Time course of cognitive recovery after propofol anaesthesia: a level of processing approach.
The aim of this study was to investigate the time course of recovery of verbal memory after general anaesthesia, as a function of the level (shallow or deep) of processing induced at the time of encoding. Thirty-one patients anaesthetized with propofol and alfentanil were compared with 28 control patients receiving only alfentanil. Memory functions were assessed the day before and 1, 6 and 24 hr after operation. Results show that for the anaesthetized group, shallow processing was impaired for 6 hr after surgery whereas the deeper processing was not recovered even at 24 hr. In addition, no specific effect of age was found.
N'Kaoua
Bernard
B
Laboratoire de Sciences Cognitives E.A. 487, Université Victor Ségalen, Bordeaux 2, France.
Véron
Anne-Lise H
AL
Lespinet
Véronique C
VC
Claverie
Bernard
B
Sztark
François
F
D000328:Adult; D000368:Aged; D015760:Alfentanil / Q000009:adverse effects; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects*; D005260:Female; D006801:Humans; D008096:Lithotripsy; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D013647:Task Performance and Analysis; D013997:Time Factors; D018666:Ureteroscopy
D018686:Anesthetics, Intravenous; D015760:Alfentanil; D015742:Propofol