title: [Compliance, efficacy and quality of life].
abstract: Compliance is the appropriateness of patient behaviour to therapeutic prescriptions. Good compliance increases treatment efficacy although its constraints may harm quality of life. Factors affecting compliance are related to the patient, the disease, health-care workers, family and treatment itself. Psycho-sociologic theories have attempted to explain patient behaviour. In clinical trials, compliance has to be optimized, i.e. in the protocol, during the study and the statistical analysis. In real life, compliance concerns all those involved in health-care, particularly for education, training and motivation of the patients and their immediate environment. Observational surveys relating to compliance are needed to determine prioriites and to develop a "compliance approach" based on improving information and the use of tools for better therapeutic adherence. Evaluation of the quality of life and patient satisfaction aspects is necessary to validate this approach.
authors.affiliation: Service de Médecine Interne, Hôpital Lariboisière, Paris, France. jf.bergmann@lrb.ap-hop-paris.fr
authors.forename: J F
authors.initials: JF
authors.lastname: Bergmann
authors.forename: E
authors.initials: E
authors.lastname: Dohin
authors.forename: Y
authors.initials: Y
authors.lastname: Juillet
mesh_terms: D004358:Drug Therapy; D006184:Habits; D015233:Models, Statistical; D010349:Patient Compliance / Q000523:psychology / Q000706:statistics & numerical data*; D017060:Patient Satisfaction; D011788:Quality of Life / Q000523:psychology*; D012107:Research Design