Polymerized rosin: novel film forming polymer for drug delivery.
Polymerized rosin (PR) a novel film forming polymer is characterized and investigated in the present study for its application in drug delivery. Films were produced by a casting/solvent evaporation method from plasticizer free and plasticizer containing solutions. Films prepared from different formulations were studied for their mechanical (tensile strength, percent elongation and Young's modulus), water vapour transmission and moisture absorption characteristics. Neat PR films were slightly brittle and posed the problem of breaking during handling. Hydrophobic plasticizers, dibutyl sebacate and tributyl citrate, improved the mechanical properties of free films with both the plasticizers showing significant effects on film elongation. Release of diclofenac sodium (model drug) from coated pellets was sustained with high coating levels. Concentration of plasticizer was found to affect the release profile. PR films plasticized with hydrophobic plasticizers could therefore be used in coating processes for the design of oral sustained delivery dosage forms.
Fulzele
S V
SV
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur 440010, India. fsuniket@yahoo.com
Satturwar
P M
PM
Dorle
A K
AK
D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems / Q000379:methods*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D012116:Resins, Plant / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics
D011108:Polymers; D012116:Resins, Plant; C013893:rosin