Protective effect of diltiazem, a L-type calcium channel antagonist, on bisphenol A-enhanced hydroxyl radical generation by 1-methyl-4-phenylpyridinium ion in rat striatum.
The present study examined whether bisphenol A enhanced 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in rat striatum using microdialysis technique. These elevations were detected by increases in non-enzymatic formation of 2,3-dihydroxybenzoic acid levels. Bisphenol A significantly enhanced MPP+-induced.OH generation. Further, the effect of diltiazem, a L-type Ca2+ channel antagonist, on bisphenol A (10 microM) and MPP+ (5 mM)-induced.OH generation were studied. Ddiltiazem (100 microM) significantly suppressed bisphenol A and MPP+-induced.OH generation. The results indicate bisphenol A augmented *OH generation, and diltiazem may have preventive effect on bisphenol A and MPP+-induced.OH generation.
Obata
Toshio
T
Department of Pharmacology and Therapeutics, Oita Medical University, 1-1 Idaigaoka, Hasama, Oita 879-5593, Japan. tobata@oita-med.ac.jp
Kinemuchi
Hiroyasu
H
Aomine
Masahiro
M
D015655:1-Methyl-4-phenylpyridinium / Q000633:toxicity*; D000818:Animals; D001559:Benzhydryl Compounds; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004110:Diltiazem / Q000494:pharmacology*; D004347:Drug Interactions; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D000098826:Bisphenol A Compounds
D015655:1-Methyl-4-phenylpyridinium; D001559:Benzhydryl Compounds; D002121:Calcium Channel Blockers; D004110:Diltiazem; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds