Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions.
Comparative study of plasma activities of enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions revealed significant differences between intact BALB/c and C57Bl/6 mice by the half-life of plasma leu-enkephalin. Selank in a dose of 100 micrograms/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice, but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice. Our results suggest that anxiolytic activity of Selank is associated with inhibition of enkephalin-degrading enzymes.
Sokolov
O Yu
OY
Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow. sokolov@rcmh.msk.ru
Meshavkin
V K
VK
Kost
N V
NV
Zozulya
A A
AA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D004743:Enkephalin, Leucine / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*; D015260:Neprilysin / Q000097:blood*; D009842:Oligopeptides / Q000494:pharmacology*; D010641:Phenotype; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology*
D014151:Anti-Anxiety Agents; D009842:Oligopeptides; D004743:Enkephalin, Leucine; D015260:Neprilysin; C100827:TP 7