title: Soluble alpha-amino acid salts in acetonitrile: practical technology for the production of some dipeptides.
abstract: Alpha-amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibitor enalapril. [reaction: see text]
authors.affiliation: Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apartado 1072, 20080 San Sebastián, Spain. qoppanic@sc.ehu.es
authors.forename: Claudio
authors.initials: C
authors.lastname: Palomo
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Palomo
authors.forename: Francisco
authors.initials: F
authors.lastname: Palomo
authors.forename: Antonia
authors.initials: A
authors.lastname: Mielgo
mesh_terms: D000097:Acetonitriles; D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000138:chemical synthesis*; D008958:Models, Molecular; D008968:Molecular Conformation; D012492:Salts
chemical_list: D000097:Acetonitriles; D000596:Amino Acids; D004151:Dipeptides; D012492:Salts; C032159:acetonitrile