title: Duplicating dangerously: linking centrosome duplication and aneuploidy.
abstract: Centrosomes are far more fascinating than the first explorers of this organelle a century ago could ever have imagined. Recent evidence indicates that deregulation of centrosome duplication affects centrosome number and promotes aneuploidy, features characteristic of human tumors.
authors.affiliation: Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Doxsey
mesh_terms: D000782:Aneuploidy; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D018385:Centrosome / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins