Serum bupropion levels in 2 breastfeeding mother-infant pairs.
BACKGROUND
These are the first reported data on bupropion and hydroxybupropion levels in infants whose treated mothers were breastfeeding. The information will assist physicians and parents in the risk-benefit decision-making process for bupropion treatment during breastfeeding.


METHODS
Serum samples were obtained by venipuncture from 2 mother-infant pairs. The serum was assayed for levels of bupropion and its most active metabolite, hydroxybupropion.


RESULTS
Neither infant had quantifiable serum levels of bupropion or its metabolite at steady state. Neither infant had medical problems during the time of maternal therapy.


CONCLUSIONS
We recommend obtaining and publishing additional serum level findings for breastfeeding mother-infant pairs since data for bupropion are favorable but limited.
Baab
Susan W
SW
Frances Payne Bolton School of Nursing, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Peindl
Kathleen S
KS
Piontek
Catherine M
CM
Wisner
Katherine L
KL
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D001942:Breast Feeding; D016642:Bupropion / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D019052:Depression, Postpartum / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D018570:Risk Assessment
D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion