The boosting of didanosine by allopurinol permits a halving of the didanosine dosage.
Boelaert
Johan R
JR
Department of Internal Medicine and Infectious Diseases, Algemeen Ziekenhuis St Jan, Brugge, Belgium.
Dom
Geneviève M
GM
Huitema
Alwin D
AD
Beijnen
Jos H
JH
Lange
Joep M
JM
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016049:Didanosine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006679:HIV Seropositivity / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D008297:Male; D010865:Pilot Projects; D012367:RNA, Viral / Q000097:blood*
D019380:Anti-HIV Agents; D004791:Enzyme Inhibitors; D012367:RNA, Viral; D000493:Allopurinol; D016049:Didanosine; D006918:Hydroxyurea