title: Effects of pollen extract EA-10, P5 on chronic prostatitis or infertility with chronic prostatitis.
abstract: OBJECTIVE
  To determine the drug action mechanism of pollen extract EA-10, P5 on the treatment of chronic prostatitis (CP) or infertility with CP.
  
  
  METHODS
  Malondiadehyde (MDA), superoxide dismutase (SOD), and nitrogen monoxide (NO) were measured by biochemical assay, and zinc content was assayed by atomical spectrophotography in the pre-treatment and post-treatment of CP or infertility with CP.
  
  
  RESULTS
  Compared with control group, leukocytes in expressed protatic secretion (LEPS), MDA, and NO were increased, and zinc content and SOD were decreased significantly in the pre-treatment of CP. After the treatment, LEPS was improved, and MDA and NO were reduced, while zinc content were increased apparently and the alteration of SOD was not evident (P>0.05). In the pre-treatment of infertility with CP, LEPS, MDA, NO, sperm viability, and seminal leukocytes were obviously higher and seminal plasma SOD, zinc content, and sperm motility were obviously lower than those in control group. After the treatment, LEPS, sperm motility, and sperm viability were improved, MDA, NO, and seminal leukocytes were decreased, SOD and zinc content were increased markedly.
  
  
  CONCLUSIONS
  There was inter-correlation between oxygen free radicals (OFR) and occurrence, development, and recovery of CP; Change of OFR may be involved in the drug action mechanism of EA-10, P5 in the treatment of CP or infertility with CP.
authors.affiliation: Institute of Urology, 2nd Affiliated Hospital of Lanzhou medical College, Lanzhou 730030, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Chen
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Wang
authors.forename: Yi-Rong
authors.initials: YR
authors.lastname: Chen
authors.forename: Da-Shan
authors.initials: DS
authors.lastname: Qin
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Fu
authors.forename: Bao-Liang
authors.initials: BL
authors.lastname: Ma
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D011058:Pollen / Q000737:chemistry*; D011472:Prostatitis / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D012434:Secale / Q000737:chemistry; D012661:Semen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D009569:Nitric Oxide; D008315:Malondialdehyde; C010070:cernilton; D013482:Superoxide Dismutase; D015032:Zinc