Hox proteins: sculpting body parts by activating localized cell death.
Hox proteins shape animal structures by eliciting different developmental programs along the anteroposterior body axis. A recent study reveals that the Drosophila Hox protein Deformed directly activates the cell-death-promoting gene reaper to maintain the boundaries between distinct head segments.
Alonso
Claudio R
CR
Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK. cra21@hermes.cam.ac.uk
D000818:Animals; D017209:Apoptosis; D016923:Cell Death / Q000502:physiology; D004330:Drosophila / Q000033:anatomy & histology* / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D007301:Insect Hormones / Q000235:genetics / Q000502:physiology
C066676:Dfd protein, Drosophila; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones