title: Calculation of the dielectric properties of biological tissue using simple models of cell patches.
abstract: The measurement of the dielectric properties of biological tissue is of increasing scientific relevance. Models for the comprehension of the dielectric properties at various frequencies have been successfully set up. However, students often have problems in understanding the effects taking place on cellular level which lead to the observed dispersion. A numerical model of a biological tissue brick composed of single cells (micron-dimensions) between two plate electrodes is presented in this study. An electrical current in a range of 1 Hz to 3 GHz was applied to the electrodes and hence to the tissue model. Using an equivalent series circuit of a resistor and a capacitor it is possible to calculate the effective equivalent dielectric properties of the whole tissue model. The results show an increasing conductivity and decreasing permittivity with increasing frequency. This corresponds to experimental results obtained with different biological tissues.
authors.affiliation: Institut für Biomedizinische Technik, IBT, Universität Karlsruhe (TH), Deutschland. mag@ibt.uka.de
authors.forename: M A
authors.initials: MA
authors.lastname: Golombeck
authors.forename: C H
authors.initials: CH
authors.lastname: Riedel
authors.forename: O
authors.initials: O
authors.lastname: Dössel
mesh_terms: D000465:Algorithms; D003196:Computer Graphics; D003198:Computer Simulation; D017097:Electric Impedance; D004574:Electromagnetic Fields; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology*; D008962:Models, Theoretical; D018408:Patch-Clamp Techniques