Mohs micrographic surgery for dermatofibrosarcoma protuberans: University of Miami and NYU experience.
BACKGROUND
Dermatofibrosarcoma protuberans (DFSP) is a relatively rare cutaneous malignancy with the potential for significant local destruction and morbidity. This neoplasm has a tendency for recurrence following excision due to its infiltrative nature. Surgical excision with wide margins has been considered the standard therapy for DFSP but has had reported recurrence rates of up to 60%.


OBJECTIVE
The results of 20 patients with DFSP treated with Mohs micrographic surgery (MMS) are reported. We also reviewed the world literature on the role of MMS for treatment of this tumor.


METHODS
Twenty patients between the ages of 20 and 82 years with DFSP were treated with MMS. The patients were followed for recurrences between 4 and 216 months (mean 56.4 months).


RESULTS
None of the 20 patients had a recurrence of DFSP following MMS. Of 221 DFSP patients in our review of the world literature treated with MMS, only 5 (2.3%) had a recurrence.


CONCLUSIONS
MMS is an effective treatment of DFSP.
Nouri
Keyvan
K
Department of Dermatology, University of Miami School of Medicine, Miami, Florida, USA.
Lodha
Rashmi
R
Jimenez
Gloria
G
Robins
Perry
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018223:Dermatofibrosarcoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome