Membrane-permeant derivatives of mannose-1-phosphate.
For treatment of congenital disorder of glycosylation type Ia (CDG-Ia) membrane-permeant derivatives of mannose-1-phosphate are required. Employing biologically cleavable phosphate protecting groups advantageous precursor derivatives could be synthesized following a facile approach. Their enzymatic cleavages using esterase from porcine liver (E.C. 3.1.1.1) were investigated.
Rutschow
Synke
S
Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, Hamburg, Germany.
Thiem
Joachim
J
Kranz
Christian
C
Marquardt
Thorsten
T
D000818:Animals; D001692:Biological Transport; D002463:Cell Membrane Permeability; D018981:Congenital Disorders of Glycosylation / Q000188:drug therapy; D004950:Esterases / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008360:Mannosephosphates / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship; D013552:Swine
D008360:Mannosephosphates; C027693:mannose-6-phosphate; D004950:Esterases