Discussing breast cancer and hormone replacement therapy with women.
Although the results of the Women's Health Initiative showed an increased risk of breast cancer in women taking hormone replacement therapy (HRT), the absolute risk is very low. We discuss limitations of the study, questions that remain, and how to discuss the study with women at average risk and high risk for breast cancer.
Batur
Pelin
P
Department of General Internal Medicine, Gault Women's Health and Breast Pavilion, The Cleveland Clinic Foundation, Ohio 44195, USA. baturp@ccf.org
Thacker
Holly L
HL
Moore
Halle C F
HC
D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects; D015233:Models, Statistical; D010353:Patient Education as Topic; D017698:Postmenopause; D045167:Progesterone Congeners / Q000009:adverse effects; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018570:Risk Assessment
D004966:Estrogens, Conjugated (USP); D045167:Progesterone Congeners; D017258:Medroxyprogesterone Acetate