[Clinico-morphological and molecular-genetic correlations in the stomach pathology associated with Helicobacter pylori].
Some clinicomorphological correlations are made in Helicobacter pylori (H. pylori) associated diseases of the gastroduodenal zone. Genes vacA and cagA in the H. pylori genome were revealed by PCR in stomach biopsies of infected patients and the results were compared with histological changes in the patients' mucous membrane. Specific IgG antibodies to some H. pylori antigens were detected in the serum and a comparative analysis of serological and histological data was performed. The findings suggest that H. pylori associated gastroduodenal pathology is determined by interaction between macro- and microorganisms taking account of genetic characteristics of the infective microorganism, its phenotypic variations and properties of inflammatory and immune response of the host.
Chukov
S Z
SZ
Medical Academy, 355017, Stavropol.
Morozov
I A
IA
Pasechnikov
V D
VD
D000942:Antigens, Bacterial / Q000276:immunology; D015153:Blotting, Western; D004381:Duodenal Ulcer / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology / Q000473:pathology*; D016480:Helicobacter pylori / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016133:Polymerase Chain Reaction; D012703:Serotyping; D013276:Stomach Ulcer / Q000209:etiology / Q000276:immunology / Q000473:pathology*
D000942:Antigens, Bacterial