[Detection of circulating Candida albicans mannan and antimannan antibodies: useful for diagnosis of deep seated candidiasis].
In deep seated candidiasis, only 40% of blood cultures are positive. The aim of the study was to investigate circulating Candida albicans mannan and anti-mannan antibodies as a possible help for the diagnosis of deep seated candidiasis. We have compared the results to the detection of IgM by Elisa and antibodies by immunoflourescence. The best tests, in accord to their sensitivity and specificity, are the mannan antigenemia (43% and 100%) and IgM (86% and 100%) and have to be used together.
Eloy
O
O
Service de microbiologie, Hôpital André Mignot, 177 rue de Versailles, 78157 le Chesnay, France.
Tabella
C
C
Harzic
M
M
Pina
P
P
Allouch
P
P
Pangon
B
B
Bedos
J P
JP
Ghnassia
J C
JC
D000908:Antibodies, Fungal / Q000097:blood*; D002176:Candida albicans / Q000302:isolation & purification*; D002177:Candidiasis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008351:Mannans / Q000097:blood* / Q000276:immunology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D000908:Antibodies, Fungal; D007075:Immunoglobulin M; D008351:Mannans