[Comparative study of clinical effectiveness of antibiotic prophylaxis in aseptic mouth-jaw- and facial surgery].
METHODS
This study evaluates the clinical efficiency of four regimens of antibiotic prophylaxis against wound infection in aseptic oral and maxillofacial surgery that does not involve implantation of foreign material and included 140 adult patients randomly distributed into four groups. Patients from two groups received prophylactic amoxicillin/clavulanate in a single-dose regimen or a 5-day regimen, respectively. Subjects from the other two groups received cefazolin in a single-dose regimen or a 5-day regimen, respectively.


RESULTS
Clinical prophylactic efficiency proved to be equal for the four types of antibiotic regimens.


CONCLUSIONS
Single-dose regimens are more economical, easier to administer, and carry a lower risk of inducing bacterial resistance. Amoxicillin/clavulanate is more expensive than cefazolin. For aseptic maxillofacial surgery that does not involve implantation of foreign material, we recommend preoperative single-dose antibiotic prophylaxis with cefazolin 2 g i.v. (in adult patients).
Cioacã
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Fakultät für Stomatologie und Universitätskrankenhaus Prof. Dr. D. Theodorescu, Cl. Plevnei 19, Bucuresti, Sector 1, RO-70 756, Rumania. ruxandra5@pcnet.ro
Bucur
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Coca-Nicolae
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Coca
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D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage* / Q000191:economics; D019072:Antibiotic Prophylaxis / Q000191:economics; D002437:Cefazolin / Q000008:administration & dosage* / Q000191:economics; D004334:Drug Administration Schedule; D016527:Drug Costs / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013515:Surgery, Oral; D013530:Surgical Wound Infection / Q000517:prevention & control*
D019980:Amoxicillin-Potassium Clavulanate Combination; D002437:Cefazolin