Changes in the count of pancreatic beta- and alpha-cells and blood glucose level in rats with alloxan-induced diabetes.
We estimated the count of pancreatic alpha- and beta-cells and blood glucose level at various stages of alloxan-induced diabetes in rats. Alloxan decreased the count of insulin-producing beta-cells, but increased the number of glucagon-secreting alpha-cells in the pancreas (week 1 of diabetes). These changes were accompanied by hyperglycemia. The decrease in blood glucose level in diabetic rats was associated with an increase in beta-cell count against the background of high density of pancreatic alpha-cells.
Aleeva
G N
GN
Department of Normal Human Anatomy, Department of Pathophysiology, Department of Pharmacology, Kazan State Medical University.
Kiyasov
A P
AP
Minnebaev
M M
MM
Burykin
I M
IM
Khafiz'yanova
R Kh
RKh
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051381:Rats
D001786:Blood Glucose