Pecam-1 expression in patients with relapsing-remitting multiple sclerosis.
PECAM-1 is an adhesion molecule--a member of the immunoglobulin superfamily--involved in the transendothelial migration of leukocytes. PECAM-1 is expressed on lymphocytes, monocytes and granulocytes. It is also found on endothelial cells and platelets. We present data showing that the cell-bound form of PECAM-1 expression on monocytes is increased in MS patients, compared to controls. We also show that PECAM-1 is significantly over-expressed on lymphocytes in patients with active MRI lesions, when compared to those without gadolinium-enhancing lesions. Our results suggest that the cell-bound form of PECAM-1 can be regarded as a marker of MS activity.
Niezgoda
Adam
A
Department of Clinical Neuroimmunology, University School of Medicine, Poznań, Poland. adamniezgoda@wp.pl
Losy
Jacek
J
D000328:Adult; D015415:Biomarkers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*
D015415:Biomarkers; D019408:Platelet Endothelial Cell Adhesion Molecule-1