A practical high through-put continuous process for the synthesis of chiral cyanohydrins.
A practical high through-put continuous process for the synthesis of chiral cyanohydrins is reported. Pretreated almond meal (or other solid raw enzyme sources) was loaded in a column to form a reactor, to which were attached a supplying system to deliver a solution of substrate and HCN in solvent on one end and a collecting-separating system on the other end. By controlling the flowing rate, optimal conditions were achieved for the hydrocyanation of various aromatic carboxaldehydes in a "micro-aqueous" medium to produce chiral cyanohydrins in high yields and high enantiomeric excess (ee) with high substrate/catalyst ratio.
Chen
Peiran
P
Shanghai Insistitute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
Han
Shiqing
S
Lin
Guoqiang
G
Li
Zuyi
Z
D000446:Aldehyde-Lyases / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism; D001547:Benzaldehydes / Q000378:metabolism; D009570:Nitriles / Q000138:chemical synthesis*; D027861:Prunus / Q000201:enzymology; D013237:Stereoisomerism
D000447:Aldehydes; D001547:Benzaldehydes; D009570:Nitriles; C430593:cyanohydrin; D000446:Aldehyde-Lyases; C021541:mandelonitrile lyase; C032175:benzaldehyde