title: Calibrated serological techniques demonstrate significant different serum response rates to an oral killed cholera vaccine between Swedish and Nicaraguan children.
abstract: Serum responses to oral cholera vaccines were assessed in three paediatric vaccine trials, two in León, Nicaragua and one in Stockholm, Sweden. A calibrated anti-cholera toxin B subunit (CTB) IgA ELISA was used together with an assay for vibriocidal antibodies. Swedish children had lower pre-vaccination levels of antibody, but serum responses were more pronounced in Swedish children than in Nicaraguan children. Post-vaccination levels of anti-toxin antibody were generally above those found after natural infections with enterotoxigenic Escherichia coli, that cross-reacts serologically with Vibrio cholerae. Adverse events seen after vaccination were generally mild and of little clinical significance.
authors.affiliation: Swedish Institute for Infectious Disease Control, Solna, Sweden.
authors.forename: H O
authors.initials: HO
authors.lastname: Hallander
authors.forename: M
authors.initials: M
authors.lastname: Paniagua
authors.forename: F
authors.initials: F
authors.lastname: Espinoza
authors.forename: P
authors.initials: P
authors.lastname: Askelöf
authors.forename: E
authors.initials: E
authors.lastname: Corrales
authors.forename: M
authors.initials: M
authors.lastname: Ringman
authors.forename: J
authors.initials: J
authors.lastname: Storsaeter
mesh_terms: D000284:Administration, Oral; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D002138:Calibration; D002648:Child; D002675:Child, Preschool; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009527:Nicaragua; D012449:Safety; D012698:Serologic Tests; D013548:Sweden; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology*; D014734:Vibrio cholerae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D015164:Vaccines, Inactivated