Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease.
Ancestral medicinal use of guava (Psidium guajava L. Fam. Myrtaceae) is today supported by numerous biomedical studies concerning the properties of leaf extracts. However, insufficient clinical studies are reported on the use of this plant resource in the treatment of gastrointestinal ailments. The present work reports a randomized, double-blinded, clinical study performed to evaluate the safety and efficacy of a phytodrug (QG-5) developed from guava leaves, standardized in its content of quercetin and orally administered to a group of adult patients with acute diarrheic disease. Capsules containing 500 mg of the product were administered to 50 patients every 8 h during 3 days. Results obtained showed that the used guava product decreased the duration of abdominal pain in these patients.
Lozoya
Xavier
X
Laboratory of Medicinal Plants at Research Unit of Neurological Diseases, Mexican Institute of Social Security (IMSS), Mexico City, Mexico. 4509@axtel.net
Reyes-Morales
Hortensia
H
Chávez-Soto
Marco A
MA
Martínez-García
María del Carmen
Mdel C
Soto-González
Yolanda
Y
Doubova
Svetlana V
SV
D000208:Acute Disease; D000328:Adult; D000930:Antidiarrheals / Q000008:administration & dosage / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D018515:Plant Leaves; D031647:Psidium; D016896:Treatment Outcome
D000930:Antidiarrheals; D010276:Parasympatholytics; D010936:Plant Extracts