A recipe for ridding synapses of the ubiquitous AMPA receptor.
Getting AMPA receptors into and out of synapses represents an important mechanism for changing synaptic strength, but the signals that target AMPA receptors for removal from the synaptic membrane are incompletely understood. A recent study in Ceanorhabditis elegans suggests that ubiquitination of AMPA receptors is one important signal that targets these receptors for endocytosis.
Turrigiano
Gina G
GG
Dept of Biology MS 08, Brandeis University, 415 South Street, Waltham, MA 02454, USA. turrigiano@brandeis.edu
D000818:Animals; D004705:Endocytosis / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D018091:Receptors, AMPA / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism
D018091:Receptors, AMPA; D025801:Ubiquitin