title: Response to exercise of patients with idiopathic hyper-CK-emia.
abstract: Patients with an idiopathic increase in serum creatine kinase (CK) levels (hyper-CK-emia) have a benign prognosis, but symptoms may be disabling in daily life. Previous studies have suggested that physical exercise increases the severity of complaints in these patients. We studied whether maximal and submaximal bouts of exercise on a cycle ergometer are harmful for patients with idiopathic hyper-CK-emia. Such dynamic exercise did not lead to larger increases in serum CK activity or more complaints in 11 patients with idiopathic hyper-CK-emia, compared with 11 age-matched healthy controls. Our data suggest that exercise does not result in more extensive muscle damage in patients with idiopathic hyper-CK-emia than in healthy subjects.
authors.affiliation: Department of Neurology, University Medical Center, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. J.Reijneveld@neuro.azu.nl
authors.forename: J C
authors.initials: JC
authors.lastname: Reijneveld
authors.forename: B C M
authors.initials: BC
authors.lastname: Te Boekhorst
authors.forename: M L
authors.initials: ML
authors.lastname: Zonderland
authors.forename: S
authors.initials: S
authors.lastname: Kalmijn
authors.forename: N C
authors.initials: NC
authors.lastname: Notermans
mesh_terms: D000293:Adolescent; D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D017079:Exercise Tolerance / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000503:physiopathology*; D009468:Neuromuscular Diseases / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology*; D010146:Pain / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology; D010809:Physical Fitness / Q000502:physiology*; D011795:Surveys and Questionnaires; D015854:Up-Regulation / Q000502:physiology*
chemical_list: D003402:Creatine Kinase