Fast-breaking results on the PACAP/VIP/secretin peptide family in chromaffin cells.
The neuropeptide pituitary adenylyl cyclase-activating polypeptide (PACAP) has been reported to be a potent regulator of chromaffin cell activity. In particular, PACAP stimulates catecholamine biosynthesis as well as the expression of various genes, including chromogranin A, neuropeptide Y, enkephalins, vasoactive intestinal polypeptide, and PACAP itself. The mechanisms involved in the effects of PACAP on chromaffin cells have been investigated using rat pheochromocytoma PC12 cells. This cell line turned out to be a suitable model in which to study the neurotrophic activities of PACAP. Recent studies using transgenic mice have shown that in the sympathoadrenal system, PACAP acts as an "emergency response" cotransmitter involved in the regulation of insulin-induced hypoglycemia.
Vaudry
David
D
Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA. vaudry@codon.nih.gov
Taupenot
Laurent
L
D000818:Animals; D001665:Binding Sites; D002454:Cell Differentiation; D019439:Chromaffin Cells / Q000378:metabolism*; D019143:Evolution, Molecular; D007700:Kinetics; D051379:Mice; D008822:Mice, Transgenic; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D016716:PC12 Cells; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D012633:Secretin / Q000235:genetics / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000737:chemistry / Q000378:metabolism*
C495402:Adcyap1 protein, mouse; C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012633:Secretin; D014660:Vasoactive Intestinal Peptide