title: Mathematical analysis of subtypes of muscarinic receptors modulating heart and respiratory rhythms in rats.
abstract: Mathematical analysis of the data obtained in experiments on the whole organism revealed that blockade of M(2)-cholinergic receptors increased both heart and respiratory rates. Blockade of M(1)-cholinergic receptors alleviated tachycardia induced by M(2)-receptor blockade.
authors.affiliation: Institute of Toxicology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Lychakov
authors.forename: V A
authors.initials: VA
authors.lastname: Belyaev
authors.forename: A B
authors.initials: AB
authors.lastname: Kosmachev
authors.forename: R I
authors.initials: RI
authors.lastname: Glukhova
authors.forename: S G
authors.initials: SG
authors.lastname: Dagaev
authors.forename: V B
authors.initials: VB
authors.lastname: Dolgo-Saburov
mesh_terms: D000818:Animals; D006321:Heart / Q000502:physiology*; D006339:Heart Rate; D008024:Ligands; D016014:Linear Models; D008962:Models, Theoretical; D051381:Rats; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011950:Receptors, Cholinergic / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012119:Respiration; D013909:Thorax / Q000502:physiology
chemical_list: D008024:Ligands; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic