title: A study of the ultrastructure and gene location of hereditary gingival fibromatosis.
abstract: OBJECTIVE
  To ascertain histology changes of hereditary gingival fibromatosis (HGF) and the location of HGF gene.
  
  
  METHODS
  A pedigree analyses of HGF; and the ultrastructure of gingival overgrowth tissue was observed with electron microscopy. The overgrowth of the HGF gene was defined with microsatellite markers.
  
  
  RESULTS
  The connective tissue of HGF consisted of coarse collagen bundles and several kinds of cells arranged abnormally, such as: epithelial cells, smooth muscle cells and so on; the HGF locus had been mapped to chromosome 5q13-q22.
  
  
  CONCLUSIONS
  The gingival pathologic changes resemble "hamartoma"; the findings has implications for identification of the underlying genetic basis of HGF.
authors.affiliation: Department of Periodontology, Affiliated Stomatological Hospital, Medical College of Nanjing University, Nanjing 210008, China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Yang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Zhang
authors.forename: Shangxi
authors.initials: S
authors.lastname: Xiao
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Huang
authors.forename: Jilie
authors.initials: J
authors.lastname: Zheng
authors.forename: Xiangyin
authors.initials: X
authors.lastname: Kong
mesh_terms: D002648:Child; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005192:Family Health; D005260:Female; D005351:Fibromatosis, Gingival / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005881:Gingiva / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008854:Microscopy, Electron; D010375:Pedigree