title: LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis.
abstract: The Liver X Receptors (LXR alpha, NR1H3; LXR beta, NR1H2) encode highly homologous transcription factors that are members of the nuclear receptor superfamily of proteins. Both LXR alpha and LXR beta form heterodimers with the obligate partner 9-cis retinoic acid receptor alpha (RXR alpha; NR2B1). LXR/RXR heterodimers function as sensors for cellular oxysterols and, when activated by these agonists, increase the expression of genes that control sterol and fatty acid metabolism/homeostasis. These conclusions are based on studies that: (i) identified oxysterols as the natural ligands for both LXR alpha and LXR beta; (ii) identified target genes that are activated by LXR/RXR; (iii) generated mice that were deficient in LXR alpha, LXR beta or both LXR alpha and LXR beta; (iv) identified synthetic LXR ligands that were extremely potent in vivo; and (v) demonstrated significant alterations in cholesterol and fatty acid homeostasis in animals in which LXR had been either activated or deleted. These findings suggest that synthetic LXR ligands may prove useful in the treatment of certain dyslipidemias. In this review, we summarize the current status of this rapidly moving area with a special emphasis on the potential for pharmacological intervention.
authors.affiliation: Departments of Biological Chemistry and Medicine, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA. pedwards@mednet.ucla.edu
authors.forename: Peter A
authors.initials: PA
authors.lastname: Edwards
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Kennedy
authors.forename: Puiying A
authors.initials: PA
authors.lastname: Mak
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation / Q000235:genetics*; D006706:Homeostasis / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000235:genetics*; D000071518:Liver X Receptors; D051379:Mice; D018345:Mice, Knockout; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D008055:Lipids; D000071518:Liver X Receptors; C000605210:NR1H2 protein, human; C000605213:NR1H3 protein, human; C000605211:Nr1h2 protein, mouse; C000605214:Nr1h3 protein, mouse; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear