High 1,5-anti stereoinduction in boron-mediated aldol reactions of methyl ketones.
[reaction: see text] We report herein a very efficient and synthetically useful 1,4-anti-1,5-anti boron-mediated aldol reaction of a chiral alpha-methyl-beta-alkoxy methyl ketone with achiral aldehydes.
Dias
Luiz C
LC
Instituto de Química, Universidade Estadual de Campinas, UNICAMP, C.P. 6154 13083-970, Campinas, SP, Brazil. ldias@iqm.unicamp.br
Baú
Rosana Z
RZ
De Sousa
Márcio A
MA
Zukerman-Schpector
J
J