Survival of Ugandan infants with subtype A and D HIV-1 infection (HIVNET 012).
Virologic factors may influence survival of HIV-1-infected infants. We compared survival of Ugandan infants with subtype A and subtype D HIV-1 infection. This study was performed in the context of the Ugandan clinical trial HIVNET 012, which compared the efficacy of single-dose nevirapine (NVP) and short-course zidovudine (AZT) for prevention of HIV-1 mother-to-child transmission. HIV-1 subtypes were determined by phylogenetic analysis of HIV-1 protease and reverse transcriptase sequences from 32 women in the NVP arm and 54 women in the AZT arm of HIVNET 012 whose infants were HIV-1 infected by 6 to 8 weeks of age. We found no association between HIV-1 subtype (A vs. D) and infant survival in this cohort. Further studies are needed to evaluate whether HIV-1 subtype influences clinical outcome in pediatric HIV-1 infection.
Eshleman
Susan H
SH
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA. seshlem@jhmi.edu
Guay
Laura A
LA
Fleming
Thomas
T
Mwatha
Anthony
A
Mracna
Martin
M
Becker-Pergola
Graziella
G
Musoke
Philippa
P
Mmiro
Francis
F
Jackson
J Brooks
JB
D015331:Cohort Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000401:mortality* / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008969:Molecular Sequence Data; D019829:Nevirapine / Q000627:therapeutic use; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D015996:Survival Rate; D014454:Uganda / Q000453:epidemiology; D015215:Zidovudine / Q000627:therapeutic use
D015215:Zidovudine; D019829:Nevirapine