Stroke vs. chronic progressive cerebrovascular disease: a magnetic resonance imaging study of symptomatic outpatients.
Stroke is the main manifestation of cerebrovascular disease (CVD). Few studies report the insidious and progressive development of CVD. The aim of this study was the characterization of a CVD form without stroke in association with vascular subtypes and risk factors (VRF). From 105 CVD patients, 65 had stroke (62%), 13 of them had more than one stroke (20%), and 40 patients had a chronic progressive form (CPF) (38%). Mean evolution times up to maximum neurological deficiency were 1.57+/-0.94 and 344.25+/-210.96 days, respectively. Group results significantly associated with VRFs: hypertension (p=0.0046), hyperlipemia (p=0.0046) and atrial fibrillation (p=0.0173); with clinical manifestations: aphasia (p=0.0018), pyramidal syndrome (p=0.0000001) and small vessel disease (SVD) (p=0.0000001); and with MRI: bilateral infarctions (p=0.00009) and incomplete white matter lesions (IWMLs) (p=0.0061). Within the CPF group, dysarthria and complete infarctions were associated (p=0.00036). Most neurological disorders associated with CVD are related to CPF. The significant correlations of SVD, bilateral infarcts, IWMLs, dysarthria, several VRFs and the strong difference in evolution time up to maximum neurological deficiency values characterize CPF as a separate entity within CVD.
Domínguez
Raúl O
RO
Hospital Sirio-Libanés, Servicio de Neurología, Cátedra de Neurología Universidad de Buenos Aires, Buenos Aires, Argentina. dominguezraul@hotmail.com
Marschoff
Enrique R
ER
Serra
Jorge A
JA
Gallo
Alberto
A
Bartolomé
Eduardo L
EL
González
Silvia
S
D'Abbraccio
Graciela
G
Bagg
Eleonora
E
Vila
José
J
Famulari
Arturo L
AL
D000368:Aged; D001118:Argentina; D002561:Cerebrovascular Disorders / Q000473:pathology* / Q000523:psychology*; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000473:pathology* / Q000523:psychology*