title: [Cardiotropic activity of total bufadienolides from the poison of Central Asian toad Bufo viridis].
abstract: The sum of bufadienolides (bacagin) isolated from the poison of Bufo viridis toad occurring in Central Asia produces a selective strophanthin-K-like action upon the heart function, increasing myocardial contractility, retarding cardiac rhythm, and positively influencing the parameters of myocardial metabolism. The mechanism of realization of the positive ionotropic effect of bacagin is probably related to the ability of increasing the basal level of cytosol calcium at the expense of inhibiting the activity of Na+/K(+)-ATPase and, to some extent, Ca(2+)-ATPase in endoplasmic reticulum.
authors.affiliation: Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, ul. Kh. Abdulaeva 77, Tashkent, 700170 Uzbekistan.
authors.forename: I V
authors.initials: IV
authors.lastname: Usanova
authors.forename: Z A
authors.initials: ZA
authors.lastname: Khushbaktova
authors.forename: V N
authors.initials: VN
authors.lastname: Syrov
authors.forename: D E
authors.initials: DE
authors.lastname: Azizov
authors.forename: Sh Ia
authors.initials: ShIa
authors.lastname: Mirzaakhmedov
authors.forename: A B
authors.initials: AB
authors.lastname: Soliev
authors.forename: M S
authors.initials: MS
authors.lastname: Tashmukhamedov
authors.forename: Sh I
authors.initials: ShI
authors.lastname: Salikhov
mesh_terms: D000818:Animals; D002018:Bufanolides / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002025:Bufonidae; D002118:Calcium / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects*; D009205:Myocarditis / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013328:Strophanthins / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism
chemical_list: D002018:Bufanolides; D002316:Cardiotonic Agents; D013328:Strophanthins; C029082:strophanthin K; D002118:Calcium