[The role of HLA-B27 molecules in the pathogenesis of ankylosing spondylitis].
Ankylosing Spondylitis (AS) is characterised by the strongest association with an HLA antigen ever described for any disease. It represents therefore the ideal model for the understanding of the link between immune-mediated diseases and the HLA system. The role of HLA-B27 in the pathogenesis of AS will be discussed focusing on the recently described higher expression of these molecules in patients with AS compared with healthy controls.
Cauli
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A
Cattedra di Reumatologia II, Dipartimento di Scienze Mediche, Università degli Studi di Cagliari. cauli@medicina.unica.it
Dessole
G
G
Nurchis
P P
PP
Vacca
A
A
Mameli
A
A
Garau
P
P
Pala
R
R
Passiu
G
G
Mathieu
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A
D019943:Amino Acid Substitution; D000818:Animals; D030801:Animals, Genetically Modified; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology; D001324:Autoantigens / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D017637:Clonal Deletion; D016207:Cytokines / Q000096:biosynthesis; D005006:Ethnicity / Q000235:genetics; D015870:Gene Expression; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000276:immunology; D008954:Models, Biological; D018716:Molecular Mimicry; D016328:NF-kappa B / Q000378:metabolism; D017510:Protein Folding; D051381:Rats; D012763:Shigella flexneri / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000209:etiology* / Q000276:immunology
D000942:Antigens, Bacterial; D001324:Autoantigens; D016207:Cytokines; D015796:HLA-B27 Antigen; D016328:NF-kappa B