title: Myosin VI, an actin motor for membrane traffic and cell migration.
abstract: The actin cytoskeleton and associated myosin motor proteins are essential for the transport and steady-state localization of vesicles and organelles and for the dynamic remodeling of the plasma membrane as well as for the maintenance of differentiated cell-surface structures. Myosin VI may be expected to have unique cellular functions, because it moves, unlike almost all other myosins, towards the minus end of actin filaments. Localization and functional studies indicate that myosin VI plays a role in a variety of different intracellular processes, such as endocytosis and secretion as well as cell migration. These diverse functions of myosin VI are mediated by interaction with a range of different binding partners.
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK. fb1@mole.bio.cam.ac.uk
authors.forename: Folma
authors.initials: F
authors.lastname: Buss
authors.forename: J Paul
authors.initials: JP
authors.lastname: Luzio
authors.forename: John
authors.initials: J
authors.lastname: Kendrick-Jones
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D004705:Endocytosis; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D018995:Myosin Heavy Chains / Q000737:chemistry* / Q000502:physiology*; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D000199:Actins; C089785:myosin VI; D018995:Myosin Heavy Chains