title: How to flip the (redox) switch.
abstract: Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the post-translational modification of reactive protein thiols. Recent studies provide new insights on how different agents that cause redox stress mediate the activation of transcription through distinct and specific pathways.
authors.affiliation: Department of Chemical Engineering, Institute for Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA. georgiou@che.utexas.edu
authors.forename: George
authors.initials: G
authors.lastname: Georgiou
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004220:Disulfides / Q000737:chemistry; D004926:Escherichia coli / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology; D008954:Models, Biological; D009154:Mutation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D017382:Reactive Oxygen Species / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D004220:Disulfides; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D003545:Cysteine