Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus.
Recent studies have shown that neurofibrillary tangles frequently coexist with alpha-synuclein (alpha-S)-positive fibrillary inclusions in the limbic system in Alzheimer's disease. To elucidate whether alpha-, beta- and gamma-S immunoreactivity is present in Pick bodies (PBs), we examined immunohistochemically and immunoelectron microscopically the brains from three patients with Pick's disease. Numerous PBs were distributed widely, and were occasionally immunoreactive for alpha-S and beta-S, but not for gamma-S in all three cases. However, these immunoreactive PBs were almost all restricted to the dentate gyrus. Despite the co-localization of phosphorylated tau and alpha-S or beta-S (as evidenced by double-labeling immunohistochemistry), immunoelectron microscopy revealed that alpha-S and beta-S immunoreactivity occurs in granular and vesicular structures, but not in filamentous structures. These findings suggest that alpha-S and beta-S are up-regulated in the neuronal perikarya but they are not incorporated into the constituent filaments of PBs, and that the preferential distribution of alpha-S- and beta-S-positive PBs in the dentate gyrus may represent the cellular response to PB formation in this particular system.
Mori
Fumiaki
F
Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan. neuropal@cc.hirosaki-u.ac.jp
Hayashi
Shintaro
S
Yamagishi
Shin-Ichiro
S
Yoshimoto
Makoto
M
Yagihashi
Soroku
S
Takahashi
Hitoshi
H
Wakabayashi
Koichi
K
D000368:Aged; D018891:Dentate Gyrus / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010766:Phosphorylation; D020774:Pick Disease of the Brain / Q000378:metabolism*; D051843:Synucleins; D051844:alpha-Synuclein; D051846:beta-Synuclein; D016875:tau Proteins / Q000096:biosynthesis
D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; C497607:SNCB protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D051846:beta-Synuclein; D016875:tau Proteins