H-channels in epilepsy: new targets for seizure control?
Hyperpolarization-activated cation channels (h-channels) are key regulators of neuronal excitation and inhibition, and have a rich diversity of subunit composition, distribution, modulation and function. Recent results indicate that the behavior of h-channels can be altered significantly by seizures. The activity-dependent, short-term and long-term plasticity of h-channels can, in turn, modulate neuronal excitability. The reciprocal interactions between neuronal activity and h-channels indicate that these ion channels could be promising novel targets for anti-epileptic therapies.
Chen
Kang
K
Dept of Anatomy & Neurobiology, University of California Irvine, 92697-1280, USA.
Aradi
Ildiko
I
Santhakumar
Vijayalakshmi
V
Soltesz
Ivan
I
D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D054815:Cyclic Nucleotide-Gated Cation Channels; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000037:antagonists & inhibitors*; D009419:Nerve Tissue Proteins; D009473:Neuronal Plasticity / Q000187:drug effects; D015221:Potassium Channels
D000927:Anticonvulsants; D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D015221:Potassium Channels