Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
A series of 5-nitro-2-furancarbohydrazides were synthesized. In vitro antitrypanosomal activities of these compounds were determined against the closely related protozoa Trypanosoma cruzi Trypanosoma brucei and discussed in relation to potential targets.
Millet
Régis
R
UMR 8525 CNRS, Université de Lille 2, Institut de Biologie de Lille et Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 447, France.
Maes
Louis
L
Landry
Valérie
V
Sergheraert
Christian
C
Davioud-Charvet
Elisabeth
E
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D020128:Inhibitory Concentration 50; D018314:Leishmania infantum / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000469:parasitology; D051379:Mice; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects; D014407:Tumor Cells, Cultured
D006834:Hydrazines; D014344:Trypanocidal Agents