title: [Immunological subtypes of childhood T-cell acute lymphoblastic leukemia and their prognostic significance].
abstract: The data on examination and treatment of 39 children with T-cell acute lymphoblastic leukemia (T-ALL) were assessed; all patients received ALL BFM-90-M treatment. The fraction of children with T-ALL among ALL patients in Belarus was 12.2% (pre-T-ALL--15, cortical T-ALL--46 and mature T-ALL--23%). Also, a subtype of T-ALL with atypical expression of markers was identified (13%). Overall 7-year survival in T-ALL patients was 47(20%). The worst prognosis was recorded in the T-ALL subgroup with atypical expression of markers (p < 0.001 as compared with the other subgroups). As for outcome--from best to worst, T-ALL subtypes ranged as follows: cortical T-ALL, mature T-ALL, pre-T-ALL and T-ALL with atypical expression of markers.
authors.affiliation: Republican Center for Pediatric Oncology and Hematology Research, Minsk, Belarus.
authors.forename: I V
authors.initials: IV
authors.lastname: Proleskovskaia
authors.forename: S E
authors.initials: SE
authors.lastname: Buglova
authors.forename: O V
authors.initials: OV
authors.lastname: Aleĭnikova
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D006651:Histocytochemistry; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000145:classification* / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D015415:Biomarkers