Toxicological studies on Stryphnodendron adstringens.
This study was carried out to determine the acute toxicity of total barbatimão extract (LD(50)) after oral administration to mice, and its effect on certain biochemical parameters in plasma of rats after 30 days of administration. The LD(50) value of the extract was 2699 mg/kg. A daily oral administration of extracts at 800 and 1600 mg/kg doses for 30 days caused a decrease in body weight, thymic involution, and an increase of plasma glucose and aspartate aminotransferase levels in the animals. The results showed that the extract administered in a prolonged period produced toxic effects in the experimental animals.
Rebecca
Marcelo Alessandro
MA
Department of Pharmacy and Pharmacology, University of Maringá, Avenida Colombo, 5790, 87020-900, Maringa, PR, Brazil.
Ishii-Iwamoto
Emy Luiza
EL
Grespan
Renata
R
Cuman
Roberto Kenji Nakamura
RK
Caparroz-Assef
Silvana Martins
SM
Mello
João Carlos Palazzo de
JC
Bersani-Amado
Ciomar Aparecida
CA
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae; D007668:Kidney / Q000187:drug effects; D007677:Kidney Function Tests; D007928:Lethal Dose 50; D007962:Leukocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D010947:Plants, Toxic / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts