[Correlation between expression of androgen receptors and the degree of cell differentiation in human prostate cancer].
Immunohistochemical examination was carried out to investigate androgen receptor antigen expression in epithelial cells of benign or malignant tumors in the prostate of aged men. The benign tumors were characterized by homogeneous distribution of androgen receptors in all nuclei of secretory epithelial cells. In malignant cells there was partial or complete loss of the androgen receptors to androgens in parallel with decreased cell differentiation.
Gundorova
L V
LV
Hospital for War Veterans N 2, Russian University of Peoples Friendship, Moscow.
D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011944:Receptors, Androgen / Q000096:biosynthesis*
D011944:Receptors, Androgen