Peripheral nerve granuloma in a patient with tuberculosis.
The cause of peripheral neuropathy associated with tuberculosis is controversial. Possibilities include an immune mediated neuropathy, direct invasion of nerves, vasculitic neuropathy, compressive neuropathy, a meningitic reaction, and the toxic effects of antituberculous chemotherapy. This report describes the unusual finding of granulomas in the peripheral nerve of a patient with tuberculosis. The pathological findings were of a delayed hypersensitivity reaction, but with no more specific indications of the mechanism of the neuropathy.
Orrell
R W
RW
University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, UK. r.orrell@rfc.ucl.ac.uk
King
R H M
RH
Bowler
J V
JV
Ginsberg
L
L
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D014375:Tuberculoma / Q000175:diagnosis* / Q000473:pathology; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis / Q000473:pathology