Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents.
The deep tissue propagation of near-infrared (NIR) light between 700-900 nm offers new opportunities for diagnostic imaging when employing sensitive detection techniques and NIR excitable fluorescent agents that target and report disease and metabolism. Herein, we highlight approaches for illuminating tissues and monitoring the re-emitted fluorescence for tomographic reconstruction, strategies for developing fluorescent dye constructs, and clinical opportunities for fluorescence-enhanced NIR optical imaging.
Sevick-Muraca
Eva M
EM
The Photon Migration Laboratory, Texas A&M University, College Station 77845-3122, USA. sevick@che.tamu.edu
Houston
Jessica P
JP
Gurfinkel
Michael
M
D000595:Amino Acid Sequence; D000818:Animals; D003287:Contrast Media; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008403:Mass Screening / Q000295:instrumentation / Q000379:methods*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D017785:Photons; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*; D014054:Tomography / Q000295:instrumentation / Q000379:methods
D003287:Contrast Media; D005456:Fluorescent Dyes; D010455:Peptides