A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans.
OBJECTIVE
To study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans.


METHODS
A case-control study based on 154 type 2 diabetes mellitus and 130 healthy controls was carried out in Jiangsu Province in 1997.


RESULTS
The age, family history of diabetes mellitus, hypertension history, high waist/hip ratio (WHR), high systolic blood pressure, huge fetus history, and the genotype of beta(3)-adrenergic receptor (beta(3)-AR) were the risk factors of type 2 diabetes mellitus; while occupational physical activity was protective factor of type 2 diabetes mellitus. The risk for diabetes mellitus distinctly increased while genetic factor and obesity, beta(3)-AR mutation were coexisting.


CONCLUSIONS
Type 2 diabetes mellitus is caused by the effect of both genetic and environmental factors.
Chen
Yu
Y
Department of Nutriology, Tourism and Chinese Cuisine of Yangzhou University, Yangzhou 225001, China.
Zhou
Ling
L
Xu
Yaochu
Y
Shen
Hongbing
H
Niu
Juying
J
D000368:Aged; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004777:Environment; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity; D012307:Risk Factors