The TB structural genomics consortium: providing a structural foundation for drug discovery.
Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.
Goulding
Celia W
CW
Bioscience Division, Mail Stop M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Apostol
Marcin
M
Anderson
Daniel H
DH
Gill
Harindarpal S
HS
Smith
Clare V
CV
Kuo
Mack R
MR
Yang
Jin Kuk
JK
Waldo
Geoffrey S
GS
Suh
Se Won
SW
Chauhan
Radha
R
Kale
Avinash
A
Bachhawat
Nandita
N
Mande
Shekhar C
SC
Johnston
Jodie M
JM
Lott
J Shaun
JS
Baker
Edward N
EN
Arcus
Vickery L
VL
Leys
David
D
McLean
Kirsty J
KJ
Munro
Andrew W
AW
Berendzen
Joel
J
Sharma
Vivek
V
Park
Min S
MS
Eisenberg
David
D
Sacchettini
James
J
Alber
Tom
T
Rupp
Bernhard
B
Jacobs
William
W
Terwilliger
Thomas C
TC
D000217:Acyltransferases; D000446:Aldehyde-Lyases / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000737:chemistry*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D015195:Drug Design; D023281:Genomics; D005974:Glutamate-Ammonia Ligase / Q000737:chemistry; D008780:Methyltransferases / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000737:chemistry* / Q000187:drug effects*; D007296:Myo-Inositol-1-Phosphate Synthase / Q000737:chemistry; D010088:Oxidoreductases / Q000737:chemistry; D019704:Protein Disulfide-Isomerases / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; C085257:InhA protein, Mycobacterium; D008780:Methyltransferases; C019964:cyclopropane synthetase; D000217:Acyltransferases; C121433:antigen 85B, Mycobacterium tuberculosis; D000446:Aldehyde-Lyases; C020044:dihydroneopterin aldolase; D019704:Protein Disulfide-Isomerases; D007296:Myo-Inositol-1-Phosphate Synthase; D005974:Glutamate-Ammonia Ligase