title: Sorting out the cellular functions of sorting nexins.
abstract: Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.
authors.affiliation: Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA. cdworby@umich.edu
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Worby
authors.forename: Jack E
authors.initials: JE
authors.lastname: Dixon
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001692:Biological Transport / Q000502:physiology*; D002352:Carrier Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010743:Phospholipids / Q000378:metabolism; D010802:Phylogeny; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D033921:Vesicular Transport Proteins; D015003:Yeasts / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D010743:Phospholipids; D033921:Vesicular Transport Proteins