[Effects of midodrine on symptomatic hypotension during hemodialysis].
BACKGROUND
Hypotension occurs in 20% of hemodialysis procedures.


OBJECTIVE
To study the effects of midodrine on hypotension during hemodialysis.


METHODS
Ten patients on chronic hemodialysis and with a history of hypotension during the procedure, were studied. They received midodrine 10 mg per os or placebo during 5 dialytic procedures each, in a double blind cross over design.


RESULTS
Blood pressure levels prior to dialysis were similar during the midodrine or placebo administration periods. During dialysis, systolic blood pressure fell 19.3 +/- 28 mmHg with midodrine and 23.4 +/- 28 mmHg with placebo. Diastolic blood pressure fell 7.3 +/- 11.5 mmHg with midodrine and 11.1 +/- 12 mmHg with placebo. The reduction in median arterial pressure was also less pronounced with midodrine.


CONCLUSIONS
Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension.
Cotera
Alejandro
A
Unidad de Atención Nefrológica Continua, Sección de Nefrología, Departamento de Medicina, Hospital Clínico Universidad de Chile. acotera@manquehue.net
Alvo
Miriam
M
Sanhueza
María Eugenia
ME
Elgueta
Leticia
L
Gormaz
Juan Pablo
JP
Ibáñez
Carlos
C
Cuadra
Cristián
C
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000494:pharmacology*; D006435:Renal Dialysis / Q000009:adverse effects*
D000316:Adrenergic alpha-Agonists; D008879:Midodrine