title: Zinc availability from zinc lipoate and zinc sulfate in growing rats.
abstract: The purpose of this study was to investigate the effect of zinc lipoate and zinc sulfate on zinc availability in growing rats. 6 . 6 male albino rats were fed purified diets based on corn starch, egg albumen, sucrose, soy bean oil and cellulose over a 4-week period (diet Ia: 10 mg Zn/kg as zinc sulfate, diet Ib: 10 mg Zn/kg as zinc lipoate, diet IIa: 10 mg Zn/kg as zinc sulfate +0.4% phytic acid, diet IIb: 10 mg Zn/kg as zinc lipoate +0.4% phytic acid, diet IIIa: 20 mg Zn/kg as zinc sulfate + 0.4% phytic acid, diet IIIb: 20 mg Zn/kg as zinc lipoate + 0.4% phytic acid). Zinc lipoate and zinc sulfate both proved to be highly available zinc sources. When 0.4% phytic acid were present in the diets, apparent zinc absorption was generally depressed but was higher from zinc lipoate in tendency than from zinc sulfate. Comparable results were evident for femur zinc, plasma zinc and metallothionein concentrations in liver tissues. This indicates that zinc lipoate could be a valuable zinc source under conditions of low zinc availability. Nevertheless the absence or presence of phytic acid was a more important factor influencing zinc availability than the type of zinc source investigated.
authors.affiliation: Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-University Giessen, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Walter
authors.forename: Klaus
authors.initials: K
authors.lastname: Krämer
authors.forename: Erika
authors.initials: E
authors.lastname: Most
authors.forename: Josef
authors.initials: J
authors.lastname: Pallauf
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001835:Body Weight; D005269:Femur / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D010833:Phytic Acid / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000493:pharmacokinetics*; D015032:Zinc / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D019287:Zinc Sulfate / Q000493:pharmacokinetics*
chemical_list: D008063:Thioctic Acid; D019287:Zinc Sulfate; D010833:Phytic Acid; D008668:Metallothionein; D000469:Alkaline Phosphatase; D015032:Zinc