Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death.
We report the first death associated with rhabdomyolysis in a patient treated with a statin and a protease inhibitor, which produced a significant drug-drug interaction.
Hare
C Bradley
CB
Division of Infectious Diseases, University of California, San Francisco, California 94110, USA. chare@php.ucsf.edu
Vu
Mai P
MP
Grunfeld
Carl
C
Lampiris
Harry W
HW
D000368:Aged; D004347:Drug Interactions; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D009026:Mortality; D019888:Nelfinavir / Q000009:adverse effects* / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000188:drug therapy / Q000401:mortality*; D019821:Simvastatin / Q000009:adverse effects* / Q000627:therapeutic use
D017320:HIV Protease Inhibitors; D000960:Hypolipidemic Agents; D019821:Simvastatin; D019888:Nelfinavir