title: Selenium status in psoriasis and its relationship with alcohol consumption.
abstract: The aim of the study was to examine the influence of alcohol consumption on the severity of psoriasis and selenium (Se) concentration and Se-dependent gluathione peroxidase activity in plasma (pl-GSH-Px) and in erythrocytes (RBC-GSH-Px) in psoriatic patients. Thirty-five in-patients with psoriasis lasting <10 mo and 42 with psoriasis lasting >3 yr constituted groups 1 and 2, respectively. The severity of psoriasis was assessed using the PASI scoring system and the consumption of alcohol, using a structured questionnaire. The Se concentration was 47.11+/-11.61 microg/L in group 1 and 38.69+/-13.22 microg/L in group 2 (p<0.05), the pl-GSH-Px was 0.15+/-0.04 U/mL and 0.14+/-0.04 U/mL (p>0.05), and the RBC-GSH-Px was 13.97+/-4.27 U/g Hb and 13.16+/-3.85 U/g Hb (p>0.05), respectively. In excessive drinkers (<10% of patients, all males), the Se concentration was 32.84+/-10.88 microg/L, the pl-GSH-Px was 0.15+/-0.03 U/mL, and the RBC-GSH-Px was 11.64+/-3.32 U/g Hb. A low RBC-GSH-Px correlated to the consumption of high-grade alcoholic beverages (R=-0.45, p<0.05) and to the PASI value (R=-0.37, p<0.05) in group 2. Depressed Se concentration and Se-dependent GSH-Px can be related to the severity and a duration of psoriasis. The excessive consumption of alcohol is associated with severity of the disease and with low activity of GSH-Px in erythrocytes in patients with long-lasting psoriasis.
authors.affiliation: Department of Dermatology and Venereology, Medical Academy, Bialystok, Poland.
authors.forename: Agnieszka Beata
authors.initials: AB
authors.lastname: Serwin
authors.forename: Wojciech
authors.initials: W
authors.lastname: Waşowicz
authors.forename: Jolanta
authors.initials: J
authors.lastname: Gromadzińska
authors.forename: Bozena
authors.initials: B
authors.lastname: Chodynicka
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000473:pathology*; D012643:Selenium / Q000097:blood*
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium