[Telomerase: an enzyme with multiple applications in cancer research].
The telomerase is a ribonucleoprotein enzyme to which multiple functions have been attributed, the most important of these is the maintenance of the telomere which is related with cellular immortalization and cancer. 85% of human tumors have telomerase activity, that in normal cells goes undetected. These characteristics make the telomerase an attractive target for chemotherapy.
Castillo Ureta
Hipólito
H
Laboratorio de Biología Celular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
Barrera Saldaña
Hugo A
HA
Martínez Rodríguez
Herminia G
HG
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology / Q000627:therapeutic use; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D000077209:Decitabine; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004790:Enzyme Induction; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy; D006801:Humans; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016615:Telomere / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology
D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D004791:Enzyme Inhibitors; D009363:Neoplasm Proteins; D000077209:Decitabine; D019098:Telomerase; D001374:Azacitidine