title: Rationale and methods for the National Tuberculosis Genotyping and Surveillance Network.
abstract: Our understanding of tuberculosis (TB) transmission dynamics has been refined by genotyping of Mycobacterium tuberculosis strains. The National Tuberculosis Genotyping and Surveillance Network was designed and implemented to systematically evaluate the role of genotyping technology in improving TB prevention and control activities. Genotyping proved a useful adjunct to investigations of outbreaks, unusual clusters, and laboratory cross-contamination.
authors.affiliation: Division of Tuberculosis Elimination, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. kcastro@cdc.gov
authors.forename: Kenneth G
authors.initials: KG
authors.lastname: Castro
authors.forename: Harold W
authors.initials: HW
authors.lastname: Jaffe
mesh_terms: D015373:Bacterial Typing Techniques / Q000379:methods; D002487:Centers for Disease Control and Prevention, U.S. / Q000458:organization & administration; D003140:Communicable Disease Control / Q000458:organization & administration*; D016172:DNA Fingerprinting / Q000379:methods; D016208:Databases, Factual; D005838:Genotype; D006291:Health Policy; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D012307:Risk Factors; D018571:Sentinel Surveillance; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D014481:United States