[Microcirculation in gastric mucosa as related to its secretory activity in patients with peptic ulcer].
A study was made into the condition of the capillary bed in 18 patients with peptic ulcer before and under exposure to lansoprazole treatments. Biopsy specimens were taken from the lesser curvature of the stomach: in the area of the upper third (intact zone) and lower third from the ulcer periphocal zone. It is the regional redistribution of blood in the gastric mucosa rather than amount of hydrochloric acid and pepsins in the gastric contents that has the most important part in pathogenetic mechanisms of ulcer formation in the stomach.
Shcherbynina
M B
MB
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy / Q000503:physiopathology*
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D064747:Lansoprazole; D009853:Omeprazole