Primary hyperparathyroidism and the kidney: biochemical and clinical spectrum.
Primary hyperparathyroidism manifests biochemically as a disturbance in serum calcium homeostasis. The central organ setting serum calcium level is the kidney. It not only has the highest rate of active calcium transport, but the kidney also modulates serum calcium homeostasis by virtue of its endocrine role in 1,25-hydroxyvitamin D secretion. Receptors for PTH are widely expressed throughout the renal tubule and are involved in both calcium transport and endocrine function. Biochemical manifestations of primary hyperparathyroidism by the kidney include increased tubular reabsorption of calcium, decreased reabsorption of phosphate and bicarbonate, and hypercalciuria. A reduction in glomerular filtration may occur in some patients with primary hyperparathyroidism, which perturbs the diagnostic relationships among biochemical variables and induces further increases in PTH secretion. Parathyroidectomy rapidly restores the biochemical abnormalities to normal apart from chronic reduced glomerular filtration. Clinical manifestations are nephrolithiasis, which is common, and nephrocalcinosis, which is uncommon. Nephrocalcinosis may occur with or without nephrolithiasis. Risk factors for nephrolithiasis are oversaturation of urine with calcium phosphate and with calcium oxalate. Risk factors for nephrocalcinosis are not clearly defined. Parathyroidectomy greatly reduces the incidence of nephrolithiasis but has little effect on nephrocalcinosis.
Peacock
Munro
M
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.
D001639:Bicarbonates / Q000378:metabolism; D002118:Calcium / Q000378:metabolism / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000378:metabolism; D006961:Hyperparathyroidism / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000209:etiology*; D010710:Phosphates / Q000378:metabolism; D051437:Renal Insufficiency / Q000209:etiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000378:metabolism
D001639:Bicarbonates; D010710:Phosphates; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D002118:Calcium