Therapy of peptic ulcer with semax peptide.
Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers. On day 14 of treatment ulcer healing was observed in 89.5% patients receiving intranasal Semax (1% solution, 2-4 drops 3 times a day for 10 days) vs. 30.8% in the control group. Clinical studies of antiulcer activity of Semax in different combinations with usual antiulcer drugs are needed.
Ivanikov
I O
IO
Medical Center of President's Administration, Central Clinical Hospital, Moscow.
Brekhova
M E
ME
Samonina
G E
GE
Myasoedov
N F
NF
Ashmarin
I P
IP
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000188:drug therapy*; D010446:Peptide Fragments / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D018696:Neuroprotective Agents; D018697:Nootropic Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone