title: Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger.
abstract: Artemisinin (1) was transformed by Mucor polymorphosporus and Aspergillus niger. Five products were identified as 9beta-hydroxyartemisinin (2), 3beta-hydroxyartemisinin (3), deoxyartemisinin (4), 3beta-hydroxydeoxyartemisinin (5), and 1alpha-hydroxydeoxyartemisinin (6). Products 2, 3, and 6 are new compounds.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China.
authors.forename: Ji-Xun
authors.initials: JX
authors.lastname: Zhan
authors.forename: Yuan-Xing
authors.initials: YX
authors.lastname: Zhang
authors.forename: Hong-Zhu
authors.initials: HZ
authors.lastname: Guo
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Ning
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D037621:Artemisinins / Q000378:metabolism*; D001234:Aspergillus niger / Q000378:metabolism*; D002384:Catalysis; D002681:China; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism*
chemical_list: D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin