title: Role of tissue polypeptide specific antigen in the detection of prostate cancer.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the role of tissue polypeptide specific antigen (TPS) in the diagnosis of different stages of prostatic cancer (CaP) and to compare the diagnostic efficacy of serum TPS in respect to total prostate-specific antigen (tPSA) and free/total (f/t) PSA ratio.
  
  
  METHODS
  Patients with BPH (n = 58), localized CaP (n = 37) and metastatic CaP (n = 16) were compared by measuring serum TPS, tPSA and f/t PSA ratio.
  
  
  RESULTS
  Serum TPS was significantly increased only in patients with metastatic CaP (p < 0.05) and TPS levels was not significantly different between patients with BPH and localized CaP. Both f/tPSA and tPSA showed better sensitivity, specificity and receiver operating curve analysis in the differential diagnosis of BPH and localized CaP.
  
  
  CONCLUSIONS
  In conclusion, serum TPS measurement was found to be significantly increased in metastatic prostatic carcinoma cases but was not useful in the early detection of prostatic carcinoma. Although there are several studies demonstrating the usefulness of TPS in the differential diagnosis of prostate cancer, there is increasing evidence for the use of this molecule in the late period of the disease or as an adjunct to other molecules in the detection of recurrences.
authors.affiliation: Department of Urology, Firat University School of Medicine, Elazig,Turkey. rahmionur@yahoo.com
authors.forename: Rahmi
authors.initials: R
authors.lastname: Onur
authors.forename: Irfan
authors.initials: I
authors.lastname: Orhan
authors.forename: Necip
authors.initials: N
authors.lastname: Ilhan
authors.forename: Atilla
authors.initials: A
authors.lastname: Semercioz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D010455:Peptides; C089984:tissue polypeptide specific antigen