title: Long-term follow-up of cellular proliferation as a predictive index for the relapse of nasal polyposis.
abstract: BACKGROUND
  The objective of this study was to identify a reproducible clinical parameter for predicting relapses of nasal polyposis after surgery.
  
  
  METHODS
  Ninety-three patients who had undergone ethmoidectomy of bilateral nasal polyps were followed for 3 years. Nasal polyps were obtained from all patients, and cellular suspensions were analyzed individually using flow cytometry. Based on the percentage of cells in the S phase, we identified three groups of patients (high, medium, and low percentages).
  
  
  RESULTS
  A relapse of nasal polyposis was observed in 15.00, 70.00, and 100.00% of patients from the low-, medium-, and high-percentage groups, respectively. Patients suffering relapses had a high percentage of cells in the S phase.
  
  
  CONCLUSIONS
  We identified two cutoff values for the percentage of cells in the S phase; above the first cutoff, some of the patients suffered relapses; above the second cut-off, all patients suffered relapses.
authors.affiliation: Division of Otorhinolaryngology, Faculty of Medicine and Surgery, University of Rome Tor Vergata, Italy.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Bruno
authors.forename: Ehab I
authors.initials: EI
authors.lastname: Mohamed
authors.forename: Marco
authors.initials: M
authors.lastname: Alessandrini
authors.forename: Sabino
authors.initials: S
authors.lastname: Russo
authors.forename: Stefania
authors.initials: S
authors.lastname: Schiaroli
authors.forename: Antonino
authors.initials: A
authors.lastname: De Lorenzo
authors.forename: Alberto
authors.initials: A
authors.lastname: Di Girolamo
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011237:Predictive Value of Tests; D016196:S Phase