title: Multiple palmar epidermoid cysts.
abstract: Implantation of epidermal fragments into the dermis has been pointed out as the cause of common epidermal cysts. However, some palmoplantar epidermoid cysts have been reported to be caused by human papillomavirus (HPV) infection or to be derived from eccrine ducts. A 65-year-old left-handed woman presented with extraordinary multiple epidermoid cysts on the palm and volar aspect of the fingers of her left hand. HPV infection was not detected by immunohistochemistry, in situ hybridization and polymerase chain reaction. Histological investigation revealed syringeal structures within the cyst wall and in the cyst cavity. Carcinoembryonic antigen was observed in these syringeal structures but was not specifically stained in the cyst wall cells by immunohistochemistry. The cytokeratin composition of the cyst wall cells was similar to that of the nonadnexal epidermis.
authors.affiliation: Department of Dermatology, Kochi Medical School, Nankoku, Kochi, Japan. yokogawa@kochi-ms.ac.jp
authors.forename: Maki
authors.initials: M
authors.lastname: Yokogawa
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Egawa
authors.forename: Kumi
authors.initials: K
authors.lastname: Dabanaka
authors.forename: Emi
authors.initials: E
authors.lastname: Wada
authors.forename: Ken
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Ikeda
authors.forename: Yumi
authors.initials: Y
authors.lastname: Honda
authors.forename: Hidero
authors.initials: H
authors.lastname: Kitasato
authors.forename: Hajime
authors.initials: H
authors.lastname: Kodama
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D004814:Epidermal Cyst / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006229:Hand Dermatoses / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D018570:Risk Assessment; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology*; D014412:Tumor Virus Infections / Q000175:diagnosis*