Rheological properties of healthy and atherosclerotic human arteries.
The aim of this study was to determine the comparative three-dimensional mechanical properties of healthy and atherosclerotic muscular human arteries. Using a previously developed experimental system, in vitro inflation tests were performed on twelve segments of arteries, in static conditions. Two different initial states were used to carry the mechanical study through (large deformation, thick-walled). Main significant differences between healthy and atherosclerotic tested segments are observed for axial traction force whatever the initial state and radial and circumferencial strains referenced to longitudinally pre-stretched state. We showed that strain energy allows to differentiate between both types of arteries only when absolute values of transversal components were considered. Differential values of energy were not discriminating. Our results also show the potential interest of studying arteries in vivo at low transmural pressure.
Blondel
Walter C P M
WC
Cell and Tissue Mechanics and Engineering Laboratory (LEMTA), UMR CNRS 7563 and IFR Bio-Engineering, Faculty of medicine, 54500 Vandoeuvre-lès-Nancy, France.
Lehalle
Bertrand
B
Lercher
Marie-Noëlle
MN
Dumas
Dominique
D
Bensoussan
Danielle
D
Stoltz
Jean-François
JF
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001158:Arteries / Q000502:physiology* / Q000503:physiopathology; D001161:Arteriosclerosis / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D007866:Leg / Q000098:blood supply; D010812:Physical Stimulation / Q000379:methods; D011312:Pressure; D012212:Rheology; D013314:Stress, Mechanical