title: The expression of sialyl Lewis X in canine and feline mammary gland tumors.
abstract: The expression of sialyl Lewis X (sLe(x)) in 93 canine and 15 feline mammary gland tumors (MGT) obtained by surgical resection at Veterinary Medical Center, the University of Tokyo was examined by immunohistochemistry. Their clinicopathological features and prognosis were also reviewed. Approximately 60% of MGT tissues showed sLe(x) positive expressions, while all normal mammary gland tissues were negative. However, its expression was not correlated with clinicopathological features and prognosis significantly. This study suggests that sLe(x) may be a tumor-associated antigen in canine and feline MGTs.
authors.affiliation: Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Rina
authors.initials: R
authors.lastname: Uyama
authors.forename: Emi
authors.initials: E
authors.lastname: Ohashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takahashi
authors.forename: Sung Hyeol
authors.initials: SH
authors.lastname: Hong
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Ryouhei
authors.initials: R
authors.lastname: Nishimura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000378:metabolism*; D002415:Cats; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D008321:Mammary Glands, Animal / Q000378:metabolism / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000737:chemistry* / Q000473:pathology; D009844:Oligosaccharides / Q000032:analysis* / Q000096:biosynthesis; D000080506:Sialyl Lewis X Antigen
chemical_list: D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen