title: Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones.
abstract: A series of novel 2-phenyl-3-substituted quinazolin-4(3H)-ones have been synthesized by treating methyl-N-(2-phenyl quinazolin-3-yl-4(3H)-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds A1, A2 and A3 shown more potent analgesic activity, and the compound A3 shown more potent anti-inflammatory activity than the reference standard diclofenac sodium.
authors.affiliation: Medicinal Chemistry Laboratory, SB College of Pharmacy, Sivakasi, India. samy_veera@yahoo.com
authors.forename: Veerachamy
authors.initials: V
authors.lastname: Alagarsamy
authors.forename: Viswas Raja
authors.initials: VR
authors.lastname: Salomon
authors.forename: Gnanavel
authors.initials: G
authors.lastname: Vanikavitha
authors.forename: Veeran
authors.initials: V
authors.lastname: Paluchamy
authors.forename: Muniyandi Ravi
authors.initials: MR
authors.lastname: Chandran
authors.forename: Augustin Arnald
authors.initials: AA
authors.lastname: Sujin
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Thangathiruppathy
authors.forename: Sivaperuman
authors.initials: S
authors.lastname: Amuthalakshmi
authors.forename: Rajappan
authors.initials: R
authors.lastname: Revathi
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines