title: Oxidative stress in patients with primary pulmonary hypertension.
abstract: We studied the role of oxidative stress in the pathogenesis of primary pulmonary hypertension. In patients with primary pulmonary hypertension the content of malonic dialdehyde in the plasma was higher than in healthy volunteers (5.18 0.46 and 2.95 0.14 nmol/liter, respectively, p<0.01). However, glutathione peroxidase activity in the plasma decreased in these patients (0.50 0.17 vs. 1.19 0.14 U/ml in the control, p<0.05). By contrast, glutathione peroxidase activity in erythrocytes from patients surpassed the control (6.13 0.39 and 4.63 0.45 U/h hemoglobin). The increase in malonic dialdehyde content in the plasma and glutathione peroxidase activity in erythrocytes and the decrease in glutathione peroxidase activity in the plasma were most pronounced in patients with severe cardiac insufficiency and pulmonary hypertension. Our results indicate that antioxidant preparations improve the prognosis in patients with primary pulmonary hypertension.
authors.affiliation: Department of Systemic Hypertensions, Laboratory of Biochemistry of Free Radical Processes, A. L. Myasnikov Institute of Cardiology, Russian Cardiology Research-and-Production Center, Russian Ministry of Health, Moscow.
authors.forename: N L
authors.initials: NL
authors.lastname: Irodova
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.forename: G K
authors.initials: GK
authors.lastname: Konovalova
authors.forename: A G
authors.initials: AG
authors.lastname: Kochetov
authors.forename: I E
authors.initials: IE
authors.lastname: Chazova
mesh_terms: D000293:Adolescent; D000328:Adult; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000201:enzymology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase