title: A case of hypersensitivity syndrome due to phenytoin.
abstract: We report a 30-year-old female with hypersensitivity syndrome (HS) due to phenytoin. Her disease course was typical with elevation of the antibody titer for human herpes virus 6. Three courses of methylpredonisolone pulse therapy were required to control the disease activity. Since the pathogenic mechanism and treatments for HS have not been established, further clinical analyses are warranted.
authors.affiliation: Department of Dermatology, Tone Central Hospital, Numata, Gunma, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nagai
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Hattori
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D010672:Phenytoin / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D005938:Glucocorticoids; D010672:Phenytoin; D008775:Methylprednisolone