title: Relationship between CAG repeat length and late-stage outcomes in Huntington's disease.
abstract: The relationship between CAG repeat length and age at nursing home (NH) admission and age at percutaneous endoscopic gastrostomy (PEG) was examined in 47 residents of a specialized Huntington's disease long-term care facility who were observed for a median of 3 years (range, 1 to 11 years). CAG repeat length was inversely correlated with time to NH admission and PEG (both p < 0.001), independent of age at onset. CAG repeat length may influence disease progression to late-stage outcomes in addition to age at onset.
authors.affiliation: Department of Neurology, Sergievsky Center, and The Taub Institute, Columbia University, New York, NY 10032, USA. ksm1@columbia.edu
authors.forename: K
authors.initials: K
authors.lastname: Marder
authors.forename: S
authors.initials: S
authors.lastname: Sandler
authors.forename: A
authors.initials: A
authors.lastname: Lechich
authors.forename: J
authors.initials: J
authors.lastname: Klager
authors.forename: S M
authors.initials: SM
authors.lastname: Albert
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D004724:Endoscopy; D005260:Female; D005774:Gastrostomy; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes; D012044:Regression Analysis; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D016019:Survival Analysis; D015431:Weight Loss / Q000502:physiology