title: The FEAR Before MEN: networks of mitotic exit.
abstract: Variations in the normal regulation of the mitotic cell cycle can lead to such global cellular changes as differential development or malignant transformation. Studies on the control of mitosis are particularly important to discover the details of the basic mechanisms responsible for normal cell division, as well as to learn about strategies employed by cancerous cells to indefinitely proliferate. The past years have brought noteworthy progress in elucidating the molecular pathways that regulate crucial events during mitosis such as: chromosome condensation, formation of the mitotic spindle, chromosome segregation, cytokinesis, and disassembly of the mitotic spindle.
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. dtp3@pitt.edu
authors.forename: Teodora Pene
authors.initials: TP
authors.lastname: Dumitrescu
authors.forename: William S
authors.initials: WS
authors.lastname: Saunders
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division; D016213:Cyclins / Q000378:metabolism; D010450:Endopeptidases; D018816:Genes, cdc / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D064247:Separase
chemical_list: D018797:Cell Cycle Proteins; D016213:Cyclins; D008869:Microtubule-Associated Proteins; D029701:Saccharomyces cerevisiae Proteins; C437104:Slk19 protein, S cerevisiae; D011494:Protein Kinases; C085768:DBF2 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases; D010450:Endopeptidases; D064247:Separase