Cardiomyocyte ultrastructure in rats with different metabolizing capacities of the liver during acute myocardial infarction.
Electron microscopy of cardiomyocytes was performed on days 1, 3, and 7 after ligation of the coronary artery in rats previously divided according to liver metabolizing capacities into slowly and rapidly metabolizing animals. In rapidly metabolizing rats cardiomyocyte sarcoplasm contained large number of hyperplastic ribosomes and polysomes at the late stages of experiment, which attested to high activity of protein and RNA synthesis compared to slowly metabolizing rats. In slowly metabolizing animals edema of cardiomyocyte sarcoplasm and mitochondria was usually seen.
Saidov
A B
AB
Second Tashkent State Medical Institute.
Isroilov
R I
RI
D000818:Animals; D008099:Liver / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats