Mathematical analysis of subtypes of muscarinic receptors modulating heart and respiratory rhythms in rats.
Mathematical analysis of the data obtained in experiments on the whole organism revealed that blockade of M(2)-cholinergic receptors increased both heart and respiratory rates. Blockade of M(1)-cholinergic receptors alleviated tachycardia induced by M(2)-receptor blockade.
Lychakov
A V
AV
Institute of Toxicology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Belyaev
V A
VA
Kosmachev
A B
AB
Glukhova
R I
RI
Dagaev
S G
SG
Dolgo-Saburov
V B
VB
D000818:Animals; D006321:Heart / Q000502:physiology*; D006339:Heart Rate; D008024:Ligands; D016014:Linear Models; D008962:Models, Theoretical; D051381:Rats; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011950:Receptors, Cholinergic / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012119:Respiration; D013909:Thorax / Q000502:physiology
D008024:Ligands; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic