[ANCA associated glomerulonephritis related to benzylthiouracil].
BACKGROUND
Vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) have been reported in patients suffering from Graves' disease treated with anti-thyroid drugs and especially propylthiouracil (PTU).


METHODS
We report a case of Graves' disease treated with benzylthiouracil (Basdène). This therapy was complicated by acute renal insufficiency due to crescentic glomerulonephritis associated with pANCA. After benzylthiouracil withdrawal and under corticosteroids, renal insufficiency, biological inflammation and pANCA levels decreased.


CONCLUSIONS
Similar vasculitis associated with pANCA secondary to anti-thyroid drugs, especially propylthiouracil, were described. This suggests a causal relation between drug and vasculitis. To our best knowledge, it is the first case of vasculitis secondary to benzylthiouracil.
Tieulie
N
N
Service de médecine interne, groupe hospitalier Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75651 Paris, France.
Huong
Du Le Thi
DL
Andreu
M
M
Wechsler
B
B
Mercadal
L
L
Beaufils
H
H
Diermert
M C
MC
Piette
J C
JC
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013889:Thiouracil / Q000009:adverse effects* / Q000031:analogs & derivatives*; D014543:Uridine Phosphorylase / Q000037:antagonists & inhibitors*; D014657:Vasculitis / Q000139:chemically induced
D019268:Antibodies, Antineutrophil Cytoplasmic; D013889:Thiouracil; D014543:Uridine Phosphorylase; C019269:benzylthiouracil