Protein kinase CK2 and regulation of Ca2+-ATPase activity in brain neuron chromatin in rats during aging.
Protein kinase CK2 from neuronal chromatin phosphorylates myosin-like proteins isolated from rat brain chromatin. The protein kinase CK2 activator 1-ethyl-4,5-di(N-methylcarbamoyl)imidazole in vitro stimulated phosphorylation of myosin-like proteins and increased myosin-type Ca(2+)-ATPase activity in neuronal chromatin. After systemic administration this agent normalized Ca(2+)-ATPase activity of brain chromatin in aged rats.
Reikhardt
B A
BA
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Kulikova
O G
OG
Sapronov
N S
NS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D047390:Casein Kinase II; D002843:Chromatin / Q000201:enzymology / Q000378:metabolism*; D004789:Enzyme Activation; D008297:Male; D009474:Neurons / Q000201:enzymology / Q000378:metabolism; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051381:Rats
D002843:Chromatin; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases; D000252:Calcium-Transporting ATPases