title: Job characteristics and blood coagulation factors in Korean male workers.
abstract: This study examined the possible relationship between Karasek's job strain model and blood coagulation factors VII and VIII as risk factors for cardiovascular disease in Korean male workers. Based on the postulation of the model, we invited 160 male workers (40 people each subgroup) using a stratified sampling from the base population (n = 1071). In univariate analyses, decision latitude was negatively related to blood coagulation factors VII and VIII. Work demand was positively related to coagulation factor VIII, but not to factor VII. Hierarchical multiple regression analyses showed that job strain was associated with blood coagulation factor VIII after controlling for smoking, blood pressure, total cholesterol, and HDL cholesterol. These results indicate that job characteristics may be related to blood coagulation, and contribute to the development of cardiovascular disease with other classical risk factors.
authors.affiliation: Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University, Wonju, Gangwondo 220-701, South Korea. chang@wonju.yonsei.ac.kr
authors.forename: Sei Jin
authors.initials: SJ
authors.lastname: Chang
authors.forename: Sang Baek
authors.initials: SB
authors.lastname: Koh
authors.forename: Bong Suk
authors.initials: BS
authors.lastname: Cha
authors.forename: Jong Ku
authors.initials: JK
authors.lastname: Park
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001779:Blood Coagulation Factors / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology; D015331:Cohort Studies; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D006801:Humans; D007587:Job Description; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology*; D011336:Probability; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D013315:Stress, Psychological
chemical_list: D001779:Blood Coagulation Factors; D005167:Factor VII; D005169:Factor VIII