Epigenetic consequences of nucleosome dynamics.
Current models for epigenetic gene silencing envision a static relationship between histone modifications and transcription. However, evidence for nucleosome mobility and replacement favors a dynamic model that may explain phenomena ranging from variegation to the neural restriction of Rett syndrome.
Ahmad
Kami
K
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
Henikoff
Steven
S
D000818:Animals; D002843:Chromatin / Q000502:physiology; D004247:DNA; D020868:Gene Silencing; D006801:Humans; D009707:Nucleosomes / Q000502:physiology*; D010641:Phenotype
D002843:Chromatin; D009707:Nucleosomes; D004247:DNA