title: [Experience of biologically active supplements to food containing indoles and isothiocyanates in patients with chronic viral hepatitis].
abstract: We have studied the effect of dietary supplement "ExPress" on clinical and biochemical parameters and on the activity of detoxification enzymes of liver in patients with chronic viral hepatitis B and C. 24 patients (19 females and 5 males aged 16-39 years) were enrolled in the study. Patients in case group received dietary supplement "ExPress" in addition to basic treatment. Average indices of total bilirubin in cases after treatment were 26.98 +/- 2.85 mmol/l, while in controls--34.31 +/- 5.72 mmol/l (p > 0.05). Average indices of alanin-aminotransferase and aspartate-aminotransferase were 78.75 +/- 11.25 and 160.75 +/- 23.67 units while in controls--208.5 +/- 56.4 and 330.25 +/- 65.14 units respectively (p < 0.05). In case group we observed full normalization of thymol test--from 9.99 +/- 1.51 to 4.03 +/- 0.73 units (p = 0.001), while in controls--from 7.9 +/- 1.56 only to 5.2 +/- 1.15 units (p = 0.194). Contents of non-metabolized antipyrine in cases decreased from 9.76 +/- 1.2% (p = 0.0002) whilst in controls--from 9.38 +/- 1.28% only to 3.93 +/- 1.18% (p = 0.01). Results of the study show that dietary supplement "ExPress" induces the activity of detoxification enzymes of liver and increases the efficiency of basic treatment.
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Gichev
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Gichev
authors.forename: O R
authors.initials: OR
authors.lastname: Grek
authors.forename: N P
authors.initials: NP
authors.lastname: Tolokonskaia
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Chernousova
authors.forename: T G
authors.initials: TG
authors.lastname: Tomilenko
authors.forename: K
authors.initials: K
authors.lastname: Makkosland
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D016022:Case-Control Studies; D019587:Dietary Supplements; D000077553:Edaravone; D005260:Female; D019694:Hepatitis B, Chronic / Q000178:diet therapy* / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000178:diet therapy* / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D007211:Indoles / Q000627:therapeutic use*; D017879:Isothiocyanates / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D008297:Male
chemical_list: D007211:Indoles; D017879:Isothiocyanates; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin; D000077553:Edaravone; D000983:Antipyrine