Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome.
We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with Zollinger-Ellison syndrome. There was extensive metastatic dissemination of the neuroendocrine component to regional lymph nodes and to the liver. The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed.
de Leval
Laurence
L
Department of Pathology, CHU of Liège, Sart-Tilman, 4000 Liège, Belgium. L.deLeval@ulg.ac.be
Hardy
Noëlle
N
Deprez
Manuel
M
Delwaide
Jean
J
Belaïche
Jacques
J
Boniver
Jacques
J
D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary*; D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000556:secondary*; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D009378:Neoplasms, Multiple Primary; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology*; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D010751:Phosphopyruvate Hydratase