The study of biocompatibility of super high molecular weight poly D,L-lactic acid implant.
OBJECTIVE
To evaluate the biocompatibility of the super high molecular weight poly D,L-lactic acid (SHMW-PDLLA) implant.


METHODS
The SHMW-PDLLA plates were implanted into the SD-rats between the masseter and ramus of the mandible. The blood specimens were gained at 3, 6, 9, 12 months after the operation. The proteins, electrolyte, enzyme and other indices were tested by use of Beckman automatic biochemical analysis device. The soft tissue specimens around the SHMW-PDLLA plates were gained at 3, 6, 9, 12 months after the operation and the tissue reaction was observed with the pathological and haematological methods.


RESULTS
There were not any abnormal findings in the blood after the SHMW-PDLLA plates implanted in the body of SD-rats. The implanted SHMW-PDLLA plates were degraded gradually in 6 to 12 months after the operation. There was not any abnormal tissue reaction found to the soft tissue around the SHMW-PDLLA plates by histological and pathological observations.


CONCLUSIONS
The SHMW-PDLLA implant has a good biocompatibility to SD-rats.
Wei
Shicheng
S
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Zheng
Qian
Q
Liu
Lei
L
Li
Shengwei
S
Wang
Hanzhang
H
Xiong
Chengdong
C
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001860:Bone Plates; D019344:Lactic Acid / Q000737:chemistry; D008334:Mandible; D008970:Molecular Weight; D019736:Prostheses and Implants
D001672:Biocompatible Materials; D019344:Lactic Acid