Plasmodium falciparum serine repeat protein, a new target of monocyte-dependent antibody-mediated parasite killing.
Using monoclonal antibodies and human affinity-purified antibodies specific to the Plasmodium falciparum 126-kDa serine-rich protein, SERP, we found that these antibodies have no direct effect upon merozoite invasion at the concentrations tested but can cooperate with blood monocytes to strongly inhibit P. falciparum in vitro growth.
Soe
Soe
S
BioMedical Parasitology Unit, Pasteur Institute, 75015 Paris, France.
Singh
Subhash
S
Camus
Daniel
D
Horii
Toshihiro
T
Druilhe
Pierre
P
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000913:Antibodies, Protozoan / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D000953:Antigens, Protozoan / Q000276:immunology*; D006801:Humans; D051379:Mice; D009000:Monocytes / Q000276:immunology*; D010963:Plasmodium falciparum / Q000254:growth & development*
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; C057495:serine repeat antigen, Plasmodium