Chemokine receptors associated with immunity within and outside the central nervous system in early relapsing-remitting multiple sclerosis.
Thirty-four patients with early relapsing-remitting multiple sclerosis (RRMS) were studied to clarify the differences in chemokine receptor usage by blood and cerebrospinal fluid (CSF) lymphocytes relevant to the pathogenesis of MS. A total of 45 examinations (33 active and 12 inactive stages) revealed that circulating CD4+CXCR3+ T helper 1 (Th1) cells were increased in active MS patients and correlated with the number of gadolinium-enhanced lesions on magnetic resonance (MR) images. In contrast, CSF samples obtained during active stages were characterized by a decrease in the percentage of CD8+CXCR3+ T cells, which was inversely correlated with CSF cell count and intra-blood-brain barrier (BBB) IgG production.
Wang
Hui-Yun
HY
Department of Neurology and Clinical Research Center, Center for Neurological Diseases, Utano National Hospital, Ukyo, Kyoto 616-8255, Japan.
Matsui
Makoto
M
Araya
Shin-ichi
S
Onai
Nobuyuki
N
Matsushima
Kouji
K
Saida
Takahiko
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000954:Antigens, Surface / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D018925:Chemokines / Q000276:immunology*; D005260:Female; D006801:Humans; D007109:Immunity / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D011237:Predictive Value of Tests; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000097:blood / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology
D000954:Antigens, Surface; D015704:CD4 Antigens; D016827:CD8 Antigens; C515187:CXCR3 protein, human; D018925:Chemokines; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine