title: Adult-onset idiopathic hypogonadotropic hypogonadism presented with erectile and ejaculatory disorder.
abstract: A 37-year-old man who had fathered a child five years previously presented with erectile and ejaculatory disorder. Endocrinological examinations revealed isolated luteinizing hormone-releasing hormone (LHRH) deficiency of hypothalamus, resulting in hypogonadotropic hypogonadism, and no causative abnormality was detected in imaging studies, including magnetic resonance imaging (MRI). Having a diagnosis of adult-onset hypogonadotropic hypogonadism, the patient received pulsatile subcutaneous administration of gonadotropin-releasing hormone (GnRH). Sperm analysis and serum level of testosterone improved to normal in a few months. His wife became pregnant using artificial insemination with her husband's semen 15 months after the beginning of the treatment.
authors.affiliation: Department of Urology, Graduate School of Medicine, Kyoto University and Clinical Research Institute, Kyoto National Hospital, Kyoto, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okuno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishiyama
authors.forename: Eijiro
authors.initials: E
authors.lastname: Nakamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawahara
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D005303:Fertility Agents, Male / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000172:deficiency; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000188:drug therapy*; D007027:Hypothalamic Diseases / Q000150:complications / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D007317:Insemination, Artificial, Homologous; D008297:Male; D011247:Pregnancy; D012735:Sexual Dysfunction, Physiological / Q000150:complications / Q000188:drug therapy*; D013076:Sperm Count; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
chemical_list: D005303:Fertility Agents, Male; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone