title: [A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
abstract: We administered pharmacokinetic modulating chemotherapy (PMC, oral tegafur/uracil [UFT] plus fluorouracil infusion) together with irinotecan hydrochloride (CPT-11) in a patient with rectal cancer, who had multiple lung metastases at 2 years and 7 months after surgery. However, because the patient showed resistance, we attempted combination therapy with CPT-11 and doxifluridine (5'-DFUR) on an outpatient basis, which resulted in NC after 9 months. During this period, the therapy was performed safely without any observable adverse reactions such as diarrhea or myelosuppression. This case suggests the efficacy of combination therapy with CPT-11 and 5'-DFUR, which was expected since this is an established treatment for progressive recurrent colon cancer.
authors.affiliation: 2nd Dept. of Surgery, Mie University School of Medicine.
authors.forename: Eiki
authors.initials: E
authors.lastname: Ojima
authors.forename: Chikao
authors.initials: C
authors.lastname: Miki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hatada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Inoue
authors.forename: Tomomi
authors.initials: T
authors.lastname: Mohri
authors.forename: Takaaki
authors.initials: T
authors.lastname: Azuma
authors.forename: Masato
authors.initials: M
authors.lastname: Kusunoki
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005467:Floxuridine / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C096910:UFT(R) drug; D005467:Floxuridine; D005641:Tegafur; D014498:Uracil; D000077146:Irinotecan; D005472:Fluorouracil; C025034:doxifluridine; D002166:Camptothecin