title: Anxiolytic and antiemetic activity of Zingiber officinale.
abstract: The benzene fraction (BF) of a petroleum ether extract of dried rhizomes of ginger, which contained anticonvulsant principle(s), was screened for anxiolytic and antiemetic activity. Motor coordination was not affected by BF per se, but diazepam-induced motor incoordination was potentiated. Animals treated with BF showed decreased occupancy in the closed arm of the elevated plus maze suggesting the presence of anxiolytic principles in the BF. BF also blocked lithium sulphate-induced conditioned place aversion indicating antiemetic activity. These findings suggest that the fraction (BF) possesses anticonvulsant, anxiolytic and antiemetic activity.
authors.affiliation: N.D.M.V.P. Samaj's College of Pharmacy, Nashik - 422 002, India.
authors.forename: S L
authors.initials: SL
authors.lastname: Vishwakarma
authors.forename: S C
authors.initials: SC
authors.lastname: Pal
authors.forename: Veena S
authors.initials: VS
authors.lastname: Kasture
authors.forename: S B
authors.initials: SB
authors.lastname: Kasture
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000932:Antiemetics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects; D020939:Zingiber officinale; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D010433:Pentylenetetrazole; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000932:Antiemetics; D010936:Plant Extracts; D010433:Pentylenetetrazole