title: [Outcome of allogeneic stem cell transplantation in patients older than 50 years of age].
abstract: Because of progress in supportive therapies, the upper limit of age for conventional allogenic stem cell transplantation (allo-SCT) is rising. We retrospectively evaluated the impact of age on transplant outcomes in patients older than 50 years of age who underwent conventional allo-SCT in 8 institutions in Japan. The median age was 52-years old (range 50 to 65). The underlying diseases included severe aplastic anemia (n = 3), acute myelogenous leukemia (n = 20), acute lymphoblastic leukemia (n = 10), chronic myelogenous leukemia (n = 11), myelodysplastic syndrome (n = 18), and non-Hodgkin lymphoma (n = 3). Forty two patients (67%) with hematological malignancies received allo-SCT in an advanced disease stage at the time of transplant. The two-year overall survival and disease-free survival rate were 50.1% and 43.6%, respectively. In patients with hematological malignancies, the two-year probability rates of survival were 54.3% with standard risk patients, and 45.9% with poor risk patients. The severity of acute GVHD, the kind of grafts, and age (> or = 55) were related to poor prognosis. Our data suggest that prophylaxis of acute GVHD and selection of the graft is more important for older patients, and that patients less than 55-years old can be candidates for conventional allo-SCT.
authors.affiliation: Department of Hematology, Saiseikai Maebashi Hospital.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takada
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
authors.forename: Atsuo
authors.initials: A
authors.lastname: Maruta
authors.forename: Heiwa
authors.initials: H
authors.lastname: Kanamori
authors.forename: Miki
authors.initials: M
authors.lastname: Nishimura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Aotsuka
authors.forename: Kenji
authors.initials: K
authors.lastname: Kishi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Miyawaki
mesh_terms: D000368:Aged; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000453:epidemiology; D006402:Hematologic Diseases / Q000401:mortality / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome