title: Audit of intraoperative and early postoperative complications after introduction of mesorectal excision for rectal cancer.
abstract: OBJECTIVE
  To compare complication rates after rectal resection using a conventional surgical technique (1983-1992) and mesorectal excision (1993-2000), and to find out whether the rate of complications changed with time after the introduction of mesorectal excision.
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  University hospital, Norway.
  
  
  METHODS
  All patients who had rectal resections for cancer in the period 1983-2000.
  
  
  METHODS
  In the conventional surgery period 217, and in the mesorectal excision period 176, patients had rectal resections. The mesorectal excision period was split in two, the early and the late mesorectal excision period, 88 rectal resections being performed in each period. Total mesorectal excision was done in 118 patients, and partial mesorectal excision in 58.
  
  
  METHODS
  Major surgical complications in both periods; intraoperative bleeding, transfusions during the hospital stay, and cardiovascular complications in the mesorectal excision period.
  
  
  RESULTS
  23/217 (11%) developed major surgical complications in the conventional surgery period, compared with 17/88 (19%) in the early mesorectal excision period (p = 0.04). This was caused by an increased incidence of anastomotic leaks after low anterior resection, being 11/122 (9%) in the conventional surgery period and 12/52 (23%) in the early mesorectal excision period (p = 0.01). The incidence of anastomotic leaks declined to 5/61 (8%) in the late mesorectal excision period (p = 0.03). Multiple regression analysis identified a low anastomosis, major bleeding, and age over 75 years as significant risk factors for the development of anastomotic leaks. Major intraoperative bleeding occurred in 36/84 (43%) of the patients in the early and 22/82 (27%) in the late mesorectal period (p = 0.04). Blood transfusions were given to 61/84 (74%) in the early mesorectal period and 41/82 (50%) in the late period (p < 0.01).
  
  
  CONCLUSIONS
  The incidence of surgical complications increased significantly after the introduction of mesorectal excision, but declined with time.
authors.affiliation: Department of Surgery, Aker Hospital, Oslo, Norway.
authors.forename: Arild
authors.initials: A
authors.lastname: Nesbakken
authors.forename: Knut
authors.initials: K
authors.lastname: Nygaard
authors.forename: Ola
authors.initials: O
authors.lastname: Westerheim
authors.forename: Ole Christian
authors.initials: OC
authors.lastname: Lunde
authors.forename: Tom
authors.initials: T
authors.lastname: Mala
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects*; D016063:Blood Loss, Surgical; D003082:Colectomy / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006331:Heart Diseases / Q000209:etiology / Q000401:mortality; D006470:Hemorrhage / Q000209:etiology / Q000401:mortality; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology; D007431:Intraoperative Complications / Q000453:epidemiology; D008171:Lung Diseases / Q000209:etiology / Q000401:mortality; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D019370:Observation; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000601:surgery*; D012189:Retrospective Studies