Contact allergy and allergic contact dermatitis in adolescents: prevalence measures and associations. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS).
The aims of this cross-sectional study were to establish the prevalence measures of contact allergy and allergic contact dermatitis in 8th grade schoolchildren (aged 12-16 years) in Odense, Denmark, and to examine the associations with atopic dermatitis, inhalant allergy and hand eczema. Contact allergy to a standard series allergen was found in 15.2% of schoolchildren. The point prevalence of allergic contact dermatitis was 0.7% and the lifetime prevalence 7.2%, predominantly in girls. The most common contact allergens were nickel (8.6%) and fragrance mix (1.8%). Nickel allergy was clinically relevant in 69% and fragrance allergy in 29% of cases. A significant association was found between contact allergy and hand eczema while no association was found between contact allergy and atopic dermatitis or inhalant allergy. In the future this cohort of schoolchildren will be followed with regard to the course and development of atopic diseases, hand eczema and contact dermatitis. Key words: school-
Mortz
Charlotte Gotthard
CG
Department of Dermatology, Odense University Hospital, Denmark. mortz@imbmed.ou.dk
Lauritsen
Jens Martin
JM
Bindslev-Jensen
Carsten
C
Andersen
Klaus Ejner
KE
D000280:Administration, Inhalation; D000293:Adolescent; D017677:Age Distribution; D000485:Allergens / Q000009:adverse effects / Q000494:pharmacology; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010328:Patch Tests; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution
D000485:Allergens