title: A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men.
abstract: We conducted a prospective study on the association between supplemental vitamin E and colon cancer in 87,998 females from the Nurses' Health Study and 47, 344 males from the Health Professionals Follow-up Study. There was some suggestion that men with supplemental vitamin E intake of 300 IU/day or more may be at lower risk for colon cancer when compared with never users [multivariate relative risk (RR), 300-500 IU/day versus never users, 0.73 (95% confidence interval (CI), 0.52-1.03); >or=600 IU/day versus never users = 0.70 (95% CI = 0.38-1.29)], but CIs included 1. In women, there was no evidence for an inverse association between vitamin E supplementation and risk of colon cancer. Our findings do not provide consistent support for an inverse association between supplemental vitamin E and colon cancer risk. Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kana.wu@channing.harvard.edu
authors.forename: Kana
authors.initials: K
authors.lastname: Wu
authors.forename: Walter C
authors.initials: WC
authors.lastname: Willett
authors.forename: June M
authors.initials: JM
authors.lastname: Chan
authors.forename: Charles S
authors.initials: CS
authors.lastname: Fuchs
authors.forename: Graham A
authors.initials: GA
authors.lastname: Colditz
authors.forename: Eric B
authors.initials: EB
authors.lastname: Rimm
authors.forename: Edward L
authors.initials: EL
authors.lastname: Giovannucci
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage; D002338:Carotenoids / Q000008:administration & dosage; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000178:diet therapy* / Q000453:epidemiology*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D014807:Vitamin D; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid