In vivo neurochemical monitoring by microdialysis and capillary separations.
Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis. These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery.
Kennedy
Robert T
RT
Department of Chemistry and Pharmacology, 930 North University, University of Michigan, Ann Arbor 48109-1055, USA. rtkenn@umich.edu
Watson
Christopher J
CJ
Haskins
William E
WE
Powell
David H
DH
Strecker
Robert E
RE
D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D019075:Electrophoresis, Capillary; D006801:Humans; D017551:Microdialysis; D009479:Neuropeptides / Q000032:analysis / Q000737:chemistry; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
D009479:Neuropeptides