The role of matrix metalloproteinases in rheumatoid tendon disease.
In rheumatoid arthritis (RA) invasive tenosynovitis is associated with an increase in tendon rupture, although little is known about the mechanisms involved. We obtained specimens of noninvasive encapsulating tenosynovium, invasive tenosynovium, and wrist joint synovium from 28 rheumatoid patients. In vitro production of the matrix metalloproteinase (MMP) enzymes, MMP-8 and -9, and total collagenase activity were measured. Invasive tenosynovium produced highest levels of the collagenase MMP-8 and displayed significantly greater ability to degrade collagen type I than encapsulating tenosynovium. Levels of the gelatinase enzyme MMP-9 were similar in all groups. These results show that invasive tenosynovium is more destructive than encapsulating tenosynovium at a molecular level, providing an explanation for the increased tendon rupture associated with invasive tenosynovitis in RA.
Jain
Abhilash
A
Department of Musculoskeletal Surgery and the Kennedy Institute of Rheumatology, Imperial College School of Medicine, The Charing Cross Hospital Campus, London, UK.
Brennan
Fionula
F
Troeberg
Linda
L
Nanchahal
Jagdeep
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism*; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D008875:Middle Aged; D012421:Rupture / Q000201:enzymology / Q000209:etiology; D013583:Synovial Membrane / Q000201:enzymology; D013710:Tendons / Q000201:enzymology*; D014955:Wrist Joint / Q000201:enzymology
D024042:Collagen Type I; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9