[Vitamin E status in hypercholesterolemic children].
The prime role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis is almost universally accepted. Fat soluble antioxidant vitamin E associated with lipoproteins, appears to have antiatheroma properties. In the presented studies concentration of vitamin E and the relationship between tocopherol and lipids were studied in blood of hypercholesterolemic children. Level of vitamin E was determined by high-performance liquid chromatography (HPLC) method. Compared with normocholesterolemic children, hypercholesterolemic patients had a significantly lower red blood cell vitamin E content (2.55 +/- 0.19 micromol/l vs 3.15+/- 0.33 micromol/l; p<0.005) in spite of their higher plasma vitamin E concentration (27.9 +/- 8.3 micromol/l vs 21.01 +/- 3.6 micromol/l; pl;0.001). In the group of patient tocopherol-to-total cholesterol and tocopherol-to-lipids ratio was statistically lower compared to those in the control group. In hypecholesterolemic children vitamin E positively correlated with total cholesterol (r=0.43; p<0.02), LDL-C (low-density lipoprotein cholesterol) (r=0.42; p<0.02) and lipids (triglycerides + total cholesterol) (r=0.45; p<0.02). This study demonstrates that total plasma vitamin E concentration is not a suitable predictor of cell vitamin E status. Our results suggested that the tocopherol of erythrocytes and vitamin E to lipids ratio in plasma, could be more meaningful indicators to evaluate the vitamin E status in hypercholesterolemic children.
Chelchowska
Magdalena
M
Zaklad Biochemii i Diagnostyki Laboratoryjnej, Instytut Matki i Dziecka, ul. Kasprzaka 17a, Warszawa, Poland. imid@imid.med.pl
Laskowska-Klita
Teresa
T
Radomyska
Barbara
B
D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000097:blood*
D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D014810:Vitamin E