title: The eye in systemic sepsis.
abstract: Metastatic or endogenous endophthalmitis (EE) is a serious consequence of systemic sepsis. It is defined as intraocular infection resulting from haematogenous spread of organisms in which the initial focus of infection is at a site distal to the eye. A red/sore eye in a patient with a known septic focus needs urgent attention as EE can be a major cause of visual loss. Early diagnosis and treatment are associated with better visual outcome. This article focuses on the two main causes of EE, namely bacterial and fungal infections, and also briefly mentions dissemination of cytomegalovirus to the eye in immunocompromised patients. Although conscious patients may notice an ocular problem, unconscious or very sick patients may not; vigilance by medical staff in looking for early signs of this is extremely important.
authors.affiliation: Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, London.
authors.forename: Aldrin
authors.initials: A
authors.lastname: Khan
authors.forename: Narciss
authors.initials: N
authors.lastname: Okhravi
authors.forename: Susan
authors.initials: S
authors.lastname: Lightman
mesh_terms: D002177:Candidiasis / Q000150:complications / Q000188:drug therapy; D017726:Cytomegalovirus Retinitis / Q000175:diagnosis / Q000188:drug therapy; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology; D006801:Humans; D016867:Immunocompromised Host; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology