Current status of estrogen receptors.
Increasing knowledge on structure and function of estrogen receptors is providing information on the mechanism of action of estrogen agonists, as well as antagonists, and in understanding their tissue-selective action. However, there are still many factors associated with estrogen response which are poorly understood. Therefore, the task of designing a tissue-selective estrogen for use as a pharmaceutical in estrogen-dependent disorders remains an uncertain game. This review provides information on the current status of estrogen receptors for a better understanding.
Ray
Suprabhat
S
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. sraycdri@yahoo.com
Rastogi
Reema
R
Kumar
Atul
A
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D004965:Estrogen Antagonists / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy / Q000379:methods; D006801:Humans; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
D004965:Estrogen Antagonists; D011960:Receptors, Estrogen