The Baylis-Hillman condensation of alpha,beta-conjugate cycloketones with aldehydes using diethylaluminum iodide alone as the promoter.
The Baylis-Hillman condensation of three types of alpha,beta-conjugate cycloketones with aldehydes was successfully performed by using diethylaluminum iodide as the Lewis acid promoter alone without the direct use of a Lewis base. The reaction proceeded to completion at 0 degree C in CH2Cl2 within 24 h to give modest to good yields (53-72%).
Pei
Wei
W
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA.
Wei
Han-Xun
HX
Li
Guigen
G
D000447:Aldehydes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D006844:Hydrocarbons, Cyclic / Q000737:chemistry; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry
D000447:Aldehydes; D006844:Hydrocarbons, Cyclic; D007202:Indicators and Reagents; D007659:Ketones; D009942:Organometallic Compounds; C476279:diethylaluminum iodide