A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction.
The aim of this study was to examine the effect of Ginkgo biloba on antidepressant-induced sexual dysfunction. The Ginkgo biloba (n=19) and the placebo groups (n=18) were divided; each to be administered with Ginkgo biloba and placebo respectively for 2 months by means of a randomized placebo-controlled, double-blind study. The results of this 2 month trial were: (1) there was no statistical significant difference from the placebo at weeks 2, 4 and 8 after medication; (2) in comparison with baseline, both the Ginkgo biloba group and the placebo group showed improvement in some part of the sexual function, which is suggestive of the importance of the placebo effect in assessing sexual function. This study did not replicate a prior positive finding supporting the use of Ginkgo biloba for antidepressant, especially SSRI, induced sexual dysfunction.
Kang
Byung-Jo
BJ
Department of Psychiatry, School of Medicine, Kyungpook National University, Taegu, South Korea. kuhpkbj@knu.ac.kr
Lee
Seung-Jae
SJ
Kim
Moon-Doo
MD
Cho
Man-Je
MJ
D000928:Antidepressive Agents / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000188:drug therapy*; D005260:Female; D020441:Ginkgo biloba; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome; D000096983:Ginkgo Extract
D000928:Antidepressive Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract