title: Changes in the count of pancreatic beta- and alpha-cells and blood glucose level in rats with alloxan-induced diabetes.
abstract: We estimated the count of pancreatic alpha- and beta-cells and blood glucose level at various stages of alloxan-induced diabetes in rats. Alloxan decreased the count of insulin-producing beta-cells, but increased the number of glucagon-secreting alpha-cells in the pancreas (week 1 of diabetes). These changes were accompanied by hyperglycemia. The decrease in blood glucose level in diabetic rats was associated with an increase in beta-cell count against the background of high density of pancreatic alpha-cells.
authors.affiliation: Department of Normal Human Anatomy, Department of Pathophysiology, Department of Pharmacology, Kazan State Medical University.
authors.forename: G N
authors.initials: GN
authors.lastname: Aleeva
authors.forename: A P
authors.initials: AP
authors.lastname: Kiyasov
authors.forename: M M
authors.initials: MM
authors.lastname: Minnebaev
authors.forename: I M
authors.initials: IM
authors.lastname: Burykin
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Khafiz'yanova
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose