Penetration of topically administered ofloxacin and trimethoprim into aqueous humor.
Ocular penetration of two topical antibiotics used to treat bacterial conjunctivitis was assessed in adult volunteers scheduled for cataract surgery. In this randomized, parallel-group study, patients instilled trimethoprim sulfate 0.1%/polymyxin B (n = 23) or ofloxacin 0.3% (n = 25) QID for 3 days, plus 4 instillations in the hour before surgery. Analysis of aqueous humor samples obtained during surgery showed a 2.4-fold greater concentration of ofloxacin over trimethoprim (1.135 micro g/ml vs 0.470 micro g/ml; P <.0001). The greater concentration of ofloxacin in ocular tissue coupled with its superior antibacterial activity profile supports its use as an alternative to trimethoprim/polymyxin B for treatment of bacterial conjunctivitis.
Price
Francis W
FW
Cornea Research Foundation, Indianapolis, Indiana, USA. fprice@pricevisiongroup.net
Dobbins
Kendall
K
Zeh
William
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D015242:Ofloxacin / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions; D010539:Permeability; D014295:Trimethoprim / Q000493:pharmacokinetics*
D000891:Anti-Infective Agents, Local; D009883:Ophthalmic Solutions; D015242:Ofloxacin; D014295:Trimethoprim