title: Lactic acidosis in the rectal lumen of patients with septic shock measured by luminal equilibrium dialysis.
abstract: BACKGROUND
  Gut ischaemia may contribute to morbidity in sepsis, but little is known about the metabolic state of the gut mucosa in such patients.
  
  
  METHODS
  Nine patients with abdominal septic shock treated with norepinephrine, and ten healthy subjects, were subjected to equilibrium dialysis with a rectal balloon. pH, PCO(2) and concentrations of L-lactate were measured by auto-analyser.
  
  
  RESULTS
  In rectal dialysis fluid from patients with septic shock, acidosis was present (pH 7.23, 95% CI 7.11-7.36) and concentrations of L-lactate were approximately five times greater than controls (2.5-5.8 vs 0.5-1.2 mmol litre(-1)). The lactate concentration was related to the dose of norepinephrine (P<0.001). In contrast, values of dialysate PCO(2) did not differ significantly between patients and controls (6.4-11.0 vs 8.9-13.8 kPa).
  
  
  CONCLUSIONS
  The results suggest that, either lactic acidosis in rectal mucosa is related to shock severity, or that norepinephrine causes mucosal ischaemia. In any case, metabolic dysfunction is present in the rectal mucosa in patients with abdominal septic shock treated with norepinephrine.
authors.affiliation: Department of Anaesthesia and Intensive Care, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.
authors.forename: V
authors.initials: V
authors.lastname: Due
authors.forename: J
authors.initials: J
authors.lastname: Bonde
authors.forename: K
authors.initials: K
authors.lastname: Espersen
authors.forename: T H
authors.initials: TH
authors.lastname: Jensen
authors.forename: A
authors.initials: A
authors.lastname: Perner
mesh_terms: D000140:Acidosis, Lactic / Q000378:metabolism*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003956:Dialysis / Q000379:methods; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008875:Middle Aged; D012007:Rectum / Q000378:metabolism*; D012772:Shock, Septic / Q000378:metabolism*