Wnt signaling: a complex issue.
The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification. Together with other families of secreted factors such as TGF beta s, FGFs, Hedgehog and Notch proteins, Wnt growth factors are crucially implicated in these processes. Here, we will first discuss molecular mechanisms and then consider some biological consequences of Wnt signaling.
Hendriks
Bart
B
Fetal and Pediatric Surgical Research Unit, Department of Surgery, University Children's Hospital Zürich, Steinwiesstr. 75, CH-8032 Zürich, Switzerland.
Reichmann
Ernst
E
D000818:Animals; D003598:Cytoskeletal Proteins / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D003598:Cytoskeletal Proteins; D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins