title: Split-pool method for synthesis of solid-state material combinatorial libraries.
abstract: The synthesis and analysis of inorganic material combinatorial libraries by the split-pool bead method were demonstrated at the proof-of-concept level. Millimeter-size spherical beads of porous gamma-alumina, a commonly used support material for heterogeneous catalysts, were modified with Al(13)O(4)(OH)(24)(H(2)O)(12)(7+) cations in order to promote irreversible adsorption of the anionic fluorescent dyes Cascade Blue, Lucifer Yellow, and Sulforhodamine 101. The compositions of individual beads were easily determined through three split-pool cycles using a conventional fluorescence plate reader. Small split-pool material libraries were made by adsorbing noble metal salts (H(2)PtCl(6), H(2)IrCl(6), and RhCl(3)) into the beads. Analysis of these beads by micro-X-ray fluorescence showed that quantitative adsorption of metal salts without cross-contamination of beads could be achieved at levels (0.3 wt % metal loading) relevant to heterogeneous catalysis. The method offers the potential for synthesis of rather large libraries of inorganic materials through relatively simple benchtop split-pool chemistry.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, 16802, USA.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Sun
authors.forename: Benny C
authors.initials: BC
authors.lastname: Chan
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Ramnarayanan
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Leventry
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Mallouk
authors.forename: Simon R
authors.initials: SR
authors.lastname: Bare
authors.forename: Richard R
authors.initials: RR
authors.lastname: Willis