title: Evaluation of the UMLS as a terminology and knowledge resource for biomedical informatics.
abstract: OBJECTIVE
  Terminology and knowledge resources are essential components of interoperability among disparate systems. This paper evaluates whether names and relationships needed in biomedical informatics are present in the UMLS.
  
  
  METHODS
  Terms for five broad categories of concepts were extracted from LocusLink and mapped to the UMLS Metathesausus. Relationships between gene products and the other four categories (phenotype, molecular function, biological process, and cellular component) were searched for in the Metathesaurus. All gene products in the Gene Ontology database were also mapped to the UMLS in order to evaluate its global coverage of the domain.
  
  
  RESULTS
  The coverage of concepts ranged from 2% (gene product symbols) to 44% (molecular functions). The coverage of relationships ranged from 60% for Gene product-Biological process to 83% for Gene product-Molecular function.
  
  
  CONCLUSIONS
  Terminology and ontology issues are discussed, as well as the need for integrating additional resources to the UMLS.
authors.affiliation: National Library of Medicine, Bethesda, MD, USA. [olivier|mitchell|mccray]@nlm.nih.gov
authors.forename: Olivier
authors.initials: O
authors.lastname: Bodenreider
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Mitchell
authors.forename: Alexa T
authors.initials: AT
authors.lastname: McCray
mesh_terms: D030541:Databases, Genetic; D008490:Medical Informatics; D011506:Proteins / Q000235:genetics*; D009626:Terminology as Topic; D017432:Unified Medical Language System
chemical_list: D011506:Proteins