Paget's disease of bone: presentation, extent and response to bisphosphonates.
According to a radiograph survey in 1982, Paget's disease of bone is common in Ireland but, to date, there have been no clinical reports. In a survey of 24 patients with Paget's disease of bone, we found monostotic disease in 8 and polyostotic disease in 16. Complications were common including deformity (21%), fracture (17%) and deafness (8%). Bisphosphonate therapy induced a remission in 22 patients.
Wang
L M
LM
St. Michael's Hospital, Dún Laoghaire, Co. Dublin.
Au-Yeong
M L
ML
McKenna
M J
MJ
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*
D004164:Diphosphonates; D000469:Alkaline Phosphatase