title: Reactive oxygen: its sources and significance in Alzheimer disease.
abstract: Over the past decade, oxidative stress has been established as the earliest cytological feature of Alzheimer disease and an attractive therapeutic target. The major challenges now are establishing the source of the reactive oxygen and what oxidative stress tells us about the etiology of Alzheimer disease. These are complex issues since a variety of enzymatic and non-enzymatic processes are involved in reactive oxygen formation and damage to macromolecules. In this review, we consider disease mechanisms that show the greatest promise for future research.
authors.affiliation: Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. gxp7@po.cwru.edu
authors.forename: G
authors.initials: G
authors.lastname: Perry
authors.forename: A
authors.initials: A
authors.lastname: Nunomura
authors.forename: A D
authors.initials: AD
authors.lastname: Cash
authors.forename: M A
authors.initials: MA
authors.lastname: Taddeo
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: G
authors.initials: G
authors.lastname: Aliev
authors.forename: J
authors.initials: J
authors.lastname: Avila
authors.forename: T
authors.initials: T
authors.lastname: Wataya
authors.forename: S
authors.initials: S
authors.lastname: Shimohama
authors.forename: C S
authors.initials: CS
authors.lastname: Atwood
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species