title: Time-coherent expansion of MEG/EEG cortical sources.
abstract: In this study we estimated the spatial extent of cortical areas of time-coherent activity using the inverse problem in magneto/electroencephalography (MEEG). The model discussed here uses classical regularization tools in order to force the inverse solution to be piecewise coherent. First, the cortex was seeded by focal dipolar sources. Then, a time-coherent expansion (TCE) onto the cortical surface was performed in order to obtain surface source models composed of patches with uniform current density. Patches represent extended cortical regions with one single time course per active area. Results obtained from synthetic data show that using the TCE method is relevant even with a low signal-to-noise ratio, although the final estimation is often slightly biased. We applied the TCE method to evoked magnetic fields obtained after electrical stimulation of fingers in order to estimate the somatotopic cortical maps of the primary somatosensory cortex.
authors.affiliation: Cognitive Neuroscience and Brain Imaging Laboratory, CNRS UPR 640, Hôpital de La Salpêtrière, 47 Bd de l'Hôpital, 75651 Paris Cedex 13, France. Olivier.David@chups.jussieu.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: David
authors.forename: Line
authors.initials: L
authors.lastname: Garnero
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D004569:Electroencephalography / Q000379:methods*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008962:Models, Theoretical; D012815:Signal Processing, Computer-Assisted; D013003:Somatosensory Cortex / Q000502:physiology