Arachidonate 5-lipoxygenase.
In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylation of 5-lipoxygenase, interaction with other proteins, and the intracellullar mobility of 5-lipoxygenase, are reviewed.
Rådmark
Olof
O
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. olof.radmark@mbb.ki.se
D058927:5-Lipoxygenase-Activating Proteins; D048868:Adaptor Proteins, Signal Transducing; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004722:Endoribonucleases / Q000378:metabolism; D004789:Enzyme Activation; D051380:GRB2 Adaptor Protein; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008054:Lipid Peroxides / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000378:metabolism; D043244:Ribonuclease III
D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D048868:Adaptor Proteins, Signal Transducing; C118115:COTL1 protein, human; D002352:Carrier Proteins; D051380:GRB2 Adaptor Protein; C495948:GRB2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008054:Lipid Peroxides; D008565:Membrane Proteins; D008840:Microfilament Proteins; D011506:Proteins; C111893:TGFBRAP1 protein, human; D000255:Adenosine Triphosphate; D001094:Arachidonate 5-Lipoxygenase; D004722:Endoribonucleases; D043244:Ribonuclease III; D002118:Calcium