Intravascular inhomogeneous oxygen distribution in microvessels: theory.
Cross-sectional oxygen distribution in microvessels in most previous studies has been assumed to be homogeneous. Recent studies using phosphorescence quenching microscopy or microspectrophotometry showed a decline in oxygen profile near the arterial wall. In this study we performed theoretical analysis of intravascular P(O(2)) and S(O(2)) profiles in arterioles by using a radial diffusion model with a constant oxygen efflux from the vascular lumen, taking intravascular flow distribution into account. Theoretical calculations indicated that radial oxygen diffusion and a laminar flow pattern would create inhomogeneous intravascular oxygen profile with a decline toward the arterial wall. As mean blood flow velocity became lower, the difference between the centerline oxygen level and the inner surface level became larger. In conclusion, it is suggested that oxygen efflux from the vascular lumen and less convective supply near the vascular wall create a decline in P(O(2)) as well as S(O(2)) toward the arterial wall.
Kobayashi
Hirosuke
H
Department of Medicine, Kitasato University School of Medicine, Kitasato 1-15-1, Sagamihara, Kanagawa 228-8555, Japan. hiro@kitasato-u.ac.jp
Takizawa
Naosada
N
Negishi
Tomoko
T
Tanishita
Kazuo
K
D001783:Blood Flow Velocity / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000378:metabolism*; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000502:physiology; D010100:Oxygen / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D010100:Oxygen