Interaction of non-alcoholic fatty liver disease with other liver diseases.
Obesity-related steatosis is an increasingly common histological finding in liver biopsies and may co-exist with other chronic liver diseases. Although non-alcoholic fatty liver disease (NAFLD) without true steatohepatitis is generally a benign condition, when another liver disease is present, steatosis may exacerbate the liver damage. In this review, we discuss the interaction of obesity-related steatosis with chronic hepatitis C, alcoholic liver disease, disorders of hepatic iron storage and drug-induced liver disease. The role of weight reduction in minimizing liver injury in patients with chronic hepatitis C is discussed. Finally, we discuss the problems associated with orthotopic liver transplantation for patients with NAFLD.
Clouston
Andrew D
AD
The University of Queensland and Sullivan Nicolaides Pathology, Brisbane, Australia.
Powell
Elizabeth E
EE
D015992:Body Mass Index; D056486:Chemical and Drug Induced Liver Injury; D018450:Disease Progression; D005234:Fatty Liver / Q000209:etiology*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000235:genetics; D006519:Hepatitis, Alcoholic / Q000150:complications*; D006801:Humans; D007501:Iron / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism*; D016031:Liver Transplantation; D009765:Obesity / Q000150:complications*; D012307:Risk Factors
D007501:Iron