Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma.
Paracoccidioidomycosis is an endemic fungal infection in Latin America. This mucocutaneous disease often involves the oral mucosa and may clinically resemble other infectious and neoplastic processes. Paracoccidioidomycosis that clinically suggested squamous cell carcinoma was diagnosed in 2 patients with a history of heavy alcohol and tobacco use. Antifungal therapy with ketoconazole and itraconazole resulted in resolution of the oral lesions. Interestingly, 1 patient had a pulmonary lesion that persisted after antifungal therapy, and biopsy proved this to be a squamous cell carcinoma of the lung.
Meneses-García
Abelardo
A
Departmento de Patología, Instituto Nacional de Cancerología, Mexico City, Mexico.
Mosqueda-Taylor
Adalberto
A
Morales-de la Luz
Rosario
R
Rivera
Luz María Ruíz-Godoy
LM
D000935:Antifungal Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D002908:Chronic Disease; D003937:Diagnosis, Differential; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007654:Ketoconazole / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D010229:Paracoccidioidomycosis / Q000188:drug therapy / Q000473:pathology*
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole