Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes.
Five fatty acid derivatives including three novel compounds were isolated from the mushroom Clitocybe clavipe. Their structures were elucidated by spectral analyses. These compounds inhibited aldehyde dehydrogenase in vitro.
Kawagishi
Hirokazu
H
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422-8529, Japan. achkawa@agr.shizuoka.ac.jp
Miyazawa
Toshiyuki
T
Kume
Hiroko
H
Arimoto
Yasushi
Y
Inakuma
Takahiro
T
D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D001487:Basidiomycota / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D007564:Japan; D008049:Lipase / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000201:enzymology
D004791:Enzyme Inhibitors; D005227:Fatty Acids; D000444:Aldehyde Dehydrogenase; D008049:Lipase