Chocolate, an effective means of oral drug delivery in rats.
Oral gavage is an important procedure for drug discovery and efficacy studies using rodents. However, there are welfare issues related to the use of the method by inexperienced persons or for long-term studies. The authors describe an effective method of administering drugs to rats by mixing the drug with chocolate to provide a consistent and reliable method of oral drug delivery to large groups of rats for a long period of time.
Huang-Brown
Karen M
KM
Department of Orthopedics, Department of Comparative Medicine, The Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033, USA.
Guhad
Faisal A
FA
D000284:Administration, Oral; D000827:Animal Welfare; D000818:Animals; D002099:Cacao; D016503:Drug Delivery Systems / Q000941:ethics / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000941:ethics / Q000379:methods*; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
D004364:Pharmaceutical Preparations