[Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase].
Kitazume
Shinobu
S
Glyco-chain Functions Laboratory, Frontier Research System, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198.
Saido
Takaomi C
TC
Hashimoto
Yasuhiro
Y
D000544:Alzheimer Disease / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors / Q000502:physiology*; D010450:Endopeptidases; D006801:Humans; D012799:Sialyltransferases / Q000378:metabolism*; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D016564:Amyloid beta-Protein Precursor; D012799:Sialyltransferases; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase