Construction of the simplest model to explain complex receptor activation kinetics.
We study the mathematical solutions to the kinetic equations arising from various simple ligand-receptor [corrected] models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exhibit features observed in some experiments, most noticeably a distinct maximum in the activity curve.
Bywater
R P
RP
Biostructure Department, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.
Sørensen
A
A
Røgen
P
P
Hjorth
P G
PG
D000818:Animals; D001711:Biotransformation; D008024:Ligands; D008954:Models, Biological; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D011956:Receptors, Cell Surface