Effects of pollen extract EA-10, P5 on chronic prostatitis or infertility with chronic prostatitis.
OBJECTIVE
To determine the drug action mechanism of pollen extract EA-10, P5 on the treatment of chronic prostatitis (CP) or infertility with CP.


METHODS
Malondiadehyde (MDA), superoxide dismutase (SOD), and nitrogen monoxide (NO) were measured by biochemical assay, and zinc content was assayed by atomical spectrophotography in the pre-treatment and post-treatment of CP or infertility with CP.


RESULTS
Compared with control group, leukocytes in expressed protatic secretion (LEPS), MDA, and NO were increased, and zinc content and SOD were decreased significantly in the pre-treatment of CP. After the treatment, LEPS was improved, and MDA and NO were reduced, while zinc content were increased apparently and the alteration of SOD was not evident (P>0.05). In the pre-treatment of infertility with CP, LEPS, MDA, NO, sperm viability, and seminal leukocytes were obviously higher and seminal plasma SOD, zinc content, and sperm motility were obviously lower than those in control group. After the treatment, LEPS, sperm motility, and sperm viability were improved, MDA, NO, and seminal leukocytes were decreased, SOD and zinc content were increased markedly.


CONCLUSIONS
There was inter-correlation between oxygen free radicals (OFR) and occurrence, development, and recovery of CP; Change of OFR may be involved in the drug action mechanism of EA-10, P5 in the treatment of CP or infertility with CP.
Chen
Hong-Jie
HJ
Institute of Urology, 2nd Affiliated Hospital of Lanzhou medical College, Lanzhou 730030, China.
Wang
Zhi-Ping
ZP
Chen
Yi-Rong
YR
Qin
Da-Shan
DS
Fu
Sheng-Jun
SJ
Ma
Bao-Liang
BL
D002908:Chronic Disease; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D011058:Pollen / Q000737:chemistry*; D011472:Prostatitis / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D012434:Secale / Q000737:chemistry; D012661:Semen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D010936:Plant Extracts; D009569:Nitric Oxide; D008315:Malondialdehyde; C010070:cernilton; D013482:Superoxide Dismutase; D015032:Zinc