Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor.
Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction).
Smakhtin
M Yu
MY
Department of Pathophysiology, Kursk State Medical University. big@ksmu.kursknet.ru
Sever'yanova
L A
LA
Konoplya
A I
AI
Shveinov
I A
IA
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007116:Immunization, Passive; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D008940:Mitotic Index; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007166:Immunosuppressive Agents; D009842:Oligopeptides; C020905:glycyl-histidyl-lysine