Regulation of mitochondrial gene expression by retinoids.
Several nuclear hormone receptors have been localized to the mitochondrial compartment. Evidence supports the hypothesis that these receptors directly regulate mitochondrial transcription. Retinoic acid has also been shown to regulate mitochondrial transcription and function. This review discusses mechanisms of mitochondrial transcription and how retinoic acid may either indirectly or directly regulate mitochondrial transcription. How retinoic acid may affect individual nutrient requirements is also discussed.
Everts
Helen B
HB
Department of Foods and Nutrition, University of Georgia, Athens 30602, USA.
Berdanier
Carolyn D
CD
D000818:Animals; D001665:Binding Sites; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism*; D005544:Forecasting; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D018168:Receptors, Retinoic Acid / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D014158:Transcription, Genetic; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology*
D004272:DNA, Mitochondrial; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; D014212:Tretinoin