Electrochemical behaviour and determination of acrivastine in pharmaceuticals and human urine.
The differential pulse polarography, DC-tast polarography and cyclic voltammetry behaviour of acrivastine was studied in Britton-Robinson buffer solutions (pH 2-11.7). In acidic media, a non-reversible diffusion controlled reduction process involving four electrons takes place. Two reduction waves appear at a E(1/2)=-0.6 and -0.99 V. The reduction mechanism is discussed. The linear relationship between peak current height and acrivastine concentration allowed the differential pulse polarographic determination of acrivastine over a wide concentration range, from 0.35 to 26.1 mg l(-1)at pH 2.5. The procedure was applied to determination of the drug in pharmaceutical formulations and human urine samples.
Fernández Torres
R
R
Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, E-41002, Seville, Spain.
Callejón Mochón
M
M
Jiménez Sánchez
J C
JC
Bello López
M A
MA
Guiraúm Perez
A
A
D004563:Electrochemistry; D006801:Humans; D004364:Pharmaceutical Preparations; D014311:Triprolidine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry* / Q000652:urine*
D004364:Pharmaceutical Preparations; D014311:Triprolidine; C043648:acrivastine