title: Evidence that nitric oxide regulates cell-cycle progression in the developing chick neuroepithelium.
abstract: In all developing epithelia, the nuclei continually migrate between the apical and basal sides of the cell during the cell cycle, with S phase occurring basally and mitosis occurring apically. The purpose and mechanism of this nuclear migration are unknown. Here, we show that nitric oxide (NO) is endogenously produced in the developing chicken neural tube, where it apparently regulates cell-cycle progression. We provide evidence that high NO levels promote entry into S phase basally, whereas low levels of NO facilitate entry into mitosis apically.
authors.affiliation: Department of Cell Research and Immunology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Traister
authors.forename: Soulico
authors.initials: S
authors.lastname: Abashidze
authors.forename: Veronica
authors.initials: V
authors.lastname: Gold
authors.forename: Nicolas
authors.initials: N
authors.lastname: Plachta
authors.forename: Esther
authors.initials: E
authors.lastname: Karchovsky
authors.forename: Ketan
authors.initials: K
authors.lastname: Patel
authors.forename: Miguel
authors.initials: M
authors.lastname: Weil
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology*; D002642:Chick Embryo; D004847:Epithelial Cells / Q000166:cytology / Q000201:enzymology; D008938:Mitosis / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D016196:S Phase / Q000502:physiology*; D019170:Somites / Q000166:cytology / Q000201:enzymology
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase