title: Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities.
abstract: Bioguided-fractionation of an acetone extract of the roots of Salvia cilicica (Lamiaceae) led to isolation of two new diterpenes, 7-hydroxy-12-methoxy-20-nor-abieta-1,5(10),7,9,12-pentaen-6,14-dione and abieta-8,12-dien-11,14-dione (12-deoxy-royleanone), together with oleanolic acid, ursolic acid, ferruginol, inuroyoleanol and cryptanol. Their structures were determined spectroscopically, which included HREIMS and 2D NMR spectroscopic analysis. The new abietane derivatives showed appreciable in vitro antileishmanial activity against intracellular amastigote forms of both Leishmania donovani (IC(50) values of 170 and 120 nM, respectively) and Leishmania major (IC(50) values of 290 and 180 nM, respectively). The triterpenoic acids were found to be potently active against amastigote (IC(50) values of 7-120 nM) and moderately active against promastigote stages (IC(50) values of 51-137 nM) of the two Leishmania species.
authors.affiliation: Freie Universität Berlin, Institut für Pharmazie, Pharmazeutische Biologie, Königin-Luise-Str 2+4, D-14195 Berlin, Germany.
authors.forename: Nur
authors.initials: N
authors.lastname: Tan
authors.forename: Macki
authors.initials: M
authors.lastname: Kaloga
authors.forename: Oliver A
authors.initials: OA
authors.lastname: Radtke
authors.forename: Albrecht F
authors.initials: AF
authors.lastname: Kiderlen
authors.forename: Sevil
authors.initials: S
authors.lastname: Oksüz
authors.forename: Ayhan
authors.initials: A
authors.lastname: Ulubelen
authors.forename: Herbert
authors.initials: H
authors.lastname: Kolodziej
mesh_terms: D045784:Abietanes; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007893:Leishmania donovani / Q000187:drug effects*; D018320:Leishmania major / Q000187:drug effects*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C473685:7-hydroxy-12-methoxy-20-nor-abieta-1,5(10),7,9,12-pentaen-6,14-dione; D045784:Abietanes; D000981:Antiprotozoal Agents; D004224:Diterpenes; D014315:Triterpenes; C473686:abieta-8,12-dien-11,14-dione (12-deoxy-royleanone)