Stereocartography: a computational mapping technique that can locate regions of maximum stereoinduction around chiral catalysts.
A hypothesis concerning asymmetric induction by chiral catalysts is posited, tested, and found to be valid. The hypothesis states that chiral catalysts that are efficient at inducing asymmetry will have their region of maximum stereoinduction spatially congruent with the site of chemistry but inefficient catalysts will not. A simple mapping strategy (stereocartography) is used to assess where the region of maximum stereoinduction is located around a given catalyst. The protocol compares interaction energies between mirror image probes at each point in space around the catalyst being considered. The probes are models of the actual transition states of the reaction being catalyzed by a particular catalyst. The hypothesis was tested on three Diels-Alder reactions. Seventeen of the eighteen catalysts conform to the hypothesis. The idea of using this as a catalyst design tool is presented.
Lipkowitz
Kenny B
KB
Department of Chemistry, Indiana University-Purdue University at Indianapolis (IUPUI), 402 N. Blackford Street, Indianapolis, IN 46202, USA. lipkowitz@chem.iupui.edu
D'Hue
Cedric A
CA
Sakamoto
Taka
T
Stack
Jonathan N
JN
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D008958:Models, Molecular; D013237:Stereoisomerism