title: [Oxidative profile of tonsil infection. Study of antioxidant enzymes in tonsil and blood].
abstract: In order to investigate the effect of oxidative damage due to free radicals on ENT infectious diseases, levels of superoxide dismutase (SOD), glutathione-peroxidase (GPx) and reductase (GRt) and the total antioxidant status (TAS) were measured by spectrophotometry on tonsillar tissue obtained from tonsillectomy in 538 patients, who were divided in three groups according to their surgical indication: tonsillar hypertrophy (n = 235), recurrent tonsillitis (n = 280) or peritonsillar abscess (n = 23). SOD concentration were also measured on adenoid tissue and middle ear exudate in 75 patients from the first two groups. Erythrocyte and tonsillar SOD levels were significantly greater in the abscess group, and lower in the hypertrophic one. These differences were similar for GPx and TAS. For GRt, its level in abscess were lower than in the other two groups in a statistically significant way. There were strong correlations between erythrocyte and tonsillar SOD, tonsillar SOD and GPx, tonsillar SOD and TAS, and tonsillar GPx and TAS. SOD concentrations from adenoid tissue and middle ear exudate did not affect its blood level. So, we can conclude that tonsillar oxidative damage is determined by the frequency or the severity of local infections, and it can be evaluated by measuring the SOD concentration in the tonsillar tissue or in the peripheral blood. So, it can be considered a good marker of tonsillar damage.
authors.affiliation: Servicio de ORL, Hospital Clínico Universitario, Valencia.
authors.forename: F J
authors.initials: FJ
authors.lastname: García Callejo
authors.forename: M H
authors.initials: MH
authors.lastname: Orts Alborch
authors.forename: M M
authors.initials: MM
authors.lastname: Velert Vila
authors.forename: E N
authors.initials: EN
authors.lastname: Fernández Julián
authors.forename: L
authors.initials: L
authors.lastname: Blay Galaud
authors.forename: J
authors.initials: J
authors.lastname: Marco Algarra
mesh_terms: D000234:Adenoids / Q000201:enzymology; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005122:Exudates and Transudates / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000032:analysis* / Q000097:blood; D005980:Glutathione Reductase / Q000032:analysis* / Q000097:blood; D006801:Humans; D008297:Male; D009928:Organ Specificity; D010035:Otitis Media, Suppurative / Q000201:enzymology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014066:Palatine Tonsil / Q000201:enzymology*; D000039:Peritonsillar Abscess / Q000201:enzymology; D012008:Recurrence; D013482:Superoxide Dismutase / Q000032:analysis* / Q000097:blood; D014069:Tonsillitis / Q000201:enzymology*
chemical_list: D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase