title: [Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000].
abstract: The report deals with the results of application of an original protocol--the Berlin-Moscow-91 (BM-91)--for the treatment of acute lymphoblastic leukemia (ALL) in children. The researchers' major concern was to improve survival and cut down side-effects incidence as well as to prevent and successfully manage occult neuroleukemia as a potential source of relapse. Patients aged 5 months-15 years received the BM-91 and ALL BFM-90m treatment first at one clinic and later at several centers. Out of 852 children with primary diagnosis of ALL admitted to Russian hematological hospitals (March 2, 1991-November 3, 2000), 687 were included into the study; 329 received the MB-91 protocol. Nine-year recurrence-free survival was 73% while overall survival--80%. Toxic side-effects after L-asparaginase were reported in 27 (7.9%). It is concluded that good results in childhood ALL treatment can be achieved without resorting to high-dosage chemotherapy and radiation in most cases.
authors.affiliation: Research Institute of Pediatric Hematology and Oncology, Ministry of Health of the RF, Russian Children's Clinical Hospital, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Miakova
authors.forename: R
authors.initials: R
authors.lastname: Hartmann
authors.forename: A E
authors.initials: AE
authors.lastname: Rudneva
authors.forename: N M
authors.initials: NM
authors.lastname: Trubina
authors.forename: L G
authors.initials: LG
authors.lastname: Fechina
authors.forename: A M
authors.initials: AM
authors.lastname: Timakov
authors.forename: A V
authors.initials: AV
authors.lastname: Shamardina
authors.forename: V V
authors.initials: VV
authors.lastname: Lebedev
authors.forename: S R
authors.initials: SR
authors.lastname: Varfolomeeva
authors.forename: S D
authors.initials: SD
authors.lastname: Dudkin
authors.forename: Z M
authors.initials: ZM
authors.lastname: Dyshlevaia
authors.forename: V N
authors.initials: VN
authors.lastname: Timofeeva
authors.forename: A G
authors.initials: AG
authors.lastname: Rumiantsev
authors.forename: H
authors.initials: H
authors.lastname: Henze
authors.forename: A I
authors.initials: AI
authors.lastname: Karachunskiĭ
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D001215:Asparaginase / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000008:administration & dosage; D003627:Data Interpretation, Statistical; D003630:Daunorubicin / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D009031:Moscow; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000401:mortality; D012074:Remission Induction; D012307:Risk Factors; D012426:Russia; D016019:Survival Analysis; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D000972:Antineoplastic Agents, Phytogenic; D003561:Cytarabine; D014750:Vincristine; D003907:Dexamethasone; D015122:Mercaptopurine; D001215:Asparaginase; D008727:Methotrexate; D003630:Daunorubicin