Polyphenols from the heartwood of Cercidiphyllum japonicum and their effects on proliferation of mouse hair epithelial cells.
The methanol extract of heartwood of Cercidiphyllum japonicum (Cercidiphyllaceae) stimulated proliferation of mouse hair epithelial cells, similar to minoxidil and procyanidin B-2. (+)-Taxifolin ( 2), quercetin ( 3), myricetin ( 4), (+)-dihydromyricetin ( 5) and gallic acid ( 6) were isolated from C. japonicum and showed significant proliferative activities on the hair epithelial cells.
Towatari
Keisuke
K
Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Yoshida
Kiyo
K
Mori
Nobuhiro
N
Shimizu
Kuniyoshi
K
Kondo
Ryuichiro
R
Sakai
Kokki
K
D000818:Animals; D044946:Biflavonoids; D002392:Catechin / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects; D005419:Flavonoids; D006197:Hair / Q000166:cytology* / Q000187:drug effects*; D051379:Mice; D008914:Minoxidil / Q000494:pharmacology; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D044945:Proanthocyanidins; D031995:Saxifragaceae; D013936:Thymidine / Q000378:metabolism
D044946:Biflavonoids; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D044945:Proanthocyanidins; C479578:procyanidin B; C017674:procyanidin; D008914:Minoxidil; D002392:Catechin; D013936:Thymidine