Helicity induction in a bichromophore: a sensitive and practical chiroptical method for absolute configuration determination of aliphatic alcohols.
[reaction: see text] A practical method for the determination of the absolute configuration of aliphatic secondary alcohols, based on the circular dichroism of the readily available N-(1,8-naphthaloyl)-2-aminobenzoyl (NAB) derivative, is presented. The origin of the induced Cotton effects is traced by ab initio calculations to the dominant helicity of the NAB pi-electron system.
Gawroński
Jacek
J
Department of Chemistry, A. Mickiewicz University, Poznan 60 780, Poland. gawronsk@amu.edu.pl
Kwit
Marcin
M
Gawrońska
Krystyna
K