title: Platelet monoamine oxidase B in family history positive and family history negative type 1 alcohol-dependent subjects.
abstract: OBJECTIVE
  In the present study platelet monoamine oxidase B (MAO-B) activity was investigated in 76 male type 1 alcohol-dependent subjects with and without a family history of alcoholism.
  
  
  RESULTS
  Platelet MAO-B activity did not differ between family history positive (FHP) and family history negative alcohol-dependent subjects. The smoking status of the subjects was registered and there was still no difference between the groups when possible effects of smoking were taken into account. It should, however, be noted that platelet MAO-B activity was lower in alcohol-dependent subjects with three or four alcohol-dependent first-degree relatives.
  
  
  CONCLUSIONS
  Although this latter finding should be interpreted with caution due to the small number of subjects, it cannot be excluded that FHP alcohol-dependent subjects with a large number of alcohol-dependent first-degree relatives may have lower platelet MAO-B activity.
authors.affiliation: The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital/Mölndal, SE-431 80 Mölndal, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: Berggren
authors.forename: Matts
authors.initials: M
authors.lastname: Eriksson
authors.forename: Claudia
authors.initials: C
authors.lastname: Fahlke
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Jan
authors.initials: J
authors.lastname: Balldin
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D001792:Blood Platelets / Q000201:enzymology*; D006801:Humans; D007407:Interviews as Topic; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood* / Q000235:genetics
chemical_list: D008995:Monoamine Oxidase