title: New tools and concepts for modern organic synthesis.
abstract: The increasing need to efficiently assemble small molecules as potential modulators of therapeutic targets that are emerging from genomics and proteomics is driving the development of novel technologies for small-molecule synthesis. Here, we describe some of the general applications and approaches to synthesis using one such technology--solid-supported reagents--that has been shown to significantly improve productivity in the generation of combinatorial libraries and complex target molecules.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. svl1000@cam.ac.uk
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
mesh_terms: D009930:Organic Chemicals / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D009930:Organic Chemicals; D011108:Polymers