title: Sebaceous carcinoma in children.
abstract: Sebaceous carcinoma is a rare malignant tumor derived from the epithelium of sebaceous glands. It potentially may develop from any sebaceous gland, but most commonly occurs in the periorbital area. We report a case of sebaceous carcinoma in a 14-year-old girl who was first seen with an asymptomatic 2.5 x 2.3-cm firm, multilobulated cutaneous nodule on the anterior thorax, which had been present for 1 year. She was adopted, and no family history is available. A skin biopsy specimen revealed a poorly differentiated infiltrative carcinoma involving the dermis and subcutaneous fat and focally involving the epidermis. Tumor cells had sebaceous and squamous differentiation. A diagnosis of sebaceous carcinoma was made. She was treated by surgical excision with a 2-cm margin. Further work-up showed no evidence of Muir-Torre syndrome.
authors.affiliation: Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
authors.forename: Nayomi E
authors.initials: NE
authors.lastname: Omura
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Collison
authors.forename: Ann E
authors.initials: AE
authors.lastname: Perry
authors.forename: Laura M
authors.initials: LM
authors.lastname: Myers
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome