A tumor lysis-like syndrome during therapy of visceral leishmaniasis.
Reported herein for the first time in the literature is the case of a 41-yr-old woman who developed a tumor lysis-like syndrome, consisting of hyperkalemia, hyperphosphatemia, hyperuricemia, and acute renal insufficiency, soon after the initiation of chemotherapy for severe visceral leishmaniasis with liposomal amphotericin B. Allopurinol therapy, together with iv fluid administration and urine alkalization, resulted in full recovery of the metabolic abnormalities. Awareness of this condition can lead to prophylactic treatment as well as the early recognition and management of susceptible patients.
Liberopoulos
Evagelos
E
Department of Internal Medicine, University of Ioannina, Ioannina, Greece. egepi@cc.uoi.gr
Alexandridis
George
G
Elisaf
Moses
M
D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use; D000666:Amphotericin B / Q000009:adverse effects*; D000963:Antimetabolites / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D015275:Tumor Lysis Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D014556:Urine / Q000737:chemistry
D000963:Antimetabolites; D000981:Antiprotozoal Agents; D000493:Allopurinol; D000666:Amphotericin B