Current options for the treatment of neoplastic meningitis.
Neoplastic meningitis, which is the diffuse involvement of the leptomeninges by infiltrating cancer cells, may be caused by many systemic tumors. The treatment options for neoplastic meningitis disease remain unsatisfactory. In this review article, we discuss the pathogenesis and cytology of neoplastic meningitis and the options for treatment, including intrathecal chemotherapy, systemic chemotherapy, and newer agents such as cytokines and monoclonal antibodies.
Cokgor
Ilkcan
I
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Friedman
Allan H
AH
Friedman
Henry S
HS
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D004358:Drug Therapy; D006801:Humans; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D008581:Meningitis / Q000175:diagnosis / Q000188:drug therapy*
D000970:Antineoplastic Agents