title: [Analysis of the efficacy of lung-protective ventilation strategy in burn patients with respiratory dysfunction].
abstract: OBJECTIVE
  To investigate the efficacy of lung-protective ventilation strategy in burn patients with respiratory dysfunction.
  
  
  METHODS
  Mechanical ventilation was employed in 11 cases of severely burned patients with the pattern of synchronized intermittent mandatory ventilation and pressure support ventilation (SIMV + PSV). The tidal volume was set at 6 approximately 8 ml/kg and inspiratory plateau pressure was equal to or less than (</=) 30 cmH(2)O. PEEP was set at 8 approximately 10 cmH(2)O and FiO(2) 40% approximately 50%. Blood gas analysis indices were dynamically monitored and clinical outcome was observed.
  
  
  RESULTS
  SIMV and PSV were applied in these patients for an average of 12.77 +/- 8.06 days. After treatment, the PaO(2)/FiO(2) ratio was obviously increased from 193.54 +/- 53.3 to 327.14 +/- 106.53 (P < 0.01). Furthermore, the PaCO(2) and pH values remained at normal range. Five out of 11 patients finally died, in which 3 were due to renal failure and one due to multiple organ dysfunction (MOD).
  
  
  CONCLUSIONS
  Respiratory support in severely burned patients could be achieved by lung-protective ventilation strategy.
authors.affiliation: Burn Institute of Tian Jin 300222, P.R. China.
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.forename: Gengxiang
authors.initials: G
authors.lastname: Liu
authors.forename: Shilin
authors.initials: S
authors.lastname: Deng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation / Q000502:physiology*; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000209:etiology*