title: Geographic distribution of the incidence of adult T-cell leukemia/lymphoma and other malignancies in nagasaki prefecture, Japan.
abstract: BACKGROUND
  It remains unclear whether human T-cell lymphotropic virus type-I (HTLV-I) infection is associated with an increased risk of malignancies other than adult T-cell leukemia/lymphoma.
  
  
  METHODS
  The authors investigated the geographic distribution of the incidence of adult T-cell leukemia/lymphoma and other malignancies in Nagasaki Prefecture, Japan, where HTLV-I is endemic. The world age-standardized incidence rates of adult T-cell leukemia/lymphoma and five cancers of other sites were calculated in 15 areas, using the data from the Nagasaki Prefectural Cancer Registry (1985-97).
  
  
  RESULTS
  The incidence of adult T-cell leukemia/lymphoma was found to be positively correlated with that of biliary tract cancer in men (person-years-weighted r = 0.49, P = 0.06) and liver cancer in women (r = 0.56, P = 0.03), but not with cancer of the stomach, lung or cervix uteri.
  
  
  CONCLUSIONS
  The results may not support the hypothesis that HTLV-I infection is strongly associated with an increased risk of cancer of the stomach, lung or cervix uteri. The association between HTLV-I infection and cancer of the biliary tract and the possible interaction between hepatitis C virus and HTLV-I in the development of liver cancer should be evaluated by prospective cohort studies.
authors.affiliation: Department of Preventive Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Kokichi
authors.initials: K
authors.lastname: Arisawa
authors.forename: Midori
authors.initials: M
authors.lastname: Soda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shirahama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Noboru
authors.initials: N
authors.lastname: Takamura
authors.forename: Maki
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Odagiri
authors.forename: Tohru
authors.initials: T
authors.lastname: Nakagoe
authors.forename: Akihiko
authors.initials: A
authors.lastname: Suyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Doi
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D001661:Biliary Tract Neoplasms / Q000453:epidemiology; D018288:Carcinoma, Small Cell / Q000453:epidemiology; D005260:Female; D005843:Geography; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology*; D008113:Liver Neoplasms / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000453:epidemiology