Gadodiamide as an alternative contrast agent during angioplasty in patients with contraindications to iodinated media.
OBJECTIVE
To evaluate gadodiamide as an alternative contrast agent for peripheral and renal angioplasty in patients with contraindications to iodinated contrast media.


METHODS
Seventeen patients (10 men; mean age 74 years, range 68-83) with contraindication to iodinated contrast media were given gadodiamide as the contrast agent during peripheral and renal intra-arterial digital subtraction angiography (DSA) and subsequent percutaneous interventions (balloon angioplasty, stent placement).


RESULTS
The mean volume of gadodiamide used was 136 +/- 46 mL (range 60-200). No serious side effects were observed, especially no change in renal or thyroid function; no exanthema or other allergic reactions were noted. In patients without renal artery intervention, serum creatinine at discharge remained unchanged (2.57 +/- 1.43 mg/dL to 2.40 +/- 1.28 mg/dL, p=NS). In patients undergoing angioplasty/stenting of renal artery stenoses, serum creatinine decreased significantly from 3.53 +/- 1.75 mg/dL to 2.36 +/- 1.15 mg/dL (p<0.01). All but 1 intervention was successful. Using a simple scoring system, 2 judges blinded to the contrast agent graded the quality of the peripheral DSAs as "good," whereas renal DSA images were only "sufficient."


CONCLUSIONS
For patients with contraindications to iodinated materials, gadodiamide may be a suitable alternative for renal or peripheral DSA followed by angioplasty.
Zeller
Thomas
T
Department of Angiology, Herz-Zentrum Bad Krozingen, Germany. thomas.zeller@herzzentrum.de
Müller
Christian
C
Frank
Ulrich
U
Bürgelin
Karlheinz
K
Sinn
Lutz
L
Horn
Barbara
B
Flügel
Peter C
PC
Roskamm
Helmut
H
D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D000800:Angioplasty, Balloon; D019917:Blood Vessel Prosthesis Implantation; D000075202:Contraindications; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D017613:Iodine Compounds; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D015607:Stents; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology
D003287:Contrast Media; D017613:Iodine Compounds; C064925:gadodiamide; D019786:Gadolinium DTPA