Cerebral regional hypometabolism caused by propofol-induced sedation in children with severe myoclonic epilepsy: a study using fluorodeoxyglucose positron emission tomography and statistical parametric mapping.
Cerebral positron emission tomography (PET) in children often requires sedation. This study evaluated sedation-associated effects on cerebral glucose metabolism in 30 children with severe myoclonic epilepsy as investigated by cerebral (18)F-fluorodeoxyglucose (FDG)-PET. Prior to the PET acquisition, 24 children underwent propofol sedation. Pixel-based t-statistics were calculated using statistical parametric mapping (SPM99) for comparisons of the patients' PET scans with both a healthy adult control group and an age-matched child intra-group control. In both analyses, statistically significant hypometabolic areas were found in the medial parieto-occipital cortex bilaterally, including the lingual gyrus, cuneus, posterior cingulate and middle occipital gyrus in all sedated children. All these localizations correlated in a covariate analysis with the injected dose of propofol (P<0.01, corrected). The bilateral parieto-occipital hypometabolism is likely to be a sedation-specific effect and should be taken into account when evaluating cerebral FDG-PET scans in sedated children.
Juengling
Freimut D
FD
Department of Radiology, Division of Nuclear Medicine, University Hospital Freiburg, Hugstetterstr. 55, D-79106, Freiburg, Germany. freimut.juengling@insel.ch
Kassubek
Jan
J
Martens-Le Bouar
Heike
H
Reinhardt
Michael J
MJ
Krause
Thomas
T
Nitzsche
Egbert U
EU
Moser
Ernst
E
Korinthenberg
Rudolf
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D000927:Anticonvulsants / Q000494:pharmacology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004831:Epilepsies, Myoclonic / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D015742:Propofol / Q000494:pharmacology*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D014055:Tomography, Emission-Computed
D000927:Anticonvulsants; D019788:Fluorodeoxyglucose F18; D005947:Glucose; D015742:Propofol