title: Detection of spatial repolarization abnormalities in patients with LQT1 and LQT2 forms of congenital long-QT syndrome.
abstract: The aim of this study is to detect the spatial current dispersion that appears in the T-wave of patients with congenital long-QT syndrome (LQTS). To observe this dispersion, magnetocardiograms (MCGs)--which have a high spatial resolution--of LQT1 patients (n = 7), LQT2 patients (n = 9) and a control group (n = 33) were recorded. The dispersion was evaluated by plotting current-arrow maps (CAMs) calculated from the MCG signals. In the case of LQT1, abnormal current arrows in the CAMs appeared above the inferior part of the heart in two LQT1 patients with a long corrected QT interval (QTc) (>0.6), and the current direction was from the left (origin side) to the right ventricular muscle (110 degrees). In six out of nine LQT2 patients, abnormal current arrows with angles below 20 degrees were observed above the right inferior part or lower septum; the current direction was from the right (origin side) to the left ventricular muscle. However, in the case of the LQT2 patients, the QTc values did not correlate with the abnormal current. These findings suggest that the origin of abnormal repolarization in LQT1 is the left ventricular muscle and the origin of that in LQT2 is the right ventricular muscle or lower septum. The estimation of the origin in LQTS patients can provide important information such as the risk factor of sudden death.
authors.affiliation: Central Research Laboratory, Hitachi Ltd, 1-280 Higashi-Koigakubo, Kokubunji, Tokyo 185-8601, Japan. kandori@crl.hitachi.co.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kandori
authors.forename: Wataru
authors.initials: W
authors.lastname: Shimizu
authors.forename: Miki
authors.initials: M
authors.lastname: Yokokawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Maruo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kanzaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakatani
authors.forename: Shiro
authors.initials: S
authors.lastname: Kamakura
authors.forename: Kunio
authors.initials: K
authors.lastname: Miyatake
authors.forename: Masahiro
authors.initials: M
authors.lastname: Murakami
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyashita
authors.forename: Kuniomi
authors.initials: K
authors.lastname: Ogata
authors.forename: Keiji
authors.initials: K
authors.lastname: Tsukada
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D029597:Romano-Ward Syndrome / Q000175:diagnosis* / Q000503:physiopathology*