Inaudible functional MRI using a truly mute gradient echo sequence.
We performed functional MRI experiments using a mute version of a gradient echo sequence on adult volunteers using either a simple visual stimulus (flicker goggles: 4 subjects) or an auditory stimulus (music: 4 subjects). Because the mute sequence delivers fewer images per unit time than a fast echo planar imaging (EPI) sequence, we explored our data using a parametric ANOVA test and a non-parametric Wilcoxon-Mann-Whitney test in addition to performing a cross-correlation analysis. All three methods were in close agreement regarding the location of the BOLD contrast signal change. We demonstrated that, using appropriate statistical analysis, functional MRI using an MR sequence that is acoustically inaudible to the subject is feasible. Furthermore compared with the "silent" event-related procedures involving an EPI protocol, our mGE protocol compares favourably with respect to experiment time and the BOLD signal.
Marcar
V L
VL
University of Zurich, Department of Psychology, Neuropsychology, Treichlerstrasse 10, 8032 Zurich, Switzerland. v.marcar@psychologie.unizh.ch
Girard
F
F
Rinkel
Y
Y
Schneider
J F
JF
Martin
E
E
D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010775:Photic Stimulation