyclodextrins; D008352:Mannich Bases; D002482:Cellulose