[Effect of non-pulsatile blood flow on the secretion of calcitonin-gene-related peptide in patients undergoing total cavopulmonary connection].
OBJECTIVE
To study the changes of calcitonin gene-related peptide (CGRP) in patients who underwent total cavopulmonary connection (TCPC) and to assess the effects of non-pulsatile blood flow on the secretion function of the lung.


METHODS
Twenty-six patients were divided into 2 groups: study group, 13 patients who underwent extracardiac TCPC, and control group, 13 patients who underwent definitive repair for ventricular septal or atrial septal defect. Blood samples for measurement of CGRP were obtained preoperatively, postoperatively or in the follow-up period. Cardiac index (CI) and pulmonary vascular resistance (PVR) were measured by cardiac catheter.


RESULTS
The plasma level of CGRP was significantly higher in the study group than in the control group. CGRP was negatively correlated with PVR (r = -0.99, t = 9.82, P < 0.05), and positively correlation with CI (r = 0.98, t = 6.95, P < 0.05).


CONCLUSIONS
After total right heart bypass, the non-pulsatile blood flow in pulmonary circulation may stimulate the lung to secrete CGRP, leading to the decrease of PVR and improve early postoperative recovery.
Yin
Zongtao
Z
Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zhang
Renfu
R
Wang
Jun
J
Gao
Wengen
W
D000293:Adolescent; D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D018729:Fontan Procedure; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D011652:Pulmonary Circulation; D014655:Vascular Resistance
D015740:Calcitonin Gene-Related Peptide