title: The TB structural genomics consortium: providing a structural foundation for drug discovery.
abstract: Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.
authors.affiliation: Bioscience Division, Mail Stop M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Celia W
authors.initials: CW
authors.lastname: Goulding
authors.forename: Marcin
authors.initials: M
authors.lastname: Apostol
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Anderson
authors.forename: Harindarpal S
authors.initials: HS
authors.lastname: Gill
authors.forename: Clare V
authors.initials: CV
authors.lastname: Smith
authors.forename: Mack R
authors.initials: MR
authors.lastname: Kuo
authors.forename: Jin Kuk
authors.initials: JK
authors.lastname: Yang
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Waldo
authors.forename: Se Won
authors.initials: SW
authors.lastname: Suh
authors.forename: Radha
authors.initials: R
authors.lastname: Chauhan
authors.forename: Avinash
authors.initials: A
authors.lastname: Kale
authors.forename: Nandita
authors.initials: N
authors.lastname: Bachhawat
authors.forename: Shekhar C
authors.initials: SC
authors.lastname: Mande
authors.forename: Jodie M
authors.initials: JM
authors.lastname: Johnston
authors.forename: J Shaun
authors.initials: JS
authors.lastname: Lott
authors.forename: Edward N
authors.initials: EN
authors.lastname: Baker
authors.forename: Vickery L
authors.initials: VL
authors.lastname: Arcus
authors.forename: David
authors.initials: D
authors.lastname: Leys
authors.forename: Kirsty J
authors.initials: KJ
authors.lastname: McLean
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Munro
authors.forename: Joel
authors.initials: J
authors.lastname: Berendzen
authors.forename: Vivek
authors.initials: V
authors.lastname: Sharma
authors.forename: Min S
authors.initials: MS
authors.lastname: Park
authors.forename: David
authors.initials: D
authors.lastname: Eisenberg
authors.forename: James
authors.initials: J
authors.lastname: Sacchettini
authors.forename: Tom
authors.initials: T
authors.lastname: Alber
authors.forename: Bernhard
authors.initials: B
authors.lastname: Rupp
authors.forename: William
authors.initials: W
authors.lastname: Jacobs
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Terwilliger
mesh_terms: D000217:Acyltransferases; D000446:Aldehyde-Lyases / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000737:chemistry*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D015195:Drug Design; D023281:Genomics; D005974:Glutamate-Ammonia Ligase / Q000737:chemistry; D008780:Methyltransferases / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000737:chemistry* / Q000187:drug effects*; D007296:Myo-Inositol-1-Phosphate Synthase / Q000737:chemistry; D010088:Oxidoreductases / Q000737:chemistry; D019704:Protein Disulfide-Isomerases / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; C085257:InhA protein, Mycobacterium; D008780:Methyltransferases; C019964:cyclopropane synthetase; D000217:Acyltransferases; C121433:antigen 85B, Mycobacterium tuberculosis; D000446:Aldehyde-Lyases; C020044:dihydroneopterin aldolase; D019704:Protein Disulfide-Isomerases; D007296:Myo-Inositol-1-Phosphate Synthase; D005974:Glutamate-Ammonia Ligase