title: Pediatric presentations of leptospirosis.
abstract: OBJECTIVE
  Leptospirosis in children is an often under diagnosed condition due to the non specificity of the presentations except for the classical Weil's disease.
  
  
  METHODS
  Children presenting with symptoms and signs suggestive of Leptospirosis were included in the study. Diagnostic criteria were fever, myalgia, conjunctival suffusion, Jaundice, headache, altered sensorium, seizures, bleeding manifestation and oliguria. Their clinical profile, lab parameters (general and specific), response to treatment and outcome were analysed.
  
  
  RESULTS
  One hundred and thirty nine cases were diagnosed during a 4-year period. The commonest symptoms were fever 133 (96%), headache and myalgia 34 (24%). Jaundice was present in only 25 (18%) of cases with renal failure in 2 cases. The frequently encountered clinical signs were hepatomegaly in 100 (72%), myalgia in 34 (24%) with icterus in 25 (18%), 12 (9%) of children presented with shock and 10 (7%) had meningitis. CPK estimated was a useful index of myositis. The diagnosis was confirmed by Dark field microscopy and paired or single high serological tests (MAT, ELISA IgM). Overlapping infections such as culture positive Salmonella typhi with leptospirosis (Serology positive) or Dengue Hemorrhagic fever with Leptospirosis presented with complications such as a myocarditis, shock and ARDS.
  
  
  CONCLUSIONS
  Presentation of non-icteric forms of Leptospirosis are often non-specific and may be missed unless there is a high index of suspicion. This study emphasizes the myositis and meningitis forms of leptospirosis. Delayed diagnosis leads to increased mortality and morbidity.
authors.affiliation: Kanchi Kamakoti Childs Trust Hospital, Nungambakkam, Chennai, India. saralarajaje@yahoocom
authors.forename: Sarala
authors.initials: S
authors.lastname: Rajajee
authors.forename: Janani
authors.initials: J
authors.lastname: Shankar
authors.forename: Lata
authors.initials: L
authors.lastname: Dhattatri
mesh_terms: D002648:Child; D005260:Female; D006529:Hepatomegaly; D006801:Humans; D007565:Jaundice / Q000382:microbiology; D007922:Leptospirosis / Q000175:diagnosis*; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000382:microbiology