Rapid synthesis of a glycosylphosphatidylinositol-based malaria vaccine using automated solid-phase oligosaccharide synthesis.
Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
Hewitt
Michael C
MC
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Snyder
Daniel A
DA
Seeberger
Peter H
PH
D002240:Carbohydrate Sequence; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis*; D017780:Malaria Vaccines / Q000138:chemical synthesis*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis*
D017261:Glycosylphosphatidylinositols; D017780:Malaria Vaccines; D009844:Oligosaccharides