title: Single stroke dementia: insights from 12 cases in Singapore.
abstract: BACKGROUND
  Vascular dementia (VaD) is occasionally caused by a single, strategically located stroke. In this report, we describe the clinical and anatomical features of 12 cases of strategic single infarct dementia (SSID) from Singapore.
  
  
  METHODS
  Each patient completed a standardized diagnostic evaluation including history, neurological and neuropsychological examination, laboratory testing, and brain imaging. Dementia was diagnosed using the Diagnostic and Statistical Manual, 3rd edition, revised (DSM-III-R) criteria, and VaD was diagnosed using the National Institute of Neurologic Disorders and Stroke and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN) criteria. VaD patients whose brain imaging study revealed a single cerebrovascular event were diagnosed with SSID.
  
  
  RESULTS
  We identified 12 cases of SSID among 125 VaD patients (9.6%). Stroke mechanism was lacunar infarction in five cases, embolism in four cases, large vessel thrombosis in two cases, and parenchymal hemorrhage in one case. The most commonly impaired cognitive domains on neuropsychological testing were visual memory, visuoconstruction, and language. In 11 of the 12 SSID cases, the stroke was located in the left hemisphere. The thalamus, either alone or as the proximal portion of a posterior cerebral artery infarction, was involved in 8 of the 12 cases. Stroke locations in the nonthalamic SSID cases included left angular gyrus, subcortical left frontal lobe including minor forceps, left basal forebrain and medial frontal lobe plus anterior corpus callosum (proximal anterior cerebral artery infarction), and anterior corpus callosum alone.
  
  
  CONCLUSIONS
  Various stroke mechanisms may produce SSID. In our SSID cases, vascular damage almost always involved the left hemisphere and frequently involved the thalamus and major interhemispheric or intrahemispheric white matter pathways.
authors.affiliation: Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. gnrale@sgh.gov.sg
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Auchus
authors.forename: Christopher P L H
authors.initials: CP
authors.lastname: Chen
authors.forename: Swati N
authors.initials: SN
authors.lastname: Sodagar
authors.forename: Melissa
authors.initials: M
authors.lastname: Thong
authors.forename: Eugene C S
authors.initials: EC
authors.lastname: Sng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D016208:Databases, Factual; D003704:Dementia / Q000209:etiology* / Q000473:pathology / Q000523:psychology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012846:Singapore; D020521:Stroke / Q000150:complications* / Q000473:pathology / Q000523:psychology*