title: Antibacterial activity of moxifloxacin against periodontal anaerobic pathogens involved in systemic infections.
abstract: The in vitro activity of moxifloxacin was compared with that of penicillin G, amoxycillin/clavulanate, cefoxitin, erythromycin, clindamycin and metronidazole against 158 isolates associated with periodontal infections. MIC(50)/MIC(90) values of moxifloxacin were respectively 0.06/0.5 mg/l for Porphyromonas gingivalis (35), for Prevotella spp. (28) and Actinomyces spp. (35), 0.12/0.25 mg/l for Fusobacterium nucleatum (20) and 0.06/0.12 mg/l for Peptostreptococcus spp. (30). The minimum inhibitory concentration (MIC) range of moxifloxacin for Bacteroides forsythus (6) and Campylobacter rectus (4) was 0.06-0.12 mg/l. The minimum bactericidal concentrations were equal to or 2-4 times the MIC values. Moxifloxacin produced a bactericidal effect at 8 h. Our results show that moxifloxacin has good antibacterial activity against periodontal pathogens comparable with that of cefoxitin and amoxycillin/clavulanate, and better than that of clindamycin, metronidazole and penicillin.
authors.affiliation: Department of Microbiological and Gynaecological Sciences - Section of Microbiology, University of Catania, Via Androne, 81, 95124 Catania, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Milazzo
authors.forename: G
authors.initials: G
authors.lastname: Blandino
authors.forename: R
authors.initials: R
authors.lastname: Musumeci
authors.forename: G
authors.initials: G
authors.lastname: Nicoletti
authors.forename: A M
authors.initials: AM
authors.lastname: Lo Bue
authors.forename: A
authors.initials: A
authors.lastname: Speciale
mesh_terms: D000693:Anaerobiosis / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D024841:Fluoroquinolones; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D010510:Periodontal Diseases / Q000382:microbiology*; D011804:Quinolines; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin