Trypanocidal terpenoids from Laurus nobilis L.
Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 microM, respectively.
Uchiyama
Nahoko
N
Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
Matsunaga
Keiji
K
Kiuchi
Fumiyuki
F
Honda
Gisho
G
Tsubouchi
Akiko
A
Nakajima-Shimada
Junko
J
Aoki
Takashi
T
D000818:Animals; D006367:HeLa Cells; D006801:Humans; D027442:Laurus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D010936:Plant Extracts; D013729:Terpenes; D014344:Trypanocidal Agents