Wavefront aberrations measured with Hartmann-Shack sensor in patients with keratoconus.
OBJECTIVE
To compare the ocular wavefront aberrations of normal and keratoconic eyes and to describe the characteristics of the higher-order aberrations in eyes with keratoconus.


METHODS
Prospective case control and observational study.


METHODS
Thirty-five keratoconic eyes and thirty-eight normal controls.


METHODS
Higher-order aberrations in refraction were measured with a wavefront sensor, and those aberrations resulting from the cornea were evaluated by videokeratographic data.


METHODS
Coma-like (S(3 + 5)), spherical-like (S(4 + 6)), and total (S(3 + 4 + 5 + 6)) higher-order aberrations in both refraction and the cornea.


RESULTS
The mean +/- standard deviation of S(3 + 5) (1.88 +/- 1.16), S(4 + 6) (0.70 +/- 0.55), and S(3 + 4 + 5 + 6) (2.03 +/- 1.23) in refraction (6-mm diameter, root mean square, micro m) were significantly higher in the keratoconic eyes than in normal controls (0.26 +/- 0.10, 0.19 +/- 0.10, 0.34 +/- 0.11, respectively; Mann-Whitney U test, P = 0.001). Coma-like aberrations were 2.32 times larger than spherical-like aberrations in keratoconic eyes.


CONCLUSIONS
The increase of ocular higher-order aberrations in keratoconic eyes results from an increase of corneal higher-order aberrations. Coma-like aberrations were dominant compared with spherical-like aberrations in keratoconic eyes. Wavefront sensing will enable us not only to evaluate the quality of vision but also to differentiate keratoconic eyes from normal eyes by analyzing the characteristics of the higher-order aberrations.
Maeda
Naoyuki
N
Department of Ophthalmology, Osaka University Medical School, Suita, Japan. nmaeda@ophthal.med.osaka-u.ac.jp
Fujikado
Takashi
T
Kuroda
Teruhito
T
Mihashi
Toshifumi
T
Hirohara
Yoko
Y
Nishida
Kohji
K
Watanabe
Hitoshi
H
Tano
Yasuo
Y
D000328:Adult; D001251:Astigmatism / Q000175:diagnosis*; D016022:Case-Control Studies; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000473:pathology*; D008297:Male; D011446:Prospective Studies