Management of sarcomas of the head and neck in adults.
Sarcomas account for less than 1% of all malignant neoplasms occurring in the head and neck in adults. These tumors exhibit variable growth and degrees of aggressiveness which are primarily dependent on histologic grade. The pattern of growth demonstrated by sarcomas is generally by local advancement with high-grade tumor exhibiting extensive involvement of adjacent visceral and neurovascular structures. Regional metastasis is uncommon. Etiologic considerations include the tumorigenic effects of prior external beam radiotherapy and the development of second malignancies in the form of sarcomas. The clinical presentation of these neoplasms is variable and dependent on subsite of involvement as well as the aggressiveness of tumor growth. Histologic diagnosis is frequently challenging, often requiring the aid of immunohistochemical staining techniques. Treatment is predominantly surgical, utilizing wide local excision where en-bloc resection is feasible. Radiotherapy, by means of external beam or implant, plays an important adjunctive role in management, especially for tumors where en-bloc resection with margin control is not possible. Chemotherapy regimens are available for soft tissue neoplasms and osteosarcoma and are primarily designed to improve local control. Survival is predicted on the incidence of local recurrence and risk of distant metastasis, both of which are influenced by tumor grade. Low-grade tumors exhibit improved survival over that of less differentiated tumors.
Pellitteri
Phillip K
PK
Department of Otolaryngology--Head and Neck Surgery, Geisinger Medical Center, Danville, Pennsylvania, USA.
Ferlito
Alfio
A
Bradley
Patrick J
PJ
Shaha
Ashok R
AR
Rinaldo
Alessandra
A
D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D012509:Sarcoma / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery; D016019:Survival Analysis; D016896:Treatment Outcome