title: Antibody isotype responses to egg antigens in human chronic Schistosomiasis mansoni before and after treatment.
abstract: In the present communication we analyzed the levels of IgG1, IgG2, IgG3, IgG4 and IgE isotypes to soluble egg antigen of Schistosoma mansoni by ELISA in individuals from an endemic area for schistosomiasis in Northeast Brazil. The analysis was performed before and after treatment to evaluate the age-dependent pattern, and to identify differences in the reactivities to antigens. Our results suggest that schistosomiasis treatment would not interfere with this sort of immune response.
authors.affiliation: Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fiocruz, Recife, PE, 50670-420, Brasil.
authors.forename: Yara M
authors.initials: YM
authors.lastname: Gomes
authors.forename: Valéria R A
authors.initials: VR
authors.lastname: Pereira
authors.forename: Mineo
authors.initials: M
authors.lastname: Nakazawa
authors.forename: Ulisses
authors.initials: U
authors.lastname: Montarroyos
authors.forename: Wayner V
authors.initials: WV
authors.lastname: Souza
authors.forename: Frederico G C
authors.initials: FG
authors.lastname: Abath
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood* / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology*; D001938:Brazil; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D010073:Oxamniquine / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000276:immunology*; D012556:Schistosomicides / Q000627:therapeutic use
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G; D012556:Schistosomicides; D010073:Oxamniquine; D007073:Immunoglobulin E