Effect of mitomycin C on distribution of chromatid exchanges and their dose dependency in resting human lymphocytes.
Cells distribution by the number of chromatid exchanges induced by mitomycin C corresponds to geometric distribution. The dependences of the number of chromatid exchanges and the number of fragments on the dose of the mutagen are described by exponential and linear curves, respectively. Quantitative regularities of mitomycin C-induced chromosome aberrations correspond to those of "monocentric" mutagens.
Kosyakova
N V
NV
Medico-Genetic Center, Russian Academy of Medical Sciences. righthere@mail.ru
Chebotarev
A N
AN
D000477:Alkylating Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016685:Mitomycin / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D016192:Resting Phase, Cell Cycle; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000477:Alkylating Agents; D009153:Mutagens; D016685:Mitomycin