Neuropeptide Y and its receptors as potential therapeutic drug targets.
Neuropeptide Y (NPY) is a 36-amino-acid peptide that exhibits a large number of physiological activities in the central and peripheral nervous systems. NPY mediates its effects through the activation of six G-protein-coupled receptor subtypes named Y(1), Y(2), Y(3), Y(4), Y(5), and y(6). Evidence suggests that NPY is involved in the pathophysiology of several disorders, such as the control of food intake, metabolic disorders, anxiety, seizures, memory, circadian rhythm, drug addiction, pain, cardiovascular diseases, rhinitis, and endothelial cell dysfunctions. The synthesis of agonists and antagonists for these receptors could be useful to treat several of these diseases.
Silva
Antonio P
AP
Division of Hypertension and Vascular Medicine, Centre Hospitalier Universitaire Vaudois, Av. Pierre Decker, 1011 Lausanne, Switzerland.
Cavadas
Claudia
C
Grouzmann
Eric
E
D000818:Animals; D006801:Humans; D009478:Neuropeptide Y / Q000494:pharmacology* / Q000502:physiology; D017476:Receptors, Neuropeptide Y / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000145:classification / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y