Silicon tether-aided coupling metathesis: application to the synthesis of attenol A.
A new synthesis of attenol A is described. Key features of this work include a crucial silicon tether-aided coupling metathesis step and the use of iodoetherification as an efficient protection method for 1,5-ene-ols. [reaction: see text]
Van de Weghe
Pierre
P
Laboratoire de Chimie Organique et Bioorganique associé au CNRS, Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, 3 Rue Alfred Werner, F-68093 Mulhouse Cedex, France. p.vandeweghe@uha.fr
Aoun
Darina
D
Boiteau
Jean-Guy
JG
Eustache
Jacques
J
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000633:toxicity; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000633:toxicity; D015394:Molecular Structure; D012825:Silicon
D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; C423354:attenol A; D012825:Silicon