Recent glimpses of the elusive spindle matrix.
A stationary spindle matrix has been proposed on theoretical grounds to help mediate force production at the mitotic spindle. Direct molecular evidence for the existence of such a matrix has the potential to profoundly influence our view of the molecular mechanisms leading to chromosome segregation during mitosis. Three recent papers suggest that the spindle matrix may be more than a theoretical idea.
Johansen
Kristen M
KM
Department of Zoology and Genetics, Iowa State University, 3154 Molecular Biology Building, Ames, Iowa 50011, USA. kristen@iastate.edu
Johansen
Jorgen
J
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D004330:Drosophila / Q000166:cytology; D029721:Drosophila Proteins / Q000502:physiology; D016547:Kinesins / Q000737:chemistry / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D034521:Nuclear Matrix-Associated Proteins / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology*; D029867:Xenopus Proteins / Q000502:physiology
D002868:Chromosomal Proteins, Non-Histone; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; C456282:FIN1 protein, S cerevisiae; C088335:KIF11 protein, Xenopus; D034521:Nuclear Matrix-Associated Proteins; D029701:Saccharomyces cerevisiae Proteins; D029867:Xenopus Proteins; C419556:skeletor protein, Drosophila; D016547:Kinesins