Protein-cleaving catalyst selective for protein substrate.
A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. [reaction: see text]
Jeon
Joong Won
JW
School of Chemistry and Center for Molecular Catalysis, Seoul National University, Seoul 151-747, Korea.
Son
Sang Jun
SJ
Yoo
Chang Eun
CE
Hong
In Seok
IS
Song
Jung Bae
JB
Suh
Junghun
J
D001483:Base Sequence; D001665:Binding Sites; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D007202:Indicators and Reagents; D007700:Kinetics; D020135:Peptide Nucleic Acids / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013379:Substrate Specificity
D007202:Indicators and Reagents; D020135:Peptide Nucleic Acids; D011506:Proteins