Intrathecal morphine overdose during combined spinal-epidural block for Caesarean delivery.
We describe a 25 mg intrathecal morphine overdose during a combined spinal-epidural block for a Caesarean delivery. Naloxone infusion (5.24 mg over 24 h) was started prior to the patient becoming symptomatic and almost immediately after the overdose. Invasive therapeutics such as mechanical ventilation were avoided.
Cannesson
M
M
Service d'Anesthésie-Réanimation, Hôpital de l'Hôtel-Dieu, F-69002 Lyon, France.
Nargues
N
N
Bryssine
B
B
Debon
R
R
Boselli
E
E
Chassard
D
D
D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D000767:Anesthesia, Epidural / Q000379:methods; D000773:Anesthesia, Obstetrical / Q000379:methods*; D000775:Anesthesia, Spinal / Q000379:methods; D002585:Cesarean Section; D062787:Drug Overdose / Q000628:therapy; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008508:Medication Errors / Q000009:adverse effects; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D011247:Pregnancy
D000701:Analgesics, Opioid; D009020:Morphine