Linomide administration following bone marrow transplantation in mice.
The effect of linomide, an immunomodulatory drug, on natural killer (NK) cells and T cell-dependent immune responses following syngeneic or allogeneic bone marrow transplantation (BMT) was investigated in BALB/c mice inoculated with B-cell leukemia (BCL1). Linomide given in the drinking water had no impact on graft survival or graft versus leukemia (GVL) effects. Although linomide regulates anti-self reactivity in mice with experimental and spontaneous autoimmune disorders, the anti-tumor effects induced by allogeneic donor lymphocytes were not affected. This indicates that different mechanisms regulate anti-self and anti-leukemia effects. Alternatively, linomide might affect the homing of self-reactive lymphocytes to specific target organs in autoimmune disorders, although the homing process may not be relevant to the control of leukemia by alloreactive lymphocytes.
Weiss
Lola
L
Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, Israel.
Abdul-Hai
Ali
A
Shufaro
Yoel
Y
Reich
Shoshanna
S
Slavin
Shimon
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D020544:Graft vs Leukemia Effect / Q000187:drug effects; D006912:Hydroxyquinolines / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D015448:Leukemia, B-Cell / Q000517:prevention & control; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D000276:Adjuvants, Immunologic; D006912:Hydroxyquinolines; C045282:roquinimex