Biochemical aspects of pressure tolerance in marine mammals.
Some marine mammals can dive to depths approaching 2000 m. At these hydrostatic pressures (200 atm), some fish species show alterations in enzyme structure and function that make them pressure-tolerant. Do marine mammals also possess biochemical adaptations to withstand such pressures? In theory, biochemical alterations might occur at the control of enzymatic pathways, by impacting cell membrane fluidity changes or at a higher level, such as cellular metabolism. Studies of marine mammal tissues show evidence of all of these changes, but the results are not consistent across species or diving depth. This review discusses whether the elevated body temperature of marine mammals imparts pressure tolerance at the biochemical level, whether there are cell membrane structural differences in marine mammals and whether whole, living cells from marine mammals alter their metabolism when pressure stressed. We conclude that temperature alone is probably not protective against pressure and that cell membrane composition data are not conclusive. Whole cell studies suggest that marine mammals either respond positively to pressure or are not impacted by pressure. However, the range of tissue types and enzyme systems that have been studied is extremely limited and needs to be expanded before more general conclusions about how these mammals tolerate elevated pressures on a biochemical level can be drawn.
Castellini
Michael A
MA
Institute of Marine Science, University of Alaska Fairbanks, Fairbanks, AK 99775, USA. mikec@ims.uaf.edu
Rivera
Patricia M
PM
Castellini
Judith M
JM
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D004242:Diving / Q000502:physiology*; D008560:Membrane Fluidity / Q000502:physiology; D011312:Pressure; D046048:Seals, Earless / Q000502:physiology*