4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor.
A new fluorescent ligand for adenosine receptors, obtained by the insertion of a dansylamino-moiety with a linear hexyl spacer in the N4 position of a 1,8-naphthyridine adenosine receptor ligand, proved to possess a high affinity and selectivity for the A1 receptor subtype.
Macchia
Marco
M
Dipartimento di Scienze Farmaceutiche, Università di Pisa, Italy. mmacchia@farm.unipi.it
Bertini
Simone
S
Di Bussolo
Valeria
V
Manera
Clementina
C
Martini
Claudia
C
Minutolo
Filippo
F
Mori
Claudio
C
Saccomanni
Giuseppe
G
Tuscano
Daniela
D
Ferrarini
Pier Luigi
PL
D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003619:Dansyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009287:Naphthyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011869:Radioligand Assay; D018047:Receptors, Purinergic P1 / Q000737:chemistry / Q000378:metabolism*
C473766:4-(6-(dansylamino)hexylamino)-7-methyl-2-phenyl-1,8-naphthyridine; D003619:Dansyl Compounds; D005456:Fluorescent Dyes; D009287:Naphthyridines; D018047:Receptors, Purinergic P1