Suppression of experimental autoimmune uveoretinitis by anti-alphabeta TCR monoclonal antibody.
OBJECTIVE
To evaluate the effects of anti-alphabeta T cell receptor monoclonal antibody (R73) on the induction of experimental autoimmune uveoretinitis (EAU) in rats.


METHODS
Lewis rats in which EAU was induced were treated with R73. All rats were examined for the clinical course of EAU, pathological findings of the globe, delayed-type hypersensitivity, and the interleukin-2 (IL-2) gene and protein expression in the eye.


RESULTS
The R73 treatment was effective for delaying EAU onset, decreasing the severity of EAU, and suppressing delayed-type hypersensitivity to the antigen. IL-2 gene and protein expression was reduced by R73 treatment in the anterior and posterior segments of the eye.


CONCLUSIONS
R73 treatment is effective for suppression of the development of EAU, inhibiting IL-2 expression in the eye.
Inoki
Taeko
T
Department of Ophthalmology, Jichi Medical School, Tochigi, Japan.
Yamagami
Satoru
S
Sakai
Rieko
R
Isobe
Mitsuaki
M
Tsuru
Tadahiko
T
Kawashima
Hidetoshi
H
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000378:metabolism; D019393:Arrestin / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D002829:Choroid / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007150:Immunohistochemistry; D007376:Interleukin-2 / Q000235:genetics / Q000378:metabolism; D007498:Iris / Q000503:physiopathology; D009994:Osmolar Concentration; D051381:Rats; D011917:Rats, Inbred Lew; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D012160:Retina / Q000503:physiopathology; D012173:Retinitis / Q000188:drug therapy* / Q000276:immunology; D014158:Transcription, Genetic; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology
D000911:Antibodies, Monoclonal; D019393:Arrestin; D007376:Interleukin-2; D016693:Receptors, Antigen, T-Cell, alpha-beta