[The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance].
OBJECTIVE
To study the expression of intercellular adhesion molecules in turbinate mucosa of allergic rhinitis and its significance.


METHODS
Samples of turbinate mucosa were from 20 cases of chronic hypertrophic rhinitis, 24 cases of non provocation period allergic rhinitis and 20 cases of provocation period allergic rhinitis and their paraffin sections were studied with immunohistochemical technique staining with ICAM 1 and LFA 1 monoclone antibodies.


RESULTS
Expression of ICAM 1 and LFA 1 were higher in turbinate mucosa of provocation period allergic rhinitis than in chronic hypertrophic rhinitis and non provocation period allergic rhinitis turbinate mucosa(P < 0.01).


CONCLUSIONS
High expression of ICAM 1 and LFA 1 in turbinate mucosa of allergic rhinitis shows that the interaction of ICAM-1/LFA-1 may participate in the inflammatory reaction of allergic rhinitis and may play an important role in the pathogenesis and development of allergic rhinitis.
Song
Xieyi
X
Department of Otolaryngology, Affiliated Changzheng Hospital, Second Military Medical University, Shanghai 200003.
Xiao
Bijun
B
Ni
Canrong
C
Zhao
Shuwei
S
Ling
Shunzhang
S
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000096:biosynthesis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*
D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1