title: Myofibroblastoma in the suprasellar region. Case report.
abstract: Myofibroblastoma is a rare type of benign mesenchymal tumor; only two cases of intracranial myofibroblastoma have been reported in the literature. The authors report on the case of a 34-year-old woman with a myofibroblastoma in the suprasellar region who presented with the complaint of sudden onset of headache followed within 2 weeks by progressively worsening visual disturbance. Computerized tomography scanning demonstrated a mixed low- and high-density mass in the suprasellar region and contrast-enhanced magnetic resonance imaging revealed the mass to be of mixed intensity with heterogeneous enhancement. The tumor was subtotally removed via a right frontobasal translamina-terminalis approach and her vision improved immediately. Histologically, the tumor was characterized by alternating areas of spindle-shaped and round cells that were separated by collagen fibers. The diagnosis of myofibroblastoma was based on the tumor's intense immunoreactivity for alpha-smooth-muscle actin and the ultrastructural identification of myofibroblasts. The tumor was thought to have originated from the meninges in the suprasellar region.
authors.affiliation: Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan. 008m9020@med.stud.kumamoto-u.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Shinojima
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohta
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yano
authors.forename: Hideo
authors.initials: H
authors.lastname: Nakamura
authors.forename: Masato
authors.initials: M
authors.lastname: Kochi
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Ishimaru
authors.forename: Youichi
authors.initials: Y
authors.lastname: Nakazato
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ushio
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012658:Sella Turcica; D014057:Tomography, X-Ray Computed