title: Preoperative assessment of ovarian tumors by CA 125 measurement and transvaginal color Doppler ultrasound.
abstract: The accuracy of combined use of serum CA 125 and transvaginal color Doppler for preoperative assessment of ovarian lesions in premenopausal patients was evaluated. Seventy-six ovarian lesions were analyzed the day before surgery using transvaginal color Doppler ultrasound. On the same day, serum CA 125 was measured in each patient. A novel index is proposed for the detection of ovarian malignancy combining resistance index (RI) obtained from newly formed vessels within the ovarian lesion and serum CA 125 level: (RI/CA 125) x 100. Values below the cut-off value of 1.5 were associated with a high risk of ovarian malignancy. Assessment of ovarian lesions by the novel index had a sensitivity and specificity of 94.44% and 100%, while positive and negative predictive values were 100% and 98.31%, respectively. The best prediction of ovarian malignancy was achieved by a combined use of transvaginal color Doppler ultrasound and serum CA 125 in the form of index: (RI/CA 125) x 100.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, University of Zagreb, Sveti Duh General Hospital, HR-10000 Zagreb, Croatia. sanja.kupesic@zg.tel.hr
authors.forename: Sanja
authors.initials: S
authors.lastname: Kupesić
authors.forename: Sanja
authors.initials: S
authors.lastname: Vujisić
authors.forename: Asim
authors.initials: A
authors.lastname: Kurjak
authors.forename: Daria
authors.initials: D
authors.lastname: Mihaljević
authors.forename: Senka
authors.initials: S
authors.lastname: Radosević
mesh_terms: D000328:Adult; D018394:CA-125 Antigen / Q000097:blood*; D003536:Cystadenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D011237:Predictive Value of Tests; D017697:Premenopause; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color
chemical_list: D018394:CA-125 Antigen