Two new prosapogenins from Albizia adianthifolia.
Two new triterpenoidal prosapogenins 1 and 2 were obtained from the mild alkaline hydrolysate of the crude saponin fraction of Albizia adianthifolia (Mimosaceae) roots. Their structures were mainly determined by spectral analyses as acacic acid 3-O-beta-D-xylopyranosyl-(1-->2)-beta-D-fucopyranosyl-(1-->6)- 2-acetylamino-2-deoxy-beta-D-glucopyranoside (1) and acacic acid 3-O-(beta-D-xylopyranosyl-(1-->2)-beta-D-fucopyranosyl-(1-->6)- [beta-D-glucopyranosyl-(1-->2)]-beta-D-glucopyranosyl)-21-O-(6(S)-2- hydroxymethyl-6-methyl-6-O-(beta-D-quinovopyranosyl)-2,7-octadienoyl) ester (2). Furthermore, the known julibroside A3 was isolated from the crude saponin mixture. Compounds 1 and 2 did not show any ability to potentiate in vitro cisplatin cytotoxicity in a human colon cancer cell line.
Haddad
M
M
Laboratoire de Pharmacognosie, Unité MIB JE 2244, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
Khan
I A
IA
Lacaille-Dubois
M A
MA
D000349:Africa; D031289:Albizzia / Q000737:chemistry*; D002853:Chromatography, Liquid; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
D010936:Plant Extracts; D014315:Triterpenes; C468954:prosapogenin 1; C468955:prosapogenin 2