title: Maldigestion and malabsorption of dietary lipid during severe childhood malnutrition.
abstract: BACKGROUND
  Diets rich in lipid are used to provide energy density in treating children with severe malnutrition, but the extent to which their digestion and absorption can cope with the load effectively is uncertain.
  
  
  OBJECTIVE
  To determine the extent of impaired digestion or absorption, in three groups of eight malnourished children (aged 5-23 months) using isotopic probes of the predominant fatty acids in coconut and corn oil used to fortify the diet.
  
  
  METHODS
  Each child received oral doses of one of three (13)C labelled triglycerides (trilaurin, triolein, or trilinolein). The recovery of (13)C label in stool either as triglyceride (TAG) or fatty acid (FA), was used to assess digestion and absorption. In a separate test, the recovery of label in stool following an oral dose of [(13)C]-glycocholate was measured to assess bile salt malabsorption.
  
  
  RESULTS
  The median recovery of label in stool was 9% (range 1-29%) of administered dose. Following treatment there was a reduction in stool (13)C excretion for the labelled TAG (<1%). In half the subjects, label was recovered as TAG in stool (median 0.6%, range 0-44%). Most label in stool was recovered as FA (median 30%, range 0-100%). Following [(13)C]-glycocholate, label was recovered in excess in about one third of studies.
  
  
  CONCLUSIONS
  Abnormalities in the gastrointestinal handling of lipid were observed in over 50% of children with severe malnutrition, reflecting problems in absorption, although impaired solubilisation or hydrolysis could also be contributory factors. The underlying lesion improves as treatment progresses, leading to concomitant improvement in function.
authors.affiliation: The Institute of Human Nutrition, University of Southampton, Southampton, UK. jlmurphy@soton.ac.uk
authors.forename: J L
authors.initials: JL
authors.lastname: Murphy
authors.forename: A V
authors.initials: AV
authors.lastname: Badaloo
authors.forename: B
authors.initials: B
authors.lastname: Chambers
authors.forename: T E
authors.initials: TE
authors.lastname: Forrester
authors.forename: S A
authors.initials: SA
authors.lastname: Wootton
authors.forename: A A
authors.initials: AA
authors.lastname: Jackson
mesh_terms: D002247:Carbon Isotopes; D004032:Diet; D004063:Digestion / Q000502:physiology*; D004064:Digestive System / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006000:Glycocholic Acid / Q000378:metabolism; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000378:metabolism*; D050356:Lipid Metabolism; D008286:Malabsorption Syndromes / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D002247:Carbon Isotopes; D005227:Fatty Acids; D014280:Triglycerides; D006000:Glycocholic Acid