Cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs.
OBJECTIVE
To evaluate efficacy and cost of using cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs.


METHODS
Clinical trial.


METHODS
12 dogs with perianal fistulas.


METHODS
Dogs received cyclosporine and ketoconazole orally (target whole blood trough cyclosporine concentrations of 400 to 600 ng/ml). Study endpoints were resolution of clinical signs, remission, and recurrence of disease. Adverse effects and cost of medications were reported. Results were compared with those from previous studies in humans and in dogs in which single agent cyclosporine treatment for perianal fistulas was used.


RESULTS
All dogs had resolution of clinical signs. Eight dogs went into remission; however, 5 of those 8 had recurrence of fistulas. Adverse effects of treatment were minimal and well tolerated. Cost of treatment was comparable to traditional surgical options and less than single agent cyclosporine treatment.


CONCLUSIONS
Administration of cyclosporine with ketoconazole is an effective and cost-comparable treatment for perianal fistulas in dogs.
Patricelli
Alison J
AJ
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 53762, USA.
Hardie
Robert J
RJ
McAnulty
Jonathan E
JE
D000284:Administration, Oral; D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D007654:Ketoconazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D008297:Male; D010481:Perianal Glands; D012003:Rectal Fistula / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D012008:Recurrence; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D007654:Ketoconazole