Apoptotic pathways: involvement of lysosomal proteases.
Apoptosis or programmed cell death is the major mechanism used by multicellular organisms to remove infected, excessive and potentially dangerous cells. Cysteine proteases from the caspase family play a crucial role in the process. However, there is increasing evidence that lysosomal proteases are also involved in apoptosis. In this review various lysosomal proteases and their potential contribution to propagation of apoptosis are discussed.
Turk
Boris
B
Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia.
Stoka
Veronica
V
Rozman-Pungercar
Jerica
J
Cirman
Tina
T
Droga-Mazovec
Gabriela
G
Oresić
Kristina
K
Turk
Vito
V
D000818:Animals; D017209:Apoptosis; D010450:Endopeptidases / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; C018589:lysosomal proteins; D010450:Endopeptidases