title: Quantitative imaging and correction for cascade gamma radiation of 76Br with 2D and 3D PET.
abstract: Several positron emitting nuclides with applications in PET, such as 76Br, 124I, 110In and 86Y, also emit gamma radiation in their decays. Measured coincidences between annihilation photons and this cascade gamma radiation are essentially true coincidences and the standard PET corrections do not account for them. We investigated the performance of 76Br in 2D and 3D PET, the effect of the gamma radiation emitted by 76Br on quantitative accuracy and the distribution of cascade gamma radiation coincidences in 2D and 3D PET sinograms. A correction method for cascade gamma radiation coincidences was implemented and evaluated. Count rate linearity was affected by the gamma radiation from the 76Br decay. Spatial resolution and sphere recovery were slightly worse for 76Br compared to 18F. Correction for cascade gamma radiation coincidences by subtraction of a linear projection tail fit improved total correction accuracy to similar values as for positron-only emitters such as 18F, and improved image contrast significantly.
authors.affiliation: Section of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Sweden. mark.lubberink@pet.uu.se
authors.forename: Mark
authors.initials: M
authors.lastname: Lubberink
authors.forename: Harald
authors.initials: H
authors.lastname: Schneider
authors.forename: Mats
authors.initials: M
authors.lastname: Bergström
authors.forename: Hans
authors.initials: H
authors.lastname: Lundqvist
mesh_terms: D001967:Bromine Radioisotopes; D005462:Fluorine Radioisotopes; D005720:Gamma Rays; D007554:Isotopes; D019047:Phantoms, Imaging; D017785:Photons; D012542:Scattering, Radiation; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D001967:Bromine Radioisotopes; D005462:Fluorine Radioisotopes; D007554:Isotopes