title: Morphologic characteristics of aortic valve sclerosis by transesophageal echocardiography: importance for the prediction of coronary artery disease.
abstract: Aortic valve sclerosis (AVS) is associated with myocardial infarction and mortality. Since it is not cost effective to test all patients with AVS for coronary artery disease (CAD), the identification of high-risk patients is important. We developed a morphologic classification system for AVS by transesophageal echocardiography and correlated the subtypes of AVS with the presence of cardiovascular disease. AVS in general was not associated with CAD. However, among patients with mixed nodular and diffuse AVS, the prevalence of CAD and previous coronary artery bypass graft surgery were higher than among those without this mixed type (p = 0.02 and 0.008, respectively). We concluded that the finding of mixed nodular and diffuse AVS identifies patients at increased risk for CAD. Thus, the echocardiographic assessment of AVS morphology is of clinical relevance.
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, Calif 90048, USA. tolstrupk@cshs.org
authors.forename: Kristen
authors.initials: K
authors.lastname: Tolstrup
authors.forename: Michael  H
authors.initials: M
authors.lastname: Crawford
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Roldan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging* / Q000473:pathology*; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D017548:Echocardiography, Transesophageal; D006349:Heart Valve Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009516:New Mexico / Q000453:epidemiology; D015588:Observer Variation; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D012598:Sclerosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome