title: Cerebrospinal fluid tissue transglutaminase in vascular dementia.
abstract: The enzyme tissue transglutaminase (tTG), an indicator of acute cell death, is found in brains of Alzheimer's and Huntington's disease patients. tTG, as a specific marker for apoptosis, may therefore be a powerful biochemical marker of the acute degenerating process in vivo and may be useful in discrimination between vascular dementia (VaD) and Alzheimer's disease (AD). It may serve as completion of CSF analysis in diagnosis of dementing disorders and be a simple way of assessing the efficacy of possible new anti-apoptotic drugs.
authors.affiliation: Department of Neurology and Psychiatry, Hospital BHB Eggenberg, Bergstrasse 27, A-8021 Graz, Austria. rm.bonelli@nextra.at
authors.forename: Raphael M
authors.initials: RM
authors.lastname: Bonelli
authors.forename: Andreas
authors.initials: A
authors.lastname: Aschoff
authors.forename: Gustaf
authors.initials: G
authors.lastname: Jirikowski
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid; D015415:Biomarkers; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid*; D006801:Humans; D011503:Transglutaminases / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016875:tau Proteins; D011503:Transglutaminases