title: Analgesic principle from the bark of Careya arborea.
abstract: Bioactivity guided isolation of the bark of Careya arborea afforded piperine--an alkaloid chemically known as 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine, which was found to possess significant central and peripheral analgesic activity. At oral doses of 10, 20 and 30 mg/kg body weight, piperine exhibited 41 (p < 0.01), 45 (p < 0.01) and 53% (p < 0.001) inhibition of acetic acid induced writhing in mice respectively. At doses of 20 and 30 mg/kg body weight, the compound also showed 31.8 (p < 0.05) and 52.4% (p < 0.01) prolongation of tail flicking time of mice 30 min after the treatments determined by the radiant heat method.
authors.affiliation: Pharmacology Research Laboratory, Department of Pharmacy, University of Dhaka, Bangladesh. pharmacy@dhaka.net
authors.forename: M
authors.initials: M
authors.lastname: Ahmed
authors.forename: M W
authors.initials: MW
authors.lastname: Rahman
authors.forename: M T
authors.initials: MT
authors.lastname: Rahman
authors.forename: C F
authors.initials: CF
authors.lastname: Hossain
mesh_terms: D019342:Acetic Acid; D000470:Alkaloids; D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001459:Bangladesh; D001522:Behavior, Animal / Q000187:drug effects; D052117:Benzodioxoles; D005260:Female; D031381:Lecythidaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D053284:Polyunsaturated Alkamides; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052117:Benzodioxoles; D010880:Piperidines; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; D019342:Acetic Acid; C008922:piperine