title: Serological observations in patients suffering from acute manic episodes.
abstract: Although abnormalities of the immune system have been described in depression, information on serological alteration in acutely manic patients has been scarce. The present study undertook to investigate the levels of C-reactive proteins, circulating immune complexes, total immunoglobulins and immunoglobulin subclasses, complement proteins C3, C4, C6 and Factor B in the sera of 45 patients suffering from an acute manic episode. The findings were compared with assessments on the sera of 45 controls. The results demonstrate a number of significant differences between patients and controls. Whilst levels of immunoglobulin D were significantly lower, the levels of total immunoglobulin and immunoglobulin G1, complement proteins C3, C6 and Factor B were raised in the patient group when compared with the controls. Our results suggest a relationship between acute mania and immunological parameters associated with acute phase responses.
authors.affiliation: Department of Immunology, Faculty of Health Sciences and School of Pathology of the University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, 2000, South Africa. bronwynb@mail.saimr.wits.ac.za
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Wadee
authors.forename: Reverie H
authors.initials: RH
authors.lastname: Kuschke
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Wood
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.forename: Liuvu
authors.initials: L
authors.lastname: Ichim
authors.forename: Michael
authors.initials: M
authors.lastname: Maes
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood / Q000276:immunology*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D003165:Complement System Proteins; D002097:C-Reactive Protein