Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study.
This study documents expression of dopamine (DA) receptors on leukocyte subpopulations using flow cytometric techniques to identify dopamine receptors with subtype-specific antibodies. Of the D1-like receptor family (D(1) and D(5)), only D(5) was detected, and of the D2-like receptor family (D(2), D(3) and D(4)), all dopamine receptors were detected. T-lymphocytes and monocytes had low expression of dopamine receptors, whereas neutrophils and eosinophils had moderate expression. B cells and NK cells had higher and more consistent expression. Dopamine receptors D(3) and D(5) were found in most individuals whereas D(2) and D(4) had more variable expression. D(1) was never found.
McKenna
F
F
Department of Immunology, University of Liverpool, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK.
McLaughlin
P J
PJ
Lewis
B J
BJ
Sibbring
G C
GC
Cummerson
J A
JA
Bowen-Jones
D
D
Moots
R J
RJ
D001402:B-Lymphocytes / Q000737:chemistry*; D004804:Eosinophils / Q000737:chemistry*; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000737:chemistry*; D009000:Monocytes / Q000737:chemistry*; D009504:Neutrophils / Q000737:chemistry*; D011954:Receptors, Dopamine / Q000032:analysis*; D013601:T-Lymphocytes / Q000737:chemistry*
D011954:Receptors, Dopamine