The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway.
The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex pathway.
Stecca
Barbara
B
Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
Ruiz i Altaba
Ariel
A
D000818:Animals; D053823:Hedgehog Proteins; D006801:Humans; D015513:Oncogene Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects*; D015534:Trans-Activators / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000627:therapeutic use*; D014157:Transcription Factors / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000627:therapeutic use*; D000071676:Zinc Finger Protein GLI1
D053823:Hedgehog Proteins; D015513:Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1