title: Fine-needle aspiration cytology diagnosis of metastatic gastrointestinal stromal tumor in the liver: a report of three cases.
abstract: Gastrointestinal stromal tumor (GIST) is the designation for a major subset of gastrointestinal mesenchymal tumors that histologically, immunocytochemically, and genetically differ from leiomyomas, leiomyosarcomas, and schwannomas. GISTs derive from the interstitial cells of Cajal and, in addition to variable expression of smooth muscle and neural markers, they characteristically express CD34 and CD117. The cytological appearance, including immunocytochemical and mutational analysis of c-kit gene in primary GIST has been well described. To our knowledge, only two cases of metastatic GIST diagnosed by fine-needle aspiration (FNA) have been reported. We illustrate three cases of metastatic GIST in the liver. Two cases had no prior history of gastrointestinal tumor and the third case had a 4-yr previous history of duodenal tumor. Consistent immunocytochemistry and ultrastructual studies supported the diagnosis of GIST. We emphasize that in the appropriate clinical and radiological setting, a confident diagnosis of GIST can be established by FNA of metastatic lesions.
authors.affiliation: Department of Pathology, Corporació Parc Taulí, Sabadell, Barcelona, Spain. cpadilla@cspt.es
authors.forename: Catalina
authors.initials: C
authors.lastname: Padilla
authors.forename: Amparo
authors.initials: A
authors.lastname: Saez
authors.forename: August
authors.initials: A
authors.lastname: Vidal
authors.forename: Lluis
authors.initials: L
authors.lastname: Garcia
authors.forename: Filomena
authors.initials: F
authors.lastname: Tolosa
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Andreu
authors.forename: Neus
authors.initials: N
authors.lastname: Combalia
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001707:Biopsy, Needle; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000556:secondary* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D014408:Biomarkers, Tumor