title: Cycloartane and oleanane saponins from egyptian astragalus spp. as modulators of lymphocyte proliferation.
abstract: From the roots of Astragalus kahiricus DC., three known saponins, namely, astraversianin VI, astraversianin X, astragaloside VIII, and a new saponin were isolated and identified by spectral data. The structure of the latter was elucidated by spectral means and assigned as cycloastragenol 3- O-[ beta- D-(2',3'-diacetyl, 4'- trans-2-butenoyl)-xylopyranosyl], 6- O- beta- D-xylopyranoside (kahiricoside I). From the aerial parts of A. hamosus L., the known compounds azukisaponin V and peregrinoside I were isolated. As judged by in vitro tests, the saponins isolated from Astragalus spp. endemic to Egypt were not cytotoxic against a variety of human cancer cells. However, dose-related modulation of lymphocyte proliferation was observed, and structure-activity relationships are described.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Milano, Italy. luisella.verotta@unimi.it
authors.forename: Luisella
authors.initials: L
authors.lastname: Verotta
authors.forename: Marco
authors.initials: M
authors.lastname: Guerrini
authors.forename: Nadia A
authors.initials: NA
authors.lastname: El-Sebakhy
authors.forename: Aya M
authors.initials: AM
authors.lastname: Assad
authors.forename: Soad M
authors.initials: SM
authors.lastname: Toaima
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Radwan
authors.forename: Ying-De
authors.initials: YD
authors.lastname: Luo
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D027883:Astragalus Plant; D004305:Dose-Response Relationship, Drug; D004534:Egypt; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D051379:Mice; D008815:Mice, Inbred Strains; D009828:Oleanolic Acid / Q000031:analogs & derivatives; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012503:Saponins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; C085352:cycloartane; D009828:Oleanolic Acid