title: Influence of diet complexity on intestinal adaptation following massive small bowel resection in a preclinical model.
abstract: OBJECTIVE
  To investigate the effect of dietary complexity on intestinal adaptation using a preclinical model.
  
  
  METHODS
  Four-week-old piglets underwent a 75% proximal small bowel resection or transection operation (control). Post-operatively, animals received either pig chow (n = 15), polymeric formula (n = 9), polymeric formula plus fiber (n = 6), or elemental formula (n = 7).
  
  
  RESULTS
  The weight gain of all groups was reduced compared with controls that were fed the same diet. Animals that had a resection, which were fed elemental formula, had significantly reduced weight gain compared with the other groups (4.7 4.2 vs 30.7 7.1 kg chow and 11.5 1.3 kg polymeric formula). Villus height was increased in the jejunum, ileum and terminal ileum of resected animals compared with controls in animals fed with pig chow, polymeric formula and elemental formula. The animals that had a resection had a significant reduction in the transepithelial conductance (10.4 5.5 vs 25.4 6.5 mS/cm2) and 51Chromium-EDTA flux (2.8 1.9 vs 4.8 4.9 microL/h per cm2) compared with the controls.
  
  
  CONCLUSIONS
  A complex diet was found to be superior to an elemental diet in terms of the morphological and functional features of adaptation following massive small bowel resection.
authors.affiliation: Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville, Victoria, Australia. bines@cryptic.rch.unimelb.edu.au
authors.forename: Julie E
authors.initials: JE
authors.lastname: Bines
authors.forename: Russell G
authors.initials: RG
authors.lastname: Taylor
authors.forename: Frances
authors.initials: F
authors.lastname: Justice
authors.forename: Monique C J
authors.initials: MC
authors.lastname: Paris
authors.forename: Magdy
authors.initials: M
authors.lastname: Sourial
authors.forename: Eva
authors.initials: E
authors.lastname: Nagy
authors.forename: Sarah
authors.initials: S
authors.lastname: Emselle
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Catto-Smith
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fuller
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D016022:Case-Control Studies; D005260:Female; D005526:Food, Formulated; D007082:Ileum / Q000378:metabolism / Q000601:surgery; D007413:Intestinal Mucosa / Q000502:physiology*; D007421:Intestine, Small / Q000378:metabolism / Q000601:surgery*; D007583:Jejunum / Q000378:metabolism; D013552:Swine; D015430:Weight Gain