title: One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT.
abstract: A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.
authors.affiliation: Key Laboratory of Bio-organic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Xiao Bin
authors.initials: XB
authors.lastname: Sun
authors.forename: Jian Xun
authors.initials: JX
authors.lastname: Kang
authors.forename: Yu Fen
authors.initials: YF
authors.lastname: Zhao
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis; D006801:Humans; D063065:Organophosphonates / Q000138:chemical synthesis; D011355:Prodrugs / Q000138:chemical synthesis*; D018119:Stavudine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis*
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D011355:Prodrugs; D015215:Zidovudine; D018119:Stavudine