Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats.
The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant.
Ra
Seong Min
SM
Research Institute of Sports Science, Korea University, Seoul, South Korea.
Kim
Hong
H
Jang
Mi Hyeon
MH
Shin
Min Chul
MC
Lee
Taeck Hyun
TH
Lim
Baek Vin
BV
Kim
Chang Ju
CJ
Kim
Ee Hwa
EH
Kim
Kyeong Mi
KM
Kim
Sung Soo
SS
D000818:Animals; D001973:Bromodeoxyuridine; D002455:Cell Division / Q000187:drug effects; D018891:Dentate Gyrus / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012420:Running / Q000502:physiology*; D013550:Swimming / Q000502:physiology*
D009292:Narcotic Antagonists; D009270:Naloxone; D001973:Bromodeoxyuridine