title: Squamous cell carcinoma in chronic lymphedema: case report and review of the literature.
abstract: BACKGROUND
  Squamous cell carcinoma (SCC) arising in chronic lymphedema is rare; only nine cases have been reported.
  
  
  OBJECTIVE
  To present the evolution of SCC in chronic lymphedema.
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  The tumor was treated by wide excision and covered by a skin graft.
  
  
  CONCLUSIONS
  In most of the other reported SCC cases in lymphedema, there are additional factors for carcinogenesis. There is no additional carcinogenic factor except for chronic lymphedema in our case. This strongly supports that lymphedema itself is one of the carcinogenic factors for not only angiosarcoma but also SCC.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Hokkaido University, School of Medicine, Sapporo, Japan. furufuru@beach.ocn.ne.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Minakawa
authors.forename: Tsuneki
authors.initials: T
authors.lastname: Sugihara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007866:Leg; D008209:Lymphedema / Q000150:complications*; D012878:Skin Neoplasms / Q000209:etiology* / Q000601:surgery