title: Exploratory analysis of the spatio-temporal deformation of the myocardium during systole from tagged MRI.
abstract: Myocardial contractile function is, with perfusion, one of the main affected factors in ischemic heart diseases. In this paper, we propose an original framework based on functional data analysis for the quantitative study of spatio-temporal parameters related to the myocardial contraction mechanics. The mechanical strains in the left-ventricular (LV) myocardium are computed from tagged magnetic resonance imaging cardiac sequences. A statistical functional model of the normal contractile function of the LV is build from the study of eight examinations on healthy subjects. We show that it is possible to detect abnormal strain patterns comparatively to this model, by generating distance maps at rest and under pharmacological stress. We demonstrate the consistency of the results for the circumferential deformation parameter on healthy and pathological data sets.
authors.affiliation: CREATIS, French National Center for Scientific Research Unit #5515, INSA Bâtiment Blaise Pascal, 69621 Villeurbanne Cedex, France. patrick.clarysse@creatis.insa-lyon.fr
authors.forename: Patrick
authors.initials: P
authors.lastname: Clarysse
authors.forename: Meimei
authors.initials: M
authors.lastname: Han
authors.forename: Pierre
authors.initials: P
authors.lastname: Croisille
authors.forename: Isabelle E
authors.initials: IE
authors.lastname: Magnin
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D004280:Dobutamine; D025401:Echocardiography, Stress; D005080:Exercise Test; D006352:Heart Ventricles / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium; D025341:Principal Component Analysis; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013599:Systole
chemical_list: D004280:Dobutamine