title: Electro-magnetic base technology for estremely sensitive immunosensors and DNA-chips.
abstract: We report on the development of an innovative electro-magnetic base technology for estremely sensitive sensors allowing the electrical detection of biological analytes like antigenes or DNA as well as a simple multiple detection of binding forces occurring at specific bonds between proteins. The technology is based on the strong impact of specifically captured magnetic microbeads on an electrical current generated in a fluid by a small sensor chip with an array of activated microelectrodes. The new technological principle with the on-chip detection of analytes will be suitable for large scale applications due to its mass production compatible technologies and allow an alternative way to monitor relevant substances without the consumption of critical additional solutions and reagents.
authors.affiliation: Institut für Chemo- und Biosensorik (ICB) e.V., D-48149 Münster, Deutschland. a.gorschlueter@icb-online.de
authors.forename: A
authors.initials: A
authors.lastname: Gorschlüter
authors.forename: L H
authors.initials: LH
authors.lastname: Mak
authors.forename: C
authors.initials: C
authors.lastname: Sundermeier
authors.forename: B
authors.initials: B
authors.lastname: Ross
authors.forename: M
authors.initials: M
authors.lastname: Knoll
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation; D004563:Electrochemistry / Q000295:instrumentation; D004574:Electromagnetic Fields; D004867:Equipment Design; D006801:Humans; D008839:Microelectrodes; D015166:Monitoring, Immunologic / Q000295:instrumentation*; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D014159:Transducers