title: Serotonin modulates neuromuscular transmission in frogs.
abstract: The effect of 5-hydroxytryptamine (serotonin) on neuromuscular transmission in frog skeletal muscle was studied using voltage clamp technique. Serotonin produced no effect on end-plate currents during low frequency electrical stimulation of the motor nerve, but increased the amplitude depression of multiquantal currents during high-frequency stimulation similar to motor commands fired by motoneurons. It was shown that the inhibitory effect of serotonin on neuromuscular transmission is determined by slow potential-dependent block of open ionic channels in the postsynaptic membrane accumulating during rhythmic activation of the synapse.
authors.affiliation: Kazan State Medical University. ask@ksu.ru
authors.forename: N K
authors.initials: NK
authors.lastname: Khabibullina
authors.forename: A V
authors.initials: AV
authors.lastname: Shakirzyanova
authors.forename: A I
authors.initials: AI
authors.lastname: Skorinkin
authors.forename: R A
authors.initials: RA
authors.lastname: Afzalov
authors.forename: R A
authors.initials: RA
authors.lastname: Giniatullin
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000494:pharmacology; D000818:Animals; D004594:Electrophysiology; D007477:Ions; D008564:Membrane Potentials; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009388:Neostigmine / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D011898:Ranidae; D012584:Sciatic Nerve / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D007477:Ions; D012701:Serotonin; D009388:Neostigmine; D000110:Acetylcholinesterase; D000109:Acetylcholine