[The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury].
OBJECTIVE
To investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury.


METHODS
Rats inflicted with smoke inhalation injury were employed as the model. WBC in BALF (bronchoalveolar lavage fluid), MPO (myeloperoxidase) activity, hydrogen peroxide (H(2)O(2)) content, GSH (glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined.


RESULTS
Postinjury WBC in BALF, MPO activity in pulmonary tissue and H(2)O(2) content decreased obviously after NAC treatment. But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC.


CONCLUSIONS
NAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury. AS a result, the pulmonary antioxidant capacity was improved.
Fu
Zuhong
Z
Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P.R. China.
Yang
Zongcheng
Z
Liu
Li
L
Liu
Zhiyuan
Z
He
Baobin
B
Liu
Zhixia
Z
Wu
Jiangping
J
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015208:Smoke Inhalation Injury / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D016166:Free Radical Scavengers; D006861:Hydrogen Peroxide; D009195:Peroxidase; D005978:Glutathione; D000111:Acetylcysteine