CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells.
Follicular lymphomas (FLs) localize in lymphoid tissues and recapitulate the structure of normal secondary follicles. The chemokine/chemokine receptor pair CXCL13/CXCR5 is required for the architectural organization of B cells within lymphoid follicles. In this study, we showed that CXCL13 was secreted by FL cells. FL cells expressed CXCR5 and migrated in response to CXCL13. Furthermore, we observed a synergistic effect between CXCL13 and CXCL12 (SDF-1), a chemokine produced by stromal cells in lymphoid tissues. The production of CXCL13 by FL cells and CXCL12 by stromal cells probably directs and participates in the accumulation of FL cells within specific anatomic sites.
Husson
Hervé
H
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Freedman
Arnold S
AS
Cardoso
Angelo A
AA
Schultze
Joachim
J
Munoz
Olivier
O
Strola
Giuliana
G
Kutok
Jeffery
J
Carideo
Elizabeth G
EG
De Beaumont
Rosalie
R
Caligaris-Cappio
Federico
F
Ghia
Paolo
P
D017209:Apoptosis; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D023201:CD40 Ligand / Q000494:pharmacology; D002478:Cells, Cultured; D054382:Chemokine CXCL13; D019743:Chemokines, CXC / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D005434:Flow Cytometry; D006801:Humans; D015847:Interleukin-4 / Q000494:pharmacology; D008224:Lymphoma, Follicular / Q000378:metabolism* / Q000473:pathology; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000378:metabolism; D013268:Stimulation, Chemical; D014407:Tumor Cells, Cultured
C110663:CXCL13 protein, human; C095085:CXCR5 protein, human; D054382:Chemokine CXCL13; D019743:Chemokines, CXC; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D023201:CD40 Ligand; D015847:Interleukin-4