High rate of monoclonal gammopathy among immunocompetent subjects with primary cytomegalovirus infection.
Serum samples from immunocompetent adults with primary cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infection and from solid-organ or bone marrow transplant recipients with primary CMV infection were examined for paraproteins. Several immunocompetent patients with CMV infection but none with EBV infection presented with an M component, which implies that the M component connects CMV infection to a risk of B cell malignancy.
Bühler
Suvi
S
Department of Virology, Helsinki University Central Hospital, FIN-00029 HUCH, Helsinki, Finland. suvi.buhler@hus.fi
Laitinen
Kalevi
K
Holthöfer
Harry
H
Järvinen
Asko
A
Schauman
Knut-Olof
KO
Hedman
Klaus
K
D000293:Adolescent; D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009194:Myeloma Proteins / Q000032:analysis; D010265:Paraproteinemias / Q000209:etiology / Q000276:immunology* / Q000378:metabolism
D007075:Immunoglobulin M; D009194:Myeloma Proteins