[The levels of serum interleukins in the children with trauma].
BACKGROUND
We investigated the levels of IL-I, IL-2, IL-4, IL-6, IL-I0 and IL-12 in serum of the children with trauma and its relation with the severity of trauma.


METHODS
We included 45 children with moderate or severe multiple trauma and 21 healthy children for control group to our study. The serum IL-I, IL-2, IL-4, IL-6, IL-IO and IL-12 were measured by micro ELISA.


RESULTS
We found a statistically significant difference between the serum values of IL-l, IL-4, 1 L-6, IL-I0 in the children with trauma and healthy control group. A similar difference was also observed between the control group and the trauma group with injury severity score (ISS) 30 and also ISS 32. Serum values of IL-2 and IL-12 did not show significant difference between the groups.W e detected a positive correlation between ISS and IL-l, IL-6, IL-I0 and IL-I2 (respectively r = 0,602, p = 0,000; r = 0,391, p = 0,008; r = 0,399, p = 0,007; r = 0,475, p = 0,001 ).


CONCLUSIONS
These results point out that serum IL-6, IL-I0, IL-12 and especially IL-l has a close relationship with the severity of the tissue damage after trauma. Key words: Child, cytokine, ISS, trauma, the severity of trauma
Yilmaz
Hayri Levent
HL
Cukurova Universitesi Tip Fakultesi Acil Tip Anabilim Dali, Adana, Turkey. hyilmaz@mail.cu.edu.tr
Dokur
Mehmet
M
Cetiner
Salih
S
Seydaoglu
Gulsah
G
D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007378:Interleukins / Q000097:blood*; D008297:Male; D009104:Multiple Trauma / Q000097:blood* / Q000276:immunology / Q000473:pathology
D007378:Interleukins