Ribozyme-catalysed carbon-carbon bond formation.
Numerous RNA molecules with new catalytic properties have been isolated from synthetic combinatorial libraries. A broad range of chemical reactions is catalysed, and nucleic acids can accelerate bond formation between small organic substrates. This review focuses on carbon-carbon bond formation accelerated by in vitro selected ribozymes. Mechanistic investigations and structure-function relationships are discussed.
Jäschke
A
A
Department of Biology, Chemistry & Pharmacy, Institute of Chemistry, Freie Universität Berlin, Thielallee 63, Germany. jaeschke@uni-hd.de
Stuhlmann
F
F
Bebenroth
D
D
Keiper
S
S
Wombacher
R
R
D001483:Base Sequence; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D016337:RNA, Catalytic / Q000737:chemistry*
D016337:RNA, Catalytic; D012313:RNA; D002244:Carbon