title: Pemphigus foliaceus in a goat.
abstract: A 7-year-old-female goat was referred with a 3-month history of chronic dermatitis, which partially responded to combined corticosteroid and antibiotic therapy. At dermatological examination diffuse alopecia, pustules and crusts were observed on the head, neck, dorsum and perianal area. Dermatophyte culture and skin scrapings were negative. Trichoscopic examination revealed a concurrent infestation with Damalinia caprae, which was successfully treated with ivermectin. Cytological examination of pus from intact pustules revealed nondegenerate neutrophils, absence of bacteria and numerous nucleated, irregularly shaped keratinocytes. Histopathological examination of lesional skin revealed intracorneal pustules containing neutrophils and acantholytic cells, and a mixed cell superficial perivascular dermatitis. Immunohistochemical stains of lesional skin showed intercellular IgG deposits in the spinous layer. Remission of the dermatitis was obtained with injectable dexamethasone-21-isonicotinate, every two months for one year. This is the first report to describe the cytological appearance of impression smears from intact pustules of pemphigus foliaceus in a goat and to document the presence of IgG deposits in lesional skin by means of immunohistochemistry.
authors.affiliation: Studio Dermatologico Veterinario, Milan, Italy.
authors.forename: Ersilia
authors.initials: E
authors.lastname: Pappalardo
authors.forename: Francesca
authors.initials: F
authors.lastname: Abramo
authors.forename: Chiara
authors.initials: C
authors.lastname: Noli
mesh_terms: D000505:Alopecia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D003908:Dexamethasone Isonicotinate / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D015511:Goat Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006041:Goats; D007150:Immunohistochemistry / Q000662:veterinary; D007267:Injections / Q000662:veterinary; D007559:Ivermectin / Q000627:therapeutic use; D010373:Lice Infestations / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D010392:Pemphigus / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008003:Phthiraptera
chemical_list: D005938:Glucocorticoids; D007559:Ivermectin; D003908:Dexamethasone Isonicotinate