Effect of 23 valent pneumococcal polysaccharide and Haemophilus influenza conjugated vaccines on the clinical course of otitis media with effusion.
OBJECTIVE
To determine if there is any clinical effect of 23-valent pneumococcal and type B conjugate vaccine on prognosis of otitis media with effusion.


METHODS
All children who have middle ear effusion despite long-standing antibiotherapy with a beta lactamase stable agent were offered for tympanostomy tube insertion between February 1999 and December 2001. Patients who accepted the surgical intervention were operated under general anesthesia and a Shepard grommet-type tympanostomy tube was inserted. Those who refused the surgical intervention were vaccinated with 23-valent pneumococcal and type B conjugate vaccine. State of the middle ear effusion was evaluated at the end of the 12th month in the vaccine group and 1 month after the myringotomy site was healed in the tympanostomy tube insertion group.


RESULTS
Twenty-six children in the vaccine group and 37 children in the tympanostomy tube insertion group proved the inclusion criteria at the end of study. Complete or partial resolution of middle ear effusion was observed in 73.1% of 26 children in the vaccine group and 59.5% of children in the tympanostomy tube insertion group. There was no significant difference between the two groups.


CONCLUSIONS
Vaccination against and type b seems to aid resolution of middle ear effusion in children with otitis media with effusion.
Kiliç
Rahmi
R
ENT Department, Ankara Research and Training Hospital, Turkey. kiliç@tr.net
Safak
Mustafa A
MA
Ozdek
Ali
A
Göçmen
Hakan
H
Kiliç
Dilek
D
Samim
Erdal
E
D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D018073:Haemophilus Vaccines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008876:Middle Ear Ventilation; D010034:Otitis Media with Effusion / Q000517:prevention & control* / Q000601:surgery; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*
D018073:Haemophilus Vaccines; D022242:Pneumococcal Vaccines