title: [Glutathione in therapy].
abstract: It has been commonly accepted that oxidative stress is involved in pathogenesis of many serious and even lethal health disturbances, including neurodegenerative diseases, diabetes, alcoholic disease, viral and bacterial infections. In this paper we discuss the protective antioxidative role of glutathione, the predominant non-protein thiol in mammalian cells. We also emphasize the perspectives of glutathione therapy i.e. application of both cysteine and glutathione precursors.
authors.affiliation: Zakład Regulacji Metabolizmu, Instytut Biochemii Uniwersytetu Warszawskiego. k.winiarska@biol.uw.edu.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Winiarska
authors.forename: Jakub
authors.initials: J
authors.lastname: Drozak
mesh_terms: D000818:Animals; D003545:Cysteine / Q000378:metabolism / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D011761:Pyrrolidonecarboxylic Acid; D013844:Thiazoles / Q000378:metabolism / Q000627:therapeutic use; D053778:Thiazolidines
chemical_list: D013844:Thiazoles; D053778:Thiazolidines; D005978:Glutathione; D003545:Cysteine; D011761:Pyrrolidonecarboxylic Acid; C029536:2-oxothiazolidine-4-carboxylic acid