Pancytopenia responding to treatment of hyperthyroidism: a clinical case and review of the literature.
A 46-year-old-man received high dose chemotherapy and an autologous stem-cell transplant for multiple plasmacytoma. He had a prolonged period of pancytopenia post-transplantation, which was thought to be due to a suboptimal dose of transplanted stem cells in combination with the effects of interferon therapy and an altered bone marrow microenvironment. Twenty-eight months after the transplant he was found to be hyperthyroid. Anti-thyroid therapy has led to a sustained improvement in his pancytopenia.
Shaw
B
B
Department of Haematology, Royal Free Hospital, London, UK.
Mehta
A B
AB
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001416:Back Pain / Q000209:etiology; D002231:Carbimazole / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy; D006177:Gynecomastia / Q000209:etiology; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D010198:Pancytopenia / Q000209:etiology*; D036102:Peripheral Blood Stem Cell Transplantation; D012272:Ribs; D013125:Spinal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D013904:Thoracic Vertebrae; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D014750:Vincristine / Q000008:administration & dosage
D018906:Antineoplastic Agents, Alkylating; D014750:Vincristine; D004317:Doxorubicin; D002231:Carbimazole; D003520:Cyclophosphamide; D008558:Melphalan; D008775:Methylprednisolone