title: A solitary minute thyroid lymphoma of MALT-type without lymphoid thyroiditis.
abstract: Most of the primary thyroid malignant lymphomas have been considered of mucosa-associated lymphoid tissue (MALT) type and arise from lymphocytic thyroiditis. We report an uncommon case of a 67-yr-old man who underwent total thyroidectomy for multinodular goiter with tracheal compression. At histopathologic examination, we discovered a minute (3-mm diameter) lesion of low-grade thyroid lymphoma of MALT type without any lymphocytic thyroiditis lesion on 33 section levels of the entire thyroid gland. No general inflammatory, autoimmune, or lymphomatous disorder has been evidenced both at staging and after 30 mo of follow-up. MALT-type low-grade lymphoma may, in some instances, develop de novo within the thyroid without an antecedent MALT-type lymphoma.
authors.affiliation: Department of Pathology, Hôpital du Haut-Lévêque, CHU Bordeaux, Pessac Cedex, France. helene.trouette@chu-bordeaux.fr
authors.forename: Hélène
authors.initials: H
authors.lastname: Trouette
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubus
authors.forename: Geneviève
authors.initials: G
authors.lastname: Belleannee
authors.forename: Marie-Chrstine
authors.initials: MC
authors.lastname: Charmoy
authors.forename: Marie
authors.initials: M
authors.lastname: Parrens
authors.forename: Jean François
authors.initials: JF
authors.lastname: Velly
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Merlio
authors.forename: Antoine
authors.initials: A
authors.lastname: de Mascarel
mesh_terms: D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008297:Male; D016133:Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D013967:Thyroiditis, Autoimmune / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains