title: Gas chromatography-high-resolution mass spectrometry based method for the simultaneous determination of nine organotin compounds in water, sediment and tissue.
abstract: A GC-HRMS based method for the accurate and sensitive determination of nine organotin compounds, tetrabutyltin (TeBT), tributyltin (TBT), dibutyltin (DBT), monobutyltin (MBT), triphenyltin (TPhT), diphenyltin (DPhT), monophenyltin (MPhT), tricyclohexyltin (TCyT), and dicyclohexyltin (DCyT) in sediment, tissue and water samples is presented and discussed. Mass spectral features of these analytes via both low resolution quadrupole and high resolution magnetic sector, GC-HRMS conditions under selective ion monitoring mode and QA/QC criteria for the positive identification of analyte are all provided. Linearity of response and minimal detectable limits are illustrated for each of the nine compounds monitored and the estimates of method limits-of-detection were 7-29 ppt for water and 0.35-1.45 ppb for tissue or sediments. Sample preparation considerations and precision are discussed for spiked water and sediment samples, whereas method accuracy was established by analysing a certified reference material (CRM) mussel sample and comparing our results to the assigned values. Good agreement was found between our results and assigned or indicative values for MBT, DBT, TBT, DPhT and TPhT (cyclohexyl-tins were not present in the CRM).
authors.affiliation: Contaminants Science Section, Institute of Ocean Sciences, Department of Fisheries and Oceans Canada, 9860 W Saanich Rd., Sidney, BC, Canada V8L 4B2. ikonomoum@dfo-mpo.gc.ca
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ikonomou
authors.forename: Marc P
authors.initials: MP
authors.lastname: Fernandez
authors.forename: Tim
authors.initials: T
authors.lastname: He
authors.forename: Donna
authors.initials: D
authors.lastname: Cullon
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D019015:Geologic Sediments / Q000737:chemistry*; D009947:Organotin Compounds / Q000032:analysis*; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D009947:Organotin Compounds; D014874:Water Pollutants, Chemical