Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).
A crude ethanol extract and hexane fraction from Morinda citrifolia Linn. (Rubiaceae) show antitubercular activity. The major constituents of the hexane fraction are E-phytol, cycloartenol, stigmasterol, beta-sitosterol, campesta-5,7,22-trien-3beta-ol and the ketosteroids stigmasta-4-en-3-one and stigmasta-4-22-dien-3-one. E-Phytol, a mixture of the two ketosteroids, and the epidioxysterol derived from campesta-5,7,22-trien-3beta-ol all show pronounced antitubercular activity.
Saludes
Jonel P
JP
Research Center for the Natural Sciences, University of Santo Tomas, Espana, Manila 1008, Philippines.
Garson
Mary J
MJ
Franzblau
Scott G
SG
Aguinaldo
Alicia M
AM
D000995:Antitubercular Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008826:Microbial Sensitivity Tests; D032066:Morinda; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
D000995:Antitubercular Agents; D010936:Plant Extracts