Bioavailability of ranitidine in healthy Mexican volunteers: effect of food.
Is well known that food can affect the bioavailability of several drugs, its impact is major for those drugs that have to act near of drug absorption. Documentation about alterations of ranitidine bioavailability by effect of food is poor. The purpose of this work was to evaluate the effect of food over the bioavailability of ranitidine. Twenty healthy Mexican volunteers were included for the study. The study was made in two stages, in the first one the volunteers had 12 hour fast and took a 300 mg of oral dose of ranitidine (without food, WOF) and blood samples were drawn. Two weeks later, the volunteers took a normal diet just before ranitidine intake (with food, WF). The area under the curve (AUC) was 30% greater in WOF, Cmax was 921.5 ng/ml (WF) vs. 1685.2 (WOF), and t1/2 was 2.70 +/- 1.38 (WF) h vs 3.66 +/- 1.34 (WOF). The AUC, Cmax and t1/2 were statistically different. It is evident that there are differences in the drug disposition due to the presence of food, then, it is possible that the efficacy of ranitidine as inhibitor of gastric secretion being limited by food.
Juárez-Olguín
H
H
Department of Pharmacology, National Institute of Pediatrics, Avenue Imán No. 13th Piso, Colony Cuicuilco, CP 04530 Mexico City, Mexico. juarezol@yahoo.com
Flores
J
J
Pérez
G
G
Hernández
G
G
Flores
C
C
Guillé
A
A
Camacho
A
A
Toledo
A
A
Carrasco
M
M
Lares
I
I
D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D018565:Food-Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011899:Ranitidine / Q000097:blood / Q000493:pharmacokinetics*
D000897:Anti-Ulcer Agents; D011899:Ranitidine