Roles of mucin-type O-glycans in cell adhesion.
Mucin-type O-glycans containing Core2 branches have distinctly different functions from those O-glycans that contain Core1 structures. Core2 branched O-glycans can have terminal structures that function as ligands for carbohydrate binding proteins. However, sialylated Core2 branched O-glycans without additional modifications exhibit anti-adhesive properties. These results demonstrate that certain mucin-type O-glycans can either facilitate or attenuate cell adhesion depending on the core structures and the structures of the non-reducing termini.
Fukuda
Minoru
M
Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute, La Jolla, CA 92037, USA. minoru@burnham-inst.org
D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009077:Mucins / Q000378:metabolism*; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics / Q000378:metabolism*; D011134:Polysaccharides / Q000378:metabolism*
D009077:Mucins; D011134:Polysaccharides; D017351:N-Acetylglucosaminyltransferases