Mania following deep brain stimulation for Parkinson's disease.
Three patients with PD developed manic behavior after bilateral implantation of electrodes for deep-brain stimulation (DBS). Common to all three patients were manic symptoms unremitting after levodopa reduction or stimulation "off," lower electrodes positioning caudal to the subthalamic nucleus area, postoperative DBS with the lower contacts (0) of the quadripolar electrodes, and resolution of the manic episodes coinciding with stimulation through higher contacts.
Kulisevsky
J
J
Movement Disorders Unit, Department of Neurology, Functional Neurosurgery Program for Movement Disorders, Sant Pau Hospital, Autonomous University of Barcelona, Spain. jkulisevsky@hsp.santpau.es
Berthier
M L
ML
Gironell
A
A
Pascual-Sedano
B
B
Molet
J
J
Parés
P
P
D000328:Adult; D000978:Antiparkinson Agents / Q000008:administration & dosage; D001714:Bipolar Disorder / Q000209:etiology*; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D004567:Electrodes, Implanted; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000628:therapy*
D000978:Antiparkinson Agents; D007980:Levodopa