High occurence of DRB1 11 in chronic lymphocytic leukaemia families.
Recently, linkage analysis of a series of familial chronic lymphocytic leukaemia (CLL) showed that affected sibling pairs did not share common major histocompatibilty complex haplotypes. We analysed Class I and II antigens in 11 Italian families with familial CLL. Although there was no association of disease status with any particular human leucocyte antigen, there was an overrepresentation of DRB1 11 alleles in these families (P = 0.009). A similar trend was also observed in a second series of nine French families (P = 0.002). Larger studies are needed to determine whether non-inherited paternal or maternal DRB1 antigens play a role in familial CLL development.
Theodorou
Ioannis
I
Laboratoire Central d' Immunologie Cellulaire Hôpital Pitié Salpêtrière, INSERM U550 Génétique Humaine des Maladies Infectieuses, Hôpital Necker-Enfants Malades, Paris, France. itheodor@infobiogen.fr
Abel
Laurent
L
Mauro
Francesca
F
Duprey
Brigitte
B
Magnac
Christian
C
Payelle-Brogard
Béatrice
B
Davi
Frederic
F
Dighiero
Guillaume
G
D005805:Genes, MHC Class I / Q000235:genetics; D005802:Genes, MHC Class II / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D010375:Pedigree; D011446:Prospective Studies
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains