Spanish language mapping using MEG: a validation study.
The purpose of the present study was to compare magnetoencephalography (MEG) data with the results of the intracarotid amytal procedure (IAP). Twenty-one native Spanish-speaking patients with intractable epilepsy underwent MEG language mapping. A subset of 8 patients also underwent an IAP. With the exception of 2 patients who showed right hemisphere dominance, all other patients showed left hemisphere dominance for language on the MEG recording. The IAP findings were consistent with MEG results in 7 patients. The eighth patient who, according to the MEG data, had probable right hemisphere dominance for language did not show clear hemispheric specialization for language on the IAP and suffered a transient global aphasia following a right temporal lobotomy. These results suggests that MEG-based language mapping can play an important role in presurgical clinical evaluation.
Maestú
Fernando
F
Magnetoencephalography Center, Dr. Pérez Modrego, Cognitive Process, Universidad Complutense Madrid, Madrid, Spain.
Ortiz
Tomás
T
Fernandez
Alberto
A
Amo
Carlos
C
Martin
Pilar
P
Fernández
Santiago
S
Sola
Rafael G
RG
D000328:Adult; D000654:Amobarbital; D001037:Aphasia / Q000175:diagnosis / Q000503:physiopathology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004567:Electrodes, Implanted; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007802:Language; D015225:Magnetoencephalography; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology; D011612:Psychosurgery; D011932:Reading; D012815:Signal Processing, Computer-Assisted; D013067:Speech Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000503:physiopathology / Q000601:surgery
D000654:Amobarbital