[Cutaneous symptoms revealing a monoblastic leukemia].
Leukemia cutis (LC) are not rare in acute myeloid leukaemia (AML) in children but exceptionally reveal it. Most authors think that they have poor prognosis.


METHODS
We report the case of an infant with isolated cutaneous involvement at the time of diagnosis of leukaemia. Bone marrow aspiration showed AML M5. The child was treated by LAME 91 protocol, arm "infant under one year of age". Complete remission, both in bone marrow and skin, was obtained after induction course. Then the patient received consolidation course and megatherapy followed by autologous bone marrow transplantation. Skin relapse occurred early. The complete remission no. 2 was not obtained by second line treatment: new LC appeared when PMN count increased more than 10(9)/l. Then, the child was treated with oral VP16 but disease progressed with more and more LC, followed by bone marrow relapse. Child's death occurred about one year after diagnosis.
Dalle
J H
JH
Clinique de pédiatrie, unité protégée A, Hôpital Jeanne-de-Flandre, CHRU de Lille, 59037 Lille, France. jhdalle@wanadoo.fr
Mortier
L
L
Roumier
C
C
Laï
J L
JL
Catteau
B
B
Delaporte
E
E
Nelken
B
B
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007948:Leukemia, Monocytic, Acute / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011379:Prognosis; D012008:Recurrence; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy