title: Laparoscopic surgery for the management of ovarian endometrioma.
abstract: The purpose of this study was to evaluate the effects of laparoscopic surgery on the symptoms associated with ovarian endometrioma. We also examined serum IL-6 concentrations in patients with endometrioma. Ninety-two patients who underwent laparoscopic surgery for ovarian endometrioma were enrolled in this study. The mean duration of follow-up was 27.6 months. Transvaginal ultrasound examinations revealed a recurrence of endometrioma in 13% of the cases. We evaluated the severity of dysmenorrhea using a 0-3-point verbal rating scale, and found that the dysmenorrhea score was statistically improved after the operation. Follicular growth was preserved in 94%, and the pregnancy rate was 43%. We measured serum IL-6 concentrations in 14 patients with ovarian endometrioma and 4 patients with benign gynecologic disease without endometriosis. IL-6 was significantly higher in patients with endometrioma than in those without endometriosis at the time of diagnosis. The mean serum IL-6 concentration significantly decreased after the operation. In conclusion, laparoscopic surgery is effective for alleviating pain and preserving fertility in patients with endometrioma. Measurements of serum IL-6 concentrations may be useful for the management of endometrioma.
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan. souichi@grape.emd.tottori-u.ac.jp
authors.forename: Souichi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Tasuku
authors.initials: T
authors.lastname: Harada
authors.forename: Tomio
authors.initials: T
authors.lastname: Iwabe
authors.forename: Naoki
authors.initials: N
authors.lastname: Terakawa
mesh_terms: D000293:Adolescent; D000328:Adult; D018394:CA-125 Antigen / Q000097:blood; D004412:Dysmenorrhea / Q000628:therapy; D004715:Endometriosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005298:Fertility; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D010535:Laparoscopy; D008875:Middle Aged; D010049:Ovarian Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006080:Ovarian Follicle / Q000503:physiopathology; D059408:Pain Management; D011247:Pregnancy; D012008:Recurrence; D014463:Ultrasonography
chemical_list: D018394:CA-125 Antigen; D015850:Interleukin-6