title: Long-term prospective follow-up of endoscopic oesophagitis in southern Chinese--prevalence and spectrum of the disease.
abstract: OBJECTIVE
  To study the prevalence, clinical characteristics and long-term outcome of oesophagitis in Chinese patients.
  
  
  METHODS
  Clinical and endoscopic data were collected prospectively from consecutive patients who underwent upper endoscopy between 1997 and 2001. Patients with endoscopic oesophagitis were graded according to the Los Angeles system and analysed according to their clinical presentation, endoscopic details, Helicobacter pylori status, non-steroidal anti-inflammatory drug history, co-morbidity and mortality.
  
  
  RESULTS
  A total of 22,628 upper endoscopies were performed in 16,606 patients. Of these, 631 (3.8%) had endoscopic oesophagitis, 14 had benign oesophageal stricture (0.08%) and 10 had Barrett's oesophagus (0.06%). Most patients (94%) had either Los Angeles grade A or grade B oesophagitis. Patients who died during follow-up had a significantly higher incidence of co-morbid illness (100% vs. 63%, P < 0.001). By Cox regression analysis, the presence of gastrointestinal bleeding (P = 0.008), advanced age (P = 0.004) and the use of Ryle's tube (P = 0.043) were identified to be independent factors associated with mortality.
  
  
  CONCLUSIONS
  Complicated gastro-oesophageal reflux disease is uncommon in the Asian population. Advanced age, use of Ryle's tube and the presence of gastrointestinal bleeding are associated with a poor long-term outcome, which is a reflection of the severe underlying co-morbidity.
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China. wmwongg@hku.hk
authors.forename: W-M
authors.initials: WM
authors.lastname: Wong
authors.forename: S K
authors.initials: SK
authors.lastname: Lam
authors.forename: W M
authors.initials: WM
authors.lastname: Hui
authors.forename: K C
authors.initials: KC
authors.lastname: Lai
authors.forename: C K
authors.initials: CK
authors.lastname: Chan
authors.forename: W H C
authors.initials: WH
authors.lastname: Hu
authors.forename: H H X
authors.initials: HH
authors.lastname: Xia
authors.forename: C K
authors.initials: CK
authors.lastname: Hui
authors.forename: M F
authors.initials: MF
authors.lastname: Yuen
authors.forename: A O O
authors.initials: AO
authors.lastname: Chan
authors.forename: B C Y
authors.initials: BC
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000453:epidemiology; D002423:Cause of Death; D015897:Comorbidity; D004940:Esophageal Stenosis / Q000453:epidemiology; D004941:Esophagitis / Q000453:epidemiology* / Q000382:microbiology; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000302:isolation & purification; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index