title: Efficient routine production of the 18F-labelled amino acid O-2-18F fluoroethyl-L-tyrosine.
abstract: A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application.
authors.affiliation: Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425, Jülich, Germany. k.hamacher@fz-juelich.de
authors.forename: K
authors.initials: K
authors.lastname: Hamacher
authors.forename: H H
authors.initials: HH
authors.lastname: Coenen
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004735:Energy Transfer; D005461:Fluorine / Q000737:chemistry*; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D005461:Fluorine; D014443:Tyrosine