Carcinogenicity of saccharin in laboratory animals and humans: letter to Dr. Harry Conacher of Health Canada.
We appreciate this opportunity to provide input to the Health Protection Branch's (HPB's) review of the artificial sweetener saccharin. Concerns with regard to the safety of saccharin are of great public health significance and of great interest to the public because saccharin is consumed by tens of millions of people, including children and fetuses. Any evidence of carcinogenesis--and there is ample such evidence--of such a widely used chemical should spur health officials to minimize human exposure to it. It is worth noting that on October 31, 1997, the Board of Scientific Counselors of the National Toxicology Program, a unit of the National Institute of Environmental Health Sciences (NIEHS), voted not to delist saccharin from its Report on Carcinogens.
Bell
Warren
W
Canadian Association of Physicians for the Environment, Salmon Arm, BC.
Clapp
Richard
R
Davis
Devra
D
Epstein
Samuel
S
Farber
Emmanuel
E
Fox
Donald A
DA
Holub
Bruce
B
Jacobson
Michael F
MF
Lijinsky
William
W
Millstone
Erik
E
Reuber
Melvin D
MD
Suzuki
David
D
Temple
Norman J
NJ
D000818:Animals; D015197:Carcinogenicity Tests; D003043:Cocarcinogenesis; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009153:Mutagens; D051381:Rats; D018570:Risk Assessment; D012439:Saccharin / Q000009:adverse effects / Q000633:toxicity*; D013549:Sweetening Agents / Q000009:adverse effects / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D009153:Mutagens; D013549:Sweetening Agents; D012439:Saccharin