title: [Colicinogenic activity of intestinal microflora as a sign of dysbacteriosis of the gastrointestinal tract].
abstract: Clinical and bacteriological studies have revealed that the production of colicin by Escherichia coli forming a part of intestinal microbiocenosis is related to the clinical manifestations of inflammatory diseases of the gastrointestinal tract. During the exacerbation of chronic inflammatory processes of the digestive system the proportion of colicin producing E. coli increases (more than 45%) in comparison with that of E. coli fecal strains isolated in children and adolescents regarded as healthy (less than 15%). The possibility of using the colicin producing activity of intestinal microflora for the evaluation of the dysbiotic states of gastrointestinal tract is discussed.
authors.affiliation: Institute of Cellular and Intracellular Symbiosis of the Urals Branch, Russian Academy of Sciences, Medical Academy, Orenburg, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
authors.forename: A V
authors.initials: AV
authors.lastname: Valyshev
authors.forename: O E
authors.initials: OE
authors.lastname: Chelpachenko
authors.forename: N N
authors.initials: NN
authors.lastname: Elagina
authors.forename: N B
authors.initials: NB
authors.lastname: Perunova
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002908:Chronic Disease; D003087:Colicins / Q000032:analysis / Q000096:biosynthesis*; D004064:Digestive System / Q000382:microbiology*; D004926:Escherichia coli / Q000302:isolation & purification* / Q000378:metabolism; D005243:Feces / Q000382:microbiology*; D005759:Gastroenteritis / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D012008:Recurrence
chemical_list: D015415:Biomarkers; D003087:Colicins