Direct determination of ranitidine and famotidine by CE in serum, urine and pharmaceutical formulations.
A simple and sensitive capillary electrophoresis method using UV detection has been developed for the direct determination of ranitidine (RANT) and famotidine (FAMT) in serum, urine and pharmaceutical formulations. A buffer consisting of 60 mM phosphate buffer adjusted to pH 6.5 was found to provide a very efficient and stable electrophoretic system for the analysis of both drugs. The detection limits obtained were 0.088 microgram ml(-1) for RANT and 0.16 microgram ml(-1) for FAMT.
Pérez-Ruiz
Tomás
T
Faculty of chemistry, Department of Analytical Chemistry, University of Murcia, 30071, Murcia, Spain, tpr@fcu.um.es
Martinez-Lozano
C
C
Tomás
V
V
Bravo
E
E
Galera
R
R
D002626:Chemistry, Pharmaceutical; D019075:Electrophoresis, Capillary / Q000379:methods; D015738:Famotidine / Q000097:blood* / Q000737:chemistry / Q000652:urine*; D011899:Ranitidine / Q000097:blood* / Q000737:chemistry / Q000652:urine*
D015738:Famotidine; D011899:Ranitidine