Synthesis of (25R)-26-hydroxycholesterol.
We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction.
Williams
John R
JR
Department of Chemistry, Temple University, 13th & Norris Streets, Beury Hall (016-00), Philadelphia, PA 19122-2585, USA. john.r.williams@temple.edu
Chai
Deping
D
Wright
Dominic
D
D006888:Hydroxycholesterols / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D006888:Hydroxycholesterols; C007042:cholest-5-ene-3 beta,26-diol