Cytogenetics and molecular genetics of bone and soft-tissue tumors.
The cytogenetic and molecular findings in bone and soft-tissue sarcomas are summarized. A table presenting all such tumors, with their specific translocations and the genes involved, is included, along with a list of those tumors that most likely result from a stepwise process of numerous genetic changes.
Sandberg
Avery A
AA
Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA. jvaugha@chw.edu
D001859:Bone Neoplasms / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005354:Fibrosarcoma / Q000235:genetics; D006801:Humans; D018201:Nephroma, Mesoblastic / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic