title: [Laser conization for cervical intraepithelial neoplasias, grade III. Personal experience of 77 cases].
abstract: BACKGROUND
  Evalutation of the efficacy of laser conization for cervical high-grade squamous intraepithelial lesions (Hg-SIL).
  
  
  METHODS
  A retrospective evaluation. Case collection: A total of 77 women, 47 outpatients and 30 inpatients with endocervical CIN3 or CIN2, were treated by carbon dioxide (CO2) laser between 1993 and 1995. A preoperative diagnosis has been made by means of Pap-smear, colposcopy and marked biopsy. In 47 cases a laser conization was performed in Day Surgery, without vessel constrictors or local anesthetics. In 30 cases a narcosis (Diprivan ) was induced. The former were discharged 2-3 hours and the latter 24 hours after treatment.
  
  
  RESULTS
  The histological examination confirmed preoperative diagnosis in 64 (86.5%) cases and negligible one grade discrepancy was reported in 7 cases (6 over- and 1 underestimated); missed invasion and no free margins were reported in the remaining 4 and 2 patients respectively, so these latter 6 patients were submitted to other surgical procedures. No serious complications occurred with the exception of mild vaginal postoperative bleeding. During the follow-up of 36-82 months, cervical alterations were described only in 12 out of 71 cases, flat condilomatosy in 8 cases, CIN2 in 2 patients and CIN3 in other 2 patients. At present, all the patients are free of disease.
  
  
  CONCLUSIONS
  The conization with dioxide laser is a good therapy for cervical intraepithelial neoplasia, even if expensive; infact poor side-effects are observed as well as a very good reliability.
authors.affiliation: Divisione di Ginecologia Oncologica, IFO Polo Oncologico, Rome, Italy.
authors.forename: F F
authors.initials: FF
authors.lastname: Diotallevi
authors.forename: A
authors.initials: A
authors.lastname: Iacovelli
authors.forename: C
authors.initials: C
authors.lastname: Vincenzoni
authors.forename: M
authors.initials: M
authors.lastname: Atlante
mesh_terms: D000328:Adult; D019092:Conization / Q000379:methods*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008875:Middle Aged; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*