title: Protective effect of anti-hypertensive treatment on cognitive function in essential hypertension: analysis of published clinical data.
abstract: Hypertension is a risk factor for stroke and may also contribute to the development of vascular cognitive impairment (VCI) and vascular dementia (VaD). Cognitive complications of hypertension and the influence of anti-hypertensive treatment were underestimated until recently. In this paper, trials investigating the effect of anti-hypertensive treatment on cognitive function were evaluated. Analysis of these studies revealed that until approximately 1990-1995 investigations have assessed primarily if anti-hypertensive treatment impaired cognitive function. Only more recent studies have investigated positive effects on cognition of anti-hypertensive medication. Drugs more extensively evaluated were diuretics, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, sartanes and Ca(2+) channel blockers. Available studies have confirmed that elevated diastolic blood pressure or pulse pressure and isolated systolic hypertension play an important role in the development of cognitive impairment. Randomized placebo-controlled trials have provided evidence that reduction of hypertension safely and effectively decreases morbidity and mortality rates and cognitive complications of hypertension. Ca(2+) channel blockers and ACE inhibitors have been shown to be effective and probably better than diuretics and beta-blockers on cognitive domains of hypertension. More extensive investigations could contribute to establishing optimal choice and drug dosage for the treatment of cognitive complications of hypertension.
authors.affiliation: Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Unità di Ricerche Cliniche, Università di Camerino, Via Scalzino, 3 62032 Camerino, Italy. francesco.amenta@unicam.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Amenta
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Mignini
authors.forename: Franco
authors.initials: F
authors.lastname: Rabbia
authors.forename: Daniele
authors.initials: D
authors.lastname: Tomassoni
authors.forename: Franco
authors.initials: F
authors.lastname: Veglio
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003072:Cognition Disorders / Q000517:prevention & control* / Q000523:psychology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000523:psychology*; D008137:Longitudinal Studies
chemical_list: D000959:Antihypertensive Agents