Superoxide dismutase activity and electrochemical study of the binuclear [Cu(TSA)2py]2 complex.
The superoxide dismutase-mimetic activity and the electrochemical behavior of the binuclear complex [Cu(TSA)2py]2 is reported. The complex exhibits a marked SOD activity in the nitroblue tetrazolium assay. Its redox response is in agrement with two copper atoms partially coupled through the carboxylate moieties. The electrode reactions lie in the range of the superoxide/peroxide and oxygen/superoxide couples. This fact is indicative that this complex can act as catalyst for the SOD reaction.
Parajón Costa
Beatriz Susana
BS
Centro de Química Inorgánica, Facultad de Ciencias Exactas, UNLP, La Plata, Argentina.
Tótaro
Roxana Maria
RM
Ferrer
Evelina Gloria
EG
Williams
Patricia Ana Maria
PA
D000818:Animals; D002384:Catalysis; D002417:Cattle; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D004563:Electrochemistry; D004912:Erythrocytes / Q000201:enzymology; D007202:Indicators and Reagents / Q000494:pharmacology; D008956:Models, Chemical; D009580:Nitroblue Tetrazolium / Q000494:pharmacology; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D012459:Salicylates / Q000378:metabolism; D013438:Sulfhydryl Compounds; D013482:Superoxide Dismutase / Q000378:metabolism*; D013816:Thermodynamics
D007202:Indicators and Reagents; D009942:Organometallic Compounds; D012459:Salicylates; D013438:Sulfhydryl Compounds; D009580:Nitroblue Tetrazolium; D003300:Copper; C441201:thiosalicylic acid; D013482:Superoxide Dismutase; D010100:Oxygen