title: Childhood vaccine purchase costs in the public sector: past trends, future expectations.
abstract: OBJECTIVE
  We examined recent public-sector trends in childhood vaccine costs and estimated future costs.
  
  
  METHODS
  We used public-sector price data to calculate vaccine purchase cost per child for children aged 0 to 6 years from 1975 to 2001. We fit a linear regression model to historical data and then used it to project costs per child from 2002 to 2020, adjusted to 2001 US dollars.
  
  
  RESULTS
  Controlling for inflation, the cost of vaccine purchase per child climbed from $10 in 1975 to $385 in 2001. The cost of vaccine purchase in the year 2020 following recommendation of 7 additional vaccines is estimated to be $1225 per child (95% confidence interval = $891, $1559).
  
  
  CONCLUSIONS
  The cost per child for recommended vaccines at public-sector prices may triple over the next 2 decades. These projections have implications for vaccine financing at federal and state levels.
authors.affiliation: Child Health Evaluation and Research (CHEAR) Unit, Division of General PediatricsUniversity of Michigan, Ann Arbor 48109, USA. mattdav@umich.edu
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Davis
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Zimmerman
authors.forename: John R C
authors.initials: JR
authors.lastname: Wheeler
authors.forename: Gary L
authors.initials: GL
authors.lastname: Freed
mesh_terms: D002648:Child; D016527:Drug Costs / Q000639:trends*; D006801:Humans; D017589:Immunization Programs / Q000191:economics* / Q000639:trends; D007223:Infant; D007231:Infant, Newborn; D017149:Private Sector; D017150:Public Sector; D012189:Retrospective Studies; D014481:United States; D014612:Vaccines / Q000191:economics*
chemical_list: D014612:Vaccines