title: [Day-night variability of the prehospital phase of acute myocardial infarct].
abstract: While a circadian rhythm in the onset of acute myocardial infarction (AMI) is well established, little is known about the variability of prehospital delay and decision processes. Seven hundred and thirty-nine consecutive AMI patients (median age 65.3 years; 30.2% women) with a median decision time of 60 min and a total prehospital delay of 180 min were studied. In 30.9% of patients onset of AMI symptoms was at night (10.00 p.m.-06.00 a.m.). At night patient decision time was significantly longer than during daytime (120 vs 45 min, difference 75 min; p < 0.001), total prehospital delay was prolonged accordingly (240 vs 170 min, difference 70 min; p < 0.001). The relative risk (RR; 95% confidence interval, CI) for a late decision (> 1 h) to seek medical care at night was significantly increased in females (RR 1.96; CI 1.07-3.61, p = 0.028), non-smokers (RR 2.49; CI 1.42-4.39, p = 0.001) and patients with radiation of anginal pain (RR 2.34; CI 1.32-4.15; p = 0.003). Of all patients with a late decision to seek medical care at night, 95.6% belonged to one of these groups. These variables were not significant for early or late decisions during daytime. Decision processes of AMI patients may be different during daytime and at night. In conclusion, in AMI patients, decision time to seek medical help is prolonged at night. Simple clinical variables (female sex, non-smokers, radiation of anginal pain) identify patients at high risk for a late decision at night. This information should be included into public and individualized education campaigns.
authors.affiliation: Medizinische Abteilung Krankenhaus Itzehoe Akademisches Lehrkrankenhaus, Universitäten Kiel und Lübeck Robert-Koch-Str. 2 25524 Itzehoe, Germany. m.kentsch@kh-itzehoe.de
authors.forename: M
authors.initials: M
authors.lastname: Kentsch
authors.forename: U
authors.initials: U
authors.lastname: Rodemerk
authors.forename: T H
authors.initials: TH
authors.lastname: Ittel
authors.forename: G
authors.initials: G
authors.lastname: Müller-Esch
authors.forename: R
authors.initials: R
authors.lastname: Mitusch
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002940:Circadian Rhythm; D003937:Diagnosis, Differential; D004632:Emergency Medical Services / Q000706:statistics & numerical data*; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D012737:Sex Factors; D013647:Task Performance and Analysis; D013997:Time Factors