title: Straightforward entry into 5-hydroxy-1-aminopyrrolines and the corresponding pyrroles from 1,2-diaza-1,3-butadienes.
abstract: The synthesis of 5-hydroxy-1-aminopyrroline-3-carboxylic acid derivatives and 5-unsubstituted-1-aminopyrrole-3-carboxylic acid derivatives from 1,2-diaza-1,3-butadienes and aldehydes is presented. These domino reactions offer the advantage of executing multistep transformation without intermediate workup procedures. The stereoselectivity of ring closure to 5-hydroxy-1-aminopyrroline-3-carboxylic acid derivatives and phenyl transposition to 2,3-diphenyl-1-aminopyrrole-3-carboxylic acid derivatives are also studied.
authors.affiliation: Istituto di Chimica Organica, Università di Urbino, Piazza della Repubblica 13, 61029 Urbino, Italy.
authors.forename: Orazio A
authors.initials: OA
authors.lastname: Attanasi
authors.forename: Lucia
authors.initials: L
authors.lastname: de Crescentini
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Favi
authors.forename: Paolino
authors.initials: P
authors.lastname: Filippone
authors.forename: Fabio
authors.initials: F
authors.lastname: Mantellini
authors.forename: Stefania
authors.initials: S
authors.lastname: Santeusanio