[The effects of tablet tongmaijiangzhi on hyperlipidemia and nitric oxide of patients with non-insulin-dependent diabetes mellitus].
OBJECTIVE
To investigate the effects of Tablet Tongmaijiangzhi on hyperlipidemia and nitric oxide of patients with non-insulin-dependent diabetes mellitus.


METHODS
65 patients were randomly divided into Tablet Tongmaijiangzhi(TTMJZ) group(33 patients) and Zocor group(32 patients), treated with TTMJZ 4 tab, tid. and Zocor 5 mg, qd. respectively for 8 weeks.


RESULTS
Serum levels of TC, LDL, ApoB were markedly decreased in both groups after treatments (P < 0.01). Non-significant difference was found between these two groups (P > 0.05). But after treatment the serum levels of TG were decreased and the serum levels of HDL, ApoA1 were increased significantly in TTMJZ group than in Zocor group (P < 0.05). Furthermore, the serum level of nitric oxide(NO) was increased and the blood viscosity was decreased significantly after treated with TTMJZ (P < 0.05 or P < 0.01).


CONCLUSIONS
Tablet Tongmaijiangzhi has the advantage of Zocor in lipids regulating effects on patients with non-insulin-dependent diabetes mellitus and hyperlipidemia. TTMJZ can also decrease blood viscosity and increase NO to protect vascular endothelium.
Wu
Guozhen
G
The First Affiliated Hospital of Zhongsan University, Guangzhou 510080.
Liu
Hongjian
H
Ye
Xin
X
Zhu
Yayi
Y
D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D001809:Blood Viscosity / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D008517:Phytotherapy; D019821:Simvastatin / Q000008:administration & dosage / Q000627:therapeutic use; D013607:Tablets; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; D013607:Tablets; D014280:Triglycerides; D009569:Nitric Oxide; D019821:Simvastatin