title: Corneal opacifications in a low high density lipoprotein syndrome: suspicion of fish eye disease: a case report.
abstract: A 49 year old patient with progressive massive bilateral corneal opacifications associated with a HDL (high-density-lipoprotein) deficiency is described. The opacifications started at the age of twenty and progressed slowly. They were found diffusely over the cornea, though more in the corneal periphery. A penetrating keratoplasty at the right eye was performed. The diagnosis of Fish Eye Disease was put forward on the basis of the ophthalmological, clinical, biochemical and pathological appearance. After 2 year follow-up, the graft was clear. The final distance and near vision of the right eye was 8/10 and Snellen 1 respectively.
authors.affiliation: Department of Ophthalmology, Katholieke Universiteit Leuven, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: De Smedt
authors.forename: R
authors.initials: R
authors.lastname: Van Ginderdeuren
authors.forename: R
authors.initials: R
authors.lastname: De Vos
authors.forename: A
authors.initials: A
authors.lastname: Mertens
authors.forename: E
authors.initials: E
authors.lastname: Muls
authors.forename: B
authors.initials: B
authors.lastname: Foets
mesh_terms: D000328:Adult; D003318:Corneal Opacity / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008875:Middle Aged; D013631:Tangier Disease / Q000150:complications* / Q000175:diagnosis*