title: Diagnosis and outcome of acute bacterial meningitis in early childhood.
abstract: OBJECTIVE
  To estimate frequency of acute bacterial meningitis (ABM) in early childhood in hospital admissions, to describe clinical and diagnostic features, and to analyze mortality, complications and long term sequelae.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Pediatric wards and Rehabilitation Center of KEM Hospital, Pune.
  
  
  METHODS
  Study subjects between the ages of 1 months to 5 years with ABM were recruited. Clinical details were recorded. CSF was analysed by routine biochemical methods, antigen detection tests (Latex agglutination LAT) and microbiological studies on special media. Management was as per standard protocols. Survivors were followed up long term with neurodevelopmental studies and rehabilitation programmes.
  
  
  RESULTS
  In a study period of 2 years, 54 children (1.5% of all admissions) satisfied the criteria of ABM in early childhood; 78% were below one year and 52% were under the age of six months. Chief presentation was high fever, refusal of feeds, altered sensorium and seizures. Meningeal signs were present in only 26%. CSF C-reactive protein was positive in 41%, gram stain was positive in 67% LAT in 78% and cultures grew causative organisms in 50% of the cases. The final etiological diagnosis (as per LAT and/or cultures) were Streptococcus pneumoniae 39% Hemophilus influenzae type b 26% and others in 35% The others included one case of Neisseria meningitidis and 10 who were LAT negative and culture sterile. 39% patients developed acute neurological complications during the hospital course. 31% children with ABM died in hospital or at home soon after discharge. Six were lost to follow up. Of the 31 children, available for long term follow up (1-3 years), 14 (45%) had no sequelae. The remaining had significant neurodevelopmental handicaps ranging from isolated hearing loss to severe mental retardation with multiple disabilities.
  
  
  CONCLUSIONS
  ABM in early childhood has a considerable mortality, morbidity and serious long term sequelae. Neurodevelopmental follow up and therapy should begin early. Etiological diagnosis can be enhanced by LAT and good culture media. H. influenzae b and S. pneumoniae account for more than 60% of ABM in early childhood.
authors.affiliation: Department of Pediatrics, and Microbiology, K.E.M. Hospital, Pune, India.
authors.forename: Nandita
authors.initials: N
authors.lastname: Chinchankar
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Mane
authors.forename: Sheila
authors.initials: S
authors.lastname: Bhave
authors.forename: Swatee
authors.initials: S
authors.lastname: Bapat
authors.forename: Ashish
authors.initials: A
authors.lastname: Bavdekar
authors.forename: Anand
authors.initials: A
authors.lastname: Pandit
authors.forename: K B
authors.initials: KB
authors.lastname: Niphadkar
authors.forename: Anil
authors.initials: A
authors.lastname: Dutta
authors.forename: Didier
authors.initials: D
authors.lastname: Leboulleux
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000382:microbiology / Q000401:mortality*