title: [A case of migratory air space infiltration after radiation therapy for breast cancer].
abstract: A 54-year-old woman underwent conserving surgery for right breast cancer, and received a cumulative dose of 50 Gy of radiation therapy to the remaining part of the right breast. About five months after the termination of irradiation, cough and low-grade fever developed. The chest radiograph showed an infiltrative shadow in the right lung field. Organizing pneumonia was identified in the transbronchial lung biopsy specimen. After prednisolone was given to the patient the clinical symptoms and infiltrates seen in the radiograph disappeared. In the course of tapering the prednisolone dose, new infiltrative shadows developed in the upper right lung and the left lung. The histologic changes were shown by transbronchial lung biopsy to be organizing pneumonia. The increased dose of prednisolone resulted in the rapid improvement of the clinical symptoms and chest radiograph abnormalities. This case suggests that breast radiation after conserving surgery for breast cancer may cause a pathologic process similar to that of bronchiolitis obliterans organizing pneumonia.
authors.affiliation: Department of Respiratory Medicine, Yaizu Municipal Hospital, 1000 Doubara, Yaizu, Shizuoka, 425-0055, Japan.
authors.forename: Fujisawa
authors.initials: F
authors.lastname: Tomoyuki
authors.forename: Hatakeyama
authors.initials: H
authors.lastname: Shinobu
authors.forename: Tachibana
authors.initials: T
authors.lastname: Akio
authors.forename: Suzuki
authors.initials: S
authors.lastname: Kazue
authors.forename: Oka
authors.initials: O
authors.lastname: Teruaki
authors.forename: Suda
authors.initials: S
authors.lastname: Takahumi
authors.forename: Chida
authors.initials: C
authors.lastname: Kingo
authors.forename: Nakamura
authors.initials: N
authors.lastname: Hirotoshi
mesh_terms: D000388:Air; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D018549:Cryptogenic Organizing Pneumonia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D013902:Radiography, Thoracic; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone