[Tinea capitis. Therapeutic options in the post-griseofulvin era].
Tinea capitis is the most common dermatophyte infection during childhood. In Germany, only griseofulvin is approved for therapy by regulatory agencies. In recent years, several newer antifungal agents such as itraconazole, fluconazole and terbinafine have broadened the therapeutic armamentarium and are used for the treatment of childhood tinea capitis. Itraconazole and terbinafine seem to be equally or more effective in treatment of tinea capitis within a shorter period of time than griseofulvin. Fluconazole is probably also effective for this indication, although supporting data is limited. Encountered side effects as well as interactions with other drugs appear to be well within acceptable limits for all three drugs. In conclusion, systemic therapy of scalp ringworm with itraconazole and terbinafine, as well as perhaps fluconazole, seems to be an equivalent or a superior therapeutic approach as compared to the use of griseofulvin. For the future, regulatory approval for the use of these newer antifungal agents in tinea capitis of childhood is recommended.
Möhrenschlager
M
M
Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Germany. m.moehrenschlager@lrz.tum.de
Korting
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HC
Seidl
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Ring
J
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Abeck
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D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D015725:Fluconazole / Q000009:adverse effects / Q000627:therapeutic use; D006118:Griseofulvin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects / Q000627:therapeutic use; D009281:Naphthalenes / Q000009:adverse effects / Q000627:therapeutic use; D000077291:Terbinafine; D014006:Tinea Capitis / Q000188:drug therapy*; D016896:Treatment Outcome
D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D006118:Griseofulvin; D015725:Fluconazole; D000077291:Terbinafine