Autoimmune hemolytic anemia in Philadelphia positive chronic myeloid leukemia with t(7;14) anomaly after 5 years of interferon alpha treatment.
A 41-year-old woman, Philadelphia positive chronic myeloid leukemia patient, had progressive decline in hemoglobin levels. She had been receiving interferon alpha treatment for five years. Autoimmune hemolytic anemia was diagnosed. Subsequent bone marrow examination revealed translocation t(7;14). She was placed on prednisone treatment. The patient responded to prednisone as treatment for the hemolytic process. The result of a direct Coombs' test remained positive. The patient died shortly after the diagnosis of autoimmune hemolytic anemia. Autoimmune hemolytic anemia should be considered in the evaluation of chronic myeloid leukemia patients with a sudden decrease in hemoglobin levels.
Köksal
Aydin
A
Kirikkale University Medical School, Department of Internal Medicine, Turkey. dckoksal@hotmail.com
Ozatli
Düzgün
D
Haznedaroğlu
Ibrahim C
IC
Sunguroğlu
Asuman
A
Karakuş
Sema
S
Büyükaşik
Yahya
Y
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000209:etiology*; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D014178:Translocation, Genetic
D016898:Interferon-alpha