Phosphatidylinositol 3,5-bisphosphate: metabolism and function.
Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P(2)) is the most recently discovered PtdInsP(2) isomer. It is likely that PtdIns(3,5)P(2) is ubiquitous to eukaryotes, and that it performs a number of important cellular functions, including vacuolar homeostasis, retrograde trafficking from the vacuole, and protein sorting at the multivesicular body. This review describes the metabolism of PtdIns(3,5)P(2) and discusses the potential functions for this lipid.
Cooke
Frank T
FT
Department of Biochemistry and Molecular Biology, University of College, London, Darwin Building, Gower Street, London, UK. f.cooke@ucl.ac.uk
D000818:Animals; D008956:Models, Chemical; D010641:Phenotype; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism* / Q000502:physiology*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry / Q000502:physiology; D017434:Protein Structure, Tertiary; D029701:Saccharomyces cerevisiae Proteins
D018129:Phosphatidylinositol Phosphates; D029701:Saccharomyces cerevisiae Proteins; C106336:phosphatidylinositol 3,5-diphosphate; C095504:FAB1 protein, S cerevisiae; D017853:Phosphotransferases (Alcohol Group Acceptor)