title: Dopamine does not correct oxygen consumption/oxygen delivery relation abnormality during vasomotor shock induced by interleukin-1beta.
abstract: We previously showed that interleukin 1beta (IL-1beta) induces vasomotor shock and impairs the oxygen consumption (VO2)/oxygen delivery (DO2) relation by increasing the slope of the supply-independent line in rabbits. In the present study, we investigated the inotropic effect of dopamine on the VO2/DO2 abnormality induced by IL-1beta. Twelve rabbits were divided into two groups (n = 6, each) and were given 10 microg/kg of IL-1beta or saline (control) intravenously. After baseline measurements were obtained, dopamine was infused continuously at a rate of 20 microg/kg/min throughout the study in both groups. All rabbits were subjected to stepwise cardiac tamponade to reduce the DO2 to <5 mL/min/kg by inflation of a handmade balloon placed into the pericardial sac. The VO2/DO2 relation was then analyzed by the dual-line method. Dopamine failed to correct the IL-1beta-induced decrease in mean arterial pressure to the baseline level. Dopamine significantly increased cardiac index in both groups, resulting in significant increases in DO2 (IL-1beta, 28.5 +/- 6.0 mL/min/kg from baseline 24.1 +/- 3.5 mL/min/kg; control, 27.7 +/- 2.9 mL/min/kg from baseline 22.9 +/- 2.9 mL/min/kg), but did not affect VO2 (IL-1beta, 10.0 +/- 0.5 mL/min/kg from baseline 9.9 +/- 0.7 mL/min/kg; control, 10.2 +/- 0.4 mL/min/kg from baseline 10.2 +/- 0.2 mL/min/kg). The IL-1beta group showed a significantly greater supply-independent line slope than that of controls (IL-1beta, y = 0.14x + 6.3; control, y = 0.06x + 8.6) during stepwise decreases in DO2. These results indicate that continuous infusion of dopamine at 20 microg/kg/min increases DO2 but does not correct the vasomotor disturbance or VO2/DO2 abnormality caused by IL-1beta.
authors.affiliation: Department of Acute Critical Medicine (D-8), Osaka University Medical School, Yamadaoka 2-15, Suita, Osaka 585-0871, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kuwagata
authors.forename: Jun
authors.initials: J
authors.lastname: Oda
authors.forename: Shigenari
authors.initials: S
authors.lastname: Matsuyama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujimi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogura
authors.forename: Masato
authors.initials: M
authors.lastname: Nishino
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sugimoto
mesh_terms: D000818:Animals; D002305:Cardiac Tamponade; D004195:Disease Models, Animal; D004298:Dopamine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000097:blood / Q000150:complications / Q000378:metabolism; D007375:Interleukin-1 / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D011817:Rabbits; D012769:Shock / Q000097:blood / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D010100:Oxygen; D004298:Dopamine