title: [The change in apoptosis and proliferation of pulmonary tissue cells in rats with smoke inhalation injury].
abstract: OBJECTIVE
  To observe the rule of the change of apoptosis and proliferation of pulmonary tissue cells in rats with inhalation injury, so as to explore the significance of apoptosis in the repairing process of pulmonary tissue injury.
  
  
  METHODS
  Smoke inhalation injury model was established in rats. The rats were randomly divided into normal control (NC) and smoke inhalation injury (SI) groups. TUNEL and immunohistochemistry methods were employed to determine the changes in cellular apoptotic and proliferating cell nuclear antigen (PCNA) indices of the pulmonary tissue at different postburn time points.
  
  
  RESULTS
  (1) The apoptotic index increased at 2 postburn hours (PBHs) and remained at high levels thereafter. (2) The PCNA index increased at 12 PBHs, reaching top level at 3 postburn days (PBDs), remaining kept at relativly high level later.
  
  
  CONCLUSIONS
  Apoptosis not only played roles in the early pulmonary injury after smoke inhalation injury, but also participated in the repair and modification of the proliferated tissue during later reconstruction.
authors.affiliation: Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P.R. China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Li
authors.forename: Zongcheng
authors.initials: Z
authors.lastname: Yang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yang
authors.forename: Tianpeng
authors.initials: T
authors.lastname: Ji
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Erhong
authors.initials: E
authors.lastname: Li
authors.forename: Guanghe
authors.initials: G
authors.lastname: Zhao
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000473:pathology*; D008297:Male; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015208:Smoke Inhalation Injury / Q000378:metabolism / Q000473:pathology*
chemical_list: D018809:Proliferating Cell Nuclear Antigen