title: CD157, the Janus of CD38 but with a unique personality.
abstract: CD157 is a pleiotropic ectoenzyme which belongs to the CD38 family and to the growing number of leukocyte surface molecules known to act independently as both receptors and enzymes. A 45-kDa surface structure with a GPI anchor, the CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties. CD157 shares several characteristics with CD38, including a similar amino acid sequence and enzymic functions. Both molecules are involved in the metabolism of NAD(+), and the CD157 gene is synthenic on 4p15 with CD38, with which it also shares a unique genomic organization. Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell.
authors.affiliation: Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Turin, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Ortolan
authors.forename: Paola
authors.initials: P
authors.lastname: Vacca
authors.forename: Andrea
authors.initials: A
authors.lastname: Capobianco
authors.forename: Enrico
authors.initials: E
authors.lastname: Armando
authors.forename: Federico
authors.initials: F
authors.lastname: Crivellin
authors.forename: Alberto
authors.initials: A
authors.lastname: Horenstein
authors.forename: Fabio
authors.initials: F
authors.lastname: Malavasi
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000235:genetics / Q000502:physiology*; D051997:ADP-ribosyl Cyclase 1; D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D002448:Cell Adhesion; D058851:GPI-Linked Proteins; D006801:Humans; D008024:Ligands; D008562:Membrane Glycoproteins; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2; C498154:CD38 protein, human; C498155:Cd38 protein, mouse; D051997:ADP-ribosyl Cyclase 1