[Bullous pemphigoid, primary biliary cirrhosis and vitiligo: a multiple autoimmune syndrome?].
Bullous pemphigoid is the most frequent autoimmune blistering skin disease. There have been few reports of an association with primary biliary cirrhosis and vitiligo. We report the simultaneous occurrence of bullous pemphigoid and primary biliary cirrhosis in an 86-year-old patient who also suffered from vitiligo. Multiple autoimmune syndrome, proposed by Humbert and Dupond, can be divided into three groups based on preferential associations of autoimmune disorders. The association of bullous pemphigoid, cirrhosis biliary primary and vitiligo has been reported three times in the literature. This association is probably not fortuitous and suggests a pathogenic relationship. This association is not typical of the multiple autoimmune syndrome as defined by Humbert and Dupond but the collection of such observations may contribute to revise the classification of autoimmune disease and provide a better understanding of the pathophysiological mechanisms of autoimmunity.
Marcet
Benjamin
B
Service de Dermatologie, Hôpital Saint-André, CHU de -Bordeaux, 33075 Bordeaux Cedex, France.
Sibaud
Vincent
V
Géniaux
Marc
M
Taieb
Alain
A
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis; D010391:Pemphigoid, Bullous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D013577:Syndrome; D016896:Treatment Outcome; D014820:Vitiligo / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology
D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D001379:Azathioprine