title: Host range and receptor binding properties of vectors bearing feline leukemia virus subgroup B envelopes can be modulated by envelope sequences outside of the receptor binding domain.
abstract: To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs is mediated primarily by the receptor binding domain; however, in the case of FeLV-B-90Z, the C terminus also contributes to the recognition of certain Pit1 orthologs.
authors.affiliation: Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
authors.forename: Peggy Ho
authors.initials: PH
authors.lastname: Faix
authors.forename: Steven A
authors.initials: SA
authors.lastname: Feldman
authors.forename: Julie
authors.initials: J
authors.lastname: Overbaugh
authors.forename: Maribeth V
authors.initials: MV
authors.lastname: Eiden
mesh_terms: D000818:Animals; D002415:Cats; D002460:Cell Line; D005822:Genetic Vectors; D005256:Leukemia Virus, Feline / Q000145:classification / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D051379:Mice; D008907:Mink; D017434:Protein Structure, Tertiary; D011817:Rabbits; D051381:Rats; D011991:Receptors, Virus / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D012190:Retroviridae / Q000235:genetics; D013045:Species Specificity; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D014774:Virulence
chemical_list: D011991:Receptors, Virus; D011993:Recombinant Fusion Proteins; D014759:Viral Envelope Proteins; C067981:leukemia virus receptor, gibbon ape