Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia.
OBJECTIVE
Limitations in clinical understanding of right ventricular relaxation can be attributed to the paucity of information from basic studies in animal models of right ventricular disease. This study examined, in the conscious state, right ventricular relaxation dynamics under normal conditions (n = 15) and in subacute (2-5 weeks) canine models of right ventricular pressure overload (n = 6), volume overload (n = 7), and free wall ischemia (n = 7).


METHODS
Right-heart micromanometric measurements were obtained by using multisensor catheters. A new algorithm was developed to obtain representative ensemble averages of hemodynamic waveform data sets. Right ventricular relaxation was analyzed by using an exponential model with 3 parameters: P(0), tau, and P(b). Significant changes versus control values were determined by means of analysis of variance and the Student unpaired t test with Bonferroni's adjustment.


RESULTS
In the state of pressure overload, right ventricular pressure decay exhibits an increased P(0) (56.2 +/- 19.1 vs 13.1 +/- 5.1 mm Hg [mean +/- SD]) and prolonged tau (57.1 +/- 2.8 vs 27.8 +/- 3.9 ms); there is also a decreased P(b) (-7.9 +/- 1.5 vs 0.28 +/- 1.8 mm Hg). The only significant change in volume overload is an increased asymptote, P(b) (5.3 +/- 2.9 mm Hg). In right ventricular ischemia, prolongation of tau (41.4 +/- 13.0 ms) and decreased P(b) (-1.95 +/- 1.1 mm Hg) attain high significance.


CONCLUSIONS
Distinctive abnormalities in right ventricular relaxation dynamics accompany pressure overload, volume overload, and ischemia and may contribute to clinical right ventricular dysfunction.
Pasipoularides
Ares D
AD
Department of Surgery, Division of Cardiothoracic Surgery, and the Duke Center for Emerging Cardiovascular Technologies, Duke University, Durham, NC 27710, USA.
Shu
Ming
M
Shah
Ashish
A
Glower
Donald D
DD
D000818:Animals; D003243:Consciousness / Q000502:physiology*; D003971:Diastole / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D006352:Heart Ventricles / Q000503:physiopathology*; D008955:Models, Cardiovascular; D009126:Muscle Relaxation / Q000502:physiology*; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology*; D013318:Stroke Volume / Q000502:physiology*; D013599:Systole / Q000502:physiology; D018497:Ventricular Dysfunction, Right / Q000150:complications / Q000503:physiopathology*; D017725:Ventricular Pressure / Q000502:physiology*