Nonulcer dyspepsia.
Nonulcer dyspepsia is a common condition in clinical practice. It is a heterogeneous disorder, and no single therapeutic agent is effective in all patients. The treatment of nonulcer dyspepsia is still dissatisfactory. Eradication of Helicobacter pylori organisms has a limited role and little effect. Antisecretory therapy has a modest effect in alleviating symptoms. Prokinetic agents may be effective, but selection bias in the trials performed to date may exaggerate their benefit. Partial 5-HT(4) agonists stimulate gastric emptying and may also affect gastric accommodation. They are promising but need further study. Data are limited on 5-HT(3) antagonists and hypnotherapy. New treatment approaches are necessary for this common and often chronic condition.
Vakil
Nimish
N
Division of Gastroenterology, Department of Medicine, University of Wisconsin Medical School, Aurora Sinai Medical Center, Milwaukee, WI 53233, USA. nvakil@wisc.edu
D000934:Antifoaming Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000175:diagnosis / Q000628:therapy*; D016099:Endoscopy, Gastrointestinal; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D015201:Meta-Analysis as Topic; D016896:Treatment Outcome
D000934:Antifoaming Agents; D005765:Gastrointestinal Agents; D007211:Indoles; C105050:tegaserod