[The hyperplasia-adenoma sequence: a case supporting this hypothesis].
We described the morphological, histochemical and immunohistochemical findings of a polyp detected in the left colon (splenic flexure) in which the diagnosis was atypical hyperplastic polyp. The description is focused on the capability of a hyperplastic polyp to evolve into adenomatous tissue through different modalities.
Villanacci
V
V
2o Servizio di Anatomia ed Istologia Patologica, Università degli Studi di Brescia, Spedali Civili di Brescia, P.le Spedali Civili 1 I-25100 Brescia, Italia. villan@iol.it
Zambelli
C
C
Santoro
A
A
Nascimbeni
R
R
Ghirardi
M
M
Salerni
B
B
D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D003106:Colon / Q000378:metabolism / Q000473:pathology*; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology*; D003111:Colonic Polyps / Q000737:chemistry / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D006965:Hyperplasia; D007381:Intermediate Filament Proteins / Q000032:analysis; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D053554:Keratin-20; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; D053554:Keratin-20; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53