title: Influence of a new prophylactic antibiotic therapy on the incidence of liver abscesses after chemoembolization treatment of liver tumors.
abstract: Intrahepatic abscess is a complication of transcatheter arterial chemoembolization (TACE) treatment in patients who have a history of biliary reconstructive surgery. This study followed eight patients who underwent chemoembolization after biliary surgery. These patients were divided into two groups. Patients in group one (n = 4) were administered intravenous cephalexin for prophylaxis. Patients in group two (n = 4) were administered bowel preparation and tazobactam/piperacillin. All patients in group one developed hepatic abscesses, which were treated with percutaneous catheter drainage and antibiotics. None of the patients in group two developed abscesses. Aggressive antibiotic prophylaxis with bowel preparation may provide protection against intrahepatic abscesses after chemoembolization in patients who have a history of biliary reconstructive surgery.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA. jfg@jhmi.edu
authors.forename: Jean-Francois H
authors.initials: JF
authors.lastname: Geschwind
authors.forename: Shaifali
authors.initials: S
authors.lastname: Kaushik
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Ramsey
authors.forename: Michael A
authors.initials: MA
authors.lastname: Choti
authors.forename: Elliot K
authors.initials: EK
authors.lastname: Fishman
authors.forename: Hicham
authors.initials: H
authors.lastname: Kobeiter
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D019072:Antibiotic Prophylaxis; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000473:pathology; D002506:Cephalexin / Q000008:administration & dosage*; D016461:Chemoembolization, Therapeutic; D006801:Humans; D008100:Liver Abscess / Q000188:drug therapy*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000008:administration & dosage*; D012189:Retrospective Studies; D000078142:Tazobactam
chemical_list: D010397:Penicillanic Acid; D002506:Cephalexin; D000078142:Tazobactam; D010878:Piperacillin