Cytotoxic diarylheptanoids from the roots of Juglans mandshurica.
A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (2-5) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC(50)'s ranging from 2 to 25 microg/mL.
Lee
Kyung-Seon
KS
College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.
Li
Gao
G
Kim
Sung Hwan
SH
Lee
Chong-Soon
CS
Woo
Mi-Hee
MH
Lee
Seung-Ho
SH
Jhang
Yurng-Dong
YD
Son
Jong-Keun
JK
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D031324:Juglans / Q000737:chemistry*; D007723:Korea; D008175:Lung Neoplasms; D008519:Medicine, Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D012717:Sesquiterpenes