Modern concept on the role of phagocytes in the pathogenesis of complications during pregnancy.
Here we review modern concept of the role of phagocytes, the key cell component of natural immunity, in the course of pregnancy and in the pathogenesis of its complications. Phagocytes contribute to the development, maintenance, and favorable outcome of pregnancy. These cells play a role in the pathogenesis of various pregnancy complications, including fetal growth retardation, late gestosis, and intrauterine infections. The understanding of the pathophysiological mechanisms that occur in the mother-placenta-fetus system would allow us to improve diagnostic procedures, perform pathogenetically substantiated therapy, and decrease the incidence of obstetrical complications.
Sukhikh
G T
GT
Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Safronova
V G
VG
Van'ko
L V
LV
D000026:Abortion, Habitual / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000276:immunology; D002821:Chorioamnionitis / Q000276:immunology; D005260:Female; D005317:Fetal Growth Retardation / Q000276:immunology; D006801:Humans; D010586:Phagocytes / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011273:Pregnancy, Prolonged / Q000276:immunology