title: Identification of a new HLA-DRB1 allele, DRB1*0321.
abstract: This communication reports the identification of a new HLA-DRB1*03 allele identified in three members of a Caucasian French family. This new allele has been officially named HLA-DRB1*0321 by the World Health Organization Nomenclature Committee. The complete exon 2 sequence of DRB1*0321 is identical to that of DRB1*0307 except for the first and second nucleotides of codon 37 (TT replacing AA), which lead to the substitution of a tyrosine for a phenylalanine (AAC-->TTC at position 37). The family study showed that this new allele was transmitted into the HLA-A*0101/09, -B*0801/14, -Cw*0701, -DRB1*0321, -DRB3*0101, -DQB1*0503 and -DPB1*0401 haplotype. The complete exon 2 sequence of this new allele has been previously deposited in the EMBL Sequence Database under accession number AF297266.
authors.affiliation: Laboratoire d'Immunogénétique et d'Histocompatibilité, EFS Pays de Loire, Nantes cedex, France.
authors.forename: K
authors.initials: K
authors.lastname: Gagne
authors.forename: F
authors.initials: F
authors.lastname: Bonneville
authors.forename: M-L
authors.initials: ML
authors.lastname: Cheneau
authors.forename: P
authors.initials: P
authors.lastname: Herry
authors.forename: M-J
authors.initials: MJ
authors.lastname: Pinson
authors.forename: P
authors.initials: P
authors.lastname: Herfray
authors.forename: A
authors.initials: A
authors.lastname: Cesbron-Gautier
authors.forename: G
authors.initials: G
authors.lastname: Folléa
authors.forename: J-D
authors.initials: JD
authors.lastname: Bignon
mesh_terms: D000483:Alleles; D001483:Base Sequence; D016026:Bone Marrow Transplantation / Q000276:immunology; D005091:Exons / Q000235:genetics; D005192:Family Health; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains