title: MMP-9 correlates with electrophysiologic abnormalities in Guillain-Barré syndrome.
abstract: To investigate the role of MMP-9 in Guillain-Barré syndrome, the authors correlated electrophysiologic abnormalities and MMP-9 plasma levels in a series of 21 patients. MMP-9 plasma levels were higher in the demyelinating group than in the nondemyelinating group, and in patients with high CSF protein level. Increase of MMP-9 circulating levels correlated with the increase of F waves latencies, reduction of CMAP amplitude, and decrease of nerve conduction velocities. Circulating MMP-9 may contribute to the peripheral nerve dysfunction of demyelinating Guillain-Barré syndrome.
authors.affiliation: Réseau de Neuroimmunologie du Nerf Périphérique, Université de Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Sharshar
authors.forename: M-C
authors.initials: MC
authors.lastname: Durand
authors.forename: J-P
authors.initials: JP
authors.lastname: Lefaucheur
authors.forename: F
authors.initials: F
authors.lastname: Lofaso
authors.forename: J-C
authors.initials: JC
authors.lastname: Raphaël
authors.forename: R K
authors.initials: RK
authors.lastname: Gherardi
authors.forename: A
authors.initials: A
authors.lastname: Créange
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins / Q000378:metabolism; D004568:Electrodiagnosis; D004594:Electrophysiology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology
chemical_list: D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D020780:Matrix Metalloproteinase 9