Preparation of C8-amine and acetylamine adducts of 2'-deoxyguanosine suitably protected for DNA synthesis.
[reaction: see text] C8-Amine and acetylamine adducts of 2'-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2'-deoxyguanosine derivative, for the selective acetylation of the coupled adduct at N(8) and for a protecting group scheme preserving the integrity of the base-labile N(8) acetyl group during DNA synthesis.
Gillet
Ludovic C J
LC
Institute of Medical Radiobiology, University of Zürich, August Forel Str. 7, 8008 Zürich, Switzerland.
Schärer
Orlando D
OD
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D015394:Molecular Structure
D000588:Amines; D004247:DNA; D003849:Deoxyguanosine