title: Evaluation of the long pulsed high fluence alexandrite laser therapy of leg telangiectasia.
abstract: OBJECTIVE
  The treatment of larger leg veins with laser or intense pulsed light often shows varying degrees of success and inconsistent clinical response rates. Aim of this study was to evaluate the effectiveness and safety of the 755 nm long pulsed high fluence alexandrite laser in the treatment of larger leg veins.
  
  
  METHODS
  Twenty female volunteers aged 25-51 years (mean 39) with 0.3-1.3 mm leg telangiectasias received laser treatment, 10 of them with an additional pass done right after the first pass. Their skin type ranged from 1 to 3 (five type 1, seven type 2, eight type 3). After test spots with increasing fluences (40-90 J/cm(2)) to determine the individual safe fluence, the maximum fluence of 90 J/cm(2) could be used in all 20 subjects. The spot size was 3 x 10 mm, a spray cooling system was used with 80 milliseconds spray and delay time, respectively. The number of pulses administered ranged from 30 to 467 per subject (mean 139). The treated area was controlled 1 day, 1 month, and 3 months post-treatment and the side effects were quantified. At each visit, the treatment area was photographed. The percent clearance in the treated areas was scored by two observers. Subject satisfaction was evaluated at the 3 months post-treatment visit.
  
  
  RESULTS
  After 3 months, in all 20 test subjects some clearance was visible. It ranged from low-grade to complete clearance. Most subjects (15 of 20) had a clearance between 26 and 75%. Hyperpigmentation was observed in 15 subjects. Hypopigmentation was seen in two subjects. No edema, no purpura, no erythema, no scarring, no blistering, and no crusts were observed. Mean subject satisfaction score was assessed and all volunteers reported to be "satisfied."
  
  
  CONCLUSIONS
  The long pulsed high fluence alexandrite laser is effective and safe in the treatment of leg veins 0.3-1.3 mm in diameter.
authors.affiliation: Department of Dermatology, University Hospital of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Brunnberg
authors.forename: Susanne
authors.initials: S
authors.lastname: Lorenz
authors.forename: Michael
authors.initials: M
authors.lastname: Landthaler
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hohenleutner
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000473:pathology / Q000528:radiation effects*; D028022:Low-Level Light Therapy / Q000009:adverse effects*; D008875:Middle Aged; D017060:Patient Satisfaction; D010859:Pigmentation Disorders / Q000209:etiology* / Q000473:pathology; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D013684:Telangiectasis / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors; D016896:Treatment Outcome