title: Experience of intravenous digital subtraction angiography (IV-DSA) in evaluation of neoadjuvant chemotherapy for advanced breast cancer.
abstract: Intravenous digital subtraction angiography (IV-DSA) was performed before and after neoadjuvant chemotherapy (NACT) in five patients with locally advanced breast cancer, and the efficacy of NACT was evaluated on the basis of the results of IV-DSA and histopathological examination. Following NACT, the maximum density of tumor enhancement (MAX) in the IV-DSA image decreased by 61.6% in case 1, 50% in case 2, 58.1% in case 3, 90.8% in case 4, and 97.2% in case 5. In all five patients, the efficacy of chemotherapy was rated as a partial response in terms of tumor size, while histological efficacy was rated as slightly effective in cases 1-4 and moderately effective in case 5. The pathological efficacy of NACT was highest in case 5, which showed the greatest decrease in MAX. These results indicate that variations in MAX reflect clinical efficacy, and, to some extent, also permit prediction of pathological efficacy.
authors.affiliation: Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishi-ogu, Arakawa-ku, Tokyo 116-8567, Japan. watanosu@dnh.twmu.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Haga
authors.forename: Tadao
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Jun
authors.initials: J
authors.lastname: Kinoshita
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Utada
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Okabe
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Kimura
authors.forename: Akira
authors.initials: A
authors.lastname: Hirano
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kajiwara
authors.forename: Motohiko
authors.initials: M
authors.lastname: Aiba
mesh_terms: D015901:Angiography, Digital Subtraction; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007479:Iopamidol / Q000008:administration & dosage; D008875:Middle Aged; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media; D007479:Iopamidol