title: Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome.
abstract: We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with Zollinger-Ellison syndrome. There was extensive metastatic dissemination of the neuroendocrine component to regional lymph nodes and to the liver. The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed.
authors.affiliation: Department of Pathology, CHU of Liège, Sart-Tilman, 4000 Liège, Belgium. L.deLeval@ulg.ac.be
authors.forename: Laurence
authors.initials: L
authors.lastname: de Leval
authors.forename: Noëlle
authors.initials: N
authors.lastname: Hardy
authors.forename: Manuel
authors.initials: M
authors.lastname: Deprez
authors.forename: Jean
authors.initials: J
authors.lastname: Delwaide
authors.forename: Jacques
authors.initials: J
authors.lastname: Belaïche
authors.forename: Jacques
authors.initials: J
authors.lastname: Boniver
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary*; D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000556:secondary*; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D009378:Neoplasms, Multiple Primary; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology*; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D010751:Phosphopyruvate Hydratase