title: Cardiac toxicity of local anesthetics in the intact isolated heart model: a review.
abstract: An editorial in 1979 by George Albright about sudden cardiac arrest after regional anesthesia spawned an era of intense research focusing on what local anesthetics do to the heart and how they do it. The ultimate goal of the research was to bring to the clinician long-acting local anesthetics that are less cardiotoxic than ones available before 1979, bupivacaine and etidocaine, in particular. In this article, I will review results of studies of local anesthetic cardiotoxicity using the intact mammalian heart in vitro published after the Albright editorial through 2001.
authors.affiliation: Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA. james.heavner@ttuhsc.edu
authors.forename: James E
authors.initials: JE
authors.lastname: Heavner
mesh_terms: D000577:Amides / Q000009:adverse effects* / Q000494:pharmacology; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002045:Bupivacaine / Q000009:adverse effects* / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects; D004562:Electrocardiography; D006329:Heart Conduction System / Q000187:drug effects; D066298:In Vitro Techniques; D008012:Lidocaine / Q000009:adverse effects* / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D000077212:Ropivacaine; D013237:Stereoisomerism; D013552:Swine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D015220:Calcium Channels; D015221:Potassium Channels; D000077212:Ropivacaine; D008012:Lidocaine; D002045:Bupivacaine