title: B-Cell lymphoproliferative disorder not associated with Epstein-Barr Virus in a child with relapsed acute lymphoblastic leukemia.
abstract: Lymphoproliferative disorder (LPD) is described in only a few children receiving chemotherapy for cancer. In all of them, an association between LPD and EBV (Epstein-Barr Virus) was found. We report on a patient who developed LPD not associated with EBV while receiving chemotherapy for relapsed acute lymphoblastic leukemia (ALL). Despite discontinuation of chemotherapy, administration of intravenous immunoglobulins and surgery the patient died. Growing experience with this disorder may allow better treatment options in the future and will show whether LPD not associated with EBV requires different therapeutic strategies.
authors.affiliation: Department of Pediatrics, University of Würzburg, Germany. thomas_lehrnbecher@yahoo.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Lehrnbecher
authors.forename: Andreas
authors.initials: A
authors.lastname: Trusen
authors.forename: Frank
authors.initials: F
authors.lastname: Deinlein
authors.forename: Burkhard
authors.initials: B
authors.lastname: Höcht
authors.forename: Alexander
authors.initials: A
authors.lastname: Marx
authors.forename: Joachim
authors.initials: J
authors.lastname: Kühl
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes; D002675:Child, Preschool; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000601:surgery; D014412:Tumor Virus Infections / Q000209:etiology*