title: Fluoride concentration in supragingival dental plaque after a single intake or habitual consumption of fluoridated milk.
abstract: The aim of this study was to evaluate the fluoride concentration in supragingival dental plaque after single and repeated intakes of fluoridated milk. The study group consisted of 22 schoolchildren, young adults and adults of both sexes, 8-41 years of age. After a 2-week fluoride depletion period and 3 days of plaque accumulation, 200 ml of fluoridated milk (1g F) was ingested along with a standardized lunch meal. Plaque samples were collected immediately before the intake and after 30, 120 and 240 min. From the adult participants (n = 9) additional samples were collected after 12 and 18 h. After a fluoride-free washout period of at least 2 weeks, the whole experimental procedure was repeated after 4 consecutive daily intakes of fluoridated milk. The fluoride concentration was determined after micro-diffusion with a fluoride selective electrode. The results showed a statistically significant 3-fold increase of the plaque fluoride levels up to 4 h after the intake. At 12 and 18 h after the intake, the recorded levels went gradually back to baseline. There was no significant difference between the fluoride concentrations in the supragingival plaque after the single intake compared with the repeated intakes. In conclusion, the findings support the suggestion that milk is a suitable vehicle for local fluoride administration into the oral cavity, also when consumed together with a meal.
authors.affiliation: Department of Odontology, Pediatric Dentistry, Umeå University, Sweden.
authors.forename: Kristina
authors.initials: K
authors.lastname: Engström
authors.forename: Lars G
authors.initials: LG
authors.lastname: Petersson
authors.forename: Svante
authors.initials: S
authors.lastname: Twetman
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000032:analysis*; D002648:Child; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000737:chemistry*; D004058:Diffusion; D004326:Drinking; D005247:Feeding Behavior; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D017736:Ion-Selective Electrodes; D008137:Longitudinal Studies; D008297:Male; D008892:Milk
chemical_list: D002327:Cariostatic Agents; D005459:Fluorides