Autoimmune progesterone dermatitis.
Autoimmune progesterone dermatitis (APD) is an uncommon cutaneous disorder characterized by exacerbations during the luteal phase of the menstrual cycle. We describe a 27-year-old woman with a recurrent skin eruption for 3 years. She had no history of exposure to synthetic progesterones. At each menses, the patient developed scaly, erythematous maculopapular lesions over the face. Intradermal skin test reaction to progesterone was positive. Progesterone sensitivity was also demonstrated by challenge test with intramuscular progesterone acetate. These features were consistent with the diagnosis of APD. Our patient was treated successfully with conjugated estrogen for 6 months. At one year follow-up, the patient had had no recurrence of facial eruption.
Oskay
Tuğba
T
Department of Dermatology, Bayindir Medical Centre Ankara, Mesa Park Sitesi, Sedir Apt. Daire: 44, 06450 Oran/Ankara/Turkey. tubaoskay@hotmail.com
Kutluay
Lale
L
Kaptanoğlu
Asli
A
Karabacak
Onur
O
D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000473:pathology*; D001707:Biopsy, Needle; D003872:Dermatitis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D004954:Esthetics; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008597:Menstrual Cycle / Q000276:immunology; D010507:Periodicity; D011374:Progesterone / Q000276:immunology*; D016896:Treatment Outcome
D004966:Estrogens, Conjugated (USP); D011374:Progesterone