title: [Controlled pathological study and preoperative MRI evaluation of the consistency of pituitary adenomas].
abstract: OBJECTIVE
  Consistency of pituitary adenoma may influence surgical remote of the tumor. Preoperative evaluation of tumor consistency will be useful in guiding the operative approach. This study was designed to investigate the relationship among pituitary adenoma consistency, collagen type I and MRI signal intensity.
  
  
  METHODS
  Twenty pituitary adenoma patients received transsphenoidal surgery. Preoperative MRI, H-E stains and collagen type I immunohistochemistry(IHC)-autonomic image analysis for tumor specimens were performed
  
  
  RESULTS
  Ten tumors were soft, mean T2WI tumor/while matter signal intensity ratio (TWSIR) is 17.38%; six were moderate, mean T2WI TWSIR was 2.01; and 4 were firm, mean T2WI TWSIR was 1.56. Mean collagen type I positive area ratio(CIPAR) of soft, moderate, and firm tumors was 17.38%, 27.30%, and 40.31%, respectively. Both C1PAR and T2WI TWSIR were significantly different among three types (P < 0.01) C1PAR was negatively correlated to T2WI TWSIR(P < 0.01).
  
  
  CONCLUSIONS
  Collagen type I content relates with the consistency of pituitary adenomas. MRI can predict of pituitary consistency adenoma; and those show hypointensity in T2WI are firm.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Sun Yat-sen University.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Hai-jun
authors.initials: HJ
authors.lastname: Wang
authors.forename: Ming-zhen
authors.initials: MZ
authors.lastname: Chen
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: He
authors.forename: Chun-long
authors.initials: CL
authors.lastname: Ke
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011300:Preoperative Care; D011859:Radiography
chemical_list: D024042:Collagen Type I