title: Gravimetrically controlled efficacy of subcorial curettage: a prospective study for treatment of axillary hyperhidrosis.
abstract: BACKGROUND
  Botulinum toxin A (BTX-A) proved to be effective for the treatment of axillary hyperhidrosis by means of gravimetry. Quantitatively controlled studies for surgical treatment are lacking so far.
  
  
  OBJECTIVE
  To prospectively test the efficacy of subcorial axillary curettage by gravimetric evaluation of pre- and postsurgical sweat rates.
  
  
  METHODS
  Conservatively pretreated patients received subcorial curettage under tumescent local anesthesia using a sharp spoon. Sweat rates of each axilla were determined gravimetrically before and 4-8 weeks after surgery. Evaluation was performed with respect to baseline sweat rates greater than 50 mg/min (group A), greater than 25 and less than 50 mg/min (group B), and less than 25 mg/min (group C). Side effects and patients' ratings were also recorded.
  
  
  RESULTS
  Of 42 treated patients, 38 could be evaluated completely. In 29 axillae of group A (high sweat rates), an average reduction from the baseline of 85.6 mg/min to 21.6 mg/min could be achieved (P <.0001). Corresponding values for 22 axillae of group B (medium sweat rates) were 36.8 mg/min and 16.5 mg/min (P <.0001). In 25 axillae with low sweat rates (group C), a significant reduction in sweat rates could not be achieved. The results remained almost stable during a median follow-up of 11 months (range 4-24 months). Only minor side effects were observed and patient satisfaction was high in groups A and B.
  
  
  CONCLUSIONS
  Subcorial curettage is an effective treatment of axillary hyperhidrosis for patients with baseline sweat rates greater than 25 mg/min.
authors.affiliation: Department of Dermatology, University of Mainz, Mainz, Germany. Thomas.Proebstle@web.de
authors.forename: T M
authors.initials: TM
authors.lastname: Proebstle
authors.forename: V
authors.initials: V
authors.lastname: Schneiders
authors.forename: J
authors.initials: J
authors.lastname: Knop
mesh_terms: D000328:Adult; D001365:Axilla; D003475:Curettage; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000601:surgery*; D015187:Lipectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011183:Postoperative Complications; D011446:Prospective Studies; D013542:Sweat; D016896:Treatment Outcome