title: The value of routinely performed ultrasonography in patients with Crohn disease.
abstract: BACKGROUND
  In active Crohn disease (CD), abdominal ultrasound can demonstrate morphological changes in the bowel wall. By contrast, the role of ultrasonography in periods with no disease activity has never been evaluated. In this prospective study we investigated the outcome of routinely performed abdominal ultrasonography in CD patients irrespective of symptoms and disease activity.
  
  
  METHODS
  255 consecutive patients with chronic CD (117 M, 138 F, mean age (+/-s) 38 +/- 14) were evaluated by high-resolution ultrasonography of the bowel wall and abdomen. The findings were graded with respect to further diagnostic and/or therapeutic implications. In addition, the CD activity index (CDAI) was determined. In patients with pathological sonographic findings, complementary procedures (e.g. endoscopy, computed tomography, biopsy or operation) were performed to validate the suspected diagnosis.
  
  
  RESULTS
  In 46/255 (18%) patients with CD, the diagnosis of a transmural inflammatory reaction (TMR) with or without fistula was made by ultrasonography. In respect of CDAI, 29/46 (63%) of these patients were graded as active disease (CDAI > 150) and 17/46 (37%) as inactive disease (CDAI < or = 150). Of the 17 patients with a TMR and CDAI < or = 150, 4 patients revealed interenteric fistula, 7 patients mesenteric or perirectal fistula, whereas 6 patients presented with a transmural mesenteric inflammatory reaction without fistula. All fistulae were confirmed by radiography. Ultrasonography of the remaining abdominal organs revealed pathological findings with further diagnostic implications in 25/255 (10%) patients and with therapeutic implications in 9/255 (4%) patients.
  
  
  CONCLUSIONS
  Routinely performed ultrasonography of the abdomen reveals pathological findings with therapeutic implications not only in symptomatic but also in asymptomatic patients with CD. It can therefore be recommended as a screening tool for this group of patients.
authors.affiliation: Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.
authors.forename: T O
authors.initials: TO
authors.lastname: Hirche
authors.forename: J
authors.initials: J
authors.lastname: Russler
authors.forename: O
authors.initials: O
authors.lastname: Schröder
authors.forename: G
authors.initials: G
authors.lastname: Schuessler
authors.forename: P
authors.initials: P
authors.lastname: Kappeser
authors.forename: W F
authors.initials: WF
authors.lastname: Caspary
authors.forename: C F
authors.initials: CF
authors.lastname: Dietrich
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging / Q000503:physiopathology; D000328:Adult; D000553:Ambulatory Care; D003199:Computer Systems; D003424:Crohn Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003955:Diagnostic Tests, Routine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014463:Ultrasonography