title: Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors.
abstract: The crystal structure of rhodopsin has provided the first three-dimensional molecular model for a G-protein-coupled receptor (GPCR). Alignment of the molecular model from the crystallographic structure with the helical axes seen in cryo-electron microscopic (cryo-EM) studies provides an opportunity to investigate the properties of the molecule as a function of orientation and location within the membrane. In addition, the structure provides a starting point for modeling and rational experimental approaches of the cone pigments, the GPCRs in cone cells responsible for color vision. Homology models of the cone pigments provide a means of understanding the roles of amino acid sequence differences that shift the absorption maximum of the retinal chromophore in the environments of different opsins.
authors.affiliation: Department of Biological Structure, University of Washington, Seattle, WA 98195, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Stenkamp
authors.forename: S
authors.initials: S
authors.lastname: Filipek
authors.forename: C A G G
authors.initials: CA
authors.lastname: Driessen
authors.forename: D C
authors.initials: DC
authors.lastname: Teller
authors.forename: K
authors.initials: K
authors.lastname: Palczewski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001001:Anura; D001665:Binding Sites; D020285:Cryoelectron Microscopy; D003461:Crystallography; D003593:Cytoplasm / Q000737:chemistry; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry*; D017949:Retinal Cone Photoreceptor Cells / Q000737:chemistry*; D012168:Retinal Pigments / Q000737:chemistry*; D012243:Rhodopsin / Q000737:chemistry*; D017299:Rod Opsins / Q000737:chemistry
chemical_list: D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D012168:Retinal Pigments; D017299:Rod Opsins; D012243:Rhodopsin