Physical and chemical limitations to preparation of beta radioactive stents by direct neutron activation.
Pure beta emitters are the sources of choice for intracoronary irradiations in restenosis prevention. In this work we reconsidered preparation of low activity 32P sources by ion-implantation of stable 31P into highly biocompatible pure titanium stents, followed by neutron activation. Gamma-spectrometrical analysis has shown that during activations with high thermal neutrons flux production of gamma-active long-lived contaminants is much beyond the dosimetrically acceptable limit, mainly due to the competing (n,p) reactions induced by the fast neutrons on isotopes of the bulk stent material, and to a lesser extent due to (n,gamma) reactions on chemical impurities. A potential applicability of this method for obtaining alternative beta radioactive stents is discussed.
Petelenz
Barbara
B
The Henryk Niewodniczański Institute of Nuclear Physics, Radzikowskiego 152, 31-342 Kraków, Poland. barbara.petelenz@ifj.edu.pl
Rajchel
Bogusław
B
Bilski
Paweł
P
Misiak
Ryszard
R
Bartyzel
Mirosław
M
Wilczek
Krzysztof
K
Alber
Dorothea
D
D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D002860:Chromium Radioisotopes; D003327:Coronary Disease / Q000517:prevention & control* / Q000628:therapy*; D005720:Gamma Rays; D007477:Ions; D009502:Neutrons; D010761:Phosphorus Radioisotopes; D013053:Spectrophotometry; D015607:Stents; D014025:Titanium
D002860:Chromium Radioisotopes; D007477:Ions; D010761:Phosphorus Radioisotopes; D014025:Titanium