Viral evasion of natural killer cells.
Viruses have evolved mechanisms to avoid the host immune system, including means of escaping detection by both the innate and adaptive immune responses. Natural killer (NK) cells are a central component of the innate immune system and are crucial in defense against certain viruses. To attain a state of chronic infection, some successful viruses have developed specific mechanisms to evade detection by and activation of NK cells. These NK cell-specific evasion mechanisms fall into distinct mechanistic categories used in numerous virus families.
Orange
Jordan S
JS
Department of Molecular and Cellular Biology, Harvard University, Cambridge MA, USA.
Fassett
Marlys S
MS
Koopman
Louise A
LA
Boyson
Jonathan E
JE
Strominger
Jack L
JL
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000235:genetics / Q000502:physiology; D003602:Cytotoxicity, Immunologic; D015536:Down-Regulation; D015967:Gene Expression Regulation, Viral; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology; D051379:Mice; D018448:Models, Immunological; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000235:genetics / Q000276:immunology*
D000956:Antigens, Viral; D018925:Chemokines; D016207:Cytokines; D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic