Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system.
Apolipoprotein E (ApoE), a constituent of the lipoproteins, may be relevant in herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS), since HSV-1 binds to human serum ApoE lipoproteins. This study demonstrates the involvement of ApoE in the hematogenous route of HSV-1 to the CNS.
Burgos
Javier S
JS
Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Ramirez
Carlos
C
Sastre
Isabel
I
Bullido
María J
MJ
Valdivieso
Fernando
F
D000818:Animals; D001057:Apolipoproteins E / Q000097:blood* / Q000172:deficiency / Q000235:genetics; D002490:Central Nervous System / Q000821:virology; D002494:Central Nervous System Infections / Q000097:blood* / Q000821:virology*; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005260:Female; D006561:Herpes Simplex / Q000097:blood* / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009928:Organ Specificity; D011485:Protein Binding; D013997:Time Factors; D014766:Viremia / Q000097:blood / Q000821:virology
D001057:Apolipoproteins E; D004279:DNA, Viral