Early heart transplant in a child with advanced lymphoma.
A child with advanced stage large cell lymphoma in remission developed overwhelming, irreversible anthracycline cardiac toxicity incompatible with life early in her treatment course. The medical complexities and ethical issues concerning a decision to proceed with orthotopic heart transplantation are discussed.
Morgan
Elaine
E
Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA.
Pahl
Elfriede
E
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004317:Doxorubicin