title: Humoral immune response against Borna disease virus (BDV) in experimentally and naturally infected cats.
abstract: In order to investigate the peripheral and intracerebral humoral immune response against Borna disease virus (BDV) in cats, serum and cerebrospinal fluid (CSF) samples from experimentally and naturally BDV-infected cats were analysed in two different test systems (indirect enzyme-linked immunosorbent assay and indirect immunofluorescent test). The experimentally infected cats developed high antibody titres against the major immunogenic BDV-proteins, p24 and p40. In contrast, the naturally infected cats showed a comparatively weak humoral immune response. The experimentally infected cats were inoculated with either BDV laboratory strain V or a feline BDV-isolate. Some differences existed between the two groups of cats. The former group developed a higher response against p40, whereas the latter group showed, beside the p40-response, a more pronounced p24-response, similar to the situation in the naturally infected cats.
authors.affiliation: Department of Pathology, Swedish University of Agricultural Sciences (SUAS), 750 07, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Johansson
authors.forename: M
authors.initials: M
authors.lastname: Berg
authors.forename: A-L
authors.initials: AL
authors.lastname: Berg
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D000956:Antigens, Viral / Q000276:immunology; D001890:Borna Disease / Q000276:immunology*; D001891:Borna disease virus / Q000276:immunology*; D002371:Cat Diseases / Q000276:immunology* / Q000821:virology*; D002415:Cats; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D008297:Male
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral