[Cerebral ischemia and histamine].
Cerebral ischemia induces excess release of glutamate and an increase in the intracellular Ca2+ concentration, which provoke catastrophic enzymatic processes leading to irreversible neuronal injury. Histamine plays the role of neurotransmitter in the central nervous system, and histaminergic fibers are widely distributed in the brain. In cerebral ischemia, release of histamine from nerve endings has been shown to be enhanced by facilitation of its activity. An inhibition of the histaminergic activity in ischemia aggravates the histologic outcome. In contrast, intracerebroventricular administration of histamine improves the aggravation, whereas blockade of histamine H2 receptors aggravates ischemic injury. Furthermore, H2 blockade enhances ischemic release of glutamate and dopamine. These findings suggest that central histamine provides beneficial effects against ischemic neuronal damage by suppressing release of excitatory neurotransmitters. However, histaminergic H2 action facilitates the permeability of the blood-brain barrier and shows deleterious effects on cerebral edema.
Adachi
Naoto
N
Department of Anesthesiology and Resuscitology, Ehime University School of Medicine, Ehime 791-0295, Japan. nadachi@m.ehime-u.ac.jp
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D006632:Histamine / Q000502:physiology*; D006636:Histamine Release / Q000502:physiology; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology
D018377:Neurotransmitter Agents; D006632:Histamine