title: [Relapse of Creosote poisoning: report of a case taking Seirogan tablets].
abstract: A thirty-eight year old man took about 180 tablets of Seirogan. He was unconscious and had dyspnea with dark brown urine on admission. He recovered gradually after initial treatment. Seirogan contains a phenolic component. Symptoms and signs of poisoning are unconsciousness, convulsion, digestive tract disorder, pulmonary edema, hepatic failure, renal failure, and miosis. Clinical features include dark brown urine. On day 7, he again showed signs of creosote poisoning: relapse of unconsciousness and dark colored urine. Plasma concentration of phenol determined on the day before the relapse was much higher than that expected from the half-life of blood phenol. It is reported that Creosote poisoning results in a decrease in the intestinal peristalsis, or paralytic ileus. We would like to emphasize that a relapse of Creosote poisoning may occur due to possible delayed absorption of the Seirogan tablets.
authors.affiliation: Department of Emergency and Critical Care Medicine, Kansai Medical University.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kajimoto
authors.forename: Takaya
authors.initials: T
authors.lastname: Tanaka
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hirakawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shinya
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsuo
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakatani
mesh_terms: D000208:Acute Disease; D000328:Adult; D000930:Antidiarrheals / Q000737:chemistry / Q000506:poisoning*; D003407:Creosote / Q000493:pharmacokinetics / Q000506:poisoning*; D006207:Half-Life; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000737:chemistry / Q000506:poisoning*; D010528:Peristalsis / Q000187:drug effects; D012008:Recurrence; D013607:Tablets; D013997:Time Factors
chemical_list: D000930:Antidiarrheals; D004366:Nonprescription Drugs; D013607:Tablets; D003407:Creosote