Structural and topical bases of picrotoxin-induced choreomyoclonic hyperkinesis.
Multiple bilateral microinjections of 1  g picrotoxin (blocker of GABAA-receptor chlorine channels) into the rostral neostriatum cause choreomyoclonic hyperkinesis of the paws, head, and body in rats. The most pronounced hyperkinesis was observed when the cannula was localized in the most anterior regions of the rostral neostriatum with irradiation of its action to the white matter (corpus callosum) and when the cannulas were located asymmetrically in the right and left striatum.
Yakimovskii
A F
AF
Department of Normal Physiology, I. P. Pavlov St. Petersburg State Medical University, St. Petersburg. jakim@spmu.rssi.ru
D000818:Animals; D006948:Hyperkinesis / Q000139:chemically induced*; D008297:Male; D017072:Neostriatum; D010852:Picrotoxin / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D010852:Picrotoxin