title: Chromosomal localization of genes involved in biosynthesis, metabolism or transport of cholesterol in the rat.
abstract: Several genes involved in biosynthesis, transport or metabolism of cholesterol have been localized on rat chromosomes by using a radiation hybrid (RH) panel. The genes, coding for squalene epoxidase (Sqle), mevalonate kinase (Mvk), and farnesyl diphosphate farnesyl transferase 1 (Fdft1) which are involved in cholesterol biosynthesis, have been mapped on chromosome 7, 12, and 15, respectively. The genes coding for phospholipid transfer protein (Pltp), sterol carrier protein-2 (Scp2), ATP binding cassette reporter A7 (Abca7), scavenger receptor class B, type 1 (Cd36l1), steroidogenic acute regulatory protein (Star), and lecithin:cholesterol acyl transferase (Lcat), which are involved in the transfer and/or metabolism of cholesterol, have been mapped on chromosome 3, 5, 7, 12, 16, and 19, respectively. Each of the genes Scp2, Sqle and Fdft1 maps close to a QTL for serum total cholesterol in rat, suggesting that these three genes might represent candidate genes for the previously mapped QTLs.
authors.affiliation: Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands. Bonne@las.vet.uu.nl
authors.forename: A C M
authors.initials: AC
authors.lastname: Bonné
authors.forename: M G
authors.initials: MG
authors.lastname: den Bieman
authors.forename: G F
authors.initials: GF
authors.lastname: Gillissen
authors.forename: H A
authors.initials: HA
authors.lastname: van Lith
authors.forename: L F M
authors.initials: LF
authors.lastname: van Zutphen
mesh_terms: D000818:Animals; D001483:Base Sequence; D001692:Biological Transport; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D002874:Chromosome Mapping; D017931:DNA Primers; D040641:Quantitative Trait Loci; D051381:Rats
chemical_list: D017931:DNA Primers; D002784:Cholesterol