title: The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice.
abstract: Despite the effectiveness of the selective estrogen receptor (ER) modulators in preventing ER-positive breast cancer, chemopreventive agents still need to be developed for the prevention of ER-negative breast cancers. The naturally occurring retinoids are promising agents for the prevention of human cancers but are too toxic for long-term chronic use. We previously demonstrated that the chemopreventive effects of the retinoids could be separated from the toxicity by using an RXR-selective retinoid, LGD1069. The studies described here demonstrate that LGD1069 effectively suppresses ER-negative tumor development in mouse mammary tumor virus-erbB2 transgenic mice with minimal toxicity. These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer.
authors.affiliation: Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Kendall
authors.initials: K
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Xu
authors.forename: Jamal
authors.initials: J
authors.lastname: Hill
authors.forename: Joseph
authors.initials: J
authors.lastname: Celestino
authors.forename: Hee-Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Syed K
authors.initials: SK
authors.lastname: Mohsin
authors.forename: Susan G
authors.initials: SG
authors.lastname: Hilsenbeck
authors.forename: William W
authors.initials: WW
authors.lastname: Lamph
authors.forename: Reid
authors.initials: R
authors.lastname: Bissonette
authors.forename: Powel H
authors.initials: PH
authors.lastname: Brown
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000077610:Bexarotene; D002455:Cell Division / Q000187:drug effects; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D018734:Genes, erbB-2; D008321:Mammary Glands, Animal / Q000166:cytology / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008324:Mammary Tumor Virus, Mouse; D051379:Mice; D008822:Mice, Transgenic; D011960:Receptors, Estrogen / Q000502:physiology; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D047488:Retinoid X Receptors; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D014157:Transcription Factors / Q000378:metabolism*; D019076:Transgenes / Q000187:drug effects / Q000235:genetics
chemical_list: D016588:Anticarcinogenic Agents; D011960:Receptors, Estrogen; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D013764:Tetrahydronaphthalenes; D014157:Transcription Factors; D000077610:Bexarotene