title: Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase.
abstract: To evaluate the antihyperlipidemic activities of Orengedokuto (OT) and Daio-Orengedokuto (DOT), the inhibitory effects of these polyprescriptions on HMG-CoA reductase and pancreatic lipase and on the rat hyperlipidemic model induced by Triton WR-1339 were measured. OT potently inhibited HMG-CoA reductase but did not inhibit lipase. Among their ingredients, Coptidis Rhizoma was the most potent inhibitor, followed by Rhei Rhizoma. The HMG-CoA reductase-inhibitory activity of 80% EtOH extract was superior to that of water extract. However, DOT potently inhibited HMG CoA-reductase as well as pancreatic lipase. In the rat hyperlipidemic model induced by Triton WR-1339, OT and DOT decreased serum total cholesterol and low-density lipoprotein cholesterol levels. DOT also decreased serum triglyceride levels, but OT did not decrease it. These results suggest that the antihyperlipidemic activity of DOT may originate from the inhibition of pancreatic lipase as well as HMG-CoA reductase.
authors.affiliation: College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Young-Suk
authors.initials: YS
authors.lastname: Kim
authors.forename: Eun-Ah
authors.initials: EA
authors.lastname: Jung
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Shin
authors.forename: Jong-Chul
authors.initials: JC
authors.lastname: Chang
authors.forename: Hyung-Kil
authors.initials: HK
authors.lastname: Yang
authors.forename: Nam-Jae
authors.initials: NJ
authors.lastname: Kim
authors.forename: Ki-Ho
authors.initials: KH
authors.lastname: Cho
authors.forename: Hyung-Sup
authors.initials: HS
authors.lastname: Bae
authors.forename: Sang-Kwan
authors.initials: SK
authors.lastname: Moon
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy / Q000201:enzymology; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C061676:oren gedoku to; D006903:Hydroxymethylglutaryl CoA Reductases; D008049:Lipase