title: [Rhodiola rosea extract for prophylaxis of ischemic cerebral circulation disorder].
abstract: It was experimentally established that prophylactic introduction of a Rhodiola Rosea extract prevents the ischemic brain damage development. A course administration of the drug in a dose of 700 mg/kg arrests the development of hyper- and hypoperfusion in cerebral circulation, weakens the postischemic hyperglycemic reaction, lowers oxygen extraction by cerebral tissues, suppresses lactate acidosis, promotes pyruvate participation in metabolic processes inhibits edema swelling, prevents the "calcium paradox" development, and decreases manifestations of the lipid peroxidation processes.
authors.affiliation: Pharmacology Department, State Pharmaceutical Academy, Pyatigorsk, pr. Kalinina 11, 357532 Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Pogorelyĭ
authors.forename: L M
authors.initials: LM
authors.lastname: Makarova
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D001929:Brain Edema / Q000517:prevention & control*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002374:Catalase / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D002374:Catalase