Blast crisis of chronic myeloid leukemia: diagnosis prompted by T(8;9).
T(8;9) is a relatively new translocation that has been reported in a few patients with chronic myeloid leukemia (CML) but never in acute myeloid leukemia (AML). We report here a patient who presented with AML with t(8; 9). He lacked the Philadelphia chromosome but tested positive for the gene by the polymerase chain reaction method. This confirmed the diagnosis of CML with blast crisis, and appropriate treatment could be instituted
Borker
Anupama
A
Department of Pediatric Hematology/Oncology, LSU Health Sciences Center/Children's Hospital of New Orleans, 200 Henry Clay Avenue, New Orleans, LA 70118, USA.
Yu
Lolie
L
Ode
David
D
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001752:Blast Crisis / Q000175:diagnosis* / Q000235:genetics; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure*; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005005:Ethmoid Sinus / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D015465:Leukemia, Myeloid, Accelerated Phase / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000628:therapy; D008297:Male; D008578:Meninges / Q000473:pathology; D008942:Mitoxantrone / Q000008:administration & dosage; D012074:Remission Induction; D012445:Sacrococcygeal Region; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000473:pathology; D013866:Thioguanine / Q000008:administration & dosage; D014178:Translocation, Genetic
D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone; D016044:Fusion Proteins, bcr-abl; D013866:Thioguanine; D003630:Daunorubicin