title: [Pharmacokinetics of ethyl alcohol and its importance for forensic calculations of blood alcohol levels].
abstract: Calculations of blood alcohol concentration for forensic purposes are based on several simplified assumptions (linear pharmacokinetics of ethanol, constant rate of ethanol elimination within full range of time, constant rate of alcohol absorption and constant time of peak blood alcohol levels achievement which is by convention depending only on type of a beverage and quantity of food consumed). Simplified and idealized assumptions mentioned above significantly restrict possibility of back-extrapolations of blood alcohol concentrations from the observed values and calculations based on them exclude the absorption phase of blood alcohol curve from being estimated. In this work there are designs of more advanced models of alcohol pharmacokinetics describing blood alcohol concentrations within full ranges of blood alcohol curves. Their possible benefits for forensic medicine and practical aspects are discussed.
authors.affiliation: rozmez@pobox.sk
authors.forename: R
authors.initials: R
authors.lastname: Mezencev
authors.forename: J
authors.initials: J
authors.lastname: Kyska
mesh_terms: D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood / Q000175:diagnosis; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D005554:Forensic Medicine; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000431:Ethanol