Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: an MRS study.
OBJECTIVE
To help determine the effects of dextro-amphetamine on the phosphoinositol cycle (PI-cycle) in humans, (1)H and (31)P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open-label study carried out before and after administration of 20 mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS).


RESULTS
Following dextro-amphetamine administration there was a significant increase in the concentrations of both myo-inositol and phosphomonoesters.


CONCLUSIONS
These findings are in keeping with suggestions that dextro-amphetamine administration increases the activity of the phosphoinositol cycle, probably via an indirect release of dopamine and noradrenaline. These results are the first time that this has been confirmed in humans.
Silverstone
Peter H
PH
Department of Psychiatry, University Hospital, University of Alberta, Edmonton, Alberta T6G 2B7, Canada. peter.silverstone@ualberta.ca
O'Donnell
Tina
T
Ulrich
Michele
M
Asghar
Sheila
S
Hanstock
Christopher C
CC
D000328:Adult; D000339:Affect / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000494:pharmacology*; D003401:Creatine / Q000378:metabolism; D003913:Dextroamphetamine / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*
D000697:Central Nervous System Stimulants; D010716:Phosphatidylinositols; D007294:Inositol; D003401:Creatine; D003913:Dextroamphetamine