title: Elicitation of transient lower oesophageal sphincter relaxations in response to gastric distension and meal ingestion.
abstract: The aim of this study was to compare the effect of graded gastric barostat distension and meal-induced fundic relaxation on the elicitation of transient lower oesophageal sphincter relaxation (TLOSR). In 15 healthy subjects, stepwise fundic distension and oesophageal manometry were performed simultaneously. Next, the effect of meal ingestion on proximal stomach volume and lower oesophageal sphincter function was studied. During stepwise barostat distension of the proximal stomach, a significant linear correlation between intragastric pressure (r = 0.91; P < 0.01) and the TLOSR rate during inflation and subsequent deflation (r = 0.96; P < 0.01) was found. A similar relationship was found for volume. In addition, after meal ingestion, the TLOSR rate increased significantly from 1.40 +/- 3 to 5.4 +/- 1.5 h-1 (P < 0.01) and 5.2 +/- 1.7 h-1 (P < 0.01), respectively, during the first and second 30-min postprandially. However, at similar calculated intragastric volumes, barostat distension led to a significantly higher TLOSR rate than the meal. Similarly, distension-induced increase in gastric wall tension, estimated from the measured bag pressure and volume using Laplace's law, was associated with significantly higher TLOSR rates (P < 0.01). In conclusion, the rate of TLOSRs in healthy volunteers is directly related to the degree of proximal gastric distension and pressure-controlled barostat distension is a more potent trigger of TLOSRs than a meal. The latter finding suggests that tension receptor activation is an important stimulus for TLOSRs.
authors.affiliation: Department of Surgery, Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands.
authors.forename: R C H
authors.initials: RC
authors.lastname: Scheffer
authors.forename: L M A
authors.initials: LM
authors.lastname: Akkermans
authors.forename: J E
authors.initials: JE
authors.lastname: Bais
authors.forename: J M M
authors.initials: JM
authors.lastname: Roelofs
authors.forename: A J P M
authors.initials: AJ
authors.lastname: Smout
authors.forename: H G
authors.initials: HG
authors.lastname: Gooszen
mesh_terms: D000328:Adult; D004943:Esophagogastric Junction / Q000502:physiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D006801:Humans; D008297:Male; D008365:Manometry; D009126:Muscle Relaxation / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology*; D011312:Pressure; D013270:Stomach / Q000502:physiology*