[Angina attack caused by 5-fluorouracil infusion--report of a case and review of the literature].
Cardiac toxicity of 5-fluorouracil (5-FU) has been rarely reported. We encountered a case of angina attack caused by 5-FU. A 58-year-old Japanese woman underwent sigmoidectomy for a sigmoid colon carcinoma with multiple liver metastases. Two months after surgery, she received chemotherapy comprising hepatic arterial infusion of 5-FU. During the 2nd chemotherapy session 7 days after the first, she complained of anterior chest pain. Her electrocardiograms showed elevations of the ST segment in almost all leads, confirming the diagnosis of angina pectoris. Soon after the third chemotherapy session the same type of attack occurred again. The close association of the attacks with 5-FU administration suggested that the angina might have been induced by 5-FU. Further attacks were avoided by discontinuing the 5-FU thereafter. The incidence of cardiac toxicity 5-FU has been reported to be 1.6-7.6%. Labianca et al. found 17 cases of 5-FU-associated cardiopathy, 15 of which were angina pectoris, out of 1,083 patients treated with the drug for various kinds of neoplasm. Analysis of 6 domestic cases including ours revealed that all patient lacked a previous history of cardiac disease except one who had an arrhythmia. There seemed to be no dose-dependent correlation with 5-FU-induced angina. Cardiac events were found even in the earlier phase of chemotherapy. Since 5-FU is widely used in the treatment of a number of gastrointestinal malignancies, one should bear in mind its cardiac toxicity, manifested as angina pectoris.
Yokoyama
Taku
T
Dept. of Surgery, Utsunomiya Social Insurance Hospital.
Hosoya
Yoshinori
Y
Aoki
Torao
T
Saito
Shin
S
Nihei
Yoshito
Y
Kobayashi
Nobuhisa
N
Shoji
Masahiro
M
Saito
Yoshinori
Y
Nagai
Hideo
H
D000787:Angina Pectoris / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D012811:Sigmoid Neoplasms / Q000473:pathology / Q000601:surgery
D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; D005472:Fluorouracil