Clinical features and treatment prognosis of infertile males with robertsonian translocation.
BACKGROUND
The principle of treating male infertility in those with chromosomal aberrations should change according to progress in treatment modalities.


METHODS
In this study, ten patients with Robertsonian translocation were assessed for their cytogenetic and clinical characteristics to establish guidelines for treating these patients.


RESULTS
In 8 of 10 cases, chromosomes 13 and 14 were involved. In 4 of 10 cases (40%), their wives became pregnant, including two spontaneously. All newborns were without any deformities including one boy who was shown to have a normal karyotype.


CONCLUSIONS
Infertility treatment of patients with Robertsonian translocation should be optimistically performed on the basis of proper informed consent.
Kondoh
Nobuyuki
N
Department of Urology, Osaka Central Hospital, Osaka University Medical School, Osaka, Japan. urokon@hyo-med.ac.jp
Matsumiya
Kiyomi
K
Nakamura
Yoshiro
Y
Koga
Minoru
M
Nishimura
Kenji
K
Kitamura
Masaya
M
Takeyama
Masami
M
Okuyama
Akihiko
A
D000328:Adult; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic