Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens.
Over the last 10 years, numerous cases of intoxications, leading for the most part to end-stage renal failure, have been reported after consumption of slimming regimens made of Chinese herbal preparations. These intoxications were associated with species of the Aristolochia genus, such as Aristolochia fangchi (Aristolochiaceae), known to contain very nephrotoxic and carcinogenic metabolites named aristolochic acids. Several commercial dietary supplements, teas and phytomedicines used as slimming regimens were analysed for their aristolochic acid I content. A preliminary detection of this toxic compound was made by thin-layer chromatography. The presence of aristolochic acid I in these preparations was confirmed by a HPLC/UV-DAD/MS analysis. A quantitative determination of aristolochic acid I was also achieved in the incriminated preparations using both UV and MS detection. Out of 42 analysed preparations, four were found to contain aristolochic acid I and two were suspected to contain aristolochic acid derivatives. Immediate removal of these products from the Swiss market was called for.
Ioset
J-R
JR
Institut de Pharmacognosie et Phytochimie, BEP, Université de Lausanne, Switzerland.
Raoelison
G E
GE
Hostettmann
K
K
D019440:Anti-Obesity Agents / Q000009:adverse effects* / Q000737:chemistry / Q000302:isolation & purification; D030022:Aristolochia / Q000737:chemistry*; D034341:Aristolochic Acids / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification*; D002273:Carcinogens / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D019587:Dietary Supplements / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans
D019440:Anti-Obesity Agents; D034341:Aristolochic Acids; D002273:Carcinogens; D004365:Drugs, Chinese Herbal; C000228:aristolochic acid I