Cytokines in immunotherapy of experimental uveitis.
A better understanding of the basic mechanisms of uveitis and of the role of cytokines in experimental ocular inflammation autoimmune diseases should allow us to define new approaches for therapy. Modulation of the cytokine network by either blocking cytokine activity or administration of regulatory Th2 cytokines has shown its efficacy in several experimental autoimmune diseases including uveitis. However, cytokines present pleiotropic activities and thus may exert different effects depending on the autoimmune diseases, making interventions on their production complex. Anti-cytokine therapy or a combination of anti-cytokine drugs, antibodies, and cytokine gene therapy to synergize the therapeutical effects of other treatments appear to be of interest. Improvements in drug delivery and in biotechnology will also allow us to elaborate new and safe immunomodulatory strategies.
de Kozak
Yvonne
Y
INSERM U450, Paris, France. ydekozak@ccr.jussieu.fr
Verwaerde
Claudie
C
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000502:physiology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007371:Interferon-gamma / Q000502:physiology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D016753:Interleukin-10 / Q000627:therapeutic use; D018793:Interleukin-13 / Q000627:therapeutic use; D007376:Interleukin-2 / Q000037:antagonists & inhibitors; D015847:Interleukin-4 / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014605:Uveitis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D000093242:Interleukin-6 Inhibitors
D016207:Cytokines; D007371:Interferon-gamma; D007375:Interleukin-1; D016753:Interleukin-10; D018793:Interleukin-13; D007376:Interleukin-2; D015847:Interleukin-4; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors