Clinical features and comorbidity of mood fluctuations in Parkinson's disease.
Parkinson's disease (PD) patients commonly develop fluctuations in their motor responses to levodopa within several years of initiation of treatment; some also develop nonmotor fluctuations. The authors performed a case-control study comparing the frequency of comorbid symptoms in 70 PD patients who experienced clinically apparent mood changes during their motor "on" or "off" states with two control groups with no mood fluctuations. Mood fluctuators had significantly younger age at onset and longer disease duration and were significantly more likely to have dementia, psychosis, clinical depression, and motor complications. This association remained after removing effects of age and disease duration.
Racette
Brad A
BA
Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA. racetteb@neuro.wustl.edu
Hartlein
Johanna M
JM
Hershey
Tamara
T
Mink
Jonathan W
JW
Perlmutter
Joel S
JS
Black
Kevin J
KJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D010300:Parkinson Disease / Q000453:epidemiology / Q000523:psychology; D012720:Severity of Illness Index; D014202:Tremor / Q000453:epidemiology