[Hyperlipidemia--side-effect of the treatment with an atypical antipsychotic (zotepine)?].
In the last few years some studies and case reports has been published that suggest a frequent occurrence of metabolic disorders like hyperglycemia and hyperlipidemia during the treatment with atypical antipsychotics. However, regarding the high prevalence rates of these disorders in the general population, a possible causative relationship should be substantiated, i.e. occurrence of elevated blood levels within a short time interval after the starting of the medication. In the presented case a hyperlipidemia (triglycerides up to 1247 mg/dl) was observed soon after the beginning of zotepine medication. After the reduction of zotepine lipid levels in serum decreased and normalised after switching to classical antipsychotics. Therefore a causative relationship between the occurrence of the hyperlipidemia and the zotepine medication is very likely.
Wetterling
Tilman
T
Klinik für Psychiatrie und Psychotherapie I, Johann-Wolfgang-Goethe-Universität, Frankfurt/Main, Germany.
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003988:Dibenzothiepins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced*; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced; D008055:Lipids / Q000097:blood; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D008055:Lipids; D014280:Triglycerides; C022172:zotepine