title: Serum deprivation-induced upregulation of voltage-dependent sodium channels in adrenal chromaffin cells: selective involvement of extracellular signal-regulated kinase pathway.
abstract: In the present study, we investigated whether activation of the MAPK family could regulate the cell surface expression of Na channels in cultured bovine adrenal chromaffin cells. The results suggest that constitutively activated ERK (but not p38 or JNK), by various extracellular stimuli, down-modulates the density of cell surface Na channels, which was mediated via the destabilization of Na channel alpha-subunit mRNA.
authors.affiliation: Department of Pharmacology, Miyazaki Medical College, Miyazaki 889-1692, Japan. yanagita@post1.miyazaki-med.ac.jp
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanagita
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yokoo
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Saitoh
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Minami
authors.forename: Seiji
authors.initials: S
authors.lastname: Shiraishi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Uezono
authors.forename: Akihiko
authors.initials: A
authors.lastname: Wada
mesh_terms: D000818:Animals; D002417:Cattle; D019439:Chromaffin Cells / Q000378:metabolism*; D016895:Culture Media, Serum-Free / Q000494:pharmacology; D004789:Enzyme Activation; D015151:Immunoblotting; D048031:JNK Mitogen-Activated Protein Kinases; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism; D015222:Sodium Channels / Q000378:metabolism*; D013997:Time Factors; D015854:Up-Regulation; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D016895:Culture Media, Serum-Free; D012333:RNA, Messenger; D015222:Sodium Channels; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases