A new dipeptide, O-phosphoserylethanolamine isolated from Agkistroden blomhoffi (mamushi).
A new dipeptide was isolated from several tissues of Agkistroden blomhoffi (mamushi: a venomous snake in Japan), using ion-exchange resins and thin-layer chromatography. It was identified as O-phosphoserylethanolamine by mass spectrometry and comparison with synthetic compounds using several methods. This compound was contained in several mamushi tissues including the liver, heart, brain, bile, and muscle. The concentrations of O-phosphoserylethanolamine in the liver, brain, muscle, skin, heart, and bile were 7.17+/-3.11,16.98+/-4.25,37.37+/-7.88,37.56+/-8.97,23.93+/-6.11, and 22.21+/-5.76 micromol/g, respectively.
Masuoka
Noriyoshi
N
Department of Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
Zhang
Jianying
J
Partoo
Leila
L
Ohta
Jun
J
Sasaki
Kenji
K
Ebinuma
Hideo
H
Kodama
Hiroyuki
H
D017836:Agkistrodon; D000818:Animals; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004151:Dipeptides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D004983:Ethanolamines / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D013058:Mass Spectrometry; D010768:Phosphoserine / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D014018:Tissue Distribution
D004151:Dipeptides; D004983:Ethanolamines; C469229:O-phosphoserylethanolamine; D010768:Phosphoserine