Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction.
Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.
Kater
Arnon P
AP
Laboratory for Experimental Internal Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands.
Peppelenbosch
Maikel P
MP
Brandjes
Dees P M
DP
Lumbantobing
Mika
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D051550:I-kappa B Kinase; D007249:Inflammation / Q000517:prevention & control*; D015850:Interleukin-6 / Q000096:biosynthesis; D051379:Mice; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014859:Warfarin / Q000494:pharmacology*
D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D014859:Warfarin; D017346:Protein Serine-Threonine Kinases; C496564:Chuk protein, mouse; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse; C496566:Ikbke protein, mouse