title: Synthesis of alpha-amino acid derivatives and amines via activation of simple alkyl halides by zinc in water.
abstract: A method for the synthesis of alpha-amino acid derivatives and amines is developed via a zinc-mediated conjugate addition reaction of alkyl halides to alpha-phthalimidoacrylate derivatives and nucleophilic addition to imines in the presence of NH4Cl in water. No reaction was observed in the absence of water.
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, LA, USA.
authors.forename: Taisheng
authors.initials: T
authors.lastname: Huang
authors.forename: Charlene C K
authors.initials: CC
authors.lastname: Keh
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Li
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D000596:Amino Acids / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D012996:Solutions; D015032:Zinc / Q000737:chemistry
chemical_list: D000588:Amines; D000596:Amino Acids; D006846:Hydrocarbons, Halogenated; D012996:Solutions; D015032:Zinc