title: Genetic interactions between the Wilms' tumor 1 gene and the p53 gene.
abstract: In recent years, a number of proteins have been identified that can modify the activities of the Wilms' Tumor 1 (WT1) proteins. One of these modifiers is the p53 protein. To investigate a genetic interaction between the p53 gene and the wt1 gene, we have crossed their respective knockout mice. The absence of p53 appears to have no gross effect on the phenotype of wt1-null mice. Both wt1-null and double-null embryos develop pericardial bleeding and die in utero. In adult p53-null mice, wt1-heterozygosity (wt1het) predisposes to an earlier onset of lymphomagenesis and the development of kidney abnormalities resembling oncocytoma in humans. wt1-heterozygosity alone predisposes to the development of glomerular sclerosis.
authors.affiliation: Central Hematologie Laboratory, University Medical Centre St. Radboud, 6500 HB, Nijmegen, the Netherlands.
authors.forename: Aswin L
authors.initials: AL
authors.lastname: Menke
authors.forename: Alan R
authors.initials: AR
authors.lastname: Clarke
authors.forename: Andrea
authors.initials: A
authors.lastname: Leitch
authors.forename: Annemieke
authors.initials: A
authors.lastname: Ijpenberg
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Williamson
authors.forename: Lee
authors.initials: L
authors.lastname: Spraggon
authors.forename: David J
authors.initials: DJ
authors.lastname: Harrison
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Hastie
mesh_terms: D018249:Adenoma, Oxyphilic / Q000235:genetics; D000818:Animals; D005260:Female; D016162:Genes, Wilms Tumor / Q000502:physiology*; D016158:Genes, p53 / Q000235:genetics*; D007678:Kidney Glomerulus / Q000473:pathology; D008223:Lymphoma / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012598:Sclerosis / Q000235:genetics; D013953:Thymus Neoplasms / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency / Q000235:genetics; D025721:WT1 Proteins / Q000172:deficiency / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; D025721:WT1 Proteins