Exocytosis: the chromaffin cell as a model system.
Neurons and neuroendocrine cells release transmitters and hormones by exocytosis of secrctory vesicles or granules. Among the cell models that have provided insight into the molecular machinery underlying the successive steps of exocytosis, adrenal chromaffin cells have taken a prominent place. Thus, most of the molecular players that orchestrate the formation, targeting, docking, and fusion of secrctory granules have been identified in chromaffin cells. By offering the opportunity to combine the use of recent biophysical techniques allowing single-vesicle resolution and specific biochemical modifications in the protein machinery involved in exocytosis, chromaffn cells remain a powerful model to address new and still open questions in the field of secretion.
Bader
Marie-France
MF
CNRS UPR-2356 Neurotransmission et Sécrétion Neuroendocrine, 67084 Strasbourg cedex, France. Barder@neurochem.u-strasbg.fr
Holz
Ronald W
RW
Kumakura
Konosuke
K
Vitale
Nicolas
N
D000199:Actins / Q000378:metabolism; D000818:Animals; D019439:Chromaffin Cells / Q000378:metabolism / Q000502:physiology*; D005089:Exocytosis; D011485:Protein Binding; D015398:Signal Transduction
D000199:Actins