title: Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze.
abstract: Cholecystokinin (CCK)-A receptor (AR) and B receptor (BR) share highly amino acid sequence homology and overlap in their tissue distribution. We examined the anxiety-related behavior of CCK-AR, CCK-BR, and CCK-ARBR gene knockout (-/-) mice in the elevated plus-maze. CCK-AR(-/-) mice showed a significantly higher frequency of open-arm entries than wild-type and CCK-BR(-/-) mice, whereas the percentage open-arm entry values in CCK-AR(-/-) mice did not differ from those in wild-type mice. Thus, this increased frequency in open-arm entries for CCK-AR(-/-) mice was interpreted to be due to an increase in locomotor activity, rather than to a reduction in anxiety. By contrast, CCK-BR(-/-) mice showed significantly lower percentage open-arm entry values and spent significantly less time in the open- arms than wild-type and CCK-AR(-/-) mice. We therefore conclude that a lack of CCK-BR increases the anxiety-related behavior of the mouse in the elevated plus- maze.
authors.affiliation: Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho Itabashiku, -l73-0015, Tokyo, Japan. miyasaka@tmig.or.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Satoru
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Minoru
authors.initials: M
authors.lastname: Ohta
authors.forename: Setsuko
authors.initials: S
authors.lastname: Kanai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Aki
authors.initials: A
authors.lastname: Nagata
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Matsui
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Noda
authors.forename: Soichi
authors.initials: S
authors.lastname: Takiguchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takata
authors.forename: Takako
authors.initials: T
authors.lastname: Kawanami
authors.forename: Akihiro
authors.initials: A
authors.lastname: Funakoshi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001522:Behavior, Animal; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000235:genetics / Q000502:physiology*
chemical_list: D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin