title: Current perspectives in cancer proteomics.
abstract: Proteome technology has been used widely in cancer research and is a useful tool for the identification of new cancer markers and treatment-related changes in cancer. This article details the use of proteome technology in cancer research, and laboratory-based and clinical cancer research studies are described. New developments in proteome technology that enable higher sample-throughput are evaluated and methods for enhancing conventional proteome analysis (based on two-dimensional electrophoresis) discussed. The need to couple laboratory-based proteomics research with clinically relevant models of the disease is also considered, as this remains the next main challenge of cancer-related proteome research.
authors.affiliation: Breast Cancer Research Group, Department of Surgery, Royal Free and University College London Medical School, Institute of Surgical Studies, UK. m.dwek@ucl.ac.uk
authors.forename: Miriam V
authors.initials: MV
authors.lastname: Dwek
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Rawlings
mesh_terms: D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D020543:Proteome; D012307:Risk Factors; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D020543:Proteome