Cytogenetic mapping of five YAC clones to human chromosome region 2q31 --> q32.1 in relation to the FRA2G common fragile site.
In this work, five YAC clones have been mapped by fluorescent in situ hybridization (FISH) to human chromosome region 2q31 --> q32.1 and ordered in relation to each other and to the FRA2G common fragile site. YAC clones that span the fragile site have been identified. Moreover a deleted HOXD 13 gene has been identified on the 942D2 YAC.
Pelliccia
Franca
F
Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, Roma, Italy.
Limongi
Maria Zaira
MZ
Gaddini
Lucia
L
Russo
Maria Teresa
MT
Rocchi
Angela
A
D002478:Cells, Cultured; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000235:genetics*; D051921:Fos-Related Antigen-2; D017353:Gene Deletion; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000097:blood / Q000378:metabolism; D020161:Physical Chromosome Mapping; D010835:Phytohemagglutinins / Q000494:pharmacology; D016133:Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics*
D017931:DNA Primers; D015342:DNA Probes; D004268:DNA-Binding Proteins; C497872:FOSL2 protein, human; D051921:Fos-Related Antigen-2; C513184:HOXD13 protein, human; D018398:Homeodomain Proteins; D010835:Phytohemagglutinins; D014157:Transcription Factors