Lovastatin induces cell death in cardiomyocytes that is not reversible by coenzyme Q 10.
Rabkin
Simon W
SW
University of British Columbia, Vancouver, B.C., Canada. rabkin@interchange.ubc.ca
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D003067:Coenzymes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008148:Lovastatin / Q000009:adverse effects*; D009206:Myocardium / Q000166:cytology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D003067:Coenzymes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; D008148:Lovastatin; C024989:coenzyme Q10