[Antihypoxic and antiedemic activity of new condensed indole derivatives].
The antihypoxic and antiedemic activity of a series of new indole derivatives and condensed systems, including pyrimido-, thiazolo-, and triazinoindoles, was studied on the hypobaric hypoxic hypoxia ad toxic lung edema models. Several thiazoloindole and formylindole derivatives prevented the loss of experimental animals under hypoxia conditions and significantly reduced the toxic lung edema development. The pharmacological activity of these compounds was comparable with or exceeded that of the standard antihypoxic and antiedemic drugs.
Marysheva
V V
VV
Department of Pharmacology, St. Petersburg State Military Medical Academy, ul. Lebedeva 6, St. Petersburg, 194044 Russia.
Torkunov
P A
PA
Varlashova
M B
MB
Zemlianoĭ
A V
AV
Shabanov
P D
PD
D000818:Animals; D001274:Atmospheric Pressure; D004195:Disease Models, Animal; D000860:Hypoxia / Q000188:drug therapy*; D007211:Indoles / Q000737:chemistry* / Q000627:therapeutic use* / Q000633:toxicity; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010705:Phosgene / Q000633:toxicity; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*
D007211:Indoles; D010705:Phosgene