title: [High frequency of precancerous lesions of gastric cancer associated with Helicobacter pylori and response to treatment, in Chiapas, Mexico].
abstract: Stomach cancer is the second cause of death in Mexico in patients with malignant tumors. This disease represents a public health problem. A strong association has been described between chronic infection with Helicobacter pylori and gastric cancer. This malignancy is preceded by a series of preneoplastic conditions, including chronic atrophic gastritis (CAG), intestinal metaplasia (IM), and dysplasia. The objective of this study was to establish the prevalence of preneoplastic conditions associated with infection of Helicobacter pylori in the state of Chiapas and its eradication with antibiotics. Persons infected with Helicobacter pylori and with CAG were identified by serology against CagA protein and serologic levels of gastrin. An endoscopy with biopsy was performed at the beginning of the study, and at 6 weeks and 1 year thereafter. A total of 281 people were enrolled and randomly assigned to treatment or placebo group. CAG was found in 59%, IM in 51%, and dysplasia in 13%. In intent-to-treat and per-protocol analysis, Helicobacter pylori was eliminated in 70 and 76%, respectively. These results indicate high frequency of preneoplastic conditions associated with Helicobacter pylori and an excellent eradication rate. They also offer a possible alternative for preventing gastric cancer.
authors.affiliation: Instituto Nacional de Cancerología, Ave. San Fernando #22, Tlalpan 14000, México, D.F. mohar@conacyt.mx
authors.forename: Alejandro
authors.initials: A
authors.lastname: Mohar
authors.forename: Catherine
authors.initials: C
authors.lastname: Ley
authors.forename: Jeannette
authors.initials: J
authors.lastname: Guarner
authors.forename: Roberto
authors.initials: R
authors.lastname: Herrera-Goepfert
authors.forename: Luz
authors.initials: L
authors.lastname: Sánchez
authors.forename: David
authors.initials: D
authors.lastname: Halperin
authors.forename: Julie
authors.initials: J
authors.lastname: Parsonnet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology*; D015995:Prevalence; D013274:Stomach Neoplasms / Q000382:microbiology*