title: In vitro activities of Garenoxacin (BMS 284756) against 108 clinical isolates of Gardnerella vaginalis.
abstract: Garenoxacin (BMS 284756) was active against 105 of 108 (97%) recent clinical Gardnerella vaginalis isolates at < or =2 micro g/ml by using the reference agar dilution method for anaerobes. Twenty-eight percent of isolates (31 of 108) were resistant to metronidazole, and 44% were resistant to doxycycline. All were susceptible to clindamycin and ampicillin-sulbactam.
authors.affiliation: R. M. Alden Research Laboratory, Santa Monica-University of California Los Angeles Medical Center, 90404, USA. EJCGMD@aol.com
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: C Vreni
authors.initials: CV
authors.lastname: Merriam
authors.forename: Yumi A
authors.initials: YA
authors.lastname: Warren
authors.forename: Kerin L
authors.initials: KL
authors.lastname: Tyrrell
authors.forename: Helen T
authors.initials: HT
authors.lastname: Fernandez
mesh_terms: D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones; D006194:Gardnerella vaginalis / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D024841:Fluoroquinolones; D007211:Indoles; D015363:Quinolones; C419689:garenoxacin