The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women.
The recently discovered hormone leptin is primarily secreted by adipose tissue and serves as an internal signal indicating the size of body fat stores. The aim of the present study was to investigate the impact of the dietary fatty acid composition on serum leptin concentrations. Therefore, serum leptin levels were measured by RIA in healthy nonobese men (n = 30) and women (n = 25). First, all participants received a baseline high-fat diet, rich in saturated fat, for 2 wk and were then randomly assigned to one of three high-fat dietary treatments, which contained refined olive oil (rich in monounsaturated fatty acids, n = 19), rapeseed oil [rich in monounsaturated fatty acids and alpha-linolenic acid (18:3n-3), n = 17], or sunflower oil (rich in n-6-polyunsaturated fatty acids, n = 19) as the principal source of fat for 4 wk. On the rapeseed oil diet, serum leptin concentrations increased slightly in men [+0.25 ng/ml, T(9) = -2.778, P = 0.021], but decreased distinctly in women [-4.70 ng/ml, T(6) = 5.083, P = 0.002]. Both the olive oil and the sunflower oil diet did not affect serum leptin concentrations. Thus, it is proposed that serum leptin levels were affected by the high amount of alpha-linolenic acid in rapeseed oil. However, questions remain as to why this diet differently affected serum leptin in men and women.
Kratz
Mario
M
Institute of Arteriosclerosis Research, University of Muenster, Domagkstrasse 3, 48149 Muenster, Germany. mkratz@uni-muenster.de
von Eckardstein
Arnold
A
Fobker
Manfred
M
Buyken
Anette
A
Posny
Nicole
N
Schulte
Helmut
H
Assmann
Gerd
G
Wahrburg
Ursel
U
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000008:administration & dosage; D005229:Fatty Acids, Monounsaturated; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D000074262:Rapeseed Oil; D012727:Sex Characteristics; D000074242:Sunflower Oil; D017962:alpha-Linolenic Acid / Q000008:administration & dosage
D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D006442:Glycated Hemoglobin; D007328:Insulin; D020738:Leptin; D000069463:Olive Oil; D010938:Plant Oils; D000074262:Rapeseed Oil; D000074242:Sunflower Oil; D017962:alpha-Linolenic Acid