title: New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae.
abstract: Wood from three different plants of the Celastraceae growing in their natural habitats in Brazil (Maytenus aquifolia Mart.) and South Africa [Putterlickia retrospinosa van Wyk and Mostert, P. verrucosa (E. Meyer ex Sonder) Szyszyl.] was established as a source of endophytic bacteria using a medium selective for actinomycetes. Two isolates were identified as Streptomyces setonii and S. sampsonii whereas two others were not assignable to any of the known Streptomyces species. They were preliminarily named Streptomyces Q21 and Streptomyces MaB-QuH-8. The latter strain produces a new chloropyrrol and chlorinated anthracyclinone. The chloropyrrol showed high activity against a series of multiresistent bacteria and mycobacteria.
authors.affiliation: Institut für Pharmazeutische Biologie der Universität Bonn, Nussallee 6, 53115 Bonn, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Pullen
authors.forename: Petra
authors.initials: P
authors.lastname: Schmitz
authors.forename: Kristina
authors.initials: K
authors.lastname: Meurer
authors.forename: Daniel D v
authors.initials: DD
authors.lastname: Bamberg
authors.forename: Stephanie
authors.initials: S
authors.lastname: Lohmann
authors.forename: Suzelei
authors.initials: S
authors.lastname: De Castro França
authors.forename: Ingrid
authors.initials: I
authors.lastname: Groth
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlegel
authors.forename: Ute
authors.initials: U
authors.lastname: Möllmann
authors.forename: Friedrich
authors.initials: F
authors.lastname: Gollmick
authors.forename: Udo
authors.initials: U
authors.lastname: Gräfe
authors.forename: Eckhard
authors.initials: E
authors.lastname: Leistner
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029753:Celastraceae / Q000378:metabolism / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D029755:Maytenus / Q000378:metabolism / Q000382:microbiology; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D001685:Biological Factors; D009285:Naphthoquinones; D011758:Pyrroles; D012118:Resorcinols; C472377:celastramycin A; C472378:celastramycin B