title: The EZH2 polycomb transcriptional repressor--a marker or mover of metastatic prostate cancer?
abstract: The recent finding of overexpression of the polycomb group transcriptional repressor EZH2 in prostate cancer raises the possibility that transcriptional regulation at the chromatin level may play a role in the development of the metastatic phenotype and suggests new avenues of exploration with respect to patient stratification and therapeutics.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. william_sellers@dfci.harvard.edu
authors.forename: William R
authors.initials: WR
authors.lastname: Sellers
authors.forename: Massimo
authors.initials: M
authors.lastname: Loda
mesh_terms: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000071221:Enhancer of Zeste Homolog 2 Protein; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D063151:Polycomb Repressive Complex 2; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D011506:Proteins / Q000032:analysis / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000502:physiology*; D014157:Transcription Factors; D014158:Transcription, Genetic; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D011506:Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; D014157:Transcription Factors; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2