[Multilevel regulation of tyrosine hydroxylase. I. Posttranscriptional levels].
The tyrosine hydroxylase plays a key role in the catecholamine synthesis responding to many stimuli disturbing homeostasis. In this part we described the posttranscriptional levels of the gene and the protein regulation including: alternative splicing, isoform specificity, feedback inhibition, protein phosphorylation and dephosphorylation, protein stability, translational regulation.
Lenartowski
Robert
R
Pracownia Genetyki Instytutu Biologii Ogólnej i Molekularnej UMK w Toruniu. rlenart@eagle.biol.uni.torun.pl
Goc
Anna
A
D000818:Animals; D002395:Catecholamines / Q000096:biosynthesis*; D005786:Gene Expression Regulation / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics* / Q000378:metabolism*
D002395:Catecholamines; D014446:Tyrosine 3-Monooxygenase