title: Severe arteriolar lesion mimicking drug-induced arteriolopathy in a long-term surviving renal allograft.
abstract: We report severe arteriolar lesion mimicking drug-induced arteriolopathy in a renal allograft of a 37-year-old Japanese male, who has been treated by conventional immunosuppressive therapy but not administered cyclosporin or tacrolimus for 16 years after renal transplantation. Renal biopsy also showed glomerular changes including transplant glomerulopathy and features of chronic vascular rejection. The cause of the arteriolar lesion remains uncertain. Although its pathogenesis may be multi-factorial, long-term usage of conventional immunosuppressive agents and/or vascular rejection may contribute to the occurrence of the arteriolar lesion. We propose that biopsy study is needed for further understanding of histopathological behaviours of renal grafts in long-term survivors.
authors.affiliation: Department of Pathology, Nagasaki University School of Medicine, and Renal Care Unit, Nagasaki University Hospital, Japan.
authors.forename: Arifa
authors.initials: A
authors.lastname: Nazneen
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishikido
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Koga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanetake
authors.forename: Diange
authors.initials: D
authors.lastname: Liu
authors.forename: Takashi
authors.initials: T
authors.lastname: Harada
authors.forename: Takashi
authors.initials: T
authors.lastname: Taguchi
mesh_terms: D000328:Adult; D001160:Arterioles / Q000648:ultrastructure*; D001706:Biopsy; D003937:Diagnosis, Differential; D006084:Graft Rejection / Q000473:pathology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male