title: Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain.
abstract: We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.
authors.affiliation: Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.forename: Chigusa
authors.initials: C
authors.lastname: Shimizu-Okabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Akihito
authors.initials: A
authors.lastname: Okabe
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: Tsuguhiro
authors.initials: T
authors.lastname: Ogawa
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
authors.forename: Atsuo
authors.initials: A
authors.lastname: Fukuda
authors.forename: Kohji
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology*; D002712:Chlorides / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D028021:Sodium-Potassium-Chloride Symporters / Q000096:biosynthesis*; D064506:Solute Carrier Family 12, Member 2; D027981:Symporters / Q000096:biosynthesis*; D000096922:K Cl- Cotransporters
chemical_list: D002712:Chlorides; D015347:RNA Probes; D012333:RNA, Messenger; D028021:Sodium-Potassium-Chloride Symporters; D064506:Solute Carrier Family 12, Member 2; D027981:Symporters; D000096922:K Cl- Cotransporters; C578879:Slc12a2 protein, rat