title: Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8.
abstract: We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.
authors.affiliation: Department of Internal Medicine (II), Okayama University Medical School, Okayama, Japan. nfujii@md.okayama-u.ac.jp
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Fujii
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ikeda
authors.forename: Naoto
authors.initials: N
authors.lastname: Takahashi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kojima
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ashiba
authors.forename: Katsuto
authors.initials: K
authors.lastname: Takenaka
authors.forename: Shunnichi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shinagawa
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Ishimaru
authors.forename: Kenji
authors.initials: K
authors.lastname: Niiya
authors.forename: Ikuo
authors.initials: I
authors.lastname: Miura
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
mesh_terms: D000208:Acute Disease; D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics*; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D023981:Sarcoma, Myeloid / Q000235:genetics*; D014314:Trisomy / Q000235:genetics*