title: Therapy of peptic ulcer with semax peptide.
abstract: Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers. On day 14 of treatment ulcer healing was observed in 89.5% patients receiving intranasal Semax (1% solution, 2-4 drops 3 times a day for 10 days) vs. 30.8% in the control group. Clinical studies of antiulcer activity of Semax in different combinations with usual antiulcer drugs are needed.
authors.affiliation: Medical Center of President's Administration, Central Clinical Hospital, Moscow.
authors.forename: I O
authors.initials: IO
authors.lastname: Ivanikov
authors.forename: M E
authors.initials: ME
authors.lastname: Brekhova
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000188:drug therapy*; D010446:Peptide Fragments / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D018697:Nootropic Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone