Tritium labelling and characterization of the cognition enhancing drug tacrine using several precursors.
Tacrine and its analogues have shown promise as cognition enhancers and potential chemotherapeutic agents for Alzheimer's disease. [3H]tacrine was required to explore its mechanism of action via receptor binding assay and the radioligand was prepared by means of catalytic dehalogenation of several brominated precursors.
Egan
Judith A
JA
PerkinElmer Life Sciences, Inc, 549 Albany St, Boston, MA 02118, USA.
Nugent
Richard P
RP
Filer
Crist N
CN
D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D018697:Nootropic Agents / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013619:Tacrine / Q000031:analogs & derivatives / Q000737:chemistry*; D014316:Tritium
D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents; D014316:Tritium; D013619:Tacrine