title: Straightforward syntheses of furanomycin derivatives and their biological evaluation.
abstract: Several types of furanomycin analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its desmethyl derivative showed antibacterial activity, pointing towards a narrow structure-activity relationship.
authors.affiliation: Institut für Organische Chemie, Universität des Saarlandes, Im Stadtwald, Geb. 23.2, 66123 Saarbrücken, Germany. u.kazmaier@mx.uni-sb.de
authors.forename: Uli
authors.initials: U
authors.lastname: Kazmaier
authors.forename: Saskia
authors.initials: S
authors.lastname: Pähler
authors.forename: Rainer
authors.initials: R
authors.lastname: Endermann
authors.forename: Dieter
authors.initials: D
authors.lastname: Häbich
authors.forename: Hein-Peter
authors.initials: HP
authors.lastname: Kroll
authors.forename: Bernd
authors.initials: B
authors.lastname: Riedl
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005051:Eubacterium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; C063753:furanomycin