title: Resistance to macrolides in Group A streptococci from the European section of Turkey: genetic and phenotypic characterization.
abstract: The aim of this study was to determine the susceptibilities to macrolides of Group A streptococcal isolates from the European section of Turkey. In the case of resistant isolates, the patterns and genetic mechanisms of erythromycin resistance were studied. Seven (2.7%) of the 260 isolates were resistant to erythromycin. Four of them showed the M phenotype and harboured mefA genes whereas three isolates showed the inducible macrolide, lincosamide and streptogramin B resistance phenotype and harboured ermTR genes. In the European section of Turkey, the current resistance rate of Group A streptococci to macrolides remains low.
authors.affiliation: Department of Clinical Bacteriology and Infectious Diseases, Medical Faculty of Trakya University, 22030 Edirne, Turkey. mikro@trakya.edu.tr
authors.forename: Filiz
authors.initials: F
authors.lastname: Akata
authors.forename: Devrim
authors.initials: D
authors.lastname: Oztürk
authors.forename: Ozlem
authors.initials: O
authors.lastname: Tansel
authors.forename: Müserref
authors.initials: M
authors.lastname: Tatman-Otkun
authors.forename: Metin
authors.initials: M
authors.lastname: Otkun
authors.forename: Frederic
authors.initials: F
authors.lastname: Fitoussi
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Murat
authors.initials: M
authors.lastname: Tugrul
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology*; D005060:Europe / Q000208:ethnology; D006801:Humans; D008826:Microbial Sensitivity Tests; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics*; D014421:Turkey
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin