Complete cDNA sequence, expression, alternative splicing, and genomic organization of the mouse Nfat5 gene.
Members of the NFAT (nuclear factors of activated T cells) gene family have been investigated in numerous organisms, including man and mouse. All NFATs may be synthesized in several isoforms differing in amino or carboxy termini due to 5' and 3' alternative splicing of the corresponding mRNA. Recently, we mapped the murine Nfat5 gene to chromosome 8D. In the present paper we describe for the first time the complete sequence and primary structure of murine Nfat5, two new spliced isoforms, and the expression of murine Nfat5 in embryonic and adult mouse tissues.
Dalski
A
A
Institut fü Humangenetik, Universität Lübeck, Lübeck, Germany.
Hebinck
A
A
Winking
H
H
Butzmann
U
U
Schwinger
E
E
Zühlke
Ch
Ch
D017398:Alternative Splicing; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D050778:NFATC Transcription Factors; D016133:Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics*
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D014157:Transcription Factors