[Effects of dietary n-3 polyunsaturated fatty acid on lipid metabolism in rats under simulated weightlessness].
Objective. To study the effect of dietary n-3 polyunsaturated fatty acid (PUFA) on the lipid metabolism of tail-suspended rats. Method. 49 male Sprague-Dawley rats were divided into five groups: tail-suspension group I, fed with 10 wt % corn oil, tail-suspension groups II, III, IV were fed with three levels of fish oil (0.5, 1.5 or 3.0 wt %; low, middle and high level of fish oil, respectively). Group V fed with 10 wt % corn oil served as normal control. Result. Viscoelasticity of cell membrane in group III was significantly higher than that of group I (P<0.01); Vascular endothelial cells (VEC) was less in group II compared to group I; Serum total cholesterol (TC) and triglyceride (TG) , serum lipoprotein were lower in groups II, III, IV compared to group I, the higher fish oil content in diet, the lower serum lipid concentration in microgravity. Conclusion. Dietary n-3 PUFA do have distinguished effect on lipid metabolism and n-3 PUFA have certain effects on prevention of atherosclerotic disease and coronary heart disease in rats.
Wang
Lei
L
Bai
Shu-min
SM
Huang
Ji-ming
JM
Shi
Jie-ping
JP
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000502:physiology; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003314:Corn Oil / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004548:Elasticity / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology; D019417:Hindlimb Suspension; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D018474:Weightlessness Simulation
D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008055:Lipids; D014280:Triglycerides; D003314:Corn Oil; D002784:Cholesterol