Genotoxicity of hyperbaric oxygen.
Hyperbaric oxygen (HBO) treatment is applied as a therapy for a wide variety of diseases with symptoms caused by lack of oxygen in the target tissues. However, it is known that exposure to high concentrations of oxygen may lead to oxidative stress and cause cell and tissue damage. Oxygen toxicity and possible cancer-promoting effects of HBO therapy have been a matter of serious concern. Although a cancer-inducing effect of HBO was not found to date, recent studies clearly indicated an induction of oxidative DNA damage in blood cells of healthy subjects after HBO under therapeutic conditions. The biological significance of this finding has been investigated in a series of in vitro and in vivo tests. This review summarizes these studies and critically discusses potential adverse genetic effects of HBO therapy. Furthermore, since an induction of anti-oxidative defense mechanisms has been determined after HBO exposure, a modified treatment regimen of HBO therapy is proposed which avoids genotoxic effects.
Speit
Günter
G
Abteilung Humangenetik, Universitätsklinikum Ulm, Albert Einstein Allee 11, D-89070, Ulm, Germany. guenter.speit@medizin.uni-ulm.de
Dennog
Claudia
C
Radermacher
Peter
P
Rothfuss
Andreas
A
D000818:Animals; D020552:Comet Assay; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000378:metabolism; D009154:Mutation; D018384:Oxidative Stress; D010100:Oxygen / Q000633:toxicity*
D004247:DNA; D007041:Hypoxanthine Phosphoribosyltransferase; D010100:Oxygen