title: Chromosomal localization and genomic organization of the human Linker for Activation of T cells (LAT) gene.
abstract: We have mapped the LAT gene by radiation hybrid mapping and fluorescence in situ hybridization to chromosome 16p11.2. The complete cDNA sequence of LAT was generated using assembled sequences of cDNA fragments already available. BLAST analysis using the cDNA sequence led to the identification of BAC clone CTB-134H23 (GenBank Accession No. AC112166). The genomic structure of the human LAT gene consists of 11 exons, encompassing 5.7 kb. Alternative splicing variants were identified.
authors.affiliation: Institute of Medical Biology and Human Genetics, University of Graz, Graz, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Windpassinger
authors.forename: P M
authors.initials: PM
authors.lastname: Kroisel
authors.forename: K
authors.initials: K
authors.lastname: Wagner
authors.forename: E
authors.initials: E
authors.lastname: Petek
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D018076:DNA, Complementary; D006801:Humans; D006822:Hybrid Cells / Q000528:radiation effects; D017404:In Situ Hybridization, Fluorescence; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D018076:DNA, Complementary; C110810:LAT protein, human; D008565:Membrane Proteins; D010750:Phosphoproteins