title: Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers.
abstract: We previously reported that CAB1 and c-ERBB-2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. During identification of this core region, CAB2, a human homologue of the yeast COS16 required for the repair of DNA double-strand breaks was cloned. Autofluorescence analysis of cells transfected with its GFP fusion protein demonstrated that CAB2 translocates into vesicles, suggesting that overexpression of CAB2 may decrease intercellular Mn2+ by accumulating it in the vesicles, in the same way as yeast COS16. This is the first report identifying all of the genes on the core amplified region of the 17q12 locus in breast and gastric cancers.
authors.affiliation: Genetics Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nezu
authors.forename: Michiko
authors.initials: M
authors.lastname: Nishigaki
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ishizuka
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kuwahara
authors.forename: Chikako
authors.initials: C
authors.lastname: Tanabe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sasaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Terada
mesh_terms: D000595:Amino Acid Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes; D013274:Stomach Neoplasms / Q000235:genetics*