Memory enhancement: the search for mechanism-based drugs.
Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention scores across a broad range of tests and species. Initial clinical results are encouraging. Issues now arise about appropriate applications of candidate drugs and optimal cellular targets for future development.
Lynch
Gary
G
Department of Psychiatry, University of California, Irvine, California 92612, USA. glynch@uci.edu
D000818:Animals; D035843:Biomedical Research; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D015195:Drug Design; D004345:Drug Industry / Q000639:trends*; D006801:Humans; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008569:Memory Disorders / Q000188:drug therapy* / Q000503:physiopathology; D009488:Neurosciences / Q000639:trends*; D018091:Receptors, AMPA / Q000187:drug effects / Q000378:metabolism
D018091:Receptors, AMPA