[Study of CD44v6 protein expression in intraductal papilloma and its malignant transformation of breast].
OBJECTIVE
CD44v6 plays an important role in the malignant transformation of breast epithelia and is differentially expressed in normal and neoplastic breast tissue. The diagnostic value of this marker in differentiating malignant from benign breast lesions has not been well examined. This study was designed to evaluate the diagnostic value of CD44v6 protein in distinguishing between benign and malignant papillary lesions of the breast, which is be difficult morphologically, by determining the level of CD44v6 expression in different lesions of the breast.


METHODS
The level of CD44v6 protein was detected by immunohistochemistry in 111 paraffin-embeded blocks.


RESULTS
The positive expressive rates of CD44v6 protein in the basal epithelial cells of the normal tissue, intraductal papilloma, and its malignant transformation, intraductal carcinoma, invasive ductal carcinoma were 95.00%, 85.72%, 66.66%, 66.66%, and 0.00% respectively. The difference between the intraductal papilloma and its malignant transformation was not significant(P > 0.05). However, the positive expressive rates of CD44v6 protein in the luminal epithelial cells of the above lesions were 5.00%, 20.41%, 83.34%, 93.33%, and 100% respectively. There was difference between intraductal papilloma and its malignant transformation(P < 0.01).


CONCLUSIONS
CD44v6 detection by immunohistochemistry is useful in distinguishing intraductal papilloma from its malignant transformation of the breast.
He
Jie-Hua
JH
Department of Pathology, Cancer Hospital, Sun Yat-sen University, Guangzhou 510060, P. R. China.
Liang
Xiao-man
XM
Hou
Jing-hui
JH
Huan
Yi-li
YL
Wu
Qiu-liang
QL
Xiao
Yong-bo
YB
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D018300:Papilloma, Intraductal / Q000378:metabolism* / Q000473:pathology
C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors