7-Methoxy-1H-indazole, a new inhibitor of neuronal nitric oxide synthase.
The crystal structure of 7-methoxy-1H-indazole, C(8)H(8)N(2)O, an inhibitor of nitric oxide synthase, shows that the methoxy group lies in the plane of the indazole system with its methyl group located trans to the indazole N-H group. The crystal packing consists principally of hydrogen-bonded trimers. Intermolecular hydrogen-bonding interactions are formed between the indazole N atoms, with the N-H group as a hydrogen-bond donor and the remaining N atom as an acceptor.
Sopková-de Oliveira Santos
Jana
J
Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen, 5 Rue Vaubénard, 14032 Caen, France. sopkova@pharmacie.unicaen.fr
Collot
Valérie
V
Rault
Sylvain
S
D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D007191:Indazoles / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I
C436345:7-methoxyindazole; D004791:Enzyme Inhibitors; D007191:Indazoles; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I