Adaptations in skeletal muscle disuse or decreased-use atrophy.
Those factors that seem to play some role in inducing adaptations of skeletal muscle in vivo are discussed. The role of myogenesis in maintaining and repairing muscle during atrophic and hypertrophic states is discussed, including pointing out that the modulation of myonuclear number is one means of adapting to varying chronic levels of neuromuscular activity. Finally, we point out the potential consequences of muscle atrophy on the control of movement and the susceptibility to fatigue.
Edgerton
V Reggie
VR
Brain Research Institute, University of California-Los Angeles, Los Angeles, California 90095, USA.
Roy
Roland R
RR
Allen
David L
DL
Monti
Ryan J
RJ
D000222:Adaptation, Physiological; D000818:Animals; D005221:Fatigue / Q000209:etiology; D006801:Humans; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000378:metabolism*; D010641:Phenotype