title: Perinatal complication: hypoxic-ischemic encephalopathy.
abstract: The favourable development of foetus is connected with the sufficient oxygen requirement. The brain of the foetus is extraordinarily sensitive to the disorders of oxygen supply. Ischemic brain injury connected with perinatal asfyxia is a frequent cause of hypoxic encephalopathy. An increased tolerance of the brain could be achieved by using peptide grows factors, inhibition of nitric oxide or modifying the glutamate receptors activity. Cerebral hypoxia evolves mainly in the case interruption of the feto-placental circulation or cardiorespiratory failure in the neonate. For making the diagnosis of neonatal encephalopathy is important to determine clinical neurological and systemic deragements in the first few days of life. Assessment of prognosis is generally based on a combination of clinical features and abnormalities of examination methods (electroencephalography, computer tomography).
authors.affiliation: Institute of Physiology, 1st Faculty of Medicine of Charles University, Albertov 5, 128 00 Prague, Czech Republic. iveta.valkounova@lf1.cuni.cz
authors.forename: I
authors.initials: I
authors.lastname: Valkounová
authors.forename: D
authors.initials: D
authors.lastname: Maresová
authors.forename: S
authors.initials: S
authors.lastname: Trojan
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications / Q000503:physiopathology; D002547:Cerebral Palsy / Q000209:etiology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D007231:Infant, Newborn