title: Donor CMV serostatus has no impact on CMV viremia or disease when prophylactic granulocyte transfusions are given following allogeneic peripheral blood stem cell transplantation.
abstract: We studied the impact of donor cytomegalovirus (CMV) serologic status on CMV viremia and disease when prophylactic granulocyte colony-stimulating factor (G-CSF)-mobilized granulocyte transfusions (GTs) were given following allogeneic peripheral blood stem cell (AlloPBSC) transplantation. A cohort of 83 patients who received 2 prophylactic GTs from ABO-compatible stem cell donors following AlloPBSC transplantation was compared with a cohort of 142 patients who did not. AlloPBSC donors were eligible for granulocyte donation irrespective of their CMV serostatus. Recipients received no prophylactic therapy for CMV. Donor CMV serostatus had no impact on CMV viremia and disease in the 2 cohorts. Our data show that in an era of effective surveillance and preemptive therapy for CMV, AlloPBSC recipients can safely receive 2 transfusions of prophylactic G-CSF-mobilized granulocyte components from CMV-seropositive AlloPBSC donors. This knowledge may help expand the donor pool in areas with a high prevalence of CMV in the general population.
authors.affiliation: Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, St Louis, MO 63110-1093, USA. rvij@im.wustl.edu
authors.forename: Ravi
authors.initials: R
authors.lastname: Vij
authors.forename: John F
authors.initials: JF
authors.lastname: DiPersio
authors.forename: Partha
authors.initials: P
authors.lastname: Venkatraman
authors.forename: Kathryn
authors.initials: K
authors.lastname: Trinkaus
authors.forename: Lawrence T
authors.initials: LT
authors.lastname: Goodnough
authors.forename: Randy A
authors.initials: RA
authors.lastname: Brown
authors.forename: Hanna J
authors.initials: HJ
authors.lastname: Khoury
authors.forename: Steven M
authors.initials: SM
authors.lastname: Devine
authors.forename: Aarti
authors.initials: A
authors.lastname: Oza
authors.forename: Shalini
authors.initials: S
authors.lastname: Shenoy
authors.forename: William
authors.initials: W
authors.lastname: Blum
authors.forename: Douglas
authors.initials: D
authors.lastname: Adkins
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003587:Cytomegalovirus / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000635:transmission*; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006098:Granulocytes / Q000637:transplantation* / Q000821:virology; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D015994:Incidence; D017708:Leukocyte Transfusion / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D011446:Prospective Studies; D011897:Random Allocation; D012449:Safety; D014019:Tissue Donors; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D014766:Viremia / Q000453:epidemiology / Q000635:transmission*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor