NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of visceral leishmaniasis patients.
It is believed that the enhanced capability of activated macrophages to resist infection is related to the remarkable increase in the production of oxygen metabolites in response to phagocytosis. Both the production of H2O2 and the oxidation of NAD(P)H are directly dependent upon NAD(P)H-oxidase. It has been established that the respiratory burst is due to activation of NAD(P)H-oxidase localised in the plasmalemma. Myeloperoxidase is believed to be involved in augmenting the cytotoxic activity of H2O2. Low NADH-oxidase, NADPH-oxidase and myeloperoxidase activity were observed in monocytes of patients with active visceral leishmaniasis as compared with healthy controls. These results suggest that low NADH-oxidase, NADPH-oxidase and myeloperoxidase activities may account for persistence of Leishmania parasites in visceral leishmaniasis.
Kumar
Promod
P
Pai
Kalpana
K
Department of Biochemistry, Faculty of Science, Banaras Hindu University and *Department of Medicine, Institute of Medical Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi- 221005, India.
Pandey
Haushila P
HP
Sundar
Shyam
S
Department of Biochemistry, Faculty of Science, Banaras Hindu University and *Department of Medicine, Institute of Medical Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi- 221005, India.
D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D006801:Humans; D007893:Leishmania donovani / Q000276:immunology; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000201:enzymology* / Q000276:immunology / Q000469:parasitology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology / Q000469:parasitology; D009000:Monocytes / Q000201:enzymology; D009097:Multienzyme Complexes / Q000097:blood*; D009247:NADH, NADPH Oxidoreductases / Q000097:blood*; D019255:NADPH Oxidases / Q000097:blood*; D009195:Peroxidase / Q000097:blood*; D010587:Phagocytosis; D017382:Reactive Oxygen Species / Q000097:blood
D009097:Multienzyme Complexes; D017382:Reactive Oxygen Species; D009195:Peroxidase; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases