title: Association analysis between the human interleukin 1beta (-511) gene polymorphism and susceptibility to febrile convulsions.
abstract: Recently, an association between a regulatory polymorphism in the gene encoding the pro-inflammatory cytokine interleukin (IL)-1beta and febrile convulsions (FC) has been reported. In this study we attempted to confirm these findings in a sample consisting of 99 FC patients and 126 ethnically matched controls. Since about 3% of all FC patients experience unprovoked seizures (epilepsy) later during life we furthermore genotyped 43 patients with non-lesional temporal lobe epilepsy who reported a history of FC. In both samples we failed to show an association between the IL-1beta polymorphism and an increased risk for FC. We only found a trend towards an increased frequency and carriage of the putative IL-1beta susceptibility allele two in a sub-sample of 43 FC patients who reported a positive family history for seizures in first and/or second degree relatives. However, these trends did not reach statistical significance.
authors.affiliation: University Department of Human Genetics, Wilhelmstrasse 31, 53111 Bonn, Germany.
authors.forename: Nikola
authors.initials: N
authors.lastname: Tilgen
authors.forename: Heike
authors.initials: H
authors.lastname: Pfeiffer
authors.forename: Joana
authors.initials: J
authors.lastname: Cobilanschi
authors.forename: Birgit
authors.initials: B
authors.lastname: Rau
authors.forename: Steve
authors.initials: S
authors.lastname: Horvath
authors.forename: Christian E
authors.initials: CE
authors.lastname: Elger
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: Armin
authors.initials: A
authors.lastname: Heils
mesh_terms: D004198:Disease Susceptibility; D004833:Epilepsy, Temporal Lobe / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D003294:Seizures, Febrile / Q000235:genetics*
chemical_list: D007375:Interleukin-1