[Review of relationship between vascular endothelial growth factor C & D and lymph node metastasis of malignant tumor].
The mechanism and inhibition of lymph node metastasis of malignant tumor are one of the research hot points. There are many researches indicating that vascular endothelial growth factor-C(VEGF-C) and vascular endothelial growth factor-D(VEGF-D) were closely associated with lymph node metastasis of malignant tumor. This article mainly reviewed the structures, functional characteristics, possible mechanisms of VEGF-C and VEGF-D in lymph node metastasis, and current progress of inhibition of lymph node metastasis of malignant tumor.
Li
Qiu-li
QL
Department of Head & Neck, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P. R. China. Liq99@163.net
Chen
Fu-jing
FJ
D016228:Endothelial Growth Factors / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D
D016228:Endothelial Growth Factors; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D