[The role of oxidative stress in the pathogenesis and therapy of chronic wounds].
Molecular oxygen plays a central role in the pathogenesis and therapy of chronic wounds. When reactive oxygen species are overproduced, oxidative stress results, with detrimental cytotoxic effects causing delayed wound healing. Therefore, elimination of reactive oxygen species could be an important strategy to improve healing of chronic wounds. Currently first therapeutic strategies targeting reactive oxygen species by antioxidants are being introduced into the treatment of chronic wounds.
Dissemond
J
J
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie des Universitätsklinikums Essen, Germany. joachimdissemond@hotmail.com
Goos
M
M
Wagner
S N
SN
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002908:Chronic Disease; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000503:physiopathology*
D000975:Antioxidants; D017382:Reactive Oxygen Species