title: SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication. Single photon emission computed tomography.
abstract: BACKGROUND
  Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes.
  
  
  OBJECTIVE
  Our aims were: to assess the accuracy of SPECT with three dimensional image analysis to measure balloon volumes in vitro; to compare gastric barostat balloon volumes measured post-meal and post-distension with total gastric volumes measured simultaneously with SPECT; to present normal gastric volume data for healthy adults; and to compare SPECT data in health with symptomatic post-fundoplication patients.
  
  
  RESULTS
  In vitro balloon volumes measured by SPECT were highly accurate (R(2)=0.99). When measured simultaneously by gastric barostat and SPECT, postprandial/fasting volume ratios (2.2 (0.12) (mean (SEM)) v 2.3 (0.15), respectively; p=0.6) and post-distension volume ratios (1.4 (0.1) v1.3 (0.1); p=0.2) were highly comparable. In females, postprandial gastric volumes (675 (14) v 744 (20) ml for males; p=0.004) and changes in gastric volumes (464 (14) ml v 521 (20) ml for males; p=0.01) measured by SPECT were significantly lower than in males. No effects of age or body mass index were noted. The postprandial/fasting gastric volume ratio by SPECT was lower in post-fundoplication patients (2.7 (0.2)) than in healthy controls (3.4 (0.1); p=0.003).
  
  
  CONCLUSIONS
  SPECT provides a non-invasive estimate of the effect of a meal on total gastric volume that is comparable to changes in balloon volume observed with the gastric barostat. The SPECT technique is promising for investigation of gastric volumes in health and disease and the effects of pharmacological agents.
authors.affiliation: Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: E P
authors.initials: EP
authors.lastname: Bouras
authors.forename: S
authors.initials: S
authors.lastname: Delgado-Aros
authors.forename: M
authors.initials: M
authors.lastname: Camilleri
authors.forename: E J
authors.initials: EJ
authors.lastname: Castillo
authors.forename: D D
authors.initials: DD
authors.lastname: Burton
authors.forename: G M
authors.initials: GM
authors.lastname: Thomforde
authors.forename: H J
authors.initials: HJ
authors.lastname: Chial
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D004415:Dyspepsia / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D005260:Female; D018662:Fundoplication; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011312:Pressure; D012016:Reference Values; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013270:Stomach / Q000000981:diagnostic imaging* / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon