[Concomitant pulmonary nocardiosis and Hodgkin's disease: importance of long-term treatment].
A 32-year-old patient taking corticosteroid therapy for 10 months for autoimmune hemolytic anemia developed Hodgkin's disease and concomitant acute pulmonary nocardiosis. After treatment with imipenen and amikacin for 15 days, which was adapted to susceptibility tests, multiple-drug chemotherapy using the ABVD protocol (doxorubicin, bléomycin, vinblastine, dacarbazine) was given without recurrence of the pulmonary infection. Antibiotic prophylaxis using a minocycine-erythromycin combination was continued for 8 months. We discuss the importance of long-term treatment based on data in the literature.
Toudic
F
F
Service d'Hématologie Clinique, Hôpital Clemenceau, CHU, avenue G.-Clemenceau, 14033 Caen, France.
Reman
O
O
De Puyfontaine
O
O
Pan
B
B
Macro
M
M
Cheze
S
S
Leporrier
M
M
D000328:Adult; D000583:Amikacin / Q000008:administration & dosage; D000743:Anemia, Hemolytic / Q000150:complications / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004917:Erythromycin / Q000008:administration & dosage; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage; D008134:Long-Term Care; D008171:Lung Diseases / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008911:Minocycline / Q000008:administration & dosage; D009617:Nocardia Infections / Q000150:complications / Q000188:drug therapy*
D004917:Erythromycin; D015378:Imipenem; D000583:Amikacin; D008911:Minocycline