Plasma anti-oxidant status and lipid profile in non-gravida women with a history of pre-eclampsia.
OBJECTIVE
To investigate the total plasma anti-oxidant status, the plasma lipid profile and the uterine artery Doppler velocity waveform in formerly pre-eclamptic women.


METHODS
Thirty-two formerly pre-eclamptic, non-gravida women constituted the study group, while 28 age-matched non-gravida women who had never had pre-eclampsia served as control subjects. On days 17-19 of their menstrual cycle, fasting plasma samples were collected for total anti-oxidant status (TAS) and lipid profile evaluation, and uterine artery Doppler velocity waveform studies were performed. Results were analyzed with Mann-Whitney U-test and Pearson correlation analysis.


RESULTS
There was no significant difference between the groups in means of the uterine artery Doppler velocity waveforms and the plasma lipid levels, but body mass index values were significant (P < 0.005). The TAS value was subnormal in 72% of the formerly pre-eclamptic group and in 35% of the control group. The mean plasma TAS value was 1.20 +/- 0.05 mmol/L and was significantly lower in the study group when compared with the control group (P < 0.05).


CONCLUSIONS
The current study reveals significantly decreased TAS in women with a history of pre-eclampsia, which may have an important role in pathophysiology.
Ozan
Hakan
H
Department of Obstetrics and Gynaecology, Medical Faculty, Uludağ University, Bursa, Turkey. hozan@superonline.com
Ilçöl
Yeşim
Y
Kimya
Yalçin
Y
Cengiz
Candan
C
Ediz
Bülent
B
D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012039:Regional Blood Flow; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply
D000975:Antioxidants; D008074:Lipoproteins