Immune downregulation leads to upregulation of an antiviral response: a lesson from the hepatitis B virus.
Induction of tolerance towards antigens that drive susceptibility or pathology may be considered a new mode of treatment for several infections. Hepatitis B virus is a non-cytopathic virus, and oral immune regulation was shown to be effective in modulation of the immune-mediated liver injury.
Ilan
Yaron
Y
Liver Unit, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel. ilan@hadassah.org.il
D000222:Adaptation, Physiological / Q000276:immunology; D000284:Administration, Oral; D000956:Antigens, Viral / Q000008:administration & dosage / Q000276:immunology; D002908:Chronic Disease; D015536:Down-Regulation; D006509:Hepatitis B / Q000276:immunology* / Q000628:therapy; D006515:Hepatitis B virus / Q000276:immunology*; D007108:Immune Tolerance; D008107:Liver Diseases / Q000276:immunology; D018448:Models, Immunological; D015854:Up-Regulation
D000956:Antigens, Viral