Protective effect of anisodamine on respiratory function after severe brain injury.
OBJECTIVE
To study the clinical therapeutic effect of anisodamine on respiratory function after severe brain injury.


METHODS
Ninety patients with respiratory dysfunction following severe brain injury were divided into two groups: a treatment group (n = 45, treated with routine therapy plus anisodamine) and a control group (n = 45, treated with routine therapy only). The pulmonary ventilation function and oxygenation function were compared between the two groups.


RESULTS
In the treatment group, 12 hours after treatment the respiratory rate reduced, the partial pressure of carbon dioxide (PCO(2)), the partial pressure of oxygen in arterial blood (PaO(2)) and oxygenation exponent increased, the dead space ventilation dose and the pulmonary alveolus-partial pressure of arterial oxygen difference decreased, and the ventilation function of the respiratory tract and pulmonary oxygenation function improved. There was a significant difference between the two groups (P < 0.01). No side-effect was found except a slight increase of intracranial pressure and heart rate.


CONCLUSIONS
Anisodamine can improve pulmonary ventilation function and oxygenation function and decrease the incidence of hypoxemia markedly. It is effective in treating respiratory dysfunction after severe brain injury.
Huang
Qiang
Q
Neurosurgery Department, People's Hospital of Quzhou City, Quzhou 324000, China.
Dai
Weimin
W
Jie
Yuanqing
Y
Yu
Guofeng
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D011322:Primary Prevention / Q000379:methods; D011336:Probability; D011659:Pulmonary Gas Exchange; D012016:Reference Values; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D012991:Solanaceous Alkaloids / Q000008:administration & dosage*; D015996:Survival Rate; D016896:Treatment Outcome
D012991:Solanaceous Alkaloids; C003922:anisodamine