Mycoplasma hominis and Ureaplasma species brain abscess in a neonate.
We report an infant with a mixed Mycoplasma and Ureaplasma brain abscess who was successfully treated with intravenous doxycycline and erythromycin. Therapeutic concentrations of doxycycline were demonstrated in cerebrospinal fluid. This report is evidence of the potential for Mycoplasma and Ureaplasma to produce focal central nervous system infection, as well as meningitis, in neonates and that use of doxycycline can be efficacious in the therapy of such infections.
Rao
Rohit P
RP
Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, USA.
Ghanayem
Nancy S
NS
Kaufman
Bruce A
BA
Kehl
K Sue
KS
Gregg
David C
DC
Chusid
Michael J
MJ
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D009175:Mycoplasma Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D019535:Mycoplasma hominis / Q000302:isolation & purification*; D014509:Ureaplasma / Q000302:isolation & purification*; D016869:Ureaplasma Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D004318:Doxycycline