[Circadian features of carcinogenesis of the large intestine induced by 1,2-dimethylhydrazine in rats].
The study was concerned with comparison of carcinogenesis induced in the rat large intestine by 5 single doses of 1,2-dimethylhydrazine (DMH) 21 mg/kg injected at different circadian stages--either at 10 a.m. or 10 p.m. Evening injections were followed by significant decrease in incidence (from 91 to 75%) and size of tumor (27.2-15.5 mm2). Also, there were relatively fewer large tumors in the evening series.
Dubina
M V
MV
I.P. Pavlov State Medical University.
Petrishev
N N
NN
Panchebko
A V
AV
Fedorov
E S
ES
Anisimov
V N
VN
D019813:1,2-Dimethylhydrazine / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002940:Circadian Rhythm; D003110:Colonic Neoplasms / Q000139:chemically induced*; D003627:Data Interpretation, Statistical; D008297:Male; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D002273:Carcinogens; D019813:1,2-Dimethylhydrazine