A brief assessment of concerns associated with genetic testing for cancer: the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire.
The Multidimensional Impact of Cancer Risk Assessment (MICRA) is a new tool to measure the specific impact of result disclosure after genetic testing. The authors compared its performance with that of questionnaires measuring general and cancer-specific distress. Participants (158 women) responded 1 month after they received genetic test results. The women were divided into 4 standard clinical test result groups: BRCA1/2 positive, BRCA1/2 negative, panel negative, and true negative. Factor analysis supported the formation of 3 subscales: Distress (6 items, alpha = .86), Uncertainty (9 items, alpha = .77), and Positive Experiences (4 items, alpha = .75). All 3 MICRA subscales differentiated participants who were BRCA1/2 positive from the other 3 groups. MICRA thus helps identify subgroups of vulnerable genetic testing participants.
Cella
David
D
Center on Outcomes Research and Education, Evanston Northwestern Healthcare, Illinois 60201, USA. d-cella@northwestern.edu
Hughes
Chanita
C
Peterman
Amy
A
Chang
Chih-Hung
CH
Peshkin
Beth N
BN
Schwartz
Marc D
MD
Wenzel
Lari
L
Lemke
Amy
A
Marcus
Alfred C
AC
Lerman
Caryn
C
D000328:Adult; D005163:Factor Analysis, Statistical; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005820:Genetic Testing / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D009864:Ontario; D015203:Reproducibility of Results; D018570:Risk Assessment; D013315:Stress, Psychological / Q000175:diagnosis* / Q000209:etiology; D011795:Surveys and Questionnaires