title: Brain metastases in melanoma: a European perspective.
abstract: CNS involvement is a common feature of metastatic melanoma. Despite this, there is little evidence upon which clinicians can base decisions about treatment. The short prognosis and significant symptoms usually associated with melanoma brain metastases have excluded these patients from clinical trials. In Europe the standard treatment involves whole brain radiotherapy, although selected centers offer other modalities, including surgery, radiosurgery, and chemotherapy.
authors.affiliation: Cancer Research UK Medical Oncology Unit, Churchill Hospital, Oxford, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Cattell
authors.forename: Charles
authors.initials: C
authors.lastname: Kelly
authors.forename: Mark R
authors.initials: MR
authors.lastname: Middleton
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy*; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D006801:Humans; D008545:Melanoma / Q000556:secondary* / Q000628:therapy*; D016634:Radiosurgery; D012878:Skin Neoplasms / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents