title: Phospholipid autoantibodies: time for a new immuno-assay?
abstract: Antiphospholipid (aPL) antibodies are a wide and heterogeneous group of closely related immunoglobulins that have specificity for a number of phospholipids (PLs), PL-binding proteins, including beta2 glycoprotein I (beta2GP1), prothrombin, and PL-protein complexes. Antiphospholipid antibodies are currently detected by a standard solid-phase immunoassay such as anticardiolipin (aCL) antibodies. Although the association between aCL antibodies and thrombosis is well recognized, their role in stroke pathogenesis, and the possibility that they are an independent stroke risk factors in the general stroke population, remains to be determined. There are other negatively charged PL, largely represented within the cellular membrane and involved in the coagulation. Different studies have demonstrated a positive correlation among other aPL and stroke.
authors.affiliation: Department of Neuroscience, University of Perugia, Italy. vcaso@hotmail.com
authors.forename: Valeria
authors.initials: V
authors.lastname: Caso
authors.forename: Paolo
authors.initials: P
authors.lastname: Panarelli
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Albi
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Viola-Magni
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
authors.forename: Virgilio
authors.initials: V
authors.lastname: Gallai
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D020521:Stroke / Q000175:diagnosis / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid; D001324:Autoantigens; D015415:Biomarkers