Immunohistochemical localization of cyclooxygenase-2 in radicular cysts.
OBJECTIVE
The purpose of this study was to investigate the expression of cyclooxygenase-2 (COX-2) in radicular cysts.


METHODS
Thirty biopsy specimens of radicular cysts were examined using immunohistochemistry. A peroxidase-labelled streptavidin-biotin technique was used for identification of the COX-2. Fisher's exact test (two-tail) was used for statistical analysis of the results.


RESULTS
The result demonstrated that COX-2 expression was significantly higher in radicular cysts with higher levels of inflammatory infiltrates. COX-2 stain was detected in the lining epithelium, subepithelial fibroblasts, macrophages and endothelial cells in all specimens.


CONCLUSIONS
COX-2 expression is significantly higher in radicular cysts. COX-2 may play an important role in the pathogenesis of radicular cysts.
Tsai
C-H
CH
Department of Oral Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Huang
F-M
FM
Yang
L-C
LC
Chou
M-Y
MY
Chang
Y-C
YC
D002196:Capillaries / Q000201:enzymology / Q000473:pathology; D051546:Cyclooxygenase 2; D004730:Endothelium, Vascular / Q000201:enzymology / Q000473:pathology; D004848:Epithelium / Q000201:enzymology / Q000473:pathology; D005347:Fibroblasts / Q000201:enzymology / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis*; D008264:Macrophages / Q000201:enzymology / Q000473:pathology; D008565:Membrane Proteins; D010544:Peroxidases / Q000032:analysis*; D011451:Prostaglandin-Endoperoxide Synthases / Q000032:analysis*; D011842:Radicular Cyst / Q000201:enzymology* / Q000473:pathology; D013223:Statistics as Topic
D007527:Isoenzymes; D008565:Membrane Proteins; D010544:Peroxidases; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases