[Role of gemcitabine in the treatment of other malignant tumors].
The therapeutic interest of gemcitabine both as a single drug and in combination is now well known and applied in various malignant diseases. However, it would be worth being further explored in two tumor models for which its efficacy has been suspected and which have been somehow "abandoned" by modern oncology after the demonstration of their high sensitivity to platinum derivatives, namely epidermoid tumours of the upper aero-digestive tract and uterine cervix. Combination studies should be encouraged in this setting.
Clippe
Christine
C
Unité fonctionnelle d'oncologie médicale, Centre hospitalier Lyon-Sud, Hospices civils de Lyon, 69495 Pierre-Bénite.
Ligneau
Blandine
B
Trillet-Lenoir
Véronique
V
D000230:Adenocarcinoma / Q000188:drug therapy; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D016879:Salvage Therapy; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine