title: Microwave-assisted (radio)halogenation of nitroimidazole-based hypoxia markers.
abstract: Microwave-assisted radiohalogenation for the production of short-lived radiopharmaceuticals has now been applied to the synthesis and radiolabelling of azomycin nucleosides. (Radio)halogens were incorporated either by nucleophilic substitution of a leaving group or by halogen-halogen exchange, in the synthesis of IAZA, IAZP and FAZA. A comparison of conventional labelling and microwave-assisted labelling procedures reflects a clear advantage of the microwave technique.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Kumar
authors.forename: L I
authors.initials: LI
authors.lastname: Wiebe
authors.forename: M
authors.initials: M
authors.lastname: Asikoglu
authors.forename: M
authors.initials: M
authors.lastname: Tandon
authors.forename: A J B
authors.initials: AJ
authors.lastname: McEwan
mesh_terms: D015415:Biomarkers; D006358:Hot Temperature; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D008872:Microwaves; D009593:Nitroimidazoles / Q000138:chemical synthesis*; D011854:Radiochemistry / Q000379:methods; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D015415:Biomarkers; D007457:Iodine Radioisotopes; D009593:Nitroimidazoles; D019275:Radiopharmaceuticals