title: Antioxidative and cytotoxic compounds extracted from the sap of Rhus succedanea.
abstract: Two new antioxidative and cytotoxic compounds, 10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone (1) and 10'(Z),13'(E)-heptadecadienylhydroquinone (2), as well as the known 10'(Z)-heptadecenylhydroquinone (3), were isolated from an EtOH extract of the sap of Rhus succedanea. The structures were elucidated by spectral analyses. These compounds showed antioxidative and cytotoxic activities against five cancer cell lines.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.
authors.forename: Pei-Lin
authors.initials: PL
authors.lastname: Wu
authors.forename: Shwu-Bin
authors.initials: SB
authors.lastname: Lin
authors.forename: Cheng-Po
authors.initials: CP
authors.lastname: Huang
authors.forename: Robin Y-Y
authors.initials: RY
authors.lastname: Chiou
mesh_terms: D000465:Algorithms; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular; D015179:Colorectal Neoplasms; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005910:Glioma; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D029045:Rhus / Q000737:chemistry*; D013237:Stereoisomerism; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C471674:10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone; C471675:10'(Z),13'(E)-heptadecadienylhydroquinone; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D006873:Hydroquinones