[Thoughts on current management of severe neonatal hyperbilirubinemia].
In recent years, the threat of kernicterus reappeared with the extension of early discharge of newborns. By the same time new knowledge and technologies have improved the management of neonatal hyperbilirubinemia. Early bilirubin measurement helps to identify those newborns who will be at risk of hyperbilirubinemia after discharge. This measurement can be made instantaneously in a non invasive way using a transcutaneous measurement device. Fibreoptic and conventional phototherapies can be modulated according to the nature and the intensity of hyperbilirubinemia. In a near future enzymatic inhibitors such as Sn-mesoporphyrin will be probably available for the treatment of severe hyperbilirubinemia.
Di Maio
M
M
Service de pédiatrie et de réanimation et pathologie néonatale, Ospedale Fatebenefratelli, Benevento, Italie. m.di-maio@voila.fr
Besnier
S
S
D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D008652:Mesoporphyrins / Q000627:therapeutic use; D010351:Patient Discharge; D010789:Phototherapy; D012307:Risk Factors
D008652:Mesoporphyrins; C031468:mesoporphyrin IX