title: Frequency of Helicobacter pylori infection in dyspeptic patients in Libya.
abstract: OBJECTIVE
  Helicobacter pylori infection is a very common infection worldwide particularly in the developing countries. The organism plays an important role in peptic ulcer diseases. The aim of the study was to detect and correlate the prevalence of Helicobacter pylori with such diseases and to evaluate the histopathological grading of gastritis.
  
  
  METHODS
  One hundred thirty two patients of 15-83 years of age (average 38) attending the endoscopy unit at the El-Jamahiria Hospital, Binghazi, Libya, mainly complaining from epigastric pain were randomly selected. Three antral biopsies for rapid urease test, direct smear stain and histology together with serum samples were obtained from each patient. Grading of gastritis and the presence of Helicobacter pylori was scored according to the Sydney system.
  
  
  RESULTS
  Patients were considered infected when 2 of the biopsy-based tests were positive. Helicobacter pylori was detected in 108 (82%) of 132 patients examined (86% by rapid urease test, 77% by direct smear stain, 95% by histology). The endoscopic findings revealed that 77 (77%) of 100 patients with non-ulcer dyspepsia, 26 (96%) of 27 with duodenal ulcer, 4 (100%) of 4 with gastric ulcer and in one patient with gastric cancer were Helicobacter pylori positive. The enzyme-linked immunosorbent assay test showed 94% sensitivity and 88% specificity. Histopathological sections from the majority of duodenal ulcer and gastric ulcer patients revealed higher grade (II and III) of gastritis than non-ulcer dyspepsia patients.
  
  
  CONCLUSIONS
  Helicobacter pylori infection is significantly correlated with peptic ulcer diseases than with non-ulcer dyspepsia. Patients with duodenal ulcer and gastric ulcer had a significantly higher grade of gastritis than patients with non-ulcer dyspepsia.
authors.affiliation: Department of Microbiology, Faculty of Medicine, Garyounis University, Benghazi, Libya.
authors.forename: Asim S
authors.initials: AS
authors.lastname: Bakka
authors.forename: Anis B
authors.initials: AB
authors.lastname: El-Gariani
authors.forename: Fouzi M
authors.initials: FM
authors.lastname: AbouGhrara
authors.forename: Barik A
authors.initials: BA
authors.lastname: Salih
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004415:Dyspepsia / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005756:Gastritis / Q000453:epidemiology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D008002:Libya; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence