Population pharmacokinetics of digoxin in pediatric patients.
Digoxin pharmacokinetics were studied in a pediatric population with an age range of 6 days to 1 year using the population pharmacokinetic approach. Digoxin data were analyzed by mixed-effects modeling according to a one-compartment steady-state pharmacokinetic model using NONMEM software. The final model selected for the population prediction of digoxin clearance in pediatric patients was as follows: [equation: see text] Individual empirical Bayesian estimates were generated on the basis of the population estimates and were used to correlate the optimum dose of digoxin and patient age according to the following equation: [equation: see text] This equation and its derived nomogram may be used for the initial dosing of digoxin in children aged between 0 and 1 year. The use of this nomogram in routine monitoring requires further pharmacokinetic and clinical validation.
Martín-Suárez
A
A
Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Spain.
Falcao
A C
AC
Outeda
M
M
Hernández
F J
FJ
González
M C
MC
Quero
M
M
Arranz
I
I
Lanao
J M
JM
D000465:Algorithms; D001499:Bayes Theorem; D002316:Cardiotonic Agents / Q000493:pharmacokinetics*; D004077:Digoxin / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008954:Models, Biological; D011153:Population; D012189:Retrospective Studies; D012984:Software
D002316:Cardiotonic Agents; D004077:Digoxin