Opinion: Interpretation of the complexity of innate immune responses by functional genomics.
Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.
Ricciardi-Castagnoli
Paola
P
Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy. paola.castgnoli@unimib.it
Granucci
Francesca
F
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D023281:Genomics; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007376:Interleukin-2 / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis
D007376:Interleukin-2; D008070:Lipopolysaccharides