title: Cutaneous sclerosing extramedullary hematopoietic tumor in chronic myelogenous leukemia.
abstract: BACKGROUND
  Extramedullary hematopoiesis is a well-documented manifestation of chronic myeloproliferative disorders, most commonly seen in chronic idiopathic myelofibrosis (agnogenic myeloid metaplasia), but rarely in chronic myelogenous leukemia. It typically occurs in the spleen and liver, but has also been described in skin. Microscopically, foci of extramedullary hematopoiesis consist of erythroid and myeloid precursors intermixed with megakaryocytes. The megakaryocytes may elaborate fibrogenic cytokines, which induce proliferation of fibroblasts. The term 'sclerosing extramedullary hematopoietic tumor' has been applied to this latter entity and its resemblance to a fibrohistiocytic neoplasm has been noted.
  
  
  METHODS
  We report the case of a 66-year-old man, whose cutaneous sclerosing extramedullary hematopoietic tumor preceded the diagnosis of chronic myelogenous leukemia.
authors.affiliation: Section of Dermatology, Department of Medicine, The Medical College of Georgia, Augusta 30912, USA.
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Lane
authors.forename: Anna N
authors.initials: AN
authors.lastname: Walker
authors.forename: Anita
authors.initials: A
authors.lastname: Kulharya
authors.forename: Tomasz
authors.initials: T
authors.lastname: Marzec
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002467:Cell Nucleus / Q000473:pathology; D015726:Giant Cells / Q000378:metabolism / Q000473:pathology; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D008297:Male; D012598:Sclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D012871:Skin Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D014841:von Willebrand Factor