Effect of melatonin on hyperlipidemic nephropathy under constant light exposure.
Studies have shown anti-hyperlipidemic actions of melatonin, with pharmacological doses inducing changes in cholesterol levels. This study was designed to evaluate the effect of melatonin on adriamycin-induced (25mg/kg b.w., i.p.) hyperlipidemia under constant light exposure. Melatonin was injected i.p. (1,000 microg/kg b.w./day). Triglycerides, total cholesterol, high-density lipoprotein cholesterol, light-density lipoprotein cholesterol, non-proteic nitrogen compounds (urea and creatinine levels), total protein in serum, proteins eliminated in the urine and melatonin levels in serum and kidney were determined. Results show a decrease in melatonin levels induced by both adriamycin and constant light. Likewise, adriamycin induced significant increases in triglycerides, total cholesterol and light-density lipoprotein cholesterol, and lowered high-density lipoprotein cholesterol levels. Constant light exposure also prompted an increase in LDL-c levels and a decrease in HDL-c values, and intensified the effects of adriamycin on these two lipoproteins. All changes induced by adriamycin and constant light were reverted toward normality by melatonin administration.
Túnez
L
L
Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Córdoba, Spain.
Muñoz
M C
MC
Feijoo-López
A L
AL
Valdvira
E
E
Bujalance-Arenas
L
L
Montilla
P
P
D000818:Animals; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004317:Doxorubicin / Q000009:adverse effects; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D008027:Light; D008075:Lipoproteins, HDL / Q000097:blood / Q000145:classification; D008077:Lipoproteins, LDL / Q000097:blood / Q000145:classification; D008297:Male; D008550:Melatonin / Q000378:metabolism / Q000494:pharmacology*; D011507:Proteinuria / Q000139:chemically induced / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D004317:Doxorubicin; D014508:Urea; D002784:Cholesterol; D003404:Creatinine; D008550:Melatonin