Antisense oligonucleotides targeting RI alpha subunit of protein kinase A. In vitro and in vivo anti-tumor activity and pharmacokinetics.
Zhang
Ruiwen
R
Division of Clinical Pharmacology, Department of Pharmacology and Toxicology, Comprehensive Cancer Center, Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Wang
Hui
H
D000818:Animals; D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000201:enzymology / Q000628:therapy*; D051379:Mice; D016513:Mice, SCID; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*
D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; D016376:Oligonucleotides, Antisense; C517834:PRKAR1A protein, human; C517835:Prkar1a protein, mouse; D017868:Cyclic AMP-Dependent Protein Kinases