title: [Antisynthetase syndrome].
abstract: BACKGROUND
  Traditionally, idiopathic inflammatory myopathies have been classified into three groups; polymyositis, dermatomyositis and inclusion body myositis. Recent developments in immunology have improved our knowledge and it is now possible to classify these disorders according to the presence of myositis specific autoantibodies.
  
  
  METHODS
  Four adult patients with anti-Jo-1 antibodies, one male and three females are presented.
  
  
  RESULTS
  All patients had myositis, but interstitial lung disease represented the main clinical manifestation. One patient had polyarthritis and mechanic hands. Two patients had Gottron's sign, one had Gottron's papules and one female patients had subcutaneous calcinosis. Raynaud's phenomenon was present in two patients.
  
  
  CONCLUSIONS
  Patients presenting with interstitial lung disease should be carefully evaluated for the antisynthetase syndrome.
authors.affiliation: Revmatologisk avdeling Rikshospitalet 0027 Oslo. jan.tore.gran@rikshospitalet.no
authors.forename: Jan Tore
authors.initials: JT
authors.lastname: Gran
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001168:Arthritis / Q000175:diagnosis* / Q000276:immunology; D003882:Dermatomyositis / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis* / Q000276:immunology; D011928:Raynaud Disease / Q000175:diagnosis* / Q000276:immunology; D013577:Syndrome
chemical_list: D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody