Effects of Gentiana lutea ssp. symphyandra on the central nervous system in mice.
A methanolic extact of Gentiana lutea ssp. symphyandra roots has been investigated for its possible effects on the central nervous system of mice. At doses of 250 and 500 mg/kg (i.p.), the methanol extract of Gentiana roots caused a significant increase in the swimming endurance test and exhibited slight analgesic activity, but no lethality in mice suggesting some activity on the central nervous system. However, there was no indication of sedation or muscular fatigue at the doses employed. HPLC analysis showed that three secoiridoid compounds, gentiopicroside, swertiamarine and sweroside were present and may have been responsible for the CNS effects of the methanol extract of Gentiana lutea ssp. symphyandra roots.
Oztürk
Nilgün
N
Anadolu University, Medicinal and Aromatic Plant and Drug Research Centre-(TBAM), 26470 Eskişehir, Turkey. nozturk@anadolu.edu.tr
Başer
K Hüsnü Can
KH
Aydin
Süleyman
S
Oztürk
Yusuf
Y
Caliş
Ihsan
I
D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D030012:Gentiana; D005960:Glucosides / Q000737:chemistry; D057888:Iridoid Glucosides; D039823:Iridoids / Q000737:chemistry; D008297:Male; D051379:Mice; D005082:Physical Exertion / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D011714:Pyrans / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry; D013550:Swimming
D000700:Analgesics; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D010936:Plant Extracts; D011714:Pyrans; D011753:Pyrones; C012997:gentiopicroside; C013270:swertiamarin; C049412:sweroside