Complete remission of Bomirski Ab amelanotic melanoma in hamsters treated with the angiogenesis inhibitor TNP-470.
The growth of solid tumors and their metastasis is dependent on the development of new blood vessels (angiogenesis). In our previous studies it was found that angiogenesis inhibitor TNP-470 acting systematically can decrease the rate of growth of transplantable Bomirski Abmelanoma in hamsters. In this study we applied TNP-470 (30 mg/kg) peritumorally from the day when tumor was palpable over 10 days, once daily. Animals were killed 6 months later and examination by autopsy and histological preparations showed the complete remission of transplanted tumor and the lack of metastasis. Thus, Ab melanoma can be effectively cured with TNP-470 angiogenesis inhibitor when the substance is applied locally.
Myśliwski
A
A
Department of Histology and Immunology; University of Gdansk, Gdansk, 80-210 Poland. anmys@amedec.amg.gda.pl
Koszałka
P
P
Bigda
J
J
Szmit
E
E
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D003510:Cyclohexanes; D008297:Male; D018328:Melanoma, Amelanotic / Q000628:therapy*; D008647:Mesocricetus; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D012074:Remission Induction; D012717:Sesquiterpenes / Q000494:pharmacology*; D013997:Time Factors
D020533:Angiogenesis Inhibitors; D003510:Cyclohexanes; D012717:Sesquiterpenes; D000077609:O-(Chloroacetylcarbamoyl)fumagillol