Generation of reactive oxygen species by mitochondria in senescence-accelerated OXYS rats.
Chemiluminescence assay showed that oxygen reduction and production of superoxide anion and hydrogen peroxide by liver mitochondria in OXYS rats highly sensitive to oxidative stress were less intensive than in Wistar rats. Experiments with cytochrome c oxidase inhibitors showed that decreased O2-. generation in mitochondria of OXYS rats is probably associated with changes in complex III of the electron transport chain.
Men'shchikova
E B
EB
Research Center for Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. lemen@online.sinor.ru
Shabalina
I G
IG
Zenkov
N K
NK
Kolosova
N G
NG
D000375:Aging / Q000502:physiology*; D000818:Animals; D008163:Luminescent Measurements; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013223:Statistics as Topic
D017382:Reactive Oxygen Species