title: Hyperhomocysteinaemia in Sri Lankan patients with coronary artery disease.
abstract: OBJECTIVE
  To determine the association between hyperhomocysteinaemia and coronary artery disease (CAD) in a sample of Sri Lankans.
  
  
  METHODS
  A case control study.
  
  
  METHODS
  Asiri Hospital, Kirula Road, Colombo 5, Sri Lanka.
  
  
  METHODS
  105 patients with coronary artery disease and 112 controls.
  
  
  METHODS
  Fasting serum homocysteine levels were measured in 105 patients diagnosed as having CAD and in 112 unmatched controls. All patients admitted with clinical, electrocardiographical, biochemical or echocardiographical evidence of CAD were included in the study. Controls were selected from subjects admitted for health screening.
  
  
  RESULTS
  105 patients with CAD and 112 controls (unmatched for age and sex) were studied. A serum homocysteine level in excess of 18.2 mumol/l was considered high. Confounding effects of other conventional risk factors for CAD were controlled using multivariate logical regression analysis.
  
  
  CONCLUSIONS
  Hyperhomocysteinaemia is significantly associated with CAD. Multivariate logistic regression analysis indicated that the association between hyperhomocysteinaemia and CAD was confounded by other risk factors. However, statistical analysis revealed a significant independent association between hyperhomocysteinaemia and CAD (adjusted odds ratio = 2.881).
authors.affiliation: Asiri Hospital, Colombo. sriy@dynaweb.lk
authors.forename: Sriyantha
authors.initials: S
authors.lastname: Mendis
authors.forename: Pramod
authors.initials: P
authors.lastname: Ranatunga
authors.forename: Mohan
authors.initials: M
authors.lastname: Jayatilake
authors.forename: Sanjeewa
authors.initials: S
authors.lastname: Wanninayake
authors.forename: Rajitha
authors.initials: R
authors.lastname: Wickremasinghe
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D013188:Sri Lanka / Q000453:epidemiology