title: Biological activity of Manduca sexta allatotropin-like peptides, predicted products of tissue-specific and developmentally regulated alternatively spliced mRNAs.
abstract: The insect neuropeptide, allatotropin (Manse-AT), exerts multiple functions including the stimulation of juvenile hormone (JH) biosynthesis in adults and the inhibition of active ion transport across the midgut epithelium of feeding larvae. The Manse-AT gene is expressed in multiple regions of the nervous system as three mRNAs that differ by alternative splicing. The specific mRNA isoform present differs in a tissue- and developmental-specific manner thus providing a mechanism for the regulated production of peptides specific to each isoform. These peptides are predicted to include three allatotropin-like (Manse-ATL) peptides that exhibit limited structural identity to Manse-AT and overlapping biological activities.
authors.affiliation: Department of Biomedical Sciences and the College of Osteopathic Medicine, 228 Irvine Hall, Ohio University, Athens 45701, USA.
authors.forename: Kyeong-Yeoll
authors.initials: KY
authors.lastname: Lee
authors.forename: Mary E
authors.initials: ME
authors.lastname: Chamberlin
authors.forename: Frank M
authors.initials: FM
authors.lastname: Horodyski
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D007301:Insect Hormones / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D018402:Manduca; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D007301:Insect Hormones; D009479:Neuropeptides; D012333:RNA, Messenger; C050669:allatotropin