IRES elements: features of the RNA structure contributing to their activity.
The activity of internal ribosome entry site (IRES) elements depends on their structural organization. We have addressed here the study of conserved structural motifs in the foot-and-mouth disease virus (FMDV) IRES as an example to understand the relationship between RNA structure and function. The features of the RNA structure known to be functionally relevant are discussed in regards to the capacity to modulate interaction of translation initiation factors with the FMDV IRES element. Additionally, the contribution of non-canonical RNA-binding proteins to FMDV IRES organization as well as stimulation of its activity by other mRNA regions is discussed.
Martínez-Salas
Encarnación
E
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain. emartinez@cbm.uam.es
López de Quinto
Sonia
S
Ramos
Ricardo
R
Fernández-Miragall
Olga
O
D001483:Base Sequence; D001665:Binding Sites; D017124:Conserved Sequence / Q000235:genetics; D029544:Foot-and-Mouth Disease Virus / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010448:Peptide Initiation Factors / Q000378:metabolism; D017354:Point Mutation; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship
D010448:Peptide Initiation Factors; D012333:RNA, Messenger; D012367:RNA, Viral; D016601:RNA-Binding Proteins