[Renoprotective effect of monopril in patients with diabetes mellitus in the preclinical stage of diabetic nephropathy].
As many as 15 patients with insulin-dependent diabetes mellitus received monopril in a dose of 5 mg daily. Studied in the patients was the drug effect on the functional renal reserve and glomerular filtration rate. Determination of the functional renal reserve has been shown to be a criterion for an early diagnosis of the preclinical stage of diabetic nephropathy. Administration of monopril in exhausted functional renal reserve permits preventing development of proteinuria or allows a lapse of time for it to develop.
Lapchyns'ka
I I
II
Zhurylo
T Ie
TIe
Seliuk
M M
MM
Hromova
A Ie
AIe
D000328:Adult; D000419:Albuminuria / Q000188:drug therapy / Q000209:etiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D017328:Fosinopril / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D017328:Fosinopril