title: Structure of the 70 S ribosome: implications for movement.
abstract: The ribosome is a complex molecular machine, with moving parts, many of which are structural elements of rRNA. We compared the X-ray crystal structures of three different functional states of the 30 S ribosomal subunit - two from crystal structures of the isolated 30 S subunit from the Ramakrishnan group and one from a complex of the 70 S ribosome. Even though all three structures are in what could be called the 'ground state' of the subunit, many conformational differences are found, distributed over the whole structure. A striking example is the undulating movement of the penultimate stem of 16S rRNA, which forms several intersubunit bridges with the 50 S subunit.
authors.affiliation: Center for Molecular Biology of RNA, UCSC, Santa Cruz, CA 95064, USA. harry@nuvolari.ucsc.edu
authors.forename: H F
authors.initials: HF
authors.lastname: Noller
authors.forename: A
authors.initials: A
authors.lastname: Baucom
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012335:RNA, Ribosomal / Q000737:chemistry*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry; D012270:Ribosomes / Q000737:chemistry*
chemical_list: D012335:RNA, Ribosomal; D012336:RNA, Ribosomal, 16S