title: Detergent-induced epidermal barrier dysfunction and its prevention.
abstract: Various detergents are used as skin cleansing products. In some cases, skin cleanser removes not only dirt but also valuable skin lipids. Therefore, detergents may disrupt epidermal barrier function despite that using of detergents are required for good skin hygiene. Lipid supplements can reverse detergent-induced dysfunction of the skin barrier. Elevated transepidermal water loss (TEWL) and riboflavin penetration in 5% SLS-treated rat and human skin were reversed by supplementation of monoglyceride (MG), squalene (SQ), cholesterol ester (CE) and pseudo-ceramide (Cer2). MG and Cer2 achieved the best results. MG appears to inhibit elution of intercellular ceramides, since more ceramides remained when the detergent was supplemented with MG. Topical application of Cer2 is not effective for recovery from artificially induced barrier disruption, but supplemented Cer2 into skin cleanser has a beneficial effect for prevention of detergent-induced barrier disruption. In conclusion, the prevention of barrier disruption is most important matter for maintaining skin health and barrier function. Therefore, we think that Cer2-supplemented skin cleanser is useful for conservation of skin barrier function.
authors.affiliation: Department of Dermatology, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan. okuda.minehiro@kao.co.jp
authors.forename: Minehiro
authors.initials: M
authors.lastname: Okuda
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiike
authors.forename: Hideoki
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002518:Ceramides / Q000008:administration & dosage / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology*; D004338:Drug Combinations; D004817:Epidermis / Q000187:drug effects* / Q000378:metabolism*; D005989:Glycerides / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012256:Riboflavin / Q000493:pharmacokinetics; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D002518:Ceramides; D003902:Detergents; D004338:Drug Combinations; D005989:Glycerides; D008055:Lipids; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D012256:Riboflavin