A model of myocarditis.
Myocarditis was induced by synergic interactions of serotonin- and cholinergic nerve fibers during potentiation of vagal inhibition of cardiac activity by stimulation of the stellate ganglion. Thus modeled myocarditis was associated with increased content of serotonin and decreased concentrations of acetylcholine and catecholamines in the myocardial tissue. Blockade of 5HT3(S3) receptors in autonomic ganglia and 5HT1,2(S1,2) receptors in the myocardium improved myocardial contractility and reduced the severity of myocarditis.
Lychkova
A E
AE
Department of Physiology, Russian State Medical University, Moscow.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D009200:Myocardial Contraction / Q000187:drug effects; D009205:Myocarditis / Q000473:pathology / Q000503:physiopathology*; D009638:Norepinephrine / Q000378:metabolism; D011817:Rabbits; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology; D013233:Stellate Ganglion / Q000473:pathology; D014630:Vagus Nerve / Q000473:pathology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D000109:Acetylcholine; D009638:Norepinephrine