title: Telomeres: the molecular events driving end-to-end fusions.
abstract: Recent data indicate that loss of the protective telomeric capping function leads to active degradation of the telomeric G-strand overhang and DNA ligase IV-mediated non-homologous end joining. These molecular events may contribute to genomic instability early in tumorigenesis.
authors.affiliation: Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. abertuch@bcm.tmc.edu
authors.forename: Alison A
authors.initials: AA
authors.lastname: Bertuch
mesh_terms: D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000378:metabolism*; D016615:Telomere
chemical_list: D011088:DNA Ligases; D000072481:DNA Ligase ATP