title: Apoptotic pathways: involvement of lysosomal proteases.
abstract: Apoptosis or programmed cell death is the major mechanism used by multicellular organisms to remove infected, excessive and potentially dangerous cells. Cysteine proteases from the caspase family play a crucial role in the process. However, there is increasing evidence that lysosomal proteases are also involved in apoptosis. In this review various lysosomal proteases and their potential contribution to propagation of apoptosis are discussed.
authors.affiliation: Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia.
authors.forename: Boris
authors.initials: B
authors.lastname: Turk
authors.forename: Veronica
authors.initials: V
authors.lastname: Stoka
authors.forename: Jerica
authors.initials: J
authors.lastname: Rozman-Pungercar
authors.forename: Tina
authors.initials: T
authors.lastname: Cirman
authors.forename: Gabriela
authors.initials: G
authors.lastname: Droga-Mazovec
authors.forename: Kristina
authors.initials: K
authors.lastname: Oresić
authors.forename: Vito
authors.initials: V
authors.lastname: Turk
mesh_terms: D000818:Animals; D017209:Apoptosis; D010450:Endopeptidases / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; C018589:lysosomal proteins; D010450:Endopeptidases