Immunobiochemical characteristics of IgG antibodies in myasthenia.
The abzyme activity of mAb35 and pQ1-209 was compared with that of normal rabbit IgG and serum IgG from patients with various forms of myasthenia. It was found that mAb35 and pQ1-209 and IgG from patients with myasthenia possess catalytic activity. IgG from myasthenia patients with thymomas possess creatine phosphokinase activity, which 2-fold surpassed the control.
Lantsova
V B
VB
Department of Neuromuscular Diseases, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Sepp
E K
EK
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D003402:Creatine Kinase / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000276:immunology*; D011817:Rabbits; D013945:Thymoma / Q000150:complications / Q000201:enzymology / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications / Q000201:enzymology / Q000276:immunology; D005723:gamma-Glutamyltransferase / Q000032:analysis
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D005723:gamma-Glutamyltransferase; D003402:Creatine Kinase