title: Effects of methyllycaconitine and related analogues on bovine adrenal alpha3beta4* nicotinic acetylcholine receptors.
abstract: Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.
authors.affiliation: Division of Pharmacology, The Ohio State University, College of Pharmacy, Columbus, Ohio 43210, USA.
authors.forename: Darrell L
authors.initials: DL
authors.lastname: Bryant
authors.forename: R Benjamin
authors.initials: RB
authors.lastname: Free
authors.forename: Sara M
authors.initials: SM
authors.lastname: Thomasy
authors.forename: David J
authors.initials: DJ
authors.lastname: Lapinsky
authors.forename: K A
authors.initials: KA
authors.lastname: Ismail
authors.forename: K M
authors.initials: KM
authors.lastname: Arason
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Bergmeier
authors.forename: Dennis B
authors.initials: DB
authors.lastname: McKay
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D018733:Nicotinic Antagonists / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000378:metabolism*
chemical_list: D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; C403530:nicotinic receptor alpha3beta4; C054634:methyllycaconitine; D000157:Aconitine