Antimycobacterial activity of lipodepsipeptides produced by Pseudomonas syringae pv syringae B359.
Some lipodepsipeptides produced by Pseudomonas syringae pv. syringae showed strong antimycobacterial activity towards Mycobacterium smegmatis. MIC values found were between 1.5-3.2 microg/ml, which is comparable to some primary drugs for tuberculosis. Among the lipodepsipeptides, Syringomycin E (SRE) appears to be the most potent antimycobacterial agent.
Buber
E
E
Department of Biochemistry, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey.
Stindl
A
A
Acan
N L
NL
Kocagoz
T
T
Zocher
R
R
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000187:drug effects; D005848:Geotrichum / Q000187:drug effects; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020102:Mycobacterium smegmatis / Q000187:drug effects; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011549:Pseudomonas / Q000737:chemistry / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000900:Anti-Bacterial Agents; D008074:Lipoproteins; D010456:Peptides, Cyclic; C402636:syringopeptin 22