title: Induction of homosynaptic long-term depression in entorhinal cortex.
abstract: Prolonged low frequency stimulation (1 Hz, 15 min) induced significant long-term depression (LTD) in hippocampal CA1 region and superficial, but not deep, layers of rat medial entorhinal cortex (EC) in vitro. In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not in CA1 or EC deep layers. These results show differences in characteristics of LTD induction across CA1, EC superficial layers, and EC deep layers.
authors.affiliation: Institute for Medical Sciences, Ajou University School of Medicine, Suwon 442-721, South Korea.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Cheong
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Yun
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-Jung
authors.forename: Yup
authors.initials: Y
authors.lastname: Kang
authors.forename: Min Whan
authors.initials: MW
authors.lastname: Jung
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D004594:Electrophysiology; D018728:Entorhinal Cortex / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000187:drug effects; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate