Polysulfide derivatives from Ferula foetida.
The ethyl acetate-soluble fraction from a methanol extract of Ferula foetida has afforded six new sulfide derivatives, (E)-3-methylsulfinyl-2-propenyl sec-butyl disulfide (foetisulfide A) (1), (Z)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide B) (2), (E)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide C) (3), bis(3-methylthio-2E-propenyl) disulfide (foetisulfide D) (4), 3,4,5-trimethyl-2-thiophenecarboxylic acid (foetithiophene A) (5), 3,4,5-trimethyl-2-(methylsulfinyloxymethyl)thiophene (foetithiophene B) (6), along with six known compounds. The structures of 1-6 were established on the basis of spectroscopic studies, with the elucidation of 5 confirmed by single-crystal X-ray crystallography.
Duan
Hongquan
H
The College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China.
Takaishi
Yoshihisa
Y
Tori
Motoo
M
Takaoka
Shigeru
S
Honda
Gisho
G
Ito
Michiho
M
Takeda
Yoshio
Y
Kodzhimatov
Olimjon K
OK
Kodzhimatov
K
K
Ashurmetov
Ozodbek
O
D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D005309:Ferula / Q000737:chemistry*; D008519:Medicine, Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry / Q000302:isolation & purification*; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification; D014610:Uzbekistan
D013440:Sulfides; D013876:Thiophenes; C032915:polysulfide