title: Malignant pleural mesothelioma in a child: long-term survival with ICE-WAC chemotherapy regimen.
abstract: Malignant mesothelioma is a very rare tumor in childhood. Presently, treatment of this disease continues to be frustrating and prognosis remains poor. We here report a pediatric case of malignant pleural mesothelioma who gave a complete response to ICE-VAC chemotherapy regimen and achieved a long-term survival. An eight-year-old girl underwent exploratory thoracotomy and decortication because of a unilateral loculated and multicystic pleural effusion. Histopathological diagnosis was sarcomatoid pleural malignant mesothelioma. After decortication, chemotherapy with ICE (ifosfamide, carboplatin, etoposide) - VAC (vincristine, adriamycin, cyclophosphamide) combination was started. Six courses of chemotherapy resulted in complete clinical and radiological tumor response. She did not receive any further therapy and remains disease-free three years after the first remission. ICE-VAC chemotherapy combination resulted in a complete tumor response and a long-term disease-free survival for the presented case. The efficacy of this chemotherapy regimen in malignant mesothelioma needs to be documented in future trials.
authors.affiliation: Department of Pediatric Oncology, Institute of Oncology, Dokuz Eylül University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Kamer
authors.initials: K
authors.lastname: Mutafoğlu-Uysal
authors.forename: Aydanur
authors.initials: A
authors.lastname: Kargi
authors.forename: Faik
authors.initials: F
authors.lastname: Sarialioğlu
authors.forename: Nur
authors.initials: N
authors.lastname: Olgun
authors.forename: Arzu
authors.initials: A
authors.lastname: Kovanlikaya
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use*; D003609:Dactinomycin / Q000627:therapeutic use*; D005047:Etoposide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D016190:Carboplatin; D007069:Ifosfamide