title: Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: an MRS study.
abstract: OBJECTIVE
  To help determine the effects of dextro-amphetamine on the phosphoinositol cycle (PI-cycle) in humans, (1)H and (31)P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open-label study carried out before and after administration of 20 mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS).
  
  
  RESULTS
  Following dextro-amphetamine administration there was a significant increase in the concentrations of both myo-inositol and phosphomonoesters.
  
  
  CONCLUSIONS
  These findings are in keeping with suggestions that dextro-amphetamine administration increases the activity of the phosphoinositol cycle, probably via an indirect release of dopamine and noradrenaline. These results are the first time that this has been confirmed in humans.
authors.affiliation: Department of Psychiatry, University Hospital, University of Alberta, Edmonton, Alberta T6G 2B7, Canada. peter.silverstone@ualberta.ca
authors.forename: Peter H
authors.initials: PH
authors.lastname: Silverstone
authors.forename: Tina
authors.initials: T
authors.lastname: O'Donnell
authors.forename: Michele
authors.initials: M
authors.lastname: Ulrich
authors.forename: Sheila
authors.initials: S
authors.lastname: Asghar
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Hanstock
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000494:pharmacology*; D003401:Creatine / Q000378:metabolism; D003913:Dextroamphetamine / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*
chemical_list: D000697:Central Nervous System Stimulants; D010716:Phosphatidylinositols; D007294:Inositol; D003401:Creatine; D003913:Dextroamphetamine