title: Differentiation-inducing effects of verticinone, an isosteroidal alkaloid isolated from the bulbus of Fritillaria ussuriensis, on human promyelocytic leukemia HL-60 cells.
abstract: The inducer of differentiation of human promyelocytic leukemia HL-60 cells is commonly accepted to have potential therapeutic importance. Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward granulocytes. Importantly, the combination of verticinone with all-trans retinoic acid (ATRA), a well-known inducer of HL-60 cells into granulocytic lineages, was more effective than either alone, suggesting its therapeutic use in minimizing the effective dose of ATRA.
authors.affiliation: Medicinal Resources Research Center of Wonkwang University, Iksan, Republic of Korea.
authors.forename: Hyun-Ock
authors.initials: HO
authors.lastname: Pae
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Byung-Min
authors.initials: BM
authors.lastname: Choi
authors.forename: Gi-Su
authors.initials: GS
authors.lastname: Oh
authors.forename: Sang-Gi
authors.initials: SG
authors.lastname: Paik
authors.forename: Sejin
authors.initials: S
authors.lastname: Jeong
authors.forename: Kee-Myoung
authors.initials: KM
authors.lastname: Hwang
authors.forename: Young-Gab
authors.initials: YG
authors.lastname: Yun
authors.forename: Hun-Taeg
authors.initials: HT
authors.lastname: Chung
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002595:Cevanes / Q000494:pharmacology*; D031410:Fritillaria / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures / Q000737:chemistry
chemical_list: D000470:Alkaloids; D002595:Cevanes; D010840:Phytosterols; D010936:Plant Extracts; C014242:verticine