Oxidized lipoproteins and macrophages.
Macrophages are important participants in the development of atherosclerotic lesions, in cholesterol accumulation, as mediators of the immune response, and as sources of secreted enzymes and growth factors. Besides potentially contributing to local oxidation of lesion lipoproteins, many aspects of macrophage function can be affected by interaction with oxidized lipoproteins. Here we review macrophage responses to oxidized lipoproteins and provide novel data on the effects of a major oxidation product, 7-ketocholesterol, on high-density lipoprotein (HDL) function in cholesterol removal from macrophages.
Jessup
Wendy
W
Cell Biology Group, Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia. w.jessup@unsw.edu.au
Wilson
Paul
P
Gaus
Katharina
K
Kritharides
Len
L
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism; D006801:Humans; D007653:Ketocholesterols / Q000494:pharmacology; D008074:Lipoproteins / Q000502:physiology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008264:Macrophages / Q000502:physiology*; D010084:Oxidation-Reduction
D007653:Ketocholesterols; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D002784:Cholesterol; C003001:7-ketocholesterol