Corneal opacifications in a low high density lipoprotein syndrome: suspicion of fish eye disease: a case report.
A 49 year old patient with progressive massive bilateral corneal opacifications associated with a HDL (high-density-lipoprotein) deficiency is described. The opacifications started at the age of twenty and progressed slowly. They were found diffusely over the cornea, though more in the corneal periphery. A penetrating keratoplasty at the right eye was performed. The diagnosis of Fish Eye Disease was put forward on the basis of the ophthalmological, clinical, biochemical and pathological appearance. After 2 year follow-up, the graft was clear. The final distance and near vision of the right eye was 8/10 and Snellen 1 respectively.
De Smedt
M
M
Department of Ophthalmology, Katholieke Universiteit Leuven, Belgium.
Van Ginderdeuren
R
R
De Vos
R
R
Mertens
A
A
Muls
E
E
Foets
B
B
D000328:Adult; D003318:Corneal Opacity / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008875:Middle Aged; D013631:Tangier Disease / Q000150:complications* / Q000175:diagnosis*