title: A novel silver(i)-mediated DNA base pair.
abstract: We have generated a novel silver(I)-mediated unnatural DNA base pair consisting of two 2,6-bis(ethylthiomethyl)pyridine nucleobases SPy. This metallo-base pair has a remarkably high pairing stability and selectivity which rivals that of the natural base pairs dA:dT and dC:dG. UV-melting experiments revealed that the dSPy:dSPy self-pair can replace natural base pairs at multiple sites and still form stable DNA duplexes.
authors.affiliation: The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Zimmermann
authors.forename: Eric
authors.initials: E
authors.lastname: Meggers
authors.forename: Peter G
authors.initials: PG
authors.lastname: Schultz
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: C470606:2,6-bis(ethylthiomethyl)pyridine; D011725:Pyridines; D012834:Silver; D004247:DNA