title: Bilateral anterior optic neuritis in adult measles infection without encephalomyelitis.
abstract: OBJECTIVE
  To describe anterior optic neuritis in adult measles infection.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 31-year-old woman presented with bilateral visual loss 6 days after the onset of maculopapular rash. Complete ophthalmic and neurologic examinations, radiologic studies, and lumbar puncture were performed.
  
  
  RESULTS
  Visual acuities were counting fingers in both eyes, with bilateral optic disk hyperemia and swelling noted. Neurologic examination was unremarkable, and computed tomography and magnetic resonance imaging of the brain were normal. The cerebrospinal fluid (CSF) was devoid of white cells, although measles immunoglobulin M (IgM) antibodies were detected in both CSF and serum. Intravenous corticosteroids were administered, and clinical findings resolved within 1 month. A fall in serum IgM and a rise in serum IgG titers were observed.
  
  
  CONCLUSIONS
  Although rare, optic neuritis in the absence of encephalomyelitis may occur in measles. Whether treatment is effective is unknown.
authors.affiliation: Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Azuma
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Morimura
authors.forename: Sumie
authors.initials: S
authors.lastname: Kawahara
authors.forename: Annabelle A
authors.initials: AA
authors.lastname: Okada
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D004679:Encephalomyelitis / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008457:Measles / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008459:Measles virus / Q000276:immunology; D008775:Methylprednisolone / Q000627:therapeutic use; D009902:Optic Neuritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014792:Visual Acuity
chemical_list: D000914:Antibodies, Viral; D005938:Glucocorticoids; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008775:Methylprednisolone