Novel and efficient synthesis of 4-dimethylamino-2-glycosylaminoquinazolines by cyclodesulfurization of glycosyl thioureas with dimethylcyanamide.
4-dimethylamino-2-glycosylaminoquinazoline derivatives were synthesized by cyclodesulfurization of N-aryl-N'-glycosyl thioureas with dimethylcyanamide in the presence of silver triflate in good yields.
Gama
Yasuo
Y
National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, Ibakari, Japan. y-gamma@aist.go.jp
Shibuya
Isao
I
Shimizu
Masao
M
D000634:Aminoquinolines / Q000138:chemical synthesis / Q000737:chemistry; D003484:Cyanamide / Q000138:chemical synthesis* / Q000737:chemistry; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000634:Aminoquinolines; D011799:Quinazolines; C011787:dimethylcyanamide; D003484:Cyanamide; D013890:Thiourea