A correlative study between 99mTc-ESTCPTA and 99mTc-MIBI in rats.
Tissue distribution of the 99mTc labeled derivative of the estrogen compound 3,17-alpha-estradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-l-(4-methylbenzoic acid) ester (ESTCPTA), which has an 3,17-alpha-estradiolyl propinol coupled to l-(4-methylbenzoic acid)1,4,8,11-tetraazacyclotetradecane (CPTA), was compared to 99mTc-MIBI (methoxyisobutyl isonitrile) in female Albino Wistar rats. Tissues of interest included lung, liver, heart, kidneys, spleen, stomach, intestines, pancreas, muscle, blood, breast, ovary, fat, and uterus. 99mTc-ESTCPTA uptake by the uterus and ovary, as ER-rich tissues, was highly selective. Maximum uptakes for 99mTc-MIBI and 99mTc-ESTCPTA are 90 min in breast, ovary and uterus. The pancreas also showed significant receptor saturated and unsaturated ratios for 99mTc-ESTCPTA. Results are sufficiently encouraging to generate further evaluation of these and related compounds as possible estrogen receptor based tumor imaging and therapeutic agents in estrogen-rich tissues.
Unak
Perihan
P
Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Turkey. unak@bornova.ege.edu.tr
Enginar
Huseyin
H
Biber
F Zümrüt
FZ
Lambrecht
Fatma Yurt
FY
Aslani
Mahmoud A A
MA
Ozkilic
Hayal
H
D000818:Animals; D001940:Breast / Q000000981:diagnostic imaging / Q000378:metabolism; D004958:Estradiol / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005260:Female; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010053:Ovary / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000378:metabolism; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014599:Uterus / Q000000981:diagnostic imaging / Q000378:metabolism
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D011960:Receptors, Estrogen; C470034:technetium Tc 99m 3,17-estradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid) ester; D004958:Estradiol; D017256:Technetium Tc 99m Sestamibi