[The mitochondrial organelle and the heart].
The heart is highly dependent for its function on oxidative energy generated in mitochondria, primarily by fatty acid beta-oxidation, respiratory electron chain and oxidative phosphorylation. Defects in mitochondrial structure and function have been found in association with cardiovascular diseases such as dilated and hypertrophy cardiomyopathy, cardiac conduction defects and sudden death, ischemic and alcoholic cardiomyopathy, as well as myocarditis. While a subset of these mitochondrial abnormalities have a defined genetic basis (e.g. mitochondrial DNA changes leading to oxidative phosphorylation dysfunction,fatty acid beta-oxidation defects due to specific nuclear DNA mutations), other abnormalities appear to be due to a more sporadic or environmental cardiotoxic insult or have not yet been characterized.This review focuses on abnormalities in mitochondrial bioenergetic function and mitochondrial DNA defects associated with cardiovascular diseases, their significance in cardiac pathogenesis as well as on the available diagnostic and therapeutic options. A concise background concerning mitochondrial biogenesis and bioenergetic pathways during cardiac growth,development and aging will also be provided.
Marín-García
José
J
The Molecular Cardiology and Neuromuscular Institute. Highland Park, NJ 08904, USA. tmci@att.net
Goldenthal
Michael J
MJ
D000818:Animals; D017209:Apoptosis; D002311:Cardiomyopathy, Dilated / Q000378:metabolism / Q000473:pathology; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism / Q000473:pathology; D004272:DNA, Mitochondrial / Q000378:metabolism; D015316:Genetic Therapy; D006801:Humans; D051379:Mice; D008929:Mitochondria, Heart / Q000378:metabolism / Q000473:pathology*; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology
D004272:DNA, Mitochondrial