title: Mechanisms of enzymatic CbondO bond cleavages in deoxyhexose biosynthesis.
abstract: In the past few years, significant progress has been made in our understanding of the biosynthesis of deoxyhexoses. Mechanistic studies have revealed how enzymes can cleave CbondO bonds of a hexose substrate to make unusual sugars. The increasing amount of knowledge about the biosynthesis of deoxysugars may allow the assembly of a repertoire of novel sugar structures through recruitment and collaborative action of genes from a variety of biosynthetic pathways to create diverse secondary metabolites in our search for novel antibiotic/antitumour agents.
authors.affiliation: Division of Medicinal Chemistry, College of Pharmacy, Department of Chemistry and Biochemistry, University of Texas, Austin 78712, USA.
authors.forename: Xuemei
authors.initials: X
authors.lastname: He
authors.forename: Hung-wen
authors.initials: HW
authors.lastname: Liu
mesh_terms: D003837:Deoxy Sugars / Q000096:biosynthesis* / Q000737:chemistry*; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D006601:Hexoses / Q000096:biosynthesis* / Q000737:chemistry*; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003837:Deoxy Sugars; D004798:Enzymes; D006601:Hexoses; D010100:Oxygen