Ruthenium-catalyzed s-propargylation of thiols enables the rapid synthesis of propargylic sulfides.
A new and highly efficient catalytic system based on CpRuClL2 is proposed for the S-propargylation of thiols by propargylic carbonates under neutral conditions, in which specific requirements inherent to the different reactivities of aliphatic and aromatic thiols are achieved by tuning both the nature of the ancillary ligand L and the experimental conditions.
Kondo
Teruyuki
T
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Kanda
Yusuke
Y
Baba
Atsushi
A
Fukuda
Kenji
K
Nakamura
Ayako
A
Wada
Kenji
K
Morisaki
Yasuhiro
Y
Mitsudo
Take-Aki
TA
D000480:Alkynes / Q000138:chemical synthesis*; D002219:Carbamates / Q000737:chemistry; D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013440:Sulfides / Q000138:chemical synthesis*
D000480:Alkynes; D002219:Carbamates; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D013440:Sulfides; D012428:Ruthenium