title: Methods for improving limited field-of-view radiotherapy reconstructions using imperfect a priori images.
abstract: There are many benefits to having an online CT imaging system for radiotherapy, as it helps identify changes in the patient's position and anatomy between the time of planning and treatment. However, many current online CT systems suffer from a limited field-of-view (LFOV) in that collected data do not encompass the patient's complete cross section. Reconstruction of these data sets can quantitatively distort the image values and introduce artifacts. This work explores the use of planning CT data as a priori information for improving these reconstructions. Methods are presented to incorporate this data by aligning the LFOV with the planning images and then merging the data sets in sinogram space. One alignment option is explicit fusion, producing fusion-aligned reprojection (FAR) images. For cases where explicit fusion is not viable, FAR can be implemented using the implicit fusion of normal setup error, referred to as normal-error-aligned reprojection (NEAR). These methods are evaluated for multiday patient images showing both internal and skin-surface anatomical variation. The iterative use of NEAR and FAR is also investigated, as are applications of NEAR and FAR to dose calculations and the compensation of LFOV online MVCT images with kVCT planning images. Results indicate that NEAR and FAR can utilize planning CT data as imperfect a priori information to reduce artifacts and quantitatively improve images. These benefits can also increase the accuracy of dose calculations and be used for augmenting CT images (e.g., MVCT) acquired at different energies than the planning CT.
authors.affiliation: TomoTherapy, Inc., Madison, Wisconsin 53717-1954, USA. kruchala@tomotherapy.com
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Ruchala
authors.forename: Gustavo H
authors.initials: GH
authors.lastname: Olivera
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Kapatoes
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Reckwerdt
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Mackie
mesh_terms: D000465:Algorithms; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods*; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D011786:Quality Control; D011856:Radiographic Image Enhancement / Q000295:instrumentation / Q000379:methods*; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods