Head trauma and Alzheimer's disease.
The authors describe a case of a 55 year old woman who was diagnosed with Alzheimer's disease 1.5 years after a car accident in which she experienced a mild concussion. Extensive history taking disclosed no cognitive changes prior to the car accident. The case is discussed in view of the inflammation hypothesis regarding Alzheimer's disease and the role of the apolipoprotein E4 genotype of the patient.
Nandoe
Rishi D S
RD
Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, the Netherlands.
Scheltens
Philip
P
Eikelenboom
Piet
P
D000544:Alzheimer Disease / Q000209:etiology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D001284:Atrophy; D001924:Brain Concussion / Q000150:complications*; D002540:Cerebral Cortex / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E