Molecular biology of the chromaffin cell.
A large number of molecular biology studies have been performed on chromaffin cells, and many genes involved in catecholamine synthesis, storage, and release have been cloned and their function determined. Catecholamine synthesis takes place in different cellular compartments, and enzymes involved in this process are subject to a fine regulation, as demonstrated by recent studies on their gene promoters. Genes coding for such intravesicular proteins as chromogranin A, B, and secretogranin II (chromogranin C) are also regulated in response to a variety of stimuli. Chromogranin gene promoters and transcription factors involved in their regulation have been elucidated. This review serves as an introduction to the studies described in the chapters to follow.
Trifaro
José-María
JM
Department of Cellular and Molecular Medicine, Faculty of Medicine,University of Ottawa, Ottawa, Ontario, Canada, K1H 8M1. jtrifaro@uottawa.ca
D000818:Animals; D002395:Catecholamines / Q000096:biosynthesis* / Q000235:genetics*; D019439:Chromaffin Cells / Q000378:metabolism* / Q000502:physiology*; D002864:Chromogranins / Q000235:genetics; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism; D011401:Promoter Regions, Genetic; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002395:Catecholamines; D002864:Chromogranins; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D010625:Phenylethanolamine N-Methyltransferase