Antibodies in human filariasis sera react with diethylcarbamazine.
We demonstrate by an ELISA the presence of antibodies in human filarial sera that react with diethylcarbamazine (DEC); they appear to be primarily filarial antibodies cross-reacting with DEC skeleton, since affinity-purified DEC antibodies strongly react with Wuchereria bancrofti microfilariae. These observations indicate a possible antigenic mimicry between the drug and some parasite component.
Ravindran
B
B
Satapathy
A K
AK
Hussain
T
T
Pattnaik
A M
AM
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood* / Q000302:isolation & purification; D000918:Antibody Specificity; D000947:Antigens, Helminth; D016022:Case-Control Studies; D003429:Cross Reactions; D004049:Diethylcarbamazine / Q000276:immunology*; D005368:Filariasis / Q000276:immunology*; D006801:Humans; D008842:Microfilariae / Q000276:immunology; D018716:Molecular Mimicry; D014958:Wuchereria bancrofti / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D004049:Diethylcarbamazine