Influence of various phosphopeptides of caseins on iron absorption.
The influence of the origin and kind of caseinophosphopeptide (CPP) on iron absorption was assessed by comparing a commercially available CPP mixture (CPPs) and derived chromatographic fractions with the purified, chemically phosphopeptide of beta-casein [beta-CN(1-25)] using a perfused rat duodenal loop system; gluconate iron was used as control. Only iron complexed to beta-CN(1-25) displayed a better bioavailability than gluconate iron. The results obtained with various chromatographic fractions indicated that phosphopeptides of different origins (alpha(s)- versus beta-caseins) display specific effects. These findings contribute to the explanation of the discrepancy about the role of caseinophosphopeptides on mineral bioavailability in vivo.
Bouhallab
Saíd
S
Laboratoire de Recherches de Technologie Laitière, INRA, 65 rue de Saint Brieuc, F-35042 Rennes Cedex, France.
Cinga
Vladas
V
Aít-Oukhatar
Nabil
N
Bureau
François
F
Neuville
Dominique
D
Arhan
Pierre
P
Maubois
Jean-Louis
JL
Bouglé
Dominique
D
D000818:Animals; D001682:Biological Availability; D002364:Caseins / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D005942:Gluconates / Q000493:pharmacokinetics; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000493:pharmacokinetics*; D013058:Mass Spectrometry; D010446:Peptide Fragments / Q000493:pharmacokinetics; D010748:Phosphopeptides / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002364:Caseins; D005942:Gluconates; D010446:Peptide Fragments; D010748:Phosphopeptides; C412562:caseinophosphopeptide 1-25; D007501:Iron