title: A simulation to evaluate screening for Helicobacter pylori infection in the prevention of peptic ulcers and gastric cancers.
abstract: A discrete event simulation model has evaluated a screening programme for Helicobacter pylori infection (H. pylori) in which individuals under the age of 50 years would be screened once. Eradication of H. pylori would reduce the peptic ulcer risk immediately and the gastric cancer risk after a fixed delay. The data were derived from published databases and peer reviewed papers. The simulation model, using variance reduction techniques, predicted that a screening programme would reduce morbidity and deaths but could cost around 19 million pounds for England and Wales in the first year of screening. A factorial design analysis showed the sensitivity of key variables. An increase in the opportunistic testing was found significantly to reduce the impact of screening.
authors.affiliation: School of Management, University of Southampton, UK. rmd@soton.ac.uk
authors.forename: Ruth
authors.initials: R
authors.lastname: Davies
authors.forename: David
authors.initials: D
authors.lastname: Crabbe
authors.forename: Paul
authors.initials: P
authors.lastname: Roderick
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Goddard
authors.forename: James
authors.initials: J
authors.lastname: Raftery
authors.forename: Praful
authors.initials: P
authors.lastname: Patel
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004739:England / Q000453:epidemiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000191:economics / Q000706:statistics & numerical data*; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D014852:Wales / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents