title: Gadobenate dimeglumine-enhanced MR angiography of the abdominal aorta and renal arteries.
abstract: OBJECTIVE
  This study was conducted to determine the efficacy and safety of four different doses of gadobenate dimeglumine for contrast-enhanced three-dimensional MR angiography of the abdominal aorta and renal arteries.
  
  
  METHODS
  Ninety-four patients with suspected abnormality of the abdominal aorta or renal arteries underwent unenhanced three-dimensional gradient-recalled echo time-of-flight MR angiography and contrast-enhanced MR angiography after the IV injection of one of four doses of gadobenate dimeglumine (0.025, 0.05, 0.1, and 0.2 mmol/kg of body weight). Efficacy was assessed on-site and by two blinded off-site reviewers in terms of change in total diagnostic quality score and diagnostic quality score per vessel segment from baseline unenhanced time-of-flight MR angiography to contrast-enhanced MR angiography. Secondary efficacy end points included lesion count and level of confidence in lesion characterization. Safety assessments comprised adverse event monitoring, physical evaluation, vital signs, ECG, and laboratory investigations.
  
  
  RESULTS
  A significant change in the total diagnostic quality score from unenhanced to contrast-enhanced MR angiography was observed at all doses. The change increased with increased dose, plateauing at the 0.1 mmol/kg dose level. More patients with lesions detected and increased reviewer confidence for lesion characterization were noted on contrast-enhanced MR angiography compared with unenhanced MR angiography, although no dose-related trends were observed. All doses were well tolerated, and no significant changes in safety parameters were observed.
  
  
  CONCLUSIONS
  Gadobenate dimeglumine is an effective and safe agent for contrast-enhanced MR angiography of the abdominal aorta and renal arteries. A dose of 0.1 mmol/kg of body weight appears to be the most suitable.
authors.affiliation: Department of Radiology, Universitätsklinikum Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin, Schumannstr. 20/21, 10098 Berlin, Germany.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kroencke
authors.forename: Martin N
authors.initials: MN
authors.lastname: Wasser
authors.forename: Peter M T
authors.initials: PM
authors.lastname: Pattynama
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
authors.forename: Eckhardt
authors.initials: E
authors.lastname: Grabbe
authors.forename: Guy
authors.initials: G
authors.lastname: Marchal
authors.forename: Michael V
authors.initials: MV
authors.lastname: Knopp
authors.forename: Günther
authors.initials: G
authors.lastname: Schneider
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bonomo
authors.forename: Dudley J
authors.initials: DJ
authors.lastname: Pennell
authors.forename: Alessandro
authors.initials: A
authors.lastname: del Maschio
authors.forename: Hans-Rainer
authors.initials: HR
authors.lastname: Hentrich
authors.forename: Massimo
authors.initials: M
authors.lastname: Daprà
authors.forename: Miles A
authors.initials: MA
authors.lastname: Kirchin
authors.forename: Alberto
authors.initials: A
authors.lastname: Spinazzi
authors.forename: Matthias
authors.initials: M
authors.lastname: Taupitz
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
mesh_terms: D000328:Adult; D000368:Aged; D001012:Aorta, Abdominal / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D021621:Imaging, Three-Dimensional; D007275:Injections, Intravenous; D018810:Magnetic Resonance Angiography; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000009:adverse effects; D012077:Renal Artery / Q000473:pathology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium