Formation of 2'-deoxy-2-nitroadenosines by reaction of 2'-deoxyadenosines with copper(II) nitrate/acetic anhydride.
Nitration of 9-substituted [ethyl, (Ac)2-2'-deoxyribosyl, (Ac)3-ribosyl] N6-acetyladenine derivatives with Cu(NO3)2.3H2O/Ac2O was examined. Nitration proceeded at the 2-position, although the yield was low. Removal of the acetyl groups gave 2'-deoxy-2-nitroadenosine derivatives.
Kaiya
Toyo
T
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Tanaka
Haruko
H
Kohda
Kohfuku
K
D000089:Acetic Anhydrides / Q000737:chemistry*; D000107:Acetylation; D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D003839:Deoxyadenosines / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009566:Nitrates / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000089:Acetic Anhydrides; D003839:Deoxyadenosines; D009566:Nitrates; C054123:N(6)-ribosyladenine; C031800:acetic anhydride; D003300:Copper; D000241:Adenosine