Host/pathogen interactions at mucosal surfaces: immune consequences.
The mucosal immune system has evolved to protect the host against the establishment of infections at or through the mucosal surfaces of the body. Protective immunity must be activated to specific pathogenic agents or their products but inappropriate immune responses to food/environmental antigens must be avoided. Thus, the mucosal immune system is under tight regulation. Pathogenic bacteria and their products can be exploited as specific probes of mucosal immune responses. Bacterial enterotoxins such as cholera toxin are potent mucosal immunogens and adjuvants that activate both mucosal and systemic immune responses. Infection models involving microorganisms such as Citrobacter rodentium can also be used to investigate the consequences of mucosal colonisation that lead to immune disfunction.
Clare
Simon
S
Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London, UK.
Huett
Alan
A
Dougan
Gordon
G
D000818:Animals; D016971:Citrobacter freundii / Q000472:pathogenicity*; D004195:Disease Models, Animal; D004756:Enterobacteriaceae Infections / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D051379:Mice; D009092:Mucous Membrane / Q000382:microbiology*