Identification of Staphylococcus xylosus isolated from C57BL/6J-Nos2(tm1Lau) mice with dermatitis.
Coagulase negative staphylococci (CNS) are significant pathogens, particularly in medical device related infections and in immunocompromised patients. Five CNS strains were isolated from 5 NOS2 knockout mice with dermatitis. Histologically, granulomatous dermatitis was found in the skin around the ear with epidermal ulceration. Dermal lesions included pustules, necrosis, and accumulations of neutrophils and macrophages. Isolates of the bacterial strains were identified to be Staphylococcus xylosus by the API STAPH kit and 16S-23S intergenic transcribed spacer-PCR. These results demonstrate the potential of this organism to be an opportunistic pathogen in immunocompromised mice.
Won
Young Suk
YS
Department of Microbiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Korea.
Kwon
Hyo Jung
HJ
Oh
Goo Taeg
GT
Kim
Bang Hyun
BH
Lee
Chul Ho
CH
Park
Yong Ho
YH
Hyun
Byung Hwa
BH
Choi
Yang Kyu
YK
D000818:Animals; D003030:Coagulase / Q000378:metabolism; D003872:Dermatitis / Q000382:microbiology* / Q000473:pathology; D006651:Histocytochemistry / Q000379:methods; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D009894:Opportunistic Infections / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000032:analysis; D012338:RNA, Ribosomal, 23S / Q000032:analysis; D013207:Staphylococcal Skin Infections / Q000382:microbiology* / Q000473:pathology; D013210:Staphylococcus / Q000145:classification / Q000302:isolation & purification*
D003030:Coagulase; D012336:RNA, Ribosomal, 16S; D012338:RNA, Ribosomal, 23S; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse