Preliminary results of intraoperative daunorubicin in strabismus surgery.
OBJECTIVE
To evaluate the safety and efficacy of intraoperative daunorubicin (0.02%) for patients with strabismus undergoing a second surgical procedure.


METHODS
Twenty-four patients with strabismus undergoing a second surgical procedure were randomly divided into two groups. In group A, daunorubicin 0.02% was applied subconjunctivally over the surface of the muscle and bare sclera for 3 minutes by cellulose sponge and then washed off thoroughly. In group B, distilled water was applied for 3 minutes in place of daunorubicin after the removal of adhesions.


RESULTS
Satisfactory alignment in primary position with improved ocular motility was obtained in 80% of the patients in group A compared with 40% of the patients in group B after 12 months of follow-up (P = .16).


CONCLUSIONS
We recommend intraoperative daunorubicin 0.02% for 3 minutes as an adjunct for better results in patients with strabismus undergoing a second surgical procedure.
Dadeya
Subhash
S
Guru Nanak Eye Center, Maulana Azad Medical College, New Delhi, India.
Kamlesh
Fatima
Shibal
S
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003630:Daunorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D005133:Eye Movements; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D011184:Postoperative Period; D011446:Prospective Studies; D012086:Reoperation; D012449:Safety; D013285:Strabismus / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome
D003630:Daunorubicin