title: Kinetic analysis for multiple substrate interaction at the active site of cytochrome P450.
authors.affiliation: Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
authors.forename: Magang
authors.initials: M
authors.lastname: Shou
mesh_terms: D001571:Benzoflavones / Q000378:metabolism; D001665:Binding Sites; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism; D004008:Diclofenac / Q000378:metabolism; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000378:metabolism; D007700:Kinetics; D019808:Losartan / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D011802:Quinidine / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D001571:Benzoflavones; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; D004008:Diclofenac; C011512:alpha-naphthoflavone; D003577:Cytochrome P-450 Enzyme System; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; D011802:Quinidine; D019808:Losartan; D003975:Diazepam