title: Potential antiamoebic property of the roots of Piper longum Linn.
abstract: In an earlier study we reported the effect of ethanol extracts of Piper longum fruit against caecal amoebiasis in rats. A follow-up study to determine whether the roots possess similar antiamoebic activity was carried out. The ethanolic extract of roots was amoebicidal at 1,000 microg/mL in vitro and cured 88% of caecal amoebiasis cases, suggesting that both the root and fruit of P. longum possess antiamoebic activity to approximately the same extent.
authors.affiliation: Division of Microbiology, Central Drug Research Institute, Lucknow - 226 001, India.
authors.forename: Sheela
authors.initials: S
authors.lastname: Ghoshal
authors.forename: V
authors.initials: V
authors.lastname: Lakshmi
mesh_terms: D000284:Administration, Oral; D000562:Amebiasis / Q000188:drug therapy*; D000563:Amebicides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004748:Entamoeba histolytica / Q000187:drug effects*; D005260:Female; D008297:Male; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D031701:Piper; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats
chemical_list: D000563:Amebicides; D010936:Plant Extracts