Acute ventilatory and circulatory reactions evoked by nicotine: are they excitatory or depressant?
Either excitatory or inhibitory cardio-respiratory responses induced by nicotine have been reported. We evaluated the joint and separate contributions of peripheral arterial chemoreceptors and pulmonary vagal afferences to nicotine-induced cardio-respiratory responses in 11 pentobarbitone-anaesthetized cats. Nicotine, given i.v. in doses of from 1 to 200 microg/kg, evoked dose-dependent transient increases in tidal volume (VT) and arterial blood pressure (BP), but the highest doses evoked brief apnoea, immediately followed by intense hyperventilation, as well as discrete early hypotension followed by late hypertension. Bilateral section of the aortic and carotid nerves abolished all hyperventilatory responses to nicotine, giving way to apnoea followed by few cycles of reduced VT and profound hypotension followed by slight hypertension in response to intermediate doses (50-100 microg/kg). Subsequent bilateral vagotomy (BV) suppressed apnoeic and hypotensive responses. In other cats initially subjected to BV, only increases in VT and BP were observed in response to nicotine, effects which were no longer observed after additional carotid and aortic deafferentation. These data suggest that excitatory effects of nicotine on respiration and BP are reflexes evoked by stimulation of peripheral arterial chemoreceptors, while inhibitory effects are also reflex responses but evoked from stimulation of pulmonary vagal afferences.
Fernández
Ricardo
R
Laboratory of Neurobiology, Catholic University of Chile, PO Box 114-D, Santiago 1, Chile.
Larraín
Carolina
C
Zapata
Patricio
P
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002346:Carotid Sinus / Q000293:injuries; D002415:Cats; D002628:Chemoreceptor Cells / Q000502:physiology*; D003714:Denervation / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume / Q000187:drug effects; D061223:Vagus Nerve Injuries
D005731:Ganglionic Stimulants; D009538:Nicotine