title: Synthesis of the eight enantiomerically pure diastereomers of the 12-F(2)-isoprostanes.
abstract: Syntheses of the eight enantiomerically pure diastereomers of the 12-F(2)-isoprostanes (4-11) are described. The key steps included rhodium-mediated intramolecular cyclopropanation and enzymatic resolution of the racemic diol 12.
authors.affiliation: Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA. taberf@udel.edu
authors.forename: Douglass F
authors.initials: DF
authors.lastname: Taber
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: John C
authors.initials: JC
authors.lastname: Hartnett
mesh_terms: D028421:Isoprostanes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D028421:Isoprostanes