title: Eudragit NE30D based metformin/gliclazide extended release tablets: formulation, characterisation and in vitro release studies.
abstract: Metformin/Gliclazide extended release tablets were formulated with Eudragit NE30D by wet granulation technique. Two batches were prepared in order to study influence of drug polymer ratio on the tablet formation and in vitro drug release. The formulated tablets were characterized by disintegration time, hardness, friability, thickness, weight variation, and in vitro drug release. The percentage of polymer, with respect to Metformin/Gliclazide, required to produce tablets with acceptable qualities was 9 to 13.45. The percentage of polymer below this range released the drug immediately and above this range produced granules not suitable for tablet formation. The quantity of Metformin/Gliclazide present in the tablets and the release medium were estimated by a validated HPLC method. The formulated tablets had acceptable physicochemical characters and released the drug over 6-8 h. The data obtained from in vitro release studies were fitted with various kinetic models and was found to follow Higuchi kinetics.
authors.affiliation: Department of Pharmaceutics, Vel's College of Pharmacy, Old Pallavaram, Chennai, India.
authors.forename: Enose Appavoo
authors.initials: EA
authors.lastname: Arno
authors.forename: Prithiviraj
authors.initials: P
authors.lastname: Anand
authors.forename: Kesavan
authors.initials: K
authors.lastname: Bhaskar
authors.forename: Somasundaram
authors.initials: S
authors.lastname: Ramachandran
authors.forename: Muniyandy
authors.initials: M
authors.lastname: Saravanan
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Vinod
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics; D005907:Gliclazide / Q000493:pharmacokinetics*; D008687:Metformin / Q000493:pharmacokinetics*; D011109:Polymethacrylic Acids / Q000493:pharmacokinetics*; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D008687:Metformin; D005907:Gliclazide