title: Hostility, the metabolic syndrome, and incident coronary heart disease.
abstract: This invesgation examined the impact of hostility and the metabolic syndrome on coronary heart disease (CHD) using prospective data from the Normative Aging Study. Seven hundred seventy-four older, unmedicated men free of cardiovascular disease were included in the study. The total Cook-Medley Hostility (Ho) Scale score, anthropometric data, serum lipids, fasting insulin concentrations, blood pressure, cigarette smoking, alcohol consumption, and total dietary calories were used to predict incident CHD during a 3-year follow-up interval. Multivariate analysis indicated that only Ho positively predicted and high-density lipoprotein cholesterol level negatively predicted incident CHD. Ho's effects on CHD may be mediated though mechanisms other than factors that constitute the metabolic syndrome.
authors.affiliation: Department of Psychiatry and Human Behavior, Brown Medical School, Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island 02903, USA. raymond_niaura@brown.edu
authors.forename: Raymond
authors.initials: R
authors.lastname: Niaura
authors.forename: John F
authors.initials: JF
authors.lastname: Todaro
authors.forename: Laura
authors.initials: L
authors.lastname: Stroud
authors.forename: Avron
authors.initials: A
authors.lastname: Spiro
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Ward
authors.forename: Scott
authors.initials: S
authors.lastname: Weiss
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001900:Boston / Q000453:epidemiology; D003327:Coronary Disease / Q000453:epidemiology*; D006791:Hostility; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000523:psychology*; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors