Cytotoxic amides from Piper sintenense.
A new alkaloid, pipersintenamide ( 1), together with fourteen known compounds, have been isolated from the whole plant of Piper sintenense. The structures of these compounds were elucidated by spectroscopic analysis. Pipersintenamide, sintenpyridone, sarmentine, and 1-(3,4-methylenedioxyphenyl)-1 E-dodecene at 20 microg/ml exhibited effective cytotoxicities (cell survival < 15 %) against CCRF-CEM, HL-60, PC-3, and HA22T cell lines.
Chen
Jih-Jung
JJ
Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China. m635013@cc.kmu.edu.tw
Huang
Yu-Chun
YC
Chen
Yu-Chang
YC
Huang
Yao-Ting
YT
Wang
Shih-Wei
SW
Peng
Chieh-Yu
CY
Teng
Che-Ming
CM
Chen
Ih-Sheng
IS
D000475:Alkenes / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D008517:Phytotherapy; D031701:Piper; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000475:Alkenes; D000972:Antineoplastic Agents, Phytogenic; D010880:Piperidines; D010936:Plant Extracts; C470474:pipersintenamide