[Physiologic function of P-glycoprotein].
P-glykoprotein has been proposed to function as a membrane transport protein for a large variety of substrates, ranging from small lipophilic molecules, steroid hormones, lipophilic peptides, some drugs, biologically important molecules and xenobiotics. There is little doubt that P-glycoprotein transports a wide range of substrates out of cells, nevertheless it is difficult to explain its wide substrate specificity and mechanism of the transport. P-glycoprotein has been found to be a major cause of acquired multidrug resistance (MDR) of cancer cells to chemotherapeutic drugs. The identification and localization of P-glycoprotein expression in a variety of normal human tissues raised the question of the physiological functions of P-glykoprotein. Currently, there is considerable evidence that P-glycoprotein can protect the body and sensitive tissues against a range of different xenobiotics. In addition, P-glycoprotein might play a role in regulation of cell differentiation, proliferation, immune response and programmed cell death.
Pávek
P
P
Katedra farmakologie a toxikologie UK v Praze, Farmaceutická fakulta v Hradci Králové. pavek@faf.cuni.cz
Fendrich
Z
Z
Staud
F
F
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D018432:Drug Resistance, Multiple / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D026901:Membrane Transport Proteins