Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.
We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.
Leung
Suet Y
SY
Departments of Pathology and Surgery, University of Hong Kong, Hong Kong, China.
Chen
Xin
X
Chu
Kent M
KM
Yuen
Siu T
ST
Mathy
Jonathan
J
Ji
Jiafu
J
Chan
Annie S Y
AS
Li
Rui
R
Law
Simon
S
Troyanskaya
Olga G
OG
Tu
I-Ping
IP
Wong
John
J
So
Samuel
S
Botstein
David
D
Brown
Patrick O
PO
D000230:Adenocarcinoma / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D018076:DNA, Complementary / Q000235:genetics; D018450:Disease Progression; D004790:Enzyme Induction; D005753:Gastric Mucosa / Q000201:enzymology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D054501:Group II Phospholipases A2; D006801:Humans; D017403:In Situ Hybridization; D015993:Life Tables; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D010741:Phospholipases A / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D054467:Phospholipases A2; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D016019:Survival Analysis
D018076:DNA, Complementary; D009363:Neoplasm Proteins; D010741:Phospholipases A; D054501:Group II Phospholipases A2; C516287:PLA2G2A protein, human; D054467:Phospholipases A2; C516288:Pla2g2a protein, mouse