Acid-promoted DNA-cleaving activities and total synthesis of varacin C.
The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.
Lee
Alex H F
AH
Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Chen
Jian
J
Liu
Dongsheng
D
Leung
Thomas Y C
TY
Chan
Albert S C
AS
Li
Tianhu
T
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology; D004249:DNA Damage; D004270:DNA, Circular / Q000187:drug effects* / Q000378:metabolism; D004278:DNA, Superhelical / Q000187:drug effects* / Q000378:metabolism; D004347:Drug Interactions; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013440:Sulfides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004270:DNA, Circular; D004278:DNA, Superhelical; D005021:Ethylamines; D013438:Sulfhydryl Compounds; D013440:Sulfides; C093887:varacin C