title: Genetics of ankylosing spondylitis.
abstract: Ankylosing spondylitis is a common inflammatory rheumatic disease. Both susceptibility to and clinical manifestations of the disease are highly heritable. Although some genes, notably HLA-B27, have been implicated in susceptibility to the disease, the genetics of the condition are complex and many more genes involved in the condition await discovery.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Spondyloarthritis and Bone Disease Research Group, Oxford, United Kingdom. mbrown@well.ox.ac.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Brown
authors.forename: B P
authors.initials: BP
authors.lastname: Wordsworth
authors.forename: J D
authors.initials: JD
authors.lastname: Reveille
mesh_terms: D002874:Chromosome Mapping; D015796:HLA-B27 Antigen / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000503:physiopathology
chemical_list: D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains