title: Humanization of monoclonal antibodies by CDR grafting.
authors.affiliation: AERES Biomedical Ltd., London, UK.
authors.forename: Siobhan
authors.initials: S
authors.lastname: O'Brien
authors.forename: Tarran
authors.initials: T
authors.lastname: Jones
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D015703:Antigens, CD / Q000276:immunology; D001667:Binding, Competitive; D019556:COS Cells / Q000502:physiology; D003001:Cloning, Molecular; D022801:Complementarity Determining Regions / Q000235:genetics / Q000276:immunology*; D018274:Electroporation; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000096:biosynthesis / Q000302:isolation & purification; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry / Q000235:genetics*; D007147:Immunoglobulin Light Chains / Q000737:chemistry / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D014162:Transfection
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D022801:Complementarity Determining Regions; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains