Bulbourethral Gland Cysts in Three Mice.
Diseases of bulbourethral glands have rarely been reported in mice. The present report describes bulbourethral gland cysts in three male mice: a.1yearold DBA/2J mouse (case 1), a 10monthold nude mouse (case 2), and a 4.5monthold chimeric mouse (case 3). Round to oval fluctuant nodules were observed on their dorsal perineum. The nodules in cases 1 and 2 were pale, pink to tan, soft, and glistening; in case 3, the mass was purple-red and soft. All nodules were located subcutaneously between the bulbospongiosus and ischiocavernous muscles, with a deep connection to the urethra. The nodules were 13 mm (case 1), 6 mm (case 2), and 8 mm (case 3) in diameter. The cut surface of the nodules was cystic; the lumina were filled with clear gelatinous or viscous (cases 1 and 2) or thin blood-tinged fluid (case 3). The nodules comprised irregular cysts and acini that were lined by a single layer of cuboidal, pyramidal to tall columnar epithelial cells with little stroma. Bulbourethral gland cysts should be included as differential diagnoses for perineal nodules or swellings in mice.
Wardrip
Craig L.
CL
Department of Surgery and the Committee on Comparative Medicine and Pathology, The University of Chicago, Chicago, IL 60637.
Lohmiller
Jeffrey J.
JJ
Swing
Sonya P.
SP
Seps
Steven L.
SL
Li
Xiantang
X