title: Multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma: a rare simultaneous occurrence.
abstract: A rare simultaneous occurrence of multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma was diagnosed in a 70-year-old man who presented with fever, polyarthralgia, weight loss, vascular purpura, anemia, generalized lymphadenopathy, and hepatosplenomegaly. He had no risk of HIV infection and serological tests for HIV were negative twice, but a low number of T-cells and a reversed CD4/CD8 ratio were observed. During hospitalization, he developed Kaposi's sarcoma at the right sole. Lymph node biopsies revealed multicentric Castleman's disease together with a large B-cell lymphoma, which showed monotypic IgM-lambda lymphocytes. To our knowledge, this is the first report in which systemic manifestations of all three diseases occurred simultaneously prior to any specific treatment. The altered immune status and human herpesvirus-8 infection might have played a role in the pathogenesis of this occurrence.
authors.affiliation: Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Sanya
authors.initials: S
authors.lastname: Sukpanichnant
authors.forename: Apichati
authors.initials: A
authors.lastname: Sivayathorn
authors.forename: Sukon
authors.initials: S
authors.lastname: Visudhiphan
authors.forename: Weerapan
authors.initials: W
authors.lastname: Ngowthammatas
mesh_terms: D000368:Aged; D001706:Biopsy; D005871:Castleman Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology