title: Prediction of apparent equilibrium solubility of indomethacin compounded with silica by 13C solid state NMR.
abstract: The apparent equilibrium solubility (AES) of indomethacin increased by co-grinding with silica. Change in the long- and short range disorder of indomethacin by co-grinding was examined by X-ray powder diffraction and 13C solid state NMR, respectively, to elucidate the increased AES. Since the increase in AES was particularly marked after complete disappearance of X-ray diffraction peaks, we attributed the enhanced AES primarily to the short range disorder on the molecular basis. This was confirmed by a high correlation between the standardized full width at half maximum (SFWHM) of the specific peaks observed by 13C solid state NMR and log (AES). The correlation enables the prediction of AES as well.
authors.affiliation: Product Development Laboratories, Sankyo Co. Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. watatm@shina.sankyo.co.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Susumu
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Wakiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Kusai
authors.forename: Mamoru
authors.initials: M
authors.lastname: Senna
mesh_terms: D002250:Carbon Radioisotopes; D002626:Chemistry, Pharmaceutical; D007213:Indomethacin / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011237:Predictive Value of Tests; D012822:Silicon Dioxide / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility
chemical_list: D002250:Carbon Radioisotopes; D012822:Silicon Dioxide; D007213:Indomethacin