Gene expression profiles--a new dynamic and functional dimension to the exploration of learning and memory.
Many experiments in the past have demonstrated the requirement of de novo gene expression during the long-term retention of learning and memory. Although previous studies implicated individual genes or genetic pathways in learning and memory they did not uncover the collective behaviors of the genes. In view of the broad variety of genes and the cross-talk of genetic pathways, gene expression profiles offer a new dynamic and functional dimension to the exploration of learning and memory. This review illustrates how DNA microarray-based gene expression profiling may help to dissect and analyze the complex mechanisms involved in gene regulation during the acquisition and storage of memory.
D'Agata
Velia
V
Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, MD 20850, USA.
Cavallaro
Sebastiano
S
D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism; D003213:Conditioning, Psychological; D015870:Gene Expression / Q000502:physiology*; D020869:Gene Expression Profiling; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
C491123:BACH2 protein, human; D050976:Basic-Leucine Zipper Transcription Factors; D014157:Transcription Factors; D007334:Insulin-Like Growth Factor I