Renal injury from valproic acid: case report and literature review.
A child with developmental delay and epilepsy developed glucosuria approximately 16 months after starting valproic acid therapy. Laboratory evaluation revealed global defects in proximal tubule function consistent with the De Toni-Debré-Fanconi syndrome. Discontinuation of valproate led to complete recovery 5 months later. Review of previously reported cases indicates that this complication is unique to children and reversible when the medication is discontinued.
Zaki
Emad L
EL
Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo and The Children's Hospital, Buffalo, New York 14222, USA.
Springate
James E
JE
D002648:Child; D004832:Epilepsy, Absence / Q000188:drug therapy; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D014635:Valproic Acid / Q000009:adverse effects*
D014635:Valproic Acid