Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) complexes of thiadiazole derived furanyl, thiophenyl and pyrrolyl Schiff bases.
2-Amino-1,3,4-thiadiazole undergoes a condensation reaction with furane-, thiophene- and pyrrole-2-carboxaldehyde to form tridentate NNO, NNS and NNN donor Schiff bases. These Schiff bases were further used to obtain complexes of the type [M(L)2]X, where M = Co(II), Cu(II), Ni(II) or Zn(II), L = L1, L2 or L3 and X = Cl2. The new compounds described here have been characterized by their physical, spectral and analytical data, and have been screened for antibacterial activity against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of the Schiff bases increased upon chelation/complexation in comparison to the uncomplexed Schiff bases against the tested bacterial species thus, opening new approaches to find new ways in the fight against antibiotic-resistant strains.
Chohan
Zahid H
ZH
Department of Chemistry, Islamia University, Bahawalpur, Pakistan.
Pervez
Humayun
H
Rauf
Abdul
A
Scozzafava
Andrea
A
Supuran
Claudiu T
CT
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003035:Cobalt / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009532:Nickel / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D005663:Furans; D011758:Pyrroles; D012545:Schiff Bases; D013830:Thiadiazoles; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc