[Vanishing bile duct syndrome following allogeneic bone marrow transplantation].
BACKGROUND
Cholestasis following bone marrow transplantation is not rare, but should always be a warning signal. The main causes of cholestasis following bone marrow transplantation are hepatotoxic effects of drugs, venoocclusive disease (VOD), early graft-versus-host disease (GvHD), total parenteral nutrition, viral hepatitis, sepsis and opportunistic infections. Vanishing bile duct syndrome represents a very rare cause for cholestatic symptoms.


METHODS
We report on a 8-year-old boy suffering from myelodysplastic syndrome, who underwent allogeneic bone marrow transplantation and developed biliary ductopenia in terms of a vanishing bile duct syndrome.


CONCLUSIONS
Differential diagnosis for cholestasis following bone marrow transplantation should include the vanishing bile duct syndrome.
Aliani
S
S
Klinik für Kinder- und Jugendmedizin, Universitätskliniken des Saarlandes, Homburg, Germany.
Meyer
S
S
Krenn
T
T
Müller-Molaian
I
I
Graf
N
N
D001652:Bile Ducts / Q000473:pathology; D001706:Biopsy; D016026:Bone Marrow Transplantation; D002648:Child; D002779:Cholestasis / Q000175:diagnosis* / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D009190:Myelodysplastic Syndromes / Q000601:surgery; D011183:Postoperative Complications; D011379:Prognosis; D013577:Syndrome