Kinetics of carboxy-terminal propeptide of type I procollagen in pediatric patients undergoing peritoneal dialysis.
Carboxy-terminal propeptide of type I procollagen (PICP) is used as a marker of bone formation and, presumably, also peritoneal fibrosis. The aim of the present study was to assess the effect of dialysate PICP level (PICPd) on serum PICP level (PICPs). The study group consisted of 20 patients divided into two groups: group A consisted of 10 children without peritonitis, mean age 13.6 +/- 5 years, 3 on continuous ambulatory peritoneal dialysis (CAPD) and 7 on automated peritoneal dialysis (APD); and group B consisted of 10 children with peritonitis (last episode having occurred at least 2 months before the study), mean age 13.9 +/- 2 years, 8 on CAPD and 2 on APD. Osmolarity of the dialysate fluid in groups A and B was similar (375.7 +/- 42 mOsm/L and 363.1 +/- 16 mOsm/L respectively). The PICPs and PICPd levels, PICP index (PICPd/PICPs), PICP peritoneal clearance (ClPICP), and PICP mass transfer (MTPICP) were measured in both groups. Mean PICPs was higher in group B, but the difference was not significant. No significant differences were seen in the mean values of PICPd, PICP index, ClPICP, and MTPICP between groups. Levels of PICPd correlated positively with ClPICP (r = 0.75, p < 0.001) and negatively with MTPICP (r = -0.89, p < 0.0001). No associations were seen between PICPs and PICPd, ClPICP, and MTPICP. No associations were observed between osmolarity and ClPICP and MTPICP. Serum PICP level in children undergoing peritoneal dialysis does not depend on peritoneal PICP level.
Leszczynska
Beata
B
Department of Pediatric Nephrology, Medical University of Warsaw, Warsaw, Poland.
Roszkowska-Blaim
Maria
M
D000293:Adolescent; D000328:Adult; D002648:Child; D015314:Dialysis Solutions / Q000737:chemistry; D006801:Humans; D009994:Osmolar Concentration; D010446:Peptide Fragments / Q000493:pharmacokinetics*; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011347:Procollagen / Q000493:pharmacokinetics*
D015314:Dialysis Solutions; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide