title: Verification of scale sub-domains in elderly patients with dementia: a confirmatory factor-analytic approach.
abstract: OBJECTIVE
  Use of cognitive, psychiatric and behavioral domains to assess the effectiveness of a pharmacological or behavioral intervention in the treatment of neurodegenerative disorders (e.g., Alzheimer disease) aids the identification of specific types of impairment or distress in behavioral status and quality-of-life issues in this population. With confirmatory approaches to subscale development readily available, we can obtain a more precise understanding of the sub-components of a scale, potentially providing the basis for selecting behavioral and/or quality-of-life outcome measures that may be more sensitive to the effects of pharmacological or behavioral interventions.
  
  
  METHODS
  The authors illustrate the use of a confirmatory factor-analytic approach to verify scale sub-domains of the Neurobehavioral Rating Scale (NBRS) in elderly patients with dementia. With data collected from two groups of patients being treated for significant psychiatric and behavioral symptoms, authors investigated the relationships among scale items in order to test several competing models, including a general one-factor model, a first-order multifactor model, and a second-order factor model.
  
  
  RESULTS
  The first-order model, with seven factors, provided the best fit to the correlations among items in the NBRS, indicating the multidimensionality of problematic behaviors and symptoms exhibited by dementia patients.
  
  
  CONCLUSIONS
  Authors advocate the use of a confirmatory factor-analytic approach to verify scale sub-domains in other, more widely used rating scales for patients with dementia.
authors.affiliation: Department of Biostatistics, University of Pittsburgh, PA 15213, USA.
authors.forename: Kari B
authors.initials: KB
authors.lastname: Kastango
authors.forename: Yookyung
authors.initials: Y
authors.lastname: Kim
authors.forename: Mary Amanda
authors.initials: MA
authors.lastname: Dew
authors.forename: Sati
authors.initials: S
authors.lastname: Mazumdar
authors.forename: Benoit H
authors.initials: BH
authors.lastname: Mulsant
authors.forename: Jules
authors.initials: J
authors.lastname: Rosen
authors.forename: Charles F
authors.initials: CF
authors.lastname: Reynolds III
authors.forename: Paul A
authors.initials: PA
authors.lastname: Pilkonis
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Pollock
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000523:psychology; D003704:Dementia / Q000523:psychology*; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000523:psychology; D008960:Models, Psychological; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results