title: In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes.
abstract: Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.
authors.affiliation: Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
authors.forename: T B
authors.initials: TB
authors.lastname: Kazakova
authors.forename: S V
authors.initials: SV
authors.lastname: Barabanova
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: M S
authors.initials: MS
authors.lastname: Glushikhina
authors.forename: E P
authors.initials: EP
authors.lastname: Parkhomenko
authors.forename: V V
authors.initials: VV
authors.lastname: Malinin
authors.forename: E A
authors.initials: EA
authors.lastname: Korneva
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D007376:Interleukin-2 / Q000235:genetics*; D051379:Mice; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects; D013997:Time Factors
chemical_list: D004151:Dipeptides; D007376:Interleukin-2; D009842:Oligopeptides; D010455:Peptides; C431545:alanyl-glutamyl-aspartylprolyine; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine