The formation of colonic digestible films of amylose and ethylcellulose from aqueous dispersions at temperatures below 37 degrees C.
The film forming properties of a commercial aqueous ethylcellulose dispersion (Surelease) mixed with a range of ratios of an amylose/butanol complex in the presence of a range of concentrations of a plasticiser has been studied by measuring the minimum film forming temperature (MFFT). Contrary to what was to be anticipated from the literature, it was found that an additional 4% of the plasticiser (dibutyl sebacate), normally present in the standard formulation of the ethyl cellulose dispersion, was sufficient to lower the MFFT to allow the formation of films at 35 degrees C. This was confirmed by assessment of the glass transition temperature of free films prepared by casting and drying at 35 degrees C by the application of dynamic mechanical analysis. This technique also demonstrated that the ethylycellulose and the amylose were not miscible. The ability of faecal slurry to digest the films formed at low temperatures was confirmed by the use of a batch fermenter. The extent of digestion was directly related to the amylose content of the films, ensuring the potential to provide films, which could function as colon specific coatings.
Leong
C W
CW
School of Pharmacy, University of London, London, UK.
Newton
J M
JM
Basit
A W
AW
Podczeck
F
F
Cummings
J H
JH
Ring
S G
SG
D000688:Amylose / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D001831:Body Temperature; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000493:pharmacokinetics; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006358:Hot Temperature; D014867:Water / Q000737:chemistry
D014867:Water; C013517:ethyl cellulose; D002482:Cellulose; D000688:Amylose