Synthesis of RGD containing peptides and their bioactivities.
RGDS, RGDV, and RGDF were used for the structural modification of YIGSR and YIGSK, the sequences involved in the development of metastasis disease. By use of a solution method, YIGSRRGDS, YIGSRRGDV, YIGSRRGDF, YIGSKRGDS, YIGSKRGDV, YIGSKRGDF, YIGSRYIGSK, and YIGSKYIGSR were prepared in good yield. The results of bioassay in vitro indicated that the target property of RGDS, RGDV, and RGDF to high affinity-receptors may be responsible for the enhanced anti-aggregation, anti-adhesion, and anti-invasion potency.
Zhao
Ming
M
College of Pharmaceutical Chemistry, Peking University, Beijing 100083, PR China.
Wang
Chao
C
Jiang
Xiurong
X
Pen
Shiqi
S
D001792:Blood Platelets / Q000378:metabolism; D002449:Cell Aggregation / Q000502:physiology; D066298:In Vitro Techniques; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism; D009842:Oligopeptides / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis* / Q000378:metabolism; D010974:Platelet Aggregation / Q000502:physiology
D009842:Oligopeptides; D010455:Peptides; C047981:arginyl-glycyl-aspartic acid