Andirol A and B, two unique 6-hydroxymethylpterocarpenes from Andira inermis.
From a methanolic extract of the leaves of Andira inermis (Fabaceae), andirol A and B, two compounds with a novel type of a rotenoid-related skeleton and andinermol, a new 2-aryl-3-hydroxymethyl-benzofuran could be isolated. Characterisation and structure elucidation of these compounds was achieved on the basis of their spectral data. In addition, the in vitro activities of the isolated compounds against both the chloroquine-sensitive strain PoW and the chloroquine-resistant clone Dd2 of Plasmodium falciparum have been evaluated.
Kraft
Carola
C
Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Gremany.
Jenett-Siems
Kristina
K
Köhler
Inga
I
Siems
Karsten
K
Abbiw
Daniel
D
Bienzle
Ulrich
U
Eich
Eckart
E
D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification; D007887:Fabaceae / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D008958:Models, Molecular; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification
D000447:Aldehydes; D001572:Benzofurans; D006576:Heterocyclic Compounds, 4 or More Rings; D010936:Plant Extracts; C448099:andinermal; C469686:andirol A; C469687:andirol B; D000432:Methanol