title: Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients.
abstract: OBJECTIVE
  This study evaluated the effect of statin therapy on mortality in individuals with significant coronary artery disease (CAD) stratified by age.
  
  
  BACKGROUND
  Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) significantly reduce morbidity and mortality in individuals with CAD. Unfortunately, the large statin trials excluded individuals over 80 years old, and it is therefore unknown whether very elderly individuals benefit from statins as do younger individuals.
  
  
  METHODS
  A cohort of 7,220 individuals with angiographically defined significant CAD (> or =70%) was included. Statin prescription was determined at hospital discharge. Patients were followed up for 3.3 +/- 1.8 years (maximum 6.8). Patients were grouped by age (<65, 65 to 79, and > or =80 years) to determine whether statin therapy reduced mortality in an age-dependent manner.
  
  
  RESULTS
  Average age was 65 +/- 12 years; 74% were male; and 31% had a postmyocardial infarction status. Overall mortality was 16%. Elderly patients were significantly less likely to receive statins than younger patients (> or =80 years: 19.8%; 65 to 79 years: 21.1%; <65 years: 28.0%; p < 0.001). Mortality was decreased among statin recipients in all age groups: > or =80 years: 29.5% among patients not taking a statin versus 8.5% of those taking a statin (adjusted hazard ratio [HR] 0.50, p = 0.036); 65 to 79 years: 18.7% vs. 6.0% (HR 0.56, p < 0.001); and <65 years: 8.9% vs. 3.1% (HR 0.70, p = 0.097).
  
  
  CONCLUSIONS
  Statin therapy is associated with reduced mortality in all age groups of individuals with significant CAD, including very elderly individuals. Although older patients were less likely to receive statin therapy, they received a greater absolute risk reduction than younger individuals. More aggressive statin use after CAD diagnosis may be indicated, even in older patients.
authors.affiliation: Cardiology Research, LDS Hospital, 8th Avenue & C Street, Salt Lake City, Utah 84143, USA.
authors.forename: Chloe A
authors.initials: CA
authors.lastname: Allen Maycock
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Muhlestein
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Horne
authors.forename: John F
authors.initials: JF
authors.lastname: Carlquist
authors.forename: Tami L
authors.initials: TL
authors.lastname: Bair
authors.forename: Robert R
authors.initials: RR
authors.lastname: Pearson
authors.forename: Qunyu
authors.initials: Q
authors.lastname: Li
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003327:Coronary Disease / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors