title: [Localization of positive surgical margins after retropubic, perineal and laparoscopic radical prostatectomy].
abstract: OBJECTIVE
  To study the sites of positive surgical margins after radical prostatectomy according to the technique used: retropubic, perineal or laparoscopic.
  
  
  METHODS
  538 radical prostatectomies were performed between 1988 and 2001: 184 via a retropubic approach, 119 via a perineal approach and 235 by laparoscopy. Clinical examination, PSA assay (Hybritech, Normal < 4 ng/ml) and transrectal biopsies were performed in all patients. The radical prostatectomy specimen was examined by the same pathologist according to the Stanford protocol. The frequency and site of positive surgical margins were studied as a function of pathological stage.
  
  
  RESULTS
  The positive surgical margins rate was 32%, 18.5% and 26.4% for the retropubic, perineal and laparoscopic techniques, respectively. The most frequent site of positive surgical margins was the apex for retropubic (41.1%) and perineal (41.6%) prostatectomy and the posterolateral part of the prostate for laparoscopic prostatectomy (41.9%). The most frequent site of positive surgical margins in pT2 tumours was the apex for the retropubic approach (50%), the base of the prostate (bladder neck) for the perineal approach (41.6%) and the apex and posterolateral part of the prostate for the laparoscopic approach (44.4% and 41.6%).
  
  
  CONCLUSIONS
  Each radical prostatectomy technique corresponds to a preferential site of positive surgical margins: the apex for the retropubic approach, the bladder neck for the perineal approach and the posterolateral part of the prostate for the laparoscopic approach.
authors.affiliation: Service d'Urologie, Hôpital Henri Mondor, 51, avenue du Maréchal de Lattre de Tassigny, 94000 Créteil. laurent.salomon@hmn.ap-hop-paris.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Salomon
authors.forename: Olivier
authors.initials: O
authors.lastname: Levrel
authors.forename: Alexandre
authors.initials: A
authors.lastname: de la Taille
authors.forename: Andras
authors.initials: A
authors.lastname: Hoznek
authors.forename: Dominique
authors.initials: D
authors.lastname: Chopin
authors.forename: Clément-Claude
authors.initials: CC
authors.lastname: Abbou
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen