title: Did tRNA synthetase classes arise on opposite strands of the same gene?
abstract: Structural homology of class II aminoacyl-tRNA synthetases to the HSP70 family and the existence of a gene whose sense and antisense strands code for a dehydrogenase and an HSP70 chaperonin justify reconsideration of a possible sense-antisense ancestry for the two synthetase classes.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Carter
authors.forename: William L
authors.initials: WL
authors.lastname: Duax
mesh_terms: D000595:Amino Acid Sequence; D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000145:classification* / Q000235:genetics*; D019143:Evolution, Molecular; D005969:Glutamate Dehydrogenase / Q000737:chemistry / Q000235:genetics*; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016372:RNA, Antisense / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D018840:HSP70 Heat-Shock Proteins; D016372:RNA, Antisense; D005969:Glutamate Dehydrogenase; D000604:Amino Acyl-tRNA Synthetases