title: Cell proliferation and expression of Cbfa-1 in a peripheral osteo-chondroma arising from the mandibular oral mucosa of an edentulous alveolar ridge.
abstract: This report describes the proliferation and the expression of Cbfa-1 in a rare case of peripheral osteo-chondroma arising from the mandibular oral mucosa of an edentulous alveolar ridge. Histologically, the lesion consisted of mesenchymal cells with either bone or cartilage tissue in the center. Almost all the tumor cells were reactive for PCNA, however, only the cells around the bone and cartilage tissues were reactive for Cbfa-1. These results suggest that both the bone and the cartilage tissues in this case were produced by mesenchymal cells that originated from the peripheral periosteum of the alveolar ridge. Furthermore, we have shown that immunohistochemical staining for PCNA and Cbfa-1 can be used to investigate lesions with bone or cartilage formation and to distinguish between those produced by osteogenic cells from those that are just reactive and produced by dystrophic calcification.
authors.affiliation: Department of Clinical Pathophysiology, Oral Health Science Center, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuzaka
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hayashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sasaguri
authors.forename: Sadao
authors.initials: S
authors.lastname: Sato
authors.forename: Kyoto
authors.initials: K
authors.lastname: Takemoto
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimono
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000368:Aged; D000539:Alveolar Process / Q000473:pathology; D002455:Cell Division; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007575:Jaw, Edentulous / Q000150:complications; D008339:Mandibular Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009363:Neoplasm Proteins; D010006:Osteoblasts / Q000473:pathology; D015831:Osteochondroma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: D009363:Neoplasm Proteins; D018809:Proliferating Cell Nuclear Antigen; D014157:Transcription Factors