title: Mycobacterium tuberculosis transmission between cluster members with similar fingerprint patterns.
abstract: Molecular epidemiologic studies provide evidence of transmission of Mycobacterium tuberculosis within clusters of patients whose isolates share identical IS6110-DNA fingerprint patterns. However, M. tuberculosis transmission among patients whose isolates have similar but not identical DNA fingerprint patterns (i.e., differing by a single band) has not been well documented. We used DNA fingerprinting, combined with conventional epidemiology, to show unsuspected patterns of tuberculosis transmission associated with three public bars in the same city. Among clustered TB cases, DNA fingerprinting analysis of isolates with similar and identical fingerprints helped us discover epidemiologic links missed during routine tuberculosis contact investigations.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: Kashef
authors.initials: K
authors.lastname: Ijaz
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Yang
authors.forename: H Stewart
authors.initials: HS
authors.lastname: Matthews
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Bates
authors.forename: M Donald
authors.initials: MD
authors.lastname: Cave
mesh_terms: D000328:Adult; D001131:Arkansas / Q000453:epidemiology; D016000:Cluster Analysis; D016358:Contact Tracing; D016172:DNA Fingerprinting; D006801:Humans; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics*; D012307:Risk Factors; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission*