[Magnetic resonance imaging manifestation of 500 patients with primary hepatic cell carcinoma].
OBJECTIVE
Magnetic resonance imaging (MRI) is one of the main imaging diagnostic methods for primary hepatic cell carcinoma. This study was designed to summarize the MRI manifestation and to evaluate Gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) and super paramagnetic iron oxide particles(SPIO) enhanced MRI in diagnosis of small hepatic carcinoma.


METHODS
Five hundreds patients diagnosed as primary hepatic cell carcinoma histologically were examined by MRI plain scan, plain scan + Gd-DTPA enhanced T1 weighted imaging, and plain scan + Gd-DTPA T1 weighted imaging + SPIO-enhanced heavy T2 weighted imaging was performed, respectively.


RESULTS
In 500 patients, there were 65 (13.0%) small hepatic cell carcinoma, 81(16.2%) nodular lesions, 325 (65.0%) lump lesions; 29(5.8%) diffused lesions. 310(62%) patients were single lesion and the rest were multiple lesions. Twelve percent of the cases was associated with lymph nodes metastases, and 31.4% were complicated with vascular invasion. Diameter of the lesion was correlated positively to intro-hepatic metastases of the same or different lobe, the lymph nodes metastases and vascular invasion (P < 0.05). Totally 71 lesions were detected in the 65 cases with small hepatic carcinoma. Enhanced scan detected more lesions than plain scan (P < 0.05), and the lesions detected by Gd-DTPA + SPIO-enhanced scan were more than that by Gd-DTPA alone (P < 0.05).


CONCLUSIONS
With the diameter of the lesion increase, the possibility of intro-hepatic metastases, lymph node metastases, and vascular invasion increased. For the MRI diagnosis of small HCC, enhanced scan especially Gd-DTPA + SPIO enhanced scan could detect more lesions than plain scan.
Sun
Ying
Y
Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P. R. China. sy13922704708@163.net
Liang
Bi-ling
BL
Zhang
Xue-hui
XH
Shen
Jun
J
Xie
Bang-kun
BK
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography
D019786:Gadolinium DTPA