The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis.
Scinderin (Sc), a Ca(2+)-regulated actin-binding protein, has been previously shown to control submembranous actin dynamics in regulated secretion. The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F-actin dynamics during secretion.
Lejen
T
T
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada. tlejen@uottawa.ca
Pene
T Dumitrescu
TD
Rosé
S D
SD
Trifaró
J-M
JM
D000199:Actins / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D019439:Chromaffin Cells / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D005089:Exocytosis; D018260:Gelsolin; D008840:Microfilament Proteins / Q000737:chemistry* / Q000502:physiology*; D018613:Microscopy, Confocal; D017434:Protein Structure, Tertiary; D014162:Transfection
D000199:Actins; D018260:Gelsolin; D008840:Microfilament Proteins; C065395:scinderin