title: Intravenous regional anesthesia using prilocaine and neostigmine.
abstract: Neostigmine has been added to local anesthetics for central and peripheral nerve blocks resulting in prolonged, increased anesthesia and improved analgesia. We conducted this study to evaluate the effects of neostigmine when added to prilocaine for IV regional anesthesia (IVRA). Thirty patients undergoing hand surgery were randomly assigned to two groups to receive IVRA. The control group received 1 mL of saline plus 3 mg/kg of prilocaine diluted with saline to a total dose of 40 mL; the study group received 0.5 mg of neostigmine plus 3 mg/kg of prilocaine diluted with saline to a total dose of 40 mL. Sensory and motor block onset and recovery, anesthesia quality determined by an anesthesiologist, anesthesia quality determined by a surgeon, and dryness of the operative field were noted. Heart rate, mean arterial blood pressure, and oxygen saturation values were noted at 1, 5, 10, 20, and 40 min before surgery and after tourniquet release. Time to first analgesic requirement was also noted. Shortened sensory and motor block onset times, prolonged sensory and motor block recovery times, improved quality of anesthesia, and prolonged time to first analgesic requirement were found in the neostigmine group. We conclude that neostigmine as an adjunct to prilocaine improves quality of anesthesia and is beneficial in IVRA.
  
  
  CONCLUSIONS
  Neostigmine has been added to local anesthetics for central and peripheral nerve blocks. This study was conducted to evaluate the effects of neostigmine when added to prilocaine for IV regional anesthesia (IVRA). Neostigmine as an adjunct to prilocaine improves quality of anesthesia and is beneficial in IVRA.
authors.affiliation: Department of Anaesthesiology and Reanimation, Medical Faculty, Trakya University, 22030 Edirne, Turkey. alparslanturan@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Turan
authors.forename: B
authors.initials: B
authors.lastname: Karamanlýoglu
authors.forename: D
authors.initials: D
authors.lastname: Memis
authors.forename: G
authors.initials: G
authors.lastname: Kaya
authors.forename: Z
authors.initials: Z
authors.lastname: Pamukçu
mesh_terms: D000328:Adult; D000765:Anesthesia, Conduction; D000771:Anesthesia, Intravenous; D000779:Anesthetics, Local; D001794:Blood Pressure / Q000187:drug effects; D002800:Cholinesterase Inhibitors; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009388:Neostigmine; D009407:Nerve Block; D010100:Oxygen / Q000097:blood; D011318:Prilocaine
chemical_list: D000779:Anesthetics, Local; D002800:Cholinesterase Inhibitors; D011318:Prilocaine; D009388:Neostigmine; D010100:Oxygen