[Conjugate vaccines].
Conjugate vaccines extend the vaccinal prevention for children to more diseases. Conjugating the capsular polysaccharide to a carrier protein transforms a T-independent antigen in a T-dependent, allowing protection of the children (before 2 years of age) against Haemophilus influenzae type b, meningococcal C and pneumococcal infections. This article reviews the 3 conjugate vaccines and their results with focus on some questions: antigens interference in the immunological response, serological subrogate for protection, herd immunity and replacement of circulating serotypes.
Swennen
B
B
Unité d'Epidémiologie pédiatrique et Vaccination, Ecole de Santé publique, U.L.B.
Sternon
J
J
D000328:Adult; D000917:Antibody Formation; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D006192:Haemophilus Infections / Q000517:prevention & control; D006193:Haemophilus influenzae; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008589:Meningococcal Infections / Q000517:prevention & control; D011008:Pneumococcal Infections / Q000517:prevention & control; D017778:Vaccines, Combined / Q000276:immunology*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D017778:Vaccines, Combined