An uncommon tumor in a renal graft recipient: a diagnostic and therapeutic challenge.
The development of malignancies after solid organ transplantation represents an increasing clinical problem complicating the long-term follow-up of transplant recipients. In this case report the authors describe the rare triple combination of a simultaneous hepatocellular carcinoma with a glucagonoma and a splenic hamartoma in a renal allograft recipient. It is not only the first published report of a glucagonoma occurring after renal transplantation but serves also as an illustration of the therapeutic decision making in the setting of the immune-compromised host. This case report also illustrates the different imaging modalities that can be used for the diagnosis of neuroendocrine tumors.
Claes
Kathleen
K
Department of Nephrology and Transplantation, University Hospital Gasthuisberg, Leuven, Belgium. Kathleen.Claes@uz.kuleuven.ac.be
Kuypers
Dirk
D
Evenepoel
Pieter
P
Maes
Bart
B
Roskams
Tania
T
Aerts
Raymond
R
Pirenne
Jacques
J
Mathieu
Chantal
C
Vanrenterghem
Yves
Y
D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005935:Glucagonoma / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D006222:Hamartoma / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery