title: Cognitive epilepsy: ADHD related to focal EEG discharges.
abstract: This study was undertaken to determine the effect of antiepileptic treatment on a child with attention-deficit-hyperactivity disorder and subclinical electroencephalographic discharges without seizures. We performed a longitudinal follow-up study correlating clinical, neuropsychologic, and electroencephalographic features with antiepileptic drug therapy. The results revealed a temporal relation between subclinical epileptiform discharges and cognitive dysfunction and a significant effectiveness of antiepileptic drugs on attention-deficit-hyperactivity disorder and electroencephalographic discharges. The practice of monitoring antiepileptic treatment limited to seizure control should be revised; cognitive impairments also need to be taken into account even without occurrence of seizure. The classical principle of treating only seizures needs to be reconsidered.
authors.affiliation: Department of Pediatric Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Nicole
authors.initials: N
authors.lastname: Laporte
authors.forename: Guillaume
authors.initials: G
authors.lastname: Sébire
authors.forename: Yves
authors.initials: Y
authors.lastname: Gillerot
authors.forename: Renzo
authors.initials: R
authors.lastname: Guerrini
authors.forename: Sophie
authors.initials: S
authors.lastname: Ghariani
mesh_terms: D000932:Antiemetics / Q000494:pharmacology / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects / Q000706:statistics & numerical data; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans
chemical_list: D000932:Antiemetics