Immune regulation by histamine.
Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions. In addition to its well-characterised effects in the acute inflammatory and allergic responses, histamine regulates several aspects of antigen-specific immune response development. Histamine affects the maturation of dendritic cells and alters their T cell-polarising capacity. Histamine also regulates antigen-specific T helper 1 and T helper 2 cells, as well as related antibody isotype responses. Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals.
Jutel
Marek
M
Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland. marek.jutel@siaf.unizh.ch
Watanabe
Takeshi
T
Akdis
Mübeccel
M
Blaser
Kurt
K
Akdis
Cezmi A
CA
D000818:Animals; D000917:Antibody Formation / Q000276:immunology / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D006632:Histamine / Q000276:immunology / Q000502:physiology*; D007107:Immune System / Q000276:immunology / Q000502:physiology*; D051379:Mice; D009000:Monocytes / Q000276:immunology / Q000502:physiology; D011968:Receptors, Histamine / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D011968:Receptors, Histamine; D006632:Histamine