[Behavioral effects of L-tryptophan and p-chlorophenylalanine after adrenalectomy or dexamethasone administration in rats].
Effects of acute administration of L-tryptophan (L-TRP. 250.0 mg/kg, i.p.) on active avoidance conditioning and "open-field" behavior were studied in male rats after adrenalectomy of dexamethasone administration. L-TRP inhibited the acquisition and reproduction of active avoidance reaction in adrenalectomized and dexamethasone-treated rats. Moreover, L-TRP decreased horizontal locomotor activity and grooming behavior in the "open field" on adrenalectomized rats. On the contrary, p-CPA restored the active avoidance conditioning in adrenalectomized rats and rats with excess of glucocorticoids. Also, p-CPA increased the total locomotor activity and grooming behavior in the "open field" in adrenalectomized rats, but decreased horizontal locomotor activity and enhanced emotional reaction in dexamethasone-treated rats in the "open field".
Fedotova
Iu O
IuO
Anichkov Department of Neuropharmacology, Institute for Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Sapronov
N S
NS
D000315:Adrenalectomy / Q000009:adverse effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D010134:Fenclonine / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014364:Tryptophan / Q000494:pharmacology*
D005938:Glucocorticoids; D012702:Serotonin Antagonists; D012701:Serotonin; D003907:Dexamethasone; D014364:Tryptophan; D010134:Fenclonine