Dehydrogenases, NAD, and transcription--what's the connection?
In the October issue of Molecular Cell, Kumar et al. demonstrate that the C-terminal binding protein (CtBP) is an NAD-dependent dehydrogenase that links enzymatic activity to protein-protein contacts associated with transcriptional repression, and implicates a broader involvement of enzymes and NAD in the regulation of gene expression.
Marmorstein
Ronen
R
The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
D000429:Alcohol Oxidoreductases; D004268:DNA-Binding Proteins / Q000737:chemistry*; D005786:Gene Expression Regulation; D008958:Models, Molecular; D009243:NAD / Q000737:chemistry*; D010088:Oxidoreductases / Q000737:chemistry*; D010750:Phosphoproteins / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D009243:NAD; D012313:RNA; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; C096794:C-terminal binding protein