Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat.
OBJECTIVE
To evaluate whether or not administration of vitamin B(6) (vitB(6)) has preventive effects on cleft palate formation.


METHODS
On the 14, 15 day of gestation, the pregnant rats were treated with administration of vitB(6) (10 mg/kg weight im) before and simultaneously with dexamethason (DEX). Compared the palatal cleft incidence of their fetuses with those whose mother were given DEX only.


RESULTS
Treatment with administration of vitB(6) before and simultaneously with DEX, the palatal cleft incidence of subject group fetuses (32.35%) was significantly less than that given DEX only (64.52%). The proportion of the palatal cleft type was also changed significantly.


CONCLUSIONS
VitB(6) decrease both the incidence and the severity of cleft palate induced by DEX in rats, which indicates VitB(6) may have preventive effects on cleft palate formation.
Zhang
Shilei
S
Center of Cleft Palate, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Yuan
Wenhua
W
D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced; D005333:Fetus; D010159:Palate; D051381:Rats; D025101:Vitamin B 6; D014815:Vitamins
D014815:Vitamins; D025101:Vitamin B 6