Self-biting induced by activation of L-type calcium channels in mice: serotonergic influences.
The L-type calcium channel activator +/-Bay K 8644 has recently been shown to provoke self-injurious biting in young mice. Since the serotonergic systems have been implicated in the expression of self-injurious behavior in both humans and animals, the present studies tested whether drugs influencing serotonin systems could modify the ability of +/-Bay K 8644 to cause this behavior. The ability of +/-Bay K 8644 to provoke self-biting behavior was increased by the serotonin uptake inhibitor fluoxetine or the monoamine oxidase inhibitor clorgyline. On the other hand, the ability of +/-Bay K 8644 to provoke self-biting was decreased by depletion of serotonin with p-chlorophenylalanine or 5,7-dihyroxytryptamine. These results suggest that the ability of +/-Bay K 8644 to provoke self-injurious behaviors may be mediated by serotonergic influences.
Kasim
Suhail
S
Department of Neurology, Johns Hopkins Hospital, Baltimore, Md 21287, USA.
Egami
Kiyoshi
K
Jinnah
H A
HA
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000187:drug effects / Q000378:metabolism; D003010:Clorgyline / Q000494:pharmacology; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D012652:Self Mutilation / Q000139:chemically induced*; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D015116:5,7-Dihydroxytryptamine; D002120:Calcium Channel Agonists; D020746:Calcium Channels, L-Type; D003010:Clorgyline; D010134:Fenclonine; D005473:Fluoxetine; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors