title: S/e-PTFE episcleral buckling implants: an experimental and histopathologic study.
abstract: To investigate tissue changes induced by the implantation of a silicone band coated with expanded polytetrafluoroethylene (S/e-PTFE) used as scleral buckling, an experimental and histopathological study was performed in rabbits. The right eyes of eight rabbits were implanted for 28-85 days with S/e-PTFE. No complications were encountered in any of the eyes, so histopathological examinations could be performed. Encapsulations combined with numerous giant cells were found to be surrounding the implants in seven eyes, and deposits from the mineral salts of calcium were found in three eyes, forming granulomas possibly caused by irregularities of the implant surface. The porous structure allowed a peripheral colonization by fibrovascular tissue. Taking into account the histological results, the use of this material does not appear suitable. However, this inflammation was limited and did not merge on surrounding tissues.
authors.affiliation: Service D'Ophtalmologie, CHU Bordeaux, France. bruno.mortemousque@chu-bordeaux.fr
authors.forename: B
authors.initials: B
authors.lastname: Mortemousque
authors.forename: F
authors.initials: F
authors.lastname: Leger
authors.forename: S
authors.initials: S
authors.lastname: Velou
authors.forename: R
authors.initials: R
authors.lastname: Graffan
authors.forename: J
authors.initials: J
authors.lastname: Colin
authors.forename: J F
authors.initials: JF
authors.lastname: Korobelnik
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D002114:Calcinosis / Q000209:etiology / Q000473:pathology; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D015745:Granuloma, Foreign-Body / Q000209:etiology / Q000473:pathology; D006801:Humans; D008422:Materials Testing; D023421:Models, Animal; D011138:Polytetrafluoroethylene / Q000009:adverse effects; D011817:Rabbits; D012163:Retinal Detachment / Q000601:surgery; D012591:Scleral Buckling / Q000009:adverse effects; D012828:Silicones / Q000009:adverse effects
chemical_list: D001672:Biocompatible Materials; D012828:Silicones; C050905:polytetrafluoroethylene-silicone; D011138:Polytetrafluoroethylene