title: Dendritic oxazoline ligands in enantioselective palladium-catalyzed allylic alkylations.
abstract: First to fourth generation dendritic substituents based on 2,2-bis(hydroxymethyl)propionic acid and (1R,2S,5R)-menthoxyacetic acid were attached to 2-(hydroxymethyl)pyridinooxazoline and bis[4-(hydroxymethyl)oxazoline] compounds. The new ligands obtained were assessed in palladium-catalyzed allylic alkylations. The first type of ligands exhibited enantioselectivity similar to that of a benzoyl ester derivative, whereas the latter type of ligands afforded products with higher selectivity than the analogous benzoyl ester. The activity of the dendritic catalysts decreased with increasing generation.
authors.affiliation: Department of Fiber and Polymer Technology and Department of Chemistry, Organic Chemistry, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Malkoch
authors.forename: Kristina
authors.initials: K
authors.lastname: Hallman
authors.forename: Serghey
authors.initials: S
authors.lastname: Lutsenko
authors.forename: Anders
authors.initials: A
authors.lastname: Hult
authors.forename: Eva
authors.initials: E
authors.lastname: Malmström
authors.forename: Christina
authors.initials: C
authors.lastname: Moberg