title: Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study.
abstract: The purpose of this study was to identify neuroimaging predictors of medication response in contamination-related obsessive compulsive disorder (OCD). Prior studies of OCD had indicated that glucose metabolic rates within orbitofrontal cortex (OFC) were inversely correlated with subsequent response to serotonergic reuptake inhibitors (SRIs) and that glucose metabolic rates within posterior cingulate cortex (PCC) were positively correlated with subsequent response to cingulotomy. Nine subjects with contamination-related OCD underwent a 12-week open trial of treatment with the SRI fluvoxamine. Percent change in Yale-Brown Obsessive Compulsive Scale score, from pre- to post-treatment, served as the index of treatment response. Positron emission tomography (PET) measurements of regional cerebral blood flow (rCBF) were obtained prior to treatment, in the context of a symptom provocation paradigm. Statistical parametric mapping was used to identify brain loci where pre-treatment rCBF was significantly correlated with subsequent treatment response. Consistent with a priori hypotheses, lower rCBF values in OFC and higher rCBF values in PCC predicted better treatment response. This same pattern of associations was present regardless of whether the imaging data were acquired during a provoked or neutral state. These findings are consistent with prior studies of OCD, indicating that PET indices of brain activity within OFC are inversely correlated with subsequent response to SRIs. In addition, similar to findings regarding cingulotomy for OCD, indices of activity within PCC appear to be positively correlated with response to fluvoxamine as well. Finally, this pattern is sufficiently robust as to be relatively independent of symptomatic state at the time of tracer uptake.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rauch@psych.mgh.harvard.edu
authors.forename: Scott L
authors.initials: SL
authors.lastname: Rauch
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Shin
authors.forename: Darin D
authors.initials: DD
authors.lastname: Dougherty
authors.forename: Nathaniel M
authors.initials: NM
authors.lastname: Alpert
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Fischman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jenike
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D016666:Fluvoxamine / Q000494:pharmacology / Q000627:therapeutic use*; D005544:Forecasting; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D016014:Linear Models; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000523:psychology; D014055:Tomography, Emission-Computed / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D016666:Fluvoxamine