title: Bacterial clearance after total splenectomy and splenic autotransplantation in rats.
abstract: Wistar rats submitted to isolated total splenectomy or total splenectomy combined with splenic autotransplantation were inoculated with 99mtechnetium-labeled Escherichia coli. Measurement of isotope uptake in the organs of the mononuclear phagocytic system showed a greater bacterial bloodstream clearance in rats with splenic autotransplantation. Although uptake of bacteria in the spleen was higher in the control group, the number of bacteria remaining in the bloodstream did not differ between groups. These results indicate that splenic autotransplantation preserves the phagocytic function of the spleen.
authors.affiliation: Department of General Surgery, Rio de Janeiro State University, Rua Clovis Salgado 280/104 Recreio, 22795-230, Rio de Janeiro, RJ, Brazil. rmarques@uerj.br
authors.forename: Ruy Garcia
authors.initials: RG
authors.lastname: Marques
authors.forename: Andy
authors.initials: A
authors.lastname: Petroianu
authors.forename: Márcia Betânia Nunes
authors.initials: MB
authors.lastname: de Oliveira
authors.forename: Mário
authors.initials: M
authors.lastname: Bernardo-Filho
authors.forename: Edson Mendes
authors.initials: EM
authors.lastname: Boasquevisque
authors.forename: Margareth Crisóstomo
authors.initials: MC
authors.lastname: Portela
mesh_terms: D000818:Animals; D001770:Blood Bactericidal Activity; D004926:Escherichia coli / Q000302:isolation & purification*; D005260:Female; D008221:Lymphoid Tissue / Q000382:microbiology; D008297:Male; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000637:transplantation*; D013156:Splenectomy; D014182:Transplantation, Autologous