Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease.
Epidemiological and pathogenetic evidences suggest a strong association between vascular risk factors and sporadic Alzheimer's disease (sAD). In agreement with the vascular hypothesis of AD, the role of various candidate genes for atherosclerosis has been investigated, leading to conflicting results. In order to clarify the significance of angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism in a group of patients with sAD, we conducted a case-control study including 149 cases and 149 age and sex matched controls. All subjects were genotyped for ACE and Apolipoprotein E (APOE). There were no significant differences in ACE genotype or allele frequencies between cases and controls, even after stratification for APOE4 carrier status. Our data suggest that the ACE I/D polymorphism is not associated to genetic susceptibility in sAD patients.
Monastero
Roberto
R
Department of Neurology and Rehabilitation, Centre for Aging Brain and Dementia, University of Palermo, Palermo, Italy.
Caldarella
Rosalia
R
Mannino
Marina
M
Cefalù
Angelo B
AB
Lopez
Gianluca
G
Noto
Davide
D
Camarda
Cecilia
C
Camarda
Lawrence K C
LK
Notarbartolo
Alberto
A
Averna
Maurizio R
MR
Camarda
Rosolino
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D001057:Apolipoproteins E; D007703:Peptidyl-Dipeptidase A