title: The effect of probucol on atherosclerosis in streptozotocin-induced diabetic-hyperlipidemic APA hamsters in different stages of atherosclerosis.
abstract: We investigated the effect of probucol (PB) on atherosclerosis in streptozotocin (SZ)-induced diabetic-hyperlipidemic APA hamsters in three different stages, the early, middle and late stages of atherosclerosis. Male APA hamsters were injected intraperitoneally with SZ or vehicle alone (citrate buffer; CB) as a control at the age of 8 weeks. At 6 weeks after injection (WAI) of SZ or CB (the early stage), 14 WAI (the middle stage) and 26 WAI (the late stage), animals were assigned to PB treated- or non-treated groups (CBPB, SZPB, CB, SZ). After 8 weeks of PB administration with diet, the aorta was taken from each animal for assessment of atheromatous lesions and blood samples were subjected to serum biochemical analysis and the measurement of blood lipid peroxide (LPO). In the middle stage, PB treatment significantly decreased serum total cholesterol level, slightly decreased LPO, and also tended to reduce the lesion area, although no statistical difference was seen. There was no marked effect of PB treatment in the early and late stages. These findings suggest that single use of PB has little effect on atherosclerosis of a hyperglycemia-hyperlipidemia animal model.
authors.affiliation: Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Horiuchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takatori
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Inenaga
authors.forename: Etsuko
authors.initials: E
authors.lastname: Ohta
authors.forename: Jun
authors.initials: J
authors.lastname: Yamanouchi
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawamura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ishii
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kyuwa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications*; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D011341:Probucol / Q000008:administration & dosage*
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D008054:Lipid Peroxides; D002784:Cholesterol; D011341:Probucol