title: TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle.
abstract: OBJECTIVE
  We performed a case-control study to assess the association between obesity risk and the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene.
  
  
  METHODS
  Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2] and controls (n = 154; BMI < 25 kg/m2) were compared using multivariable logistic regression to control for potential confounders.
  
  
  RESULTS
  A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00-8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people.
  
  
  CONCLUSIONS
  Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.
authors.affiliation: Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain. amarti@unav.es
authors.forename: A
authors.initials: A
authors.lastname: Marti
authors.forename: M S
authors.initials: MS
authors.lastname: Corbalán
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez-Gonzalez
authors.forename: J A
authors.initials: JA
authors.lastname: Martinez
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D011943:Receptors, Adrenergic, beta