New saponins from the starfish Certonardoa semiregularis.
Ten new saponins designated as certonardosides A-J (1-5, 7-11) and the known halityloside D (6) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis and chemical manipulation. The compounds were evaluated for antiviral activity against HIV, HSV, CoxB, EMCV, and VSV and displayed insignificant activity within the range of noncytotoxic concentrations.
Wang
Weihong
W
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Li
Famei
F
Alam
Naseer
N
Liu
Yonghong
Y
Hong
Jongki
J
Lee
Chong-Kyo
CK
Im
Kwang Sik
KS
Jung
Jee H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013215:Starfish / Q000737:chemistry*; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D012503:Saponins; D013256:Steroids; C471535:halityloside D