title: Controlling the onset of natural cryptosporidiosis in calves with paromomycin sulphate.
abstract: A prospective, controlled-blind field trial was conducted to evaluate the efficacy and safety of paromomycin sulphate, given for 10 days from birth, in preventing natural cryptosporidiosis in calves. In the untreated control group, oocyst shedding and diarrhoea followed the pattern that had occurred on the farm before the trial, consistent with a perinatal infection, whereas in the treated group, the prepatent period was significantly longer than in the control group (P < 0.01) and oocyst shedding and diarrhoea started only after the drug was withdrawn. However, the regimen did not reduce the incidence of disease in the treated group.
authors.affiliation: Institute of Veterinary Animal and Biomedical Sciences, Massey University, Private Bag 11.222, Palmerston North, New Zealand.
authors.forename: A
authors.initials: A
authors.lastname: Grinberg
authors.forename: A
authors.initials: A
authors.lastname: Markovics
authors.forename: J
authors.initials: J
authors.lastname: Galindez
authors.forename: N
authors.initials: N
authors.lastname: Lopez-Villalobos
authors.forename: A
authors.initials: A
authors.lastname: Kosak
authors.forename: V M
authors.initials: VM
authors.lastname: Tranquillo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology / Q000517:prevention & control*; D003457:Cryptosporidiosis / Q000517:prevention & control / Q000662:veterinary*; D016785:Cryptosporidium parvum / Q000302:isolation & purification*; D010303:Paromomycin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010303:Paromomycin