title: Cytokines: promoters and dampeners of autoimmunity.
abstract: Cytokines are the co-ordinators of the immune system and, as such, are important targets for immunomodulation. Progress has been made towards the use of IL-10 for immunosuppressive therapy to prevent autoimmunity. Interest has also recently focused on the role of cytokines in controlling the activation of dendritic cells and NK cells, and the consequences of this for the development of autoaggressive responses. Genes involved in IFN-activated pathways that control the survival of lymphocytes have been strongly linked to lupus susceptibility, and IFN-mediated defenses against viral infection have been shown to determine susceptibility to a model of viral-induced diabetes.
authors.affiliation: The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Hill
authors.forename: Nora
authors.initials: N
authors.lastname: Sarvetnick
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology*; D016207:Cytokines / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology; D016753:Interleukin-10 / Q000502:physiology; D019409:Interleukin-15 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D051379:Mice; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D016207:Cytokines; D019409:Interleukin-15; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma