Modulation of tumor growth by crossreacting isoantibodies.
Tumor cells transfected with strong antigenic epitopes were able to stimulate humoral response against relevant wild-type tumors. Crossreacting immune sera have been obtained by immunizing C57BL/6 mice with OVA-transfected leukemia EL-4 (subclone E.G7) and OVA-transfected melanoma B16 (subclone MO.5) stimulated with interferon-gamma. Tumors were significantly inhibited when antisera were injected subcutaneously close to the site of solid wild-type tumors EL-4 and B16 grafted onto C57BL/6 mice.
Van Binh
P Nguyen
PN
Inserm U268, InstitutAndré-Lwoff Hĵpital Paul-Brousse, Villejuif, France.
Lone
Y S
YS
Duc
H Thien
HT
D000818:Animals; D000917:Antibody Formation; D003429:Cross Reactions; D019084:Fluorescent Antibody Technique, Indirect; D007942:Leukemia, Experimental / Q000276:immunology / Q000473:pathology*; D008545:Melanoma / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000235:genetics / Q000276:immunology; D014407:Tumor Cells, Cultured
D010047:Ovalbumin