title: Automation of [11C]acyl chloride syntheses using commercially available 11C-modules.
abstract: In implementing published procedures for the incorporation of [11C]carbon dioxide on the immobilized Grignard reagents for the radiosynthesis of [11C]acyl chlorides, several modifications on a commercial PET tracer synthesizer module for 11C-methylations were made to obtain reliable and reproducible production processes for routine clinical applications. High yields of [carbonyl-11C]WAY-100635 and [11C]zofenoprilat were obtained via 11C-carboxylation using [carbonyl-11C]cyclohexanecarbonyl chloride and 2-methyl-[l-11C]acryloyl chloride prepared with the modified module.
authors.affiliation: INB-CNR, University of Milano-Bicocca, Institute H.S. Raffaele, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Matarrese
authors.forename: Francesco
authors.initials: F
authors.lastname: Sudati
authors.forename: Dmitri
authors.initials: D
authors.lastname: Soloviev
authors.forename: Sergio
authors.initials: S
authors.lastname: Todde
authors.forename: Elia Anna
authors.initials: EA
authors.lastname: Turolla
authors.forename: Marzia Galli
authors.initials: MG
authors.lastname: Kienle
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Fazio