[Prognostic factors and treatment for advanced-stage borderline ovarian tumors].
OBJECTIVE
The aim of this review is to study the incidence, the prognostic factors and the treatment of patients with advanced stage borderline ovarian tumor (BOT) associated with extra-ovarian disease (peritoneal implants and/or nodal disorders).


METHODS
Review of literature data.


RESULTS
BOT were associated with peritoneal implants in 15% to 40%. The strongest prognostic factors are the histologic subtype of peritoneal implants and the presence of residual disease. The surgical treatment is the gold standard with resection of all peritoneal disease. This surgery could be conservative in selected cases in order to preserve fertility. Noninvasive peritoneal implants do not seem to be chemosensitive lesions.


CONCLUSIONS
Histologic subtype of peritoneal implants is the most important prognostic factors in patients with serous BOT and extra-ovarian spread. The prognosis of patients with noninvasive implants is good. Treatment is based on surgery. The (only) indication of adjuvant therapy is BOT associated with invasive implants.
Morice
P
P
Institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif Cedex, France. morice@igr.fr
Camatte
S
S
Rouzier
R
R
Pautier
P
P
Atallah
D
D
Pomel
C
C
Lhomme
C
C
Duvillard
P
P
Castaigne
D
D
D000359:Aftercare / Q000379:methods; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015994:Incidence; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D010052:Ovariectomy; D010062:Ovulation Induction / Q000379:methods; D010534:Peritoneal Neoplasms / Q000556:secondary; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome