title: Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging.
abstract: BACKGROUND
  The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of (99m)Tc-sestamibi (MIBI) single photon emission computed tomography (SPECT).
  
  
  RESULTS
  Patients with chronic myocardial infarction defined by enzymes (peak creatine kinase-MB 173+/-119 U/L) were scanned twice by MRI (MRI I and MRI II, n=20) and twice by SPECT (SPECT I and SPECT II, n=15) on the same day. The MRI contrast agent was injected during MRI I but not MRI II to test the effect of imaging time after contrast. Resting Tc-MIBI SPECT images were acquired and infarct size was determined with commercial software. Infarct size in patients scanned by MRI and SPECT was 14+/-6% of left ventricular mass (%LV) by MRI (range 4%LV to 27%LV) and 14+/-7%LV by SPECT (range 4%LV to 26%LV). MRI I and II scans were performed 10+/-2 and 27+/-3 minutes after contrast, respectively. For MRI, the difference in infarct size between scans I and II (bias) was -0.1%LV, and the coefficient of repeatability was +/-2.4%LV. For SPECT, bias was -1.3%LV, and the coefficient of repeatability was +/-4.0%LV. Within individual patients, no systematic differences in infarct size were detected when the 2 MRI scans were compared, the 2 SPECT scans were compared, or MRI was compared to SPECT.
  
  
  CONCLUSIONS
  The size of healed infarcts measured by contrast-enhanced MRI does not change between 10 and 30 minutes after contrast. The clinical reproducibility of contrast-enhanced MRI for infarct size determination compares favorably with that of routine clinical SPECT.
authors.affiliation: Northwestern University Medical School Feinberg Cardiovascular Research Institute, Chicago, Ill, USA.
authors.forename: Heiko
authors.initials: H
authors.lastname: Mahrholdt
authors.forename: Anja
authors.initials: A
authors.lastname: Wagner
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Holly
authors.forename: Michael D
authors.initials: MD
authors.lastname: Elliott
authors.forename: Robert O
authors.initials: RO
authors.lastname: Bonow
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Kim
authors.forename: Robert M
authors.initials: RM
authors.lastname: Judd
mesh_terms: D002908:Chronic Disease; D003287:Contrast Media; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003287:Contrast Media; D017256:Technetium Tc 99m Sestamibi; D003402:Creatine Kinase