title: Fibrin glue-reinforced closure of postlaryngectomy pharyngocutaneous fistula.
abstract: Pharyngocutaneous fistulization is a dreaded and devastating complication of laryngectomy. Although the specific risk factors are controversial, a history of prior radiation therapy has generally been accepted to be a major risk factor for developing this complication. We present a case of a postlaryngectomy pharyngocutaneous fistula developing in a previously irradiated patient that was successfully managed by incorporating fibrin glue into the surgical closure. We also discuss the underlying theoretical basis for this approach by reviewing the relevant literature.
authors.affiliation: Division of Head and Neck Surgery, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA.
authors.forename: Sam
authors.initials: S
authors.lastname: Wiseman
authors.forename: Wesley
authors.initials: W
authors.lastname: Hicks
authors.forename: Thom
authors.initials: T
authors.lastname: Loree
authors.forename: Mazin
authors.initials: M
authors.lastname: Al-kasspooles
authors.forename: Nestor
authors.initials: N
authors.lastname: Rigual
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D017577:Cutaneous Fistula / Q000209:etiology / Q000601:surgery*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy; D007825:Laryngectomy / Q000009:adverse effects*; D008297:Male; D010608:Pharyngeal Diseases / Q000209:etiology / Q000601:surgery*; D012307:Risk Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives