[The protective effects of Lycium barbarum polysaccharide on alloxan-induced isolated islet cells damage in rats].
OBJECTIVE
To study the effects of Lycium barbarum polysaccharide (LBP) on alloxan-induced isolated islet cells damage in rats.


METHODS
Isolated islet cells from SD rat were cultured in vitro. SOD activity and MDA content in rat islet cells incubated with alloxan or alloxan combined LBP were measured.


RESULTS
Alloxan induced a significant decrease in SOD activity and a increase in MDA production, which were inhibited by LBP.


CONCLUSIONS
LBP had protective effects on alloxan-induced isolated rat islet ceus damage.
Xu
Manyan
M
School of Life Science, East China Normal University, Shanghai 200062.
Zhang
Hongfeng
H
Wang
Yufei
Y
D000496:Alloxan; D000818:Animals; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000473:pathology*; D032305:Lycium / Q000737:chemistry*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D020011:Protective Agents; D008315:Malondialdehyde; D000496:Alloxan; D013482:Superoxide Dismutase