Chromosomal localization of genes involved in biosynthesis, metabolism or transport of cholesterol in the rat.
Several genes involved in biosynthesis, transport or metabolism of cholesterol have been localized on rat chromosomes by using a radiation hybrid (RH) panel. The genes, coding for squalene epoxidase (Sqle), mevalonate kinase (Mvk), and farnesyl diphosphate farnesyl transferase 1 (Fdft1) which are involved in cholesterol biosynthesis, have been mapped on chromosome 7, 12, and 15, respectively. The genes coding for phospholipid transfer protein (Pltp), sterol carrier protein-2 (Scp2), ATP binding cassette reporter A7 (Abca7), scavenger receptor class B, type 1 (Cd36l1), steroidogenic acute regulatory protein (Star), and lecithin:cholesterol acyl transferase (Lcat), which are involved in the transfer and/or metabolism of cholesterol, have been mapped on chromosome 3, 5, 7, 12, 16, and 19, respectively. Each of the genes Scp2, Sqle and Fdft1 maps close to a QTL for serum total cholesterol in rat, suggesting that these three genes might represent candidate genes for the previously mapped QTLs.
Bonné
A C M
AC
Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands. Bonne@las.vet.uu.nl
den Bieman
M G
MG
Gillissen
G F
GF
van Lith
H A
HA
van Zutphen
L F M
LF
D000818:Animals; D001483:Base Sequence; D001692:Biological Transport; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D002874:Chromosome Mapping; D017931:DNA Primers; D040641:Quantitative Trait Loci; D051381:Rats
D017931:DNA Primers; D002784:Cholesterol