title: Transplantation of pediatric en bloc cadaver kidneys into adult recipients: a single-center experience.
abstract: Faced with an extreme shortage of organs transplant professionals continue to explore various strategies to expand the donor pool. Transplantation of kidneys from older and very young donors are two such options. Although kidneys from young donors (less than 5 years of age) have been associated with a high rate of technical complications and suboptimal results, use of these kidneys en bloc has been advocated to improve the outcomes. We reviewed our experience with en bloc kidney transplantation at the University of Kentucky over the past 10 years. Between 1991 and 2000 ten patients underwent kidney transplantation using kidneys en bloc from donors <5 years age. The mean age of the donors was 2.8 years with a mean weight of 16 kg (range 13-21). Mean age of the recipients was 42 years. One patient lost the graft on day one from venous thrombosis. One patient lost the graft 7 years post-transplant from chronic rejection. All of the remaining patients are doing well with functioning grafts (mean follow-up 4.5 years; range 6 months to 10 years). Both one-year and five-year graft survival rates are 89 per cent. The present study confirms that excellent results can be achieved with kidney transplantation using kidney transplantation using kidneys en bloc from donors younger than 5 years of age.
authors.affiliation: Department of Surgery, University of Kentucky, Lexington 40503, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Ruff
authors.forename: K Sudhakar
authors.initials: KS
authors.lastname: Reddy
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Johnston
authors.forename: Thomas
authors.initials: T
authors.lastname: Waid
authors.forename: Wade
authors.initials: W
authors.lastname: McKeown
authors.forename: Taqi
authors.initials: T
authors.lastname: Khan
authors.forename: Dinesh
authors.initials: D
authors.lastname: Ranjan
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Lucas
mesh_terms: D000328:Adult; D000367:Age Factors; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome