Murine natural killer cell progenitors and their requirements for development.
Molecules that are essential to natural killer (NK) cell development have been identified mostly through characterizing knock-out mice that exhibit NK deficiencies. Such studies have shown that the interaction of membrane lymphotoxin (LT) on NK cells with its receptor on stromal elements is necessary for inducing a permissive microenvironment for NK development. Also, transcription factors such as Id2, interferon regulatory factors-1 (IRF-1), IRF-2, and Ets-1 are indispensable while PU.1 has a somewhat selective role. In addition, recent studies have identified T/NK progenitors (T/NKPs) in the fetal liver that precede migration to the fetal thymus as well as the earliest committed NK precursors in the bone marrow.
Lian
Rebecca H
RH
Department of Pathology, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA. rlian@bsd.uchicago.edu
Kumar
Vinay
V
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology; D018507:Gene Expression Regulation, Developmental; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D051797:Inhibitor of Differentiation Protein 2; D050856:Interferon Regulatory Factor-1; D050836:Interferon Regulatory Factor-2; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology; D008233:Lymphotoxin-alpha / Q000276:immunology; D051379:Mice; D010750:Phosphoproteins / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000276:immunology; D012097:Repressor Proteins; D015534:Trans-Activators / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology; D000099232:Proto-Oncogene Protein Spi-1
D004268:DNA-Binding Proteins; D051797:Inhibitor of Differentiation Protein 2; D050856:Interferon Regulatory Factor-1; D050836:Interferon Regulatory Factor-2; D008233:Lymphotoxin-alpha; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000099232:Proto-Oncogene Protein Spi-1; C497452:Idb2 protein, mouse; C494258:Irf1 protein, mouse; C494230:Irf2 protein, mouse