title: Independent actions on fear circuits may lead to therapeutic synergy for anxiety when combining serotonergic and GABAergic agents.
abstract: Both serotonin and GABA powerfully regulate the neuroanatomical circuit that mediates fear in anxiety disorders. This suggests that use of pharmacotherapies acting on both systems may provide synergistic therapeutic actions.
authors.affiliation: Neuroscience Education Institute, Carlsbad, CA 92009, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D000679:Amygdala / Q000187:drug effects; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D004357:Drug Synergism; D005239:Fear / Q000187:drug effects* / Q000502:physiology; D018682:GABA Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D018490:Serotonin Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D018682:GABA Agents; D018490:Serotonin Agents; D012701:Serotonin; D005680:gamma-Aminobutyric Acid