title: Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models.
abstract: Studies have demonstrated neuronal expression of class I major histocompatibility complex (MHC) mRNA and protein in normal and developing brain and in response to injury or viral infection. We report neuronal expression of class I MHC mRNA in hypothalamic paraventricular nucleus (PVN) neurons in rats following systemic infection with Trypanosoma brucei brucei parasites (chronic) and in response to intravenous 1 mg/kg lipopolysaccharide administration (acute peripheral) and in striatal neurons following intrastriatal 5 microg lipopolysaccharide injection (acute central). These results demonstrate that neurons can be a source of immune signaling molecules and establish class I MHC as part of the neuronal component of immune responses.
authors.affiliation: Section on Functional Neuroanatomy, National Institute of Mental Health, 36 Convent Drive, Building 36, Room 2D15, Bethesda, MD 20892-4070, USA.
authors.forename: Jane A
authors.initials: JA
authors.lastname: Foster
authors.forename: Ning
authors.initials: N
authors.lastname: Quan
authors.forename: Edra L
authors.initials: EL
authors.lastname: Stern
authors.forename: Krister
authors.initials: K
authors.lastname: Kristensson
authors.forename: Miles
authors.initials: M
authors.lastname: Herkenham
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D005786:Gene Expression Regulation; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000235:genetics*; D017403:In Situ Hybridization; D007249:Inflammation / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D007700:Kinetics; D008070:Lipopolysaccharides; D008297:Male; D015213:Neuroimmunomodulation; D009474:Neurons / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014158:Transcription, Genetic; D014352:Trypanosomiasis / Q000235:genetics / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D008070:Lipopolysaccharides; D012333:RNA, Messenger