Steroid hormones, endometrial gene regulation and the Sp1 family of proteins.
Endometrial gene expression can be regulated exquisitely by cyclical changes in ovarian steroid concentration. Although hormonal induction of many of these genes occurs through classical steroid response elements, other endometrial genes respond to steroids at the transcriptional level but do not contain steroid response elements. A family of transcription factors, namely the Sp1 family, has now been implicated as important mediators of steroid hormone action in the endometrium during the periimplantation and postimplantation periods. This review summarizes the current literature regarding the role of the Sp1 protein family in regulating the response to steroid hormones of genes for tissue factor, plasminogen activator inhibitor-1, insulin-like growth factor binding protein-1, uteroglobin, and uteroferrin in the endometrium.
Krikun
Graciela
G
Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA. graciela.krikun@yale.edu
Lockwood
Charles J
CJ
D000135:Acid Phosphatase; D000818:Animals; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000235:genetics; D007527:Isoenzymes; D008667:Metalloproteins / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D016329:Sp1 Transcription Factor; D013256:Steroids / Q000494:pharmacology*; D000071681:Tartrate-Resistant Acid Phosphatase; D013925:Thromboplastin / Q000235:genetics; D014598:Uteroglobin / Q000235:genetics
D018970:Insulin-Like Growth Factor Binding Protein 1; D007527:Isoenzymes; D008667:Metalloproteins; D017395:Plasminogen Activator Inhibitor 1; D016329:Sp1 Transcription Factor; D013256:Steroids; D013925:Thromboplastin; D014598:Uteroglobin; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase