Butyric acid modulates activities of intestinal and renal disaccharidases in experimentally induced diabetic rats.
To elucidate the effect of feeding of butyric acid on disaccharidase activities, the specific activities of the disaccharidases were measured in the intestinal mucosa and kidney cortex of control and diabetic rats. Diabetes was induced in rats using streptozotocin. Rats were fed with basal diet containing wheat bran (5%) as a source of insoluble dietary fiber and guar gum (2.5%) as a source of soluble dietary fiber. The experimental group received butyric acid at 250, 500 and 750 mg/kg body weight/day. Increased activities of intestinal maltase, sucrase and lactase in diabetic rats were significantly reduced in fiber-fed diabetic group. Supplementation of butyric acid at 500 mg/kg body weight/day showed a further decrease in their activities. The activity of disaccharidases in renal tissue was decreased in diabetic rats and was significantly improved in fiber-fed diabetic group. Butyric acid feeding at 500 mg/kg body weight/day showed further improvement in their activities.
Chethankumar
Mukunda
M
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore-570 013, India.
Salimath
Paramahans Veerayya
PV
Sambaiah
Kari
K
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D020148:Butyric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D004043:Dietary Fiber / Q000008:administration & dosage; D004186:Disaccharidases / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology; D007672:Kidney Cortex / Q000201:enzymology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013213:Starch / Q000008:administration & dosage
D001786:Blood Glucose; D004043:Dietary Fiber; D020148:Butyric Acid; D013213:Starch; D004186:Disaccharidases