title: Blast crisis of chronic myeloid leukemia: diagnosis prompted by T(8;9).
abstract: T(8;9) is a relatively new translocation that has been reported in a few patients with chronic myeloid leukemia (CML) but never in acute myeloid leukemia (AML). We report here a patient who presented with AML with t(8; 9). He lacked the Philadelphia chromosome but tested positive for the gene by the polymerase chain reaction method. This confirmed the diagnosis of CML with blast crisis, and appropriate treatment could be instituted
authors.affiliation: Department of Pediatric Hematology/Oncology, LSU Health Sciences Center/Children's Hospital of New Orleans, 200 Henry Clay Avenue, New Orleans, LA 70118, USA.
authors.forename: Anupama
authors.initials: A
authors.lastname: Borker
authors.forename: Lolie
authors.initials: L
authors.lastname: Yu
authors.forename: David
authors.initials: D
authors.lastname: Ode
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001752:Blast Crisis / Q000175:diagnosis* / Q000235:genetics; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure*; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005005:Ethmoid Sinus / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D015465:Leukemia, Myeloid, Accelerated Phase / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000628:therapy; D008297:Male; D008578:Meninges / Q000473:pathology; D008942:Mitoxantrone / Q000008:administration & dosage; D012074:Remission Induction; D012445:Sacrococcygeal Region; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000473:pathology; D013866:Thioguanine / Q000008:administration & dosage; D014178:Translocation, Genetic
chemical_list: D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone; D016044:Fusion Proteins, bcr-abl; D013866:Thioguanine; D003630:Daunorubicin