Interleukin-6-producing thymic squamous cell carcinoma associated with Castleman's disease and nephrotic syndrome.
When a 63-year-old man was hospitalized with nephrotic syndrome due to focal segmental glomerulosclerosis, a mediastinal mass was discovered. A biopsy specimen obtained by mediastinoscopy showed findings compatible with the plasma cell type of Castleman's disease. Fever, anemia, and anti-nuclear antibody were present. Serum concentrations of gamma globulin, acute phase proteins, and, most strikingly, interleukin-6 (IL-6) were elevated. Methylprednisolone pulse therapy resulted in no clinical improvement. Pathologic examination of the resected thymic tumor showed a squamous cell carcinoma immunoreactive for IL-6. To our knowledge, this case represents the first reported IL-6-producing thymic squamous cell carcinoma associated with Castleman's disease and nephrotic syndrome.
Matsumura
Norihiko
N
Department of Internal Medicine, Nara Prefectural Mimuro Hospital, Kitakatsuragi-gun.
Shiiki
Hideo
H
Saito
Naotoshi
N
Uramoto
Hiroki
H
Hanatani
Masakazu
M
Nonaka
Hideo
H
Nakamura
Shinobu
S
D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005871:Castleman Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D010950:Plasma Cells / Q000502:physiology; D013902:Radiography, Thoracic; D013953:Thymus Neoplasms / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
D015850:Interleukin-6