Type IV secretion and Brucella virulence.
The type IV secretion system, encoded by the virB region, is a key virulence factor for Brucella. The 12 genes of the region form an operon that is specifically induced by phagosome acidification in cells after phagocytosis. We speculate that the system serves to secrete unknown effector molecules, which allow Brucella to pervert the host cell endosomal pathways and to create a novel intracellular compartment in which it can replicate.
Boschiroli
Maria Laura
ML
INSERM U431, Faculté de Médecine, Avenue Kennedy, 30900 Nîmes, France.
Ouahrani-Bettache
Safia
S
Foulongne
Vincent
V
Michaux-Charachon
Sylvie
S
Bourg
Gisele
G
Allardet-Servent
Annick
A
Cazevieille
Chantal
C
Lavigne
Jean-Phillipe
JP
Liautard
Jean Pierre
JP
Ramuz
Michel
M
O'Callaghan
David
D
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D002002:Brucella / Q000235:genetics* / Q000472:pathogenicity*; D004268:DNA-Binding Proteins / Q000235:genetics; D011992:Endosomes / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D009876:Operon; D014774:Virulence; D037521:Virulence Factors
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D037521:Virulence Factors