[Extracellular level of neuroactive amino acids in the rat neostriatum after treatment with psychostimulants (microdialysis study)].
The effects of acute and subchronic (four times with a 2-h interval) intraperitoneal administration of d-amphetamine and sydnocarb in equimolar doses (5 and 23.8 mg/kg, respectively) on the intracellular level of glutamate, asparate, taurine, and alanine in neostriatum of male Sprague-Dawley rats anesthetized with halothane was studied. It was shown that repeated introduction of the psychostimulants leads to a significant increase in the content of all four neuroactive amino acids in neostriatum dyalisates. However, the effects of sydnocarb were less pronounced as compared to those of d-amphetamine, which is indicative of a lower neurotoxic potential of the former drug and confirms a significant difference in the neurochemical mechanisms of action of the two drugs studied. The massive increase in the extracellular content of taurine probably reflects hyperactivation of the glutamatergic transmission in the neostriatum and may serve as a marker of neurotoxicity.
Andiarzhanova
E A
EA
Laboratory of Neurochemical Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Saransaari
R
R
Riitamaa
E
E
Oĭia
S S
SS
Raevskiĭ
K S
KS
D000818:Animals; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D003913:Dextroamphetamine / Q000633:toxicity; D018846:Excitatory Amino Acids / Q000378:metabolism*; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D017551:Microdialysis; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013558:Sydnones / Q000633:toxicity; D013654:Taurine / Q000378:metabolism
D000697:Central Nervous System Stimulants; D018846:Excitatory Amino Acids; D013558:Sydnones; D013654:Taurine; D003913:Dextroamphetamine; C009257:sidnocarb