Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation.
Proton magnetic resonance spectroscopy (MRS) revealed a distinct resonance at 3.15 ppm in the brain of a 5-year-old male diagnosed with autism. The resonance assignment is attributable to ingestion of methylsulfonylmethane (MSM) as a dietary supplement. Glucosamine with MSM is marketed as a source of dietary sulfur and treatment of joint pain. Recognition of this chemical on brain proton MRS as an exogenous compound is necessary to avoid confusion as a pathologic metabolite of pediatric metabolic disease.
Cecil
Kim M
KM
Department of Radiology/MC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. cecil@athena.chmcc.org
Lin
Alexander
A
Ross
Brian D
BD
Egelhoff
John C
JC
D001321:Autistic Disorder / Q000378:metabolism*; D002675:Child, Preschool; D019587:Dietary Supplements; D004121:Dimethyl Sulfoxide; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013450:Sulfones / Q000378:metabolism*
D013450:Sulfones; C025910:dimethyl sulfone; D004121:Dimethyl Sulfoxide