Lamins: building blocks or regulators of gene expression?
Intermediate filament (IF) proteins are the building blocks of cytoskeletal filaments, the main function of which is to maintain cell shape and integrity. The lamins are thought to be the evolutionary progenitors of IF proteins and they have profound influences on both nuclear structure and function. These influences require the lamins to have dynamic properties and dual identities--as building blocks and transcriptional regulators. Which one of these identities underlies a myriad of genetic diseases is a topic of intense debate.
Hutchison
Christopher J
CJ
Department of Biological and Biomedical Sciences, University of Durham, South Road, Durham DH1 3LE, UK. c.j.hutchison@durham.ac.uk
D000818:Animals; D005075:Biological Evolution; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology; D002467:Cell Nucleus / Q000502:physiology; D002607:Charcot-Marie-Tooth Disease / Q000503:physiopathology; D004261:DNA Replication / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D034882:Lamins / Q000235:genetics / Q000502:physiology*; D008060:Lipodystrophy / Q000503:physiopathology; D020389:Muscular Dystrophy, Emery-Dreifuss / Q000235:genetics / Q000503:physiopathology; D009685:Nuclear Envelope / Q000502:physiology; D034881:Nuclear Lamina / Q000502:physiology; D022022:Nuclear Pore / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D034882:Lamins