title: Cerebral hemorrhage associated with vitamin K deficiency in congenital tuberculosis treated with isoniazid and rifampin.
abstract: We report a male infant with congenital tuberculosis who developed cerebral hemorrhage associated with vitamin K deficiency during treatment with isoniazid and rifampin. Despite an absence of risk factors for vitamin K deficiency, the severe hemorrhagic disorder occurred at 4 months of age. We speculate that vitamin K deficiency in the present case may have resulted from a synergic effect of antituberculosis agents and immaturity of vitamin K metabolism and/or its absorption.
authors.affiliation: Department of Pediatrics, Kobe City General Hospital, Japan.
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Haruta
authors.forename: Haruko
authors.initials: H
authors.lastname: Maeda
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubota
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Nishio
mesh_terms: D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000150:complications / Q000178:diet therapy; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D014376:Tuberculosis / Q000150:complications / Q000151:congenital* / Q000188:drug therapy*; D014812:Vitamin K / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000139:chemically induced* / Q000150:complications / Q000178:diet therapy
chemical_list: D014812:Vitamin K; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin