Excitation propagation and force development in the left ventricle of the visible female data set.
Simulations of the electro-mechanical behavior of the heart improve the comprehension of the mechanisms of the cardiovascular system. In this study a left ventricular model including electrical excitation and force development is presented. The electrical model consists of a complex electrophysiological cell model and a monodomain excitation diffusion model. The force development bases on the intracellular calcium concentration and is calculated with a force model. It consists--like the electrophysiological model--of non-linear coupled differential equations. Simulations are obtained in a realistic and anisotropic model of the left ventricle of the Visible Female data set provided by the National Library of Medicine, USA. Effects to the mechanical behavior will be examined in future.
Seemann
G
G
Institut für Biomedizinische Technik, Universität Karlsruhe (TH), Germany. Gunnar.Seemann@ibt.uni-karlsruhe.de
Sachse
F B
FB
Dössel
O
O
D019412:Anatomy, Cross-Sectional; D015220:Calcium Channels / Q000502:physiology; D003198:Computer Simulation; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D008962:Models, Theoretical; D032342:Muscle Cells / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology*; D017711:Nonlinear Dynamics; D011690:Purkinje Fibers / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*
D015220:Calcium Channels