The role of ovarian hormones in preserving cognition in aging.
Hormone replacement therapy is now the standard of care for amelioration of the symptoms of menopause and prevention of osteoporosis. More recently, it has been appreciated that hormone replacement may also have beneficial effects on the brain. This review will contrast the biologic data showing that estrogen has significant neuroprotectant effects on the brain, with data from cross-sectional and epidemiologic studies of women showing that hormone replacement may have beneficial effects for cognition in aging. Together, studies suggest that the temporal pattern of hormone replacement may be critical for maintaining cognitive health in aging.
Janowsky
Jeri S
JS
Departments of Neurology and Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201, USA. janowskj@ohsu.edu
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000187:drug effects; D003072:Cognition Disorders / Q000517:prevention & control*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology* / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
D012739:Gonadal Steroid Hormones; D018377:Neurotransmitter Agents