Animal models for studying lung cancer and evaluating novel intervention strategies.
The pathogenesis of lung cancer progression, invasion and metastasis remains undefined. Clinically relevant laboratory models of the disease could greatly facilitate its clarification. Model systems of lung cancer that accurately reflect different biologic properties and disease stages are necessary to ensure proper experimental design of studies aimed at increasing our understanding of the disease. Such models are also essential tools to accelerate development of new therapies for lung cancer. In this review we summarize the available lung cancer model systems in use today and define both their utility and limitations.
Liu
Jiang
J
Department of Thoracic Surgery, Toronto General Hospital, Division of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Ont., Canada.
Johnston
Michael R
MR
D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology / Q000628:therapy*; D051379:Mice; D051381:Rats