title: High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study.
abstract: High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are very common in VaD as well as in other types of dementia. Therefore, the role of white matter changes in the cognitive and memory decline that occurs in VaD patients is still under debate. High-b DWI, analyzed using the q-space approach, is a more sensitive MRI method for detection of white matter changes. High-b DWI revealed massive white matter loss in VaD patients that surpassed the boundaries of T2 hyperintensities. This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease.
authors.affiliation: Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel. assafyan@post.tau.ac.il
authors.forename: Y
authors.initials: Y
authors.lastname: Assaf
authors.forename: O
authors.initials: O
authors.lastname: Mayzel-Oreg
authors.forename: A
authors.initials: A
authors.lastname: Gigi
authors.forename: D
authors.initials: D
authors.lastname: Ben-Bashat
authors.forename: M
authors.initials: M
authors.lastname: Mordohovitch
authors.forename: R
authors.initials: R
authors.lastname: Verchovsky
authors.forename: I I
authors.initials: II
authors.lastname: Reider-Groswasser
authors.forename: T
authors.initials: T
authors.lastname: Hendler
authors.forename: M
authors.initials: M
authors.lastname: Graif
authors.forename: Y
authors.initials: Y
authors.lastname: Cohen
authors.forename: A D
authors.initials: AD
authors.lastname: Korczyn
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology; D001921:Brain / Q000473:pathology*; D015140:Dementia, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011336:Probability