[Immunomodulating action of fat-soluble vitamins after intense physical loading at low ambient temperatures].
Introduced separately, preparations of the fat-soluble vitamins A, E and K decreased the expression of changes in the immunological reactivity and nonspecific resistance of Wistar rats after a 4-h swimming in water at a temperature of 10 +/- 2 degrees C. Joint administration of the vitamin preparations A + E or A + K normalized both the the immunological reactivity and nonspecific resistance of rats after cold swim test, while the joint introduction of vitamins E + K produces no such effect.
Avakian
A R
AR
Biochemistry Department, Kursk State Medical University, ul. K. Marksa 3a, Kursk, 305041 Russia.
Brovkina
I L
IL
Lazarev
A I
AI
Uteshev
B S
BS
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003080:Cold Temperature; D004357:Drug Synergism; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D009043:Motor Activity / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology; D014812:Vitamin K / Q000008:administration & dosage / Q000494:pharmacology; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D014815:Vitamins; D014801:Vitamin A; D014812:Vitamin K; D014810:Vitamin E