[Effect of soybean isoflavones on antioxidant status in rats fed diet with oxidized linseed oil].
The maintenance of male Wistar rats on semi-synthetic diets containing oxidized flaxseed oil for 4 weeks caused decrease in serum total antioxidant activity, significant suppression of microsomal UDP-glucuronosyl transferase activity and benzpyrene hydroxylase activity, increase in reduced glutathione level and catalase activity of liver. Supplementation of diets with 0.05% of soy isoflavones has resulted in normalization of investigated characteristics.
Kravchenko
L V
LV
Morozov
S V
SV
Deriagina
V P
VP
Avren'eva
L I
LI
Guseva
G V
GV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001579:Benzopyrene Hydroxylase / Q000187:drug effects / Q000378:metabolism; D002374:Catalase / Q000097:blood / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology; D019587:Dietary Supplements; D014453:Glucuronosyltransferase / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects; D005980:Glutathione Reductase / Q000187:drug effects / Q000378:metabolism; D005982:Glutathione Transferase / Q000097:blood / Q000187:drug effects; D007529:Isoflavones / Q000494:pharmacology*; D008043:Linseed Oil / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max / Q000737:chemistry*
D000975:Antioxidants; D004041:Dietary Fats; D007529:Isoflavones; D008043:Linseed Oil; D002374:Catalase; D005979:Glutathione Peroxidase; D001579:Benzopyrene Hydroxylase; D005980:Glutathione Reductase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D005978:Glutathione