title: Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft.
abstract: We analyzed a prostate cancer xenograft derived from a locally advanced tumor using combined cytogenetic, array-based comparative genomic hybridization and expression analyses. This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor. The expression pattern of these genes was then confirmed in two large human prostate cancer microarray databases. Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. Our data suggest these genes to be involved in advanced stages of prostate tumorigenesis and as such, they may serve as markers for tumor progression.
authors.affiliation: Genetic Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel.
authors.forename: Anat
authors.initials: A
authors.lastname: Bar-Shira
authors.forename: Jehonathan H
authors.initials: JH
authors.lastname: Pinthus
authors.forename: Uri
authors.initials: U
authors.lastname: Rozovsky
authors.forename: Myriam
authors.initials: M
authors.lastname: Goldstein
authors.forename: William R
authors.initials: WR
authors.lastname: Sellers
authors.forename: Yuval
authors.initials: Y
authors.lastname: Yaron
authors.forename: Zelig
authors.initials: Z
authors.lastname: Eshhar
authors.forename: Avi
authors.initials: A
authors.lastname: Orr-Urtreger
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D064096:Aurora Kinase A; D064127:Aurora Kinases; D029563:Cellular Apoptosis Susceptibility Protein / Q000096:biosynthesis / Q000235:genetics; D002871:Chromosome Banding; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D030541:Databases, Genetic; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis / Q000235:genetics; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics; D014183:Transplantation, Heterologous
chemical_list: D029563:Cellular Apoptosis Susceptibility Protein; D015534:Trans-Activators; C113698:ZNF217 protein, human; C576917:AURKA protein, human; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases