title: [Effects of midodrine on symptomatic hypotension during hemodialysis].
abstract: BACKGROUND
  Hypotension occurs in 20% of hemodialysis procedures.
  
  
  OBJECTIVE
  To study the effects of midodrine on hypotension during hemodialysis.
  
  
  METHODS
  Ten patients on chronic hemodialysis and with a history of hypotension during the procedure, were studied. They received midodrine 10 mg per os or placebo during 5 dialytic procedures each, in a double blind cross over design.
  
  
  RESULTS
  Blood pressure levels prior to dialysis were similar during the midodrine or placebo administration periods. During dialysis, systolic blood pressure fell 19.3 +/- 28 mmHg with midodrine and 23.4 +/- 28 mmHg with placebo. Diastolic blood pressure fell 7.3 +/- 11.5 mmHg with midodrine and 11.1 +/- 12 mmHg with placebo. The reduction in median arterial pressure was also less pronounced with midodrine.
  
  
  CONCLUSIONS
  Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension.
authors.affiliation: Unidad de Atención Nefrológica Continua, Sección de Nefrología, Departamento de Medicina, Hospital Clínico Universidad de Chile. acotera@manquehue.net
authors.forename: Alejandro
authors.initials: A
authors.lastname: Cotera
authors.forename: Miriam
authors.initials: M
authors.lastname: Alvo
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Sanhueza
authors.forename: Leticia
authors.initials: L
authors.lastname: Elgueta
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Gormaz
authors.forename: Carlos
authors.initials: C
authors.lastname: Ibáñez
authors.forename: Cristián
authors.initials: C
authors.lastname: Cuadra
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000494:pharmacology*; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D008879:Midodrine