The origin of DNA replication and Fieller's problem.
The paper considers the statistical problem of estimating the origin of DNA replication within the human ribosomal DNA (rDNA) locus and the issue of assessing the standard error of the estimate. Based on mapping the cumulative replication index (CRI), two different modelling schemes are suggested and investigated. The statistical problem of constructing a confidence interval for the origin of DNA replication is related to Fieller's problem of obtaining a confidence interval for the ratio of two normal means. Standard normal theory, the delta and bootstrap methods are used to estimate the standard error of the estimate of the origin of DNA replication, as well as the variation of the replication rate.
Truong
Young K
YK
Department of Biostatistics, CB#7400, University of North Carolina, Chapel Hill, NC 27599-7400, USA. truong@bios.unc.edu
Scott
Rona S
RS
Vos
Jean-Michel H
JM
D002877:Chromosomes, Human / Q000235:genetics; D016001:Confidence Intervals; D004261:DNA Replication / Q000235:genetics*; D004275:DNA, Ribosomal / Q000235:genetics*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008957:Models, Genetic; D015233:Models, Statistical; D009716:Numerical Analysis, Computer-Assisted; D018741:Replication Origin / Q000235:genetics*; D016196:S Phase / Q000235:genetics
D004275:DNA, Ribosomal