[The effect of nitric oxide synthase blockers, nitric oxide donors, and anti-ovarian antibodies on murine oocytes].
The effects of NO synthase (NOS) blockers, NO donors, and anti-ovarian antibodies (AOABs) on the amount of oocytes isolated from murine ovary and their meiotic maturation were studied. It was established that the NOS blockers inhibit the their meiotic maturation of oocytes, while NO donors influenced neither the number of oocytes nor their ability to meiotic maturation in diaestrus or oestrous cycle. The AOAB effect on the gametogenesis was dose-dependent: inhibition for large doses and activation for small doses. The NO/NOS ovarian system is involved into mechanism of the AOAB action on murine oocytes. It is suggested that a decrease in the ovarian NO production, as well as the AOAB-induced inhibition of the murine oogenesis, are factors influencing female infertility.
Voznesenskaia
T Iu
TIu
Department of Immunology and Cytosera, Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, ul. Bogomoltsa 4, Kiev 01024, Ukraine.
Blashkiv
T V
TV
D000818:Animals; D001323:Autoantibodies / Q000494:pharmacology*; D005260:Female; D008540:Meiosis / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D009569:Nitric Oxide / Q000096:biosynthesis*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D009865:Oocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010053:Ovary / Q000276:immunology*
D001323:Autoantibodies; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase