title: Frequency of white matter lesions and silent lacunar infarcts.
abstract: White matter lesions and silent lacunar infarcts are related to and may result from cerebral small vessel disease. Reported frequencies of these lesions vary largely among studies. Differences in imaging techniques, rating scales, cut-off points in lesion severity grading and study populations contribute to the variation, in addition to differences in risk factor profiles across studies. In this paper, we will firstly discuss general methodological issues that may influence reported frequencies of white matter lesions and silent lacunar infarctions, and then review published data. We will focus on the results from population-based studies and only briefly comment on patient series of stroke and dementia.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: van Dijk
authors.forename: N D
authors.initials: ND
authors.lastname: Prins
authors.forename: S E
authors.initials: SE
authors.lastname: Vermeer
authors.forename: P J
authors.initials: PJ
authors.lastname: Koudstaal
authors.forename: M M B
authors.initials: MM
authors.lastname: Breteler
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D020520:Brain Infarction / Q000453:epidemiology* / Q000473:pathology*; D015161:Dementia, Multi-Infarct / Q000453:epidemiology* / Q000473:pathology*; D006801:Humans; D015994:Incidence; D015995:Prevalence