title: Effects of FK317, a novel anti-cancer agent, on survival of mice bearing B16BL6 melanoma and Lewis lung carcinoma.
abstract: The effects of FK317 (11-acetyl-8-carbamoyloxymethyl-4-formyl-6-methoxy-14- oxa-1,11-diazatraacylo[7.4.1.0(2.7).0(10.2)]-tetradeca-2,4,6-trien-9-yl acetate), a novel anti-cancer agent, and mitomycin C (MMC) on survival time of mice bearing B16BL6 melanoma and Lewis lung carcinoma (LLC), induced by intravenous inoculation of the tumor, were investigated. Treatment with FK317 resulted in a significant prolongation of survival time in both tumor models. Four of ten mice bearing B16BL6 were disease-free following FK317 treatment. In contrast, MMC was not effective in prolonging survival time. Overall, this study demonstrated that FK317 shows more potent survival extension in mice bearing B16BL6 and LLC than MMC, suggesting that FK317 may have therapeutic utility for cancer chemotherapy.
authors.affiliation: Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Inami
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kawamura
authors.forename: Susumu
authors.initials: S
authors.lastname: Tsujimoto
authors.forename: Fusako
authors.initials: F
authors.lastname: Nishigaki
authors.forename: Sanae
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Naoe
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sasakawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Matsuo
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Manda
authors.forename: Toshio
authors.initials: T
authors.lastname: Goto
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D016685:Mitomycin / Q000627:therapeutic use; D010078:Oxazines / Q000627:therapeutic use*; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D010078:Oxazines; D016685:Mitomycin; C112463:FK 317 dihydrobenzoxazine