[Stress-protector effect of diprim].
Diprim, a polyphenol preparation from crests of Far-Eastern grape species, influences the carbohydrate and lipid metabolism in liver of rats subjected to stress. The drug possesses antistress properties determined by the biologically active natural polyphenol derivatives. Playing the role of a buffer redox system under the stressed conditions, the polyphenol structures provide for the possibility of retaining the carbohydrate and lipid metabolism in rat liver and creating a reserve of the oxidized form of nicotinamide NAD+ coenzyme, which favors removal of the tissue hypoxia. The antioxidant properties of polyphenols from diprim preserve the phospholipid spectrum of the plasmic membranes of hepatocytes.
Sprygin
V G
VG
Department of Biochemical Technologies, Il'ichev Pacific Oceanological Institute, Far East Division, Russian Academy of Sciences, ul. Baltiiskaya 43, Vladivostok, 690041 Russia.
Kushnerova
N F
NF
Gordeĭchuk
T N
TN
Fomenko
S E
SE
D000311:Adrenal Glands / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D010743:Phospholipids / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems / Q000737:chemistry; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology; D013276:Stomach Ulcer / Q000188:drug therapy; D013312:Stress, Physiological / Q000503:physiopathology*; D027843:Vitis / Q000737:chemistry*
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010743:Phospholipids; D010936:Plant Extracts; D011108:Polymers; D059808:Polyphenols