Structure-activity relationship of a new class of anti-hepatitis B virus agents.
N-Nonyl-deoxy-galactonojirimycin (N-nonyl-DGJ) has been shown to reduce the amount of hepatitis B virus (HBV) produced by tissue cultures under conditions where cell viability is not affected. We show here that the compound N-nonyl-DGJ was effective against lamivudine-resistant HBV mutants bearing the YMDD motif in the polymerase gene, consistent with the compound's activity being distinct from those of nucleoside inhibitors. To better understand the chemical structures that influence its antiviral activity, a series of imino sugar derivatives were made and tested for their antiviral activity against HBV. This work suggests that the antiviral activity of the alkovirs requires an alkyl chain length of at least eight carbons but that the galactose-based head group can be modified with little or no loss in activity.
Mehta
Anand
A
Department of Biochemistry and Molecular Pharmacology, The Jefferson Center, Jefferson Medical College, Doylestown, Pennsylvania 18901-2697, USA. anand.mehta@mail.tju.edu
Conyers
Bertha
B
Tyrrell
D L J
DL
Walters
Kathie-Anne
KA
Tipples
Graham A
GA
Dwek
Raymond A
RA
Block
Timothy M
TM
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D005690:Galactose / Q000031:analogs & derivatives*; D006515:Hepatitis B virus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D005690:Galactose