Family-based association tests for quantitative traits using pooled DNA.
Interest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.
Bader
Joel S
JS
CuraGen Corporation, 555 Long Wharf Drive, New Haven, Connecticut, CT 06511 USA. jsbader@curagen.com
Sham
Pak
P
D002874:Chromosome Mapping / Q000379:methods*; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification*; D005260:Female; D005787:Gene Frequency; D015894:Genome, Human; D006801:Humans; D008297:Male; D040641:Quantitative Trait Loci / Q000235:genetics*
D004247:DNA