title: Regulation of virus-induced interferon-A genes.
abstract: Different members of the interferon regulatory factor (IRF) family are early activated by viral infection of eukaryotic cells. The IRFs participate in the virus-induced transcriptional regulation of different genes, including the multigenic interferon-A (IFN-A) family, members of which are involved in the establishment of an antiviral state, cell growth inhibition or apoptosis. This study presents the recent progress in the field of virus-induced transactivation and repression of IFN-A gene promoters. Data presented on the modular organization of IFN-A gene promoters and their transactivation dependent on IRF-3 and IRF-7 provide a new insight on the cooperativity mechanisms among the different IRF family members. Data on the transcriptional repression of virus-induced interferon-A promoters by the homeodomain protein Pitx1 contribute to our understanding of the complex differential transcriptional activation, repression and antirepression of the IFN-A genes.
authors.affiliation: UPR 2228, CNRS, Laboratoire de régulation transcriptionnelle et maladies génétiques, UFR biomédicale des Saints-Pères, Université Paris V, 45, rue des Saints-Pères, 75270 Paris cedex 6, France. civas@biomedicale.univ-paris5.fr
authors.forename: Ahmet
authors.initials: A
authors.lastname: Civas
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Island
authors.forename: Pierre
authors.initials: P
authors.lastname: Génin
authors.forename: Pierre
authors.initials: P
authors.lastname: Morin
authors.forename: Sébastien
authors.initials: S
authors.lastname: Navarro
mesh_terms: D000818:Animals; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000502:physiology; D015967:Gene Expression Regulation, Viral / Q000502:physiology*; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D050838:Interferon Regulatory Factor-3; D050839:Interferon Regulatory Factor-7; D016898:Interferon-alpha / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D051761:Paired Box Transcription Factors; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D015533:Transcriptional Activation; D014764:Viral Proteins / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C494232:IRF3 protein, human; C494234:IRF7 protein, human; D050838:Interferon Regulatory Factor-3; D050839:Interferon Regulatory Factor-7; D016898:Interferon-alpha; C494233:Irf3 protein, mouse; C494235:Irf7 protein, mouse; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D014764:Viral Proteins; C101485:homeobox protein PITX1