title: Hepatitis C virus-host interactions: the NS5A protein and the interferon/chemokine systems.
abstract: The interactions that occur between viral proteins and host factors, such as cellular proteins and signal transduction machinery, have a significant influence on the replication, persistence, and pathogenesis of all viruses. This is exemplified by hepatitis C virus (HCV), which infects an estimated 3% of the world's population and is a significant cause of liver disease. HCV-host interactions also affect the outcome of interferon (IFN) antiviral therapy, which is effective only in certain patients. In this review, we focus on the HCV nonstructural 5A (NS5A) protein, a model for diverse virus-host interactions, and highlight the interaction of viruses, including HCV, with the chemokine system.
authors.affiliation: Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Khalid S A
authors.initials: KS
authors.lastname: Khabar
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Polyak
mesh_terms: D000998:Antiviral Agents / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D018925:Chemokines / Q000235:genetics / Q000378:metabolism*; D016174:Hepacivirus / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology*; D006526:Hepatitis C / Q000188:drug therapy / Q000821:virology; D006790:Host-Parasite Interactions; D006801:Humans; D007372:Interferons / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D016209:Interleukin-8 / Q000235:genetics / Q000378:metabolism; D008107:Liver Diseases / Q000150:complications; D015398:Signal Transduction; D017361:Viral Nonstructural Proteins / Q000502:physiology*; D014779:Virus Replication; D019892:eIF-2 Kinase / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000998:Antiviral Agents; D018925:Chemokines; D007372:Interferons; D016209:Interleukin-8; D017361:Viral Nonstructural Proteins; D019892:eIF-2 Kinase; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase