Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2.
Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.
Groth
Casper
C
Department of Molecular Biosciences, The University of Adelaide, SA 5005, Australia. casper.groth@adelaide.edu.au
Nornes
Svanhild
S
McCarty
Rosa
R
Tamme
Richard
R
Lardelli
Michael
M
D000544:Alzheimer Disease / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D015153:Blotting, Western; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008544:Melanocytes / Q000166:cytology / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D009432:Neural Crest; D010802:Phylogeny; D053766:Presenilin-2; D017386:Sequence Homology, Amino Acid; D015027:Zebrafish / Q000196:embryology / Q000235:genetics* / Q000254:growth & development
D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2