title: Markers that discriminate between European and African ancestry show limited variation within Africa.
abstract: Markers informative for ancestry are necessary for admixture mapping and improving case-control association analyses. In particular, African Americans are an admixed population for which genetic studies require accurately evaluating admixture. This will require markers that can be used in African Americans to determine if a given genomic region is of European or African ancestry. This report shows that, despite studies indicating high intra-African sequence variation, markers with large inter-ethnic differences have only small variations in allele distribution among divergent African populations and should be valuable for evaluating admixture in complex disease genetic studies.
authors.affiliation: Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616-8669, USA.
authors.forename: Heather E
authors.initials: HE
authors.lastname: Collins-Schramm
authors.forename: Rick A
authors.initials: RA
authors.lastname: Kittles
authors.forename: Darwin J
authors.initials: DJ
authors.lastname: Operario
authors.forename: James L
authors.initials: JL
authors.lastname: Weber
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Criswell
authors.forename: Richard S
authors.initials: RS
authors.lastname: Cooper
authors.forename: Michael F
authors.initials: MF
authors.lastname: Seldin
mesh_terms: D000349:Africa / Q000208:ethnology; D005060:Europe / Q000208:ethnology; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans
chemical_list: D005819:Genetic Markers