Effects of black radish root (Raphanus sativus L. var niger) on the colon mucosa in rats fed a fat rich diet.
The effect of black radish root (Raphanus sativus L. var niger) was studied on the structure and redox state of the colon mucosa in fat-rich diet fed rats. The epithelial lining disrupted, the number of enterocytes and the goblet cells reduced and inflammatory cells were observed in rats fed with a fat-rich diet. After treatment with granules from black radish root all of the histopathological changes and parameters of the redox state caused by the fat-rich diet were improved. The structure of the epithelial cells was similar to the controls, the number of goblet cells increased and no inflammation was observed.
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2nd Department of Surgery, Semmelweis University, H-1125 Budapest, Kútvölgyi u. 4, Hungary. speter@kut.sote.hu
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D000818:Animals; D003106:Colon / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D004041:Dietary Fats; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D031224:Raphanus; D051381:Rats; D017208:Rats, Wistar
D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010936:Plant Extracts