title: [Role of adjuvant chemotherapy in the treatment of medulloblastoma in children].
abstract: A retrospective review was carried out to evaluate the results of treatment (1989-1998) of 81 children, aged under 15, with primary medulloblastoma. Thirty-three patients received surgery and postoperative craniospinal radiotherapy; 48--adjuvant chemotherapy (VCR 1.5 mg/m2, i.v., 1 day; CCNU 75 mg/m2, per os, 1 day; cisplatin 80 mg/m2 or carboplatin 400 mg/m2, i.v., 1 day). Overall 9-year survival was 37 +/- 0.8%. This index in the adjuvant chemotherapy group was 59 +/- 0.8%, without chemotherapy--22 +/- 0.8%.
authors.affiliation: N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
authors.forename: N V
authors.initials: NV
authors.lastname: Sachivko
authors.forename: N E
authors.initials: NE
authors.lastname: Konoplia
authors.forename: S V
authors.initials: SV
authors.lastname: Petrovich
authors.forename: E V
authors.initials: EV
authors.lastname: Sharak
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D002528:Cerebellar Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D011879:Radiotherapy Dosage; D012737:Sex Factors; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D008130:Lomustine; D016190:Carboplatin; D002945:Cisplatin