title: Alkaloids from the roots of Senecio macedonicus Griseb.
abstract: The new alkaloids 7-,9-diangeloylplatynecine (1) and 8-episarracine N-oxide (2), were isolated and identified from the roots of Senecio macedonicus. Another one, 8-epineosarracine was detected by GC/MS analyses of the crude alkaloid mixture. The cytotoxicity and biological activity of the alkaloids were tested on normal murine spleen lymphocytes and P3U1 mouse myeloma.
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia. christov@orgchm.bas.bg
authors.forename: Veselin
authors.initials: V
authors.lastname: Christov
authors.forename: Bozhanka
authors.initials: B
authors.lastname: Mikhova
authors.forename: Radostina
authors.initials: R
authors.lastname: Alexandrova
authors.forename: Daniela
authors.initials: D
authors.lastname: Dimitrova
authors.forename: Elena
authors.initials: E
authors.lastname: Nikolova
authors.forename: Liuba
authors.initials: L
authors.lastname: Evstatieva
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013154:Spleen / Q000276:immunology
chemical_list: D011763:Pyrrolizidine Alkaloids; C011104:sarracine