title: Prolymphocytic leukaemia and Hodgkin's lymphoma.
abstract: We describe a case of B-prolymphocytic leukaemia (B-PLL) who, following a long-lasting remission with fluradabine, developed a Hodgkin's lymphoma (HL) with bone marrow involvement. A 75-yr-old male was found to have a lymphocytosis [white blood cell (WBC) count = 146 x 10(9) L(-1)], small volume axillary lymphadenopathy, and hepatosplenomegaly. The majority of circulating lymphocytes had a round nucleus and prominent single nucleolus. The patient did not respond to chlorambucil and then received fludarabine, achieving a good response lasting for 5 yr, when he manifested with B symptoms and pancytopenia. A diagnosis of HL in the bone marrow was made based on histology (Reed-Sternberg cells) and immunohistochemistry (CD30+, CD15+). Epstein-Barr virus (EBV) studies were negative. The patient was treated with chemotherapy but died 6 months later from disease progression.
authors.affiliation: Department of Pathology, Verge de la Cinta Hospital, Tortosa, Spain. htvcap@tinet.fut.es
authors.forename: Tomás Alvaro
authors.initials: TA
authors.lastname: Naranjo
authors.forename: Estel la
authors.initials: El
authors.lastname: Matutes El
authors.forename: Joaquín Jaén
authors.initials: JJ
authors.lastname: Martínez
authors.forename: Llorenç
authors.initials: L
authors.lastname: Font Ferré
authors.forename: Alicia
authors.initials: A
authors.lastname: Domingo
authors.forename: Ramón Bosch
authors.initials: RB
authors.lastname: Príncep
authors.forename: Teresa Salvadó
authors.initials: TS
authors.lastname: Usach
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D008297:Male; D016609:Neoplasms, Second Primary; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents