Effect of insulin-like growth factor-I (IGF-I) on femoral bone modeling in growing mice.
The time-dependent effects of daily dosing of IGF-I (1.21 mg/g) on the linear growth of the femur were investigated in mice. The femoral length and volume and the number of osteoclasts were significantly greater after IGF-I injection as compared to the non-injected control, suggesting that the IGF-I imbalance might cause a quick turnover cycle of the bone resulting in the altered femoral modeling.
Kawata
Toshitsugu
T
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Tokimasa
Chiyoko
C
Fujita
Tadashi
T
Kaku
Masato
M
Tsutsui
Keisuke
K
Kohno
Shinya
S
Matsuki
Akira
A
Tenjo
Kaoru
K
Ohtani
Junji
J
Motokawa
Masahide
M
Kobayakawa
Takashi
T
Shigekawa
Mao
M
Tanne
Kazuo
K
D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000166:cytology / Q000254:growth & development*; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D007334:Insulin-Like Growth Factor I