Results of thyroid function tests and concentrations of plasma proteins in dogs administered etodolac.
OBJECTIVE
To determine the effects of etodolac administration on results of thyroid function tests and concentrations of plasma proteins in clinically normal dogs.


METHODS
19 healthy random-source mixed-breed dogs.


METHODS
Blood samples for measurement of serum thyroxine (T4), 3,5,3'-triiodothyronine (T3), free T4 (fT4), and endogenous canine thyroid stimulating hormone (cTSH) were measured twice before as well as on days 14 and 28 of etodolac administration (mean dosage, 13.7 mg/kg, PO, q 24 h). Plasma total protein, albumin, and globulin concentrations and serum osmolality were measured once before as well as on days 14 and 28 of etodolac administration.


RESULTS
Etodolac administration did not significantly affect serum T4, T3, fT4, or cTSH concentrations or serum osmolality. Significant decreases in plasma total protein, albumin, and globulin concentrations were detected on days 14 and 28 of administration.


CONCLUSIONS
Results of thyroid function tests are not altered when etodolac is administered for up to 4 weeks. Therefore, interpretation of results of these tests should accurately reflect thyroid function during etodolac treatment. Plasma total protein, albumin, or globulin concentrations that are less than the respective reference range in a dog administered etodolac for > or = 2 weeks may be an effect of treatment rather than an unrelated disease process. A decrease in plasma protein concentrations may reflect subclinical injury of the gastrointestinal tract.
Panciera
David L
DL
Johnston
Spencer A
SA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology*; D001798:Blood Proteins / Q000032:analysis; D004285:Dogs / Q000097:blood / Q000502:physiology*; D017308:Etodolac / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D008297:Male; D009994:Osmolar Concentration; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001798:Blood Proteins; D012709:Serum Albumin; D012712:Serum Globulins; D014284:Triiodothyronine; D017308:Etodolac; D013972:Thyrotropin; D013974:Thyroxine