title: The tethered aminohydroxylation (TA) of cyclic allylic carbamates.
abstract: The tethered aminohydroxylation of cyclic allylic carbamates is described using catalytic amounts of potassium osmate. The mechanism of reaction involves formation of an imido-osmium complex which adds intramolecularly to alkenes with complete control of both regio- and stereoselectivity: the formation of syn-aminodiol motifs is now straightforward using this chemistry. Proof of the mechanism was obtained with an X-ray crystal structure of an azaglycolate osmate ester intermediate.
authors.affiliation: Dyson Perrins Laboratory, South Parks Road, Oxford, OX1 3QY, UK. timothy.donohoe@chem.ox.ac.uk
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Donohoe
authors.forename: Peter D
authors.initials: PD
authors.lastname: Johnson
authors.forename: Andrew
authors.initials: A
authors.lastname: Cowley
authors.forename: Martine
authors.initials: M
authors.lastname: Keenan