title: Antihepatitis B response to hepatitis B vaccine administered simultaneously with tetanus toxoid in nonresponder individuals.
abstract: In this prospective study, our aim was to test the effect of simultaneous administration of preS2 and S containing recombinant hepatitis B vaccine (S2SRHB) with tetanus toxoid (TT) to the individuals who did not respond after three doses of hepatitis B vaccine previously. There were three groups (healthy individuals, pregnant women, hemodialysis patients), each was divided into two subgroups as groups A and B. Group A received S2SRHB+TT and group B received only S2SRHB. We found that in groups receiving both vaccines, both seroconversion rate and antibody titer level were significantly higher (P<0.05). In conclusion, simultaneous administration of S2SRHB+TT is more effective than administration of S2SRHB alone.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Medical Faculty of Kadir Has University, Vefabey Sokak No 5, 80 810 Gayrettepe, Istanbul, Turkey. suhas@anet.net.tr
authors.forename: Emine
authors.initials: E
authors.lastname: Sönmez
authors.forename: Ali Suha
authors.initials: AS
authors.lastname: Sönmez
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Bayindir
authors.forename: Diler
authors.initials: D
authors.lastname: Coskun
authors.forename: Sedat
authors.initials: S
authors.lastname: Aritürk
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology*; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D017325:Hepatitis B Vaccines; D013745:Tetanus Toxoid; D017778:Vaccines, Combined; D014614:Vaccines, Synthetic