title: [Autonomic nervous system function and effects of beta-adrenoblockers on heart rhythm variability in patients with myocardial infarction].
abstract: Heart rhythm variability on myocardial infarction (MI) day 1, 3, 7 and 11 was assessed mathematically to study function of the autonomic nervous system in 101 MI patients. The initial autonomic tonicity (IAT), autonomic reactivity (AR) and autonomic maintenance (AM) were studied. Depending on the site of the infarction in the myocardium, different type of autonomic homeostasis were identified. Moderate sympathicotonia, sympathicotonic type of AR and adequate AM irrespective of IM location were found most favourable in relation to the MI course and prognosis. The spectral analysis of the heart rhythm showed a significant shift of the frequency spectrum in the inferior MI to high frequencies and in anterior MI--to low frequencies. Autonomic dysfunction score is higher in the anterior MI. Psychoemotional state of the patients was determined by Spilberg-Khanin test evaluating reactive and personality anxieties. These characteristics were moderate and high in patients with MI and effort angina, respectively. The study of selective beta-adrenoblockers effect on heart rhythm variability proved that lokren (betaxolol) in a dose of 10 mg/day significantly and positively influences heart rhythm and objective status of the patients. Less effective is betacard (atenolol). Nebivolol is not indicated in acute MI. Significant correlations are found between the findings of IAT mathematical analysis, psychoemotional features of the patients and complications of MI. Parameters of an unfavourable course and outcome of MI are described.
authors.forename: I A
authors.initials: IA
authors.lastname: Latfullin
authors.forename: G P
authors.initials: GP
authors.lastname: Ishmurzin
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D015784:Betaxolol / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D005260:Female; D005583:Fourier Analysis; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000523:psychology; D010551:Personality
chemical_list: D000319:Adrenergic beta-Antagonists; D015784:Betaxolol