Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.
Rosen
Rachel
R
Division of Pediatric Gastroenterology and Inflammatory Bowel Disease Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Integlia
Mark J
MJ
Bousvaros
Athos
A
D000293:Adolescent; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D002675:Child, Preschool; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D005838:Genotype; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects* / Q000627:therapeutic use; D008780:Methyltransferases / Q000172:deficiency* / Q000235:genetics; D010198:Pancytopenia / Q000139:chemically induced* / Q000517:prevention & control
D007166:Immunosuppressive Agents; D015122:Mercaptopurine; D008780:Methyltransferases; C022745:thiopurine methyltransferase; D001379:Azathioprine