title: Intrathecal morphine overdose during combined spinal-epidural block for Caesarean delivery.
abstract: We describe a 25 mg intrathecal morphine overdose during a combined spinal-epidural block for a Caesarean delivery. Naloxone infusion (5.24 mg over 24 h) was started prior to the patient becoming symptomatic and almost immediately after the overdose. Invasive therapeutics such as mechanical ventilation were avoided.
authors.affiliation: Service d'Anesthésie-Réanimation, Hôpital de l'Hôtel-Dieu, F-69002 Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Cannesson
authors.forename: N
authors.initials: N
authors.lastname: Nargues
authors.forename: B
authors.initials: B
authors.lastname: Bryssine
authors.forename: R
authors.initials: R
authors.lastname: Debon
authors.forename: E
authors.initials: E
authors.lastname: Boselli
authors.forename: D
authors.initials: D
authors.lastname: Chassard
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D000767:Anesthesia, Epidural / Q000379:methods; D000773:Anesthesia, Obstetrical / Q000379:methods*; D000775:Anesthesia, Spinal / Q000379:methods; D002585:Cesarean Section; D062787:Drug Overdose / Q000628:therapy; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008508:Medication Errors / Q000009:adverse effects; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D011247:Pregnancy
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine