Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy.
Biomechanical signaling is a complex interaction of both intracellular and extracellular components. Both passive and active components are involved in the extracellular environment to signal through specific receptors to multiple signaling pathways. This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy.
Sussman
Mark A
MA
Children's Hospital and Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, Ohio, USA.
McCulloch
Andrew
A
Borg
Thomas K
TK
D000818:Animals; D001696:Biomechanical Phenomena; D002118:Calcium / Q000378:metabolism; D006332:Cardiomegaly / Q000473:pathology / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020935:MAP Kinase Signaling System; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D011956:Receptors, Cell Surface; D002118:Calcium