Genetic alterations associated with adult diffuse astrocytic tumors.
Astrocytic tumors make up a wide range of neoplasms that differ in their location in the central nervous system, morphologic features, progressive and invasive behaviors, and the age and gender of people they affect. This report reviews the cytogenetic, molecular cytogenetic, and molecular genetic abnormalities associated with diffuse infiltrating astrocytomas in adults. This group of tumors is subdivided into low-grade astrocytomas (WHO grade II), anaplastic astrocytomas (WHO grade III), and glioblastoma multiforme (WHO grade IV).
Shapiro
Joan Rankin
JR
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA. jshapiro@chw.edu
D000782:Aneuploidy; D001254:Astrocytoma / Q000235:genetics*; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D016158:Genes, p53; D005909:Glioblastoma / Q000235:genetics; D006801:Humans; D009154:Mutation; D012730:Sex Chromosomes