Modelling 'evo-devo' with RNA.
The folding of RNA sequences into secondary structures is a simple yet biophysically grounded model of a genotype-phenotype map. Its computational and mathematical analysis has uncovered a surprisingly rich statistical structure characterized by shape space covering, neutral networks and plastogenetic congruence. I review these concepts and discuss their evolutionary implications.
Fontana
Walter
W
Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA. walter@santafe.edu
D000465:Algorithms; D005838:Genotype; D007700:Kinetics; D016571:Neural Networks, Computer; D009690:Nucleic Acid Conformation; D010641:Phenotype; D010802:Phylogeny; D012313:RNA / Q000737:chemistry* / Q000502:physiology*; D013696:Temperature; D013816:Thermodynamics; D013997:Time Factors
D012313:RNA