title: One-pot three-component reaction for the synthesis of alpha-(aminoethyl)-alpha,beta-enones.
abstract: [reaction: see text] The synthesis of alpha-substituted alpha,beta-enones by a new metal iodide-promoted one-pot three-component reaction involving commercially available cyclopropyl ketones, aldehydes, and secondary amines followed by base treatment is described.
authors.affiliation: Discovery Chemistry, ACADIA Pharmaceuticals A/S, Fabriksparken 58, DK-2600 Glostrup, Denmark.
authors.forename: Fabio
authors.initials: F
authors.lastname: Bertozzi
authors.forename: Magnus
authors.initials: M
authors.lastname: Gustafsson
authors.forename: Roger
authors.initials: R
authors.lastname: Olsson