Could cognitive vulnerability identify high-risk subjects for schizophrenia?
This review puts into questions the possible role of cognitive vulnerability markers in prediction and prevention of schizophrenia. Until recently, none of the identified cognitive anomalies has been proved to be definitive. However, as new promising candidates are emerging (DS-CPT, CPT-IP, P suppression, Saccadic Eye Movements), the predictive value of these trait-type anomalies may be criticized regarding four issues, which are discussed: technical, metrological, theoretical, and clinical. As things stand, the existence of a cognitive vulnerability marker, which testify to a permanent pathological trait, does not constitute a sufficient factor to identify and treat subjects who are at risk for schizophrenia.
Sarfati
Yves
Y
University Department of Psychiatry, Versailles Hospital, France. ysarfati@ch-versailles.fr
Hardy-Baylé
Marie-Christine
MC
D003072:Cognition Disorders; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control