Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein.
Cummins
Carolyn L
CL
Department of Biopharmaceutical Sciences, University of California San Francisco, USA.
Wu
Chi-Yuan
CY
Benet
Leslie Z
LZ
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000502:physiology*; D000818:Animals; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D004917:Erythromycin / Q000493:pharmacokinetics; D006801:Humans; D008657:Metabolic Clearance Rate; D008874:Midazolam / Q000493:pharmacokinetics; D012727:Sex Characteristics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004917:Erythromycin; D003577:Cytochrome P-450 Enzyme System; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; D008874:Midazolam