title: Endocrine effects of sublethal exposure to persistent organic pollutants (POPs) on silver carp (Hypophthalmichthys molitrix).
abstract: Silver carp (Hypophthalmichthys molitrix) samples were collected from five selected sites that represent diverse levels of downgraded persistent organic pollutants (POPs) contamination in Ya-Er Lake in October 1999. Hepatic ethoxyresorufin-O-deethylase (EROD) and UDP glucuronosyltransferase (UDPGT) activities, hepatosomatic index (HSI), hepatic retinoids, serum thyroid hormones were measured. It was found that hepatic retinol and serum free 3,5,3'- tetraiodothyronine (FT3) significantly increased (P < 0.01) when both hepatic EROD and UDPGT activities significantly declined (P < 0.01) from pond 1 to 5 with decrease in the degree of pollution. This significant negative correlation (P < 0.01) suggests that the persistent organochlorinated contaminants could induce hepatic EROD and UDPGT activities, alter retinoid and thyroid hormone homeostasis, and finally lead to the reduction of retinol and FT3, the two biologically active forms of retinoids and thyroid hormone in silver carp of Ya-Er Lake.
authors.affiliation: Institute of Hydrobiology, Chinese Academy of Science, Wuhan. xuying@ihb.ac.cn
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: K W
authors.initials: KW
authors.lastname: Schramm
authors.forename: A
authors.initials: A
authors.lastname: Kettrup
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism*; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D004703:Endocrine System / Q000187:drug effects*; D004781:Environmental Exposure; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009930:Organic Chemicals / Q000633:toxicity*; D014284:Triiodothyronine / Q000097:blood; D014801:Vitamin A / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D009930:Organic Chemicals; D014874:Water Pollutants, Chemical; D014284:Triiodothyronine; D014801:Vitamin A; D019363:Cytochrome P-450 CYP1A1; D014453:Glucuronosyltransferase