title: Construction of the simplest model to explain complex receptor activation kinetics.
abstract: We study the mathematical solutions to the kinetic equations arising from various simple ligand-receptor [corrected] models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exhibit features observed in some experiments, most noticeably a distinct maximum in the activity curve.
authors.affiliation: Biostructure Department, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.
authors.forename: R P
authors.initials: RP
authors.lastname: Bywater
authors.forename: A
authors.initials: A
authors.lastname: Sørensen
authors.forename: P
authors.initials: P
authors.lastname: Røgen
authors.forename: P G
authors.initials: PG
authors.lastname: Hjorth
mesh_terms: D000818:Animals; D001711:Biotransformation; D008024:Ligands; D008954:Models, Biological; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D008024:Ligands; D011956:Receptors, Cell Surface