title: Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions.
abstract: The reorganization of membrane, cytoskeletal and signaling molecules during immune interactions is critical for the generation of immune response. At the initiation of the T cell-antigen presenting cell (APC) interaction, antigen-independent weak adhesion forces allow the scanning of the APC surface by the T cell receptor for specific antigens. The stabilization of T cell-APC conjugates involves the segregation of membrane and intracellular signaling proteins, driven by reorganization of membrane microdomains and cytoskeletal changes. In early T cell-APC cognate interactions, the microtubular cytoskeleton undergoes drastic changes that lead to microtubule-organizing center (MTOC) reorientation to the vicinity of the cell-cell contact area. Recent data on the dynamics of MTOC redistribution and its influence in T cell-APC conjugate stabilization, together with the description of an increasing number of signaling molecules associated to this complex, underscore the key role of MTOC translocation in the T cell response. We focus on the mechanisms that control the early MTOC reorientation during T cell-APC interaction and the relevance of this process to T cell activation.
authors.affiliation: Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Sancho
authors.forename: Miguel
authors.initials: M
authors.lastname: Vicente-Manzanares
authors.forename: María
authors.initials: M
authors.lastname: Mittelbrunn
authors.forename: María C
authors.initials: MC
authors.lastname: Montoya
authors.forename: Mónica
authors.initials: M
authors.lastname: Gordón-Alonso
authors.forename: Juan M
authors.initials: JM
authors.lastname: Serrador
authors.forename: Francisco
authors.initials: F
authors.lastname: Sánchez-Madrid
mesh_terms: D000205:Actomyosin / Q000276:immunology*; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D002450:Cell Communication / Q000276:immunology; D018385:Centrosome / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D020935:MAP Kinase Signaling System / Q000276:immunology; D051379:Mice; D022101:Microtubule-Organizing Center / Q000276:immunology*; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D011948:Receptors, Antigen, T-Cell; D000205:Actomyosin