title: Breast carcinoma: a report on the potential usage of the CC chemokine RANTES as a marker for a progressive disease.
abstract: BACKGROUND
  High incidence and intensity of RANTES (CC chemokine) expression were noted in advanced breast carcinoma.
  
  
  OBJECTIVE
  To present two cases of breast carcinoma patients in whom RANTES expression was analyzed in parallel to disease progression.
  
  
  RESULTS
  Although no evidence of malignancy was detected in the axillary lymph nodes of the two patients, their disease progressed. The expression of RANTES in both patients was positive at diagnosis and predicted the clinical course.
  
  
  CONCLUSIONS
  These results, combined with our previous findings on the correlation between RANTES expression and advanced breast carcinoma, suggest that the assessment of RANTES expression may be useful for the identification of patients with apparently poor prognosis who may benefit from aggressive treatment. The above results call for large-scale studies by numerous research groups to determine the prognostic value of RANTES expression.
authors.affiliation: Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Nely
authors.initials: N
authors.lastname: Wigler
authors.forename: Sima
authors.initials: S
authors.lastname: Shina
authors.forename: Ofer
authors.initials: O
authors.lastname: Kaplan
authors.forename: Galia
authors.initials: G
authors.lastname: Luboshits
authors.forename: Samario
authors.initials: S
authors.lastname: Chaitchik
authors.forename: Iafa
authors.initials: I
authors.lastname: Keydar
authors.forename: Adit
authors.initials: A
authors.lastname: Ben-Baruch
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000032:analysis* / Q000235:genetics; D019742:Chemokines, CC / Q000032:analysis* / Q000235:genetics; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D018946:Chemokine CCL5; D019742:Chemokines, CC