title: Antibacterial therapy of neurosyphilis: lack of impact of new therapies.
abstract: Neurosyphilis is caused by the spirochete Treponema pallidum. These organisms divide slowly, requiring long exposure to antibacterials for treatment success. In order for an antibacterial to be effective in the therapy of neurosyphilis, it must achieve treponemicidal concentrations in the CSF, have a long half-life and be given in a treatment regimen that favours compliance. Penicillin was first introduced for the treatment of syphilis in 1943, and despite interest in the use of amoxicillin, erythromycin, tetracycline, doxycycline, ceftriaxone and azithromycin, penicillin remains the only recommended antibacterial agent for neurosyphilis.
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: Latisha
authors.initials: L
authors.lastname: Ali
authors.forename: Karen L
authors.initials: KL
authors.lastname: Roos
mesh_terms: D000993:Antitreponemal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D009494:Neurosyphilis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D010406:Penicillins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome; D014210:Treponema pallidum / Q000187:drug effects*
chemical_list: D000993:Antitreponemal Agents; D010406:Penicillins