Fatty acid desaturation: variations on an oxidative theme.
Significant progress in our understanding of the mechanism of fatty acid desaturation has been achieved. The site of initial oxidation has been determined for several membrane-bound desaturases and a common cryptoregiochemical theme has been revealed. The results of several studies, including a detailed analysis of a soluble plant desaturase system, point to a close mechanistic relationship between dehydrogenation and hydroxylation pathways.
Behrouzian
Behnaz
B
Maxygen Inc., 515 Galveston Drive, Redwood City, CA 94063, USA.
Buist
Peter H
PH
D000818:Animals; D001665:Binding Sites; D044943:Fatty Acid Desaturases / Q000737:chemistry* / Q000378:metabolism; D006900:Hydroxylation; D007313:Insecta; D007425:Intracellular Membranes / Q000201:enzymology; D007700:Kinetics; D008956:Models, Chemical; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010944:Plants; D013379:Substrate Specificity
D044943:Fatty Acid Desaturases