title: Synthetic studies of cis-4-Amino-L-proline derivatives as novel lipid lowering agents.
abstract: cis-4-Amino-L-proline derivatives 1 and 2 derived from quinazolinone and pyrazolo pyrimidone respectively were designed as novel lipid lowering agents. A preliminary in vivo screening indicates that 1b and 2a have moderate triglyceride lowering activity.
authors.affiliation: Discovery Chemistry, Dr. Reddy's Discovery Research, Bollaram Road, Miyapur, Hyderabad 500050, India. saibalkumardas@drreddys.com
authors.forename: Saibal Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: V L
authors.initials: VL
authors.lastname: Narasimha Rao Krovvidi
authors.forename: H
authors.initials: H
authors.lastname: Jagadheshan
authors.forename: Javed
authors.initials: J
authors.lastname: Iqbal
mesh_terms: D000818:Animals; D015228:Hypertriglyceridemia / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011744:Pyrimidinones / Q000737:chemistry; D011799:Quinazolines / Q000737:chemistry; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D011744:Pyrimidinones; D011799:Quinazolines; D014280:Triglycerides; D011392:Proline