title: Toxoplasmosis, an overview with emphasis on ocular involvement.
abstract: Toxoplasmosis is a common parasitic zoonosis and an important cause of abortions, mental retardation, encephalitis, blindness, and death worldwide. Although a large body of literature has emerged on the subject in the past decades, many questions about the pathogenesis and treatment of the disease remain unanswered. This review aims to provide an overview of the current insights regarding the causative parasite and the mechanisms leading to symptomatic infection with emphasis on ocular toxoplasmosis.
authors.affiliation: Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands. v.klaren@ioi.knaw.nl
authors.forename: Vincent N A
authors.initials: VN
authors.lastname: Klaren
authors.forename: Aize
authors.initials: A
authors.lastname: Kijlstra
mesh_terms: D000208:Acute Disease; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000917:Antibody Formation; D002908:Chronic Disease; D005128:Eye Diseases / Q000469:parasitology; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D014122:Toxoplasma / Q000502:physiology*; D014123:Toxoplasmosis / Q000175:diagnosis / Q000235:genetics / Q000469:parasitology* / Q000628:therapy; D014125:Toxoplasmosis, Congenital / Q000469:parasitology; D014126:Toxoplasmosis, Ocular / Q000469:parasitology
chemical_list: D000913:Antibodies, Protozoan