Effects of muramyl dipeptide glycosides on lymphocyte proliferation and production of interleukin-2.
We studied the effect of new muramyl dipeptide glycosides with different structure of aglycon and configuration glycoside bond on spontaneous and mitogen-induced proliferation of mouse splenocytes and production of interleukin-2 by these cells. Biological activity of muramyl dipeptide beta-glycosides with aliphatic, carbocyclic, adamantile, and phenol aglycons is higher than that of the original compound, while alpha-glycosylation decreases the immunostimulating effect of this glycopeptide.
Kalyuzhin
O V
OV
Laboratory of Cell Immunopathology and Biotechnology, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow.
Zemlyakov
A E
AE
Kalyuzhina
E V
EV
Shkalev
M V
MV
Nelyubov
M V
MV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry; D007376:Interleukin-2 / Q000096:biosynthesis*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice
D006027:Glycosides; D007376:Interleukin-2; D000119:Acetylmuramyl-Alanyl-Isoglutamine