Kinetics of venom and antivenom serum and clinical parameters and treatment efficacy in Bothrops alternatus envenomed dogs.
Dogs envenomed with non-lethal doses of Bothrops alternatus venom received standard antivenom therapy, im injections of flunixin meglumine, or topical treatmentwith aqueous Curcuma longa plant extract. Biodistribution of the venom and antivenom were determined by ELISA. There was no significant difference in the efficacy of antivenom and plant extract on local effects; flunixin treatment had lower efficacy. Distribution of the venom was similar with all 3 treatments. Serum levels of the antivenom reached maximum 2-4 h after administration and were not detected after the 5th d.
Jacome
Do
D
Federal University of Minas Gerais, School of Veterinary Medicine, Department of Clinics, POB 567, CEP:30 1 23-970, Belo Horizonte, MG, Brazil.
Melo
M M
MM
Santos
M M B
MM
Heneine
L G D
LG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000997:Antivenins / Q000097:blood / Q000627:therapeutic use*; D017837:Bothrops; D003002:Clonixin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003435:Crotalid Venoms / Q000097:blood* / Q000493:pharmacokinetics / Q000633:toxicity; D030024:Curcuma; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000997:Antivenins; D003435:Crotalid Venoms; D028321:Plant Preparations; C014558:flunixin meglumine; D003002:Clonixin