Fragile X mental retardation protein in plasticity and disease.
Fragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome and the molecular mechanisms of learning and memory. We provide an overview of current concepts of how FMRP functions in the nervous system, with special emphasis on recent evidence that FMRP has a role in metabotropic glutamate receptor-activated protein translation and synaptic plasticity.
Todd
Peter K
PK
Department of Pathology, Medical Scientist and Neuroscience Training Program, University of Wisconsin, 600 Highland Drive, Madison, WI 53792, USA.
Malter
James S
JS
D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000503:physiopathology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D016601:RNA-Binding Proteins
D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human