title: The erythrocyte adhesiveness/aggregation test (EAAT). A new biomarker to reveal the presence of low grade subclinical smoldering inflammation in individuals with atherosclerotic risk factors.
abstract: BACKGROUND
  Multiple acute phase proteins and atherosclerotic risk factors increase the aggregability of erythrocytes.
  
  
  RESULTS
  We used a simple slide test and image analysis to determine the degree of erythrocyte adhesiveness/aggregation in the peripheral blood of 222 women and 221 men with no, one, two or more atherosclerotic risk factors. The degree of erythrocyte adhesiveness/aggregation correlated significantly with the concentration of commonly used variables of the acute phase response. We also showed that individuals with low erythrocyte adhesiveness/aggregation tend to be younger and to have fewer risk factors for atherosclerosis, including diabetes mellitus, hypertension, hyperlipidemia and smoking.
  
  
  CONCLUSIONS
  The association between increased erythrocyte adhesiveness/aggregation, higher concentrations of acute phase proteins, and increased atherosclerotic risk factors points to a possible clinical applicability of the erythrocyte adhesiveness/aggregation test (EAAT) to reveal the presence of both low-grade subclinical smoldering inflammation and morbid biology in individuals with risk factors for atherosclerosis.
authors.affiliation: Department of Internal Medicine 'D', Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.
authors.forename: Rivka
authors.initials: R
authors.lastname: Rotstein
authors.forename: Tali
authors.initials: T
authors.lastname: Landau
authors.forename: Abraham
authors.initials: A
authors.lastname: Twig
authors.forename: Ardon
authors.initials: A
authors.lastname: Rubinstein
authors.forename: Michael
authors.initials: M
authors.lastname: Koffler
authors.forename: Daniel
authors.initials: D
authors.lastname: Justo
authors.forename: Doron
authors.initials: D
authors.lastname: Constantiner
authors.forename: David
authors.initials: D
authors.lastname: Zeltser
authors.forename: Itzhak
authors.initials: I
authors.lastname: Shapira
authors.forename: Tamar
authors.initials: T
authors.lastname: Mardi
authors.forename: Yelena
authors.initials: Y
authors.lastname: Goldin
authors.forename: Shlomo
authors.initials: S
authors.lastname: Berliner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology; D002784:Cholesterol / Q000097:blood*; D004903:Erythrocyte Aggregation; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D002097:C-Reactive Protein; D002784:Cholesterol