title: Pine resin and biopin ointment: effects of water-soluble fractions on cytokine production by peripheral blood neutrophils.
abstract: We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.
authors.affiliation: Institute of High-Purity Biological Preparations, St. Petersburg.
authors.forename: A S
authors.initials: AS
authors.lastname: Simbirtsev
authors.forename: V G
authors.initials: VG
authors.lastname: Konusova
authors.forename: G Sh
authors.initials: GSh
authors.lastname: McHedlidze
authors.forename: B A
authors.initials: BA
authors.lastname: Paramonov
authors.forename: V Yu
authors.initials: VY
authors.lastname: Chebotarev
mesh_terms: D001708:Biopterins / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009824:Ointments; D012116:Resins, Plant / Q000008:administration & dosage / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D007378:Interleukins; D009824:Ointments; D012116:Resins, Plant; D014409:Tumor Necrosis Factor-alpha; D001708:Biopterins; C013893:rosin