Host range and receptor binding properties of vectors bearing feline leukemia virus subgroup B envelopes can be modulated by envelope sequences outside of the receptor binding domain.
To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs is mediated primarily by the receptor binding domain; however, in the case of FeLV-B-90Z, the C terminus also contributes to the recognition of certain Pit1 orthologs.
Faix
Peggy Ho
PH
Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
Feldman
Steven A
SA
Overbaugh
Julie
J
Eiden
Maribeth V
MV
D000818:Animals; D002415:Cats; D002460:Cell Line; D005822:Genetic Vectors; D005256:Leukemia Virus, Feline / Q000145:classification / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D051379:Mice; D008907:Mink; D017434:Protein Structure, Tertiary; D011817:Rabbits; D051381:Rats; D011991:Receptors, Virus / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D012190:Retroviridae / Q000235:genetics; D013045:Species Specificity; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D014774:Virulence
D011991:Receptors, Virus; D011993:Recombinant Fusion Proteins; D014759:Viral Envelope Proteins; C067981:leukemia virus receptor, gibbon ape