1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.
Antiapoptotic agents based on 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole (27), and 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.
Lien
Jin-Cherng
JC
Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan. jclien@mail.cmc.edu.tw
Lee
Fang-Yu
FY
Huang
Li-Jiau
LJ
Pan
Shiow-Lin
SL
Guh
Jih-Hwa
JH
Teng
Che-Ming
CM
Kuo
Sheng-Chu
SC
D000284:Administration, Oral; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D020536:Enzyme Activators / Q000494:pharmacology*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D032342:Muscle Cells / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*; D051381:Rats; D018805:Sepsis / Q000401:mortality
C468784:1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole; C468785:1-phenyl-3-(5'-hydroxymethyl-2'-furyl)indazole; D020536:Enzyme Activators; D007191:Indazoles; D020030:Nitric Oxide Donors; C090937:3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole; D009599:Nitroprusside