Overtreatment in children with epilepsy.
Children with epilepsy are at risk for overtreatment, defined as the use of an excessive number or amount of antiepiletic drugs (AEDs). While the extent of overtreatment of epilepsy in children is not known, there is increasing awareness that overtreatment with AEDs contributes to the morbidity associated with childhood epilepsy. Reasons for overtreatment include using AEDs in a child with seizures who does not require therapy, choosing an inappropriate AED for the seizure type or syndrome; treating non-epileptic behaviors as seizures, use of polytherapy when monotherapy would suffice, and inadequate therapeutic options. Despite the introduction of eight new AEDs in the United States during the last decade, many children continue to be treated with the older generation sedative AEDs. Numerous investigators have now demonstrated that sedative AEDs can be safely removed from the drug regimen of children with epilepsy with resultant improvement in behavior, alertness, and improved seizure control. However, the biggest obstacle to overtreatment is the lack of effective therapies for many of the childhood epileptic syndromes. Until there are more effective therapies developed it is highly likely that children will continue to be over-medicated on ineffective and detrimental AEDs.
Holmes
Gregory L
GL
Department of Neurology, Harvard Medical School, Children's Hospital Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA. gregory.holmesg@tch.harvard.edu
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000139:chemically induced; D004347:Drug Interactions; D062787:Drug Overdose; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D005544:Forecasting; D006801:Humans; D009017:Morbidity / Q000639:trends; D012306:Risk
D000927:Anticonvulsants