Case report. Severe cutaneous ulceration secondary to cytomegalovirus inclusion disease during successful immune reconstitution with HAART.
Restoration of the immune system following HAART is not without its adverse effects. We describe a case of severe cutaneous ulceration secondary to cytomegalovirus (CMV) infection in an HIV-1-seropositive man following the initiation of HAART in the absence of active CMV retinitis and discuss the likely mechanisms associated with its development.
Qazi
Nadeem A
NA
Kobler Clinic, St. Stephen's Centre, Chelsea & Westminster Hospital, London, UK.
Morlese
John F
JF
Walsh
John C
JC
Bunker
Christopher B
CB
Francis
Nicholas
N
Nelson
Mark R
MR
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D017193:Skin Diseases, Viral / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology*