title: An early cancer of the gastric cardia arising from carditis after long-term gastroesophageal reflux disease in the absence of Helicobacter pylori infection.
abstract: We describe an early gastric cardiac cancer in a patient who had suffered long-term gastroesophageal reflux disease (GERD) but showed no evidence of infection with Helicobacter pylori. Proximal gastrectomy and partial resection of the lower esophagus was performed. Histological examination revealed the lesion to be a gastric cardiac adenocarcinoma, which had partially invaded the submucosal layer. Intestinal metaplasia was also found in some areas. Inflammation, however, appeared to be limited to the gastric cardia. This cancer may have arisen via a sequence of carditis and cardiac intestinal metaplasia, due primarily to the GERD and not to H. pylori infection.
authors.affiliation: Department of Internal Medicine, Niigata-prefectural Yoshida Hospital, Yoshidamachi, Niigataken, Japan. yagikazu@pop12.odn.ne.jp
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Yagi
authors.forename: Atsuo
authors.initials: A
authors.lastname: Nakamura
authors.forename: Atsuo
authors.initials: A
authors.lastname: Sekine
authors.forename: Manabu
authors.initials: M
authors.lastname: Oyamatsu
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tamiya
authors.forename: Hedenobu
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D000368:Aged; D002299:Cardia / Q000473:pathology*; D005743:Gastrectomy; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000601:surgery; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology