Effect on mood of subthalamic DBS for Parkinson's disease: a consecutive series of 24 patients.
A series of 24 consecutive PD patients were prospectively studied prior to and within 6 months postoperatively for mood, motor, and cognitive status to investigate the effects on mood of subthalamic deep brain stimulation (DBS) in PD. In six patients (25%), mood state worsened significantly, and three were transiently suicidal despite clear motor improvement. Caregivers and patients should be educated about the potential impact of this neurosurgical procedure on mood.
Berney
A
A
Department of Psychiatry, CHUV, Lausanne, Switzerland. aberne1@po-box.mcgill.ca
Vingerhoets
F
F
Perrin
A
A
Guex
P
P
Villemure
J-G
JG
Burkhard
P R
PR
Benkelfat
C
C
Ghika
J
J
D000328:Adult; D000339:Affect; D000368:Aged; D003071:Cognition; D003863:Depression / Q000209:etiology; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology / Q000628:therapy*; D011446:Prospective Studies; D011597:Psychomotor Performance; D020531:Subthalamic Nucleus / Q000502:physiology*