Postantibiotic effect and delay of regrowth in strains carrying mutations that save proteins or RNA.
The postantibiotic effect (PAE) values found for proteinase-defective (Lon(-)) Escherichia coli and RNase-defective E. coli exposed to antibiotics were reduced (31 to 60% and 35 to 50%, respectively) in comparison with the control (AB1157), and in the recA13 mutant these values were about 0.4 h with all drugs. Nalidixic acid, under anaerobic conditions, induced no PAE (0 to 0.1 h) in AB1157. A delay in regrowth (0.2 to 0.26 h) was noted with dnaA46(Ts), gyrA43(Ts), and gyrB41(Ts) mutants cultured for 2 h at 43 degrees C. These findings suggest that when proteins and RNA are saved, the cell rapidly resumes the original growth rate.
Dolcino
Marzia
M
Institute of Microbiology C.A. Romanzi, University of Genoa, Italy.
Zoratti
Alberto
A
Debbia
Eugenio A
EA
Schito
Gian Carlo
GC
Marchese
Anna
A
D000583:Amikacin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology; D010641:Phenotype; D012329:RNA, Bacterial / Q000187:drug effects*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D009268:Nalidixic Acid; D002701:Chloramphenicol; D015378:Imipenem; D000583:Amikacin