New tools and concepts for modern organic synthesis.
The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of the general applications and approaches to synthesis using one such technology--solid-supported reagents--that has been shown to significantly improve productivity in the generation of combinatorial libraries and complex target molecules.
Ley
Steven V
SV
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. svl1000@cam.ac.uk
Baxendale
Ian R
IR
D009930:Organic Chemicals / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D009930:Organic Chemicals; D011108:Polymers