title: Improving the prediction of outcome in severe acute closed head injury by using discriminant function analysis of normal auditory brainstem response latencies and amplitudes.
abstract: OBJECTIVE
  The auditory brainstem response (ABR) is a useful addition to standard medical measures for predicting outcome in patients with severe acute closed head injury (ACHI). Limiting this success, however, is the poor predictive value of a so-called "normal" ABR. In this study the authors used discriminant function analysis (DFA) of ABR Wave I, III, and V latencies and amplitudes to improve the predictive accuracy of the normal ABR, both as a single measure and in combination with other standard medical measures.
  
  
  METHODS
  The DFAs were conducted using the ABR and medical results in 68 patients with severe ACHI (30 who died [ACHI-died], and 38 who survived [ACHI-lived]) who presented with normal ABR responses in the neurosurgical intensive care unit of the authors' hospital in Johannesburg. All patients had undergone surgery to remove an intracranial hematoma. Correct predictions of outcome by ABR DFA measures were 83% for the ACHI-died group (48% at > or = 90% confidence level) and 87% for the ACHI-lived group (71% at > or = 90% confidence level); by medical DFA measures the correct predictions were 83% for the ACHI-died group (96% at >; or = 90% confidence level) and 95% for the ACHI-lived group (94% at > or = 90% confidence level); and by combined ABR and medical DFA measures correct predictions were 100% for the ACHI-died group (100% at > or = 90% confidence level) and 97% for the ACHI-lived group (100% at > or = 90% confidence level).
  
  
  CONCLUSIONS
  The DFA of ABR Wave I, III, and V latencies and amplitudes improved the predictive ability of normal ABR results to rates similar to those obtained using DFA for the medical measures, although at lower confidence levels. The DFA of the combined ABR and medical measures improved correct predictions to rates significantly higher than for either of the measures on its own.
authors.affiliation: Department of Speech Pathology and Audiology, University of the Witwatersrand, Johannesburg, South Africa. w.wilson@shrs.uq.edu.au
authors.forename: Wayne J
authors.initials: WJ
authors.lastname: Wilson
authors.forename: Claire
authors.initials: C
authors.lastname: Penn
authors.forename: David
authors.initials: D
authors.lastname: Saffer
authors.forename: Farzin
authors.initials: F
authors.lastname: Aghdasi
mesh_terms: D000208:Acute Disease; D000328:Adult; D006259:Craniocerebral Trauma / Q000503:physiopathology*; D016002:Discriminant Analysis; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011930:Reaction Time; D012016:Reference Values; D015599:Trauma Severity Indices; D016896:Treatment Outcome