Gadobenate dimeglumine-enhanced MR angiography of the abdominal aorta and renal arteries.
OBJECTIVE
This study was conducted to determine the efficacy and safety of four different doses of gadobenate dimeglumine for contrast-enhanced three-dimensional MR angiography of the abdominal aorta and renal arteries.


METHODS
Ninety-four patients with suspected abnormality of the abdominal aorta or renal arteries underwent unenhanced three-dimensional gradient-recalled echo time-of-flight MR angiography and contrast-enhanced MR angiography after the IV injection of one of four doses of gadobenate dimeglumine (0.025, 0.05, 0.1, and 0.2 mmol/kg of body weight). Efficacy was assessed on-site and by two blinded off-site reviewers in terms of change in total diagnostic quality score and diagnostic quality score per vessel segment from baseline unenhanced time-of-flight MR angiography to contrast-enhanced MR angiography. Secondary efficacy end points included lesion count and level of confidence in lesion characterization. Safety assessments comprised adverse event monitoring, physical evaluation, vital signs, ECG, and laboratory investigations.


RESULTS
A significant change in the total diagnostic quality score from unenhanced to contrast-enhanced MR angiography was observed at all doses. The change increased with increased dose, plateauing at the 0.1 mmol/kg dose level. More patients with lesions detected and increased reviewer confidence for lesion characterization were noted on contrast-enhanced MR angiography compared with unenhanced MR angiography, although no dose-related trends were observed. All doses were well tolerated, and no significant changes in safety parameters were observed.


CONCLUSIONS
Gadobenate dimeglumine is an effective and safe agent for contrast-enhanced MR angiography of the abdominal aorta and renal arteries. A dose of 0.1 mmol/kg of body weight appears to be the most suitable.
Kroencke
Thomas J
TJ
Department of Radiology, Universitätsklinikum Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin, Schumannstr. 20/21, 10098 Berlin, Germany.
Wasser
Martin N
MN
Pattynama
Peter M T
PM
Barentsz
Jelle O
JO
Grabbe
Eckhardt
E
Marchal
Guy
G
Knopp
Michael V
MV
Schneider
Günther
G
Bonomo
Lorenzo
L
Pennell
Dudley J
DJ
del Maschio
Alessandro
A
Hentrich
Hans-Rainer
HR
Daprà
Massimo
M
Kirchin
Miles A
MA
Spinazzi
Alberto
A
Taupitz
Matthias
M
Hamm
Bernd
B
D000328:Adult; D000368:Aged; D001012:Aorta, Abdominal / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D021621:Imaging, Three-Dimensional; D007275:Injections, Intravenous; D018810:Magnetic Resonance Angiography; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000009:adverse effects; D012077:Renal Artery / Q000473:pathology*
D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium