title: [Bladder cancer chemotherapy practice study].
abstract: OBJECTIVE
  To study chemotherapy practice in invasive bladder cancer in a cancer centre (Centre Léon Bérard).
  
  
  METHODS
  This retrospective study concerned all patients treated by chemotherapy between 1994 and 2000, either in the adjuvant setting (38) or for metastatic disease (66).
  
  
  RESULTS
  Twenty four of the 38 patients receiving adjuvant chemotherapy were treated with MVAC, 21% developed febrile neutropenia and 60% relapsed. The median recurrence-free survival was 12 months. In patients treated for metastatic disease, the objective response rate was 36% and the median survival with advanced disease after chemotherapy was 10 months. These results are in line with those reported in large-scale randomized trials. The toxicity of chemotherapy was also fairly high (21% of febrile neutropenia).
  
  
  CONCLUSIONS
  Prospective studies help to optimize chemotherapy protocols, but practice studies show the limited results and the high toxicity. The benefit/risk ratio must be carefully considered.
authors.affiliation: Département d'Oncologie Médicale, Centre Léon Bérard, Lyon, France. christine.clippe@chu-lyon.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Clippe
authors.forename: Sébastien
authors.initials: S
authors.lastname: Clippe
authors.forename: Delphine
authors.initials: D
authors.lastname: Yzebe
authors.forename: Aude
authors.initials: A
authors.lastname: Flechon
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Droz
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate