B-Cell lymphoproliferative disorder not associated with Epstein-Barr Virus in a child with relapsed acute lymphoblastic leukemia.
Lymphoproliferative disorder (LPD) is described in only a few children receiving chemotherapy for cancer. In all of them, an association between LPD and EBV (Epstein-Barr Virus) was found. We report on a patient who developed LPD not associated with EBV while receiving chemotherapy for relapsed acute lymphoblastic leukemia (ALL). Despite discontinuation of chemotherapy, administration of intravenous immunoglobulins and surgery the patient died. Growing experience with this disorder may allow better treatment options in the future and will show whether LPD not associated with EBV requires different therapeutic strategies.
Lehrnbecher
Thomas
T
Department of Pediatrics, University of Würzburg, Germany. thomas_lehrnbecher@yahoo.com
Trusen
Andreas
A
Deinlein
Frank
F
Höcht
Burkhard
B
Marx
Alexander
A
Kühl
Joachim
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes; D002675:Child, Preschool; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000601:surgery; D014412:Tumor Virus Infections / Q000209:etiology*