Depression and cardiac morbidity 5 years after coronary artery bypass surgery.
The purpose of this study was to determine whether depression 1 month after coronary artery bypass surgery would be associated with greater cardiac morbidity in patients 5 years later. The cardiac symptom most affected by depression was the recurrence of angina. Factors associated with a return of angina at 5 years were depression measured preoperatively, at 1 month, at 1 year, and at 5 years. Additional significant factors were male sex and a preoperative history of smoking, percutaneous transluminal coronary angioplasty, or cerebrovascular accident. When these factors were combined in multiple logistic regression analyses, the score on the Center for Epidemiologic Studies Depression Scale at 1 month was the most significant of all factors. The depression score at 1 month after coronary artery bypass surgery is an important indicator of cardiac morbidity up to 5 years later.
Borowicz
Louis
L
Zanvyl Krieger Mind/Brain Institute, Department of Neurology, Johns Hopkins School of Public Health, Baltimore, MD 21287, USA. lborowil@jhmi.edu
Royall
Richard
R
Grega
Maura
M
Selnes
Ola
O
Lyketsos
Constantine
C
McKhann
Guy
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000209:etiology / Q000523:psychology; D001026:Coronary Artery Bypass / Q000401:mortality / Q000523:psychology*; D003866:Depressive Disorder / Q000150:complications* / Q000523:psychology*; D005260:Female; D006331:Heart Diseases / Q000401:mortality / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors