uvsZ1 mutation shows epistatic relations with uvsD153 and uvsJ1 mutations without any involvement with checkpoint control in Aspergillus nidulans.
The participation of the recently described uvsZ1 mutation in checkpoint control and the identification of epistatic relations between uvsZ1 mutation and uvsD153 and uvsJ1 mutations are provided. The effect of mutation uvsZ1 in mitotic exchanges into paba-bi (chromosome I) and cho-nic (chromosome VII) genetic intervals has also been evaluated. The mutation uvsZ1 was epistatic with regard to uvsD153 and uvsJ1 mutations, with no involvement with checkpoint control. In contrast to mutations in UvsB and UvsF groups, the uvsZ1 mutation failed to cause any changes in the frequencies of mitotic crossing-over. The distinct phenotypic traits given by mutation uvsZ1 suggest the presence of complex interactions among the different DNA repair pathways. Interaction may be an additional cell strategy of DNA damage response.
Baptista
Francielle
F
Universidade Estadual de Maringá, Departamento de Biologia Celular e Genética, Avenida Colombo, 5790, 87020-900, Maringá PR Brasil. maacprado@uem.br
de Castro-Prado
Marialba Avezum Alves
MA
D001233:Aspergillus nidulans / Q000235:genetics*; D003434:Crossing Over, Genetic; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics; D004843:Epistasis, Genetic; D005800:Genes, Fungal; D009154:Mutation / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics; D014466:Ultraviolet Rays
D004271:DNA, Fungal