[The effect of diagnostic contrast media on the activity of lactate dehydrogenase in rat blood].
It is shows that the diagnostic Roentgen contrast media (RCM) in a dose of 2.0 g iodine/kg increase the activity of lactate dehydrogenase in rat blood, the effect decreasing in the following order: iodamide > bilignost > triombrast > peritrast > melitrast > omnipaque > hexabrix. At the same time, the RCM in a dose of 0.5 g iodine/kg (iodine concentration, 0.03-30 mg/ml) and gadolinium-containing magnetic-resonance contrast media (MRCM) in a dose of 0.1 mM/kg (gadolinium concentration, 0.2-1 mg/ml) inhibit the enzyme, the effect decreasing in the following order: bilignost = iodamide = triombrast = peritrast > hexabrix > omnipaque = melitrast = ultravist = magnevist = dipentast. The mechanism of action of the contrast media on the LDH activity was studied and it was found that changes in the enzyme activity is correlated with the toxicity (LD 50) of RCM. The groups of risk from the standpoint of side reactions to the intravenous RCM introduction are determined.
Napolov
Iu K
IuK
Department of Molecular Pharmacology and Radiobiology, State Medical University, ul. Ostrovityanova, 1, Moscow, 117437 Russia.
Shimanovskiĭ
N L
NL
D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D005260:Female; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D003287:Contrast Media; D007770:L-Lactate Dehydrogenase