ECaC: the gatekeeper of transepithelial Ca2+ transport.
The epithelial Ca(2+) channels (ECaCs) are primarily expressed in Ca(2+) transporting epithelia and represent a new family of Ca(2+) channels that belong to the superfamily of transient receptor potential (TRP) channels. Two members, namely ECaC1 and ECaC2, have been identified from kidney and intestine, respectively. These channels are the prime target for hormonal control of active Ca(2+) flux from the urine space or intestinal lumen to the blood compartment. This review covers the distinctive properties of these highly Ca(2+)-selective channels and highlights the implications for our understanding of the process of transepithelial Ca(2+) transport.
Hoenderop
Joost G J
JG
Department of Cell Physiology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre Nijmegen, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands.
Nilius
Bernd
B
Bindels
René J M
RJ
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D002762:Cholecalciferol / Q000502:physiology; D004553:Electric Conductivity; D004848:Epithelium / Q000378:metabolism*; D004967:Estrogens / Q000502:physiology; D006801:Humans; D015640:Ion Channel Gating; D017136:Ion Transport; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D050052:TRPC Cation Channels; D050916:TRPV Cation Channels
D015220:Calcium Channels; D004967:Estrogens; D050052:TRPC Cation Channels; D050916:TRPV Cation Channels; C492239:TRPV5 protein, human; D002762:Cholecalciferol; D002118:Calcium