title: First report of CRF03_AB recombinant HIV type 1 in injecting drug users in Ukraine.
abstract: It has been reported that subtypes A throughout H of HIV-1 are circulating in the former Soviet Union. In this sequence note, we analyzed the genetic prevalence of HIV-1 among injecting drug users (IDUs) in Ukraine. The subjects studied included two individuals from Kiev and six individuals from Simferopol', the latter located in the Crimean Peninsula. We found that one of eight IDUs was infected with a CRF03 gagA/envB recombinant HIV-1 and was from Simferopol', whereas the others were infected with HIV-1 subtype A. There combinant was closely related to other A/B recombinants reported previously, and had silent mutations Inthe V3 region, the same as other envB strains of HIV-1 circulating among mDUs in the former Soviet Union. The data supported reports that the Russian AIB recombinant HIV-1 was probably from Ukraine. This is the first report of a CRF03 gagA/envB recombinant HIV-1 found in Ukraine.
authors.affiliation: Department of Public Health, Yokohama City University School of Medicine, Kanagawa, 236-0004 Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Naganawa
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Sato
authors.forename: Dmitri
authors.initials: D
authors.lastname: Nossik
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Hara
authors.forename: Osamu
authors.initials: O
authors.lastname: Tochikubo
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kitamura
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Honda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakasone
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D015819:Substance Abuse, Intravenous / Q000150:complications*; D014455:Ukraine / Q000453:epidemiology
chemical_list: D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments