title: Antiangiogenic activity of Bupleurum longiradiatum on human umbilical venous endothelial cells.
abstract: The ethyl acetate fraction of Bupleurum longiradiatum was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells. The active compounds, isolated from the fraction, were identified as acetylbupleurotoxin (P1) and bupleurotoxin (P2). The compounds P1 and P2 completely inhibited the tube-like formation of HUVE cells at 30 microg/ml, below the cytotoxic concentration. But, they did not exhibit antitumor activity on BDF1 mice bearing Lewis lung carcinoma cells despite their antiangiogenic activity.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: You
authors.forename: Im-Seon
authors.initials: IS
authors.lastname: Lee
authors.forename: Yong
authors.initials: Y
authors.lastname: Kim
authors.forename: Ki-Hwan
authors.initials: KH
authors.lastname: Bae
authors.forename: Byung-Zun
authors.initials: BZ
authors.lastname: Ahn
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D029972:Bupleurum / Q000737:chemistry; D018827:Carcinoma, Lewis Lung; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D014470:Umbilical Cord / Q000166:cytology / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D010936:Plant Extracts