Positional information: knowing where you are in a limb.
In the regenerating amphibian limb, positional information has traditionally been considered in terms of short-range cell-cell interactions, not long-range diffusion gradients. A molecule discovered in a differential screen of regenerating limbs turns out to be precisely such a cell surface component, the newt ortholog of mouse CD59.
Maden
Malcolm
M
MRC Centre for Developmental Neurobiology, King's College London, 4th floor New Hunt's House, Guy's Campus, London Bridge, SE1 1UL, London, UK. malcolm.maden@kcl.ac.uk
D000663:Amphibians; D000818:Animals; D018957:CD59 Antigens / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D005121:Extremities / Q000502:physiology*; D051379:Mice; D011187:Posture; D011434:Proprioception; D012038:Regeneration / Q000502:physiology*; D012455:Salamandridae
D018957:CD59 Antigens