title: Spatiotemporal specificity of synaptic plasticity: cellular rules and mechanisms.
abstract: Recent experimental results on spike-timing-dependent plasticity (STDP) and heterosynaptic interaction in various systems have revealed new temporal and spatial properties of activity-dependent synaptic plasticity. These results challenge the conventional understanding of Hebb's rule and raise intriguing questions regarding the fundamental processes of cellular signaling. In this article, I review these new findings that lead to formulation of a new set of cellular rules. Emphasis is on evaluating potential molecular and cellular mechanisms that may underlie the spike-timing window of STDP and different patterns of heterosynaptic modifications. I also highlight several unresolved issues, and suggest future lines of research.
authors.affiliation: Department of Neurobiology, University of Pittsburgh School of Medicine, 200 Lothrop St. E 1452 BST, Pittsburgh, PA 15261, USA. gqbi@pitt.edu
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Bi
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology; D013997:Time Factors
chemical_list: D002118:Calcium