title: Association of chromosome 10 losses and negative prognosis in oligoastrocytomas.
abstract: Oligoastrocytomas are mixed gliomas harboring different genetic alterations and with heterogeneous clinical evolution. We have looked for correlations between genetic losses and clinical evolution in 34 oligoastrocytomas. Loss of heterozygosity (LOH) with different microsatellite markers was studied on chromosomes 1p, 10q, 17p, and 19q. LOH on 1p was found in 44% of the tumors, on 10q in 24%, on 17p in 18%, and on 19q in 38%. LOH on 1p and 19q was combined in 29% of the patients. LOH on 1p was associated with significantly longer overall survival (p = 0.0092) and LOH on 10q with shorter overall survival (p = 0.0206). The observation that LOH on 10q predicts a short survival in oligoastrocytomas is novel and provides further evidence that genetic analysis may help to predict the clinical evolution of different gliomas, giving a more rationale basis to therapeutic options.
authors.affiliation: Department of Experimental Neurology and Diagnostics, Istituto Nazionale Neurologico Besta, Via Celoria 11, 20133 Milan, Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Bissola
authors.forename: Marica
authors.initials: M
authors.lastname: Eoli
authors.forename: Bianca
authors.initials: B
authors.lastname: Pollo
authors.forename: Bianca Maria
authors.initials: BM
authors.lastname: Merciai
authors.forename: Antonio
authors.initials: A
authors.lastname: Silvani
authors.forename: Ettore
authors.initials: E
authors.lastname: Salsano
authors.forename: Carmelo
authors.initials: C
authors.lastname: Maccagnano
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bruzzone
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Fuhrman Conti
authors.forename: Carlo Lazzaro
authors.initials: CL
authors.lastname: Solero
authors.forename: Sergio
authors.initials: S
authors.lastname: Giombini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Broggi
authors.forename: Amerigo
authors.initials: A
authors.lastname: Boiardi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Finocchiaro
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D016009:Chi-Square Distribution; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate