title: Highly efficient synthesis of chiral beta-amino acid derivatives via asymmetric hydrogenation.
abstract: The Rh-TangPhos complex is an efficient hydrogenation catalyst for making chiral beta-amino acid derivatives. With the Rh-TangPhos system, high enantioselectivities (up to 99.6%) and turnover numbers have been obtained in the hydrogenation of E/Z isomeric mixtures of both beta-alkyl and beta-aryl beta-(acylamino)acrylates. [reaction: see text]
authors.affiliation: Department of Chemistry, The Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Tang
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D012997:Solvents