title: [Rapid analysis of biocompatibility with graded test samples exemplified by Ni-NiTi-Ti].
abstract: The biocompatibility of nickel-titanium alloys was investigated by single-culture experiments on functionally graded samples with a stepwise change in composition from nickel to titanium, including NiTi shape memory alloy of a 50:50 mixture. This approach permitted a considerable decrease of experimental resources by simultaneously studying a full variation of composition. The results indicate a good biocompatibility for a nickel content up to about 50%. The cells used in the biocompatibility studies comprised human osteoblast-like osteosarcoma cells (SAOS-2, MG-63), primary human osteoblasts (HOB), and murine fibroblasts (3T3).
authors.affiliation: Chirurgische Klinik und Poliklinik, BG Kliniken Bergmannsheil Bochum, Deutschland. denise.bogdanski@ruhr-uni-bochum.de
authors.forename: D
authors.initials: D
authors.lastname: Bogdanski
authors.forename: M
authors.initials: M
authors.lastname: Köller
authors.forename: M
authors.initials: M
authors.lastname: Bram
authors.forename: D
authors.initials: D
authors.lastname: Stöver
authors.forename: H P
authors.initials: HP
authors.lastname: Buchkremer
authors.forename: J
authors.initials: J
authors.lastname: Choi
authors.forename: M
authors.initials: M
authors.lastname: Epple
authors.forename: G
authors.initials: G
authors.lastname: Muhr
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005347:Fibroblasts; D006801:Humans; D008422:Materials Testing; D051379:Mice; D009532:Nickel / Q000009:adverse effects* / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology*; D012516:Osteosarcoma; D013329:Structure-Activity Relationship; D014025:Titanium / Q000009:adverse effects* / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: C040654:titanium nickelide; D009532:Nickel; D014025:Titanium