title: New disc-based technologies for diagnostic and research applications.
abstract: The role of genotypic analysis in disease diagnostics and drug response assessment is continually expanding. New genomic discoveries combined with new, novel technologies may provide a greater range of testing capabilities in the near future. We describe the application of nanotechnology, in which DNA microarrays have been placed in a microchannel environment that can be read and analyzed in an optical (CD/DVD) disc drive system. The potential exists to combine molecular and immunological applications together into a rapid, low-cost, high-capacity screening platform. The relevance of this technology is discussed in respect to infectious agent detection, pharmacogenomics, neurogenomics and genetic variations associated with neurologic diseases.
authors.affiliation: Burstein Technologies Inc., Irvine, California 92618, USA. rajbarathur@bursteinlabs.com
authors.forename: Raj
authors.initials: R
authors.lastname: Barathur
authors.forename: Jack
authors.initials: J
authors.lastname: Bookout
authors.forename: Srinand
authors.initials: S
authors.lastname: Sreevatsan
authors.forename: John
authors.initials: J
authors.lastname: Gordon
authors.forename: Martina
authors.initials: M
authors.lastname: Werner
authors.forename: Gautam
authors.initials: G
authors.lastname: Thor
authors.forename: Mark
authors.initials: M
authors.lastname: Worthington
mesh_terms: D005821:Genetic Techniques; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007158:Immunologic Techniques; D008967:Molecular Biology / Q000379:methods; D009422:Nervous System Diseases / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods