The effect of para-aminobenzoic acid on growth and metabolism of Porphyromonas gingivalis.
OBJECTIVE
To study the effect of para-aminobenzoic acid (PABA) on the growth and metabolism of Porphyromonas gingivalis (P.g).


METHODS
After adding different concentrations of PABA into the medium, anaerobic technique was applied to culture P.g. The products' A value and action of TLP was assayed, and P.g grew in the medium was observed by a scanning electron microscope.


RESULTS
PABA promoted the growth of P.g and action of TLP, which would reach the highest level when PABA was 1 mg/L, and would decrease with the increasing of concentration of PABA. When the concentration arrived at 100 mg/L, PABA had no effect on them. In the mean time, PABA had effect on the form and adherence of P.g. When the concentration was 1 mg/L and 100 mg/L, this effect was strong, but as the concentration was 10 mg/L, the effect disappeared.


CONCLUSIONS
PABA influences the growth and metabolism of P.g, which indicate that Streptococcus sanguis has regulative effect on the microecology of subgingival plaque.
Zhou
Xuedong
X
Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Wang
Zhiling
Z
Li
Jiyao
J
Xiao
Xiaorong
X
Hu
Tao
T
D010129:4-Aminobenzoic Acid; D003773:Dental Plaque; D016966:Porphyromonas gingivalis / Q000378:metabolism; D013298:Streptococcus sanguis
D010129:4-Aminobenzoic Acid