Early carbon dioxide challenge test may predict clinical response in panic disorder.
We examined whether responses to the carbon dioxide (CO(2)) challenge test were correlated with clinical response. Thirty-four panic disorder patients participated in a CO(2) test after 1 h, 2 weeks and 6 weeks of treatment with clonazepam (2 mg/day) or placebo. The clonazepam group had significantly fewer panic attacks in response to the CO(2) test and the test may predict clinical response.
Valença
Alexandre M
AM
Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro-RJ, Brazil. avalen@uol.com.br
Nardi
Antonio E
AE
Nascimento
Isabella
I
Zin
Walter A
WA
Lopes
Fabiana L
FL
Mezzasalma
Marco A
MA
Versiani
Marcio
M
D000328:Adult; D002245:Carbon Dioxide; D002998:Clonazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D011237:Predictive Value of Tests; D011379:Prognosis; D016896:Treatment Outcome
D002245:Carbon Dioxide; D002998:Clonazepam