How does histamine evoke catecholamine secretion from bovine chromaffin cells?
Histamine-evoked catecholamine secretion from bovine chromaffin cells was studied. Secretion was not prevented by inhibitors of IP3 receptors, protein kinase C, or phospholipase C; depleting Ca(2+) stores; or omitting extracellular Na(+) or Cl(-). Patch clamp studies showed histamine inhibited an M current, causing depolarization and firing of action potentials.
Marley
Philip D
PD
Department of Pharmacology, University of Melbourne, Victoria 3010, Australia. p.marley@unimelb.edu.au
Wallace
Damian
D
Donald
Amanda
A
McKenzie
Sacha
S
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D019439:Chromaffin Cells / Q000378:metabolism*; D005089:Exocytosis; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008564:Membrane Potentials; D009761:Nystatin / Q000378:metabolism; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors; D015398:Signal Transduction; D012964:Sodium / Q000378:metabolism; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors
D015220:Calcium Channels; D002395:Catecholamines; D053496:Inositol 1,4,5-Trisphosphate Receptors; D015221:Potassium Channels; D018160:Receptors, Cytoplasmic and Nuclear; D009761:Nystatin; D006632:Histamine; D012964:Sodium; D011493:Protein Kinase C; D010738:Type C Phospholipases; D002118:Calcium