title: Cardiovascular autonomic function and sympathetic skin response in chronic inflammatory demyelinating polyradiculoneuropathy.
abstract: Quantitative cardiovascular autonomic function tests (AFTs) and sympathetic skin response (SSR) were performed in 12 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Parasympathetic autonomic function was examined by Valsalva ratio and R-R interval variation during rest and deep breathing. Sympathetic autonomic function was evaluated by blood pressure responses to sustained handgrip and active standing. Using quantitative AFTs, subclinical autonomic dysfunction was demonstrated in three (25%) patients. Abnormal SSR was seen in six (50%) patients. Thus, mild autonomic dysfunction is present in many CIDP patients. The autonomic abnormalities involve parasympathetic or sympathetic components; in the sympathetic nervous system, both vasomotor and sudomotor fibers may be involved.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital and University, 199 Tung Hwa North Road, Taipei, Taiwan. lyu5172@adm.cgmh.org.tw
authors.forename: Rong-Kuo
authors.initials: RK
authors.lastname: Lyu
authors.forename: Lok-Ming
authors.initials: LM
authors.lastname: Tang
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
authors.forename: Sien-Tsong
authors.initials: ST
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000473:pathology / Q000503:physiopathology*; D012678:Sensation Disorders / Q000473:pathology / Q000503:physiopathology; D012791:Shy-Drager Syndrome / Q000473:pathology / Q000503:physiopathology; D017779:Sympathetic Fibers, Postganglionic / Q000473:pathology / Q000503:physiopathology*; D014636:Valsalva Maneuver / Q000502:physiology