title: Phenobarbitone prophylaxis for neonatal jaundice in babies with birth weight 1000-1499 grams.
abstract: Management of neonatal jaundice is simple but in sick, very low birth weight babies poses additional hemodynamic insult. Role of prophylactic postnatal phenobarbitone (two different dosage regimens) was evaluated prospectively on occurrence of neonatal jaundice and the need for therapy in 150 babies with birth weight 1000-1499 grams. Phenobarbitone in the dose of 10mg/kg given within 6 hours of life followed by 5mg/kg/day till day 5 of life intravenously significantly decreased the need for exchange transfusion and duration of phototherapy in babies with birth weight of 1000-1499 grams. This dosage schedule was better than dose of 5mg/kg for 5 days in significantly reducing the duration of phototherapy
authors.affiliation: Division of Neonatology, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Anil
authors.initials: A
authors.lastname: Narang
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
authors.forename: Gurjeevan
authors.initials: G
authors.lastname: Garewal
mesh_terms: D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000517:prevention & control*; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D010789:Phototherapy; D011446:Prospective Studies
chemical_list: D010634:Phenobarbital