title: N-(2-Mercaptoethyl)picolylamine as a diaminomonothiolate ligand for the "fac-[Re(CO)3]+" core.
abstract: N-(2-Mercaptoethyl)picolylamine (MEPAH) was studied as a potentially biologically relevant ligand for the "fac-[M(CO)(3)](+)" core (M = Re, (99)Tc, (99m)Tc). To this end, the complex Re(CO)(3)(MEPA) was synthesized. The reaction of MEPAH with fac-[Re(CO)(3)(MeCN)(3)](+) took place over the course of seconds, showing the high affinity possessed by this ligand for the "fac-[Re(CO)(3)](+)" core. A single-crystal X-ray diffraction study was performed confirming the nature of Re(CO)(3)(MEPA), a rare mononuclear rhenium(I) thiolate complex. Additional exploration into derivatization of the ligand backbone has afforded the analogous N-ethyl complex, Re(CO)(3)(MEPA-NEt). The high affinity of the ligand for the metal coupled with the ease of its derivatization implies that utilization of this ligand system for the purposes of (99m)Tc-radiopharmaceutical development is promising.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Kramer
authors.forename: Alan
authors.initials: A
authors.lastname: Davison
authors.forename: William M
authors.initials: WM
authors.lastname: Davis
authors.forename: Alun G
authors.initials: AG
authors.lastname: Jones
mesh_terms: D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray; D008024:Ligands; D008624:Mercaptoethylamines / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013457:Sulfur Compounds / Q000737:chemistry*
chemical_list: D008024:Ligands; D008624:Mercaptoethylamines; C472820:N-(2-mercaptoethyl)picolylamine; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013457:Sulfur Compounds