title: A clinicopathological study of acute necrotising jejunoileitis.
abstract: We describe a variety of acute necrotizing enteritis that is endemic to the Indian subcontinent. During the period 1992-1998, 18 cases of acute jejunoileitis (AJI) were managed. Only those in whom the diagnosis was confirmed at laparotomy have been included in this study. The most common symptoms were abdominal pain (100%), fever (77%), and blood in the stool (100%). A stricture following conservative treatment was present in 1 case. The mean age at presentation was 6.5 years (range 6 months-12 years); the male:female ratio was 1.2:1. All cases were seen during May-October. Routine investigations and X-ray films were nonspecific. Stool cultures did not show any clostridia, shigella, or salmonella. The jejunum was involved most commonly; 28% of patients did not require a bowel resection. Only 1 child presented with shock; the mortality was less than 5%. Short-bowel syndrome resulted in 1 patient due to extensive disease. The histopathologic features that were characteristic of the disease were patchy transmural mucosal necrosis extending centrifugally with submucosal edema, interstitial hemorrhage, type III hypersensitivity reaction, and extensive neovascularization. This type of AJI seen in South/Southeast Asia does not seem to be due a to bacterial infective etiology; immune mediation is suggested. The milder forms can be confused with dysentery. Mild forms of the disease can be managed conservatively, but carry the risk of developing strictures. This disease should be suspected in cases of prolonged dysentery during the summer and autumn months.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi-110029, India.
authors.forename: V V S S
authors.initials: VV
authors.lastname: Chandrasekharam
authors.forename: M
authors.initials: M
authors.lastname: Mathur
authors.forename: S
authors.initials: S
authors.lastname: Agarwala
authors.forename: D K
authors.initials: DK
authors.lastname: Mitra
authors.forename: V
authors.initials: V
authors.lastname: Bhatnagar
mesh_terms: D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D004751:Enteritis / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007079:Ileitis / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D007223:Infant; D007579:Jejunal Diseases / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D008297:Male; D009336:Necrosis