title: Indocyanine green angiography in Bietti's crystalline retinopathy.
abstract: BACKGROUND
  To our knowledge, the indocyanine green (ICG) angiographic features of Bietti's crystalline retinopathy have been described in a single case only. We report the ICG angiographic findings in four patients with Bietti's crystalline retinopathy and compare them with the fluorescein angiographic findings.
  
  
  METHODS
  Review of the records of four patients with Bietti's crystalline retinopathy, three of whom were from a single consanguineous family. Fluorescein and ICG angiography were performed with the Heidelberg scanning laser ophthalmoscope.
  
  
  RESULTS
  The ICG angiographic findings varied according to the stage of the disease. In the early stages no retinal pigment epithelium (RPE) alterations or choriocapillaris loss were noted. In advanced cases there was extensive chorioretinal atrophy. Most notably, intraretinal crystals did not exhibit fluorescence/cyanescence and had no masking effect on fluorescein or ICG angiography. In all cases angiography showed hypofluorescent/hypocyanescent dots, most likely corresponding to RPE alterations adjacent to atrophic areas.
  
  
  CONCLUSIONS
  ICG angiography does not give additional information in Bietti's crystalline retinopathy and probably is not superior to fluorescein angiography. However, it delineates the atrophic areas slightly better than does fluorescein angiography.
authors.affiliation: Department of Ophthalmology, Dokuz Eylül University, Izmir, Turkey. o.saatci@unimedya.net.tr
authors.forename: A Osman
authors.initials: AO
authors.lastname: Saatci
authors.forename: Aylin
authors.initials: A
authors.lastname: Yaman
authors.forename: F Hakan
authors.initials: FH
authors.lastname: Oner
authors.forename: Mehmet H
authors.initials: MH
authors.lastname: Ergin
authors.forename: Güray
authors.initials: G
authors.lastname: Cingil
mesh_terms: D000293:Adolescent; D001284:Atrophy; D002829:Choroid / Q000473:pathology; D004396:Coloring Agents; D003460:Crystallization; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green