Disposition and metabolism of isoeugenol in the male Fischer 344 rat.
The primary objective of these studies was to determine the absorption, distribution, metabolism and excretion of isoeugenol following oral and intravenous administration to male Fischer-344 rats. Following a single oral dose of [14C]isoeugenol (156 mg/kg, 50 microCi/kg), greater than 85% of the administered dose was excreted in the urine predominantly as sulfate or glucuronide metabolites by 72 h. Approximately 10% was recovered in the feces, and less than 0.1% was recovered as CO(2) or expired organics. No parent isoeugenol was detected in the blood at any of the time points analyzed. Following iv administration (15.6 mg/kg, 100 microCi/kg), isoeugenol disappeared rapidly from the blood. The t(1/2) was 12 min and the Cl(s) was 1.9 l/min/kg. Excretion characteristics were similar to those of oral administration. The total amount of radioactivity remaining in selected tissues by 72 h was less than 0.25% of the dose following either oral or intravenous administration. Results of these studies show that isoeugenol is rapidly metabolized and is excreted predominantly in the urine as phase II conjugates of the parent compound.
Badger
D A
DA
Department of Pharmacology and Toxicology and Center for Toxicology, The University of Arizona, 1501 N. Campbell Ave., Tucson 85721, USA.
Smith
R L
RL
Bao
J
J
Kuester
R K
RK
Sipes
I G
IG
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005054:Eugenol / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D005054:Eugenol; C036643:isoeugenol