title: Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane.
abstract: Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate-sensitive K+ channel (mitoKATP), is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoKCa) of guinea pig ventricular cells. MitoKCa significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoKCa protected hearts against infarction.
authors.affiliation: Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Xu
authors.forename: Yongge
authors.initials: Y
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Todd
authors.initials: T
authors.lastname: McDonald
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Van Eyk
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sidor
authors.forename: Brian
authors.initials: B
authors.lastname: O'Rourke
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D018999:Charybdotoxin / Q000494:pharmacology; D019610:Cytoprotection; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006439:Hemodynamics; D007425:Intracellular Membranes / Q000378:metabolism*; D017136:Ion Transport; D051036:Large-Conductance Calcium-Activated Potassium Channels; D008929:Mitochondria, Heart / Q000378:metabolism*; D009203:Myocardial Infarction / Q000517:prevention & control*; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000648:ultrastructure; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism*; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism*
chemical_list: D001562:Benzimidazoles; D051036:Large-Conductance Calcium-Activated Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D018999:Charybdotoxin; C086491:NS 1619; D000255:Adenosine Triphosphate; D011188:Potassium; D002118:Calcium