Prevalence of clinical isolates of Escherichia coli producing inhibitor-resistant beta-lactamases at a University Hospital in Barcelona, Spain, over a 3-year period.
About 7% of 7,252 nonduplicated clinical Escherichia coli strains from a Spanish hospital showed reduced susceptibility to amoxicillin-clavulanate. Of these, 0.37% produced the IRTs TEM-30, TEM-31, TEM-33, TEM-34, TEM-37, TEM-40, TEM-51, and TEM-54; 5.3% were probable class C beta-lactamase overproducers; 0.8% were probable TEM-1 hyperproducers; 0.18% produced OXA-30; 0.15% overexpressed SHV-1; and 0.03% produced a PSE-1 enzyme.
Miró
Elisenda
E
Departament de Microbiologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma 08025 Barcelona, Spain. emiro@hsp.santpau.es
Navarro
Ferran
F
Mirelis
Beatriz
B
Sabaté
Montserrat
M
Rivera
Alba
A
Coll
Pere
P
Prats
Guillem
G
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D013030:Spain; D001618:beta-Lactamases / Q000235:genetics*
D019980:Amoxicillin-Potassium Clavulanate Combination; D001618:beta-Lactamases