title: Effect of sodium bicarbonate administration on metabolic responses to maximal exercise.
abstract: Administration of bicarbonate has been shown to cause metabolic alkalosis both in man and in horses and is, therefore, thought to increase the buffering capacity of the body and thereby delay the onset of fatigue. However, results regarding the influence of sodium bicarbonate loading on performance both in human athletes and in horses are conflicting. The aim of this study was, therefore, to investigate the metabolic response to a standardised treadmill exercise test to fatigue, in horses given bicarbonate (0.6 g/kg bwt), in comparison to horses given placebo (water). Five Standardbred trotters performed the test on 2 occasions. Venous blood samples were collected before and after administration of test substance, during exercise and during recovery. Muscle biopsy specimens were taken at rest, postexercise and at 15 min of recovery. The increases in pH and concentration of bicarbonate in the blood and the shift seen in base excess showed that the administration of sodium bicarbonate caused metabolic alkalosis. Exercise caused similar decreases in muscle ATP, CP and glycogen and similar increases in muscle IMP, lactate and plasma lactate and uric acid concentrations both in the placebo- and bicarbonate-treated group. The effect upon postexercise muscle and plasma metabolites was similar with both test treatments. Duration of exercise did not change after sodium bicarbonate intake. In conclusion, sodium bicarbonate caused metabolic alkalosis, but did not affect the metabolic response or duration of exercise.
authors.affiliation: Department of Large Animal Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala.
authors.forename: K
authors.initials: K
authors.lastname: Schuback
authors.forename: B
authors.initials: B
authors.lastname: Essén-Gustavsson
authors.forename: S G B
authors.initials: SG
authors.lastname: Persson
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000502:physiology; D000471:Alkalosis / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D018592:Cross-Over Studies; D005080:Exercise Test / Q000662:veterinary; D005260:Female; D006339:Heart Rate; D006734:Horse Diseases / Q000139:chemically induced / Q000378:metabolism*; D006736:Horses / Q000378:metabolism* / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology; D017693:Sodium Bicarbonate / Q000008:administration & dosage*
chemical_list: D017693:Sodium Bicarbonate