title: [Ion channels in nerve ending].
abstract: The modern data about the structure and function of the nerve ending ion channels are generalized and systematized. Ion channels of nerve endings provide the forming of the rest membrane potential, excitability, generation of action potential, regulate the intracellular concentration of calcium ions, take part in exocytosis of synaptic vesicules, participate in short-term and long-term synaptic plasticity, ensure the modulation of presynaptic functions. Methods of investigation of ion channels and data about their localization in central and peripheral nerve systems are represented. The review gives the functional characteristics, molecular structure and mechanisms of regulation of the known voltage- and ligand-dependent ion channels, the role of the certain types of ion channels in the machinery of transmitter release.
authors.affiliation: Medical University, State University, Kazan.
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
authors.forename: G F
authors.initials: GF
authors.lastname: Sitdikova
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D018118:Chloride Channels / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D009411:Nerve Endings / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D015220:Calcium Channels; D018118:Chloride Channels; D007473:Ion Channels; D018377:Neurotransmitter Agents; D015221:Potassium Channels; D015222:Sodium Channels