Expression of stanniocalcin-1 in megakaryocytes and platelets.
Stanniocalcin-1 (STC) is a 56-kDa homodimeric glycoprotein hormone originally found in fish, in which it regulates calcium/phosphate homeostasis and protects against toxic hypercalcaemia. The recently characterized human STC is 80% similar to fish STC. We have earlier reported a high expression of STC in terminally differentiated human and rodent brain neurones, and found that STC contributes to the maintenance of their integrity. Here, we report that mature megakaryocytes and platelets display high STC content. K562 cells, induced to megakaryocytoid differentiation in vitro, acquired expression of STC, which was not seen in untreated K562 cells or cells induced to erythroid differentiation.
Serlachius
Martina
M
Department of Pathology, Haartman Institute, University of Helsinki, Finland.
Alitalo
Riitta
R
Olsen
Henrik S
HS
Andersson
Leif C
LC
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D015152:Blotting, Northern / Q000379:methods; D015153:Blotting, Western / Q000379:methods; D002454:Cell Differentiation; D006023:Glycoproteins / Q000032:analysis* / Q000378:metabolism; D006410:Hematopoiesis; D006728:Hormones / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D020014:K562 Cells; D008533:Megakaryocytes / Q000378:metabolism*; D051379:Mice; D018613:Microscopy, Confocal / Q000379:methods; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D051381:Rats
D006023:Glycoproteins; D006728:Hormones; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C051795:teleocalcin