New disc-based technologies for diagnostic and research applications.
The role of genotypic analysis in disease diagnostics and drug response assessment is continually expanding. New genomic discoveries combined with new, novel technologies may provide a greater range of testing capabilities in the near future. We describe the application of nanotechnology, in which DNA microarrays have been placed in a microchannel environment that can be read and analyzed in an optical (CD/DVD) disc drive system. The potential exists to combine molecular and immunological applications together into a rapid, low-cost, high-capacity screening platform. The relevance of this technology is discussed in respect to infectious agent detection, pharmacogenomics, neurogenomics and genetic variations associated with neurologic diseases.
Barathur
Raj
R
Burstein Technologies Inc., Irvine, California 92618, USA. rajbarathur@bursteinlabs.com
Bookout
Jack
J
Sreevatsan
Srinand
S
Gordon
John
J
Werner
Martina
M
Thor
Gautam
G
Worthington
Mark
M
D005821:Genetic Techniques; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007158:Immunologic Techniques; D008967:Molecular Biology / Q000379:methods; D009422:Nervous System Diseases / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods