title: Generalized eruptive keratoacanthoma of Grzybowski: follow-up of the original description and 50-year retrospect.
abstract: We report a follow-up of the original case of eruptive multiple keratoacanthoma (KA) described by Grzybowski in 1950 which did not show malignant transformation within 16 years after the onset of the disease in spite of a very widespread cutaneous involvement. There was no associated internal malignancy or any systemic disease either, and the patient died of a myocardial infarction unrelated to his cutaneous disorder. This case followed up for such a long time provides further confirmation that this variety of KA does not show invasive growth and usually does not progress into squamous cell carcinoma.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Schwartz
authors.forename: Maria
authors.initials: M
authors.lastname: Błaszczyk
authors.forename: Stefania
authors.initials: S
authors.lastname: Jablonska
mesh_terms: D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007636:Keratoacanthoma / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D008991:Monitoring, Physiologic; D012075:Remission, Spontaneous; D018570:Risk Assessment; D012536:Scalp Dermatoses / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology* / Q000503:physiopathology; D012878:Skin Neoplasms / Q000473:pathology; D013997:Time Factors