title: Nutraceutical production with food-grade microorganisms.
abstract: Over the past few years a number of new food ingredients labelled as being nutraceuticals have been launched on the food and pharmaceutical market. These include components that have a proven beneficial effect on human health, such as low-calorie sugars and B vitamins. Lactic acid bacteria, in particular Lactococcus lactis, have been demonstrated to be ideal cell factories for the production of these important nutraceuticals. Developments in the genetic engineering of food-grade microoganisms means that the production of certain nutraceuticals can be enhanced or newly induced through overexpression and/or disruption of relevant metabolic genes.
authors.affiliation: Wageningen Centre for Food Sciences, PO Box 20, 6710 BA Ede, The Netherlands. hugenhol@nizo.nl
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hugenholtz
authors.forename: Eddy J
authors.initials: EJ
authors.lastname: Smid
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001419:Bacteria / Q000145:classification / Q000378:metabolism; D050260:Carbohydrate Metabolism; D005492:Folic Acid / Q000096:biosynthesis; D006601:Hexoses / Q000096:biosynthesis; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D013294:Lactococcus lactis / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D008353:Mannitol / Q000378:metabolism; D019936:Probiotics / Q000008:administration & dosage / Q000378:metabolism*; D012256:Riboflavin / Q000096:biosynthesis; D013012:Sorbitol / Q000378:metabolism; D013045:Species Specificity; D014199:Trehalose / Q000096:biosynthesis; D014805:Vitamin B 12 / Q000096:biosynthesis
chemical_list: D000975:Antioxidants; D006601:Hexoses; D008353:Mannitol; D013012:Sorbitol; D005492:Folic Acid; D014199:Trehalose; D014805:Vitamin B 12; C030192:tagatose; D012256:Riboflavin