title: Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.
abstract: Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs. We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs. Our results have shown that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that garcinone E may be potentially useful for the treatment of certain types of cancer.
authors.affiliation: Department of Medical Research & Education, Veterans General Hospital, Taipei, ROC.
authors.forename: Chi-Kuan
authors.initials: CK
authors.lastname: Ho
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Huang
authors.forename: Chieh-Chih
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control; D002453:Cell Cycle / Q000187:drug effects*; D005638:Fruit; D029762:Garcinia mangostana; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014966:Xanthenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014966:Xanthenes; C470472:garcinone E