Decreased expression of calretinin and calbindin in the labyrinth of old gerbils.
Calretinin and calbindin staining were compared in the vestibular periphery of old (35-48 months) and young (4-12 months) animals. Both stain calyx-only afferents; calbindin stains additional terminals in the apex [Brain Res. 928 (2002) 8-17]. In six of seven pairs of animals, calretinin and calbindin staining was diminished or absent in the old animals. These changes suggest that a reduction in certain calcium-binding proteins may be a characteristic of aging animals.
Kevetter
Golda Anne
GA
Department of Otolaryngology, University of Texas Medical Branch, Galveston, TX 77555-1063, USA. galeonar@utmb.edu
Leonard
Robert B
RB
D000375:Aging / Q000378:metabolism*; D000818:Animals; D064032:Calbindin 2; D064026:Calbindins; D015536:Down-Regulation / Q000502:physiology; D005849:Gerbillinae; D018069:Hair Cells, Vestibular / Q000166:cytology / Q000378:metabolism; D007150:Immunohistochemistry; D009410:Nerve Degeneration / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D009475:Neurons, Afferent / Q000166:cytology / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000166:cytology / Q000378:metabolism*; D014725:Vestibular Nerve / Q000166:cytology / Q000378:metabolism*; D014722:Vestibule, Labyrinth / Q000166:cytology / Q000378:metabolism*
D064032:Calbindin 2; D064026:Calbindins; D064030:S100 Calcium Binding Protein G