title: [Etiological diagnosis of isolated stenosis of the aortic valve].
abstract: We tried to objectivize etiologic diagnosis of isolated aortic stenosis. We studied 950 valves removed during operation on the heart and 15 valves of the dead patients without cardiac pathology using automatic semi-quantitative microscopic description of the valve pathology with further calculation of informative value of the signs. As a result of our investigation the list of the most important signs for the differential diagnosis was compiled. We found out that most often causes of aortic stenosis are calcinosis of bicuspid aortic valve and senile calcinosis. Silvering of the nucleolus organiser in endotheliocytes and fibroblasts in various pathology of the aortic valve showed an increase in the metabolism level and plastic possibilities of the cells in aortic calcinosis.
authors.affiliation: Research Institute of Cardiology, 194156, St-Petersburg.
authors.forename: L B
authors.initials: LB
authors.lastname: Mitrofanova
authors.forename: G B
authors.initials: GB
authors.lastname: Koval'skiĭ
mesh_terms: D001021:Aortic Valve / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000209:etiology*; D002114:Calcinosis / Q000150:complications*; D009202:Cardiomyopathies / Q000150:complications*; D003937:Diagnosis, Differential; D006801:Humans; D008875:Middle Aged