DNA minor groove hydration probed with 4'-alkylated thymidines.
Employing modified oligonucleotides that are 4'-alkylated site-specifically we investigated the involvement of DNA minor groove hydration on DNA duplex stability and helix conformation.
Detmer
Ilka
I
Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.
Summerer
Daniel
D
Marx
Andreas
A
D000478:Alkylation; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature; D013936:Thymidine; D014867:Water / Q000737:chemistry*
D015335:Molecular Probes; D009841:Oligonucleotides; D014867:Water; D004247:DNA; D013936:Thymidine