title: [Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro].
abstract: OBJECTIVE
  To study the effects of azone on the percutaneous absorption of baicalin in vitro.
  
  
  METHODS
  Using the skin of nude mice as the cutaneous barrier, the rate constants of percutaneous absorption of baicalin at various concentrations of Azone were determined.
  
  
  RESULTS
  The rate constants were 76.07, 89.23, 167.36, 238.61, 200.45 and 171.49 microgram cm-2.h-1 respectively corresponding to the concentrations of Azone at 0, 2%, 4%, 6%, 8%, and 10%.
  
  
  CONCLUSIONS
  C Azone can enhance percutaneous absorption of baicalin, exerting its maximum effect at the concentration of 6%.
authors.affiliation: Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China.
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: L
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Lu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001381:Azepines / Q000494:pharmacology*; D004347:Drug Interactions; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D023421:Models, Animal; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D001381:Azepines; D005419:Flavonoids; C035229:laurocapram; C038044:baicalin