title: Effect of low protein and low energy diet on physiological status and digestibility of F344 rats.
abstract: A long-term raising study was carried out on male F344/DuCrj rats with three low protein (Crude Protein (CP); 14.5, 11.5, 8.5%) and low energy (Digestible Energy (DE); 2.0 kcal/g) diets from 4 to 104 weeks of age. In rats fed the 8.5% CP diet, body weight and digestible crude protein (DCP) consumption at 10 weeks of age were lower (P < 0.05) but the body weight at 50 weeks of age was higher (P < 0.05) than in the other groups. In rats fed the 8.5% CP diet the crude fat digestibility was higher (P < 0.05), and the CP/nitrogen-corrected metabolizable energy (MEn) ratio was low. On the other hand, the mean survival time at 80 weeks of age was shorter in rats fed the 8.5% CP diet (P < 0.05).
authors.affiliation: Research & Development Center, Nosan Corporation, 5246 Takura, Tsukuba 300-2615, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kaneko
authors.forename: Seinosuke
authors.initials: S
authors.lastname: Ohshima
authors.forename: Seigo
authors.initials: S
authors.lastname: Shumiya
authors.forename: Ei
authors.initials: E
authors.lastname: Sakaguchi
mesh_terms: D000375:Aging / Q000502:physiology; D000822:Animal Husbandry; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight; D031204:Caloric Restriction; D018753:Diet, Protein-Restricted; D004063:Digestion; D004734:Energy Metabolism; D008136:Longevity; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344 / Q000502:physiology*; D013997:Time Factors