title: High rate of monoclonal gammopathy among immunocompetent subjects with primary cytomegalovirus infection.
abstract: Serum samples from immunocompetent adults with primary cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infection and from solid-organ or bone marrow transplant recipients with primary CMV infection were examined for paraproteins. Several immunocompetent patients with CMV infection but none with EBV infection presented with an M component, which implies that the M component connects CMV infection to a risk of B cell malignancy.
authors.affiliation: Department of Virology, Helsinki University Central Hospital, FIN-00029 HUCH, Helsinki, Finland. suvi.buhler@hus.fi
authors.forename: Suvi
authors.initials: S
authors.lastname: Bühler
authors.forename: Kalevi
authors.initials: K
authors.lastname: Laitinen
authors.forename: Harry
authors.initials: H
authors.lastname: Holthöfer
authors.forename: Asko
authors.initials: A
authors.lastname: Järvinen
authors.forename: Knut-Olof
authors.initials: KO
authors.lastname: Schauman
authors.forename: Klaus
authors.initials: K
authors.lastname: Hedman
mesh_terms: D000293:Adolescent; D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009194:Myeloma Proteins / Q000032:analysis; D010265:Paraproteinemias / Q000209:etiology / Q000276:immunology* / Q000378:metabolism
chemical_list: D007075:Immunoglobulin M; D009194:Myeloma Proteins