title: Detoxification of terpinolene by plant pathogenic fungus Botrytis cinerea.
abstract: Detoxification of an antifungal monoterpene terpinolene (1) by the plant pathogenic fungus Botrytis cinerea afforded hydroxlyated metabolites 2,3-dihydro-3beta,6beta-dihydroxy-terpinolene (2) (39%) and 2,3-dihydro-1alpha,3alpha-dihydroxy-terpinolene (3) (20%), respectively. Terpinolene showed good levels of antifungal activity while both the metabolites were inactive against another plant pathogenic fungus Cladosporium herbarun.
authors.affiliation: International Centre for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan.
authors.forename: Afgan
authors.initials: A
authors.lastname: Farooq
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-ur-Rahman
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tahara
authors.forename: K Hüsnü Can
authors.initials: KH
authors.lastname: Başer
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirci
mesh_terms: D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D020171:Botrytis / Q000378:metabolism*; D002963:Cladosporium / Q000187:drug effects; D000081005:Cyclohexane Monoterpenes; D008658:Inactivation, Metabolic; D010935:Plant Diseases / Q000382:microbiology; D010944:Plants / Q000382:microbiology*; D013729:Terpenes / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000081005:Cyclohexane Monoterpenes; D013729:Terpenes; C027009:terpinolene