Stress proteins: nomenclature, division and functions.
The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survival and death. In addition to extracellular stimuli, several nonstressfull conditions induce Hsps during normal cellular growth and development. The enhanced heat shock gene expression in response to various stimuli is regulated by heat shock transcription factors.
Kopecek
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P
Department of Biology, Medical Faculty, Palacký University, 775 15 Olomouc, Czech Republic.
Altmannová
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K
Weigl
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D000818:Animals; D006360:Heat-Shock Proteins / Q000145:classification* / Q000235:genetics / Q000502:physiology*; D018869:Heat-Shock Response / Q000502:physiology; D006801:Humans; D009626:Terminology as Topic; D014158:Transcription, Genetic
D006360:Heat-Shock Proteins