[Role of cytokine signaling pathways of the transforming growth factor-beta (TGF-beta) family in the regulation of hematopoiesis].
The transforming growth factor-beta (TGF-beta) family of cytokines consists of more than 30 secreted structurally related polypeptides including TGF-beta s, activins and bone morphogenetic proteins (BMP). This family regulates a broad spectrum of biological functions, including cell proliferation, differentiation, apoptosis, migration, and extracellular matrix production. Signaling by these cytokines occurs via binding to specific receptors with serine/threonine kinase activity and activation of specific downstream intracellular effectors (the receptor-regulated Smad transcription factors). TGF-beta is a regulator of all stages of hematopoiesis. Depending on the differentiation stage of the target cell, the local environment and the concentration of TGF-beta, TGF-beta can be positive or negative regulator of proliferation, apoptosis or differentiation of hematopoietic cells. TGF-beta inhibits the growth of primitive hemopoietic cells with a stem cell immunophenotype but has no effect or in some cases stimulates the growth of committed progenitors. Persistent loss of TGF-beta signaling in the hemopoietic stem cells and the primitive hemopoietic progenitor cells may possibly be involved in the development of malignant transformation.
Fuchs
O
O
Ustav hematologie a krevní transfuze, Praha. ota.fuchs@uhkt.cz
D000818:Animals; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta