Inherited movement disorders.
The inherited movement disorders comprise a rapidly growing category of human disease. Advances in genetics have led to the identification of the gene mutation in Huntington's disease and three different gene mutations, which may lead to Parkinson's disease. In addition, gene mutations have been identified in less common movement disorders including Wilson's disease, Hallervorden-Spatz syndrome, paroxysmal kinesogenic choreoathetosis, neuroacanthocytosis, and some forms of dystonia. This article summarizes what is known about the genetic mutations that cause these movement disorders, as well as the clinical features of each disease and the symptomatic treatments currently available.
Sharma
Nutan
N
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Standaert
David G
DG
D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X; D005799:Genes, Dominant / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D009069:Movement Disorders / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D018433:Twin Studies as Topic
D005819:Genetic Markers