title: Implications from a field study regarding the relationship between polycyclic aromatic hydrocarbons and glutathione S-transferase activity in mussels.
abstract: An aluminium smelter on the west coast of Scotland discharges an aqueous effluent containing polycyclic aromatic hydrocarbons (PAHs) at the head of Loch Leven. The loch also supports two mussel (Mytilus edulis) farms. Data are presented on burdens of PAHs in the soft tissues of mussels and the effect of these contaminants on glutathione S-transferase (GST) activity in mussel hepatopancreas. GST activity is shown to be correlated with total PAH burden and also with the concentrations of certain individual PAHs. These field data show that high molecular weight PAHs are closely correlated to GST activity, whereas low molecular weight PAHs are not. This suggests that 5- and 6-ring PAHs have a more pronounced role than 2- to 4-ring compounds in inducing GST activity in mussels from Loch Leven. It is proposed that it may be more appropriate to link GST activity with 5- and 6-ring compounds only, rather than with the total PAH burden.
authors.affiliation: FRS Marine Laboratory, Aberdeen, UK. gowlandb@marlab.ac.uk
authors.forename: B T G
authors.initials: BT
authors.lastname: Gowlan
authors.forename: A D
authors.initials: AD
authors.lastname: McIntosh
authors.forename: I M
authors.initials: IM
authors.lastname: Davies
authors.forename: C F
authors.initials: CF
authors.lastname: Moffat
authors.forename: L
authors.initials: L
authors.lastname: Webster
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000502:physiology*; D005982:Glutathione Transferase / Q000187:drug effects* / Q000494:pharmacology*; D007220:Industrial Waste; D008669:Metallurgy; D008970:Molecular Weight; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
chemical_list: D007220:Industrial Waste; D011084:Polycyclic Aromatic Hydrocarbons; D005982:Glutathione Transferase