Dam1 is the right one: phosphoregulation of kinetochore biorientation.
Chromosomes have to establish the proper attachment to the spindle before segregation-a process that requires Ipl1p Aurora kinase. Recent work has identified Dam1p, a member of the DASH complex, as the key Ipl1p substrate responsible for kinetochore/microtubule interaction.
Courtwright
Andrew M
AM
Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston Medical School, 6431 Fannin, 6.200, Houston, TX 77030, USA.
He
Xiangwei
X
D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D018386:Kinetochores / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
C447843:ASK1 protein, S cerevisiae; D018797:Cell Cycle Proteins; C116003:DAM1 protein, S cerevisiae; D005656:Fungal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases; D064127:Aurora Kinases; C576961:IPL1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases