title: Hepatic artery thrombosis and intraoperative hepatic artery flow rates in adult orthotopic liver transplantation.
abstract: BACKGROUND
  Thrombosis of the hepatic artery following orthotopic liver transplantation (OLT) can be a devastating com-plication impacting on recipient outcome. The utility of routine intraoperative flow measurements of the hepatic artery in predicting subsequent hepatic artery thrombosis (HAT) is presented in this study.
  
  
  METHODS
  Data on all adult OLT recipients between July 1995 and May 2000 were analysed. This included the routine intra-operative flow measurements of both the hepatic artery and portal vein using a Doppler flow meter.
  
  
  RESULTS
  Thirteen out of 198 (6.6%) instances of OLT were complicated by HAT. The mean and median flow rates of the hepatic artery in the OLT with HAT were 262 mL/min and 220 mL/min, respectively. These were significantly lower than the respective values of 436 mL/min and 400 mL/min in the OLT without HAT (P = 0.0036). This was independent of recipient age, sex, weight and intraoperative portal flow rates. However there was extensive overlap for the intraoperative hepatic artery flow rates obtained between the HAT and non-HAT groups. The risk of HAT was increased by a factor of 6 if the intraoperative hepatic artery flow rate was less than 200 mL/min. The average allograft survival was significantly lower in the HAT group at 373 days vs the non-HAT group at 763 days (P = 0.026).
  
  
  CONCLUSIONS
  The routine use of intraoperative flow measurements of the hepatic artery may be a useful adjunct in identifying the hepatic artery reconstruction, which is at risk of subsequent HAT.
authors.affiliation: Liver Transplant Unit, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Australia.
authors.forename: Martin
authors.initials: M
authors.lastname: Lin
authors.forename: Michael
authors.initials: M
authors.lastname: Crawford
authors.forename: Jodi
authors.initials: J
authors.lastname: Fisher
authors.forename: Kerry
authors.initials: K
authors.lastname: Hitos
authors.forename: Deborah
authors.initials: D
authors.lastname: Verran
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D006499:Hepatic Artery; D006801:Humans; D017078:Laser-Doppler Flowmetry; D016014:Linear Models; D016031:Liver Transplantation / Q000009:adverse effects*; D016343:Monitoring, Intraoperative; D009517:New South Wales / Q000453:epidemiology; D012189:Retrospective Studies; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*