L-DOPA oxidation products prevent H2O2-induced oxidative damage to cellular DNA.
Using the single-cell gel electrophoresis ("Comet") assay, we show that tyrosinase-generated L-DOPA oxidation products prevent H2O2-induced oxidative DNA damage in cultured tissue cells. We propose that these oxidation products trigger cellular processes that up-regulate the overall antioxidant status of the cell, and could be incorporated into treatments of pathological conditions associated with elevated oxidative DNA damage and other manifestations of increased oxidative stress.
Shi
Yu-ling
YL
Department of Biology, The Chinese University of Hong Kong, SAR, Hong Kong, China.
Benzie
Iris F F
IF
Buswell
John A
JA
D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007980:Levodopa / Q000378:metabolism*; D016877:Oxidants / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014407:Tumor Cells, Cultured
D016877:Oxidants; D007980:Levodopa; D006861:Hydrogen Peroxide