title: Localization of cytokines in tendinocytes of the superficial digital flexor tendon in the horse.
abstract: Although inflammatory activation of cytokines have been analyzed in various tissues, there have only been a few and as-yet-inconclusive studies on cytokines in equine tendons. In this study, the localizations of 4 cytokines (IL-1alpha, IL-1beta, TNFalpha and IFNgamma) in tendinocytes of the equine superficial digital flexor tendon (SDFT) were analyzed by the use of an immunohistochemical method. In inflamed tendons positive staining for all 4 cytokines antibodies were detected in endotedinieum cells and vascular epithelial cells. In contrast, negative or trace immunoreactions were obtained in many tendinocytes in the normal tendon. The variation in cellular immune responses depending on the kind of cytokine may reflect the physiological/pathological condition of the SDFT.
authors.affiliation: Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Hosaka
authors.forename: Rikio
authors.initials: R
authors.lastname: Kirisawa
authors.forename: Etsuko
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ueda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwai
authors.forename: Kazushige
authors.initials: K
authors.lastname: Takehana
mesh_terms: D000818:Animals; D016207:Cytokines / Q000032:analysis* / Q000276:immunology; D006734:Horse Diseases / Q000276:immunology* / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D052256:Tendinopathy / Q000276:immunology* / Q000473:pathology / Q000662:veterinary*; D013710:Tendons / Q000166:cytology* / Q000276:immunology* / Q000473:pathology
chemical_list: D016207:Cytokines