A patient with paroxysmal nocturnal haemoglobinuria in whom granulocyte colony-stimulating factor administration resulted in improvement of recurrent enterocolitis and its associated haemolytic attacks.
We report an elderly patient with paroxysmal nocturnal haemoglobinuria (PNH), having recurrent enterocolitis and haemolytic attacks associated with cellular immunodeficiency. On admission, the patient had normal neutrophil count and function but a decreased T-cell count, decreased mitogenic reactions, and a negative tuberculin test. Granulocyte colony-stimulating factor (G-CSF) was administered, resulting in an increased T-cell count, normalization of T-cell function, increased blood levels of helper T cell (Th)1 and Th2 cytokines and improvement in the enterocolitis and haemolytic attacks. This suggests that G-CSF may be useful in the treatment of elderly PNH patients with cellular immunodeficiency.
Fujimi
Akihito
A
4th Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan.
Matsunaga
Takuya
T
Kogawa
Katsuhisa
K
Ohnuma
Takayuki
T
Takahira
Naoki
N
Abe
Tomoyuki
T
Kitaoka
Keisuke
K
Kogawa
Takahiro
T
Tanaka
Ikuta
I
Morii
Kazuhiro
K
Terui
Takeshi
T
Sakamaki
Sumio
S
Kato
Junji
J
Kura
Toshiro
T
Maeda
Takeshi
T
Niitsu
Yoshiro
Y
D000368:Aged; D004760:Enterocolitis / Q000517:prevention & control*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006457:Hemoglobinuria, Paroxysmal / Q000188:drug therapy*; D006801:Humans; D008231:Lymphopenia / Q000188:drug therapy / Q000209:etiology; D055502:Secondary Prevention; D013601:T-Lymphocytes
D016179:Granulocyte Colony-Stimulating Factor