[Effect of coordinational germanium compounds on enzyme synthesis and activity].
Germanium complexes (IV) with succinic (H2Suc), oxyethyliminodiacetic (H2Oeida) and iminodisuccinic (H4Ids) acids as well as homo- and heteroligand germanium complexes (IV)--products of interaction of triammonium salt of oxyethylidendiphosphonic acid ((NH4)3HL) and oxyacids: tartaric (H4Tart), citric (H4Citr), trioxyglutaric (H4Toglut) acids have been synthesized. Composition of the obtained complexes: [Ge(OH)2(NaSuc)2].2H2O (I); [Ge(OH) (Oeida).H2O].H2O (II); [Ge(OH)2(NaHIds)2] (III); [Ge(OH)2(NH4)3HL) (H2Tart)] (IV); [Ge(OH)2(NH4)3HL) (H2Citr)] (V); [Ge(OH)2(NH4)3HL) (H2Toglut)] (VI); [Ge(OH)2((NH4)2HL)2] (VII); [Ge (OH)2((NH4)2HL)2] (VII); [Ge(OH)2 (H2O)2(NH4) HL] (VIII) has been determined. The capability of the synthesized compounds has been studied to affect synthesis and activity of the following enzymes: collagenase, alpha-N-acetylgalactosaminidase (alpha-GalNAc-ase) and alpha-galactosidase (alpha-Gal-ase). It has been established that the complexes II-VIII activate biosynthesis of alpha-Gal-ase and alpha-GalNAc-ase, while germanium dioxide (IX) and complex I possess considerable inhibiting effect on synthesis of the above enzymes. It has been also established that all the compounds except for IV increased the activity of both alpha-Gal-ase and alpha-GalNAc-ase. All the considered complexes demonstrated similar reaction with respect to collagenase: they inhibited both synthesis and activity.
Seĭfullina
I I
II
Odessa National University, 2 Dvoryanskaya St., Odessa, 65029, Ukraine.
Martsinko
E E
EE
Batrakova
O A
OA
Borzova
N V
NV
Ivanko
E V
EV
Varbanets
L D
LD
D017364:Collagenases / Q000096:biosynthesis / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005857:Germanium / Q000737:chemistry / Q000494:pharmacology*; D006596:Hexosaminidases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*; D007098:Imino Acids / Q000737:chemistry; D061965:Matrix Metalloproteinase Inhibitors; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019802:Succinic Acid / Q000737:chemistry; D013997:Time Factors; D000519:alpha-Galactosidase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*; D048809:alpha-N-Acetylgalactosaminidase
D004791:Enzyme Inhibitors; D007098:Imino Acids; D061965:Matrix Metalloproteinase Inhibitors; D009942:Organometallic Compounds; D005857:Germanium; C040516:germanium oxide; D019802:Succinic Acid; D006596:Hexosaminidases; D000519:alpha-Galactosidase; D048809:alpha-N-Acetylgalactosaminidase; D017364:Collagenases