Arginine vasopressin in the pathogenesis of febrile convulsion and temporal lobe epilepsy.
We aimed to investigate the possible convulsant action of arginine vasopressin (AVP) in both a febrile convulsion model in rat pups and a temporal lobe epilepsy model in adult rats and to define the receptor type which mediates this effect. In rat pups, 125 ng V2 receptor antagonist significantly prevented hyperthermic seizures, but did not affect seizure latency. In adult rats, the only effective dose and agent was 125 ng V2 receptor antagonist, which prevented pilocarpine-induced status epilepticus, extended the status epilepticus latency and improved the 24 h survival rate. These data suggest that AVP has a convulsant activity in febrile convulsions and also in seizures independent of fever, and this effect is mediated by V2 receptors.
Gulec
Guldal
G
Uludag University Medical Faculty, Department of Physiology, 16059 Görükle, Bursa, Turkey. guldal@uludag.edu.tr
Noyan
Behzat
B
D000818:Animals; D000831:Animals, Newborn; D000927:Anticonvulsants / Q000494:pharmacology*; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000009:adverse effects* / Q000378:metabolism; D003292:Convulsants / Q000009:adverse effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D003294:Seizures, Febrile / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D013226:Status Epilepticus / Q000188:drug therapy; D015996:Survival Rate
D000927:Anticonvulsants; D065092:Antidiuretic Hormone Receptor Antagonists; D003292:Convulsants; D010862:Pilocarpine; D001127:Arginine Vasopressin