Synthesis of alpha-amino acid derivatives and amines via activation of simple alkyl halides by zinc in water.
A method for the synthesis of alpha-amino acid derivatives and amines is developed via a zinc-mediated conjugate addition reaction of alkyl halides to alpha-phthalimidoacrylate derivatives and nucleophilic addition to imines in the presence of NH4Cl in water. No reaction was observed in the absence of water.
Huang
Taisheng
T
Department of Chemistry, Tulane University, New Orleans, LA, USA.
Keh
Charlene C K
CC
Li
Chao-Jun
CJ
D000588:Amines / Q000138:chemical synthesis*; D000596:Amino Acids / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D012996:Solutions; D015032:Zinc / Q000737:chemistry
D000588:Amines; D000596:Amino Acids; D006846:Hydrocarbons, Halogenated; D012996:Solutions; D015032:Zinc