Cellular patterning of the vertebrate embryo.
Recent studies show that cell dispersal is a widespread phenomenon in the development of early vertebrate embryos. These cell movements coincide with major decisions for the spatial organization of the embryo, and they parallel genetic patterning events. For example, in the central nervous system, cell dispersal is first mainly anterior-posterior and subsequently dorsal-ventral. Thus, genes expressed in signaling centers of the embryo probably control cell movements, tightly linking cellular and genetic patterning. Cell dispersal might be important for the correct positioning of cells and tissues involved in intercellular signaling. The emergence of cell dispersal at the onset of vertebrate evolution indicates a shift from early, lineage-based cellular patterning in small embryos to late, movement-based cellular patterning of polyclones in large embryos. The conservation of the same basic body plan by invertebrate and vertebrate chordates suggests that evolution of the embryonic period preceding the phylotypic stage was by intercalary co-option of basic cell activities present in the ancestral metazoan cell.
Mathis
Luc
L
Unité de Biologie moléculaire du Développement, Institut Pasteur, 25, rue du Docteur Roux, 75724 Cédex 15, Paris, France.
Nicolas
Jean Francois
JF
D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning; D002465:Cell Movement; D004625:Embryo, Nonmammalian / Q000166:cytology*; D012249:Rhombencephalon / Q000196:embryology; D014561:Urochordata / Q000196:embryology; D014714:Vertebrates / Q000196:embryology*; D014981:Xenopus / Q000196:embryology