[Effects of Qiang Gu Kang Wei compound on hemorheology in tail-suspended rats].
Objective. To investigate the effects of Qiang Gu Kang Wei compound on hemorheology in tail-suspended rats. Method. Rats were tail-suspended (-30 degrees) for 21 d to simulate weightlessness. The effect of the compound on erythrocyte sedimentation rate (ESR), hematocrit value (HCT), plasma fibrinogen content (PFC), blood viscosity, red blood cells deformability and erythrocytes aggregation were examined. Result. PFC, whole blood reducing viscosity (eta h), whole blood viscosity (eta b), erythrocyte rigid index (IR) and maximum aggregation index (MAXD) increased significantly (P<0.01 or P<0.05 ) and maximum deformity index (DImax) (P<0.01) decreased significantly in suspended rats as compared with the normal control. Different doses of the compound showed different effects. The small dose group (10 g/kg) inhabited eta h and eta b (P<0.01 or P<0.05) of all shear rates, abnormal IR and MAXD (P<0.01); The middle dose group (20 g/kg) decreased PFC (P<0.01); The big dose group (30 g/kg) inhabited eta h and eta b (P<0.01 or P<0.05) of high shear rates, decreased IR (P<0.01), and improved DImax (P<0.01). Conclusion. This compound could improve hemorheology in tail-suspended rats. But there was no concentration-dependence.
Li
Yong-zhi
YZ
Institute of Space Medico-Engineering, Beijing, China.
Shi
Hong-zhi
HZ
Fan
Quan-chun
QC
Bai
Gui-e
GE
Duan
Yuan-ru
YR
Xie
Jun-shui
JS
D000818:Animals; D001799:Blood Sedimentation / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005340:Fibrinogen / Q000187:drug effects; D006400:Hematocrit; D018056:Hemorheology / Q000187:drug effects*; D019417:Hindlimb Suspension; D051381:Rats; D017207:Rats, Sprague-Dawley; D018474:Weightlessness Simulation / Q000009:adverse effects*
D004365:Drugs, Chinese Herbal; D005340:Fibrinogen