title: Catecholamine metabolism: an update on key biosynthetic enzymes and vesicular monoamine transporters.
abstract: At the meeting, new interesting information was presented on the complex regulation of catecholamine (CA) metabolism in different catecholaminergic neuroendocrine cells. In this review we focus on the rate-limiting enzymes in CA biosynthesis, including (1) structure-function relationships, (2) transcriptional and posttranslational regulation, and (3) disease-associated mutant forms. Moreover, some recent studies on the structure and function of the vesicular monoamine transporters are discussed.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bergen, N-5009 Bergen, Norway. torgeir.flatmark@pki.uib.no
authors.forename: Torgeir
authors.initials: T
authors.lastname: Flatmark
authors.forename: Bjørg
authors.initials: B
authors.lastname: Almas
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ziegler
mesh_terms: D000818:Animals; D001692:Biological Transport; D002395:Catecholamines / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D026901:Membrane Transport Proteins; D008954:Models, Biological; D009154:Mutation; D009479:Neuropeptides; D020411:Oligonucleotide Array Sequence Analysis; D011499:Protein Processing, Post-Translational; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D050492:Vesicular Biogenic Amine Transport Proteins
chemical_list: D002395:Catecholamines; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009479:Neuropeptides; D050492:Vesicular Biogenic Amine Transport Proteins; D014446:Tyrosine 3-Monooxygenase