Inhibition by ajoene of skin-tumor promotion in mice.
Ajoene, a major compound containing sulfur in oil-macerated garlic products, inhibited in a two-stage carcinogenesis test on mouse skin. Treatment with ajoene suppressed skin tumor formation, depending on the amount. In particular, the group treated with 250 microg of ajoene had only 4.9% the number of tumors per mouse compared with the control group at 18 weeks.
Nishikawa
Tomoaki
T
Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd., 310 Nakasuna-cho, Tempaku-ku, Nagoya, Aichi 468-0065, Japan.
Yamada
Norihiko
N
Hattori
Atsuhiko
A
Fukuda
Hiroyuki
H
Fujino
Tsuchiyoshi
T
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002273:Carcinogens / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000633:toxicity; D004220:Disulfides / Q000494:pharmacology*; D005737:Garlic / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D012997:Solvents; D013454:Sulfoxides; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors / Q000633:toxicity
D000972:Antineoplastic Agents, Phytogenic; D002273:Carcinogens; D004220:Disulfides; D010936:Plant Extracts; D012997:Solvents; D013454:Sulfoxides; D015127:9,10-Dimethyl-1,2-benzanthracene; C048980:ajoene; D013755:Tetradecanoylphorbol Acetate