title: Finding signals that regulate alternative splicing in the post-genomic era.
abstract: Alternative splicing of pre-mRNAs is central to the generation of diversity from the relatively small number of genes in metazoan genomes. Auxiliary cis elements and trans-acting factors are required for the recognition of constitutive and alternatively spliced exons and their inclusion in pre-mRNA. Here, we discuss the regulatory elements that direct alternative splicing and how genome-wide analyses can aid in their identification.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. tcooper@bcm.tmc.edu
authors.forename: Andrea N
authors.initials: AN
authors.lastname: Ladd
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Cooper
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D019295:Computational Biology; D004742:Enhancer Elements, Genetic / Q000235:genetics; D005544:Forecasting; D005786:Gene Expression Regulation / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D012322:RNA Precursors / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics
chemical_list: D012322:RNA Precursors; D015534:Trans-Activators