title: Stress-related modulation of matrix metalloproteinase expression.
abstract: Matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs), whose expression can be controlled by cytokines, play a role in extracellular matrix remodeling in physiological and pathological processes. Using a blister chamber wound model on UV-B-exposed human forearm skin, we examined whether stress or mood-associated neuroendocrine alteration is sufficient to modulate MMP and TIMP expression. We did not find evidence that depressive symptoms were reliably associated with modulation of either MMP or TIMP expression. However, we did find that activation of the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal medullary (SAM) axes can modulate levels of MMPs. A positive association between plasma norepinephrine levels and MMP-2 protein levels, and a negative correlation between plasma cortisol levels and MMP-2 levels were found. The data suggest that activation of the HPA and SAM axes, even in individuals within the normal range of depressive symptoms, could mediate MMP levels and wound healing in blister wounds.
authors.affiliation: Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, 2175 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Eric V
authors.initials: EV
authors.lastname: Yang
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bane
authors.forename: Robert C
authors.initials: RC
authors.lastname: MacCallum
authors.forename: Janice K
authors.initials: JK
authors.lastname: Kiecolt-Glaser
authors.forename: William B
authors.initials: WB
authors.lastname: Malarkey
authors.forename: Ronald
authors.initials: R
authors.lastname: Glaser
mesh_terms: D000313:Adrenal Medulla / Q000276:immunology / Q000378:metabolism; D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000276:immunology* / Q000378:metabolism* / Q000523:psychology; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology / Q000378:metabolism; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020784:Matrix Metalloproteinase 8 / Q000096:biosynthesis / Q000276:immunology / Q000528:radiation effects; D020782:Matrix Metalloproteinases / Q000096:biosynthesis* / Q000276:immunology / Q000528:radiation effects; D008875:Middle Aged; D015213:Neuroimmunomodulation / Q000276:immunology; D009490:Neurosecretory Systems / Q000276:immunology / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000276:immunology / Q000378:metabolism; D013312:Stress, Physiological / Q000276:immunology* / Q000378:metabolism* / Q000523:psychology; D013564:Sympathetic Nervous System / Q000276:immunology / Q000378:metabolism; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000096:biosynthesis / Q000276:immunology / Q000528:radiation effects; D019714:Tissue Inhibitor of Metalloproteinases / Q000096:biosynthesis* / Q000276:immunology / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D014945:Wound Healing / Q000276:immunology*
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020784:Matrix Metalloproteinase 8