title: Macrophage intracellular signaling induced by Listeria monocytogenes.
abstract: Macrophages are critical for control of Listeria monocytogenes infections; accordingly, the interactions of L. monocytogenes with these cells have been intensively studied. It has become apparent that this facultative intracellular pathogen interacts with macrophages both prior to entry and during the intracellular phase. This review covers recent work on signaling induced in macrophages by L. monocytogenes, especially intracellular signals induced by secreted proteins including listeriolysin O and two distinct phospholipases C.
authors.affiliation: Department of Microbiology University of Pennsylvania School of Medicine, Pennsylvania, PA 19104-6076, USA. goldfinh@mail.med.upenn.edu
authors.forename: Howard
authors.initials: H
authors.lastname: Goldfine
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Wadsworth
mesh_terms: D001427:Bacterial Toxins; D020013:Calcium Signaling; D006360:Heat-Shock Proteins / Q000378:metabolism; D006460:Hemolysin Proteins; D008089:Listeria monocytogenes / Q000502:physiology*; D008264:Macrophages / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology*; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010740:Phospholipases / Q000145:classification / Q000378:metabolism; D011493:Protein Kinase C / Q000145:classification / Q000378:metabolism; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D001427:Bacterial Toxins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D016328:NF-kappa B; D011493:Protein Kinase C; D010740:Phospholipases; D010738:Type C Phospholipases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; C038705:hlyA protein, Listeria monocytogenes