title: Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation.
abstract: Proton magnetic resonance spectroscopy (MRS) revealed a distinct resonance at 3.15 ppm in the brain of a 5-year-old male diagnosed with autism. The resonance assignment is attributable to ingestion of methylsulfonylmethane (MSM) as a dietary supplement. Glucosamine with MSM is marketed as a source of dietary sulfur and treatment of joint pain. Recognition of this chemical on brain proton MRS as an exogenous compound is necessary to avoid confusion as a pathologic metabolite of pediatric metabolic disease.
authors.affiliation: Department of Radiology/MC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. cecil@athena.chmcc.org
authors.forename: Kim M
authors.initials: KM
authors.lastname: Cecil
authors.forename: Alexander
authors.initials: A
authors.lastname: Lin
authors.forename: Brian D
authors.initials: BD
authors.lastname: Ross
authors.forename: John C
authors.initials: JC
authors.lastname: Egelhoff
mesh_terms: D001321:Autistic Disorder / Q000378:metabolism*; D002675:Child, Preschool; D019587:Dietary Supplements; D004121:Dimethyl Sulfoxide; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013450:Sulfones / Q000378:metabolism*
chemical_list: D013450:Sulfones; C025910:dimethyl sulfone; D004121:Dimethyl Sulfoxide