title: [Intravenous cyclosporine A in the treatment of refractory Crohn's disease].
abstract: BACKGROUND
  Intravenous cyclosporine (iv CyA) is efficient in ulcerative colitis, but data are scarce in Crohn's disease (CD).
  
  
  METHODS
  Patients with CD refractory to standard therapy who were treated with iv CyA.
  
  
  RESULTS
  All patients with steroid-refractory disease achieved a complete response. In perianal disease, a complete response was attained in 3 out of 16 patients, while 9 showed a partial response. Only 1 out of 8 patients with enteric fistulae showed a complete response and a further one had a partial response.
  
  
  CONCLUSIONS
  Intravenous CyA seems to be useful in steroid-refractory CD but not in fistulizing CD.
authors.affiliation: Servicio de Aparato Digestivo. Hospital Universitari Germans Trias i Pujol. Badalona. Barcelona. España.
authors.forename: Esther
authors.initials: E
authors.lastname: García-Planella
authors.forename: Eugeni
authors.initials: E
authors.lastname: Domènech
authors.forename: Eduard
authors.initials: E
authors.lastname: Cabré
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Bernal
authors.forename: Miquel Angel
authors.initials: MA
authors.lastname: Gassull
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine