title: Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals.
abstract: We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.
authors.affiliation: IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain. javiermp@ns.hubtip.scs.es
authors.forename: Javier
authors.initials: J
authors.lastname: Martinez-Picado
authors.forename: Simon D W
authors.initials: SD
authors.lastname: Frost
authors.forename: Nuria
authors.initials: N
authors.lastname: Izquierdo
authors.forename: K
authors.initials: K
authors.lastname: Morales-Lopetegi
authors.forename: Silvia
authors.initials: S
authors.lastname: Marfil
authors.forename: Teresa
authors.initials: T
authors.lastname: Puig
authors.forename: Cecilia
authors.initials: C
authors.lastname: Cabrera
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
authors.forename: Lidia
authors.initials: L
authors.lastname: Ruiz
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000235:genetics; D023241:Antiretroviral Therapy, Highly Active; D001483:Base Sequence; D019143:Evolution, Molecular; D015752:Genes, env; D014644:Genetic Variation; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000097:blood / Q000235:genetics
chemical_list: D000956:Antigens, Viral; D012367:RNA, Viral