Plasma noradrenaline response to a cognitive stressor in subtypes of depressive illness.
Noradrenergic function has been shown to be disrupted in depressive illness. The plasma noradrenaline response to a cognitive stressor (the Stroop test) was used to investigate noradenergic activity in subtypes of depressive illness. A Stroop test was carried out, under standardised conditions, on patients with melancholic or psychotic depression, non-melancholic depression, general anxiety disorder and normal controls. Blood samples were taken during testing for measurement of plasma noradrenaline. Although there was a trend for the plasma noradrenergic response to be reduced in the melancholic/psychotic depressed patients compared to all other groups, this did not reach statistical significance. No other inter-group comparisons were statistically significant. The plasma noradrenaline response to a cognitive stressor does not discriminate subtypes of depressive illness from normal controls. Copyright 2000 John Wiley & Sons, Ltd.
Cooper
Stephen J
SJ
Department of Mental Health, Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland.
Kelly
Christopher B
CB