Molecular typing of Mycobacterium tuberculosis strains with a common two-band IS6110 pattern.
We conducted a program of population-based molecular typing of all Mycobacterium tuberculosis isolates obtained in Alabama since 1994. Of 2452 isolates, 1013 (41%) had fewer than 6 bands of IS6110; 348 (14%) had a single two-band pattern (JH2). With conventional epidemiologic methods, we identified three groups of related patients with JH2 isolates. Spoligotyping and pattern of variable number of tandem repeats identified 10 molecular groups; two found by conventional methods were subdivided.
Lok
Kerry H
KH
University of Alabama School of Medicine, Birmingham, Alabama 35294-0022, USA.
Benjamin
William H
WH
Kimerling
Michael E
ME
Pruitt
Virginia
V
Mulcahy
Donna
D
Robinson
Nancy
N
Keenan
Nancy B
NB
Dunlap
Nancy E
NE
D000407:Alabama / Q000453:epidemiology; D015373:Bacterial Typing Techniques; D016172:DNA Fingerprinting; D024881:Drug Resistance, Bacterial; D014644:Genetic Variation; D006801:Humans; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology*