Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy.
Stathmin is a member of a novel class of microtubule-destabilizing proteins that regulate the dynamics of microtubule polymerization and depolymerization. Stathmin promotes microtubule depolymerization during interphase and late mitosis. This microtubule depolymerizing activity of stathmin is regulated by changes in its level of phosphorylation that occur during cell cycle progression. These modifications allow it to play a critical role in the regulation of the dynamic equilibrium of microtubules during different phases of the cell cycle. Stathmin is expressed at high levels in a wide variety of human cancers. Inhibition of stathmin expression in malignant cells interferes with their orderly progression through the cell cycle and abrogates their transformed phenotype. Thus, stathmin provides an attractive molecular target for disrupting the mitotic apparatus and arresting the growth of malignant cells. In this review, we describe the current understanding of the role of stathmin in the regulation of the mitotic spindle and discuss its potential as a therapeutic target of cancer therapy.
Mistry
Sucharita J
SJ
Department of Medicine, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA.
Atweh
George F
GF
D002453:Cell Cycle; D015316:Genetic Therapy; D006801:Humans; D008868:Microtubule Proteins; D008870:Microtubules / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D010750:Phosphoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008941:Spindle Apparatus / Q000502:physiology*; D050777:Stathmin
D008868:Microtubule Proteins; D010750:Phosphoproteins; C493995:STMN1 protein, human; D050777:Stathmin