title: Phytochemical constituents of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines.
abstract: Five terpenes (1-5), three fatty acids (6-8), two sterols (9 and 11), and a monogalactosyldiacyl glycerol (10) were isolated from the methylene chloride extract of the aerial part of Cirsium setidens. Their chemical structures were determined to be alpha-tocopherol (1), 25-hydroperoxycycloart-23-en-3beta-ol (2), 24-hydroperoxycycloart-25-en-3beta-ol (3), mokko lactone (4), transphytol (5), 9,12,15-octadecatrienoic acid (6), 9,12-octadecadienoic acid (7), hexadecanoic acid (8), acylglycosyl beta-sitosterol (9), (2R)-1,2-O-(9z,12z,15z-dioctadecatrienoyl)-3-O-beta-D-galactopyranosyl glycerol (10) and beta-sitosterol glucoside (11) by spectral evidences. Compound 3 exhibited significant cytotoxic activity against five human cancer cell lines with its ED50 values ranging from 2.66 to 11.25 microM.
authors.forename: Won Bin
authors.initials: WB
authors.lastname: Lee
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
authors.forename: Ock Ryun
authors.initials: OR
authors.lastname: Cho
authors.forename: Kang Choon
authors.initials: KC
authors.lastname: Lee
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Nam In
authors.initials: NI
authors.lastname: Baek
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D031180:Cirsium / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D035261:Plant Components, Aerial / Q000737:chemistry / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D014407:Tumor Cells, Cultured
chemical_list: D010936:Plant Extracts