Molecular basis of inherited predispositions for tumors.
On the basis of literature data and own experience the authors review the current knowledge about the molecular basis of inherited predispositions for tumors. They hypothesize that in the near perspective 5-10 years studies using existing registry data/material and the latest novel technology will allow the identification of the molecular background for the majority of hereditary cancers which will have enormous practical consequences especially for the prevention of malignancies.
Lubiński
Jan
J
Department of Genetics and Pathology, Pomeranian Academy of Medicine, Szczecin, Poland.
Górski
Bohdan
B
Kurzawski
Grzegorz
G
Jakubowska
Anna
A
Cybulski
Cezary
C
Suchy
Janina
J
Debniak
Tadeusz
T
Grabowska
Ewa
E
Lener
Marcin
M
Nej
Katarzyna
K
D020137:Base Pair Mismatch / Q000235:genetics; D004252:DNA Mutational Analysis; D004260:DNA Repair / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree