Hyperhomocysteinaemia in Sri Lankan patients with coronary artery disease.
OBJECTIVE
To determine the association between hyperhomocysteinaemia and coronary artery disease (CAD) in a sample of Sri Lankans.


METHODS
A case control study.


METHODS
Asiri Hospital, Kirula Road, Colombo 5, Sri Lanka.


METHODS
105 patients with coronary artery disease and 112 controls.


METHODS
Fasting serum homocysteine levels were measured in 105 patients diagnosed as having CAD and in 112 unmatched controls. All patients admitted with clinical, electrocardiographical, biochemical or echocardiographical evidence of CAD were included in the study. Controls were selected from subjects admitted for health screening.


RESULTS
105 patients with CAD and 112 controls (unmatched for age and sex) were studied. A serum homocysteine level in excess of 18.2 mumol/l was considered high. Confounding effects of other conventional risk factors for CAD were controlled using multivariate logical regression analysis.


CONCLUSIONS
Hyperhomocysteinaemia is significantly associated with CAD. Multivariate logistic regression analysis indicated that the association between hyperhomocysteinaemia and CAD was confounded by other risk factors. However, statistical analysis revealed a significant independent association between hyperhomocysteinaemia and CAD (adjusted odds ratio = 2.881).
Mendis
Sriyantha
S
Asiri Hospital, Colombo. sriy@dynaweb.lk
Ranatunga
Pramod
P
Jayatilake
Mohan
M
Wanninayake
Sanjeewa
S
Wickremasinghe
Rajitha
R
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D013188:Sri Lanka / Q000453:epidemiology