Signals regulating muscle formation in the limb during embryonic development.
Classically, somites have been the preparation of choice for the study of muscle development, while the limb bud is the preferred model of axis formation. Nevertheless, the limb bud offers some experimental advantages for muscle studies. This review describes the successive events involved in limb muscle formation during embryonic development, the properties of the key marker molecules and resumes our current knowledge of the signalling pathways involved.
Duprez
Delphine
D
Biologie du Développement, CNRS UMR 7622, Université P. et M. Curie, Paris, France. duprez@ccr.jussieu.fr
D000818:Animals; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002642:Chick Embryo; D003238:Connective Tissue / Q000196:embryology; D004627:Embryonic Induction / Q000502:physiology*; D005121:Extremities / Q000196:embryology*; D005346:Fibroblast Growth Factors / Q000502:physiology; D053823:Hedgehog Proteins; D024510:Muscle Development / Q000502:physiology*; D032446:Myoblasts / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D005346:Fibroblast Growth Factors