title: Nanjiols A-C, new steroids from the Chinese soft coral Nephthea bayeri.
abstract: Three new polyoxygenated steroids, nanjiol A (1), B (2), and C (3), were isolated from an East China Sea soft coral Nephthea bayeri, and their structures were characterized by spectroscopic methods and comparison with known compounds. The new molecules were structurally related to (20S)-cholesta-1,4-diene-18,20-diol-3-one (4), a typical metabolite from the black coral Antipathes subpinnata.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China.
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Shao
authors.forename: Da-Yuan
authors.initials: DY
authors.lastname: Zhu
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular; D002681:China; D004354:Drug Screening Assays, Antitumor; D004578:Electron Spin Resonance Spectroscopy; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007951:Leukemia, Myeloid; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids; C471754:nanjiol A; C471756:nanjiol B; C471755:nanjiol C