DNA-lipid interactions in vitro and in vivo.
The data on lipid-nucleic interactions and their role in vitro and in vivo are presented. The results of study of DNA-lipid complexes in absence and in presence of divalent metal cations (triple complexes) are discussed. The triple complexes represent the generation of cellular structures such as pore complexes of eucaryotes and "Bayer's junctions" of procaryotes. The participation of triple complexes in the formation of structure of bacterial and eucaryotic nucleoid and nuclear matrix is analysed. A model of formation of triple complexes and cellular structures and their role in DNA-lipid interactions are discussed.
Kuvichkin
V V
VV
Laboratory of Reception Mechanisms Biophysics, Institute of Cell Biophysics of Russian Academy of Sciences, 142290 Moscow Region, Pushkino, Russia. vkuv@rambler.ru
D000818:Animals; D002412:Cations; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004269:DNA, Bacterial / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008081:Liposomes; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism
D002412:Cations; D002843:Chromatin; D004269:DNA, Bacterial; D008055:Lipids; D008081:Liposomes; D008563:Membrane Lipids; D004247:DNA