August rats are more resistant to arrhythmogenic effect of myocardial ischemia and reperfusion than Wistar rats.
As differentiated from Wistar rats, myocardial ischemia and reperfusion produce no ventricular fibrillation in August rats. Pretreatment with nitric oxide synthase inhibitor Nw-nitro-L-arginine increased mortality rate in August rats with acute myocardial infarction from 20 to 40%. Under these conditions mortality rate in Wistar rats increased from 50 to 71%. Interstrain differences in the resistance of these animals to the arrhythmogenic effect of ischemia are probably associated with higher activity of the nitric oxide system in August rats compared to Wistar rats.
Belkina
L M
LM
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Kirillina
T N
TN
Pshennikova
M G
MG
Arkhipenko
Yu V
YV
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications* / Q000401:mortality; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000401:mortality; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000187:drug effects; D019335:Nitroarginine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013045:Species Specificity
D004791:Enzyme Inhibitors; D019335:Nitroarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase