title: Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation.
abstract: Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane-microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton-mediated architecture of the immunological synapse that plays a role in T-cell receptor clustering, protein kinase C theta translocation and intracellular signaling.
authors.affiliation: Unité de Biologie des Interactions Cellulaires, CNRS URA 1960, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Das
authors.forename: Béatrice
authors.initials: B
authors.lastname: Nal
authors.forename: Anne
authors.initials: A
authors.lastname: Roumier
authors.forename: Vannary
authors.initials: V
authors.lastname: Meas-Yedid
authors.forename: Christophe
authors.initials: C
authors.lastname: Zimmer
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Olivo-Marin
authors.forename: Pascal
authors.initials: P
authors.lastname: Roux
authors.forename: Pierre
authors.initials: P
authors.lastname: Ferrier
authors.forename: Alice
authors.initials: A
authors.lastname: Dautry-Varsat
authors.forename: Andrés
authors.initials: A
authors.lastname: Alcover
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000276:immunology; D000199:Actins / Q000276:immunology; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D017252:CD3 Complex / Q000378:metabolism; D016764:Cell Polarity; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000276:immunology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007365:Intercellular Junctions / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D010750:Phosphoproteins / Q000737:chemistry / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D000099149:Ezrin; D054378:Acetogenins
chemical_list: D015107:4-Butyrolactone; D000199:Actins; D017252:CD3 Complex; D003598:Cytoskeletal Proteins; D010750:Phosphoproteins; D011948:Receptors, Antigen, T-Cell; D000099149:Ezrin; C438920:coronin acetogenin; D054378:Acetogenins