title: Acid-promoted DNA-cleaving activities and total synthesis of varacin C.
abstract: The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.
authors.affiliation: Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Alex H F
authors.initials: AH
authors.lastname: Lee
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Liu
authors.forename: Thomas Y C
authors.initials: TY
authors.lastname: Leung
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
authors.forename: Tianhu
authors.initials: T
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology; D004249:DNA Damage; D004270:DNA, Circular / Q000187:drug effects* / Q000378:metabolism; D004278:DNA, Superhelical / Q000187:drug effects* / Q000378:metabolism; D004347:Drug Interactions; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013440:Sulfides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004270:DNA, Circular; D004278:DNA, Superhelical; D005021:Ethylamines; D013438:Sulfhydryl Compounds; D013440:Sulfides; C093887:varacin C