title: Periodontal therapy using local delivery of antimicrobial agents.
abstract: Antimicrobial agents, systemic and/or local, are thought by some to be effective agents for treating periodontal infections. Here the authors determine the costs and benefits of local delivery agents for treating periodontal disease. Applying this cost-benefit analysis to patient care, however, will depend upon a clinician's expertise and a patient's value system.
authors.affiliation: Center for Evidence-Based Dentistry, Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA. rniederman@forsyth.org
authors.forename: Richard
authors.initials: R
authors.lastname: Niederman
authors.forename: George
authors.initials: G
authors.lastname: Abdelshehid
authors.forename: J Max
authors.initials: JM
authors.lastname: Goodson
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000191:economics; D000890:Anti-Infective Agents / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002482:Cellulose / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003362:Cost-Benefit Analysis; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017277:Drug Approval; D016527:Drug Costs; D016503:Drug Delivery Systems / Q000191:economics; D005782:Gels / Q000008:administration & dosage; D005989:Glycerides / Q000008:administration & dosage; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008863:Microspheres; D008911:Minocycline / Q000008:administration & dosage; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000382:microbiology; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018570:Risk Assessment; D012715:Sesame Oil / Q000008:administration & dosage; D013752:Tetracycline / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: C116585:Actisite; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; C094288:Elyzol Dentalgel; D005782:Gels; D005989:Glycerides; D008795:Metronidazole; D012715:Sesame Oil; D002482:Cellulose; D013752:Tetracycline; D008911:Minocycline; C010882:chlorhexidine gluconate; D004318:Doxycycline; D002710:Chlorhexidine