Alkaloids from the roots of Senecio macedonicus Griseb.
The new alkaloids 7-,9-diangeloylplatynecine (1) and 8-episarracine N-oxide (2), were isolated and identified from the roots of Senecio macedonicus. Another one, 8-epineosarracine was detected by GC/MS analyses of the crude alkaloid mixture. The cytotoxicity and biological activity of the alkaloids were tested on normal murine spleen lymphocytes and P3U1 mouse myeloma.
Christov
Veselin
V
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia. christov@orgchm.bas.bg
Mikhova
Bozhanka
B
Alexandrova
Radostina
R
Dimitrova
Daniela
D
Nikolova
Elena
E
Evstatieva
Liuba
L
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013154:Spleen / Q000276:immunology
D011763:Pyrrolizidine Alkaloids; C011104:sarracine