[Modern aspects of investigation and clinical application of glutamatergic agents].
The paper considers the main trends in development and summarizes the results of experimental and clinical investigations of glutamatergic drugs, including the glutamate synthesis and release inhibitors, NMDA receptor antagonists, AMPA receptor antagonists and positive modulants, and metabotropic glutamate receptors ligands.
Petrov
V I
VI
Institute of Pharmacology, Volgograd State Medical Academy, Ministry of Public Health of the Russian Federation, pl. Pavshikh Bortsov 1, Volgograd, 400131 Russia.
Onishchenko
N V
NV
D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D018091:Receptors, AMPA; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate