A flexible strategy for the divergent modification of pleuromutilin.
The complex antibacterial natural product, pleuromutilin, can be directly modified by the radical addition reaction of various xanthates to the unactivated terminal olefin present on C-12.
Bacqué
Eric
E
Aventis, Centre de Recherche de Romainville, 102 Route de Noisy, F-93235 Romainville, France.
Pautrat
François
F
Zard
Samir Z
SZ
D000577:Amides; D000900:Anti-Bacterial Agents / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry*; D015195:Drug Design; D004952:Esters; D011083:Polycyclic Compounds; D000097567:Pleuromutilins
D000577:Amides; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D004952:Esters; D011083:Polycyclic Compounds; D000097567:Pleuromutilins