Simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma: a potential pitfall in positron emission tomography imaging.
Positron emission tomography (PET) with [18F]fluorodeoxyglucose [18F]FDG has evolved as a method of increasingly clinical importance in the management of patients with malignant lymphoma. However, inflammatory lesions also accumulate [18F]FDG and may cause difficulties with interpretation. This report deals with 2 patients with simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma, a rare but known coincidence of diseases. In the first case, Hodgkin's disease could not be differentiated from eosinophilic granuloma. Positron emission tomography showed increased [18F]FDG uptake both in lymphoma manifestations and in the granuloma. In the second case with proven Hodgkin's disease, post-treatment examination showed a positive PET lesion in the mediastinal residual mass, which was interpreted as viable lymphoma. However, histologic examination revealed that it was an eosinophilic granuloma.
Naumann
Ralph
R
Department of Internal Medicine I, University Hospital Carl Gustav Carus at the Dresden University of Technology, Dresden, Germany. naumann@mk1.med.tu-dresden.de
Beuthien-Baumann
Bettina
B
Fischer
Rainer
R
Kittner
Thomas
T
Bredow
Jan
J
Kropp
Joachim
J
Ockert
Detlef
D
Ehninger
Gerhard
G
D000328:Adult; D004803:Eosinophilic Granuloma / Q000150:complications* / Q000175:diagnosis*; D004804:Eosinophils / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology; D008223:Lymphoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000379:methods*; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18