Fuzzy neural network applied to gene expression profiling for predicting the prognosis of diffuse large B-cell lymphoma.
Diffuse large B-cell lymphoma (DLBCL) is the largest category of aggressive lymphomas. Less than 50% of patients can be cured by combination chemotherapy. Microarray technologies have recently shown that the response to chemotherapy reflects the molecular heterogeneity in DLBCL. On the basis of published microarray data, we attempted to develop a long-overdue method for the precise and simple prediction of survival of DLBCL patients. We developed a fuzzy neural network (FNN) model to analyze gene expression profiling data for DLBCL. From data on 5857 genes, this model identified four genes (CD10, AA807551, AA805611 and IRF-4) that could be used to predict prognosis with 93% accuracy. FNNs are powerful tools for extracting significant biological markers affecting prognosis, and are applicable to various kinds of expression profiling data for any malignancy.
Ando
Tatsuya
T
Department of Biotechnology, School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.
Suguro
Miyuki
M
Hanai
Taizo
T
Kobayashi
Takeshi
T
Honda
Hiroyuki
H
Seto
Masao
M
D004268:DNA-Binding Proteins / Q000235:genetics; D020869:Gene Expression Profiling; D006801:Humans; D050835:Interferon Regulatory Factors; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000401:mortality; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000401:mortality; D015260:Neprilysin / Q000235:genetics; D016571:Neural Networks, Computer; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D014157:Transcription Factors / Q000235:genetics; D000099218:Interferon Regulatory Factor-4
D004268:DNA-Binding Proteins; D050835:Interferon Regulatory Factors; D015260:Neprilysin; D014157:Transcription Factors; D000099218:Interferon Regulatory Factor-4