Molecular targets of anti-HIV-1 triterpenes.
Pentacyclic triterpenes have been found in many plants and may be isolated from any part of the plant. Triterpene derivatives were shown to have biological activities including anti-HIV-1 and anti-cancer activities. The modes of action of the anti-HIV-1 triterpenes have been reported to be associated with the virus entry, reverse transcription, virus assembly and maturation. This review will focus on the mechanisms of action of anti-HIV triterpenes and the structural features that contribute to their anti-HIV-1 activity and site of action.
Huang
Li
L
Department of Microbiology, Meharry Medical College, 1005 DB Todd Blvd., Nashville, TN 37208, USA.
Chen
Chin Ho
CH
D019380:Anti-HIV Agents / Q000494:pharmacology*; D017320:HIV Protease Inhibitors / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D011991:Receptors, Virus / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology*
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D011991:Receptors, Virus; D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes