[beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers].
This study was designed to evaluate, in healthy volunteers, differences of bronchodilator responsiveness to a beta 2-agonist between those with the Arg 16/Gly 16 allele and those with the Gly 16/Gly 16 allele at codon 16 of beta 2 adrenoceptor polymorphism. Peak flow and pulmonary functions were measured by body plethysmography after the inhalation of procaterol. In the Arg 16/Gly 16 group, the resulting acute increase of V 25 and acute decrease of airway resistance were greater, and the bronchodilator effect of a single inhaled beta 2-agonist was longer, than those observed in the Gly 16/Gly 16 group. The present study showed that a single inhalation of procaterol has a varying bronchodilator effect on healthy adults, depending on the genotype of beta 2 adrenoceptor polymorphism at codon 16.
Kobayashi
Makoto
M
3rd Department of Internal Medicine, Kochi Medical School, Okou-cho, Nankoku, Kochi 783-8505, Japan.
Kishimoto
Nobuhito
N
Ohnishi
Hisako
H
Tada
Shinya
S
Ueda
Nobuo
N
Kamei
Tadashi
T
Fujita
Jiro
J
Taguchi
Hirokuni
H
D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D010993:Plethysmography, Whole Body; D011110:Polymorphism, Genetic; D017265:Procaterol / Q000008:administration & dosage / Q000494:pharmacology*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D018343:Receptors, Adrenergic, beta-2; D017265:Procaterol