title: Hepatocellular carcinoma in a patient with acromegaly and high serum levels of insulin-like growth factor I: report of a case.
abstract: A 64-year-old woman with high serum levels of growth hormone, insulin-like growth factor-I (IGF-I), and alpha-fetoprotein resulting from partially treated acromegaly was found to have a tumor under the left diaphragm. The patient also had a history of type C viral hepatitis. Laparotomy revealed that the tumor was fixed to the diaphragm and connected to the liver and spleen. The tumor was excised with partial resection of the diaphragm, liver, and spleen, and a diagnosis of left-sided pedunculated hepatocellular carcinoma (HCC) was made. Further examination showed a higher level of IGF-I receptor mRNA in the tumor than in the normal liver parenchyma. We believe it is likely that the high serum levels of IGF-I may have played a role in the development of the pedunculated HCC in this patient.
authors.affiliation: Department of Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Genshu
authors.initials: G
authors.lastname: Tate
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Takemasa
authors.initials: T
authors.lastname: Midorikawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sanada
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kumada
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000150:complications*; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000209:etiology* / Q000601:surgery; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008113:Liver Neoplasms / Q000097:blood* / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone