title: Usefulness of endoscopic observation of the main duodenal papilla in the diagnosis of sclerosing pancreatitis.
abstract: BACKGROUND
  There are no descriptions of the appearance of the main duodenal papilla in sclerosing pancreatitis. The intent of the present study was to clarify the characteristics of the main duodenal papilla in patients with sclerosing pancreatitis.
  
  
  METHODS
  Macroscopic findings at ERCP with reference to the main duodenal papilla of 17 patients with sclerosing pancreatitis were compared with those of 24 patients with normal ERCP findings, 11 with chronic pancreatitis, 13 with primary sclerosing cholangitis, 21 with pancreatic cancer, and 18 with bile duct cancer. Endoscopic photographs of the papilla were reviewed retrospectively by 3 observers blinded to the underlying pancreaticobiliary pathology. Degree of swelling was scored in all patients. Biopsy specimens from swollen papillae were assessed histopathologically in 3 patients with sclerosing pancreatitis.
  
  
  RESULTS
  Severe swelling of the main duodenal papilla was observed in 7 (41%) of 17 patients with sclerosing pancreatitis. The total score for the degree of swelling in patients with sclerosing pancreatitis was significantly higher than that for patients with a normal ERCP, chronic pancreatitis, primary sclerosing cholangitis, pancreatic cancer, and bile duct cancer (p < 0.01). T-lymphocyte infiltration of the papilla was evident in the biopsies from 3 patients with sclerosing pancreatitis.
  
  
  CONCLUSIONS
  A swollen main duodenal papilla was a characteristic finding in patients with sclerosing pancreatitis. T-lymphocyte infiltration is present in the swollen main duodenal papilla. These features may be useful in the diagnosis of sclerosing pancreatitis.
authors.affiliation: The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Unno
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Saegusa
authors.forename: Mana
authors.initials: M
authors.lastname: Fukushima
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hamano
mesh_terms: D000368:Aged; D014670:Ampulla of Vater / Q000000981:diagnostic imaging* / Q000473:pathology; D002760:Cholangiopancreatography, Endoscopic Retrograde; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010195:Pancreatitis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism