Occurrence of multiple myeloma in both donor and recipient after bone marrow transplantation.
The transplantation of malignant cells during allogeneic transplant is a rare occurrence. 27 months after donating progenitor cells, a diagnosis of multiple myeloma was made in a 6/6 HLA-phenotypically matched unrelated donor. The 42-year-old recipient transplanted for chronic phase chronic myeloid leukemia developed IgA myeloma 40 months after transplantation. Serum electrophoresis and bone marrow investigations established the diagnosis of IgA K multiple myeloma in both. This case illustrates the natural history and biology of multiple myeloma.
Kumar
Arun
A
College of Medicine, Drexel University, 245 North 15th Street, Philadelphia, PA 19102, USA.
Styler
Michael J
MJ
Topolsky
David L
DL
Crilley
Pamela A
PA
Przybysz
Thomas M
TM
Gladstone
Douglas E
DE
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery*; D008297:Male; D009101:Multiple Myeloma / Q000209:etiology*; D014019:Tissue Donors