title: A diterpene quinone from the bark of Cryptomeria japonica.
abstract: A diterpene, cryptoquinone, was isolated from the bark of Cryptomeria japonica, the structure, 7,11,14-trioxoabieta-8,12-diene, was established by spectral analyses and X-ray crystallography. This diterpene quinone showed moderate antifungal activities against Pyricularia orizae and Alternaria alternata, and cytotoxic activity against mouse lymphoid neoplasm (P388) cells with an IC(50) of 0.26 microg/ml.
authors.affiliation: Faculty of Agriculture, Iwate University, Ueda 3-18-8, Morioka 020-8550, Japan. kofujita@iwate-u.ac.jp
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kofujita
authors.forename: Michikazu
authors.initials: M
authors.lastname: Ota
authors.forename: Kouetsu
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawai
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D032485:Cryptomeria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008223:Lymphoma / Q000473:pathology; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes; D011809:Quinones