title: A generic computerized method for estimate of familial risks.
abstract: Most guidelines developed for cancers screening and for cardiovascular risk management use rules to estimate familial risk. These rules are complex, difficult to memorize, and need to collect a complete pedigree. This paper describes a generic computerized method to estimate familial risks and its implementation in an internet-based application. The program is based on 3 generic models: a model of the family; a model of familial risk; a display model for the pedigree. The model of family allows to represent each member of the family and to construct and display a family tree. The model of familial risk is generic and allows easy update of the program with new diseases or new rules. It was possible to implement guidelines dealing with breast and colorectal cancer and cardiovascular diseases prevention. First evaluation with general practitioners showed that the program was usable. Impact on quality of familial risk estimate should be more documented.
authors.affiliation: Public Health and Medical Informatics, Broussais Hotel Dieu University, Paris 75006, France. isabelle.colombet@spim.jussieu.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Colombet
authors.forename: Yigang
authors.initials: Y
authors.lastname: Xu
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Jaulent
authors.forename: Daniel
authors.initials: D
authors.lastname: Desages
authors.forename: Patrice
authors.initials: P
authors.lastname: Degoulet
authors.forename: Gilles
authors.initials: G
authors.lastname: Chatellier
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors