Stationary phase in yeast.
Eukaryotic cell proliferation is controlled by specific growth factors and the availability of essential nutrients. If either of these signals is lacking, cells may enter into a specialized nondividing resting state, known as stationary phase or G(0). The entry into such resting states is typically accompanied by a dramatic decrease in the overall growth rate and an increased resistance to a variety of environmental stresses. Since most cells spend most of their life in these quiescent states, it is important that we develop a full understanding of the biology of the stationary phase/G(0) cell. This knowledge would provide important insights into the control of two of the most fundamental aspects of eukaryotic cell biology: cell proliferation and long-term cell survival. This review will discuss some recent advances in our understanding of the stationary phase of growth in the budding yeast, Saccharomyces cerevisiae.
Herman
Paul K
PK
Department of Molecular Genetics, The Ohio State University, 484 West Twelfth Avenue, Room 984, Columbus, Ohio 43210, USA. herman.81@osu.edu
D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal / Q000502:physiology; D008954:Models, Biological; D016192:Resting Phase, Cell Cycle / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology