[The effect of tachykinins microinjections into the solitary tract nucleus on respiration and blood circulation in rats].
Administration of substance P and kassinin into the solitary tract nucleus of anesthetized rats induced a dose-dependent increase in ventilation, tidal volume, inspiratory muscle activity, and a decrease in the mean blood pressure and heart rate. Microinjections of peptides caused a decrease in ventilatory response to hypoxia and an inhibition of the Breuer-Hering reflex. The data obtained suggest involvement of tachykinins in the respiratory and circulatory control via the solitary tract nucleus.
Chepurnov
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SA
Lomonossov State University, 119899, Vorobievy Gory, Moscow, and State University, 443011, Samara, Pavlov St., 1, Russia.
Iniushkin
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AN
D000818:Animals; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D015286:Kassinin / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D008845:Microinjections; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000819:agonists; D018041:Receptors, Neurokinin-2 / Q000819:agonists; D012119:Respiration / Q000187:drug effects*; D017552:Solitary Nucleus / Q000187:drug effects* / Q000502:physiology; D013373:Substance P / Q000494:pharmacology* / Q000502:physiology
D018040:Receptors, Neurokinin-1; D018041:Receptors, Neurokinin-2; D013373:Substance P; D015286:Kassinin