[A graded composite material for use in the area of the cranial and facial skull].
For the reconstruction of complex skull defects with individual prefabricated CAD/CAM-implants titanium is well established as bone substitution material. The aim of our studies was to optimize a composite material from polyesters and calcium phosphate. Therefore two different operating procedures (hot pressing and gas-flushing) were combined. As a result the graded composition and porosity of the implants allow a spatial guided degradation progress and cell ingrowth. First biocompatibility tests in vitro with primary human osteoblasts showed a much better pH-characteristic and a better biocompatibility of the composites in comparison with the pure polymers. Degradation experiments in vitro confirmed the different expected degradation rates of the composite materials. As a next step in vivo experiments in ovine skulls are in progress.
Weihe
S
S
Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Ruhr-Universität Bochum, Deutschland. stephan.weihe@ruhr-uni-bochum.de
Schiller
C
C
Rasche
C
C
Wehmöller
M
M
Eufinger
H
H
Epple
M
M
D000818:Animals; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D017076:Computer-Aided Design; D003399:Craniotomy / Q000379:methods*; D006801:Humans; D019344:Lactic Acid; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology; D011091:Polyesters; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D019919:Prosthesis Implantation; D012756:Sheep
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous