Did tRNA synthetase classes arise on opposite strands of the same gene?
Structural homology of class II aminoacyl-tRNA synthetases to the HSP70 family and the existence of a gene whose sense and antisense strands code for a dehydrogenase and an HSP70 chaperonin justify reconsideration of a possible sense-antisense ancestry for the two synthetase classes.
Carter
Charles W
CW
Duax
William L
WL
D000595:Amino Acid Sequence; D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000145:classification* / Q000235:genetics*; D019143:Evolution, Molecular; D005969:Glutamate Dehydrogenase / Q000737:chemistry / Q000235:genetics*; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016372:RNA, Antisense / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D018840:HSP70 Heat-Shock Proteins; D016372:RNA, Antisense; D005969:Glutamate Dehydrogenase; D000604:Amino Acyl-tRNA Synthetases