[Changes of serum sex hormone levels in male workers exposed to cadmium].
OBJECTIVE
To investigate the changes in serum levels of sex hormones in male workers occupationally exposed to cadmium (Cd).


METHODS
Eighty-five Cd-exposed workers in a cadmium refinery in the south China and 76 local healthy subjects as control were selected in the study. Air samples in the workplaces were collected and detected for Cd concentration. Urinary Cd (UCd) level of the workers was measured by graphite atomic absorption spectrometry (AAS) and adjusted by urine level of creatinine (Cr), as an indicator of Cd-burden in the body of all subjects. Also, their serum levels of testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were determined with radioimmunoassay and enzyme immunoassay, respectively, and dose-effect relationship was evaluated.


RESULTS
The serum testosterone levels in Cd-exposure group with 10.9-21.9 and > 21.9 micro mol/mol Cr were 13.00 and 11.37 nmol/L, significantly higher than that (9.31 nmol/L) in those with 0.0-2.2 micro mol/mol Cr. Significantly more increased level of LH (4.11 and 4.32 U/L) was detected in heavy exposure group in the workshop for electrolysis than in control group (2.52 U/L) and in the group with 0.0-2.2 micro mol/mol Cr of UCd (2.64 U/L). No changes in serum level of FSH were found related to Cd exposure.


CONCLUSIONS
Occupational Cd exposure could independently contribute to the changes of serum levels of sex hormone in male workers.
Zeng
Xiangbin
X
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai 200032, China.
Jin
Taiyi
T
Kong
Qinghu
Q
Zhou
Yuanfen
Y
D002104:Cadmium / Q000009:adverse effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D013739:Testosterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D002104:Cadmium; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone