Toxicity to topical dimethyl sulfoxide (DMSO) when used as an extravasation antidote.
DMSO is a dipolar, aprotic, hygroscopic solvent for which a large number of pharmacologic properties have been claimed. Topical DMSO is considered an effective and safe antidote to be used with topical cooling after extravasations of vesicant drugs. A case of toxicity after its use as an antidote is described. Furthermore, the increasing importance of DMSO pharmacology, as its use in haematologic patients is spreading, is reviewed.
Creus
N
N
Pharmacy Department, Hospital Clinic of Barcelona, c/Villarroel 170, 08036 Barcelona, Spain. ncreus@clinic.ub.es
Mateu
J
J
Massó
J
J
Codina
C
C
Ribas
J
J
D000287:Administration, Topical; D000328:Adult; D000931:Antidotes / Q000009:adverse effects*; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D008297:Male
D000931:Antidotes; D004121:Dimethyl Sulfoxide