Familial cluster headache: a series of 186 index patients.
OBJECTIVE
To investigate the familial occurrence of cluster headache in a series of French patients fulfilling the International Headache Society diagnosis criteria.


METHODS
One hundred eighty-six index patients and 624 first-degree relatives were surveyed.


RESULTS
A positive family history of cluster headache was found in 20 index patients (10.75%) with 22 affected first-degree relatives (3.4%). In multiplex families 6 of the 68 second-degree relatives that were contacted had cluster headache.


CONCLUSIONS
No precise mode of inheritance could be drawn from the observed repartition of cases within multiplex families.
El Amrani
Mohammed
M
Service de Neurologie, Clinique de Courlancy, Reims, France. mohammed.el-amrani@lrb.ap-hop-paris.fr
Ducros
Anne
A
Boulan
Pauline
P
Aidi
Saadia
S
Crassard
Isabelle
I
Visy
Jean Marc
JM
Tournier-Lasserve
Elisabeth
E
Bousser
Marie Germaine
MG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003027:Cluster Headache / Q000453:epidemiology* / Q000235:genetics*; D005192:Family Health; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D017678:Sex Distribution