[Gemcitabine-based combinations in inoperable pancreatic cancers].
Gemcitabine administered as a weekly 1,000 mg/m2 30 minutes infusion is considered as the standard treatment of non resectable pancreatic adenocarcinoma. However, the limited results obtained with this standard therapy justify gemcitabine-based combinations studies. We summarize the results of studies combining gemcitabine with 5FU, docetaxel, platinum-compounds, irinotecan and epirubicin. Some combinations seem to achieve an interesting efficacy, and are now compared to gemcitabine alone.
Louvet
Christophe
C
Service d'oncologie, médecine interne, Hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris. christophe.louvet@sat.ap-hop-paris.fr
André
Thierry
T
Artru
Pascal
P
D000230:Adenocarcinoma / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000069287:Capecitabine; D002945:Cisplatin / Q000627:therapeutic use; D017322:Clinical Trials, Phase II as Topic; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077143:Docetaxel; D004333:Drug Administration Routes; D015251:Epirubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D000077146:Irinotecan; D015337:Multicenter Studies as Topic; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D043823:Taxoids; D016896:Treatment Outcome; D000093542:Gemcitabine
D009944:Organoplatinum Compounds; D043823:Taxoids; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000077143:Docetaxel; D015251:Epirubicin; D000069287:Capecitabine; D000077146:Irinotecan; D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil; D002166:Camptothecin; D000093542:Gemcitabine