title: [Acute myeloid leukemia with infective endocarditis].
abstract: We present here a patient with acute myeloid leukemia (M2) who developed fatal infective endocarditis. On admission, the patient (67-year-old male) had mitral stenosis and atrial fibrillation. Complete remission was achieved after induction chemotherapy. During the course of consolidation therapy, he developed sepsis caused by coagulase-negative staphylococcus, which was successfully treated with antibiotics. Thereafter, blood culture yielded multidrug-resistant staphylococcus epidermidis. An echocardiogram revealed mitral valve regurgitation with vegetation. He was diagnosed as having infectious endocarditis. In spite of prolonged antibiotic therapy, destruction of the mitral valve progressed, and the patient underwent valve replacement therapy. He died of cardiac tamponade 5 days after the surgery.
authors.affiliation: Third Department of Internal Medicine, Gunma University, School of Medicine.
authors.forename: Noriko
authors.initials: N
authors.lastname: Doki
authors.forename: Takafumi
authors.initials: T
authors.lastname: Matsushima
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Karasawa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
mesh_terms: D000151:Acinetobacter Infections / Q000150:complications*; D000368:Aged; D002305:Cardiac Tamponade; D018432:Drug Resistance, Multiple; D004697:Endocarditis, Bacterial / Q000150:complications*; D017809:Fatal Outcome; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008943:Mitral Valve / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000209:etiology / Q000601:surgery; D011183:Postoperative Complications; D018805:Sepsis / Q000150:complications; D013203:Staphylococcal Infections / Q000150:complications*; D013212:Staphylococcus epidermidis