Transition metal acetylsalicylates and their anti-inflammatory activity.
Mononuclear and binuclear transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] acetylsalicylates of the type [M(L)2], [M(L)2Cl2] and [(M)2(L)4] have been prepared and characterized on the basis of their physical, spectral and analytical data. The complexes have been investigated in an in vivo animal model for anti-inflammatory activity and show a better effect and a more potent action than acetylsalicylic acid.
Chohan
Zahid H
ZH
Department of Chemistry, Islamia University, Bahawalpur, Pakistan.
Iqbal
Mohammad S
MS
Iqbal
Hummara Sadia
HS
Scozzafava
Andrea
A
Supuran
Claudiu T
CT
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D008670:Metals; D008968:Molecular Conformation; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry*; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008670:Metals; D012459:Salicylates; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc; D001241:Aspirin