Multidrug resistance in ovarian cancer: comparing an immunocytochemical study and ATP-tumor chemosensitivity assay.
The aim of our study was to evaluate the possible prognostic and predictive significance of the expression of P-glycoprotein, a transmembrane transport protein related to multidrug resistance, in previously untreated patients with FIGO stage III ovarian cancer; to compare the results of immunocytochemical analysis of tissue sections of tumors to the in vitro chemosensitivity to cytotoxic drug of fresh samples of the same tumors; and to evaluate survival in women who underwent the same surgical treatment and the same adjuvant chemotherapy.
Raspollini
M R
MR
Department of Human Pathology and Oncology, University of Florence, Florence, Italy.
Pinzani
P
P
Pazzagli
M
M
Baroni
G
G
Taddei
A
A
Amunni
G
G
Villanucci
A
A
Taddei
G L
GL
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis / Q000096:biosynthesis*; D000255:Adenosine Triphosphate / Q000032:analysis / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D002277:Carcinoma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D019450:Genes, MDR; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D013534:Survival
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D015415:Biomarkers; D015251:Epirubicin; D000255:Adenosine Triphosphate; D003520:Cyclophosphamide; D002945:Cisplatin