Comparative mapping of CDY and DAZ in higher primates.
The human male specific expressed gene families CDY and DAZ are known to be repetitively clustered in the Y-specific region of the human Y chromosome. Comparative FISH-mapping of DNA clones specific for CDY and DAZ resulted in a Y-specific but diverse signal pattern within the non-recombining region of the Y-chromosomes of human and great apes. It can be concluded that the non-recombining part of the Y-chromosomes including CDY and DAZ, was exposed to species-specific amplifications, diversifications and rearrangements. Evolutionary fast fixation of any of these variations was possible as long as they did not interfere with male fertility.
Wimmer
R
R
Institute of Human Genetics and Anthropology, University of Freiburg, Freiburg, Germany.
Kühl
H
H
Röttger
S
S
Schempp
W
W
D000818:Animals; D000075364:Deleted in Azoospermia 1 Protein; D005819:Genetic Markers; D006071:Gorilla gorilla / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D005810:Multigene Family / Q000235:genetics*; D009687:Nuclear Proteins; D002679:Pan troglodytes / Q000235:genetics; D011148:Pongo pygmaeus / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D013045:Species Specificity; D014998:Y Chromosome
C118459:CDY1 protein, human; C485564:CDY2A protein, human; C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D005819:Genetic Markers; D009687:Nuclear Proteins; D011506:Proteins; D016601:RNA-Binding Proteins