Genetic improvement of plant for coeliac disease.
Wheat, rye and barley are toxic for patients with coeliac disease. Toxicity has been found to result, respectively, from proteins such as gliadins, secalins and hordeins. Agglutination of in vitro cultured human myelogenous leukaemia K 562 (S) cells proved to be a suitable model for detection of toxic components of proteins. Five toxic peptides derived from an A-gliadin protein have been found to agglutinate the K 565 (S) cells. Triticum monococcum is a diploid wheat species widely grown during the Bronze Age. Proteins from monococcum are unable to agglutinate the K 562 (S) cells.
Pogna
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Institute for Cereal Research, Rome, Italy. pognaroberto@mclink.it
D002446:Celiac Disease / Q000178:diet therapy / Q000209:etiology; D005903:Gliadin; D005983:Glutens; D006801:Humans; D010940:Plant Proteins; D014908:Triticum; D014407:Tumor Cells, Cultured
D010940:Plant Proteins; D005983:Glutens; D005903:Gliadin