A new method for evaluation of safety of antiarrhythmic drugs.
A new method for preclinical evaluation of safety of antiarrhythmic drugs is proposed. During chronic stress, class I antiarrhythmic preparations increased mortality of test animals. By contrast, class II-IV antiarrhythmic agents and antioxidants produced no significant effect on mortality of experimental mice. These data agree with published results of multicenter studies.
Balashov
V P
VP
Department of Biology, Mordvinian State University. slava@mrsu.ru
Balykova
L A
LA
Shuvalova
E N
EN
Shevorakova
T I
TI
Poderov
V N
VN
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D002986:Clinical Trials as Topic / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D051379:Mice; D015337:Multicenter Studies as Topic; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants