[Multielectrode mapping study of proarrhythmic vagal effects in the dog atria].
Epicardial mapping (254 unipolar electrodes) of the dog heart both atria was performed to determine spatial distribution of arrhythmic events. The mapping showed that the first atrial premature depolarisation (APD) emerged from ectopic foci, it showed also specific multifocal patterns suggesting a septal source of tachycardia. The data obtained suggests that vagal stimulation (VS) induces focal ectopic APDs, that APDs and escape beats may be due to the same mechanism of spontaneous depolarization in the absence of a reset from dominant rhythm, that a single VS-induced APD is sufficient for initiation of a reentrant atrial fibrillation.
Zaítsev
A V
AV
Rozenshtraukh
L V
LV
Sharifov
O F
OF
Kaliadin
A Iu
AIu
Schuessler
R B
RB
Beloshapko
G G
GG
Iushmanova
A V
AV
Boineau
J P
JP
D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology*; D016275:Atrial Function / Q000502:physiology*; D004285:Dogs; D004558:Electric Stimulation; D004566:Electrodes; D022062:Electrophysiologic Techniques, Cardiac / Q000295:instrumentation* / Q000379:methods; D014630:Vagus Nerve / Q000502:physiology*