Blood plasma concentrations of oestradiol-17beta, testosterone and testosterone/oestradiol ratio in dogs with neoplastic and degenerative testicular diseases.
Oestradiol-17beta and testosterone blood plasma concentrations were measured in dogs with Leydig-cell tumours (n=20), Sertoli-cell tumours (n=6), seminomas (n=9), unilateral inguinal cryptorchidism (n=7), abdominal cryptorchidism (n=9, one bilateral), degenerate scrotal testicles (n=6, two bilateral), and animals with normal scrotal testicles (n=20). The testosterone/oestradiol ratio (testosterone concentration [ng/mL]x100/oestradiol concentration [pg/mL]) was calculated.A considerably higher oestradiol concentration was found in dogs with Sertoli-cell tumours (29.0, 14.4-48.3 pg/mL; median, minimum-maximum; P=0.0256, Mann-Whitney test) and lower oestradiol levels were found in animals with seminomas (12.0, 3.4-17.6 pg/mL; P=0.0025) compared to the healthy control group (18.0, 8.6-31.5 pg/mL). Testosterone concentration was decreased in dogs with Sertoli-cell tumours (0.08, 0.03-0.77 ng/mL) when compared to the control group (1.95, 0.05-3.70 ng/mL; P=0.0012). Testosterone/oestradiol ratios differed from the control (9.6, 0.58-35.8) only in dogs with Sertoli-cell tumours (0.32, 0.06-2.80; P=0.0005). Clinical signs of feminization were observed in five dogs with Sertoli-cell tumour and one dog with a Leydig-cell tumour, and were more often associated with decreased testosterone/oestradiol ratios than with an increased oestradiol-17beta concentration.
Mischke
R
R
Clinic for Small Animals, School of Veterinary Medicine, Hannover, Germany. reinhard.mischke@tiho-hannover.de
Meurer
D
D
Hoppen
H-O
HO
Ueberschär
S
S
Hewicker-Trautwein
M
M
D000818:Animals; D003456:Cryptorchidism / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood* / Q000473:pathology; D004285:Dogs; D004958:Estradiol / Q000097:blood*; D007984:Leydig Cell Tumor / Q000097:blood / Q000473:pathology / Q000662:veterinary; D008297:Male; D009919:Orchiectomy; D018239:Seminoma / Q000097:blood / Q000473:pathology / Q000662:veterinary; D012707:Sertoli Cell Tumor / Q000097:blood / Q000473:pathology / Q000662:veterinary; D018709:Statistics, Nonparametric; D013736:Testicular Neoplasms / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D004958:Estradiol