Pharacine, a natural p-cyclophane and other indole derivatives from Cytophaga sp. strain AM13.1.
From the ethyl acetate extract of the bacterial strain Cytophaga sp. AM13.1, among many known compounds, the new natural products 2,5-bis(3-indolylmethyl)pyrazine (2) and a highly symmetrical p-cyclophane named pharacine (5) were identified. In addition, tryptamine isovalerate (1) and p-hydroxyphenylacetamide (4), known as plant metabolites, were isolated and characterized from a microorganism for the first time. The new natural products showed no activity against three microalgae, the fungus Mucor miehei, the yeast Candida albicans, and the bacteria Staphylococcus aureus, Bacillussubtilis, Escherichia coli, and Streptomyces viridochromogenes.
Shaaban
Mohamed
M
Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Maskey
Rajendra P
RP
Wagner-Döbler
Irene
I
Laatsch
Hartmut
H
D001412:Bacillus subtilis / Q000187:drug effects; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification*; D002176:Candida albicans / Q000187:drug effects; D003589:Cytophaga / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D056890:Eukaryota / Q000187:drug effects; D005285:Fermentation; D005858:Germany; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D011719:Pyrazines / Q000737:chemistry / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000187:drug effects; D000097566:Cyclophanes
D001555:Benzene Derivatives; D004988:Ethers, Cyclic; D007211:Indoles; D011719:Pyrazines; C471671:2,5-bis(3-indolylmethyl)pyrazine; C471669:pharacine; D000097566:Cyclophanes