Analytical studies on two amino acid derivatives of anticonvulsant activity.
Qualitative and quantitative methods of analysis of two new amino acid derivatives, potential anticonvulsants of low neurotoxicity: N-acetyl-gamma-aminobutyric acid benzylamide (1) and N-melhyl-gamma-aminobutyric acid benzylamide (2) were developed. Qualitative analysis includes characteristic colour reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation and quantitative analysis involves spectrophotometric, chromatographic (HPLC). acidimetric and argentomeric methods.
Pirianowicz-Chaber
Elzbieta
E
Department of Drug Chemistry, The Medical University of Warsaw, Poland.
Paruszewski
Ryszard
R
D000596:Amino Acids / Q000032:analysis* / Q000737:chemistry; D000927:Anticonvulsants / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000706:statistics & numerical data; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000737:chemistry
D000596:Amino Acids; D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid