Methodologies in cancer cytogenetics and molecular cytogenetics.
Various types of cytogenetic and molecular cytogenetic approaches, including conventional banding, fluorescence in situ hybridization (FISH), fiber-FISH, comparative genomic hybridization (CGH), matrix array CGH, chromosome microdissection, and microcell-mediated chromosome transfer are summarized. The rationale, advantage, and limitations of each approach are discussed with respect to research and clinical applications in human neoplasia.
Wang
Nancy
N
School of Rochester, University of Rochester, NY, USA. nancy_wang@urmc.rochester.edu
D002871:Chromosome Banding / Q000379:methods; D020732:Cytogenetic Analysis / Q000379:methods*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008867:Microtomy / Q000379:methods; D009369:Neoplasms / Q000235:genetics*