HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.
By means of HIV gp41 binding affinity directed chromatographic fractionation, three phenylethanoid glycosides; calceolarioside A ( 1), calceolarioside B ( 2) and acteoside ( 3), along with four hydroxycoumarins; esculin ( 4), fraxin ( 5), fraxetin ( 6) and esculetin ( 7), and one lignan, (-)-olivil ( 8) were isolated from the n-butyl alcohol fraction of Fraxinus sieboldiana var. angustata. Among the isolated compounds, calceolarioside B ( 2) and esculetin ( 7) showed moderate binding affinity on HIV gp41 with IC 50 values of 0.1 mg/ml and 0.5 mg/ml, respectively. Calceolarioside A ( 1), calceolarioside B ( 2), acteoside ( 3), and (-)-olivil ( 8) were isolated for the first time from this plant.
Kim
Hyoung Ja
HJ
Yu
Yeon Gyu
YG
Park
Hokoon
H
Lee
Yong Sup
YS
D001667:Binding, Competitive; D002109:Caffeic Acids / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D004929:Esculin / Q000494:pharmacology; D031661:Fraxinus; D005960:Glucosides / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology*; D015700:HIV Envelope Protein gp41 / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D010636:Phenols / Q000494:pharmacology; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology; D059808:Polyphenols
D002109:Caffeic Acids; D003374:Coumarins; D004929:Esculin; D005960:Glucosides; D006027:Glycosides; D015700:HIV Envelope Protein gp41; D010636:Phenols; D010936:Plant Extracts; D014468:Umbelliferones; C058956:acteoside; D059808:Polyphenols; C083066:calceolarioside A; C105671:fraxetin; C007628:esculetin; C080614:fraxin