title: Pathomorphological and immunohistochemical analysis biopsy specimens from large bronchi of patients with pulmonary cancer.
abstract: Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predominance of atrophic and sclerotic changes, lymph flow disorders, and tendency to lymphoid aggregation. These data suggest that not only dysplasia, but also the combination of all structural changes typical of each form of pulmonary cancer should be considered as a morphological marker of enhanced risk of tumor development.
authors.affiliation: Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: G I
authors.initials: GI
authors.lastname: Nepomnyashchikh
authors.forename: V A
authors.initials: VA
authors.lastname: Levitskii
authors.forename: A K
authors.initials: AK
authors.lastname: Dolgovykh
authors.forename: L A
authors.initials: LA
authors.lastname: Naumova
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001980:Bronchi / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged