Clinical experience with adenovirus in cancer therapy.
Gene therapy is emerging as a novel treatment for cancer. Preclinical data utilizing adenovirus vectors have been promising and several clinical trials employing this employing this vector are underway. Data from many phase I trials have established the safety of adenovirus vectors, but have not as yet demonstrated significant therapeutic benefit. In order to refine this approach, continuing efforts are being made to improve antitumor potency, efficiency of gene delivery and accuracy of vector targeting. It is anticipated that adenovirus-mediated gene therapy will be integrated with existing treatment modalities, including surgery, chemotherapy and radiotherapy, to facilitate improvement in cancer treatments in the future.
Palmer
Daniel H
DH
CR UK Institute for Cancer Studies, The Medical School, University of Birmingham, Edgbaston, UK. danp@cancer.bham.ac.uk
Mautner
Vivien
V
Kerr
David J
DJ
D000256:Adenoviridae / Q000235:genetics*; D002986:Clinical Trials as Topic; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000628:therapy*