Optimisation of treatment by applying programmable rate-controlled drug delivery technology.
A number of programmable rate-controlled drug delivery technologies have been developed during the last two decades with the aim of regulating the rate of drug delivery, sustaining the duration of therapeutic action and/or targeting the delivery of drug to a specific tissue. As a result, several therapeutically beneficial outcomes can be achieved, such as: (i) controlled delivery of a therapeutic dose at a desirable rate of delivery; (ii) maintenance of drug concentrations within an optimal therapeutic range for prolonged duration of treatment; (iii) maximisation of efficacy-dose relationship; (iv) reduction of adverse effects; (v) minimisation of the need for frequent dose intake; and (vi) enhancement of patient compliance. The treatment of illness can thus be optimised. To gain a better understanding of how to optimise the treatment of illnesses by applying programmable rate-controlled drug delivery technologies, this article reviews the scientific concepts and technical principles behind the development of various programmable rate-controlled drug delivery systems that have been marketed or are under active development. Finally, the roles of these technologies in optimising therapeutic outcomes in nine therapeutic areas are discussed.
Chien
Yie W
YW
College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lin
Senshang
S
D000818:Animals; D016503:Drug Delivery Systems / Q000592:standards*; D004358:Drug Therapy; D005246:Feedback; D006801:Humans; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D016896:Treatment Outcome
D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations