Bone growth oscillation: longitudinal metabolic process of bone growth in congenital adrenal hyperplasia and nonendocrine short stature.
To clarify the longitudinal metabolic process of bone growth in children, we observed the relationship between the level of serum osteocalcin (OC), a marker of bone metabolism, and growth velocity in 10 prepubertal patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency and 9 prepubertal patients with nonendocrine short stature (NESS), but no major hormonal abnormalities influencing bone metabolism. Observations were made every 6 months over a 7-year period. In patients with CAH who exhibited a wide variation in growth velocity during the course of the investigation, the levels of OC fluctuated over a wide range, suggesting metabolically variable bone growth. In contrast, in patients with NESS who exhibited a relatively stable growth velocity, the OC level remained within a narrow range, suggesting metabolically stable bone growth. The meaning of such divergent metabolic processes of bone growth observed in CAH and NESS and its relationship to actual bone structure or bone intensity should be further investigated.
Arisaka
O
O
Department of Pediatrics, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
Kanno
H
H
Negishi
M
M
Kojima
M
M
Nishikura
K
K
Numata
M
M
Kanazawa
S
S
Nitta
A
A
Kuribayashi
T
T
Kano
K
K
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000201:enzymology / Q000503:physiopathology*; D001846:Bone Development; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood; D011446:Prospective Studies; D013255:Steroid 21-Hydroxylase / Q000378:metabolism
D015675:Osteocalcin; D013255:Steroid 21-Hydroxylase