The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid.
Thyroid-stimulating hormone, TSH, of the anterior pituitary gland is regulated by the binding of the thyroid hormone-activated thyroid receptor to the TSH gene at the same time as the binding of the 9-cis-retinoic acid-activated retinoid X receptor to the same gene. Both interactions, separately or simultaneously, can suppress and thus regulate the expression of the TSH gene.
Wolf
George
G
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720-3104, USA.
D000077556:Alitretinoin; D000818:Animals; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism*; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000502:physiology; D011988:Receptors, Thyroid Hormone / Q000187:drug effects / Q000502:physiology; D047488:Retinoid X Receptors; D013963:Thyroid Hormones / Q000097:blood / Q000494:pharmacology*; D013972:Thyrotropin / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014212:Tretinoin / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood / Q000494:pharmacology
D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; D047488:Retinoid X Receptors; D013963:Thyroid Hormones; D014157:Transcription Factors; D014284:Triiodothyronine; D000077556:Alitretinoin; D014212:Tretinoin; D013972:Thyrotropin; D013974:Thyroxine