title: Diabetes mellitus associated with Klinefelter's syndrome: a case report and review in Japan.
abstract: We report a case of Klinefelter's syndrome in a 48-year-old man who had diabetes mellitus associated with severe insulin resistance. We diagnosed him with Klinefelter's syndrome from his atrophic testicles, primary hypogonadism in hormonal examination, and a chromosomal aberration of 47,XXY. He showed severe decreased insulin sensitivity in a hyper-insulinemic euglycemic clamp test. He had injected over 100 units of insulin per day, however, testosterone replacement and administration of pioglitazone improved his glycemic control, which resulted in a decrease of insulin dose to less than 50 units per day. Here, we discuss the characteristics of diabetes mellitus associated with Klinefelter's syndrome in Japanese patients including this case.
authors.affiliation: Second Department of Internal Medicine, Kochi Medical School.
authors.forename: Kikuko
authors.initials: K
authors.lastname: Ota
authors.forename: Tadashi
authors.initials: T
authors.lastname: Suehiro
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Arii
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kumon
authors.forename: Kozo
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D001786:Blood Glucose; D041321:Chromosomes, Human, X; D003920:Diabetes Mellitus / Q000209:etiology* / Q000628:therapy; D003940:Diagnostic Techniques, Endocrine; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007564:Japan; D007713:Klinefelter Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012729:Sex Chromosome Aberrations
chemical_list: D001786:Blood Glucose; D007328:Insulin