title: Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
abstract: High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan. oka@md.okayama-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Oka
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ouchida
authors.forename: Maho
authors.initials: M
authors.lastname: Koyama
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Ogama
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takada
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Nobuya
authors.initials: N
authors.lastname: Ohara
authors.forename: Eisaku
authors.initials: E
authors.lastname: Kondo
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Junjiro
authors.initials: J
authors.lastname: Tsuchiyama
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimizu
authors.forename: Tadaatsu
authors.initials: T
authors.lastname: Akagi
mesh_terms: D000208:Acute Disease; D001483:Base Sequence; D019175:DNA Methylation; D015973:Gene Expression Regulation, Leukemic; D020868:Gene Silencing; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007938:Leukemia / Q000201:enzymology / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology / Q000235:genetics; D007951:Leukemia, Myeloid / Q000201:enzymology / Q000235:genetics; D019656:Loss of Heterozygosity; D016399:Lymphoma, T-Cell / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000235:genetics; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C509249:PTPN6 protein, human; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases