The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant.
The use of local antibiotics from a biodegradable implant for chronic osteomyelitis is an attractive alternative. The implant delivers high tissue levels, obliterates dead space, aids bone repair and does not need to be removed. The purpose of this paper is to review our early clinical experience with custom-made calcium sulfate (Osteoset bone void filler) antibiotic-impregnated implants.
Gitelis
Steven
S
Rush Medical College, Chicago, Illinois 60612, USA.
Brebach
Gregory T
GT
D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002133:Calcium Sulfate / Q000627:therapeutic use; D002908:Chronic Disease; D016503:Drug Delivery Systems / Q000379:methods; D004343:Drug Implants; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy*; D014031:Tobramycin / Q000008:administration & dosage*; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D004343:Drug Implants; D014640:Vancomycin; D014031:Tobramycin; D002133:Calcium Sulfate