title: 4-tert-octylphenol and 17beta-estradiol applied by feeding to flounder Platichthys flesus: induction of vitellogenin and accumulation in tissues.
abstract: In order to simulate a possible natural administration route of xenoestrogens male flounder Platichthys flesus were exposed via the diet to the alkylphenol 4-tert-octylphenol. Treatment with 4-tert-octylphenol (10, 50 and 100 mg OP kg(-1) BW) or 17beta-estradiol (0.05 mg kg(-1) BW) every second day during a period of 11 days resulted in a significant increase in plasma vitellogenin (Vtg) concentrations. The induction of Vtg was greatest in the fish receiving 50 mg OP kg-' BW. A significant accumulation of 4-tert-octylphenol was found in liver and muscle tissue of the OP treated groups. The tissue concentrations of 4-tert-octylphenol and the plasma vitellogenin concentration were positively correlated. The results show that 4-tert-octylphenol accumulates in liver and muscles of flounder P. flesus, and exerts estrogenic effects such as vitellogenin induction.
authors.affiliation: Institute of Biology, University of Southern Denmark, Odense. louisem@biology.sdu.dk
authors.forename: Louise L
authors.initials: LL
authors.lastname: Madsen
authors.forename: Bodil
authors.initials: B
authors.lastname: Korsgaard
authors.forename: Poul
authors.initials: P
authors.lastname: Bjerregaard
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D004032:Diet; D004958:Estradiol / Q000009:adverse effects* / Q000493:pharmacokinetics*; D005432:Flounder / Q000502:physiology*; D008099:Liver / Q000737:chemistry; D008297:Male; D018482:Muscle, Skeletal; D010636:Phenols / Q000009:adverse effects* / Q000493:pharmacokinetics*; D013501:Surface-Active Agents / Q000009:adverse effects* / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014819:Vitellogenins / Q000096:biosynthesis*
chemical_list: D010636:Phenols; D013501:Surface-Active Agents; D014819:Vitellogenins; D004958:Estradiol; C105260:4-tert-octylphenol