The relationship between myelodysplastic syndromes and autoimmune disorders.
OBJECTIVE
To explore the relationship between the myelodysplastic syndromes (MDS) and autoimmune disorders (AID).


METHODS
The clinical data of 117 MDS patients were reviewed.


RESULTS
Nineteen (16.2%) of 117 MDS patients had AIDs. The commonest AID associated with MDS was rheumatoid arthritis (31.6%) and ulcerative colitis (26.3%). Compared with that in MDS patients without autoimmune disorders, the leukemic transformation rate was not increased in the MDS/AID but the median survival time was shorter in MDS/AID patients.


CONCLUSIONS
MDS patients associated with autoimmune disorders may be an unfavorable factor for their prognosis.
Zhao
Shi
S
Department of Hematology, The Second Hospital of Wuhan, Wuhan 430014, China.
Mao
Hong
H
Wang
Hongxiang
H
Yu
Jie
J
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications*; D003093:Colitis, Ulcerative / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011237:Predictive Value of Tests