The role of leptin in the control of body weight.
Physiologic responses to high and low leptin concentrations are strikingly asymmetrical. High concentrations often produce minimal effects, whereas low concentrations provoke strong counterregulatory responses. A model and rationale for the physiology is presented.
Leibel
Rudolph L
RL
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
D000818:Animals; D001835:Body Weight / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D020738:Leptin / Q000502:physiology*; D008297:Male; D051379:Mice; D009765:Obesity / Q000503:physiopathology*
D020738:Leptin