Evaluation of successful macular hole surgery by optical coherence tomography and multifocal electroretinography.
OBJECTIVE
To evaluate successful macular hole surgery using optical coherence tomography (OCT) and multifocal electroretinography (MFERG).


METHODS
Interventional case series.


METHODS
In a prospective study, 20 eyes of 20 patients with successful surgery for stage II, III, or IV idiopathic macular hole were evaluated by best-corrected visual acuity (BCVA), ocular examination, OCT, and MFERG preoperatively and 1, 3, 6, and 12 months postoperatively. For statistical analysis, the paired t test and nonparametric methods were used, as well as the Spearman analysis.


RESULTS
Postoperatively, all 20 eyes of 20 patients had anatomic closure of the macular hole confirmed by OCT. The center of the fovea, measured by OCT from the retinal pigment epithelium to the inner retinal surface, had a mean +/- SD thickness of 116.5 +/- 30.9 microm (range, 68-175 microm) 1 year postoperatively. Best-corrected visual acuity significantly improved (preoperative mean +/- standard deviation [SD] value, 0.131 +/- 0.081 and 1 year postoperative mean +/- SD value, 0.407 +/- 0.193). Multifocal electroretinography values area 1 (0-2.8 degrees) and area 2 (2.8-9 degrees from the center of the fovea) significantly improved (preoperative mean +/- SD values 3.10 +/- 1.334 nV/deg(2) and 3.573 +/- 1.545 nV/deg(2), respectively, and 1 year postoperative +/- SD mean values, 5.53 +/- 1.208 nV/deg(2) and 4.748 +/- 1.404 nV/deg(2), respectively). The thickness of the fovea, measured by OCT, significantly correlated with the BCVA 1 year postoperatively. One year postoperative MFERG values areas 1 and 2 were not correlated with 12-month BCVA and OCT findings.


CONCLUSIONS
Twelve months postoperatively BCVA and MFERG values significantly improved in this series of eyes with successful macular hole surgery. Optical coherence tomography findings were correlated to BCVA, but MFERG values were not correlated to BCVA and OCT findings, 1 year postoperatively.
Apostolopoulos
Michael N
MN
Department of Ophthalmology, University of Athens, Athens, Greece. ancode@otenet.gr
Koutsandrea
Chryssanthi N
CN
Moschos
Michael N
MN
Alonistiotis
Dimitrios A
DA
Papaspyrou
Alexis E
AE
Mallias
John A
JA
Kyriaki
Theodora E
TE
Theodossiadis
Panagiotis G
PG
Theodossiadis
George P
GP
D000368:Aged; D004396:Coloring Agents; D004596:Electroretinography; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D007368:Interferometry; D008027:Light; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012160:Retina / Q000502:physiology; D012167:Retinal Perforations / Q000503:physiopathology / Q000601:surgery*; D013459:Sulfur Hexafluoride / Q000627:therapeutic use; D014054:Tomography; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
D004396:Coloring Agents; D007208:Indocyanine Green; D013459:Sulfur Hexafluoride