title: Lipodystrophy in a cohort of human immunodeficiency virus-infected Asian patients: prevalence, associated factors, and psychological impact.
abstract: We investigated the prevalence of and factors associated with lipodystrophy in a cohort of human immunodeficiency virus (HIV)-infected patients in Singapore. A standardized questionnaire was administered to 410 consecutive patients (mainly Chinese men), and blood samples were obtained for metabolic measurements for fasting patients. Peripheral fat loss was reported by 46% of subjects, central fat gain was reported by 32%, and 8% of patients overall had a mixed clinical presentation. Levels of total cholesterol, triglycerides, glucose, and lactate were elevated in 19%, 38%, 12%, and 16% of patients, respectively. A mixture of drug-related and non-drug-related factors was associated with these changes. The body-shape changes affected the mood of 36% of patients and the work and/or social activity of 23% of patients, but only <1% of affected subjects reported a desire to stop receipt of antiretroviral therapy because of these changes. We conclude that the prevalence of and factors associated with body-shape changes and metabolic abnormalities in HIV-infected Asian patients are similar to those reported for Western cohorts, but the changes did not appear to have a major psychosocial impact on this patient population.
authors.affiliation: Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433. Paton_NIJ@ttsh.com.sg
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Paton
authors.forename: Arul
authors.initials: A
authors.lastname: Earnest
authors.forename: Yau Ming
authors.initials: YM
authors.lastname: Ng
authors.forename: Fatimah
authors.initials: F
authors.lastname: Karim
authors.forename: Jamila
authors.initials: J
authors.lastname: Aboulhab
mesh_terms: D000328:Adult; D000368:Aged; D001208:Asia / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D008060:Lipodystrophy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence