[Mechanisms of arterial hypertension, transplantation and renal therapies].
Considerable evidence exists indicating that pressure-volume regulation, based on the pressure-natriuresis/diuresis phenomena, is of fundamental importance in maintaining long-term arterial pressure--a theory evolved by A. C. Guyton and his co-workers during the four last decades. In all forms of hypertension studied so far, the pressure natriuresis is abnormal. The present article focuses on selected, well-documented examples illustrating how experimental and clinical impairment of renal structure and its blood supply contributed to our understanding of the aetiology and pathogenesis of hypertension. Partial nephrectomy, transplantation, renal hypoperfusion and hypersecretion of natrium-retaining hormones represent the major topics discussed in the article.
Veselý
J
J
Ustav patologické fyziologie LF UP, Olomouc. vesely@tunw.upol.cz
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004231:Diuresis / Q000502:physiology; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000503:physiopathology; D016030:Kidney Transplantation / Q000009:adverse effects; D009318:Natriuresis / Q000502:physiology