title: The (theoretical) yin and yang of spindle mechanics.
abstract: Antiparallel overlap of microtubules is central to the morphogenesis of bipolar mitotic spindles. How does this overlap arise, and how is it maintained? A recent theoretical study uses computer simulations to investigate whether motor protein complexes can achieve this task. The "virtual" results reveal that a mixed polarity motor complex is needed to do the job.
authors.affiliation: Max Planck Institute of Cell Biology and Genetics, Dresden, Germany.
authors.forename: Arshad
authors.initials: A
authors.lastname: Desai
mesh_terms: D000818:Animals; D003198:Computer Simulation; D020409:Molecular Motor Proteins; D008941:Spindle Apparatus; D014981:Xenopus
chemical_list: D020409:Molecular Motor Proteins