title: Dyskinesia after fetal cell transplantation for parkinsonism: a PET study.
abstract: Persistent dyskinesias in the absence of or with only minimal amounts of dopaminergic medication have been reported after dopamine cell implantation for Parkinson's disease. In this study, we used [(18)F]fluorodopa (FDOPA) and positron emission tomography to determine whether this complication resulted from specific alterations in dopamine function after transplantation. Caudate and putamen FDOPA uptake values in these patients (DYS+, n = 5) were compared with those obtained in a cohort of age- and disease duration-matched transplant recipients who did not develop this complication (DYS-, n = 12). PET signal for both groups was compared at baseline and at 12 and 24 months after transplantation. We found that putamen FDOPA uptake was significantly increased (p < 0.005) in DYS+ transplant recipients. These increases were predominantly localized to two zones within the left putamen. In addition to the posterodorsal zone in which a prominent reduction in FDOPA uptake was present at baseline, the DYS+ group also displayed a relative increase ventrally, in which preoperative dopaminergic input was relatively preserved. Postoperative FDOPA uptake did not reach supranormal values over the 24-month follow-up period. These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism.
authors.affiliation: Center for Neurosciences, North Shore Long Island Jewish Research Institute and Department of Neurology, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.forename: Andrew
authors.initials: A
authors.lastname: Feigin
authors.forename: Vijay
authors.initials: V
authors.lastname: Dhawan
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukuda
authors.forename: Qiuhu
authors.initials: Q
authors.lastname: Shi
authors.forename: Paul
authors.initials: P
authors.lastname: Greene
authors.forename: Robert
authors.initials: R
authors.lastname: Breeze
authors.forename: Stanley
authors.initials: S
authors.lastname: Fahn
authors.forename: Curt
authors.initials: C
authors.lastname: Freed
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
mesh_terms: D000328:Adult; D001921:Brain / Q000196:embryology; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000378:metabolism; D015331:Cohort Studies; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004311:Double-Blind Method; D020820:Dyskinesias / Q000209:etiology*; D016332:Fetal Tissue Transplantation / Q000009:adverse effects*; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000601:surgery*; D011699:Putamen / Q000000981:diagnostic imaging / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine