title: Catalytic Leuckart-Wallach-type reductive amination of ketones.
abstract: A CpRh(III) complex catalyzes reductive amination of ketones using HCOONH(4) at 50-70 degrees C to give the corresponding primary amines in high yields. The reaction is clean and operationally simple and proceeds at a lower temperature and with higher chemoselectivity than the original Leuckart-Wallach reaction. The new method has been applied to the synthesis of alpha-amino acids directly from alpha-keto acids.
authors.affiliation: Research Center for Materials Science and the Department of Chemistry, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Kitamura
authors.forename: Donghyun
authors.initials: D
authors.lastname: Lee
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Hayashi
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshimura