[Multifocal progressive leukoencephalitis in a patient given fludarabine for chronic lymphoid leukemia].
A 74-year- man was hospitalized for subacute aphasia and right hemiparesis. He had had chronic lymphoid leukemia for 11 years and had been treated 5 months earlier with 3 courses of fludarabine. Magnetic resonance imaging showed lesions of the temporo-occipital white matter compatible with progressive multifocal leukoencephalitis (PML). The presence of JC virus was demonstrated first by in situ hybridation after a brain biopsy and second with polymerase chain reaction on CSF. The diagnosis of PML was confirmed. The causality of fludarabine treatment is discussed.
Léonard
S
S
Service de neurologie, Hôpital Central, CHU de Nancy, France.
Hulin
C
C
Anxionnat
R
R
Grignon
Y
Y
Taillandier
L
L
Vespignani
H
H
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001706:Biopsy; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D016133:Polymerase Chain Reaction; D014740:Vidarabine / Q000009:adverse effects* / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D014740:Vidarabine; C024352:fludarabine