Differential inductions of matrix metalloproteinase-2 and -9 in host tissues during the growth of ascitic sarcoma 180 cells in mice.
This study was designed to investigate the changes of matrix metalloproteinase (MMP)-2 and MMP-9 in host tissues in response to the growth of tumor cells. Zymogram showed that the responses of both MMPs in the host tissues were differential but concurrent. The liver, a prime target of metastases, had profound increases in MMP-2 and -9. The other usual targets had significant increases in MMP-9. MMP-2 was specifically increased in the spleen. These results indicate that the growth of tumor cells at the primary site could influence the MMP system of host tissues located at the distance.
Kuo
Wu-Hsien
WH
Division of Gastroenterology, Department of Internal Medicine, Armed-Force Taichung General Hospital, No 348, Section 2, Chung Shan Road, Taiping City, Taichung 411, Taiwan.
Yang
Shun-Fa
SF
Chu
Shu-Chen
SC
Lu
Shio-Ohin
SO
Chou
Fen-Pi
FP
Hsieh
Yih-Shou
YS
D000818:Animals; D008099:Liver / Q000378:metabolism; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D051379:Mice; D008813:Mice, Inbred ICR; D012510:Sarcoma 180 / Q000201:enzymology*; D013154:Spleen / Q000378:metabolism
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9