Grafting of synthetic mannose receptor-ligands onto onion vectors for human dendritic cells targeting.
A practical preparation of onion vesicles targeted to dendritic cells involves the grafting of mannose-mimetic clusters, bearing a hydrazino group, onto the surface of onion vesicles containing an aldehyde functionalized lipid.
Chenevier
Pascale
P
CRPP, CNRS 8641, Pessac, Université de Bordeaux 1, France.
Grandjean
Cyrille
C
Loing
Estelle
E
Malingue
Frédéric
F
Angyalosi
Gerhild
G
Gras-Masse
Hélène
H
Roux
Didier
D
Melnyk
Oleg
O
Bourel-Bonnet
Line
L
D020650:Combinatorial Chemistry Techniques; D003713:Dendritic Cells / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D008024:Ligands; D008081:Liposomes / Q000138:chemical synthesis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D018613:Microscopy, Confocal; D011956:Receptors, Cell Surface / Q000378:metabolism*
D037181:Lectins, C-Type; D008024:Ligands; D008081:Liposomes; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface