Role of Fig2p in agglutination in Saccharomyces cerevisiae.
In W303-derived strains, disruption of FIG2 increased agglutinability of alpha cells, but not a cells, and did not alter expression of alpha-agglutinin, binding of 125I-labeled alpha-agglutinin, or mating efficiency. Fig2p overexpression led to alpha-cell-specfic suppression of agglutinability. These results imply that Fig2p is an indirect masker of the active sites in alpha-agglutinin.
Jue
Chong K
CK
Department of Biological Sciences and the Center for Gene Structure and Function, Hunter College, City University of New York, New York 10021, USA.
Lipke
Peter N
PN
D002448:Cell Adhesion / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D000072235:Mating Factor; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D010675:Pheromones / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
D010455:Peptides; D010675:Pheromones; D029701:Saccharomyces cerevisiae Proteins; D000072235:Mating Factor