Mortality study of workers compensated for asbestosis in Poland, 1970-1997.
The aim of the study was to assess the risk of asbestos-related malignancies among persons with diagnosed asbestosis. The study covered a cohort composed of 907 men and 490 women afflicted by asbestosis, diagnosed is 1970-1997. The follow-up of the cohort continued until 31 December 1999. In all, 421 deaths were registered and causes of death were retrieved for 93.3% of the deceased. A significantly increased mortality was observed both in the male 1300 deaths; SMR = 127; 95%CI: 113-142) and female (121 deaths, SMR = 150; 95%CI: 124-179) cohorts. The elevated number of deaths in the male and female cohorts were noted mainly due to respiratory diseases (men: 42 deaths; SMR = 344; 95%CI: 248-465; women: 20 deaths, SMR = 789; 95%CI: 482-1219) malignant neoplasms (men: 91 deaths, SMR = 146; 95%CI: 118-179; women: 34 deaths, SMR = 159; 95%CI: 110-222), including lung cancer (men: 39 deaths, SMR = 168; 95% CI: 119-230; women: 13 deaths, SMR = 621; 95%CI: 331-1062) and pleural mesothelioma (men: 3 deaths, SMR = 2680; 95%CI: 553-7832; women: 3 deaths, SMR = 7207; 95%CI: 1031-14612). Taking into account a cumulative dose of fibers, it was found that a significantly increased mortality from lung cancer and pleural mesothelioma applied to persons exposed to a dose above 25 f-y/ml. The results indicate that persons with asbestosis are at higher risk of developing malignant neoplasms, especially lung cancer and mesothelioma.
Szeszenia-Dabrowska
Neonila
N
Department of Occupational and Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lódź, Poland. wies@imp.lodz.pl
Urszula
Wilczyńska
W
Szymczak
Wesław
W
Strzelecka
Alicja
A
D000328:Adult; D000368:Aged; D001195:Asbestosis / Q000150:complications / Q000401:mortality*; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000401:mortality*; D008297:Male; D008654:Mesothelioma / Q000150:complications / Q000401:mortality*; D008875:Middle Aged; D009784:Occupational Diseases / Q000150:complications / Q000401:mortality*; D010997:Pleural Neoplasms / Q000150:complications / Q000401:mortality*; D011044:Poland / Q000453:epidemiology; D018570:Risk Assessment; D014942:Workers' Compensation