Protein transduction: a novel tool for tissue regeneration.
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the risk of cancer formation a protein therapy approach has been developed. The transient delivery of proteins rather than genes could still induce terminally-differentiated cells to reenter the cell cycle. This approach takes advantage of protein-transducing domains that mediate the transfer of cargo proteins into cells. The goal of this brief review is to outline the basics of protein transduction and to discuss potential applications for tissue regeneration.
Cardoso
M Cristina
MC
Max Delbrück Center for Molecular Medicine, D-13125 Berlin, Germany.
Leonhardt
Heinrich
H
D000595:Amino Acid Sequence; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012038:Regeneration / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*; D015678:Viral Structural Proteins / Q000235:genetics / Q000378:metabolism
D011506:Proteins; D011993:Recombinant Fusion Proteins; D015678:Viral Structural Proteins