Molecular diversity of the HLA-A*19 group of alleles in North Indians: possible oriental influence.
The present study aims to determine the genetic diversity of the HLA-A19 allelic family in the North Indian and Japanese populations. The HLA-A*19 group of alleles occurred at similar frequencies in North Indians and Japanese as in Caucasians. All the known serological splits of HLA-A19 were observed among the North Indians, i.e. A*33 (15.6%), A*32 (8.6%), A*31 (3.5%), A*30 (3%), A*29 (1.2%) and A*74 (0.77%), while only A*30 (0.7%), A*31 (17.6%) and A*33 (11.7%) were observed in the Japanese. High resolution analysis indicated that the A*29, A*30, A*31 and A*32 alleles were represented by only single subtypes among the North Indians while the HLA-A*33 group comprised two alleles, A*3301 (4.3%) and A*3303 (43.7%). All 15 of the HLA-A*33 positive samples from the Tamil population of South India were found to be A*3303. One novel subtype of A*33, A*3306 was also observed in the North Indian sample. Conversely, only one subtype each of A*30, A*31 and A*33 was encountered in the Japanese population, of which A*3101 and A*3303 were the most frequent (58.5% and 39%, respectively, among the HLA-A*19 group of alleles). All other subtypes of A19 were not found in the Japanese in the present study. The study suggests a significant amount of genetic admixture in the North Indian gene pool from other racial groups, with profound oriental influence.
Jaini
R
R
All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Naruse
T
T
Kanga
U
U
Kikkawa
E
E
Kaur
G
G
Inoko
H
H
Mehra
N K
NK
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D014644:Genetic Variation; D015234:HLA-A Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007194:India; D007564:Japan; D044465:White People / Q000235:genetics*
D015234:HLA-A Antigens; C043205:HLA-A19 antigen