title: Asymmetric intramolecular [3 + 2] cycloaddition reactions of acylhydrazones/olefins using a chiral zirconium catalyst.
abstract: Catalytic asymmetric intramolecular [3 + 2] cycloaddition of hydrazone/olefins has been attained. In the presence of a chiral zirconium catalyst prepared from zirconium alkoxide and a BINOL derivative, the desired pyrazolidine derivatives were obtained in high yields with high selectivities. The products were easily converted to 1,3-diamine or beta-aminonitrile derivatives by N-N bond cleavage.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 Japan. skobayas@mol.f.u-tokyo.ac.jp
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Haruka
authors.initials: H
authors.lastname: Shimizu
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Haruro
authors.initials: H
authors.lastname: Ishitani
authors.forename: Jun
authors.initials: J
authors.lastname: Kobayashi