title: Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis.
abstract: Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.
authors.affiliation: School of Life and Environmental Sciences, University of Nottingham, University Park, United Kingdom.
authors.forename: Carolann
authors.initials: C
authors.lastname: McGuire
authors.forename: Weng C
authors.initials: WC
authors.lastname: Chan
authors.forename: Derek
authors.initials: D
authors.lastname: Wakelin
mesh_terms: D000281:Administration, Intranasal; D000595:Amino Acid Sequence; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D002772:Cholera Toxin / Q000235:genetics / Q000276:immunology; D005260:Female; D007114:Immunization; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology; D017160:Trichinella spiralis / Q000276:immunology*; D014235:Trichinellosis / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D010455:Peptides; D014614:Vaccines, Synthetic; D002772:Cholera Toxin