Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium.
This retrospective cohort study revealed that linezolid resistance in vancomycin-resistant Enterococcus faecium was dependent on prior linezolid exposure and duration of linezolid therapy. These strains of E. faecium were resistant to the entire class of oxazolidinones.
Pai
Manjunath P
MP
College of Pharmacy, University of New Mexico, Albuquerque, NM, USA.
Rodvold
Keith A
KA
Schreckenberger
Paul C
PC
Gonzales
Ronald D
RD
Petrolatti
Jennifer M
JM
Quinn
John P
JP
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016984:Enterococcus faecium; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D023303:Oxazolidinones / Q000494:pharmacology*; D012307:Risk Factors; D020713:Vancomycin Resistance / Q000502:physiology*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid