title: In vitro corrosion behaviour and osteoblast response of thermally oxidised Ti6Al4V alloy.
abstract: In this work, the influence of thermal oxidation treatments of Ti6Al4V at 500 degrees C and 700 degrees C for 1 h on the in vitro corrosion behaviour and osteoblast response is studied. The potential of these treatments, aimed to improve the wear surface performance as biomaterial, relies in the formation of an outer "ceramic" layer of rutile. The corrosion behaviour was evaluated in simulated human fluids by electrochemical impedance spectroscopy and anodic polarisation tests. The effect of these thermal oxidation treatments on osteoblastic behaviour was studied in primary cultures of human osteoblastic cells. Results show that thermal oxidation treatments do not decrease the high in vitro corrosion resistance of the Ti6Al4V alloy. Osteoblast adhesion studies indicate that thermal oxidation treatments do not impair the material biocompatibility. Moreover, the thermal oxidation at 700 degrees C enhances the in vitro osteoblastic cell attachment compared to the thermal oxidation at 500 degrees C.
authors.affiliation: Centro Nacional de Investigaciones Metalúrgicas, CENIM-CSIC, Avda Gregorio del Amo 8, Madrid 28040, Spain. crisga@cenim.csic.es
authors.forename: M C
authors.initials: MC
authors.lastname: García-Alonso
authors.forename: L
authors.initials: L
authors.lastname: Saldaña
authors.forename: G
authors.initials: G
authors.lastname: Vallés
authors.forename: J L
authors.initials: JL
authors.lastname: González-Carrasco
authors.forename: J
authors.initials: J
authors.lastname: González-Cabrero
authors.forename: M E
authors.initials: ME
authors.lastname: Martínez
authors.forename: E
authors.initials: E
authors.lastname: Gil-Garay
authors.forename: L
authors.initials: L
authors.lastname: Munuera
mesh_terms: D000497:Alloys / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002478:Cells, Cultured; D003343:Corrosion; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology; D010084:Oxidation-Reduction; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C031462:titanium alloy (TiAl6V4); D014025:Titanium