title: Nutrition, adequacy of dialysis, and clinical outcome in Indo-Asian and White European patients on peritoneal dialysis.
abstract: BACKGROUND
  There is a high incidence of end-stage renal disease in Asians originating from the Indian subcontinent living in the UK. Research to date has focused on the cause of renal disease in Indo-Asians, and their outcome on peritoneal dialysis (PD) is less well studied.
  
  
  OBJECTIVE
  To determine whether nutrition, adequacy of dialysis, and outcome of Indo-Asian patients on PD were similar to those of White European patients.
  
  
  METHODS
  Prospective longitudinal observational study over 2 years.
  
  
  METHODS
  We enrolled 35 Indo-Asians and 35 White Europeans on peritoneal dialysis, closely matched for age, gender, diabetes and duration of renal replacement therapy. At enrolment (>3 months on PD), demographic data was recorded. From enrolment, and at 6-month intervals, dialysis adequacy, nutritional status, hospitalizations, PD infections, and treatment modality changes were recorded.
  
  
  RESULTS
  Dietary protein intake, which was significantly worse in Indo-Asians (particularly vegetarians), declined in all patients over time, along with other measures of nutritional status. Adequacy of dialysis, peritoneal characteristics, and PD infections were similar in Indo-Asian and White patients. Technique failure, and death rate were similar in both groups, but the transplant rate was lower in Indo-Asians.
  
  
  CONCLUSIONS
  Interventions are needed to improve nutritional status in these patients, particularly the Indo-Asian patients. The long-term impact of worse social deprivation and lower transplant rates in Indo-Asians needs to be investigated further.
authors.affiliation: Renal Services, University Hospital Coventry, Walsgrave Hospital, Coventry, UK. Anne.Bakewell@wh-tr.wmids.nhs.uk
authors.forename: A
authors.initials: A
authors.lastname: Bakewell
authors.forename: R
authors.initials: R
authors.lastname: Higgins
authors.forename: M
authors.initials: M
authors.lastname: Edmunds
mesh_terms: D000351:Africa, Eastern / Q000208:ethnology; D001211:Asia, Western / Q000208:ethnology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000208:ethnology / Q000628:therapy*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000502:physiology*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011446:Prospective Studies; D016896:Treatment Outcome