title: Trypanocidal terpenoids from Laurus nobilis L.
abstract: Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 microM, respectively.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: Nahoko
authors.initials: N
authors.lastname: Uchiyama
authors.forename: Keiji
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
authors.forename: Akiko
authors.initials: A
authors.lastname: Tsubouchi
authors.forename: Junko
authors.initials: J
authors.lastname: Nakajima-Shimada
authors.forename: Takashi
authors.initials: T
authors.lastname: Aoki
mesh_terms: D000818:Animals; D006367:HeLa Cells; D006801:Humans; D027442:Laurus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D013729:Terpenes; D014344:Trypanocidal Agents