Chromogranin A-activated microglial cells induce neuronal apoptosis.
Chromogranin (CgA), a protein upregulated in many neuropathologies, can induce an activated phenotype in microglial cells that leads to neuronal apoptosis. The death-signaling pathways mobilized in neurons involve the death receptor Fas, p38 MAP kinase, and mitochondrial cytochrome c. We propose that CgA represents a potent endogenous inflammatory factor responsible for neuronal degeneration.
Ulrich
Gabrielle
G
CNRS UPR-2356 Neurotransmission et Secretion Neuroendocrine 5, 67084 Strasbourg Cedex, France.
Ciesielski-Treska
Jaroslava
J
Taupenot
Laurent
L
Bader
Marie-France
MF
D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000166:cytology; D002417:Cattle; D016923:Cell Death; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D003574:Cytochrome c Group / Q000378:metabolism; D006801:Humans; D017628:Microglia / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008954:Models, Biological; D009336:Necrosis; D009474:Neurons / Q000166:cytology* / Q000473:pathology; D010641:Phenotype; D015854:Up-Regulation; D048051:p38 Mitogen-Activated Protein Kinases
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D003574:Cytochrome c Group; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases