title: Clear cell sarcoma of the stomach.
abstract: OBJECTIVE
  Clear cell sarcoma is a high-grade sarcoma with morphological features resembling malignant melanoma. This tumour is reported to display a characteristic distribution pattern nearly always involving the extremities. We report the first case of clear cell sarcoma of the stomach.
  
  
  RESULTS
  A 30-year-old male developed a huge tumour of the stomach, which at first glance could be considered as a poorly differentiated carcinoma. Immunohistochemical and ultrastructural examinations were consistent with a diagnosis of metastatic melanoma. However, cytogenetic examination revealed a t(12;22) translocation, specific for clear cell sarcoma. This was confirmed by fluorescence in-situ hybridization.
  
  
  CONCLUSIONS
  Making a reliable diagnosis of clear cell sarcoma of the stomach requires cytogenetic or molecular diagnostic investigations, particularly to rule out metastatic melanoma. This diagnosis avoids an unnecessary search for a primary melanoma.
authors.affiliation: Stichting PAMM, Catharina Hospital, Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands. P.Pauwels@pamm.nl
authors.forename: P
authors.initials: P
authors.lastname: Pauwels
authors.forename: M
authors.initials: M
authors.lastname: Debiec-Rychter
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: T
authors.initials: T
authors.lastname: Vlasveld
authors.forename: B
authors.initials: B
authors.lastname: den Butter
authors.forename: A
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: P C W
authors.initials: PC
authors.lastname: Hogendoorn
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000473:pathology; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008545:Melanoma / Q000473:pathology; D008854:Microscopy, Electron; D034802:RNA-Binding Protein EWS / Q000235:genetics; D018227:Sarcoma, Clear Cell / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure; D014178:Translocation, Genetic
chemical_list: D034802:RNA-Binding Protein EWS