Correlation of biochemical parameters with single parathyroid adenoma weight and volume.
OBJECTIVE
To determine the relationship of the biochemical parameters serum phosphate, serum calcium, and serum parathyroid hormone levels with respect to parathyroid adenoma weight and volume in primary hyperparathyroidism.


METHODS
Retrospective review of 63 cases of primary hyperparathyroidism from 1992 to 1998.


METHODS
Single parathyroid adenomas were identified from surgical pathology reports. Preoperative calcium, phosphate, and parathyroid hormone levels were collected from charts. The volume of the adenoma was calculated using a mathematical equation for the volume of an ellipsoid object. The data were analyzed using a multiple analysis of variance, and a correlation coefficient was calculated. The level of significance was set at p < or = .05.


RESULTS
With respect to adenoma volume, there was a significant correlation with serum calcium and parathormone levels (p = .0001 and p = .0001, respectively). There was no significant correlation between serum phosphate and adenoma volume. With respect to adenoma weight, there was a significant correlation with serum calcium and parathormone levels (p = .0001 and p = .0001, respectively). There was no significant correlation between serum phosphate and adenoma weight.


CONCLUSIONS
Preoperative serum calcium and parathormone levels may be able to predict adenoma weight and volume in primary hyperparathyroidism for a single adenoma.
Bindlish
Vinita
V
Department of Otolaryngology, Mount Sinai Hospital, University of Toronto, 401-600 University Avenue, Toronto, Ontario, Canada, M5G 1X5.
Freeman
Jeremy L
JL
Witterick
Ian J
IJ
Asa
Sylvia L
SL
D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D000704:Analysis of Variance; D002118:Calcium / Q000097:blood; D006801:Humans; D008433:Mathematics; D009929:Organ Size; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000378:metabolism / Q000473:pathology*; D010710:Phosphates / Q000097:blood; D012189:Retrospective Studies
D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium