SULT1A1 polymorphism and esophageal cancer in males.
Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at codon 213, carries a significantly higher risk for women to develop breast cancer. We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan. Cigarette smoking, areca chewing and alcohol consumption were the major risks for developing esophageal cancer. The frequencies of arg/his in cases and controls were 27.8% (52/187) and 11.0% (34/308), respectively (p < 0.0001). No subjects carried his/his. After adjusting for substance use and other covariates, individuals with arg/his had a 3.53-fold higher risk (95% CI = 2.12-5.87) of developing esophageal cancer than those with arg/arg. Unexpectedly, this positive association was found to be even stronger (adjusted OR = 4.04-4.80) among non-smokers, non-drinkers or non-chewers. Our findings suggest that the SULT1A1 his(213) allele is important in the development of esophageal cancer in men.
Wu
Ming-Tsang
MT
Graduate Institute of Occupational Safety and Health and Department of Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wang
Yi-Ting
YT
Ho
Chi-Kung
CK
Wu
Deng-Chyang
DC
Lee
Yung-Chie
YC
Hsu
Hon-Ki
HK
Kao
Ein-Long
EL
Lee
Jang-Ming
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015239:Arylsulfotransferase; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D015238:Sulfotransferases / Q000235:genetics* / Q000378:metabolism
D017931:DNA Primers; D015238:Sulfotransferases; D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human