Synthesis of radioiodinated aryl iodides via boronate precursors.
Arylboronate esters are converted to iodine-123 labeled aryl iodides using no-carrier-added iodine-123 labeled sodium iodide in the presence of chloramine-T. High yields of radiochemically pure products are obtained.
Kabalka
George W
GW
Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, TN 37966-1600, USA. Kabalka@utk.edu
Akula
Murthy R
MR
Zhang
Jianhua
J
D000840:Anisoles / Q000138:chemical synthesis* / Q000302:isolation & purification; D001896:Boron Compounds / Q000138:chemical synthesis; D001897:Boronic Acids / Q000138:chemical synthesis*; D002700:Chloramines / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis; D007457:Iodine Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D007553:Isotope Labeling / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D000840:Anisoles; D001896:Boron Compounds; D001897:Boronic Acids; D002700:Chloramines; D006846:Hydrocarbons, Halogenated; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; C108415:4-iodoanisole