title: A case of pulmonary adenocarcinoma accompanied by superior vena caval thrombosis in a patient with peutz-jeghers syndrome.
abstract: A case of lung adenocarcinoma and extensive deep vein thrombosis in a patient with Peutz-Jeghers syndrome (PJS) is presented. A 31-year-old Chinese man complained of shoulder pain and swelling of the right arm. A series of diagnostic procedures revealed a primary adenocarcinoma in the left upper lobe with cervical and supraclavicular lymph node metastases accompanied by deep vein thrombosis in the superior vena cava and right jugular vein. In addition, typical pigmentation of the lips and oral mucosa and multiple hamartomas in the stomach, duodenum and colon led to the diagnosis of PJS. PJS is known to be associated with increased risk of malignancies, especially in the gastrointestinal tract, breast, genitals and pancreas. As bronchoscopic examination showed no hamartomatous lesions in the bronchi, the development of primary lung cancer in this young patient might be independent of any hamartomatous lesion and might be associated with some genetic factors relating to PJS.
authors.affiliation: Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirano
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Igari
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Masato
authors.initials: M
authors.lastname: Shingyoji
authors.forename: Reiko
authors.initials: R
authors.lastname: Watanabe
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Moriya
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tanabe
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kuriyama
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000556:secondary; D000328:Adult; D020022:Genetic Predisposition to Disease; D006801:Humans; D007417:Intestinal Polyps / Q000209:etiology / Q000473:pathology; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D010580:Peutz-Jeghers Syndrome / Q000150:complications* / Q000235:genetics; D013479:Superior Vena Cava Syndrome / Q000209:etiology*