title: Comparison of regularization techniques for the reconstruction of transmembrane potentials in the heart.
abstract: Computer simulations to reconstruct the transmembrane potential distribution were performed for an anisotropic finite element model of the heart. Transmembrane potential was reconstructed in the form of 3D patches. Test patterns generated with a cellular automaton were used. Tikhonov 0-order and 2-order reconstruction techniques were compared. Tikhonov 2-order regularization was shown to deliver better solutions; this is demonstrated by the inspection of the source space of the inverse problem and by the comparison of the correlation coefficients between the reconstructed and original distributions. Time information was incorporated into the regularization.
authors.affiliation: Institut of Biomedical Engineering, Universität Karlsruhe (TH), Germany. Oleg.Skipa@ibt.uni-karlsruhe.de
authors.forename: O
authors.initials: O
authors.lastname: Skipa
authors.forename: M
authors.initials: M
authors.lastname: Nalbach
authors.forename: F B
authors.initials: FB
authors.lastname: Sachse
authors.forename: O
authors.initials: O
authors.lastname: Dössel
mesh_terms: D018780:Body Surface Potential Mapping; D003196:Computer Graphics; D003198:Computer Simulation; D004562:Electrocardiography; D020342:Finite Element Analysis; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D008962:Models, Theoretical