[Study of the influence of peroral zincacin on the removing of ingested Americium].
Effect of different cincacine doses was studied in rats ingesting americium citrate during 2 weeks. As a result new data showing the possibility and efficacy of per oral cincacine administration at americium intake into digestive tract have been obtained. Dose dependence of cincacine efficacy has been stated for per oral 241Am intake. Preparation administration at a dose of 25 mumol/kg reduces amount of 241Am in skeleton, liver and kidney by 93, 90 and 33%, respectively and is optimum for radionuclide removal from the body and for the prevention of its deposition in organs. Digestive system organs and kidney structure at cincacine administration at a dose of 150 and 300 mumol/kg) to the rats ingesting 241Am have been studied.
Zhorova
E S
ES
State Research Center-Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia. ibphgen@rcibph.dol.ru
Il'in
L A
LA
Ivannikov
A T
AT
Popov
B A
BA
Parfenova
I M
IM
D000284:Administration, Oral; D000576:Americium / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism; D006652:Histological Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D004369:Pentetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D002614:Chelating Agents; D004369:Pentetic Acid; D000576:Americium