Screening of ferritin light polypeptide 460-461InsA mutation in Parkinson's disease patients in North America.
An insertional (460-461InsA) mutation in the ferritin light polypeptide (FTL) gene was recently reported in some patients with a familial form of basal ganglia degeneration with varying extrapyramidal manifestations. Some of the affected family members presented with a phenotype indistinguishable from typical Parkinson's disease (PD). In this study, 253 patients with a clinical diagnosis of idiopathic PD were screened for the insertion in the FTL gene by polymerase chain reaction-restriction fragment length polymorphism method. The results showed that none of them had the mutation, indicating that genetic defects in the FTL gene are unlikely to be a common cause of typical PD, at least in a North America population.
Chen
Rong
R
The Parkinson's Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA. rchen@parkinsonsinstitute.org
Langston
J William
JW
Chan
Piu
P
D004252:DNA Mutational Analysis; D005091:Exons; D005260:Female; D005293:Ferritins / Q000235:genetics*; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008297:Male; D016254:Mutagenesis, Insertional; D009656:North America; D010300:Parkinson Disease / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D005293:Ferritins