Diabetes mellitus associated with Klinefelter's syndrome: a case report and review in Japan.
We report a case of Klinefelter's syndrome in a 48-year-old man who had diabetes mellitus associated with severe insulin resistance. We diagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47,XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelter's syndrome in Japanese patients including this case.
Ota
Kikuko
K
Second Department of Internal Medicine, Kochi Medical School.
Suehiro
Tadashi
T
Ikeda
Yukio
Y
Arii
Kaoru
K
Kumon
Yoshitaka
Y
Hashimoto
Kozo
K
D001786:Blood Glucose; D041321:Chromosomes, Human, X; D003920:Diabetes Mellitus / Q000209:etiology* / Q000628:therapy; D003940:Diagnostic Techniques, Endocrine; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007564:Japan; D007713:Klinefelter Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012729:Sex Chromosome Aberrations
D001786:Blood Glucose; D007328:Insulin