Prevention of intraperitoneal adhesions by intraperitoneal lavage and intraperitoneal 5-fluorouracil: experimental studies.
Postoperative adhesions remain the leading cause of small bowel obstruction. Peritoneal adhesions were induced in 180 rats by scraping the cecum and burning the adjacent parietal peritoneum by electrocoagulation. The adhesions were scored 14 days later in a blinded manner. All four types of intraperitoneal instillations significantly reduced the extension and the severity of the adhesions, at both schedules, when compared to the control group. The use of 5-fluorouracil at 20 mg/kg in peritoneal dialysis solution during 5 days significantly decreased the global score (P = 0.04), the extension (P = 0.04), and the severity (P = 0.04) of adhesions when compared to the 5-day instillation of peritoneal dialysis alone. Lavage of the abdomen with peritoneal dialysis solution or hetastarch decreased the formation of adhesions. Instillation of 5-fluorouracil in a large volume of peritoneal dialysis solution could be novel and promising treatments for prevention of postoperative adhesions.
Pestieau
Sophie R
SR
The Washington Cancer Institute, Washington Hospital Center, District of Columbia 20010, USA.
Marchettini
Pierre
P
Stuart
O Anthony
OA
Chang
David
D
Sugarbaker
Paul H
PH
D000818:Animals; D015314:Dialysis Solutions / Q000627:therapeutic use; D004195:Disease Models, Animal; D005472:Fluorouracil / Q000627:therapeutic use*; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007322:Instillation, Drug; D008297:Male; D010952:Plasma Substitutes / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D007507:Therapeutic Irrigation; D000267:Tissue Adhesions / Q000517:prevention & control*
D015314:Dialysis Solutions; D006895:Hydroxyethyl Starch Derivatives; D007166:Immunosuppressive Agents; D010952:Plasma Substitutes; D005472:Fluorouracil