title: The effect of local hematoma blocks on early fracture healing.
abstract: To test the effects of lidocaine and bupivacaine on early fracture healing, the tensile strength of five groups of femora from normal rats 14 and 35 days after production of a closed diaphyseal fracture were compared. Data indicate that, in experimental animals injected with local anesthetics at the fracture site, no measurable difference is noted in callus composition, tensile strength, or histological appearance during the early phases of fracture repair prior to callus remodeling.
authors.affiliation: Lafayette Bone and Joint Clinic, Lafayette, LA, USA.
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Henry
authors.forename: Mike
authors.initials: M
authors.lastname: Kenison
authors.forename: Catherine
authors.initials: C
authors.lastname: McVay
authors.forename: Rial
authors.initials: R
authors.lastname: Rolfe
authors.forename: Suzannie
authors.initials: S
authors.lastname: Graham
authors.forename: Jahan
authors.initials: J
authors.lastname: Rasty
authors.forename: James
authors.initials: J
authors.lastname: Slauterbeck
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Dabezies
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005264:Femoral Fractures / Q000188:drug therapy* / Q000601:surgery; D005592:Fracture Fixation / Q000009:adverse effects / Q000379:methods*; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D006406:Hematoma / Q000188:drug therapy* / Q000209:etiology; D015552:Injections, Intralesional; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D011336:Probability; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans; D012016:Reference Values; D012680:Sensitivity and Specificity; D013718:Tensile Strength; D016474:Weight-Bearing
chemical_list: D008012:Lidocaine; D002045:Bupivacaine