[Study on antiplatelet effect of radix astragali total saponin combined with Radix paeoniae rubra glucosides].
OBJECTIVE
To research effects of Radix Astragali total saponin combined with Radix Paeoniae Rubra glucosides (double glucosides of Qi-Shao, DGQS) on antiplatelet.


METHODS
Antiplatelet effect of DGQS at three dosages (100 mg/kg, 200 mg/kg, 400 mg/kg) were studied. And levels of granule membrane protein 140 (GMP-140), TXA2 and PGI2 in rat plasma were determined.


RESULTS
DGQS as whole could restrain platelet aggregation, decrease content of GMP-140, bring down level of TXA2/PGI2.


CONCLUSIONS
DGQS had apparent antiplatelet effect.
Xu
Xianxiang
X
First Affiliated Hospital of Anhui College of TCM, Hefei 230031.
Xia
Lunzhu
L
Gao
Jiarong
J
Liu
Qingyun
Q
Peng
Daiyin
D
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D011464:Epoprostenol / Q000097:blood; D005260:Female; D005960:Glucosides / Q000494:pharmacology*; D006386:Hemagglutination Tests; D008297:Male; D019007:P-Selectin / Q000097:blood; D029596:Paeonia / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000097:blood
D004365:Drugs, Chinese Herbal; D005960:Glucosides; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors; D012503:Saponins; D013928:Thromboxane A2; D011464:Epoprostenol