Different types of epithelial cadherin alterations play different roles in human carcinogenesis.
Epithelial cadherin (E-cadherin) gene and protein alterations are implicated in the existence of two clearly distinct types of tumors in the stomach (isolated cell and glandular carcinomas), breast (lobular and ductal carcinomas), and thyroid (papillary and follicular carcinomas), as well as in the occurrence of poorly differentiated foci in colorectal and prostate adenocarcinomas. A thorough correlation between clinicopathologic features and molecular data, and the study of early lesions from familial cases provide clues for the understanding of the role played by E-cadherin in these settings.
Sobrinho-Simões
Manuel
M
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal. ssimoes@ipatimup.pt
Oliveira
Carla
C
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D000328:Adult; D017668:Age of Onset; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D017809:Fatal Outcome; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D010375:Pedigree; D011322:Primary Prevention; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control
D015820:Cadherins