title: Maximum entropy modeling for mining patient medication status from free text.
abstract: Using a classification scheme of patient medication status we sought to recognize and categorize medications mentioned in the unrestricted text of clinical documents generated in clinical practice. The categories refer to the patient's status with respect to the medication such as discontinuation, start or initiation, and continuation of a given medication. This categorization is performed with a machine learning technique, Maximum Entropy (ME), that is well suited to incorporating heterogeneous sources of information necessary for classifying patient's medication status. We use hand labeled training data to generate ME models and test 5 different training feature sets. Our results show that the most optimal feature set includes a combination of the following: two words preceding and following the mention of the drug, the subject of the sentence in which the drug mention occurs, the 2 words following the subject, and a binary feature vector of lexicalized semantic cues indicative of medication status or its change. The average predictive power of a model trained on these features is approximately 89%.
authors.affiliation: Division of Medical informatics Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Serguei V
authors.initials: SV
authors.lastname: Pakhomov
authors.forename: Alexander
authors.initials: A
authors.lastname: Ruggieri
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Chute
mesh_terms: D001185:Artificial Intelligence; D004358:Drug Therapy / Q000145:classification*; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods*; D016347:Medical Records Systems, Computerized; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000145:classification; D010865:Pilot Projects; D011237:Predictive Value of Tests
chemical_list: D004364:Pharmaceutical Preparations