title: Intratympanic gentamicin injections for Meniere disease: vestibular hair cell impairment and regeneration.
abstract: The authors treated 22 patients with intratympanic gentamicin. Vestibular function was measured using caloric and head impulse tests and vestibular evoked myogenic potentials induced by high amplitude sounds and short duration galvanic currents. Roughly one-third of the patients, after initially losing their caloric responses and displaying refixation saccades to head impulse tests, recovered within 2 years of the lesion. Vertigo did not recur in patients in whom the galvanic response was abolished.
authors.affiliation: Service ORL, Hôpital Lariboisière, Paris, France. cdw@ccr.Jussieu.fr
authors.forename: C
authors.initials: C
authors.lastname: De Waele
authors.forename: R
authors.initials: R
authors.lastname: Meguenni
authors.forename: G
authors.initials: G
authors.lastname: Freyss
authors.forename: F
authors.initials: F
authors.lastname: Zamith
authors.forename: N
authors.initials: N
authors.lastname: Bellalimat
authors.forename: P P
authors.initials: PP
authors.lastname: Vidal
authors.forename: P
authors.initials: P
authors.lastname: Tran Ba Huy
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002150:Caloric Tests; D005072:Evoked Potentials, Auditory; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D018069:Hair Cells, Vestibular / Q000473:pathology / Q000502:physiology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009416:Nerve Regeneration; D012438:Saccades; D016896:Treatment Outcome; D014432:Tympanic Membrane
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins