[Presence of urinary Sm28GST antigen in Madagascar patients with Schistosomiasis mansoni].
Using an ELISA method, we quantitated the level of glutathion S-transferase 28 kDa (Sm28GST), specific of Schistosoma mansoni, in the urine of 13 malagasy patients. The presence of Sm28GST antigen has been demonstrated for the first time, in 8 patients (69%). No significant correlation could be found between antigen level and the parasitological burden in the feces. The use of an immunocapture ELISA technic on a larger number of samples will be necessary to assess if this test could be quantitative and reliable enough for the diagnosis or the follow up of patients infected with Schistosoma mansoni.
Raobelison
A
A
Unité de Parasitologie, Institut Pasteur de Madagascar, BP 1274, 101 Antananarivo, Madagascar.
Neyrinck
J L
JL
Capron
A
A
Esterre
P
P
D000293:Adolescent; D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000652:urine*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods* / Q000592:standards; D005260:Female; D005982:Glutathione Transferase / Q000652:urine*; D006801:Humans; D008270:Madagascar; D008297:Male; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000145:classification / Q000276:immunology / Q000652:urine*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D000947:Antigens, Helminth; D005982:Glutathione Transferase