title: Nephrotic syndrome and interstitial nephritis associated with celecoxib.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known to cause fluid and electrolyte abnormalities and renal failure. NSAIDs also may cause an acute allergic interstitial nephritis (AIN) and the nephrotic syndrome, characterized by histologic pathology consistent with minimal change disease in patients with previously normal renal function. The nephrotoxic potential of cyclooxygenase 2 (COX-2) inhibitors has not been established because AIN associated with nephrotic syndrome has not been reported secondary to the COX-2 inhibitors. This case report describes the first case of AIN associated with nephrotic syndrome in a patient treated with the selective COX-2 inhibitor, celecoxib.
authors.affiliation: Department of Medicine, Section of Nephrology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: Arnold B
authors.initials: AB
authors.lastname: Alper
authors.forename: Suzanne
authors.initials: S
authors.lastname: Meleg-Smith
authors.forename: N Kevin
authors.initials: NK
authors.lastname: Krane
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy / Q000201:enzymology; D000068579:Celecoxib; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology; D005920:Glomerular Mesangium / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007719:Knee Joint / Q000187:drug effects / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D008854:Microscopy, Electron; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000201:enzymology; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000201:enzymology; D011451:Prostaglandin-Endoperoxide Synthases; D011720:Pyrazoles; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D011720:Pyrazoles; D013449:Sulfonamides; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D000068579:Celecoxib