title: Successful treatment of basal cell carcinomas in a nevoid basal cell carcinoma syndrome with topical 5% imiquimod.
abstract: Gorlin-Goltz syndrome, also referred to as naevoid basal cell carcinoma syndrome (NBCCS), is an autosomal dominant skin disease with complete penetrance and inconstancy of the four major findings: multiple naevoid basal cell carcinomas (BCCs), pits on palms and soles, skeletal abnormalities (for example, jaw cysts), and ectopic calcification. The treatment of multiple BCCs is still a matter of debate. We report three cases of multiple BCCs in Gorlin-Goltz syndrome treated with topical 5% imiquimod cream, an immune response modifier. Patients were successfully cleared of BCCs after treatment for 6-8 weeks. Histologically no apparent signs of BCC-persistence could be detected and no recurrences were detected during the 12 month follow up period.
authors.affiliation: Department of Dermatology of the Charité, Humboldt University, Schumannstra e 20/21, 10117 Berlin, Germany. E.Stockfleth@web.de
authors.forename: Eggert
authors.initials: E
authors.lastname: Stockfleth
authors.forename: Claas
authors.initials: C
authors.lastname: Ulrich
authors.forename: Axel
authors.initials: A
authors.lastname: Hauschild
authors.forename: Stephan
authors.initials: S
authors.lastname: Lischner
authors.forename: Thomas
authors.initials: T
authors.lastname: Meyer
authors.forename: Enno
authors.initials: E
authors.lastname: Christophers
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage*; D001478:Basal Cell Nevus Syndrome / Q000188:drug therapy* / Q000473:pathology; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012494:Sampling Studies; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000077271:Imiquimod