Synthesis and some pharmacological properties of 3-(4-phenyl-5-oxo-1,2,4-triazolin-1-ylmethyl)-1,2,4-triazolin-5-thione derivatives.
In the reaction of (4-phenyl- or 3,4-diphenyl-5-oxo-1,2,4-triazeolin-1-ylmethyl)-carbohydrazide (IIa, IIb) with isothiocyanates the thiosemicarbazide derivatives [IIIa, b - IXa, b] were obtained. Cyclization of those compounds in the presence of 2% or 10% NaOH led to formation of derivatives with the 1,2,4-triazolin-5-thione system [Xa, b - XV[a, b]. Molecular structure proposed for this group of compounds was confirmed by X-ray structure analysis of Xa and XIVa. Compounds Xa, XIIa and XIVa were investigated pharmacologically for their central properties in mice. It was shown that only compound XIIa produced antinociceptive effects in mice.
Dobosz
Maria
M
Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Lublin, Poland
Struga
Marta
M
Chodkowska
Anna
A
Jagiełło-Wójtowicz
Ewa
E
Stepniak
Krystyna
K
Kozioł
Anna E
AE
D000818:Animals; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013678:Technology, Pharmaceutical / Q000379:methods / Q000706:statistics & numerical data; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D013871:Thiones; D014230:Triazoles