title: Cytogenic investigations of serious overexposures to an industrial gamma radiography source.
abstract: This paper describes the sequence of events, medical aspects and dose estimations for two radiographers and their driver who were seriously exposed to an iridium-192 industrial radiography source that became detached from its wind-out cable. The men came to medical attention about 1 month later by which time all three were severely leucopenic and one had skin burns on both hands. Doses were estimated by (i) physics calculations combined with their accounts of the event. (ii) the levels of depression of their blood neutrophils, (iii) electron spin resonance on tooth enamel and (iv) blood lymphocyte chromosomal analyses by the conventional dicentric and the fluorescence in situ hybridisation methods. Intercomparison of these methods for estimating doses showed a good level of agreement. In brief, the averaged whole body dose for the most seriously exposed man was about 2.5-3.0 Gy and for the others it was 1.0-2.0 Gy.
authors.affiliation: Medical Radiological Research Centre of RAMS, Obninsk, Kaluga Region, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sevan'kaev
authors.forename: D C
authors.initials: DC
authors.lastname: Lloyd
authors.forename: A A
authors.initials: AA
authors.lastname: Edwards
authors.forename: J E
authors.initials: JE
authors.lastname: Moquet
authors.forename: V Yu
authors.initials: VY
authors.lastname: Nugis
authors.forename: G M
authors.initials: GM
authors.lastname: Mikhailova
authors.forename: O I
authors.initials: OI
authors.lastname: Potetnya
authors.forename: I K
authors.initials: IK
authors.lastname: Khvostunov
authors.forename: A K
authors.initials: AK
authors.lastname: Guskova
authors.forename: A E
authors.initials: AE
authors.lastname: Baranov
authors.forename: N M
authors.initials: NM
authors.lastname: Nadejina
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D005720:Gamma Rays / Q000009:adverse effects*; D006282:Health Personnel; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007496:Iridium Radioisotopes / Q000009:adverse effects; D007953:Leukemia, Radiation-Induced / Q000097:blood / Q000209:etiology / Q000473:pathology*; D007970:Leukopenia / Q000097:blood* / Q000209:etiology / Q000473:pathology; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D011829:Radiation Dosage; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods; D019275:Radiopharmaceuticals / Q000009:adverse effects; D014915:Whole-Body Counting / Q000379:methods*
chemical_list: D007496:Iridium Radioisotopes; D019275:Radiopharmaceuticals