Protein adsorption-resistant hollow fibers for blood purification.
Nonfouling polysulfone (PSf) hollow fiber membranes resistant to protein adsorption and deposition were newly developed by the addition of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. To improve hydrophilicity, permeability, and nonfouling characteristics of the PSf hollow fiber in a hemodialyzer, we synthesized a MPC polymer which can be blended with PSf for preparing the polymer alloy (PSf/MPC polymer). The composition of the MPC polymer blended in the PSf was in the range between 7.0 and 15 wt%. From the PSf/MPC polymer solution, flat membranes and hollow fibers could be prepared. These membranes took an asymmetric structure, and its mechanical strength was good. The surface characterization of the PSf/MPC polymer hollow fiber membrane by X-ray photoelectron spectroscopy revealed that the MPC units were concentrated at the surface. The permeability for solutes through the PSf/MPC polymer membrane was higher, and the amount of protein adsorbed on the PSf/MPC polymer membrane was lower than those of the PSf membrane. Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer membrane.
Ishihara
Kazuhiko
K
Department of Materials Engineering, School of Engineering, The University of Tokyo, Japan. ishihara@bmw.t.u-tokyo.ac.jp
Hasegawa
Takashi
T
Watanabe
Junji
J
Iwasaki
Yasuhiko
Y
D000327:Adsorption; D001672:Biocompatible Materials; D001798:Blood Proteins; D006801:Humans; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D008689:Methacrylates; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D010767:Phosphorylcholine / Q000031:analogs & derivatives*; D010973:Platelet Adhesiveness; D011108:Polymers; D011109:Polymethacrylic Acids; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones
D001672:Biocompatible Materials; D001798:Blood Proteins; D008567:Membranes, Artificial; D008689:Methacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; D013450:Sulfones; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; C017662:polysulfone P 1700