title: Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.
abstract: The anti-influenza activity of a series of thiobenzamide fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine is profiled. Axial disposition of the thioamide moiety is essential for potent influenza inhibitory activity.
authors.affiliation: Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.
authors.forename: Kuo Long
authors.initials: KL
authors.lastname: Yu
authors.forename: Albert F
authors.initials: AF
authors.lastname: Torri
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Luo
authors.forename: Christopher
authors.initials: C
authors.lastname: Cianci
authors.forename: Katharine
authors.initials: K
authors.lastname: Grant-Young
authors.forename: Stephanie
authors.initials: S
authors.lastname: Danetz
authors.forename: Lawrence
authors.initials: L
authors.lastname: Tiley
authors.forename: Mark
authors.initials: M
authors.lastname: Krystal
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Meanwell
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006461:Hemolysis / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008561:Membrane Fusion / Q000187:drug effects; D008744:Methylamines / Q000737:chemistry* / Q000494:pharmacology*; D009975:Orthomyxoviridae / Q000187:drug effects*; D011807:Quinolizines / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013854:Thioamides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; C105257:BMY 27709; D008744:Methylamines; D011807:Quinolizines; D013854:Thioamides; C015539:thiobenzamide; C027451:methylamine