Peptidergic mechanisms of hyperthermia-evoked convulsions in rats in early postnatal ontogenesis.
This report addresses the verification of the hypothesis that arginine-vasopressin affects the formation of hyperthermia-evoked convulsions in early ontogenesis in rats on days 3, 5, 7, and 9 of postnatal life. The modification of experimental febrile convulsions by PACAP (pituitary adenylate cyclase-activating peptide) was investigated; PACAP is a physiological regulator of the neurosecretion of arginine-vasopressin. Arginine-vasopressin (10 microg/rat) and PACAP (0.01 microg/rat) decreased the latency of generalized tonic-clonic convulsions and the time of truncal generalization of convulsive activity on days 3 and 5 of rat development. Animals given arginine-vasopressin (0.1-10 microg/rat) sowed significant increases in the duration of generalized convulsions to the level of status epilepticus on day 9 of life. Conversely, administration of higher doses of PACAP (0.1 microg/rat) increased the threshold of tonic-clonic convulsions on days 3 and 5 and decreased it on days 7 and 9 of postnatal development. The indirect involvement of PACAP in the mechanisms of experimental febrile convulsions is suggested to act via changes in arginine-vasopressin neurosecretion.
Chepurnova
N E
NE
Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Russia.
Ponomarenko
A A
AA
Chepurnov
S A
SA
D000818:Animals; D000831:Animals, Newborn; D001127:Arginine Vasopressin / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology; D009479:Neuropeptides / Q000627:therapeutic use*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011181:Postnatal Care; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D003294:Seizures, Febrile / Q000188:drug therapy*; D013997:Time Factors
C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D001127:Arginine Vasopressin