[High-dose chemotherapy with autologous bone marrow transplantation in children with high-risk malignant neoformations].
The role of high-dose chemotherapy; with subsequent autologous bone marrow rescue (AutoBMR) for high risk or recurrence of advanced solid tumor was evaluated in 16 children (August 1998-March 2001). At present, 11 (69%) patients are still alive, showing no evidence of the disease, 11-31 mo after therapy (median follow-up of 17 mo). Tumor progression was reported in 5 (31%) at months 5, 6, 8, 9 and 11 (after AutoBMR rhabdosarcoma--3; Ewing's sarcoma--2). Overall and recurrence-free survival among all patients was 74 and 66%, respectively.
Aleĭnikova
O V
OV
Republican Center for Pediatric Oncology and Hematology Research, Minsk, Belarus.
Strongin
Iu S
IuS
Pochetukhin
K V
KV
D000293:Adolescent; D000367:Age Factors; D000970:Antineoplastic Agents / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D016190:Carboplatin / Q000008:administration & dosage; D002330:Carmustine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000627:therapeutic use; D003606:Dacarbazine / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D011034:Podophyllotoxin / Q000627:therapeutic use; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D012737:Sex Factors; D018709:Statistics, Nonparametric; D013997:Time Factors; D014182:Transplantation, Autologous; D014747:Vinblastine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D003561:Cytarabine; D001761:Bleomycin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D016190:Carboplatin; D011034:Podophyllotoxin; D008558:Melphalan; D002330:Carmustine