Solid-phase, Pd-catalyzed silicon-aryl carbon bond formation. Synthesis of sansalvamide A peptide.
A palladium-catalyzed silicon-aryl carbon bond formation on solid-phase is reported. A phenylalanine silane resin was prepared directly from protected iodo-substituted phenylalanine with butyl diethylsilane polystyrene in one step. A rapid and high-yield solid-phase synthesis of sansalvamide A peptide was achieved from the phenylalanine silane resin. [reaction: see text]
Gu
Wenxin
W
Department of Chemistry and Drug Discovery Program, Northwestern University, Evanston, IL 60208-3113, USA.
Liu S
Shouxin
S
Silverman
Richard B
RB
D047630:Depsipeptides; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D010165:Palladium; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D010649:Phenylalanine; D012825:Silicon
D047630:Depsipeptides; D007202:Indicators and Reagents; D010455:Peptides; D010456:Peptides, Cyclic; C119376:sansalvamide A; D010649:Phenylalanine; D010165:Palladium; D012825:Silicon