Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging.
OBJECTIVE
To investigate role of exocrine cells in the pancreatic enhancement images at Manganese (II) N, N'-dipyridoxylethlenediamine-N, N'-diacetate 5, 5'-bisc (Mn-DPDP)-enhanced magnetic resonance (MR) imaging.


METHODS
Artificial pancreatic leakage was constructed in six dogs using a fistula tube inserted into the duodenum papillae. Pancreatic juice was collected before and after intravenous infusion of 2 ml/kg of Mn-DPDP at a rate of 2 - 3 ml/min. The Mn content of pancreatic juice was measured by atomic absorption spectroscopy. T(1)-weighted spin-echo images and T(1)-weighted spoiled phase gradient-echo (SPGR) images were obtained prior and approximately 30 min after the administration of Mn-DPDP at 1.5T.


RESULTS
The Mn content of pancreatic secretion increased 60.47 +/- 21.83 micro g/dl after the administration of Mn-DPDP (t = 6.785, P < 0.01). The signal/noise ratio (S/N) of the pancreas increased 53 percent +/- 49 percent and 62 percent +/- 44% on T(1)W spin echo images and SPGR images, respectively.


CONCLUSIONS
Exocrine cells of the pancreas can absorb manganese and excrete it through the pancreatic juice. Exocrine cells play an important role in the enhancement of the pancreas in MR imaging with Mn-DPDP.
Gong
Jingshan
J
Department of Radiology, Shenzhen People's Hospital, China. jshgong@sina.com.cn
Xu
Jianmin
J
Zhou
Kangrong
K
Shen
Kuntang
K
D000818:Animals; D003287:Contrast Media; D004285:Dogs; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000493:pharmacokinetics; D010179:Pancreas / Q000033:anatomy & histology* / Q000378:metabolism; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid