title: Renal injury from valproic acid: case report and literature review.
abstract: A child with developmental delay and epilepsy developed glucosuria approximately 16 months after starting valproic acid therapy. Laboratory evaluation revealed global defects in proximal tubule function consistent with the De Toni-Debré-Fanconi syndrome. Discontinuation of valproate led to complete recovery 5 months later. Review of previously reported cases indicates that this complication is unique to children and reversible when the medication is discontinued.
authors.affiliation: Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo and The Children's Hospital, Buffalo, New York 14222, USA.
authors.forename: Emad L
authors.initials: EL
authors.lastname: Zaki
authors.forename: James E
authors.initials: JE
authors.lastname: Springate
mesh_terms: D002648:Child; D004832:Epilepsy, Absence / Q000188:drug therapy; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D014635:Valproic Acid