Experimental off-pump coronary bypass using a robotic telemanipulation system.
We hypothesized that a high-quality anastomosis between the left internal thoracic artery and the left anterior descending coronary artery could be constructed off-pump using a 4-degrees-of-freedom robotic telemanipulation system, endoscopic myocardial stabilization, and two-dimensional visualization. Nine swine were used. Three ports were created on the left chest for the endoscope and the two robotic arms, and another port was created on the right chest for the endostabilizer. Quality of anastomosis was assessed by angiography, analysis of flow, survival after proximal coronary ligation, and histopathology. All nine anastomoses were completed successfully in 22 +/- 3.6 minutes without the need for repair stitches. Left internal thoracic artery flow was 21.6 +/- 2.5 ml/min with diastolic dominant pattern. Eight animals (89%) survived for 60 minutes with the proximal left anterior descending coronary ligated. Angiographic patency was 100% with Fitzgibbon grade A in all. Histopathology of the anastomosis demonstrated minor changes in the integrity of the endothelium and the internal elastic lamina and absence of medial necrosis. We have demonstrated in our robotic off-pump coronary bypass model that a high-quality anastomosis can be constructed between the left internal thoracic artery and the left anterior descending coronary artery. These results support continued research towards robotic endoscopic off-pump CABG.
Zenati
Marco A
MA
Division of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213-2582, USA. zenatim@msx.upmc.edu
Nichols
Larry
L
Bonanomi
Gianluca
G
Griffith
Bartley P
BP
D000714:Anastomosis, Surgical / Q000592:standards*; D000818:Animals; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000295:instrumentation* / Q000379:methods*; D003331:Coronary Vessels / Q000601:surgery; D004724:Endoscopy / Q000379:methods; D005260:Female; D008297:Male; D008323:Mammary Arteries / Q000601:surgery; D023421:Models, Animal; D012371:Robotics / Q000379:methods*; D013552:Swine; D017216:Telemedicine / Q000379:methods*