title: Magnetocardiographic indices of left ventricular hypertrophy.
abstract: OBJECTIVE
  We tested the hypothesis that multichannel magnetocardiographic (MCG) mapping can detect and quantify the degree of left ventricular hypertrophy (LVH).
  
  
  METHODS
  A cross-sectional study.
  
  
  METHODS
  Helsinki University Central Hospital, a tertiary referral center.
  
  
  METHODS
  Forty-two patients with pressure overload induced LVH by gender-specific echocardiographic criteria (LVH group), and 12 healthy middle-aged controls.
  
  
  METHODS
  MCG QRS-T area integrals and QRS-T angle in magnetic field maps in relation to echocardiographic LVH as well as left ventricular (LV) mass and structure. Conventional 12-lead electrocardiographic (ECG) LVH indices (Sokolow-Lyon voltage, Cornell voltage, Cornell voltage duration product) were assessed for comparison.
  
  
  RESULTS
  MCG QRS- and T-wave integrals provided complementary information of echocardiographic LV mass. Their combination, the QRS-T integral, and the QRS-T angle were increased in patients with LVH and, in those patients, correlated significantly with LV mass indexed to body surface area (r = 0.455;P = 0.002 and r= 0.379; P= 0.013, respectively). A QRS-T integral 16000 fT.s had identical sensitivity of 62% at 92% specificity as the gender-adjusted Cornell voltage duration product of 240 micro V.s for the detection of LVH.
  
  
  CONCLUSIONS
  The MCG method can detect patients with LVH and also quantify the degree of LVH in patients with increased LV mass.
authors.affiliation: Laboratory of Biomedical Engineering, Helsinki University of Technology, Helsinki University Central Hospital; Helsinki, Finland. milla.karvonen@hut.fi
authors.forename: Milla
authors.initials: M
authors.lastname: Karvonen
authors.forename: Lasse
authors.initials: L
authors.lastname: Oikarinen
authors.forename: Panu
authors.initials: P
authors.lastname: Takala
authors.forename: Maija
authors.initials: M
authors.lastname: Kaartinen
authors.forename: Juhani
authors.initials: J
authors.lastname: Rossinen
authors.forename: Helena
authors.initials: H
authors.lastname: Hänninen
authors.forename: Juha
authors.initials: J
authors.lastname: Montonen
authors.forename: Jukka
authors.initials: J
authors.lastname: Nenonen
authors.forename: Markku
authors.initials: M
authors.lastname: Mäkijärvi
authors.forename: Pekka
authors.initials: P
authors.lastname: Keto
authors.forename: Lauri
authors.initials: L
authors.lastname: Toivonen
authors.forename: Markku S
authors.initials: MS
authors.lastname: Nieminen
authors.forename: Toivo
authors.initials: T
authors.lastname: Katila
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D014463:Ultrasonography