title: Fetal magnetoencephalography in intrauterine growth retarded pregnancies.
abstract: OBJECTIVE
  To investigate the fetal brain activity in pre-eclamptic and normal pregnancies. Biomagnetic measurements were performed by means of a superconducting quantum interference device (SQUID) in an electrically shielded room of low magnetic noise.
  
  
  METHODS
  The study population included 28 pre-eclamptic (34-37 weeks' gestation) and 19 normal pregnancies (34-37 weeks' gestation). The pre-eclamptic group consisted of 11 cases with birth weight below the 10th percentile (1969 +/- 129 g) and 17 cases above the 10th percentile (2496 +/- 257 g). Biomagnetic signals (waveforms) recorded from fetal brains were expressed in terms of magnetic power spectral amplitudes.
  
  
  RESULTS
  The total corresponding spectral amplitudes in the frequency range 2-7 Hz were high (719 +/- 69 Ft/ radical Hz in neonates <10th percentile and 537 +/- 105 Ft/ radical Hz in neonates >10th percentile) in most (82%) pre-eclamptic pregnancies and low (382 +/- 35 Ft/ radical Hz) in most normal pregnancies (95%). The difference between normal and all pre-eclamptic pregnancies was highly significant (Student's t-test: p < 0.0001). Comparing the two groups of pre-eclampsia we found also a highly significant difference (Student's t-test: p < 0.0001).
  
  
  CONCLUSIONS
  Biomagnetic measurements of fetal brain activity could be useful in the assessment of fetal central nervous system development.
authors.affiliation: Laboratory of Medical Physics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Athanasia
authors.initials: A
authors.lastname: Kotini
authors.forename: Nikoleta
authors.initials: N
authors.lastname: Koutlaki
authors.forename: Photios
authors.initials: P
authors.lastname: Anninos
authors.forename: Vasilios
authors.initials: V
authors.lastname: Liberis
authors.forename: Athanasios
authors.initials: A
authors.lastname: Hatzimihael
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Anastasiadis
mesh_terms: D000328:Adult; D001724:Birth Weight; D001921:Brain / Q000196:embryology / Q000503:physiopathology; D001927:Brain Diseases / Q000151:congenital / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D015225:Magnetoencephalography / Q000295:instrumentation / Q000379:methods*; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000379:methods*