title: Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation.
abstract: A recent report shows that zerumbone (ZER) inhibits the proliferation of, and induces apoptosis in, colon cancer cells. We suggest a mechanism for these phenomena, based on our recently proposed redox model of cell proliferation which stresses the importance of intracellular redox potential E in the control of proliferation of normal and cancer cells.
authors.forename: A
authors.initials: A
authors.lastname: Hoffman
authors.forename: L M
authors.initials: LM
authors.lastname: Spetner
authors.forename: M
authors.initials: M
authors.lastname: Burke
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology; D005347:Fibroblasts / Q000378:metabolism; D005354:Fibrosarcoma / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D010084:Oxidation-Reduction; D010766:Phosphorylation; D008517:Phytotherapy; D011499:Protein Processing, Post-Translational; D016160:Retinoblastoma Protein / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016160:Retinoblastoma Protein; D012717:Sesquiterpenes; C403304:zerumbone; D005978:Glutathione