Tributyltin and triphenyltin induce spermatogenesis in ovary of female abalone, Haliotis gigantea.
Two-month flow-through exposure experiments of tributyltin (TBT) and triphenyltin (TPhT) were conducted with abalone, Haliotis gigantea. Nominal concentrations of 100 ng TBT/l and 100 ng TPhT/l caused significant spermatogenesis in ovaries of exposed females. There were also significantly more contracted primary oocytes observed in females exposed to either TBT or TPhT than controls. The incidence of two types of unknown cells was also significant in females exposed to TPhT. No significant histological changes were observed in testis of exposed males. This ovarian spermatogenesis caused by TBT and/or TPhT resembles gastropod imposex. Remarkably high concentrations of TBT and TPhT were observed in the head (including central nervous system ganglia), compared to muscles concentrations. Accumulation of TBT and TPhT in the head may disturb reproductive hormonal regulators through neuropeptides released from ganglia. This, as well as possible aromatase inhibition, may be one of the inducers for spermatogenesis in the abalone ovaries.
Horiguchi
T
T
National Institute for Environmental Studies, Environmental Chemistry Division, Tsukuba, Ibaraki, Japan. thorigu@nies.go.jp
Kojima
M
M
Kaya
M
M
Matsuo
T
T
Shiraishi
H
H
Morita
M
M
Adachi
Y
Y
D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects*; D012734:Disorders of Sex Development / Q000209:etiology* / Q000662:veterinary*; D004781:Environmental Exposure; D005260:Female; D008297:Male; D008974:Mollusca / Q000502:physiology*; D009947:Organotin Compounds / Q000009:adverse effects*; D010053:Ovary / Q000502:physiology*; D013091:Spermatogenesis / Q000187:drug effects*; D014220:Trialkyltin Compounds / Q000009:adverse effects*
D000890:Anti-Infective Agents; D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C011559:tributyltin; C030665:triphenyltin