[Rapid analysis of biocompatibility with graded test samples exemplified by Ni-NiTi-Ti].
The biocompatibility of nickel-titanium alloys was investigated by single-culture experiments on functionally graded samples with a stepwise change in composition from nickel to titanium, including NiTi shape memory alloy of a 50:50 mixture. This approach permitted a considerable decrease of experimental resources by simultaneously studying a full variation of composition. The results indicate a good biocompatibility for a nickel content up to about 50%. The cells used in the biocompatibility studies comprised human osteoblast-like osteosarcoma cells (SAOS-2, MG-63), primary human osteoblasts (HOB), and murine fibroblasts (3T3).
Bogdanski
D
D
Chirurgische Klinik und Poliklinik, BG Kliniken Bergmannsheil Bochum, Deutschland. denise.bogdanski@ruhr-uni-bochum.de
Köller
M
M
Bram
M
M
Stöver
D
D
Buchkremer
H P
HP
Choi
J
J
Epple
M
M
Muhr
G
G
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005347:Fibroblasts; D006801:Humans; D008422:Materials Testing; D051379:Mice; D009532:Nickel / Q000009:adverse effects* / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology*; D012516:Osteosarcoma; D013329:Structure-Activity Relationship; D014025:Titanium / Q000009:adverse effects* / Q000737:chemistry; D014407:Tumor Cells, Cultured
C040654:titanium nickelide; D009532:Nickel; D014025:Titanium