Effects of dietary anthocyanins on tocopherols and lipids in rats.
The effects of dietary cyanidin-3-O-glucoside (C3G) and concentrates from blackcurrant [Ribes nigrum] (BC) and elderberry [Sambucus nigra] (EC) on plasma and tissue concentrations of alpha- (alpha-T) and gamma-tocopherol (gamma-T) and cholesterol, as well as the fatty acid composition of the liver lipids were investigated in growing, male rats of the Sprague-Dawley strain. Animals were fed semisynthetic diets supplemented with 2 g/kg C3G, BC, or EC for 4 weeks. Dietary anthocyanins did not affect feed intake, body weight, and organ weights. C3G elevated the concentrations of tocopherols in the liver and lungs (P < 0.05). Cholesterol levels in plasma and liver were not affected by any of the regimens. C3G and BC reduced the relative amount of saturated fatty acids in the liver (P < 0.05). BC also lowered the percentage of 22:6 + 24:0 and EC the ratio of 20:3/20:4 n-6 (P < 0.05). In conclusion, dietary C3G, BC, and EC appear to have little effect on cholesterol levels and the fatty acid pattern in the liver but seem to be capable of sparing vitamin E in healthy, growing rats.
Frank
Jan
J
Department of Food Science, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden. Jan.Frank@lmv.slu.se
Kamal-Eldin
Afaf
A
Lundh
Torbjörn
T
Määttä
Kaisu
K
Törrönen
Riitta
R
Vessby
Bengt
B
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D004032:Diet; D005227:Fatty Acids / Q000032:analysis; D005638:Fruit / Q000737:chemistry; D005960:Glucosides / Q000494:pharmacology; D008055:Lipids / Q000032:analysis* / Q000097:blood; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D031965:Ribes / Q000737:chemistry*; D027924:Sambucus nigra / Q000737:chemistry*; D024505:Tocopherols / Q000032:analysis* / Q000097:blood; D024502:alpha-Tocopherol / Q000032:analysis / Q000097:blood; D024504:gamma-Tocopherol / Q000032:analysis / Q000097:blood
D000872:Anthocyanins; D005227:Fatty Acids; D005960:Glucosides; D008055:Lipids; C462279:cyanidin-3-O-beta-glucopyranoside; D024504:gamma-Tocopherol; D002784:Cholesterol; D024502:alpha-Tocopherol; D024505:Tocopherols