title: Structure of bis(2-acetylpyridine 3-hexamethyleneiminylthiosemicarbazonato) palladium II, a potential antitumor complex.
abstract: The crystal structure of the potential antitumor complex bis(2-acetyppyridine 3-hexamethyleneiminylthiosemicarbazonato)palladium(II) has been solved. The palladium(II) atom is in a square planar environment surrounded by two cis nitrogen atoms and two cis sulfur atoms. The ligands are not equivalent, one being tridentate with (N,N,S) donation, the other being monodentate using only the sulfur atom to coordinate to the metal. The tridentate ligand shows a Z, E, Z configuration while the monodentate ligand shows an E, E, Z. Intermolecular hydrogen bonds stabilize the structure, while the crystal packing is determined by Pd-C, Pd-pi, C-H-pi and pi-pi interactions.
authors.affiliation: Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. dkovala@cc.uoi.gr
authors.forename: Dimitra
authors.initials: D
authors.lastname: Kovala-Demertzi
authors.forename: Mavroudis A
authors.initials: MA
authors.lastname: Demertzis
authors.forename: John R
authors.initials: JR
authors.lastname: Miller
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Frampton
authors.forename: Jerry P
authors.initials: JP
authors.lastname: Jasinski
authors.forename: Douglas X
authors.initials: DX
authors.lastname: West
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C470602:bis(2-acetylpyridine-3-hexamethyleneiminylthiosemicarbazonato)palladium(II); D010165:Palladium