Pathophysiology of Peyronie's disease.
Peyronie's disease is an inflammatory condition characterized by the formation of fibrous, noncompliant nodules in the tunica albuginea which can impede tunical expansion during penile erection, leading to deformity and bending. While the cause of this disease is thought to be due to microvascular trauma and abnormal wound healing, other hypotheses include genetic predisposition. In this review the pathophysiology of Peyronie's disease is discussed as well as current hypotheses regarding its origin.
Moreland
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RB
Department of Urology and Physiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Nehra
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D001808:Blood Vessels / Q000293:injuries; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015994:Incidence; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D010411:Penile Induration / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D010413:Penis / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D013314:Stress, Mechanical; D016212:Transforming Growth Factor beta / Q000378:metabolism; D053773:Transforming Growth Factor beta1; D014947:Wounds and Injuries / Q000150:complications
D005609:Free Radicals; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1