title: Prostaglandin F synthase.
abstract: Prostaglandin (PG) F2 is synthesized via three pathways from PGE2, PGD2, or PGH2 by PGE 9-ketoreductase, PGD 11-ketoreductase, or PGH 9-, 11-endoperoxide reductase, respectively. The enzymological and molecular biological properties of these enzymes have been reported in work over the last 30 years. Here, these three pathways of PGF synthesis by these enzymes are reviewed, and the physiological roles of the enzymes are discussed.
authors.affiliation: Division of Applied Life Sciences, Graduate School of Integrated Sciences and Arts, University of East Asia, Shimonoseki, Yamaguchi, Japan. watanabe@po.cc.toua-u.ac.jp
authors.forename: Kikuko
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000737:chemistry / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D008968:Molecular Conformation; D011457:Prostaglandins D / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000096:biosynthesis; D011463:Prostaglandins H / Q000378:metabolism
chemical_list: D007527:Isoenzymes; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D011463:Prostaglandins H; D006911:Hydroxyprostaglandin Dehydrogenases; C031051:prostaglandin-F synthase; C035858:prostaglandin-E2 9-reductase