title: Further important sensitizers in patients sensitive to fragrances.
abstract: The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series I). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM. 6.6% of 1855 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 41.1%, to series I and FM in 12.0% and to series I only in 7.2%. 74.3% of the 39 patients reacting to both FM and 1 of the materials of series I had any type of positive fragrance history, which was significantly higher in comparison to those with isolated reactions to series I (53.6% of 41), p = 0.04. The study identified further sensitizers relevant for patch testing of patients with contact dermatitis, of which Lyral is the most important single chemical.
authors.affiliation: Department of Dermatology, Klinikum Dortmund gGmbH and University of Witten/Herdecke, Dortmund, Germany.
authors.forename: P J
authors.initials: PJ
authors.lastname: Frosch
authors.forename: J D
authors.initials: JD
authors.lastname: Johansen
authors.forename: T
authors.initials: T
authors.lastname: Menné
authors.forename: C
authors.initials: C
authors.lastname: Pirker
authors.forename: S C
authors.initials: SC
authors.lastname: Rastogi
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.forename: A
authors.initials: A
authors.lastname: Goossens
authors.forename: J P
authors.initials: JP
authors.lastname: Lepoittevin
authors.forename: I R
authors.initials: IR
authors.lastname: White
mesh_terms: D000485:Allergens / Q000494:pharmacology; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000209:etiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000209:etiology*; D015994:Incidence; D007391:International Cooperation; D008297:Male; D010328:Patch Tests / Q000379:methods*; D010476:Perfume / Q000009:adverse effects*; D011159:Population Surveillance; D012307:Risk Factors; D012680:Sensitivity and Specificity; D023422:Skin Irritancy Tests
chemical_list: D000485:Allergens; D010476:Perfume