Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger.
Artemisinin (1) was transformed by Mucor polymorphosporus and Aspergillus niger. Five products were identified as 9beta-hydroxyartemisinin (2), 3beta-hydroxyartemisinin (3), deoxyartemisinin (4), 3beta-hydroxydeoxyartemisinin (5), and 1alpha-hydroxydeoxyartemisinin (6). Products 2, 3, and 6 are new compounds.
Zhan
Ji-Xun
JX
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China.
Zhang
Yuan-Xing
YX
Guo
Hong-Zhu
HZ
Han
Jian
J
Ning
Li-Li
LL
Guo
De-An
DA
D037621:Artemisinins / Q000378:metabolism*; D001234:Aspergillus niger / Q000378:metabolism*; D002384:Catalysis; D002681:China; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism*
D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin