Brca1 and differentiation.
Breast cancer is one of the most frequent malignancies affecting women. The human breast cancer gene 1 (BRCA1) gene is mutated in a distinct proportion of hereditary breast and ovarian cancers. Tumourigenesis in individuals with germline BRCA1 mutations requires somatic inactivation of the remaining wild-type allelle. Although, this evidence supports a role for BRCA1 as a tumour suppressor, the mechanisms through which its loss leads to tumourigenesis remain to be determined. Neither the expression pattern nor the described functions of human BRCA1 and murine breast cancer gene 1 (Brca1) can explain the specific association of mutations in this gene with the development of breast and ovarian cancer. Investigation of the role of Brca1 in normal cell differentiation processes might provide the basis to understand the tissue-restricted properties.
Kubista
Marion
M
AKH-EBO-E6 Division of Prenatal Diagnosis and Therapy, Obstetrics and Gynecology, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria.
Rosner
Margit
M
Miloloza
Angelina
A
Hofer
Katja
K
Prusa
Andrea-Romana
AR
Kroiss
Regina
R
Marton
Erika
E
Hengstschläger
Markus
M
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D019398:Genes, BRCA1; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D011960:Receptors, Estrogen