[Treatment of Bell's palsy with acyclovir and methylprednisolone].
OBJECTIVE
An open therapeutic trial was conducted in patients with Bell's palsy. Results were compared with data in the literature.


METHODS
Between 1997 and 2000, 76 patients with Bell's palsy were treated with intravenous methylprednisolone (2 mg/kg/day) and acyclovir (5-10 mg/kg/8 hours) for 7 days. Treatment was initiated in all patients before the 14th day of illness. Severity of the palsy was scored on the first day of treatment and again one year later using the House and Brackman scale.


RESULTS
Grade II or III palsy were observed in 38% of the patients at initial presentation, grades IV to VI in 62%. After treatment, 92% of the patients had reverted to grades I and II (good outcome) and only 8% had sequelae at 1-year follow-up. All patients with initial grade I or II recovered completely. For patients with grade IV, V, or VI complete recovery at 1 year was observed in 94, 86 and 50% respectively.


CONCLUSIONS
Data in the literature suggest that corticosteroids should improve recovery in Bell's plasy. In our study, adjunction of acyclovir did not demonstrate any clear improvement in the cure rate. Benefit could depend on early prescription.
Lejeune
D
D
Service d'ORL et de Chirurgie Cervico-Faciale, France.
Bernat
I
I
Vitte
E
E
Lamas
G
G
Willer
J C
JC
Soudant
J
J
Tankéré
F
F
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020330:Bell Palsy / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D000212:Acyclovir; D008775:Methylprednisolone