title: Recovery of psychomotor function after propofol sedation is prolonged in the elderly.
abstract: OBJECTIVE
  To assess the effects of age on recovery of psychomotor function for propofol sedation during spinal anesthesia.
  
  
  METHODS
  Propofol was continuously infused during surgery and spinal anesthesia in 15 elderly patients (65-85 yr-old) and 15 younger patients (20-50 yr-old). Infusion rates were adjusted to maintain an appropriate level of sedation using the bispectral index (range 60-70). The sedative infusion was discontinued at the end of surgery. The early recovery times from the end of propofol infusion to opening of eyes on command, sustaining a hand grip, and recall of name were noted. Psychomotor function, as measured by the Trieger's dot test, was evaluated before anesthesia and 30, 60, 90, 120 min after the end of propofol infusion.
  
  
  RESULTS
  The duration of anesthesia was 142 +/- 55 min and 134 +/- 61 min in the elderly and younger patients, respectively. No differences were observed in early recovery times between elderly and younger patients (opened their eyes on command, 6.3 +/- 4.0 min and 5.2 +/- 2.6 min; sustained a hand grip, 7.2 +/- 3.9 min and 6.1 +/- 3.5 min and recalled their name, 8.0 +/- 4.5 min and 6.5 +/- 3.8 min, P > 0.05 ). The recovery of psychomotor function in the elderly took longer compared with the younger patients, and psychomotor function in the elderly recovered at 120 min after the end of propofol infusion.
  
  
  CONCLUSIONS
  Early recovery times following propofol sedation is similar between elderly and younger patients, but recovery of psychomotor function in the elderly is delayed compared with younger patients.
authors.affiliation: First Department of Anesthesiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. mio28@mug.biglobe.ne.jp
authors.forename: Mio
authors.initials: M
authors.lastname: Shinozaki
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Usui
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Okuda
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000762:Anesthesia Recovery Period; D000775:Anesthesia, Spinal; D016292:Procedural Sedation; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D015742:Propofol; D011597:Psychomotor Performance / Q000187:drug effects*; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol