title: Long-term results of a prospective randomized study comparing two immunosuppressive regimens, one with and one without CsA, in low-risk renal transplant recipients.
abstract: Due to the nephrotoxicity of cyclosporin A (CsA), its benefit on long-term graft survival remains controversial, especially in low-risk patients. Here we report the 12-year results of a calcineurin-inhibitor-free regimen. One hundred and seventeen low-risk kidney recipients were prospectively randomized to maintenance therapy with either a combination of azathioprine and prednisone (group NoCsA, n=58), or with cyclosporine, azathioprine, and prednisone (group CsA, n=59). Both groups received induction therapy with anti-lymphocyte globulins (ALG). Twelve-year patient survival was 75% and 82.5% in the CsA and NoCsA groups, respectively [ P= not significant (NS)]. Twelve-year graft survival was 59% and 56% ( P=NS) in the CsA and NoCsA groups, respectively (NS). Transplant rejection rates were similar in both groups. Mean serum creatinine levels after 10 years were 161 and 136 micromol/l in the CsA and NoCsA groups, respectively. Rejection-free patients of the CsA group had poorer renal function (168 micromol/l) than those of the NoCsA group (121 micromol/l; P=0.0060). We concluded that a 12-year graft survival of 56% and a graft half-life of 15 years can be achieved without the primary use of a calcineurin inhibitor in low-risk patients receiving ALG. Patients treated with CsA had poorer graft function at 12 years.
authors.affiliation: Service de Nephrologie, Hôpital Henri Mondor, Avenue du Marechal de Lattre Tassigny, 94000 Créteil, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Grimbert
authors.forename: Christophe
authors.initials: C
authors.lastname: Baron
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Fruchaud
authors.forename: François
authors.initials: F
authors.lastname: Hemery
authors.forename: Dominique
authors.initials: D
authors.lastname: Desvaux
authors.forename: Claude
authors.initials: C
authors.lastname: Buisson
authors.forename: Dominique
authors.initials: D
authors.lastname: Chopin
authors.forename: Djamel
authors.initials: D
authors.lastname: Dahmane
authors.forename: Philippe
authors.initials: P
authors.lastname: Remy
authors.forename: Myriam
authors.initials: M
authors.lastname: Pastural
authors.forename: Claude
authors.initials: C
authors.lastname: Abbou
authors.forename: Bertrand
authors.initials: B
authors.lastname: Weil
authors.forename: Philippe
authors.initials: P
authors.lastname: Lang
mesh_terms: D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015994:Incidence; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D019233:Retreatment; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000961:Antilymphocyte Serum; D004338:Drug Combinations; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine; D001379:Azathioprine; D011241:Prednisone