Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila.
Heparan sulphate proteoglycans (HSPG's) are cell surface proteins to which long, unbranched chains of modified sugars called heparan sulphate glycosaminoglycans have been covalently attached. Cell culture studies have demonstrated that HSPG's are required for optimal signal transduction by many secreted cell signaling molecules. Now, genetic studies in both Drosophila and vertebrates have illustrated that HSPG's play important roles in signal transduction in vivo and have also begun to reveal new roles for HSPG's in signaling events. In particular, HSPG's have been shown to be important in ligand sequestration of wingless, for the transport of the Hedgehog ligand, and for modulation of the Dpp morphogenetic gradient.
Nybakken
Kent
K
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115-6092, USA.
Perrimon
Norbert
N
D000581:Amidohydrolases / Q000378:metabolism; D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000196:embryology* / Q000378:metabolism / Q000502:physiology; D016220:Fibroblast Growth Factor 1 / Q000378:metabolism; D053823:Hedgehog Proteins; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D017351:N-Acetylglucosaminyltransferases / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D015238:Sulfotransferases / Q000378:metabolism; D014533:Uridine Diphosphate Glucose Dehydrogenase / Q000378:metabolism
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019812:Heparan Sulfate Proteoglycans; D017468:Receptors, Fibroblast Growth Factor; C064196:dpp protein, Drosophila; D016220:Fibroblast Growth Factor 1; C077245:hh protein, Drosophila; D014533:Uridine Diphosphate Glucose Dehydrogenase; D017351:N-Acetylglucosaminyltransferases; C090576:fng protein, Drosophila; D020794:Receptor Protein-Tyrosine Kinases; D051497:Receptor, Fibroblast Growth Factor, Type 2; D015238:Sulfotransferases; C021350:heparitin sulfotransferase; C500949:sfl protein, Drosophila; D000581:Amidohydrolases