[Molecular mechanisms of biological effects of lithium].
Lithium has the inhibitory effect on many enzymes and multiple effects on some physiological processes. Lithium is also highly effective in the treatment of bipolar disorder, however, the mechanism of lithium action in the treatment of this psychiatric disorder is still unknown. A number of lithium-sensitive enzymes and putative important biomolecules have been proposed as potential targets of lithium action and these mechanisms are discussed in this review.
Patocka
J
J
Katedra toxikologie, Vojenská lékarská akademie, Hradec Králové, Katedra radiologie, Zdravotnĕ sociální fakulta Jihoceské univerzity, Ceské Budĕjovice. patocka@pmfhk.cz
Klár
I
I
Strunecká
A
A
D000818:Animals; D001714:Bipolar Disorder / Q000188:drug therapy; D001921:Brain / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006003:Glycogen / Q000096:biosynthesis; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008094:Lithium / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D007294:Inositol; D006003:Glycogen; D008094:Lithium