New cytotoxic constituents from the Formosan soft corals Clavularia viridis and Clavularia violacea.
Three new cytotoxic prostanoids, claviridenone E-G (1-3), and three new cytotoxic steroids, stoloniferone E-G (4-6), were isolated from the methylene chloride solubles of the Formosan soft coral Clavulariaviridis. A cytotoxic cembranoid, claviolide (7), was isolated from the methylene chloride solubles of the Formosan soft coral Clavularia violacea. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Duh
Chang-Yih
CY
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. yihduh@mail.nsysu.edu.tw
El-Gamal
Ali Ali H
AA
Chu
Chih-Ju
CJ
Wang
Shang-Kwei
SK
Dai
Chang-Feng
CF
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D008175:Lung Neoplasms; D008752:Methylene Chloride; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011453:Prostaglandins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D011453:Prostaglandins; D013256:Steroids; C471277:claviridenone E; C471279:claviridenone F; C471280:claviridenone G; C471281:stoloniferone E; C471282:stoloniferone F; C471283:stoloniferone G; D008752:Methylene Chloride