title: Anticancer activity for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and their abilities to interact with lymphoendothelial cell surface markers.
abstract: The structure of the anticancer agent 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007's moieties. Analogue anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed.
authors.affiliation: DEKK-TEC, Inc, New Orleans, LA 70119, USA.
authors.forename: Lee Roy
authors.initials: LR
authors.lastname: Morgan
authors.forename: Branko S
authors.initials: BS
authors.lastname: Jursic
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Hooper
authors.forename: Donna M
authors.initials: DM
authors.lastname: Neumann
authors.forename: Kanappan
authors.initials: K
authors.lastname: Thangaraj
authors.forename: Blaise
authors.initials: B
authors.lastname: LeBlanc
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D003713:Dendritic Cells / Q000187:drug effects / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
chemical_list: C097674:4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone; D015703:Antigens, CD; D000970:Antineoplastic Agents; D006835:Hydrazones; D010636:Phenols