[Photo dermatology].
Photodermatology has become an important part of the dermatologist's area of focus. This subspeciality is not only involved with studying basic biological processes such as the effects of ultraviolet (UV) irradiation on the skin's immune system (photo-immunology), melanocytes or DNA (carcinogenesis), but also with clinical issues such as photoprotection, photosensitive skin diseases (photodermatoses) and phototherapy. Increasing knowledge about the effects of UV irradiation on the skin, with or without photosensitising agents, has led to the development of new forms of photo(chemo)therapy. These allow good therapeutic results to be achieved in the treatment of not only psoriasis, but also other chronic inflammatory skin diseases, with minimal side effects. DNA can absorb UV irradiation. This can lead to irreversible DNA damage and mutations in genes responsible for cell cycle control. These events can lead to skin cancer. The presence of pheomelanin, which is an inferior type of UV light-absorbing melanin, can add to this process of DNA damage. The three most important types of skin cancer are basal cell carcinoma (more than 30,000 new patients per year in the Netherlands), squamous cell carcinoma and melanoma.
de Rie
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Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Huidziekten, Meibergdreef 9, 1105 AZ Amsterdam. m.a.derie@amc.uva.nl
Pavel
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D002280:Basal Cell Carcinoma / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D006801:Humans; D008545:Melanoma / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control; D012871:Skin Diseases / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000532:radiotherapy*; D014466:Ultraviolet Rays / Q000009:adverse effects; D014467:Ultraviolet Therapy / Q000009:adverse effects