Deamidation of Bcl-X(L): a new twist in a genotoxic murder mystery.
Bcl-2 proteins are critical regulators of apoptosis following DNA damage. Recent studies have shown that genotoxic stress induces the deamidation of Bcl-X(L), inhibiting its antiapoptotic activities. Remarkably, Rb and p53 are important regulators of this novel modification of Bcl-X(L).
Johnstone
Ricky W
RW
Cancer Immunology Program, Peter MacCallum Cancer Institute, East Melbourne, 3002, Victoria, Australia.
D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D004249:DNA Damage; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051020:bcl-X Protein
C494811:BCL2L1 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; D051020:bcl-X Protein