title: Evaluation of radiation carcinogenesis risk in vertebral hemangioma treated by radiotherapy.
abstract: The purpose of this study is to report carcinogenesis risk factor evaluation in vertebral hemangioma patients treated by radiotherapy. Between 1975 and 1995, 29 patients received 20-30 Gy total irradiation dose using conventional fractionation scheme. All the patients had measurements with thermoluminescent dosimeters (TLD 100 ), placed on multiple randophantom sites in vivo within the irradiated volume, to verify irradiation accuracy and calculate carcinogenesis risk factor. Twenty nine still-alive patients who had a minimum 6-year and maximum 26-year follow-up (median 14.34 years) have been evaluated by carcinogenic radiation risk factor on the basis of tissue weighting factors as defined by International Commission on Radiological Protection Publication 60. Reasonable pain relief has been obtained in all 29 patients. Calculated mean carcinogenesis risk factor is 0.6% for single irradiation portals and 0.9% for double irradiation portals in the whole group, whilst no secondary cancer has been detected. Radiotherapy is an effective treatment modality in relieving pain of vertebral hemangioma patients. Estimated secondary cancer risk factor for this benign neoplasm irradiation is not as high as can be feared.
authors.affiliation: Department of Radiation Oncology; GATA Military Medical School, Ankara, 6018 Turkey. muratbeyzadeoglu@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Beyzadeoglu
authors.forename: B
authors.initials: B
authors.lastname: Dirican
authors.forename: K
authors.initials: K
authors.lastname: Oysul
authors.forename: S
authors.initials: S
authors.lastname: Surenkok
authors.forename: Y
authors.initials: Y
authors.lastname: Pak
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006391:Hemangioma / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000517:prevention & control; D019047:Phantoms, Imaging; D011874:Radiometry; D012307:Risk Factors; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control / Q000532:radiotherapy*; D013696:Temperature; D013997:Time Factors; D014018:Tissue Distribution