title: Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa.
abstract: This report describes the isolation of two triterpenes from the stems of Tinospora crispa, namely, cycloeucalenol (1). and cycloeucalenone (2). for the first time. It was found that cycloeucalenol (1). slightly increased the right atrial force of contraction whereas it showed an initial reduction followed by sustained reduction of about 10% on the left atria of the rat in vitro. Cycloeucalenone showed slight change from the control on the right and left atrial force. These results suggest that cycloeucalenol and cycloeucalenone produced mild cardiotonic effects.
authors.affiliation: Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand. fscinpk@nontri.ku.ac.th
authors.forename: Ngampong
authors.initials: N
authors.lastname: Kongkathip
authors.forename: Prasan
authors.initials: P
authors.lastname: Dhumma-upakorn
authors.forename: Boonsong
authors.initials: B
authors.lastname: Kongkathip
authors.forename: Khanittha
authors.initials: K
authors.lastname: Chawananoraset
authors.forename: Prapasri
authors.initials: P
authors.lastname: Sangchomkaeo
authors.forename: Som
authors.initials: S
authors.lastname: Hatthakitpanichakul
mesh_terms: D000818:Animals; D006325:Heart Atria / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010840:Phytosterols / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar; D031610:Tinospora; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D010840:Phytosterols; D010936:Plant Extracts; D014315:Triterpenes; C472599:cycloeucalenone; C007198:cycloleucalenol