Functional role of phospholipids in the nuclear events.
This review presents the structural and functional role of phospholipids in chromatin and nuclear matrix as well as the difference in composition and turnover compared to those present in the nuclear membrane. Nuclei have a very active lipid metabolism which seems to play an important role in the transduction of the signals to the genome in response to agonists acting at the plasma membrane level. The evidence on the presence of phospholipid-calcium-dependent protein kinase C (PKC) in nuclei and enzymes of phospholipids turnover is given. Protein kinase C interacts with nuclear phosphoinositol and sphingomyelin cycles products. This fact evidences about possibility that signal transduction events could also occur at the nuclear level during induction of cell proliferation, differentiation and apoptosis.
Alessenko
A V
AV
Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygin str, 4, 117977, Moscow, Russia. ales@sky.chph.ras.ru
Burlakova
E B
EB
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D010743:Phospholipids / Q000378:metabolism*; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
D010743:Phospholipids; D011493:Protein Kinase C