title: Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor.
abstract: Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction).
authors.affiliation: Department of Pathophysiology, Kursk State Medical University. big@ksmu.kursknet.ru
authors.forename: M Yu
authors.initials: MY
authors.lastname: Smakhtin
authors.forename: L A
authors.initials: LA
authors.lastname: Sever'yanova
authors.forename: A I
authors.initials: AI
authors.lastname: Konoplya
authors.forename: I A
authors.initials: IA
authors.lastname: Shveinov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007116:Immunization, Passive; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D008940:Mitotic Index; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007166:Immunosuppressive Agents; D009842:Oligopeptides; C020905:glycyl-histidyl-lysine