title: Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated.
abstract: Intestinal perforation, a life-threatening complication of toxic megacolon (TM) following non-typhoid Salmonella infection, is relatively uncommon in infants less than 1 year of age. The situation, also found in typhoid fever, appears to be cytokine-mediated. This finding may justify immunotherapy for older children with TM associated with non-typhoid Salmonella infection in order to prevent this complication.
authors.affiliation: Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan, ROC.
authors.forename: C-H
authors.initials: CH
authors.lastname: Chiu
authors.forename: L-H
authors.initials: LH
authors.lastname: Su
authors.forename: C-C
authors.initials: CC
authors.lastname: He
authors.forename: T-H
authors.initials: TH
authors.lastname: Jaing
authors.forename: C-C
authors.initials: CC
authors.lastname: Luo
authors.forename: T-Y
authors.initials: TY
authors.lastname: Lin
mesh_terms: D000367:Age Factors; D002675:Child, Preschool; D004760:Enterocolitis / Q000150:complications* / Q000382:microbiology; D006801:Humans; D007223:Infant; D007416:Intestinal Perforation / Q000209:etiology* / Q000276:immunology; D008532:Megacolon, Toxic / Q000150:complications*; D012480:Salmonella Infections / Q000150:complications*