Chemokine receptor expression on T cells is related to new lesion development in multiple sclerosis.
The expression of chemokine receptors CCR5 and CXCR3 on CD4 and CD8 positive T cells in blood, measured by flow cytometry, was studied in 124 patients with different clinical subtypes of multiple sclerosis (MS) and 22 healthy controls. In a subgroup of patients (n=69) from whom MRI was available, chemokine receptor expression was correlated to the annualised changes in T1 and T2 lesion load. It was found that CCR5 and CXCR3 on both cell types might have impact on annualised increase in T2 lesion load, but not on T1 lesion load. Our results suggest that chemokines may play a more important role in the development of new lesions in MS than in the long-term outcome of those lesions.
Eikelenboom
M J
MJ
Department of Neurology, VU Medical Centre, De Boelelaan 1117, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. j.eikelenboom@vumc.nl
Killestein
J
J
Izeboud
T
T
Kalkers
N F
NF
van Lier
R A W
RA
Barkhof
F
F
Uitdehaag
B M J
BM
Polman
C H
CH
D000328:Adult; D000367:Age Factors; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology* / Q000473:pathology; D011237:Predictive Value of Tests; D019713:Receptors, CCR5 / Q000276:immunology; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
C515187:CXCR3 protein, human; D019713:Receptors, CCR5; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine