Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection.
Hematopoiesis is regulated by a variety of signals that either originate within a developing cell or are supplied by the surrounding environment in secreted- or contact-dependent forms. This review discusses the effects of one secreted factor, interleukin-7, on the development of B lymphocytes. We describe a molecular mechanism for a crucial checkpoint during B lineage maturation, based on the integration of signals mediated by the pre-B cell receptor, the interleukin-7 receptor, and the environment in which these signals are received.
Fleming
Heather E
HE
Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Department of Immunology, University of Toronto, 610 University Avenue, 7-504 Toronto, Ont., Canada M5G 2M9. heatherf@uhnres.utoronto.ca
Paige
Christopher J
CJ
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins; D015851:Interleukin-7 / Q000276:immunology*; D038041:Lymphopoiesis / Q000502:physiology*; D020935:MAP Kinase Signaling System; D008562:Membrane Glycoproteins; D054420:Pre-B Cell Receptors; D011947:Receptors, Antigen, B-Cell; D013234:Stem Cells / Q000166:cytology
D007136:Immunoglobulins; D015851:Interleukin-7; D008562:Membrane Glycoproteins; D054420:Pre-B Cell Receptors; D011947:Receptors, Antigen, B-Cell