Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.
We report the emergence of drug-resistant viral mutations in chronically HIV-infected individual undergoing structured treatment interruptions (STI). THe protease mutations K101E and K103N were detected at the end of the second or third STI. We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.
Schweighardt
Becky
B
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA.
Ortiz
Gabriel M
GM
Grant
Robert M
RM
Wellons
Melissa
M
Miralles
G Diego
GD
Kostrikis
Leondios G
LG
Bartlett
John A
JA
Nixon
Douglas F
DF
D019380:Anti-HIV Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D024882:Drug Resistance, Viral / Q000235:genetics*; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009154:Mutation; D012367:RNA, Viral / Q000235:genetics
D019380:Anti-HIV Agents; D012367:RNA, Viral