title: [MRI findings and effectiveness of cyproheptadine in two patients with ophthalmoplegic migraine].
abstract: We reported the MRI findings and clinical course of two patients with ophthalmoplegic migraine. Both patients presented with unilateral oculomotor nerve palsy. Contrast enhanced MR imaging revealed unilateral enhancement and thickening of the oculomotor nerve in one patient. Prednisolone was effective in both patients, but only could transiently. On the other hand, cyproheptadine hydrochloride could completely prevent recurrent attacks of ophthalmoplegic migraine. Thus, MR imaging with of contrast enhancement is useful in the diagnosis of ophthalmoplegic migraine. Cyproheptadine hydrochloride is better than prednisolone to prevention recurrent attacks and to avoid adverse effects.
authors.affiliation: Division of Neurology, Saitama Children's Medical Center, Iwatsuki, Saitama.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Sugiyama
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Hamano
authors.forename: Manabu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Mika
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nara
mesh_terms: D002648:Child; D002675:Child, Preschool; D003533:Cyproheptadine / Q000627:therapeutic use*; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis* / Q000188:drug therapy*; D009886:Ophthalmoplegia / Q000150:complications*
chemical_list: D006634:Histamine H1 Antagonists; D003533:Cyproheptadine