title: The effect of para-aminobenzoic acid on growth and metabolism of Porphyromonas gingivalis.
abstract: OBJECTIVE
  To study the effect of para-aminobenzoic acid (PABA) on the growth and metabolism of Porphyromonas gingivalis (P.g).
  
  
  METHODS
  After adding different concentrations of PABA into the medium, anaerobic technique was applied to culture P.g. The products' A value and action of TLP was assayed, and P.g grew in the medium was observed by a scanning electron microscope.
  
  
  RESULTS
  PABA promoted the growth of P.g and action of TLP, which would reach the highest level when PABA was 1 mg/L, and would decrease with the increasing of concentration of PABA. When the concentration arrived at 100 mg/L, PABA had no effect on them. In the mean time, PABA had effect on the form and adherence of P.g. When the concentration was 1 mg/L and 100 mg/L, this effect was strong, but as the concentration was 10 mg/L, the effect disappeared.
  
  
  CONCLUSIONS
  PABA influences the growth and metabolism of P.g, which indicate that Streptococcus sanguis has regulative effect on the microecology of subgingival plaque.
authors.affiliation: Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Zhou
authors.forename: Zhiling
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiyao
authors.initials: J
authors.lastname: Li
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Xiao
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
mesh_terms: D010129:4-Aminobenzoic Acid; D003773:Dental Plaque; D016966:Porphyromonas gingivalis / Q000378:metabolism; D013298:Streptococcus sanguis
chemical_list: D010129:4-Aminobenzoic Acid