External chiral ligand-mediated enantioselective Peterson reaction of alpha-trimethylsilanylacetate with substituted cyclohexanones.
[reaction: see text] The asymmetric Peterson reaction of an alpha-trimethylsilanylacetate with 4-substituted and 3,5-disubstituted cyclohexanones was mediated by an external chiral tridentate ligand to give the corresponding olefins with an axial chirality in high yields and enantioselectivities of up to 85%.
Iguchi
Mayu
M
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Tomioka
Kiyoshi
K