[Extracorporeal photochemotherapy in therapy-refractory subacute lupus].
BACKGROUND
Extracorporeal photopheresis is a leukapheresis therapy that uses psoralen and ultraviolet A irradiation. We report the case of a woman with a refractory sub acute lupus which dramatically but transitionally responded to extracorporeal photopheresis.


METHODS
This women, born in 1960, developed erythematous and squamous patches located on face and neckline, associated with hyperpigmented and atrophic lesions on the arms and shoulders. Investigations confirmed the diagnosis of subacute lupus without systemic disease. All lesions progressed, despite all conventional therapies leading to major aesthetic prejudice. Extracorporeal photopheresis was initiated, and after two months, all lesions, including atrophic and healing lesions had regressed, but laboratory abnormalities did not change. Extracorporeal photopheresis was well tolerated. However, treatment was discontinued nine months later, since the cutaneous lesions relapsed.


CONCLUSIONS
Extracorporeal photopheresis could be efficient in the treatment of cutaneous autoimmune diseases through several immunomodulatory mechanisms. Extracorporeal photopheresis is a potent alternative agent in the therapy of refractory dermatological diseases
Richard
M A
MA
Service de Dermatologie, Hôpital Sainte Marguerite, Marseille, France. mrichard@mail.ap-hm.fr
Saadallah
S
S
Lefevre
P
P
Poullin
P
P
Buscaylet
S
S
Grob
J J
JJ
D000328:Adult; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage*; D008177:Lupus Vulgaris / Q000175:diagnosis / Q000188:drug therapy*; D017893:Photopheresis; D012008:Recurrence; D013997:Time Factors
D003879:Dermatologic Agents; D006886:Hydroxychloroquine