Hematological risk factors for coronary heart disease.
Coronary heart disease (CHD) is a leading cause of morbidity and mortality in the developed and developing countries. Several underlying genetic and environmental factors have been implicated in its etiology. Some of the hematological risk factors implicated in the development of coronary heart disease include antithrombin III deficiency, protein C and protein S deficiency, factor V Leiden mutation, prothrombin gene (20210A) mutation hyperhomocystinaemia, elevated factor VIII levels, plasminogen activator inhibitor type 1 and dysfibrinogenaemia. In general, these factors result in thrombosis, thus having a negative effect on the heart and blood vessels. This paper presents an overview of some of the hematological risk factors involved in the development of CHD.
El-Hazmi
Mohsen A F
MA
Medical Biochemistry Department and WHO Collaborating Centre, College of Medicine and King Khalid Hospital, King Saud University, Riyadh, Saudi Arabia. mohsen@ksu.edu.sa
D000991:Antithrombins / Q000172:deficiency; D001424:Bacterial Infections / Q000150:complications; D003327:Coronary Disease / Q000097:blood* / Q000235:genetics*; D005165:Factor V / Q000235:genetics; D005169:Factor VIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006710:Homocysteine / Q000097:blood; D006801:Humans; D009154:Mutation; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors
D000991:Antithrombins; D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; D017293:Protein S; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V; D011516:Prothrombin; D005169:Factor VIII; D005340:Fibrinogen