title: Chemical modification of reveromycin A and its biological activities.
abstract: Various derivatives of reveromycin A, a novel inhibitor of eukaryotic cell growth, were prepared and their inhibitory effects on both isoleucyl-tRNA synthetase activity and in vitro protein synthesis, and activities on the morphological reversion of src(ts)-NRK cells were assayed. The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities.
authors.affiliation: Synthetic Organic Chemistry Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan. tshimizu@postman.riken.go.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Takeo
authors.initials: T
authors.lastname: Usui
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Machida
authors.forename: Kouichi
authors.initials: K
authors.lastname: Furuya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakata
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002461:Cell Line, Transformed; D016391:Genes, src; D020128:Inhibitory Concentration 50; D007533:Isoleucine-tRNA Ligase / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011714:Pyrans; D013141:Spiro Compounds; C068098:reveromycin A; D007533:Isoleucine-tRNA Ligase