title: Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.
abstract: ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified. This study used QRT-PCR to quantitatively map the transcriptional expression profile of ACE 2 (and the two isoforms of ACE) in 72 human tissues. While confirming that ACE 2 expression is high in renal and cardiovascular tissues, the novel observation has been made that ACE 2 shows comparably high levels of expression in the gastrointestinal system, in particular in ileum, duodenum, jejunum, caecum and colon. Therefore, in probing the functional significance of this novel peptidase, some consideration should be given to a role in gastrointestinal physiology and pathophysiology.
authors.affiliation: Pharmagene Laboratories Ltd., 2 Orchard Rd., Royston, Hertfordshire SG8 5HD, UK. dan.harmer@pharmagene.com
authors.forename: Dan
authors.initials: D
authors.lastname: Harmer
authors.forename: Maureen
authors.initials: M
authors.lastname: Gilbert
authors.forename: Richard
authors.initials: R
authors.lastname: Borman
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Clark
mesh_terms: D000085962:Angiotensin-Converting Enzyme 2; D002268:Carboxypeptidases / Q000096:biosynthesis / Q000235:genetics*; D004064:Digestive System / Q000201:enzymology; D020869:Gene Expression Profiling; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis / Q000235:genetics; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014018:Tissue Distribution; D014158:Transcription, Genetic
chemical_list: D020033:Protein Isoforms; D012333:RNA, Messenger; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2