Disruption of the proprioceptive mapping in the medial wall of parkinsonian monkeys.
Parkinsonian patients present an impairment of proprioceptor-guided movement that could imply abnormal processing in the frontal mesial cortex. To test this hypothesis, we compared neuronal response to joint displacement in the supplementary and presupplementary motor areas of two monkeys, before and after the progressive establishment of an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian syndrome. After MPTP administration, neurons were activated by the passive movement of numerous joints in various directions and no longer simply by one or two joints in one direction. This impairment of the focused selection of proprioceptive inputs, imputable to dopamine depletion, could impede motor planning and thus contribute to akinesia.
Escola
Ludovic
L
Laboratoire de Neurophysiologie, Unité Mixte de Recherche Centre National de Recherche Scientifique, 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux, France.
Michelet
Thomas
T
Douillard
Gaelle
G
Guehl
Dominique
D
Bioulac
Bernard
B
Burbaud
Pierre
P
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001931:Brain Mapping; D015259:Dopamine Agents; D004594:Electrophysiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007596:Joints / Q000503:physiopathology; D008253:Macaca mulatta; D009038:Motion; D009044:Motor Cortex / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000503:physiopathology*; D011434:Proprioception / Q000502:physiology*
D015259:Dopamine Agents; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine