Differentiation-inducing effects of verticinone, an isosteroidal alkaloid isolated from the bulbus of Fritillaria ussuriensis, on human promyelocytic leukemia HL-60 cells.
The inducer of differentiation of human promyelocytic leukemia HL-60 cells is commonly accepted to have potential therapeutic importance. Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward granulocytes. Importantly, the combination of verticinone with all-trans retinoic acid (ATRA), a well-known inducer of HL-60 cells into granulocytic lineages, was more effective than either alone, suggesting its therapeutic use in minimizing the effective dose of ATRA.
Pae
Hyun-Ock
HO
Medicinal Resources Research Center of Wonkwang University, Iksan, Republic of Korea.
Oh
Hyuncheol
H
Choi
Byung-Min
BM
Oh
Gi-Su
GS
Paik
Sang-Gi
SG
Jeong
Sejin
S
Hwang
Kee-Myoung
KM
Yun
Young-Gab
YG
Chung
Hun-Taeg
HT
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002595:Cevanes / Q000494:pharmacology*; D031410:Fritillaria / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures / Q000737:chemistry
D000470:Alkaloids; D002595:Cevanes; D010840:Phytosterols; D010936:Plant Extracts; C014242:verticine