title: Autoantibodies from an SLE patient immunostain the Barr body.
abstract: To identify specific autoimmune disorders that produce autoantibodies against the mammalian Barr body, sera from 185 autoimmune patients were screened using indirect immunofluorescence on human fibroblasts. Serum from a patient with systemic lupus erythematosus immunostained epi- topes concentrated at the Barr body in female fibroblasts. Such autoantibodies provide a novel tool for characterization of Barr body composition and structure.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
authors.forename: W H
authors.initials: WH
authors.lastname: Brooks
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: B
authors.initials: B
authors.lastname: Hong
authors.forename: W H
authors.initials: WH
authors.lastname: Reeves
authors.forename: T P
authors.initials: TP
authors.lastname: Yang
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology; D002460:Cell Line; D002869:Chromosome Aberrations; D004303:Dosage Compensation, Genetic; D005260:Female; D005347:Fibroblasts; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D066298:In Vitro Techniques; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008297:Male; D012728:Sex Chromatin / Q000276:immunology*
chemical_list: D001323:Autoantibodies