title: Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.
abstract: A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion. This reaction was considered to fit with coronary vasospasm. Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.
authors.affiliation: Mary Potter Oncology Centre, Little Company of Mary Hospital, Groenkloof, Pretoria, Republic of South Africa. mrc@mpoc.co.za
authors.forename: Martin R
authors.initials: MR
authors.lastname: Chasen
authors.forename: Iftikar O
authors.initials: IO
authors.lastname: Ebrahim
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001024:Aortic Valve Stenosis / Q000150:complications; D002114:Calcinosis / Q000150:complications; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000175:diagnosis; D003520:Cyclophosphamide / Q000008:administration & dosage; D004342:Drug Hypersensitivity / Q000209:etiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D010051:Ovarian Neoplasms / Q000188:drug therapy; D016066:Pleural Effusion, Malignant / Q000150:complications
chemical_list: D003520:Cyclophosphamide; D016190:Carboplatin