Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin.
Horinouchi
Masanori
M
Department of Hospital Pharmacy, School of Medicine, Kobe University, Japan.
Sakaeda
Toshiyuki
T
Nakamura
Tsutomu
T
Morita
Yoshinori
Y
Tamura
Takao
T
Aoyama
Nobuo
N
Kasuga
Masato
M
Okumura
Katsuhiko
K
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D004077:Digoxin / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004077:Digoxin