title: [Influence of multiplicity of immunizations of children with inactivated influenza vaccine on immune response and the effectiveness of protection].
abstract: The formation of immunity and epidemiological effectiveness of inactivated influenza vaccines in children, regularly immunized against influenza for three years, were evaluated. The study revealed that a year after each immunization the number of children having antibodies in liters regarded as protective decreased 2-2.5 times. At the periods of epidemics morbidity rate among the vaccines dynamically decreased in these years 1.3, 2.0 and 2.8 times. Considering that a year after the second immunization a high immune stratum (60-78%) was retained in the group under study, we propose that annual immunization of the same children be limited by a period of three years, followed by an interval of one year.
authors.affiliation: Urals State Medical Academy, Regional Center of Sanitary and Epidemiological Surveillance, Yekaterinburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Slobodniuk
authors.forename: V V
authors.initials: VV
authors.lastname: Romanenko
authors.forename: O S
authors.initials: OS
authors.lastname: Utnitskaia
authors.forename: T M
authors.initials: TM
authors.lastname: Motus
authors.forename: A V
authors.initials: AV
authors.lastname: Pereverzev
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D006801:Humans; D007115:Immunization Schedule; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D009017:Morbidity; D012426:Russia / Q000453:epidemiology; D013997:Time Factors; D014505:Urban Population; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines