Preoperative assessment of ovarian tumors by CA 125 measurement and transvaginal color Doppler ultrasound.
The accuracy of combined use of serum CA 125 and transvaginal color Doppler for preoperative assessment of ovarian lesions in premenopausal patients was evaluated. Seventy-six ovarian lesions were analyzed the day before surgery using transvaginal color Doppler ultrasound. On the same day, serum CA 125 was measured in each patient. A novel index is proposed for the detection of ovarian malignancy combining resistance index (RI) obtained from newly formed vessels within the ovarian lesion and serum CA 125 level: (RI/CA 125) x 100. Values below the cut-off value of 1.5 were associated with a high risk of ovarian malignancy. Assessment of ovarian lesions by the novel index had a sensitivity and specificity of 94.44% and 100%, while positive and negative predictive values were 100% and 98.31%, respectively. The best prediction of ovarian malignancy was achieved by a combined use of transvaginal color Doppler ultrasound and serum CA 125 in the form of index: (RI/CA 125) x 100.
Kupesić
Sanja
S
Department of Obstetrics and Gynecology, Medical School, University of Zagreb, Sveti Duh General Hospital, HR-10000 Zagreb, Croatia. sanja.kupesic@zg.tel.hr
Vujisić
Sanja
S
Kurjak
Asim
A
Mihaljević
Daria
D
Radosević
Senka
S
D000328:Adult; D018394:CA-125 Antigen / Q000097:blood*; D003536:Cystadenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D011237:Predictive Value of Tests; D017697:Premenopause; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color
D018394:CA-125 Antigen