Cycloartane and oleanane saponins from egyptian astragalus spp. as modulators of lymphocyte proliferation.
From the roots of Astragalus kahiricus DC., three known saponins, namely, astraversianin VI, astraversianin X, astragaloside VIII, and a new saponin were isolated and identified by spectral data. The structure of the latter was elucidated by spectral means and assigned as cycloastragenol 3- O-[ beta- D-(2',3'-diacetyl, 4'- trans-2-butenoyl)-xylopyranosyl], 6- O- beta- D-xylopyranoside (kahiricoside I). From the aerial parts of A. hamosus L., the known compounds azukisaponin V and peregrinoside I were isolated. As judged by in vitro tests, the saponins isolated from Astragalus spp. endemic to Egypt were not cytotoxic against a variety of human cancer cells. However, dose-related modulation of lymphocyte proliferation was observed, and structure-activity relationships are described.
Verotta
Luisella
L
Dipartimento di Chimica Organica e Industriale, Milano, Italy. luisella.verotta@unimi.it
Guerrini
Marco
M
El-Sebakhy
Nadia A
NA
Assad
Aya M
AM
Toaima
Soad M
SM
Radwan
Mohamed M
MM
Luo
Ying-De
YD
Pezzuto
John M
JM
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D027883:Astragalus Plant; D004305:Dose-Response Relationship, Drug; D004534:Egypt; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D051379:Mice; D008815:Mice, Inbred Strains; D009828:Oleanolic Acid / Q000031:analogs & derivatives; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012503:Saponins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; C085352:cycloartane; D009828:Oleanolic Acid