title: [The hyperplasia-adenoma sequence: a case supporting this hypothesis].
abstract: We described the morphological, histochemical and immunohistochemical findings of a polyp detected in the left colon (splenic flexure) in which the diagnosis was atypical hyperplastic polyp. The description is focused on the capability of a hyperplastic polyp to evolve into adenomatous tissue through different modalities.
authors.affiliation: 2o Servizio di Anatomia ed Istologia Patologica, Università degli Studi di Brescia, Spedali Civili di Brescia, P.le Spedali Civili 1 I-25100 Brescia, Italia. villan@iol.it
authors.forename: V
authors.initials: V
authors.lastname: Villanacci
authors.forename: C
authors.initials: C
authors.lastname: Zambelli
authors.forename: A
authors.initials: A
authors.lastname: Santoro
authors.forename: R
authors.initials: R
authors.lastname: Nascimbeni
authors.forename: M
authors.initials: M
authors.lastname: Ghirardi
authors.forename: B
authors.initials: B
authors.lastname: Salerni
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D003106:Colon / Q000378:metabolism / Q000473:pathology*; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology*; D003111:Colonic Polyps / Q000737:chemistry / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D006965:Hyperplasia; D007381:Intermediate Filament Proteins / Q000032:analysis; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D053554:Keratin-20; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; D053554:Keratin-20; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53