Cutaneous sclerosing extramedullary hematopoietic tumor in chronic myelogenous leukemia.
BACKGROUND
Extramedullary hematopoiesis is a well-documented manifestation of chronic myeloproliferative disorders, most commonly seen in chronic idiopathic myelofibrosis (agnogenic myeloid metaplasia), but rarely in chronic myelogenous leukemia. It typically occurs in the spleen and liver, but has also been described in skin. Microscopically, foci of extramedullary hematopoiesis consist of erythroid and myeloid precursors intermixed with megakaryocytes. The megakaryocytes may elaborate fibrogenic cytokines, which induce proliferation of fibroblasts. The term 'sclerosing extramedullary hematopoietic tumor' has been applied to this latter entity and its resemblance to a fibrohistiocytic neoplasm has been noted.


METHODS
We report the case of a 66-year-old man, whose cutaneous sclerosing extramedullary hematopoietic tumor preceded the diagnosis of chronic myelogenous leukemia.
Lane
Joshua E
JE
Section of Dermatology, Department of Medicine, The Medical College of Georgia, Augusta 30912, USA.
Walker
Anna N
AN
Kulharya
Anita
A
Marzec
Tomasz
T
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002467:Cell Nucleus / Q000473:pathology; D015726:Giant Cells / Q000378:metabolism / Q000473:pathology; D006411:Hematopoiesis, Extramedullary / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D008297:Male; D012598:Sclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D012871:Skin Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D014841:von Willebrand Factor / Q000378:metabolism
D014408:Biomarkers, Tumor; D014841:von Willebrand Factor