Bone mineralization in senescence-accelerated OXYS rats.
We compared age-related changes in the mineral composition of bone tissues in Wistar and senescence-accelerated OXYS rats. The mass concentrations of calcium, phosphorus, and magnesium were measured by atomic emission spectrometry. OXYS rats are characterized by early mineralization of the bone tissue, which peaked by the 6th month of life. Mineralization defects in 12-month-old OXYS rats included accumulation of iron and phosphorus, decrease in the Ca/P ratio, and increase in ash weight. These changes reflected early development and accelerated aging of these animals. Studies of the bone tissue in OXYS rats indicate that these animals can be used for evaluation of the mechanisms of involutional osteoporosis.
Kolosova
N G
NG
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk State Medical Academy, Novosibirsk. kolosova@iph.ma.nsc.ru
Kutorgin
G D
GD
Safina
A F
AF
D000375:Aging / Q000502:physiology*; D000818:Animals; D002113:Calcification, Physiologic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar
D010758:Phosphorus; D007501:Iron; D008274:Magnesium; D002118:Calcium