title: Latent cerebral hypoperfusion in a boy with persistent nephrotic syndrome.
abstract: Pediatricians are often faced with both bad temper and decreased daily activity in children with persistent nephrotic syndrome. These problems, which might affect both mental and physical development, have been explained as a consequence of general fatigue due to systemic edema and/or long-term hospitalization. However, other factors, such as cerebral hypoperfusion, may be involved. We experienced a case of a boy with steroid-resistant nephrotic syndrome who showed diffuse cerebral hypoperfusion on single photon emission computed tomography. Diffuse cerebral hypoperfusion dramatically resolved as the nephrotic syndrome remitted. His bad temper, decreased daily activity, and delay of speech and motor development also improved. In our patient, cerebral hypoperfusion might have been associated with his mental problems, physical problems, and delayed development of speech.
authors.affiliation: Department of Pediatrics, Yokohama City University Medical Center, 4-57, Urafune-cho, Minami-ku, 232-0024 Yokohama, Japan. sk-ito@tb3.so-net.ne.jp
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ito
authors.forename: Atsuo
authors.initials: A
authors.lastname: Nezu
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masami
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Yukoh
authors.initials: Y
authors.lastname: Aihara
authors.forename: Shumpei
authors.initials: S
authors.lastname: Yokota
mesh_terms: D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D002675:Child, Preschool; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D019964:Mood Disorders / Q000209:etiology; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: C025429:methyl prednisolonate; D016572:Cyclosporine; D011239:Prednisolone