title: Factors associated with falls in older patients with diffuse polyneuropathy.
abstract: OBJECTIVE
  To identify clinical factors associated with falls by older persons with polyneuropathy (PN).
  
  
  METHODS
  A cross-sectional study of 82 subjects aged 50 to 85 with clinical and electrodiagnostic evidence of PN.
  
  
  METHODS
  Electrodiagnostic and biomechanical research laboratories.
  
  
  METHODS
  Patients referred to the electrodiagnostic laboratory.
  
  
  METHODS
  History and physical examination, including semiquantitative methods of peripheral nerve function, and clinical balance testing. Falls were defined by retrospective self-report over a 2-year period.
  
  
  RESULTS
  Forty (48.8%), 28 (34.1%), and 18 (22.0%) subjects reported a history of at least one fall, multiple falls, and injurious falls, respectively. Factors associated with single and multiple falls were similar, so only results for multiple and injurious falls are reported. Bivariate analysis showed that an increased body mass index (BMI) and more severe PN (as determined by the Michigan Diabetes Neuropathy Score) were associated with both fall categories. Men reporting falls also demonstrated a decreased unipedal stance time. Age, sex, nerve conduction study parameters, Romberg testing, medications, and comorbidities were not consistently associated with either fall category. Logistic regression demonstrated that multiple and injurious falls were associated with an increased BMI and more severe PN, controlling for age, sex, medications, and comorbidities (pseudo R2 = 0.458 and 0.484, respectively).
  
  
  CONCLUSIONS
  Although previous work has demonstrated that all older persons with PN are at increased risk for falls, patients with increased BMI and more severe PN are at particularly high risk and should be targeted for intervention.
authors.affiliation: University of Michigan Medical Center, Department of Physical Medicine and Rehabilitation, Ann Arbor, Michigan 48109, USA. jkrich@umich.edu
authors.forename: James K
authors.initials: JK
authors.lastname: Richardson
mesh_terms: D000058:Accidental Falls; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000150:complications* / Q000503:physiopathology; D011187:Posture / Q000502:physiology; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors