title: Determinants of platelet aggregation in 50-70-year-old men from three Japanese communities.
abstract: To investigate the association of lifestyle and constitutional variables with platelet aggregation, we examined the platelet aggregation, serum fatty acid composition, alcohol intake, smoking, and dietary intake of seafood and soybean estimated by a 1-week dietary record in 448 males aged 50-70 in three rural Japanese communities: Ikawa, Akita prefecture (northeast coast), Noichi, Kochi prefecture (southwest coast), and Kyowa, Ibaraki prefecture (central inland). Platelet aggregatory threshold index (PATI) was used to determine the minimum concentration of adenosine 5'-diphosphate (ADP) that caused a non-reversible aggregation of platelets. Intake of seafood and n3-polyunsaturated fatty acid and ingestion of ethanol were higher in the northeast coastal community than in the other two communities. Mean platelet and white blood cell counts were lower in northeast coastal community than in the other two communities. The geometric mean PATI was higher (i.e. platelet aggregation was lower) in the northeast coastal community than the other two communities. Within the entire sample, platelet aggregation correlated inversely with serum level of n3-polyunsaturated fatty acids and gamma-glutamyl transpeptidase, an index of alcohol consumption, and positively with platelet and white blood cell counts. Platelet aggregation tended to correlate positively with serum arachidonic acid. There was no correlation between smoking and platelet aggregation. Our results suggest that seafood intake and moderate alcohol consumption reduce platelet aggregation.
authors.affiliation: Institute of Community Medicine, University of Tsukuba, 1-1-1 Tsukuba-shi, 305-8575, Ibaraki, Japan. imano@kenkoukagaku.jp
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitamura
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.forename: Minako
authors.initials: M
authors.lastname: Kudo
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Naito
authors.forename: Minoru
authors.initials: M
authors.lastname: Iida
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimamoto
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000097:blood*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D004032:Diet; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D012307:Risk Factors; D017747:Seafood
chemical_list: D005227:Fatty Acids