Synthesis of natural beta-D-(1-->3)-glucopyranosyl oligosaccharides.
beta-D-(1-->3)-Glucan core structure derivatives corresponding to schizophyllan, epiglucan and lentinan were synthesized efficiently. 4,6-O-Benzylidenated glucopyranosyl acceptors were found to be helpful in the attempted beta-D-(1-->3) bond formation. The epiglucan pentasaccharide showed a weak anti-tumor activity in preliminary mice tests.
He
Hongmei
H
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, Beijing 100085, PR China.
Yang
Feng
F
Du
Yuguo
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000737:chemistry; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry* / Q000494:pharmacology; D009904:Optical Rotation; D012509:Sarcoma / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
D000970:Antineoplastic Agents; D001597:Benzylidene Compounds; D009844:Oligosaccharides