Insulin feedback action on pancreatic beta-cell function.
Pancreatic beta-cell function is essential for the regulation of glucose homeostasis and its impairment leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from neural and humoral components and intraislet cell-cell communication act together to guarantee an appropriate pancreatic beta-cell function. Data obtained over the last 5 years in several laboratories have revitalized a controversial concept, namely the autocrine feedback action of secreted insulin on beta-cell function. While, historically, insulin was suggested to exert a negative effect on beta-cells, recent data provide evidence for a positive role of insulin in transcription, translation, ion flux, insulin secretion and beta-cell survival.
Leibiger
Ingo B
IB
The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital L3, Karolinska Institutet, S-171 76 Stockholm, Sweden. ingo.leibiger@molmed.ki.se
Leibiger
Barbara
B
Berggren
Per-Olof
PO
D000818:Animals; D019898:Autocrine Communication; D002118:Calcium / Q000378:metabolism; D025461:Feedback, Physiological; D006801:Humans; D007328:Insulin / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D000078790:Insulin Secretion; D017136:Ion Transport; D007515:Islets of Langerhans / Q000502:physiology*; D051379:Mice; D014176:Protein Biosynthesis; D051381:Rats; D014158:Transcription, Genetic
D007328:Insulin; D002118:Calcium