[Transfer factor modulates inhibitory action of neurotransmitters on intestinal smooth muscles].
It has been shown that Transfer factor (TF) to Staphilococcus aureus antigens blocked ATP-induced component of the inhibitory junction potential in taenia coli smooth muscle from guinea-pig, and converted an inhibitory action of exogenous ATP into an exciting one (instead of the hyperpolarization of the smooth muscle, TF induced its depolarization). TF at 10-6 mg/ml converted the relaxing effects of sodium nitroprusside (nitric oxide donor) into exciting ones in smooth muscle strips. Higher concentrations (10-5-10-3 mg/ml) of TF slightly amplified the relaxing effect of sodium nitroprusside. Both a- and b-adrenergic activation in taenia coli smooth muscle were not sensitive to that agent.
Davydovs'ka
T L
TL
Kyiv Shevchenko National University Physiology Institute.
Filippov
I B
IB
Tsymbaliuk
O V
OV
Shuba
M F
MF
Kholodna
L S
LS
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D006168:Guinea Pigs; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009126:Muscle Relaxation / Q000187:drug effects* / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D014165:Transfer Factor / Q000494:pharmacology*
D014165:Transfer Factor; D000255:Adenosine Triphosphate