Extraventricular neurocytoma: morphological and immunohistochemical considerations on differential diagnosis.
Neurocytoma is an unusual neuronal tumor especially affecting young people. It commonly arises in the ventricles and has a benign outcome. Herein, we report on a rare case of extraventricular neurocytomas (right parietal lobe) in a young girl admitted to hospital for a cranial trauma subsequent to a seizure. The tumor, radiologically well-circumscribed, cystic and enhancing, was surgically excised. The patient, who received no post surgical treatment, is alive and well after 18 months of follow-up. Pathological examination showed a well-differentiated lesion composed of uniform, round cells with perinuclear halos in a neuropil background and immunohistochemically positive for neuronal markers (synaptophysin, neuron-specific enolase, neurofilaments). The authors emphasize the role of the morphological and immunohistochemical evaluations to recognize this rare tumor.
Buccoliero
Anna Maria
AM
Dipartimento di Patologia Umana e Oncologia, Università degli Studi di Firenze, Italy.
Caldarella
Adele
A
Ammannati
Franco
F
Mennonna
Pasquale
P
Taddei
Antonio
A
Taddei
Gian Luigi
GL
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D018306:Neurocytoma / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009837:Oligodendroglioma / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D011859:Radiography; D012640:Seizures / Q000209:etiology