The relationship between nonresponse to hepatitis B vaccine and HLA genotype/haplotype.
OBJECTIVE
To study the relationship between the nonresponse to hepatitis B vaccine and HLA genotype/heplotype in Chinese population and provide the evidence for explaining the genetic mechanism of this nonresponse.


METHODS
Our research focused on the relationship between nonresponse to Hepatitis B vaccine and HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 genotype/haplotype in Chinese population, collected from a community in Guangxi Zhuang Autonomous Region. The group specific amplification was employed to characterize 107 individuals' genotype and haplotype of HLA clusters. Different models statistics such as relative risk test, correlation test and linkage disequilibrium analysis were used to analyze the data.


RESULTS
The results showed that there is a linkage disequilibrium between nonresponse to Hepatitis B vaccine and HLA haplotype DR4, 1122 (DRB1 * 0401- 22, 1122)-DR53 (DRB4 * 0101101, 0102/3)-DQB4 (DQB1 * 04).


CONCLUSIONS
In Chinese population, nonresponse to hepatitis B vaccine is highly associated with special HLA haplotye.
Li
Mingyue
M
Department of Epidemiology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.
Li
Rongcheng
R
Huang
Shangzhi
S
Gong
Jian
J
Zeng
Xianjia
X
Li
Yanping
Y
Lu
Ming
M
Li
Hui
H
D044466:Asian People / Q000235:genetics*; D002681:China; D005838:Genotype; D006683:HLA-DQ Antigens / Q000145:classification / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D059845:HLA-DRB4 Chains; D059847:HLA-DRB5 Chains; D006239:Haplotypes; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D015810:Linkage Disequilibrium
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553505:HLA-DRB1*04:01 antigen; D059826:HLA-DRB3 Chains; D059845:HLA-DRB4 Chains; D059847:HLA-DRB5 Chains; D017325:Hepatitis B Vaccines