Atherothrombotic risk factors in subjects with a family history of stroke.
BACKGROUND
Subjects with stroke in a first-degree relative are at increased risk of atherothrombotic vascular disease. We aimed to examine atherothrombotic risk factors in such a population.


METHODS
145 subjects with a first-degree relative with stroke and 143 controls were recruited. Measurements were made of features of the insulin resistance syndrome, haemostatic and fibrinolytic risk factors, and glucose tolerance tests.


RESULTS
The relatives had higher systolic blood pressure, HDL, 2-hour glucose, factor VII:C, fibrinogen, vWF and more had smoked. Differences remained in factor VII:C, systolic BP and 2-hour glucose after adjustment.


CONCLUSIONS
This population demonstrates adverse thrombotic risk factors and increased FVII:C activity may contribute to increased cardiovascular risk.
Lansbury
Alastair J
AJ
Academic Unit of Molecular Vascular Medicine, The Research School of Medicine, University of Leeds, UK. alastair@lanners.fsnet.co.uk
Grant
Peter J
PJ
Catto
Andrew J
AJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000209:etiology*; D005167:Factor VII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008499:Medical Records; D024821:Metabolic Syndrome / Q000503:physiopathology; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*; D013927:Thrombosis / Q000209:etiology*; D014841:von Willebrand Factor / Q000032:analysis
D014841:von Willebrand Factor; D005167:Factor VII; D005340:Fibrinogen