Macrophage intracellular signaling induced by Listeria monocytogenes.
Macrophages are critical for control of Listeria monocytogenes infections; accordingly, the interactions of L. monocytogenes with these cells have been intensively studied. It has become apparent that this facultative intracellular pathogen interacts with macrophages both prior to entry and during the intracellular phase. This review covers recent work on signaling induced in macrophages by L. monocytogenes, especially intracellular signals induced by secreted proteins including listeriolysin O and two distinct phospholipases C.
Goldfine
Howard
H
Department of Microbiology University of Pennsylvania School of Medicine, Pennsylvania, PA 19104-6076, USA. goldfinh@mail.med.upenn.edu
Wadsworth
Sandra J
SJ
D001427:Bacterial Toxins; D020013:Calcium Signaling; D006360:Heat-Shock Proteins / Q000378:metabolism; D006460:Hemolysin Proteins; D008089:Listeria monocytogenes / Q000502:physiology*; D008264:Macrophages / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology*; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010740:Phospholipases / Q000145:classification / Q000378:metabolism; D011493:Protein Kinase C / Q000145:classification / Q000378:metabolism; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism
D001427:Bacterial Toxins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D016328:NF-kappa B; D011493:Protein Kinase C; D010740:Phospholipases; D010738:Type C Phospholipases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; C038705:hlyA protein, Listeria monocytogenes