Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation.
Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane-microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton-mediated architecture of the immunological synapse that plays a role in T-cell receptor clustering, protein kinase C theta translocation and intracellular signaling.
Das
Vincent
V
Unité de Biologie des Interactions Cellulaires, CNRS URA 1960, Paris, France.
Nal
Béatrice
B
Roumier
Anne
A
Meas-Yedid
Vannary
V
Zimmer
Christophe
C
Olivo-Marin
Jean-Christophe
JC
Roux
Pascal
P
Ferrier
Pierre
P
Dautry-Varsat
Alice
A
Alcover
Andrés
A
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000276:immunology; D000199:Actins / Q000276:immunology; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D017252:CD3 Complex / Q000378:metabolism; D016764:Cell Polarity; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000276:immunology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007365:Intercellular Junctions / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D010750:Phosphoproteins / Q000737:chemistry / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D000099149:Ezrin; D054378:Acetogenins
D015107:4-Butyrolactone; D000199:Actins; D017252:CD3 Complex; D003598:Cytoskeletal Proteins; D010750:Phosphoproteins; D011948:Receptors, Antigen, T-Cell; D000099149:Ezrin; C438920:coronin acetogenin; D054378:Acetogenins