title: Soft tissue response of the rabbit larynx to Gore-Tex implants.
abstract: The use of Gore-Tex (expanded polytetrafluoroethylene) for medialization laryngoplasty has recently been described. Clinically, this laryngeal implant has performed well, but no animal studies evaluating the use of this implant in the larynx have been published. This study examines the gross and histologic response of the rabbit larynx to the Gore-Tex implant. Five rabbits underwent bilateral medialization with the Gore Thyroplasty Device. The vocal folds were left innervated and mobile. After 6 months, the rabbits were painlessly sacrificed and the implants were evaluated by gross inspection and histologic examination. No gross changes to the glottis occurred, and the implants were easily removed with gentle traction. A modest inflammatory response with a thin fibrous capsule was present around the implant. Foreign body giant cells were observed at the interface of the implant with the tissue. No migration or extrusion of the implant was observed. These results suggest that Gore-Tex is biocompatible in the rabbit larynx.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7777, USA.
authors.forename: Steve
authors.initials: S
authors.lastname: Cashman
authors.forename: C Blake
authors.initials: CB
authors.lastname: Simpson
authors.forename: H Stan
authors.initials: HS
authors.lastname: McGuff
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D005549:Foreign-Body Reaction / Q000473:pathology; D020007:Implants, Experimental / Q000009:adverse effects; D007249:Inflammation / Q000473:pathology; D007830:Larynx / Q000473:pathology / Q000601:surgery*; D011138:Polytetrafluoroethylene; D011817:Rabbits; D013997:Time Factors; D014826:Vocal Cord Paralysis / Q000601:surgery*; D014827:Vocal Cords / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D011138:Polytetrafluoroethylene