Evidence for the efficacy of artesunate in asymptomatic Plasmodium malariae infections.
This study evaluated the efficacy and safety of a 3-day course of artesunate (4 mg/kg/day) for asymptomatic Plasmodium malariae infections. The parasitological cure rates on days 7 and 56 in the group treated with artesunate were 100% and 83%, respectively, compared with no cure in the placebo group (P < 0.0001).
Borrmann
Steffen
S
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, B P 118, Gabon. steffen.borrmann@uni-tuebingen.de
Szlezák
Nicole
N
Binder
Ronald K
RK
Missinou
Michel A
MA
Lell
Bertrand
B
Kremsner
Peter G
PG
D000293:Adolescent; D000818:Animals; D037621:Artemisinins / Q000494:pharmacology / Q000627:therapeutic use*; D000077332:Artesunate; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy*; D008297:Male; D010965:Plasmodium malariae / Q000187:drug effects; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*
D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate