[Cardiac manifestations in HIV-infected individual].
The human immunodeficiency virus (HIV) does not only affect the immune system. Other organs including the cardiovascular system are influenced by the HIV as well. Most common HIV-associated cardiac manifestations are pericardial effusion and chronic active, focal or diffuse myocarditis. In addition to peri- and myocardial disease, endocardiac manifestations occur as infective endocarditis and nonbacterial thrombotic endocarditis in HIV-infected patients. Although most of the cardiac manifestations associated with HIV-infection exhibit a slow progression, rapid courses may lead to fatal complications. Early screening of HIV-infected patients will identify the potentially fatal complications of HIV disease and permit efficient treatment. The use of highly active antiretroviral therapy (HAART) significantly reduced the mortality and morbidity of HIV-infected patients. However, the impact that HAART will have on the incidence and prevalence of cardiac complications in HIV-infected patients is still unknown. It can be predicted, that the long-term viral infection and the increase of cardiovascular risk factors by HAART will probably lead to an increased prevalence of HIV-infected individuals with cardiac complications in the next decade. The present review describes the most frequent HIV-associated cardiac manifestations including diagnostic and therapeutic perspectives.
Neumann
Till
T
Abteilung für Kardiologie, Universitätsklinikum Essen, Germany. till.neumann@uni-essen.de
Ross
Birgit
B
Hengge
Ulrich R
UR
Gerken
Guido
G
Erbel
Raimund
R
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001344:Autopsy; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis / Q000209:etiology; D004696:Endocarditis / Q000175:diagnosis / Q000209:etiology; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009205:Myocarditis / Q000175:diagnosis / Q000209:etiology; D010490:Pericardial Effusion / Q000175:diagnosis / Q000209:etiology; D012307:Risk Factors; D013997:Time Factors