title: Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-bases.
abstract: Nicotinic acid derived Schiff bases and their transition metal [cobalt(II), nickel(II) and zinc(II)] complexes have been prepared and characterized by physical, spectral and analytical data. The Schiff bases act as deprotonated tridentate ligands for the complexation of the above mentioned metal ions. These complexes, possessing the general formula [M(L)2] [where M = Co(II), Ni(II) and Zn(II) and L = HL1-HL4] showed an octahedral geometry of the metal ions. For determining the effect of metal ions upon chelation, the Schiff bases and their complexes have been screened for antibacterial activity against several pathogenic strains of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The new metal derivatives reported here were more bactericidal against one or more bacterial species as compared to the uncomplexed Schiff bases.
authors.affiliation: Department of Chemistry, Islamia University, Bahawalpur, Pakistan.
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Abdul
authors.initials: A
authors.lastname: Rau
authors.forename: Sobia
authors.initials: S
authors.lastname: Noreen
authors.forename: Andrea
authors.initials: A
authors.lastname: Scozzafava
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009525:Niacin / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D015032:Zinc / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D012545:Schiff Bases; D009525:Niacin; D003035:Cobalt; D009532:Nickel; D015032:Zinc