Aging in bacteria.
Analysis of senescent Escherichia coli cells reveals a link between protein oxidation and the fidelity of the translational apparatus. This model system has also provided a mechanistic molecular explanation for a trade-off between reproduction and survival activities, which may inspire proponents of the disposable soma theory and antagonistic pleiotropy hypothesis of aging.
Nyström
Thomas
T
Department of Cell and Molecular Biology - Microbiology, Göteborg University Medicinaregatan 9C, Göteborg, Sweden. Thomas.nystrom@gmm.gu.se
D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D010084:Oxidation-Reduction; D014176:Protein Biosynthesis / Q000502:physiology*; D012641:Selection, Genetic; D012808:Sigma Factor / Q000378:metabolism; D013997:Time Factors
D001426:Bacterial Proteins; D012808:Sigma Factor