title: Highly oxygenated triterpenes from the roots of Atropa acuminata.
abstract: Two new oleanane triterpenes; 2alpha,3alpha,24-trihydroxyolean-12-ene-28,30-dioic acid ([structure: see text]) and 2alpha,3alpha,24,28-tetrahydroxyolean-12-ene ([structure: see text]) have been isolated from the roots of Atropa acuminata. Anti-oxidant p-hydroxyphenethyl trans-ferulate ([structure: see text]), beta-sitosterol-3-O-beta-D-glucopyranoside ([structure: see text]) and oleanolic acid ([structure: see text]) have also been reported for the first time from this species. The structures were determined by spectroscopic studies including 2D-NMR.
authors.affiliation: International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Arshad
authors.initials: A
authors.lastname: Mehmood
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.forename: Pir Mohammad
authors.initials: PM
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Riaz
authors.forename: Talat
authors.initials: T
authors.lastname: Makhmoor
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032282:Atropa / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010154:Pakistan; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C472602:2,3,24,28-tetrahydroxyolean-12-ene; C472601:2,3,24-trihydroxyolean-12-ene-28,30-dioic acid; D000975:Antioxidants; D003373:Coumaric Acids; D005960:Glucosides; D012855:Sitosterols; D014315:Triterpenes; C472603:hydroxyphenethylferulate; C472604:sitosterol-3-O-glucopyranoside; D009828:Oleanolic Acid