Synthesis and biological evaluation of new mannose 6-phosphate analogues.
Three new analogues of mannose 6-phosphate (M6P)--a sulphate and two carboxylates--have been synthesized and their affinity toward the M6P/IGFII receptor evaluated by affinity column chromatography. These compounds display strong binding to the receptor and therefore are new M6P analogues which may find some dermatological applications, for example healing of post-surgical scars.
Vidal
Sébastien
S
Laboratoire de Chimie Biomoléculaire (UMR 5032), Université Montpellier II, Ecole Nationale Supérieure de Chimie de Montpellier, France.
Garcia
Marcel
M
Montero
Jean-Louis
JL
Morère
Alain
A
D002847:Chromatography, Agarose; D016503:Drug Delivery Systems; D008247:Lysosomes; D008360:Mannosephosphates / Q000138:chemical synthesis* / Q000378:metabolism*; D011485:Protein Binding; D017527:Receptor, IGF Type 2 / Q000378:metabolism*; D013329:Structure-Activity Relationship
D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; C027693:mannose-6-phosphate