title: Ex situ preparation of left split-liver grafts with left vascular pedicle only: is it safe? A comparative single-center study.
abstract: The procurement of left-lateral-segment grafts from living donors for transplantation in children is performed by retaining only the left branches of the artery and veins. New techniques and the implementation of microsurgery in the transplant operation made this procedure a successful approach. However, controversy persists about using such an approach for division of liver grafts from cadaveric donors, and many teams prefer retaining the main arterial trunk with the left split graft, with or without the main portal vein trunk. Since 1998, in our center, when a donor-liver graft is divided we prefer retaining the main vessels with the right split graft if graft vascular anatomy is favorable. After 1998, 40 liver grafts from cadaveric donors were divided, and all divisions were performed ex situ. This experience was retrospectively reviewed to compare the outcome of left split grafts prepared for implantation with the left vasculature only (group A), or with the main arterial supply (group B). A single vascular complication occurred (one hepatic artery thrombosis in group B). Three patients died (one in group A and two in group B) and three other grafts were lost (one in group A and two in group B). One-year and 3-year graft survival rates were 94% and 86% in group A, and 83% and 83% in group B, respectively (not significantly [NS] different). We conclude that left split grafts can be safely transplanted with the left vascular supply only, provided that division is guided by careful anatomical evaluation and that vascular reconstructions are adequate.
authors.affiliation: Liver Unit, Birmingham Children's Hospital, Birmingham, UK.
authors.forename: Huda M
authors.initials: HM
authors.lastname: Noujaim
authors.forename: Bridgit
authors.initials: B
authors.lastname: Gunson
authors.forename: Darius F
authors.initials: DF
authors.lastname: Mirza
authors.forename: David A
authors.initials: DA
authors.lastname: Mayer
authors.forename: Daniel
authors.initials: D
authors.lastname: Candinas
authors.forename: John A C
authors.initials: JA
authors.lastname: Buckels
authors.forename: Paul
authors.initials: P
authors.lastname: McMaster
authors.forename: Jean
authors.initials: J
authors.lastname: de Ville de Goyet
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006085:Graft Survival; D006801:Humans; D008099:Liver / Q000503:physiopathology; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged