title: Antithrombotic activity of N,N-dichlorotaurine on mouse model of thrombosis in vivo.
abstract: Intravenous injection of chloramine derivatives of amino acids and taurine reduced the mortality rate in mice with thrombosis induced by intravenous injection of ADP or collagen-epinephrine mixture. Intravenous injection of N,N-dichlorotaurine caused 50% inhibition of platelet aggregation induced by ADP and measured in the platelet-enriched plasma in vitro. The antithrombotic effect of chloramine derivatives of amino acids and taurine is related to their ability to suppress functional activity of platelets.
authors.affiliation: Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow. marina_murina@mail.ru
authors.forename: M A
authors.initials: MA
authors.lastname: Murina
authors.forename: O D
authors.initials: OD
authors.lastname: Fesenko
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
authors.forename: N A
authors.initials: NA
authors.lastname: Chudina
authors.forename: D I
authors.initials: DI
authors.lastname: Roshchupkin
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D002700:Chloramines / Q000494:pharmacology*; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010974:Platelet Aggregation; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013927:Thrombosis / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000596:Amino Acids; D002700:Chloramines; D005343:Fibrinolytic Agents; C454660:N,N-dichlorotaurine; D013654:Taurine; D000244:Adenosine Diphosphate