title: Enantioselective reduction of trifluoromethyl ketones with chiral organomagnesium amides (COMAs).
abstract: Chiral organomagnesium amides (COMAs), readily prepared from dialkylmagnesiums and chiral secondary amines, can reduce trifluoromethyl ketones to form secondary alcohols with excellent enantioselectivities (up to 98:2 er) and chemical yields (typically >95% conversion, >85% isolated yields). These MPV-type reductions use an achiral hydride source, and the chiral amine is readily recovered. [reaction: see text]
authors.affiliation: Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry (GWC)(2), University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Kelvin H
authors.initials: KH
authors.lastname: Yong
authors.forename: J Michael
authors.initials: JM
authors.lastname: Chong