title: Plasma concentrations and role of macrophage inflammatory protein-1alpha during chronic Schistosoma mansoni infection in humans.
abstract: Chemokines play an important role during granulomatous inflammation in murine models of Schistosoma mansoni infection. Here, the expression and possible roles of chemokines during human S. mansoni infection were examined. Compared with uninfected individuals, infected patients had elevated plasma concentrations of macrophage inflammatory protein (MIP)-1alpha, RANTES (regulated on activation, normally T cell-expressed and secreted), and eotaxin. Concentrations of macrophage-derived chemokine, eotaxin-2, monocyte chemotactic protein-1, growth-related oncogene, and interleukin-8 were similar between the 2 groups. When subjects were grouped according to disease severity, individuals with a plasma MIP-1alpha concentration >400 pM had a 10-times greater risk of having the more severe hepatosplenic form of disease. In the in vitro granuloma reaction, greater concentrations of MIP-1alpha were produced by cells of patients with hepatosplenic disease than cells of patients with intestinal disease. Pretreatment with a chemokine receptor antagonist attenuated the enhanced in vitro reaction seen with cells derived from patients with hepatosplenic disease. MIP-1alpha may not only mark a subset of patients with a greater risk of having more severe disease but also play a relevant pathophysiological role in human schistosomiasis.
authors.affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Patrícia L
authors.initials: PL
authors.lastname: Falcão
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Correa-Oliveira
authors.forename: Lúcia A O
authors.initials: LA
authors.lastname: Fraga
authors.forename: André
authors.initials: A
authors.lastname: Talvani
authors.forename: Amanda E I
authors.initials: AE
authors.lastname: Proudfoot
authors.forename: Tim N C
authors.initials: TN
authors.lastname: Wells
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Williams
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Jose
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D000818:Animals; D054413:Chemokine CCL11; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000097:blood; D019742:Chemokines, CC / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000097:blood* / Q000502:physiology; D008297:Male; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000503:physiopathology*
chemical_list: C515456:CCL11 protein, human; D054413:Chemokine CCL11; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins