Phytochemical constituents of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines.
Five terpenes (1-5), three fatty acids (6-8), two sterols (9 and 11), and a monogalactosyldiacyl glycerol (10) were isolated from the methylene chloride extract of the aerial part of Cirsium setidens. Their chemical structures were determined to be alpha-tocopherol (1), 25-hydroperoxycycloart-23-en-3beta-ol (2), 24-hydroperoxycycloart-25-en-3beta-ol (3), mokko lactone (4), transphytol (5), 9,12,15-octadecatrienoic acid (6), 9,12-octadecadienoic acid (7), hexadecanoic acid (8), acylglycosyl beta-sitosterol (9), (2R)-1,2-O-(9z,12z,15z-dioctadecatrienoyl)-3-O-beta-D-galactopyranosyl glycerol (10) and beta-sitosterol glucoside (11) by spectral evidences. Compound 3 exhibited significant cytotoxic activity against five human cancer cell lines with its ED50 values ranging from 2.66 to 11.25 microM.
Lee
Won Bin
WB
Kwon
Hak Cheol
HC
Cho
Ock Ryun
OR
Lee
Kang Choon
KC
Choi
Sang Un
SU
Baek
Nam In
NI
Lee
Kang Ro
KR
D031180:Cirsium / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D035261:Plant Components, Aerial / Q000737:chemistry / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D014407:Tumor Cells, Cultured
D010936:Plant Extracts