Duplicating dangerously: linking centrosome duplication and aneuploidy.
Centrosomes are far more fascinating than the first explorers of this organelle a century ago could ever have imagined. Recent evidence indicates that deregulation of centrosome duplication affects centrosome number and promotes aneuploidy, features characteristic of human tumors.
Doxsey
Stephen
S
Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
D000782:Aneuploidy; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D018385:Centrosome / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics
D018797:Cell Cycle Proteins