Hypolipidaemic activity of methanol extract of Aleurites moluccana.
The lipid-lowering action of the leaves of the Aleurites moluccana methanol extract was studied in Triton W-1339 and high-fat-diet fed rats. The serum lipids (total cholesterol, LDL- and HDL-cholesterol and triglycerides) and body weight were found to be lowered by A. moluccana (300 mg/kg, b.w.) in rats with Triton-induced hypercholesterolaemia and on a hyperlipaemic diet. The results suggest that the lipid lowering action of this natural product is mediated through inhibition of hepatic cholesterol biosynthesis and reduction of lipid absorption in the intestine.
Pedrosa
R C
RC
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina - UFSC, Florianópolis - SC, Brazil.
Meyre-Silva
C
C
Cechinel-Filho
V
V
Benassi
J C
JC
Oliveira
L F S
LF
Zancanaro
V
V
Dal Magro
J
J
Yunes
R A
RA
D031284:Aleurites; D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D011092:Polyethylene Glycols; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; C016811:tyloxapol