A case of hypersensitivity syndrome due to phenytoin.
We report a 30-year-old female with hypersensitivity syndrome (HS) due to phenytoin. Her disease course was typical with elevation of the antibody titer for human herpes virus 6. Three courses of methylpredonisolone pulse therapy were required to control the disease activity. Since the pathogenic mechanism and treatments for HS have not been established, further clinical analyses are warranted.
Nagai
Yayoi
Y
Department of Dermatology, Tone Central Hospital, Numata, Gunma, Japan.
Hattori
Tomoyasu
T
Ishikawa
Osamu
O
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D010672:Phenytoin / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D013577:Syndrome
D000927:Anticonvulsants; D005938:Glucocorticoids; D010672:Phenytoin; D008775:Methylprednisolone