Effects of methyllycaconitine and related analogues on bovine adrenal alpha3beta4* nicotinic acetylcholine receptors.
Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.
Bryant
Darrell L
DL
Division of Pharmacology, The Ohio State University, College of Pharmacy, Columbus, Ohio 43210, USA.
Free
R Benjamin
RB
Thomasy
Sara M
SM
Lapinsky
David J
DJ
Ismail
K A
KA
Arason
K M
KM
Bergmeier
Stephen C
SC
McKay
Dennis B
DB
D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D018733:Nicotinic Antagonists / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000378:metabolism*
D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; C403530:nicotinic receptor alpha3beta4; C054634:methyllycaconitine; D000157:Aconitine