[Investigation of the teratogenic and embryotoxic action of xenon].
30 Wistar rats inhaled a Xe (80%):O2(20%) mixture for 2 hours twice a week on the 1st to 19th days of pregnancy. On the 20th day of pregnancy 70% rats were exposed to euthanasia, the rest of animals were left for labors to study the postnatal course in the progeny. Inhaling the Xe (80%):O2(20%) mixture did not affect either the changes in body mass of pregnant rats, indices of postimplantating loss of embryos and pregnancy duration or the number of live newborns, their body mass and sizes. Xenon caused neither inhibition of osteal system development nor any malformations. The results of study permit one to look optimistically at the prospects for using Xenon in obstetrical anesthesiology.
Burov
N E
NE
Arzamastsev
E V
EV
Kornienko
L Iu
LIu
Kudimova
L A
LA
D018685:Anesthetics, Inhalation / Q000633:toxicity*; D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D008098:Litter Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects; D014978:Xenon / Q000633:toxicity*
D018685:Anesthetics, Inhalation; D014978:Xenon