Antimicrobial resveratrol tetramers from the stem bark of Vatica oblongifoliassp. oblongifolia.
Two new resveratrol tetramers, hopeaphenol A (1) and isohopeaphenol A (2), along with the known vaticaphenol A (3), were isolated from the stem bark of Vatica oblongifolia ssp. oblongifolia through bioassay-guided fractionation. The structures and their relative stereochemistry were determined by spectroscopic techniques. Compounds 1 and 3 demonstrated moderate activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.
Zgoda-Pols
Joanna R
JR
Graduate Program in Pharmacognosy, Department of Chemistry and Biochemistry, and Department of Biological Sciences, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, Pennsylvania 19104-4495, USA.
Freyer
Alan J
AJ
Killmer
Lew B
LB
Porter
John R
JR
D020448:Ericales / Q000737:chemistry*; D008296:Malaysia; D016106:Methicillin Resistance; D008968:Molecular Conformation; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D000077185:Resveratrol; D013211:Staphylococcus aureus / Q000187:drug effects; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D013267:Stilbenes; C471485:hopeaphenol A; C471486:isohopeaphenol A; C471487:vaticaphenol A; D000077185:Resveratrol