title: Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions.
abstract: The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-0.1g/kg) significantly inhibited passive cutaneous anaphylaxis (PCA). The mast cell number was markedly decreased at the SPT-treated PCA site. In addition, SPT decreased intracellular calcium levels of activated mast cells. These results suggest that SPT inhibit the anaphylactic degranulation of mast cells through decrease of the intracellular calcium level.
authors.affiliation: College of Pharmacy, Wonkwang University, KI Co. Ltd., Iksan, Jeonbuk 570-749, South Korea.
authors.forename: Hyun Ja
authors.initials: HJ
authors.lastname: Jeong
authors.forename: Jin Mu
authors.initials: JM
authors.lastname: Yi
authors.forename: Seung Heon
authors.initials: SH
authors.lastname: Hong
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Kong
authors.forename: Kyung Suk
authors.initials: KS
authors.lastname: Kim
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Won
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Cho
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Shin
authors.forename: Ha Song
authors.initials: HS
authors.lastname: Kim
authors.forename: Hyung Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000707:Anaphylaxis / Q000276:immunology / Q000517:prevention & control*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects; D007723:Korea; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects / Q000276:immunology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine; D002118:Calcium