title: Autoimmune progesterone dermatitis.
abstract: Autoimmune progesterone dermatitis (APD) is an uncommon cutaneous disorder characterized by exacerbations during the luteal phase of the menstrual cycle. We describe a 27-year-old woman with a recurrent skin eruption for 3 years. She had no history of exposure to synthetic progesterones. At each menses, the patient developed scaly, erythematous maculopapular lesions over the face. Intradermal skin test reaction to progesterone was positive. Progesterone sensitivity was also demonstrated by challenge test with intramuscular progesterone acetate. These features were consistent with the diagnosis of APD. Our patient was treated successfully with conjugated estrogen for 6 months. At one year follow-up, the patient had had no recurrence of facial eruption.
authors.affiliation: Department of Dermatology, Bayindir Medical Centre Ankara, Mesa Park Sitesi, Sedir Apt. Daire: 44, 06450 Oran/Ankara/Turkey. tubaoskay@hotmail.com
authors.forename: Tuğba
authors.initials: T
authors.lastname: Oskay
authors.forename: Lale
authors.initials: L
authors.lastname: Kutluay
authors.forename: Asli
authors.initials: A
authors.lastname: Kaptanoğlu
authors.forename: Onur
authors.initials: O
authors.lastname: Karabacak
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000473:pathology*; D001707:Biopsy, Needle; D003872:Dermatitis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D004954:Esthetics; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008597:Menstrual Cycle / Q000276:immunology; D010507:Periodicity; D011374:Progesterone / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D004966:Estrogens, Conjugated (USP); D011374:Progesterone