title: Novel endpoints and design of early clinical trials.
authors.affiliation: National Cancer Institute of Canada Clinical Trials Group, Queen's University, Kingston, Canada.
authors.forename: W R
authors.initials: WR
authors.lastname: Parulekar
authors.forename: E A
authors.initials: EA
authors.lastname: Eisenhauer
mesh_terms: D017321:Clinical Trials, Phase I as Topic / Q000592:standards* / Q000639:trends; D017322:Clinical Trials, Phase II as Topic / Q000592:standards* / Q000639:trends; D017326:Clinical Trials, Phase III as Topic / Q000592:standards* / Q000639:trends; D003627:Data Interpretation, Statistical; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D018579:Patient Selection; D015203:Reproducibility of Results; D012107:Research Design / Q000592:standards* / Q000639:trends; D018401:Sample Size; D012680:Sensitivity and Specificity