Anti-Salmonella activity of alkyl gallates.
A series of alkyl gallates (3,4,5-trihydroxybenzoates) was synthesized and tested for their antibacterial activity against Salmonella choleraesuis. Nonyl (C(9)) and octyl (C(8)) gallates were noted to be the most effective against this food-borne bacterium, each with a minimum bactericidal concentration (MBC) of 12.5 microg/mL, followed by decyl (C(10)) gallate, with a MBC of 25 microg/mL. Dodecyl (C(12)) gallate exhibited activity against S. choleraesuis, with a MBC of 50 microg/mL. Propyl (C(3)) gallate showed no activity against S. choleraesuis up to 3200 microg/mL. The length of the alkyl group is not a major contributor but plays a role in eliciting the activity to a large extent. The same series of alkyl gallates, regardless of alkyl chain length, all showed nearly the same potent scavenging activity on the 1,1-diphenyl-2-picrylhydrazyl radical, indicating that the length of the alkyl group is not associated with the activity.
Kubo
Isao
I
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, USA. ikubo@uclink4.berkeley.edu
Fujita
Ken-Ichi
K
Nihei
Ken-Ichi
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D011435:Propyl Gallate / Q000494:pharmacology; D011514:Proteus vulgaris / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects*
D000900:Anti-Bacterial Agents; C016627:octyl gallate; C008259:lauryl gallate; D005707:Gallic Acid; D011435:Propyl Gallate