Human herpesvirus 7 infection impairs the survival/differentiation of megakaryocytic cells.
In vitro infection of CD61+ megakaryocytic cells with human herpesvirus-7 (HHV-7) induced a drastic increase of apoptosis. Moreover, cells surviving HHV-7 cytotoxicity showed enhanced megakaryocytic maturation with respect to control cultures. These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis.
Gonelli
Arianna
A
Mirandola
Prisco
P
Grill
Vittorio
V
Secchiero
Paola
P
Zauli
Giorgio
G
D017209:Apoptosis; D002454:Cell Differentiation; D002470:Cell Survival; D005312:Fetal Blood; D016199:Herpesvirus 7, Human / Q000502:physiology*; D006801:Humans; D008533:Megakaryocytes / Q000473:pathology / Q000821:virology*; D019349:Roseolovirus Infections / Q000473:pathology