title: Genetic regulation of host responses to Salmonella infection in mice.
abstract: Salmonella spp are Gram-negative bacteria capable of infecting a wide range of host species, including humans, domesticated and wild mammals, reptiles, birds and insects. The outcome of an encounter between Salmonella and its host is dependent upon multiple factors including the host genetic background. To facilitate the study of the genetic factors involved in resistance to this pathogen, mouse models of Salmonella infection have been developed and studied for years, allowing identification of several genes and pathways that may influence the disease outcome. In this review, we will cover some of the genes involved in mouse resistance to Salmonella that were identified through the study of congenic mouse strains, cloning of spontaneous mouse mutations, use of site-directed mutagenesis or quantitative trait loci analysis. In parallel, the relevant information pertaining to genes involved in resistance to Salmonella in humans will be discussed.
authors.affiliation: Department of Human Genetics, McGill University Health Center, Montréal, Québec, Canada.
authors.forename: M-F
authors.initials: MF
authors.lastname: Roy
authors.forename: D
authors.initials: D
authors.lastname: Malo
mesh_terms: D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism; D003001:Cloning, Molecular; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D005786:Gene Expression Regulation / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics* / Q000502:physiology; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000276:immunology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D020297:Mice, Congenic / Q000276:immunology; D019255:NADPH Oxidases / Q000235:genetics / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D040641:Quantitative Trait Loci / Q000276:immunology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D012481:Salmonella Infections, Animal / Q000235:genetics* / Q000276:immunology*; D051193:Toll-Like Receptors; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D000077329:Agammaglobulinaemia Tyrosine Kinase; D027682:Cation Transport Proteins; D016207:Cytokines; D029721:Drosophila Proteins; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D019255:NADPH Oxidases; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D011505:Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D000099173:Natural Resistance-associated Macrophage Protein 1; C496317:Nos2 protein, mouse