title: Low-grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features.
abstract: The current classification system of renal tumors is based on morphologic criteria, as supported by genetic findings. We present a group of previously unclassified tumors with similar morphologic and genetic features, suggesting a new entity within renal neoplasms. Seven renal tumors from five patients (ages 31-67 years) were analyzed. All cases were stained with periodic acid-Schiff, Hale's colloidal iron (HCI), and Alcian blue (AB) at pH 2.5/1.0 with and without hyaluronidase (HA) digestion. Immunohistochemical (IHC) stains were performed for CK8, CK18, CK19, vimentin, villin, Tamm-Horsfall protein (THP), renal cell carcinoma marker (RCC), epithelial membrane antigen (EMA), ulex europaeus agglutinin (UEA-1), soy bean agglutinin (SBA), peanut agglutinin (PNA), and MIB-1. Comparative genomic hybridization (CGH) and loss of heterozygosity (LOH) studies were performed on all cases. All tumors showed circumscribed growth, a tubular growth pattern with focal solid areas, no significant nuclear atypia and absence of necrosis, desmoplasia, or inflammation. Abundant extracellular mucin was present. Immunohistochemistry stains support collecting duct origin (EMA+, PNA+, SBA+/-, CK 8/18/19+, vimentin+/-, UEA-1-, RCC-, villin-, THP-). The proliferative rate was low (<1%). CGH showed multiple consistent chromosomal losses (-1,-4, -6, -8, -9, -13, -14, -15, -22). Clinical outcome was favorable, with recurrences but no known distant metastases or death of disease. These findings are distinct from all previously classified renal neoplasms. Our data suggest the presence of a unique tumor entity within tumors of probable collecting duct origin: tubular-mucinous renal tumors of low malignant potential.
authors.affiliation: Department of Pathology, University Witten Herdecke, Wuppertal, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Rakozy
authors.forename: G E
authors.initials: GE
authors.lastname: Schmahl
authors.forename: S
authors.initials: S
authors.lastname: Bogner
authors.forename: S
authors.initials: S
authors.lastname: Störkel
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D007668:Kidney / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019656:Loss of Heterozygosity; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D009077:Mucins / Q000378:metabolism; D009693:Nucleic Acid Hybridization / Q000379:methods; D019887:Peanut Agglutinin / Q000032:analysis
chemical_list: D019394:Ki-67 Antigen; D018396:Mucin-1; D009077:Mucins; D019887:Peanut Agglutinin; D007633:Keratins