Aggressive behavior induced by intraoperative stimulation in the triangle of Sano.
The authors report a patient with advanced PD, successfully treated by bilateral stimulation of the subthalamic nucleus, who developed acute transient aggressive behavior during intraoperative electrical test stimulation. The electrode responsible for this abnormal behavior was located within the lateral part of the posteromedial hypothalamic region (triangle of Sano). The authors suggest that affect can be dramatically modulated by the selective manipulation of deep brain structures.
Bejjani
B P
BP
Parkinson and Movement Disorders Center, Byblos, Université Saint Joseph, Beirut, Lebanon.
Houeto
J L
JL
Hariz
M
M
Yelnik
J
J
Mesnage
V
V
Bonnet
A M
AM
Pidoux
B
B
Dormont
D
D
Cornu
P
P
Agid
Y
Y
D000374:Aggression; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D006801:Humans; D007034:Hypothalamus, Posterior / Q000502:physiology*; D007431:Intraoperative Complications / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery / Q000628:therapy*