Intraobserver and interobserver reproducibility of ultrasound measurements of endometrial thickness in postmenopausal women.
OBJECTIVE
To determine intraobserver and interobserver reproducibility of ultrasound measurements of endometrial thickness in postmenopausal women.


METHODS
Forty-eight postmenopausal women underwent transvaginal ultrasound examination by two examiners. Each observer took three replicate measurements of the endometrium in each woman. Intraobserver repeatability was expressed as the difference between the highest and lowest measurement values obtained by one observer, the repeatability coefficient, and the intraclass correlation coefficient. Interobserver reproducibility was expressed as the difference between the mean of the three measurements of each observer, limits of agreement, and interclass correlation coefficient. The repeatability coefficient and the limits of agreement define the range within which 95% of the differences between two measurements are likely to fall. Data were analyzed for all women, as well as separately for women with endometrium < or = 6 mm and > 6 mm. The agreement between observers in classifying women as having endometrium < or = 4.4 mm or > or= 4.5 mm was determined by calculating Cohen's kappa.


RESULTS
In women with endometrium <or = 6 mm the intraclass correlation coefficient was 0.95 for Observer 1 and 0.88 for Observer 2, the median difference between the highest and lowest values being 0.4 mm (range, 0-1.4) for Observer 1 and 0.7 mm (range, 0.1-2.2) for Observer 2, and the repeatability coefficient was 0.8 mm and 1.4 mm, respectively. The corresponding figures for women with endometrium > 6 mm were 0.99 and 0.99, 0.7 mm (0-2.9) and 1.0 mm (0.2-3.4), and 1.7 mm and 1.9 mm. In women with endometrium < or = 6 mm the interclass correlation coefficient was 0.77, and the mean interobserver difference was 0.2 mm +/- 1.8 mm (2 standard deviations), when calculations were based on the mean of three measurements per observer (+/- 1.9 mm when calculations were based on only one measurement per observer). The corresponding figures for women with endometrium > 6 mm were 0.98, 0.2 mm +/- 3.1 mm (+/- 3.2 mm). The agreement between observers in classifying women as having an endometrium < or = 4.4 mm or > or = 4.5 mm was very good (kappa 0.81).


CONCLUSIONS
The reproducibility of endometrial measurements seems to be clinically acceptable and to allow reliable discrimination between postmenopausal women with endometrium < or = 4.4 mm and > or = 4.5 mm. In clinical practice, it is enough to take one endometrial measurement when performing transvaginal ultrasound examination.
Epstein
E
E
Department of Obstetrics and Gynaecology, Malmö University Hospital, University of Lund, Malmö, Sweden.
Valentin
L
L
D000368:Aged; D000704:Analysis of Variance; D004717:Endometrium / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D015588:Observer Variation; D017698:Postmenopause; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000000981:diagnostic imaging* / Q000473:pathology