Murine animal models of systemic sclerosis.
Animal models of systemic connective tissue diseases have provided valuable insights into the causative mechanisms and the pathogenesis of these diseases, and have provided the means to test potentially useful therapeutic interventions. Although numerous animal models for systemic sclerosis (SSc) have been described, the most extensively studied are murine. One advantage of murine animal models is the large body of genetic information available for the mouse that is not available for other species. No animal model described to date reproduces precisely all manifestations of SSc. However, all animal models display tissue fibrotic changes similar to those present in SSc. The prudent interpretation of the results obtained from the study of animal models has provided substantial and valuable information about the pathogenesis of the human disease.
Jimenez
Sergio A
SA
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. sergio.jimenez@mail.tju.edu
Christner
Paul J
PJ
D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D009154:Mutation; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000187:drug effects / Q000473:pathology