Structure of interleukin-10/interleukin-10R1 complex: a paradigm for class 2 cytokine activation.
The class II alpha-helical cytokine family consists of eleven members including the interferons, interleukin-10 (IL-10) and several newly discovered IL-10 homologs. The molecules display a vast array of biologic activities including the ability to induce an antiviral state, modulate inflammatory responses, and inhibit cell growth. Biologic activity is dependent on cytokine-dependent aggregation of two different cell-surface receptors. The detailed protein-protein interactions that initiate these biologic responses are amenable to study using X-ray crystallographic methods. In this article, I summarize my laboratory's contributions to understanding these recognition processes using IL-10 as the prototypic class II cytokine.
Walter
Mark R
MR
Department of Microbiology, University of Alabama at Birmingham, 35294, USA. walter@uab.edu
D001665:Binding Sites; D018360:Crystallography, X-Ray; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000737:chemistry* / Q000378:metabolism; D046911:Macromolecular Substances; D008958:Models, Molecular; D018123:Receptors, Interleukin / Q000737:chemistry* / Q000378:metabolism; D053701:Receptors, Interleukin-10
D016207:Cytokines; D046911:Macromolecular Substances; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10; D016753:Interleukin-10