title: Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2.
abstract: Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.
authors.affiliation: Department of Molecular Biosciences, The University of Adelaide, SA 5005, Australia. casper.groth@adelaide.edu.au
authors.forename: Casper
authors.initials: C
authors.lastname: Groth
authors.forename: Svanhild
authors.initials: S
authors.lastname: Nornes
authors.forename: Rosa
authors.initials: R
authors.lastname: McCarty
authors.forename: Richard
authors.initials: R
authors.lastname: Tamme
authors.forename: Michael
authors.initials: M
authors.lastname: Lardelli
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D015153:Blotting, Western; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008544:Melanocytes / Q000166:cytology / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D009432:Neural Crest; D010802:Phylogeny; D053766:Presenilin-2; D017386:Sequence Homology, Amino Acid; D015027:Zebrafish / Q000196:embryology / Q000235:genetics* / Q000254:growth & development
chemical_list: D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2