title: [Psychiatric complications of corticoid therapy in the elderly over 65 years of age treated for Horton disease].
abstract: OBJECTIVE
  To analyse steroid psychiatric related complications in aged (> 65 years old) with temporal arteritis (TA).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  In a cohort of 126 elderly patients with a diagnosis of TA and followed with a mean period of 64 months, clinical and biological presentations, outcome and corticoid adverse effects were recorded throughout the follow-up period.
  
  
  RESULTS
  Twenty patients (16%), (mean age: 73 +/- 7.9 years, male n = 6) exhibited corticosteroid related psychiatric complications. Symptoms appear to be dose dependent and generally begin during the first month of treatment. Psychiatric disorders were as follow: mood disturbances (n = 8), depression (n = 6), mania (n = 3), anxiety neurosis (n = 2) and dementia (n = 1). Three patients were hospitalized in psychiatric units and 2 in nursing home. Psychiatric adverse affects appears to be more frequent with prednisone than prednisolone (P < 0.05).
authors.affiliation: Service de médecine interne A, hôpital Claude-Huriez, CHRU, 59037 Lille, France. al.fauchais@caramail.com
authors.forename: A L
authors.initials: AL
authors.lastname: Fauchais
authors.forename: V
authors.initials: V
authors.lastname: Boivin
authors.forename: E
authors.initials: E
authors.lastname: Hachulla
authors.forename: U
authors.initials: U
authors.lastname: Michon-Pasturel
authors.forename: M
authors.initials: M
authors.lastname: Lambert
authors.forename: V
authors.initials: V
authors.lastname: Queyrel
authors.forename: M
authors.initials: M
authors.lastname: Hebbar
authors.forename: P Y
authors.initials: PY
authors.lastname: Hatron
authors.forename: B
authors.initials: B
authors.lastname: Devulder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000139:chemically induced; D001714:Bipolar Disorder / Q000139:chemically induced; D003027:Cluster Headache / Q000188:drug therapy*; D015331:Cohort Studies; D003863:Depression / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000009:adverse effects; D011241:Prednisone / Q000009:adverse effects; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone; D011241:Prednisone