title: Effect on mood of subthalamic DBS for Parkinson's disease: a consecutive series of 24 patients.
abstract: A series of 24 consecutive PD patients were prospectively studied prior to and within 6 months postoperatively for mood, motor, and cognitive status to investigate the effects on mood of subthalamic deep brain stimulation (DBS) in PD. In six patients (25%), mood state worsened significantly, and three were transiently suicidal despite clear motor improvement. Caregivers and patients should be educated about the potential impact of this neurosurgical procedure on mood.
authors.affiliation: Department of Psychiatry, CHUV, Lausanne, Switzerland. aberne1@po-box.mcgill.ca
authors.forename: A
authors.initials: A
authors.lastname: Berney
authors.forename: F
authors.initials: F
authors.lastname: Vingerhoets
authors.forename: A
authors.initials: A
authors.lastname: Perrin
authors.forename: P
authors.initials: P
authors.lastname: Guex
authors.forename: J-G
authors.initials: JG
authors.lastname: Villemure
authors.forename: P R
authors.initials: PR
authors.lastname: Burkhard
authors.forename: C
authors.initials: C
authors.lastname: Benkelfat
authors.forename: J
authors.initials: J
authors.lastname: Ghika
mesh_terms: D000328:Adult; D000339:Affect; D000368:Aged; D003071:Cognition; D003863:Depression / Q000209:etiology; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology / Q000628:therapy*; D011446:Prospective Studies; D011597:Psychomotor Performance; D020531:Subthalamic Nucleus / Q000502:physiology*