[The toxicity of bilirubin to the central nervous system].
Whatever the causes of its accumulation, excessive production and/or insufficient elimination, unconjugated bilirubin when it reaches a certain concentration threshold, is responsible for neurones and astrocytes death. In this paper the mechanisms involved in this process of cellular death, from hemolysis to oxydation in neurons and neuroglial cells, are reviewed.
Vert
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Faculté de médecine de Nancy et service de néonatologie, maternité régionale de Nancy, BP 4213, 54042 Nancy.
Grojean
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S
D016923:Cell Death; D002490:Central Nervous System / Q000473:pathology; D002648:Child; D006461:Hemolysis; D006801:Humans; D007647:Kernicterus / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology; D010084:Oxidation-Reduction