[Interaction of cationic surface-active antiseptics and serum albumin by the bacterial bioluminescence method].
Human serum albumin binding of cationic surface-active antiseptics was studied using a Photobacterium phosphoreum K3 strain isolated by the authors in the Black sea. Binding of cationic surface-active proteins to serum albumin led to disappearance of toxic and antibacterial characteristics of miramistine, ethonium, and decametoxin, but not chlorohexidine. The activity of chlorohexidine was reduced by 45-48% in the presence of albumin. Albumin binding capacity towards miramistine was 7.0-8.7%, towards ethonium 8.2-10%, and towards decametoxin 2.4-3%.
Katsev
A M
AM
Semenov
V Iu
VIu
D000891:Anti-Infective Agents, Local / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D002412:Cations; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008163:Luminescent Measurements; D010776:Photobacterium / Q000737:chemistry*; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013501:Surface-Active Agents / Q000737:chemistry* / Q000633:toxicity
D000891:Anti-Infective Agents, Local; D002412:Cations; D012709:Serum Albumin; D013501:Surface-Active Agents