title: Discrepant MR spectroscopic and perfusion imaging results in a case of malignant transformation of cerebral glioma.
abstract: We present serial MR perfusion and spectroscopic findings of a pathologically proved low grade glioma, which evolved into glioblastoma multiforme in 2 years in a 24-year-old man. The initial MR imaging studies, including enhanced conventional T1-weighted and perfusion imaging, were characteristic of a benign glioma with the only exception being that multi-voxel proton MR spectroscopy showed malignant features with a high choline:phosphocreatine ratio. Postoperative follow-up MR imaging revealed findings consistent with malignant glioma, with increased angiogenesis on perfusion images and heterogeneous enhancement on contrast-enhanced T1-weighted images that were further confirmed by second surgery. We suggest conducting close MR imaging follow-up of patients with glioma who have discrepant MR spectroscopic and perfusion results after treatment.
authors.affiliation: Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, Republic of China.
authors.forename: Wen-Chau
authors.initials: WC
authors.lastname: Wu
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Hsiao-Wen
authors.initials: HW
authors.lastname: Chung
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Juan
authors.forename: Chun-Jen
authors.initials: CJ
authors.lastname: Hsueh
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Gao
mesh_terms: D000328:Adult; D001810:Blood Volume / Q000502:physiology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D017352:Echo-Planar Imaging; D005910:Glioma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D014057:Tomography, X-Ray Computed
chemical_list: D011522:Protons