[Appendectomy reduces the risk of development of ulcerative colitis].
The etiology and pathogenesis of ulcerative colitis are still unclear. There is, however, a growing consensus that the disease is characterized by a complex interaction between genetic and environmental influences. Many studies in the last few years have suggested that appendectomy reduces the risk of development and improves the course of ulcerative colitis. The underlying mechanism of this effect is unknown. The appendix seems to play a more important role in the development and modulation of the mucosal immune system than believed so far.
Buergel
N
N
Medizinische Klinik I-Gastroenterologie, Infektiologie und Rheumatologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200 Berlin.
Schulzke
J D
JD
Zeitz
M
M
D000293:Adolescent; D000328:Adult; D000818:Animals; D001062:Appendectomy; D001065:Appendix / Q000276:immunology / Q000502:physiology; D016022:Case-Control Studies; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D004777:Environment; D005260:Female; D005500:Follow-Up Studies; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D016017:Odds Ratio; D013997:Time Factors