The expression of sialyl Lewis X in canine and feline mammary gland tumors.
The expression of sialyl Lewis X (sLe(x)) in 93 canine and 15 feline mammary gland tumors (MGT) obtained by surgical resection at Veterinary Medical Center, the University of Tokyo was examined by immunohistochemistry. Their clinicopathological features and prognosis were also reviewed. Approximately 60% of MGT tissues showed sLe(x) positive expressions, while all normal mammary gland tissues were negative. However, its expression was not correlated with clinicopathological features and prognosis significantly. This study suggests that sLe(x) may be a tumor-associated antigen in canine and feline MGTs.
Nakagawa
Takayuki
T
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Uyama
Rina
R
Ohashi
Emi
E
Takahashi
Tomoko
T
Hong
Sung Hyeol
SH
Mochizuki
Manabu
M
Matsunaga
Satoru
S
Nishimura
Ryouhei
R
Sasaki
Nobuo
N
D000818:Animals; D002371:Cat Diseases / Q000378:metabolism*; D002415:Cats; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D008321:Mammary Glands, Animal / Q000378:metabolism / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000737:chemistry* / Q000473:pathology; D009844:Oligosaccharides / Q000032:analysis* / Q000096:biosynthesis; D000080506:Sialyl Lewis X Antigen
D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen