title: [The progress in research on changes of central venous pressure under simulated weightlessness and microgravity].
abstract: One of the most profound circulatory changes that occur in man during exposure to microgravity is a cephalad redistribution of fluid. Central venous pressure (CVP) is not only an important standard for determining the cephalad redistribution of fluid but also the unique valuable means for measuring continuously cardiac filling pressure under simulated weightlessness (SW) and microgravity, and has a relationship with neurohumoral [correction of nerohumoral] regulation. With the development of manned spaceflight, the researches in space suggested that CVP did not increase, which is directly contradictory to the previous results under SW. This paper mainly discusses the changes of CVP and the effects of countermeasures on CVP under SW and microgravity, and the mechanisms of decreased CVP under microgravity. It is postulated that more suitable SW models, more studies about the area of low pressure including especially pulmonary circulation, and comprehensive studies in multiple systems are needed.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, China.
authors.forename: D S
authors.initials: DS
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: Q L
authors.initials: QL
authors.lastname: Xiang
authors.forename: W
authors.initials: W
authors.lastname: Ren
mesh_terms: D018493:Cardiovascular Deconditioning; D002496:Central Venous Pressure / Q000502:physiology*; D018495:Fluid Shifts / Q000502:physiology*; D006801:Humans; D011652:Pulmonary Circulation / Q000502:physiology*; D013026:Space Flight; D014893:Weightlessness; D018544:Weightlessness Countermeasures; D018474:Weightlessness Simulation