[Present situation regarding development of an HIV vaccine].
The AIDS epidemic continues to advance, and the development of a preventive HIV vaccine has become a major objective for scientific research. An effective vaccine against this virus is not available and complete protection still has not been achieved in animal models. In this review the major challenges related to the development of a vaccine against HIV are analyzed, particularly the mechanisms involved in viral escape from the immune response, and the results obtained with the various therapeutic and preventive vaccine prototypes are summarized. Finally, the social, economic and health aspects related to research on HIV vaccines and the current controversy around the performance of clinical trials with these agents is discussed.
Alcami
José
J
Unidad de Inmunopatología del SIDA. Centro Nacional de Microbiología. Instituto de Salud Carlos III. Madrid. España. ppalcami@isciii.es
D016915:AIDS Vaccines / Q000096:biosynthesis / Q000627:therapeutic use*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D000917:Antibody Formation / Q000276:immunology / Q000502:physiology; D002986:Clinical Trials as Topic / Q000941:ethics; D000939:Epitopes; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology / Q000502:physiology; D014613:Vaccines, Attenuated / Q000096:biosynthesis / Q000276:immunology / Q000627:therapeutic use; D019444:Vaccines, DNA / Q000276:immunology; D015164:Vaccines, Inactivated / Q000096:biosynthesis / Q000276:immunology / Q000627:therapeutic use; D014764:Viral Proteins / Q000276:immunology
D016915:AIDS Vaccines; D000939:Epitopes; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D015164:Vaccines, Inactivated; D014764:Viral Proteins