title: Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits.
abstract: OBJECTIVE
  To examine the relationship between plasma cytokine levels and cardiac and hemodynamic function.
  
  
  METHODS
  Measurement of cytokines and the systolic (left ventricular dimensions, heart rate, and cardiac output) and diastolic (early and late transmitral peak flow velocity: E and A-waves and their ratio) functions of the left ventricle (assessed by echocardiography) in rabbits.
  
  
  METHODS
  Laboratory and echocardiographic analyses were performed at baseline and at 1, 3, 6, 12, and 24 h after acute necrotizing pancreatitis induction (Group ANP), in rabbits after somatostatin pretreatment (Group S-ANP) and in sham-operated controls (Group C).
  
  
  RESULTS
  Left ventricular dilatation occurred at 6 h and cardiac output was increased 3 h after induction of acute necrotizing pancreatitis. Somatostatin pretreatment mitigated the left ventricular enlargement and filling abnormalities. Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction, but to a lesser extent in Group S-ANP, while somatostatin prevented TNFalpha release (IL-6: Group ANP: 0, 0, 518+/-139, 956+/-125, 373+/-48, and 122+/-37 pg/ml; Group S-ANP: 0, 0, 191+/-68, 261+/-49, 23+/-13, and 0 pg/ml; TNFalpha: Group ANP: 88+/-42, 371+/-40, 2963+/-291, 276+/-30, 197+/-106, and 23+/-14 U/l; Group S-ANP: 91+/-34, 41+/-25, 68+/-42, 25+/-9, 0, and 0 U/ml). The increase in plasma level of IL-6 correlated significantly with left ventricular end-diastolic diameter and volume, cardiac output, and diastolic dysfunction.
  
  
  CONCLUSIONS
  Plasma levels of IL-6, but not TNFalpha correlate with cardiac output and left ventricular filling characteristics in acute pancreatitis. Somatostatin pretreatment improves the cardiac and hemodynamic changes, probably through the decrease in cytokine release.
authors.affiliation: 2nd Dept of Int Medicine and Cardiological Center, University of Szeged, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Jambrik
authors.forename: Mariann
authors.initials: M
authors.lastname: Gyöngyösi
authors.forename: Péter
authors.initials: P
authors.lastname: Hegyi
authors.forename: László
authors.initials: L
authors.lastname: Czakó
authors.forename: Tamás
authors.initials: T
authors.lastname: Takács
authors.forename: András
authors.initials: A
authors.lastname: Farkas
authors.forename: Yvette
authors.initials: Y
authors.lastname: Mándy
authors.forename: Csaba
authors.initials: C
authors.lastname: Góg
authors.forename: Dietmar
authors.initials: D
authors.lastname: Glogar
authors.forename: Miklós
authors.initials: M
authors.lastname: Csanády
mesh_terms: D000818:Animals; D004452:Echocardiography; D006439:Hemodynamics / Q000502:physiology*; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011817:Rabbits; D012044:Regression Analysis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha