title: Silicon tether-aided coupling metathesis: application to the synthesis of attenol A.
abstract: A new synthesis of attenol A is described. Key features of this work include a crucial silicon tether-aided coupling metathesis step and the use of iodoetherification as an efficient protection method for 1,5-ene-ols. [reaction: see text]
authors.affiliation: Laboratoire de Chimie Organique et Bioorganique associé au CNRS, Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, 3 Rue Alfred Werner, F-68093 Mulhouse Cedex, France. p.vandeweghe@uha.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Van de Weghe
authors.forename: Darina
authors.initials: D
authors.lastname: Aoun
authors.forename: Jean-Guy
authors.initials: JG
authors.lastname: Boiteau
authors.forename: Jacques
authors.initials: J
authors.lastname: Eustache
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000633:toxicity; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000633:toxicity; D015394:Molecular Structure; D012825:Silicon
chemical_list: D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; C423354:attenol A; D012825:Silicon