title: Abdominal compartment syndrome in the open abdomen.
abstract: BACKGROUND
  Multiple methods exist to manage in the intensive care unit the patient with an open abdomen. An increasingly common method is the vacuum packed technique. This method accommodates considerable expansion of intra-abdominal contents and should obviate the potential development of the abdominal compartment syndrome (ACS). Despite this, some patients with these temporary abdominal dressings will go on to develop ACS. For the purpose of this study we have defined this clinical entity as the open abdomen ACS.
  
  
  OBJECTIVE
  Patients with an open abdomen who develop ACS have a poor prognosis. Fluid requirements and resuscitative indices may predict which of these patients will develop open abdomen ACS.
  
  
  METHODS
  A retrospective review was performed of patients with trauma who had an open abdomen treated with vacuum packed dressings at our urban level I trauma center. Over 1 year (July 1, 1999-June 30, 2000), 5 patients managed with an open abdomen developed ACS. These patients were compared with 15 consecutive patients with an open abdomen who did not develop clinical ACS during that same period. Fluid resuscitation, base deficit, pH, lactate level, systolic blood pressure, prothrombin time, temperature, peak inspiratory pressure, and PCO(2) were abstracted. The Fisher exact test was used for statistical analysis.
  
  
  RESULTS
  In patients managed with an open abdomen, ACS developed between 1.5 and 12 hours (mean [SD], 7.5 [3.9] hours) after placement of the vacuum packed dressing. The base deficit, pH, peak inspiratory pressure, PCO(2,) and lactate level were more abnormal and the crystalloid requirements were significantly higher in the ACS group. The systolic blood pressure, temperature, and prothrombin time did not differ between groups. Three patients with ACS developed a second episode of ACS. Mortality in the ACS group was 3 (60%) of 5 patients vs 1 (7%) of 15 patients in the control group.
  
  
  CONCLUSIONS
  Management of the open abdomen with the temporary abdominal closure does not prevent the development of ACS. Mortality is high when ACS occurs in this scenario. Severe physiologic derangement and high crystalloid requirements may predict which patients will develop ACS.
authors.affiliation: Division of Traumatology and Surgical Critical Care, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104-3335. graciasv@uphs.upenn.edu
authors.forename: Vicente H
authors.initials: VH
authors.lastname: Gracias
authors.forename: Benjamin
authors.initials: B
authors.lastname: Braslow
authors.forename: Jon
authors.initials: J
authors.lastname: Johnson
authors.forename: John
authors.initials: J
authors.lastname: Pryor
authors.forename: Rajan
authors.initials: R
authors.lastname: Gupta
authors.forename: Patrick
authors.initials: P
authors.lastname: Reilly
authors.forename: C William
authors.initials: CW
authors.lastname: Schwab
mesh_terms: D000005:Abdomen / Q000503:physiopathology*; D000007:Abdominal Injuries / Q000150:complications*; D000328:Adult; D003161:Compartment Syndromes / Q000209:etiology / Q000401:mortality* / Q000601:surgery*; D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D009779:Occlusive Dressings; D011312:Pressure / Q000009:adverse effects; D012189:Retrospective Studies