title: Early brain atrophy in persistent hyperinsulinemic hypoglycemia of infancy.
abstract: We present two siblings with persistent hyperinsulinemic hypoglycemia of infancy, accelerated intrauterine growth and early neonatal brain atrophy. Fetal plasma glucose and insulin levels in the second sibling revealed normoglycemia despite hyperinsulinemia. The absence of intrauterine hypoglycemia suggests that the brain damage is not secondary to hypoglycemia and other etiologies must be considered.
authors.affiliation: Department of Obstetrics and Gynecology, The Pediatric Endocrine Unit and Endocrine Laboratory, HaEmek Medical Center, Afula, Israel.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Nachum
authors.forename: Izhar
authors.initials: I
authors.lastname: Ben-Shlomo
authors.forename: Yardena
authors.initials: Y
authors.lastname: Rakover
authors.forename: Ehud
authors.initials: E
authors.lastname: Weiner
authors.forename: Eliezer
authors.initials: E
authors.lastname: Shalev
mesh_terms: D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000235:genetics / Q000473:pathology*; D007003:Hypoglycemia / Q000209:etiology / Q000235:genetics / Q000473:pathology; D007231:Infant, Newborn; D008297:Male; D014057:Tomography, X-Ray Computed