Nuclear and chromatin lipids: metabolism in normal and gamma-irradiated rats.
The data on nuclear and chromatin lipid metabolism are reviewed. The amount of neutral lipids and phospholipids in nuclei of rat thymus, liver and neocortex neuron as well as the amount of lipids in rat thymus and liver chromatin are described. The metabolic responses of nuclear and chromatin lipids from thymus to different doses and dose rates of gamma-irradiation of rats are discussed. In most cases, the nuclear and chromatin lipid responses are distinct. Changes in nuclear and chromatin lipid metabolism in response to gamma-irradiation are suggested to connect with the signal transduction pathway and the regulation of the transcriptional and replicative chromatin activity. The influence of beta-carotene and picrotoxin on rat liver nuclear lipids and neocortex neuronal nuclear lipids, respectively, was analyzed. The possible involvement of the lipid traffic in the chromatin lipid responses to gamma-irradiation and other agents is suggested.
Kolomiytseva
I K
IK
Institute of Cell Biophysics RAS, 142290 Pushchino, Moscow, Russia.
Kulagina
T P
TP
Markevich
L N
LN
Archipov
V I
VI
Slozhenikina
L V
LV
Fialkovskaya
L A
LA
Potekhina
N I
NI
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000528:radiation effects*; D002843:Chromatin / Q000378:metabolism / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D050356:Lipid Metabolism; D008055:Lipids / Q000528:radiation effects; D051381:Rats
D002843:Chromatin; D008055:Lipids