title: In vivo physiological changes in the synovial membrane of the knee during reperfusion after arthroscopy. A study using the microdialysis technique.
abstract: We have used in vivo microdialysis to monitor postoperative physiological events in the synovial membrane after arthroscopy. The levels of lactate were significantly higher in the synovial membrane than in the reference tissue (subcutaneous fat) and there was a significant increase in lactate after operation. Blood flow, measured as the ethanol ratio, was stable in both tissues. Our findings show that there was an increase in the local production of lactate since the levels of lactate in blood and the reference tissue were comparable and did not show a significant increase. There was also a consumption of glucose in the synovial membrane which was not observed in the reference tissue. The levels of pyruvate were higher in the synovial membrane. A state of reperfusion occurs in the synovial membrane after moderate trauma such as standard arthroscopy of the knee. Microdialysis should be further evaluated in studies of the in vivo physiology of the synovial membrane.
authors.affiliation: Centre for Surgical Sciences, Division of Orthopaedics, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Felländer-Tsai
authors.forename: E
authors.initials: E
authors.lastname: Högberg
authors.forename: T
authors.initials: T
authors.lastname: Wredmark
authors.forename: P
authors.initials: P
authors.lastname: Arner
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000704:Analysis of Variance; D001182:Arthroscopy; D005260:Female; D006801:Humans; D007719:Knee Joint; D007773:Lactates / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism*
chemical_list: D007773:Lactates