title: Fragile X mental retardation protein in plasticity and disease.
abstract: Fragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome and the molecular mechanisms of learning and memory. We provide an overview of current concepts of how FMRP functions in the nervous system, with special emphasis on recent evidence that FMRP has a role in metabotropic glutamate receptor-activated protein translation and synaptic plasticity.
authors.affiliation: Department of Pathology, Medical Scientist and Neuroscience Training Program, University of Wisconsin, 600 Highland Drive, Madison, WI 53792, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Todd
authors.forename: James S
authors.initials: JS
authors.lastname: Malter
mesh_terms: D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000503:physiopathology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D016601:RNA-Binding Proteins
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human