Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats.
The ability of cisplatin to induce acute (0-24 h) and delayed (24-48 and 48-72 h) phases of kaolin ingestion (pica) was investigated in the rat. Cisplatin 3 mg/kg, i.p., induced kaolin consumption during the 0-24- (P<0.001) and 48-72-h (P<0.05) periods that was antagonised by dexamethasone 1 mg/kg, i.p., administered every 12 h alone or in combination with ondansetron 2 mg/kg, i.p., administered every 12 h (P<0.05). As a single treatment, ondansetron 2 mg/kg, i.p., administered every 12 h potentiated cisplatin-induced kaolin consumption by 41% (P<0.05) during the 0-24-h period but had no action to modify the delayed response (P>0.05). Dexamethasone 1 mg/kg, i.p., administered every 12 h and cisplatin 3 and 6 mg/kg, i.p., but not ondansetron 2 mg/kg, i.p., administered every 12 h (P>0.05) reduced food consumption and decreased rat weight. The highest dose of cisplatin 6 mg/kg, i.p., induced acute (P<0.001) but not delayed kaolin ingestion (P>0.05). The action of cisplatin to induce acute and delayed pica is complicated and may be affected by drugs that modify appetite.
Rudd
John A
JA
Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. jar@cuhk.edu.hk
Yamamoto
Kouichi
K
Yamatodani
Atsushi
A
Takeda
Noriaki
N
D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D007616:Kaolin; D008297:Male; D017294:Ondansetron / Q000627:therapeutic use*; D010842:Pica / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000932:Antiemetics; D000970:Antineoplastic Agents; D007616:Kaolin; D017294:Ondansetron; D003907:Dexamethasone; D002945:Cisplatin