Regulation of angiogenesis by the hemostatic system.
In recent years it has become apparent that the hemostatic system has a role to play in regulating angiogenesis. This is achieved by components of the coagulation and fibrinolytic systems regulating proteolysis in the milieu and context of extra cellular matrix and the fibrin clot. It is also an emerging paradigm that cryptic fragments, released by proteolysis from components of the coagulation and fibrinolytic systems, have a role to play in regulating angiogenesis. Presented herein is a brief overview of the regulation of angiogenesis by the hemostatic system.
Pirie-Shepherd
Steven R
SR
Attenuon LLC, 10130 Sorrento Valley Road, San Diego CA 92121, USA. shepherd@attenuon.com
D000818:Animals; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*