title: Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents.
abstract: The synthesis and evaluation of activity of some nitric acid esters of substituted morpholines are presented. All compounds inhibit lipid peroxidation and reduce cholesterol (20-63%) and triglyceride (37-85%) plasma levels. The more potent NO donors 14 and 17 specifically reduce low-density lipoprotein (LDL). These data indicate that proper structural modifications to the hypolipidemic and antioxidant morpholines enabling NO production, besides preserving or enhancing the above activities, offer a remarkable reduction of LDL, considered advantageous for antiatheromatic agents.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54 124, Greece.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Chrysselis
authors.forename: Eleni A
authors.initials: EA
authors.lastname: Rekka
authors.forename: Ioanna C
authors.initials: IC
authors.lastname: Siskou
authors.forename: Panos N
authors.initials: PN
authors.lastname: Kourounakis
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000097:blood; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009566:Nitrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D009025:Morpholines; D009566:Nitrates; D020030:Nitric Oxide Donors; D014280:Triglycerides; D002784:Cholesterol