[Spontaneous and induced variability of Streptomyces aureofaciens--chlortetracycline producer].
Spontaneous and induced variability of Streptomyces aureofaciens strain T[symbol: see text] 633 [symbol: see text] and its variants has been investigated. Correlative relation between the antibiotic formation and colonies morphology was observed. Combined effect of nitrosoguanidine and UV-beams resulted in the obtaining of 27 variants which exceeded activity of strain T[symbol: see text] 633 [symbol: see text] by 30-35% and were stable as to antibiotic biosynthesis during 7-10 generations.
Stryzhkova
H M
HM
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.
Kopeĭko
O P
OP
Lavrinchuk
V Ia
VIa
Bambura
O I
OI
Matseliukh
B P
BP
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002751:Chlortetracycline / Q000096:biosynthesis*; D014644:Genetic Variation; D009154:Mutation; D009604:Nitrosoguanidines / Q000494:pharmacology; D013304:Streptomyces aureofaciens / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism* / Q000528:radiation effects; D014466:Ultraviolet Rays
D000900:Anti-Bacterial Agents; D009604:Nitrosoguanidines; D002751:Chlortetracycline