New terpenoids from the brown alga Stypopodium zonale.
Three new terpenoids, 1a-3a, and the known metabolites atomaric acid, stypoquinonic acid, and 5'a-desmethyl-5'-acetylatomaric acid have been isolated from the tropical brown alga Stypopodium zonale. The structures and relative stereochemistry of the methyl ester of 1a-3a were determined by spectral methods. The methyl ester of 3a exhibits in vitro cytotoxic activity against human lung and colon carcinoma.
Dorta
Enrique
E
Instituto de Productos Naturales y Agrobiología del CSIC, Avenida Astrofísico F Sánchez 3, Apartado 195, 38206 La Laguna, Tenerife, Spain.
Cueto
Mercedes
M
Brito
Inmaculada
I
Darias
José
J
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms; D008745:Methylation; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D013030:Spain; D017550:Spectroscopy, Fourier Transform Infrared; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D013729:Terpenes