Cannabidiol: an overview of some pharmacological aspects.
Over the past few years, considerable attention has focused on cannabidiol (CBD), a major nonpsychotropic constituent of cannabis. The authors present a review on the chemistry of CBD and discuss the anticonvulsive, antianxiety, antipsychotic, antinausea, and antirheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors, and its mechanism of action is yet unknown. It is possible that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its antioxidative effect.
Mechoulam
Raphael
R
Deportment of Medicinal Chemistry and Natural Products, Hebrew University of Jerusalem, Israel.
Parker
Linda A
LA
Gallily
Ruth
R
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D000932:Antiemetics / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D002185:Cannabidiol / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D009325:Nausea / Q000517:prevention & control
D014151:Anti-Anxiety Agents; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000932:Antiemetics; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D002185:Cannabidiol