Mouse models of Charcot-Marie-Tooth disease.
A common peripheral neuropathy, Charcot-Marie-Tooth disease, progressively develops with distal muscle atrophy. Several genes expressed in Schwann cells and neurons have been identified to be responsible for this hereditary disease, and used in generating transgenic and knockout mice. Such mice are good disease models for cell biological and therapeutic studies.
Tanaka
Yosuke
Y
Dept of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, 113-0033, Tokyo, Japan.
Hirokawa
Nobutaka
N
D000818:Animals; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005544:Forecasting; D016547:Kinesins / Q000235:genetics / Q000502:physiology; D051379:Mice; D009185:Myelin Proteins / Q000235:genetics / Q000502:physiology; D009186:Myelin Sheath / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D016900:Neurofilament Proteins / Q000235:genetics / Q000502:physiology; D009474:Neurons / Q000473:pathology / Q000502:physiology; D012583:Schwann Cells / Q000473:pathology / Q000502:physiology
C490398:Kif1b protein, mouse; D009185:Myelin Proteins; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; C489545:Pmp22 protein, mouse; C044882:neurofilament protein L; D016547:Kinesins