title: [Efficacy and tolerance of Algosteril (calcium alginate) versus Jelonet (paraffin gauze) in the treatment of scalp graft donor sites in children. Results of a randomized study].
abstract: Split skin graft is frequently needed in the treatment of burned patients. Scalp is often free of burns. Due to its good skin quality and important surface, scalp is a very interesting skin donor site, specially in case of children. A controlled, randomised clinical trial was carried out in 10 French Plastic Surgery or Burns Units. It assessed the efficacy and the acceptability of calcium alginate dressing (Algosteril) versus paraffin gauze dressing (Jelonet) in the treatment of scalp donor sites in children. 67 children (mean age 54 months) entered the study, 34 in the alginate group and 33 in the control group. Follow-up visits were on day 2/d3, d5/d6, Day complete healing, d30 and d60 after surgery. The two groups were comparable on inclusion (demographic characteristics, burn nature and surface, donor site surface and thickness of split skin graft). The mean healing time was 10 and 11 days for Algosteril and Jelonet group respectively (ns). The quality of the newly formed tissue was estimated to permit a sooner skin reharvesting in the Algosteril group than in the control group (p = 0.003). Bleeding through dressing was significantly less important in the Algosteril group (p = 0.02). Changes were considered by investigators less painful with Algosteril on day complete healing (p = 0.0096). Hair growth is homogenous in both groups on day 30 and day 60 (ns). These results showed that scalp is a very interesting skin donor site and that Algosteril is of a real interest in donor site treatment.
authors.affiliation: Service des brûlés, hôpital Hôtel-Dieu, Nantes, France. michel.pannier@chu-nantes.fr
authors.forename: M
authors.initials: M
authors.lastname: Pannier
authors.forename: V
authors.initials: V
authors.lastname: Martinot
authors.forename: J C
authors.initials: JC
authors.lastname: Castède
authors.forename: J
authors.initials: J
authors.lastname: Guitard
authors.forename: M
authors.initials: M
authors.lastname: Robert
authors.forename: A
authors.initials: A
authors.lastname: Le Touze
authors.forename: G
authors.initials: G
authors.lastname: Magalon
authors.forename: J M
authors.initials: JM
authors.lastname: Rives
authors.forename: L
authors.initials: L
authors.lastname: Pinheiro
authors.forename: M C
authors.initials: MC
authors.lastname: Romana
authors.forename: H
authors.initials: H
authors.lastname: Carlioz
authors.forename: P
authors.initials: P
authors.lastname: Debeugny
authors.forename: P
authors.initials: P
authors.lastname: Février
mesh_terms: D000464:Alginates / Q000627:therapeutic use*; D001458:Bandages; D001672:Biocompatible Materials / Q000627:therapeutic use; D001684:Biological Dressings; D002056:Burns / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003102:Colloids / Q000627:therapeutic use*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D007223:Infant; D010577:Petrolatum; D012535:Scalp / Q000601:surgery*; D016038:Skin Transplantation; D023001:Transplantation Tolerance
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D003102:Colloids; D006603:Hexuronic Acids; C103734:jelonet; D010577:Petrolatum; D020723:Glucuronic Acid