An analysis of the pattern of pregnancy loss in women with recurrent miscarriage.
OBJECTIVE
To describe the pattern of pregnancy loss in women with a history of recurrent miscarriage (RM).


METHODS
Retrospective, observational study.


METHODS
A tertiary referral center for RM.


METHODS
Five hundred thirty-eight subjects with RM.


METHODS
Women with antiphospholipid syndrome were treated with clexane and aspirin; some patients with uterine anomalies underwent corrective surgery, and some cases of retarded endometrium were treated with hMG.


METHODS
Pregnancy outcome, including the stage of pregnancy at which pregnancy loss occurred.


RESULTS
In women with a prothrombotic state, the miscarriage rate before the detection of fetal heart activity (early loss) in the untreated group (50%) was significantly higher than in the treatment group (17.5%). In women with a uterine anomaly, the early loss rate and the later loss rate (after detection of fetal heart activity) were both increased. Women with retarded endometrium, women with >/=6 losses, and older women (>/=41 years) are more likely to have a further early loss but not a later loss.


CONCLUSIONS
An understanding of the patterns of pregnancy loss provides further insight into the mechanism of the reproductive failure, which has implications for treatment.
Li
Tin Chiu
TC
The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom. tin.li@sth.nhs.uk
Iqbal
Tanzeem
T
Anstie
Barbara
B
Gillham
Jo
J
Amer
Saad
S
Wood
Katherine
K
Laird
Susan
S
D000026:Abortion, Habitual / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D000328:Adult; D000375:Aging / Q000502:physiology; D015992:Body Mass Index; D005260:Female; D005318:Fetal Heart / Q000502:physiology; D006801:Humans; D015994:Incidence; D007246:Infertility / Q000150:complications; D007621:Karyotyping; D008423:Maternal Age; D008499:Medical Records; D008597:Menstrual Cycle; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors; D014591:Uterine Diseases / Q000150:complications