Effect of chronic administration of imipramine on 2A-serotonin receptor mRNA in brain cortex of rats predisposed and resistant to catalepsy.
Rats selected by predisposition to catalepsy showed decreased level of 2A-serotonin receptor mRNA in the frontal cortex in comparison with Wistar rats (p<0.05). Chronic administration of tricyclic antidepressant imipramine hydrochloride 2-fold increased the content of receptor mRNA in genetically cataleptic rats (p<0.001) and did not change this parameter in Wistar rats. These results prompted us to revise current notion on the mechanisms of chronic effect of imipramine on 2A-serotonin receptors.
Kulikov
A V
AV
Laboratory of Behaviour Phenogenetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. kulikov@bionet.nsc.ru
Tikhonova
M A
MA
Barykina
N N
NN
Alekhina
T A
TA
Chugui
V F
VF
Kolpakov
V G
VG
Popova
N K
NK
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000494:pharmacology*; D001483:Base Sequence; D002375:Catalepsy / Q000235:genetics*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*
D000929:Antidepressive Agents, Tricyclic; D017931:DNA Primers; D012333:RNA, Messenger; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D007099:Imipramine