[Comparison between two anti-motion sickness drugs].
Objective. To test the validity of an animal model in selecting anti-motion sickness drugs, and compare the effects of two drugs. Method. Anti-motion sickness effects of two drugs (Cyclizine and Scopolamin-d-amphetamin compound) were observed in rats with motion sickness (MS) induced by rotatory stimulation and the amount of Kaolin ate by rats was taken as an evaluation criterion. Result. The consumption of Kaolin by the rats decreased significantly after administration of both drugs, and the effect of Scopolamin-d-amphetamin compound was better than those of Cyclizine under the same condition. Conclusion. It suggests that the rat model of motion sickness is practical and useful in studying anti-motion sickness drugs.
Wang
J
J
Institute of Space Medico-Engineering, Beijing, China.
Qian
J K
JK
Wang
B Z
BZ
Gao
J Y
JY
Shi
H Z
HZ
D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D003501:Cyclizine / Q000627:therapeutic use*; D003913:Dextroamphetamine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007616:Kaolin; D009041:Motion Sickness / Q000188:drug therapy* / Q000517:prevention & control; D010842:Pica / Q000188:drug therapy / Q000517:prevention & control; D051381:Rats; D012601:Scopolamine / Q000627:therapeutic use*
D000932:Antiemetics; D000697:Central Nervous System Stimulants; D004338:Drug Combinations; D007616:Kaolin; D012601:Scopolamine; D003501:Cyclizine; D003913:Dextroamphetamine