Neurotrophins and the control of axonal outgrowth.
The neurotrophins NGF, BDNF, NT-3, and NT-4/5 are well known for their neuron survival-promoting functions. This review focuses upon a less-investigated function of this gene family, namely that of controlling the growth of axons in vivo. Recent evidence is discussed that reveals a definitive requirement for neurotrophin signaling in the elongation of peripheral nerves during embryonic development.
Tucker
K L
KL
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. klt@fmi.ch
D000818:Animals; D001369:Axons / Q000502:physiology*; D009414:Nerve Growth Factors / Q000378:metabolism*; D009420:Nervous System / Q000254:growth & development
D009414:Nerve Growth Factors