Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA.
We investigated a set of cell lines as to their sensitivity to proliferation inhibition, on the one side, and apoptosis induction, on the other, by the core histone deacetylase inhibitors butyrate and trichostatin A (TSA), respectively. The results can be summarized as follows: (i) the investigated cell lines can be classified into three groups of high, medium and low sensitivity to proliferation inhibition by the histone deacetylase inhibitors; (ii) there is no correlation between the sensitivities to proliferation inhibition and the sensitivities to apoptosis induction by the histone deacetylase inhibitors; (iii) a comparison of the relative sensitivities to butyrate versus TSA with regard to proliferation inhibition and apoptosis induction, respectively, revealed that besides a good correlation most often encountered, there are also cell lines with conspicuously differing relative sensitivities to the two structurally different histone deacetylase inhibitors.
Gálfi
Péter
P
Faculty of Veterinary Medicine, Institute of Physiology and Biochemistry, Szent-István University, Budapest, Hungary.
Neogrády
Zsuzsa
Z
Csordás
Adam
A
D017209:Apoptosis / Q000187:drug effects*; D002087:Butyrates / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005770:Gastrointestinal Neoplasms / Q000201:enzymology / Q000473:pathology*; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology / Q000473:pathology
D002087:Butyrates; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; C012589:trichostatin A