title: Regulation of signal transduction pathways in development by glycosylation.
abstract: Recent studies from several laboratories have provided evidence that cell surface complex carbohydrates play key roles in the regulation of developmentally relevant signal transduction events. The demonstration that Fringe, a known modifier of Notch function, is a fucose-specific N-acetylglucosaminyltransferase provided strong evidence that the Notch signaling pathway could be regulated by alterations of O-fucose structures. More recently, the demonstration that O-fucose modification of Cripto is essential for Nodal-dependent signaling provides further evidence of a role for glycosylation in signal transduction. These and other examples provide a new paradigm for the regulation of signal transduction events by glycosylation.
authors.affiliation: Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794-5215, USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Haltiwanger
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002462:Cell Membrane / Q000502:physiology*; D029721:Drosophila Proteins / Q000502:physiology; D005643:Fucose / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases / Q000502:physiology; D009844:Oligosaccharides / Q000737:chemistry; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; D006023:Glycoproteins; D008565:Membrane Proteins; D009844:Oligosaccharides; D051880:Receptors, Notch; D005643:Fucose; D017351:N-Acetylglucosaminyltransferases; C090576:fng protein, Drosophila