title: [Optimization of radiotherapy planning for non-small cell lung cancer (NSCLC) using 18FDG-PET].
abstract: OBJECTIVE
  In recent years, FDG-PET examinations have become more important for problems in oncology, especially in staging of bronchogenic carcinoma. In the retrospective study presented here, the influence of PET on the planning of radiotherapy for patients with non-small-cell lung cancer (NSCLC) was investigated.
  
  
  METHODS
  The study involved 39 patients with NSCLC who had been examined by PET for staging. They received radiotherapy on the basis of the anterior/posterior portals including the primary tumour and the mediastinum planned according to CT- and bronchoscopic findings. The results of the PET examination were not considered in initial radiotherapy planning. The portals were retrospectively redefined on the basis of FDG uptake considering the size and localization of the primary tumour; and FDG activities outside the mediastinal part of the portals.
  
  
  RESULTS
  In 15 out of 39 patients, the CT/PET-planned portals differed from the CT-planned ones. In most causes (n = 12) the CT/PET field was smaller than the CT field. The median geometric field size of the portals was 179 cm2, after redefinition using PET 166 cm2. In 20 patients with disturbed ventilation caused by the tumour (atelectasis, dystelectosis), a correction of the portal was suggested significantly more frequently than in the other patients (p = 0.03).
  
  
  CONCLUSIONS
  Our results demonstrate the synergism of topographical (CT) and metabolic (FDG-PET) information, which could be helpful in planning radiotherapy of bronchial carcinoma, especially for patients with disturbed ventilation.
authors.affiliation: Abteilung für Nuklearmedizin, Universitätskliniken des Saarlandes, Homburg/Saar.
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: U
authors.initials: U
authors.lastname: Nestle
authors.forename: K
authors.initials: K
authors.lastname: Walter
authors.forename: N
authors.initials: N
authors.lastname: Licht
authors.forename: D
authors.initials: D
authors.lastname: Ukena
authors.forename: K
authors.initials: K
authors.lastname: Schnabel
authors.forename: C M
authors.initials: CM
authors.lastname: Kirsch
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D019275:Radiopharmaceuticals; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18