Clinicopathologic correlations of genomic gains and losses in follicular lymphoma.
OBJECTIVE
To evaluate the clinical relevance of genomic aberrations in follicular lymphomas (FLs).


METHODS
In this study, we analyzed 124 biopsy samples of patients with FL using comparative genomic hybridization.


RESULTS
In 87 cases (70%), genomic imbalances were detectable. The most frequent aberrations were gains of chromosome arms 7p (21 patients), 7q (21 patients), Xp (16 patients), 12q (15 patients), and 18q (14 patients) as well as losses on 6q (21 patients). Grades 2 and 3 according to the World Health Organization classification correlated with a more complex karyotype (P <.0001). In a subset of 82 patients, a comprehensive clinical data set was available. In a multivariate analysis including all clinical risk factors of the International Prognostic Index as well as genomic aberrations, the loss of material on chromosomal bands 6q25q27 was the strongest predictor of a shorter survival (P =.0001; hazard ratio, 6.5), followed by elevated serum lactate dehydrogenase level (P =.0009; hazard ratio, 4.9), the presence of more than one extranodal manifestation (P =.017; hazard ratio, 4.2), and age greater than 60 years (P =.022; hazard ratio, 2.6).


CONCLUSIONS
These data indicate that genomic aberrations may contribute significantly to risk assessment in patients with FL, the majority of whom are included in low-risk groups using established clinical prognostic scores.
Viardot
Andreas
A
Abteilung Innere Medizin III, Pathologie, and Biometrie und Medizinische Dokumentation, Universität Ulm, Germany.
Möller
Peter
P
Högel
Josef
J
Werner
Kirsten
K
Mechtersheimer
Gunhild
G
Ho
Anthony D
AD
Ott
German
G
Barth
Thomas F E
TF
Siebert
Reiner
R
Gesk
Stefan
S
Schlegelberger
Brigitte
B
Döhner
Hartmut
H
Bentz
Martin
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002887:Chromosomes, Human, Pair 18; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005629:Frozen Sections; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D014178:Translocation, Genetic; D014960:X Chromosome
D004273:DNA, Neoplasm; D007770:L-Lactate Dehydrogenase