Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians.
Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.
Ifergan
Igal
I
Laboratoire d'Immunogénétique, Centre de Recherche du Centre Hospitalier, l'Université de Montréal, Montréal, Canada.
Bernard
Nicole F
NF
Bruneau
Julie
J
Alary
Michel
M
Tsoukas
Christos M
CM
Roger
Michel
M
D005787:Gene Frequency; D019450:Genes, MDR; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D011110:Polymorphism, Genetic; D011446:Prospective Studies