[Influence of immunosuppressors on remodeling of extracellular matrix in experimental nephropathies].
Influence of methylprednisolone (MP) and cyclosporine A (CsA) on the extracellular matrix and growth factors was studied on the model of rapid nephrotoxic nephritis (RNN) and puromycin-aminonucleoside nephrosis (PAN). MP decreased accumulation of type IV collagen in RNN and increased the content of laminine in both models. CsA decreased deposits of type IV collagen but increased accumulation of fibronectin in both models. CsA reduced the content of a free form of oPRP in both models but MP did so in RNN only. CsA and MP decreased the level of active PRP in both models but MP did so in RNN only. CsA and MP decreased the level of active TPR-beta and increased the content of latent forms but CsA was more active in PAN. In experimental models of inflammatory RNN and non-inflammatory CPAN nephropathy CsA raised fibronectin production, MP increased deposition of laminine. CsA in both models suppressed production of basic fibrogenic factor TPR-beta while MP inhibited this in RNN only.
Pal'tseva
E M
EM
Research Institute of Molecular Medicine of I.M. Sechenov Moscow Medical Academy, 117418, Moscow.
Gladskikh
O P
OP
Ivanov
A A
AA
D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000187:drug effects* / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D005920:Glomerular Mesangium / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005921:Glomerulonephritis / Q000378:metabolism*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007375:Interleukin-1 / Q000378:metabolism; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000378:metabolism
D007166:Immunosuppressive Agents; D007375:Interleukin-1; D016212:Transforming Growth Factor beta; D016222:Fibroblast Growth Factor 2; D016572:Cyclosporine; D008775:Methylprednisolone