title: Targeting and beyond: new roles for old signal sequences.
abstract: Signal sequences, once considered degenerate hydrophobic elements whose sole task is to target proteins to the secretory pathway, are increasingly being recognized as playing roles beyond targeting. Recent work is beginning to shed light on some of the ways the cell decodes and exploits additional functions encoded within signal sequences.
authors.affiliation: Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Ramanujan S
authors.initials: RS
authors.lastname: Hegde
mesh_terms: D016282:Aspartic Acid Endopeptidases / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D021382:Protein Sorting Signals / Q000502:physiology*; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D021382:Protein Sorting Signals; D011506:Proteins; D016282:Aspartic Acid Endopeptidases; C460085:signal peptide peptidase