title: Effect of insulin-like growth factor-I (IGF-I) on femoral bone modeling in growing mice.
abstract: The time-dependent effects of daily dosing of IGF-I (1.21 mg/g) on the linear growth of the femur were investigated in mice. The femoral length and volume and the number of osteoclasts were significantly greater after IGF-I injection as compared to the non-injected control, suggesting that the IGF-I imbalance might cause a quick turnover cycle of the bone resulting in the altered femoral modeling.
authors.affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Kawata
authors.forename: Chiyoko
authors.initials: C
authors.lastname: Tokimasa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Fujita
authors.forename: Masato
authors.initials: M
authors.lastname: Kaku
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Shinya
authors.initials: S
authors.lastname: Kohno
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuki
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tenjo
authors.forename: Junji
authors.initials: J
authors.lastname: Ohtani
authors.forename: Masahide
authors.initials: M
authors.lastname: Motokawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayakawa
authors.forename: Mao
authors.initials: M
authors.lastname: Shigekawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanne
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000166:cytology / Q000254:growth & development*; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D007334:Insulin-Like Growth Factor I