title: Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice.
abstract: BACKGROUND
  Self-administration studies have suggested that dopamine (DA) is important for the reinforcing effects of ethanol. However, ethanol place conditioning studies have less consistently demonstrated a role for DA in conditioned place preference.
  
  
  OBJECTIVE
  The purpose of the present study was to determine whether blockade of D(1), D(2) or D(3) DA receptors would impact the expression of the conditioned place preference induced by ethanol in DBA/2J mice.
  
  
  METHODS
  Mice underwent an unbiased place conditioning procedure with 2 g/kg ethanol. Prior to the preference test, mice were injected i.p. with SCH23390 (0, 0.015 or 0.03 mg/kg), raclopride (0, 0.3 or 0.6 mg/kg) or U99194A (0, 10 or 20 mg/kg).
  
  
  RESULTS
  Ethanol produced a significant conditioned place preference that was not affected by any of the dopamine antagonists tested. Each of the antagonists decreased locomotor activity, though U99194A was minimally effective.
  
  
  CONCLUSIONS
  These findings suggest that the conditioned reinforcing effects of ethanol in DBA/2J mice as assessed by place conditioning are mediated by non-dopaminergic mechanisms.
authors.affiliation: Psychology Department, Amherst College, P.O. Box 5000, Amherst, MA 01002-5000, USA. sddickinson@amherst.edu
authors.forename: Shelly D
authors.initials: SD
authors.lastname: Dickinson
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Lee
authors.forename: Kirsten
authors.initials: K
authors.lastname: Rindal
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Cunningham
mesh_terms: D000818:Animals; D001245:Association Learning / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D007189:Indans / Q000494:pharmacology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009042:Motivation; D009043:Motor Activity / Q000187:drug effects*; D020891:Raclopride / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D007189:Indans; D011954:Receptors, Dopamine; C086335:(5,6-dimethoxyindan-2-yl)dipropylamine; D000431:Ethanol; D020891:Raclopride