[Pulse pressure and coronary disease].
The concept of pulse pressure has been developed over the past 10 years. Large observational studies in the general population have shown a link between pulse pressure and risk of late coronary events. The correlation between pulse pressure and coronary events appears particularly strong in the elderly. More limited data have shown that a high level of pulse pressure was related to angiographically documented coronary artery disease; recently, a correlation between pulse pressure and a high level of C reactive protein has been evidenced in the NHANES cohort. In patients with known coronary artery disease, pulse pressure is a prognostic factor, both after myocardial infarction with left ventricular dysfunction (SAVE trial) and after myocardial revascularization by coronary surgery or angioplasty (BARI randomised trial and registry). In addition, two small-sized studies have shown a strong correlation between pulse pressure and restenosis after conventional percutaneous transluminal coronary angioplasty.
Danchin
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Service de cardiologie, hôpital européen Georges-Pompidou, 20 rue Leblanc, 75015 Paris. Nicolas.danchin@egp.ap-hop-paris.fr
D001794:Blood Pressure / Q000502:physiology*; D003327:Coronary Disease / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000453:epidemiology; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors