Pine resin and biopin ointment: effects of water-soluble fractions on cytokine production by peripheral blood neutrophils.
We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.
Simbirtsev
A S
AS
Institute of High-Purity Biological Preparations, St. Petersburg.
Konusova
V G
VG
McHedlidze
G Sh
GSh
Paramonov
B A
BA
Chebotarev
V Yu
VY
D001708:Biopterins / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009824:Ointments; D012116:Resins, Plant / Q000008:administration & dosage / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007378:Interleukins; D009824:Ointments; D012116:Resins, Plant; D014409:Tumor Necrosis Factor-alpha; D001708:Biopterins; C013893:rosin