Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy.
Lomas
David A
DA
Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, United Kingdom. dal16@cam.ac.uk
Mahadeva
Ravi
R
D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D046911:Macromolecular Substances; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000737:chemistry / Q000378:metabolism*; D019896:alpha 1-Antitrypsin Deficiency / Q000378:metabolism / Q000473:pathology
D046911:Macromolecular Substances; D015842:Serine Proteinase Inhibitors; D015843:Serpins; D000515:alpha 1-Antitrypsin