title: Skin cancer induced by arsenic in the water.
abstract: BACKGROUND
  Arsenic (As) is a well-recognized poison. Exposure may be of an acute nature, leading to high concentrations and acute arsenic poisoning. Chronic exposure may lead to benign skin changes, skin cancer, and internal malignancy.
  
  
  OBJECTIVE
  Our purpose was to study the nature, incidence, and sequelae of skin disorders in a group of Argentinean patients suffering from chronic arsenicism due to the intake of contaminated well water.
  
  
  METHODS
  All patients who presented with chronic arsenicism at the Dermatology Department of Hospital Posadas (Buenos Aires, Argentina) during a 10-year period (1988-1998) were included in this study. The patient group compromised 9 women and 14 men, the age range was 37-72 years. Diagnosis was based on the clinical triad (keratoderma, leucoderma and epiteliomatosis). We performed clinical, laboratory, and histopathologic studies to confirm diagnosis. We screened for possible internal diseases.
  
  
  RESULTS
  All patients included in this study had cutaneous lesions associated with long-term arsenic exposure. The mean age of the patients was 58.2 years. The estimated mean time of the beginning of the lesions was of 3.7 years. All patients were Argentinean from endemic areas of our country where the arsenic levels are higher than those accepted by the World Health Organization.
  
  
  CONCLUSIONS
  This study allows us to conclude that the relationship between arsenic and cancer is frequent and it describes the principal characteristics of this entity in our group of patients.
authors.affiliation: Dermatology Department, Hospital Posadas, School of Medicine, Buenos Aires University, Argentina.
authors.forename: Hugo Néstor
authors.initials: HN
authors.lastname: Cabrera
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Gómez
mesh_terms: D020261:Arsenic Poisoning / Q000150:complications*; D002280:Basal Cell Carcinoma / Q000139:chemically induced*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005260:Female; D006801:Humans; D007642:Keratosis / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000139:chemically induced*; D014874:Water Pollutants, Chemical / Q000009:adverse effects*; D014881:Water Supply
chemical_list: D014874:Water Pollutants, Chemical