title: Expression of cyclin D1 in small cell lymphoma and its clinical implications.
abstract: OBJECTIVE: To observe the expression of cyclin D1 and explore its clinical significance in small cell lymphoma. METHODS: Immunohistochemical method was used to detect the expression of CD20, CD45RO and cyclin D1 in 31 formalin- fixed and paraffin-embedded tissue samples of human small cell lymphomas. RESULTS: Twenty-eight cases were categorized into B cell lymphoma and 3 into T cell lymphoma. Only 5 cases of B cell lymphoma had cyclin D1 expression (17.86%) that did not significantly differ between nodal and extranodal lymphomas (P>0.05), indicating the presence of mantle cell lymphoma. CONCLUSION: The overexpression of cyclin D1 is a highly characteristic and specific indicator that discriminates mantle cell lymphoma from other small cell lymphomas, and this protein may offer critial guidance for therapeutic protocol and prognostic estimation.
authors.affiliation: Department of Pathology, First Military Medical University, Guangzhou 510515, China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Zhou
authors.forename: Tong
authors.initials: T
authors.lastname: Zhao
authors.forename: Mei-Gang
authors.initials: MG
authors.lastname: Zhu
authors.forename: Zhen-Xi
authors.initials: ZX
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Yang