Pancreatic T-cell lymphoma with high level of soluble interleukin-2 receptor.
An 82-year-old man was admitted to hospital with symptoms of abdominal fullness and loss of appetite. Abdominal computed tomography (CT) scan and ultrasonography showed enlargement of the whole pancreas with para-aortic lymphadenopathy. Endoscopic retrograde pancreatography (ERP) showed diffuse narrowing of the main pancreatic duct (MPD), and brushing cytology from the MPD was non-neoplastic. Differential diagnosis between lymphoma and other exocrine and endocrine pancreatic malignancies was needed, and the level of serum soluble interleukin-2 receptor (17 751 U/ml) was revealed to be significantly high, which was strongly suggestive of pancreatic lymphoma. Chemotherapy was refused by the patient's family and the patient succumbed after 2 months of conservative follow-up. Autopsy revealed diffuse, mixed cell-type, non-Hodgkin's lymphoma of T-cell subtype.
Matsubayashi
Hiroyuki
H
Department of Gastroenterology, Tachikawa General Hospital, 3-2-11 Kanda-cho, Nagaoka 940-8621, Japan.
Takagaki
Shinichi
S
Otsubo
Takao
T
Iiri
Takao
T
Kobayashi
Yuka
Y
Yokota
Takashi
T
Shichijo
Kimitoshi
K
Iwafuchi
Mitsuya
M
Kijima
Hiroshi
H
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000097:blood / Q000175:diagnosis*; D008297:Male; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D015375:Receptors, Interleukin-2 / Q000097:blood*
D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2