Chlorotrimethylsilane: a suitable reagent for the synthesis of chlorohydrin esters.
A new methodology for obtaining chlorohydrin esters using a one-pot esterification-chlorination reaction, in which one of the reagents, chlorotrimethylsilane, acts as solvent, is described. The reaction is stereospecific and its regioselectivity depends on the number of carbons between the hydroxyl groups present in the starting material. A mechanism is proposed.
Eras
Jordi
J
Chemistry Department and Centre UdL-IRTA, Universitat de Lleida, Rovira Roure 191, 25198 Lleida, Spain.
Méndez
Jonh Jairo
JJ
Balcells
Mercè
M
Canela
Ramon
R