Thyroid function, autoantibodies, and HLA tissue typing in children with alopecia areata.
A total of 80 Kuwaiti children with alopecia areata (AA), without clinical evidence of thyroid disease, were screened for the presence of thyroid abnormalities, and 50 unrelated children with AA were tissue typed for human leukocyte antigen (HLA) class I and class II antigens. Thyroid abnormalities were detected in 14 children (17.5%). Among these, 11 children (14%) had thyroid autoantibodies. These observations highlight the significance of screening for thyroid abnormalities in children with chronic, recurrent, and/or extensive disease. The Kuwaiti children with AA were observed to have a significant association with HLA B21 (OR 18.850, 95% CI 4.404-80.677), B40 (OR 6.767, 95% CI 1.818-25.181), and HLA B12 (OR 4.833, 95% CI 1.198-19.505) antigens. These findings differed from those reported elsewhere.
Nanda
Arti
A
Asad Al-Hamad Dermatology Center, Al-Sabah Hospital, Salmiya, Kuwait. artinanda@hotmail.com
Alsaleh
Qasem A
QA
Al-Hasawi
Fowzia
F
Al-Muzairai
Ibrahim
I
D000506:Alopecia Areata / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007730:Kuwait; D013959:Thyroid Diseases / Q000150:complications / Q000276:immunology*; D013960:Thyroid Function Tests
D001323:Autoantibodies; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II