Idiopathic myelofibrosis with prominent postsplenectomy erythroblastosis terminating in acute myeloid transformation.
Idiopathic myelofibrosis is a myeloproliferative disease with poor prognosis and without sufficient therapy. Acute leukemic transformation occurs in 15% of patients. The authors report the case of a 63 year old myelofibrotic patient treated with splenectomy. During the clinical course they observed unusually prominent and persistent erythroblastosis in the peripherial blood. After a two years long, relatively stable period the disease terminated in acute myeloid leukemia.
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1st Department of Internal Medicine, County Hospital, Zala, Hungary. zmk-l-bel@zalaszam.hu
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D000208:Acute Disease; D002471:Cell Transformation, Neoplastic; D004900:Erythroblasts / Q000473:pathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011086:Polycythemia / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000097:blood* / Q000209:etiology / Q000601:surgery; D013156:Splenectomy