title: Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands.
abstract: A new synthetic methodology to provide cis-2-(1H-imidazol-4-yl)-cyclopropane carboxylic acids is described. These cyclopropanes are useful for the preparation of novel H(3) receptor agents.
authors.affiliation: Departamento de Ciencias Qui;micas, Sección de Qui;mica Orgánica y Farmacéutica, Universidad San Pablo CEU, Urb Montepríncipe, Boadilla del Monte 28668, Madrid, Spain. mfbrana@ceu.es
authors.forename: Miguel F
authors.initials: MF
authors.lastname: Braña
authors.forename: Cristina
authors.initials: C
authors.lastname: Guisado
authors.forename: Luis
authors.initials: L
authors.lastname: Fernando Alguacil
authors.forename: Elisa
authors.initials: E
authors.lastname: Garrido
authors.forename: Carmen
authors.initials: C
authors.lastname: Pérez-García
authors.forename: Mariano
authors.initials: M
authors.lastname: Ruiz-Gayo
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000494:pharmacology; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008761:Methylhistamines / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D002264:Carboxylic Acids; D003521:Cyclopropanes; D006633:Histamine Antagonists; D008024:Ligands; D008761:Methylhistamines; D018100:Receptors, Histamine H3