[Elastolytic system of the pancreas in modelling diabetes mellitus].
At modelling streptozotocin and alloxan diabetes mellitus in rats we have detected an imbalance between elastase and its inhibitors (alpha 1 inhibitor of protein kinases, alpha-2 macroglobulin, acid-thermoresistant inhibitors) in tissues of the pancreas. The contribution of proelactase decreased but that of an active form of protein kinase increased; the content of alpha 1 inhibitor of protein kinase and alpha 2 macroglobulin reduced, however, the contribution of the acid-thermoresistant inhibitors in the pancreatic tissues increased. Imbalance in the system elastase-inhibitors, shown at the model of diabetes mellitus, may be an important mechanism of an exocrine insufficiency of the pancreas which results in pancreatitis.
Borysiuk
M V
MV
A.A. Bogomoletz Medical University, Kiev.
Dosenko
V Ie
VIe
Byts'
Iu V
IuV
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D008297:Male; D010179:Pancreas / Q000201:enzymology* / Q000503:physiopathology; D010196:Pancreatic Elastase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D013311:Streptozocin; D000496:Alloxan; D010196:Pancreatic Elastase