[The influence of recombinant human growth hormones on the systemic metabolism after severe burn].
OBJECTIVE
To explore the influence of recombinant human growth hormones (rhGH) postburn systemic metabolism.


METHODS
Twenty-four burn patients were randomly and equally divided into treatment and control groups. Same amount of rhGH (9 U/d) or isotonic saline was injected subcutaneously to respective patients during 3 approximately 17 postburn days (PBDs). Blood samples were harvested at 3, 10 and 17 PBDs for the determination of serum growth hormone, insulin-like growth factor (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), serum proteins, plasma insulin, plasma glucagons and blood glucose, which were then compared and analyzed between two the groups.


RESULTS
The serum levels of GH, IGF-1, IGFBP-3, serum prealbumin and transferrin in rhGH treatment group were evidently higher than those in control groups at 10 and 17 PBDs (P < 0.05 approximately 0.01). But there was no obvious difference in serum albumin, plasma insulin, glucagon and blood glucose (P > 0.05).


CONCLUSIONS
Small dose of rhGH could promote systemic protein synthesis with no side effects on blood glucose levels.
Chen
Zhongyong
Z
Department of Burns and Plastic Surgery, Urumchi General Hospital of Lanzhou Command of PLA, Urumchi 830000, P.R. China.
Gu
Caizhi
C
Wang
Zhixue
Z
Ye
Xiangbai
X
Wang
Xihua
X
Li
Huijie
H
Shen
Yunbiao
Y
Li
Jinxi
J
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D002056:Burns / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology
D001798:Blood Proteins; D007328:Insulin; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone