title: The relativity between Streptococcus sanguis group and coronary heart disease.
abstract: OBJECTIVE
  To study the relativity between Streptococcus sanguis group (SSG) and coronary heart disease (CHD).
  
  
  METHODS
  41 individuals were diagnosed with CHD and 18 normals served as controls. All of them had undergone coronary angiography. Their social class (including education and wages), smoking, drinking, blood lipids and oral health were also recorded. SSG in saliva and subgingival plaque were cultivated in NAYS-B agar plates and counted. SSG were identified into species with routine biochemical reaction and AP-PCR.
  
  
  RESULTS
  In the multiple step regression analysis, the amount of SSG in saliva and subgingival plaque were positively associated with severe coronary atheromatosis after adjusting the classical risk factors of CHD. The average amount of SSG in saliva was (435 +/- 422) x 10(8) CFU/L in CHD group and (358 +/- 540) x 10(8) CFU/L in control group, F = 2.72, P = 0.08; the average amount of SSG in incisor was (331 +/- 484) x 10(7) CFU/L in CHD group and (98 +/- 164) x 10(7) CFU/L in control group, F = 5.54, P = 0.02; the average amount of SSG in molar was (352 +/- 381) x 10(7) CFU/L in CHD group and (185 +/- 232) x 10(7) CFU/L in control group, F = 2.86, P = 0.10. S. sanguis and S. gordonii were more in CHD group than in control group (P < 0.05), whereas S. mitis and S. oralis were the same in two groups (P > 0.05).
  
  
  CONCLUSIONS
  The increase of SSG in oral floras may play an important role in the occurrence of CHD.
authors.affiliation: Department of Oral Medicine, The Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Shuli
authors.initials: S
authors.lastname: Deng
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000150:complications*; D003773:Dental Plaque / Q000382:microbiology; D004522:Educational Status; D005881:Gingiva / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D008963:Molar / Q000382:microbiology; D012307:Risk Factors; D012463:Saliva / Q000382:microbiology; D012907:Smoking; D012959:Socioeconomic Factors; D013223:Statistics as Topic; D013290:Streptococcal Infections / Q000150:complications* / Q000382:microbiology; D013298:Streptococcus sanguis / Q000302:isolation & purification*