title: Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.
abstract: Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.
authors.affiliation: Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Vollmer
authors.forename: Alexander
authors.initials: A
authors.lastname: Tomasz
mesh_terms: D000581:Amidohydrolases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001426:Bacterial Proteins; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009113:Muramidase / Q000378:metabolism; D009154:Mutation; D011008:Pneumococcal Infections / Q000382:microbiology / Q000503:physiopathology; D013296:Streptococcus pneumoniae / Q000201:enzymology* / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D009113:Muramidase; D000581:Amidohydrolases; C411846:pgdA protein, Streptococcus pneumoniae