title: Distribution of PCBs and organochlorine pesticides in umbilical cord and maternal serum.
abstract: Polychlorinated biphenyls (PCBs) and organochlorine pesticides, such as hexachlorobenzene (HCB) and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE) are compounds widespread in the environment, highly lipophilic, and accumulate in biological systems. The newborn are exposed to these organochlorine compounds across the placenta and through breastfeeding. This study reports the levels of selected PCB congeners, p,p'-DDE and HCB in maternal blood and cord blood samples collected at delivery between November and December 1999 from 44 women living in the urban area of Antwerp, Belgium. Results show that all newborns contained detectable levels of PCBs, p,p'-DDE and HCB. The median concentration of PCBs was 450 pg/ml and ranged between 120 and 1580 pg/ml, while the median concentrations of HCB and p,p'-DDE were 70 and 490 pg/ml, respectively. Concentrations of PCBs and p,p'-DDE in cord blood (ng/ml) were positively associated with concentrations in maternal blood (ng/ml) (coefficients=0.74 and 0.92, P<0.05). We conclude that all investigated organochlorine compounds have an efficient transplacental transfer.
authors.affiliation: Toxicological Centre, University of Antwerp, Wilrijk, Belgium. covaci@uia.ua.ac.be
authors.forename: A
authors.initials: A
authors.lastname: Covaci
authors.forename: Ph
authors.initials: P
authors.lastname: Jorens
authors.forename: Y
authors.initials: Y
authors.lastname: Jacquemyn
authors.forename: P
authors.initials: P
authors.lastname: Schepens
mesh_terms: D000328:Adult; D001530:Belgium; D001942:Breast Feeding; D004785:Environmental Pollutants / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007306:Insecticides / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange; D010920:Placenta; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D011247:Pregnancy; D014505:Urban Population
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D011078:Polychlorinated Biphenyls