title: Long-time microdialysis in a patient with meningoencephalitis.
abstract: As part of invasive neuromonitoring, long-time microdialysis was performed in a 32-year-old patient suffering from meningoencephalitis. Cerebral magnetic resonance imaging (MRI) revealed marked global brain oedema. An intracranial pressure (ICP) probe, brain tissue oxygen pressure measurement (pTiO(2)), and intraparenchymal microdialysis were used for intensive neuromonitoring. Despite high ICP, only intensive care therapy was applied for 16 days using deep propofol sedation, hyperventilation, and intermittent mannitol therapy. One year later, the condition of the patient was excellent. Intracerebral microdialysis with bedside measuring of lactate, pyruvate, glycerol, glucose, and glutamate is a useful additional tool for the monitoring of ICP management.
authors.affiliation: Department of Neurosurgery, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. jan.gliemroth@t-online.de
authors.forename: Jan
authors.initials: J
authors.lastname: Gliemroth
authors.forename: Ludger
authors.initials: L
authors.lastname: Bahlmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Klaus
authors.forename: Anke
authors.initials: A
authors.lastname: Klöhn
authors.forename: Hans
authors.initials: H
authors.lastname: Arnold
mesh_terms: D000328:Adult; D001929:Brain Edema / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003131:Combined Modality Therapy; D004234:Diuretics, Osmotic / Q000627:therapeutic use; D005947:Glucose / Q000378:metabolism; D018698:Glutamic Acid / Q000097:blood; D005990:Glycerol / Q000097:blood; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D019344:Lactic Acid / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008590:Meningoencephalitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D017551:Microdialysis / Q000379:methods*; D019289:Pyruvic Acid / Q000097:blood; D012121:Respiration, Artificial / Q000379:methods; D012141:Respiratory Tract Infections / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D004234:Diuretics, Osmotic; D019344:Lactic Acid; D018698:Glutamic Acid; D008353:Mannitol; D019289:Pyruvic Acid; D005947:Glucose; D005990:Glycerol