[Benign metastasizing pulmonary leiomyoma: description of a case and review of the literature].
We report the case of a 48-year-old woman with multiple benign metastasizing leiomyomas in both lungs and a single retroperitoneal leiomyoma. The patient underwent surgical resection of the lesions 15 years after total hysterectomy for uterine myomas. Immunohistochemical studies performed on the retroperitoneal and pulmonary neoplasms showed them to be of mesenchymal derivation with smooth muscle differentiation; the samples were negative for HMB-45. Some histogenetic hypotheses for the multiple leiomyomas are presented.
Sentinelli
S
S
U.O. Anatomia Patologica e Citodiagnostica, Polo Oncologico Regina Elena, Via Elio Chianesi 53, I-00144 Roma, Italia.
Covello
R
R
Benevolo
M
M
Licci
S
S
Perrone Donnorso
R
R
D000951:Antigens, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery; D018231:Leiomyomatosis / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D058950:Melanoma-Specific Antigens; D008648:Mesoderm / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D012186:Retroperitoneal Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins