title: The molecular characteristics of circumsporozoite protein gene subtypes from Plasmodium vivax isolates in Republic of Korea.
abstract: The circumsporozoite protein (CSP) of Plasmodium vivax has two sequence types, VK210 and VK247, each of which has a characteristic tandem amino acid repetition. Previous studies report that a resurgent Korean strain has unique amino acid sequences in tandem repeats and post-repeat areas compared to other strains of P. vivax. We have found another molecular subtype of the CSP gene from resurgent Korea isolates. New strains show a total of eighteen amino acid repeats and different amino acid repeat patterns compared with previous resurgent Korean isolates. In the post-repeat region, AGGNAANKKAEDAGGNA and three repeats of the sequence GGNA was found in all six isolates. These results of sequence comparison revealed that there are two types of isolates based on CSP in South Korea.
authors.affiliation: Department of Obstetrics and Gynecology, Korea University Ansan Hospital, 516, Gojan Dong, Ansan City, 425-707, Republic of Korea.
authors.forename: Tak
authors.initials: T
authors.lastname: Kim
authors.forename: Yoo Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Ki-Joon
authors.initials: KJ
authors.lastname: Song
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Song
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Cha
authors.forename: Yong Ku
authors.initials: YK
authors.lastname: Kim
authors.forename: Young Kyu
authors.initials: YK
authors.lastname: Shin
authors.forename: In Bum
authors.initials: IB
authors.lastname: Suh
authors.forename: Chae Seung
authors.initials: CS
authors.lastname: Lim
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D007723:Korea; D008969:Molecular Sequence Data; D010802:Phylogeny; D010966:Plasmodium vivax / Q000235:genetics* / Q000302:isolation & purification; D015800:Protozoan Proteins / Q000235:genetics* / Q000302:isolation & purification; D017385:Sequence Homology
chemical_list: D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan