Synthesis of polyamides containing N-methylpyrrole and N-methylimidazole and their anticancer activity.
Three hairpin polyamides were designed and synthesized by a haloform reaction and DCC/HOBt coupling reaction without amino protection and deprotection. Their anticancer activity were investigated with three kinds of cell lines--hepatic carcinoma, lung carcinoma and gastric carcinoma, and the values of IC50 were at range of 10(-7) to approximately 10(-8) M.
Yuan
Gu
G
Department of Chemistry, Ministry of Education, College of Chemistry, Peking University, Beijing, PR China.
Xiao
Junhua
J
Huang
Weiqiang
W
Tang
Feili
F
Zhou
Yawei
Y
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009757:Nylons / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007093:Imidazoles; D009757:Nylons; D011758:Pyrroles; C096654:N-methylpyrrole; C018100:1-methylimidazole