Involvement of nitric oxide on prolactin release induced by immobilization stress in rats.
The nitric oxide (NO) has important participation in the control of hypothalamic-pituitary axis. The authors investigated the effect of NO donor, isosorbide dinitrate (ISDN), on prolactin (PRL) release induced by immobilization stress (IS) in male rats. Pretreatment with the NO donor, ISDN (2.5; 5 and 10 mg/kg), inhibited about 60-85% of the PRL response to IS. It is concluded that NO does participate in the regulation of PRL response to IS.
Luras
Anderson
A
Department of Physiological Sciences, Federal University of São Carlos, Rod. Washington Luiz km 235, 13565-905, São Carlos, SP, Brazil.
Nonaka
Keico O
KO
D000818:Animals; D019540:Area Under Curve; D004305:Dose-Response Relationship, Drug; D007548:Isosorbide Dinitrate / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*
D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D011388:Prolactin; D007548:Isosorbide Dinitrate