title: Estimation of plasma insulin from plasma glucose.
abstract: Two plasma insulin estimators are derived and evaluated in this paper. The estimators use continuously monitored plasma glucose, and they are based on a simple mathematical model of glucose-insulin metabolism. The first estimator (Estimator 1) was obtained from the glucose subsystem of the simplified model, which includes plasma glucose and interstitial insulin compartments. The second estimator (Estimator 2) was developed from the insulin kinetics subsystem of the simplified model. The performances of the estimators were compared using computer simulations and data from clinical intravenous glucose tolerance test procedures and from animal experiments.
authors.affiliation: Department of Electrical Engineering, Mahidol University, 25/25 Bhuddah-Monthon 4, Nakhon-Prathom 73170, Thailand. egcnp@mucc.mahidol.ac.th
authors.forename: Chatchai
authors.initials: C
authors.lastname: Neatpisarnvanit
authors.forename: John Robert
authors.initials: JR
authors.lastname: Boston
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D015190:Blood Glucose Self-Monitoring / Q000379:methods; D003198:Computer Simulation; D004285:Dogs; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D008954:Models, Biological; D008955:Models, Cardiovascular; D008956:Models, Chemical; D017711:Nonlinear Dynamics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013269:Stochastic Processes
chemical_list: D001786:Blood Glucose; D007328:Insulin