title: Delayed distribution of active vasodilation and altered vascular conductance in aged skin.
abstract: Reflex vasodilation is attenuated in aged skin during hyperthermia. We used laser-Doppler imaging (LDI) to test the hypothesis that the magnitude of conductance and the spatial distribution of vasodilation are altered with aging. LDI of forearm skin was compared in 12 young (19- to 29-yr-old) and 12 older (64- to 75-yr-old) men during supine passive heating. Additionally, iontophoresis of bretylium tosylate was performed in a subset of subjects to explore the involvement of sympathetic vasoconstriction in limiting skin blood flow. Passive heating with water-perfused suits clamped mean skin temperature at 41.0 +/- 0.5 degrees C, causing a ramp increase in esophageal temperature (T(es)) to </=38.5 degrees C. LDI scans were performed at baseline and at every 0.2 degrees C increase in T(es). LDI at bretylium and control sites was identical, suggesting no influence of noradrenergic vasoconstriction. Forearm vascular conductance (venous occlusion plethysmography) was reduced in the older men (P </= 0.001) at every elevated T(es). Mean cutaneous vascular conductance (CVC) of the scanned area was reduced in the older men at 0.2 degrees C </= DeltaT(es) </= 0.8 degrees C. Early in heating (0.2 degrees C </= DeltaT(es) </= 0.6 degrees C), older men also responded with a reduced vasodilated area (P </= 0.05), implying a slower recruitment or filling of skin microvessels. The results indicate that the area of vasodilation and CVC within the vasodilated area are reduced in aged skin during early passive heating, but only CVC is reduced at DeltaT(es) = 0.8 degrees C.
authors.affiliation: Noll Physiological Research Center, Pennsylvania State University, University Park, Pennsylvania 16802-6900, USA. jmp141@psu.edu
authors.forename: Jane M
authors.initials: JM
authors.lastname: Pierzga
authors.forename: Adam
authors.initials: A
authors.lastname: Frymoyer
authors.forename: W Larry
authors.initials: WL
authors.lastname: Kenney
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D015308:Anaerobic Threshold / Q000502:physiology; D001949:Bretylium Compounds / Q000494:pharmacology; D005334:Fever / Q000503:physiopathology; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007478:Iontophoresis; D017078:Laser-Doppler Flowmetry; D008297:Male; D009994:Osmolar Concentration; D012039:Regional Blood Flow / Q000502:physiology; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation / Q000502:physiology*
chemical_list: D001949:Bretylium Compounds; C045166:bretylium