TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity.
TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation.
Desplat-Jégo
Sophie
S
NICN CNRS FRE 2533, IFR Jean Roche, Université de la Méditerranée, 13 916 Cedex 20, Marseilles, France.
Varriale
Simone
S
Creidy
Rita
R
Terra
Rafik
R
Bernard
Dominique
D
Khrestchatisky
Michel
M
Izui
Shozo
S
Chicheportiche
Yves
Y
Boucraut
José
J
D000818:Animals; D051017:Apoptosis Regulatory Proteins; D001253:Astrocytes / Q000276:immunology / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D002478:Cells, Cultured; D002490:Central Nervous System / Q000254:growth & development / Q000276:immunology / Q000378:metabolism*; D000074049:Cytokine TWEAK; D018450:Disease Progression; D004198:Disease Susceptibility / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000276:immunology; D018836:Inflammation Mediators / Q000494:pharmacology*; D051379:Mice; D008822:Mice, Transgenic; D017628:Microglia / Q000276:immunology / Q000378:metabolism*; D012333:RNA, Messenger / Q000276:immunology / Q000378:metabolism; D048069:Tumor Necrosis Factors
D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D000074049:Cytokine TWEAK; D018836:Inflammation Mediators; D012333:RNA, Messenger; C491645:Tnfsf12 protein, mouse; D048069:Tumor Necrosis Factors