title: Factor XIII replacement in stem-cell transplant recipients with severe hemorrhagic cystitis: a report of four cases.
abstract: BACKGROUND
  Hemorrhagic cystitis (HC) is an important cause of morbidity in patients undergoing allogeneic stem-cell transplantation (SCT). Various causes have been identified, such as the use of high-dose cyclophosphamide or busulfan and the occurrence of acute graft-versus-host disease or viral infections (cytomegalovirus, adenovirus, polyomavirus).
  
  
  METHODS
  The clinical course of four patients treated with factor XIII (FXIII) concentrate for severe HC after allogeneic SCT is described.
  
  
  RESULTS
  Four patients were treated with one or two infusions of 50 IU/kg of FXIII concentrate. Only one patient showed a plasmatic FXIII decrease before treatment. Three of the four patients responded to this treatment, and HC completely resolved in two of them. No adverse event was observed.
  
  
  CONCLUSIONS
  The use of FXIII concentrate can improve the major symptoms of HC in patients with decreased or normal FXIII plasma level after allogeneic SCT.
authors.affiliation: Department of Pharmacy, Besançon University Hospital, Boulevard Fleming, 25030 Besançon Cedex, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Demesmay
authors.forename: Edgar
authors.initials: E
authors.lastname: Tissot
authors.forename: Claude-Eric
authors.initials: CE
authors.lastname: Bulabois
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Bertrand
authors.forename: Evelyne
authors.initials: E
authors.lastname: Racadot
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Woronoff-Lemsi
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Cahn
authors.forename: Eric
authors.initials: E
authors.lastname: Deconinck
mesh_terms: D000328:Adult; D003556:Cystitis / Q000150:complications*; D005176:Factor XIII / Q000008:administration & dosage*; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
chemical_list: D005176:Factor XIII