title: Bottle feeding in the bed or crib before sleep time and wheezing in early childhood.
abstract: OBJECTIVE
  Bottle feeding in the bed or crib before sleep time has been associated with an increased risk of wheezing in the first year of life. We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life.
  
  
  METHODS
  In a prospective cohort study of 448 children with parental history of atopy followed from birth, we examined the relation between the number of bimonthly parental reports of bottle feeding in the bed or crib before sleep time in the first year of life (range: 0-6 reports) and parental report of wheezing in the first 5 years of life. Additional outcome measures included recurrent wheezing (> or =2 episodes of wheezing in the previous year) and asthma (physician-diagnosed asthma and > or =1 episode of wheezing in the previous year) at the age of 5 years.
  
  
  RESULTS
  The risk of recurrent wheezing and asthma at 5 years of age increased significantly with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. The risk of wheezing between the ages of 1 and 5 years increased with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. As an example, a child whose parents reported bottle feeding in the bed or crib before sleep time on 3 occasions in the first year of life had 1.5 times higher risk of wheezing between the ages of 1 and 5 years than a child whose parents did not report bottle feeding in the bed or crib before sleep time in the first year of life (95% confidence interval for relative risk: 1.12-2.12).
  
  
  CONCLUSIONS
  Among children with parental history of atopy, bottle feeding in the bed or crib before sleep time in the first year of life is a risk factor for recurrent wheezing and asthma at 5 years of age and a risk factor for wheezing between the ages of 1 and 5 years.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. juan.celedon@channing.harvard.edu
authors.forename: Juan C
authors.initials: JC
authors.lastname: Celedón
authors.forename: Augusto A
authors.initials: AA
authors.lastname: Litonjua
authors.forename: Louise
authors.initials: L
authors.lastname: Ryan
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
authors.forename: Diane R
authors.initials: DR
authors.lastname: Gold
mesh_terms: D001942:Breast Feeding / Q000706:statistics & numerical data; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D015370:Infant Equipment; D007225:Infant Food / Q000009:adverse effects / Q000706:statistics & numerical data*; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D011159:Population Surveillance; D011446:Prospective Studies; D012008:Recurrence; D012135:Respiratory Sounds / Q000209:etiology*; D018570:Risk Assessment; D012890:Sleep; D013997:Time Factors
chemical_list: D007073:Immunoglobulin E