Effect of monoamine oxidase A knockout on resistance to long-term exposure to ethanol.
It was shown that transgenic Tg8 mice with monoamine oxidase A (MAO A) gene knockout demonstrate higher resistance to acute ethanol exposure compared to wild type C3H mice. This difference was observed at the early age (28-30 days). Long-term ethanol treatment changed the resistance to hypnotic, but not hypothermic action of this agent. Seven-day exposure increased the resistance to ethanol-induced narcotic sleep in Tg8 and C3H mice. After 30-day ethanol treatment the duration of narcotic sleep sharply decreased in C3H mice and increased in Tg8 mice, which attested to their decreased tolerance to ethanol.
Ivanova
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Laboratory of Phenogenetics of Behavior, Institute of Cytology and Genetics, Siberian Department of the Russian Academy of Sciences, Novosibirsk. ilen@bionet.nsc.ru
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D000375:Aging; D000428:Alcohol Drinking / Q000235:genetics*; D000818:Animals; D004361:Drug Tolerance / Q000235:genetics; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008995:Monoamine Oxidase / Q000172:deficiency / Q000235:genetics*; D012890:Sleep / Q000187:drug effects / Q000235:genetics; D013997:Time Factors
D000431:Ethanol; D008995:Monoamine Oxidase