Lipoprotein lipase: genetics, lipid uptake, and regulation.
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.
Merkel
Martin
M
Department of Medicine, University of Hamburg, Hamburg, Germany. Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA.
Eckel
Robert H
RH
Goldberg
Ira J
IJ
D002914:Chylomicrons / Q000097:blood; D005786:Gene Expression Regulation / Q000502:physiology; D014644:Genetic Variation; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D009154:Mutation; D009206:Myocardium / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism; D009928:Organ Specificity
D002914:Chylomicrons; D008071:Lipoprotein Lipase