title: Lymphocyte traffic in lymphoid organ neogenesis: differential roles of Ltalpha and LTalphabeta.
abstract: In these studies the differential roles of LTalpha and LTalphabeta complex have been discussed with regard to development of lymphoid organs in ontogeny and in inflammation, LTalpha is necessary for PLNand MLN, most likely as both LTalpha and LTalphabeta complex, whereas only LTalphabeta is required for MLN. Both are involved in the cellularity of the NALT. When expressed as a transgene, LTa alone can induce cellular accumulation and MAdCAM, but not PNAd, an epitope associated with PLN HEV. These data suggest that LTalphabeta complex plays a crucial role in PNAd. One hypothesis is that LTalphabeta induces PNAd through modification via an HEV sulfotransferase. RIPLTalpha.RIPLTbeta mice will provide an important tool to investigate this question.
authors.affiliation: Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Danielle L
authors.initials: DL
authors.lastname: Drayton
authors.forename: Kee
authors.initials: K
authors.lastname: Chan
authors.forename: Werner
authors.initials: W
authors.lastname: Lesslauer
authors.forename: Jason
authors.initials: J
authors.lastname: Lee
authors.forename: Xiao Yan
authors.initials: XY
authors.lastname: Ying
authors.forename: Nancy H
authors.initials: NH
authors.lastname: Ruddle
mesh_terms: D000818:Animals; D006801:Humans; D008221:Lymphoid Tissue / Q000196:embryology / Q000254:growth & development / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000276:immunology*; D053308:Lymphotoxin-beta; D008565:Membrane Proteins / Q000276:immunology*; D038081:Organogenesis / Q000276:immunology
chemical_list: C505886:LTB protein, human; D008233:Lymphotoxin-alpha; D053308:Lymphotoxin-beta; D008565:Membrane Proteins