Review of methods to remove protein-bound substances in liver failure.
A wide range of toxic substances accumulates in the circulation of patients with liver failure, including more lipid-soluble substances, which bind to plasma proteins. Serum albumin is the most important binding protein for ligands such as bilirubin and bile acids, which are potentially toxic and can cause apoptosis in astrocytes and hepatocytes respectively in vitro. Resin haemoperfusion was originally investigated to remove these compounds, as well as inflammatory cytokines. Current effective methods for removal of protein-bound compounds in patients with liver failure include high volume plasmapheresis and different forms of albumin dialysis. Bioartificial liver support systems need adsorbent and/or dialysis modules to replace the lack of excretory function.
Hughes
R D
RD
Institute of Liver Studies, Guy's, King's & St Thomas' School of Medicine, King's College, London, UK. robin.hughes@kcl.ac.uk
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D005112:Extracorporeal Circulation; D006801:Humans; D017093:Liver Failure / Q000378:metabolism / Q000628:therapy*; D019164:Liver, Artificial; D010951:Plasma Exchange; D010956:Plasmapheresis; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D016060:Sorption Detoxification
D001647:Bile Acids and Salts; D012709:Serum Albumin; D001663:Bilirubin