Identification of a new HLA-DRB1 allele, DRB1*0321.
This communication reports the identification of a new HLA-DRB1*03 allele identified in three members of a Caucasian French family. This new allele has been officially named HLA-DRB1*0321 by the World Health Organization Nomenclature Committee. The complete exon 2 sequence of DRB1*0321 is identical to that of DRB1*0307 except for the first and second nucleotides of codon 37 (TT replacing AA), which lead to the substitution of a tyrosine for a phenylalanine (AAC-->TTC at position 37). The family study showed that this new allele was transmitted into the HLA-A*0101/09, -B*0801/14, -Cw*0701, -DRB1*0321, -DRB3*0101, -DQB1*0503 and -DPB1*0401 haplotype. The complete exon 2 sequence of this new allele has been previously deposited in the EMBL Sequence Database under accession number AF297266.
Gagne
K
K
Laboratoire d'Immunogénétique et d'Histocompatibilité, EFS Pays de Loire, Nantes cedex, France.
Bonneville
F
F
Cheneau
M-L
ML
Herry
P
P
Pinson
M-J
MJ
Herfray
P
P
Cesbron-Gautier
A
A
Folléa
G
G
Bignon
J-D
JD
D000483:Alleles; D001483:Base Sequence; D016026:Bone Marrow Transplantation / Q000276:immunology; D005091:Exons / Q000235:genetics; D005192:Family Health; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains