title: Neuropsychiatric features of frontotemporal dementia: evaluation of consensus criteria and review.
abstract: Neuropsychiatric features characterize frontotemporal dementia (FTD). The authors evaluated the neuropsychiatric features of 53 FTD patients and retrospectively applied the Consensus Criteria for this disorder. Only one-third of the patients met Consensus Criteria for FTD on presentation. Most had early disengagement with poor insight; however, more than half retained socially appropriate interpersonal conduct and emotional expression. Supportive features, including compulsive-like acts and speech changes, were common presenting features, and 20% developed the Klüver-Bucy syndrome on 2-year follow-up. Consensus Criteria for FTD offer guidelines for diagnosis, but further refinement is needed, particularly for patients who lack early changes in social interpersonal conduct.
authors.affiliation: Department of Neurology, UCLA School of Medicine, Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. mmendez@UCLA.edu
authors.forename: Mario F
authors.initials: MF
authors.lastname: Mendez
authors.forename: Kent M
authors.initials: KM
authors.lastname: Perryman
mesh_terms: D003192:Compulsive Behavior / Q000175:diagnosis / Q000209:etiology; D032921:Consensus; D003704:Dementia / Q000150:complications* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007398:Interpersonal Relations; D020232:Kluver-Bucy Syndrome / Q000209:etiology; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000473:pathology*