TCR gene-rearranged, extranodal NK/T-cell lymphoma, nasal type, presenting as gyrate patches.
In the CD56+ cutaneous nasal-type NK/T-cell lymphoma strongly associated with latent EBV infection, subcutaneous or dermal nodules are the most common skin findings, but great morphologic heterogeneity has been noted including papules, infiltrated plaques, and ulcerated tumors, and TCR genes are mostly germline. We describe a case of nasal and nasal-type NK/T-cell lymphoma featuring multiple erythematous polycyclic patches on the trunk, which is similar to patch stage mycosis fungoides or other cutaneous T cell lymphoma. Immunohistochemical study of a skin biopsy specimen revealed CD2+, CD3epsilon+, CD56+, and CD45RO+ expression in the neoplastic cells. In situ hybridization using an anti-sense Epstein Barr virus early regions probe showed a positive reaction. However, clonal TCR beta gene rearrangement was found.
Hwang
Dong-Kyu
DK
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Kwon
Hyeok-Man
HM
Park
Jin-Woo
JW
Yu
Hee-Joon
HJ
Park
Yong Wook
YW
D019002:CD56 Antigen / Q000032:analysis; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*
D019002:CD56 Antigen