title: Sequential regimen for early post-surgical infective endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA), unresponsive to standard antibiotic therapy: a case report.
abstract: We describe a patient with early post-surgical infective endocarditis due to methicillin-resistant Staphylococcus aureus, who was unsuitable for surgical reintervention and who failed standard antistaphylococcal therapy, but was successfully cured with a sequential regimen including quinupristin/dalfopristin and linezolid.
authors.affiliation: Institute of Infectious Diseases, University of Udine, Italy. pierluigi.viale@drmm.uniud.it
authors.forename: P
authors.initials: P
authors.lastname: Viale
authors.forename: C
authors.initials: C
authors.lastname: Scolari
authors.forename: P
authors.initials: P
authors.lastname: Colombini
authors.forename: F
authors.initials: F
authors.lastname: Cristini
authors.forename: B
authors.initials: B
authors.lastname: Cadeo
authors.forename: L
authors.initials: L
authors.lastname: Pagani
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology*; D013504:Cardiovascular Surgical Procedures / Q000009:adverse effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D000069349:Linezolid; D016106:Methicillin Resistance; D008944:Mitral Valve Insufficiency / Q000601:surgery; D023303:Oxazolidinones / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology; D014769:Virginiamycin / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D000069349:Linezolid