title: GSTT1 null genotype increases risk of premenopausal breast cancer.
abstract: The NAT2, GSTM1 and GSTT1 genes are known candidate cancer susceptibility markers and have been investigated in breast cancer susceptibility with conflicting results. We conducted a case-control study to investigate the role of NAT2, GSTM1 and GSTT1 in premenopausal breast cancer. Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. Our results suggest that the GSTT1 null genotype may play a role in early onset breast cancer.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Vic. 3151, Australia. melanie.matheson@med.monash.edu.au
authors.forename: Melanie C
authors.initials: MC
authors.lastname: Matheson
authors.forename: Trevor
authors.initials: T
authors.lastname: Stevenson
authors.forename: Shiva
authors.initials: S
authors.lastname: Akbarzadeh
authors.forename: David N
authors.initials: DN
authors.lastname: Propert
mesh_terms: D000328:Adult; D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000502:physiology; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics* / Q000502:physiology; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017697:Premenopause / Q000235:genetics* / Q000378:metabolism*; D012306:Risk
chemical_list: D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase; C478900:NAT2 protein, human; C413545:glutathione S-transferase T1