Synthesis of potential anti-HIV GP120 inhibitors using a lysine template.
Various acylated proteins have been reported in the literature to possess anti-HIV activity. Described here is the preparation of lysine monomers, dimers and trimers acylated with various anhydrides and dioxalanones as simplified mimics of the acylated proteins. Compounds were assayed against HIV-infected C8166 cells and some showed weak anti-HIV activity.
Doyl
Valerie E
VE
Klimkait
Thomas
T
Mahmood
Naheed
N
Slater
Martin
M
Hazen
Richard J
RJ
Gilbert
Ian H
IH
D000215:Acylation; D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D008239:Lysine / Q000737:chemistry* / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D015699:HIV Envelope Protein gp120; D009842:Oligopeptides; D008239:Lysine