title: Apodemus species mice are reservoir hosts of Borrelia garinii OspA serotype 4 in Switzerland.
abstract: Among Borrelia burgdorferi sensu lato isolates, seven outer surface protein A (OspA) serotypes have been described: serotypes 1 and 2 correspond to B. burgdorferi sensu stricto and Borrelia afzelii, respectively, and serotypes 3 to 7 correspond to Borrelia garinii. In Europe, serotype 4 has never been isolated from Ixodes ricinus ticks until recently, although this serotype has been frequently isolated from cerebrospinal fluid from patients. In Europe, B. afzelii and B. burgdorferi sensu stricto were found associated with rodents and B. garinii was found associated with birds. In this study, the reservoir role of Apodemus mice for B. garinii OspA serotype 4 was demonstrated by xenodiagnosis. Apodemus mice are the first identified reservoir hosts for B. garinii OspA serotype 4.
authors.affiliation: Institut de Zoologie, University of Neuchâtel, Neuchâtel, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Huegli
authors.forename: C M
authors.initials: CM
authors.lastname: Hu
authors.forename: P-F
authors.initials: PF
authors.lastname: Humair
authors.forename: B
authors.initials: B
authors.lastname: Wilske
authors.forename: L
authors.initials: L
authors.lastname: Gern
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001428:Bacterial Vaccines; D015748:Borrelia burgdorferi Group / Q000145:classification* / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000032:analysis / Q000737:chemistry; D004197:Disease Reservoirs; D018884:Ixodes / Q000382:microbiology*; D008074:Lipoproteins; D009115:Muridae / Q000382:microbiology*; D012703:Serotyping; D013557:Switzerland
chemical_list: D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D004269:DNA, Bacterial; D008074:Lipoproteins; C072045:OspA protein