title: Rifampicin concentrations in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum following a single 600 mg oral dose in patients undergoing fibre-optic bronchoscopy.
abstract: The concentrations of rifampicin in epithelial lining fluid (ELF), human alveolar macrophages (AM), bronchial mucosal biopsies and serum were measured after a single oral dose of 600 mg rifampicin from 15 patients undergoing fibre-optic bronchoscopy. The samples of ELF, AM, the bronchial mucosal biopsies and serum were obtained approximately 2-5 h after dosing. The mean concentrations (mean +/- standard error) were 5.25 mg/L (+/-0.67) in ELF, 7.93 mg/kg (+/-1.61) in bronchial biopsies, 15.48 mg/L (+/-1.41) in serum and 251.8 mg/L (+/-65.92) in alveolar macrophages. These site concentrations exceeded the MIC90 for common respiratory pathogens including Mycobacterium tuberculosis and support the observed clinical efficacy of rifampicin in the treatment of a wide range of respiratory tract infections.
authors.affiliation: Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK.
authors.forename: Hisham M
authors.initials: HM
authors.lastname: Ziglam
authors.forename: David R
authors.initials: DR
authors.lastname: Baldwin
authors.forename: Ian
authors.initials: I
authors.lastname: Daniels
authors.forename: Jenny M
authors.initials: JM
authors.lastname: Andrew
authors.forename: Roger G
authors.initials: RG
authors.lastname: Finch
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001999:Bronchoscopy / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010361:Patients / Q000706:statistics & numerical data; D020545:Respiratory Mucosa / Q000187:drug effects / Q000378:metabolism*; D012293:Rifampin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D012293:Rifampin