title: Evidence of exercise-induced cardiac dysfunction and elevated cTnT in separate cohorts competing in an ultra-endurance mountain marathon race.
abstract: Cardiac damage has recently been implicated in the aetiology of "exercise induced cardiac dysfunction". The humoral markers of cardiac damage that have been utilised to date are not sufficiently cardio-specific to investigate this hypothesis. The aim of the present study was to examine cardiac function following prolonged exercise, and investigate the contention of cardiac damage utilising a new highly cardio-specific marker. Thirty-seven competitors in the 2-day Lowe Alpine Mountain Marathon 2000 volunteered for the study. Competitors were sub-divided into 2 groups. Group 1 (n = 11) were examined using echocardiography pre and post the event, examining left ventricular diastolic and systolic function. Group 2 (n = 26) had venous blood samples drawn prior to the event and immediately following day-1 and day-2. Blood samples were analysed for total creatine kinase activity (CK), creatine kinase isoenzyme MB(mass) (CK-MB(mass)), and cardiac troponin T. Echocardiographic results indicated left ventricular diastolic and systolic dysfunction following cessation of exercise. CK and CK-MB(mass) were both elevated following day-1, and immediately following race completion. Cardiac troponin T levels were below the 99th percentile (0.01 microg/L) in all subjects prior to the event, following day-1 cTnT was elevated above 0.01 microg/L in 13 subjects, but returned to below 0.01 microg/L following race completion on day-2. However, no individual data reached clinical cut-off levels for acute myocardial infarction (AMI) (0.1 microg/L). Two days arduous exercise over mountainous terrain resulted in cardiac dysfunction, and significant skeletal muscular degradation. The elevation of cTnT above the 99th percentile in the present study is suggestive of minimal myocardial damage. The clinical significance of and exact mechanism responsible for such damage remains to be elucidated.
authors.affiliation: British Olympic Medical Centre, Northwick Park Hospital, Harrow, Middlesex, UK. robert.shave@boa.org.uk
authors.forename: R E
authors.initials: RE
authors.lastname: Shave
authors.forename: E
authors.initials: E
authors.lastname: Dawson
authors.forename: G
authors.initials: G
authors.lastname: Whyte
authors.forename: K
authors.initials: K
authors.lastname: George
authors.forename: D
authors.initials: D
authors.lastname: Ball
authors.forename: D C
authors.initials: DC
authors.lastname: Gaze
authors.forename: P O
authors.initials: PO
authors.lastname: Collinson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015331:Cohort Studies; D015150:Echocardiography, Doppler; D006331:Heart Diseases / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D012420:Running / Q000502:physiology*; D020107:Troponin T / Q000032:analysis*
chemical_list: D020107:Troponin T