title: Improved detection of liver metastases with contrast-enhanced wideband harmonic imaging: comparison with CT findings.
abstract: OBJECTIVE
  To evaluate the capability of contrast-enhanced wideband harmonic imaging (WHI) to detect liver metastases in comparison with fundamental B-mode US and postcontrast CT.
  
  
  METHODS
  We studied 27 patients with hepatic metastases from different malignancies with conventional B-mode sonography, WHI 3 min after injection of contrast agent (Levovist(R) 2.5 g, 300 mg/ml) and postcontrast helical CT (HCT). The number and location of the lesions and the smallest lesion for each patient were noted by two different observers and compared.
  
  
  RESULTS
  Both readers recorded an increase in the number of lesions in harmonic mode compared with conventional B-mode in all 27 patients with hepatic metastases with a mean increase in both observers from 9.3 lesions with B-mode to 18.8 lesions with WHI. The smallest lesions were detected with WHI when compared with conventional US and HCT (2 mm with WHI, 5 mm with B-mode and 5 mm with CT). WHI detected more lesions than conventional US or HCT.
  
  
  CONCLUSIONS
  Contrast-enhanced WHI seems superior to conventional US and HCT for the detection of hepatic metastases, specially for those nodules under 1 cm of diameter.
authors.affiliation: Department of Radiology, Hospital Clínico Universitario, Paseo de la Pechina, 137, 16a, 46008, Valencia, Spain. esteban_jma@hotmail.com
authors.forename: J M
authors.initials: JM
authors.lastname: Esteban
authors.forename: M A
authors.initials: MA
authors.lastname: Mollá
authors.forename: C
authors.initials: C
authors.lastname: Tomás
authors.forename: L
authors.initials: L
authors.lastname: Maldonado
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000008:administration & dosage*; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508