Aspergillus nidulans is frequently resistant to amphotericin B.
The high failure rate of amphotericin B-based therapy in patients with Aspergillus nidulans infections may not be entirely a result of host factors as suggested previously. Innate resistance of A. nidulans to polyenes may contribute to the poor response in patients.
Kontoyiannis
D P
DP
Lewis
R E
RE
May
G S
GS
Osherov
N
N
Rinaldi
M G
MG
D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology; D001233:Aspergillus nidulans / Q000187:drug effects* / Q000302:isolation & purification; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B