title: Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease.
abstract: OBJECTIVE
  Some previous reports suggested a potential role of insulin in memory and in the pathophysiology of Alzheimer's disease (AD). We assessed the cerebrospinal fluid (CSF) levels of insulin in patients with AD and in age and sex-matched controls trying to elucidate whether this value could be related with the risk or severity of AD.
  
  
  METHODS
  We measured the CSF insulin levels in 27 patients with AD and 16 matched controls using a RadioImmunoanalysis method.
  
  
  RESULTS
  CSF insulin levels did not differ significantly between AD-patient and control groups. These values were not correlated with age, age at onset, duration of the disease, and scores of the MiniMental State Examination in the AD group.
  
  
  CONCLUSIONS
  These results suggest that CSF insulin concentrations are not related with the risk or severity of AD.
authors.affiliation: Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Molina
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: C
authors.initials: C
authors.lastname: Vargas
authors.forename: P
authors.initials: P
authors.lastname: Gómez
authors.forename: F
authors.initials: F
authors.lastname: de Bustos
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Escalonilla
authors.forename: M
authors.initials: M
authors.lastname: Zurdo
authors.forename: A
authors.initials: A
authors.lastname: Tallón
authors.forename: A
authors.initials: A
authors.lastname: Martínez-Salio
authors.forename: J
authors.initials: J
authors.lastname: Porta-Etessam
authors.forename: C
authors.initials: C
authors.lastname: Villanueva
authors.forename: J
authors.initials: J
authors.lastname: Arenas
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000503:physiopathology* / Q000523:psychology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007328:Insulin / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D013129:Spinal Puncture
chemical_list: D015415:Biomarkers; D007328:Insulin