Antidisialosyl antibodies in chronic idiopathic ataxic neuropathy.
Antidisialosyl antibodies were found in two out of 13 patients with chronic idiopathic ataxic neuropathy (CIAN) and not in 32 patients with different sensory neuropathies of known cause. This finding confirms the association of antidisialosyl antibodies and CIAN regardless of the absence of the M band. These antibodies may have pathogenic relevance; however, larger series are needed to establish their clinical significance.
Serrano-Munuera
C
C
Dept. of Neurology, Institut de Recerca, Hospital de la Sta. Creu i St. Pau, Universitat Autònoma de Barcelona, St. Antoni Ma Claret 167, Barcelona 08025, Spain.
Rojas-García
R
R
Gallardo
E
E
De Luna
N
N
Buenaventura
I
I
Ferrero
M
M
García
T
T
García-Merino
J A
JA
González-Rodríguez
C
C
Guerriero
A
A
Marco
M
M
Márquez
C
C
Grau
J M
JM
Graus
F
F
Illa
I
I
D000368:Aged; D001259:Ataxia / Q000276:immunology* / Q000503:physiopathology; D001323:Autoantibodies / Q000276:immunology* / Q000378:metabolism; D002908:Chronic Disease; D002945:Cisplatin / Q000633:toxicity; D005260:Female; D005727:Ganglia, Spinal / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D005732:Gangliosides / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009475:Neurons, Afferent / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000503:physiopathology; D012859:Sjogren's Syndrome / Q000276:immunology
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C086047:disialosyl galactosyl globoside; D002945:Cisplatin