Calcium transport proteins in active secretory zones: Na-Ca exchange isoforms and exchanger kinetic properties in chromaffin granules and plasma membranes.
We have found that Na-Ca exchange influences Ca(2+) efflux, signal decay, and the rate of secretion in chromaffin cells. We now report the presence of two distinct splicing variant isoforms of Na-Ca exchange proteins in bovine chromaffin cells and their transport properties in chromaffin granules and plasma membrane vesicles.
Schneider
A S
AS
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA. schneia@mail.amc.edu
Mah
S J
SJ
Farhadi
M
M
Grindi
E
E
Davis
K H
KH
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D019439:Chromaffin Cells / Q000378:metabolism*; D005091:Exons; D007700:Kinetics; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D020033:Protein Isoforms; D017386:Sequence Homology, Amino Acid; D019831:Sodium-Calcium Exchanger / Q000737:chemistry*
D020033:Protein Isoforms; D019831:Sodium-Calcium Exchanger; D002118:Calcium