title: Structure and absolute configuration of new diterpenes from Lavandula multifida.
abstract: Four new diterpenes (1-4) have been isolated from the aerial parts of Lavandula multifida, together with the known compound glutinosin (5). The structures of these compounds were identified on the basis of extensive NMR studies as 15,16-dihydroxy-7,11-dioxopimar-8(9)-ene (1), 15S,16-dihyroxy-7-oxopimar-8(9)-ene (2), 15,16,17-trihydroxy-7-oxopimar-8(9)-ene (3), and 15,16,17-trihydroxypimar-8(9)-ene (4). The absolute configuration of the 15,16-diol moiety in 1-5 was determined observing the circular dichroism induced after addition of dimolybdenum tetracetate in DMSO solution.
authors.affiliation: Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Politi
authors.forename: Nunziatina
authors.initials: N
authors.lastname: De Tommasi
authors.forename: Gennaro
authors.initials: G
authors.lastname: Pescitelli
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Di Bari
authors.forename: Ivano
authors.initials: I
authors.lastname: Morelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Braca
mesh_terms: D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D027523:Lavandula / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009018:Morocco; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; C471534:glutinosin