Experimental models in focal cerebral ischemia: are we there yet?
Therapeutic options available for acute stroke management are sparse and inadequate. Therefore, new insights into stroke pathophysiology leading to new therapeutic targets are needed. In order to attain these goals, adequate animal models for cerebral ischemia are needed. In the following paper the authors will review the various animal models for stroke and emphasize their potential strengths and weaknesses.
Leker
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Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel.
Constantini
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D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology* / Q000628:therapy; D002470:Cell Survival / Q000502:physiology; D002544:Cerebral Infarction / Q000503:physiopathology* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D020243:Infarction, Anterior Cerebral Artery / Q000503:physiopathology / Q000628:therapy; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology / Q000628:therapy; D020766:Intracranial Embolism / Q000503:physiopathology / Q000628:therapy; D002546:Ischemic Attack, Transient / Q000503:physiopathology / Q000628:therapy; D051379:Mice; D009474:Neurons / Q000502:physiology; D051381:Rats