title: Structural modification of collagen during nonenzymatic glycosylation in vitro.
abstract: We studied changes in collagen resistance to proteases and formation of new fluorescent compounds during in vitro nonenzymatic glycosylation. The inhibitory effects of guanidine chloride and catalase were different: guanidine chloride inhibited cross-linking in collagen molecules, while catalase inhibited the formation of chromophore-containing compounds.
authors.affiliation: VILAR Research, Training, and Methodological Center of Biomedical Technologies, Moscow.
authors.forename: V V
authors.initials: VV
authors.lastname: Berzhitskaya
authors.forename: M V
authors.initials: MV
authors.lastname: Timofeeva
authors.forename: G A
authors.initials: GA
authors.lastname: Rebrova
authors.forename: V K
authors.initials: VK
authors.lastname: Vasilevskii
authors.forename: So
authors.initials: S
authors.lastname: San Kho
authors.forename: L B
authors.initials: LB
authors.lastname: Rebrov
authors.forename: V A
authors.initials: VA
authors.lastname: Bykov
mesh_terms: D002374:Catalase / Q000378:metabolism; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D017364:Collagenases / Q000494:pharmacology; D006031:Glycosylation; D019791:Guanidine / Q000494:pharmacology; D015416:Maillard Reaction; D010434:Pepsin A / Q000494:pharmacology; D011402:Pronase / Q000494:pharmacology; D012995:Solubility; D013050:Spectrometry, Fluorescence; D013997:Time Factors
chemical_list: D003094:Collagen; D002374:Catalase; D010434:Pepsin A; D017364:Collagenases; D011402:Pronase; D019791:Guanidine