Experimental and clinical rationale for use of MMF in nontransplant progressive nephropathies.
The incidence of progressive nephropathies and, consequently, the population suffering from end-stage renal disease have increased steadily in recent years, posing an ever-growing cost, in both human and financial terms, to society. There is mounting evidence that, in both immune-mediated and nonimmune-mediated chronic nephropathies, renal inflammatory events are key to the propagation and perpetuation of renal injury. Mycophenolate mofetil (MMF) is an antilymphocyte agent recently introduced in clinical practice for the prevention of allograft rejection. The present review discusses clinical and experimental evidence that the anti-inflammatory action of MMF can be advantageously used to arrest immune- and nonimmune-mediated progressive injury of native kidneys as well.
Zatz
Roberto
R
Renal Division, Department of Clinical Medicine, University of São Paulo, Av. Dr. Arnaldo 455, 3-s/3342, São Paulo 01246-903, Brazil. rzatz@usp.br
Noronha
Irene Lourdes
IL
Fujihara
Clarice Kazue
CK
D018450:Disease Progression; D004359:Drug Therapy, Combination; D006801:Humans; D007154:Immune System Diseases / Q000150:complications; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid