title: [TS-1/CDDP therapy for advanced gastric cancer as neoadjuvant chemotherapy].
abstract: Five patients with inoperable advanced gastric cancer were treated with combination chemotherapy of TS-1 and cisplatin (CDDP). TS-1 of 80-120 mg/body/day was orally administered for 3 weeks followed by 2 drug-free weeks, and 60 mg/m2/day of CDDP was venally administered on Day 8. It was possible to evaluate all 5 patients for response and toxicity. Only low grade toxicities (Grade 1 or 2) of leukocytopenia, neutrocytopenia, anemia, nausea, diarrhea and stomatitis were seen. Four of 5 patients achieved a partial response, for a response rate of 80.0%. Stomach, liver, lymph node and peritoneal tumors responded to TS-1/CDDP. TS-1/CDDP therapy produces a high response in cases of gastric cancer, and it is useful as a neoadjuvant chemotherapy.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kentarou
authors.initials: K
authors.lastname: Maruyama
authors.forename: Junkou
authors.initials: J
authors.lastname: Furukawa
authors.forename: Naomi
authors.initials: N
authors.lastname: Maruyama
authors.forename: Junnichi
authors.initials: J
authors.lastname: Tanaka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Katsumoto
authors.forename: Hideoki
authors.initials: H
authors.lastname: Yokouchi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakaguchi
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Sue
authors.forename: Wataru
authors.initials: W
authors.lastname: Yoshihara
mesh_terms: D000368:Aged; D000740:Anemia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000008:administration & dosage / Q000009:adverse effects; D011300:Preoperative Care; D011725:Pyridines / Q000008:administration & dosage / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin