High CD4+ T-cells percentage and/or low viral load are predictors of 1-5 years survival in HIV-1 vertically infected Thai children.
OBJECTIVE
Enrolling pediatric HIV children into the clinical trial of when to initiate antiretroviral therapy is a crucial ethical issue. CD4+ T-cells percentage and/or viral load were able to identify potential cases of survival through 5 years of age.


METHODS
HIV infected cohort from 1992 to 1994 from Children's and Siriraj Hospitals were followed from 1 through 5 years of age. The outcome was survival or death. The predictors were CD4 percentage and viral load (without age and clinical status adjustment).


RESULTS
16 of 35 (45.71%) of the cohort survived through 5 years of age. The probability of survival increased to almost 100 per cent either with CD4+ T-cells percentage of over 22 or viral load of less than 500,000.
Vanprapar
Nirun
N
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Chearsakul
Sanay
S
Chokephaibulkit
Kulkanya
K
Phongsamart
Wanatpreeya
W
Lolekha
Rangsima
R
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000401:mortality* / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016019:Survival Analysis; D013785:Thailand / Q000453:epidemiology; D019562:Viral Load
D015415:Biomarkers; D015704:CD4 Antigens