mRNA at synapses, synaptic plasticity, and memory consolidation.
Miller et al. (this issue of Neuron) report that deletion of the 3'UTR of alpha-CaMKII mRNA prevents dendritic delivery of the mRNA in transgenic mice and thus local synthesis of alpha-CaMKII protein in dendrites. 3'UTR mutant mice exhibit decreases in alpha-CaMKII protein in postsynaptic densities, and deficits in late phase LTP and in memory consolidation.
Steward
Oswald
O
Reeve-Irvine Research Center, Department of Anatomy and Neurobiology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA 92697, USA.
D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D003712:Dendrites / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000235:genetics*; D008568:Memory / Q000502:physiology*; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
D020413:3' Untranslated Regions; D012333:RNA, Messenger; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases