Mechanisms of cellular iron acquisition: another iron in the fire.
Iron transport occurs by the well-known transferrin (Tf)-transferrin receptor (Tf receptor) system and by a second as yet uncharacterized system. Two reports in the current issue of Molecular Cell suggest an unexpected candidate for the Tf-independent system.
Kaplan
Jerry
J
Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA. jerry.kaplan@path.utah.edu
D000209:Acute-Phase Proteins / Q000378:metabolism; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D001692:Biological Transport; D027682:Cation Transport Proteins / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D064451:Hepcidins; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D033862:Iron-Binding Proteins / Q000378:metabolism; D007781:Lactoferrin / Q000378:metabolism; D000071068:Lipocalin-2; D054834:Lipocalins; D008954:Models, Biological; D015513:Oncogene Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D011990:Receptors, Transferrin / Q000378:metabolism; D017262:Siderophores / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2
D000209:Acute-Phase Proteins; D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; D064451:Hepcidins; D007501:Iron; D033862:Iron-Binding Proteins; D007781:Lactoferrin; D000071068:Lipocalin-2; D054834:Lipocalins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D011990:Receptors, Transferrin; D017262:Siderophores; D014168:Transferrin; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2; C489506:LCN2 protein, human