Oxidative stress in ecotoxicology: from the analysis of individual antioxidants to a more integrated approach.
An integrate approach will be discussed for investigations on oxidative stress in xenobiotic toxicity. While the analysis of individual antioxidants is useful for their sensitivity and to understand the mode of action of a stressor, the integration with the analysis of the total antioxidant capacity provides a more holistic assessment of the overall biological significance of such variations. TOSC has a greater predictive value on the health condition of the organisms and allows to discriminate the different role of specific ROS in oxidative stress syndrome.
Regoli
F
F
Istituto di Biologia e Genetica, Università di Ancona, Italy. regoli@popcsi.unian.it
Gorbi
S
S
Frenzilli
G
G
Nigro
M
M
Corsi
I
I
Focardi
S
S
Winston
G W
GW
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004463:Ecology; D004784:Environmental Monitoring; D016166:Free Radical Scavengers; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D014116:Toxicology / Q000639:trends; D015262:Xenobiotics / Q000633:toxicity*
D000975:Antioxidants; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D015262:Xenobiotics