title: Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.
abstract: We report the synthesis and arraying of 29 400 structurally diverse and complex polycyclic carbocycles using diversity-oriented synthesis (DOS) and the "one bead-one stock solution" technology platform. Skeletal diversity, a difficult challenge in DOS, was achieved with a branching reaction pathway using one or two Diels-Alder reactions. This pathway yields small molecules having 10 different skeletons.
authors.affiliation: Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Ohyun
authors.initials: O
authors.lastname: Kwon
authors.forename: Seung Bum
authors.initials: SB
authors.lastname: Park
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D012996:Solutions; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D011083:Polycyclic Compounds; D012996:Solutions