Functional connectivity between neurons generating resting discharge in renal sympathetic neurons in the rabbit.
In anaesthetised rabbits, we analysed the cross-correlations of resting discharges in pairs of simultaneously recorded renal neurons. The study of 428 significant cross-correlations showed three pure types of neuronal co-ordination and two combined effects. Pure shared input was observed in 202 pairs of neurons (47.2%). The width of cross-correlogram peak was 222.9 +/- 7.2 ms. The peak height of shared input was 4.8 +/- 0.2 spikes s(-1) and was significantly related with correlogram width. Pure excitatory connection was found in 24 neuronal pairs (5.6%). Its peak width was 7.9 +/- 1.9 ms and it was shifted from time zero by 13.3 +/- 3.4 ms. The amplitude of the peak was 19.6 +/- 4.6 spikes s(-1). In 165 pairs of neurons (38.6%), excitatory connection was combined with shared input component. Pure reciprocal activation was seen in only 5 pairs of neurons (1.1%) while in 32 pairs (7.5%) it was accompanied by shared input co-ordination. The distance between narrow peaks measured in the combined type of co-ordination was 32.5 +/- 3.5 ms and the mean peak height was 4.1 +/- 0.7 spikes s(-1). Shared input in pure form and that accompanying both excitatory connection and reciprocal activation were significantly related to the frequency of discharge of neurons contributing to the cross-correlogram. The incidence and basic properties of the encountered types of neural coordination may indicate a pattern of interconnections between cells generating vasomotor tone in renal sympathetic neurons.
Lupa
K
K
Department of Human Physiology, University Medical School, 20-080 Lublin, Radziwillowska 11, Poland.
Tarnecki
R
R
Pencuła
M
M
Niechaj
A
A
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D005260:Female; D007668:Kidney / Q000294:innervation* / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology*; D009434:Neural Pathways; D009474:Neurons / Q000502:physiology*; D011817:Rabbits; D011930:Reaction Time; D013564:Sympathetic Nervous System / Q000502:physiology*; D009435:Synaptic Transmission