Nerve entrapment and gene therapy.
Peripheral entrapment neuropathy is a common cause of upper-extremity pain, paresthesias, and weakness. Although any of the major nerves can be affected, compression of the median nerve at the carpal tunnel is the commonest site of clinically significant nerve compression. Etiologically, carpal tunnel syndrome (CTS) has numerous causes, but the idiopathic group greatly outnumbers the rest. Moreover, the pathophysiology of CTS patients claiming work-related repetitive hand motion as a basis for their disorder has been the subject of intensive study because of its economic ramifications for industry. CTS can serve as a model for reviewing the pathophysiology and biochemical changes of the nerve and its exterior milieu at the cellular level, as well as the possibilities of modifying these changes at the molecular level.
Sud
Vipul
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Division of Plastic Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
D002349:Carpal Tunnel Syndrome / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005544:Forecasting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D008297:Male; D009408:Nerve Compression Syndromes / Q000175:diagnosis / Q000628:therapy; D009416:Nerve Regeneration / Q000502:physiology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016896:Treatment Outcome