Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions.
The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-0.1g/kg) significantly inhibited passive cutaneous anaphylaxis (PCA). The mast cell number was markedly decreased at the SPT-treated PCA site. In addition, SPT decreased intracellular calcium levels of activated mast cells. These results suggest that SPT inhibit the anaphylactic degranulation of mast cells through decrease of the intracellular calcium level.
Jeong
Hyun Ja
HJ
College of Pharmacy, Wonkwang University, KI Co. Ltd., Iksan, Jeonbuk 570-749, South Korea.
Yi
Jin Mu
JM
Hong
Seung Heon
SH
Kong
Joo Young
JY
Kim
Kyung Suk
KS
Won
Jin Hee
JH
Cho
Kwang Ho
KH
Shin
Tae Yong
TY
Kim
Ha Song
HS
Kim
Hyung Min
HM
D000707:Anaphylaxis / Q000276:immunology / Q000517:prevention & control*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects; D007723:Korea; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects / Q000276:immunology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine; D002118:Calcium