Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.
ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified. This study used QRT-PCR to quantitatively map the transcriptional expression profile of ACE 2 (and the two isoforms of ACE) in 72 human tissues. While confirming that ACE 2 expression is high in renal and cardiovascular tissues, the novel observation has been made that ACE 2 shows comparably high levels of expression in the gastrointestinal system, in particular in ileum, duodenum, jejunum, caecum and colon. Therefore, in probing the functional significance of this novel peptidase, some consideration should be given to a role in gastrointestinal physiology and pathophysiology.
Harmer
Dan
D
Pharmagene Laboratories Ltd., 2 Orchard Rd., Royston, Hertfordshire SG8 5HD, UK. dan.harmer@pharmagene.com
Gilbert
Maureen
M
Borman
Richard
R
Clark
Kenneth L
KL
D000085962:Angiotensin-Converting Enzyme 2; D002268:Carboxypeptidases / Q000096:biosynthesis / Q000235:genetics*; D004064:Digestive System / Q000201:enzymology; D020869:Gene Expression Profiling; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis / Q000235:genetics; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014018:Tissue Distribution; D014158:Transcription, Genetic
D020033:Protein Isoforms; D012333:RNA, Messenger; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2