title: Primary intracranial fibrosarcoma.
abstract: BACKGROUND
  Primary fibrosarcomas of the brain are very rare tumors, so that information regarding the treatment is scarce. We report the contributions that different therapeutic options made to the treatment of a child with one of these aggressive tumors.
  
  
  METHODS
  A 13-year-old boy underwent a complete resection of a left temporo-parietal mass that had been diagnosed as a fibrosarcoma by two independent pathologists. Adjuvant chemotherapy with vincristine, actinomycin-D, ifosfamide and Adriamycin was started, but after 3 months tumor relapse was evident. The boy subsequently received radiation therapy during which there was evidence of progressive tumor shrinkage. A second surgery was performed 6 months after radiotherapy and a small enhancing lesion, revealed to be gliosis, was resected. The child remains alive and well 44 months after diagnosis.
  
  
  CONCLUSIONS
  Our experience supports the importance of total resection followed by radiation therapy, and radiotherapy should be started as soon as possible after surgical resection, rather than administering chemotherapy first.
authors.affiliation: Hematology/Oncology Division, Department of Pediatrics, Via Giustiniani, 3, 35128 Padua, Italy. gianni.bisogno@unipd.it
authors.forename: Gianni
authors.initials: G
authors.lastname: Bisogno
authors.forename: Jelena
authors.initials: J
authors.lastname: Roganovic
authors.forename: Modesto
authors.initials: M
authors.lastname: Carli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scarzello
authors.forename: Milena
authors.initials: M
authors.lastname: Calderone
authors.forename: Roberto
authors.initials: R
authors.lastname: Faggin
authors.forename: Giorgio
authors.initials: G
authors.lastname: Perilongo
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005354:Fibrosarcoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005911:Gliosis / Q000601:surgery; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents