Single cell expression analysis--pharmacogenomic potential.
A fundamental challenge in biology is to correlate physiology with gene expression in specific cell types. This can only be achieved by understanding gene expression at the level of the single cell because, in many systems, each cell has the capacity to express a unique set of genes. Therefore, each cell can be considered to be functionally distinct. A clearer understanding of gene expression differences at such a discrete level provides an opportunity to develop drugs with more targeted pharmacologies or with decreased side effects.
Dixon
A K
AK
Cambridge Biotechnology Ltd, Dept of Pharmacology, Tennis Court Road, UK.
Lee
K
K
Richardson
P J
PJ
Bell
M I
MI
Skynner
M J
MJ
D000818:Animals; D002468:Cell Physiological Phenomena / Q000187:drug effects*; D015870:Gene Expression / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*