Intratympanic gentamicin injections for Meniere disease: vestibular hair cell impairment and regeneration.
The authors treated 22 patients with intratympanic gentamicin. Vestibular function was measured using caloric and head impulse tests and vestibular evoked myogenic potentials induced by high amplitude sounds and short duration galvanic currents. Roughly one-third of the patients, after initially losing their caloric responses and displaying refixation saccades to head impulse tests, recovered within 2 years of the lesion. Vertigo did not recur in patients in whom the galvanic response was abolished.
De Waele
C
C
Service ORL, Hôpital Lariboisière, Paris, France. cdw@ccr.Jussieu.fr
Meguenni
R
R
Freyss
G
G
Zamith
F
F
Bellalimat
N
N
Vidal
P P
PP
Tran Ba Huy
P
P
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002150:Caloric Tests; D005072:Evoked Potentials, Auditory; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D018069:Hair Cells, Vestibular / Q000473:pathology / Q000502:physiology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009416:Nerve Regeneration; D012438:Saccades; D016896:Treatment Outcome; D014432:Tympanic Membrane
D000900:Anti-Bacterial Agents; D005839:Gentamicins