Recombinant follicle-stimulating hormone versus human menopausal gonadotropin in the late follicular phase during ovarian hyperstimulation for in vitro fertilization.
OBJECTIVE
To study the effect of exogenous LH in the late follicular phase on ongoing pregnancies and at the different stages of IVF-ET (stimulation, fertilization, and implantation) in patients with low endogenous LH.


METHODS
Retrospective cohort study with modeling of the different phases of IVF-ET.


METHODS
IVF center of the teaching hospital in Bordeaux, France.


METHODS
Women undergoing IVF and ICSI treatment.


METHODS
One group received recombinant FSH alone (FSH group) and the other received recombinant FSH and hMG in the late follicular phase (i.e., when the largest follicle reached 14 mm) (FSH/hMG group).


METHODS
Ongoing pregnancy, number of oocytes, and number of embryos.


RESULTS
The FSH/hMG group had a higher probability of having at least one oocyte (odds ratio [OR] = 2.75 [1.11-6.80]), of having at least one embryo after oocyte retrieval (OR = 2.84 [1.33-6.07]), and of ongoing pregnancy after ET (OR = 2.04 [0.83-5.01]), and globally had a higher probability of ongoing pregnancy (OR = 2.83 [1.19-6.71]).


CONCLUSIONS
In ovarian hyperstimulation for IVF-ET, LH supplementation in the late follicular phase of women with low endogenous LH is beneficial for ongoing pregnancy by increasing the rate of success of all stages of the treatment.
Commenges-Ducos
Monique
M
Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France. monique.commenges@chu-bordeaux.fr
Piault
Stéphanie
S
Papaxanthos
Aline
A
Ribes
Claude
C
Dallay
Dominique
D
Commenges
Daniel
D
D000328:Adult; D015331:Cohort Studies; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D005498:Follicular Phase; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use*; D015233:Models, Statistical; D016017:Odds Ratio; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data
D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone