[Extracellular matrix metalloproteinases--perspectives of their use in medicine].
Extracellular matrix turnover disturbances are implicated in many human diseases. Matrix Metalloproteinases (MMP) are believed to play a pivotal role in maintaining the intricate balance between extracellular matrix synthesis and degradation. These enzymes are active in the cleavage of many matrix proteins. There is evidence that matrix metalloproteinases activity changes in many pathological conditions, including inflammatory and degenerative disorders as well as tumour progression and metastases. This review focuses on the recent view on physiological and pathological function of MMPs. Authors aimed also to show the putative role of matrix metalloproteinases as a diagnostic tool in future medicine.
Kotulska-Wolwender
Katarzyna
K
Katedry i Kliniki Neurologii, Slaskiej Akademii Medycznej w Katowicach. fzjkatpl@infomed.slam.katowice.pl
Larysz-Brysz
Magdalena
M
Fus
Zbigniew
Z
Korczyńska
Izabela
I
Górka
Dariusz
D
Lewin-Kowalik
Joanna
J
D014408:Biomarkers, Tumor / Q000378:metabolism; D004796:Clinical Enzyme Tests; D018450:Disease Progression; D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology; D019636:Neurodegenerative Diseases / Q000201:enzymology; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor; D020782:Matrix Metalloproteinases