NMR methods for characterizing microsecond to millisecond dynamics in recognition and catalysis.
During the past two years, significant advances have been made in the development of NMR methods for studying biomolecular dynamics on the microsecond to millisecond timescale. Applications of these methods to biologically relevant systems have provided compelling evidence that, in many cases, conformational dynamics on these timescales govern the rates of biomolecular recognition and catalysis.
Akke
Mikael
M
Department of Biophysical Chemistry, Lund University, PO Box 124, SE-221 00 Lund, Sweden. mikael.akke@bpc.lu.se
D000495:Allosteric Site; D002384:Catalysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D013997:Time Factors