title: Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph+ adult acute lymphoblastic leukaemia.
abstract: We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resulting from this novel translocation, and its possible role in the progression of the leukaemia is discussed.
authors.affiliation: Department of Haematology, University of Bari, Italy. emadhba@cimedoc.uniba.it
authors.forename: Giorgina
authors.initials: G
authors.lastname: Specchia
authors.forename: Francesco
authors.initials: F
authors.lastname: Albano
authors.forename: Luisa
authors.initials: L
authors.lastname: Anelli
authors.forename: Clelia Tiziana
authors.initials: CT
authors.lastname: Storlazzi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cimino
authors.forename: Arcangelo
authors.initials: A
authors.lastname: Liso
authors.forename: Antonella
authors.initials: A
authors.lastname: Zagaria
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Liso
authors.forename: Mariano
authors.initials: M
authors.lastname: Rocchi
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D014178:Translocation, Genetic