Synthesis and biological evaluation of aristolactams.
A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line.
Couture
Axel
A
Laboratoire de Chimie Organique Physique, ESA CNRS 8009, Bâtiment C3(2), UST Lille, F-59655 Villeneuve d'Ascq Cédex, France. axel.couture@univ-lille1.fr
Deniau
Eric
E
Grandclaudon
Pierre
P
Rybalko-Rosen
Hélène
H
Léonce
Stéphane
S
Pfeiffer
Bruno
B
Renard
Pierre
P
D000818:Animals; D034341:Aristolochic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007769:Lactams; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D034341:Aristolochic Acids; D007769:Lactams