One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT.
A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.
Sun
Xiao Bin
XB
Key Laboratory of Bio-organic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084, China.
Kang
Jian Xun
JX
Zhao
Yu Fen
YF
D019380:Anti-HIV Agents / Q000138:chemical synthesis; D006801:Humans; D063065:Organophosphonates / Q000138:chemical synthesis; D011355:Prodrugs / Q000138:chemical synthesis*; D018119:Stavudine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis*
D019380:Anti-HIV Agents; D063065:Organophosphonates; D011355:Prodrugs; D015215:Zidovudine; D018119:Stavudine