Changes of electroencephalographic bicoherence during isoflurane anesthesia combined with epidural anesthesia.
BACKGROUND
The authors previously reported that, during isoflurane anesthesia, electroencephalographic bicoherence values changed in a fairly restricted region of frequency versus frequency space. The aim of the current study was to clarify the relation between electroencephalographic bicoherence and the isoflurane concentration.


METHODS
Thirty elective abdominal surgery patients (male and female, aged 34-77 yr, American Society of Anesthesiologists physical status I-II) were enrolled. After electroencephalogram recording with patients in an awake state, anesthesia was induced with 3 mg/kg thiopental and maintained with oxygen and isoflurane. Continuous epidural anesthesia with 80-100 mg/kg 1% lidocaine was also administered. Using software they developed, the authors continuously recorded the FP1-A1 lead of the electroencephalographic signal and expired isoflurane concentration to an IBM-PC compatible computer. After confirming the steady state of each isoflurane (end-tidal concentration at 0.3, 0.5, 0.7, 0.9, 1.1, 1.3, and 1.5%), electroencephalographic bicoherence values were calculated.


RESULTS
In a light anesthetic state, electroencephalographic bicoherence values were low (generally < or = 15.0%). At increased concentrations of isoflurane, two peaks of electroencephalographic bicoherence emerged along the diagonal line (f1=f2). The peak emerged at around 4.0 Hz and grew higher as isoflurane concentration increased until it reached a plateau (43.8 +/- 3.5%, mean +/- SD) at isoflurane 0.9%. The other peak, at about 10.0 Hz, also became significantly higher and reached a plateau (32.6 +/- 9.2%) at isoflurane 0.9%; at isoflurane 1.3%, however, this peak slightly decreased.


CONCLUSIONS
Changes in the height of two electroencephalographic bicoherence peaks correlated well with isoflurane concentration.
Hagihira
Satoshi
S
Department of Anesthesiology, Osaka Prefectural Habikino Hospital, 3-7-1 Habikino, Habikino City, Osaka, Japan 583-8588. hagihira@masui.med.osaka-u.ac.jp
Takashina
Masaki
M
Mori
Takahiko
T
Mashimo
Takashi
T
Yoshiya
Ikuto
I
D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged
D018685:Anesthetics, Inhalation; D007530:Isoflurane