title: Flaxseed (Linum usitatissimum) supplementation associated with reduced skin test lesional area in horses with Culicoides hypersensitivity.
abstract: The purpose of this study was to quantify the effect of flaxseed (Linum usitatissimum) supplementation on the skin test response of atopic horses. Six horses that displayed a positive skin test for allergy to extract from Culicoides sp. participated in the 42-day, placebo-controlled, double-blind, cross-over trial. Results showed that supplementation with flaxseed for 42 days in our experimental horses reduced the mean skin test response to Culicoides sp. This observation was concurrent with a significant decrease in the long-chain saturated fatty acids; behenic acid (22:0) and lignoceric acid (24:0), in the hair of horses receiving flaxseed. There was also a significant decrease in aspartate aminotransferase, and increase in serum glucose in the treatment animals at specific sampling points. It was concluded that; in this small pilot study, flaxseed was able to reduce the lesional area of the skin test response of atopic horses, alter the fatty acid profile of the hair, reduce inflammation, and did not elicit any negative side-effects in the experimental horses.
authors.affiliation: Nutraceutical Alliance, Guelph, Ontario. woneill@nutraceuticalalliance.com
authors.forename: Wendy
authors.initials: W
authors.lastname: O'Neill
authors.forename: Sharyn
authors.initials: S
authors.lastname: McKee
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Clarke
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose; D002519:Ceratopogonidae; D018592:Cross-Over Studies; D003876:Dermatitis, Atopic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005227:Fatty Acids / Q000032:analysis; D019597:Flax; D006197:Hair / Q000378:metabolism; D006734:Horse Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006736:Horses; D008517:Phytotherapy; D010865:Pilot Projects; D012882:Skin Tests / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D001219:Aspartate Aminotransferases; C007547:behenic acid; C010210:lignoceric acid