title: CNS demyelination associated with copper deficiency and hyperzincemia.
abstract: CNS demyelination is not a previously reported feature of acquired copper deficiency. The authors report two patients with idiopathic hypocupremia and hyperzincemia, hematologic changes of copper deficiency, and extensive CNS demyelination. Hematologic recovery followed copper supplementation, both initially and after relapse off copper therapy, while serum zinc levels remained high and the neurologic abnormalities only stabilized.
authors.affiliation: Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. calin-prodan@ouhsc.edu
authors.forename: C I
authors.initials: CI
authors.lastname: Prodan
authors.forename: N R
authors.initials: NR
authors.lastname: Holland
authors.forename: P J
authors.initials: PJ
authors.lastname: Wisdom
authors.forename: S A
authors.initials: SA
authors.lastname: Burstein
authors.forename: S S
authors.initials: SS
authors.lastname: Bottomley
mesh_terms: D001921:Brain / Q000473:pathology; D003300:Copper / Q000172:deficiency*; D003711:Demyelinating Diseases / Q000097:blood* / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015032:Zinc / Q000097:blood*
chemical_list: D003300:Copper; D015032:Zinc