Expression of chemokine receptor CXCR3 on cerebrospinal fluid T-cells is related to active MRI lesion appearance in patients with relapsing-remitting multiple sclerosis.
We evaluated CXCR3 expression on T-cells and levels of its ligand CXCL10 in blood and cerebrospinal fluid (CSF) of 22 patients with relapsing-remitting multiple sclerosis (RR-MS) in association with magnetic resonance imaging (MRI) disease activity. CXCL10 was strongly released intrathecally, but did not change in association with MRI activity. CXCR3 expression on T-cells was lower in the peripheral blood (PB) of RR-MS patients compared to healthy controls and was increased in the CSF of RR-MS patients undergoing acute attacks, as illustrated by Gd-enhancing lesions on MRI, compared to patients without enhancing lesion. Our results suggest that MRI-documented disease activity is associated with an increase of CXCR3 positive T-cells in the CSF, possibly due to the migration of activated T-cells from the circulation into the CSF.
Sindern
Eckhart
E
Department of Neurology, Ruhr University, BG-Kliniken Bergmannsheil, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Germany. eckhart.sindern@ruhr-uni-bochum.de
Patzold
Tanja
T
Ossege
Ludgera Manuela
LM
Gisevius
Astrid
A
Malin
Jean Pierre
JP
D000328:Adult; D017252:CD3 Complex / Q000032:analysis; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D017252:CD3 Complex; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine