title: The differential expression of corticotropin releasing factor and its binding protein in the gerbil hippocampal complex following seizure.
abstract: Considerable attention has been focused on the role of corticotropin releasing factor (CRF) as well as CRF-binding protein (CRF-BP) in neuropsychiatric disorders and neurodegenerative diseases including epilepsy. Therefore, in the present study, we investigated the temporal and spatial alteration of CRF and CRF-BP in the gerbil hippocampal complex in order to characterize the possible changes and associations with different sequelae of spontaneous seizure in these animals. CRF immunoreactivity was shown in the interneurons of the hippocampal complex at 30 min following seizure. Additionally, alteration of CRF-BP immunoreactivity was restricted to the entorhinal cortex after seizure. These results indicate some factors for consideration. First, in the gerbil hippocampal complex, the delayed increase of CRF immunoreactivity, in spite of its excitatory function, may attenuate seizure activity, but may not do so in epileptogenesis. Second, in contrast to the hippocampal complex, the increase in CRF-BP immunoreactivity in the entorhinal cortex following seizure may participate in feedback inhibitory modulation.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do 200-702, South Korea.
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: Dong-Il
authors.initials: DI
authors.lastname: Choi
authors.forename: In-Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Jun-Gyo
authors.initials: JG
authors.lastname: Suh
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Oh
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis* / Q000235:genetics; D018728:Entorhinal Cortex / Q000378:metabolism*; D005246:Feedback; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D007395:Interneurons / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D010812:Physical Stimulation / Q000009:adverse effects; D012333:RNA, Messenger / Q000096:biosynthesis; D012640:Seizures / Q000209:etiology / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C067133:corticotropin releasing factor-binding protein; D003346:Corticotropin-Releasing Hormone