[Changes in phosphoinositide metabolism in the brain of rats with different neuromuscular excitation threshold subjected to neurotic exposure and antioxidant administration].
No difference was found in metabolism of phosphoinositides in rats with high (H) and low (L) levels of excitability under normal conditions. Neurotisation decreased the content of phosphotidilinositol-4,5-diphosphate and increased the phosphorus turnover rate in the brain cortex of the L rats. Oxymetacyl reduced the effect of neurotisation. This antioxidants seems to exert an effect on the brain cells functional condition in the L rats.
Raĭze
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TE
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034 St. Petersburg, 6, Nab. Makarova, Russia.
Shiriaeva
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NV
Vaĭdo
A I
AI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001008:Anxiety Disorders / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D004597:Electroshock; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D010775:Photic Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000502:physiology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000975:Antioxidants; D010716:Phosphatidylinositols; D014498:Uracil; C003029:oxymethacil