title: Central retinal vein occlusion and thrombophilia risk factors.
abstract: The purpose of the present study was to investigate the role of risk factors predisposing to thrombosis in patients with central retinal vein occlusion (CRVO). We prospectively examined 37 consecutive patients with CRVO, and 144 healthy controls, for major and potential inherited and acquired thrombophilic risk factors. Among them, only the prevalence of hyperhomocysteinaemia (10/37, 27.0%) and antiphospholipid antibodies positivity (5/37, 13.5%) were significantly higher in patients with respect to controls (5.5%, P < 0.001 and 2.1%, P < 0.01, respectively). Both hyperhomocysteinaemia and antiphospholipid antibodies seem to be associated with CRVO. A search for acquired thrombophilia is advisable in patients with CRVO.
authors.affiliation: Department of Haematology, Thrombosis and Haemostasis, Favaloro University, Buenos Aires, Argentina.
authors.forename: Y P
authors.initials: YP
authors.lastname: Adamczuk
authors.forename: M L
authors.initials: ML
authors.lastname: Iglesias Varela
authors.forename: M E
authors.initials: ME
authors.lastname: Martinuzzo
authors.forename: G S
authors.initials: GS
authors.lastname: Cerrato
authors.forename: R R
authors.initials: RR
authors.lastname: Forastiero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000097:blood* / Q000150:complications / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000209:etiology* / Q000235:genetics; D013927:Thrombosis / Q000209:etiology / Q000235:genetics
chemical_list: D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D001798:Blood Proteins