title: Cutaneous EBV-related lymphoproliferative disorder in a 15-year-old boy with AIDS: an unusual clinical presentation.
abstract: Lymphomas are a well-known malignancy in individuals with human immunodeficiency virus type 1 (HIV-1) infection. Most lymphomas are of B-cell lineage and cutaneous involvement is rare. Cutaneous T-cell lymphomas have been previously described in adults with HIV-1 infection but are exceptional in HIV-1 infected-children. The authors report here the extremely rare case of a large-cell cutaneous lymphoproliferation of T-cell lineage expressing Epstein-Barr virus (EBV) antigens in a 15-year-old boy with AIDS and his uncommon clinical presentation. The atypical clinical evolution with a nonaggressive treatment emphasizes that for immunosuppressed patients, the diagnosis of immunosuppression-related lymphoproliferative disorder should be considered before giving the diagnosis of malignant lymphoma when tumoral lymphoid cells express EBV antigens.
authors.affiliation: Department of Pathology, Hôpital Necker-Enfants Malades, 149 rue de Sevres, 75015 Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Fardet
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
authors.forename: Nicole
authors.initials: N
authors.lastname: Brousse
authors.forename: Christine
authors.initials: C
authors.lastname: Bodemer
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fraitag
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015703:Antigens, CD / Q000032:analysis; D023241:Antiretroviral Therapy, Highly Active; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections; D015329:Gene Rearrangement, T-Lymphocyte; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D019469:Indinavir / Q000627:therapeutic use; D019259:Lamivudine / Q000627:therapeutic use; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis* / Q000821:virology; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery / Q000821:virology; D008297:Male; D012367:RNA, Viral / Q000032:analysis; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000175:diagnosis; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery / Q000821:virology; D018119:Stavudine / Q000627:therapeutic use; D065227:Transfusion Reaction; D014763:Viral Matrix Proteins / Q000032:analysis
chemical_list: D019380:Anti-HIV Agents; D015703:Antigens, CD; C037662:EBV-associated membrane antigen, Epstein-Barr virus; C099537:Epstein-Barr virus encoded RNA 1; D017320:HIV Protease Inhibitors; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D014763:Viral Matrix Proteins; D019259:Lamivudine; D019469:Indinavir; D018119:Stavudine