Serotonin modulates neuromuscular transmission in frogs.
The effect of 5-hydroxytryptamine (serotonin) on neuromuscular transmission in frog skeletal muscle was studied using voltage clamp technique. Serotonin produced no effect on end-plate currents during low frequency electrical stimulation of the motor nerve, but increased the amplitude depression of multiquantal currents during high-frequency stimulation similar to motor commands fired by motoneurons. It was shown that the inhibitory effect of serotonin on neuromuscular transmission is determined by slow potential-dependent block of open ionic channels in the postsynaptic membrane accumulating during rhythmic activation of the synapse.
Khabibullina
N K
NK
Kazan State Medical University. ask@ksu.ru
Shakirzyanova
A V
AV
Skorinkin
A I
AI
Afzalov
R A
RA
Giniatullin
R A
RA
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000494:pharmacology; D000818:Animals; D004594:Electrophysiology; D007477:Ions; D008564:Membrane Potentials; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009388:Neostigmine / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D011898:Ranidae; D012584:Sciatic Nerve / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D007477:Ions; D012701:Serotonin; D009388:Neostigmine; D000110:Acetylcholinesterase; D000109:Acetylcholine