title: Acute renal dysfunction associated with selective COX-2 inhibitor therapy.
abstract: The recent release of the selective cyclooxygenase-2 (COX-2) enzyme inhibitors for the treatment of various inflammatory disorders and pain syndromes has been associated with a clear-cut decrease in adverse gastrointestinal effects. The nephrotoxic effect of selective COX-2 inhibitors has not yet been firmly established. We report a case of reversible acute renal failure due to rofecoxib treatment in an elderly patient with several risk factors associated with traditional nonselective nonsteroidal anti-inflammatory drug (NSAID)-related nephrotoxicity. It is prudent to approach therapy with selective COX-2 inhibitors cautiously and in a fashion similar to traditional NSAID therapy for patients with risk factors that induce prostaglandin-dependent renal function.
authors.affiliation: Department of Medicine and Urology, Arta General Hospital, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Papaioannides
authors.forename: C
authors.initials: C
authors.lastname: Bouropoulos
authors.forename: D
authors.initials: D
authors.lastname: Sinapides
authors.forename: P
authors.initials: P
authors.lastname: Korantzopoulos
authors.forename: N
authors.initials: N
authors.lastname: Akritidis
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D007668:Kidney / Q000187:drug effects; D007783:Lactones / Q000009:adverse effects*; D008297:Male; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases; D013450:Sulfones
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D007783:Lactones; D008565:Membrane Proteins; D013450:Sulfones; C116926:rofecoxib; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases