Amyloid deposition of systemic myeloma-associated amyloidosis excludes actinic elastotic material.
We report a 65-year-old Japanese man presenting with myeloma-associated systemic amyloidosis. A biopsy specimen taken from the purpuric papules on the periorbital area showed the presence of both amyloid and elastotic materials (actinic elastosis) in the upper dermis. Amyloid deposition and altered elastotic fibers were clearly bordered and never colocalized, and amyloid materials appeared to exclude elastotic materials. The mechanism of this phenomenon is discussed.
Wada
Naoko
N
Department of Derrmatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. nwada@xc4.so-net.jp
Fujimoto
Norihiro
N
Komatsu
Takehiko
T
Tajima
Shingo
S
Ishibashi
Akira
A
D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001707:Biopsy, Needle; D003907:Dexamethasone / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use*; D004547:Elastic Tissue / Q000473:pathology*; D005143:Eyelids; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000150:complications / Q000473:pathology*; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use*
D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin