title: [Peculiarities of immune responses during general anesthesia in otosurgery].
abstract: Immune responses were investigated in 118 patients suffering from chronic purulent inflammation of middle ear. All of them were operated under different methods of anesthesia. Immunotherapy preceding intravenous anesthesia with combination of phentanyl and clophelline along with supporting spontaneous breathing was found to be the most optimal from the immunologic point of view. This anesthetic approach has such advantages as IgG, IgA elevation by 50%-100% and sIgA secretory antibodies content increment by 30% in local mucosal immune system, activating the macrophageal-phagocyte system of antigen treatment.
authors.forename: A A
authors.initials: AA
authors.lastname: Starchenko
authors.forename: S A
authors.initials: SA
authors.lastname: Komarets
authors.forename: G V
authors.initials: GV
authors.lastname: Lavrenova
authors.forename: S V
authors.initials: SV
authors.lastname: Kraskovskaia-Dimitriuk
authors.forename: T I
authors.initials: TI
authors.lastname: Prilukova
mesh_terms: D000768:Anesthesia, General / Q000379:methods*; D000777:Anesthetics / Q000008:administration & dosage / Q000009:adverse effects*; D000917:Antibody Formation / Q000187:drug effects*; D004432:Ear, Middle / Q000276:immunology / Q000601:surgery*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D010033:Otitis Media / Q000276:immunology* / Q000601:surgery
chemical_list: D000777:Anesthetics; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M