Checking on the fork: the DNA-replication stress-response pathway.
To ensure the fidelity of DNA replication, cells activate a stress-response pathway when DNA replication is perturbed. This pathway regulates not only progress through the cell cycle but also transcription, apoptosis, DNA repair/recombination and DNA replication itself. Mounting evidence has suggested that this pathway is important for the maintenance of genomic integrity. Here, we discuss recent findings about how this pathway is activated by replication stress and how it regulates the DNA-replication machinery to alleviate the stress.
Osborn
Alexander J
AJ
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, TX 77030, USA.
Elledge
Stephen J
SJ
Zou
Lee
L
D000818:Animals; D004261:DNA Replication / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D018816:Genes, cdc / Q000502:physiology*; D016196:S Phase / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015003:Yeasts / Q000502:physiology