title: Lipid-based vehicle for oral drug delivery.
abstract: With an increasing number of lipophilic drugs under development, homolipids and heterolipids have gained renewed interests as excipients for oral drug delivery systems. Oral administration has many advantages for chronic drug therapy. It is relatively safe, convenient for the patient and allows self administration. This article is not intended to review the broad area of lipid-based vehicle for oral drug delivery comprehensively. The rationale behind choosing lipids materials for pharmaceutical dosage forms and their applications is discussed. It also comments on the methods for monitoring the physicochemical properties of vehicles and formulations and describes a range of pharmacopoeial excipients suitable for these purposes. The excipients selected here are pharmacopoeial in European Pharmacopoeia 4th Ed., United States Pharmacopoeia 24th Ed./National Formulary 19th Ed. and Japanese Pharmacopoeia 13th Ed. or are drafted in Pharmaeuropa and Pharmacopoeial Forum. Widening availability of lipidic excipients with specific characteristics offer flexibility of application with respect to improving the bioavailability of poorly water-soluble drugs and manipulating release profiles.
authors.affiliation: Research, Development and Clinical Department, IVAX-CR a.s., Ostravská 29, 747 70 Opava 9, Czech Republic. milan_stuchlik@ivax-cr.com
authors.forename: M
authors.initials: M
authors.lastname: Stuchlík
authors.forename: S
authors.initials: S
authors.lastname: Zák
mesh_terms: D000284:Administration, Oral; D016503:Drug Delivery Systems; D005079:Excipients; D006801:Humans; D008055:Lipids; D014677:Pharmaceutical Vehicles
chemical_list: D005079:Excipients; D008055:Lipids; D014677:Pharmaceutical Vehicles