title: Position paper of the ESICM Working Group on Nutrition and Metabolism. Metabolic basis of nutrition in intensive care unit patients: ten critical questions.
abstract: The metabolic changes associated with critical illness involve several pathways acting at different steps of the utilization of nutritive substrates. The understanding of the role of these pathways and of their complex regulation has led to the development of new strategies for the metabolic and nutritional management of critically ill patients, including the development of new products for nutritional support. The rationale for changing the profile of nutritional support solutions by adding novel substrates is also discussed. This review focuses on the metabolic specificities of critically ill patients and also includes an analysis of the adequacy of tools to monitor the metabolic status and the adequacy of the nutritional support.
authors.affiliation: Istituto di Clinico Medica, University of Trieste, Ospedale di Cattinara, 34100 Trieste, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Biolo
authors.forename: George
authors.initials: G
authors.lastname: Grimble
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Preiser
authors.forename: Xavier
authors.initials: X
authors.lastname: Leverve
authors.forename: Philippe
authors.initials: P
authors.lastname: Jolliet
authors.forename: Mercedes
authors.initials: M
authors.lastname: Planas
authors.forename: Erich
authors.initials: E
authors.lastname: Roth
authors.forename: Jan
authors.initials: J
authors.lastname: Wernerman
authors.forename: Claude
authors.initials: C
authors.lastname: Pichard
mesh_terms: D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D004734:Energy Metabolism; D006801:Humans; D008659:Metabolic Diseases / Q000178:diet therapy* / Q000503:physiopathology*; D018529:Nutritional Support / Q000379:methods*; D013312:Stress, Physiological / Q000378:metabolism