Cyclin destruction in mitosis: a crucial task of Cdc20.
Proteolytic destruction of cyclins is a fundamental process for cell division. At the end of mitosis, degradation of mitotic cyclins results in the inactivation of cyclin-dependent kinases. Cyclin proteolysis is triggered by the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit complex which contains ubiquitin ligase activity. Recent data in yeast demonstrated that a partial degradation of the mitotic cyclin Clb2, mediated by APC/C and its activator protein Cdc20, is essential and sufficient for the mitotic exit. Remarkably, a complete inactivation of cyclin-dependent kinases seems to be not essential. This review discusses recent novel insights into cyclin destruction and its implications for the mitotic exit.
Irniger
Stefan
S
Institute of Microbiology and Genetics, Georg-August-University, Grisebachstr. 8, D-37077 Göttingen, Germany. sirnige@gwdg.de
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D064199:Cdc20 Proteins; D064200:Cdh1 Proteins; D018797:Cell Cycle Proteins / Q000502:physiology*; D019926:Cyclin B / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism*; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology*; D008938:Mitosis; D008954:Models, Biological; D017027:Protein Tyrosine Phosphatases; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology
C074860:CDC14 protein, S cerevisiae; C577495:CDC20 protein, S cerevisiae; C093749:CLB2 protein, S cerevisiae; D064199:Cdc20 Proteins; D064200:Cdh1 Proteins; D018797:Cell Cycle Proteins; C503698:CycB protein, Drosophila; D019926:Cyclin B; D016213:Cyclins; D029721:Drosophila Proteins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D016203:CDC2 Protein Kinase; D017027:Protein Tyrosine Phosphatases