Portrait of a stem cell.
There is great enthusiasm for the potential use of stem cells in treating tissue degenerative disorders, but little is known about the intrinsic molecular programs defining self-renewal and differentiation. New data sets produced by transcriptional profiling of purified stem cell populations begin to establish the nature of "stemness."
Burns
Caroline Erter
CE
Department of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital of Boston, 320 Longwood Avenue, Enders 650, Boston, MA 02115, USA.
Zon
Leonard I
LI
D000818:Animals; D002454:Cell Differentiation; D015870:Gene Expression; D020869:Gene Expression Profiling; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*