title: Inhibitory receptors and allergy.
abstract: Recent studies of the major cell types involved in the initiation and progression of allergic inflammation have revealed that they express an unexpectedly large number of surface receptors that inhibit the release of proinflammatory mediators from mast cells and basophils in vitro. Moreover, analyses of animals deficient in some of these receptors, for example, Fc(gamma)RIIB, gp49B1 and paired Ig-like receptor (PIR)-B, have shown that the molecules indeed suppress allergic responses driven by the adaptive immune response in vivo. These findings support the emerging concept that allergic diseases are caused not only by excessive activation of cells but also from deficiencies in receptors that suppress these activation responses.
authors.affiliation: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. hrkatz@mbcrr.harvard.edu
authors.forename: Howard R
authors.initials: HR
authors.lastname: Katz
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D037102:Lectins / Q000276:immunology; D037181:Lectins, C-Type / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D019158:N-Acetylneuraminic Acid / Q000276:immunology; D051381:Rats; D017452:Receptors, IgG / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology*; D015534:Trans-Activators
chemical_list: D015703:Antigens, CD; C080571:Fc gamma receptor IIB; C489447:Gp49a protein, mouse; C113413:KLRG1 protein, human; C451496:Klrg1 protein, mouse; C094696:Klrg1 protein, rat; D037102:Lectins; D037181:Lectins, C-Type; C489448:Lilrb4 protein, mouse; D008562:Membrane Glycoproteins; C105949:Pirb protein, mouse; C491380:Pirb protein, rat; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D015534:Trans-Activators; D019158:N-Acetylneuraminic Acid