title: Rapid access to tetracyclic ring system of lennoxamine type natural product by combined use of a novel three-component reaction and Pummerer cyclization.
abstract: From readily available allylamine, aldehyde and isocyanoacetamide, a three-component reaction followed by a Pummerer cyclization provided tetracyclic ring systems (6-7-5-6 and 6-6-5-6) in excellent overall yields.
authors.affiliation: Institut de Chimie des Substances Naturelles, 91198 Gif-sur-Yvette, France.
authors.forename: Rocio
authors.initials: R
authors.lastname: Gámez Montaño
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D004146:Dioxanes / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis
chemical_list: D004146:Dioxanes; D006571:Heterocyclic Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; C442893:lennoxamine