Heart rate changes accompanying jaw movement Pavlovian conditioning in rabbits: concomitant blood pressure adjustments and effects of peripheral autonomic blockade.
Two experiments were conducted to ascertain the cardiovascular accompaniments of differential Pavlovian jaw movement (JM) conditioning. The first examined the blood pressure (BP) changes that accompany the tachycardiac conditioned responses (CRs) associated with JM conditioning. The BP response in all instances consisted of a depressor response that was greater to the reinforced CS+ than CS-, although the magnitude of the CR was quite small. The second experiment determined the effects of peripheral autonomic antagonists on the cardiac accelerations associated with JM conditioning. It was found that the peripheral vagal antagonist methyl scopolamine completely abolished responses to both CS+ and CS-, whereas atenolol, a beta adrenergic antagonist, augmented the response, compared to saline control injections. The JM responses were also affected by the autonomic blockades, with minimal responding occurring in the scopolamine group but slightly more JM CRs in the atenolol group, compared to saline control animals. These results suggest that the major cardiovascular response to an appetitive stimulus, which evokes JM conditioning, consists of cardiac accelerations with the BP depressor responses playing a minimal, if any, role. Moreover, these conditioned cardiac increases appear to be due solely to the release of vagal inhibition.
Powell
D A
DA
Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center, Columbia, SC, 29209-1639, USA. donnie.powell@med.va.gov
McLaughlin
Joselyn
J
Churchwell
John
J
Elgarico
Teddy
T
Parker
Adrian
A
D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D001262:Atenolol / Q000494:pharmacology; D001340:Autonomic Nerve Block; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008409:Mastication / Q000187:drug effects / Q000502:physiology*; D019832:N-Methylscopolamine / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects; D011817:Rabbits; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology
D001262:Atenolol; D019832:N-Methylscopolamine