Inflammatory demyelinating polyradiculoneuropathy associated with membranous glomerulonephritis and thrombocytopaenia.
A 66-year-old man with secondary progressive multiple sclerosis presented with a flaccid areflexic tetraparesis evolving over a 6-week period. Clinical examination and subsequent investigation confirmed a diagnosis of sub-acute inflammatory demyelinating polyradiculoneuropathy (sub-acute IDP). Nephrotic-range proteinuria and thrombocytopaenia were also noted at the time of presentation-histopathological investigation of the former showed membranous glomerulonephritis as the basis for the protein loss. The IDP, glomerulonephritis and thrombocytopaenia recovered over the same time course. There have been previous reports of either glomerulonephritis or thrombocytopaenia occurring in association with IDP-there are no such reports of all three conditions occurring and resolving simultaneously.
Emsley
Hedley C A
HC
University of Manchester and Hope Hospital, Salford, UK.
Molloy
Jane
J
D000368:Aged; D015433:Glomerulonephritis, Membranous / Q000150:complications*; D020275:Guillain-Barre Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D020528:Multiple Sclerosis, Chronic Progressive / Q000150:complications; D010291:Paresis / Q000209:etiology; D011507:Proteinuria / Q000150:complications; D013921:Thrombocytopenia / Q000150:complications*