Therapeutic and biological importance of getting nucleotides out of cells: a case for the ABC transporters, MRP4 and 5.
The energy dependent transport of drugs contributes to cellular resistance and is undoubtedly a prime suspect in chemotherapeutic failure of a variety of disease processes. Early studies focused on a single gene, the multidrug resistance gene, MDR1, as a main contributor to chemotherapeutic failure. However, the multifaceted nature of cellular resistance lead to the discovery of the MRP gene. This pivotal finding and the concurrent rapid development of gene databases lead to the expansion of the MRP gene family. The purpose of this review is to discuss two of the recently described MRP family members that were orphans until their role in drug resistance was discovered. This review will provide an overview of the current state of our understanding of MRP4 and 5.
Adachi
Masashi
M
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 332 N Lauderdale Avenue, Memphis, TN 38105, USA.
Reid
Glen
G
Schuetz
John D
JD
D000818:Animals; D001692:Biological Transport / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D004358:Drug Therapy; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis* / Q000235:genetics; D009712:Nucleotides, Cyclic / Q000378:metabolism
D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009712:Nucleotides, Cyclic; C073492:ABCC4 protein, human; C120809:ABCC5 protein, human