title: Comparison of macroscopic models of excitation and force propagation in the heart.
abstract: Computer aided simulations of the heart provide knowledge of phenomena, which are commonly neither visible nor measurable with current techniques. This knowledge can be applied e.g. in cardiologic diagnosis and therapy. A variety of models was created to reconstruct cardiac processes, e.g. electrical propagation and force development. In this work different macroscopic models were compared, i.e. models based on excitation-diffusion equations and cellular automata. The comparison was carried out concerning reconstruct-ability of cardiac phenomena, mathematical and biophysical foundation as well as computational expense. Particularly, the reconstruct-ability of electromechanic feedback mechanisms was examined. Perspectives for further developments and improvements of models were given.
authors.affiliation: Institut für Biomedizinische Technik, Universität Karlsruhe (TH), Germany. Frank.Sachse@ibt.uni-karlsruhe.de
authors.forename: F B
authors.initials: FB
authors.lastname: Sachse
authors.forename: L G
authors.initials: LG
authors.lastname: Blümcke
authors.forename: M
authors.initials: M
authors.lastname: Mohr
authors.forename: K
authors.initials: K
authors.lastname: Glänzel
authors.forename: J
authors.initials: J
authors.lastname: Häfner
authors.forename: C
authors.initials: C
authors.lastname: Riedel
authors.forename: G
authors.initials: G
authors.lastname: Seemann
authors.forename: O
authors.initials: O
authors.lastname: Skipa
authors.forename: C D
authors.initials: CD
authors.lastname: Werner
authors.forename: O
authors.initials: O
authors.lastname: Dössel
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D004562:Electrocardiography; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009200:Myocardial Contraction / Q000502:physiology*; D017711:Nonlinear Dynamics