Impact of genotyping of Mycobacterium tuberculosis on public health practice in Massachusetts.
Massachusetts was one of seven sentinel surveillance sites in the National Tuberculosis Genotyping and Surveillance Network. From 1996 through 2000, isolates from new patients with tuberculosis (TB) underwent genotyping. We describe the impact that genotyping had on public health practice in Massachusetts and some limitations of the technique. Through genotyping, we explored the dynamics of TB outbreaks, investigated laboratory cross-contamination, and identified Mycobacterium tuberculosis strains, transmission sites, and accurate epidemiologic links. Genotyping should be used with epidemiologic follow-up to identify how resources can best be allocated to investigate genotypic findings.
Miller
Ann C
AC
Massachusetts Department of Public Health, Jamaica Plain, Massachusetts 02130, USA.
Sharnprapai
Sharon
S
Suruki
Robert
R
Corkren
Edward
E
Nardell
Edward A
EA
Driscoll
Jeffrey R
JR
McGarry
Michael
M
Taber
Harry
H
Etkind
Sue
S
D015373:Bacterial Typing Techniques / Q000379:methods / Q000706:statistics & numerical data*; D016000:Cluster Analysis; D016358:Contact Tracing; D003951:Diagnostic Errors; D004196:Disease Outbreaks; D004866:Equipment Contamination; D005838:Genotype; D006703:Ill-Housed Persons; D006801:Humans; D007753:Laboratories / Q000592:standards; D008404:Massachusetts / Q000453:epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D015980:Public Health Practice / Q000592:standards; D018571:Sentinel Surveillance; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology* / Q000635:transmission