title: Change in generic and disease-specific health-related quality of life during a one-year period in patients with newly detected chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Although the health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD) has been assessed by generic or disease-specific HRQoL measures, the responsiveness of the generic HRQoL measures is generally weak.
  
  
  OBJECTIVE
  To investigate the responses generated by generic and disease-specific HRQoL questionnaires, we prospectively followed the clinical course of patients with newly detected COPD after the initiation of treatment.
  
  
  METHODS
  A prospective, longitudinal study with a 1-year follow-up was designed. The forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC), the Nottingham Health Profile (NHP) as a generic HRQoL measure, and the Chronic Respiratory Disease Questionnaire (CRQ) as a disease-specific HRQoL measure were measured at baseline and at 3, 6, and 12 months after the initiation of standard treatment.
  
  
  RESULTS
  Eighty-two patients completed the study. The FEV(1), FVC, and NHP and CRQ scores improved significantly during the first 3 months (p < 0.05). During the last 6 months, although the FEV(1) declined (p < 0.05), the HRQoL assessed by the NHP and CRQ remained elevated. Except for the score on the social isolation section of the NHP at 12 months, all HRQoL scores at 6 and 12 months were significantly improved compared to baseline (p < 0.05).
  
  
  CONCLUSIONS
  In new patients with COPD, the NHP as well as the CRQ was able to detect changes in the HRQoL associated with effective medical interventions. The influence of the changes in airflow limitation on the HRQoL was weak.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. tsukino@kuhp.kyoto-u.ac.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tsukino
authors.forename: Koichi
authors.initials: K
authors.lastname: Nishimura
authors.forename: Stephen P
authors.initials: SP
authors.lastname: McKenna
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ikeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Hajiro
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Takateru
authors.initials: T
authors.lastname: Izumi
mesh_terms: D000368:Aged; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D011788:Quality of Life; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires