Limbic cortical injury sustained during adulthood leads to schizophrenia-like syndrome.
Within 1 year of severe trauma to the left anterior temporal lobe and minor injury to the frontal lobes, a 35-year-old individual developed classic positive and negative symptoms of schizophrenia. His antipsychotic drug-induced parkinsonism was greater on the left side, suggesting increased left striatal dopaminergic transmission. The authors propose that even in adulthood, significant and selective disruption of fronto-temporal connectivity is sufficient to produce a phenocopy of schizophrenia.
Jaskiw
George E
GE
Louis Stokes Cleveland VAMC General Mental Health Care Line and Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44144, USA. gxj5@po.cwru.edu
Kenny
John F
JF
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D004298:Dopamine / Q000378:metabolism; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000139:chemically induced; D012559:Schizophrenia / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D012720:Severity of Illness Index; D009435:Synaptic Transmission / Q000502:physiology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents; D004298:Dopamine