Nitroglycerin in septic shock after intravascular volume resuscitation.
In patients with septic shock, oxygen consumption is increased, but oxygen delivery and extraction is impaired, partly because of microcirculatory shutdown and shunting. Orthogonal polarisation spectral (OPS) imaging allows visualisation of the microcirculation. We used this technique to assess microcirculatory flow in septic-shock patients who had a mean arterial blood pressure of more than 60 mm Hg and central venous pressure greater than 12 mm Hg. The infusion of 0.5 mg of nitroglycerin intravenously then resulted in a marked increase in microvascular flow on OPS imaging. Improved recruitment of the microcirculation could be a new resuscitation endpoint in septic shock.
Spronk
Peter E
PE
Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands.
Ince
Can
C
Gardien
Martin J
MJ
Mathura
Keshen R
KR
Oudemans-van Straaten
Heleen M
HM
Zandstra
Durk F
DF
D018806:APACHE; D000328:Adult; D000368:Aged; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D006801:Humans; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D005996:Nitroglycerin