title: A numerical method for renal models that represent tubules with abrupt changes in membrane properties.
abstract: The urine concentrating mechanism of mammals and birds depends on a counterflow configuration of thousands of nearly parallel tubules in the medulla of the kidney. Along the course of a renal tubule, cell type may change abruptly, resulting in abrupt changes in the physical characteristics and transmural transport properties of the tubule. A mathematical model that faithfully represents these abrupt changes will have jump discontinuities in model parameters. Without proper treatment, such discontinuities may cause unrealistic transmural fluxes and introduce suboptimal spatial convergence in the numerical solution to the model equations. In this study, we show how to treat discontinuous parameters in the context of a previously developed numerical method that is based on the semi-Lagrangian semi-implicit method and Newton's method. The numerical solutions have physically plausible fluxes at the discontinuities and the solutions converge at second order, as is appropriate for the method.
authors.affiliation: Department of Mathematics, University of North Carolina, Chapel Hill 27599, USA. layton@amath.unc.edu
authors.forename: Anita T
authors.initials: AT
authors.lastname: Layton
authors.forename: Harold E
authors.initials: HE
authors.lastname: Layton
mesh_terms: D000818:Animals; D001834:Body Water / Q000502:physiology; D007671:Kidney Concentrating Ability / Q000502:physiology*; D007685:Kidney Tubules, Collecting / Q000502:physiology*; D008566:Membranes / Q000502:physiology; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D009994:Osmolar Concentration