title: Viral evasion of natural killer cells.
abstract: Viruses have evolved mechanisms to avoid the host immune system, including means of escaping detection by both the innate and adaptive immune responses. Natural killer (NK) cells are a central component of the innate immune system and are crucial in defense against certain viruses. To attain a state of chronic infection, some successful viruses have developed specific mechanisms to evade detection by and activation of NK cells. These NK cell-specific evasion mechanisms fall into distinct mechanistic categories used in numerous virus families.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge MA, USA.
authors.forename: Jordan S
authors.initials: JS
authors.lastname: Orange
authors.forename: Marlys S
authors.initials: MS
authors.lastname: Fassett
authors.forename: Louise A
authors.initials: LA
authors.lastname: Koopman
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Boyson
authors.forename: Jack L
authors.initials: JL
authors.lastname: Strominger
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000235:genetics / Q000502:physiology; D003602:Cytotoxicity, Immunologic; D015536:Down-Regulation; D015967:Gene Expression Regulation, Viral; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology; D051379:Mice; D018448:Models, Immunological; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000235:genetics / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D018925:Chemokines; D016207:Cytokines; D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic