Sperm and oocyte donor selection and management: experience of a 10 year follow-up of more than 2100 candidates.
BACKGROUND
The main concerns for couples undergoing assisted reproduction treatment using donor gametes are the possibilities of acquiring infectious diseases and of transmitting genetic disorders to the progeny. They are also frequently concerned and interested in the cultural and psychological background of the donors. Our aim was to examine the current prevalence of genetic alterations and infectious diseases in our sperm and oocyte donor population, and to review our experience in the management of donors and candidates during the last 10 years.


RESULTS
Routine blood analyses, semen and vaginal cultures together with complete medical, psychological and genetic histories were examined retrospectively. Our results clearly show that the frequency of sexually transmitted diseases and genetic disorders is comparable with both the frequency present in the population requiring infertility treatments and the general population.


CONCLUSIONS
The screening procedure applied to all the candidates sufficiently minimizes any risk to the gamete receiver and the offspring.
Garrido
N
N
Instituto Valenciano de Infertilidad Valencia (IVI), Fundación IVI para el Estudio de la Reproducción (FIVIER), Valencia University School of Medicine, Valencia, Spain. nicolas.garrido@ivi.es
Zuzuarregui
J L
JL
Meseguer
M
M
Simón
C
C
Remohí
J
J
Pellicer
A
A
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001419:Bacteria / Q000302:isolation & purification; D002176:Candida albicans / Q000302:isolation & purification; D005260:Female; D030342:Genetic Diseases, Inborn / Q000453:epidemiology; D006679:HIV Seropositivity / Q000453:epidemiology; D016174:Hepacivirus / Q000276:immunology; D006801:Humans; D007239:Infections / Q000453:epidemiology; D007621:Karyotyping; D008297:Male; D018587:Oocyte Donation; D012189:Retrospective Studies; D012661:Semen / Q000382:microbiology; D012749:Sexually Transmitted Diseases / Q000453:epidemiology; D018139:Simplexvirus / Q000276:immunology; D013094:Spermatozoa; D014019:Tissue Donors; D014621:Vagina / Q000382:microbiology
D000914:Antibodies, Viral