title: Renal responses to desflurane and isoflurane in patients with renal insufficiency.
abstract: BACKGROUND
  The most consistent risk factor for postoperative renal failure is poor preoperative renal function. Desflurane is not contraindicated in patients with renal disease, but the data regarding its effects on renal function in these patients are sparse.
  
  
  METHODS
  Only patients with preexisting renal disease were recruited into the study. In 51 adults undergoing elective surgery, general anesthesia was maintained using randomly desflurane or isoflurane according to a standardized protocol. Creatinine, creatinine clearance, and blood urea nitrogen were measured pre- and postoperatively.
  
  
  RESULTS
  The administered amounts of the inhaled anesthetic agents were 1.8 +/- 2.1 minimum alveolar concentration hours (mean +/- SD) of isoflurane (24 patients) and 2.2 +/- 1.8 minimum alveolar concentration hours of desflurane (27 patients), respectively. No deterioration in renal parameters was noted when comparing the pre- and postoperative values between the groups and within the groups over time.
  
  
  CONCLUSIONS
  General anesthesia with desflurane or isoflurane did not aggravate renal impairment in patients with preexisting renal insufficiency.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Carl-Gustav-Carus University Hospital, Dresden, Germany.
authors.forename: Rainer J
authors.initials: RJ
authors.lastname: Litz
authors.forename: Matthias
authors.initials: M
authors.lastname: Hübler
authors.forename: Wolfram
authors.initials: W
authors.lastname: Lorenz
authors.forename: Volker K
authors.initials: VK
authors.lastname: Meier
authors.forename: D Michael
authors.initials: DM
authors.lastname: Albrecht
mesh_terms: D000328:Adult; D000368:Aged; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D003404:Creatinine / Q000493:pharmacokinetics; D000077335:Desflurane; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000503:physiopathology*
chemical_list: D018685:Anesthetics, Inhalation; D003404:Creatinine; D000077335:Desflurane; D007530:Isoflurane