Synthetic studies of cis-4-Amino-L-proline derivatives as novel lipid lowering agents.
cis-4-Amino-L-proline derivatives 1 and 2 derived from quinazolinone and pyrazolo pyrimidone respectively were designed as novel lipid lowering agents. A preliminary in vivo screening indicates that 1b and 2a have moderate triglyceride lowering activity.
Das
Saibal Kumar
SK
Discovery Chemistry, Dr. Reddy's Discovery Research, Bollaram Road, Miyapur, Hyderabad 500050, India. saibalkumardas@drreddys.com
Narasimha Rao Krovvidi
V L
VL
Jagadheshan
H
H
Iqbal
Javed
J
D000818:Animals; D015228:Hypertriglyceridemia / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011744:Pyrimidinones / Q000737:chemistry; D011799:Quinazolines / Q000737:chemistry; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D011744:Pyrimidinones; D011799:Quinazolines; D014280:Triglycerides; D011392:Proline