Cerebellar abiotrophy in a family of Border Collie dogs.
Cerebellar abiotrophies have a nonsex-linked, autosomal, recessively inherited basis in a number of species, and lesions typically reflect profound and progressive loss of Purkinje cells. In this report, an unusual form of abiotrophy is described for two sibling Border Collies. Extensive loss of the cerebellar granular cell layer was present with relative sparing of Purkinje cells of two female pups. The biochemical basis for this form of cerebellar abiotrophy is unknown, but the lack of disease in other siblings supports an autosomal recessive mode of inheritance.
Sandy
J R
JR
School of Veterinary Science, University of Melbourne, Australia. j.sandy@unimelb.edu.au
Slocombe
R E
RE
Mitten
R W
RW
Jedwab
D
D
D000818:Animals; D001284:Atrophy / Q000473:pathology / Q000662:veterinary; D002526:Cerebellar Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D009475:Neurons, Afferent / Q000473:pathology; D011689:Purkinje Cells / Q000473:pathology