title: Cooperative host/guest interactions via counterion assisted chelation: pseudorotaxanes from supramolecular cryptands.
abstract: Addition of di- or tritopic hydrogen bond accepting anions to solutions of bis(5-hydroxymethyl-1,3-phenylene)-32-crown-10 and paraquat di(hexafluorophosphate) serves to enhance host/guest interaction. In particular, addition of Et4N+CF3COO- effectively boosts Ka 14-fold, as estimated by 1H NMR studies. Similar increases in apparent Ka values are observed upon addition of n-Bu4N+OTs-. Evidenced by crystal structures, the increased association results from chelation of the OH moieties of the crown by the di- or tritopic anions, forming supramolecular bicyclic macrocycles and stabilizing the complex in a cooperative manner.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212, USA.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Jones
authors.forename: Lev N
authors.initials: LN
authors.lastname: Zakharov
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold
authors.forename: Harry W
authors.initials: HW
authors.lastname: Gibson