Transport of xenobiotics across the blood-brain barrier.
Distinct transport proteins regulate the movement of waste products and xenobiotics across the blood-brain barrier (BBB). Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain.
Hagenbuch
Bruno
B
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland.
Gao
Bo
B
Meier
Peter J
PJ
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D015262:Xenobiotics / Q000493:pharmacokinetics*
D002352:Carrier Proteins; D015262:Xenobiotics