Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.
Vourloumis
Dionisios
D
Department of Medicinal Chemistry, Anadys Pharmaceuticals, Inc., San Diego, CA 92121, USA. dvourloumis@anadyspharma.com
Takahashi
Masayuki
M
Winters
Geoffrey C
GC
Simonsen
Klaus B
KB
Ayida
Benjamin K
BK
Barluenga
Sofia
S
Qamar
Seema
S
Shandrick
Sarah
S
Zhao
Qiang
Q
Hermann
Thomas
T
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D006595:Hexosamines / Q000737:chemistry* / Q000494:pharmacology*; D008156:Luciferases / Q000235:genetics; D008958:Models, Molecular; D014176:Protein Biosynthesis / Q000187:drug effects; D012335:RNA, Ribosomal / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006595:Hexosamines; D012335:RNA, Ribosomal; D008156:Luciferases