Migrating colonic crypt epithelial cells: primary targets for transformation.
It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.
Lamprecht
Sergio A
SA
Strang Cancer Research Laboratory at the Rockerfeller University, 1230 York Avenue, New York, NY 10021, USA. lampres@mail.rockefeller.edu
Lipkin
Martin
M
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000236:Adenoma / Q000235:genetics / Q000473:pathology*; D025601:Adenomatous Polyposis Coli Protein / Q000502:physiology; D000818:Animals; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology*; D004847:Epithelial Cells / Q000166:cytology; D017491:Genes, APC; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology*; D008954:Models, Biological
D025601:Adenomatous Polyposis Coli Protein