title: Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wistar rats.
abstract: Chronic fructose treatment in rats has repeatedly been shown to elevate blood pressure in association with insulin resistance and hyperinsulinemia. The purpose of the current study was to investigate the effect of the leaf methanol extract of Bidens pilosa on systolic blood pressure (SBP) and plasma glucose, insulin, cholesterol, triglycerides and creatinine levels in rats with fructose-induced hypertension. Wistar rats that drank a 10% fructose solution for 3-6 weeks showed significant increase not only in plasma insulin and cholesterol levels but also in SBP. B. pilosa extract was able to prevent the establishment of hypertension and lower elevated blood pressure levels. The extract also reduced the highly elevated plasma insulin levels provoked by the high fructose diet. These results suggest that the leaf methanol extract of B. pilosa exerts its antihypertensive effect in part by improving insulin sensitivity.
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Théophile
authors.initials: T
authors.lastname: Dimo
authors.forename: Silvere V
authors.initials: SV
authors.lastname: Rakotonirina
authors.forename: Paul V
authors.initials: PV
authors.lastname: Tan
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Azay
authors.forename: Etienne
authors.initials: E
authors.lastname: Dongo
authors.forename: Gérard
authors.initials: G
authors.lastname: Cros
mesh_terms: D000818:Animals; D031176:Bidens; D001786:Blood Glucose / Q000032:analysis; D005632:Fructose / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy / Q000517:prevention & control*; D015228:Hypertriglyceridemia / Q000209:etiology; D008297:Male; D000432:Methanol; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D013599:Systole / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D005632:Fructose; D000432:Methanol