[Antioxidant activity of the hepatoprotector maxar in experimental diabetes].
Maxar, a hepatoprotector of plant origin containing polyphenols, exhibits an antioxidant effect in animals with alloxane-induced diabetes. The administration of maxar reduces the intensity of lipid peroxidation (LPO) and normalizes the level of LPO products (diene conjugates, malonic dialdehyde, Schiff bases) in liver. The drug produces regulation of the protective antioxidant system primarily by increasing the level of endogenous antioxidants via activation of the glutathione-dependent enzymatic mechanisms and detoxication of lipid hydroperoxide radicals.
Ian'kova
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VI
Vladivostok Department of the Far-Eastern Scientific Center of Breathing Physiology and Pathology, Russian Academy of Medical Sciences, Institute of Medical Climatology and Restorative Therapy, ul. Russkaya 17b, Vladivostok, 690039 Russia.
Ivanova
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IL
Fedoreev
S A
SA
Kulesh
N I
NI
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols