title: Identification of Staphylococcus xylosus isolated from C57BL/6J-Nos2(tm1Lau) mice with dermatitis.
abstract: Coagulase negative staphylococci (CNS) are significant pathogens, particularly in medical device related infections and in immunocompromised patients. Five CNS strains were isolated from 5 NOS2 knockout mice with dermatitis. Histologically, granulomatous dermatitis was found in the skin around the ear with epidermal ulceration. Dermal lesions included pustules, necrosis, and accumulations of neutrophils and macrophages. Isolates of the bacterial strains were identified to be Staphylococcus xylosus by the API STAPH kit and 16S-23S intergenic transcribed spacer-PCR. These results demonstrate the potential of this organism to be an opportunistic pathogen in immunocompromised mice.
authors.affiliation: Department of Microbiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Korea.
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Won
authors.forename: Hyo Jung
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Goo Taeg
authors.initials: GT
authors.lastname: Oh
authors.forename: Bang Hyun
authors.initials: BH
authors.lastname: Kim
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Yong Ho
authors.initials: YH
authors.lastname: Park
authors.forename: Byung Hwa
authors.initials: BH
authors.lastname: Hyun
authors.forename: Yang Kyu
authors.initials: YK
authors.lastname: Choi
mesh_terms: D000818:Animals; D003030:Coagulase / Q000378:metabolism; D003872:Dermatitis / Q000382:microbiology* / Q000473:pathology; D006651:Histocytochemistry / Q000379:methods; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D009894:Opportunistic Infections / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000032:analysis; D012338:RNA, Ribosomal, 23S / Q000032:analysis; D013207:Staphylococcal Skin Infections / Q000382:microbiology* / Q000473:pathology; D013210:Staphylococcus / Q000145:classification / Q000302:isolation & purification*
chemical_list: D003030:Coagulase; D012336:RNA, Ribosomal, 16S; D012338:RNA, Ribosomal, 23S; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse