title: Spanish language mapping using MEG: a validation study.
abstract: The purpose of the present study was to compare magnetoencephalography (MEG) data with the results of the intracarotid amytal procedure (IAP). Twenty-one native Spanish-speaking patients with intractable epilepsy underwent MEG language mapping. A subset of 8 patients also underwent an IAP. With the exception of 2 patients who showed right hemisphere dominance, all other patients showed left hemisphere dominance for language on the MEG recording. The IAP findings were consistent with MEG results in 7 patients. The eighth patient who, according to the MEG data, had probable right hemisphere dominance for language did not show clear hemispheric specialization for language on the IAP and suffered a transient global aphasia following a right temporal lobotomy. These results suggests that MEG-based language mapping can play an important role in presurgical clinical evaluation.
authors.affiliation: Magnetoencephalography Center, Dr. Pérez Modrego, Cognitive Process, Universidad Complutense Madrid, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Maestú
authors.forename: Tomás
authors.initials: T
authors.lastname: Ortiz
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernandez
authors.forename: Carlos
authors.initials: C
authors.lastname: Amo
authors.forename: Pilar
authors.initials: P
authors.lastname: Martin
authors.forename: Santiago
authors.initials: S
authors.lastname: Fernández
authors.forename: Rafael G
authors.initials: RG
authors.lastname: Sola
mesh_terms: D000328:Adult; D000654:Amobarbital; D001037:Aphasia / Q000175:diagnosis / Q000503:physiopathology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004567:Electrodes, Implanted; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007802:Language; D015225:Magnetoencephalography; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology; D011612:Psychosurgery; D011932:Reading; D012815:Signal Processing, Computer-Assisted; D013067:Speech Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000503:physiopathology / Q000601:surgery
chemical_list: D000654:Amobarbital