Roles of EBF and Pax-5 in B lineage commitment and development.
B lymphocyte development is regulated by the nuclear proteins Early B cell factor (EBF) and Pax-5. EBF and Pax-5 work separately and in concert to activate genes required for B cell differentiation. Recent studies have defined mechanisms by which these two factors control transcription, including chromatin remodeling activities and recruitment of partner proteins. This review addresses the structures, functions, and roles of these proteins in early B cell commitment and development, as well as in later stages of B cell differentiation.
Maier
Holly
H
Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street K516B, Denver, CO 80206, USA.
Hagman
James
J
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D019070:Cell Lineage / Q000235:genetics / Q000276:immunology; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D018507:Gene Expression Regulation, Developmental / Q000276:immunology; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D038041:Lymphopoiesis / Q000235:genetics* / Q000276:immunology; D051757:PAX5 Transcription Factor; D017433:Protein Structure, Secondary; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology*
D004268:DNA-Binding Proteins; C081976:EBF1 protein, human; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D015534:Trans-Activators; D014157:Transcription Factors