Epidemiology of clinical isolates of Candida albicans and their susceptibility to triazoles.
The study comprised strains of Candida albicans isolated from patients hospitalised in a tertiary care hospital during a 2-year period. In total 851 strains were cultured, including 379 (44.5%) strains from internal medicine patients, 243 (28.6%) from surgical patients and 229 (26.9%) from patients in the surgical intensive care unit. The strains were tested for susceptibility to the triazoles: fluconazole and itraconazole. There were 523 (61.5%) strains susceptible, 11 strains (1.3%) showed intermediate susceptibility and 317 (37.2%) were resistant to fluconazole, while 403 (47.3%) strains were susceptible, 43 (5.1%) intermediately susceptible and 405 (47.6%) resistant to itraconazole. Regular surveillance of fungal resistance patterns should be carried out and there should be prudent use of hospital triazole usage.
Wroblewska
M M
MM
Department of Medical Microbiology, Medical University in Warsaw, 5 Chalubinskiego Street, 02-004 Warsaw, Poland. wroblewska@ib.amwaw.edu.pl
Swoboda-Kopec
E
E
Rokosz
A
A
Krawczyk
E
E
Marchel
H
H
Luczak
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D012189:Retrospective Studies
D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole