Pneumatosis intestinalis associated with immune-suppressive agents in a case of minimal change disease.
We report treatment of a 38-year-old man with minimal change disease (MCD) who developed pneumatosis intestinalis (PI) during administration of immune-suppressive agents. His immunosuppressive medication had been tapered to 15 mg/day of prednisolone. MCD was steroid-resistant type. Abdominal examination and laboratory studies were not clinically remarkable. Radiologic findings were consistent with PI. Abnormal air accumulation was noted in the bowel, peritoneum, mediastinum and retroperitoneum. Conservative therapy with oxygen and metronidazole improved the PI symptoms. In 1993, a case of PI with nephrotic syndrome following steroid treatment was reported in Japan. However this is only the second case reported in the literature, and the first in English.
Han
Byoung Geun
BG
Department of Nephrology, Yonsei University Wonju College of Medicine, Korea.
Lee
Jae Myoung
JM
Yang
Jae Won
JW
Kim
Min Soo
MS
Choi
Seung Ok
SO
D000328:Adult; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D009402:Nephrosis, Lipoid / Q000188:drug therapy*; D011006:Pneumatosis Cystoides Intestinalis / Q000139:chemically induced*; D011239:Prednisolone / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D011239:Prednisolone