Does insulin resistance cause atherosclerosis in the post-prandial period?
Insulin resistance would appear to be a causal factor for the development of early occlusive atherosclerosis. This paper proposes that post-prandial insulin resistance, in association with raised levels of cortisol and catecholamines, plays the major role, and may even be the primary causative factor. Therefore, factors that lead to insulin resistance in the post-prandial period, specifically stress, will accelerate the development of CHD. This may explain the low rate of CHD in France, as their eating habits (in common with many other Mediterranean countries) are more relaxed than those in Northern Europe.
Kendrick
Malcolm
M
malcolm@llp.org.uk
D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D002395:Catecholamines / Q000502:physiology; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D005247:Feeding Behavior / Q000502:physiology; D005602:France; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D008954:Models, Biological; D019518:Postprandial Period / Q000502:physiology; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology
D002395:Catecholamines; D006854:Hydrocortisone