title: [High-risk human papilloma virus and cervical intraepithelial neoplasia in women at 2 hospitals in Mexico City].
abstract: OBJECTIVE
  To determine the high risk HPV (HR-HPV) association with Cervical Intraepithelial Neoplasia (CIN) in women of two Dysplasia Clinics in Mexico City.
  
  
  METHODS
  Prolective case-control study was done. Women with and without security affiliation attended in Instituto Mexicano del Seguro Social (Hospital 1) and Hospital General de México (Hospital 2) were included in the study. Cases were women with histopathologic diagnosis of CIN and controls were women with negative dysplasia in cytologic study (Pap). Information was obtained by direct interview. HR-HPV was determined by Hybrid Capture II assay, in cervical samples. Bivariate and logistic regression analysis was done.
  
  
  RESULTS
  One hundred and two cases and 192 controls from Hospital 1 and 89 cases and 66 controls from Hospital 2 were included. 83.3% and 77.3% of women from Hospital 1 and 2 respectively were positive to HR-HPV. The association HR-HPV and CIN in Hospital 1 was ORa = 40.6, C.I. 95% = 17-96.8; while in Hospital 2 there was not association. Age was an effect modifier in the HR-HVP and CIN association, in Hospital 1. It was observed a correlation between viral load and CIN degree.
  
  
  CONCLUSIONS
  The HR-HPV infection frequency in controls and CIN I was higher than the reported in other studies. Age was a modifier in the HR-HPV association and CIN. In dysplasia clinics without medical referral system of patients is possible to observe similar risk factors to cervical cancer.
authors.affiliation: Unidad de Investigación Médica en Enfermedades Oncológicas, Servicio de Patología, Hospital de Oncología, CMN Siglo XXI, IMSS. dulcema@servidor.unam.mx
authors.forename: Dulce Ma
authors.initials: DM
authors.lastname: Hernández-Hernández
authors.forename: Alejandro
authors.initials: A
authors.lastname: García-Carrancá
authors.forename: Miriam C
authors.initials: MC
authors.lastname: Guido-Jiménez
authors.forename: José Luis
authors.initials: JL
authors.lastname: González-Sánchez
authors.forename: Fernando
authors.initials: F
authors.lastname: Cruz-Talonia
authors.forename: Teresa
authors.initials: T
authors.lastname: Apresa-García
authors.forename: Olga A
authors.initials: OA
authors.lastname: Martínez-Elizondo
authors.forename: Laura
authors.initials: L
authors.lastname: Ornelas-Bernal
authors.forename: Isabel
authors.initials: I
authors.lastname: Alvarado-Cabrera
authors.forename: Sergio
authors.initials: S
authors.lastname: Muñoz
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006769:Hospitals, General; D006779:Hospitals, Public; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D017584:Reproductive History; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014505:Urban Population; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000821:virology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D014774:Virulence
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral