[Respiratory and hemodynamic responses to microinjections of opioids into the solitary tract nucleus].
Microinjections of morphin and leu-enkephaline into the solitary tract nucleus of anaesthetised rats induced a dose-dependent decrease in tidal volume and in external intercostal muscle activity. In addition, leu-enkephaline and -endorphine decreased the respiration frequency. The respiratory effects were accompanied by a decrease in the mean blood pressure and heart rate. Naloxone administration exerted an opposite effect. The data obtained suggests an involvement of opioid peptides in respiratory and circulatory control via the solitary tract nucleus.
Iniushkin
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AN
State University, 443011 Samara, 1, Pavlov St., Russia.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004743:Enkephalin, Leucine / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009020:Morphine / Q000494:pharmacology; D009292:Narcotic Antagonists; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D017552:Solitary Nucleus / Q000378:metabolism / Q000502:physiology*; D001615:beta-Endorphin / Q000494:pharmacology
D009292:Narcotic Antagonists; D009294:Narcotics; D004743:Enkephalin, Leucine; D001615:beta-Endorphin; D009020:Morphine