[Interest in therapeutic drug monitoring of the main antibiotics].
The therapeutic drug monitoring aims at optimising the prescribed dosages to improve efficacy and prevent toxicity. The aim of this study were to review the main pharmacodynamic and pharmacokinetic properties of aminoglycosides, glycopeptides and ceftazidime. Then, the therapeutic drug monitoring of these antibiotics and their methods of analysis is reviewed.
Davani
S
S
Laboratoire de pharmacologie, CHU Jean Minjoz, 25030 Besançon, France.
Muret
P
P
Royer
B
B
Hoen
B
B
Kantelip
J-P
JP
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use / Q000633:toxicity; D002442:Ceftazidime / Q000493:pharmacokinetics; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D017334:Teicoplanin; D014640:Vancomycin / Q000493:pharmacokinetics
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D014640:Vancomycin; D002442:Ceftazidime