title: Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles.
abstract: Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and the uptake of free fatty acid in muscle. Previous studies using transgenic mice showed that increased LPL leads to myopathies, but these results were controversial. To examine this hypothesis, we studied LPL transgenic rabbits, and our results refute the suggested role of LPL in the pathogenesis of myopathies.
authors.affiliation: Cardiovascular Disease Laboratory, Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305-8575, Japan.
authors.forename: Tomonari
authors.initials: T
authors.lastname: Koike
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wang
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Unoki
authors.forename: Jingyan
authors.initials: J
authors.lastname: Liang
authors.forename: Tomonaga
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Kitajima
authors.forename: Teruo
authors.initials: T
authors.lastname: Watanabe
authors.forename: Jianglin
authors.initials: J
authors.lastname: Fan
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006330:Heart Defects, Congenital / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000201:enzymology* / Q000235:genetics; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D015854:Up-Regulation / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D008071:Lipoprotein Lipase