Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals.
We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.
Martinez-Picado
Javier
J
IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain. javiermp@ns.hubtip.scs.es
Frost
Simon D W
SD
Izquierdo
Nuria
N
Morales-Lopetegi
K
K
Marfil
Silvia
S
Puig
Teresa
T
Cabrera
Cecilia
C
Clotet
Bonaventura
B
Ruiz
Lidia
L
D000328:Adult; D000956:Antigens, Viral / Q000235:genetics; D023241:Antiretroviral Therapy, Highly Active; D001483:Base Sequence; D019143:Evolution, Molecular; D015752:Genes, env; D014644:Genetic Variation; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000097:blood / Q000235:genetics
D000956:Antigens, Viral; D012367:RNA, Viral