title: Perfusion and ventilation isotope lung scans in constrictive bronchiolitis obliterans. A series of three cases.
abstract: Constrictive bronchiolitis obliterans (BO) has been defined as a syndrome of airflow limitation due to bronchiolar and peribronchiolar inflammation and fibrosis. However, chest roentgenograms are frequently normal, and alternative radiographic evaluation or other manifestations of the disease would be required. Here we report three patients with BO. We performed a technetium-99(m)-labeled macroaggregate human albumin lung perfusion scan and a ventilation scan using krypton-81(m). We observed multiple matched defects in the perfusion and ventilation scans in these patients, which represent narrowing or obliteration of the bronchiolar lumen and its adjacent pulmonary arteriole. We propose that this is a useful diagnostic approach for an imaging study of BO.
authors.affiliation: First Department of Internal Medicine, Clinical Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan. yhasega@med.nagoya-u.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Imaizumi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sekido
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Iinuma
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kawabe
authors.forename: Naozumi
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Kaoru
authors.initials: K
authors.lastname: Shimokata
mesh_terms: D000328:Adult; D001989:Bronchiolitis Obliterans / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007727:Krypton Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012129:Respiratory Function Tests; D013668:Technetium Tc 99m Aggregated Albumin; D014692:Ventilation-Perfusion Ratio
chemical_list: D007727:Krypton Radioisotopes; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin