Constituents of holothuroidea, 12. Isolation and structure of glucocerebrosides from the sea cucumber Holothuria pervicax.
Ten glucocerebrosides, HPC-3-A-HPC-3-J, have been isolated from their obtained parent glucocerebroside molecular species HPC-3, together with other glucocerebroside molecular species HPC-1 and HPC-2, from the less polar lipid fraction of a chloroform/methanol extract of the sea cucumber Holothuria pervicax. The structures of these glucocerebrosides have been determined on the basis of chemical and spectroscopic evidence. Reversed-phase HPLC, including a recycling system, was effective in isolating these glucocerebrosides, revealing a very close resemblance in structure, though the problem due to regio-isomers remains.
Yamada
Koji
K
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Sasaki
Kaori
K
Harada
Yasuo
Y
Isobe
Ryuichi
R
Higuchi
Ryuichi
R
D000818:Animals; D005963:Glucosylceramides / Q000737:chemistry* / Q000302:isolation & purification*; D012616:Sea Cucumbers
D005963:Glucosylceramides