[Assessment of the rhythm of lymphocyte stimulation and suppression as a criterion of prognosis of the effects of immunomodulatory drugs].
The authors discuss mechanisms of action of immunocorrectors the targets of which are various populations of antigen-presenting lymphoid cells and approaches to application of modulators with different mechanisms of action in disease. To assess a long-term effect of the drug which produces an oscillatory effect (activation/suppression) on T and B cell activity, competitive relations between T and B cells should be tested and taken into account. Common practice of immunocorrection on the basis of T cell activity without consideration of the functional state of other lymphoid sets, especially B cells, deteriorates efficacy of immunocorrection. It is necessary to know the time of T- and B-cell activation and suppression to schedule combined use of drugs with different mechanisms of action.
Nezhinskaia
G I
GI
Sapronov
N S
NS
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects* / Q000276:immunology; D008211:Lymphocyte Cooperation / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000276:Adjuvants, Immunologic