Patterns of anti-HIV IgG3, IgA and p24Ag in perinatally HIV-1 infected infants.
The antibody patterns of HIV-1 IgG3, IgG and IgA and of HIV-1 p24 antigen were investigated in Thai infants born to mothers infected with HIV-1. In the 17 HIV-1 infected infants, anti-HIV antibodies were detected continuously over a period of 15-18 months and a high level of specific IgG3 subclass was observed. Anti-HIV IgA could be detected at 6 months of age whereas p24Ag was detected at 2 months. In 79 uninfected infants, maternal anti-HIV IgG gradually decreased over 9 months whilst specific IgG3 decayed rapidly during the first 6 months. Both p24Ag and anti-HIV IgA were not found in these uninfected infants. Thus, the disappearance of anti-IgG3 subclass antibodies within 6 months can predict whether infants are uninfected whereas the persistence of anti-HIV IgG and IgG3 subclass antibodies, the production of anti-HIV IgA antibody and the presence of p24Ag appear as an adjunct to the diagnosis of HIV vertical transmission. The necessary assays are relatively simple and could be performed individually.
Louisirirotchanakul
Suda
S
Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kanoksinsombat
Chinda
C
Likanonsakul
Sirirat
S
Sunthornkachit
Rujanee
R
Supanit
Issaracha
I
Wasi
Chantapong
C
D015331:Cohort Studies; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000097:blood / Q000276:immunology*; D015658:HIV Infections / Q000097:blood / Q000151:congenital*; D015528:HIV Seroprevalence; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007223:Infant; D007229:Infant Welfare; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013785:Thailand; D013997:Time Factors
D015483:HIV Antibodies; D016655:HIV Core Protein p24; D007070:Immunoglobulin A; D007074:Immunoglobulin G