Mitotic regulation: the fine tuning of separase activity.
Mitotic progression requires the dissolution of cohesion between sister chromatids. Cohesion is dissolved by an essential protease known as separase. Separase is highly conserved throughout evolution and is subjected to multiple levels of regulation. Here we discuss recent studies that unravel several key mechanisms for regulating separase activity.
Agarwal
Ritu
R
The Laboratory of Molecular and Cellular Biology, NIDDK, NIH, Bethesda, Maryland 20892, USA.
Cohen-Fix
Orna
O
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology*; D020090:Chromosome Segregation; D004330:Drosophila; D029721:Drosophila Proteins; D010450:Endopeptidases; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008938:Mitosis; D064247:Separase
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D010450:Endopeptidases; C577987:ESPL1 protein, human; D064247:Separase; C577989:Sse protein, Drosophila