Inferences from whole-genome sequences of bacterial pathogens.
Genomic sequencing of bacterial pathogens has recently moved from the study of distantly related organisms to within-species comparisons of multiple strains. Strains often differ in their ability to cause disease, and comparative genomics is uncovering novel virulence determinants, hidden aspects of pathogenesis, and new targets for vaccine development. DNA microarrays and other gene-survey techniques are being used to quantify variability in gene content within bacterial populations, and to reveal the strain-specific basis for diversity and severity of pathology.
Whittam
Thomas S
TS
Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA. whittam@msu.edu
Bumbaugh
Alyssa C
AC
D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D005075:Biological Evolution; D019453:Escherichia coli O157 / Q000235:genetics; D016680:Genome, Bacterial; D016480:Helicobacter pylori / Q000235:genetics; D010802:Phylogeny; D012475:Salmonella / Q000235:genetics; D013297:Streptococcus pyogenes / Q000235:genetics; D015010:Yersinia pestis / Q000235:genetics