The neurotrophin receptor p75NTR as a positive modulator of myelination.
Schwann cells in developing and regenerating peripheral nerves express elevated levels of the neurotrophin receptor p75NTR. Neurotrophins are key mediators of peripheral nervous system myelination. Our results show that myelin formation is inhibited in the absence of functional p75NTR and enhanced by blocking TrkC activity. Moreover, the enhancement of myelin formation by endogenous brain-derived neurotrophic factor is mediated by the p75NTR receptor, whereas TrkC receptors are responsible for neurotrophin-3 inhibition. Thus p75NTR and TrkC receptors have opposite effects on myelination.
Cosgaya
Jose M
JM
Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Fairchild Building, Stanford, CA 94305, USA.
Chan
Jonah R
JR
Shooter
Eric M
EM
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001369:Axons / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology / Q000502:physiology; D018920:Coculture Techniques; D005727:Ganglia, Spinal / Q000166:cytology; D007150:Immunohistochemistry; D051379:Mice; D008959:Models, Neurological; D018993:Myelin P0 Protein / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology*; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D020933:Neurotrophin 3 / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020800:Receptor, Nerve Growth Factor; D020813:Receptor, trkB / Q000378:metabolism; D020812:Receptor, trkC / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000276:immunology / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012583:Schwann Cells / Q000502:physiology*; D012584:Sciatic Nerve / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction
D000906:Antibodies; D019208:Brain-Derived Neurotrophic Factor; D018993:Myelin P0 Protein; D018992:Myelin-Associated Glycoprotein; D020933:Neurotrophin 3; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D020813:Receptor, trkB; D020812:Receptor, trkC