Adrenal cortical adenoma with adrenalin-type neurosecretory granules clinically mimicking a pheochromocytoma.
Adrenal tumors often present with clinical features that are specific and unique to their endocrine metabolism. When these features are in conflict with the pathologic appearance of the tumor, there can be great consternation for both the pathologist and the surgeon. In the case reported herein, an adrenalectomy was performed for clinical features of pheochromocytoma that on gross and histologic examination had the pathologic features of an adrenal cortical adenoma. Electron microscopy subsequently revealed that the tumor cells contained adrenalin-type granules, explaining the clinical outcome. It is crucial for both the surgeon and the surgical pathologist to be aware of this possibility when the clinical and pathologic features of an adrenal tumor are not congruent.
Ivsic
Tomislav
T
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA.
Komorowski
Richard A
RA
Sudakoff
Gary S
GS
Wilson
Stuart D
SD
Datta
Milton W
MW
D000306:Adrenal Cortex Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D018246:Adrenocortical Adenoma / Q000473:pathology* / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004837:Epinephrine / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000473:pathology* / Q000648:ultrastructure; D022142:Secretory Vesicles / Q000473:pathology* / Q000648:ultrastructure
D004837:Epinephrine