Effects of fluoxetine on the activity of phagocytosis in stressed mice.
We studied the effects of 1, 2, 5, 10 and 20 mg/kg of fluoxetine on the activity of phagocytosis in mice subjected to a chronic auditory stressor. Both the in vitro and in vivo activity of phagocytosis, measured using the zymosan-particle uptake method and the carbon clearance test, respectively, were reduced after 2, 4, 8 and 16 days of stress exposure. A partial recovery on the in vivo activity of phagocytosis was found on day 16th. Daily treatment with fluoxetine partially reversed the adverse effects of stress in a dose-dependent manner on both parameters but did not significantly affect the activity of phagocytosis in unstressed mice. Significant differences appeared when fluoxetine was administered at 2 mg/kg. Maximum effect was reached at 5 mg/kg.
Freire-Garabal
Manuel
M
Neuroimmunology Laboratory, Department of Pharmacology, Schools of Medicine and Nursing, University of Santiago de Compostela, 15705, Santiago de Compostela, Spain. fffregar@usc.es
Núñez
María J
MJ
Riveiro
Pilar
P
Balboa
José
J
López
Pablo
P
Zamorano
Braulio G
BG
Rodrigo
Elena
E
Rey-Méndez
Manuel
M
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000465:Algorithms; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects*; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009622:Noise / Q000009:adverse effects; D010587:Phagocytosis / Q000187:drug effects*; D013315:Stress, Psychological / Q000276:immunology*; D013997:Time Factors
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D000324:Adrenocorticotropic Hormone