Synthesis and pharmacological studies of some 2-t-amino and 2,3-di-t-amino substituted 1,4-naphthoquinones and related compounds.
Series of 2-t-amino and 2,3-di-t-amino substituted-1,4-naphthoquinones have been synthesised from corresponding 1,4-naphthoquinones by reaction with secondary amines. The compounds have been evaluated for their broad spectrum antimicrobial, antiviral and anticancer activity. In the preliminary screening results 8a and 9a have shown profile of an antimicrobial agent.
Tandon
V K
VK
Medicinal Chemistry Research Laboratory, Department of Chemistry, Lucknow University, Lucknow, India.
Singh
R V
RV
Rai
S
S
Chhor
R B
RB
Khan
Z K
ZK
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D010948:Viral Plaque Assay
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007202:Indicators and Reagents; D009285:Naphthoquinones