Steroid and antibacterial steroidal glycosides from marine green alga Codium iyengarii Borgesen.
The ethyl acetate soluble part of methanolic extract of marine green alga Codium iyengarii collected from Karachi coast of Arabian Sea afforded a new steroid ([structure: see text], iyengadione) and two new steroidal glycosides [iyengaroside-A ([structure: see text]) and B ([structure: see text])] along with clerosterol galactoside ([structure: see text]). Their structures were elucidated with the aid of 1D-NMR spectroscopy and reconfirmed through HMBC experiments. The bactericidal activity of [structure: see text] was also explored and found positive response from iyengaroside-A ([structure: see text]) and clerosterol galactoside ([structure: see text]).
Ali
Muhammad Shaiq
MS
HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. hej@digicom.net.pk
Saleem
Muhammad
M
Yamdagni
Raghav
R
Ali
Muhammad Ashfaq
MA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D000460:Chlorophyta / Q000737:chemistry*; D004121:Dimethyl Sulfoxide; D005697:Galactosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005697:Galactosides; D006027:Glycosides; D013256:Steroids; C472632:clerosterol galactoside; C472629:iyengadione; C472630:iyengaroside A; C472631:iyengaroside B; D004121:Dimethyl Sulfoxide