title: Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines: I. Assessment of 'resistance' versus 'susceptibility' to S. japonicum infection.
abstract: This study describes the categorical classification of 155 individuals living in an endemic village in Macanip, Leyte, Philippines as 'resistant' or 'susceptible' to Schistosoma japonicum infection using available exposure, infection and reinfection data collected from a 3-year water contact (WC) study. Epidemiological parameters including age, sex, and infection intensities in relation to observed reinfection patterns are also described. This classification was used in subsequent immunological studies described in two accompanying papers to identify protective immune mechanisms among resistant individuals induced by defined candidate vaccine molecules for S. japonicum. The study suggests that individuals who were most vulnerable to rapid reinfection were children belonging to the 5-14 age group. A drop in incidence at age group 15-19 and decreased intensity of infection starting at this age group and older (15+) suggests development of immunity. Controlling for the effect of the other variables, a multivariate analysis showed significant association for sex, in that females were more likely to be resistant. This implies that other than acquired immunity to infection, some age-dependent host factors may also play an important role in the overall changes of reinfection patterns seen in schistosomiasis japonica in this population.
authors.affiliation: Research Institute for Tropical Medicine, FICC Compound, Alabang, Muntinlupa City, Philippines. lacosta@ritm.gov.ph
authors.forename: Luz P
authors.initials: LP
authors.lastname: Acosta
authors.forename: Gemiliano D L
authors.initials: GD
authors.lastname: Aligui
authors.forename: Wilfred U
authors.initials: WU
authors.lastname: Tiu
authors.forename: Donald P
authors.initials: DP
authors.lastname: McManus
authors.forename: Remigio M
authors.initials: RM
authors.lastname: Olveda
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010679:Philippines / Q000453:epidemiology; D012549:Schistosoma japonicum; D012554:Schistosomiasis japonica / Q000453:epidemiology / Q000276:immunology*; D017678:Sex Distribution