Oxidant-antioxidant status in patients with oral squamous cell carcinomas at different intraoral sites.
OBJECTIVE
To compare the extent of lipid peroxidation and the status of antioxidants in tumor and venous blood of patients with oral squamous cell carcinoma (OSCC) at different intraoral sites.


METHODS
Twenty four patients with OSCC at different intraoral sites and an equal number of age- and sex-matched reference subjects were chosen for the study. The concentrations of lipid peroxides and reduced glutathione (GSH) and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were estimated in tissues and blood.


RESULTS
Diminished lipid peroxidation in tumor tissue was accompanied by decreased activities of SOD and CAT with increase in GSH and GSH-dependent enzymes. In contrast, enhanced lipid peroxidation with decrease in antioxidants was observed in the venous blood of OSCC patients.


CONCLUSIONS
No significant differences in lipid peroxidation and antioxidant levels were observed between patients with OSCC at different intraoral sites. However, our results revealed differences between the tumor and blood with respect to their susceptibility to lipid peroxidation and antioxidant status.
Subapriya
R
R
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.
Kumaraguruparan
R
R
Ramachandran
C R
CR
Nagini
S
S
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione