[Mechanisms of lability of neurological symptoms in multiple sclerosis].
Pathophysiological peculiarities of demyelinated axons determine their high sensitivity to different exogenous factors and are the reason of instability of neurological signs in MS. One of the typical MS sing is high sensitivity to elevated temperature of the body. Even temporary elevation in body temperature may cause changes in impulse conduction in demyelinated fibres, which was proved by studies of evoked potentials and stabilometric studies. These disturbances may be associated with disorder of ions channels function. The role of other factors (metabolic and immunological disturbances, levels of cytokines and neurotransmitters) in temporary block of nerve conduction in MS is discussed. Further studies of the mechanisms of the lability of neurological sings in MS may lead to elaboration of new approaches to MS treatment.
Peresedova
A V
AV
Baĭdina
E V
EV
Trifonova
O V
OV
Aĭzenberg
I V
IV
Gnezditskiĭ
V V
VV
Barkhatova
V P
VP
Chernikova
L A
LA
Zavalishin
I A
IA
D000328:Adult; D001369:Axons / Q000473:pathology; D001831:Body Temperature / Q000502:physiology; D003711:Demyelinating Diseases / Q000473:pathology; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D012720:Severity of Illness Index
D007473:Ion Channels