title: Extracorporeal membrane oxygenator compatible with centrifugal blood pumps.
abstract: Coil-type silicone membrane oxygenators can only be used with roller blood pumps due to the resistance from the high blood flow. Therefore, during extracorporeal membrane oxygenation (ECMO) treatment, the combination of a roller pump and an oxygenator with a high blood flow resistance will induce severe hemolysis, which is a serious problem. A silicone rubber, hollow fiber membrane oxygenator that has a low blood flow resistance was developed and evaluated with centrifugal pumps. During in vitro tests, sufficient gas transfer was demonstrated with a blood flow less than 3 L/min. Blood flow resistance was 18 mm Hg at 1 L/min blood flow. This oxygenator module was combined with the Gyro C1E3 (Kyocera, Japan), and veno-arterial ECMO was established on a Dexter strain calf. An ex vivo experiment was performed for 3 days with stable gas performance and low blood flow resistance. The combination of this oxygenator and centrifugal pump may be advantageous to enhance biocompatibility and have less blood trauma characteristics.
authors.affiliation: Michael E DeBakey Department of Surgery, Artificial Organ Research Laboratory, Baylor College of Medicine, Houston, Texas 77030, USA. motomura@bcm.tmc.edu
authors.forename: Tadashi
authors.initials: T
authors.lastname: Motomura
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawahito
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsui
authors.forename: Seiji
authors.initials: S
authors.lastname: Ichikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishitoya
authors.forename: Masaki
authors.initials: M
authors.lastname: Kawamura
authors.forename: Ikuya
authors.initials: I
authors.lastname: Nishimura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Shinohara
authors.forename: Daniel
authors.initials: D
authors.lastname: Oestmann
authors.forename: Julia
authors.initials: J
authors.lastname: Glueck
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Koshiro
authors.initials: K
authors.lastname: Sato
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy*; D002417:Cattle; D002498:Centrifugation; D004195:Disease Models, Animal; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006353:Heart-Assist Devices; D066298:In Vitro Techniques; D010106:Oxygenators; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology