title: Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine.
abstract: Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro. One compound 6-methoxy-5,8 bis(4'-amino-1'-methylbutylamino)quinoline [P(1)] was found to have good gametocytocidal activity against Plasmodium yoelli infected mice at 10mg kg(-1) dose in vivo.
authors.affiliation: Malaria Research Centre, Field Station, Sector III, BHEL, Ranipur, Hardwar-249 403, India. virendradua@hotmail.com
authors.forename: Virendra K
authors.initials: VK
authors.lastname: Dua
authors.forename: Sukesh N
authors.initials: SN
authors.lastname: Sinha
authors.forename: Sukla
authors.initials: S
authors.lastname: Biswas
authors.forename: N
authors.initials: N
authors.lastname: Valecha
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: V P
authors.initials: VP
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009033:Culicidae / Q000382:microbiology; D005854:Germ Cells / Q000187:drug effects; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D033661:Oocysts / Q000187:drug effects; D010084:Oxidation-Reduction; D010967:Plasmodium yoelii / Q000187:drug effects; D011319:Primaquine / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry
chemical_list: D000962:Antimalarials; D013431:Sulfates; D011319:Primaquine