title: Evidence for constitutive expression of bovine adrenal a3beta4* nicotinic acetylcholine receptors.
abstract: Many pathological conditions involve alterations in expression of nicotinic acetylcholine receptors (nAChRs). The following studies were designed to investigate cellular mechanisms involved with expression and turnover of alpha3beta4* nAChRs. These studies support constitutive turnover of adrenal alpha3beta4* nAChRs and the use of cultured adrenal chromaffin cells to study nAChR regulation.
authors.affiliation: Division of Pharmacology, The Ohio State University, College of Pharmacy, Columbus, Ohio 43210, USA.
authors.forename: R Benjamin
authors.initials: RB
authors.lastname: Free
authors.forename: Susan B
authors.initials: SB
authors.lastname: McKay
authors.forename: R Thomas
authors.initials: RT
authors.lastname: Boyd
authors.forename: Dennis B
authors.initials: DB
authors.lastname: McKay
mesh_terms: D000818:Animals; D002417:Cattle; D019439:Chromaffin Cells / Q000378:metabolism*; D015536:Down-Regulation; D005786:Gene Expression Regulation; D011691:Puromycin / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000096:biosynthesis* / Q000235:genetics*; D013997:Time Factors
chemical_list: D011978:Receptors, Nicotinic; C403530:nicotinic receptor alpha3beta4; D011691:Puromycin