Reactivation of a Trypanosoma cruzi infection in a rhesus monkey (Macaca mulatta) experimentally infected with SIV.
Trypanosoma cruzi-like flagellates were incidentally noted in blood smears of a routinely monitored rhesus monkey experimentally infected with the simian immunodeficiency virus (SIV). Immunodeficiency in the course of the SIV infection reactivated a chronic infection of Chagas' disease that had been unnoticed when the macaque was imported to Europe. The animal developed no specific clinical symptoms of American trypanosomiasis, but histologically a chagasic myocarditis was detected. Analysis of the small subunit rRNA gene of the trypanosome identified the protozoan as T. cruzi.
Kunz
E
E
Department of Primate Veterinary Medicine and Primate Husbandry, German Primate Center, 37077 Göttingen, Germany. emanuela.kunz@ze.uni-ulm.de
Mätz-Rensing
K
K
Stolte
N
N
Hamilton
P B
PB
Kaup
F J
FJ
D000818:Animals; D002598:Chagas Cardiomyopathy / Q000473:pathology / Q000662:veterinary / Q000821:virology; D014355:Chagas Disease / Q000150:complications / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000469:parasitology* / Q000473:pathology / Q000821:virology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000469:parasitology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000254:growth & development*; D014349:Trypanosoma cruzi / Q000254:growth & development*