Delta sleep-inducing peptide blocks excitatory effects of glutamate on rat brain neurons.
Microiontophoresis of delta sleep-inducing peptide primarily activated neurons in the dorsal hippocampus, anteroventral thalamic nucleus, lateral hypothalamus, and sensorimotor cortex. Microiontophoretic administration of glutamate markedly enhanced neuronal activity, while preliminary microionophoresis of delta sleep-inducing peptide blocked the excitatory effect of glutamate on neurons in these brain structures.
Umriukhin
P E
PE
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004594:Electrophysiology; D018698:Glutamic Acid / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D009044:Motor Cortex / Q000187:drug effects; D009474:Neurons / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D010455:Peptides; D018698:Glutamic Acid; D003701:Delta Sleep-Inducing Peptide