Effects of pregnancy-associated Listeria monocytogenes infection: necrotizing hepatitis due to impaired maternal immune response and significantly increased abortion rate.
The impact of L. monocytogenes infection on maternal immune responses as well as on the outcome of pregnancy was studied in a murine model of pregnancy-associated listeriosis. Mice infected i.v. with L. monocytogenes at day 15 of pregnancy showed a significantly impaired bacterial elimination, which resulted in a severe necrotizing hemorrhagic hepatitis. The aggravated course of the infection could be attributed to a suppressed transcription and production of anti-listerial, pro-inflammatory cytokines and chemokines, namely interferon-gamma, tumor necrosis factor, interleukin-12p40, inducible nitric oxide synthase, murine monokine induced by interferon-gamma, and interferon-gamma-inducible protein-10. In addition, listeriosis significantly increased the abortion rate. Infection of the placenta and fetuses was characterized by placental and fetal necrosis with unrestricted bacterial multiplication. A weak transcription of anti-listerial cytokines in the placenta in the absence of a cellular immune response could not prevent the fatal outcome of pregnancy-associated listeriosis.
Abram
Maja
M
Department of Microbiology, Medical Faculty, University of Rijeka, Rijeka, Croatia.
Schlüter
Dirk
D
Vuckovic
Darinka
D
Waber
Branka
B
Doric
Miljenko
M
Deckert
Martina
M
D000818:Animals; D018925:Chemokines / Q000096:biosynthesis / Q000235:genetics; D004195:Disease Models, Animal; D020964:Embryo Loss / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006520:Hepatitis, Animal / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D007111:Immunity, Cellular / Q000276:immunology*; D016867:Immunocompromised Host; D007124:Immunoenzyme Techniques; D008089:Listeria monocytogenes / Q000276:immunology* / Q000472:pathogenicity; D008088:Listeriosis / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D010920:Placenta / Q000382:microbiology / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018925:Chemokines; D012333:RNA, Messenger