title: Synthesis and biological evaluation of aristolactams.
abstract: A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line.
authors.affiliation: Laboratoire de Chimie Organique Physique, ESA CNRS 8009, Bâtiment C3(2), UST Lille, F-59655 Villeneuve d'Ascq Cédex, France. axel.couture@univ-lille1.fr
authors.forename: Axel
authors.initials: A
authors.lastname: Couture
authors.forename: Eric
authors.initials: E
authors.lastname: Deniau
authors.forename: Pierre
authors.initials: P
authors.lastname: Grandclaudon
authors.forename: Hélène
authors.initials: H
authors.lastname: Rybalko-Rosen
authors.forename: Stéphane
authors.initials: S
authors.lastname: Léonce
authors.forename: Bruno
authors.initials: B
authors.lastname: Pfeiffer
authors.forename: Pierre
authors.initials: P
authors.lastname: Renard
mesh_terms: D000818:Animals; D034341:Aristolochic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007769:Lactams; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D034341:Aristolochic Acids; D007769:Lactams