title: Arterial distensibility: acute changes following dynamic exercise in normal subjects.
abstract: The time course of acute changes in large artery distensibility immediately and for 60 min following maximum treadmill exercise in normal subjects was characterized by simultaneously measuring upper and lower limb pulse wave velocity (PWV). A new oscillometric technique was used, which has proven to be sensitive to changes in distensibility induced by acute changes in vascular tone independently of blood pressure. The observed changes in PWV are attributable to changes in vascular tone corresponding to recovery from a systemic net constrictor response and a local net dilator response to exercise with persisting postexercise vasodilatation. They are inadequately explained by associated changes in blood pressure and cannot be attributed to changes in heart rate or viscosity. Modeled as a system of n coupled linear differential equations, the minimum (and adequate) order required to reproduce these patterns was n = 1 for the upper and n = 2 for the exercising lower limb. The economy of the solution suggests entrainment among the multiple interactive mechanisms governing vasomotor control.
authors.affiliation: Department of Cardiology, Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom.
authors.forename: Katerina K
authors.initials: KK
authors.lastname: Naka
authors.forename: Ann C
authors.initials: AC
authors.lastname: Tweddel
authors.forename: Dimitris
authors.initials: D
authors.lastname: Parthimos
authors.forename: Andrew
authors.initials: A
authors.lastname: Henderson
authors.forename: Jonathan
authors.initials: J
authors.lastname: Goodfellow
authors.forename: Michael P
authors.initials: MP
authors.lastname: Frenneaux
mesh_terms: D000293:Adolescent; D000328:Adult; D001132:Arm / Q000098:blood supply; D001158:Arteries / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D005082:Physical Exertion / Q000502:physiology*; D011673:Pulsatile Flow / Q000502:physiology; D012016:Reference Values; D013997:Time Factors; D014664:Vasodilation / Q000502:physiology*