Immunoglobulin transport across polarized epithelial cells.
IgA, IgG and IgM are transported across epithelial cells in a receptor-mediated process known as transcytosis. In addition to neutralizing pathogens in the lumen of the gastrointestinal, respiratory and urogenital tracts, these antibody-receptor complexes are now known to mediate intracellular neutralization of pathogens and might also be important in immune activation and tolerance. Recent studies on the intracellular transport pathways of antibody-receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways.
Rojas
Raul
R
Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Apodaca
Gerard
G
D000818:Animals; D018407:Bacterial Physiological Phenomena; D016764:Cell Polarity; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I; D006801:Humans; D018928:Immunity, Mucosal / Q000502:physiology; D007071:Immunoglobulin A, Secretory / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D021381:Protein Transport; D011961:Receptors, Fc / Q000276:immunology / Q000378:metabolism; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism
D015395:Histocompatibility Antigens Class I; D007071:Immunoglobulin A, Secretory; D007136:Immunoglobulins; D008024:Ligands; D011961:Receptors, Fc; D011994:Recombinant Proteins; C100688:Fc receptor, neonatal