Treatment of heart failure with autologous skeletal myoblasts.
BACKGROUND
The management of patients with heart failure is a daily challenge for cardiologists and cardiac surgeons. Pharmacotherapy, atrio-biventricular resynchronization, myocardial revascularization, valve repair techniques, latissimus dorsi cardiomyopathy, acorn cardiac support device, heart transplantation and mechanical assist devices do not cover all the needs. The recent progress in cellular and molecular biology allows the development of new therapies for heart failure.
One of the most innovative consists in the transplantation of autologous ex-vivo expanded cells into the myocardium for heart muscle regeneration. This approach is called "cellular cardiomyoblasty".
Chachques
Juan C
JC
Department of Cardiac Surgery, Pompidou and Broussais Hospitals, University of Paris, France. j.chachques@brs.ap-hop-paris.fr
Cattadori
Barbara
B
Herreros
Jesus
J
Prosper
Felipe
F
Trainini
Jorge C
JC
Blanchard
Didier
D
Fabiani
Jean-Noël
JN
Carpentier
Alain
A
D000818:Animals; D001706:Biopsy; D002304:Cardiac Pacing, Artificial; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology / Q000601:surgery*; D018421:Cardiomyoplasty / Q000379:methods*; D002469:Cell Separation; D002470:Cell Survival; D002478:Cells, Cultured; D003470:Culture Media; D004452:Echocardiography; D015150:Echocardiography, Doppler; D016228:Endothelial Growth Factors / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D008222:Lymphokines / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000166:cytology; D032448:Myoblasts, Skeletal / Q000637:transplantation*; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000503:physiopathology / Q000601:surgery*; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000601:surgery*; D012038:Regeneration; D012756:Sheep; D013318:Stroke Volume; D013997:Time Factors; D014182:Transplantation, Autologous; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D018487:Ventricular Dysfunction, Left
D003470:Culture Media; D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors