title: Human herpesvirus 7 infection impairs the survival/differentiation of megakaryocytic cells.
abstract: In vitro infection of CD61+ megakaryocytic cells with human herpesvirus-7 (HHV-7) induced a drastic increase of apoptosis. Moreover, cells surviving HHV-7 cytotoxicity showed enhanced megakaryocytic maturation with respect to control cultures. These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis.
authors.forename: Arianna
authors.initials: A
authors.lastname: Gonelli
authors.forename: Prisco
authors.initials: P
authors.lastname: Mirandola
authors.forename: Vittorio
authors.initials: V
authors.lastname: Grill
authors.forename: Paola
authors.initials: P
authors.lastname: Secchiero
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zauli
mesh_terms: D017209:Apoptosis; D002454:Cell Differentiation; D002470:Cell Survival; D005312:Fetal Blood; D016199:Herpesvirus 7, Human / Q000502:physiology*; D006801:Humans; D008533:Megakaryocytes / Q000473:pathology / Q000821:virology*; D019349:Roseolovirus Infections / Q000473:pathology