Independent actions on fear circuits may lead to therapeutic synergy for anxiety when combining serotonergic and GABAergic agents.
Both serotonin and GABA powerfully regulate the neuroanatomical circuit that mediates fear in anxiety disorders. This suggests that use of pharmacotherapies acting on both systems may provide synergistic therapeutic actions.
Stahl
Stephen M
SM
Neuroscience Education Institute, Carlsbad, CA 92009, USA.
D000679:Amygdala / Q000187:drug effects; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D004357:Drug Synergism; D005239:Fear / Q000187:drug effects* / Q000502:physiology; D018682:GABA Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D018490:Serotonin Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018682:GABA Agents; D018490:Serotonin Agents; D012701:Serotonin; D005680:gamma-Aminobutyric Acid