SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis.
SNOMAD is a collection of algorithms for the normalization and standardization of gene expression datasets derived from diverse biological and technological sources. In addition to conventional transformations and visualization tools, SNOMAD includes two non-linear transformations which correct for bias and variance which are non-uniformly distributed across the range of microarray element signal intensities: (1). Local mean normalization; and (2). Local variance correction (Z-score generation using a locally calculated standard deviation).
Colantuoni
Carlo
C
Department of Neurology, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA.
Henry
George
G
Zeger
Scott
S
Pevsner
Jonathan
J
D000465:Algorithms; D003195:Computer Communication Networks; D003628:Database Management Systems; D030561:Databases, Nucleic Acid; D020869:Gene Expression Profiling / Q000379:methods* / Q000592:standards; D005786:Gene Expression Regulation; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D008957:Models, Genetic; D015233:Models, Statistical; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods* / Q000592:standards; D017422:Sequence Analysis, DNA / Q000379:methods* / Q000592:standards; D012984:Software