Synthesis of (+)-Lasonolide A: (-)-lasonolide A is the biologically active enantiomer.
(+)-Lasonolide A was synthesized following the established procedure. (-)-Lasonolide A was found to be the biologically active enantiomer.
Lee
Eun
E
School of Chemistry and Molecular Engineering, Seoul National University, Republic of Korea. eunlee@snu.ac.kr
Song
Ho Young
HY
Joo
Jung Min
JM
Kang
Jung Won
JW
Kim
Dae Shik
DS
Jung
Cheol Kyu
CK
Hong
Chang Yong
CY
Jeong
ShinWu
S
Jeon
Kiwan
K
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009904:Optical Rotation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018942:Macrolides; C450700:lasonolide A