Morphogenesis of the branchial vascular sector.
The branchial and dorsal cephalic vascular sectors correspond to the blood vessels contained within evolutionarily recent and ancestral parts of the head, respectively. Recent work demonstrates that neural crest cells (NCCs) provide the pericytes, and connective and smooth muscle cells to the entire branchial sector in an ordered fashion. Initial NCC position is transposed to the vascular distal-to-proximal axis, explaining why circumscribed cephalic vascular anomalies are often associated with reproducible malformations in head tissues derived from the neural crest. Unlike the rest of the central nervous system, the forebrain requires mesenchyme-containing vascular-competent NCCs to survive during embryogenesis and beyond.
Etchevers
Heather C
HC
Institute of Cellular and Molecular Embryology, College of France, Nogent-sur-Marne, France.
Couly
Gérard
G
Le Douarin
Nicole M
NM
D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D001921:Brain / Q000098:blood supply / Q000196:embryology* / Q000254:growth & development*; D001934:Branchial Region / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D020785:Central Nervous System Vascular Malformations / Q000196:embryology / Q000503:physiopathology; D003238:Connective Tissue / Q000196:embryology / Q000254:growth & development; D006801:Humans; D009024:Morphogenesis / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D009432:Neural Crest / Q000166:cytology / Q000196:embryology / Q000254:growth & development