title: Prenatal course and pregnancy outcome of fetuses with a transient nuchal translucency.
abstract: OBJECTIVE
  This study was designed to correlate fetuses in a normal prenatal population who exhibited transient nuchal translucency (NT) with both prenatal course and pregnancy outcome.
  
  
  METHODS
  The fetuses with abnormal NT were followed by ultrasonography at 1-2-week intervals during their prenatal course. Fetuses with NT who exhibited no detectable congenital malformations were defined as the NTO group; fetuses with abnormal NT and structural malformations but no chromosomal abnormalities were placed in the SM group; and fetuses with abnormal NT, structural malformations, and chromosomal abnormalities were categorized as the CA group. The groups were compared by: maternal age, weeks of gestation by ultrasound and the NT value at the initial exam, the maximum NT value, and the duration of abnormal NT.
  
  
  RESULTS
  During the study period, 92 fetuses with abnormal NT were found, monochorionic twins excluded. Of the 92 fetuses, 80 were in the NTO group, 10 were in the SM group, and two were in the CA group. The maternal age and the gestational weeks at the initial diagnosis were not significantly different in the NTO and the SM groups. However, the NT value at the initial diagnosis, maximum NT value, and the duration of abnormal NT were significantly greater in the SM group than those values in the NTO group.
  
  
  CONCLUSIONS
  Fetuses with transient nuchal translucency commonly had structural malformations, particularly fetuses with significant and large persistent NT.
authors.affiliation: Department of Obstetrics and Gynecology, Yamanashi Medical University, Yamanashi, Japan. yfukada@res.yamanashi-med.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Fukada
authors.forename: A
authors.initials: A
authors.lastname: Amemiya
authors.forename: K
authors.initials: K
authors.lastname: Kohno
authors.forename: R
authors.initials: R
authors.lastname: Sunami
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Hoshi
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000196:embryology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D009333:Neck / Q000000981:diagnostic imaging / Q000196:embryology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D016216:Ultrasonography, Prenatal