Fluoro-A-85380 demonstrated no mutagenic properties in in vivo rat micronucleus and Ames tests.
The potential mutagenic properties (micronucleus and the Ames tests) of fluoro-A-85380 (2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine) were evaluated as a mandatory pre-clinical step. No statistically significant increase in the frequency of micronucleated polychromatic erythrocytes was found in animals treated at any dose tested. No biologically significant increase in the mean number of revertants was noted in all the Salmonella typhimurium strains tested with fluoro-A-85380. Therefore, fluoro-A-85380 demonstrated no mutagenic properties using these two tests.
Valette
Héric
H
Service Hospitalier Frédéric Joliot, CEA, DSV/DRM, 4 Place du Général Leclerc, F-91406, Orsay, France. valette@shfj.cea.fr
Dollé
Frédéric
F
Bottlaender
Michel
M
Hinnen
Françoise
F
Marzin
Daniel
D
D000818:Animals; D001384:Azetidines / Q000009:adverse effects*; D001854:Bone Marrow Cells; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004913:Erythrocytes, Abnormal / Q000187:drug effects / Q000473:pathology; D005260:Female; D008297:Male; D015162:Micronucleus Tests / Q000379:methods*; D016296:Mutagenesis / Q000187:drug effects*; D009152:Mutagenicity Tests / Q000379:methods*; D011725:Pyridines / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
C119803:2-fluoro-3-(2-azetidinylmethoxy)pyridine; D001384:Azetidines; D011725:Pyridines