title: Plasma lidocaine concentrations following insertion of 2% lidocaine gel into the uterine cavity after uterine balloon thermal ablation.
abstract: BACKGROUND
  Uterine balloon thermal ablation is used to treat menorrhagia. We thought that intrauterine application of 2% lidocaine gel could reduce postoperative pain after this procedure. Before using this technique we wished to establish how much lidocaine is absorbed systemically from the uterine cavity after thermal ablation.
  
  
  METHODS
  Ten ASA I-II patients (age 38-50 yr) underwent uterine balloon thermal ablation under general anaesthesia. They each had 11 ml of 2% lidocaine gel (Instillagel(TM)) inserted into the uterine cavity at the end of the procedure. Blood samples were taken at 5, 15, 30 and 60 min after insertion and lidocaine concentrations were measured using high-performance liquid chromatography.
  
  
  RESULTS
  Mean (range) plasma lidocaine concentrations at 5, 15, 30 and 60 min were 40.3 (0-221.9), 66.3 (0-271.9), 64.9 (0-208) and 75 (0-212) ng ml(-1), respectively.
  
  
  CONCLUSIONS
  There was minimal systemic absorption of lidocaine from the uterus following uterine balloon thermal ablation. Measured concentrations were well below the toxic plasma concentration for lidocaine (8-10 micro g ml(-1)).
authors.affiliation: Department of Anaesthesia, North Devon District Hospital, Barnstaple EX31 4JB, UK. guy.rousseau@virgin.net
authors.forename: G F
authors.initials: GF
authors.lastname: Rousseau
authors.forename: M
authors.initials: M
authors.lastname: Oram
authors.forename: J
authors.initials: J
authors.lastname: Barrington
authors.forename: M
authors.initials: M
authors.lastname: Priston
authors.forename: M
authors.initials: M
authors.lastname: Swart
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D005782:Gels; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood*; D008595:Menorrhagia / Q000097:blood / Q000601:surgery; D008875:Middle Aged; D010149:Postoperative Pain / Q000097:blood / Q000517:prevention & control*; D014599:Uterus / Q000378:metabolism / Q000601:surgery*
chemical_list: D000779:Anesthetics, Local; D005782:Gels; D008012:Lidocaine