Lead induced increase of blood pressure in female lead workers.
OBJECTIVE
Although lead exposure has, in the absence of mathematical modelling, been believed to elevate blood pressure in females, it is necessary to clarify the relation between lead and blood pressure by eliminating confounding factors in the analysis.


METHODS
Blood lead was measured in 193 female workers, including 123 lead exposed workers. Possible confounding factors were controlled by multiple regression analyses.


CONCLUSIONS
Blood lead above 40 micro g/dl was found to be the most potent factor for elevating systolic/diastolic blood pressure. Aging, urine protein, and plasma triglyceride also contributed to systolic/diastolic/pulse pressure increase, but hypertensive heredity did not. Data suggested that lead induced changes in lipoprotein metabolism may play an important role in the lead induced blood pressure increase in female workers.
Nomiyama
K
K
Department of Occupational and Environmental Health, Jichi Medical School, Tochigi-Ken 329-0498, Japan. nomiyama@jichi.ac.jp
Nomiyama
H
H
Liu
S-J
SJ
Tao
Y-X
YX
Nomiyama
T
T
Omae
K
K
D000293:Adolescent; D000328:Adult; D000622:Aminolevulinic Acid / Q000097:blood / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects*; D015986:Confounding Factors, Epidemiologic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000139:chemically induced*; D007854:Lead / Q000009:adverse effects / Q000097:blood*; D008074:Lipoproteins / Q000378:metabolism; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011507:Proteinuria / Q000139:chemically induced; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D007854:Lead; D000622:Aminolevulinic Acid