Analysis of the coxsackievirus B-adenovirus receptor gene in patients with myocarditis or dilated cardiomyopathy.
Myocarditis and dilated cardiomyopathy (DCM) are common causes of morbidity and mortality in children and adults, most commonly due to infection with coxsackievirus B or adenovirus. Increased expression of the common human coxsackievirus B-adenovirus receptor (CAR) has been reported in patients with DCM. We investigated the CAR gene in patients with acquired or familial myocarditis/DCM for mutations/polymorphisms. Several polymorphisms or intronic substitutions, distant from the intron-exon boundaries, were identified but no mutations. Based upon these data it appears that CAR gene mutations are not a major host determinant in the development of myocarditis and DCM.
Bowles
Neil E
NE
Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, One Baylor Plaza, Room 333E, , Houston, TX 77030-3411, USA. nbowles@bcm.tmc.edu
Javier Fuentes-Garcia
F
F
Makar
Kimberly A
KA
Li
Hua
H
Gibson
Jason
J
Soto
Feiris
F
Schwimmbeck
Peter L
PL
Schultheiss
Heinz Peter
HP
Pauschinger
Matthias
M
D000256:Adenoviridae / Q000235:genetics; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D002851:Chromatography, High Pressure Liquid; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D004770:Enterovirus / Q000235:genetics; D006801:Humans; D009205:Myocarditis / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D011991:Receptors, Virus / Q000235:genetics*
C568771:CLMP protein, human; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus