title: Long-term rectal administration of high-dose sustained-release morphine tablets.
abstract: Two proprietary sustained-release morphine tablets for oral administration are available in the USA, and the authors have found that rectal administration of these provide excellent analgesia although their use by this route is not approved by the United States Food and Drug Administration. An illustrative case in a 72-year-old patient with prostate cancer is reported.
authors.affiliation: The Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA. walsht@ccf.org
authors.forename: Declan
authors.initials: D
authors.lastname: Walsh
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Tropiano
mesh_terms: D000285:Administration, Rectal; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D001859:Bone Neoplasms / Q000150:complications* / Q000556:secondary; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D009325:Nausea / Q000139:chemically induced; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011471:Prostatic Neoplasms / Q000473:pathology; D013607:Tablets / Q000008:administration & dosage
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D013607:Tablets; D009020:Morphine