Biological correlates of clinical subgroups of Alzheimer's disease.
We considered it possible that the differences in clinical symptoms between two suggested subgroups of Alzheimer's disease (AD), AD type I and AD type II, have biological correlates, for instance different metabolic profiles. Therefore, we performed regional cerebral blood flow (rCBF) measurements and investigated the cerebrospinal fluid (CSF) levels of the monoamine metabolites homovanillic acid (HVA), 5-HIAA, and HMPG in 15 patients with AD type I, in 36 patients with AD type II, in a control group and in a contrast group consisting of 16 patients with frontotemporal dementia. The results suggest that there are underlying biological correlates of the phenomenological discrepancies between AD type I and AD type II. For instance, a decreased CSF level of HVA (p < 0.001) was specific to AD type I and decreased rCBF (p < 0.05 to <0.001) in three particular regions was specific to AD type II.
Sjögren
Magnus
M
Institute of Clinical Neuroscience, Göteborg University, Göteborg, Sweden. magnus.sjogren@medfak.gu.se
Wikkelsö
Carsten
C
Ostling
Svante
S
Wallin
Anders
A
Blennow
Kaj
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000145:classification* / Q000503:physiopathology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000098:blood supply*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000098:blood supply; D011569:Psychiatric Status Rating Scales; D011624:Pteroylpolyglutamic Acids / Q000134:cerebrospinal fluid; D013702:Temporal Lobe / Q000098:blood supply; D015899:Tomography, Emission-Computed, Single-Photon
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015415:Biomarkers; D011624:Pteroylpolyglutamic Acids; C052093:7-hydro-8-methylpteroylglutamylglutamic acid; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid