title: Compulsions, Parkinson's disease, and stimulation.
abstract: Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.
authors.affiliation: CNRS UMR 7593 and Service de Psychiatrie, Pavillon Clérambault, GH Pitié-Salpêtrière, Hôpital de la Salpêtrière, Assistance Publique-Hôpital de Paris, 75651 Cedex 13, Paris, France. lucmallet@free.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Mallet
authors.forename: Valérie
authors.initials: V
authors.lastname: Mesnage
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Houeto
authors.forename: Antoine
authors.initials: A
authors.lastname: Pelissolo
authors.forename: Jérôme
authors.initials: J
authors.lastname: Yelnik
authors.forename: Cécile
authors.initials: C
authors.lastname: Behar
authors.forename: Marcella
authors.initials: M
authors.lastname: Gargiulo
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Welter
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Bonnet
authors.forename: Bernard
authors.initials: B
authors.lastname: Pillon
authors.forename: Philippe
authors.initials: P
authors.lastname: Cornu
authors.forename: Didier
authors.initials: D
authors.lastname: Dormont
authors.forename: Bernard
authors.initials: B
authors.lastname: Pidoux
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Allilaire
authors.forename: Yves
authors.initials: Y
authors.lastname: Agid
mesh_terms: D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000628:therapy*; D010300:Parkinson Disease / Q000150:complications* / Q000628:therapy*; D020531:Subthalamic Nucleus