Toxic epidermal necrolysis due to administration of celecoxib (Celebrex).
A 41-year-old woman was given celecoxib (Celebrex) for the treatment of carpal tunnel syndrome. An erythematous rash developed that progressed to exfoliative dermatitis, and the patient was diagnosed with toxic epidermal necrolysis. After transfer to the burn unit, she was treated with topical mupirocin calcium cream and bismuth tribromophenatein petrolatum gauze dressings. Her wounds healed well. This is the first case report of toxic epidermal necrolysis due to treatment with celecoxib of which we are aware.
Friedman
Bruce
B
Joseph M. Still Burn Center, Doctor's Hospital, Augusta, GA, USA.
Orlet
Hermann K
HK
Still
Joseph M
JM
Law
Edward
E
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002349:Carpal Tunnel Syndrome / Q000188:drug therapy; D000068579:Celecoxib; D005260:Female; D006801:Humans; D016712:Mupirocin / Q000008:administration & dosage; D010636:Phenols / Q000008:administration & dosage; D011720:Pyrazoles; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology*; D013449:Sulfonamides / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010636:Phenols; D011720:Pyrazoles; D013449:Sulfonamides; D016712:Mupirocin; D000068579:Celecoxib; C004554:2,4,6-tribromophenol