title: Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism.
abstract: Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.
authors.affiliation: Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: A V
authors.initials: AV
authors.lastname: Krylatov
authors.forename: R V
authors.initials: RV
authors.lastname: Uzhachenko
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: N A
authors.initials: NA
authors.lastname: Bernatskaya
authors.forename: A
authors.initials: A
authors.lastname: Makriyannis
authors.forename: R
authors.initials: R
authors.lastname: Mechoulam
authors.forename: R G
authors.initials: RG
authors.lastname: Pertwee
authors.forename: O M
authors.initials: OM
authors.lastname: Sal'nikova
authors.forename: J B
authors.initials: JB
authors.lastname: Stefano
authors.forename: YuB
authors.initials: Y
authors.lastname: Lishmanov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001095:Arachidonic Acids / Q000737:chemistry / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology; D002186:Cannabinoids / Q000737:chemistry / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D063388:Endocannabinoids; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D015221:Potassium Channels / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism
chemical_list: D000889:Anti-Arrhythmia Agents; D001095:Arachidonic Acids; D002121:Calcium Channel Blockers; D002186:Cannabinoids; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D053284:Polyunsaturated Alkamides; D015221:Potassium Channels; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D000242:Cyclic AMP; D005905:Glyburide; C078814:anandamide; D019331:NG-Nitroarginine Methyl Ester