New reactions in clavulanic acid biosynthesis.
Clavulanic acid is only a modestly effective antibiotic against bacterial infections in humans, but a potent inhibitor/inactivator of beta-lactamase enzymes that confer bacterial resistance. The biosynthetic pathway to clavulanic acid is considerably more complex than that to the structurally related penicillins and cephalosporins and has revealed several interesting reactions.
Townsend
Craig A
CA
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA. ctownsend@jhu.edu
D000581:Amidohydrolases / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D019818:Clavulanic Acid / Q000096:biosynthesis* / Q000737:chemistry; D033862:Iron-Binding Proteins / Q000737:chemistry; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D033862:Iron-Binding Proteins; D019818:Clavulanic Acid; D006899:Mixed Function Oxygenases; C066046:clavaminate synthase; D000581:Amidohydrolases