title: Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.
abstract: The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.
authors.affiliation: Department of Medicinal Chemistry, Anadys Pharmaceuticals, Inc., San Diego, CA 92121, USA. dvourloumis@anadyspharma.com
authors.forename: Dionisios
authors.initials: D
authors.lastname: Vourloumis
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Winters
authors.forename: Klaus B
authors.initials: KB
authors.lastname: Simonsen
authors.forename: Benjamin K
authors.initials: BK
authors.lastname: Ayida
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.forename: Seema
authors.initials: S
authors.lastname: Qamar
authors.forename: Sarah
authors.initials: S
authors.lastname: Shandrick
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Thomas
authors.initials: T
authors.lastname: Hermann
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D006595:Hexosamines / Q000737:chemistry* / Q000494:pharmacology*; D008156:Luciferases / Q000235:genetics; D008958:Models, Molecular; D014176:Protein Biosynthesis / Q000187:drug effects; D012335:RNA, Ribosomal / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006595:Hexosamines; D012335:RNA, Ribosomal; D008156:Luciferases