title: Effects of sorbent suspension dialysis on plasma amino acid levels in cirrhotic patients with refractory hepatic encephalopathy.
abstract: In cirrhotic patients, plasma amino acid levels are severely deranged. A decreased ratio of branched-chain to aromatic amino acids (Fischer ratio) has been implicated in the pathogenesis of hepatic encephalopathy. In this prospective study, we investigated the effects of extracorporeal detoxification on amino acid levels using a sorbent suspension dialysis system. Twenty patients with documented cirrhosis and hepatic encephalopathy grade II-III not responding to standard treatment were randomized to receive either six hours of sorbent dialysis and standardized conventional medical treatment or ongoing medical treatment alone. In contrast to previous uncontrolled studies, no significant effect on amino acid levels, Fischer ratio or clinical grade of hepatic encephalopathy was detected in either treatment group. In conclusion, a 6-hour treatment with sorbent dialysis did not significantly influence plasma levels of amino acids and did not ameliorate the clinical grade of hepatic encephalopathy.
authors.affiliation: Department of Medicine IV, University of Vienna Medical School, Vienna, Austria. edith.bauer@akh-wien.ac.at
authors.forename: E
authors.initials: E
authors.lastname: Bauer
authors.forename: A
authors.initials: A
authors.lastname: Gendo
authors.forename: C
authors.initials: C
authors.lastname: Madl
authors.forename: F
authors.initials: F
authors.lastname: Garo
authors.forename: E
authors.initials: E
authors.lastname: Roth
authors.forename: L
authors.initials: L
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D005112:Extracorporeal Circulation; D005260:Female; D006501:Hepatic Encephalopathy / Q000097:blood / Q000150:complications* / Q000628:therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016060:Sorption Detoxification
chemical_list: D000596:Amino Acids