title: Transport of xenobiotics across the blood-brain barrier.
abstract: Distinct transport proteins regulate the movement of waste products and xenobiotics across the blood-brain barrier (BBB). Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain.
authors.affiliation: Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland.
authors.forename: Bruno
authors.initials: B
authors.lastname: Hagenbuch
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Meier
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D015262:Xenobiotics / Q000493:pharmacokinetics*
chemical_list: D002352:Carrier Proteins; D015262:Xenobiotics