title: Synthesis of (25R)-26-hydroxycholesterol.
abstract: We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction.
authors.affiliation: Department of Chemistry, Temple University, 13th & Norris Streets, Beury Hall (016-00), Philadelphia, PA 19122-2585, USA. john.r.williams@temple.edu
authors.forename: John R
authors.initials: JR
authors.lastname: Williams
authors.forename: Deping
authors.initials: D
authors.lastname: Chai
authors.forename: Dominic
authors.initials: D
authors.lastname: Wright
mesh_terms: D006888:Hydroxycholesterols / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D006888:Hydroxycholesterols; C007042:cholest-5-ene-3 beta,26-diol