New cholinesterase inhibiting steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
From the leaves of Sarcococca coriacea two new steroidal alkaloids, epoxynepapakistamine-A [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-16alpha,17alpha-epoxy-2beta,4beta-di-O-acetate] (1), and epoxysarcovagenine-D [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-2-en-16alpha,17alpha-epoxy-4-one] (2), and two known compounds funtumafrine C [(20S)-20-(N,N-dimethylamino)-5alpha-pregna-3-one] (3) and N-methylfuntumine (4) were isolated. Their structures were elucidated on the basis of their spectral properties. The compounds 1, 3 and 4 were found to have cholinesterase inhibitory activity when tested for the inhibition of electric eel acetylcholinesterase and horse serum butyrylcholinesterase. They inhibited both enzymes in a concentration dependent fashion.
Kalauni
Surya K
SK
Central Department of Chemistry, Tribhuvan University, Nepal.
Choudhary
Muhammad Iqbal
MI
Khalid
Asaad
A
Manandhar
Mangala Devi
MD
Shaheen
Farzana
F
Atta-ur-Rahman
Gewali
Mohan Bikram
MB
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D031234:Buxaceae / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D009390:Nepal; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D013256:Steroids