title: Direct determination of ranitidine and famotidine by CE in serum, urine and pharmaceutical formulations.
abstract: A simple and sensitive capillary electrophoresis method using UV detection has been developed for the direct determination of ranitidine (RANT) and famotidine (FAMT) in serum, urine and pharmaceutical formulations. A buffer consisting of 60 mM phosphate buffer adjusted to pH 6.5 was found to provide a very efficient and stable electrophoretic system for the analysis of both drugs. The detection limits obtained were 0.088 microgram ml(-1) for RANT and 0.16 microgram ml(-1) for FAMT.
authors.affiliation: Faculty of chemistry, Department of Analytical Chemistry, University of Murcia, 30071, Murcia, Spain, tpr@fcu.um.es
authors.forename: Tomás
authors.initials: T
authors.lastname: Pérez-Ruiz
authors.forename: C
authors.initials: C
authors.lastname: Martinez-Lozano
authors.forename: V
authors.initials: V
authors.lastname: Tomás
authors.forename: E
authors.initials: E
authors.lastname: Bravo
authors.forename: R
authors.initials: R
authors.lastname: Galera
mesh_terms: D002626:Chemistry, Pharmaceutical; D019075:Electrophoresis, Capillary / Q000379:methods; D015738:Famotidine / Q000097:blood* / Q000737:chemistry / Q000652:urine*; D011899:Ranitidine / Q000097:blood* / Q000737:chemistry / Q000652:urine*
chemical_list: D015738:Famotidine; D011899:Ranitidine