title: Adduct of 2-[18F]FDG and 2-nitroimidazole as a putative radiotracer for the detection of hypoxia with PET: synthesis, in vitro- and in vivo-characterization.
abstract: A new sugar-coupled 2-nitroimidazole derivative ([18F](see structure in text)) has been prepared in good radiochemical yields starting from peracetylated 2-[18F]FDG obtained from an automated 2-[18F]FDG production module. The corresponding glucose derivative (see structure in text) has proved to be able to inhibit 2-[18F]FDG uptake into tumor cells in a concentration dependent way. However, [18F](see structure in text) failed to show a retention in hypoxic tumor tissue thus excluding itself from further investigations.
authors.affiliation: Institut für Interdisziplinäre Isotopenforschung e.V. an der Universität Leipzig, Germany. patm@medizin.uni-leipzig.de
authors.forename: Marianne
authors.initials: M
authors.lastname: Patt
authors.forename: Dietlind
authors.initials: D
authors.lastname: Sorger
authors.forename: Matthias
authors.initials: M
authors.lastname: Scheunemann
authors.forename: Gerhard
authors.initials: G
authors.lastname: Stöcklin
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging; D005260:Female; D005462:Fluorine Radioisotopes / Q000737:chemistry; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging; D009593:Nitroimidazoles / Q000138:chemical synthesis / Q000737:chemistry; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014055:Tomography, Emission-Computed; D014407:Tumor Cells, Cultured
chemical_list: D005462:Fluorine Radioisotopes; D009593:Nitroimidazoles; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18