5-hydroxyramulosin, a new natural product produced by Phoma tropica, a marine-derived fungus isolated from the alga Fucus spiralis.
The fungus Phoma tropica was isolated from the inner tissue of the marine brown alga Fucus spiralis. After large-scale cultivation the fungus was investigated for its secondary metabolite content and found to contain the new natural product 5-hydroxyramulosin ( 1) together with 7-methoxycoumarin. Both structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR, and in the case of 1, a single crystal X-ray diffraction analysis.
Osterhage
Claudia
C
König
Gabriele M
GM
Jones
Peter G
PG
Wright
Anthony D
AD
D001203:Ascomycota; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D056890:Eukaryota; D017245:Foscarnet / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*
C470479:5-hydroxyramulosin; D003374:Coumarins; D010936:Plant Extracts; D018894:Reverse Transcriptase Inhibitors; D017245:Foscarnet; D054303:HIV Reverse Transcriptase