Two new and four known polyphenolics obtained as new cell-cycle inhibitors from Rubus aleaefolius Poir.
Two new polyphenolics, rubuphenol (1) and sanguiin H-2 ethyl ester (2), were isolated together with ellagic acid (3), ethyl gallate (4), 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose (5) and 1,2,3,6-tetra-O-galloyl-beta-D-glucopyranose (6) as new cell-cycle inhibitors from Rubus aleaefolius by bioassay-guided separation procedure and the structures of 1 and 2 were elucidated by spectroscopic method. Compounds 1-6 inhibited the cell cycle progression of tsFT210 cells at the G0/G1 phase with the MIC values of 14.6 microM (1), 22.1 microM (2), 10.3 microM (3), 7.8 microM (4), 7.9 microM (5) and 6.6 microM (6).
Cui
Cheng-Bin
CB
Beijing Institute of Biomedicine, Xinjian Gongmen Road No. 15, Haidian District, Beijing 100091, People's Republic of China. cuicb@sohu.com
Zhao
Qing-Chun
QC
Cai
Bing
B
Yao
Xin-Sheng
XS
Osadsa
Hiroyuki
H
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D005419:Flavonoids; D005434:Flow Cytometry; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D027824:Rosaceae / Q000737:chemistry*
D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D059808:Polyphenols