title: Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.
abstract: We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.
authors.affiliation: Departments of Pathology and Surgery, University of Hong Kong, Hong Kong, China.
authors.forename: Suet Y
authors.initials: SY
authors.lastname: Leung
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Kent M
authors.initials: KM
authors.lastname: Chu
authors.forename: Siu T
authors.initials: ST
authors.lastname: Yuen
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mathy
authors.forename: Jiafu
authors.initials: J
authors.lastname: Ji
authors.forename: Annie S Y
authors.initials: AS
authors.lastname: Chan
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Simon
authors.initials: S
authors.lastname: Law
authors.forename: Olga G
authors.initials: OG
authors.lastname: Troyanskaya
authors.forename: I-Ping
authors.initials: IP
authors.lastname: Tu
authors.forename: John
authors.initials: J
authors.lastname: Wong
authors.forename: Samuel
authors.initials: S
authors.lastname: So
authors.forename: David
authors.initials: D
authors.lastname: Botstein
authors.forename: Patrick O
authors.initials: PO
authors.lastname: Brown
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D018076:DNA, Complementary / Q000235:genetics; D018450:Disease Progression; D004790:Enzyme Induction; D005753:Gastric Mucosa / Q000201:enzymology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D054501:Group II Phospholipases A2; D006801:Humans; D017403:In Situ Hybridization; D015993:Life Tables; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D010741:Phospholipases A / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D054467:Phospholipases A2; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D016019:Survival Analysis
chemical_list: D018076:DNA, Complementary; D009363:Neoplasm Proteins; D010741:Phospholipases A; D054501:Group II Phospholipases A2; C516287:PLA2G2A protein, human; D054467:Phospholipases A2; C516288:Pla2g2a protein, mouse