Survival signaling goes BAD.
Work published in this issue of Developmental Cell demonstrates, in vivo, that the proapoptotic gene BAD provides a genetic link between the cell death machinery and survival signaling. This work has implications for development, tissue homeostasis, and tumorigenesis.
Bergmann
Andreas
A
Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard-Unit 117, Houston, TX 77030, USA.
D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002470:Cell Survival; D004268:DNA-Binding Proteins / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology; D014157:Transcription Factors / Q000378:metabolism; D051025:bcl-Associated Death Protein
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D051025:bcl-Associated Death Protein