title: A tumor lysis-like syndrome during therapy of visceral leishmaniasis.
abstract: Reported herein for the first time in the literature is the case of a 41-yr-old woman who developed a tumor lysis-like syndrome, consisting of hyperkalemia, hyperphosphatemia, hyperuricemia, and acute renal insufficiency, soon after the initiation of chemotherapy for severe visceral leishmaniasis with liposomal amphotericin B. Allopurinol therapy, together with iv fluid administration and urine alkalization, resulted in full recovery of the metabolic abnormalities. Awareness of this condition can lead to prophylactic treatment as well as the early recognition and management of susceptible patients.
authors.affiliation: Department of Internal Medicine, University of Ioannina, Ioannina, Greece. egepi@cc.uoi.gr
authors.forename: Evagelos
authors.initials: E
authors.lastname: Liberopoulos
authors.forename: George
authors.initials: G
authors.lastname: Alexandridis
authors.forename: Moses
authors.initials: M
authors.lastname: Elisaf
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use; D000666:Amphotericin B / Q000009:adverse effects*; D000963:Antimetabolites / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D015275:Tumor Lysis Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D014556:Urine / Q000737:chemistry
chemical_list: D000963:Antimetabolites; D000981:Antiprotozoal Agents; D000493:Allopurinol; D000666:Amphotericin B