Chemical modification of a viral cage for multivalent presentation.
Here we present generalized methods for chemically modifying the surface of a viral protein cage; this exploits the chemistry of native and engineered surface exposed functional groups for multivalent presentation of ligands.
Gillitzer
Eric
E
119 ABS, Montana State University, Bozeman, MT 59715, USA.
Willits
Debbie
D
Young
Mark
M
Douglas
Trevor
T
D017795:Bromovirus / Q000737:chemistry; D003460:Crystallization; D005456:Fluorescent Dyes; D008024:Ligands; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D015202:Protein Engineering / Q000379:methods*; D013499:Surface Properties; D014764:Viral Proteins / Q000737:chemistry*
D005456:Fluorescent Dyes; D008024:Ligands; D010455:Peptides; D014764:Viral Proteins