An assay to evaluate the long term effects of inflammatory mediators on airway smooth muscle: evidence that TNF(alpha)up-regulates 5-HT(2A) mediated contraction.
Johnson
Simon R
SR
Division of Therapeutics, University Hospital, Nottingham NG7 2UH, UK. simon.johnson@nottingham.ac.uk
D000818:Animals; D018836:Inflammation Mediators / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009924:Organ Culture Techniques; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D018490:Serotonin Agents / Q000494:pharmacology; D013997:Time Factors; D014132:Trachea / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D018836:Inflammation Mediators; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D014409:Tumor Necrosis Factor-alpha; D012701:Serotonin