Polymorphisms of vitamin D receptor gene in Japanese patients with psoriasis vulgaris.
We examined polymorphisms of vitamin D receptor (VDR) gene in Japanese patients with psoriasis vulgaris (PsV). We also studied the association between VDR gene polymorphisms and the response to vitamin D (VD) topical treatment in psoriatic patients. FokI, BsmI, ApaI and TaqI genotypes were determined by restriction fragment patterns in patients (n = 115) and controls (n = 69). In addition, 54 psoriatic patients were divided into two groups in terms of their response to VD (tacalcitol) topical treatment: non-responsive (n = 30) and responsive (n = 24) patients. The frequencies of B allele and t allele were lower in patients than in controls (9 vs. 19%: p < 0.01, 7 vs. 14%: p < 0.05, respectively). In regard to response to VD treatment, F allele was lower in non-responsive patients than in controls (47 vs. 64%, p < 0.05). We show that polymorphisms of VDR gene are associated with Japanese patients with PsV. Allelic variance in the VDR gene or other genes in linkage disequilibrium with this gene might predispose to the development of PsV.
Saeki
Hidehisa
H
Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. saeki-der@h.u.tokyo.ac.jp
Asano
Noriko
N
Tsunemi
Yuichiro
Y
Takekoshi
Tomonori
T
Kishimoto
Megumi
M
Mitsui
Hiroshi
H
Tada
Yayoi
Y
Torii
Hideshi
H
Komine
Mayumi
M
Asahina
Akihiko
A
Tamaki
Kunihiko
K
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D003879:Dermatologic Agents / Q000627:therapeutic use; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D016896:Treatment Outcome
D003879:Dermatologic Agents; D004100:Dihydroxycholecalciferols; D018167:Receptors, Calcitriol; C023850:1 alpha,24-dihydroxyvitamin D3