title: Identifying the sources of tuberculosis in young children: a multistate investigation.
abstract: To better understand the molecular epidemiology of tuberculosis (TB) transmission for culture-confirmed patients <5 years of age, data were analyzed from a population-based study conducted in seven U.S. sites from 1996 to 2000. Mycobacterium tuberculosis isolates were genotyped with IS6110-based restriction fragment length polymorphism analysis and spoligotyping. Case-patient data were obtained from the Centers for Disease Control and Prevention s national tuberculosis registry and health department records. Routine public health investigations conducted by local health departments identified suspected source patients for 57 (51%) of 111 culture-confirmed patients <5 years of age. For 8 (15%) of 52 culture-confirmed patients <5 years of age and their suspected source patients with complete genotyping results, genotypes suggested infection with different TB strains. Potential differences between sources for patients <5 years of age and source patients that transmitted TB to adolescent and adult patients were identified.
authors.affiliation: California Department of Health Services, Berkley, CA, USA. ssun1@dhs.ca.gov
authors.forename: Sumi J
authors.initials: SJ
authors.lastname: Sun
authors.forename: Diane E
authors.initials: DE
authors.lastname: Bennett
authors.forename: Jennifer
authors.initials: J
authors.lastname: Flood
authors.forename: Ann M
authors.initials: AM
authors.lastname: Loeffler
authors.forename: Steve
authors.initials: S
authors.lastname: Kammerer
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Ellis
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000032:analysis; D016208:Databases, Factual; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D018571:Sentinel Surveillance; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission*; D014481:United States / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial