title: Multiple thrombotic occlusions of vessels after Russell's viper envenoming.
abstract: Systemic bleeding due to consumption coagulopathy and thrombocytopenia due to activation of procoagulants is the leading manifestation and cause of death in Russell's viper systemic envenoming. Thrombotic occlusion of the blood vessels is rare in cases of snakebite. In this report, two adult patients with Russell's viper systemic envenoming presented multiple cerebral infarctions, digital gangrenes and ischaemic organs in addition to typical clinical manifestations of bleeding diathesis and renal involvement. Our findings in these two special cases suggest that the venom-induced coagulopathy and endothelium damage, predisposed by toxin-induced vasoconstriction, might be the possible mechanism of multiple thrombotic vascular occlusions in systemic envenoming of Formosan Russell's viper.
authors.affiliation: Institute of Toxicology, National Taiwan University, Taipei, Taiwan.
authors.forename: Dong-Zong
authors.initials: DZ
authors.lastname: Hung
authors.forename: Ming-Ling
authors.initials: ML
authors.lastname: Wu
authors.forename: Jou-Fang
authors.initials: JF
authors.lastname: Deng
authors.forename: Dar-Yu
authors.initials: DY
authors.lastname: Yang
authors.forename: Shoei-Yn
authors.initials: SY
authors.lastname: Lin-Shiau
mesh_terms: D000368:Aged; D000818:Animals; D000997:Antivenins / Q000627:therapeutic use*; D005260:Female; D005734:Gangrene / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017840:Daboia; D012909:Snake Bites / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D013927:Thrombosis / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D014034:Toes / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014757:Viper Venoms / Q000506:poisoning*
chemical_list: D000997:Antivenins; D014757:Viper Venoms