The TNF-TNF receptor system.
Different forms of tumor necrosis factor (TNF) interact with two specific receptors for TNF (TNFR) on the cell membrane to induce a variety of effects. While sharing structural similarities in their extracellular domains, the two TNFRs differ in their intracellular domain, their signal transduction, and consequently their function. In addition, one of the two TNFRs can be expressed in two differently located isoforms. This makes the TNF-TNFR system very complex. The dual TNF function for either cell death or survival upon interaction of members of the TNF ligand family with members of the TNF receptor family will be discussed.
Hehlgans
Thomas
T
Department of Pathology/Tumor Immunology, University of Regensburg, D-93042 Regensburg, Germany.
Männel
Daniela N
DN
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D006801:Humans; D008024:Ligands; D008233:Lymphotoxin-alpha / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism*
D008024:Ligands; D008233:Lymphotoxin-alpha; D016328:NF-kappa B; D020033:Protein Isoforms; D018124:Receptors, Tumor Necrosis Factor; D011991:Receptors, Virus; D014409:Tumor Necrosis Factor-alpha