title: High concentrations of nelfinavir as an independent risk factor for lipodystrophy in human immunodeficiency virus-infected patients.
abstract: To assess the relationship between antiretroviral drug exposure and lipodystrophy, 69 human immunodeficiency virus type 1-infected patients receiving nelfinavir were investigated cross-sectionally. Lipodystrophy was defined by patients' self-report. Nelfinavir trough concentrations in plasma were significantly related to overall lipodystrophy and peripheral fat wasting scores and appeared to be an independent risk factor for lipodystrophy
authors.affiliation: Pharmacologie Périnatale et Pédiatrique, Groupe Hospitalier Cochin-Saint Vincent de Paul (AP-HP), Université René Descartes, 75674 Paris Cedex 14, France. jm.treluyer@svp.ap-hop-paris.fr
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Tréluyer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Morini
authors.forename: Jérome
authors.initials: J
authors.lastname: Dimet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gorin
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Rey
authors.forename: Jean
authors.initials: J
authors.lastname: Deleuze
authors.forename: Pierre-François
authors.initials: PF
authors.lastname: Ceccaldi
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Escande
authors.forename: Gérard
authors.initials: G
authors.lastname: Pons
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupin
mesh_terms: D001823:Body Composition; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D015497:HIV-1; D006801:Humans; D008060:Lipodystrophy / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D019888:Nelfinavir / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D017320:HIV Protease Inhibitors; D019888:Nelfinavir