title: Fanconi syndrome and renal failure induced by tenofovir: a first case report.
abstract: Although nephrotoxicity of cidofovir and adefovir is well established, no renal side effects have been observed yet with tenofovir, which is the third member of this family. The authors report the case of a patient who had Fanconi syndrome, nephrogenic diabetes insipidus, and acute renal failure during treatment with tenofovir, a nucleotide reverse transcriptase inhibitor that recently has been approved by the Food and Drug Administration for treatment of patients infected with human immunodeficiency virus.
authors.affiliation: Department of Nephrology, Hôpital Tenon (AP-HP), Paris, France. verhelsttenon@yahoo.fr
authors.forename: David
authors.initials: D
authors.lastname: Verhelst
authors.forename: Matthieu
authors.initials: M
authors.lastname: Monge
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Meynard
authors.forename: Bruno
authors.initials: B
authors.lastname: Fouqueray
authors.forename: Béatrice
authors.initials: B
authors.lastname: Mougenot
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
authors.forename: Pierre
authors.initials: P
authors.lastname: Ronco
authors.forename: Jerome
authors.initials: J
authors.lastname: Rossert
mesh_terms: D000225:Adenine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D005198:Fanconi Syndrome / Q000139:chemically induced*; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000139:chemically induced*; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D000068698:Tenofovir; D000225:Adenine