In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes.
Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.
Kazakova
T B
TB
Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Barabanova
S V
SV
Khavinson
V Kh
VKh
Glushikhina
M S
MS
Parkhomenko
E P
EP
Malinin
V V
VV
Korneva
E A
EA
D000818:Animals; D002478:Cells, Cultured; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D007376:Interleukin-2 / Q000235:genetics*; D051379:Mice; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects; D013997:Time Factors
D004151:Dipeptides; D007376:Interleukin-2; D009842:Oligopeptides; D010455:Peptides; C431545:alanyl-glutamyl-aspartylprolyine; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine