title: Polysulfide derivatives from Ferula foetida.
abstract: The ethyl acetate-soluble fraction from a methanol extract of Ferula foetida has afforded six new sulfide derivatives, (E)-3-methylsulfinyl-2-propenyl sec-butyl disulfide (foetisulfide A) (1), (Z)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide B) (2), (E)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide C) (3), bis(3-methylthio-2E-propenyl) disulfide (foetisulfide D) (4), 3,4,5-trimethyl-2-thiophenecarboxylic acid (foetithiophene A) (5), 3,4,5-trimethyl-2-(methylsulfinyloxymethyl)thiophene (foetithiophene B) (6), along with six known compounds. The structures of 1-6 were established on the basis of spectroscopic studies, with the elucidation of 5 confirmed by single-crystal X-ray crystallography.
authors.affiliation: The College of Pharmaceutical and Biotechnology, Tianjin University, 92 Weijin Road, Tianjin 300072, People's Republic of China.
authors.forename: Hongquan
authors.initials: H
authors.lastname: Duan
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Motoo
authors.initials: M
authors.lastname: Tori
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takaoka
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
authors.forename: Olimjon K
authors.initials: OK
authors.lastname: Kodzhimatov
authors.forename: K
authors.initials: K
authors.lastname: Kodzhimatov
authors.forename: Ozodbek
authors.initials: O
authors.lastname: Ashurmetov
mesh_terms: D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D005309:Ferula / Q000737:chemistry*; D008519:Medicine, Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry / Q000302:isolation & purification*; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification; D014610:Uzbekistan
chemical_list: D013440:Sulfides; D013876:Thiophenes; C032915:polysulfide