title: Mixed malignant germ cell tumour of the lateral ventricle in an 8-month-old girl: case report and review of the literature.
abstract: METHODS
  We report a huge intracerebral malignant germ cell tumour (GCT) which appeared in the lateral ventricles of an 8-month-old girl. Due to extensive tumour vascularisation only partial resection was achieved. Histology revealed an embryonal carcinoma mixed with a teratoma. The MIB-1 staining index was >20%. Chemotherapy induced a marked regression of the tumour. After chemotherapy complete resection of the tumour remnant was easily achieved. Histology showed only mesenchymal differentiated tumour tissue and the embryonal carcinoma could no longer be detected. More than 2 years after the second operation and 31 months after diagnosis the child remains tumour-free.
  
  
  CONCLUSIONS
  The majority of cranial mixed malignant GCTs affects patients older than 4 years of age. To our knowledge this is the youngest patient in whom an intracranial malignant GCT containing an embryonal carcinoma has been diagnosed and successfully treated.
authors.affiliation: Department of Neurosurgery, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377 Munich, Germany. cgoetz@nc.med.uni-muenchen.de
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Goetz
authors.forename: Irene
authors.initials: I
authors.lastname: Schmid
authors.forename: Thorsten
authors.initials: T
authors.lastname: Pietsch
authors.forename: Aurelia
authors.initials: A
authors.lastname: Peraud
authors.forename: R J
authors.initials: RJ
authors.lastname: Haas
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D020547:Lateral Ventricles / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D018365:Neoplasm, Residual; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D012086:Reoperation; D016896:Treatment Outcome