Meroterpenes from Penicillium sp found in association with Melia azedarach.
A Penicillium sp was isolated from the root bark of Melia azedarach and cultivated over sterilized rice. After chromatographic procedures, two meroterpenes, named preaustinoid A and B, were obtained in addition to the known alkaloid verruculogen. Their structures were identified by extensive spectroscopic studies, and they exhibited moderate bacteriostatic effects on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus sp.
Geris dos Santos
Regina M
RM
Departamento de Química, Universidade Federal de São Carlos, CP 676, 13 565-905 SP, Brazil.
Rodrigues-Fo
Edson
E
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007211:Indoles / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D031586:Melia azedarach / Q000382:microbiology*; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry* / Q000302:isolation & purification; D024301:Plant Bark / Q000382:microbiology; D018517:Plant Roots / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007211:Indoles; D013729:Terpenes; C473688:preaustinoid A; C473687:preaustinoid B; C009658:verruculogen