title: Synthetic lethality: killing cancer with cancer.
authors.forename: Ken
authors.initials: K
authors.lastname: Garber
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001549:Benzamides; D016227:Benzoquinones; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D000077156:Gefitinib; D016147:Genes, Tumor Suppressor / Q000187:drug effects*; D018841:HSP90 Heat-Shock Proteins / Q000187:drug effects / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D007211:Indoles / Q000494:pharmacology; D047029:Lactams, Macrocyclic; D009154:Mutation / Q000187:drug effects*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000187:drug effects / Q000235:genetics; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology; D017828:Rifabutin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000494:pharmacology; D014157:Transcription Factors / Q000187:drug effects; D025521:Tumor Suppressor Proteins / Q000187:drug effects / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D016227:Benzoquinones; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D018841:HSP90 Heat-Shock Proteins; D007211:Indoles; D047029:Lactams, Macrocyclic; D010879:Piperazines; D011743:Pyrimidines; D011758:Pyrroles; D011799:Quinazolines; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D017828:Rifabutin; C112765:tanespimycin; C401859:temsirolimus; C116890:Semaxinib; D000068877:Imatinib Mesylate; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D000077156:Gefitinib; D020123:Sirolimus