title: Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes.
abstract: Five fatty acid derivatives including three novel compounds were isolated from the mushroom Clitocybe clavipe. Their structures were elucidated by spectral analyses. These compounds inhibited aldehyde dehydrogenase in vitro.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422-8529, Japan. achkawa@agr.shizuoka.ac.jp
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kawagishi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kume
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Arimoto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Inakuma
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D001487:Basidiomycota / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D007564:Japan; D008049:Lipase / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D005227:Fatty Acids; D000444:Aldehyde Dehydrogenase; D008049:Lipase