Preparation of homoallylic alcohols by nickel-catalyzed cyclizations of allenyl aldehydes.
The direct cyclization of allenyl aldehydes with organozincs in the presence of Ni(COD)(2) provides synthetically versatile homoallylic alcohols. Both monosubstituted and 1,3-disubstituted allenes participate in the process, with the latter allowing preparation of stereochemically defined trisubstituted alkenes. [reaction: see text]
Montgomery
John
J
Department of Chemistry, Wayne State University, Detroit, MI 48202-3489, USA. jwm@chem.wayne.edu
Song
Minsoo
M
D000438:Alcohols / Q000138:chemical synthesis*; D000447:Aldehydes / Q000737:chemistry*; D000498:Allyl Compounds; D002384:Catalysis; D007202:Indicators and Reagents; D009532:Nickel
D000438:Alcohols; D000447:Aldehydes; D000498:Allyl Compounds; D007202:Indicators and Reagents; D009532:Nickel