title: Pulmonary metastasectomy for 165 patients with colorectal carcinoma: A prognostic assessment.
abstract: OBJECTIVE
  The purpose of this study was to analyze our entire experience with pulmonary resection for metastatic colorectal carcinoma to determine prognostic factors and critically evaluate the potential role of extended metastasectomy.
  
  
  METHODS
  We analyzed the postoperative survival of 165 patients who underwent curative pulmonary surgery at eight institutions in the Kansai region of western Japan (Kansai Clinical Oncology Group) from 1990 to 2000.
  
  
  RESULTS
  Overall survivals at 5 and 10 years were 39.6% and 37.2%, respectively. Cumulative survival of patients who underwent simultaneous bilateral metastasectomy was significantly lower than that of the patients who underwent unilateral metastasectomy or sequential bilateral metastasectomy (P =.048). Five-year survival was 53.6% for patients without hilar or mediastinal lymph node metastasis, versus 6.2% at 4 years for patients with metastases (P <.001). Five-year survival of patients with a prethoracotomy carcinoembryonic antigen level less than 10 ng/mL was 42.7%, versus 15.1% at 4 years for patients with a carcinoembryonic antigen level 10 ng/mL or greater (P <.0001). Twenty-one patients underwent a second or third thoracotomy for recurrent colorectal carcinoma. Overall 5-year survival from the date of the second thoracotomy was 52.1%. The 34.1% 10-year survival for the 26 patients with hepatic metastasis resected before thoracotomy did not differ significantly from that of patients without hepatic metastases (P =.38).
  
  
  CONCLUSIONS
  The status of the hilar or mediastinal lymph nodes and prethoracotomy carcinoembryonic antigen level were significant independent prognostic factors. Patients with pulmonary metastases potentially benefit from pulmonary metastasectomy even when there is a history of solitary liver metastasis. Careful follow-up is warranted, because patients with recurrent pulmonary metastases can undergo repeat thoracotomy with acceptable long-term survival. Simultaneous bilateral metastasectomy confers no survival benefit. Prospective studies may determine the significance of this type of pulmonary metastasectomy.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Moriguchi, Japan. saitoy@takii.kmu.ac.jp
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Saito
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Omiya
authors.forename: Keijiro
authors.initials: K
authors.lastname: Kohno
authors.forename: Takanobu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kazumi
authors.initials: K
authors.lastname: Itoi
authors.forename: Masami
authors.initials: M
authors.lastname: Teramachi
authors.forename: Masato
authors.initials: M
authors.lastname: Sasaki
authors.forename: Hitoyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Hitoji
authors.initials: H
authors.lastname: Takao
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nakade
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D011013:Pneumonectomy; D011379:Prognosis; D012086:Reoperation; D016019:Survival Analysis; D013908:Thoracotomy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen