title: Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding.
abstract: Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Krantz
authors.forename: Leland
authors.initials: L
authors.lastname: Mayne
authors.forename: Jon
authors.initials: J
authors.lastname: Rumbley
authors.forename: S Walter
authors.initials: SW
authors.lastname: Englander
authors.forename: Tobin R
authors.initials: TR
authors.lastname: Sosnick
mesh_terms: D000818:Animals; D001426:Bacterial Proteins; D003574:Cytochrome c Group / Q000737:chemistry*; D019791:Guanidine / Q000494:pharmacology; D006321:Heart; D006736:Horses; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D011487:Protein Conformation; D011489:Protein Denaturation; D017510:Protein Folding; D012259:Ribonuclease, Pancreatic / Q000737:chemistry*; D012260:Ribonucleases / Q000737:chemistry*; D013816:Thermodynamics; D013997:Time Factors; D025801:Ubiquitin / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins; D003574:Cytochrome c Group; C029152:G-substrate; D009419:Nerve Tissue Proteins; D025801:Ubiquitin; D012260:Ribonucleases; C019760:Bacillus amyloliquefaciens ribonuclease; D012259:Ribonuclease, Pancreatic; D019791:Guanidine