Extinction of operant behavior as the test for cognitive disorders induced with kainic acid.
Wistar rats were trained food-procuring task for 5 days and then extinction of the operant behavior was studied for 6 days after injection of an epileptogen (kainic acid, 8 mg/kg, intraperitoneally). Kainic acid induced long-term impairment of inhibitory processes in the brain, which impeded extinction of a conditioned response. This effect was prevented by daily injections of anticonvulsant sodium valproate (300 mg/kg for 4 days).
Arkhipov
V I
VI
Laboratory of Synaptic Transmission Mechanisms, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Puschino, Russia. arkhipov@iteb.serpukhov.su
Shevchenko
N A
NA
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003072:Cognition Disorders / Q000139:chemically induced / Q000523:psychology*; D003216:Conditioning, Operant / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D007608:Kainic Acid; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000494:pharmacology
D000927:Anticonvulsants; D014635:Valproic Acid; D007608:Kainic Acid