Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats.
Vilon (Lys-Glu) and Epithalon (Ala-Glu-Asp-Gly) administered orally for 1 month improved transport characteristics of the small intestine in aged rats. Vilon enhanced passive glucose accumulation in the serous fluid in inverted sac made from the distal region of the small intestine, while Epithalon enhanced this process in the medial region. Vilon stimulated active glucose accumulation in the serous sac of the medial small intestine, Epithalon - in the proximal and distal small intestinal segments. Glycine absorption increased only in the proximal intestinal segment under the effect of Epithalon.
Khavinson
V Kh
VKh
St. Petersburg Institute of Bioregulation and Gerontology, North-West Department of the Russian Academy of Medical Sciences, St. Petersburg.
Egorova
V V
VV
Timofeeva
N M
NM
Malinin
V V
VV
Gordova
L A
LA
Gromova
L V
LV
D000042:Absorption; D000818:Animals; D001692:Biological Transport; D001835:Body Weight / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry; D051381:Rats; D013997:Time Factors
D004151:Dipeptides; D009842:Oligopeptides; D010455:Peptides; C415909:lysylglutamic acid; D005947:Glucose; C421253:alanyl-glutamyl-aspartyl-glycine; D005998:Glycine