title: New structure involved in transient membrane fusion and exocytosis.
abstract: Our studies using atomic force microscopy (AFM) reveal a new group of plasma membrane structures involved in exocytosis in live pancreatic acinar cells. These studies demonstrate that "pits" and "depressions" are sites at the apical plasma membrane in live cells, where membrane-bound secretory vesicles dock and transiently fuse to release vesicular contents.
authors.affiliation: Department of Physiology and Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Cho
authors.forename: A
authors.initials: A
authors.lastname: Wakade
authors.forename: G D
authors.initials: GD
authors.lastname: Pappas
authors.forename: B P
authors.initials: BP
authors.lastname: Jena
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D019439:Chromaffin Cells / Q000166:cytology* / Q000648:ultrastructure*; D004594:Electrophysiology; D005089:Exocytosis; D008561:Membrane Fusion; D018625:Microscopy, Atomic Force; D051381:Rats