Microwave-assisted (radio)halogenation of nitroimidazole-based hypoxia markers.
Microwave-assisted radiohalogenation for the production of short-lived radiopharmaceuticals has now been applied to the synthesis and radiolabelling of azomycin nucleosides. (Radio)halogens were incorporated either by nucleophilic substitution of a leaving group or by halogen-halogen exchange, in the synthesis of IAZA, IAZP and FAZA. A comparison of conventional labelling and microwave-assisted labelling procedures reflects a clear advantage of the microwave technique.
Kumar
P
P
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Wiebe
L I
LI
Asikoglu
M
M
Tandon
M
M
McEwan
A J B
AJ
D015415:Biomarkers; D006358:Hot Temperature; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D008872:Microwaves; D009593:Nitroimidazoles / Q000138:chemical synthesis*; D011854:Radiochemistry / Q000379:methods; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D015415:Biomarkers; D007457:Iodine Radioisotopes; D009593:Nitroimidazoles; D019275:Radiopharmaceuticals