title: Multiple factors analysis on liver metastasis from colorectal cancer.
abstract: OBJECTIVE
  To investigate the clinical factors related with liver metastasis from colorectal cancer.
  
  
  METHODS
  1 312 colorectal cancer patients treated from 1988 to 1997 were collected to set up the database. Binary and multinomial logistic regression (SPSS 10.0 for windows) and then correlation analysis were used to evaluate the factors concerned.
  
  
  RESULTS
  Sex, disease course, gross tumor type, differentiation degree, pathological grade, infiltration depth and lymph node metastasis were related with liver metastasis by single factor analysis. Only sex, infiltration depth and lymph node metastasis were related with liver metastasis by multiple factor analysis. More male than female were observed in patients with liver metastasis from colorectal cancer (1.9:1, P = 0.006). Liver metastasis in colorectal cancer was positively related to the infiltration depth into the intestine wall (r = 0.926, P = 0.024). However, the correlation between the distance of lymph node metastasis and liver metastasis in colorectal cancer had no statistical significance (r = 0.748, P = 0.252).
  
  
  CONCLUSIONS
  Sex, depth of infiltration and lymph node metastasis are the main clinical factors related with liver metastasis from colorectal cancer. Male colorectal cancer patients are apt to develop liver metastasis. The deeper the tumor infiltrates, the more the liver metastasis. Age, blood type, symptoms, course, complications, tumor size and site are not related with liver metastasis in colorectal carcinoma.
authors.affiliation: Department of Abdominal Surgery, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Zhang
authors.forename: Desen
authors.initials: D
authors.lastname: Wan
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Pan
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Zhou
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Lu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Wu
authors.forename: Liren
authors.initials: L
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged