PSF and p54(nrb)/NonO--multi-functional nuclear proteins.
Proteins are often referred to in accordance with the activity with which they were first associated or the organelle in which they were initially identified. However, a variety of nuclear factors act in multiple molecular reactions occurring simultaneously within the nucleus. This review describes the functions of the nuclear factors PSF (polypyrimidine tract-binding protein-associated splicing factor) and p54(nrb)/NonO. PSF was initially termed a splicing factor due to its association with the second step of pre-mRNA splicing while p54(nrb)/NonO was thought to participate in transcriptional regulation. Recent evidence shows that the simplistic categorization of PSF and its homolog p54(nrb)/NonO to any single nuclear activity is not possible and in fact these proteins exhibit multi-functional characteristics in a variety of nuclear processes.
Shav-Tal
Yaron
Y
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.
Zipori
Dov
D
D000818:Animals; D002256:Carbonic Anhydrases / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004261:DNA Replication; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D009369:Neoplasms / Q000209:etiology; D009687:Nuclear Proteins / Q000502:physiology*; D000072670:PTB-Associated Splicing Factor; D012313:RNA / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D016601:RNA-Binding Proteins / Q000502:physiology*; D000068103:Serine-Arginine Splicing Factors; D014158:Transcription, Genetic
D009687:Nuclear Proteins; D000072670:PTB-Associated Splicing Factor; D016601:RNA-Binding Proteins; C101745:Sfrs11 protein; D000068103:Serine-Arginine Splicing Factors; D012313:RNA; D002256:Carbonic Anhydrases