Proton MR spectroscopy of Wernicke encephalopathy.
Two patients with acute thiamine deficiency were examined with thalamic single-voxel proton MR spectroscopy. T2-weighted images exhibited increased signal intensity. N-acetylaspartate (NAA)/creatine (Cr) ratios were low without detectable lactate. Owing to substantially decreased choline (Cho) T2, the Cho/Cr ratio was not decreased. After thiamine therapy, the NAA/Cr ratio increased, paralleling clinical improvement and reduction in the areas of signal-intensity changes.
Mascalchi
Mario
M
Department of Clinical Pathophysiology, Radiodiagnostica I, Università di Firenze, Firenze, Italy.
Belli
Giacomo
G
Guerrini
Laura
L
Nistri
Marco
M
Del Seppia
Ines
I
Villari
Natale
N
D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011522:Protons; D013832:Thiamine Deficiency / Q000150:complications / Q000175:diagnosis; D014899:Wernicke Encephalopathy / Q000175:diagnosis* / Q000209:etiology
D011522:Protons