title: Does adrenal mass size really affect safety and effectiveness of laparoscopic adrenalectomy?
abstract: OBJECTIVE
  To evaluate the effectiveness and safety of laparoscopic adrenalectomy with regard to adrenal mass size, as well as to consider its clinical and pathologic patterns. Laparoscopy is today considered the first-choice treatment of many adrenal diseases, although its use is still controversial for large adrenal masses and incidentally found adrenal cortical carcinoma.
  
  
  METHODS
  A total of 125 patients underwent lateral transperitoneal laparoscopic adrenalectomy. The indications were either functioning or nonfunctioning adrenal masses, without any radiologic evidence of involvement of the surrounding structures. The correlation between the size and the operative times, estimated blood loss, incidence of intraoperative and postoperative complications, and length of hospital stay were studied with Pearson's correlation coefficient, Fisher's exact test, and the chi-square test. The analysis of variance test was used to evaluate any possible correlation between the size and clinicopathologic features and the results.
  
  
  RESULTS
  A slight correlation was observed between the size and operative time (P = 0.004), but no correlation was observed between the size and the other parameters. Statistical analysis showed a significant correlation between the clinicopathologic patterns (nonfunctioning benign adrenal masses, Conn's adenoma, Cushing's adenoma, pheochromocytoma, adrenal cortical cancer, and other tumor metastasis) and the operative time (P = 0.011), but not with the other parameters.
  
  
  CONCLUSIONS
  Laparoscopic adrenalectomy is also effective and safe for large lesions. The results of our series confirms that the risk of encountering an incidental adrenal cortical cancer is significantly increased for large lesions, and therefore, in these cases, additional attention is required to observe oncologic surgical principles.
authors.affiliation: Divisione Universitaria di Urologia, Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Ospedale San Luigi, Orbassano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Porpiglia
authors.forename: P
authors.initials: P
authors.lastname: Destefanis
authors.forename: C
authors.initials: C
authors.lastname: Fiori
authors.forename: G
authors.initials: G
authors.lastname: Giraudo
authors.forename: C
authors.initials: C
authors.lastname: Garrone
authors.forename: R M
authors.initials: RM
authors.lastname: Scarpa
authors.forename: D
authors.initials: D
authors.lastname: Fontana
authors.forename: M
authors.initials: M
authors.lastname: Morino
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000601:surgery*; D000315:Adrenalectomy / Q000009:adverse effects* / Q000379:methods; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002648:Child; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D012449:Safety; D013997:Time Factors