Active immunization with a glycolipid transition state analogue protects against endotoxic shock.
Jones
Lyn H
LH
Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Altobell
Laurence J
LJ
MacDonald
Mary T
MT
Boyle
Nicholas A
NA
Wentworth
Paul
P
Lerner
Richard A
RA
Janda
Kim D
KD
D000818:Animals; D000906:Antibodies / Q000097:blood; D004164:Diphosphonates / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology / Q000472:pathogenicity; D006001:Glycoconjugates / Q000737:chemistry / Q000276:immunology*; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology*; D006433:Hemocyanins / Q000737:chemistry / Q000276:immunology*; D008050:Lipid A / Q000276:immunology / Q000633:toxicity; D051379:Mice; D018716:Molecular Mimicry; D012772:Shock, Septic / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology
D000906:Antibodies; D004164:Diphosphonates; D006001:Glycoconjugates; D006017:Glycolipids; D008050:Lipid A; D014409:Tumor Necrosis Factor-alpha; D014614:Vaccines, Synthetic; C044283:lipid X; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin