title: Intra-articular morphine and postoperative analgesia after knee arthroscopy.
abstract: The aim of this study was to evaluate the postoperative analgesic effect of intra-articular administration of a low- and a high-dose morphine solution after knee arthroscopy. Thirty patients who underwent diagnostic arthroscopy or arthroscopic meniscectomy were allocated in three groups. At the end of the arthroscopic procedure patients in Group A received intra-articularly 20 ml normal saline (N/S), Group B received 5 mg morphine in 20 ml N/S and Group C received 15 mg morphine in 20 ml N/S. The postoperative pain was assessed using a visual analogue scale for 24 h, while all the patients stayed at hospital. Side effects from the central action of opioids were not detected. Although the pain scores in the group of low-dose morphine were lower than in the control group, we failed to detect any significant differences in pain scores among the three groups. There was evidence that a high-dose can cause hyperalgesia.
authors.affiliation: Crete Naval Hospital, Souda, Crete, Greece. drosos@otenet.gr
authors.forename: G I
authors.initials: GI
authors.lastname: Drosos
authors.forename: I G
authors.initials: IG
authors.lastname: Vlachonikolis
authors.forename: A N
authors.initials: AN
authors.lastname: Papoutsidakis
authors.forename: N S
authors.initials: NS
authors.lastname: Gavalas
authors.forename: G
authors.initials: G
authors.lastname: Anthopoulos
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D001182:Arthroscopy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007717:Knee / Q000601:surgery*; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine