title: The impact of duration of untreated psychosis and premorbid functioning on outcome of first inpatient treatment in schizophrenic and schizoaffective patients.
abstract: OBJECTIVE
  The aim of the study was to investigate the association between the duration of untreated psychosis, premorbid functioning and outcome from first inpatient treatment in schizophrenic or schizoaffective patients.
  
  
  METHODS
  The data of 196 first-hospitalized patients with a schizophrenic or schizoaffective disorder according to the ICD-10 criteria were analyzed using univariate and multivariate methods. Patients' characteristics were prospectively assessed using standardized instruments at the time of first admission and discharge.
  
  
  RESULTS
  The analyses revealed that a duration of untreated psychosis longer than 12 months was independently and significantly associated with a poorer outcome from first inpatient treatment. Premorbid functioning might have an additional influence on outcome, but this influence seems to be dependent on the diagnostic category.
  
  
  CONCLUSIONS
  The findings suggest that the duration of untreated psychosis is an independent prognostic factor for the outcome in schizophrenic and schizoaffective disorders.
authors.affiliation: Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany. bottlend@psy.med.uni-muenchen.de
authors.forename: Ronald
authors.initials: R
authors.lastname: Bottlender
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sato
authors.forename: Markus
authors.initials: M
authors.lastname: Jäger
authors.forename: Constanze
authors.initials: C
authors.lastname: Groll
authors.forename: Anton
authors.initials: A
authors.lastname: Strauss
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006760:Hospitalization; D006801:Humans; D038801:International Classification of Diseases; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology* / Q000534:rehabilitation*; D012559:Schizophrenia / Q000175:diagnosis / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D013997:Time Factors