title: Efficacy of ivermectin delivered via a controlled-release capsule against small lungworms (Protostrongylidae) in sheep.
abstract: To evaluate the efficacy of an ivermectin controlled-release capsule (CRC), which delivers 1.6 mg ivermectin per day intraruminally for 100 days to sheep weighing 40-80 kg (IVOMEC Maximizer CR Capsule for adult sheep, Merial), against small lungworms two studies with 48 naturally infected adult female Merino Landrace sheep were conducted. The sheep were allocated by restricted randomization based on bodyweight to untreated controls or received an ivermectin CRC. Eight sheep per group were necropsied 35, 70 or 105 days post-treatment. Lungworms were recovered by dissection or peptic digestion of the lungs. Baermann/Wetzel technique was used for faecal lungworm larval counts at weekly intervals. The efficacy of treatment was 100% against Dictyocaulus filaria and Protostrongylus rufescens (P < 0.05) at each necropsy day. The efficacy against Protostrongylus brevispiculum, Cystocaulus ocreatus and Neostrongylus linearis increased from 35 to 105 days after administration of the CRC and was found to be 100% (P < 0.01), 96.6% (P < 0.01) or 99% (P < 0.01), respectively, at 105 days post-treatment. The reductions of Muellerius capillaris counts varied and were 96.2% (P < 0.05) at 70 days post-treatment and 44.6% (P > 0.1) at 105 days post-treatment. Faecal lungworm larvae disappeared nearly completely from at least 3 weeks after the ivermectin CRC administration for all protostrongylid species including M. capillaris so that pasture infectivity will be subsequently significantly reduced.
authors.affiliation: Merial GmbH, Kathrinenhof Research Center, Rohrdorf, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Rehbein
authors.forename: M
authors.initials: M
authors.lastname: Visser
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002214:Capsules; D003692:Delayed-Action Preparations; D005243:Feces / Q000469:parasitology; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D007814:Larva; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D017206:Strongylida Infections / Q000188:drug therapy / Q000662:veterinary*; D013320:Strongyloidea / Q000145:classification* / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000969:Antinematodal Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D007559:Ivermectin