Massive hepatosplenomegaly in a child with malaria.
Hypermalarial splenomegaly syndrome (HMS) usually occurs in adults living in malaria-endemic areas. A 7-year-old girl presented with a 7-week history of gradual distention of the abdomen and low grade fever, 8 months after traveling to Ghana, and was subsequently diagnosed with HMS. Presentation at such a young age after very brief exposure to a malaria-endemic area has not been described previously.
Ladhani
Shamez
S
Department of Pediatrics, Newham General Hospital, London, UK.
Dosekun
Efunbo
E
Patel
Vidya
V
Shingadia
Delane
D
D000367:Age Factors; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002648:Child; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005869:Ghana; D006529:Hepatomegaly / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology; D016778:Malaria, Falciparum / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D002727:Proguanil / Q000627:therapeutic use; D011739:Pyrimethamine / Q000627:therapeutic use; D011803:Quinine / Q000627:therapeutic use; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D013413:Sulfadoxine / Q000627:therapeutic use; D013997:Time Factors; D014195:Travel
D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011803:Quinine; D002727:Proguanil; D011739:Pyrimethamine