title: Association of mannan-binding lectin deficiency with venous bypass graft occlusions in patients with coronary heart disease.
abstract: We investigated the effect of mannan-binding lectin (MBL) deficiency on the susceptibility to bypass graft occlusion in 62 patients with coronary heart disease. MBL deficiency appeared to be associated with occlusion (p = 0.0099). A high level of anti-cardiolipin IgG as well as the number of venous bypass grafts were also involved (p = 0.0018 and p = 0.0104, respectively). Since early occlusion (<5 years after surgery) of a venous bypass graft is considered to be caused by thrombosis or fibro-intimal hyperplasia superimposed by thrombosis, our finding also implies an association of MBL deficiency with thrombotic events. It remains unclear whether the previously confirmed effect of MBL deficiency in coronary disease is mediated through this possible thrombotic mechanism, or whether plaque formation is also involved in the process. Further studies are clearly warranted.
authors.affiliation: Department of Medicine, Tampere University Hospital, Tampere, Finland.
authors.forename: Vilho
authors.initials: V
authors.lastname: Limnell
authors.forename: Janne
authors.initials: J
authors.lastname: Aittoniemi
authors.forename: Outi
authors.initials: O
authors.lastname: Vaarala
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Seppo
authors.initials: S
authors.lastname: Laine
authors.forename: Vesa
authors.initials: V
authors.lastname: Virtanen
authors.forename: Timo
authors.initials: T
authors.lastname: Palosuo
authors.forename: Ari
authors.initials: A
authors.lastname: Miettinen
mesh_terms: D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000378:metabolism* / Q000601:surgery*; D004198:Disease Susceptibility / Q000276:immunology / Q000378:metabolism; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism; D016015:Logistic Models; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000172:deficiency*; D008875:Middle Aged; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D017153:Antibodies, Anticardiolipin; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007074:Immunoglobulin G; D037601:Mannose-Binding Lectin