title: Urine microalbumin excretion in relation to exercise-induced electrocardiographic myocardial ischaemia.
abstract: BACKGROUND
  Microalbuminuria, a marker of endothelial cell dysfunction, is associated with atherosclerosis and is a predictor of coronary heart disease. It has been suggested that patients with coronary heart disease have exaggerated exercise-induced urinary microalbumin excretion but this is controversial. We, therefore, measured urine microalbumin excretion in men before and after an exercise electrocardiogram.
  
  
  METHODS
  Urine microalbumin excretion expressed as the albumin-creatinine ratio (ACR) was measured before and after an exercise electrocardiogram in 10 subjects with exercise-induced myocardial ischaemia and 14 subjects without exercise-induced myocardial ischaemia.
  
  
  RESULTS
  In subjects with a positive exercise electrocardiogram, the pre-exercise electrocardiogram ACR 3.3 +/- 5.50; (mean+/-SD) significantly increased (p=0.0371) following exercise (6.30 +/-10.25). In subjects with a negative exercise electrocardiogram, the pre-exercise electrocardiogram ACR (0.73 +/-0.52) also significantly increased (p=0.0295) following exercise (2.04 +/-1.81). Pre-exercise ACR was higher (p=0.0164) in subjects with a positive exercise electrocardiogram (3.3 +/-5.50) than in those subjects with a negative exercise electrocardiogram (0.73 +/-0.52). Incremental and post-exercise ACR were not significantly different in those with normal and abnormal exercise electrocardiograms.
  
  
  CONCLUSIONS
  Patients with exercise-induced myocardial ischaemia have pre-exercise urine microalbumin excretion. Exaggerated urine microalbumin excretion in response to exercise is not associated with exercise-induced myocardial ischaemia.
authors.affiliation: Department of Clinical Chemistry, New Cross Hospital, Wolverhampton, West Midlands, UK.
authors.forename: Julian S
authors.initials: JS
authors.lastname: Waldron
authors.forename: Yetunde
authors.initials: Y
authors.lastname: Baoku
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hartland
authors.forename: Neil R
authors.initials: NR
authors.lastname: Anderson
authors.forename: Richard
authors.initials: R
authors.lastname: Horton
authors.forename: Rousseau
authors.initials: R
authors.lastname: Gama
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000209:etiology*; D003324:Coronary Artery Disease / Q000628:therapy; D004562:Electrocardiography; D015444:Exercise; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia; D013997:Time Factors