title: Elevation of IL-6 in ATL patient with a pathological fracture.
abstract: Hypercalcemia and osteolytic bone lesion are important complications in the prognosis of patients with adult T cell leukemia/lymphoma (ATL). We report a 61-year-old Japanese woman who died of ATL and had multiple osteolytic lesions and pathological fractures of her extremities. Highly increased serum levels of Interleukin-6 (IL-6) and a parathyroid hormone-related protein (PTHrP) together with a high level of serum calcium observed at the time of fractures suggested their contribution to the formation of the bone lesions.
authors.affiliation: Department of Dermatology, Oita Medical University, Hasama-machi, Japan.
authors.forename: Saburo
authors.initials: S
authors.lastname: Anzai
authors.forename: Susumu
authors.initials: S
authors.lastname: Takayasu
authors.forename: Sakuhei
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Masamichi
authors.initials: M
authors.lastname: Tateyama
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Taira
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takashita
mesh_terms: D001842:Bone and Bones / Q000473:pathology; D002118:Calcium / Q000097:blood; D005260:Female; D005264:Femoral Fractures / Q000097:blood / Q000209:etiology; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006810:Humeral Fractures / Q000097:blood / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D010014:Osteolysis / Q000097:blood / Q000209:etiology / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones / Q000097:blood; D011859:Radiography
chemical_list: D015850:Interleukin-6; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones; D002118:Calcium