Comparison of the efficacy of cell preparations from embryonic ventral mesencephalon of various prenatal age transplanted intrastriatally to rats with 6-OHDA-induced Parkinsonism.
Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis of apomorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy of cell preparations from 8- and lower from 16-17-day-old embryos. These data correlated with histomorphological findings, in particular, with the size of grafts, glial reaction, and the number of dopaminergic neurons in the grafts.
Chekhonin
V P
VP
V. P. Serbskii State Research Center of Social and Forensic Psychiatry, Moscow.
Lebedev
S V
SV
Dmitrieva
T B
TB
Blinov
D V
DV
Lazarenko
I P
IP
Savchenko
E A
EA
Volodin
N N
NN
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D016380:Brain Tissue Transplantation; D004298:Dopamine / Q000378:metabolism; D016332:Fetal Tissue Transplantation; D008297:Male; D008636:Mesencephalon / Q000196:embryology / Q000637:transplantation; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar
D016627:Oxidopamine; D001058:Apomorphine; D004298:Dopamine