Glutathione-dependent system of antioxidant defense in the placenta in preterm delivery.
Components of the antioxidant defense system in placental tissues were studied in women with normal pregnancy and full-term delivery and women with spontaneous abortions at 28-36 weeks. In women with spontaneous abortions glutathione peroxidase activity in placental tissues increased and the content of SH compounds decreased, which led to exhaustion of the antioxidant defense system. Glutathione-S-transferase activity also decreased, which attests to impaired detoxifying function of the placenta.
Prokopenko
V M
VM
D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg.
Partsalis
G K
GK
Pavlova
N G
NG
Burmistrov
S O
SO
Arutyunyan
A V
AV
D000022:Abortion, Spontaneous; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000096:biosynthesis*; D005982:Glutathione Transferase / Q000096:biosynthesis*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D013438:Sulfhydryl Compounds; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione