title: Proton MR spectroscopy of Wernicke encephalopathy.
abstract: Two patients with acute thiamine deficiency were examined with thalamic single-voxel proton MR spectroscopy. T2-weighted images exhibited increased signal intensity. N-acetylaspartate (NAA)/creatine (Cr) ratios were low without detectable lactate. Owing to substantially decreased choline (Cho) T2, the Cho/Cr ratio was not decreased. After thiamine therapy, the NAA/Cr ratio increased, paralleling clinical improvement and reduction in the areas of signal-intensity changes.
authors.affiliation: Department of Clinical Pathophysiology, Radiodiagnostica I, Università di Firenze, Firenze, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Mascalchi
authors.forename: Giacomo
authors.initials: G
authors.lastname: Belli
authors.forename: Laura
authors.initials: L
authors.lastname: Guerrini
authors.forename: Marco
authors.initials: M
authors.lastname: Nistri
authors.forename: Ines
authors.initials: I
authors.lastname: Del Seppia
authors.forename: Natale
authors.initials: N
authors.lastname: Villari
mesh_terms: D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011522:Protons; D013832:Thiamine Deficiency / Q000150:complications / Q000175:diagnosis; D014899:Wernicke Encephalopathy / Q000175:diagnosis* / Q000209:etiology
chemical_list: D011522:Protons