Accuracy of the urinary albumin to creatinine ratio as a predictor of albuminuria in adults with sickle cell disease.
OBJECTIVE
To test the usefulness of a random urine specimen albumin to creatinine ratio (A/C) in predicting 12 hour urinary albumin excretion (12UA) in patients with sickle cell disease.


METHODS
12UA and A/C were measured in nocturnal urine collections and random morning urine samples, respectively, of 72 patients with sickle cell disease.


RESULTS
The correlation of A/C values with 12UA values did not provide support for the use of random urine specimens for predicting urinary albumin excretion (UAE) in these patients. However, values of A/C >/= 0.45 and < 0.45 were indicative of raised and normal UAE, respectively. The sensitivity, specificity, and accuracy of the test were 100.0%, 87.2%, and 91.7%, respectively.


CONCLUSIONS
This method cannot be recommended for predicting 12UA in patients with sickle cell disease, but it is useful for selecting patients who should collect 12 hour urine for the estimation of UAE.
Lima
C S P
CS
Haematology and Haemotherapy Centre, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil. carmenl@obelix.unicamp.br
Bottini
P V
PV
Garlipp
C R
CR
Santos
A O
AO
Costa
F F
FF
Saad
S T O
ST
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000175:diagnosis* / Q000209:etiology*; D000755:Anemia, Sickle Cell / Q000150:complications*; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods
D015415:Biomarkers; D003404:Creatinine