Methotrexate-induced optic neuropathy.
A 53-year-old Caucasian woman with long-standing, well controlled, severe rheumatoid arthritis, treated with methotrexate, salazopyrin, naprosyn, prednisone and plaquenil, presented with progressive visual loss in each eye. She had a past history of non-necrotizing anterior scleritis that was treated with increased doses of prednisone. She developed left then right central scotomas, reduced vision and optic atrophy. Eventually a diagnosis of methotrexate-induced optic atrophy was made.
Balachandran
Chandra
C
Department of Ophthalmology, Royal Prince Alfred Hospital.
McCluskey
Peter J
PJ
Champion
G David
GD
Halmagyi
G Michael
GM
D018501:Antirheumatic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D009896:Optic Atrophy / Q000139:chemically induced*; D009900:Optic Nerve / Q000187:drug effects*; D012607:Scotoma / Q000139:chemically induced; D014792:Visual Acuity / Q000187:drug effects
D018501:Antirheumatic Agents; D008727:Methotrexate