title: Reliability of fine-needle aspiration biopsy in the initial diagnosis of soft-tissue lesions.
abstract: We retrospectively reviewed fine-needle aspiration biopsy (FNAB) specimens of 301 soft tissue lesions of the extremities and trunk. Final diagnoses were 137 benign and 86 malignant neoplasms and 78 nonneoplastic lesions. Of the 301 FNAB samples, 279 (93%) were adequate for cytologic diagnosis. The adequate FNAB specimens were initially grouped into three broad categories: benign (197 cases), malignant (57 cases), and suspicious for malignancy (25 cases). Sensitivity and specificity for diagnosis of a malignant lesion were 92% and 97%, respectively. The specimens were cytomorphologically classified into nine categories: small round (14 cases), spindle cell (77 cases), epithelioid/polygonal (16 cases), pleomorphic (29 cases), myxoid (19 cases), lipomatous (37 cases), epithelial (23 cases), inflammatory lesions (28 cases), and others (36 cases). Specific FNAB diagnoses were correct in 151 of 279 cases (54%) in combination with clinical and radiologic findings. FNAB is a valuable technique for the primary diagnosis of soft-tissue lesions.
authors.affiliation: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Nagira
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akisue
authors.forename: Takashi
authors.initials: T
authors.lastname: Marui
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hitora
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kurosaka
authors.forename: Chiho
authors.initials: C
authors.lastname: Ohbayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D005121:Extremities; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000473:pathology*