[Drugs and breastfeeding].
Most drugs taken by the mother reach breast milk and are ingested by the nursing infant. Most of the drugs are detected in breast milk at low concentrations, so breastfeeding by women taking these drugs is possible. The effect of some drugs on the nursing infant is unknown and further studies are needed. Some drugs may achieve significant infant plasma concentrations and may be unsafe for the infant. In these cases the infant should be carefully monitored for any clinical side effects and whenever observed, breastfeeding should be discontinued. Despite the confirmed benefits of breastfeeding, there are certain drugs which are absolutely contraindicated; in these cases interruption of breastfeeding is necessary. This review summarises the current scientific knowledge on compatibility of drugs with breastfeeding, focusing on drugs that are contraindicated and of which use in breastfeeding remains controversial.
Prokopczyk
Jadwiga
J
Zaklad Farmakologii, Instytut Matki i Dziecka, ul. Kasprzaka 17a, Warszawa, Poland. farmakol@imid.med.pl
Kaminska
Ewa
E
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D000928:Antidepressive Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D001942:Breast Feeding; D000697:Central Nervous System Stimulants / Q000009:adverse effects; D000075202:Contraindications; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007774:Lactation / Q000187:drug effects; D008895:Milk, Human / Q000737:chemistry / Q000187:drug effects*; D004364:Pharmaceutical Preparations; D019141:Respiratory System Agents / Q000009:adverse effects; D013443:Sulfisomidine / Q000009:adverse effects
D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D000697:Central Nervous System Stimulants; D007166:Immunosuppressive Agents; D004364:Pharmaceutical Preparations; D019141:Respiratory System Agents; D013443:Sulfisomidine