Ultrastructural morphology of a middle ear ceruminoma.
The ultrastructural morphology of a ceruminous gland adenoma in the middle ear was examined electron microscopically. The epithelial tumor cells displayed apocrine caps, microvilli, cell junctions, secretory granules, vacuoles, lipid droplets and siderosomes, which are the characteristic ultrastructural features of apocrine glands. Concentric membranous bodies of the endoplasmic reticulum, phagocytic activity of the tumor cells, intracytoplasmic lumina, ciliated cells and also spiny collagen in the tumor stroma could be seen. The myoepithelial cells are an important tumor marker in the differential diagnosis between ceruminomas and adenomas of the middle ear. The ectopic origin in the modified apocrine ceruminous glands, the specific localization, the clinical features and the extremely rare occurrence of the ceruminoma makes this tumor a unique neoplastic entity.
Schenk
Peter
P
Department of Otorhinolaryngology, Vienna Medical School, Währinger Gürtel 18-20, A-1090 Vienna, Vienna, Austria. HNO@univie.ac.at
Handisurya
Alessandra
A
Steurer
Martin
M
D000236:Adenoma / Q000648:ultrastructure*; D001050:Apocrine Glands / Q000648:ultrastructure*; D002571:Cerumen; D004432:Ear, Middle; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D013544:Sweat Gland Neoplasms / Q000648:ultrastructure*