title: Molecular typing of Mycobacterium tuberculosis strains with a common two-band IS6110 pattern.
abstract: We conducted a program of population-based molecular typing of all Mycobacterium tuberculosis isolates obtained in Alabama since 1994. Of 2452 isolates, 1013 (41%) had fewer than 6 bands of IS6110; 348 (14%) had a single two-band pattern (JH2). With conventional epidemiologic methods, we identified three groups of related patients with JH2 isolates. Spoligotyping and pattern of variable number of tandem repeats identified 10 molecular groups; two found by conventional methods were subdivided.
authors.affiliation: University of Alabama School of Medicine, Birmingham, Alabama 35294-0022, USA.
authors.forename: Kerry H
authors.initials: KH
authors.lastname: Lok
authors.forename: William H
authors.initials: WH
authors.lastname: Benjamin
authors.forename: Michael E
authors.initials: ME
authors.lastname: Kimerling
authors.forename: Virginia
authors.initials: V
authors.lastname: Pruitt
authors.forename: Donna
authors.initials: D
authors.lastname: Mulcahy
authors.forename: Nancy
authors.initials: N
authors.lastname: Robinson
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Keenan
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Dunlap
mesh_terms: D000407:Alabama / Q000453:epidemiology; D015373:Bacterial Typing Techniques; D016172:DNA Fingerprinting; D024881:Drug Resistance, Bacterial; D014644:Genetic Variation; D006801:Humans; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology*