Pine resin and Biopin ointment: effects on repair processes in tissues.
The effects of Biopin (ointment containing pine resin) used in the treatment of burns, wounds, and pyoinflammatory processes on cell composition of the wound surface (smears) and granulation tissue were studied on rats. In vitro antibacterial activity of the drug was also evaluated. At the early stage of inflammation Biopin modulated the nonspecific and inhibited specific cell immune response, normalized hemodynamics in the inflammation focus, activated synthetic processes in the wound, and was effective towards anaerobes and bacilli.
Simbirtsev
A S
AS
State Institute of Extra Pure Biopreparations, St. Petersburg.
Konusova
V G
VG
Mchelidze
G Sh
GSh
Fidarov
E Z
EZ
Paramonov
B A
BA
Chebotarev
V Yu
VY
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D007107:Immune System / Q000187:drug effects; D008297:Male; D009824:Ointments / Q000627:therapeutic use*; D051381:Rats; D012116:Resins, Plant / Q000627:therapeutic use*; D013997:Time Factors; D014945:Wound Healing
D000596:Amino Acids; D000890:Anti-Infective Agents; D009824:Ointments; D012116:Resins, Plant; C013893:rosin