[Influence of xenon on reproductive function].
Wistar rats were used in the study. 15 male rats were exposed to Xe:O2(80:20) mixture for 2 hours twice a week during 10 weeks, and 60 female rats were affected similarly for 2 weeks. The three groups have been formed: 1st group consists of 15 exposed males joined by 30 control female rats, 2nd group includes 30 exposed female rats and 15 control male rats, 15 control male rats and 30 control female rats were in the 3rd group. Xe:O2(80:20) inhalation affect neither fertility and pregnancy indices, which reached 90%, nor body mass gain during pregnancy, nor pre- and postimplantation embryonal death, neonatal body mass and development. Xenon does not impair fine mechanisms of reproductive function, being most safe gas anesthetic with nice prospects for applying in obstetrical clinics.
Burov
N E
NE
Arzamastsev
E V
EV
Kornienko
L Iu
LIu
Kudimova
L A
LA
D018685:Anesthetics, Inhalation / Q000633:toxicity*; D000818:Animals; D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D008098:Litter Size / Q000187:drug effects; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D018812:Paternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D014978:Xenon / Q000633:toxicity*
D018685:Anesthetics, Inhalation; D014978:Xenon