Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction.
[reaction: see text] Ugi condensation was used to synthesize the first examples of chiral racemic Ar.Cr(CO)(3) labeled peptide nucleic acid (PNA) monomers bearing the organometallic moiety linked to the alpha-carbon of the glycine unit.
Baldoli
Clara
C
CNR Istituto di Scienze e Tecnologie Molecolari e Dipartimento di Chimica Organica e Industriale, University of Milan, Via C. Golgi 19, I-20133 Milano, Italy.
Maiorana
Stefano
S
Licandro
Emanuela
E
Zinzalla
Giovanna
G
Perdicchia
Dario
D
D017608:Chromium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D017608:Chromium Compounds; D020135:Peptide Nucleic Acids; D013941:Thymine