title: Late health effects of childhood nasopharyngeal radium irradiation: nonmelanoma skin cancers, benign tumors, and hormonal disorders.
abstract: Nasopharyngeal radium irradiation (NRI) was widely used from 1940 through 1970 to treat otitis serosa in children and barotrauma in airmen and submariners. We assessed whether NRI-exposed individuals were at higher risk for benign tumors, nonmelanoma skin cancer, thyroid disorders, and conditions related to regulatory control of anterior pituitary hormones, such as growth and reproductive characteristics. We conducted a retrospective cohort study in 3,440 NRI-exposed and 3,088 nonexposed subjects, who as children were treated at nine ear, nose and throat clinics in The Netherlands between 1945 and 1981. Based on information from original medical records, we traced vital status through follow-up at municipal population registries. Disease status (including medical confirmation) and indicators of pituitary gland radiation damage were assessed from a self-administered questionnaire in 1997. The average radiation doses were 11, 7, and 1.5 cGy for pituitary, parotid, and thyroid gland, respectively, and 3.2 cGy for the facial skin. Among exposed subjects, 23 benign head and neck tumors were observed, compared with 21 among nonexposed subjects. Elevated risk of basal cell carcinoma of the head and neck area was observed in exposed subjects (odds ratio = 2.6; 95% confidence interval: 1.0-6.7). Exposed and nonexposed groups did not differ substantially with regard to thyroid disorders, height, and reproductive characteristics, although exposed males more frequently reported a history of fertility problems compared with nonexposed males (odds ratio = 1.4; 95% confidence interval: 1.0-2.1). We found no evidence of highly elevated risk of benign head and neck tumors, nonmelanoma skin cancer, thyroid disorders, or indicators of pituitary radiation damage after childhood NRI in The Netherlands.
authors.affiliation: Department of Ear, Nose and Throat Medicine, Reinaert Kliniek, Maastricht, The Netherlands. ronckerc@mail.nih.gov
authors.forename: Cécile M
authors.initials: CM
authors.lastname: Ronckers
authors.forename: Charles E
authors.initials: CE
authors.lastname: Land
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hayes
authors.forename: Pieter G
authors.initials: PG
authors.lastname: Verduijn
authors.forename: Marilyn
authors.initials: M
authors.lastname: Stovall
authors.forename: Flora E
authors.initials: FE
authors.lastname: van Leeuwen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001827:Body Height / Q000528:radiation effects; D002280:Basal Cell Carcinoma / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004700:Endocrine System Diseases / Q000209:etiology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000528:radiation effects*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009426:Netherlands; D010902:Pituitary Gland / Q000528:radiation effects; D011883:Radium / Q000008:administration & dosage / Q000009:adverse effects*; D012098:Reproduction / Q000528:radiation effects; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology*; D013959:Thyroid Diseases / Q000209:etiology
chemical_list: D011883:Radium