Antithrombotic activity of N,N-dichlorotaurine on mouse model of thrombosis in vivo.
Intravenous injection of chloramine derivatives of amino acids and taurine reduced the mortality rate in mice with thrombosis induced by intravenous injection of ADP or collagen-epinephrine mixture. Intravenous injection of N,N-dichlorotaurine caused 50% inhibition of platelet aggregation induced by ADP and measured in the platelet-enriched plasma in vitro. The antithrombotic effect of chloramine derivatives of amino acids and taurine is related to their ability to suppress functional activity of platelets.
Murina
M A
MA
Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow. marina_murina@mail.ru
Fesenko
O D
OD
Sergienko
V I
VI
Chudina
N A
NA
Roshchupkin
D I
DI
D000244:Adenosine Diphosphate / Q000378:metabolism / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D002700:Chloramines / Q000494:pharmacology*; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010974:Platelet Aggregation; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013927:Thrombosis / Q000188:drug therapy*; D013997:Time Factors
D000596:Amino Acids; D002700:Chloramines; D005343:Fibrinolytic Agents; C454660:N,N-dichlorotaurine; D013654:Taurine; D000244:Adenosine Diphosphate