title: Platelet monoamine oxidase activity in a nonhuman primate model of type 2 excessive alcohol consumption.
abstract: OBJECTIVE
  Low platelet monoamine oxidase (MAO) activity is associated with "type 2 alcoholism." MAO activity is also affected by cigarette smoking. Since most alcoholics are smokers, it is difficult to evaluate the possible effect of platelet MAO activity on alcoholism independently of the effects of smoking. The authors investigated the relationship between platelet MAO activity and excessive alcohol consumption in rhesus macaques.
  
  
  METHODS
  Platelet MAO activity and CSF metabolite concentrations were measured. The authors also investigated level of voluntary alcohol intake and social dominance rank.
  
  
  RESULTS
  Subjects with low platelet MAO activity consumed alcohol to excess, had low CSF 5-hydroxyindoleacetic acid concentrations, and were less competent socially.
  
  
  CONCLUSIONS
  These findings show that nonhuman primates that exhibit type 2-like alcohol features display low platelet MAO activity and support the notion that platelet MAO activity is a biologic marker for central serotonergic activity. The results also challenge the hypothesis that low platelet MAO activity in type 2 alcoholism is simply an artifact of smoking.
authors.affiliation: Department of Psychology, Göteborg University, PO Box 500, SE-405 30 Göteborg, Sweden. Claudia.Fahlke@psy.gu.se
authors.forename: Claudia
authors.initials: C
authors.lastname: Fahlke
authors.forename: Håkan
authors.initials: H
authors.lastname: Garpenstrand
authors.forename: Lars
authors.initials: L
authors.lastname: Oreland
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Suomi
authors.forename: J Dee
authors.initials: JD
authors.lastname: Higley
mesh_terms: D000428:Alcohol Drinking / Q000453:epidemiology / Q000378:metabolism*; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D005260:Female; D008253:Macaca mulatta; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012930:Social Dominance
chemical_list: D008995:Monoamine Oxidase