title: Aplastic anemia complicating systemic lupus erythematosus--report of a case and review of the literature.
abstract: Aplastic anemia is a very unusual feature of systemic lupus erythematosus (SLE). A 32-year-old lady presented with generalized purpuric lesions and was diagnosed as having immune thrombocytopenic purpura. Fourteen months later, she developed progressive pancytopenia, arthritis of small joints, and oral ulcers. Investigations confirmed SLE with aplastic anemia. High-dose methylprednisolone therapy had been unsuccessful in controlling the pancytopenia. She had a progressive course and died due to septicemia. Even though pancytopenia is common in SLE, a bone marrow examination should be done in all cases of persistent pancytopenia to exclude bone marrow aplasia. This will help in tailoring the treatment with more aggressive immunosuppressants.
authors.affiliation: Department of Haematology, Medical College Hospital, Trivandrum-695011, India. drkpavithran@hotmail.com
authors.forename: Keechilat
authors.initials: K
authors.lastname: Pavithran
authors.forename: Navamoni Laila
authors.initials: NL
authors.lastname: Raji
authors.forename: Mathew
authors.initials: M
authors.lastname: Thomas
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000209:etiology* / Q000473:pathology; D016913:Blood Component Transfusion; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D010110:Oxymetholone / Q000627:therapeutic use; D010198:Pancytopenia / Q000209:etiology / Q000473:pathology
chemical_list: D045930:Anabolic Agents; D005938:Glucocorticoids; D010110:Oxymetholone; D008775:Methylprednisolone