title: Specificity in signaling by c-Yes.
abstract: c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases, there is also a growing body of evidence to indicate specificity in signaling. In this review, we summarize c-Yes, its potential functions and its ability to modulate signals that are distinct from c-Src.
authors.affiliation: Dept. of Microbiology and Immunology and Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown WV 26506-9300, USA.
authors.forename: Justin M
authors.initials: JM
authors.lastname: Summy
authors.forename: Marius
authors.initials: M
authors.lastname: Sudol
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Eck
authors.forename: Alvaro N
authors.initials: AN
authors.lastname: Monteiro
authors.forename: Amanda
authors.initials: A
authors.lastname: Gatesman
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Flynn
mesh_terms: D000818:Animals; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051575:Proto-Oncogene Proteins c-yes; D015398:Signal Transduction / Q000502:physiology*; D013379:Substrate Specificity; D019061:src-Family Kinases
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D051575:Proto-Oncogene Proteins c-yes; D019061:src-Family Kinases