FunSpec: a web-based cluster interpreter for yeast.
BACKGROUND
For effective exposition of biological information, especially with regard to analysis of large-scale data types, researchers need immediate access to multiple categorical knowledge bases and need summary information presented to them on collections of genes, as opposed to the typical one gene at a time.


RESULTS
We present here a web-based tool (FunSpec) for statistical evaluation of groups of genes and proteins (e.g. co-regulated genes, protein complexes, genetic interactors) with respect to existing annotations (e.g. functional roles, biochemical properties, localization). FunSpec is available online at http://funspec.med.utoronto.ca


CONCLUSIONS
FunSpec is helpful for interpretation of any data type that generates groups of related genes and proteins, such as gene expression clustering and protein complexes, and is useful for predictive methods employing "guilt-by-association."
Robinson
Mark D
MD
Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada. m.robinson@utoronto.ca
Grigull
Jörg
J
Mohammad
Naveed
N
Hughes
Timothy R
TR
D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods / Q000706:statistics & numerical data; D030541:Databases, Genetic / Q000145:classification / Q000706:statistics & numerical data; D030562:Databases, Protein / Q000145:classification / Q000706:statistics & numerical data; D005656:Fungal Proteins / Q000145:classification / Q000235:genetics; D005800:Genes, Fungal / Q000235:genetics; D020407:Internet / Q000706:statistics & numerical data*; D005810:Multigene Family; D012984:Software / Q000706:statistics & numerical data
D005656:Fungal Proteins