title: Current approaches for deciphering the molecular basis of combined anterior pituitary hormone deficiency in humans.
abstract: This review focuses on the general strategies currently used to decipher the molecular bases of combined pituitary hormone deficiency (CPHD) of genetic origin. By summarizing illustrative approaches that turned out to be successful for identifying an increasing number of genes involved in CPHD in the human, this article consider predictable obstacles specific to the investigation of these rare and heterogeneous conditions, while underlining the previously unsuspected roles of several of these genes during the development of extrapituitary structures.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (Unité 468), Hôpital Henri-Mondor, Créteil 94010, France. serge.amselem@im3.inserm.fr
authors.forename: Serge
authors.initials: S
authors.lastname: Amselem
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D004195:Disease Models, Animal; D018390:Gene Targeting; D008040:Genetic Linkage; D006801:Humans; D010900:Pituitary Diseases / Q000235:genetics* / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000502:physiology*; D010908:Pituitary Hormones, Anterior / Q000172:deficiency* / Q000235:genetics
chemical_list: D010908:Pituitary Hormones, Anterior