Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.
Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an enhanced response to sleep deprivation compared with wild-type control mice. These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin.
Frank
Marcos G
MG
W. M. Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA 94143, USA. mgf@phy.ucsf.edu
Stryker
Michael P
MP
Tecott
Laurence H
LH
D000818:Animals; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data; D006706:Homeostasis / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009154:Mutation / Q000502:physiology; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000172:deficiency* / Q000235:genetics; D012890:Sleep / Q000235:genetics*; D012892:Sleep Deprivation / Q000235:genetics / Q000378:metabolism
D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin