Recombinational repair and restart of damaged replication forks.
Genome duplication necessarily involves the replication of imperfect DNA templates and, if left to their own devices, replication complexes regularly run into problems. The details of how cells overcome these replicative 'hiccups' are beginning to emerge, revealing a complex interplay between DNA replication, recombination and repair that ensures faithful passage of the genetic material from one generation to the next.
McGlynn
Peter
P
Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK. peter.mcglynn@nottingham.ac.uk
Lloyd
Robert G
RG
D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology; D006801:Humans; D011387:Prokaryotic Cells / Q000502:physiology; D011995:Recombination, Genetic