Severe arteriolar lesion mimicking drug-induced arteriolopathy in a long-term surviving renal allograft.
We report severe arteriolar lesion mimicking drug-induced arteriolopathy in a renal allograft of a 37-year-old Japanese male, who has been treated by conventional immunosuppressive therapy but not administered cyclosporin or tacrolimus for 16 years after renal transplantation. Renal biopsy also showed glomerular changes including transplant glomerulopathy and features of chronic vascular rejection. The cause of the arteriolar lesion remains uncertain. Although its pathogenesis may be multi-factorial, long-term usage of conventional immunosuppressive agents and/or vascular rejection may contribute to the occurrence of the arteriolar lesion. We propose that biopsy study is needed for further understanding of histopathological behaviours of renal grafts in long-term survivors.
Nazneen
Arifa
A
Department of Pathology, Nagasaki University School of Medicine, and Renal Care Unit, Nagasaki University Hospital, Japan.
Nishikido
Masaharu
M
Koga
Shigehiko
S
Kanetake
Hiroshi
H
Liu
Diange
D
Harada
Takashi
T
Taguchi
Takashi
T
D000328:Adult; D001160:Arterioles / Q000648:ultrastructure*; D001706:Biopsy; D003937:Diagnosis, Differential; D006084:Graft Rejection / Q000473:pathology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male