Resorbable posterolateral graft containment in a rabbit spinal fusion model.
OBJECTIVE
The authors studied the effect of a resorbable graft containment device in a rabbit posterolateral lumbar spinal fusion model.


METHODS
Twenty rabbits were divided into four groups: autologous bone graft (ABG), ABG with the MacroPore containment device (ABG + MP), demineralized bone matrix (DBM), and DBM with the containment device (DBM + MP). Fusion mass was assessed at 6 weeks with high-resolution radiography and volumetric computerized tomography. The graft containment device was associated with alteration of the fusion mass structure and significant enhancement of fusion mass volume (ABG versus ABG + MP, p = 0.027; DBM versus DBM + MP, p = 0.043).


CONCLUSIONS
A bioabsorbable protective graft containment device successfully enhanced posterolateral spinal fusion mass volume.
Poynton
Ashley R
AR
Department of Metabolic Bone Diseases and Orthopedic Surgery, Hospital for Special Surgery, New York, New York, USA.
Zheng
Fengyu
F
Tomin
Emre
E
Lane
Joseph M
JM
Cornwall
G Bryan
GB
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001857:Bone Matrix / Q000000981:diagnostic imaging / Q000187:drug effects / Q000601:surgery; D001861:Bone Regeneration / Q000187:drug effects; D004195:Disease Models, Animal; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000601:surgery*; D011091:Polyesters / Q000627:therapeutic use*; D011817:Rabbits; D013123:Spinal Fusion; D013124:Spinal Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)