Prospective study of decreased bone mineral density in patients with cervical cancer without bone metastases: a preliminary report.
BACKGROUND
In women, osteoporosis is a common chronic disease that induces spinal compression and femoral neck fractures, resulting in life-threatening complications. It is very important to identify risk factors in order to prevent this disorder. Bone destruction is a well-recognized complication in a variety of neoplasms without bone metastasis. Therefore, in the present study, we investigated the spinal bone mineral density (BMD) in patients with cervical cancer without bone metastases.


METHODS
This was a prospective study. Before any treatment, the BMD in 50 patients with invasive cervical cancer without bone metastases was measured by dual-energy X-ray absorptiometry and compared with those in 50 control women with the same distribution of age, height, weight and body mass index. None of the patients and control women had reached menopause.


RESULTS
The BMD in patients with cervical cancer was significantly lower (P < 0.05) than those of control women. However, serum levels of calcium and phosphate were not significantly different between the patients with cervical cancer and control women.


CONCLUSIONS
Our preliminary results suggest that patients with invasive cervical cancer have a lower BMD, resulting in an increased risk of osteoporosis.
Hung
Yao-Ching
YC
Department of OBS/GYN, China Medical College Hospital, Taichung, Taiwan.
Yeh
Lian-Shung
LS
Chang
Wei-Chun
WC
Lin
Cheng-Chieh
CC
Kao
Chia-Hung
CH
D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D001859:Bone Neoplasms; D005260:Female; D006801:Humans; D010024:Osteoporosis / Q000209:etiology; D011446:Prospective Studies; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000503:physiopathology*