[Activated protein C resistance and deep venous thrombosis in pregnancy].
OBJECTIVE
The aim of the study was to detect the incidence of resistance to activated protein C in pregnant or puerperal women with confirmed diagnosis of deep venous thrombosis or pulmonary embolism.


METHODS
Case-control study.


METHODS
Dept. of Obstetrics and Gynaecology, Dept. of Haemato-oncology, Medical Faculty, Palacky University, Olomouc.


METHODS
The group of 33 women with confirmed deep venous thrombosis were examined for resistance to activated C protein. The levels of C and S proteins, antithrombin III., prothrombin, heparin II cofactor and plasminogen were measured. Patient with APC ratio below 1.86, were tested by PCR analysis for the detection of the FV:Q506 allele. The control group had 51 pregnant women, chosen randomly. The statistical evaluation was performed by STATISTICA program. For the analyzing of the continuous variables the Students' T-test was used. For the categorical variables the chi 2 test was used (for comparison of 2 relative values). Values below P < 0.01 were considered to be statistically significant.


RESULTS
Women who have shown to suffer from deep venous thrombosis (DVT) came to the mean age of 31 +/- 3.1 years, weight 75.3 +/- 7.9 kg and BMI 28.7 +/- 4.3. All of the results above were rendered to be statistically significant. 54.5% of thrombosis occurred in the 3rd trimester, 61% were localised to the left iliofemoral vein. APC resistance appeared in 17 (51%) women with DVT, in comparison to 5 (9.8%) women in the control group (i.e. statistically significant). Factor V appeared in II (33.3%) women, in comparison to 3 (5.9%) women in the control group.


CONCLUSIONS
APC resistance and factor V. Leiden represent as important factors in the aetiology of deep venous thrombosis in pregnancy.
Procházka
M
M
Porodnicko-gynekologická klinika FN a LF UP Olomouc.
Krcová
V
V
Hrachovec
P
P
Kudela
M
M
Slavík
L
L
D020016:Activated Protein C Resistance / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D000328:Adult; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D017354:Point Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000175:diagnosis*; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V