[Fibrin-collagen substance as a vehicle for local application of antibacterial agents].
Inhibitory activity of fibrin-collagen substance (FCS) impregnated by various antibacterial agents against various microorganisms was investigated. It was demonstrated that antibacterials bind well with FCS, providing its sufficient antibacterial activity. Determination of growth-inhibition zones showed that antibacterial agents diffuse into medium well and demonstrated the same activity as discs with antibiotics. For clinical practice it is recommended to use for impregnation the following drugs: gentamycin, meropenem, cefriaxone and ciprofloxacin.
Gorskiĭ
V A
VA
Russian State Medical University, Municipal Clinical Hospital No. 55, Moscow.
Gertsog
A A
AA
Leonenko
I V
IV
Shamanek
T P
TP
Sokov
B N
BN
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003094:Collagen; D015169:Colony Count, Microbial; D004337:Drug Carriers; D016983:Enterococcus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005337:Fibrin; D041121:Klebsiella oxytoca / Q000187:drug effects; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D005337:Fibrin; D003094:Collagen