[Origin of cortical interneurons: basic concepts and clinical implications].
Introduction and development. GABAergic interneurons play a prominent role in the function of the cerebral cortex, since they allow the synchronization of pyramidal neurons and greatly influence their differentiation and maturation during development. Until recently it has been thought that cortical interneurons and pyramidal neurons originate from progenitor cells located in the dorsal region of the telencephalon, the pallium. Recent studies, however, have demonstrated that a large number of cortical GABAergic neurons arise from progenitors located in the subpallium the region of the telencephalon that gives rise to the basal ganglia, and that they arise in the cerebral cortex after a long tangential migration. Aims. In this review I have summarized our current knowledge of the factors that control the specification of cortical interneurons, as well as the mechanisms that direct their migration to the cortex.
Marín
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Division of Neurobiología del Desarrollo, Instituto de Neurociencias, CSIC, Universidad Miguel Hernández, San Juan de Alicate, Alicate, España. o.marin@umh.es
D000818:Animals; D019070:Cell Lineage; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology*; D006801:Humans; D007395:Interneurons / Q000737:chemistry / Q000166:cytology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D009422:Nervous System Diseases / Q000196:embryology / Q000473:pathology; D013687:Telencephalon / Q000166:cytology; D014157:Transcription Factors / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D005680:gamma-Aminobutyric Acid