Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles.
Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and the uptake of free fatty acid in muscle. Previous studies using transgenic mice showed that increased LPL leads to myopathies, but these results were controversial. To examine this hypothesis, we studied LPL transgenic rabbits, and our results refute the suggested role of LPL in the pathogenesis of myopathies.
Koike
Tomonari
T
Cardiovascular Disease Laboratory, Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305-8575, Japan.
Wang
Xiaofei
X
Unoki
Hiroyuki
H
Liang
Jingyan
J
Ichikawa
Tomonaga
T
Kitajima
Shuji
S
Watanabe
Teruo
T
Fan
Jianglin
J
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006330:Heart Defects, Congenital / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000201:enzymology* / Q000235:genetics; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D015854:Up-Regulation / Q000235:genetics*
D012333:RNA, Messenger; D008071:Lipoprotein Lipase