title: Early carbon dioxide challenge test may predict clinical response in panic disorder.
abstract: We examined whether responses to the carbon dioxide (CO(2)) challenge test were correlated with clinical response. Thirty-four panic disorder patients participated in a CO(2) test after 1 h, 2 weeks and 6 weeks of treatment with clonazepam (2 mg/day) or placebo. The clonazepam group had significantly fewer panic attacks in response to the CO(2) test and the test may predict clinical response.
authors.affiliation: Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro-RJ, Brazil. avalen@uol.com.br
authors.forename: Alexandre M
authors.initials: AM
authors.lastname: Valença
authors.forename: Antonio E
authors.initials: AE
authors.lastname: Nardi
authors.forename: Isabella
authors.initials: I
authors.lastname: Nascimento
authors.forename: Walter A
authors.initials: WA
authors.lastname: Zin
authors.forename: Fabiana L
authors.initials: FL
authors.lastname: Lopes
authors.forename: Marco A
authors.initials: MA
authors.lastname: Mezzasalma
authors.forename: Marcio
authors.initials: M
authors.lastname: Versiani
mesh_terms: D000328:Adult; D002245:Carbon Dioxide; D002998:Clonazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D011237:Predictive Value of Tests; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide; D002998:Clonazepam