[A molecular epidemiological study of childhood lead poisoning in lead-polluted environment].
OBJECTIVE
The relationship between polymorphisms of ALAD and VDR genes and individual susceptibility of lead poisoning was investigated in children highly-exposed to lead.


METHODS
Four hundred and sixty-nine children were recruited into this study and the blood lead, ZPP, hemoglobin as well as three physical developmental indexes (head circumference, height and weight) were measured. VDR and ALAD gene polymorphisms were analyzed by the methods of PCR-RFLP.


RESULTS
The subjects with ALAD2 allele had higher ZPP level (10.12 micro mol/L vs 12.87 micro mol/L) (P = 0.017). The subjects with B allele has larger head circumference than only with b allele (51.19 cm vs 50.75 cm) (P = 0.028).


CONCLUSIONS
It was suggested that the ALAD gene polymorphism modified the relationship between blood lead and ZPP and the VDR gene variants influenced the skull development in children living under lead-polluted environment. The polymorphism of ALAD and VDR genes might serve as the molecular inherited factors modifying the susceptibility of lead poisoning.
Zheng
Yuxin
Y
Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Leng
Shuguang
S
Song
Wenjia
W
Wang
Yawen
Y
Niu
Yong
Y
Zhang
Wenzhong
W
Yan
Huifang
H
Liu
Yuying
Y
Huang
Qingxiao
Q
Wu
Yiqun
Y
D000483:Alleles; D001827:Body Height / Q000187:drug effects / Q000235:genetics; D001835:Body Weight / Q000187:drug effects / Q000235:genetics; D002648:Child; D002681:China / Q000453:epidemiology; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D007855:Lead Poisoning / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D000623:Porphobilinogen Synthase / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics
D018167:Receptors, Calcitriol; D007854:Lead; D000623:Porphobilinogen Synthase