title: Endovascular abdominal aortic aneurysm repair with general versus local anesthesia: a comparison of cardiopulmonary morbidity and mortality rates.
abstract: OBJECTIVE
  The purpose of this study was to compare the cardiopulmonary morbidity and mortality rates after endovascular abdominal aortic aneurysm (EAAA) repair with local anesthesia (LA) with intravenous sedation versus general anesthesia (GA).
  
  
  METHODS
  Data from patients who underwent elective infrarenal EAAA repair between June 1996 and October 2000 were retrospectively reviewed. Patients with two or more Eagle clinical cardiac risk factors were considered to be at increased risk for a major postoperative cardiac event. Univariate and multivariate analyses for major cardiac and pulmonary morbidity and mortality rates were analyzed with respect to anesthetic type (GA versus LA), age, size of aneurysm, mean number of Eagle risk factors, and presence of two or more cardiac risk factors.
  
  
  RESULTS
  Two hundred twenty-nine patients underwent EAAA repair. The GA (158 patients) and LA (71 patients) groups were significantly different with respect to mean age (73 versus 76 years; P =.01) and mean number of cardiac risk factors per patient (1.2 versus 1.6; P =.002). No difference was seen in the overall cardiopulmonary complication rate (13% for GA and 19% for LA; P =.3), pulmonary complication rate (3.8% for GA and 7% for LA; P =.3), or cardiopulmonary mortality rate (3.2% for GA and 2.8% for LA; P =.9). The major cardiac event rate was higher in patients with two or more Eagle risk factors (22%) versus those patients with one or less Eagle risk factors (3.4%; P <.001), irrespective of anesthetic type. In analysis of patients with one or less Eagle risk factors, no difference was seen in the major cardiac event rate by anesthetic type (3% for GA and 5% for LA; P =.6). Also, no difference was seen in major cardiac events in patients with two or more Eagle risk factors by anesthetic type (24% for GA and 22% for LA). On multivariate analysis, the mean number of Eagle risk factors per patient (P <.0001) and the presence of two or more Eagle risk factors were associated with major cardiac and cardiopulmonary complications, whereas age, size of AAA, and anesthetic type were not.
  
  
  CONCLUSIONS
  No difference exists in overall cardiac and pulmonary morbidity and mortality rates after EAAA repair in comparison of GA and LA. The presence of two or more preoperative cardiac risk factors significantly increases the risk of a major postoperative cardiac event.
authors.affiliation: Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA 90509, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: De Virgilio
authors.forename: Lina
authors.initials: L
authors.lastname: Romero
authors.forename: Carlos
authors.initials: C
authors.lastname: Donayre
authors.forename: Kelly
authors.initials: K
authors.lastname: Meek
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Lewis
authors.forename: Maurice
authors.initials: M
authors.lastname: Lippmann
authors.forename: Christian
authors.initials: C
authors.lastname: Rodriguez
authors.forename: Rodney
authors.initials: R
authors.lastname: White
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D000772:Anesthesia, Local; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D006331:Heart Diseases / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology* / Q000401:mortality; D009017:Morbidity; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D012307:Risk Factors; D015996:Survival Rate