title: New saponins from the starfish Certonardoa semiregularis.
abstract: Ten new saponins designated as certonardosides A-J (1-5, 7-11) and the known halityloside D (6) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis and chemical manipulation. The compounds were evaluated for antiviral activity against HIV, HSV, CoxB, EMCV, and VSV and displayed insignificant activity within the range of noncytotoxic concentrations.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Famei
authors.initials: F
authors.lastname: Li
authors.forename: Naseer
authors.initials: N
authors.lastname: Alam
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-Kyo
authors.initials: CK
authors.lastname: Lee
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013215:Starfish / Q000737:chemistry*; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D012503:Saponins; D013256:Steroids; C471535:halityloside D