Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis.
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS). Treatment with LIF at the onset of the disease showed a slight, but not significant, improvement in the clinical course but no effect on nerve histology.
Laurà
M
M
Department of Neurological Sciences, Psychiatry and Anaesthesiology, University of Messina, 98125, Messina, Italy. matilde.laura@tin.it
Gregson
N A
NA
Curmi
Y
Y
Hughes
R A C
RA
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D001835:Body Weight / Q000187:drug effects / Q000276:immunology; D002420:Cauda Equina / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006131:Growth Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D020275:Guillain-Barre Syndrome / Q000188:drug therapy*; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000494:pharmacology* / Q000627:therapeutic use; D009186:Myelin Sheath / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013126:Spinal Nerve Roots / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D016896:Treatment Outcome; D014855:Wallerian Degeneration / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines