L-Lysine alpha-oxidase: physicochemical and biological properties.
This review summarizes data on the properties of L-lysine alpha-oxidase, an enzyme that belongs to the group of oxidases of L-amino acids. This enzyme acts virtually only on L-lysine with a rather low Km yielding alpha-keto-epsilon-aminocaproic acid. The decrease in the level of the essential amino acid L-lysine and the formation of hydrogen peroxide during the reaction possibly provide the basis for the unique properties of L-lysine alpha-oxidase: cytotoxic, antitumor, antimetastatic, antiinvasive, antibacterial, and antiviral activities, as well as an immunomodulating effect. Native L-lysine alpha-oxidase and its immobilized forms are promising tools for determination of concentration of L-lysine in various biological materials.
Lukasheva
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EV
Department of Biochemistry, Russian Peoples' Friendship University, Moscow, 117198 Russia. lukashev@aha.ru
Berezov
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TT
D000594:Amino Acid Oxidoreductases / Q000097:blood / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D004795:Enzyme Stability; D051379:Mice; D013379:Substrate Specificity; D014242:Trichoderma / Q000201:enzymology*
D000970:Antineoplastic Agents; D000594:Amino Acid Oxidoreductases; C041123:L-lysine oxidase