Recurrence of hemolytic uremic syndrome after live related renal transplantation associated with subsequent de novo disease in the donor.
There is a significant risk of disease recurrence in patients with nondiarrheal (D-) hemolytic uremic syndrome (HUS) undergoing renal transplantation. Recent studies have found that approximately 20% of sporadic cases of HUS have mutations in the gene for the complement regulatory protein factor H. The authors report on 2 families, in each of which a family member initially presented with sporadic HUS and subsequently received a live-related renal transplant, one from a sibling and the other from the father. Subsequently, both recipients suffered recurrent HUS in the allograft, and both donors had HUS within a year of the transplant. Neither family has a factor H mutation. This report underlines the risk of disease recurrence in recipients associated with live-related renal transplantation in HUS and also suggests that the donors may be at risk.
Donne
Rosemary L
RL
School of Clinical Medical Sciences, University of Newcastle upon Tyne, England.
Abbs
Ian
I
Barany
Peter
P
Elinder
Carl-Gustaf
CG
Little
Mark
M
Conlon
Peter
P
Goodship
Timothy H J
TH
D000328:Adult; D002675:Child, Preschool; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D019520:Living Donors; D008297:Male; D009679:Nuclear Family; D012008:Recurrence; D014184:Transplantation, Homologous / Q000379:methods