title: Adult primary teratoma of the testis--report on 5 cases in clinical stage I disease.
abstract: OBJECTIVE
  Testis pure teratoma accounts for 2.7% to 3% of all germ cell tumors in adult where it behaves as a malignant neoplasm. Pure teratoma of the testis presents in clinical stage I disease in 44% of the patients whose risk of having pathological stage II disease is 16.7% to 19.2%. Herein we report on 5 cases of adult pure teratoma of the testis presenting itself in clinical stage I disease.
  
  
  METHODS
  From September 1976 to February 2000, 75 patients underwent orchidectomy for clinical stage I nonseminomatous germ cell cancer of the testis. Testis pure teratoma was detected in 5 patients (7%). Testis tumor markers were evaluated in all cases. Patients underwent imaging examination to detect the clinical stage of the disease. Treatment options after orchidectomy included retroperitoneal lymph node dissection (RPLND) in 4 patients and surveillance in 1.
  
  
  RESULTS
  The average age of the patients was 31 years (range 24-45). The tumor was on the left sided in 3 cases (60%) and right in 2 (40%). Tumor average size was 3.2 cm (rang 1-6). Histopathology detected the following subtypes: mature teratoma in 3 cases (60%), immature teratoma in 1 (20%) and teratoma with malignant transformation in (20%). All patients were at clinical stage I disease. Germ cell cancer microscopic metastatic disease including embryonal carcinoma was detected in I dissected lymph node of 1/4 patients (25%). Average follow up was 166 months (range 93-249). All patients were alive and disease free and no relapses were detected during the follow up period.
  
  
  CONCLUSIONS
  Primary pure teratoma of the testis does not respond to chemotherapy nor does it to radiation therapy. The disease treatment options after orchidectomy for patients with clinical stage I disease include RPLND or surveillance with their relative risks and benefits. RPLND is the chosen treatment because it is both staging and treating. A close a long term follow up is required since pure teratoma metastatic disease may clinically develop after more than 10 years.
authors.affiliation: Department of Urology, University Hospital, Verona, Italy. drporcaro@yahoo.com
authors.forename: A B
authors.initials: AB
authors.lastname: Porcaro
authors.forename: S Z
authors.initials: SZ
authors.lastname: Antoniolli
authors.forename: G
authors.initials: G
authors.lastname: Martignoni
authors.forename: M
authors.initials: M
authors.lastname: Brunelli
authors.forename: P
authors.initials: P
authors.lastname: Curti
mesh_terms: D000328:Adult; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D013724:Teratoma / Q000473:pathology / Q000601:surgery*; D013736:Testicular Neoplasms / Q000473:pathology / Q000601:surgery*