title: Efficacy of moxidectin 6-month injectable and milbemycin oxime/lufenuron tablets against naturally acquired trichuris vulpis infections in dogs.
abstract: Efficacy of moxidectin injection (ProHeart 6 Sustained Release Injectable for Dogs, Fort Dodge Animal Health) against naturally acquired infections of Trichuris vulpis was compared with that of milbemycin oxime/lufenuron tablets (Sentinel Flavor Tabs, Novartis Animal Health). Eighteen dogs infected with T. vulpis were ranked by egg counts and randomly allocated to treatment with moxidectin (170 micro g/kg), milbemycin (500 micro g/kg)/lufenuron (10 mg/kg), or to an untreated control group (six dogs per treatment). Dogs were euthanized for worm counting 7 days after treatment. Efficacy of milbemycin/lufenuron against T. vulpis was 99.6 %, compared with 67.5 % for moxidectin. The commercial formulation of milbemycin oxime/lufenuron provided excellent control of whipworm infection, whereas moxidectin demonstrated variable efficacy against this parasite.
authors.affiliation: CHK-R and D, Stanwood, MI 49346, USA.
authors.forename: Dwight D
authors.initials: DD
authors.lastname: Bowman
authors.forename: Walter
authors.initials: W
authors.lastname: Legg
authors.forename: David G
authors.initials: DG
authors.lastname: Stansfield
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D001344:Autopsy; D001549:Benzamides / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D007267:Injections; D018942:Macrolides; D008297:Male; D013607:Tablets / Q000627:therapeutic use; D014257:Trichuriasis / Q000188:drug therapy* / Q000469:parasitology; D014258:Trichuris / Q000187:drug effects / Q000302:isolation & purification; D005466:Fluorocarbons
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D001549:Benzamides; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D018942:Macrolides; D013607:Tablets; C070364:fluphenacur; D005466:Fluorocarbons; C027837:moxidectin