title: Fundamental issues, recent advances, and future directions in myodynamics.
abstract: A state-of-the-art report is presented on recent progress in selected areas of myodynamics, but also on problems that severely hamper the further development of the discipline. Significant advances have been made in elucidating the force-producing interaction between actin and the myosin-S1-subunit, including the localization of the most probable molecular site of power stroke initiation. Concerning the architecture of the myostructures, strong experimental evidence has accumulated for numerous intra-, inter-, and extramuscular pathways for lateral force transmission in addition to the serial sarcomere-to-sarcomere myotendinous path. It is shown that contemporary muscle models are inadequate in most respects and lag far behind the requirements an appropriate myodynamic model should fulfil. A similar comment applies to the current approaches designed to solve the myoskeletal indeterminacy problem. These formulations neglect myodynamic properties and do not allow for the implementation of biologically realistic objective functions. The solutions currently obtained are highly unsatisfactory. New research directions to rectify these situations are suggested, also with regard to the identification of subject-specific myodynamic parameters.
authors.affiliation: Department of Biomechanics, University of Vienna, Auf der Schmelz 6, A-1150 Wien, Austria. herbert.hatze@univie.ac.at
authors.forename: H
authors.initials: H
authors.lastname: Hatze
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D004550:Elbow / Q000502:physiology; D005544:Forecasting; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009218:Myosins / Q000502:physiology*
chemical_list: D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D009218:Myosins