A clinical evaluation of implants in irradiated oral cancer patients.
In this prospective study, we determined the effects of the time interval between irradiation and implant therapy, implant location, bone-resection surgery, and irradiation dose on implant survival. We analyzed the survival of 446 implants inserted after radiotherapy over a period of up to 14 years in 130 consecutive patients treated for oral cancer. The 10-year overall Kaplan-Meier implant survival percentage is 78%. The difference in survival percentages of implants inserted < 1 year and >/= 1 year after irradiation (76% and 81%, respectively) is not significant. We concluded that implant survival is significantly influenced by the location (maxilla or mandible, 59% and 85%, respectively; p = 0.001), by the incidence of bone-resection surgery in the jaw where the implant was installed (p = 0.04), and by the irradiation dose at the implant site (< 50 Gray or >/= 50 Gray, p = 0.05).
Visch
L L
LL
Department of Oral Function, Academic Center for Dentistry, Louwesweg 1, 1066EA Amsterdam, The Netherlands. visch-implant@hetnet.nl
van Waas
M A J
MA
Schmitz
P I M
PI
Levendag
P C
PC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016371:Cranial Irradiation / Q000009:adverse effects*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019232:Dental Restoration Failure; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008437:Maxilla / Q000601:surgery; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D016019:Survival Analysis; D013997:Time Factors
D015921:Dental Implants