Cytogenetics and molecular genetics of ovarian cancer.
Genetic alterations identified in human ovarian tumors by conventional banding, fluorescence in situ hybridization, comparative genomic hybridization, chromosome microdissection, loss of heterozygosity, chromosome microcell-mediated chromosome transfer, and microarray gene expression analysis are summarized and correlated. The significance of these findings with respect to pathologic classification and clinical application are discussed.
Wang
Nancy
N
University of Rochester, School of Medicine, New York, USA. nancy_wang@urmc.rochester.edu
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002890:Chromosomes, Human, Pair 20; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005784:Gene Amplification; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D010051:Ovarian Neoplasms / Q000235:genetics*