title: Two-pore domain K+ channels-molecular sensors.
abstract: Two-pore domain K(+) (K2P) channels have been cloned from a variety of species and tissues. They have been characterised biophysically as a 'background' K(+)-selective conductance and are gated by pH, stretch, heat, coupling to G-proteins and anaesthetics. Whilst their precise physiological function is unknown, they are likely to represent an increasingly important family of membrane proteins.
authors.affiliation: Worsley Medical and Dental Building, School of Biomedical Sciences, University of Leeds, Leeds, UK.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: O'Connell
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Morton
authors.forename: Malcolm
authors.initials: M
authors.lastname: Hunter
mesh_terms: D000595:Amino Acid Sequence; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D015374:Biosensing Techniques; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry; D003001:Cloning, Molecular; D004553:Electric Conductivity; D006321:Heart / Q000187:drug effects; D006801:Humans; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D009206:Myocardium / Q000737:chemistry; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000187:drug effects; D015221:Potassium Channels / Q000032:analysis / Q000737:chemistry* / Q000187:drug effects / Q000235:genetics; D024683:Potassium Channels, Tandem Pore Domain; D017434:Protein Structure, Tertiary
chemical_list: D000777:Anesthetics; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain; C420132:potassium channel subfamily K member 3