Amyloid deposition in ocular tissues of patients with familial amyloidotic polyneuropathy (FAP).
It is known that the severity of ocular symptoms does not always correlate with the systemic symptoms in patients with familial amyloidotic polyneuropathy (FAP ATTR V30M). The ocular tissues may have their own TTR metabolic system. The aim of this study is to clarify the distribution of amyloid deposition in the ocular tissues and to investigate the relationship between ocular symptoms and histopathological changes. We analyzed histopathologically 9 autopsied eyes taken from 3 Japanese and 6 Swedish patients with FAP ATTR V30M. Localization of amyloid deposition varied among the different cases, but there were some tendencies in the distribution. The degree of amyloid deposition in the ocular tissues was not always correlated with the duration of the disease. The frequency of amyloid deposition in the conjunctiva, iris, trabecular meshwork and vitreous body were 88.9%, 44.4%, 11.1% and 11.1% respectively in the 9 patients. These frequencies in the histopathological changes correlated with the frequencies in the clinical ocular manifestations as previously reported.
Haraoka
Katsuki
K
First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Ando
Yukio
Y
Ando
Eiko
E
Sandgren
Ole
O
Hirata
Akira
A
Nakamura
Masaaki
M
Terazaki
Hisayasu
H
Tajiri
Takahiro
T
Tanoue
Yutaka
Y
Sun
Xuguo
X
Okabe
Hiroaki
H
Tanihara
Hidenobu
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000378:metabolism*; D028227:Amyloid Neuropathies, Familial / Q000378:metabolism* / Q000473:pathology; D003224:Congo Red; D005123:Eye / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000682:Amyloid; D003224:Congo Red