title: [The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury].
abstract: OBJECTIVE
  To investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury.
  
  
  METHODS
  Rats inflicted with smoke inhalation injury were employed as the model. WBC in BALF (bronchoalveolar lavage fluid), MPO (myeloperoxidase) activity, hydrogen peroxide (H(2)O(2)) content, GSH (glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined.
  
  
  RESULTS
  Postinjury WBC in BALF, MPO activity in pulmonary tissue and H(2)O(2) content decreased obviously after NAC treatment. But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC.
  
  
  CONCLUSIONS
  NAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury. AS a result, the pulmonary antioxidant capacity was improved.
authors.affiliation: Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Zuhong
authors.initials: Z
authors.lastname: Fu
authors.forename: Zongcheng
authors.initials: Z
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Liu
authors.forename: Baobin
authors.initials: B
authors.lastname: He
authors.forename: Zhixia
authors.initials: Z
authors.lastname: Liu
authors.forename: Jiangping
authors.initials: J
authors.lastname: Wu
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015208:Smoke Inhalation Injury / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
chemical_list: D016166:Free Radical Scavengers; D006861:Hydrogen Peroxide; D009195:Peroxidase; D005978:Glutathione; D000111:Acetylcysteine