Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine.
Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro. One compound 6-methoxy-5,8 bis(4'-amino-1'-methylbutylamino)quinoline [P(1)] was found to have good gametocytocidal activity against Plasmodium yoelli infected mice at 10mg kg(-1) dose in vivo.
Dua
Virendra K
VK
Malaria Research Centre, Field Station, Sector III, BHEL, Ranipur, Hardwar-249 403, India. virendradua@hotmail.com
Sinha
Sukesh N
SN
Biswas
Sukla
S
Valecha
N
N
Puri
S K
SK
Sharma
V P
VP
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009033:Culicidae / Q000382:microbiology; D005854:Germ Cells / Q000187:drug effects; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D033661:Oocysts / Q000187:drug effects; D010084:Oxidation-Reduction; D010967:Plasmodium yoelii / Q000187:drug effects; D011319:Primaquine / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry
D000962:Antimalarials; D013431:Sulfates; D011319:Primaquine