title: Bilateral symmetry of human carotid artery atherosclerosis.
abstract: OBJECTIVE
  Atherosclerosis is a principal cause of stroke and myocardial infarction. The carotid arteries provide a site at which progression of atherosclerosis can be monitored reproducibly and noninvasively. This study was conducted to determine the similarity of atherosclerotic plaques in the left and right carotid arteries. This question was explored with the use of perfusion-fixed cadaveric carotid arteries and 2 noninvasive clinical imaging techniques, MRI and electron-beam CT.
  
  
  METHODS
  Fifty pairs of carotid arteries from cadaveric donors (aged 48 to 98 years) were imaged with MRI and electron-beam CT. Thirty-eight of the pairs met the criteria for rigorous analysis. Carotid artery wall volumes were measured from the MRI images, and calcification scores were computed from the electron-beam CT images.
  
  
  RESULTS
  Total wall volumes of the left (972.5+/-241.6 mm3) and right (1016.3+/-275.0 mm3) carotid arteries were moderately correlated (concordance correlation coefficient [r(c)]=0.71). Calcification scores were highly correlated, with r(c)=0.95 for the Agatston scores and r(c)=0.94 for the calcium volume scores.
  
  
  CONCLUSIONS
  Total wall volume and plaque calcification in the left and right human carotid arteries are substantially similar. These results suggest that atherosclerosis of the human carotid arteries is generally a bilaterally symmetrical disease. This evidence of symmetry suggests that diagnostic information about atherosclerotic plaque in one carotid artery can be used to infer information about the composition and volume of atherosclerotic plaque in the contralateral artery.
authors.affiliation: Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, Houston, Tex 77030, USA.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Adams
authors.forename: Darlene M
authors.initials: DM
authors.lastname: Simoni
authors.forename: Cassius B
authors.initials: CB
authors.lastname: Bordelon
authors.forename: G Wesley
authors.initials: GW
authors.lastname: Vick
authors.forename: Kay T
authors.initials: KT
authors.lastname: Kimball
authors.forename: William
authors.initials: W
authors.lastname: Insull
authors.forename: Joel D
authors.initials: JD
authors.lastname: Morrisett
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed