The Tol proteins of Escherichia coli and their involvement in the translocation of group A colicins.
The Tol proteins are involved in outer membrane stability of Gram-negative bacteria. The TolQRA proteins form a complex in the inner membrane while TolB and Pal interact near the outer membrane. These two complexes are transiently connected by an energy-dependent interaction between Pal and TolA. The Tol proteins have been parasitized by group A colicins for their translocation through the cell envelope. Recent advances in the structure and energetics of the Tol system, as well as the interactions between the N-terminal translocation domain of colicins and the Tol proteins are presented.
Lazzaroni
Jean-Claude
JC
Unité de Microbiologie et Génétique, UMR5122 CNRS-INSA, Université Lyon-1, bâtiment André-Lwoff, 10, rue Dubois, 69622 Villeurbanne cedex, France. lazaroni@biomserv.univ-lyon.fr
Dubuisson
Jean-François
JF
Vianney
Anne
A
D003087:Colicins / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology
D003087:Colicins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; C062093:tolA protein, E coli; C060792:tolQ protein, E coli; C060794:tolR protein, E coli