title: Cloning and characterisation of amphibian ClC-3 and ClC-5 chloride channels.
abstract: Amphibians have provided important model systems to study transepithelial transport, acid-base balance and cell volume regulation. Several families of chloride channels and transporters are involved in these functions. The purpose of this review is to report briefly on some of the characteristics of the chloride channels so far reported in amphibian epithelia, and to focus on recently cloned members of the ClC family and their possible physiological roles. The electrophysiological characterisation, distribution, localisation and possible functions are reviewed and compared to their mammalian orthologs.
authors.affiliation: Laboratoire de Physiologie des Membranes Cellulaires, Université de Nice-Sophia Antipolis, UMR 6078/CNRS, 284 Chemin du Lazaret, BP 68, Villefranche sur Mer, France.
authors.forename: S
authors.initials: S
authors.lastname: Schmieder
authors.forename: S
authors.initials: S
authors.lastname: Lindenthal
authors.forename: J
authors.initials: J
authors.lastname: Ehrenfeld
mesh_terms: D000818:Animals; D002460:Cell Line; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics*; D004553:Electric Conductivity; D004848:Epithelium / Q000378:metabolism; D007422:Intestines / Q000737:chemistry; D007552:Isotonic Solutions; D007668:Kidney / Q000737:chemistry; D008845:Microinjections; D023421:Models, Animal; D009865:Oocytes / Q000737:chemistry; D018408:Patch-Clamp Techniques; D011893:Rana esculenta; D000077331:Ringer's Solution; D012867:Skin / Q000378:metabolism*; D012965:Sodium Chloride; D025262:Vacuolar Proton-Translocating ATPases / Q000032:analysis; D014982:Xenopus laevis
chemical_list: C097503:CLC-5 chloride channel; D018118:Chloride Channels; C115376:ClC-3 channel; D007552:Isotonic Solutions; D012965:Sodium Chloride; D000077331:Ringer's Solution; D025262:Vacuolar Proton-Translocating ATPases