title: CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells.
abstract: Follicular lymphomas (FLs) localize in lymphoid tissues and recapitulate the structure of normal secondary follicles. The chemokine/chemokine receptor pair CXCL13/CXCR5 is required for the architectural organization of B cells within lymphoid follicles. In this study, we showed that CXCL13 was secreted by FL cells. FL cells expressed CXCR5 and migrated in response to CXCL13. Furthermore, we observed a synergistic effect between CXCL13 and CXCL12 (SDF-1), a chemokine produced by stromal cells in lymphoid tissues. The production of CXCL13 by FL cells and CXCL12 by stromal cells probably directs and participates in the accumulation of FL cells within specific anatomic sites.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Hervé
authors.initials: H
authors.lastname: Husson
authors.forename: Arnold S
authors.initials: AS
authors.lastname: Freedman
authors.forename: Angelo A
authors.initials: AA
authors.lastname: Cardoso
authors.forename: Joachim
authors.initials: J
authors.lastname: Schultze
authors.forename: Olivier
authors.initials: O
authors.lastname: Munoz
authors.forename: Giuliana
authors.initials: G
authors.lastname: Strola
authors.forename: Jeffery
authors.initials: J
authors.lastname: Kutok
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Carideo
authors.forename: Rosalie
authors.initials: R
authors.lastname: De Beaumont
authors.forename: Federico
authors.initials: F
authors.lastname: Caligaris-Cappio
authors.forename: Paolo
authors.initials: P
authors.lastname: Ghia
mesh_terms: D017209:Apoptosis; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D023201:CD40 Ligand / Q000494:pharmacology; D002478:Cells, Cultured; D054382:Chemokine CXCL13; D019743:Chemokines, CXC / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D005434:Flow Cytometry; D006801:Humans; D015847:Interleukin-4 / Q000494:pharmacology; D008224:Lymphoma, Follicular / Q000378:metabolism* / Q000473:pathology; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000378:metabolism; D013268:Stimulation, Chemical; D014407:Tumor Cells, Cultured
chemical_list: C110663:CXCL13 protein, human; C095085:CXCR5 protein, human; D054382:Chemokine CXCL13; D019743:Chemokines, CXC; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D023201:CD40 Ligand; D015847:Interleukin-4