title: [Spontaneous and induced variability of Streptomyces aureofaciens--chlortetracycline producer].
abstract: Spontaneous and induced variability of Streptomyces aureofaciens strain T[symbol: see text] 633 [symbol: see text] and its variants has been investigated. Correlative relation between the antibiotic formation and colonies morphology was observed. Combined effect of nitrosoguanidine and UV-beams resulted in the obtaining of 27 variants which exceeded activity of strain T[symbol: see text] 633 [symbol: see text] by 30-35% and were stable as to antibiotic biosynthesis during 7-10 generations.
authors.affiliation: Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.
authors.forename: H M
authors.initials: HM
authors.lastname: Stryzhkova
authors.forename: O P
authors.initials: OP
authors.lastname: Kopeĭko
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Lavrinchuk
authors.forename: O I
authors.initials: OI
authors.lastname: Bambura
authors.forename: B P
authors.initials: BP
authors.lastname: Matseliukh
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002751:Chlortetracycline / Q000096:biosynthesis*; D014644:Genetic Variation; D009154:Mutation; D009604:Nitrosoguanidines / Q000494:pharmacology; D013304:Streptomyces aureofaciens / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D009604:Nitrosoguanidines; D002751:Chlortetracycline