title: Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery.
abstract: BACKGROUND
  WBC-replete blood transfusion has been suggested as an independent cause of increased postoperative infection.
  
  
  METHODS
  A total of 597 patients undergoing elective coronary artery or heart valve surgery were randomly assigned to receive plasma-reduced (PR), buffy coat-depleted (BCD), or WBC-filtered (WCF) RBCs in the event of requiring blood transfusion. Details of postoperative course were recorded. Further information was collected from the patient's general practitioner 3 months after discharge.
  
  
  RESULTS
  No significant difference in inpatient infection rates was observed among patients randomly assigned to receive PR, BCD, or WCF RBCs. When only those receiving transfusion were analyzed (n = 509), use of PR RBCs was associated with more events coded as infections (p < or = 0.05) compared with BCD or WCF RBCs. However, when events coded as urinary tract infections were excluded, there was no significant difference among the three groups. Follow-up performed after discharge showed no difference in readmission rates, but a higher reported rate of infection in those randomly assigned to receive WCF RBCs (p < 0.02).
  
  
  CONCLUSIONS
  No evidence has been found, analyzed by intention to treat, that use of WBC-reduced, BCD, or WCF RBCs reduces postoperative inpatient infection in patients undergoing cardiac bypass surgery.
authors.affiliation: Department of Haematology, Freeman Hospital, High Heaton, Newcastle upon Tyne, United Kingdom. jonathan.wallis@tfh.nuth.northy.nhs.uk
authors.forename: J P
authors.initials: JP
authors.lastname: Wallis
authors.forename: C E
authors.initials: CE
authors.lastname: Chapman
authors.forename: K E
authors.initials: KE
authors.lastname: Orr
authors.forename: S C
authors.initials: SC
authors.lastname: Clark
authors.forename: J R
authors.initials: JR
authors.lastname: Forty
mesh_terms: D000368:Aged; D001787:Blood Group Incompatibility; D006348:Cardiac Surgical Procedures; D011232:Chemical Precipitation; D001026:Coronary Artery Bypass; D003428:Cross Infection / Q000453:epidemiology* / Q000209:etiology; D017558:Elective Surgical Procedures; D004739:England / Q000453:epidemiology; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005374:Filtration; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007962:Leukocytes; D008297:Male; D019300:Medical Errors; D008875:Middle Aged; D010949:Plasma; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000209:etiology