title: Effects of dietary restriction on growth, neurobehavior, and reproduction in developing Kunmin mice.
abstract: The effects of dietary restriction (DR) on growth, neurobehavior, and reproduction in developing Kunmin mice were investigated in this study. Male and female mice were fed a standard rodent diet ad libitum (control), 80% of control (20% DR), or 65% of control (35% DR) for 3 months. Body weight of DR mice was reduced relative to control except that of females in the 20% DR group (no difference as compared with control group). Learning and memory retention test in a Y maze demonstrated that DR increased learning, but not retention, in male mice, whereas neither learning nor retention was affected in females. The open-field test revealed no difference in exploratory activity in all groups. Reproductive assessment showed that 35% DR retarded the maturation of reproductive function and reduced fertility compared with other groups. Furthermore, both 20% and 35% DR led to a lower level of sperm motility and a higher level of abnormal sperm relative to control mice. These findings indicate that DR does not cause damaging effects on growth and neurobehavior, but imposes a risk to reproductive development events.
authors.affiliation: Department of Physiological Science, University of California at Los Angeles, Los Angeles, California 90095, USA. agwu@ucla.edu
authors.forename: Aiguo
authors.initials: A
authors.lastname: Wu
authors.forename: Fada
authors.initials: F
authors.lastname: Wan
authors.forename: Xiufa
authors.initials: X
authors.lastname: Sun
authors.forename: Yugu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002149:Energy Intake / Q000502:physiology; D004822:Epididymis / Q000254:growth & development; D005260:Female; D005298:Fertility / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology; D012737:Sex Factors; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology; D013737:Testis / Q000254:growth & development