Hostility, the metabolic syndrome, and incident coronary heart disease.
This invesgation examined the impact of hostility and the metabolic syndrome on coronary heart disease (CHD) using prospective data from the Normative Aging Study. Seven hundred seventy-four older, unmedicated men free of cardiovascular disease were included in the study. The total Cook-Medley Hostility (Ho) Scale score, anthropometric data, serum lipids, fasting insulin concentrations, blood pressure, cigarette smoking, alcohol consumption, and total dietary calories were used to predict incident CHD during a 3-year follow-up interval. Multivariate analysis indicated that only Ho positively predicted and high-density lipoprotein cholesterol level negatively predicted incident CHD. Ho's effects on CHD may be mediated though mechanisms other than factors that constitute the metabolic syndrome.
Niaura
Raymond
R
Department of Psychiatry and Human Behavior, Brown Medical School, Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, Rhode Island 02903, USA. raymond_niaura@brown.edu
Todaro
John F
JF
Stroud
Laura
L
Spiro
Avron
A
Ward
Kenneth D
KD
Weiss
Scott
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001900:Boston / Q000453:epidemiology; D003327:Coronary Disease / Q000453:epidemiology*; D006791:Hostility; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000523:psychology*; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors