title: Effective prophylactic protocol in delayed hypersensitivity to contrast media: report of a case involving lymphocyte transformation studies with different compounds.
abstract: A patient with maculopapular reactions to iopamidol needed to undergo angiography for a cerebral arteriovenous malformation. In vivo and in vitro tests were performed with ionic and nonionic contrast media, including iopamidol and iobitridol. All results were positive, demonstrating delayed hypersensitivity. The patient received 6-alpha-methylprednisolone and cyclosporine 1 week before and 2 weeks after four angiograms were obtained with the use of iobitridol, which was well tolerated.
authors.affiliation: Department of Internal Medicine and Geriatrics, Universita' Cattolica del Sacro Cuore, Allergy Unit, Complesso Integrato Columbus, Via G. Moscati 31, 00168 Rome, Italy. columbus.allerg@linet.it
authors.forename: Antonino
authors.initials: A
authors.lastname: Romano
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Artesani
authors.forename: Maria
authors.initials: M
authors.lastname: Andriolo
authors.forename: Marinella
authors.initials: M
authors.lastname: Viola
authors.forename: Rosa
authors.initials: R
authors.lastname: Pettinato
authors.forename: Amorino
authors.initials: A
authors.lastname: Vecchioli-Scaldazza
mesh_terms: D000328:Adult; D002533:Cerebral Angiography; D003287:Contrast Media / Q000009:adverse effects*; D016572:Cyclosporine / Q000008:administration & dosage*; D003875:Drug Eruptions / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D004621:Embolization, Therapeutic; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging* / Q000628:therapy; D007428:Intradermal Tests; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives*; D007479:Iopamidol / Q000009:adverse effects* / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D010328:Patch Tests; D011292:Premedication; D019233:Retreatment
chemical_list: D003287:Contrast Media; D007166:Immunosuppressive Agents; C093233:iobitridol; D007472:Iohexol; D016572:Cyclosporine; D007479:Iopamidol; D008775:Methylprednisolone