title: Molecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea.
abstract: CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine beta-synthase (CBS) gene from Saccharomyces cerevisiae. Our studies indicated that M. grisea can utilize homocysteine and methionine through a CBS-independent pathway. The results also revealed responses of M. grisea to homocysteine that are reminiscent of human homocystinuria.
authors.affiliation: Microbial Research, Paradigm Genetics, Inc., Research Triangle Park, North Carolina 27709, USA. clo@paragen.com
authors.forename: Sze Chung Clive
authors.initials: SC
authors.lastname: Lo
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Hamer
authors.forename: John E
authors.initials: JE
authors.lastname: Hamer
mesh_terms: D000595:Amino Acid Sequence; D003540:Cystathionine / Q000737:chemistry; D003541:Cystathionine beta-Synthase / Q000737:chemistry / Q000235:genetics*; D005800:Genes, Fungal; D006710:Homocysteine / Q000494:pharmacology; D020082:Magnaporthe / Q000235:genetics* / Q000254:growth & development; D024101:Mitochondrial Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D010935:Plant Diseases / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D015534:Trans-Activators / Q000235:genetics; D014805:Vitamin B 12 / Q000378:metabolism
chemical_list: C060724:CBS1 protein, S cerevisiae; D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D006710:Homocysteine; D003540:Cystathionine; D003541:Cystathionine beta-Synthase; D014805:Vitamin B 12