Molecular approaches to the study of Coccidioides immitis.
The study of the molecular biology of Coccidioides sp. is only just beginning. As the importance of coccidioidomycosis grows as a public health problem, our need for understanding of pathogenesis, immune responses, and improved antifungal therapy also increases in proportion. Tools have now become available to study gene manipulation in this pathogen and this will allow molecular approaches to be used. Genetic experiments will also be accelerated by the availability of the whole coccidioidal genome, expected to be made public in the spring of 2003 (see http://www.tigr.org/tdb/tgi/cigi/GenInfo.html). Thus, there seems to be several reasons to expect considerable progress in the coming years.
Abuodeh
Raed O
RO
University of Sharjah, College of Health Sciences, Sharjah, United Arab Emirates. abuodeh@sharjah.ac.ae
Galgiani
John N
JN
Scalarone
Gene M
GM
D000818:Animals; D003045:Coccidioides / Q000235:genetics* / Q000276:immunology; D003047:Coccidioidomycosis / Q000188:drug therapy; D005657:Fungal Vaccines / Q000235:genetics / Q000627:therapeutic use; D005800:Genes, Fungal / Q000235:genetics; D016681:Genome, Fungal; D006801:Humans; D012988:Soil Microbiology
D005657:Fungal Vaccines