title: Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature.
abstract: The authors report an exceedingly rare case of a patient harboring a primary, spinal, C1-2, intradural, extramedullary meningeal sarcoma in which there were glial fibrillary acidic protein-immunoreactive components, but, importantly, no physical connection with neural tissue. On initial diagnostic imaging, neuroradiological features suggestive of a spinal meningioma were demonstrated in this 73-year-old man. He underwent a C1-2 laminectomy and removal of the posterior ring of the foramen magnum, and the lesion was excised. Histological and immunohistochemical testing showed a gliosarcoma. The clinical, radiological, and operative data are reviewed, as are the histopathological findings. To the authors' knowledge, this is the first case of a primary spinal intradural extramedullary gliosarcoma reported in the literature.
authors.affiliation: Institutes of Neurosurgery and Pathological Anatomy, University of Catania, Catania, Italy. giuseppebarbagal@hotmail.com
authors.forename: Giuseppe M V
authors.initials: GM
authors.lastname: Barbagallo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lanzafame
authors.forename: etti Giovanni F
authors.initials: eG
authors.lastname: Nicol
authors.forename: Nunzio
authors.initials: N
authors.lastname: Platania
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Albanese
mesh_terms: D000368:Aged; D002574:Cervical Vertebrae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D018316:Gliosarcoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery
chemical_list: D005904:Glial Fibrillary Acidic Protein