A novel silver(i)-mediated DNA base pair.
We have generated a novel silver(I)-mediated unnatural DNA base pair consisting of two 2,6-bis(ethylthiomethyl)pyridine nucleobases SPy. This metallo-base pair has a remarkably high pairing stability and selectivity which rivals that of the natural base pairs dA:dT and dC:dG. UV-melting experiments revealed that the dSPy:dSPy self-pair can replace natural base pairs at multiple sites and still form stable DNA duplexes.
Zimmermann
Nicole
N
The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Meggers
Eric
E
Schultz
Peter G
PG
D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
C470606:2,6-bis(ethylthiomethyl)pyridine; D011725:Pyridines; D012834:Silver; D004247:DNA