title: Influence of normal ageing on mechanism of bone loss in women and men in Bangkok.
abstract: Age and sex related changes in bone metabolism are of interest in the pathogenesis of osteoporosis. However, most data in the literature were studied in Western countries. In a tropical country, such as Thailand, little is known of vitamin D status and bone remodeling. Thus, the aim of this study was to determine the changes of vitamin D levels and biochemical markers of bone turnover in healthy women and men of various age groups between 20-80 years who were living in Bangkok. From the results, vitamin D levels of various age groups did not alter significantly between men and women except in the sixth decade of women. However, men had higher levels of vitamin D than women. In women, all biochemical markers of bone turnover increased with age, with a sharp increase at the onset of menopause. In contrast, biochemical markers of bone turnover in men gradually declined with advancing age.
  
  
  CONCLUSIONS
  There was no evidence of vitamin D deficiency in the Bangkok population. Women and men showed different age-related changes in bone metabolism.
authors.affiliation: Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: La-Or
authors.initials: LO
authors.lastname: Chailurkit
authors.forename: Noppawan
authors.initials: N
authors.lastname: Piaseu
authors.forename: Rajata
authors.initials: R
authors.lastname: Rajatanavin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013785:Thailand; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000453:epidemiology
chemical_list: D014807:Vitamin D