Phagocytosis and the microtubule cytoskeleton.
Phagocytosis is a critical host defense mechanism used by macrophages and neutrophils to clear invading pathogens. The complex sequence of events resulting in internalization and degradation of the pathogens is a coordinated process involving lipids, signaling proteins, and the cytoskeleton. Here, we examine the role of the microtubule cytoskeleton in supporting both the engulfment of pathogens and their elimination within phagolysosomes.
Harrison
Rene E
RE
Division of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Grinstein
Sergio
S
D000818:Animals; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000502:physiology*; D008954:Models, Biological; D010587:Phagocytosis; D010588:Phagosomes / Q000502:physiology; D015398:Signal Transduction