title: Continuous Intraoperative Intraperitoneal Hyperthermic Chemoperfusion (CIIPHCP) in the treatment of advanced stage and recurrent granulosa cell tumors. Report of two cases.
abstract: BACKGROUND
  Treatment of advanced stages and recurrent ovarian granulosa cell tumors, has not been established yet. The effectiveness of radiation therapy could not be proven. Systemic chemotherapy has shown promising results, but with severe side effects and high incidence of relapse.
  
  
  METHODS
  We report of one patient with advanced stage III C, and one patient with bulky recurrent ovarian granulosa cell tumors. Both patients were treated with a combination of surgical debulking, Continuous Intraoperative Intraperitoneal Hyperthermic Chemoperfusion (CIIPHCP) with Cisplatin and one of them with adjuvant systemic chemotherapy.
  
  
  CONCLUSIONS
  CIIPHCP appears to offer a promising procedure in addition to surgical debulking and systemic chemotherapy for treatment of advanced or recurrent ovarian granulosa cell tumors. The present report is the first concerning the question of adding Intraoperative Hyperthermic Chemoperfusion in the treatment of advanced or recurrent ovarian granulosa cell tumors.
authors.affiliation: First Department of Surgical Oncology, Theagenion Cancer Hospital, Thessaloniki, Greece. chatzkon@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Chatzigeorgiou
authors.forename: S
authors.initials: S
authors.lastname: Economou
authors.forename: G
authors.initials: G
authors.lastname: Zafiriou
authors.forename: G
authors.initials: G
authors.lastname: Minopoulos
authors.forename: K
authors.initials: K
authors.lastname: Manolas
authors.forename: N
authors.initials: N
authors.lastname: Chatzigeorgiou
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D006106:Granulosa Cell Tumor / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D006979:Hyperthermia, Induced; D007430:Intraoperative Care; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D010477:Perfusion; D012008:Recurrence; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin