title: The role of matrix metalloproteinases in rheumatoid tendon disease.
abstract: In rheumatoid arthritis (RA) invasive tenosynovitis is associated with an increase in tendon rupture, although little is known about the mechanisms involved. We obtained specimens of noninvasive encapsulating tenosynovium, invasive tenosynovium, and wrist joint synovium from 28 rheumatoid patients. In vitro production of the matrix metalloproteinase (MMP) enzymes, MMP-8 and -9, and total collagenase activity were measured. Invasive tenosynovium produced highest levels of the collagenase MMP-8 and displayed significantly greater ability to degrade collagen type I than encapsulating tenosynovium. Levels of the gelatinase enzyme MMP-9 were similar in all groups. These results show that invasive tenosynovium is more destructive than encapsulating tenosynovium at a molecular level, providing an explanation for the increased tendon rupture associated with invasive tenosynovitis in RA.
authors.affiliation: Department of Musculoskeletal Surgery and the Kennedy Institute of Rheumatology, Imperial College School of Medicine, The Charing Cross Hospital Campus, London, UK.
authors.forename: Abhilash
authors.initials: A
authors.lastname: Jain
authors.forename: Fionula
authors.initials: F
authors.lastname: Brennan
authors.forename: Linda
authors.initials: L
authors.lastname: Troeberg
authors.forename: Jagdeep
authors.initials: J
authors.lastname: Nanchahal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism*; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D012421:Rupture / Q000201:enzymology / Q000209:etiology; D013583:Synovial Membrane / Q000201:enzymology; D013710:Tendons / Q000201:enzymology*; D014955:Wrist Joint / Q000201:enzymology
chemical_list: D024042:Collagen Type I; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9