Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. I. Alterations of myelinated axons.
Classical and ultrastructural neuropathology of prion diseases are generally well described. Here we report that alterations of myelinated fibres in hamsters infected either with polioencephalopathic strains of scrapie or panencephalopathic strains of CJD (Echigo-1) are virtually identical and differ only quantitatively. In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres.
Liberski
Paweł P
PP
Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Poland. ppliber@csk.am.lodz.pl.
Bratosiewicz-Wasik
Jolanta
J
Gajdusek
D Carleton
DC
Brown
Paul
P
D000818:Animals; D001369:Axons / Q000473:pathology* / Q000648:ultrastructure; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D006224:Cricetinae; D008647:Mesocricetus; D008854:Microscopy, Electron; D009413:Nerve Fibers, Myelinated / Q000473:pathology* / Q000648:ultrastructure; D012608:Scrapie / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure; D014855:Wallerian Degeneration / Q000473:pathology