title: Production and dosimetry of [14O]water for PET activation studies.
abstract: [14O]water was produced by the 14N(p,n)14O reaction in quantities greater than 80mCi (EOB). The carbon-11 impurity in the final product was approximately 0.003 +/- 0.002% of 14O activity at EOB. A factor of 0.5 +/- 0.02 was obtained to correct the dose calibrator for the additional 2.313 MeV gamma-ray. The effective dose equivalent was calculated for 14O and 15O using MIRDOSE, and the 14O dose was found to be approximately 70% of that for 15O. For scanner performance based on noise equivalent count measurements, the peak activity concentration for 14O was 30% lower than that for 15O. At their peak activity concentrations the noise equivalent count rate for 14O was found to be about 13% less than that for 15O.
authors.affiliation: PET Imaging Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. msajjad@buffalo.edu
authors.forename: Munawwar
authors.initials: M
authors.lastname: Sajjad
authors.forename: Mehran R
authors.initials: MR
authors.lastname: Zaini
authors.forename: Jeih-San
authors.initials: JS
authors.lastname: Liow
authors.forename: David A
authors.initials: DA
authors.lastname: Rottenberg
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Strother
mesh_terms: D001775:Blood Circulation; D002560:Cerebrovascular Circulation; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D009928:Organ Specificity; D010104:Oxygen Radioisotopes / Q000008:administration & dosage / Q000302:isolation & purification*; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D011874:Radiometry; D014055:Tomography, Emission-Computed; D014867:Water / Q000737:chemistry*
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water