Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands.
A new synthetic methodology to provide cis-2-(1H-imidazol-4-yl)-cyclopropane carboxylic acids is described. These cyclopropanes are useful for the preparation of novel H(3) receptor agents.
Braña
Miguel F
MF
Departamento de Ciencias Qui;micas, Sección de Qui;mica Orgánica y Farmacéutica, Universidad San Pablo CEU, Urb Montepríncipe, Boadilla del Monte 28668, Madrid, Spain. mfbrana@ceu.es
Guisado
Cristina
C
Fernando Alguacil
Luis
L
Garrido
Elisa
E
Pérez-García
Carmen
C
Ruiz-Gayo
Mariano
M
D000818:Animals; D001923:Brain Chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000494:pharmacology; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008761:Methylhistamines / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D013329:Structure-Activity Relationship
D002264:Carboxylic Acids; D003521:Cyclopropanes; D006633:Histamine Antagonists; D008024:Ligands; D008761:Methylhistamines; D018100:Receptors, Histamine H3