title: Monitoring the correct use of isometamidium by farmers and veterinary assistants in Eastern Province of Zambia using the isometamidium-ELISA.
abstract: A survey to monitor the use of trypanocidal drugs by cattle breeders was conducted in Zambia. Use was made of a questionnaire and of the isometamidium-ELISA technique. One hundred and twenty-two farmers and 50 veterinary assistants were interviewed. The isometamidium-ELISA was used to monitor the isometamidium serum concentration in 72 cattle, 1 week after unsupervised treatment by 56 farmers and 16 veterinary assistants. Although there was no clear indication of underestimation of the weight of the animals and although farmers had adequate knowledge of the correct usage of isometamidium, the results suggest frequent underdosing when considering isometamidium serum concentrations 1 week after treatment. In 76% of the cases, the expected protection period was equal or shorter than 28 days and equal or shorter than 33 days in 90% of the treated cattle.
authors.affiliation: Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium. vdelespaux@itg.be
authors.forename: V
authors.initials: V
authors.lastname: Delespaux
authors.forename: S
authors.initials: S
authors.lastname: Geerts
authors.forename: J
authors.initials: J
authors.lastname: Brandt
authors.forename: R
authors.initials: R
authors.lastname: Elyn
authors.forename: M C
authors.initials: MC
authors.lastname: Eisler
mesh_terms: D000818:Animals; D001835:Body Weight; D002417:Cattle; D004363:Drug Utilization; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D010617:Phenanthridines / Q000097:blood / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D014344:Trypanocidal Agents / Q000097:blood / Q000627:therapeutic use*; D014345:Trypanosoma; D014354:Trypanosomiasis, Bovine / Q000469:parasitology / Q000517:prevention & control*; D015024:Zambia
chemical_list: D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride