Synthesis, crystal structure and initial biological evaluation of the new enantiomerically pure chiral palladium(II) complex trans-bis[endo-(1R)-1,7,7-trimethylbicyclo[2.2.1]-heptan-2-amino]palladium(II)dichloride.
The palladium(II) complex trans-bis[(R)-(+)-bornylamino]palladium(II) dichloride was synthesised and characterised. The solid state structure of the complex was determined by X-ray structure analysis. The compound crystallises in the monoclinic space group P2(1) with a=12.383(2), b=23.689(5), c=12.769(3) A, beta=93.25(3) degrees, and V=3739.6(13) A(3). The complex was tested for its cytotoxicity against L(929), K(562) and HeLa cell lines using the MTT assay technique. It is also tested for its anticomplementary activity using a test that detects complement proteins inhibition. These activities were compared with those of the reference standards, cisplatin, carboplatin and oxaliplatin. The significance of these results is given and discussed.
Abu-Surrah
Adnan S
AS
Department of Chemistry, Hashemite University, PO Box 150459, Zarqa 13115, Jordan. asurrah@hu.edu.jo
Al-Allaf
Talal A K
TA
Rashan
Luay J
LJ
Klinga
Martti
M
Leskelä
Markku
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010165:Palladium