title: A patient with paroxysmal nocturnal haemoglobinuria in whom granulocyte colony-stimulating factor administration resulted in improvement of recurrent enterocolitis and its associated haemolytic attacks.
abstract: We report an elderly patient with paroxysmal nocturnal haemoglobinuria (PNH), having recurrent enterocolitis and haemolytic attacks associated with cellular immunodeficiency. On admission, the patient had normal neutrophil count and function but a decreased T-cell count, decreased mitogenic reactions, and a negative tuberculin test. Granulocyte colony-stimulating factor (G-CSF) was administered, resulting in an increased T-cell count, normalization of T-cell function, increased blood levels of helper T cell (Th)1 and Th2 cytokines and improvement in the enterocolitis and haemolytic attacks. This suggests that G-CSF may be useful in the treatment of elderly PNH patients with cellular immunodeficiency.
authors.affiliation: 4th Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Fujimi
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Kogawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohnuma
authors.forename: Naoki
authors.initials: N
authors.lastname: Takahira
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Abe
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kitaoka
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kogawa
authors.forename: Ikuta
authors.initials: I
authors.lastname: Tanaka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Morii
authors.forename: Takeshi
authors.initials: T
authors.lastname: Terui
authors.forename: Sumio
authors.initials: S
authors.lastname: Sakamaki
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Maeda
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000368:Aged; D004760:Enterocolitis / Q000517:prevention & control*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006457:Hemoglobinuria, Paroxysmal / Q000188:drug therapy*; D006801:Humans; D008231:Lymphopenia / Q000188:drug therapy / Q000209:etiology; D055502:Secondary Prevention; D013601:T-Lymphocytes
chemical_list: D016179:Granulocyte Colony-Stimulating Factor