title: Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants.
abstract: BACKGROUND
  Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the hormonal system (endocrine disrupters).
  
  
  METHODS
  Thirty obese individuals recruited for gastroplasty were compared before and after treatment with 45 normal-weight people.
  
  
  METHODS
  Blood samples were analyzed for DDT, DDE, HCB and PCBs no. 28, 52, 101, 118, 138, 153 and 180, by gas chromatography-mass spectrometry.
  
  
  RESULTS
  The results indicate clearly that body weight loss occurring after gastroplasty increases plasma concentration of lipophilic pollutants.
  
  
  CONCLUSIONS
  Gastroplasty increases plasma concentration of organochlorine pesticides and PCBs, which could be a risk factor of endocrine disruption. Future longitudinal research will have to determine if the advantages of body weight loss are reduced by this potentially harmful effect.
authors.affiliation: Clinical Toxicology Laboratory, University Hospital, Liege, Belgium. c.charlier@chu.ulg.ac.be
authors.forename: C
authors.initials: C
authors.lastname: Charlier
authors.forename: C l
authors.initials: Cl
authors.lastname: Desaive
authors.forename: G
authors.initials: G
authors.lastname: Plomteux
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D003634:DDT / Q000097:blood; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D004703:Endocrine System; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D015391:Gastroplasty / Q000009:adverse effects*; D015386:Hazardous Substances / Q000097:blood; D006801:Humans; D007306:Insecticides / Q000097:blood*; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D011078:Polychlorinated Biphenyls / Q000097:blood; D015431:Weight Loss
chemical_list: D015386:Hazardous Substances; D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene; D003634:DDT; D011078:Polychlorinated Biphenyls