title: Components for integrated poly(dimethylsiloxane) microfluidic systems.
abstract: This review describes the design and fabrication of microfluidic systems in poly(dimethylsiloxane) (PDMS). PDMS is a soft polymer with attractive physical and chemical properties: elasticity, optical transparency, flexible surface chemistry, low permeability to water, and low electrical conductivity. Soft lithography makes fabrication of microfluidic systems in PDMS particularly easy. Integration of components, and interfacing of devices with the user, is also convenient and simpler in PDMS than in systems made in hard materials. Fabrication of both single and multilayer microfluidic systems is straightforward in PDMS. Several components are described in detail: a passive chaotic mixer, pneumatically actuated switches and valves, a magnetic filter, functional membranes, and optical components.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
authors.forename: Jessamine M K
authors.initials: JM
authors.lastname: Ng
authors.forename: Irina
authors.initials: I
authors.lastname: Gitlin
authors.forename: Abraham D
authors.initials: AD
authors.lastname: Stroock
authors.forename: George M
authors.initials: GM
authors.lastname: Whitesides
mesh_terms: D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004867:Equipment Design / Q000379:methods*; D005453:Fluorescence; D008280:Magnetics; D008567:Membranes, Artificial; D011327:Printing; D012828:Silicones / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D012828:Silicones; C013830:baysilon