title: Method to correct for the effects of limited spatial resolution in phase-contrast flow MRI measurements.
abstract: Phase-contrast (PC) magnetic resonance imaging (MRI) flow measurements suffer from the effect of the point spread function (PSF) due to the limited sampling of k-space. The PSF, which in this case is a sinc function, deforms the flow profile and forms a ringing pattern around the vessel. In this work, an empirical method is presented that corrects for errors due to the deformation of the flow profile. The ringing pattern is used to obtain a well-defined vessel segmentation, which after correction provides more accurate vessel radius and volume flow rate (VFR). The correction method was developed from phantom measurements at constant flow and applied on phantom measurements at moderately pulsatile flow. After correction, the error of the estimated tube radius and the VFR was less than 10% and 5%, respectively. Corresponding errors without correction overestimated the radius by 60% and the VFR by 35%. Preliminary results indicate that the method is also valid in vivo. The variation in the estimated radius and VFR for different spatial resolution decreased when the method was applied. The presented method gives a more accurate estimation of the radius and VFR in vessels of the size of a few pixels without prior knowledge about the true vessel radius.
authors.affiliation: Department of Radiation Physics, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden. k.lagerstrand@radfys.gu.se
authors.forename: K M
authors.initials: KM
authors.lastname: Lagerstrand
authors.forename: H
authors.initials: H
authors.lastname: Lehmann
authors.forename: G
authors.initials: G
authors.lastname: Starck
authors.forename: B
authors.initials: B
authors.lastname: Vikhoff-Baaz
authors.forename: S
authors.initials: S
authors.lastname: Ekholm
authors.forename: E
authors.initials: E
authors.lastname: Forssell-Aronsson
mesh_terms: D001783:Blood Flow Velocity; D005583:Fourier Analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D011673:Pulsatile Flow