title: [The efficacy of prophylactic administration of SBT/ABPC for postoperative infection in neurosurgical operations].
abstract: We investigated prospectively the efficacy of sulbactam sodium/ampicillin sodium (SBT/ABPC), which is a combination drug of ampicillin and beta-lactamase inhibitor, as a preventive drug against postoperative infection in the field of neurological surgery. One hundred and six patients were given SBT/ABPC as follows: Before anesthetic induction at surgery, 1.5 g of SBT/ABPC was administrated by intravenous drip infusion, and further doses were continued at 12-hour intervals for 5 to 7 days. We assessed postoperative infection, type of surgery, duration of operation, and amount of hemorrhage. Search for related side effects and bacteriological examinations of the nasal cavity and throat before and after treatment were performed. The result was that postoperative infection was found in none of the patients. Adverse reactions due to SBT/ABPC such as apparent skin symptoms or gastrointestinal symptoms were not observed. Considering infections highly resistant to MRSA, SBT/ABPC would be effective to prevent postoperative infection in neurosurgical operations and could be used safely.
authors.affiliation: Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto-city, Nagano 390-8621, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Idomari
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sakai
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Takasawa
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Miyairi
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yako
authors.forename: Takahiro
authors.initials: T
authors.lastname: Murata
authors.forename: Michio
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Junpei
authors.initials: J
authors.lastname: Nitta
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hongo
authors.forename: Sigeaki
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Toshiki
authors.initials: T
authors.lastname: Aoki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001932:Brain Neoplasms / Q000601:surgery; D002561:Cerebrovascular Disorders / Q000601:surgery; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011446:Prospective Studies; D013407:Sulbactam / Q000627:therapeutic use*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000667:Ampicillin; D013407:Sulbactam