Effects of digestive status on the reptilian gut.
Reptiles, including the Burmese python, Python molurus bivittatus, that feed at infrequent intervals show a prominent increase in gastrointestinal mass, metabolism and brush border transport rates after feeding. Current knowledge and theories around these phenomena, as well as studies on the innervation of the reptilian gut, are summarised in this review. Little is known about the putative changes in the nervous and humoral control systems of the gut, and it is not known whether feeding affects innervation and motility of the stomach and intestine. Using immunohistochemistry, we have investigated possible up/down regulation of several neurotransmitters in specimens that had been fasted for a minimum of 3 weeks and specimens that had ingested a large meal 2 days before the experiments were conducted. There were no major changes in the innervation by nerves containing calcitonin gene-related peptide (CGRP), galanin, nitric oxide synthase (NOS), pituitary adenylate cyclase-activating polypeptide (PACAP), somatostatin (SOM), substance P/neurokinin A (SP/NKA), or vasoactive intestinal polypeptide (VIP)-like immunoreactivity. Nor did we find any differences in the effect of substance P (stomach and intestine), galanin (intestine), or bradykinin (intestine) on motility in strip preparations from the gut wall. A significant increase in dry weight of the intestine was obtained 48 h after feeding. We conclude that although there are considerable changes in gut thickness and absorptive properties after feeding, the smooth muscle and its control appear little affected.
Holmberg
Anna
A
University of Göteborg, Department of Zoology/Zoophysiology, Box 463, SE-405 30, Göteborg, Sweden. anna.holmberg@zool.gu.se
Kaim
Joanna
J
Persson
Anette
A
Jensen
Jörgen
J
Wang
Tobias
T
Holmgren
Susanne
S
D000818:Animals; D017821:Boidae / Q000502:physiology*; D004063:Digestion / Q000502:physiology*; D004435:Eating / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D007422:Intestines / Q000502:physiology*