Endophenazines A-D, new phenazine antibiotics from the athropod associated endosymbiont Streptomyces anulatus II. Structure elucidation.
A detailed screening of the secondary metabolite pattern produced by different athropod associated strains of the species Streptomyces anulatus resulted in the isolation and structure elucidation of the endophenazines A-D (2, 4-6). The structures were assigned by spectroscopic methods and chemical transformations. 4 represents a chromophoric system based on a phenazin-7-one, 5 and 6 are new 5,10-dihydrophenazine derivatives.
Krastel
Philipp
P
Institut für Organische Chemie, Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Zeeck
Axel
A
Gebhardt
Klaus
K
Fiedler
Hans-Peter
HP
Rheinheimer
Joachim
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001181:Arthropods / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D010619:Phenazines / Q000737:chemistry*; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010619:Phenazines; C469530:endophenazine A; C469531:endophenazine B; C469532:endophenazine C; C469529:endophenazine D