Clinical analysis of 4 cases of juvenile granulosa cell tumor of the ovary.
OBJECTIVE
To review the diagnosis, treatment and prognosis of juvenile granulosa cell tumor of the ovary (JGCT).


METHODS
To review four patients with JGCT treated in Peking Union Medical College Hospital from 1983 to 2002.


RESULTS
JGCT is rare and most of the patients are adolescent or children. Solid pelvic mass with ascites and pleural effusion were mainly clinical feature. The levels of estrogen of the four patients were normal. Diagnoses were made by pathology. All 4 patients were at stage I and treated with surgery and combined chemotherapy. Two patients with high mitotic index progressed and died after 10 and 14 months, and the others without high mitotic index obtained a complete remission for 25 and 32 months.


CONCLUSIONS
The diagnosis of JGCT is made by pathology definitely. The prognosis is poor when patient has high mitotic index. Cytoreductive surgery is the treatment of choice and combination chemotherapy may be helpful to improve the prognosis of JGCT.
Peng
Ping
P
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Shen
Keng
K
Lang
Jinghe
J
Cui
Quancai
Q
Wu
Ming
M
D000293:Adolescent; D000068476:Beijing; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms; D011379:Prognosis