title: Changes in Na(+)-K(+)-Cl(-) cotransporter immunoreactivity in the gerbil hippocampus following transient ischemia.
abstract: We examined alterations in Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) immunoreactivity following ischemia. Twelve hours after ischemia, NKCC1 immunoreactivity in the CA1 region and in the hilar region was significantly diminished. Twenty-four hours after ischemia, NKCC1 immunoreactivity was intensified in these hippocampal regions as well as CA2-3. Two days after ischemia, NKCC1 immunoreactivity in the CA1 and the hilar neurons had disappeared, although in the CA2-3 and the granule cell layer NKCC1 immunoreactivities had recovered to the sham level. This finding suggests that NKCC1 may play an important role in the ischemic neuronal injury induced by excitotoxicity as well as neuronal edema.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Kangwon-Do 200-702, Chunchon, Republic of Korea.
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Seung Kook
authors.initials: SK
authors.lastname: Park
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Dae Kun
authors.initials: DK
authors.lastname: Yoon
authors.forename: Hyo Sun
authors.initials: HS
authors.lastname: Shin
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D028021:Sodium-Potassium-Chloride Symporters / Q000378:metabolism*; D064506:Solute Carrier Family 12, Member 2; D013997:Time Factors; D015854:Up-Regulation / Q000502:physiology
chemical_list: D028021:Sodium-Potassium-Chloride Symporters; D064506:Solute Carrier Family 12, Member 2