The extracellular current blocking effect of cesium chloride on the theta wave in the rabbit hippocampal CA1 region.
We studied the extracellular effects of cesium chloride (CsCl), a blocker of the hyperpolarization-activated cationic current (I(h)), on the hippocampal theta wave in pentobarbital-anesthetized rabbits. We recorded spontaneous field potentials at the hippocampal CA1 region before and at three time periods after CsCl or saline injections. We found that CsCl injected into the apical dendritic layer attenuated the theta wave amplitude. CsCl affected neither the frequency nor the phase reversal of the theta wave between the apical and basal dendritic layers. Our findings indicate that I(h) in pyramidal neurons contributes to current generation of the limbic theta wave in vivo.
Kitayama
Masaomi
M
Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto,Ontario M5G 1X8, Canada. omisoul@hotmail.com
Taguchi
Tomoe
T
Miyata
Harue
H
Matsuda
Yoshiki
Y
Yamauchi
Toshio
T
Kogure
Shinichi
S
D000818:Animals; D002586:Cesium / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology*; D054815:Cyclic Nucleotide-Gated Cation Channels; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D008297:Male; D015221:Potassium Channels; D011817:Rabbits; D013826:Theta Rhythm / Q000187:drug effects*
D002712:Chlorides; D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D015221:Potassium Channels; D002586:Cesium; C028019:cesium chloride