Linear accelerator radiosurgery for meningiomas in and around the cavernous sinus.
OBJECTIVE
A retrospective study to evaluate the efficacy and side effects of linear accelerator radiosurgery in the treatment of cavernous sinus meningiomas.


METHODS
Between 1993 and 2001, 42 patients with meningiomas involving the cavernous sinus underwent linear accelerator radiosurgery at our institution. A mean radiation dose of 14 Gy was delivered to the tumor margin. The median tumor volume was 8.2 cm3 (mean, 8.4 cm3). Median follow-up was 36 months (mean, 38 mo).


RESULTS
Control of tumor growth was achieved in 97.5% of the patients. There was no mortality or permanent extraocular motor or pituitary dysfunction. Treatment-related complications included new trigeminal neuropathy in 4.7% and a new visual field defect in 2.8%. Two patients required shunt placement after developing hydrocephalus. One patient with symptomatic temporal lobe edema underwent partial excision of the tumor. Improvement of existing cranial neuropathies was noted in 29% of affected trigeminal nerves, in 22% of oculomotor nerves, and in 13% of Cranial Nerves IV and VI.


CONCLUSIONS
This study indicates that linear accelerator radiosurgery can achieve a high control rate of meningiomas involving the cavernous sinus with no mortality and a low incidence of morbidity.
Spiegelmann
Roberto
R
Stereotactic Radiosurgery Unit, Department of Neurosurgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
Nissim
Ouzi
O
Menhel
Janna
J
Alezra
Dror
D
Pfeffer
M Raphael
MR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002426:Cavernous Sinus / Q000601:surgery*; D003389:Cranial Nerve Diseases / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D008579:Meningioma / Q000175:diagnosis / Q000601:surgery*; D008875:Middle Aged; D010315:Particle Accelerators; D016634:Radiosurgery / Q000009:adverse effects; D016896:Treatment Outcome