Hypoplastic myelodysplastic syndrome-a clinical, morphologic, or genetic diagnosis?
We report a middle-aged female with an 11-year history of nonprogressive pancytopenia and severely hypoplastic marrow with minimal morphologic dysplasia. A diagnosis of hypoplastic myelodysplastic syndrome (MDS) was made because of the finding of a persistent clonal abnormality, del(13)(q12q14), and the subsequent demonstration of a single Auer rod-containing blast in the peripheral blood smear. The case illustrates the problems in the differentiation between aplastic anemia and hypoplastic MDS.
Wong
K F
KF
Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, SAR, Hong Kong, China. kfwong@ha.org.hk
So
C C
CC
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008533:Megakaryocytes / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology