Induction of MHC class II antigens on cells of the inner ear.
Growing evidence supports the concept that immune reactions occur in the cochlea, where they can function either in protection or as a source of inflammation. Since immunity is generally initiated by antigen presentation of foreign substances to T cells, antigen-presenting cells expressing major histocompatibility complex (MHC) class II molecules are required. Under resting conditions, cochlear cells usually express no MHC class II. However, we show that exposure to -interferon in vitro induces an increase in MHC class II expression in neonatal cochlear cells of mice. In addition, MHC class II immunoreactivity was observed in the inner ear of adult mice after induction of sterile labyrinthitis in vivo. It is concluded that the induction of MHC class II molecules by inflammation may render cochlear cells competent to initiate and participate in immune reactions and may therefore contribute to both immunoprotective and immunopathological responses of the inner ear.
Gloddek
Bertrand
B
Department of Surgery, Division of Otolaryngology and Neuroscience, UCSD School of Medicine, La Jolla, Calif 92093-0666, USA.
Bodmer
Daniel
D
Brors
Dominik
D
Keithley
Elizabeth M
EM
Ryan
Allen F
AF
D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D000998:Antiviral Agents / Q000494:pharmacology; D002478:Cells, Cultured; D003051:Cochlea / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005434:Flow Cytometry / Q000379:methods; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism; D006681:HLA-D Antigens / Q000276:immunology*; D007371:Interferon-gamma / Q000494:pharmacology; D007762:Labyrinthitis / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D009925:Organ of Corti / Q000187:drug effects / Q000276:immunology; D013136:Spiral Ganglion / Q000187:drug effects / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D015703:Antigens, CD; D000998:Antiviral Agents; D006023:Glycoproteins; D006681:HLA-D Antigens; D007371:Interferon-gamma