Developments in RNA chemistry, a personal view.
This review describes some of the contributions of chemistry to the RNA field with a personal bias towards the phosphorothioate modification and the derivatives at the ribose 2'-position. The usefulness of these modifications is discussed and documented with some examples.
Eckstein
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Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Str. 3, 37075 Göttingen, Germany. eckstein@em.mpg.de
D000818:Animals; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D009705:Nucleosides / Q000737:chemistry / Q000378:metabolism; D010710:Phosphates / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013873:Thionucleotides / Q000737:chemistry* / Q000378:metabolism
D008670:Metals; D009705:Nucleosides; D010710:Phosphates; D016337:RNA, Catalytic; D013873:Thionucleotides; D012313:RNA