title: L-DOPA oxidation products prevent H2O2-induced oxidative damage to cellular DNA.
abstract: Using the single-cell gel electrophoresis ("Comet") assay, we show that tyrosinase-generated L-DOPA oxidation products prevent H2O2-induced oxidative DNA damage in cultured tissue cells. We propose that these oxidation products trigger cellular processes that up-regulate the overall antioxidant status of the cell, and could be incorporated into treatments of pathological conditions associated with elevated oxidative DNA damage and other manifestations of increased oxidative stress.
authors.affiliation: Department of Biology, The Chinese University of Hong Kong, SAR, Hong Kong, China.
authors.forename: Yu-ling
authors.initials: YL
authors.lastname: Shi
authors.forename: Iris F F
authors.initials: IF
authors.lastname: Benzie
authors.forename: John A
authors.initials: JA
authors.lastname: Buswell
mesh_terms: D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007980:Levodopa / Q000378:metabolism*; D016877:Oxidants / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014407:Tumor Cells, Cultured
chemical_list: D016877:Oxidants; D007980:Levodopa; D006861:Hydrogen Peroxide