title: Stability of cefepime dihydrochloride monohydrate in solid state.
abstract: The pseudo first-order rate constants and thermodynamic parameters for the decomposition of cefepime in solid state in absence of humidity and at a relative humidity of 76.4% were calculated. The effect of humidity on the stability of cefepime dihydrochloride monohydrate in the humidity range 25.0%-76.4% at 358 K is described by the equation ln ki = (0.031 +/- 0.0043) x RH% - 10.08 +/- 0.22.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Karol Marcinkowski Medical University, Poznań, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Musiał
authors.forename: Marianna
authors.initials: M
authors.lastname: Zajac
mesh_terms: D000077723:Cefepime; D002511:Cephalosporins / Q000737:chemistry* / Q000493:pharmacokinetics*; D004355:Drug Stability
chemical_list: D002511:Cephalosporins; D000077723:Cefepime