The effect of composition of poly(acrylic acid)-gelatin hydrogel on gentamicin sulphate release: in vitro.
Hydrogels based on poly(acrylic acid) and gelatin crosslinked with N,N'-methylene bisacrylamide (0.5mol%) and glutaraldehyde (4%), respectively, forming an interpenetrating network were employed as matrices, for studying the loading and release of gentamicin sulphate. The release kinetics of gentamicin sulphate was evaluated in water (pH approximately 5.8), phosphate buffer (pH 7.4) and citrate buffer (pH 4) at 37+/-0.1 degrees C. The drug release in phosphate buffer was faster as compared to water or citrate buffer. Fitting the data of release studies in Peppas model indicated that the release of drug from full IPNs in phosphate buffer (pH 7.4), water (pH approximately 5.8) and citrate buffer (pH 4) were diffusion controlled. However, semi-IPNs showed both anomalous and Fickian diffusion mechanisms. With increasing gelatin percentage in the polymer, rate of drug release was faster and almost 85% of the loaded drug was released within 7 days in phosphate buffer (pH 7.4).
Changez
Mohammad
M
Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi 110016, India.
Burugapalli
Krishna
K
Koul
Veena
V
Choudhary
Veena
V
D000180:Acrylic Resins / Q000737:chemistry* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005780:Gelatin / Q000737:chemistry*; D005839:Gentamicins / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010019:Osteomyelitis / Q000188:drug therapy
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D005839:Gentamicins; D020100:Hydrogels; C006903:carbopol 940; D005780:Gelatin