Breast carcinoma: a report on the potential usage of the CC chemokine RANTES as a marker for a progressive disease.
BACKGROUND
High incidence and intensity of RANTES (CC chemokine) expression were noted in advanced breast carcinoma.


OBJECTIVE
To present two cases of breast carcinoma patients in whom RANTES expression was analyzed in parallel to disease progression.


RESULTS
Although no evidence of malignancy was detected in the axillary lymph nodes of the two patients, their disease progressed. The expression of RANTES in both patients was positive at diagnosis and predicted the clinical course.


CONCLUSIONS
These results, combined with our previous findings on the correlation between RANTES expression and advanced breast carcinoma, suggest that the assessment of RANTES expression may be useful for the identification of patients with apparently poor prognosis who may benefit from aggressive treatment. The above results call for large-scale studies by numerous research groups to determine the prognostic value of RANTES expression.
Wigler
Nely
N
Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Shina
Sima
S
Kaplan
Ofer
O
Luboshits
Galia
G
Chaitchik
Samario
S
Keydar
Iafa
I
Ben-Baruch
Adit
A
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000032:analysis* / Q000235:genetics; D019742:Chemokines, CC / Q000032:analysis* / Q000235:genetics; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D011379:Prognosis
D014408:Biomarkers, Tumor; D018946:Chemokine CCL5; D019742:Chemokines, CC