title: [Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis].
abstract: The aim of this meta-analysis based on the literature was to gather all evidence of randomized clinical trials to assess the efficacy of adenosylmethionine (SAM) and oxaceprol in the treatment of osteoarthritis. Findings in MEDLINE and EMBASE were added to publications catalogued by the AkdA and a reference search. The meta-analysis was based mostly on pain scores but also on pain and function scores. We used the fixed effects and the random effects model.A superiority of SAM vs placebo ( n=468) could not be shown; the 95% CI of standardized difference of pain scores was (-0.89, 0.12). The comparison of SAM vs NSAIDs with seven studies ( n=850) did not show a difference: (-0.59, 0.19). This cannot be seen as proof for equivalence. A post-hoc analysis of SAM vs ibuprofen gave nearly a positive result for SAM: (-0.43, 0.02). No adequate placebo-controlled RCT was found. There was no significance for a difference between oxaceprol and NSAIDs using the four trials found (two diclofenac and two ibuprofen); the 95% CI of standardized difference of pain and function scores was (-0.19, 0.27). Since only a few trials with heterogeneous results were found which mostly have a low quality of the studies and/or publications, the results must be interpreted very carefully. The meta-analysis does not give enough evidence for the efficacy of SAM and oxaceprol for treating the symptoms of osteoarthritis, but it might be that there is a comparable effect to other NSAIDs.
authors.affiliation: Abteilung Medizinische Biometrie, Universität Heidelberg, Germany. witte@imbi.uni-heidelberg.de
authors.forename: S
authors.initials: S
authors.lastname: Witte
authors.forename: R
authors.initials: R
authors.lastname: Lasek
authors.forename: N
authors.initials: N
authors.lastname: Victor
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D004008:Diclofenac / Q000627:therapeutic use; D006801:Humans; D006909:Hydroxyproline / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007052:Ibuprofen / Q000627:therapeutic use; D010003:Osteoarthritis / Q000188:drug therapy*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D012436:S-Adenosylmethionine / Q000627:therapeutic use*; D013810:Therapeutic Equivalency
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D004008:Diclofenac; D012436:S-Adenosylmethionine; C012393:oxaceprol; D006909:Hydroxyproline; D007052:Ibuprofen