title: Transcatheter closure of patent ductus arteriosus in adults using the Amplatzer duct occluder: initial results and follow-up.
abstract: BACKGROUND
  Surgical closure of patent ductus arteriosus in adult patients may be problematic. Transcatheter closure of patent ductus arteriosus is an established procedure. Recently, transcatheter closure of patent ductus arteriosus using the Amplatzer duct occluder has been shown to be safe and efficacious. We present our experience with this device in adults.
  
  
  RESULTS
  Between January 2000 and January 2002,41 adult patients (31 females and 10 males) with a patent ductus arteriosus were referred for closure with the Amplatzer duct occluder. The median age was 35.6 years (range 18-70.7 years) and the median weight was 65.8 kg (range 32.7-164.5 kg). Of these 41 patients, 37 underwent attempted closure of the patent ductus arteriosus using the Amplatzer duct occluder. The device was successfully deployed in all patients except 1. Complete angiographic closure was seen Immediately after device deployment in 29 out of 36 patients (81%). Complete echocardiographic closure was demonstrated within 24 hours post-procedure in 34 out of 36 patients (94%), and at 6-month follow-up in 35 out of 36 patients (97%). No complications related to device implantation occurred in any patient.
  
  
  CONCLUSIONS
  Closure of patent ductus arteriosus using the Amplatzer duct occluder is safe and effective in adults.
authors.affiliation: Section of Pediatric Cardiology, The University of Chicago Children's Hospital, IL 60637, USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Hong
authors.forename: William E
authors.initials: WE
authors.lastname: Hellenbrand
authors.forename: Ziyad M
authors.initials: ZM
authors.lastname: Hijazi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000497:Alloys; D021721:Balloon Occlusion / Q000295:instrumentation*; D006328:Cardiac Catheterization / Q000295:instrumentation; D004374:Ductus Arteriosus, Patent / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D016896:Treatment Outcome
chemical_list: D000497:Alloys; C013616:nitinol