title: Effect of diabetes on peritoneal function assessed by personal dialysis capacity test in patients undergoing CAPD.
abstract: BACKGROUND
  We evaluated differences in individual peritoneal membrane transport function and nutritional status in patients with diabetes mellitus (DM) and nondiabetic (non-DM) patients on continuous ambulatory peritoneal dialysis (CAPD).
  
  
  METHODS
  We used a newly developed peritoneal function test, personal dialysis capacity, in 88 patients (44 DM and 44 non-DM) on CAPD for 1 to 210 months. Sex, age, past history of peritonitis, and duration of CAPD were matched in DM and non-DM patients.
  
  
  RESULTS
  Serum albumin (mean +/- SEM) was lower in DM compared with non-DM patients: 3.0 +/- 0.1 g/dL (30 +/- 1 g/L) versus 3.5 +/- 0.1 g/dL (35 +/- 1 g/L), P < 0.001. Peritoneal area and dialysis protein loss were greater in DM versus non-DM patients. In multiple linear regression analysis, the only independent predictor of serum albumin in patients with DM was dialysis protein loss. In contrast, age, past history of peritonitis, duration of CAPD, caloric intake, protein nitrogen appearance and protein catabolic rate, and residual renal function did not correlate with serum albumin in DM patients. In non-DM patients, age, duration of CAPD, and past history of peritonitis, but not dialysis protein loss, were independent predictors of serum albumin. There was a significant correlation in DM patients, but not in non-DM CAPD patients, between dialysis protein loss and urinary excretion of protein (r = 0.866, P = 0.0005).
  
  
  CONCLUSIONS
  In this multicenter study, peritoneal membrane transport and peritoneal protein permeability were significantly higher in DM than in non-DM patients. Hypoproteinemia in DM patients is attributable to the high permeability of the peritoneal membrane undergoing CAPD.
authors.affiliation: Department of Nephrology, Saitama Medical School, and PDC Study Group in Japan, Saitama, Japan.
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Nakamoto
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Imai
authors.forename: Hideki
authors.initials: H
authors.lastname: Kawanishi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakamoto
authors.forename: Jun
authors.initials: J
authors.lastname: Minakuchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kumon
authors.forename: Syuichi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Shiohira
authors.forename: Takeo
authors.initials: T
authors.lastname: Ishii
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kawahara
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuzaki
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000367:Age Factors; D000419:Albuminuria / Q000097:blood / Q000503:physiopathology; D000704:Analysis of Variance; D001692:Biological Transport / Q000502:physiology; D001798:Blood Proteins / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D015314:Dialysis Solutions / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods / Q000706:statistics & numerical data; D010537:Peritoneum / Q000503:physiopathology*; D010538:Peritonitis / Q000209:etiology / Q000503:physiopathology; D011507:Proteinuria / Q000097:blood / Q000503:physiopathology; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism; D012737:Sex Factors
chemical_list: D001798:Blood Proteins; D015314:Dialysis Solutions; D012709:Serum Albumin