title: Treatment of vomiting after paediatric strabismus surgery with granisetron, droperidol, and metoclopramide.
abstract: We have compared the efficacy and safety of granisetron, droperidol, and metoclopramide in the treatment of postoperative vomiting (POV) in children scheduled for strabismus surgery. After experiencing POV during the first 3 h after recovery from anaesthesia, 120 patients received intravenously, in a randomized, double-blind manner, granisetron 40 microg/kg, droperidol 50 microg/kg, or metoclopramide 0.25 mg/kg (n = 40 in each group). The patients were then observed for 24 h after administering the study drugs. Emesis-free episodes were more often observed in patients who had received granisetron (88%) than in those who had received droperidol (63%) or metoclopramide (58%; p < 0.05). No clinically serious adverse events were observed in any group. In conclusion, granisetron is more effective than droperidol or metoclopramide in the treatment of POV after paediatric strabismus surgery.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Fujii
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Ito
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use*; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy*; D013285:Strabismus / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D004329:Droperidol; D017829:Granisetron; D008787:Metoclopramide