title: Comparison of two fibrin glues in anastomoses and skin closure.
abstract: To control intra-operative haemorrhage, fibrin glues are preferred by many surgeons because of their biological advantages and convenience of application. Manufacturers have developed a few kinds of fibrin glues with a little difference in their composition. This study was to compare the effectiveness of two commercially available fibrin glues; Greenplast (Green Cross P. D. Company, Yongin, Korea) and Tisseel (Baxter-Immuno AG, Vienna, Austria). They were applied experimentally to several kinds of surgery in dogs - renal vessel anastomosis, partial splenectomy, intestinal anastomosis and incision skin wound - and evaluated for their haemostatic and adhesive effects. When the two glues were applied in renal vessel anastomosis, the amount of haemorrhage in artery and vein decreased significantly. They also decreased the haemorrhage in partial splenectomy. At 10 min after application of the glues to an incision skin wound, the tensile strengths developed were significantly higher than that of control. The present study indicates that two-component fibrin glues have a haemostatic effect as a mechanical barrier in renal vessel anastomosis and an adhesive effect in the early stage of incision skin wound closure, and the two glues have similar effects with no complications.
authors.affiliation: Department of Veterinary Surgery, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Seoul National University, Korea.
authors.forename: W
authors.initials: W
authors.lastname: Park
authors.forename: W H
authors.initials: WH
authors.lastname: Kim
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: D Y
authors.initials: DY
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Choi
authors.forename: J W
authors.initials: JW
authors.lastname: Huh
authors.forename: H M
authors.initials: HM
authors.lastname: Sung
authors.forename: I S
authors.initials: IS
authors.lastname: Kim
authors.forename: O K
authors.initials: OK
authors.lastname: Kweon
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods / Q000662:veterinary*; D000818:Animals; D062109:Dermatologic Surgical Procedures; D004285:Dogs / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D013156:Splenectomy / Q000379:methods / Q000662:veterinary; D013718:Tensile Strength
chemical_list: D015718:Fibrin Tissue Adhesive