Toxicity of dietary restriction of fat enriched diets on cardiac tissue.
The present study examines the effects of caloric restriction in cardiac tissue evaluation markers of oxidative stress. High-fat dietary restrictions can have a long-term impact on cardiac health. Dietary restriction of control diet increased myocardial superoxide dismutase (SOD) and catalase activities. Dietary restriction of fatty acid-enriched diets increased myocardial lipoperoxide concentrations, while SOD activity was decreased in cardiac tissue of rats with dietary restriction of fatty acid-enriched diets. Dietary restriction of unsaturated fatty acid-enriched diet induced the highest lipoperoxide concentration and the lowest myocardial SOD activity. Dietary restriction of unsaturated fatty acid decreased myocardial glycogen, and increased the lactate dehydrogenase/citrate synthase ratio. Dietary restriction of fatty acid-enriched diets were more deleterious to cardiac tissue than normal ad lib.-fed diet. In conclusion, the effects of caloric restriction on myocardial oxidative stress is dependent on which nutrient is restricted. Dietary restriction of fatty acid-enriched diets is deleterious relative to ad lib.-fed chow diet.
Diniz
Y S
YS
Post Graduation Course Fisiopatologia em Clínica Médica, Faculty of Medicine, UNESP, Botucatu, São Paulo, Brazil.
Faine
L A
LA
Almeida
J A
JA
Silva
M D P
MD
Ribas
B O
BO
Novelli
E L B
EL
D000818:Animals; D015415:Biomarkers; D002374:Catalase / Q000378:metabolism*; D018752:Diet, Fat-Restricted / Q000009:adverse effects; D004038:Diet, Reducing / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects; D002149:Energy Intake; D008297:Male; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D015415:Biomarkers; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D002374:Catalase; D013482:Superoxide Dismutase