title: De Novo design, synthesis, and in vitro evaluation of a new class of nonpeptidic inhibitors of the malarial enzyme plasmepsin II.
authors.affiliation: Laboratorium für Organische Chemie ETH-Hönggerberg, HCI 8093 Zürich, Switzerland.
authors.forename: David A
authors.initials: DA
authors.lastname: Carcache
authors.forename: Simone R
authors.initials: SR
authors.lastname: Hörtner
authors.forename: Andreas
authors.initials: A
authors.lastname: Bertogg
authors.forename: Christoph
authors.initials: C
authors.lastname: Binkert
authors.forename: Daniel
authors.initials: D
authors.lastname: Bur
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Märki
authors.forename: Arnulf
authors.initials: A
authors.lastname: Dorn
authors.forename: François
authors.initials: F
authors.lastname: Diederich
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000201:enzymology; D015800:Protozoan Proteins; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D004791:Enzyme Inhibitors; D015800:Protozoan Proteins; D016282:Aspartic Acid Endopeptidases; C100637:plasmepsin II