Estrogen and cognitive aging in women.
The steady increase in female life expectancy has attracted attention to the importance of preventing cognitive aging and Alzheimer's disease (AD) in women. Evidence from randomized, controlled trials and from cross-sectional and longitudinal studies shows that estrogen-replacement therapy preferentially protects against a decline in verbal memory in healthy postmenopausal women and decreases the risk of AD. Although results are not consistent across studies, they indicate that treatment with estrogen during the postmenopausal years might protect against cognitive aging in women during the latter part of their life.
Sherwin
Barbara B
BB
McGill University, Dept of Psychology, 1205 Dr Penfield Ave, Quebec, H3X 1B1, Montreal, Canada. bsherwin@ego.psych.mcgill.ca
D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000517:prevention & control*; D003072:Cognition Disorders / Q000517:prevention & control*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D017698:Postmenopause; D016032:Randomized Controlled Trials as Topic; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
D020845:Selective Estrogen Receptor Modulators