title: [Encephalitis caused by Rickettsia conorii without exanthema].
abstract: BACKGROUND
  Mediterranean boutonneuse fever, caused by Rickettsia conorii, is an endemic disease in the Mediterranean area. The serious forms of the disease, which include encephalitis, are infrequent but are associated with a high mortality rate. Diagnostic suspicion is backed up by the development of exanthema. We report the case of a patient who developed encephalitis caused by Rickettsia conorii without exanthema. Clinical case. A 27 year old woman who had nauseas, headache, fever, abdominal upset and generalised pain during the days before being admitted to hospital. On the day she was admitted, she noticed reduced strength in the left limbs, together with numbness and pins and needles in the left side of the body. In the casualty department she presented tonic seizures in the left extremities and later generalised tonic clonic seizures. Exploration showed facial paresis and 4/5 hemiparesis on the left side. Complementary tests carried out in casualty, including cerebrospinal fluid (CSF), did not reveal any significant findings. She was admitted after a loading dose of phenytoin. After 48 hours she presented fever and repeated complex partial seizures. A new CSF analysis was normal. She was treated with valproate, clonazepam, ceftriaxone, doxycycline and acyclovir. An electroencephalogram (EEG) showed theta activity in the left centroparietal areas and slow delta waves in the right temporal regions. Magnetic resonance imaging (MRI) of the brain showed contrast enhancement in the meninges. 24 later, due to the frequency of the seizures, phenobarbital and methylprednisolone were added, which enabled the seizures to be controlled. The posterior brain MRI revealed a right parasylvian lesion. Serological Rickettsia conorii IgM +, IgG 1/256 was administered. After eight months, she has presented no seizures or neurological deficit.
  
  
  CONCLUSIONS
  There are cases of encephalitis from Rickettsia conorii that can present without exanthema. This means that in endemic areas early treatment with doxycycline could be advisable when faced with encephalitis of unknown aetiology, bearing in mind the high mortality rate that occurs when no early treatment is administered and the good tolerance to doxycycline.
authors.affiliation: Hospital General Universitario de Valencia, Valencia, España.
authors.forename: J
authors.initials: J
authors.lastname: Parra-Martínez
authors.forename: J
authors.initials: J
authors.lastname: Sancho-Rieger
authors.forename: P
authors.initials: P
authors.lastname: Ortiz-Sánchez
authors.forename: V
authors.initials: V
authors.lastname: Peset
authors.forename: A
authors.initials: A
authors.lastname: Brocalero
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: J
authors.initials: J
authors.lastname: López-Trigo
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000927:Anticonvulsants / Q000627:therapeutic use; D001907:Boutonneuse Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002443:Ceftriaxone / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004569:Electroencephalography; D004660:Encephalitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D005158:Facial Paralysis / Q000209:etiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008279:Magnetic Resonance Imaging; D010291:Paresis / Q000209:etiology; D020114:Rickettsia conorii / Q000276:immunology / Q000472:pathogenicity*; D012640:Seizures / Q000188:drug therapy / Q000209:etiology
chemical_list: D000907:Antibodies, Bacterial; D000927:Anticonvulsants; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002443:Ceftriaxone; D004318:Doxycycline; D000212:Acyclovir