title: Tylosin depletion from edible pig tissues.
abstract: The depletion of tylosin from edible pig tissues was studied following 5 days of intramuscular (i.m.) administration of 10 mg/kg of tylosin to 16 crossbreed pigs. Animals were slaughtered at intervals after treatment and samples of muscle, kidney, liver, skin+fat, and injection site were collected and analysed by high-performance liquid chromatography (HPLC). Seven days after the completion of treatment, the concentration of tylosin in kidney, skin+fat, and at the injection site was higher than the European Union maximal residue limit (MRL) of 100 microg/kg. Tylosin residues in all tissues were below the quantification limit (50 microg/kg) at 10 and 14 days post-treatment.
authors.affiliation: Departament de Farmacologia i Terapèutica, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain. carme.prats@uab.es
authors.forename: C
authors.initials: C
authors.lastname: Prats
authors.forename: G
authors.initials: G
authors.lastname: El Korchi
authors.forename: R
authors.initials: R
authors.lastname: Francesch
authors.forename: M
authors.initials: M
authors.lastname: Arboix
authors.forename: B
authors.initials: B
authors.lastname: Pérez
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004350:Drug Residues / Q000493:pharmacokinetics*; D005506:Food Contamination / Q000517:prevention & control*; D007273:Injections, Intramuscular / Q000662:veterinary; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D008460:Meat / Q000032:analysis*; D018482:Muscle, Skeletal / Q000737:chemistry; D012867:Skin / Q000737:chemistry; D013552:Swine / Q000378:metabolism*; D013997:Time Factors; D015645:Tylosin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D015645:Tylosin