title: Role for HPV testing in ASCUS: a cytologic-histologic correlation.
abstract: Human papilloma virus (HPV) Hybrid Capture II testing was introduced at our institution in mid-April, 2001. Relatively little data exists on the histologic follow-up of "high-risk HPV-positive ASCUS" patients without a previous abnormal Pap result. The results of the cytologic-histologic correlation of 50 patients over an 11-mo period are presented. Our results indicate that significant lesions may be discovered in patients of the "high-risk HPV-positive ASCUS" category who have no previous abnormal Pap history. Of the 50 patients presented in this study, histologic follow-up demonstrated evidence of squamous carcinoma in one patient (2%), high-grade squamous intraepithelial lesion (HSIL) in eight patients (16%), and low-grade squamous intraepithelial lesion (LSIL) in 19 patients (38%). The other 22 (44%) showed chronic cervicitis, reactive changes, or no pathologic changes. These findings suggest a more aggressive clinical approach may be warranted in the management of new onset ASCUS positive for high risk HPV.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. DCrab15466@aol.com
authors.forename: Dwayne
authors.initials: D
authors.lastname: Crabtree
authors.forename: April
authors.initials: A
authors.lastname: Unkraut
authors.forename: Donna
authors.initials: D
authors.lastname: Cozens
authors.forename: Tina
authors.initials: T
authors.lastname: Smith
authors.forename: Cinda
authors.initials: C
authors.lastname: Lucas
authors.forename: Donna
authors.initials: D
authors.lastname: Pennington
authors.forename: Lois
authors.initials: L
authors.lastname: Chaney
authors.forename: Blake
authors.initials: B
authors.lastname: Nestok
authors.forename: Toni
authors.initials: T
authors.lastname: Robinson-Smith
authors.forename: Rawia
authors.initials: R
authors.lastname: Yassin
mesh_terms: D000293:Adolescent; D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology*; D016037:Single-Blind Method; D014412:Tumor Virus Infections / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*; D014626:Vaginal Smears / Q000379:methods
chemical_list: D004279:DNA, Viral