title: Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil.
abstract: BACKGROUND
  Diacylglycerol is a natural component of edible oils that has metabolic characteristics that are distinct from those of triacylglycerol.
  
  
  OBJECTIVE
  We assessed the efficacy of an oil containing mainly 1,3-diacylglycerol in reducing body weight and fat mass when incorporated into a reduced-energy diet.
  
  
  METHODS
  The study was a randomized, double-blind, parallel intervention trial that was conducted at an outpatient clinical research center. The subjects (n = 131) were overweight or obese men (waist circumference > or = 90 cm) and women (waist circumference > or = 87 cm). Food products (muffins, crackers, soup, cookies, and granola bars) containing diacylglycerol or triacylglycerol oil and having the same fatty acid composition were incorporated into a reduced-energy diet (2100-3350-kJ/d deficit) for 24 wk. Percentages of change in body weight, fat mass, and intraabdominal fat area were assessed.
  
  
  RESULTS
  In an intention-to-treat analysis, body weight and fat mass decreased significantly more in the diacylglycerol group than in the triacylglycerol group (P = 0.025 and 0.037, respectively). By the end of the trial, mean body weight had decreased 3.6% and 2.5% in the diacylglycerol and triacylglycerol groups, respectively. Fat mass decreased 8.3% and 5.6% in the diacylglycerol and triacylglycerol groups, respectively.
  
  
  CONCLUSIONS
  Foods containing diacylglycerol oil promoted weight loss and body fat reduction and may be useful as an adjunct to diet therapy in the management of obesity.
authors.affiliation: Chicago Center for Clinical Research, Chicago, IL 60610, USA. kmaki@protocare.com
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Maki
authors.forename: Michael H
authors.initials: MH
authors.lastname: Davidson
authors.forename: Rikio
authors.initials: R
authors.lastname: Tsushima
authors.forename: Noboru
authors.initials: N
authors.lastname: Matsuo
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tokimitsu
authors.forename: Denise M
authors.initials: DM
authors.lastname: Umporowicz
authors.forename: Mary R
authors.initials: MR
authors.lastname: Dicklin
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Foster
authors.forename: Kate A
authors.initials: KA
authors.lastname: Ingram
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Anderson
authors.forename: Scott D
authors.initials: SD
authors.lastname: Frost
authors.forename: Marjorie
authors.initials: M
authors.lastname: Bell
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D001823:Body Composition; D001824:Body Constitution; D004032:Diet; D004038:Diet, Reducing; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000009:adverse effects; D004075:Diglycerides / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D002149:Energy Intake; D015444:Exercise; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy; D014280:Triglycerides / Q000008:administration & dosage*; D015431:Weight Loss
chemical_list: D004042:Dietary Fats, Unsaturated; D004075:Diglycerides; D008055:Lipids; D014280:Triglycerides