title: Hyperspectral techniques in analysis of oral dosage forms.
abstract: Pharmaceutical oral dosage forms are used in this paper to test the sensitivity and spatial resolution of hyperspectral imaging instruments. The first experiment tested the hypothesis that a near-infrared (IR) tunable diode-based remote sensing system is capable of monitoring degradation of hard gelatin capsules at a relatively long distance (0.5 km). Spectra from the capsules were used to differentiate among capsules exposed to an atmosphere containing 150 ppb formaldehyde for 0, 2, 4, and 8 h. Robust median-based principal component regression with Bayesian inference was employed for outlier detection. The second experiment tested the hypothesis that near-IR imaging spectrometry of tablets permits the identification and composition of multiple individual tablets to be determined simultaneously. A near-IR camera was used to collect thousands of spectra simultaneously from a field of blister-packaged tablets. The number of tablets that a typical near-IR camera can currently analyze simultaneously was estimated to be approximately 1300. The bootstrap error-adjusted single-sample technique chemometric-imaging algorithm was used to draw probability-density contour plots that revealed tablet composition. The single-capsule analysis provides an indication of how far apart the sample and instrumentation can be and still maintain adequate signal-to-noise ratio (S/N), while the multiple-tablet imaging experiment gives an indication of how many samples can be analyzed simultaneously while maintaining an adequate S/N and pixel coverage on each sample.
authors.affiliation: University of Kentucky, College of Pharmacy, Advanced Science and Technology Center, Lexington, Kentucky 40506-0286, USA.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Hamilton
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Lowell
authors.forename: Robert A
authors.initials: RA
authors.lastname: Lodder
mesh_terms: D000284:Administration, Oral; D002214:Capsules; D004304:Dosage Forms; D004340:Drug Contamination; D055095:Optics and Photonics / Q000295:instrumentation*; D019265:Spectroscopy, Near-Infrared; D013607:Tablets
chemical_list: D002214:Capsules; D004304:Dosage Forms; D013607:Tablets