title: Applications of a resorbable interbody spacer in posterior lumbar interbody fusion.
abstract: Polyhydroxy acids are a promising class of resorbable materials with potential applications in spinal surgery. One such polymer, MacroPore (MacroPore Biosurgery, Inc.), offers a balance of strength, predictable degradation, lack of stimulus of foreign body reaction, and biocompatibility with neural tissue. MacroPore can be formed into an array of shapes and can be manufactured, sterilized, and stored using conventional techniques. Limited clinical experience has been gained with resorbable implants used as load-sharing devices in a posterior lumbar interbody fusion construct.
authors.affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Alexander
authors.forename: Charles L
authors.initials: CL
authors.lastname: Branch
authors.forename: Brian R
authors.initials: BR
authors.lastname: Subach
authors.forename: Regis W
authors.initials: RW
authors.lastname: Haid
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000627:therapeutic use; D006801:Humans; D006880:Hydroxy Acids / Q000627:therapeutic use*; D019344:Lactic Acid / Q000627:therapeutic use; D008159:Lumbar Vertebrae / Q000187:drug effects* / Q000601:surgery*; D011091:Polyesters / Q000627:therapeutic use; D011108:Polymers / Q000627:therapeutic use; D013122:Spinal Diseases / Q000188:drug therapy* / Q000601:surgery*; D013123:Spinal Fusion
chemical_list: D001672:Biocompatible Materials; D006880:Hydroxy Acids; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)