title: Dolichol levels in younger and older rat hearts heterotopically transplanted in younger recipients.
abstract: Dolichol (D) levels increase dramatically in older tissue. An understanding of the exchangeability of D between tissues may be essential in order to understand the mechanism of the abnormal accumulation associated with aging. The question was investigated by the use of organ transplantation. D-poor hearts donated by 3-mon-old and D-rich by 22-mon-old male Lewis rats were transplanted heterotopically in 3-mon-old syngenic recipients, whose peripheral tissues and liver were poor in D. Native and transplanted hearts were taken 7 and 21 d after surgery. Native hearts of 3-mon- and 22-mon-old male Lewis rats served as control. D concentration and quantity were higher in older than in younger native hearts as expected. In the transplanted hearts, the quantity of D was unchanged, irrespective of the age of the donor and of the time of transplantation, whereas D concentration increased because of the remarkable disuse atrophy. No changes in D were observed in recipients' tissues. It is concluded that dolichol is not redistributed via circulation from the transplanted heart to the tissues and liver of the younger recipient.
authors.affiliation: Dipartimento di Patologia sperimentale, Biotecnologie mediche, Infettivologia e Epidemiologia, University of Pisa, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cavallini
authors.forename: Ilaeia
authors.initials: I
authors.lastname: Parentini
authors.forename: Rossella
authors.initials: R
authors.lastname: Di Stefano
authors.forename: Marco
authors.initials: M
authors.lastname: Maccheroni
authors.forename: Matilde
authors.initials: M
authors.lastname: Masini
authors.forename: Maria
authors.initials: M
authors.lastname: Pollera
authors.forename: Zina
authors.initials: Z
authors.lastname: Gori
authors.forename: Franco
authors.initials: F
authors.lastname: Mosca
authors.forename: Ettore
authors.initials: E
authors.lastname: Bergamini
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004286:Dolichols / Q000032:analysis*; D016027:Heart Transplantation; D008297:Male; D009206:Myocardium / Q000737:chemistry* / Q000166:cytology; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D014019:Tissue Donors
chemical_list: D004286:Dolichols