title: Unique presentation of pleomorphic xanthoastrocytoma as a lytic skull lesion in an eight-year-old girl.
abstract: Pleomorphic xanthoastrocytomas (PXAs) are rare primary central nervous system neoplasms of childhood and early adulthood. While PXAs are intimately associated with the leptomeninges, there has never been a description of an extradural-extracranial manifestation of PXA until now. We describe a case of PXA where the patient presented with a calvarial lesion. We also review the differential diagnoses of lytic skull lesions in addition to PXA.
authors.affiliation: Department of Neurological Surgery, Miami Children's Hospital/University of Miami School of Medicine, FL 33155, USA. babybrain@mindspring.com
authors.forename: Andrew
authors.initials: A
authors.lastname: Jea
authors.forename: John
authors.initials: J
authors.lastname: Ragheb
authors.forename: Glenn
authors.initials: G
authors.lastname: Morrison
mesh_terms: D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012888:Skull Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed