title: DICER-LIKE1: blind men and elephants in Arabidopsis development.
abstract: Genetic studies of embryo, ovule and flower development in Arabidopsis thaliana have led to the independent isolation of different mutant alleles of a single gene (SIN1/SUS1/CAF, now renamed DCL1) that encodes a complex RNA-processing enzyme. DCL1 shows similarity to the Dicer group of genes, which are required for RNA silencing in Drosophila and Caenorhabditis. These recent findings identify a novel but conserved mechanism of post-transcriptional gene regulation that is important for development in eukaryotes.
authors.affiliation: Dept of Biology, University of Rochester, NY 14627, USA.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Schauer
authors.forename: Steven E
authors.initials: SE
authors.lastname: Jacobsen
authors.forename: David W
authors.initials: DW
authors.lastname: Meinke
authors.forename: Animesh
authors.initials: A
authors.lastname: Ray
mesh_terms: D000483:Alleles; D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D004722:Endoribonucleases / Q000235:genetics* / Q000378:metabolism; D035264:Flowers / Q000235:genetics / Q000254:growth & development; D017343:Genes, Plant / Q000235:genetics; D009154:Mutation; D034622:RNA Interference; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism; D043244:Ribonuclease III; D012639:Seeds / Q000235:genetics / Q000254:growth & development
chemical_list: D029681:Arabidopsis Proteins; D018797:Cell Cycle Proteins; D018749:RNA, Plant; D004722:Endoribonucleases; C402383:DCL1 protein, Arabidopsis; D043244:Ribonuclease III