title: Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase.
abstract: Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein. Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro.
authors.affiliation: Biomedical Research Laboratories, Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yoshida
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shimizugawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ono
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins; D000818:Animals; D001798:Blood Proteins; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000097:blood / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000139:chemically induced*; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats
chemical_list: D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins; C407088:Angptl4 protein, mouse; D001798:Blood Proteins; D004791:Enzyme Inhibitors; D036341:Intercellular Signaling Peptides and Proteins; D008074:Lipoproteins; D008071:Lipoprotein Lipase