One-pot synthesis of 2,4-benzodiazepin-1-ones using benzotriazole methodology.
2, 4-Benzodiazepin-1-ones were prepared in moderate to good yields by reaction of bis(benzotriazolylmethyl)amines with ortho-metalated N-substituted benzamides.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. Katritzky@chem.ufl.edu
Nair
Satheesh K
SK
Rodriguez-Garcia
Valerie
V
Xu
Yong-Jiang
YJ
D000588:Amines / Q000737:chemistry; D001570:Benzodiazepinones / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical; D014230:Triazoles / Q000737:chemistry
D000588:Amines; D001570:Benzodiazepinones; D014230:Triazoles; C012771:benzotriazole