Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population.
Psoriasis is a chronic inflammatory skin disorder showing multifactorial inheritance. Linkage studies have mapped disease susceptibility loci to several genomic regions, including the chromosome 16 interval that contains the CARD15/NOD2 gene. CARD15 has been involved in Crohn's Disease (CD) susceptibility and it has been hypothesised that it may also contribute to the pathogenesis of psoriasis. To test this hypothesis we studied the distribution of 3 CARD15 SNPs in an Italian case-control data set. We failed to observe any significant difference between patients and controls, thereby excluding the presence of a strong genetic association between CARD15 gene polymorphisms and psoriasis, in the Italian population.
Borgiani
Paola
P
Centro di Eccellenza per lo Studio del Rischio Genomico in Patologie Complesse Multifattoriali, Facoltà di Medicina, Università di Roma Tor Vergata, Via Montpellier 1, Italy.
Vallo
Laura
L
D'Apice
Maria Rosaria
MR
Giardina
Emiliano
E
Pucci
Sabina
S
Capon
Francesca
F
Nisticò
Steven
S
Chimenti
Sergio
S
Pallone
Francesco
F
Novelli
Giuseppe
G
D000483:Alleles; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007558:Italy / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D053473:Nod2 Signaling Adaptor Protein; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011336:Probability; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D012016:Reference Values; D012720:Severity of Illness Index
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein