title: Estrogens in female thyroid cancer: alteration of urinary profiles in pre- and post-operative cases.
abstract: To evaluate the potential effect of estrogens in premenopausal female thyroid cancer, the concentrations of 14 estrogens were quantitatively determined in the urine of pre- and post-operative patients with thyroid papillary cancer (18 patients case, 26 approximately 54 years) and normal female subjects (20 cases, 31 approximately 52 years). The highly sensitive gas chromatography-mass spectrometry-selected ion-monitoring method was used for estrogens analysis. And an estrogen-oxidative metabolism and 16alpha-hydroxyestrone to 2-hydroxyestrone (16alpha-OH E1/2-OH E1) which is the two primary and competing site of estrogen-oxidation, were determined. Catechol estrogens, including 2-OH E1, were also increased without significant changes of the other estrogen metabolites in pre-operative patients with thyroid papillary cancer compared with normal subjects. The lowest mean value of 16alpha-OH E1/2-OH E1 was remarked in pre-operative patients, and it was significantly different from the ratio of post-operative cases. As a result, it is suggested that the increase of 2-hydroxylation in estrogen metabolism may have a significant association with female thyroid cancer.
authors.affiliation: Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul, 130-650, South Korea.
authors.forename: Seon Hwa
authors.initials: SH
authors.lastname: Lee
authors.forename: Kyung Mee
authors.initials: KM
authors.lastname: Kim
authors.forename: Byung Hwa
authors.initials: BH
authors.lastname: Jung
authors.forename: Woung Youn
authors.initials: WY
authors.lastname: Chung
authors.forename: Cheong Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Bong Chul
authors.initials: BC
authors.lastname: Chung
mesh_terms: D000328:Adult; D004967:Estrogens / Q000652:urine*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000652:urine; D008875:Middle Aged; D011184:Postoperative Period; D013964:Thyroid Neoplasms / Q000601:surgery / Q000652:urine*
chemical_list: D004967:Estrogens; D006894:Hydroxyestrones; C026702:16-hydroxyestrone