title: Changes in breast cancer incidence and stage distribution in Modena, Italy: the effect of a mammographic screening program.
abstract: OBJECTIVE
  Assessing changes in breast cancer (BC) incidence and stage distribution in the District of Modena, Italy, during the period 1992-1998, and their relationship to a mammographic screening program launched in 1995.
  
  
  METHODS
  Demographic, clinical, and pathological data of all BC cases reported to the population-based Modena Cancer Registry between 1992 and 1998 were collected and linked to the screening database.
  
  
  RESULTS
  A total of 3429 women were diagnosed with BC in the District of Modena between 1992 and 1998. In this period the incidence rate increased by 15.7% (from 134.3 in 1992 to 155.4 per 100,000 in 1998). The increase began in 1995 and exclusively included women aged 50-69; the incidence rose by 30.4%. Moreover, the rise was confined to early tumors, with more than half (54%) of all cases reported in 1998 diagnosed as stage 0 or I disease, compared with 42% in 1992. Screen-detected tumors were significantly smaller (13.2 mm) than other tumors diagnosed in women aged 50-69 (18.5 mm), with 46% of screen-detected tumors smaller than 10 mm. Overall, a decline in the average tumor diameter was shown (from 20.2 mm in 1992-1994 to 18 mm in 1996-1998).
  
  
  CONCLUSIONS
  Our data confirm that mammographic screening leads to an increase in the incidence of early-stage BC cancers.
authors.affiliation: Cattedra e Divisione di Oncologia Medica, Policlinico di Modena, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Turchetti
authors.forename: Lucia
authors.initials: L
authors.lastname: Mangone
authors.forename: Rossella
authors.initials: R
authors.lastname: Negri
authors.forename: Giulio
authors.initials: G
authors.lastname: Rossi
authors.forename: Laura
authors.initials: L
authors.lastname: Cortesi
authors.forename: Marco
authors.initials: M
authors.lastname: Vinceti
authors.forename: Antonino
authors.initials: A
authors.lastname: Maiorana
authors.forename: Ennio
authors.initials: E
authors.lastname: Gallo
authors.forename: Massimo
authors.initials: M
authors.lastname: Federico
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged