title: Study on the distribution of nodularin in tissues and cell level in mice.
abstract: OBJECTIVE
  To study the tissue distribution of nodularin in mice and the cellular location of nodularin in the target organs.
  
  
  METHODS
  The nodularin was labeled with radioactive isotope (125)I and then was given to mice via oral, intraperitoneal and intravenous administration. The distribution of nodularin in target organs and the cellular location of nodularin were studied by radioisotope and autoradiography techniques.
  
  
  RESULTS
  The radioisotope study results showed that nodularin was mainly distributed in the kidney and liver in mice. Further autoradiography study indicated that nodularin was distributed in the renal cell nuclei and liver cell nuclei.
  
  
  CONCLUSIONS
  The kidney and liver are the two main target organs for nodularin in mice.
authors.affiliation: Institute of Preventive Medicine, School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Zhanying
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shunzhang
authors.initials: S
authors.lastname: Yu
authors.forename: Chuanwei
authors.initials: C
authors.lastname: Chen
authors.forename: Guorong
authors.initials: G
authors.lastname: Wei
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008387:Marine Toxins / Q000493:pharmacokinetics*; D051379:Mice; D010456:Peptides, Cyclic / Q000493:pharmacokinetics*
chemical_list: D008387:Marine Toxins; D010456:Peptides, Cyclic; C063998:nodularin