title: Clinicopathologic correlations of genomic gains and losses in follicular lymphoma.
abstract: OBJECTIVE
  To evaluate the clinical relevance of genomic aberrations in follicular lymphomas (FLs).
  
  
  METHODS
  In this study, we analyzed 124 biopsy samples of patients with FL using comparative genomic hybridization.
  
  
  RESULTS
  In 87 cases (70%), genomic imbalances were detectable. The most frequent aberrations were gains of chromosome arms 7p (21 patients), 7q (21 patients), Xp (16 patients), 12q (15 patients), and 18q (14 patients) as well as losses on 6q (21 patients). Grades 2 and 3 according to the World Health Organization classification correlated with a more complex karyotype (P <.0001). In a subset of 82 patients, a comprehensive clinical data set was available. In a multivariate analysis including all clinical risk factors of the International Prognostic Index as well as genomic aberrations, the loss of material on chromosomal bands 6q25q27 was the strongest predictor of a shorter survival (P =.0001; hazard ratio, 6.5), followed by elevated serum lactate dehydrogenase level (P =.0009; hazard ratio, 4.9), the presence of more than one extranodal manifestation (P =.017; hazard ratio, 4.2), and age greater than 60 years (P =.022; hazard ratio, 2.6).
  
  
  CONCLUSIONS
  These data indicate that genomic aberrations may contribute significantly to risk assessment in patients with FL, the majority of whom are included in low-risk groups using established clinical prognostic scores.
authors.affiliation: Abteilung Innere Medizin III, Pathologie, and Biometrie und Medizinische Dokumentation, Universität Ulm, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Viardot
authors.forename: Peter
authors.initials: P
authors.lastname: Möller
authors.forename: Josef
authors.initials: J
authors.lastname: Högel
authors.forename: Kirsten
authors.initials: K
authors.lastname: Werner
authors.forename: Gunhild
authors.initials: G
authors.lastname: Mechtersheimer
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Ho
authors.forename: German
authors.initials: G
authors.lastname: Ott
authors.forename: Thomas F E
authors.initials: TF
authors.lastname: Barth
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.forename: Stefan
authors.initials: S
authors.lastname: Gesk
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlegelberger
authors.forename: Hartmut
authors.initials: H
authors.lastname: Döhner
authors.forename: Martin
authors.initials: M
authors.lastname: Bentz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002887:Chromosomes, Human, Pair 18; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005629:Frozen Sections; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D014178:Translocation, Genetic; D014960:X Chromosome
chemical_list: D004273:DNA, Neoplasm; D007770:L-Lactate Dehydrogenase