Tissue array technique for p53 expression in human ovarian neoplasms.
OBJECTIVE
To investigate the expression of p53 in human ovarian neoplasms by tissue array technique.


METHODS
The expression of p53 protein in various ovarian tissues was studied by tissue array and immunohistochemistry.


RESULTS
The expression rate of p53 was 33% in ovarian cancers. There were no expressions in normal ovarian tissues, benign ovarian neoplasms and borderline ovarian neoplasms (P < 0.005). p53 expression was not associated with age of patients and grade of differentiation (P > 0.05) while p53 expression was associated with tissue types (P < 0.05).


CONCLUSIONS
The expression rates of p53 in ovarian cancers were obviously increased.
Wang
Yapin
Y
Department of Obstetrics and Gynecology, People's Hospital of Guizhou Province, Guiyang 550002, China.
Wang
He
H
Peng
Zhilan
Z
Yang
Kaixuan
K
D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms; D016159:Tumor Suppressor Protein p53
D016159:Tumor Suppressor Protein p53