title: 4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor.
abstract: A new fluorescent ligand for adenosine receptors, obtained by the insertion of a dansylamino-moiety with a linear hexyl spacer in the N4 position of a 1,8-naphthyridine adenosine receptor ligand, proved to possess a high affinity and selectivity for the A1 receptor subtype.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa, Italy. mmacchia@farm.unipi.it
authors.forename: Marco
authors.initials: M
authors.lastname: Macchia
authors.forename: Simone
authors.initials: S
authors.lastname: Bertini
authors.forename: Valeria
authors.initials: V
authors.lastname: Di Bussolo
authors.forename: Clementina
authors.initials: C
authors.lastname: Manera
authors.forename: Claudia
authors.initials: C
authors.lastname: Martini
authors.forename: Filippo
authors.initials: F
authors.lastname: Minutolo
authors.forename: Claudio
authors.initials: C
authors.lastname: Mori
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Saccomanni
authors.forename: Daniela
authors.initials: D
authors.lastname: Tuscano
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Ferrarini
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003619:Dansyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009287:Naphthyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011869:Radioligand Assay; D018047:Receptors, Purinergic P1 / Q000737:chemistry / Q000378:metabolism*
chemical_list: C473766:4-(6-(dansylamino)hexylamino)-7-methyl-2-phenyl-1,8-naphthyridine; D003619:Dansyl Compounds; D005456:Fluorescent Dyes; D009287:Naphthyridines; D018047:Receptors, Purinergic P1