title: Do chemokines spark autoimmunity in juvenile and adult rheumatic disease?
abstract: The recent increase in knowledge on chemokines contributes substantially to the understanding of autoimmune inflammatory diseases, as cell migration is an essential prerequisite for the local immune reaction. The purpose of this review is to summarize the essential functions of chemokines in immune activation and to examine their role(s) in the initiation and perpetuation of autoimmunity in juvenile idiopathic arthritis and adult rheumatic disease. The possible relevance of chemokines as therapeutical targets will be discussed.
authors.affiliation: Department of Laboratory Medicine, University of Graz, Austria. harald-mangge@uni-graz.at
authors.forename: Harald
authors.initials: H
authors.lastname: Mangge
authors.forename: Jelena
authors.initials: J
authors.lastname: Vojinovic
authors.forename: Konrad
authors.initials: K
authors.lastname: Schauenstein
mesh_terms: D000328:Adult; D001171:Arthritis, Juvenile / Q000209:etiology / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000276:immunology*; D015551:Autoimmunity; D018925:Chemokines / Q000276:immunology*; D002648:Child; D006801:Humans; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000276:immunology
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine