title: Association between relative temporal and prefrontal sulcal cerebrospinal fluid and illness duration in schizophrenia.
abstract: Changes in sulcal cerebrospinal fluid (CSF) volume have been related to the neurodegeneration hypothesis in schizophrenia. Fifty-three (24 neuroleptic-naive) schizophrenics and a control group (n=26) were studied with MRI to assess regional sulcal CSF values relative to the total volume of brain lobes (prefrontal, orbital, temporal, parietal, and occipital). Segmentation of brain structures was performed using an automatic Talairach-based method. Relative CSF volumes were adjusted for age by means of linear regression from normal subjects; the corrected values were used to assess their relationship with illness duration and age of onset (AOS). The volume of sulcal CSF on prefrontal and temporal lobes (bilateral) was significantly greater in schizophrenic patients and showed a significant positive correlation with illness duration not found in the other regions studied. No significant association between CSF volumes and AOS was found in any region. Our findings support the existence of a degenerative process in schizophrenia located in prefrontal and temporal areas.
authors.affiliation: Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda de Córdoba, km 5.4, 28041, Madrid, Spain. vmolina@mx3.redestb.es
authors.forename: Vicente
authors.initials: V
authors.lastname: Molina
authors.forename: Santiago
authors.initials: S
authors.lastname: Reig
authors.forename: Javier
authors.initials: J
authors.lastname: Sanz
authors.forename: Carlos
authors.initials: C
authors.lastname: Benito
authors.forename: Javier
authors.initials: J
authors.lastname: Pascau
authors.forename: Francisco
authors.initials: F
authors.lastname: Collazos
authors.forename: Fernando
authors.initials: F
authors.lastname: Sarramea
authors.forename: Juan F
authors.initials: JF
authors.lastname: Artaloytia
authors.forename: Juan D
authors.initials: JD
authors.lastname: Gispert
authors.forename: Rogelio
authors.initials: R
authors.lastname: Luque
authors.forename: Tomás
authors.initials: T
authors.lastname: Palomo
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000378:metabolism*; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000188:drug therapy; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents