[Effects of active fractions from Lycopus lucidus L. F04 on erythrocyte rheology [correction of erythrocyterheology]].
Objective. To study the effects of active fractions from Lycopus lucidus (L. F04) on erythrocyte rheology so as to investigate its mechanism of promoting blood circulation and removing blood stasis. Method. The effects of L. F04 on erythrocytes deformability, aggregation, liquidity of membrane were examined in the present study and the blood stasis animal model of rats made by injecting high molecular weight dextran (HMWD) was used. Result. HMWD injection decreased red blood cells deformability (P<0.05) and liquidity of membrane (P<0.01) and increased erythrocytes aggregation (P<005). Compared with the model, both L. F04 0.612 g/kg and 0.306 g/kg improved red blood cells deformability (P<0.05), inhibited erythrocytes aggregation (P<0.05), and showed the trend of improving liquidity of membrane. But there was no concentration-dependence. Conclusion. L. F04 can significantly improve the deviant erythrocyte rheology characteristics.
Shi
Hong-zhi
HZ
Institute of Space Medico-Engineering, Beijing, China.
Gao
Nan-nan
NN
Li
Yong-zhi
YZ
Yu
Jing-guang
JG
Fan
Quan-chun
QC
Bai
Gui-e
GE
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D018056:Hemorheology / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects; D031333:Lycopus; D051381:Rats; D017208:Rats, Wistar
D000925:Anticoagulants; D003911:Dextrans; D004365:Drugs, Chinese Herbal