Bridging genetics and genomics in neurology.
The Human Genome Project has stimulated a change in the ways human diseases are studied genetically. The field is moving towards a genome-wide approach to identifying susceptibility genes and to understanding the molecular basis of diseases. In this article, we review the emerging technologies and discuss results from studies that have used genomic approaches.
Cheung
Vivian G
VG
Department of Pediatrics, University of Pennsylvania, School of Medicine, 3516 Civic Center Blvd., RM 516, Abramson, Philadelphia, PA 19104, USA. vcheung@mail.med.upenn.edu
Spielman
Richard S
RS
D020732:Cytogenetic Analysis; D015870:Gene Expression; D020022:Genetic Predisposition to Disease / Q000235:genetics; D016045:Human Genome Project; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics*; D010597:Pharmacogenetics