Myotropic peptides in Drosophila melanogaster and the genes that encode them.
Myotropic peptides are structurally dissimilar; thus, they comprise different families. The cellular expressions of myotropins suggest they act as hormones, transmitters, and modulators of numerous biological processes. Drosophila melanogaster allatostatin (AST), FMRFamide-containing, dromyosuppressin (DMS), and drosulfakinin (DSK) peptides represent four different myotropin families. A different gene encodes each of these four myotropin families. D. melanogaster AST, FMRFamide-containing, DMS, and DSK peptides are present in neural and gut tissue, but are not all expressed in the same cells. These four families of myotropins affect spontaneous contractions of gut, heart, and/or reproductive tissue, but their effects are dissimilar in magnitude and time course. Based on their structures, genes, distributions, and activities, the synthesis and release of these D. melanogaster myotropins are likely governed by different sensory inputs and regulatory mechanisms. The differences in structures, precursors, cellular expressions, and activities are consistent with the conclusion that they do not play redundant roles in their effects on the frequency of muscle contractions. Orthologs of these D. melanogaster myotropins exist in other animal species; thus, research on the mechanisms involved in their production and processing, functions, and signaling may be widely applicable. Here, we review research on D. melanogaster AST, FMRFamide-containing, myosuppressin, and sulfakinin peptides.
Nichols
Ruthann
R
Biological Chemistry Department, University of Michigan, Ann Arbor 48109, USA. nicholsr@umich.edu
Bendena
William G
WG
Tobe
Stephen S
SS
D000818:Animals; D004331:Drosophila melanogaster / Q000502:physiology*; D019835:FMRFamide / Q000502:physiology; D007301:Insect Hormones / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D009479:Neuropeptides / Q000235:genetics / Q000502:physiology*; D009842:Oligopeptides / Q000502:physiology
D007301:Insect Hormones; D019476:Insect Proteins; D009479:Neuropeptides; D009842:Oligopeptides; C076523:allatostatin; C056936:drosulfakinin 1; C077905:neomyosuppressin; D019835:FMRFamide