title: [Endocrine function of the thymus in experimental hypothyroidism].
abstract: An Endocrine function of the thymus was studied by analyzing the level of thymulin in rats in 1-6 months after extirpation of the thymus. The level of thymulin in rats after thyroidectomy has been shown to be reduced maximally in 6 months after an operation. An inhibitor of thymulin was detected in the blood serum in a month after extirpation, then it disappeared completely from it. After thyroidectomy the mass of animals decreased, as well as an absolute and relative mass of the thymus and its cellular content. Thyroidectomy was followed with a marked decrease in the thyroid hormones content in the blood serum and a reduce in the adrenal cortex, especially at a distant period following an operation. The data obtained evidence that it is sensible to use the agents of the thymic origin to restore the hormone balance at hypothyroidism, together with the substitute therapy.
authors.affiliation: Oncology Institute Acad. Med. Sci., Kiev, Ukraine.
authors.forename: Iu Ia
authors.initials: IuIa
authors.lastname: Hrynevych
authors.forename: H D
authors.initials: HD
authors.lastname: Bendiuh
authors.forename: L H
authors.initials: LH
authors.lastname: Iuhrinova
authors.forename: T N
authors.initials: TN
authors.lastname: Selezn'ova
mesh_terms: D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D007037:Hypothyroidism / Q000503:physiopathology*; D008297:Male; D009929:Organ Size; D051381:Rats; D013935:Thymic Factor, Circulating / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood; D013965:Thyroidectomy
chemical_list: D013963:Thyroid Hormones; D013935:Thymic Factor, Circulating