title: Further support for the association of CCR5 allelic variants with asthma susceptibility.
abstract: English and German nuclear families containing multiple asthmatic children and asthmatic parents were analysed to retest a recently reported association between resistance to asthma and the delta32 allele of chemokine receptor 5 (CCR5). Analysis of the families by the transmission-disequilibrium test (TDT) revealed a non-significant trend in the English families that provided marginal confirmation of the association (P < 0.125), but no similar trend was observed in the German families. Case-control comparison of delta32 allele and genotype frequencies in asthmatic vs. non-asthmatic parents revealed a significantly lower frequency of delta32 in asthmatic English parents (P < 0.009) and a similar but non-significant trend in German parents (P < 0.265). Taken together, the pattern of results provides confirmation for the previously observed delta32-asthma association and indicates that susceptibility to asthma may be influenced by CCR5 or another gene in chromosomal region 3p21.
authors.affiliation: GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK. Ralph_McInnis@sbphrd.com
authors.forename: R
authors.initials: R
authors.lastname: McGinnis
authors.forename: F
authors.initials: F
authors.lastname: Child
authors.forename: S
authors.initials: S
authors.lastname: Clayton
authors.forename: S
authors.initials: S
authors.lastname: Davies
authors.forename: W
authors.initials: W
authors.lastname: Lenney
authors.forename: T
authors.initials: T
authors.lastname: Illig
authors.forename: M
authors.initials: M
authors.lastname: Wjst
authors.forename: N
authors.initials: N
authors.lastname: Spurr
authors.forename: C
authors.initials: C
authors.lastname: Debouck
authors.forename: A H
authors.initials: AH
authors.lastname: Hajeer
authors.forename: W E R
authors.initials: WE
authors.lastname: Ollier
authors.forename: R
authors.initials: R
authors.lastname: Strange
authors.forename: A A
authors.initials: AA
authors.lastname: Fryer
mesh_terms: D000483:Alleles; D001249:Asthma / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics* / Q000502:physiology
chemical_list: D019713:Receptors, CCR5