Key role of succinate dehydrogenase in insulin-induced inactivation of protein tyrosine phosphatases.
We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an insulin-sensitive source of H(2)O(2)that acts as a physiological inhibitor of protein tyrosine phosphatases. Succinate dehydrogenase plays a key role in insulin-stimulated generation of H(2)O(2)and inactivation of liver protein tyrosine phosphatases.
Pomytkin
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IA
Department of General Pathology and Pathophysiology, Russian Medical Academy of Postgraduate Education, Russian Ministry of Health, Moscow. ipomytkin@mtu-net.ru
Kolesova
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OE
D000818:Animals; D006861:Hydrogen Peroxide / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008314:Malonates / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000187:drug effects / Q000378:metabolism*; D019802:Succinic Acid / Q000494:pharmacology
D007328:Insulin; D008314:Malonates; C030290:malonic acid; D019802:Succinic Acid; D006861:Hydrogen Peroxide; D013385:Succinate Dehydrogenase; D017027:Protein Tyrosine Phosphatases