Nonhuman primate transgenesis: progress and prospects.
The nonhuman primate is used extensively in biomedical research owing to its close similarities to human physiology and human disease pathophysiology. Recently, several groups have initiated efforts to genetically manipulate nonhuman primates to address complex questions concerning primate-specific development and physiological adaptation. Primates pose unique challenges to transgenesis and, although this field is still in its infancy, the potential for obtaining new insights into primate physiology and gene function is unprecedented. This review focuses on the methods and potential applications of genetically altered nonhuman primates in biomedical research.
Wolfgang
Michael J
MJ
Yale University School of Medicine, Dept of Pathology, New Haven, CT 06520, USA.
Golos
Thaddeus G
TG
D000222:Adaptation, Physiological; D000818:Animals; D030801:Animals, Genetically Modified / Q000502:physiology*; D035843:Biomedical Research; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques / Q000639:trends*; D005818:Genetic Engineering / Q000379:methods* / Q000639:trends*; D006801:Humans; D011323:Primates / Q000235:genetics*; D019076:Transgenes