The isolation of two new chromone derivatives from the New Zealand fungus Tolypocladium extinguens.
Two new chromone derivatives, 6-methoxymethyleugenin (1) and 2-hydroxymethyl-6-methoxymethyleugenin (2), and the previously reported 6-hydroxymethyleugenin (3) were isolated from the New Zealand fungus Tolypocladium extinguens. The structures of these compounds were elucidated on the basis of spectroscopic data. 6-Methoxymethyleugenin (1) showed moderate cytotoxicity against P388 leukemia cells.
Feng
Yunjiang
Y
Department of Chemistry and Department of Plant and Microbial Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Blunt
John W
JW
Cole
Anthony L J
AL
Munro
Murray H G
MH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004175:Diptera / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D007941:Leukemia P388; D008968:Molecular Conformation; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D017550:Spectroscopy, Fourier Transform Infrared; D014407:Tumor Cells, Cultured / Q000187:drug effects
C471760:2-hydroxymethyl-6-methoxymethyleugenin; C471759:6-hydroxymethyleugenin; C471758:6-methoxymethyleugenin; D000970:Antineoplastic Agents; D002867:Chromones