Coding of auditory temporal and pitch information by hippocampal individual cells and cell assemblies in the rat.
This study reports how hippocampal individual cells and cell assemblies cooperate for neural coding of pitch and temporal information in memory processes for auditory stimuli. Each rat performed two tasks, one requiring discrimination of auditory pitch (high or low) and the other requiring discrimination of their duration (long or short). Some CA1 and CA3 complex-spike neurons showed task-related differential activity between the high and low tones in only the pitch-discrimination task. However, without exception, neurons which showed task-related differential activity between the long and short tones in the duration-discrimination task were always task-related neurons in the pitch-discrimination task. These results suggest that temporal information (long or short), in contrast to pitch information (high or low), cannot be coded independently by specific neurons. The results also indicate that the two different behavioral tasks cannot be fully differentiated by the task-related single neurons alone and suggest a model of cell-assembly coding of the tasks. Cross-correlation analysis among activities of simultaneously recorded multiple neurons supported the suggested cell-assembly model.Considering those results, this study concludes that dual coding by hippocampal single neurons and cell assemblies is working in memory processing of pitch and temporal information of auditory stimuli. The single neurons encode both auditory pitches and their temporal lengths and the cell assemblies encode types of tasks (contexts or situations) in which the pitch and the temporal information are processed.
Sakurai
Y
Y
Department of Psychology, Graduate School of Letters, Kyoto University, Sakyo-ku, 606-8501, Kyoto, Japan. ysakurai@bun.kyoto-u.ac.jp
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009483:Neuropsychological Tests; D010898:Pitch Perception / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000502:physiology; D013998:Time Perception / Q000502:physiology*