Replicating past lesions in DNA.
Replication of damaged DNA is essential in all organisms and is potentially achieved by several mechanisms. How Escherichia coli employs these different mechanisms to effect efficient, accurate replication of a damaged template is revealed in this issue of Molecular Cell.
McGlynn
Peter
P
Institute of Genetics, University of Nottingham, Queen's Medical Centre, NG7 2UH, Nottingham, United Kingdom.
Lloyd
Robert G
RG
D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D016296:Mutagenesis
D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase