Antioxidant activity of blood plasma in individuals with neoplasms.
In 3 groups of patients with neoplasms plasma antioxidant activity was measured by the yield of TBA-reactive products generated in lecithin-Fe(2+) model system. Patients with laryngeal, tongue, oropharyngeal, oral, and laryngopharyngeal tumors showed lower plasma antioxidant activity compared to patients with breast, lung, and bronchial cancer (p<0.005). In women with breast cancer plasma antioxidant activity increased with age (p<0.05). Possible mechanisms underlying these fluctuations are discussed. It is assumed that plasma antioxidant activity is relatively stable and modulates body resistance to tumor process.
Marusin
A V
AV
Institute of Medical Genetics, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences. marussin@img.tsu.ru
Salyukov
V B
VB
Bragina
E Yu
EY
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D010713:Phosphatidylcholines / Q000378:metabolism; D010949:Plasma / Q000378:metabolism*; D012737:Sex Factors
D000975:Antioxidants; D010713:Phosphatidylcholines; D007501:Iron