title: Optimization of the geometry and porosity of microelectrode arrays for sensor design.
abstract: This paper describes the systematic investigation of a range of microelectrode arrays with varying dimensions fabricated by standard photolithographic and reactive-ion etching techniques. As expected from theory, the electrochemical behavior of microelectrode arrays with a constant individual diameter varied strongly with center-to-center spacing, the larger the spacing the more sigmoidal the recorded voltammogram. Furthermore, the behavior of arrays with a constant relative center-to-center spacing is shown to vary with individual electrode diameter, the arrays with the smallest electrodes producing strongly peaked voltammograms. Peak current densities and signal-to-noise ratios were also obtained for a variety of array geometries, and the use of electrodeposited platinum black electrodes was investigated. To demonstrate one advantage of using a loosely packed microelectrode array in electroanalysis, a ferrocene-mediated enzyme-linked assay involving the biocatalytic reduction of H2O2 was investigated. Results showed an improved temporal response, with current-time transients reaching a steady-state response more quickly using arrays with increased center-center spacings.
authors.affiliation: Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, G12 8LT, UK.
authors.forename: Mairi E
authors.initials: ME
authors.lastname: Sandison
authors.forename: Natalie
authors.initials: N
authors.lastname: Anicet
authors.forename: Andrew
authors.initials: A
authors.lastname: Glidle
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Cooper
mesh_terms: D015374:Biosensing Techniques; D004563:Electrochemistry; D004797:Enzyme-Linked Immunosorbent Assay / Q000295:instrumentation; D007202:Indicators and Reagents; D008838:Microcomputers; D008839:Microelectrodes; D036103:Nanotechnology
chemical_list: D007202:Indicators and Reagents