Prevalence and predictors of HIV-associated weight loss in the era of highly active antiretroviral therapy.
This study was a cross-sectional study of 122 HIV-positive subjects to determine the prevalence and predictors of weight loss in the era of highly active antiretroviral therapy (HAART). Forty per cent reported lipodystrophy, 40% had documented weight loss (mean 6.6 kg). Mean intake 13,400 kJ (118% of estimated requirements calculated using the Harris-Benedict equation). One hundred (82%) were taking antiretroviral therapy. Using forward stepwise logistic regression analysis only viral load (VL) was significantly associated with weight loss when intake, CD4 T-cell count, lipodystrophy, and age were entered into the model with VL (log copies/mL). Every one log increase in HIV VL was associated with an odds of weight loss of 1.58 (P=0.0008). Weight loss is still common in the HAART era. HIV VL was the most significant predictor of weight loss in this sample. Inadequate dietary intake and self-reported lipodystrophy were not related to weight loss in this population.
Batterham
Marijka J
MJ
Department of Nutrition and Dietetics, Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, NSW 2050, Australia. marijka@uow.edu.au
Garsia
Roger
R
Greenop
Philippa
P
D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D003430:Cross-Sectional Studies; D002149:Energy Intake / Q000502:physiology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology; D019247:HIV Wasting Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D008060:Lipodystrophy / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000502:physiology; D015995:Prevalence; D019562:Viral Load; D015431:Weight Loss / Q000502:physiology*