Effects of the neuropeptide substance P on sleep, mood, and neuroendocrine measures in healthy young men.
The neuropeptide substance P (SP) has been supposed to be involved in the etiopathology of affective disorders, mainly because of the finding of increased levels of SP in the cerebrospinal fluid of depressed patients and the preliminary evidence of antidepressant effects of SP-receptor antagonists in depressed patients. We investigated whether SP may induce changes of sleep, mood and neuroendocrine measures that are similar to those in depressed patients. In a double-blind, randomized cross-over design, 12 healthy young men were investigated in two blocks of three consecutive nights, in which SP or NaCl was intravenously infused during the third night. Polysomnographic recordings were obtained during all nights and blood samples were drawn every 30 min during the third night. Infusion of SP caused a significant worsening of the mood of the subjects, led to an increase of REM latency and time awake during the SP-infusion intervals, caused increased stage 1 sleep in the first part of the night, and led to increased cortisol and thyroid stimulating hormone levels and a trend for decreased growth hormone levels. These effects can be interpreted as evidence for a central arousing effect of SP. Further studies should focus on the effects of substance P in patients with depressive or other psychiatric disorders.
Lieb
Klaus
K
Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr. 5, D-79104 Freiburg, Germany. klaus_lieb@psyallg.ukl.uni-freiburg.de
Ahlvers
Katrin
K
Dancker
Katharina
K
Strohbusch
Stefan
S
Reincke
Martin
M
Feige
Bernd
B
Berger
Mathias
M
Riemann
Dieter
D
Voderholzer
Ulrich
U
D000328:Adult; D000339:Affect / Q000187:drug effects* / Q000502:physiology; D019540:Area Under Curve; D018592:Cross-Over Studies; D004311:Double-Blind Method; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007262:Infusions, Intravenous; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000502:physiology; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D018709:Statistics, Nonparametric; D013373:Substance P / Q000494:pharmacology* / Q000502:physiology; D013972:Thyrotropin / Q000097:blood
D009479:Neuropeptides; D013373:Substance P; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone