Cellular molecular based research.
In recent years significant progress has been made in identifying genetic alterations in glial brain neoplasms. Nowadays, three types of development to glioblastoma multiforme (the most malignant form of primary brain tumours) can be identified using genetic molecular techniques. Moreover, with these techniques patients can be identified who will respond to the treatment with alkylating cytostatic drugs. Future research on the genome level but in particular on the level of gene expression holds promise for better grading systems, tailored treatment based on genetic profiling and new targets for treatment. In this paper the history of genetic research on glioma and the techniques that are used are briefly reviewed.
Leenstra
S
S
Department of Neurosurgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
D001932:Brain Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005544:Forecasting; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D036281:Genetic Research; D005909:Glioblastoma / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D005910:Glioma / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D006801:Humans; D009446:Neurobiology / Q000639:trends*; D009493:Neurosurgery / Q000639:trends*