title: Type IV secretion and Brucella virulence.
abstract: The type IV secretion system, encoded by the virB region, is a key virulence factor for Brucella. The 12 genes of the region form an operon that is specifically induced by phagosome acidification in cells after phagocytosis. We speculate that the system serves to secrete unknown effector molecules, which allow Brucella to pervert the host cell endosomal pathways and to create a novel intracellular compartment in which it can replicate.
authors.affiliation: INSERM U431, Faculté de Médecine, Avenue Kennedy, 30900 Nîmes, France.
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Boschiroli
authors.forename: Safia
authors.initials: S
authors.lastname: Ouahrani-Bettache
authors.forename: Vincent
authors.initials: V
authors.lastname: Foulongne
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michaux-Charachon
authors.forename: Gisele
authors.initials: G
authors.lastname: Bourg
authors.forename: Annick
authors.initials: A
authors.lastname: Allardet-Servent
authors.forename: Chantal
authors.initials: C
authors.lastname: Cazevieille
authors.forename: Jean-Phillipe
authors.initials: JP
authors.lastname: Lavigne
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Liautard
authors.forename: Michel
authors.initials: M
authors.lastname: Ramuz
authors.forename: David
authors.initials: D
authors.lastname: O'Callaghan
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D002002:Brucella / Q000235:genetics* / Q000472:pathogenicity*; D004268:DNA-Binding Proteins / Q000235:genetics; D011992:Endosomes / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D009876:Operon; D014774:Virulence; D037521:Virulence Factors
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D037521:Virulence Factors