[Hemocoagulase in abdominal operation and its effect on hemoagglutination].
OBJECTIVE
To evaluate the hemostatic role of hemocoagulase in abdominal operation and its effects on coagulation.


METHODS
180 patients receiving abdominal operation were studied prospectively by randomized, double-blind controlled and multicenter design. They were divided into Hemocoagulase group (60 patients), lizhixue group (60), and manitol hexanitrate group (60). The groups were, observed in terms of the effects on hemostatic time, hemorrhagic volume, hemorrhagic volume per square unit, and body coagulation (BT, CT, PT, APTT and PLT) parameters.


RESULTS
The groups received different drugs. The average hemostatic time in the hemocoagulase group was 121.6 s, hemorrhagic volume was 9.6 g, and hemorrhagic volume per square unit was 0.2 g. The similar results were observed in the lizhixue group (P > 0.05), but they were significantly different (P < 0.05) from those of the manitol hexanitrate group (159.2 s, 12.49 g, 0.3 g). In the hemocoagulase and lizhixue groups hemorrhagic and hemoagglution time decreased 30 minutes and 1 day after operation. This finding was significantly differenct from that in the manitol hexanitrate group (P < 0.05).


CONCLUSIONS
Hemocoagulase plays a good hemostatic role in the hemorrhagic capillary at abdominal incision.
Zhu
Mingwei
M
Department of General Surgery, Beijing Hospital, Beijing 100730, China.
Cao
Jinduo
J
Jia
Zhengeng
Z
Duan
Zhiquan
Z
Liu
Guojin
G
Wei
Junmin
J
Long
Haikong
H
D000005:Abdomen; D000293:Adolescent; D000328:Adult; D000368:Aged; D012103:Batroxobin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D006490:Hemostatics; D012103:Batroxobin