Does a preexisting anxiety disorder predict response to paroxetine in irritable bowel syndrome?
Irritable bowel syndrome (IBS) is the most common disorder in patients seen by gastroenterologists. Twenty subjects with IBS diagnosed with the Rome criteria were treated for 12 weeks with 20-40 mg/day of paroxetine (mean dose=31 mg/day). At baseline, 10 patients had a lifetime history of an anxiety disorder, and 10 patients did not have such a history. Both groups had similar improvement in abdominal pain, constipation, diarrhea, incomplete emptying, and bloating/ abdominal distension. Paroxetine was very well tolerated.
Masand
Prakash S
PS
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. masan001@mc.duke.edu
Gupta
Sanjay
S
Schwartz
Thomas L
TL
Kaplan
David
D
Virk
Subhdeep
S
Hameed
Ahmad
A
Lockwood
Kari
K
D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D003109:Colonic Diseases, Functional / Q000188:drug therapy* / Q000523:psychology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012650:Self Disclosure; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index
D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors