title: Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors.
abstract: The chiral separation of cyclic Mannich ketones of potential pharmaceutical interest is investigated using HPLC and CE. These Mannich ketones show a marked antibacterial and antifungal activity. In HPLC, stationary phases containing cellulose derivatives or beta-cyclodextrin were used and in CE different cyclodextrins, such as beta-CD, gamma-CD, carboxymethyl-beta-CD and succinyl-beta-CD were added to the background electrolyte as chiral selectors.
authors.affiliation: Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Universitätsplatz 1, A-8010 Graz, Austria.
authors.forename: Nina
authors.initials: N
authors.lastname: Grobuschek
authors.forename: Lawan
authors.initials: L
authors.lastname: Sriphong
authors.forename: Martin G
authors.initials: MG
authors.lastname: Schmid
authors.forename: Tamàs
authors.initials: T
authors.lastname: Lorànd
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
authors.forename: Gerald
authors.initials: G
authors.lastname: Gübitz
mesh_terms: D001681:Biological Assay / Q000295:instrumentation / Q000379:methods; D002482:Cellulose / Q000031:analogs & derivatives*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D008352:Mannich Bases / Q000737:chemistry / Q000302:isolation & purification*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D008352:Mannich Bases; D002482:Cellulose