title: Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions.
abstract: Multivalent protein-carbohydrate interactions regulate essential cellular events, including cell proliferation, adhesion and death. These multivalent interactions can create homogeneous complexes of lectins, such as the galectins, with their saccharide ligands. Lectin-saccharide complexes can concentrate specific glycoproteins or glycolipids within the lattice, while excluding other cell surface molecules. The formation of lectin-saccharide lattices on the cell surface can thus organize the plasma membrane into specialized domains that perform unique functions.
authors.affiliation: Departments of Molecular Pharmacology, Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: C Fred
authors.initials: CF
authors.lastname: Brewer
authors.forename: M Carrie
authors.initials: MC
authors.lastname: Miceli
authors.forename: Linda G
authors.initials: LG
authors.lastname: Baum
mesh_terms: D000818:Animals; D001665:Binding Sites; D002448:Cell Adhesion / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D037161:Galectins / Q000276:immunology; D006801:Humans; D037102:Lectins / Q000502:physiology*; D009844:Oligosaccharides / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D037161:Galectins; D037102:Lectins; D009844:Oligosaccharides