Phosphorus metabolite changes in temporal lobes of subjects with schizotypal personality disorder.
Using in vivo (31)P magnetic resonance spectroscopy, phosphorus metabolite levels were measured in the temporal lobes of 11 neuroleptic-free subjects with schizotypal personality disorder (SPD) and 20 age-matched healthy subjects. SPD subjects showed smaller amounts of phosphomonoesters in the left temporal lobe than healthy subjects. Membrane phospholipid abnormalities in the left temporal lobe may be a common pathophysiologic feature in schizophrenia spectrum disorders.
Fukuzako
Hiroshi
H
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan. fukuzako@m2.kufm.kagoshima-u.ac.jp
Kodama
Satoshi
S
Fukuzako
Tsuyoshi
T
D000328:Adult; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D012569:Schizotypal Personality Disorder / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
D010758:Phosphorus