[Therapeutic effect of puerarin therapy on sudden deafness].
OBJECTIVE
To evaluate the therapeutic effect of puerarin in the treatment against sudden deafness.


METHODS
Seventy-two patients with sudden deafness were randomly assigned into therapeutic group (n= 40) who received intravenous infusion of puerarin injection and the control group (n=32) who were given intravenous infusion of anisodamine. The therapeutic effects of the two treatments were observed and compared.


RESULTS
The total efficacy rates against sudden deafness and tinnitus in the therapeutic group were 89.68 % and 84.37 % respectively, but only 62.5 % and 56.52 % respectively in the control group, showing significant difference (P<0.05).


CONCLUSIONS
Puerarin is effective in dilating the blood vessels and promoting microcirculation of the inner ear, with significant therapeutic effect in the treatment of sudden deafness.
Liu
Jian-Min
JM
Department of Otorhinolaryngology, Shenzhen Hospital of Guangdong General Command of Border Defense of Armed Police, China 518029.
Ma
Li
L
He
Wei-Ping
WP
D000328:Adult; D005260:Female; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012991:Solanaceous Alkaloids / Q000627:therapeutic use; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
D007529:Isoflavones; D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; C033607:puerarin