Relationship between CAG repeat length and late-stage outcomes in Huntington's disease.
The relationship between CAG repeat length and age at nursing home (NH) admission and age at percutaneous endoscopic gastrostomy (PEG) was examined in 47 residents of a specialized Huntington's disease long-term care facility who were observed for a median of 3 years (range, 1 to 11 years). CAG repeat length was inversely correlated with time to NH admission and PEG (both p < 0.001), independent of age at onset. CAG repeat length may influence disease progression to late-stage outcomes in addition to age at onset.
Marder
K
K
Department of Neurology, Sergievsky Center, and The Taub Institute, Columbia University, New York, NY 10032, USA. ksm1@columbia.edu
Sandler
S
S
Lechich
A
A
Klager
J
J
Albert
S M
SM
D000328:Adult; D000368:Aged; D018450:Disease Progression; D004724:Endoscopy; D005260:Female; D005774:Gastrostomy; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes; D012044:Regression Analysis; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D016019:Survival Analysis; D015431:Weight Loss / Q000502:physiology