The cellular and molecular basis of store-operated calcium entry.
The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals -- the activation of 'store-operated channels' (SOCs) -- remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.
Venkatachalam
Kartik
K
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
van Rossum
Damian B
DB
Patterson
Randen L
RL
Ma
Hong-Tao
HT
Gill
Donald L
DL
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004331:Drosophila melanogaster; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D013997:Time Factors
D002118:Calcium