Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.
We report the synthesis and arraying of 29 400 structurally diverse and complex polycyclic carbocycles using diversity-oriented synthesis (DOS) and the "one bead-one stock solution" technology platform. Skeletal diversity, a difficult challenge in DOS, was achieved with a branching reaction pathway using one or two Diels-Alder reactions. This pathway yields small molecules having 10 different skeletons.
Kwon
Ohyun
O
Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Park
Seung Bum
SB
Schreiber
Stuart L
SL
D000447:Aldehydes / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D012996:Solutions; D013237:Stereoisomerism
D000447:Aldehydes; D011083:Polycyclic Compounds; D012996:Solutions