Superior safety of reboxetine over amitryptiline in the elderly.
Under antidepressive treatment with amitryptiline (100 mg/d) a 71-year old woman developed delirious symptoms, hyponatremia and a grand mal seizure followed by cardiovascular arrest. A few month later she ingested 48 mg reboxetine with suicidal intent. Overdosing of reboxetine, a selective noradrenaline re-uptake inhibitor, proceeded without complications.
Agelink
Marcus W
MW
Dept. of Biological Psychiatry and Neuroscience, Evangl. Clinics Gelsenkirchen, Ruhr-University of Bochum, Munckelstr, Germany. EurJMedRes@t-online.de
Ullrich
H
H
Passenberg
P
P
Sayar
K
K
Brockmeyer
N H
NH
D000368:Aged; D000639:Amitriptyline / Q000009:adverse effects* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009025:Morpholines / Q000627:therapeutic use*; D000077593:Reboxetine; D013406:Suicide, Attempted / Q000523:psychology*
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D009025:Morpholines; D000639:Amitriptyline; D000077593:Reboxetine