title: [Diagnosis of hepatocellular carcinoma with bone metastasis using fine needle aspiration biopsy: report of 2 cases].
abstract: The clinical presentations and imaging characteristics of hepatocellular carcinoma (HCC) are usually various and complex. This article reported 2 cases of HCC with the initial symptoms being bone metastasis that did not exhibit typical clinical manifestations or distinct feature in liver imaging, without elevated serum alpha-fetoprotein. The diagnoses were certified by fine needle aspiration biopsy, which is recommended for differential diagnosis in cases of complex HCC with bone metastasis, to avoid liver biopsy and surgical bone biopsy.
authors.affiliation: Institute of Digestive Disease of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. dan@fimmu.edu.cn
authors.forename: Han-Lei
authors.initials: HL
authors.lastname: Dan
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Ji-Ren
authors.initials: JR
authors.lastname: Zhang
authors.forename: Zheng-Shu
authors.initials: ZS
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis