title: Phenolic antibacterials from Piper betle in the prevention of halitosis.
abstract: Piper betle L. (Piperaceae) leaves which are traditionally used in India and China in the prevention of oral malodor was examined by bioassay-guided fractionation to yield allylpyrocatechol (APC) as the major active principle which showed promising activity against obligate oral anaerobes responsible for halitosis. The biological studies with APC indicated that the potential to reduce methylmercaptan and hydrogen sulfide was mainly due to the anti-microbial activity as established using dynamic in vitro models.
authors.affiliation: The Procter & Gamble Company, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. ramji.n@pg.com
authors.forename: Niranjan
authors.initials: N
authors.lastname: Ramji
authors.forename: Nivedita
authors.initials: N
authors.lastname: Ramji
authors.forename: Ritu
authors.initials: R
authors.lastname: Iyer
authors.forename: S
authors.initials: S
authors.lastname: Chandrasekaran
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D016967:Fusobacterium nucleatum / Q000187:drug effects; D006209:Halitosis / Q000517:prevention & control*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D010462:Peptostreptococcus / Q000187:drug effects; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D031721:Piper betle; D026321:Piperaceae; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D016966:Porphyromonas gingivalis / Q000187:drug effects; D012463:Saliva / Q000382:microbiology; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D010636:Phenols; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; C005231:methylmercaptan; D006862:Hydrogen Sulfide