title: Clinical assessment of neoadjuvant chemotherapy and interval cytoreductive surgery for unresectable advanced ovarian cancer.
abstract: Sixty-five patients with unresectable advanced epithelial ovarian cancer who underwent exploratory laparotomy or unilateral oophorectomy were reviewed. Forty-five of 65 patients received 3.8 cycles of neoadjuvant chemotherapy (NAC) and were successfully debulked at interval cytoreductive surgery (IRS); 31 of 45 showed no evidence of disease. Patients with residuals <1 cm at IRS had a high possibility of achieving clinical remission. Patients who failed to receive IRS showed poor prognosis. Also, 63 patients who underwent conventional primary debulking surgery with residuals >1 cm were investigated as a contrast. No significant difference was observed in patient survival between the NAC group and the conventional treatment group. NAC and IRS offered patients with unresectable tumors survival similar to that of those with suboptimally resectable tumors at primary debulking. We conclude that this strategy has potential benefits for the patients with clinically aggressive ovarian cancer who are unable to receive standard treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Kurume University School of Medicine, Japan. kimi@med.kurume-u.ac.jp
authors.forename: Kimio
authors.initials: K
authors.lastname: Ushijima
authors.forename: Syun-ichiro
authors.initials: S
authors.lastname: Ota
authors.forename: Kan
authors.initials: K
authors.lastname: Komai
authors.forename: Go
authors.initials: G
authors.lastname: Matsuo
authors.forename: Sigenobu
authors.initials: S
authors.lastname: Motoshima
authors.forename: Shizue
authors.initials: S
authors.lastname: Honda
authors.forename: Renpei
authors.initials: R
authors.lastname: Tomonari
authors.forename: Toru
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kamura
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018269:Carcinoma, Endometrioid / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D010052:Ovariectomy; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents