Effects of dopamine and sodium nitroprusside on myocytes of regional arteries and veins during whole-body hypothermia and hypoxia.
In experiments on cats, dopamine induced constriction, while sodium nitroprusside dilation of arteries and veins perfused with a constant volume of autoblood in the decentralized gastrocnemius muscle and small intestine. Vascular responses to both test substances were reduced under the effect of hypothermia and especially under the effect of hypoxia alone. During combined exposure to hypoxia and hypothermia the decrease in the amplitude of vascular responses to dopamine and sodium nitroprusside was similar to that observed during hypoxia alone.
Kudryashov
Yu A
YA
Department of Physiology of Visceral System, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Tabarov
M S
MS
Tkachenko
B I
BI
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology; D002415:Cats; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D007035:Hypothermia; D000860:Hypoxia; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism; D009132:Muscles / Q000166:cytology* / Q000378:metabolism; D009599:Nitroprusside / Q000494:pharmacology*; D014680:Veins / Q000187:drug effects / Q000378:metabolism
D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D009599:Nitroprusside; D004298:Dopamine