title: DNA minor groove hydration probed with 4'-alkylated thymidines.
abstract: Employing modified oligonucleotides that are 4'-alkylated site-specifically we investigated the involvement of DNA minor groove hydration on DNA duplex stability and helix conformation.
authors.affiliation: Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.
authors.forename: Ilka
authors.initials: I
authors.lastname: Detmer
authors.forename: Daniel
authors.initials: D
authors.lastname: Summerer
authors.forename: Andreas
authors.initials: A
authors.lastname: Marx
mesh_terms: D000478:Alkylation; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature; D013936:Thymidine; D014867:Water / Q000737:chemistry*
chemical_list: D015335:Molecular Probes; D009841:Oligonucleotides; D014867:Water; D004247:DNA; D013936:Thymidine