Treatment of tendopathies with tropisetron.
A comparison between a local anesthetic drug and the 5-hydroxytryptamine 3 (5-HT3) receptor antagonist tropisetron in treating tendopathies or periarthropathies revealed that tropisetron has a longer effect on resting pain and pain on movement than the local anesthetic drug. The most likely explanation for this effect probably is a blocking of stimulated 5-HT3 receptors at the nociceptors in conjunction with an inhibited release of substance P and other neurokines because of this blockage. Further studies will have to show whether the action of tropisetron in tendopathies is as favorable as that of corticosteroids.
Stratz
Thomas
T
Hochrhein-Institut für Rehabilitationsforschung, Bergseestrasse 61, 79713 Bad Säckingen, Germany.
Varga
Boglarka
B
Müller
Wolfgang
W
D000779:Anesthetics, Local; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000627:therapeutic use*; D036502:Infusions, Intralesional; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D009068:Movement; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D010147:Pain Measurement; D011318:Prilocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D052256:Tendinopathy / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D000077526:Tropisetron
D000779:Anesthetics, Local; D007211:Indoles; D012702:Serotonin Antagonists; D011318:Prilocaine; D000077526:Tropisetron