title: Treatment of heart failure with autologous skeletal myoblasts.
abstract: BACKGROUND
  The management of patients with heart failure is a daily challenge for cardiologists and cardiac surgeons. Pharmacotherapy, atrio-biventricular resynchronization, myocardial revascularization, valve repair techniques, latissimus dorsi cardiomyopathy, acorn cardiac support device, heart transplantation and mechanical assist devices do not cover all the needs. The recent progress in cellular and molecular biology allows the development of new therapies for heart failure.
  One of the most innovative consists in the transplantation of autologous ex-vivo expanded cells into the myocardium for heart muscle regeneration. This approach is called "cellular cardiomyoblasty".
authors.affiliation: Department of Cardiac Surgery, Pompidou and Broussais Hospitals, University of Paris, France. j.chachques@brs.ap-hop-paris.fr
authors.forename: Juan C
authors.initials: JC
authors.lastname: Chachques
authors.forename: Barbara
authors.initials: B
authors.lastname: Cattadori
authors.forename: Jesus
authors.initials: J
authors.lastname: Herreros
authors.forename: Felipe
authors.initials: F
authors.lastname: Prosper
authors.forename: Jorge C
authors.initials: JC
authors.lastname: Trainini
authors.forename: Didier
authors.initials: D
authors.lastname: Blanchard
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Fabiani
authors.forename: Alain
authors.initials: A
authors.lastname: Carpentier
mesh_terms: D000818:Animals; D001706:Biopsy; D002304:Cardiac Pacing, Artificial; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology / Q000601:surgery*; D018421:Cardiomyoplasty / Q000379:methods*; D002469:Cell Separation; D002470:Cell Survival; D002478:Cells, Cultured; D003470:Culture Media; D004452:Echocardiography; D015150:Echocardiography, Doppler; D016228:Endothelial Growth Factors / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D008222:Lymphokines / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000166:cytology; D032448:Myoblasts, Skeletal / Q000637:transplantation*; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000503:physiopathology / Q000601:surgery*; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000601:surgery*; D012038:Regeneration; D012756:Sheep; D013318:Stroke Volume; D013997:Time Factors; D014182:Transplantation, Autologous; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D018487:Ventricular Dysfunction, Left
chemical_list: D003470:Culture Media; D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors