title: Molecular and biologic basis of upper gastrointestinal malignancy. Gastric carcinoma.
abstract: Gastric cancer is one of the world's most common cancers and is a leading cause of cancer death worldwide. Neoplasia of the stomach is mainly composed of adenocarcinomas, which for more than 95% of cases. Although mesenchymal tumors (i.e., stromal tumors, leiomyomas and leiomyosarcomas, and schwannomas), primary lymphomas, and carcinoid tumors can also arise in the stomach, malignant tumors of these types occur much less often.
authors.affiliation: Department of Medicine, Division of Gastroenterology and Hepatology, University of Virginia, Box 800798, Charlottesville, VA 22908-0708, USA.
authors.forename: Wa'el
authors.initials: W
authors.lastname: el-Rifai
authors.forename: Steven M
authors.initials: SM
authors.lastname: Powell
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000503:physiopathology*; D051546:Cyclooxygenase 2; D003598:Cytoskeletal Proteins / Q000235:genetics; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D019656:Loss of Heterozygosity / Q000502:physiology; D008565:Membrane Proteins; D018895:Microsatellite Repeats / Q000235:genetics; D009693:Nucleic Acid Hybridization; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics / Q000503:physiopathology*; D015534:Trans-Activators / Q000235:genetics; D051176:beta Catenin
chemical_list: C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D007527:Isoenzymes; D008565:Membrane Proteins; D015534:Trans-Activators; D051176:beta Catenin; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases