[Influence of hypoxia and anoxia on endothelium-dependent dilatation response of rat's aorta exposed to low-intensity gamma irradiation].
The study of isolated segments of aorta has shown that prolongated exposure of rats to gamma-radiation with 50 cGy dose (with a dose rate of 2.8 x 10(7) Gy/s) causes the decrease in endothelium-dependent dilatation responses to M-cholinoreceptors stimulation. During oxygenation the post-radiation changes are displayed within one month, and under functional loads, specifically, during perfusion by hypoxic and anoxic solutions--in more remote terms of the post-radiation period.
Lobanok
L M
LM
Institute of Radiobiology, Belarus Academy of Sciences, Minsk, 220041 Belarus. leo@radbio.bas-net.by
Luksha
N P
NP
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000528:radiation effects*; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D004730:Endothelium, Vascular / Q000187:drug effects / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D066298:In Vitro Techniques; D010100:Oxygen / Q000008:administration & dosage; D011829:Radiation Dosage; D051381:Rats; D012996:Solutions; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects / Q000528:radiation effects*
D018679:Cholinergic Agonists; D012996:Solutions; D002217:Carbachol; D010100:Oxygen