Principles of a topical chemosensory receptor intervention. The basis for a chemosensory CNS medicine.
A topical chemosensory receptor intervention on the level of olfactory receptors is based on a local effect of a chemical molecule (inducer) which triggers a biophysical CNS signaling. The action of the inducer is limited to a temporary contact (receptor imprint) and the molecule is hereafter eliminated (revolving-door effect). The CNS bioresponse is triggered by afferent neuronal signal patterns which effect secondary reactions of endogenous substances and is dissociated from a physical presence of the inducer. The pharmacological mechanism of topical chemosensory receptor intervention is principally different to a systemic administration since it excludes pharmacokinetic components. A descriptive differentiation between a topical chemosensory effect and a systemic drug effect can be determined by application of the relation Teff << TCmax. A chemosensory medicine represents the therapeutic use of a topical chemosensory receptor intervention. It employs chemosensory delivery systems (CDS) and provides for various CNS indications a possibility of more selective, faster and safer effects than a systemic drug administration.
Liedtke
Rainer K
RK
D000287:Administration, Topical; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D002628:Chemoreceptor Cells / Q000187:drug effects*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D012903:Smell / Q000502:physiology