Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature.
The authors report an exceedingly rare case of a patient harboring a primary, spinal, C1-2, intradural, extramedullary meningeal sarcoma in which there were glial fibrillary acidic protein-immunoreactive components, but, importantly, no physical connection with neural tissue. On initial diagnostic imaging, neuroradiological features suggestive of a spinal meningioma were demonstrated in this 73-year-old man. He underwent a C1-2 laminectomy and removal of the posterior ring of the foramen magnum, and the lesion was excised. Histological and immunohistochemical testing showed a gliosarcoma. The clinical, radiological, and operative data are reviewed, as are the histopathological findings. To the authors' knowledge, this is the first case of a primary spinal intradural extramedullary gliosarcoma reported in the literature.
Barbagallo
Giuseppe M V
GM
Institutes of Neurosurgery and Pathological Anatomy, University of Catania, Catania, Italy. giuseppebarbagal@hotmail.com
Lanzafame
Salvatore
S
Nicol
etti Giovanni F
eG
Platania
Nunzio
N
Albanese
Vincenzo
V
D000368:Aged; D002574:Cervical Vertebrae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D018316:Gliosarcoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery
D005904:Glial Fibrillary Acidic Protein