title: New chips for molecular biology and diagnostics.
abstract: The DNA chips are arrays of DNA probes immobilized on solid support for simultaneous identification of many target DNA sequences. DNA chips applied to diagnosis aims to detect genomic DNA or RNA after PCR amplification. This review provides an overview of DNA chip technology, focusing on diagnostic applications. A comparison between high density and low density microarrays is given showing that low density chips are more suitable for routine applications due to their simplicity, good reproducibility, easy data management and low cost.
authors.affiliation: Laboratory of Cellular Biochemistry, Facultés Universitaires Notre-Dame de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium. nathalie.zammatteo@fundp.ac.be
authors.forename: Nathalie
authors.initials: N
authors.lastname: Zammatteo
authors.forename: Sandrine
authors.initials: S
authors.lastname: Hamels
authors.forename: Françoise
authors.initials: F
authors.lastname: De Longueville
authors.forename: Isabelle
authors.initials: I
authors.lastname: Alexandre
authors.forename: Jean-luc
authors.initials: JL
authors.lastname: Gala
authors.forename: Francis
authors.initials: F
authors.lastname: Brasseur
authors.forename: José
authors.initials: J
authors.lastname: Remacle
mesh_terms: D001424:Bacterial Infections / Q000175:diagnosis*; D004352:Drug Resistance, Microbial; D004867:Equipment Design; D030342:Genetic Diseases, Inborn / Q000175:diagnosis*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000145:classification / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D014777:Virus Diseases / Q000175:diagnosis*