title: Penetration of topically administered ofloxacin and trimethoprim into aqueous humor.
abstract: Ocular penetration of two topical antibiotics used to treat bacterial conjunctivitis was assessed in adult volunteers scheduled for cataract surgery. In this randomized, parallel-group study, patients instilled trimethoprim sulfate 0.1%/polymyxin B (n = 23) or ofloxacin 0.3% (n = 25) QID for 3 days, plus 4 instillations in the hour before surgery. Analysis of aqueous humor samples obtained during surgery showed a 2.4-fold greater concentration of ofloxacin over trimethoprim (1.135 micro g/ml vs 0.470 micro g/ml; P <.0001). The greater concentration of ofloxacin in ocular tissue coupled with its superior antibacterial activity profile supports its use as an alternative to trimethoprim/polymyxin B for treatment of bacterial conjunctivitis.
authors.affiliation: Cornea Research Foundation, Indianapolis, Indiana, USA. fprice@pricevisiongroup.net
authors.forename: Francis W
authors.initials: FW
authors.lastname: Price
authors.forename: Kendall
authors.initials: K
authors.lastname: Dobbins
authors.forename: William
authors.initials: W
authors.lastname: Zeh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D015242:Ofloxacin / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions; D010539:Permeability; D014295:Trimethoprim / Q000493:pharmacokinetics*
chemical_list: D000891:Anti-Infective Agents, Local; D009883:Ophthalmic Solutions; D015242:Ofloxacin; D014295:Trimethoprim