title: New subtraction algorithms for evaluation of lesions on dynamic contrast-enhanced MR mammography.
abstract: We report new subtraction algorithms for the detection of lesions in dynamic contrast-enhanced MR mammography(CE MRM). Twenty-five patients with suspicious breast lesions underwent dynamic CE MRM using 3D fast low-angle shot. After the acquisition of the T1-weighted scout images, dynamic images were acquired six times after the bolus injection of contrast media. Serial subtractions, step-by-step subtractions, and reverse subtractions, were performed. Two radiologists attempted to differentiate benign from malignant lesion in consensus. The sensitivity, specificity, and accuracy of the method leading to the differentiation of malignant tumor from benign lesions were 85.7, 100, and 96%, respectively. Subtraction images allowed for better visualization of the enhancement as well as its temporal pattern than visual inspection of dynamic images alone. Our findings suggest that the new subtraction algorithm is adequate for screening malignant breast lesions and can potentially replace the time-intensity profile analysis on user-selected regions of interest.
authors.affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul. cbg@catholic.ac.kr
authors.forename: Byung Gil
authors.initials: BG
authors.lastname: Choi
authors.forename: Hak Hee
authors.initials: HH
authors.lastname: Kim
authors.forename: Euy Neyng
authors.initials: EN
authors.lastname: Kim
authors.forename: Bum-soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Han
authors.forename: Seung-Schik
authors.initials: SS
authors.lastname: Yoo
authors.forename: Seog Hee
authors.initials: SH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D016477:Artifacts; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011446:Prospective Studies; D011856:Radiographic Image Enhancement; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D013997:Time Factors; D016387:Women's Health