[Fulminant thrombotic thrombocytopenic purpura in the course of ciprofloxacin therapy].
We report on a 43-year-old woman who developed a fulminant thrombotic thrombocytopenic purpura (TTP) in the early course of an oral ciprofloxacin therapy. An acute bacterial meningo-encephalitis with disseminated intravascular coagulation was first suspected. She also presented with haemolytic anaemia and a severe thrombocytopenia. The lumbar puncture was delayed and only performed after platelets transfusions. CSF examination ruled out meningo-encephalitis. A diagnosis of TTP was made and she was given plasma exchanges. However, her neurological status worsened and the cranial CT revealed a subarachnoidal hemorrhage in left sylvian valley with diffuse oedema predominating in the left cerebral hemisphere and multiple ischemic lacunes. She died four days after admission.
Mouraux
A
A
Service de Neurologie, Cliniques de l'Europe, Site Sainte-Elisabeth, Bruxelles, Belgique, France.
Gille
M
M
Piéret
F
F
Declercq
I
I
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001921:Brain / Q000000981:diagnostic imaging*; D002939:Ciprofloxacin / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000890:Anti-Infective Agents; D002939:Ciprofloxacin