Genetics of ankylosing spondylitis.
Ankylosing spondylitis is a common inflammatory rheumatic disease. Both susceptibility to and clinical manifestations of the disease are highly heritable. Although some genes, notably HLA-B27, have been implicated in susceptibility to the disease, the genetics of the condition are complex and many more genes involved in the condition await discovery.
Brown
M A
MA
Wellcome Trust Centre for Human Genetics, Spondyloarthritis and Bone Disease Research Group, Oxford, United Kingdom. mbrown@well.ox.ac.uk
Wordsworth
B P
BP
Reveille
J D
JD
D002874:Chromosome Mapping; D015796:HLA-B27 Antigen / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000503:physiopathology
D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains