title: Polyphenols from the heartwood of Cercidiphyllum japonicum and their effects on proliferation of mouse hair epithelial cells.
abstract: The methanol extract of heartwood of Cercidiphyllum japonicum (Cercidiphyllaceae) stimulated proliferation of mouse hair epithelial cells, similar to minoxidil and procyanidin B-2. (+)-Taxifolin ( 2), quercetin ( 3), myricetin ( 4), (+)-dihydromyricetin ( 5) and gallic acid ( 6) were isolated from C. japonicum and showed significant proliferative activities on the hair epithelial cells.
authors.affiliation: Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Towatari
authors.forename: Kiyo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Mori
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Kondo
authors.forename: Kokki
authors.initials: K
authors.lastname: Sakai
mesh_terms: D000818:Animals; D044946:Biflavonoids; D002392:Catechin / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects; D005419:Flavonoids; D006197:Hair / Q000166:cytology* / Q000187:drug effects*; D051379:Mice; D008914:Minoxidil / Q000494:pharmacology; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D044945:Proanthocyanidins; D031995:Saxifragaceae; D013936:Thymidine / Q000378:metabolism
chemical_list: D044946:Biflavonoids; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D044945:Proanthocyanidins; C479578:procyanidin B; C017674:procyanidin; D008914:Minoxidil; D002392:Catechin; D013936:Thymidine