Transcatheter patch occlusion of experimental atrial septal defects.
The effectiveness and safety of transcatheter patch atrial septal defect (ASD) occlusion were studied in 20 piglets. Experimental atrial septal defects were created by foramen ovale dilation. ASDs were corrected by polyurethane patches of two types (flat and sleeve). Specially made balloon catheters supported the patches for periods varying from 1 to 6 days; after this period, the supporting catheters were withdrawn and the patches were released. All transcatheter patches were safely embedded in the atrial septum 48 hr or more after implantation. All defects were fully occluded. One patch became infected. The transcatheter patch experimental ASD occlusion method was found effective and safe, potentially applicable in the occlusion of human ASDs.
Sideris
Eleftherios B
EB
Athenian Institute of Pediatric Cardiology, Athens, Greece. terry@hol.gr
Sideris
Chrysoula E
CE
Stamatelopoulos
Stamatis F
SF
Moulopoulos
Spyridon D
SD
D000818:Animals; D001344:Autopsy; D021721:Balloon Occlusion / Q000295:instrumentation* / Q000379:methods; D002408:Catheters, Indwelling; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use; D020878:Device Removal; D004195:Disease Models, Animal; D004452:Echocardiography; D004730:Endothelium, Vascular / Q000473:pathology / Q000601:surgery; D004867:Equipment Design; D004869:Equipment Safety; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000628:therapy*; D006346:Heart Septum / Q000473:pathology / Q000601:surgery; D008955:Models, Cardiovascular; D011183:Postoperative Complications / Q000209:etiology; D013552:Swine; D016896:Treatment Outcome
D020099:Coated Materials, Biocompatible