title: Does a preexisting anxiety disorder predict response to paroxetine in irritable bowel syndrome?
abstract: Irritable bowel syndrome (IBS) is the most common disorder in patients seen by gastroenterologists. Twenty subjects with IBS diagnosed with the Rome criteria were treated for 12 weeks with 20-40 mg/day of paroxetine (mean dose=31 mg/day). At baseline, 10 patients had a lifetime history of an anxiety disorder, and 10 patients did not have such a history. Both groups had similar improvement in abdominal pain, constipation, diarrhea, incomplete emptying, and bloating/ abdominal distension. Paroxetine was very well tolerated.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. masan001@mc.duke.edu
authors.forename: Prakash S
authors.initials: PS
authors.lastname: Masand
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Schwartz
authors.forename: David
authors.initials: D
authors.lastname: Kaplan
authors.forename: Subhdeep
authors.initials: S
authors.lastname: Virk
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hameed
authors.forename: Kari
authors.initials: K
authors.lastname: Lockwood
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D003109:Colonic Diseases, Functional / Q000188:drug therapy* / Q000523:psychology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012650:Self Disclosure; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors