title: Update on epidemiology and therapeutics for non-Hodgkin's lymphoma.
abstract: This chapter presents updated information on the trends and patterns of non-Hodgkin's lymphoma (NHL) diagnoses as well as new information on chemotherapeutic and immunotherapeutic options for NHL treatment. In Section I, Dr. Brian Chiu summarizes the current knowledge regarding the etiologic factors and patterns of NHL as well as suggests future epidemiologic studies based on these preliminary results. In Section II, Dr. Bruce Cheson and colleagues outline new chemotherapeutic and small molecule antineoplastic agents with unique mechanisms of action such as protease inhibitors, farnesyl transferase or histone deacetylase inhibitors, and antisense oligonucleotides. In Section III, Dr. Julie Vose reviews the anti-lymphoma effects of monoclonal antibodies, radioimmunoconjugates, idiotype vaccines, and immunologic enhancing adjuvants with respect to mechanisms of action, clinical trials, and their potential for patient therapy.
authors.affiliation: University of Nebraska Medical Center, Nebraska Medical Center, Omaha 68198, USA.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Vose
authors.forename: Brian C-H
authors.initials: BC
authors.lastname: Chiu
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Cheson
authors.forename: Janet
authors.initials: J
authors.lastname: Dancey
authors.forename: John
authors.initials: J
authors.lastname: Wright
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D016499:Radioimmunotherapy
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents