[Intravenous cyclosporine A in the treatment of refractory Crohn's disease].
BACKGROUND
Intravenous cyclosporine (iv CyA) is efficient in ulcerative colitis, but data are scarce in Crohn's disease (CD).


METHODS
Patients with CD refractory to standard therapy who were treated with iv CyA.


RESULTS
All patients with steroid-refractory disease achieved a complete response. In perianal disease, a complete response was attained in 3 out of 16 patients, while 9 showed a partial response. Only 1 out of 8 patients with enteric fistulae showed a complete response and a further one had a partial response.


CONCLUSIONS
Intravenous CyA seems to be useful in steroid-refractory CD but not in fistulizing CD.
García-Planella
Esther
E
Servicio de Aparato Digestivo. Hospital Universitari Germans Trias i Pujol. Badalona. Barcelona. España.
Domènech
Eugeni
E
Cabré
Eduard
E
Bernal
M Isabel
MI
Gassull
Miquel Angel
MA
D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine