The plant E2F-Rb pathway and epigenetic control.
Plants and animals use the E2F-Rb pathway as a major mechanism of control in the decision to continue or stop cell division. The E2F-Rb pathway controls the G1-to-S-phase transition by the timely activation of genes involved in DNA synthesis and cell-cycle control. Recent findings reveal that the E2F-Rb pathway communicates with chromatin-remodelling factors in the control of transcription and cell-cycle progression. This article highlights the fast-moving advances in the molecular and functional characterization of plant E2F proteins, and in our understanding of how the E2F-Rb pathway is activated and repressed.
Shen
Wen-Hui
WH
Institut de Biologie Moléculaire des Plantes (IBMP), CNRS-ULP, 12 rue du Général Zimmer, 67084 Strasbourg, France. wen-hui.shen@ibmp-ulp.u-strasbg.fr
D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D018797:Cell Cycle Proteins; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D018744:DNA, Plant / Q000096:biosynthesis; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016193:G1 Phase / Q000235:genetics / Q000502:physiology; D063245:Plant Development; D010944:Plants / Q000235:genetics*; D016196:S Phase / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
D018797:Cell Cycle Proteins; D002843:Chromatin; D018744:DNA, Plant; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D014157:Transcription Factors