Two pathways to NF-kappaB.
NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune disease.
Pomerantz
Joel L
JL
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Baltimore
David
D
D000818:Animals; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D015533:Transcriptional Activation
D016328:NF-kappa B