title: HIV-1 epidemic trends in rural south-west Uganda over a 10-year period.
abstract: The objective of this study was to examine the epidemic trends of HIV-1 infection in a rural population cohort in Uganda followed for 10 years. The methods used were to assess incidence and prevalence trends in adults in this longitudinal cohort study. The results showed that incidence of infection has fallen significantly in all adults, and separately in males, females, young adults and older adults over the course of the study period. There was also a reduction in prevalence, especially in young men and women. There was some evidence of a cohort effect in women. The conclusions are that this study provides the first evidence of a falling incidence in a rural general population in Africa. This was an observational cohort exposed to national health education messages, giving hope that similar campaigns elsewhere in Africa could be used effectively in efforts to control the HIV epidemic.
authors.affiliation: Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda. jimmy.whitworth@lshtm.ac.uk
authors.forename: J A G
authors.initials: JA
authors.lastname: Whitworth
authors.forename: C
authors.initials: C
authors.lastname: Mahe
authors.forename: S M
authors.initials: SM
authors.lastname: Mbulaiteye
authors.forename: J
authors.initials: J
authors.lastname: Nakiyingi
authors.forename: A
authors.initials: A
authors.lastname: Ruberantwari
authors.forename: A
authors.initials: A
authors.lastname: Ojwiya
authors.forename: A
authors.initials: A
authors.lastname: Kamali
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D015528:HIV Seroprevalence / Q000639:trends*; D015497:HIV-1; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D012424:Rural Population / Q000706:statistics & numerical data*; D017678:Sex Distribution; D014454:Uganda / Q000453:epidemiology