title: Evaluation of antipyretic potential of Leucas lavandulaefolia (Labiatae) aerial part extract.
abstract: Methanol extract of Leucas lavandulaefolia (LLFE) was subjected to antipyretic evaluation with yeast-induced pyrexia in rats. A yeast suspension (10 mL/kg, s.c.) increased the rectal temperature 19 h after administration. The extract at doses of 100, 200, 400 mg/kg (i.p.) produced significant dose dependent lowering of body temperature in yeast-provoked elevation of body temperature in rats. The antipyretic effect produced was comparable to that of a standard antipyretic drug, paracetamol.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta - 700032, India.
authors.forename: Kakali
authors.initials: K
authors.lastname: Mukherjee
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
authors.forename: Pulok K
authors.initials: PK
authors.lastname: Mukherjee
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D019686:Lamiaceae; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D015003:Yeasts
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts