title: Dose-dependent effect of an oral adsorbent, AST-120, in patients with early chronic renal failure.
abstract: We evaluated the dose dependence of an oral adsorbent, AST-120, in 31 patients with early chronic renal failure (baseline serum creatinine: 1.2-3.0 mg/dl). Twenty-three patients were given AST-120 and eight patients were not. AST-120 was administered at three different maintenance doses, < 3.0 g, 3.0 g and 6.0 g/day, according to patients' ability to tolerate treatment. The treatment period was 12 months. The slope of the reciprocal of serum-creatinine concentration versus time was calculated to assess the progression of renal failure. This slope became significantly less steep after AST-120 treatment at 6.0 g/day, but did not change significantly at the other doses. These findings suggest that 6.0 g/day of AST-120 may delay the initiation of dialysis in patients with early chronic renal failure.
authors.affiliation: Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. nyorioka@hiroshima-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Yorioka
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Masaki
authors.forename: S
authors.initials: S
authors.lastname: Ogata
authors.forename: Y
authors.initials: Y
authors.lastname: Asakimori
authors.forename: C
authors.initials: C
authors.lastname: Tanji
authors.forename: Y
authors.initials: Y
authors.lastname: Kyuden
authors.forename: Y
authors.initials: Y
authors.lastname: Komiya
authors.forename: J
authors.initials: J
authors.lastname: Kumagai
authors.forename: Y
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Kohno
mesh_terms: D000284:Administration, Oral; D000327:Adsorption; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002244:Carbon / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000008:administration & dosage*; D017582:Renal Replacement Therapy; D014118:Toxins, Biological / Q000302:isolation & purification
chemical_list: D010087:Oxides; D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D002244:Carbon; C040896:AST 120; D003404:Creatinine