title: Hyperostotic bone disease in red pandas (Ailurus fulgens).
abstract: Three adult red pandas (Ailurus fulgens) developed multiple periarticular exostoses in their elbow joints. Two of these animals also had extensive periosteal new bone formation and osteosclerosis of the ulnae and radii and mild periosteal new bone deposition on the femurs. One animal also showed extensive hyperostosis of the cranium and mandibles. Dietary concentrations of calcium and phosphorus were estimated to be adequate, but dietary vitamin A and D appeared excessive when compared with recommended levels for this species. Serum vitamin A concentrations were not elevated in the two most severely affected animals, but their liver vitamin A content was higher than what is considered normal for most domestic animal species. Serum 25-hydroxy vitamin D concentrations were within normal ranges for domestic species. A definitive diagnosis for the cause of the lesions was not established, but hypervitaminosis A was suspected.
authors.forename: Michael
authors.initials: M
authors.lastname: Lynch
authors.forename: Helen
authors.initials: H
authors.lastname: McCracken
authors.forename: Ronald
authors.initials: R
authors.lastname: Slocombe
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D002335:Carnivora; D004032:Diet / Q000009:adverse effects / Q000662:veterinary; D005260:Female; D015576:Hyperostosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D006986:Hypervitaminosis A / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008099:Liver / Q000737:chemistry; D008297:Male; D014801:Vitamin A / Q000008:administration & dosage / Q000032:analysis; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014801:Vitamin A; D014807:Vitamin D; C104450:25-hydroxyvitamin D