title: Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical "footprinting".
abstract: For many years, hydroxyl radical footprinting has been an insightful probe of the solvent accessibility of local regions of nucleic acid structure. Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively.
authors.affiliation: Department of Biochemistry, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. brenowit@aecom.yu.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Brenowitz
authors.forename: Mark R
authors.initials: MR
authors.lastname: Chance
authors.forename: Gauri
authors.initials: G
authors.lastname: Dhavan
authors.forename: Keiji
authors.initials: K
authors.lastname: Takamoto
mesh_terms: D004247:DNA / Q000737:chemistry*; D018983:DNA Footprinting / Q000379:methods*; D017665:Hydroxyl Radical; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D017665:Hydroxyl Radical; D012313:RNA; D004247:DNA