title: Protein-cleaving catalyst selective for protein substrate.
abstract: A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. [reaction: see text]
authors.affiliation: School of Chemistry and Center for Molecular Catalysis, Seoul National University, Seoul 151-747, Korea.
authors.forename: Joong Won
authors.initials: JW
authors.lastname: Jeon
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Son
authors.forename: Chang Eun
authors.initials: CE
authors.lastname: Yoo
authors.forename: In Seok
authors.initials: IS
authors.lastname: Hong
authors.forename: Jung Bae
authors.initials: JB
authors.lastname: Song
authors.forename: Junghun
authors.initials: J
authors.lastname: Suh
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D007202:Indicators and Reagents; D007700:Kinetics; D020135:Peptide Nucleic Acids / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013379:Substrate Specificity
chemical_list: D007202:Indicators and Reagents; D020135:Peptide Nucleic Acids; D011506:Proteins