title: Lipoprotein lipase as a therapeutic target for dyslipidemia.
abstract: The importance of lipoprotein lipase (LPL) in the regulation of overall lipid metabolism in humans and other animals is well documented. The major goal of this review is to identify and justify features that make LPL an important drug target for lipid management in particular for triglyceride lowering and HDL elevation, and propose strategies to modulate LPL activity.
authors.affiliation: Reddy US Therapeutics, 3065 Northwoods Circle, Norcross, GA 30071, USA. ram@reddyus.com
authors.forename: Sivaram
authors.initials: S
authors.lastname: Pillarisetti
authors.forename: Uday
authors.initials: U
authors.lastname: Saxena
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000201:enzymology*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*
chemical_list: D000960:Hypolipidemic Agents; D008071:Lipoprotein Lipase