title: Massive hepatosplenomegaly in a child with malaria.
abstract: Hypermalarial splenomegaly syndrome (HMS) usually occurs in adults living in malaria-endemic areas. A 7-year-old girl presented with a 7-week history of gradual distention of the abdomen and low grade fever, 8 months after traveling to Ghana, and was subsequently diagnosed with HMS. Presentation at such a young age after very brief exposure to a malaria-endemic area has not been described previously.
authors.affiliation: Department of Pediatrics, Newham General Hospital, London, UK.
authors.forename: Shamez
authors.initials: S
authors.lastname: Ladhani
authors.forename: Efunbo
authors.initials: E
authors.lastname: Dosekun
authors.forename: Vidya
authors.initials: V
authors.lastname: Patel
authors.forename: Delane
authors.initials: D
authors.lastname: Shingadia
mesh_terms: D000367:Age Factors; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002648:Child; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005869:Ghana; D006529:Hepatomegaly / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology; D016778:Malaria, Falciparum / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D002727:Proguanil / Q000627:therapeutic use; D011739:Pyrimethamine / Q000627:therapeutic use; D011803:Quinine / Q000627:therapeutic use; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D013413:Sulfadoxine / Q000627:therapeutic use; D013997:Time Factors; D014195:Travel
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011803:Quinine; D002727:Proguanil; D011739:Pyrimethamine