[The immunometaboic effects of benfotiamine and riboxine on hemolytic anemia].
Single (80 mg/kg) or multiply repeated (30 mg/kg) intramuscular injections of phenylhydrazine decrease the functional activity of mononuclear blood cells and the reduces immunological reactivity of the organism. Benfotiamine and riboxin decrease the extent of changes in the immunological response to a single administration of phenylhydrazine but do not significantly influence the immunological functions impaired by repeated injections of the hemolytic toxin.
Uteshev
B S
BS
Pharmacology Department, State Medical University, ul. Ostrovityanova 1, Moscow, 117437 Russia.
Lazareva
G A
GA
Prokopenko
L G
LG
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000743:Anemia, Hemolytic / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004195:Disease Models, Animal; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects; D010659:Phenylhydrazines; D051381:Rats; D017208:Rats, Wistar; D013831:Thiamine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D010659:Phenylhydrazines; C030299:phenylhydrazine; D007290:Inosine Diphosphate; D013831:Thiamine; C013835:benphothiamine