title: The impact of a cardioprotective protocol on the incidence of cardiac complications after aortic abdominal surgery.
abstract: We analyzed a local database including 468 consecutive patients who underwent elective aortic abdominal surgery over an 8-yr period in a single institution. A new cardioprotective perioperative protocol was introduced in January 1997, and we questioned whether perioperative cardiac outcome could be favorably influenced by the application of a stepwise cardiovascular evaluation based on the American College of Cardiology/American Heart Association guidelines and by the use of antiadrenergic drugs. Clonidine was administered during surgery, and beta-blockers were titrated after surgery to achieve heart rates less than 80 bpm. We compared data of two consecutive 4-yr periods (1993-1996 [control period] versus 1997-2000 [intervention period]). Implementation of American College of Cardiology/American Heart Association guidelines was associated with increased preoperative myocardial scanning (44.3% vs 20.6%; P < 0.05) and coronary revascularization (7.7% vs 0.8%; P < 0.05). During the intervention period, there was a significant decrease in the incidence of cardiac complications (from 11.3% to 4.5%) and an increase in event-free survival at 1 yr after surgery (from 91.3% to 98.2%). Multivariate regression analysis showed that the combined administration of clonidine and beta-blockers was associated with a decreased risk of cardiovascular events (odds ratio, 0.3; 95% confidence interval, 0.1-0.8), whereas major bleeding, renal insufficiency, and chronic obstructive pulmonary disease were predictive of cardiac complications. In conclusion, cardiac testing was helpful to identify a small subset of high-risk patients who might benefit from coronary revascularization. Sequential and selective antiadrenergic treatments were associated with improved postoperative cardiac outcome.
  
  
  CONCLUSIONS
  Implementation of American College of Cardiology/American Heart Association guidelines and use of antiadrenergic drugs were associated with better cardiac outcomes after major vascular surgery.
authors.affiliation: Division of Anesthesiology and Clinic of Cardiovascular Surgery, University Hospital, Geneva, Switzerland. licker-marc-joseph@hcuge.ch
authors.forename: Marc
authors.initials: M
authors.lastname: Licker
authors.forename: Gregory
authors.initials: G
authors.lastname: Khatchatourian
authors.forename: Alexandre
authors.initials: A
authors.lastname: Schweizer
authors.forename: Marek
authors.initials: M
authors.lastname: Bednarkiewicz
authors.forename: Didier
authors.initials: D
authors.lastname: Tassaux
authors.forename: Catherine
authors.initials: C
authors.lastname: Chevalley
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001012:Aorta, Abdominal / Q000601:surgery*; D003000:Clonidine / Q000627:therapeutic use; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000319:Adrenergic beta-Antagonists; D003000:Clonidine