The cytotoxic and antitumor activities of the imidazole alkaloid polycarpin from the ascidian Polycarpa aurata and its synthetic analogues.
Popov
A M
AM
Pacific Institute of Bioorganic Chemistry, Far East Division, Russian Academy of Sciences, pr. Stoletiya Vladivostoka 159, Vladivostok, 690022 Russia.
Novikov
V L
VL
Radchenko
O S
OS
Elyakov
G B
GB
D000470:Alkaloids / Q000494:pharmacology* / Q000633:toxicity*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000494:pharmacology* / Q000633:toxicity*; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy*; D013154:Spleen / Q000166:cytology; D013997:Time Factors; D014561:Urochordata
D000470:Alkaloids; D000970:Antineoplastic Agents; D007093:Imidazoles; C475052:polycarpine