title: Chemical genetics: a small molecule approach to neurobiology.
abstract: Chemical genetics, or the specific modulation of cellular systems by small molecules, has complemented classical genetic analysis throughout the history of neurobiology. We outline several of its contributions to the understanding of ion channel biology, heat and cold signal transduction, sleep and diurnal rhythm regulation, effects of immunophilin ligands, and cell surface oligosaccharides with respect to neurobiology.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Koh
authors.forename: Craig M
authors.initials: CM
authors.lastname: Crews
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D020104:Immunophilins; D007473:Ion Channels / Q000502:physiology; D008565:Membrane Proteins / Q000187:drug effects / Q000378:metabolism; D008967:Molecular Biology / Q000379:methods* / Q000639:trends; D015336:Molecular Probe Techniques / Q000639:trends*; D009446:Neurobiology / Q000379:methods* / Q000639:trends; D013697:Thermosensing / Q000502:physiology
chemical_list: D007473:Ion Channels; D008565:Membrane Proteins; D020104:Immunophilins