Effect of superior fiber complex on insulin sensitivity index and blood lipids in non-insulin dependent diabetes mellitus rats.
OBJECTIVE
To explore the factors affected insulin sensitivity index (ISI) and the effects of superior fiber complex (SFC) on ISI and blood lipids in non-insulin dependent diabetes mellitus (NIDDM) rats.


METHODS
Twenty-six male Wistar rats were injected with low dose of streptozotocin and fed a diet with high calorie and high fat for ten weeks and glucose tolerance (GTT), fasting insulin (FINS), total cholesterol (TC) and triglyceride (TG) were measured while area under curve (AUC) and insulin sensitivity index (ISI) were also calculated. The results were compared with those from 7 normal control rats. Multi-factor regression analysis was used to analyze those factors affected ISI. In the same experiment, 13 rats with diabetes mellitus were treated with Superior Fiber Complex (SFC) for 8 weeks and the results were compared with the pre-treated data.


RESULTS
Compared with the control group, AUC in the diabetic group was larger, and FINS, TC and TG were higher; but ISI was lower. Therefore, The TG and AUC was the major factor affected ISI. TC and TG were lowered and AUC was reduced and ISI increased.


CONCLUSIONS
High TG and impaired glucose tolerance (IGT) are main risk factors of ISI in the rat model, and SFC could increase ISI, decrease high blood lipids and prevent IGT.
Zhao
Xiaohua
X
Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Yang
Yan
Y
Song
Zheng
Z
Li
Xing
X
Li
Li
L
Zhang
Xizhong
X
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004043:Dietary Fiber / Q000627:therapeutic use*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood*
D004043:Dietary Fiber; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol