title: Mercapturic acids in the biological monitoring of occupational exposure to chemicals.
abstract: This paper reviews several procedures for determination of mercapturic acids in urine. Special attention was paid to methods useful in relation to human exposure to industrial pollutants, without any description for less sensitive methods used in animal research. Gas chromatographic and liquid chromatographic procedures were considered together with the little information available about thin layer chromatography and immunochemical techniques. After a description of the main industrial pollutants which lead to synthesis of their specific mercapturic acids, the methods for analysing these products are synthetically reported. The comparison among difficulties in sample preparation, complexity of instrumentation and their cost/benefit ratio are discussed.
authors.affiliation: Medicina del Lavoro, Department of Medicine and Public Health, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy. perbelui@mail.univr.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Perbellini
authors.forename: Nello
authors.initials: N
authors.lastname: Veronese
authors.forename: Andrea
authors.initials: A
authors.lastname: Princivalle
mesh_terms: D000111:Acetylcysteine / Q000652:urine*; D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D016273:Occupational Exposure
chemical_list: D000111:Acetylcysteine