title: How do microtubules guide migrating cells?
abstract: Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.
authors.forename: J Victor
authors.initials: JV
authors.lastname: Small
authors.forename: Benjamin
authors.initials: B
authors.lastname: Geiger
authors.forename: Irina
authors.initials: I
authors.lastname: Kaverina
authors.forename: Alexander
authors.initials: A
authors.lastname: Bershadsky
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D021961:Cell Membrane Structures / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*
chemical_list: D000199:Actins; D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins