title: Secretin and sleep in children with autism.
abstract: The objectives of this pilot study were 1) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism, and 2) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism. Participants were a subset of subjects from two double blind, placebo-control, multi-center clinical trials. One trial, the UC Irvine study, assessed the effects of porcine secretin vs. saline infusions on children's behavior, language and IQ. The UC Davis trial assessed the effects of synthetic human secretin vs. saline infusions on behavior, language and gastrointestinal function. The sleep study enrolled some of the children from each of the two trials to observe possible secretin effects on sleep. To examine sleep, the UC Irvine trial used the Children's Sleep Habits Questionnaire and daily sleep diaries, whereas the UC Davis study used home-recorded time-lapse videosomnography. Because of the small sample size, the results from both trials are preliminary. They suggest that secretin, porcine or synthetic, does not improve sleep-wake state organization dramatically.
authors.affiliation: University of California, Davis 95616, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Honomichl
authors.forename: Beth L
authors.initials: BL
authors.lastname: Goodlin-Jones
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Burnham
authors.forename: Robin L
authors.initials: RL
authors.lastname: Hansen
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Anders
mesh_terms: D001321:Autistic Disorder / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D015999:Multivariate Analysis; D010865:Pilot Projects; D017286:Polysomnography / Q000379:methods; D012633:Secretin / Q000627:therapeutic use*; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005765:Gastrointestinal Agents; D012633:Secretin