title: Autologous fat injection to treat leakage around tracheoesophageal puncture.
abstract: OBJECTIVE
  To evaluate prospectively autologous fat injection as a treatment for leakage around tracheoesophageal puncture.
  
  
  METHODS
  For ten patients who exhibited leakage of saliva or liquid around their tracheoesophageal puncture, autologous fat injection was carried out into the tracheoesophageal wall around the maintained prosthesis. Short-term success was evaluated at one month, and long-term follow-up was continued as long as the patients remained alive. The effectiveness of the procedure was evaluated based on the presence or absence of leakage around the puncture as the patient swallowed methylene blue liquid. Patients were adjudged completely improved when no leakage of blue liquid was observed, partially improved when a slight stasis was evident, or unimproved when a marked leakage of blue liquid was noted.
  
  
  RESULTS
  Short-term success was achieved for 6 patients, 2 patients partially improved, and the procedure failed for 2 others. Long-term success (from 10 to 65 months) was achieved in all 4 of the completely improved patients who were free of disease, including 1 patient who required an additional injection. Removal of the puncture was later carried out in the 2 others for cervical node metastases or tracheal tumor. Definitive or transitional puncture closure or removal of the prosthesis was required in 3 partially or unimproved patients, whereas 1 partially improved patient died of lung metastasis 3 months later.
  
  
  CONCLUSIONS
  Fat injection around a voice prosthesis is a procedure that may be conducted as an alternative to other conservative techniques to decrease the size of the puncture. Close endoscopic observation is required however to eliminate secondary tumor that might expand the size of the puncture.
authors.affiliation: Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, Faculté de Médecine Saint Antoine, Université Paris VI, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Périé
authors.forename: Xie
authors.initials: X
authors.lastname: Ming
authors.forename: Eddy
authors.initials: E
authors.lastname: Dewolf
authors.forename: Jean Lacau
authors.initials: JL
authors.lastname: St Guily
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000368:Aged; D005260:Female; D006801:Humans; D007267:Injections; D007825:Laryngectomy / Q000534:rehabilitation; D007831:Larynx, Artificial / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011677:Punctures / Q000009:adverse effects*; D014182:Transplantation, Autologous; D016896:Treatment Outcome