title: The capacity of glutathione reductase in cell protection from the toxic effect of heated oils.
abstract: This empirical study tries to focus on the evidence that the wrong use of oil in food cooking leads to health problems. High temperatures associated with the repeated use of the same oil lead to the breakdown of some fatty acids, forming numerous toxic polymer compounds and peroxides. The obtained data have showed that the ratios of polymer compounds reached 11.3% in oil heated continuously for 10 h at 220 degrees C, and 37.8% in frying oil (FO). Moreover, the polar compound ratios reached 25.6% and 47.6% in continuously heated oil (CHO) and FO, respectively. However, the peroxide concentrations were 157.1 and 133.6 mM/kg in CHOs and FOs, respectively. The observed results have allowed the study of the role of the glutathione redox system in the detoxification and elimination of different toxic peroxides resulting from heated oils. On a diet of 10% of CHO and FO, a significant increase in glutathione peroxidase (GPx) and glutathione reductase (GR) activities appears. This combined relationship between the decreased glutathione content and the increased GPx and GR activities in rats fed on CHO and FO confirms the participation of the glutathione redox system in the detoxifying reactions of continuously accumulated peroxides.
authors.affiliation: Department of Biochemistry, Faculty of Sciences, University of Annaba, Annaba 23000, Algeria. saskasadz.@yahoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Saka
authors.forename: W
authors.initials: W
authors.lastname: Aouacheri
authors.forename: C
authors.initials: C
authors.lastname: Abdennour
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000378:metabolism / Q000633:toxicity; D005978:Glutathione / Q000032:analysis / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism*; D006358:Hot Temperature; D008658:Inactivation, Metabolic; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D010938:Plant Oils / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D008054:Lipid Peroxides; D010938:Plant Oils; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione