HLA-B27 and the pathogenesis of spondyloarthritis.
The association of HLA-B27 with ankylosing spondylitis and other spondyloarthropathies ranks among the strongest between any HLA antigen and a human disease. Yet, in spite of intense research and advanced knowledge of the biochemistry and biology of major histocompatibility complex molecules, the mechanism of this association remains unknown. This review attempts a critical assessment of current pathogenetic hypotheses from evidence concerning the epidemiology of HLA-B27 association with disease, its peptide-binding specificity, and other aspects of the molecular biology and immunology of this molecule.
Ramos
M
M
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Facultad de Ciencias, Madrid, Spain.
López de Castro
J A
JA
D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D025241:Spondylarthritis / Q000209:etiology* / Q000235:genetics*
D015796:HLA-B27 Antigen