title: Diffusion-weighted imaging in acute stroke--a tool of uncertain value?
abstract: The concept of a mismatch between the lesion volume in diffusion- and perfusion-weighted magnetic resonance imaging (MRI) indicating 'tissue at risk of infarction' is based on the assumption that tissue with diffusion slowing in diffusion-weighted MRI (DWI) or decreased values of the apparent diffusion coefficient represents irreversibly damaged tissue. Recent experimental as well as clinical studies, however, have shown that tissue with diffusion slowing may well normalize if the hypoperfusion is moderate or transient. We will interpret these findings in the light of experimental data and suggest a way for the interpretation of different time courses of lesion development in DWI within a clinical MRI protocol. MR stroke imaging delivers important information in acute stroke, particularly in defining the 'tissue at risk of infarction'.
authors.affiliation: Department of Neuroradiology, University Hospitals of Hamburg-Eppendorf, Hamburg, Germany. fiehler@uke.uni-hamburg.de
authors.forename: Jens
authors.initials: J
authors.lastname: Fiehler
authors.forename: Jochen B
authors.initials: JB
authors.lastname: Fiebach
authors.forename: Achim
authors.initials: A
authors.lastname: Gass
authors.forename: Mathias
authors.initials: M
authors.lastname: Hoehn
authors.forename: Thomas
authors.initials: T
authors.lastname: Kucinski
authors.forename: Tobias
authors.initials: T
authors.lastname: Neumann-Haefelin
authors.forename: Peter D
authors.initials: PD
authors.lastname: Schellinger
authors.forename: Mario
authors.initials: M
authors.lastname: Siebler
authors.forename: Arno
authors.initials: A
authors.lastname: Villringer
authors.forename: Joachim
authors.initials: J
authors.lastname: Röther
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging / Q000592:standards*; D006801:Humans; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology; D013997:Time Factors; D014022:Tissue Survival