The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity.
Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes. This article gives a short overview on DP IV/CD26 expression and effects on immune cells in vitro and in vivo. A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as therapeutics in inflammatory disorders.
Reinhold
Dirk
D
Institute of Immunology, Otto-von-Gueircke University Magdeburg, Germany.
Kähne
Thilo
T
Steinbrecher
Andreas
A
Wrenger
Sabine
S
Neubert
Klaus
K
Ansorge
Siegfried
S
Brocke
Stefan
S
D000818:Animals; D015551:Autoimmunity; D018819:Dipeptidyl Peptidase 4 / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D011480:Protease Inhibitors / Q000276:immunology / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000201:enzymology* / Q000276:immunology
D011480:Protease Inhibitors; D018819:Dipeptidyl Peptidase 4