Ecdysteroids of Vitex scabra stem bark.
Two new ecdysteroids, 24-epi-pinnatasterone (1) and scabrasterone (2), together with 11 known ecdysteroids, calonysterone, pterosterone, 24-epi-makisterone A, 20-hydroxyecdysone (3), polypodine B, ajugasterone C, pinnatasterone (4), 11alpha-hydroxyecdysone, 24-epi-abutasterone, 20,26-dihydroxyecdysone, and turkesterone (5), were isolated from the stem bark of Vitex scabra. This plant species contained a very high concentration (1.8%) of 3 and thus provided a good source of this parent ecdysteroid and related rare ecdysteroids. Compounds 1 and 2 exhibited very low moulting activity in the Musca bioassay. The low biological activity of these two ecdysteroids was in agreement with those of other 22-deoxyecdysteroids.
Suksamrarn
Apichart
A
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand. apichart@ram1.ru.ac.th
Kumpun
Saowanee
S
Yingyongnarongkul
Boon-Ek
BE
D000107:Acetylation; D002855:Chromatography, Thin Layer; D026461:Ecdysteroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D028521:Musa / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand; D020950:Vitex / Q000737:chemistry*
C471826:24-epi-pinnatasterone; D026461:Ecdysteroids; C471825:scabrasterone