title: The application of bioimplants in the management of chronic osteomyelitis.
abstract: The management of musculoskeletal infections is an increasing challenge to clinicians. Bioimplants provide a unique system for skeletal specific drug delivery. Antibiotic-impregnated beads and spacers can be used to treat chronic osteomyelitis and deep soft-tissue infections locally with higher antibiotic concentrations, while avoiding potential systemic side effects.
authors.affiliation: Department of Orthopedics and Rehabilitation, University of Texas Medical Branch, Galveston TX 77555-1115, USA.
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Jason H
authors.initials: JH
authors.lastname: Calhoun
authors.forename: Jon T
authors.initials: JT
authors.lastname: Mader
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D001682:Biological Availability; D001843:Bone Cements; D002908:Chronic Disease; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000601:surgery*; D019736:Prostheses and Implants; D011817:Rabbits; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014945:Wound Healing / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D020099:Coated Materials, Biocompatible