title: Plasma lidocaine concentrations after local anesthesia of the groin for cardiac catheterization.
abstract: This study aimed to investigate serum lidocaine concentrations after subcutaneous infiltration of the groin for cardiac catheterization. One hundred twenty-six patients for planned heart catheterization received five different dosages (5-25 ml) of lidocaine 2% for local anesthesia of the groin in a randomized manner. All of them received an arterial sheath and 13 received both an arterial sheath and a venous sheath for right heart catheterization. Blood samples were taken before as well as 15, 30, and 120 min after subcutaneous application of the drug. Although in 33 patients with an arterial sheath (no venous sheath) excessive doses of lidocaine 2% (20-25 ml) were used, neither symptoms of intoxication nor toxic plasma levels were observed. However, in patients receiving an additional venous sheath, toxic plasma levels were obtained in a third of the cases. One of them showed symptoms of intoxication.
authors.affiliation: Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätskliniken des Saarlandes, Homburg/Saar, Germany. angelikaguth@web.de
authors.forename: Angelika
authors.initials: A
authors.lastname: Guth
authors.forename: Benno
authors.initials: B
authors.lastname: Hennen
authors.forename: Thomas
authors.initials: T
authors.lastname: Krämer
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Stoll
authors.forename: Michael
authors.initials: M
authors.lastname: Böhm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D006328:Cardiac Catheterization; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006119:Groin; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood; D059408:Pain Management; D011677:Punctures; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine