title: Platelet glycoprotein IIb/IIIa inhibition using eptifibatide with primary coronary stenting for acute myocardial infarction: a 30-day follow-up study.
abstract: The results of primary coronary stenting for acute myocardial infarction (AMI) have been reported to improve significantly with the concomitant administration of platelet glycoprotein IIb/IIIa inhibitor abciximab. There are, however, no data available with the use of eptifibatide, a more cost-effective, small-molecule GP IIb/IIIa blocker with a shorter half-life. In a prospective multicenter feasibility and efficacy study, we assigned 55 consecutive patients with AMI being taken up for primary stenting to receive eptifibatide just before the procedure (two boluses of 180 microg/kg 10 min apart and a 24-hr infusion of 2 microg/kg/min). Clinical outcomes were evaluated at 30 days after the procedure. The angiographic patency of the vessel with TIMI flow rates, TIMI myocardial perfusion (TMP) grade, and corrected TIMI frame counts were assessed at the end of procedure and before hospital discharge. At 30 days, the primary endpoint, a composite of death, myocardial infarction, and urgent target vessel revascularization (TVR) was seen in 12.7% of patients. The TIMI 3 and TMP grade 3 flow, which was seen in 93% and 86% of patient, respectively, at the end of the procedure, declined to 86% and 78%, respectively (P < 0.05) before hospital discharge. Corrected TIMI frame counts also decreased from 25.7 +/- 7.2 to 22.9 +/- 6.8 (P < 0.05). There were five (9.1%) instances of subacute thrombosis (SAT) presenting as AMI, needing urgent TVR in all, within 3-5 days of the primary procedure. No excessive bleeding complication, directly attributable to the use of eptifibatide, was observed. The study was terminated prematurely because of an unacceptable SAT rate. Administration of eptifibatide along with primary stenting for AMI is associated with a high TIMI 3 and TMP grade 3 flow acutely. However, these flows decline significantly before hospital discharge and lead to a high rate of SAT. The dosage and duration of infusion of eptifibatide in this setting needs further evaluation.
authors.affiliation: Department of Interventional Cardiology, Batra Hospital and Medical Research Centre, New Delhi, India. ukaul@del3.vsnl.net.in
authors.forename: Upendra
authors.initials: U
authors.lastname: Kaul
authors.forename: Ripen K
authors.initials: RK
authors.lastname: Gupta
authors.forename: Kottaram K
authors.initials: KK
authors.lastname: Haridas
authors.forename: Saligrama S
authors.initials: SS
authors.lastname: Ramesh
authors.forename: Kamal K
authors.initials: KK
authors.lastname: Sethi
authors.forename: Balbir
authors.initials: B
authors.lastname: Singh
authors.forename: Rajiv
authors.initials: R
authors.lastname: Agarwal
authors.forename: Ram D
authors.initials: RD
authors.lastname: Yadave
authors.forename: Tapan
authors.initials: T
authors.lastname: Ghose
authors.forename: Rakesh R
authors.initials: RR
authors.lastname: Sapra
authors.forename: Rajiv
authors.initials: R
authors.lastname: Bajaj
authors.forename: Madhukar
authors.initials: M
authors.lastname: Shahi
authors.forename: Ajit
authors.initials: A
authors.lastname: Bhagwat
authors.forename: Pramod
authors.initials: P
authors.lastname: Kumar
authors.forename: Omen P
authors.initials: OP
authors.lastname: Mathews
authors.forename: Pratik K
authors.initials: PK
authors.lastname: Soni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019917:Blood Vessel Prosthesis Implantation; D017023:Coronary Angiography; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D000077542:Eptifibatide; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors* / Q000187:drug effects*; D011446:Prospective Studies; D015607:Stents; D013997:Time Factors; D014654:Vascular Patency / Q000187:drug effects
chemical_list: D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000077542:Eptifibatide