title: Changes in human regional cerebral blood flow following hypertonic saline induced experimental muscle pain: a positron emission tomography study.
abstract: A positron emission tomography imaging study was performed on 16 healthy volunteers to reveal changes in cortical activation during acute muscle pain induced by intra-muscular injection of hypertonic saline into the left triceps brachii muscle. Changes in regional cerebral blood flow (rCBF) were measured with the use of [(15)O] labelled water during 'Rest1', 'Needle' (insertion of a needle without injection), 'Rest2' and 'Pain' conditions. Differences in rCBF were found in the comparison of Pain and Needle, and Pain and Rest2 conditions, revealing activation of the contralateral insula and putamen. The results are discussed with respect to possible differences in brain processing of muscle and cutaneous noxious inputs.
authors.affiliation: Center for Musculoskeletal Research, Umeå University and National Institute for Working Life, Box 7654, Petrus Laestadius väg, S907 13, Umeå, Sweden.
authors.forename: Alexander
authors.initials: A
authors.lastname: Korotkov
authors.forename: Milos
authors.initials: M
authors.lastname: Ljubisavljevic
authors.forename: Johan
authors.initials: J
authors.lastname: Thunberg
authors.forename: Galina
authors.initials: G
authors.lastname: Kataeva
authors.forename: Marina
authors.initials: M
authors.lastname: Roudas
authors.forename: Sergey
authors.initials: S
authors.lastname: Pakhomov
authors.forename: Sasa
authors.initials: S
authors.lastname: Radovanovic
authors.forename: Eugene
authors.initials: E
authors.lastname: Lyskov
authors.forename: Sviatoslav
authors.initials: S
authors.lastname: Medvedev
authors.forename: Håkan
authors.initials: H
authors.lastname: Johansson
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D016000:Cluster Analysis; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010103:Oxygen Isotopes; D010146:Pain / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010147:Pain Measurement; D011699:Putamen / Q000000981:diagnostic imaging / Q000503:physiopathology; D012462:Saline Solution, Hypertonic; D011795:Surveys and Questionnaires; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D010103:Oxygen Isotopes; D012462:Saline Solution, Hypertonic