title: Secretion rate from minor salivary glands in patients with malignant haematological diseases receiving chemotherapy--a pilot study.
abstract: The aim of this pilot study was to investigate the secretion rate from minor salivary glands in 16 patients (mean age 62 years) with myeloma, lymphoma or other malignant haematological diseases receiving chemotherapy (study group). An age- and sex-matched control group (n = 16) was recruited. The secretion rate from the minor salivary glands on the inside of the lower lip, measured using the Periotron method, was in mean 2.8 microliters/cm2/min in the study group compared with 4.5 microliters/cm2/min in the control group (p < 0.01). No difference was found in the secretion rate of paraffin-stimulated whole saliva. There were more individuals who experienced dry mouth in the study group (n = 7) than in the control group (n = 2). The conclusion from this pilot study is that the secretion rate from the minor salivary glands might be reduced in cancer patients treated with chemotherapy.
authors.affiliation: Clinic for Oral Medicine, Public Dental Service, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden. johan.blomgren@vgregion.se
authors.forename: Johan
authors.initials: J
authors.lastname: Blomgren
authors.forename: Sigbritt
authors.initials: S
authors.lastname: Jansson
authors.forename: Stig
authors.initials: S
authors.lastname: Rödjer
authors.forename: Dowen
authors.initials: D
authors.lastname: Birkhed
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008046:Lip; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy; D010865:Pilot Projects; D012463:Saliva / Q000378:metabolism*; D012470:Salivary Glands, Minor / Q000187:drug effects* / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D018709:Statistics, Nonparametric; D014987:Xerostomia / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents