Carnosine modifies the incidence of genetically abnormal sex cells in the testes of senescence-accelerated mice.
The quantitative micronucleus test showed that the natural dipeptide carnosine increases the count of aberrant spermatogonia and round spermatids in the testes in SAMR1 mice resistant to accelerated aging by 64 and 85%, respectively, compared to the control. However, this agent did not modify the incidence of chromosome mutations in spermatogenic cells in SAMP1 mice predisposed to accelerated aging.
Zakhidov
S T
ST
Department of Embryology, Biological Faculty, Institute of Mechanics, M. V. Lomonosov Moscow State University. STZ-su@mail.ru
Gopko
A V
AV
Semenova
M L
ML
Mikhaleva
Ya Yu
YY
Makarov
A A
AA
Kulibin
A Yu
AY
D000375:Aging; D000818:Animals; D002336:Carnosine / Q000378:metabolism / Q000494:pharmacology*; D016922:Cellular Senescence; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D013087:Spermatids / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
D002336:Carnosine