The soluble tumor necrosis factor receptor I is an early predictor of local infective complications after colorectal surgery.
The clinical implications of increased cytokine levels after major surgery remain unclear. In this study, systemic concentration of a spectrum of cytokines, including interleukins IL-6, IL-8, IL-10, IL-1ra, and soluble tumor necrosis factor receptor-I (sTNF-RI) was examined in patients with and without postoperative septic complications following colorectal surgery. Although there were no significant changes in IL-1beta, TNF-alpha, and IL-8 serum levels during the observation period, there was a significant rise in IL-6, IL-1ra, and sTNF-RI concentrations in the entire group of patients between postoperative day 1 and 14. There were no differences between the group without and with local complications when IL-6, IL-1ra, and IL-10 were examined. The serum levels of sTNF-RI, IL-1ra, and IL-6 were found to be sensitive indicators of the pro- and anti-inflammatory response to the surgical trauma, but only sTNF-RI turned out to be a sensitive early marker of local septic postoperative complications in patients with colorectal carcinoma.
Slotwiński
Robert
R
Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw.
Olszewski
Waldemar L
WL
Chaber
Andrzej
A
Slodkowski
Maciej
M
Zaleska
Marzanna
M
Krasnodebski
Ireneusz W
IW
D015703:Antigens, CD / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015179:Colorectal Neoplasms / Q000601:surgery; D003107:Colorectal Surgery / Q000009:adverse effects*; D016207:Cytokines / Q000032:analysis / Q000097:blood*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D047888:Receptors, Tumor Necrosis Factor, Type I
D015703:Antigens, CD; D015415:Biomarkers; D016207:Cytokines; D016209:Interleukin-8; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D016753:Interleukin-10