Mechanisms underling the effects of adaptogens on erythropoiesis during paradoxical sleep deprivation.
We studied the effects of adaptogens extracts of Siberian ginseng, Rhodiola rosea, bergenia, and ginseng and pantohematogen, on erythropoiesis after paradoxical sleep deprivation. Adaptogens stimulated bone marrow erythropoiesis in the early stage, but decreased the count of bone marrow erythrokaryocytes 3-7 days after treatment. The effect of adaptogens on erythropoiesis is associated with modulation of the state of brain neurotransmitter systems followed by changes in functional activity of cells in the hemopoiesis-inducing microenvironment.
Provalova
N V
NV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Skurikhin
E G
EG
Pershina
O V
OV
Suslov
N I
NI
Minakova
M Yu
MY
Dygai
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D028001:Eleutherococcus / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D005894:Panax / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D029771:Rhodiola / Q000378:metabolism; D012892:Sleep Deprivation; D013997:Time Factors
D010936:Plant Extracts