Psychopharmacological profiles of Leucas Lavandulaefolia Rees.
Methanol extract of Leucas lavandulaefolia (LLFE) was evaluated for different psychopharmacological profiles with various animal models in rats and mice. The extract showed a potential reduction in spontaneous activity and caused a significant decrease in exploratory behavioural pattern by the head dip and Y-maze test. It also showed a significant reduction in muscle relaxant activity by rotarod, 30 degrees inclined screen and traction tests. The extract showed a remarkable potentiation of pentobarbitone induced sleeping time in mice.
Mukherjee
Kakali
K
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta - 700032, India. mukherjeepk@rediffmail.com
Saha
B P
BP
Mukherjee
Pulok K
PK
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D019686:Lamiaceae; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010424:Pentobarbital; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012890:Sleep / Q000187:drug effects
D014151:Anti-Anxiety Agents; D009465:Neuromuscular Agents; D010936:Plant Extracts; D010424:Pentobarbital