[Carbamazepine and aggressive behavior: a review].
Carbamazepine which has been used as an anticonvulsivant for many years, has more recently been advocated for the control of aggressive behavior in epileptic and non epileptic populations. Carbamazepine is the drug of choice for patients whose aggressive outbursts are related to epilepsy. It appears that carbamazepine may also be affective in aggressive individuals with varying diagnoses (especially schizophrenic patients) but additional double-blind studies are needed. Patients experienced good control of aggressive behavior on carbamazepine in doses of 600 to 1,200 mg per day but the relationship of carbamazepine responsiveness to carbamazepine blood levels and concurrent medication (neuroleptic treatment) requires further studies. No significant problem has been encountered in the majority of patients receiving carbamazepine. However, it can rarely cause bone marrow suppression and hepatotoxicity so that blood counts and liver functions require monitoring.
Thibaut
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C.H.S. du Rouvray, 4, rue Paul Eluard, 76301 Sotteville-les-Rouen.
Colonna
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D000374:Aggression; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D010554:Personality Disorders / Q000188:drug therapy*
D000927:Anticonvulsants; D002220:Carbamazepine