Treatment of the SpA-like disease in HLA B27 transgenic animals.
A major involvement of the immune system and of microbial flora in the HLA-B27 transgenic rat model of spondylarthropathy was demonstrated. The role of inflammatory pathways, such as cytokines and inducible nitric oxide synthase (iNOS) was investigated. Treatment with IL-10 failed to improve established disease, whereas such improvement was achieved with IL-11. In contrast, aggravation was observed after treatment with selective inhibitor of iNOS.
Breban
M
M
INSERM U567 and Service de Rhumatologie B, Hôpital Cochin, Université René Descartes, Paris, France. maxime.breban@cch.ap-hop-paris.fr
May
E
E
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics; D001421:Bacteria, Anaerobic / Q000502:physiology; D015796:HLA-B27 Antigen / Q000235:genetics*; D007107:Immune System / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D017370:Interleukin-11 / Q000627:therapeutic use; D051381:Rats; D025242:Spondylarthropathies / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*
D015796:HLA-B27 Antigen; D018836:Inflammation Mediators; D017370:Interleukin-11