title: Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives.
abstract: Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N(4)-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Bharti
authors.forename: Kakul
authors.initials: K
authors.lastname: Husain
authors.forename: M T
authors.initials: MT
authors.lastname: Gonzalez Garza
authors.forename: Delia E
authors.initials: DE
authors.lastname: Cruz-Vega
authors.forename: J
authors.initials: J
authors.lastname: Castro-Garza
authors.forename: Benito D
authors.initials: BD
authors.lastname: Mata-Cardenas
authors.forename: Fehmida
authors.initials: F
authors.lastname: Naqvi
authors.forename: Amir
authors.initials: A
authors.lastname: Azam
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000494:pharmacology; D000588:Amines / Q000737:chemistry; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004748:Entamoeba histolytica / Q000187:drug effects; D016829:Giardia lamblia / Q000187:drug effects; D020128:Inhibitory Concentration 50; D021261:Parasitic Sensitivity Tests; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000447:Aldehydes; D000588:Amines; D000981:Antiprotozoal Agents; D013438:Sulfhydryl Compounds; D013882:Thiosemicarbazones