title: Structural studies on rhodopsin.
abstract: Bovine rhodopsin is the prototypical G protein coupled receptor (GPCR). It was the first GPCR to be obtained in quantity and studied in detail. It is also the first GPCR for which detailed three dimensional structural information has been obtained. Reviewed here are the experiments leading up to the high resolution structure determination of rhodopsin and the most recent structural information on the activation and stability of this integral membrane protein.
authors.affiliation: Department of Molecular and Cell Biology, U-125 University of Connecticut, 75 North Eagleville Road, Storrs, CT 06269-3125, USA.
authors.forename: Arlene D
authors.initials: AD
authors.lastname: Albert
authors.forename: Philip L
authors.initials: PL
authors.lastname: Yeagle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D003593:Cytoplasm / Q000737:chemistry; D003623:Dark Adaptation; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins / Q000737:chemistry* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012172:Retinaldehyde / Q000737:chemistry; D012243:Rhodopsin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000502:physiology
chemical_list: D008565:Membrane Proteins; C013110:metarhodopsins; D012243:Rhodopsin; D012172:Retinaldehyde