title: A flexible strategy for the divergent modification of pleuromutilin.
abstract: The complex antibacterial natural product, pleuromutilin, can be directly modified by the radical addition reaction of various xanthates to the unactivated terminal olefin present on C-12.
authors.affiliation: Aventis, Centre de Recherche de Romainville, 102 Route de Noisy, F-93235 Romainville, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Bacqué
authors.forename: François
authors.initials: F
authors.lastname: Pautrat
authors.forename: Samir Z
authors.initials: SZ
authors.lastname: Zard
mesh_terms: D000577:Amides; D000900:Anti-Bacterial Agents / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry*; D015195:Drug Design; D004952:Esters; D011083:Polycyclic Compounds; D000097567:Pleuromutilins
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D004952:Esters; D011083:Polycyclic Compounds; D000097567:Pleuromutilins