Combined vitamin C and E supplementation retards early progression of arteriosclerosis in heart transplant patients.
The development of arteriosclerosis is the limiting factor for the long-term survival and the major cause of mortality in patients with heart transplants. Various factors, including oxidative stress, contribute to the progression of the disease. In a recent clinical trial using the intravascular ultrasound technique, which detects the early stages of disease development, supplementation with vitamins C and E retarded the progression of coronary arteriosclerosis during the early stage following cardiac transplantation.
Liu
Liping
L
Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.
Meydani
Mohsen
M
D001161:Arteriosclerosis / Q000503:physiopathology / Q000517:prevention & control*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D019587:Dietary Supplements; D004730:Endothelium, Vascular / Q000503:physiopathology; D016027:Heart Transplantation; D006801:Humans; D018384:Oxidative Stress; D014810:Vitamin E / Q000008:administration & dosage*
D014810:Vitamin E; D001205:Ascorbic Acid