Antimicrobial triterpenes from Debregeasia salicifolia.
New triterpene, 3beta-(trans-cinnamoyloxy)-19alpha-hydroxy-urs-12-ene (1) has been isolated from the methanolic fraction of Debregeasia salicifolia, along with uvaol (2), 3beta,19alpha-dihydroxy-urs-12-ene (3), ursolic acid (4), pomolic acid (5), pomolic acid methyl ester (6) and tormentic acid (7) reported for the first time from this species. The compounds (1), (3) and (6) showed significant antimicrobial activity. The structure elucidation was made with the help of extensive 2D NMR spectroscopic techniques.
Akbar
Erum
E
International Center for Chemical Sciences, H.E.J Research Institute of Chemistry, University of Karachi, Pakistan.
Malik
Abdul
A
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002934:Cinnamates / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D027003:Urticaceae / Q000737:chemistry*
C470599:3-(cinnamoyloxy)-19-hydroxy-urs-12-ene; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002934:Cinnamates; D014315:Triterpenes