title: Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects.
abstract: This study attempted to replicate previous findings of decreased gray matter content in the subgenual prefrontal cortex (SGPFC) in mood disorder patients. Eighteen DSM-IV unipolar patients, 27 DSM-IV bipolar patients, and 38 healthy controls were studied. A 1.5T GE Signa Imaging System with Signa 5.4.3 software was used. The semi-automated software MedX (Sensor Systems, Sterling, VA) was utilized for the anatomical measures of SGPFC volumes. There were no significant differences in SGPFC volumes in familial and non-familial unipolar and bipolar patients compared with healthy controls, nor between drug-free and lithium-treated bipolar patients (ANOVA, p >.05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial.
authors.affiliation: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nicoletti
authors.forename: Keith
authors.initials: K
authors.lastname: Harenski
authors.forename: Roberto B
authors.initials: RB
authors.lastname: Sassi
authors.forename: Alan G
authors.initials: AG
authors.lastname: Mallinger
authors.forename: Ellen
authors.initials: E
authors.lastname: Frank
authors.forename: David J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000473:pathology*; D016009:Chi-Square Distribution; D003866:Depressive Disorder / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010361:Patients / Q000706:statistics & numerical data; D017397:Prefrontal Cortex / Q000002:abnormalities / Q000033:anatomy & histology / Q000473:pathology*; D018709:Statistics, Nonparametric