Breast-conservation therapy in early-stage breast cancer patients with a positive family history.
BACKGROUND
Our goal was to evaluate the role of breast-conservation therapy in early-stage breast cancer patients with a family history (FH) of breast cancer.


METHODS
Between 1970 and 1994, 1324 female patients with breast cancer were treated with breast-conservation therapy at our institution. From these, we identified 985 patients with stage 0-II breast cancer and who had available information on FH status. FH was considered positive in any patient who had a relative who had been previously diagnosed with breast cancer. Disease-specific survival was calculated from the date of initial diagnosis using the Kaplan-Meier method.


RESULTS
The stage distribution for the 985 patients was as follows: 0 in 65 (7%), I in 500 (51%), and II in 420 (43%). The median age was 50 years (range, 21-88), with a median follow-up time of 8.8 years (range,.25-29). The median tumor size was 1.5 cm. FH was positive in 31%. There were no significant differences in locoregional recurrence, distant recurrence, disease-specific survival, or incidence of contralateral breast cancer in patients with a positive FH versus patients with a negative FH.


CONCLUSIONS
Breast-conservation therapy is not contraindicated in early-stage breast cancer patients with a positive FH.
Vlastos
Georges
G
Department of Obstetrics and Gynecology, Senology Geneva University, Geneva, Switzerland.
Mirza
Nadeem Q
NQ
Meric
Funda
F
Hunt
Kelly K
KK
Mirza
Attiqa N
AN
Newman
Lisa A
LA
Ames
Frederick C
FC
Kuerer
Henry M
HM
Ross
Merrick I
MI
Feig
Barry
B
Babiera
Gildy
G
Buchholz
Thomas A
TA
Hortobagyi
Gabriel N
GN
Singletary
S Eva
SE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000235:genetics / Q000532:radiotherapy / Q000601:surgery*; D000075202:Contraindications; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome