Catecholaminergic polymorphic ventricular tachycardia in a 3-year-old with occult myocarditis.
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare clinical entity in children. Occult myocarditis has not been previously implicated as an etiologic agent. A 3-year-old female presents with a presumed breath-holding spell and is found to have ventricular fibrillation requiring DC cardioversion. An invasive electrophysiological study was performed demonstrating the absence of inducible ventricular arrhythmias. Low dose epinephrine confirmed the presence CPVT. Right ventricular endomyocardial biopsies sent for polymerase chain reaction (PCR) analysis demonstrated the presence of adenoviral DNA. The authors hypothesize that occult myocarditis may be the inciting agent for CPVT in children.
Bryant
Randall M
RM
University of Florida Pediatric Cardiovascular Center, Jacksonville 32207, USA. rmbryant@ufl.edu
Redfearn
Sharon P
SP
Marangi
Don
D
Davenport
Joseph P
JP
Kuntz
Sean T
ST
Schowengerdt
Kenneth O
KO
D000258:Adenovirus Infections, Human / Q000150:complications / Q000175:diagnosis; D002675:Child, Preschool; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D004837:Epinephrine; D005260:Female; D006801:Humans; D009205:Myocarditis / Q000150:complications / Q000175:diagnosis*; D016133:Polymerase Chain Reaction; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy
D004837:Epinephrine