title: [Efficacy of 1% ropivacaine with and without hyaluronidase for peribulbar block].
abstract: OBJECTIVE
  To determine whether adding hyaluronidase to 1% ropivacaine without adrenalin enhances peribulbar anesthesia for cataract surgery with phacoemulsification.
  
  
  METHODS
  Prospective double-blind study of 100 patients (ASA I-III) scheduled for outpatient cataract surgery with peribulbar blockade. The patients were randomized to two groups of 50 to receive either 10 mL of 1% ropivacaine without adrenalin and without hyaluronidase (Group R) or 1% ropivacaine without adrenalin but with 10 U/mL of hyaluronidase (Group RH). We compared the presence of complete akinesia, of adequacy of surgical conditions, and of the need for reinjection. For statistical analysis we used the chi-squared test and a Student t-test for independent samples, with statistical significance at 5%.
  
  
  RESULTS
  A block adequate for surgery was obtained in 98% of the patients in Group RH and in 86.7% of the patients in Group R (p = 0.043). Reinjection was necessary for 28.6% of Group R patients and 8.9% of Group RH patients (p = 0.14). Complete akinesia was similar in the two groups.
  
  
  CONCLUSIONS
  The greater efficacy of a peribulbar block with the addition of 10 U/mL of hyaluronidase to 1% ropivacaine without adrenalin, in comparison to 1% ropivacaine alone, was demonstrated by a lower rate of reinjection and ocular mobility, even though no statistically significant difference in either ocular or palpebral akinesia was found.
authors.affiliation: Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital Universitario Dr. Peset, Av Gaspar Aguilar, 90 46018 Valencia. soliveres_jua@gva.es
authors.forename: J
authors.initials: J
authors.lastname: Soliveres Ripoll
authors.forename: C
authors.initials: C
authors.lastname: Solaz Roldán
authors.forename: J
authors.initials: J
authors.lastname: Viñoles Pérez
authors.forename: J
authors.initials: J
authors.lastname: Seller Losada
authors.forename: R
authors.initials: R
authors.lastname: Medel Pérez
authors.forename: M
authors.initials: M
authors.lastname: Barberá Alacreu
mesh_terms: D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage*; D008297:Male; D009407:Nerve Block / Q000379:methods*; D018918:Phacoemulsification; D011446:Prospective Studies; D000077212:Ropivacaine
chemical_list: D000577:Amides; D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D000077212:Ropivacaine; D006821:Hyaluronoglucosaminidase