[Serum neopterin and beta2-microglobulin concentration as "prognostic markers" of AIDS].
The aim of the study was evaluation of serum neopterin and beta 2-microglobulin concentrations as "prognostic markers" of AIDS natural history.


METHODS
Investigations was performed in 68 patients (48 hiv-infected and 20 without hiv-infection), who were divided into 3 groups according to HIV CDC classification.


RESULTS
The highest serum concentrations of neopterin and beta 2-microglobulin were detected in patients with AIDS. In a non-symptomatic HIV-infected patients p24 Ag was absent. It was detected in patients with AIDS. Negative correlation between neopterin and beta 2-microglobulin serum concentration and CD4 count was detected in sera from all patients. Positive correlation was observed between p24 Ag, serum neopterin and beta 2-microglobulin concentration in patients with AIDS.


CONCLUSIONS
Progression of HIV infection was connected with an increase of serum neopterin and beta 2-microglobulin serum concentrations. Neopterin serum concentration seems to be a more sensitive marker of HIV infection than beta 2-microglobulin.
Halota
Waldemar
W
Klinika Chorób Zakaznych AM w Bydgoszczy.
Jaruga
Barbara
B
Pawłowska
Małgorzata
M
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000276:immunology; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D016655:HIV Core Protein p24 / Q000097:blood; D006801:Humans; D008297:Male; D019798:Neopterin / Q000097:blood*; D011379:Prognosis; D001613:beta 2-Microglobulin / Q000097:blood*
D015415:Biomarkers; D016655:HIV Core Protein p24; D001613:beta 2-Microglobulin; D019798:Neopterin