In vitro killing effect of moxifloxacin on clinical isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole.
The time-kill effect of moxifloxacin on 20 genetically distinct isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole was studied. The majority (80%) were killed by a concentration equivalent to four times the MIC; the MIC induced a transient decrease in bacterial counts at 4 h, followed by regrowth. No effect was detected in four isolates. These results merit further clinical consideration.
Giamarellos-Bourboulis
Evangelos J
EJ
4th Department of Internal Medicine, Medical School, University of Athens, Greece. giamarel@internet.gr
Karnesis
Lazaros
L
Galani
Irene
I
Giamarellou
Helen
H
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D011804:Quinolines; D020615:Stenotrophomonas maltophilia / Q000187:drug effects* / Q000235:genetics; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000077266:Moxifloxacin