title: Cardiac autonomic nervous dysfunction in diabetic patients with a mitochondrial DNA mutation: assessment by heart rate variability.
abstract: OBJECTIVE
  To elucidate the degree and characteristics of cardiac autonomic nervous dysfunction in diabetic patients associated with a mitochondrial DNA mutation at base pair 3243.
  
  
  METHODS
  We investigated heart rate variability using 24-h Holter monitoring in 10 diabetic patients with the mutation compared with 55 ordinary diabetic patients and 45 nondiabetic control subjects.
  
  
  RESULTS
  Age and sex were similar in the three groups. Between patients with the mutation and ordinary diabetic patients, the duration of diabetes and blood glycemic levels were not different. In the time domain analysis of heart rate variability, patients with the mutation and ordinary diabetic patients had significantly smaller SDNN index and pNN50 than control subjects. Compared with ordinary diabetic patients, patients with the mutation had smaller SDNN index (P < 0.02), but rMSSD and pNN50 were not different. In the frequency domain analysis, total, low frequency (LF), and high frequency (HF) spectra were significantly smaller in patients with the mutation and ordinary diabetic patients than in control subjects. Compared with ordinary diabetic patients, patients with the mutation had smaller total and LF spectra (P < 0.02). However, HF spectra were not significantly different. Notably, the LF/HF spectra ratio was lower in patients with the mutation than in ordinary diabetic patients and control subjects (P < 0.05), but this ratio was similar in ordinary diabetic patients and control subjects.
  
  
  CONCLUSIONS
  Our results suggest that diabetic patients with the mitochondrial DNA mutation have more severely impaired cardiac autonomic nervous function with sympathovagal imbalance, as compared with ordinary diabetic patients.
authors.affiliation: First Department of Internal Medicine, National Defense Medical College, Saitama, Japan. momiyama@me.ndmc.ac.jp
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Momiyama
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Masako
authors.initials: M
authors.lastname: Ohtomo
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Atsumi
authors.forename: Kempei
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ohsuzu
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kimura
mesh_terms: D017668:Age of Onset; D000704:Analysis of Variance; D001794:Blood Pressure; D002940:Circadian Rhythm / Q000502:physiology*; D004272:DNA, Mitochondrial / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000235:genetics* / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory; D005260:Female; D006329:Heart Conduction System; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012016:Reference Values
chemical_list: D004272:DNA, Mitochondrial