title: Effect of cadmium on sciatic nerve in diabetic rats: an ultrastructural study.
abstract: The present study demonstrated the ultrastructural effects of diabetes and cadmium on the peripheral nervous system. In this study we used 52 healthy Swiss male albino rats. They were divided into four groups: control (C), diabetic (D), cadmium (Cd), and diabetic and cadmium (D + Cd). The diabetic condition was induced by intravenous injection of 5 mg alloxan/100 g body weight, via the caudal vein. Cd and D + Cd groups were injected with CdCl2 intraperitoneally (2 mg/Kg/week) for two months. At the end of the experimental period, animals were sacrificed and their sciatic nerves were dissected. The tissue samples were investigated by using light and electron microscopic techniques. Upon investigation, it was seen that myelinated axons in sciatic nerve of diabetic and Cd treatment groups had onion-bulb type myelin destruction, melting, and protrusion. Basal lamina of capillary endothelia of D, Cd, and D + Cd groups were thickened and the endothelial apical membrane was rough. In conclusion, Cd toxicity exacerbated the destructive effect of diabetes on the peripheral nervous system.
authors.affiliation: Department of Histology and Embryology, Akdeniz University, Faculty of Medicine, School of Medicine, 07070, Antalya, Turkey. necdet@med.akdeniz.edu.tr
authors.forename: Necdet
authors.initials: N
authors.lastname: Demir
authors.forename: Gokhan
authors.initials: G
authors.lastname: Akkoyunlu
authors.forename: Aysel
authors.initials: A
authors.lastname: Agar
authors.forename: Piraye
authors.initials: P
authors.lastname: Yargicoglu
authors.forename: Gamze
authors.initials: G
authors.lastname: Tanriover
authors.forename: Ramazan
authors.initials: R
authors.lastname: Demir
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure
chemical_list: D002104:Cadmium