title: Hyperhomocyst(e)inemia: a risk factor for cerebrovascular disease.
abstract: Many case-control and cohort studies have identified a strong, independent and dose-related association between moderate hyperhomocyst(e)inemia and atherosclerotic vascular disease, with respect to the pathogenetic link between hyperhomocyst(e)inemia and stroke, the possible role in inducing an endothelial wall damage deserves special attention. Some prospective cohort studies have failed to demonstrate a positive association between elevated homocyst(e)ine (Hcy) levels and stroke. Further studies are needed, in order to better characterize the association between Hcy concentrations and risk of stroke.
authors.affiliation: Neuroscience Department, University of Perugia, Italy. parnetti@unipg.it
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
authors.forename: Valeria
authors.initials: V
authors.lastname: Caso
authors.forename: Serena
authors.initials: S
authors.lastname: Amici
authors.forename: Alessia
authors.initials: A
authors.lastname: Lanari
authors.forename: Virgilio
authors.initials: V
authors.lastname: Gallai
authors.forename: Teodoro
authors.initials: T
authors.lastname: Bottiglieri
mesh_terms: D015415:Biomarkers / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D006710:Homocysteine