Immunomodulation of inherent behavior in C57Bl/6 and BALB/c mice with antibodies to glutamate.
Immunization of BALB/c mice with glutamate-BSA conjugate reduced anxiety and improved passive avoidance retention, while in C57Bl/6 mice immunization disturbed passive avoidance retention, but had no effect on anxiety. Interstrain differences in the shuttle box behavior were found between control animals.
Trekova
N A
NA
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow.
Mikovskaya
O I
OI
Basharova
L A
LA
Vetrile
L A
LA
Evseev
V A
VA
D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D001362:Avoidance Learning; D001519:Behavior / Q000502:physiology*; D018698:Glutamic Acid / Q000276:immunology* / Q000378:metabolism; D007107:Immune System / Q000502:physiology*; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D000906:Antibodies; D018698:Glutamic Acid