title: Cytotoxic diarylheptanoids from the roots of Juglans mandshurica.
abstract: A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (2-5) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC(50)'s ranging from 2 to 25 microg/mL.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.
authors.forename: Kyung-Seon
authors.initials: KS
authors.lastname: Lee
authors.forename: Gao
authors.initials: G
authors.lastname: Li
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Chong-Soon
authors.initials: CS
authors.lastname: Lee
authors.forename: Mi-Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Yurng-Dong
authors.initials: YD
authors.lastname: Jhang
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D031324:Juglans / Q000737:chemistry*; D007723:Korea; D008175:Lung Neoplasms; D008519:Medicine, Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D012717:Sesquiterpenes