Cerebrospinal fluid tissue transglutaminase in vascular dementia.
The enzyme tissue transglutaminase (tTG), an indicator of acute cell death, is found in brains of Alzheimer's and Huntington's disease patients. tTG, as a specific marker for apoptosis, may therefore be a powerful biochemical marker of the acute degenerating process in vivo and may be useful in discrimination between vascular dementia (VaD) and Alzheimer's disease (AD). It may serve as completion of CSF analysis in diagnosis of dementing disorders and be a simple way of assessing the efficacy of possible new anti-apoptotic drugs.
Bonelli
Raphael M
RM
Department of Neurology and Psychiatry, Hospital BHB Eggenberg, Bergstrasse 27, A-8021 Graz, Austria. rm.bonelli@nextra.at
Aschoff
Andreas
A
Jirikowski
Gustaf
G
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid; D015415:Biomarkers; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid*; D006801:Humans; D011503:Transglutaminases / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000378:metabolism
D015415:Biomarkers; D016875:tau Proteins; D011503:Transglutaminases