Aspergillus osteomyelitis after liver transplantation.
A 57-year-old woman underwent liver transplantation and developed osteomyelitis in the femur attributable to Aspergillus fumigatus. The patient was treated successfully with amphotericin B and 5-fluorocytosine for 30 days, and then switched to itraconazole for 12 months. Plasma (1->3)-beta-D-glucan levels decreased significantly after the chemotherapy. Early diagnosis by (1->3)-beta-D-glucan measurement and extended treatment with itraconazole can improve the prognosis of invasive Aspergillus infection.
Kaneko
Junichi
J
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Sugawara
Yasuhiko
Y
Makuuchi
Masatoshi
M
D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy; D001232:Aspergillus fumigatus; D005260:Female; D005269:Femur / Q000382:microbiology / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010019:Osteomyelitis / Q000097:blood / Q000175:diagnosis / Q000382:microbiology*; D011509:Proteoglycans / Q000097:blood; D018125:Receptors, Transforming Growth Factor beta / Q000097:blood
D000935:Antifungal Agents; D011509:Proteoglycans; D018125:Receptors, Transforming Growth Factor beta; C071736:betaglycan; D017964:Itraconazole