title: Mycoplasma hominis and Ureaplasma species brain abscess in a neonate.
abstract: We report an infant with a mixed Mycoplasma and Ureaplasma brain abscess who was successfully treated with intravenous doxycycline and erythromycin. Therapeutic concentrations of doxycycline were demonstrated in cerebrospinal fluid. This report is evidence of the potential for Mycoplasma and Ureaplasma to produce focal central nervous system infection, as well as meningitis, in neonates and that use of doxycycline can be efficacious in the therapy of such infections.
authors.affiliation: Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, USA.
authors.forename: Rohit P
authors.initials: RP
authors.lastname: Rao
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Ghanayem
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Kaufman
authors.forename: K Sue
authors.initials: KS
authors.lastname: Kehl
authors.forename: David C
authors.initials: DC
authors.lastname: Gregg
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Chusid
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D009175:Mycoplasma Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D019535:Mycoplasma hominis / Q000302:isolation & purification*; D014509:Ureaplasma / Q000302:isolation & purification*; D016869:Ureaplasma Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline