Fracture prevalence in Duchenne muscular dystrophy.
The objective of this study was to determine the prevalence, circumstances, and outcome of fractures in males with Duchenne muscular dystrophy (DMD) attending neuromuscular clinics. Three hundred and seventy-eight males (median age 12 years, range 1 to 25 years) attending four neuromuscular centres were studied by case-note review supplemented by GP letter or by interview at the time of clinic attendance. Seventy-nine (20.9%) of these patients had experienced fractures. Forty-one percent of fractures were in patients aged 8 to 11 years and 48% in independently ambulant patients. Falling was the most common mechanism of fracture. Upper-limb fractures were most common in males using knee-ankle-foot orthoses (65%) while lower-limb fractures predominated in independently mobile and wheelchair dependent males (54% and 68% respectively). Twenty percent of ambulant males and 27% of those using orthoses lost mobility permanently as a result of the fracture. In a substantial proportion of males, the occurrence of a fracture had a significant impact on subsequent mobility.
McDonald
Denise G M
DG
Oxford Radcliffe NHS Trust, UK.
Kinali
Maria
M
Gallagher
Andrew C
AC
Mercuri
Eugenio
E
Muntoni
Francesco
F
Roper
Helen
H
Jardine
Philip
P
Jones
David Hilton
DH
Pike
M G
MG
D000203:Activities of Daily Living / Q000145:classification; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D050723:Fractures, Bone / Q000453:epidemiology* / Q000209:etiology / Q000534:rehabilitation; D006801:Humans; D007223:Infant; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000150:complications / Q000453:epidemiology* / Q000534:rehabilitation; D009989:Orthotic Devices; D012307:Risk Factors; D014910:Wheelchairs