title: Viable but nonculturable Salmonella species recovery and systemic infection in morphine-treated mice.
abstract: In vivo recovery and pathogenicity of Salmonella enterica serovar Oranienburg that became viable but nonculturable (VNC) in food were examined. VNC cells were completely eliminated in normal mice but caused systemic bacteremia and were subsequently lethal to morphine-treated mice. Therefore, morphine-treated mice might be a useful bioassay for VNC Salmonella species in implicated food items.
authors.affiliation: Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Asakura
authors.forename: Masahisa
authors.initials: M
authors.lastname: Watarai
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Shirahata
authors.forename: Sou-Ichi
authors.initials: S
authors.lastname: Makino
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine / Q000494:pharmacology*; D012480:Salmonella Infections / Q000382:microbiology* / Q000401:mortality; D019779:Salmonella enterica / Q000187:drug effects / Q000472:pathogenicity*
chemical_list: D009020:Morphine