Study on the relationship between opioid receptors and fetal distress.
OBJECTIVE
To evaluate the role of opioid receptors in the fatal distress.


METHODS
Pregnant near-term rabbits were given an intravenous dose of normal saline solution or the opiate antagonist beta-FNA and ICI and then asphyxiated. The rabbit fetus were delivered by cesarean section and evaluated for respiration, heart beat, color, muscle tone, and response to stimulation at 1, 5, 10, 15, and 30 minutes of age.


RESULTS
The FNA-treated pups (6.8 +/- 1.7) and the ICI-treated pups (4.9 +/- 0.7) had significantly better scores than the saline-treated pups (2.5 +/- 1.1) and the fetal distress group (2.1 +/- 1.0, P < 0.01 and P < 0.05); there was no statistical difference between the saline group and the non treated pups (P > 0.05). The Apgar scores in ICI group, saline group, and fetal distress group were significantly decreased than that in control group (P < 0.01 and P < 0.05); Scores of all five subjects could be raised markedly in FNA group, there was no significant difference in the FNA-treated pups and the control group (P > 0.05).


CONCLUSIONS
These results suggested that both mu- and delta- receptors participated in conducting the endogenous opioid peptides effect, it was associated with the pathophysiological changes in fetal distress; mu- receptor was much more important between the two.
Hu
Dian
D
Department of Obstetrics and Gynecology, Affiliated Changzheng Hospital of the Second Military Medical University, Shanghai 200003, China.
Gu
Hang
H
Hong
Xinru
X
Liu
Yan
Y
Wang
Chenghai
C
Cao
Liping
L
Li
Ping
P
D000818:Animals; D002585:Cesarean Section; D005316:Fetal Distress; D006801:Humans; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta