Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8.
We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.
Fujii
Nobuharu
N
Department of Internal Medicine (II), Okayama University Medical School, Okayama, Japan. nfujii@md.okayama-u.ac.jp
Ikeda
Kazuma
K
Takahashi
Naoto
N
Kojima
Kensuke
K
Kobayashi
Yoshimi
Y
Ashiba
Atsuko
A
Takenaka
Katsuto
K
Fukuda
Shunnichi
S
Shinagawa
Katsuji
K
Ishimaru
Fumihiko
F
Niiya
Kenji
K
Miura
Ikuo
I
Tanimoto
Mitsune
M
Harada
Mine
M
D000208:Acute Disease; D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics*; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D023981:Sarcoma, Myeloid / Q000235:genetics*; D014314:Trisomy / Q000235:genetics*