[Clinical usefulness of blood cultures in hospitalized patients with community-acquired pneumonia].
BACKGROUND
The clinical role of blood cultures (BC) in the management of hospitalized patients with community-acquired pneumonia (CAP) is controversial.


OBJECTIVE
To evaluate the clinical usefulness of blood cultures in CAP.


METHODS
We prospectively studied 244 immunocompetent adults with two or more BC obtained at admission. The diagnostic yield of BC and its impact on antibiotic therapy were assessed.


RESULTS
Mean age (mean +/- sd) of patients was 67 +/- 20 years, 80% had underlying diseases and 29% received antibiotics prior to admission. Hospital length of stay was 10.4 +/- 10 days and global mortality was 7%. The diagnostic yield of BC was only 8.2% (20 patients). Mortality was significantly higher in patients with positive BC (20%) than in those with negative BC (5.8%). In only one of the 20 patients with positive BC (0.4% of total study population), attending physicians changed empiric antimicrobial therapy based on these results.


CONCLUSIONS
This study confirms that the diagnostic yield of BC in CAP hospitalized patients is low, that mortality in bacteremic patients is high and suggests that clinical usefulness of BC to guide changes on empiric antimicrobial therapy is limited, in part because attending physicians seldom use such information.
Díaz
Alejandro
A
Departamento de Enfermedades Respiratorias, Pontificia Universidad Católica de Chile, Marcoleta 345, Santiago, Chile. alediazf@hotmail.com
Calvo
Mario
M
O'Brien
Andrés
A
Farías
Gonzalo
G
Mardónez
José Miguel
JM
Saldías
Fernando
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D011446:Prospective Studies
D000900:Anti-Bacterial Agents