Long-term follow-up of cellular proliferation as a predictive index for the relapse of nasal polyposis.
BACKGROUND
The objective of this study was to identify a reproducible clinical parameter for predicting relapses of nasal polyposis after surgery.


METHODS
Ninety-three patients who had undergone ethmoidectomy of bilateral nasal polyps were followed for 3 years. Nasal polyps were obtained from all patients, and cellular suspensions were analyzed individually using flow cytometry. Based on the percentage of cells in the S phase, we identified three groups of patients (high, medium, and low percentages).


RESULTS
A relapse of nasal polyposis was observed in 15.00, 70.00, and 100.00% of patients from the low-, medium-, and high-percentage groups, respectively. Patients suffering relapses had a high percentage of cells in the S phase.


CONCLUSIONS
We identified two cutoff values for the percentage of cells in the S phase; above the first cutoff, some of the patients suffered relapses; above the second cut-off, all patients suffered relapses.
Bruno
Ernesto
E
Division of Otorhinolaryngology, Faculty of Medicine and Surgery, University of Rome Tor Vergata, Italy.
Mohamed
Ehab I
EI
Alessandrini
Marco
M
Russo
Sabino
S
Schiaroli
Stefania
S
De Lorenzo
Antonino
A
Di Girolamo
Alberto
A
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011237:Predictive Value of Tests; D016196:S Phase