title: Value of recombinant human thyrotropin in high-dose radioiodine therapy: a case report.
abstract: We report on a high-dose radioiodine therapy after injection of recombinant human thyrotropin (rhTSH) in a 61-y-old woman with compression of the spinal cord caused by metastasis of a follicular thyroid carcinoma. Fourteen years ago, the patient underwent subtotal thyroidectomy because of multinodular goiter without any histologic evidence for malignant disease, and the patient was put on thyroxine substitution (100 micro g/d). In April 2000, she developed paralysis of the right leg. Morphologic imaging revealed spinal compression caused by a space-occupying lesion within the thoracic spine. Subsequent biopsy and histology demonstrated metastasis of a follicular thyroid carcinoma. Therefore, high-dose radioiodine therapy was scheduled after 4 wk of hormone withdrawal. Within a few days of being off thyroxine, the patient's paralytic symptoms worsened rapidly. The patient was again put on thyroxine, 100 micro g/d, and high-dose radioiodine therapy under stimulation with rhTSH was performed without any side effects. The second high-dose radioiodine therapy 3 mo later, again performed under stimulation with rhTSH, showed significantly less iodine avidity, and thyroglobulin levels fell from 1,024 micro g/L to 361 micro g/L, thereby demonstrating therapeutic efficacy. Thus, rhTSH might be used as a tool not only in the diagnostic application but also in the therapeutic application of (131)I.
authors.affiliation: Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany.
authors.forename: Vika
authors.initials: V
authors.lastname: Müller
authors.forename: Karl H
authors.initials: KH
authors.lastname: Bohuslavizki
authors.forename: Susanne
authors.initials: S
authors.lastname: Klutmann
authors.forename: Malte
authors.initials: M
authors.lastname: Clausen
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D013125:Spinal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary; D013904:Thoracic Vertebrae; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D013972:Thyrotropin / Q000627:therapeutic use*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins; D013972:Thyrotropin