title: Life span, cancer and non-cancer diseases in mouse exposed to a continuous very low dose of gamma-irradiation.
abstract: OBJECTIVE
  To analyse the life-span and pathologies of mice living under a continuous very low-dose gamma-irradiation.
  
  
  METHODS
  We exposed 300 C57B1/6J female mice, 3 weeks old, to 10 cGy year(-1) gamma-rays while 300 control mice lived in the same room. Irradiation was delivered continuously by thorium nitrate. We kept all the animals until natural death and performed autopsy.
  
  
  RESULTS
  No difference was observed in life-span (mean lifespan +/-SE: 805.2 +/- 9.62 days for controls and 815 +/- 9.57 days for irradiated mice), weight curves or food intake. At autopsy, cancer was present in 40.9% of controls and 37.9% of irradiated mice. They were mainly represented by lymphomas (23.7 and 24.9%) and histiocytic sarcomas (12.6 and 8.7%, respectively, for controls and irradiated mice). Vascular diseases occurred in 24.1% of controls and 23% of irradiated mice. Infections were present at autopsy in 14.1 and 12.3%, respectively, of controls and irradiated animals. No statistical difference was observed at the end of the experiment for cancer or non-cancer diseases between the two groups.
  
  
  CONCLUSIONS
  Continuous 10 cGy year(-1) gamma-irradiation had no adverse effect on malignant or non-malignant diseases in this strain of mouse.
authors.affiliation: Laboratoire d'Histologie-Embrvologie, Faculté de Médecine Toulouse-Rangueil, Toulouse , France. courtade@cict.fr
authors.forename: M
authors.initials: M
authors.lastname: Courtade
authors.forename: C
authors.initials: C
authors.lastname: Billote
authors.forename: G
authors.initials: G
authors.lastname: Gasset
authors.forename: A
authors.initials: A
authors.lastname: Caratero
authors.forename: J P
authors.initials: JP
authors.lastname: Charlet
authors.forename: B
authors.initials: B
authors.lastname: Pipy
authors.forename: C
authors.initials: C
authors.lastname: Caratero
mesh_terms: D000818:Animals; D004194:Disease / Q000209:etiology*; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D007239:Infections / Q000209:etiology; D008136:Longevity / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011829:Radiation Dosage; D011853:Radiobiology; D014652:Vascular Diseases / Q000209:etiology