The radical scavenging effects of stilbene glucosides from Polygonum multiflorum.
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 microM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 microM).
Ryu
Geonseek
G
Regional Research Center and Department of Chemical Technology, Hanbat National University, Yusung-ku, Daejon, Korea.
Ju
Jeung Hoon
JH
Park
Yong Ju
YJ
Ryu
Shi Yong
SY
Choi
Byoung Wook
BW
Lee
Bong Ho
BH
D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D028502:Polygonum / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification
D016166:Free Radical Scavengers; D005960:Glucosides; D010936:Plant Extracts; D013267:Stilbenes