Potential roles of cellular proteins in HIV-1.
Human immunodeficiency virus type-1 particles contain host proteins, both on their surface and interior. This review summarises the cellular proteins found in these virions and covers some of their potential roles in the viral life cycle and pathogenesis. For most proteins studied, their role and function are either unknown or in the hypothesis stage. This reflects the relatively recent emphasis given to these proteins by the HIV-1 field as well as the incomplete understanding of their function in the cell. The study of cellular proteins in HIV-1 promises to help us better understand the interaction of this virus with the cell, the immune system, and the whole human host as well as to shed light on the nature of AIDS and suggest more targets for therapeutic intervention. Finally, many of the cell systems themselves are still poorly understood. The extensive study of HIV-1 has already brought increased attention to the fields of immunology and vaccine science and, in the same way, might assist our understanding of the cellular pathways themselves.
Ott
David E
DE
AIDS Vaccine Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA. ott@ncifcrf.gov
D000954:Antigens, Surface / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D014771:Virion / Q000378:metabolism*
D000954:Antigens, Surface; D008565:Membrane Proteins; D011506:Proteins