title: Marked (24-fold) elevation of peritoneal cavity drainage fluid vascular endothelial growth factor after successful "patch, drain, and wait" approach for extensive midgut necrosis in a newborn.
abstract: In a current publications, it has been suggested that hypoxia-triggered "good angiogenesis" involving hypoxic up-regulation of vascular endothelial growth factor (VEGF) molecules, genes, and receptors is likely responsible in a major way for the remarkable gut and patient salvage experience associated with use of the "patch, drain, and wait" (PD&W) surgical approach to perforated necrotizing enterocolitis and midgut volvulus (MGV) with extensive ischemia/necrosis. We report a case in which extensive ischemia/necrosis in a newborn with gastroschisis (likely MGV-induced) was managed successfully by PD&W with an associated marked (24-fold) elevation of VEGF in drainage fluid at 7 days post-initiation of PD&W.
authors.affiliation: Division of Pediatric Surgery, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Moore
authors.forename: David L
authors.initials: DL
authors.lastname: Collins
authors.forename: Mai
authors.initials: M
authors.lastname: Nguyen
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D013505:Digestive System Surgical Procedures; D004322:Drainage; D016228:Endothelial Growth Factors / Q000032:analysis* / Q000502:physiology; D020345:Enterocolitis, Necrotizing / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000601:surgery*; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis* / Q000502:physiology; D007415:Intestinal Obstruction / Q000503:physiopathology / Q000601:surgery; D007416:Intestinal Perforation / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D008222:Lymphokines / Q000032:analysis* / Q000502:physiology; D008297:Male; D018919:Neovascularization, Physiologic; D010529:Peritoneal Cavity; D013526:Surgical Mesh; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors