The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns.
Because there is no ideal therapy for burns infected with Pseudomonas aeruginosa, there is sufficient need to investigate the efficacy of alternative antipseudomonal interventions. Honey is an ancient wound remedy for which there is modern evidence of efficacy in the treatment of burn wounds, but limited evidence for the effectiveness of its antibacterial activity against Pseudomonas. We tested the sensitivity of 17 strains of P. aeruginosa isolated from infected burns to two honeys with different types of antibacterial activity, a pasture honey and a manuka honey, both with median levels of activity. All strains showed similar sensitivity to honey with minimum inhibitory concentrations below 10% (vol/vol); both honeys maintained bactericidal activity when diluted more than 10-fold. Honey with proven antibacterial activity has the potential to be an effective treatment option for burns infected or at risk of infection with P. aeruginosa.
Cooper
R A
RA
Centre for Biomedical Sciences, School of Applied Sciences, University of Wales Institute, Cardiff, Wales, United Kingdom.
Halas
E
E
Molan
P C
PC
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002056:Burns / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial; D006722:Honey; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D014946:Wound Infection / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents