Coagulation pathways in atherothrombosis.
Atherosclerosis is a disease recognized as the main cause of death in industrial countries. The current paradigm establishes thrombosis to be the major reason for complications of atherosclerosis, such as myocardial infarction and stroke, and the major factor responsible for atherosclerosis-related mortality. Development of adequate treatment of patients with risk of atherothrombosis requires the comprehensive understanding of mechanisms underlying coagulation processes at the site of atherosclerotic lesion. The present review discusses contribution of the extrinsic and intrinsic pathways of blood coagulation in thrombogenicity of atherosclerotic plaque and factors determining the overall procoagulant/anticoagulant balance.
Khrenov
Alexey V
AV
Department of Biochemistry, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA.
Ananyeva
Natalya M
NM
Griffin
John H
JH
Saenko
Evgueni L
EL
D000818:Animals; D001161:Arteriosclerosis / Q000150:complications* / Q000503:physiopathology*; D001777:Blood Coagulation / Q000502:physiology*; D006801:Humans; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology*