Viable but nonculturable Salmonella species recovery and systemic infection in morphine-treated mice.
In vivo recovery and pathogenicity of Salmonella enterica serovar Oranienburg that became viable but nonculturable (VNC) in food were examined. VNC cells were completely eliminated in normal mice but caused systemic bacteremia and were subsequently lethal to morphine-treated mice. Therefore, morphine-treated mice might be a useful bioassay for VNC Salmonella species in implicated food items.
Asakura
Hiroshi
H
Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Watarai
Masahisa
M
Shirahata
Toshikazu
T
Makino
Sou-Ichi
S
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine / Q000494:pharmacology*; D012480:Salmonella Infections / Q000382:microbiology* / Q000401:mortality; D019779:Salmonella enterica / Q000187:drug effects / Q000472:pathogenicity*
D009020:Morphine