One-pot three-component reaction for the synthesis of alpha-(aminoethyl)-alpha,beta-enones.
[reaction: see text] The synthesis of alpha-substituted alpha,beta-enones by a new metal iodide-promoted one-pot three-component reaction involving commercially available cyclopropyl ketones, aldehydes, and secondary amines followed by base treatment is described.
Bertozzi
Fabio
F
Discovery Chemistry, ACADIA Pharmaceuticals A/S, Fabriksparken 58, DK-2600 Glostrup, Denmark.
Gustafsson
Magnus
M
Olsson
Roger
R