title: Chlamydial heat-shock protein-60 antibody and correlation with Chlamydia pneumoniae in atherosclerotic plaques.
abstract: A study was performed to determine whether serum antibody to Chlamydial heat-shock protein-60 (CHSP-60) and C-reactive protein (CRP) were associated with the presence of Chlamydia pneumoniae in atheromatous plaques in 75 patients. The mean (+/-SD) ELISA optical density (OD) of anti-CHSP-60 was 0.19+/-0.15 in 54 patients with detectable C. pneumoniae antigen, versus an OD of 0.11+/-0.08 in 21 patients without detectable C. pneumoniae I antigen (P=.008). Higher anti-CHSP-60 at an OD > or =0.12 was present in 38 (70.4%) of patients with detectable C. pneumoniae in atheromas, compared with 5 (23.8%) of patients without C. pneumoniae antigen (P<.001; 2-tailed test). The mean CRP concentration was 7.4+/-10.3 mg/L in patients with detectable C. pneumoniae antigen, versus 5.7+/-6.1 mg/L in those without (P=.556). Immune response to CHSP-60 may play a role in atherogenesis, but CRP serum levels does not appear to be related to C. pneumoniae infection.
authors.affiliation: Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. fongi@smh.toronto.on.ca
authors.forename: Ignatius W
authors.initials: IW
authors.lastname: Fong
authors.forename: Brian
authors.initials: B
authors.lastname: Chiu
authors.forename: Esther
authors.initials: E
authors.lastname: Viira
authors.forename: William
authors.initials: W
authors.lastname: Tucker
authors.forename: Heidi
authors.initials: H
authors.lastname: Wood
authors.forename: Rosanna W
authors.initials: RW
authors.lastname: Peeling
mesh_terms: D000906:Antibodies / Q000032:analysis*; D000942:Antigens, Bacterial / Q000032:analysis* / Q000276:immunology; D001161:Arteriosclerosis / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D018834:Chaperonin 60 / Q000032:analysis* / Q000276:immunology; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D013223:Statistics as Topic
chemical_list: D000906:Antibodies; D000942:Antigens, Bacterial; D018834:Chaperonin 60