title: Cannabidiol: an overview of some pharmacological aspects.
abstract: Over the past few years, considerable attention has focused on cannabidiol (CBD), a major nonpsychotropic constituent of cannabis. The authors present a review on the chemistry of CBD and discuss the anticonvulsive, antianxiety, antipsychotic, antinausea, and antirheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors, and its mechanism of action is yet unknown. It is possible that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its antioxidative effect.
authors.affiliation: Deportment of Medicinal Chemistry and Natural Products, Hebrew University of Jerusalem, Israel.
authors.forename: Raphael
authors.initials: R
authors.lastname: Mechoulam
authors.forename: Linda A
authors.initials: LA
authors.lastname: Parker
authors.forename: Ruth
authors.initials: R
authors.lastname: Gallily
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D000932:Antiemetics / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D002185:Cannabidiol / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D009325:Nausea / Q000517:prevention & control
chemical_list: D014151:Anti-Anxiety Agents; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000932:Antiemetics; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D002185:Cannabidiol