["Neoceader" contains nicotine. A report of two user's nicotine addiction].
"Neoceader smoking" is widely marketed in drug stores as an over the counter expectorant for cigarette smokers in Japan. Using high-pressure liquid chromatography, we determined that one piece of Neoceader (3 cm) contains 0.79 mg of nicotine, which is equivalent to one-sixth of the amount of nicotine in one Japanese cigarette (Mildseven extra-light, Mildseven super-light, or Sevenstar). Two patients who had switched from cigarette smoking to Neoceader smoking, subsequently became addicted to nicotine. The continine concentration in their urine were 937 ng/ml and 2,724 ng/ml, respectively. These findings demonstrate that Neoceader contains nicotine and that its use can lead to nicotine addiction.
Tanaka
Hideo
H
Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases.
Nogami
Hiroshi
H
Nakagawa
Hidekazu
H
Hasuo
Seiko
S
D000328:Adult; D005100:Expectorants / Q000032:analysis*; D006801:Humans; D008297:Male; D009538:Nicotine / Q000032:analysis*; D004366:Nonprescription Drugs; D013638:Tars; D014026:Nicotiana / Q000737:chemistry; D014029:Tobacco Use Disorder / Q000209:etiology
D005100:Expectorants; D004366:Nonprescription Drugs; D013638:Tars; C024746:tobacco tar; D009538:Nicotine