Protective effect of Biolan during ischemic damages to cultured cerebellar granular cells.
Biolan containing carnosine and delta sleep-inducing peptide produced a protective effect on cerebellar granular cells from 7-day-old rats exposed in culture to ischemia (oxygen and glucose deprivation) and cytotoxic influence of glutamate. These results indicate that Biolan holds much promise for correction of ischemic brain damages in clinical practice.
Khaspekov
L G
LG
Institute of Brain Research, Russian Academy of Medical Sciences, Moscow. khaspek@cc.nifhi.ac.ru
Klyushnik
T P
TP
Dupin
A M
AM
Lyzhin
A A
AA
Bezrukov
M V
MV
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D005947:Glucose / Q000378:metabolism; D018698:Glutamic Acid / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D010455:Peptides; D018698:Glutamic Acid; D005947:Glucose; D010100:Oxygen