title: Guided ultrasonic waves in long bones: modelling, experiment and in vivo application.
abstract: Existing ultrasound devices for assessing the human tibia are based on detecting the first arriving signal, corresponding to a wave propagating at, or close to, the bulk longitudinal velocity in bone. However, human long bones are effectively irregular hollow tubes and should theoretically support the propagation of more complex guided modes similar to Lamb waves in plates. Guided waves are attractive because they propagate throughout the bone thickness and can potentially yield more information on bone material properties and architecture. In this study, Lamb wave theory and numerical simulations of wave propagation were used to gain insights into the expected behaviour of guided waves in bone. Experimental measurements in acrylic plates, using a prototype low-frequency axial pulse transmission device, confirmed the presence of two distinct propagating waves: the first arriving wave propagating at, or close to, the longitudinal velocity, and a slower second wave whose behaviour was consistent with the lowest order Lamb antisymmetrical (A0) mode. In a pilot study of healthy and osteoporotic subjects, the velocity of the second wave differed significantly between the two groups, whereas the first arriving wave velocity did not, suggesting the former to be a more sensitive indicator of osteoporosis. We conclude that guided wave measurements may offer an enhanced approach to the ultrasonic characterization of long bones.
authors.affiliation: Department of Health Sciences, University of Jyväskylä, Finland. patrick_nicholson@hotmail.com
authors.forename: Patrick H F
authors.initials: PH
authors.lastname: Nicholson
authors.forename: Petro
authors.initials: P
authors.lastname: Moilanen
authors.forename: Tommi
authors.initials: T
authors.lastname: Kärkkäinen
authors.forename: Jussi
authors.initials: J
authors.lastname: Timonen
authors.forename: Sulin
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000180:Acrylic Resins; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D010024:Osteoporosis / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D013977:Tibia / Q000000981:diagnostic imaging*; D014463:Ultrasonography / Q000379:methods*
chemical_list: D000180:Acrylic Resins