Microbial transformation of (+)-adrenosterone.
The microbial transformation of (+)-adrenosterone (1) by Cephalosporium aphidicola afforded three metabolites identified as androsta-1,4-diene-3,11,17-trione (2), 17beta-hydroxyandrost-4-ene-3,11-dione (3) and 17beta-hydroxyandrosta-1,4-diene-3,11-dione (4). The fermentation of 1 with Fusarium lini also produced metabolites 2 and 4, while the fermentation with Trichothecium roseum afforded metabolite 3. The structures of transformed products were determined by spectroscopic methods.
Musharraf
S Ghulam
SG
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan.
Atta-Ur-Rahman
Choudhary
M Iqbal
MI
Sultan
Sadia
S
D000164:Acremonium / Q000378:metabolism*; D000735:Androstenedione / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D000735:Androstenedione