Membrane rafts in immunoreceptor signaling: new doubts, new proofs?
Immunoreceptors are believed to initiate their signaling by association with membrane rafts rich in src-family kinases and other signaling molecules. Although a recent paper casts doubt over this concept, by exposing drawbacks of a commonly used procedure to disturb rafts by cholesterol extraction, several other recent papers give further support to the concept.
Horejsí
Václav
V
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Praha 4, Czech Republic. horejsi@biomed.cas.cz
D000818:Animals; D066298:In Vitro Techniques; D021962:Membrane Microdomains / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction
D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic