Evidence for constitutive expression of bovine adrenal a3beta4* nicotinic acetylcholine receptors.
Many pathological conditions involve alterations in expression of nicotinic acetylcholine receptors (nAChRs). The following studies were designed to investigate cellular mechanisms involved with expression and turnover of alpha3beta4* nAChRs. These studies support constitutive turnover of adrenal alpha3beta4* nAChRs and the use of cultured adrenal chromaffin cells to study nAChR regulation.
Free
R Benjamin
RB
Division of Pharmacology, The Ohio State University, College of Pharmacy, Columbus, Ohio 43210, USA.
McKay
Susan B
SB
Boyd
R Thomas
RT
McKay
Dennis B
DB
D000818:Animals; D002417:Cattle; D019439:Chromaffin Cells / Q000378:metabolism*; D015536:Down-Regulation; D005786:Gene Expression Regulation; D011691:Puromycin / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000096:biosynthesis* / Q000235:genetics*; D013997:Time Factors
D011978:Receptors, Nicotinic; C403530:nicotinic receptor alpha3beta4; D011691:Puromycin