Specificity in signaling by c-Yes.
c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases, there is also a growing body of evidence to indicate specificity in signaling. In this review, we summarize c-Yes, its potential functions and its ability to modulate signals that are distinct from c-Src.
Summy
Justin M
JM
Dept. of Microbiology and Immunology and Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown WV 26506-9300, USA.
Sudol
Marius
M
Eck
Michael J
MJ
Monteiro
Alvaro N
AN
Gatesman
Amanda
A
Flynn
Daniel C
DC
D000818:Animals; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051575:Proto-Oncogene Proteins c-yes; D015398:Signal Transduction / Q000502:physiology*; D013379:Substrate Specificity; D019061:src-Family Kinases
D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D051575:Proto-Oncogene Proteins c-yes; D019061:src-Family Kinases