CYP2C9 allelic variants: ethnic distribution and functional significance.
Cytochrome P-450 (CYP) 2C9 CYP2C9 is a polymorphically expressed enzyme responsible for the metabolism of several clinically important drugs, some with a low therapeutic index. This review summarizes the structure-function relationship of the CYP2C9 promoter and coding regions, known polymorphisms, the functional significance of various CYP2C9 alleles in vitro and in vivo, and their population frequencies. In addition, possible molecular mechanisms underlying ethnic variability in the metabolism of CYP2C9 substrate drugs are discussed.
Xie
Hong-Guang
HG
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA. hong-guang.xie@mcmail.vanderbilt.edu
Prasad
Harish C
HC
Kim
Richard B
RB
Stein
C Michael
CM
D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D065729:Cytochrome P-450 CYP2C9; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013379:Substrate Specificity; D044465:White People / Q000235:genetics*
C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases