title: Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.
abstract: Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.
authors.affiliation: Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Borstnik
authors.forename: Ik-hyeon
authors.initials: IH
authors.lastname: Paik
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Shapiro
authors.forename: Gary H
authors.initials: GH
authors.lastname: Posner
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D015195:Drug Design; D010545:Peroxides; D010961:Plasmodium / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010545:Peroxides; D012717:Sesquiterpenes; C467230:yingzhaosu A; C031327:artemisinin