title: Multicentric parenchymal xanthogranuloma in a child: case report and review of the literature.
abstract: OBJECTIVE
  Xanthogranulomas of the central nervous system are rare, and asymptomatic lesions are often identified in autopsies. We report the first case of a multicentric, cystic, intraparenchymal xanthogranuloma, involving both the supra- and infratentorial compartments, in a 16-month-old girl.
  
  
  METHODS
  The clinical presentation consisted of a focal motor seizure in an otherwise healthy infant.
  
  
  METHODS
  Gross total removal of the infratentorial lesion was accomplished via a midline suboccipital craniotomy.
  
  
  CONCLUSIONS
  Intracranial xanthogranulomas are rare, and limited experience with the diagnosis of these lesions has been reported. Although most cases are asymptomatic, this case involves a symptomatic, multicentric, intraparenchymal xanthoma in a pediatric patient. Our review of the literature provides further insights regarding the clinical, radiological, and pathological behavior of these lesions and examines the available treatment strategies.
authors.affiliation: Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Lesniak
authors.forename: Michael P
authors.initials: MP
authors.lastname: Viglione
authors.forename: Jon
authors.initials: J
authors.lastname: Weingart
mesh_terms: D003399:Craniotomy; D003560:Cysts / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery