title: Recent developments in amperometric detection for microchip capillary electrophoresis.
abstract: The interest in microfluidic devices has increased considerably over the past decade due to the numerous advantages of working within a miniature, microfabricated format. This review focuses on recent advances in coupling amperometric detection with microchip capillary electrophoresis (CE). Advances in electrochemical cell design, isolation of the detector from the separation field, and integration of both pre- and postseparation reaction chambers are discussed. The use of microchip CE with amperometric detection for enzyme/immunoassays, clinical and environmental assays, and the determination of neurotransmitters is described.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
authors.forename: Walter R
authors.initials: WR
authors.lastname: Vandaveer
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Pasas
authors.forename: R Scott
authors.initials: RS
authors.lastname: Martin
authors.forename: Susan M
authors.initials: SM
authors.lastname: Lunte
mesh_terms: D019963:Clinical Chemistry Tests; D019075:Electrophoresis, Capillary / Q000295:instrumentation* / Q000379:methods; D004785:Environmental Pollutants / Q000032:analysis; D007118:Immunoassay; D008832:Microchemistry / Q000295:instrumentation; D008839:Microelectrodes; D018377:Neurotransmitter Agents / Q000032:analysis
chemical_list: D004785:Environmental Pollutants; D018377:Neurotransmitter Agents