Quantitative structure-activity relationships study of a series of imidazole derivatives as potential new antifungal drugs.
The Quantitative Structure-Activity Relationships (QSAR) has been developed to relate antifungal activity against Candida albicans and Rhodotorula glutinis of new imidazole derivatives with their physico-chemical and structural properties. For 265 imidazole derivatives the most significant statistically equations has been obtained with correlation coefficients R=0.800 and R=0.820 in case of activity against Ca. and Rh.g., respectively. The overall antifungal activity has been described by means of size and bulkiness related parameters as well as polar and lipophilic interactions. The significance of lipophilicity in terms of n-octanol/water partition coefficient, ClogP, on antifungal potency against both fungi has been investigated. QSAR equations for different classes of antifungal activity have been obtained. With a very high probability level (92% and 96%) the weak or very weak antifungal potency against C.a. can be determined and thus the number of required experiments can be reduced.
Wiktorowicz
Włodzimierz
W
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Poland.
Markuszewsk-
Michal
M
Krysiński
Jerzy
J
Kaliszan
Roman
R
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000706:statistics & numerical data; D021281:Quantitative Structure-Activity Relationship
D000935:Antifungal Agents; D007093:Imidazoles