Age-related peculiarities of the effect of alpha-adrenoreceptor blockade on cardiac function in rats.
Blockade of alpha(1)-adrenoreceptors with prazosin produces bradycardia. The degree of this bradycardia in rats depends on age. In adult (20-week-old) rats bradycardia is pronounced, in 3-week-old rats it is insignificant, and in 1-week-old rats bradycardia does not develop. Prazosin moderates bradycardia induced by vagal stimulation in rats of different age.
Ziyatdinova
N I
NI
Department of Normal Physiology, Kazan' State Medical University.
Zefirov
A L
AL
Zefirov
T L
TL
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D001919:Bradycardia / Q000139:chemically induced*; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013318:Stroke Volume / Q000187:drug effects; D014630:Vagus Nerve / Q000502:physiology
D000317:Adrenergic alpha-Antagonists; D011224:Prazosin