Serum concentrations of elastin-derived peptides in patients with specific manifestations of atherosclerotic disease.
OBJECTIVE
To measure serum concentrations of elastin-derived peptides (S-EDP) in patients with aneurysmal, occlusive and ulcerative manifestations of atherosclerotic disease.


METHODS
S-EDP concentrations were measured by a competitive enzyme-linked immunosorbent assay in 10 patients with infrarenal aneurysms 5cm in diameter (AAA), 10 patients with distal aortic occlusive disease (AOD), 10 patients with symptomatic carotid stenosis (>or=70%) and plaque ulceration (SCS) and a control group of 10 patients with no similar specific manifestations of atherosclerotic disease (NAM).


RESULTS
S-EDP concentrations (median, range) were significantly higher in patients with AAA (42ng/ml, 35-52, p<0.001) and SCS (49ng/ml, 37-60, p<0.001) but not AOD (28ng/ml, 22-38, p=0.240) compared to NAM (26ng/ml, 19-36) patients.


CONCLUSIONS
Increased concentrations of S-EDP were associated with aneurysmal and ulcerative, but not occlusive, manifestations of atherosclerosis.
Petersen
E
E
Department of Surgery, Umeå University Hospital, Umeå, Sweden.
Wågberg
F
F
Angquist
K-A
KA
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000209:etiology; D001018:Aortic Diseases / Q000097:blood / Q000209:etiology; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000209:etiology; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications; D016893:Carotid Stenosis / Q000097:blood / Q000209:etiology; D004549:Elastin; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications; D012907:Smoking / Q000453:epidemiology; D018709:Statistics, Nonparametric
D010455:Peptides; D004549:Elastin