title: Lymphoid lineage cells in adult murine bone marrow diverge from those of other blood cells at an early, hormone-sensitive stage.
abstract: Advances in cell sorting and GFP knock-in technology have made it possible to identify rare hematopoietic cells in murine bone marrow that are undergoing lymphocyte fate specification. Steroid hormones also represent important research tools for investigating relationships between different categories of lympho-hematopoietic precursors. By selectively blocking entry into and progression within lymphoid lineages, the hormones probably have a major influence on numbers of lymphocytes that are produced under normal circumstances. These issues are discussed within the context of developmental age-dependent changes that occur in the lymphopoietic process.
authors.affiliation: Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, USA. kincade@omrf.ouhsc.edu
authors.forename: Paul W
authors.initials: PW
authors.lastname: Kincade
authors.forename: Hideya
authors.initials: H
authors.lastname: Igarashi
authors.forename: Kay L
authors.initials: KL
authors.lastname: Medina
authors.forename: Taku
authors.initials: T
authors.lastname: Kouro
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yokota
authors.forename: Maria Isabel D
authors.initials: MI
authors.lastname: Rossi
authors.forename: John J T
authors.initials: JJ
authors.lastname: Owen
authors.forename: Karla P
authors.initials: KP
authors.lastname: Garrett
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Sun
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sakaguchi
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006728:Hormones / Q000276:immunology / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D038041:Lymphopoiesis / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
chemical_list: D006728:Hormones