title: Hemolytic characteristics of oxygenators during clinical extracorporeal membrane oxygenation.
abstract: A connection was previously reported between the hemolytic characteristics associated with oxygenators and the pressure drop measurements in the blood chamber under experimental conditions simulating their use in cardiopulmonary bypass. We examined this association during extracorporeal membrane oxygenation (ECMO) conditions. Three oxygenators for ECMO or pediatric cardiopulmonary bypass (Menox EL4000, Dideco Module 4000, and Mera HPO-15H) were evaluated. Fresh blood from healthy Dexter strain calves anticoagulated with citrate phosphate dextrose adenine solution was used. The blood flow was fixed at 1 L/min, similar to that in ECMO. The Normalized Index of Hemolysis for Oxygenators (NIHO) has been modified according to the American Society of Testing and Materials standards, as was previously reported. The NIHO value was the lowest in the Menox (0.0070+/-0.0009) and increased from Menox to Dideco (0.0113+/-0.0099) to Mera (0.0164+/-0.0043); however, there were no significant differences among the oxygenators. This NIHO value has a close correlation to the pressure drop. In conclusion, this evaluation method is also applicable to comparison of the biocompatibility performance of different types of clinically available oxygenators for ECMO.
authors.affiliation: Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Houston, USA.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawahito
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Motomura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishitoya
authors.forename: Tamaki
authors.initials: T
authors.lastname: Takano
authors.forename: Kenji
authors.initials: K
authors.lastname: Nonaka
authors.forename: Joerg
authors.initials: J
authors.lastname: Linneweber
authors.forename: Seiji
authors.initials: S
authors.lastname: Ichikawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Kawamura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hanazaki
authors.forename: Julie
authors.initials: J
authors.lastname: Glueck
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D002417:Cattle; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods* / Q000592:standards; D006461:Hemolysis; D012016:Reference Values