title: [A molecular epidemiological study of childhood lead poisoning in lead-polluted environment].
abstract: OBJECTIVE
  The relationship between polymorphisms of ALAD and VDR genes and individual susceptibility of lead poisoning was investigated in children highly-exposed to lead.
  
  
  METHODS
  Four hundred and sixty-nine children were recruited into this study and the blood lead, ZPP, hemoglobin as well as three physical developmental indexes (head circumference, height and weight) were measured. VDR and ALAD gene polymorphisms were analyzed by the methods of PCR-RFLP.
  
  
  RESULTS
  The subjects with ALAD2 allele had higher ZPP level (10.12 micro mol/L vs 12.87 micro mol/L) (P = 0.017). The subjects with B allele has larger head circumference than only with b allele (51.19 cm vs 50.75 cm) (P = 0.028).
  
  
  CONCLUSIONS
  It was suggested that the ALAD gene polymorphism modified the relationship between blood lead and ZPP and the VDR gene variants influenced the skull development in children living under lead-polluted environment. The polymorphism of ALAD and VDR genes might serve as the molecular inherited factors modifying the susceptibility of lead poisoning.
authors.affiliation: Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zheng
authors.forename: Shuguang
authors.initials: S
authors.lastname: Leng
authors.forename: Wenjia
authors.initials: W
authors.lastname: Song
authors.forename: Yawen
authors.initials: Y
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Niu
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Zhang
authors.forename: Huifang
authors.initials: H
authors.lastname: Yan
authors.forename: Yuying
authors.initials: Y
authors.lastname: Liu
authors.forename: Qingxiao
authors.initials: Q
authors.lastname: Huang
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000483:Alleles; D001827:Body Height / Q000187:drug effects / Q000235:genetics; D001835:Body Weight / Q000187:drug effects / Q000235:genetics; D002648:Child; D002681:China / Q000453:epidemiology; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D007855:Lead Poisoning / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D000623:Porphobilinogen Synthase / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol; D007854:Lead; D000623:Porphobilinogen Synthase