Hypohidrotic ectodermal dysplasia associated with squamous cell carcinoma of the trachea.
Hypohidrotic ectodermal dysplasia (HED) is a rare condition characterized by abnormalities to ectodermal derived tissues although other organs or systems are frequently involved. Patients with HED can have a number of symptoms that may lead them to present to the otolaryngologist. We present a case of a 37-year-old female with HED who initially presented with nasal obstruction but then very rapidly developed stridor due to a tracheal squamous cell carcinoma. We suggest a possible association between HED and carcinoma of the upper respiratory tract that has not previously been reported.
Winter
S C A
SC
Department of Otolaryngology, Radcliffe Infirmary, Oxford, UK.
Bates
G J
GJ
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D004476:Ectodermal Dysplasia / Q000150:complications*; D005260:Female; D005931:Glottis; D006801:Humans; D007007:Hypohidrosis / Q000150:complications*; D007829:Laryngostenosis / Q000209:etiology; D008279:Magnetic Resonance Imaging / Q000379:methods; D014134:Tracheal Neoplasms / Q000150:complications*