title: [Study on intervention and comparison of rational use of antibiotics on perioperative period of clean incision and clean-defiled incision].
abstract: OBJECTIVE
  To explore a set of scientific evaluation and intervention methods on perioperatur period which fits for China's situation, and to promote the development of rational drug use.
  
  
  METHODS
  Two would tertiary general hospitals were selected and separated in to intervention group and control group. Intervention was carried out and compared at the same period on inpatient surgical cases of thryroidectomy, mastectomy, cholescystectomy, and hysteromyomectomy plus appendix.
  
  
  RESULTS
  The average drug costs was decreased from 1 601.27 yuan to 1 489.59 yuan and the average antibiotics use from 740.20 yuan to 352.03 yuan (P < 0.01) in the intervention group pre and post intervention. There was a remarkable improvement on the rationality of antibiotics use in intervention group, from 31.35% to 91.81% (P < 0.01) pre and post intervention, implemented in the hospital.
  
  
  CONCLUSIONS
  It is practicable and effective to implement rational drug use where intervention was carried out, since it plays an active role on promoting safely, effectively and economic antibiotic use in China.
authors.affiliation: Department of Pharmacy, Xuanwu Hospital of the Capital University of Medical Sciences, Beijing 100053, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Wang
authors.forename: Lihong
authors.initials: L
authors.lastname: Wang
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Xu
authors.forename: Shujie
authors.initials: S
authors.lastname: Wang
authors.forename: Jialin
authors.initials: J
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Haiou
authors.initials: H
authors.lastname: Shi
authors.forename: Hailian
authors.initials: H
authors.lastname: Wang
authors.forename: Jingli
authors.initials: J
authors.lastname: Zhang
authors.forename: Lianzhen
authors.initials: L
authors.lastname: Chen
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use*; D016527:Drug Costs; D004363:Drug Utilization / Q000191:economics; D013502:General Surgery; D006801:Humans; D019990:Perioperative Care
chemical_list: D000900:Anti-Bacterial Agents