[Antitumor effect of combined treatment with ionizing radiation and vitamin B12-C complex].
The combined effect of ionizing radiation (0.5-4 Gy) and the vitamin B12-C complex on life-span of mice with Ehrlich carcinomas was studied. It was shown that antitumor effect of the combined treatment strictly depends on the sequence of the agent applying and on the time interval between them. For example, the combined treatment increased essentially the life-span of mice if the vitamins were used 24 h after irradiation but with the reverse order of influences, the antitumor effect was less than that of the vitamin complex only. It was supposed that the discovered regularities are due to tumor cell synchronization or division stimulation with the first influence.
Levitman
M Kh
MKh
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Russia.
Kublik
L N
LN
Shaposhnikova
V V
VV
Akatov
V S
VS
Korystov
Iu N
IuN
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D008297:Male; D051379:Mice; D011879:Radiotherapy Dosage; D013997:Time Factors; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000627:therapeutic use*
D014805:Vitamin B 12; D001205:Ascorbic Acid