Periodontal therapy using local delivery of antimicrobial agents.
Antimicrobial agents, systemic and/or local, are thought by some to be effective agents for treating periodontal infections. Here the authors determine the costs and benefits of local delivery agents for treating periodontal disease. Applying this cost-benefit analysis to patient care, however, will depend upon a clinician's expertise and a patient's value system.
Niederman
Richard
R
Center for Evidence-Based Dentistry, Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA. rniederman@forsyth.org
Abdelshehid
George
G
Goodson
J Max
JM
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000191:economics; D000890:Anti-Infective Agents / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002482:Cellulose / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003362:Cost-Benefit Analysis; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017277:Drug Approval; D016527:Drug Costs; D016503:Drug Delivery Systems / Q000191:economics; D005782:Gels / Q000008:administration & dosage; D005989:Glycerides / Q000008:administration & dosage; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008863:Microspheres; D008911:Minocycline / Q000008:administration & dosage; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000382:microbiology; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018570:Risk Assessment; D012715:Sesame Oil / Q000008:administration & dosage; D013752:Tetracycline / Q000008:administration & dosage; D016896:Treatment Outcome
C116585:Actisite; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; C094288:Elyzol Dentalgel; D005782:Gels; D005989:Glycerides; D008795:Metronidazole; D012715:Sesame Oil; D002482:Cellulose; D013752:Tetracycline; D008911:Minocycline; C010882:chlorhexidine gluconate; D004318:Doxycycline; D002710:Chlorhexidine