Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.
Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.
Borstnik
Kristina
K
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.
Paik
Ik-hyeon
IH
Shapiro
Theresa A
TA
Posner
Gary H
GH
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D015195:Drug Design; D010545:Peroxides; D010961:Plasmodium / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010545:Peroxides; D012717:Sesquiterpenes; C467230:yingzhaosu A; C031327:artemisinin