The glitazones: a new treatment for type 2 diabetes mellitus.
The glitazones are a new class of anti-diabetic drugs that act by improving sensitivity to insulin and are indicated in the treatment of type 2 diabetes. The glitazones have effects on carbohydrate and lipid metabolism and hold the promise of being able to influence the many components of the insulin resistance syndrome seen in type 2 diabetes. It is possible that the glitazones may be able to prevent or delay the cardiovascular disease which accompanies type 2 diabetes, long-term studies are required to determine if this is the case. In addition to drug treatment patients with type 2 diabetes should be strongly encouraged to make life style changes which will improve glycaemic control such as weight reduction and increase exercise.
Bradley
Caroline
C
St George's Hospital, London, UK.
D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004304:Dosage Forms; D016903:Drug Monitoring; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D000077205:Pioglitazone; D000077154:Rosiglitazone; D013844:Thiazoles / Q000627:therapeutic use*; D045162:Thiazolidinediones; D006113:United Kingdom
D004304:Dosage Forms; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D000077154:Rosiglitazone; C089946:2,4-thiazolidinedione; D000077205:Pioglitazone