title: Reoperative mitral valve replacement: importance of preservation of the subvalvular apparatus.
abstract: BACKGROUND
  Preservation of the subvalvular apparatus has been demonstrated to be beneficial during first-time mitral valve replacement (MVR), but has not been fully examined in reoperative (redo) MVR. The purpose of this study was to analyze outcomes in a large cohort of redo MVR patients, focusing on the effect of subvalvular preservation on mortality.
  
  
  METHODS
  We undertook a review of prospectively gathered data on patients undergoing MVR, with or without concomitant cardiac procedures, at our institution from 1990 to 1999. Predictors of mortality were determined by stepwise logistic regression.
  
  
  RESULTS
  A total of 1,521 consecutive MVR patients were analyzed, of which, 513 (34%) had undergone one or more previous MV procedures. In-hospital mortality occurred in 6.9% of first-time MVR patients versus 9.0% in redo patients (p = 0.13). The number of prior MV operations ranged from one to five in redo MVR patients, with 115 patients (22% of redos) having two or more. In redo MVR patients, preservation of the native posterior subvalvular apparatus was performed in 103 patients (21%), whereas native anterior and posterior preservation was performed in 31 patients (6%). Gore-Tex neochordal construction was performed in 135 redo MVR patients (26%). Perioperative mortality occurred in 3.6% of redo MVR patients with a preserved subvalvular apparatus (native tissue and/or Gore-Tex reconstruction) versus 13.3% of redo patients without preservation (p < 0.001). Independent predictors of mortality in redo MVR patients were (in decreasing order of magnitude) failure to preserve the subvalvular apparatus, preoperative renal failure, previous stroke/transient ischemic attack, left ventricular dysfunction (left ventricular ejection fraction <40%), and urgent timing.
  
  
  CONCLUSIONS
  Redo MVR can be performed with an acceptable risk of mortality. Although preservation of the subvalvular apparatus may increase operative complexity, we recommend subvalvular preservation in order to decrease the risk of early mortality.
authors.affiliation: Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, Ontario, Canada. michael.borger@utoronto.ca
authors.forename: Michael A
authors.initials: MA
authors.lastname: Borger
authors.forename: Terrence M
authors.initials: TM
authors.lastname: Yau
authors.forename: Vivek
authors.initials: V
authors.lastname: Rao
authors.forename: Hugh E
authors.initials: HE
authors.lastname: Scully
authors.forename: Tirone E
authors.initials: TE
authors.lastname: David
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000601:surgery; D002423:Cause of Death; D015331:Cohort Studies; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass; D005260:Female; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality / Q000601:surgery*; D011446:Prospective Studies; D012086:Reoperation / Q000379:methods; D012307:Risk Factors; D015996:Survival Rate; D014261:Tricuspid Valve / Q000601:surgery