title: Tritium labelling and characterization of the cognition enhancing drug tacrine using several precursors.
abstract: Tacrine and its analogues have shown promise as cognition enhancers and potential chemotherapeutic agents for Alzheimer's disease. [3H]tacrine was required to explore its mechanism of action via receptor binding assay and the radioligand was prepared by means of catalytic dehalogenation of several brominated precursors.
authors.affiliation: PerkinElmer Life Sciences, Inc, 549 Albany St, Boston, MA 02118, USA.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Egan
authors.forename: Richard P
authors.initials: RP
authors.lastname: Nugent
authors.forename: Crist N
authors.initials: CN
authors.lastname: Filer
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D018697:Nootropic Agents / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013619:Tacrine / Q000031:analogs & derivatives / Q000737:chemistry*; D014316:Tritium
chemical_list: D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents; D014316:Tritium; D013619:Tacrine