Molecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea.
CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine beta-synthase (CBS) gene from Saccharomyces cerevisiae. Our studies indicated that M. grisea can utilize homocysteine and methionine through a CBS-independent pathway. The results also revealed responses of M. grisea to homocysteine that are reminiscent of human homocystinuria.
Lo
Sze Chung Clive
SC
Microbial Research, Paradigm Genetics, Inc., Research Triangle Park, North Carolina 27709, USA. clo@paragen.com
Hamer
Lisbeth
L
Hamer
John E
JE
D000595:Amino Acid Sequence; D003540:Cystathionine / Q000737:chemistry; D003541:Cystathionine beta-Synthase / Q000737:chemistry / Q000235:genetics*; D005800:Genes, Fungal; D006710:Homocysteine / Q000494:pharmacology; D020082:Magnaporthe / Q000235:genetics* / Q000254:growth & development; D024101:Mitochondrial Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D010935:Plant Diseases / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D015534:Trans-Activators / Q000235:genetics; D014805:Vitamin B 12 / Q000378:metabolism
C060724:CBS1 protein, S cerevisiae; D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D006710:Homocysteine; D003540:Cystathionine; D003541:Cystathionine beta-Synthase; D014805:Vitamin B 12