title: [Magnetic resonance imaging manifestation of 500 patients with primary hepatic cell carcinoma].
abstract: OBJECTIVE
  Magnetic resonance imaging (MRI) is one of the main imaging diagnostic methods for primary hepatic cell carcinoma. This study was designed to summarize the MRI manifestation and to evaluate Gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) and super paramagnetic iron oxide particles(SPIO) enhanced MRI in diagnosis of small hepatic carcinoma.
  
  
  METHODS
  Five hundreds patients diagnosed as primary hepatic cell carcinoma histologically were examined by MRI plain scan, plain scan + Gd-DTPA enhanced T1 weighted imaging, and plain scan + Gd-DTPA T1 weighted imaging + SPIO-enhanced heavy T2 weighted imaging was performed, respectively.
  
  
  RESULTS
  In 500 patients, there were 65 (13.0%) small hepatic cell carcinoma, 81(16.2%) nodular lesions, 325 (65.0%) lump lesions; 29(5.8%) diffused lesions. 310(62%) patients were single lesion and the rest were multiple lesions. Twelve percent of the cases was associated with lymph nodes metastases, and 31.4% were complicated with vascular invasion. Diameter of the lesion was correlated positively to intro-hepatic metastases of the same or different lobe, the lymph nodes metastases and vascular invasion (P < 0.05). Totally 71 lesions were detected in the 65 cases with small hepatic carcinoma. Enhanced scan detected more lesions than plain scan (P < 0.05), and the lesions detected by Gd-DTPA + SPIO-enhanced scan were more than that by Gd-DTPA alone (P < 0.05).
  
  
  CONCLUSIONS
  With the diameter of the lesion increase, the possibility of intro-hepatic metastases, lymph node metastases, and vascular invasion increased. For the MRI diagnosis of small HCC, enhanced scan especially Gd-DTPA + SPIO enhanced scan could detect more lesions than plain scan.
authors.affiliation: Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P. R. China. sy13922704708@163.net
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Bi-ling
authors.initials: BL
authors.lastname: Liang
authors.forename: Xue-hui
authors.initials: XH
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
authors.forename: Bang-kun
authors.initials: BK
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography
chemical_list: D019786:Gadolinium DTPA