In vivo gastroprotective effects of five Turkish folk remedies against ethanol-induced lesions.
Through evaluation of the data accumulated in Data Bank of Turkish Folk Remedies (TUHIB), five plant remedies, which are used to treat stomach ache were selected to test for their anti-ulcerogenic potency. In order to confirm the claimed activities, either decoction or methanol extracts were prepared from the roots of Asphodelus aestivus and Cichorium intybus, herbs of Equisetum palustre and Viscum album ssp. album and fruits of Laurus nobilis, according to their folkloric application way and tested for their effects on ethanol-induced gastric ulcer model in rats. Pharmacological experiments clearly demonstrated that the relevant extracts of all the plants given orally showed significant stomach protection against this model of ulcerogenesis. Results were further evaluated by using histopathological techniques.
Gürbüz
Ilhan
I
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, Turkey.
Ustün
Osman
O
Yeşilada
Erdem
E
Sezik
Ekrem
E
Akyürek
Nalan
N
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D019610:Cytoprotection; D005260:Female; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D014421:Turkey
D000897:Anti-Ulcer Agents; D010936:Plant Extracts