Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis.
We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.
Ugdyzhekova
D S
DS
Tomsk State Pedagogical University.
Krylatov
A V
AV
Bernatskaya
N A
NA
Maslov
L N
LN
Mechoulam
R
R
Pertwee
R G
RG
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000819:agonists / Q000378:metabolism*
D002316:Cardiotonic Agents; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D013759:Dronabinol; C062018:HU 211