Cytogenetics and molecular genetics of cancer of the prostate.
Prostate cancer remains the most common male malignancy in Western countries and the second-leading cause of death from cancer in males. Progress in the understanding of molecular and genetic mechanisms leading to this disease has only recently begun to offer a glimpse of the genes, chromosomal sites, and proteins implicated in the development and progression of prostate tumors. This brief review addresses some of the key issues in prostate cancer research, including a discussion of both hereditary and sporadic cancers as well as specific genes and chromosomal loci that likely play a part in the etiology of this disease.
Brothman
Arthur R
AR
University of Utah, School of Medicine, Salt Lake City 84132, USA. art.brothman@genetics.utah.edu
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000172:deficiency / Q000235:genetics; D000818:Animals; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase