title: Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus.
abstract: The goal of this study was to assess the interactive effects of a polynuclear aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), and a co-planar halogenated aromatic hydrocarbon (HAH), 3,3'4,4'5-pentachlorobiphenyl (PCB 126) on ethoxyresorufin-O-deethylase (EROD) activity and occurrence of deformities in Fundulus heteroclitus. While each compound administered alone elicited dose-dependent increases in EROD activity, the combined treatment of these two compounds generally did not elicit an additive EROD response. There was a significant correlation between deformity occurrence and EROD induction in embryos dosed with PCB alone but not for embryos dosed with BaP alone, or a combination of BaP and PCB 126.
authors.affiliation: Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, NC 27708, USA. deena@duke.edu
authors.forename: Deena M
authors.initials: DM
authors.lastname: Wassenberg
authors.forename: Erin E
authors.initials: EE
authors.lastname: Swails
authors.forename: Richard T
authors.initials: RT
authors.lastname: Di Giulio
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000009:adverse effects*; D002273:Carcinogens / Q000009:adverse effects*; D000013:Congenital Abnormalities / Q000209:etiology* / Q000662:veterinary*; D019363:Cytochrome P-450 CYP1A1 / Q000187:drug effects* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004625:Embryo, Nonmammalian / Q000187:drug effects; D047108:Embryonic Development; D004781:Environmental Exposure; D004790:Enzyme Induction; D004965:Estrogen Antagonists / Q000009:adverse effects*; D023781:Fundulidae / Q000196:embryology* / Q000502:physiology; D011078:Polychlorinated Biphenyls / Q000009:adverse effects*
chemical_list: D002273:Carcinogens; D004965:Estrogen Antagonists; D001564:Benzo(a)pyrene; D011078:Polychlorinated Biphenyls; D019363:Cytochrome P-450 CYP1A1; C023035:3,4,5,3',4'-pentachlorobiphenyl