Modification of post-PKS tailoring steps through combinatorial biosynthesis.
This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases. ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.
Rix
Uwe
U
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
Fischer
Carsten
C
Remsing
Lily L
LL
Rohr
Jürgen
J
D000595:Amino Acid Sequence; D000818:Animals; D020650:Combinatorial Chemistry Techniques; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000096:biosynthesis / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D010088:Oxidoreductases; D014166:Transferases / Q000378:metabolism
D009097:Multienzyme Complexes; D010088:Oxidoreductases; D014166:Transferases