title: Intake retention fractions developed from models used in the determination of dose coefficients developed for ICRP publication 68--particulate inhalation.
abstract: ICRP Publication 68 presents dose coefficients developed using systems of new models for the respiratory tract and metabolism of certain elements. The utility of these dose coefficients and associated models is limited without a method for calculating intake from bioassay results using the same models as in that publication. The calculation of a radionuclide intake requires values of expected fractions of the intake in bioassay samples collected at specific times after intake. The general system of models has been solved using a commercial software package and a method for solution of systems of first-order linear differential equations that uses eigenvectors and eigenvalues derived from the system of equations. The result of this work is a series of tables of fractions of acute inhalation intakes for different bioassay methods, times, and compound classes for intakes for those elements listed in ICRP Publication 68. The values in these tables can be used for intake calculations, development of bioassay frequencies, and development of action levels.
authors.affiliation: Sandia National Laboratories, P.O. Box 5800, Albuquerque, NM 87185-0651, USA. capotte@sandia.gov
authors.forename: Charles A
authors.initials: CA
authors.lastname: Potter
mesh_terms: D000280:Administration, Inhalation; D000576:Americium / Q000627:therapeutic use; D001681:Biological Assay; D003198:Computer Simulation; D006801:Humans; D008452:Maximum Allowable Concentration; D015233:Models, Statistical; D008962:Models, Theoretical; D011829:Radiation Dosage; D011834:Radiation Monitoring; D011868:Radioisotopes; D011874:Radiometry; D012137:Respiratory System / Q000528:radiation effects*; D012984:Software
chemical_list: D011868:Radioisotopes; D000576:Americium