Sucrose-stimulated release of FITC-dextran into the bile in the dynamics of its storage and elimination from the liver.
Stimulation of release of FITC-dextran endocytosed in the liver by an injection of hypertonic sucrose led to the appearance of a less pronounced and prolonged peak (with the maximum at min 15-25) at later terms after injection of the marker (30 days). Biliary release of FITC-dextran was 4-9-fold accelerated on days 1-14 in comparison with the constitutive release, and after 30 days it was accelerated 19-fold, which reflects high capacity of the long storage compartment to stimulated release of FITC-dextran into the bile.
Pupyshev
A B
AB
Central Research Laboratory, Novosibirsk State Medical Academy. apupyshev@mail.ru
Maiborodina
V I
VI
D000818:Animals; D001646:Bile / Q000378:metabolism*; D003911:Dextrans / Q000378:metabolism*; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000494:pharmacology*
D003911:Dextrans; C015219:fluorescein isothiocyanate dextran; D013395:Sucrose; D016650:Fluorescein-5-isothiocyanate