Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alpha-tocopherol dispersions.
The hypoglycemic effect of orally given insulin was studied on rabbits, using different bile salts as absorption promoters, in two different carriers to form an artificial chyloform system ready to be absorbed by intestinal mucosa. The rank order of enhancement by bile salts in the presence of 1% ethanol was deoxycholate>cholate>glycocholate>glycodeoxycholate>taurodeoxycholate>no bile salts. The dose response studies with increased insulin loaded in the chyle showed a greater corresponding hypoglycemic effect with the system of cholate-palmitic-alpha-tocopherol dispersions than the cholate-palmitic acid dispersions. A more effective hypoglycemic effect was achieved using lower doses of the deoxycholate-palmitate-tocopherol-chyle dispersions.
Mesiha
Mounir S
MS
Division of Pharmaceutics and Industrial Pharmacy, Arnold and Marie Schwartz College of Pharmacy, Long Island University, 75 DeKalb Avenue, Brooklyn, NY 11201, USA. mmesiha@liu.edu
Ponnapula
Sulochana
S
Plakogiannis
Fotios
F
D000284:Administration, Oral; D000818:Animals; D001647:Bile Acids and Salts / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001786:Blood Glucose / Q000378:metabolism; D002214:Capsules; D002913:Chyle / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008297:Male; D019308:Palmitic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000493:pharmacokinetics*
D001647:Bile Acids and Salts; D001786:Blood Glucose; D002214:Capsules; D007004:Hypoglycemic Agents; D007328:Insulin; D019308:Palmitic Acid; D024502:alpha-Tocopherol