Estrogens in female thyroid cancer: alteration of urinary profiles in pre- and post-operative cases.
To evaluate the potential effect of estrogens in premenopausal female thyroid cancer, the concentrations of 14 estrogens were quantitatively determined in the urine of pre- and post-operative patients with thyroid papillary cancer (18 patients case, 26 approximately 54 years) and normal female subjects (20 cases, 31 approximately 52 years). The highly sensitive gas chromatography-mass spectrometry-selected ion-monitoring method was used for estrogens analysis. And an estrogen-oxidative metabolism and 16alpha-hydroxyestrone to 2-hydroxyestrone (16alpha-OH E1/2-OH E1) which is the two primary and competing site of estrogen-oxidation, were determined. Catechol estrogens, including 2-OH E1, were also increased without significant changes of the other estrogen metabolites in pre-operative patients with thyroid papillary cancer compared with normal subjects. The lowest mean value of 16alpha-OH E1/2-OH E1 was remarked in pre-operative patients, and it was significantly different from the ratio of post-operative cases. As a result, it is suggested that the increase of 2-hydroxylation in estrogen metabolism may have a significant association with female thyroid cancer.
Lee
Seon Hwa
SH
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul, 130-650, South Korea.
Kim
Kyung Mee
KM
Jung
Byung Hwa
BH
Chung
Woung Youn
WY
Park
Cheong Soo
CS
Chung
Bong Chul
BC
D000328:Adult; D004967:Estrogens / Q000652:urine*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000652:urine; D008875:Middle Aged; D011184:Postoperative Period; D013964:Thyroid Neoplasms / Q000601:surgery / Q000652:urine*
D004967:Estrogens; D006894:Hydroxyestrones; C026702:16-hydroxyestrone