Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding.
Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.
Krantz
Bryan A
BA
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.
Mayne
Leland
L
Rumbley
Jon
J
Englander
S Walter
SW
Sosnick
Tobin R
TR
D000818:Animals; D001426:Bacterial Proteins; D003574:Cytochrome c Group / Q000737:chemistry*; D019791:Guanidine / Q000494:pharmacology; D006321:Heart; D006736:Horses; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D011487:Protein Conformation; D011489:Protein Denaturation; D017510:Protein Folding; D012259:Ribonuclease, Pancreatic / Q000737:chemistry*; D012260:Ribonucleases / Q000737:chemistry*; D013816:Thermodynamics; D013997:Time Factors; D025801:Ubiquitin / Q000737:chemistry*
D001426:Bacterial Proteins; D003574:Cytochrome c Group; C029152:G-substrate; D009419:Nerve Tissue Proteins; D025801:Ubiquitin; D012260:Ribonucleases; C019760:Bacillus amyloliquefaciens ribonuclease; D012259:Ribonuclease, Pancreatic; D019791:Guanidine