Endophenazines A-D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus. I. Taxonomy, fermentation, isolation and biological activities.
Four new members of the phenazine family, endophenazines A-D, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).
Gebhardt
Klaus
K
Schimana
Judith
J
Krastel
Philipp
P
Dettner
Konrad
K
Rheinheimer
Joachim
J
Zeeck
Axel
A
Fiedler
Hans-Peter
HP
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001181:Arthropods / Q000382:microbiology*; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D010619:Phenazines / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism; D013559:Symbiosis
D000900:Anti-Bacterial Agents; D010619:Phenazines; C469530:endophenazine A; C469531:endophenazine B; C469532:endophenazine C; C469529:endophenazine D