Synthesis of the eight enantiomerically pure diastereomers of the 12-F(2)-isoprostanes.
Syntheses of the eight enantiomerically pure diastereomers of the 12-F(2)-isoprostanes (4-11) are described. The key steps included rhodium-mediated intramolecular cyclopropanation and enzymatic resolution of the racemic diol 12.
Taber
Douglass F
DF
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA. taberf@udel.edu
Xu
Ming
M
Hartnett
John C
JC
D028421:Isoprostanes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D028421:Isoprostanes