title: Synthesis and biological evaluation of cytotoxic 6(7)-alkyl-2-hydroxy-1, 4-naphthoquinones.
abstract: Various Diels Alder cycloaddition conditions have been used to optimise the preparation of cytotoxic 6-alkyl-1, 4-naphthoquinones, which were subsequently transformed into 6(7)-alkyl-2-hydroxy-1, 4-naphthoquinones. The compounds thus prepared were evaluated for their cytotoxic activity against several neoplastic cultured cell lines and some of them showed IC50 values below the microM level.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007 Salamanca, Spain. jmmcs@usal.es
authors.forename: José M
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: Castro
authors.forename: Marina
authors.initials: M
authors.lastname: Gordaliza
authors.forename: Maria Luz
authors.initials: ML
authors.lastname: Martin
authors.forename: Alaide B
authors.initials: AB
authors.lastname: Oliveira
authors.forename: Simone A
authors.initials: SA
authors.lastname: Gualberto
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: García-Grávalos
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009285:Naphthoquinones