Expression of c-Fos-like immunoreactive neurons in the supratrigeminal region in the rat following noxious stimulation of the orofacial tissues.
This study was conducted to investigate immunohistochemically the expression of c-Fos in neurons around the trigeminal motor nucleus following application of mechanical force to a tooth, a mechanical pinch to the tongue, and paraformaldehyde injection into the periodontal ligament and masseter muscle. Following the application of all of these stimuli except pinching the tongue, a small number of c-Fos-like immunoreactive (Fos-LI) neurons were found in the ipsilateral supratrigeminal region. c-Fos expression was also detected in numerous neurons in the superficial laminae of the subnucleus caudalis in all experimental animals. Induction of c-Fos in the subnucleus caudalis and the supratrigeminal region indicates that Fos-LI neurons in the supratrigeminal region are involved in the processing of intraoral nociceptive signals.
Watanabe
Mineo
M
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Japan. mineo@hiroshima-u.ac.jp
Tanaka
Eiji
E
Nishi
Mika
M
Iwabe
Tatsunori
T
Hattori
Yukiko
Y
Suemune
Setsuko
S
Tanne
Kazuo
K
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000009:adverse effects; D005557:Formaldehyde / Q000009:adverse effects; D007839:Functional Laterality; D007150:Immunohistochemistry; D008297:Male; D008406:Masseter Muscle / Q000166:cytology / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010513:Periodontal Ligament / Q000187:drug effects / Q000502:physiology; D010812:Physical Stimulation; D011108:Polymers / Q000009:adverse effects; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D014059:Tongue / Q000166:cytology / Q000187:drug effects; D014070:Tooth; D014278:Trigeminal Nuclei / Q000378:metabolism*
D000891:Anti-Infective Agents, Local; D011108:Polymers; D016760:Proto-Oncogene Proteins c-fos; D005557:Formaldehyde; C003043:paraform