Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH, Chiralcel OJ-R and Chirobiotic-T phases.
This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out of seven compounds investigated, six were resolved with baseline resolution with at least one of the three columns.
Visegrády
Balázs
B
Central Research Laboratory, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7643 Pécs, Hungary.
Konecsni
Tünde
T
Grobuschek
Nina
N
Schmid
Martin G
MG
Kilár
Ferenc
F
Aboul-Enein
Hassan Y
HY
Gübitz
Gerald
G
D001565:Benzoates; D001581:Benzothiadiazines; D002219:Carbamates; D002482:Cellulose / Q000031:analogs & derivatives*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D004232:Diuretics; D004867:Equipment Design; D048448:Phenylcarbamates; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D049993:Sodium Chloride Symporter Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D017334:Teicoplanin
D001565:Benzoates; D001581:Benzothiadiazines; D002219:Carbamates; D004232:Diuretics; D048448:Phenylcarbamates; D049993:Sodium Chloride Symporter Inhibitors; C090722:tris(4-methylbenzoate)cellulose; C079151:cellulose trisphenylcarbamate; D017334:Teicoplanin; D002482:Cellulose