Growth signaling: TSC takes its place.
The protein products of the tumor suppressor genes tuberous sclerosis complex 1 and 2 form a protein complex, TSC1-TSC2, that inhibits growth. Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition.
Marygold
Steven J
SJ
Growth Regulation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK.
Leevers
Sally J
SJ
D000818:Animals; D002455:Cell Division / Q000235:genetics; D048429:Cell Size; D016147:Genes, Tumor Suppressor; D006128:Growth / Q000235:genetics*; D006801:Humans; D011506:Proteins / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics; D015398:Signal Transduction; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
D011506:Proteins; D012097:Repressor Proteins; C000624650:TSC1 protein, human; C000624653:TSC2 protein, human; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins