Molecular basis of voltage gating of OmpF porin.
OmpF and PhoE from Escherichia coli and related homologous proteins from other Gram-negative bacteria allow the passive transport of small polar molecules across the bacterial outer membrane. In vitro, they exhibit voltage gating depending on the experimental conditions. We review current hypotheses on the underlying molecular mechanism of voltage gating of OmpF porin and show how computer simulations can be used to examine each of the proposed mechanisms.
Robertson
Kindal M
KM
Department of Biological Sciences, University of Calgary, AB, Canada.
Tieleman
D Peter
DP
D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D015640:Ion Channel Gating; D018272:Porins / Q000378:metabolism*; D011487:Protein Conformation
D029968:Escherichia coli Proteins; C109237:OmpF protein; D018272:Porins; C082922:PhoE protein, E coli