title: High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men.
abstract: There is evidence that gastrointestinal function adapts in response to a high-fat (HF) diet. This study investigated the hypothesis that an HF diet modifies the acute effects of duodenal lipid on appetite, antropyloroduodenal pressures, plasma CCK and plasma glucagon-like peptide-1 (GLP-1) levels in humans. Twelve healthy men were studied twice in randomized, crossover fashion. The effects of a 90-min duodenal lipid infusion (6.3 kJ/min) on the above parameters were assessed immediately following 14-day periods on either an HF or a low-fat (LF) diet. After the HF diet, pyloric tonic and phasic pressures were attenuated, and the number of antropyloroduodenal pressure-wave sequences was increased when compared with the LF diet. Plasma CCK and GLP-1 levels did not differ between the two diets. Hunger was greater during the lipid infusion following the HF diet, but there was no difference in food intake. Therefore, exposure to an HF diet for 14 days attenuates the effects of duodenal lipid on antropyloroduodenal pressures and hunger without affecting food intake or plasma hormone levels.
authors.affiliation: University of Adelaide, Department of Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
authors.forename: K A
authors.initials: KA
authors.lastname: Boyd
authors.forename: D G
authors.initials: DG
authors.lastname: O'Donovan
authors.forename: S
authors.initials: S
authors.lastname: Doran
authors.forename: J
authors.initials: J
authors.lastname: Wishart
authors.forename: I M
authors.initials: IM
authors.lastname: Chapman
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
authors.forename: C
authors.initials: C
authors.lastname: Feinle
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects*; D002766:Cholecystokinin / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004386:Duodenum / Q000502:physiology*; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D005934:Glucagon / Q000097:blood; D052216:Glucagon-Like Peptide 1; D006728:Hormones / Q000097:blood*; D006801:Humans; D006815:Hunger / Q000502:physiology; D007441:Intubation, Gastrointestinal; D008297:Male; D009129:Muscle Tonus / Q000502:physiology; D010446:Peptide Fragments / Q000097:blood; D011498:Protein Precursors / Q000097:blood; D011708:Pylorus / Q000502:physiology
chemical_list: D004041:Dietary Fats; D006728:Hormones; D010446:Peptide Fragments; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D002766:Cholecystokinin