Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with Free radical scavenging activity from Aspergillus niger CFR-W-105.
An enzyme inhibitor, nigerloxin, with inhibition against soy bean lipoxygenase-I (LOX-1), rat lens aldose reductase (RLAR) as well as free radical scavenging activity was isolated from the fermented wheat bran using Aspergillus niger CFR-W-105. Its chemical structure was identified as 2-amido-3-hydroxy-6-methoxy-5-methyl-4-(prop-1'-enyl) benzoic acid by NMR and GCEIMS data. The IC50 values against LOX-1 and RLAR were found to be 79 microM and 69 microM and ED50 against 1,1-diphenyl-2-picrylhydrazyl (DPPH) was 66 microM.
Rao
K C Sekhar
KC
Fermentation Technology and Bioengineering Department, Central Food Technological Research Institute, Mysore 570 013, India.
Divakar
S
S
Babu
K Naveen
KN
Rao
A G Appu
AG
Karanth
N G
NG
Sattur
A P
AP
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001234:Aspergillus niger / Q000378:metabolism*; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification*; D008084:Lipoxygenase / Q000187:drug effects; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D011407:Propane / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification*; D051381:Rats
D001565:Benzoates; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; C469528:nigerloxin; D000449:Aldehyde Reductase; D008084:Lipoxygenase; D011407:Propane