Lack of self-control as assessed by a personality inventory is related to reduced volume of supplementary motor area.
The present study was performed to examine the relationship between schizophrenia-related personality and brain morphometry. Magnetic resonance (MR) imaging and schizophrenia-related personality scales extracted from the Minnesota Multiphasic Personality Inventory (MMPI) were administered to 42 university students. Analysis of the relationships between the gray matter segmented from the MR images on a voxel-by-voxel basis through the use of the statistical parametric mapping technique and the schizophrenia-related personality subscale scores from the MMPI revealed that lack of self-control subscale scores were negatively related to the gray matter volume of the supplementary motor area (SMA). Furthermore, it was suggested that self-control including self-inhibition is associated with the density of the SMA, the precuneous and the cerebellar vermis, which govern voluntary movements and motor imagery. These results provide important clues to the neural basis for the disturbance of self commonly observed in schizophrenia spectrum disorders.
Matsui
Mié
M
Department of Psychology, School of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan. mmatsui@ms.toyama-mpu.ac.jp
Yoneyama
Eiichi
E
Sumiyoshi
Tomiki
T
Noguchi
Kyo
K
Nohara
Shigeru
S
Suzuki
Michio
M
Kawasaki
Yasuhiro
Y
Seto
Hikaru
H
Kurachi
Masayoshi
M
D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D002531:Cerebellum / Q000473:pathology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007389:Internal-External Control; D008950:MMPI / Q000706:statistics & numerical data*; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000473:pathology; D011594:Psychometrics; D012016:Reference Values; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D020377:Self Efficacy