[Study on intervention and comparison of rational use of antibiotics on perioperative period of clean incision and clean-defiled incision].
OBJECTIVE
To explore a set of scientific evaluation and intervention methods on perioperatur period which fits for China's situation, and to promote the development of rational drug use.


METHODS
Two would tertiary general hospitals were selected and separated in to intervention group and control group. Intervention was carried out and compared at the same period on inpatient surgical cases of thryroidectomy, mastectomy, cholescystectomy, and hysteromyomectomy plus appendix.


RESULTS
The average drug costs was decreased from 1 601.27 yuan to 1 489.59 yuan and the average antibiotics use from 740.20 yuan to 352.03 yuan (P < 0.01) in the intervention group pre and post intervention. There was a remarkable improvement on the rationality of antibiotics use in intervention group, from 31.35% to 91.81% (P < 0.01) pre and post intervention, implemented in the hospital.


CONCLUSIONS
It is practicable and effective to implement rational drug use where intervention was carried out, since it plays an active role on promoting safely, effectively and economic antibiotic use in China.
Wang
Yuqin
Y
Department of Pharmacy, Xuanwu Hospital of the Capital University of Medical Sciences, Beijing 100053, China.
Wang
Lihong
L
Xu
Yanxia
Y
Wang
Shujie
S
Wang
Jialin
J
Jiang
Ping
P
Li
Fei
F
Shi
Haiou
H
Wang
Hailian
H
Zhang
Jingli
J
Chen
Lianzhen
L
Liu
Jiang
J
Wang
Qing
Q
D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use*; D016527:Drug Costs; D004363:Drug Utilization / Q000191:economics; D013502:General Surgery; D006801:Humans; D019990:Perioperative Care
D000900:Anti-Bacterial Agents