title: [Progressive course of multiple sclerosis].
abstract: The mechanisms of MS progression are now studied with great attention and the treatment strategies at this stage of MS are widely discussed. The clinical peculiarities, genetic profile, immunological and biochemical changes, data of pathomorphological and MRI studies are discussed in this review. The data of own original immunological, biochemical and MRI studies, comparing relapsing-remitting and progressive MS course are presented. The role of axonal degeneration in the disease progression and data of the last trial of beta-interferons in secondary progressive MS are also discussed.
authors.forename: I A
authors.initials: IA
authors.lastname: Zavalishin
authors.forename: M N
authors.initials: MN
authors.lastname: Zakharova
authors.forename: A V
authors.initials: AV
authors.lastname: Peresedova
authors.forename: L Sh
authors.initials: LSh
authors.lastname: Askarova
authors.forename: N I
authors.initials: NI
authors.lastname: Stoĭda
authors.forename: M V
authors.initials: MV
authors.lastname: Krotenkova
authors.forename: V G
authors.initials: VG
authors.lastname: Oleĭnikov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D001921:Brain / Q000473:pathology; D016207:Cytokines / Q000276:immunology; D018450:Disease Progression; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D020528:Multiple Sclerosis, Chronic Progressive / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D009410:Nerve Degeneration / Q000473:pathology; D009474:Neurons / Q000473:pathology; D012720:Severity of Illness Index; D013491:Suppressor Factors, Immunologic / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D013491:Suppressor Factors, Immunologic; D016899:Interferon-beta