title: A new method for evaluation of safety of antiarrhythmic drugs.
abstract: A new method for preclinical evaluation of safety of antiarrhythmic drugs is proposed. During chronic stress, class I antiarrhythmic preparations increased mortality of test animals. By contrast, class II-IV antiarrhythmic agents and antioxidants produced no significant effect on mortality of experimental mice. These data agree with published results of multicenter studies.
authors.affiliation: Department of Biology, Mordvinian State University. slava@mrsu.ru
authors.forename: V P
authors.initials: VP
authors.lastname: Balashov
authors.forename: L A
authors.initials: LA
authors.lastname: Balykova
authors.forename: E N
authors.initials: EN
authors.lastname: Shuvalova
authors.forename: T I
authors.initials: TI
authors.lastname: Shevorakova
authors.forename: V N
authors.initials: VN
authors.lastname: Poderov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D002986:Clinical Trials as Topic / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D051379:Mice; D015337:Multicenter Studies as Topic; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D000975:Antioxidants